Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis. (1/411)

The small molecule direct thrombin inhibitor L-374,087 was characterized across species in an in vitro activated partial thromboplastin clotting time (aPTT) assay and in vivo in rhesus monkey and dog thrombosis models. In vitro in rhesus, dog, and human plasma, L-374,087 concentrations eliciting 2-fold increases in aPTT were 0.25, 1.9, and 0.28 microM, respectively. In anesthetized rhesus monkeys, 300 microgram/kg bolus plus 12 microgram/kg/min and 300 microgram/kg bolus plus 30 microgram/kg/min L-374,087 i.v. infusions significantly reduced jugular vein thrombus extension, with both regimens limiting venous thrombus extension to 2-fold that of baseline thrombus mass compared with a 5-fold extension observed in the vehicle control group. Antithrombotic efficacy in the rhesus with the lower-dose regimen was achieved with 2.3- to 2.4-fold increases in aPTT and prothrombin time. In a conscious instrumented dog model of electrolytic vessel injury, the oral administration of two 10 mg/kg L-374,087 doses 12 h apart significantly reduced jugular vein thrombus mass, reduced the incidence of and delayed time to occlusive coronary artery thrombosis, and significantly reduced coronary artery thrombus mass and ensuing posterolateral myocardial infarct size. Antithrombotic efficacy in the dog was achieved with 1.6- to 2.0-fold increases in aPTT at 1 to 6 h after oral dosing with L-374,087. These results indicate significant antithrombotic efficacy against both venous and coronary arterial thrombosis with L-374,087 with only moderate elevations in aPTT or prothrombin time. The oral efficacy of L-374,087 characterizes this compound as a prototype for the further development of orally active direct thrombin inhibitors.  (+info)

Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. (2/411)

Agonists induce inside-out alphaIIbbeta3 signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in further platelet stimulation. Because the Syk tyrosine kinase is activated during both phases of integrin signaling, we evaluated its role in alphaIIbbeta3 function in murine platelets rendered null for Syk by gene targeting and in human platelets incubated with piceatannol, a tyrosine kinase inhibitor reportedly selective for Syk. Both Syk null murine platelets and piceatannol-treated human platelets exhibited a partial, but statistically significant defect in activation of alphaIIbbeta3 by adenine diphosphate (ADP) +/- epinephrine as assessed by fibrinogen binding. Syk null platelets adhered normally to immobilized fibrinogen, and mice with these platelets exhibited normal tail bleeding times. In contrast, piceatannol treatment of human platelets completely inhibited platelet adhesion to immobilized fibrinogen. The discrepancy in extent of integrin dysfunction between murine and human platelet models may be due to lack of specificity of piceatannol, because this compound inhibited the activity of Src and FAK as well as Syk and also reduced tyrosine phosphorylation of multiple platelet proteins. These results provide genetic evidence that Syk plays a role in alphaIIbbeta3 signaling in platelets and pharmacological evidence that, although piceatannol also inhibits alphaIIbbeta3 signaling, it does so by inhibtion of multiple protein tyrosine kinases.  (+info)

Suppression of platelet aggregation by Bordetella pertussis adenylate cyclase toxin. (3/411)

The effect of Bordetella pertussis adenylate cyclase toxin (ACT) on platelet aggregation was investigated. This cell-invasive adenylate cyclase completely suppressed ADP (10 microM)-induced aggregation of rabbit platelets at 3 micrograms/ml and strongly suppressed thrombin (0. 2 U/ml)-induced aggregation at 10 micrograms/ml. The suppression was accompanied by marked increase in platelet intracellular cyclic AMP (cAMP) content and was diminished by the anti-ACT monoclonal antibody B7E11. A catalytically inactive point mutant of ACT did not show the suppressive effect. Since an increase of cAMP content is a known cause of platelet dysfunction, these results indicate that the observed platelet inactivation was due to the catalytic activity of ACT through increase of intracellular cAMP.  (+info)

Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. (4/411)

Endothelial nitric oxide synthase (eNOS) has been identified in human platelets. Although platelet-derived nitric oxide (NO) has been shown to inhibit platelet recruitment in vitro, its role in the regulation of the hemostatic response in vivo has not been characterized. To define the role of platelet-derived NO in vivo, we studied mice that lacked a functional eNOS gene (NOSIII). Surface P-selectin expression in platelets from eNOS-deficient mice was not significantly altered; however, bleeding times were markedly decreased in eNOS-deficient versus wild-type mice (77.2+/-3 versus 133.4+/-3 seconds, P<0.00005). To determine the contribution of endothelium- versus platelet-derived NO to the bleeding time, isolated platelets from either eNOS-deficient or wild-type mice were transfused into a thrombocytopenic eNOS-deficient mouse and the bleeding time was measured. The bleeding times in mice transfused with eNOS-deficient platelets were significantly decreased compared with mice transfused with wild-type platelets (Deltableeding time, -24.6+/-9.1 and -3.4+/-5.3 seconds, respectively; P<0.04). Platelet recruitment was studied by measuring serotonin release from a second recruitable population of platelets that were added to stimulated platelets at the peak of NO production. There was 40.3+/-3.7% and 52. 0+/-2.1% serotonin release for platelets added to wild-type or eNOS-deficient platelets, respectively (P<0.05). In summary, mice that lacked eNOS had markedly decreased bleeding times even after endothelial NO production was controlled. These data suggest that the lack of platelet-derived NO alters in vivo hemostatic response by increasing platelet recruitment. Thus, these data support a role for platelet-derived NO production in the regulation of hemostasis.  (+info)

Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production. (5/411)

1. The effects of ethyl alcohol and wine (red and white) on haemostatic parameters and experimental thrombosis were studied in rats; NO was evaluated as a possible mediator of these effects. 2. We found that red wine (12% alcohol) supplementation (8.4 +/- 0.4 ml d-1 in drinking water, for 10 days) induced a marked prolongation of 'template' bleeding time (BT) (258 +/- 13 vs 132 +/- 13 s in controls; P < 0.001), a decrease in platelet adhesion to fibrillar collagen (11.6 +/- 1.0 vs 32.2 +/- 1.3%; P < 0.01) and a reduction in thrombus weight (1.45 +/- 0.33 vs 3.27 +/- 0.39 mg; P < 0.01). 3. Alcohol-free red wine showed an effect similar to red wine. In contrast, neither ethyl alcohol (12%) nor white wine (12% alcohol) affected these systems. 4. All these effects were also observed after red wine i.v. injection (1 ml kg-1 of 1:4 dilution) 15 min before the experiments. 5. The effects of red wine were prevented by the NO inhibitor, N omega nitro-L-arginine-methyl ester (L-NAME). L-arginine, not D-arginine, reversed the effect of L-NAME on red wine infusion. 6. Red wine injection induced a 3 fold increase in total radical-trapping antioxidant parameter values of rat plasma with respect to controls, while white wine and alcohol did not show any effect. 7. Our study provides evidence that red wine modulates primary haemostasis and prevents experimental thrombosis in rats, independently of its alcohol content, by a NO-mediated mechanism.  (+info)

Magnitude and time course of impaired primary haemostasis after stopping chronic low and medium dose aspirin in healthy volunteers. (6/411)

Aspirin ingestion within the previous 7-10 days is often considered a relative contraindication to performing invasive procedures. However, aspirin is an important component of many patients' treatment and withholding therapy for this time may be dangerous. To measure both the magnitude of the impairment in primary haemostasis induced by aspirin and how much recovery of platelet function occurs within 48 h of stopping aspirin, we studied serial changes in bleeding time (BT) in a randomized, double-blind, placebo-controlled study. Fifty-two healthy volunteers had BT performed before and at 2, 9, 24 and 48 h after a 7-day course of either aspirin 75 mg, 300 mg or placebo. The main outcome recorded was BT at each time. Nearly 25% of subjects had extended BT to more than 10 min, but no BT were greater than 10 min, 48 h after stopping aspirin. There was a small but statistically significant (P < 0.01) difference between the 48-h and baseline BT in both aspirin groups (49 and 64 s in the 75 mg and 300 mg groups, respectively). There was no difference in the magnitude or time course of effect between low and medium dose aspirin (P = 0.392 and P = 0.797, respectively). We conclude that despite considerable inter-individual variability in the magnitude of aspirin effect on primary haemostasis, the time course of effect was consistent. In healthy volunteers, the defect in primary haemostasis had largely disappeared 48 h after the last dose.  (+info)

Neither endogenous nor inhaled nitric oxide influences the function of circulating platelets in healthy volunteers. (7/411)

Experimental models have indicated prothrombotic effects of inhibition of nitric oxide (NO) production, and anti-thrombotic effects of inhaled NO, but the influence of NO on platelet function in vivo in humans is not well established. We therefore investigated the effects of systemic inhibition of NO synthesis by N(G)-monomethyl-L-arginine (L-NMMA) and of NO inhalation on platelet function in vivo. On two occasions, L-NMMA (13.5 mg/kg) or saline infusion was administered to 14 healthy volunteers in a double-blind cross-over study. After a 30 min infusion of L-NMMA or placebo, NO inhalation (30 p.p.m) was added during the remaining 30 min of infusion, on both occasions. Measurements included filtragometry ex vivo (reflecting platelet aggregability), flow-cytometric evaluation of platelets in whole blood (fibrinogen binding and P-selectin expression), plasma beta-thromboglobulin (reflecting platelet secretion), cGMP in platelets and plasma, thrombin generation markers (thrombin fragment 1+2 and thrombin-antithrombin complexes) in plasma, and bleeding time. L-NMMA increased blood pressure and decreased heart rate. NO inhalation did not influence blood pressure or heart rate, but caused a 3-fold elevation in plasma cGMP levels (P<0.001). Neither L-NMMA nor NO influenced filtragometry readings or flow-cytometric determinations of platelet fibrinogen binding and P-selectin expression. Furthermore, plasma beta-thromboglobulin, platelet cGMP and thrombin generation markers were not influenced by either treatment. Bleeding time was not influenced by L-NMMA compared with placebo, but was increased by approximately 25% during NO inhalation (P<0.01), whether NO synthesis had been inhibited or not. The prolongation of bleeding time by inhaled NO was not accompanied by any effect on the platelet variables assessed. The present results indicate that circulating platelets are not influenced by endogenous or inhaled NO, presumably due to the rapid inactivation of NO in the blood. This does not exclude possible effects of endothelial NO in the interface between the blood and the vessel wall.  (+info)

Prognostic value of serum hepatocyte growth factor in patients with acute coronary syndromes. (8/411)

The present study examined whether or not hepatocyte growth factor (HGF), an endothelium-specific growth factor that stimulates regeneration of the endothelium, is increased or has a prognostic significance in patients with acute coronary syndromes. HGF was measured in 106 patients with coronary artery disease (20 stable effort angina, 12 unstable angina without adverse events, 24 unstable angina with adverse events and 50 acute myocardial infarction) on admission and 21 normal volunteers. The measurements in all patients were recorded before administration of heparin, and in acute myocardial infarction patients they were recorded from days 2 to 6 after heparin discontinuation on day 1. HGF levels (ng/ml) were 0.30+/-0.06 for the controls, 0.31+/-0.08 for stable effort angina patients, 0.31+/-0.08 for unstable angina patients without adverse events, 0.40+/-0.20 for unstable angina patients with adverse events and in acute myocardial infarction patients they were 0.45+/-0.18 on day 0, 0.57+/-0.45 on day 2, 0.50+/-0.35 on day 3, 0.48+/-0.32 on day 4, 0.44+/-0.20 on day 5, and 0.38+/-0.14 on day 6. HGF plays a crucial role in the restoration of injured endothelial cells and is a predictor of adverse events in patients with acute coronary syndromes.  (+info)

GASTRIC-MUCOSAL BLEEDING-TIME IN CIRRHOSIS - UCL DiscoveryGASTRIC-MUCOSAL BLEEDING-TIME IN CIRRHOSIS - UCL Discovery
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
http://discovery.ucl.ac.uk/56468/
AID 698773 - Antithrombotic activity in Sprague-Dawley rat arteriovenous shunt model assessed as reduction of thrombus dry...AID 698773 - Antithrombotic activity in Sprague-Dawley rat arteriovenous shunt model assessed as reduction of thrombus dry...
BioAssay record AID 698773 submitted by ChEMBL: Antithrombotic activity in Sprague-Dawley rat arteriovenous shunt model assessed as reduction of thrombus dry weight at 30 mg/kg, po qd for 5 consecutive days.
https://pubchem.ncbi.nlm.nih.gov/bioassay/698773
DZ-313 New Head Strap with 360° Rotation Mount Adapter EVATH-340234 - TinyDeal
Click to buy DZ-313 New Head Strap with 360° Rotation Mount Adapter EVATH-340234 from TinyDeal.com with wholesale price and free shipping!
https://www.tinydeal.com/dz-313-new-head-strap-with-360-rotation-mount-adapter-p-137237.html
Thrombosis & Hemostasis] Bleeding Disorders
Bleeding disorders can be subdivided into three categories, including: Primary hemostasis disordersSecondary hemostasis disordersFibrinolysis disorders
http://forum.tomhsiung.com/board-of-pharmacy-specialties-and-pharmacy-practice/hematology-and-oncology-pharmacy/1002-bleeding-disorders.html?s=63319314acacc9f3d5689ddda82d0ff0
Thrombosis & Hemostasis] Bleeding Disorders
Bleeding disorders can be subdivided into three categories, including: Primary hemostasis disordersSecondary hemostasis disordersFibrinolysis disorders
http://forum.tomhsiung.com/board-of-pharmacy-specialties-and-pharmacy-practice/hematology-and-oncology-pharmacy/1002-bleeding-disorders.html?s=0946a5158ef4587f57e5813cfb24118e
How the hemostatic function points to design
How the hemostatic function points to design Platelets have been mostly thought of as a fragment of a cell that stops bleeding and not much else. They can, also
http://reasonandscience.heavenforum.org/t2294-how-the-hemostatic-function-points-to-design
Búsqueda | Portal Regional de la BVSBúsqueda | Portal Regional de la BVS
BACKGROUND AND PURPOSE: We aimed to examine perfusion changes between 3 and 6 and 6 and 24 hours after stroke onset and their impact on tissue outcome. METHODS: Acute ischemic stroke patients underwent perfusion magnetic resonance imaging at 3, 6, and 24 hours after stroke onset and follow-up fluid-attenuated inversion recovery at 1 month to assess tissue fate. Mean transit time prolongation maps (MTTp=MTT-[median MTT of contralateral hemisphere]) were obtained at 3 (MTTp3 h), 6 (MTTp6 h), and 24 hours (MTTp24 h). Perfusion changes between 3 and 6 hours (ΔMTTp3_6) and 6 and 24 hours (ΔMTTp6_24) were calculated. A 2-step analysis was performed to evaluate the impact of ΔMTTp3_6 and ΔMTTp6_24 on tissue fate. First, a voxel-based multivariable logistic regression was performed for each individual patient with MTTp3 h, ΔMTTp3_6, and ΔMTT6_24 as independent variables and tissue fate as outcome. Second, Wilcoxon signed-rank tests on logistic regression coefficients were performed across patients ...
https://pesquisa.bvsalud.org/portal/?lang=es&q=mh:%22Angiograf%C3%ADa%20por%20Resonancia%20Magn%C3%A9tica/tendencias%22
Primary Hemostasis - AMA Manual of StylePrimary Hemostasis - AMA Manual of Style
Note the typography of the following terms, which are found in descriptions of platelet hemostasis (use parenthetical abbreviated terms in accordance with , Abbreviations, Clinical, Technical, and Other Common Terms): See also , Blood Groups, Platelet Antigens, and Granulocyte Antigens, Platelet-Specific Antigens. |
http://www.amamanualofstyle.com/view/10.1093/jama/9780195176339.001.0001/med-9780195176339-div2-422?rskey=MsD2ud&result=4&q=
Primary Hemostasis - AMA Manual of StylePrimary Hemostasis - AMA Manual of Style
Note the typography of the following terms, which are found in descriptions of platelet hemostasis (use parenthetical abbreviated terms in accordance with , Abbreviations, Clinical, Technical, and Other Common Terms): See also , Blood Groups, Platelet Antigens, and Granulocyte Antigens, Platelet-Specific Antigens. |
http://www.amamanualofstyle.com/view/10.1093/jama/9780195176339.001.0001/med-9780195176339-div2-422?rskey=foxwqS&result=1&q=
Selected publications - Institute of Basic Medical Sciences
OKennedy, N., Crosbie, L., van Lieshout M., Broom J.L.. Webb D. and Duttaroy, A.K. (2006) Antiplatelet activity of tomato extract. Part I: Effects on platelet function in vitro and ex vivo - a time course cannulation study in healthy humans, Am. J. Clin Nutr 84:570-579 ...
http://www.med.uio.no/imb/english/research/groups/nutrition-chronic-diseases/publications/
Reviparin sodium | SpringerLinkReviparin sodium | SpringerLink
Pathania YS, et al. Acral hemorrhagic blisters induced by reviparin. International Journal of Dermatology 58: 1329-1330, No. 11, Nov 2019. Available from: URL: http://doi.org/10.1111/ijd.14406 - IndiaCrossRefGoogle Scholar ...
https://link.springer.com/article/10.1007%2Fs40278-019-71789-0
Surgical Hemostasis and Clotting Mechanisms | Ento Key
Introduction Print Section Listen The most important considerations for maintaining surgical hemostasis begin before the operation starts. This chapter provides practical tools to approach patients before, during, and after the surgical procedure. Below is a summary explanation of normal hemostasis, and how it can be conceptualized into four basic components. Explanations are provided to illustrate…
https://entokey.com/surgical-hemostasis-and-clotting-mechanisms/
Continuous infusion of factor VIII concentrate to a patient with severe von Willebrand disease. - Semantic ScholarContinuous infusion of factor VIII concentrate to a patient with severe von Willebrand disease. - Semantic Scholar
Semantic Scholar extracted view of Continuous infusion of factor VIII concentrate to a patient with severe von Willebrand disease. by José Bruno Montoro et al.
https://www.semanticscholar.org/paper/Continuous-infusion-of-factor-VIII-concentrate-to-Montoro-Altisent/d0c3798bc1348380ae42acdc7fda533c7df6db01
Impairment of primary haemostasis by low molecular weight heparins in rats<...
TY - JOUR. T1 - Impairment of primary haemostasis by low molecular weight heparins in rats. AU - Borowska, A.. AU - Lauri, D.. AU - Maggi, A.. AU - Dejana, E.. AU - De Gaetano, G.. AU - Donati, M. B.. AU - Pangrazzi, J.. PY - 1988. Y1 - 1988. N2 - Different low molecular weight (LMW) heparins were tested on primary haemostasis in rats. Four preparations were studied; one was devoid of any effect on the bleeding time, while the other three prolonged the bleeding time to varying extents. As a consequence we studied the effect of these heparins on platelet aggregation. The fractions which prolonged the bleeding time, also inhibited the ex vivo and in vitro platelet aggregation, whereas the one devoid of any effect on the bleeding time did not affect platelet aggregation. Similar results were obtained using both platelet-rich plasma (PRP) and gel-filtered platelets. The in vitro response of platelets to aggregating agents may offer a parameter to detect the presence of bleeding factor(s) in some ...
https://moh-it.pure.elsevier.com/en/publications/impairment-of-primary-haemostasis-by-low-molecular-weight-heparin
Local proCPU (TAFI) activation during thrombolytic treatment in a dog model of coronary artery thrombosis be inhibited with a...Local proCPU (TAFI) activation during thrombolytic treatment in a dog model of coronary artery thrombosis be inhibited with a...
Local proCPU (TAFI) activation during thrombolytic treatment in a dog model of coronary artery thrombosis be inhibited with a direct, small molecule thrombin inhibitor (melagatran) ...
https://repository.uantwerpen.be/link/irua/40055
Effect of Selective or Combined Inhibition of Integrins αIIbβ3 and αvβ3 on Thrombosis and Neointima After Oversized Porcine...Effect of Selective or Combined Inhibition of Integrins αIIbβ3 and αvβ3 on Thrombosis and Neointima After Oversized Porcine...
We describe the first comparison of the effects of antagonists of different integrins on the arterial response to injury. These data indicate that continuous infusions of antagonists of either αIIbβ3 or αvβ3, started before and continued for 2 weeks after porcine PTCA, significantly reduce neointima formation at 28 days. αIIbβ3 inhibitors had marked effects on platelet aggregation and thrombus formation 6 hours after PTCA, whereas a selective αvβ3 inhibitor showed no effect. Equally, the αvβ3 inhibitors were able to inhibit VSMC adhesion, a property not shared by the selective αIIbβ3 inhibitor, although final reductions in neointima were comparable between the 3 treatment groups.. Both αIIbβ3 inhibition and combined αIIbβ3/αvβ3 inhibition induced rapid inhibition of ex vivo platelet aggregation, translating into concomitant reductions in adherent thrombus. Measurement of ex vivo platelet aggregation may overestimate the degree of platelet inhibition, and the relevance of this ...
http://circ.ahajournals.org/content/103/8/1135
Large Amounts of Vascular Endothelial Growth Factor at the Site of Hemostatic Plug Formation In Vivo | Arteriosclerosis,...Large Amounts of Vascular Endothelial Growth Factor at the Site of Hemostatic Plug Formation In Vivo | Arteriosclerosis,...
There is evidence from recent studies that VEGF is stored in human megakaryocytes and is released from platelets on stimulation with thrombin.14 15 These studies were performed under in vitro conditions in the absence of important determinants of in vivo clotting such as the vessel wall, blood flow, and clotting proteases. Thus, it is uncertain if their in vitro observations are of relevance for the in vivo circumstances. The technique applied in our study covers many mechanisms relevant for hemostatic plug formation in vivo. It is performed directly on human subjects and takes into account the interaction between blood cells, endothelium, and various plasma proteins under physiological flow conditions. Thus, we believe that the experimental approach applied in this study is appropriate for investigating the mechanisms important for plug formation under conditions close to the in vivo circumstances.. The principal finding of our study was that much higher concentrations of VEGF are detectable in ...
http://atvb.ahajournals.org/content/19/7/1757
Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH -...Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH -...
Bodó, I. and Eikenboom, J. and Montgomery, R. and Patzke, J. and Schneppenheim, R. (2015) Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13 (7). pp. 1345-1350. ISSN 1538-7933 ...
http://real.mtak.hu/83625/
北京大学医学部机构知识库([email protected]): Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of...
In the nanoscale assembly-based design of antithrombotic agents, poly-alpha,beta-DL-aspartyl-L-arginine (MW: 20 741) was prepared. from the thermal polycondensation of DL-aspartic acid and the amidation of polysuccimide with L-arginine. In the pH environments corresponding to the stomach (pH 1.2), intestinal tract (pH 7.6), blood and tissue fluids (pH 7.4) 4.8 x 10(4,2,-4,-6,-8) nM of poly-alpha,beta-DL-aspartyl-L-arginine assembled to form diverse nano-species. The sizes of the smallest nanoparticle, nanobell and nanomango were less than 100 nm. At the oral doses of 0.72, 1.44 and 2.89 mu mol kg(-1), poly-alpha,beta-DL-aspartyl-L-arginine dose-dependently inhibited the ex vivo platelet aggregation and the in vivo thrombosis of the treated rats. By assembling to form diverse nano-species, the absorption of oral poly-alpha,beta-DL-aspartyl-L-arginine in the stomach and intestinal tract could be assisted. ...
http://ir.bjmu.edu.cn/handle/400002259/65816
Ehlers-Danlos syndrome with Platelet Dysfunction from Fibronectin Abnormality Symptoms, Diagnosis, Treatments and Causes -...Ehlers-Danlos syndrome with Platelet Dysfunction from Fibronectin Abnormality Symptoms, Diagnosis, Treatments and Causes -...
Ehlers-Danlos syndrome with Platelet Dysfunction from Fibronectin Abnormality information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
http://www.rightdiagnosis.com/e/ehlers_danlos_syndrome_with_platelet_dysfunction_from_fibronectin_abnormality/intro.htm
Platelet Dysfunction - Blood Disorders - Merck Manuals Consumer VersionPlatelet Dysfunction - Blood Disorders - Merck Manuals Consumer Version
Platelet Dysfunction - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.
https://www.merckmanuals.com/home/blood-disorders/platelet-disorders/platelet-dysfunction
Sparrho | Acquired platelet dysfunction.Sparrho | Acquired platelet dysfunction.
Acquired platelet dysfunction is encountered frequently in clinical practice. The usual clinical presentation is that of mucosal bleeding, epistaxis, or superfi
https://www.sparrho.com/item/acquired-platelet-dysfunction/762885/
A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously...A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously...
Haemostatic effect of N8-GP when used for treatment of bleeding episodes and assessed as: Excellent, Good, Moderate, or None [ Time Frame: For the main phase (from 0-26 weeks of treatment) and the extension phase of the trial (from 26 weeks to the last patient has completed the trial ...
https://clinicaltrials.gov/ct2/show/NCT01731600?term=Hemophilia%3A+Clinical+Trials&rank=14
A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously...A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously...
Haemostatic effect of N8-GP when used for treatment of bleeding episodes and assessed as: Excellent, Good, Moderate, or None [ Time Frame: For the main phase (from 0-26 weeks of treatment) and the extension phase of the trial (from 26 weeks to the last patient has completed the trial ...
https://clinicaltrials.gov/ct2/show/NCT01731600?term=Hemophilia%3A+Clinical+Trials&rank=10
Antithrombotic HerbsAntithrombotic Herbs
Herbs for Antithrombotic. Definition of Antithrombotic Herbs. List of most effective herbs used as Antithrombotic in repertory format. Combinations of herbs are more effective than single herbs.
https://herbpathy.com/Action-of-Antithrombotic-Cid517
Prognostic role of plasma von Willebrand factor and soluble E-selectin levels for future cardiovascular events in a real-world...Prognostic role of plasma von Willebrand factor and soluble E-selectin levels for future cardiovascular events in a real-world...
BACKGROUND: Endothelial damage/dysfunction may contribute to a prothrombotic state in patients with atrial fibrillation (AF) and the increased risk of thromboembolism and cardiovascular events. Raised plasma von Willebrand factor (vWf), an established marker of endothelial damage/dysfunction, has been associated with stroke and vascular events, at least in a clinical trial population. Soluble E-selectin (sE-sel) is another biomarker of endothelial activation/dysfunction, with more limited data on prognostic outcomes in AF.. OBJECTIVE: To assess the relationship between the levels of vWf, sE-sel and clinical adverse outcomes (including stroke, MI and all-cause mortality) in a real-world community cohort of patients with AF.. METHODS: We studied 423 patients (mean age 72·7 ± 8·4 years, 55·6% male) with nonvalvular AF, with a median follow-up of 19 (9-31) months. Plasma vWf and sE-sel levels were measured using enzyme-linked immunosorbent assay (ELISA).. RESULTS: There were 94 clinical ...
https://read.qxmd.com/read/23961715/prognostic-role-of-plasma-von-willebrand-factor-and-soluble-e-selectin-levels-for-future-cardiovascular-events-in-a-real-world-community-cohort-of-patients-with-atrial-fibrillation
Von Willebrands DiseaseVon Willebrands Disease
Platelets play a vital role in the blood-clotting process. One of the most common veterinary problems encountered with regard to platelets is von Willebrands disease (vWD), a disorder in dogs that is characterized by excessive bleeding due to a defect in platelet function ...
http://www.pethealthnetwork.com/tags/von-willebrands-disease
Two new candidate mutations in type IIA von Willebrands disease (Arg834--|Gly, Gly846--|Arg) and one polymorphism (Tyr821--...Two new candidate mutations in type IIA von Willebrands disease (Arg834--|Gly, Gly846--|Arg) and one polymorphism (Tyr821--...
Recently, several von Willebrand factor gene mutations resulting in type IIA von Willebrands disease have been reported. We examined 8 patients from Sweden and Denmark with this phenotype and found two new candidate mutations and a hitherto unknown amino acid polymorphism. One patient had a de novo occurring mutation resulting in substitution of glycine for arginine 834. Previous reports have demonstrated conversion of arginine 834 to tryptophan or glutamine in IIA patients. A 2nd patient had a G(4825)--|A transition, substituting arginine for glycine 846. The transition produces a sequence congruent with that of the pseudogene but several lines of evidence indicate that a sequencing error due to influence by the latter could be excluded. The remaining 6 patients had one of the earlier described substitution mutations: Ser743--|Leu and Ile865--|Thr. In addition, two sequence variations not linked to the phenotype were found, namely Tyr821--|Cys and Val802--|Leu.
https://www.semanticscholar.org/paper/Two-new-candidate-mutations-in-type-IIA-von-Willeb-Donn%C3%A9r-Kristoffersson/5c7017779a42ce386676f17bbf626c42d97a089d
Pharmacokinetic studies on Wilfactin((R)), a von Willebrand factor concentrate with a low factor VIII content treated with...Pharmacokinetic studies on Wilfactin((R)), a von Willebrand factor concentrate with a low factor VIII content treated with...
Objective: In order to correct the primary von Willebrand factor (VWF) defect and avoid supra-physiologic plasma levels of factor VIII, a pure VWF concentrate almost devoid of FVIII was developed and used in France since 1989. Methods: The pharmacokinetic (PK) profile of the most recent version of this concentrate (Wilfactin®; LFB, Les Ulis, France), treated with three virus-inactivation/removal methods (solvent/detergent, 35 nm filtration, dry heat treatment), was investigated in 25 patients. Seventeen patients with various types of clinically severe von Willebrand disease (VWD) were included in a crossover, randomized trial carried out in five European centers and comparing Wilfactin® with concentrates containing both FVIII and VWF (FVIII/VWF). Eight type 3 VWD patients were included in another trial carried out in six French centers comparing Wilfactin® with its previous version (Facteur Willebrand-LFB®; LFB) that adopted one virus-inactivation method only. Results: For both the ...
https://air.unimi.it/handle/2434/17736
Von Willebrands DiseaseVon Willebrands Disease
Von Willebrands disease, a common bleeding disorder affecting males and females equally, is usually inherited as a dominant trait.
https://www.brainkart.com/article/Von-Willebrand---s-Disease_32012/
Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta...Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta...
Prediction of major adverse cardiovascular events (MACEs) may offer great benefits for patients with coronary artery disease (CAD). Von Willebrand factor (vWF) is stored in endothelial cells and released into blood plasma upon vascular dysfunction. This meta-analysis was performed to evaluate the prognostic value of plasma vWF levels in CAD patients with MACEs. A total of 15 studies were included in this meta-analysis through the search in PubMed, Embase and CNKI. Data were collected from 960 patients who had MACEs after CAD and 3224 controls nested without the adverse events. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random-effects model. The plasma vWF levels examined at 24 h and 48 h after admission were significantly higher in CAD patients with MACEs than those without. The pooled SMD among the MACEs group and the non-MACEs group was 0.55 (95% CI = 0.30-0.80, P | 0.0001) and 0.70 (95% CI = 0.27-1.13, P = 0.001), respectively. However, no
https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01375-7
Acquired von Willebrands syndrome: a single institution experienceAcquired von Willebrands syndrome: a single institution experience
Acquired von Willebrands disease or syndrome (AVWS) is a rare bleeding disorder distinguished from congenital von Willebrands disease by age at presentation and absence of personal and family history of bleeding disorders. We report on 22 patients with AVWS seen over 25 years. Mean age at diagnosi …
https://pubmed.ncbi.nlm.nih.gov/12666134/?dopt=Abstract
Safety and Antithrombotic Efficacy of Moderate Platelet Count Reduction by Thrombopoietin Inhibition in Primates | Science...Safety and Antithrombotic Efficacy of Moderate Platelet Count Reduction by Thrombopoietin Inhibition in Primates | Science...
Most heart attacks and strokes are caused by blood clots (thrombi) that block the vasculature. Because disease-causing arterial thrombosis depends on blood platelets, platelet inhibitors such as aspirin and clopidogrel effectively decrease the risk of thrombosis; however, they also impair platelet-dependent hemostasis that staunches bleeding from wounds and can therefore produce excessive bleeding. Experimental studies show that a reduction in the number of platelets also inhibits thrombosis, but these treatments also interfere with platelet function. Because normal hemostasis requires that the platelet concentration remain within a physiological range in the circulation, we evaluated whether lowering the number of circulating platelets-but only to a value still within the normal range-by inhibiting platelet formation in the bone marrow inhibits acute thrombogenesis in baboons. We reduced the platelet count with an inhibitor against the megakaryocyte-promoting hormone thrombopoietin and then ...
https://stm.sciencemag.org/content/2/37/37ra45
Treatment of von Willebrands DiseaseTreatment of von Willebrands Disease
The drug desmopressin (1-deamine-8-D-arginine vasopressin [DDAVP]) has become a mainstay of therapy for most patients with mild von Willebrand disease.
http://www.medindia.net/patients/patientinfo/von-willebrand-disease-treatment.htm
Thromboregulation - WikipediaThromboregulation - Wikipedia
Thromboregulation is the series of mechanisms in how a primary clot is regulated. These mechanisms include, competitive inhibition or negative feedback. It includes primary hemostasis, which is the process of how blood platelets adhere to the endothelium of an injured blood vessel. Platelet aggregation is fundamental to repair vascular damage and the initiation of the blood thrombus formation. The elimination of clots is also part of thromboregulation. Failure in platelet clot regulation may cause hemorrhage or thrombosis. Substances called thromboregulators control every part of these events. One primary function of thromboregulation is the control of primary hemostasis, which is the platelet aggregation process. Some thromboregulators enhance platelet aggregation and some others inhibit the process. Platelet aggregation plays a critical role in the genesis of a resulting thrombus. Adhesion should remain local, but platelet aggregation must grow exponentially to form a platelet thrombus and ...
https://en.wikipedia.org/wiki/Thromboregulation
Von Willebrands disease: Types, symptoms, risk factors, and causesVon Willebrands disease: Types, symptoms, risk factors, and causes
Von Willebrand disease (vWD) is the most common inherited bleeding condition. It can also result from leukemia, lupus, and the use of some drugs. A person with vWD will bruise and bleed more easily than other people, because they lack a clotting factor. People with this condition must take certain precautions.
https://www.medicalnewstoday.com/articles/188979
Plus itPlus it
Dosing of mice with clopidogrel (50 mg/kg) completely inhibited ADP-induced ex vivo platelet aggregation and signaling (cAMP) and blocked all of the surface P2Y12 receptors on resting platelets. It is interesting to note that the same high dose of clopidogrel (50 mg/kg) prevented vascular occlusion but did not achieve the thrombotic profile associated with P2Y12 deficiency, whereas the direct-acting inhibitor elinogrel did recapitulate the profile of P2Y12(−/−) mice. Addition of elinogrel (1 mg/kg i.v.) to this clopidogrel regimen (50 mg/kg, 3 days) completely blocked the residual thrombosis, confirming that this process was mediated by P2Y12 receptors. On the basis of this data, we hypothesized that residual thrombosis observed in clopidogrel-treated mice might be due to an unblocked (intracellular) pool of P2Y12 exposed on the platelet surface after platelet activation in vivo. In this study, we demonstrated that an inducible pool of P2Y12 receptors exists in human and mouse platelets and ...
http://jpet.aspetjournals.org/content/339/1/54
Clinical features of von Willebrands DiseaseClinical features of von Willebrands Disease
Most patients with vWD have mild disease that may go undiagnosed until trauma or surgery occurs. Trauma or surgery may result in life-threatening bleeding in severely affected individuals.
http://www.medindia.net/patients/patientinfo/von-willebrand-disease-clinical-features.htm
What are the chances of passing von Willebrands disease on to my daughter? | BabyCenterWhat are the chances of passing von Willebrands disease on to my daughter? | BabyCenter
See what pediatric expert Dr. Suzanne Dixon has to say about passing on this inherited disorder that alters the bloods ability to clot.
https://www.babycenter.com/health/conditions/what-are-the-chances-of-passing-von-willebrands-disease-on-t_2708
AID 444449 - Anticoagulant activity against Sprague-Dawley rat arterial thrombosis model induced by topical application of...AID 444449 - Anticoagulant activity against Sprague-Dawley rat arterial thrombosis model induced by topical application of...
BioAssay record AID 444449 submitted by ChEMBL: Anticoagulant activity against Sprague-Dawley rat arterial thrombosis model induced by topical application of Fecl2.
https://pubchem.ncbi.nlm.nih.gov/bioassay/444449
New Author: Megan! :DNew Author: Megan! :D
Id like to go under the assumption that most of you know what Von Willebrands Disease is, but I realize that I wasnt very educated about it until recently and some of you reading this might not have VWD. VWD is a bleeding disorder with 3 types caused by a lack of the Von Willebrand Factor in your blood. The factor helps clot your blood and also carries factor 8 through your blood. In type 1, you simply dont have enough of it. In type 2, you also dont have enough of it, but there are several sub-types of type 2. I would try to further explain type 2, but it is highly complicated and given that I have type 1, I dont fully understand it. Type 3 is the most severe type of VWD, in this case, you do not have any of the Von Willebrand factor circulating through your blood. It is very rare to have type 3 because both of your parents must have VWD, of any type, in order for you to have type 3. And even if both of your parents have VWD, it doesnt mean youll end up with type 3 or VWD at all ...
http://girlswithbleedingdisorders.blogspot.com/2012/04/hi-my-name-is-megan-and-as-contributor.html
Florence BallardFlorence Ballard
s body exhumed in order to prove her case. We were told that my sister had died of coronary artery thrombosis, but she didnt have a history of heart disease, she said this week. There was no trace of alcohol or barbiturates in her system, but there was this brown cereal-type substance which was never identified. I believe she was killed because someone wanted to silence her. But who? Maxine admits that she has privately confronted the man she suspects of being responsible for her sisters death. ...
http://whale.to/c/florence_ballard.html
How To Read A Blood Test Report - Abnormal Platelet Count - Beat Blood CancerHow To Read A Blood Test Report - Abnormal Platelet Count - Beat Blood Cancer
While your doctor will attempt to explain the various elements of a blood test report, it is advisable that all of us also understand the various elements of the report... after all, this is our life. And we should play an active role in our medical care.
https://beatbloodcancer.info/blog/how-to-read-a-blood-test-report-abnormal-platelet-count
MP0160,Diapharma,Platelet Function Testing,Diapharma,+,血小板功能检测,Array.Array.Array蚂蚁淘厂家直采.MP0160,Diapharma,Platelet Function Testing,Diapharma,+,血小板功能检测,Array.Array.Array蚂蚁淘厂家直采.
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Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis. | StrokeAntithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis. | Stroke
Platelet-fibrin thrombi in the lumen of atherostenotic carotid arteries may underlie transient ischemic attacks and cerebral infarction. For this reason, we investigated the antiplatelet and antithrombotic effects of a novel and potent platelet fibrinogen receptor (glycoprotein IIb/IIIa) antagonist (SK&F 106760).. The effects of 0.1-3.0 mg/kg i.v. SK&F 106760 on platelet aggregation were examined ex vivo in canine platelet-rich plasma (n = 20). In addition, the antithrombotic effects of SK&F 106760 were compared with those of aspirin in an acute canine model of extracranial carotid artery thrombosis with high-grade stenosis. Sham-operated (n = 4), vehicle-treated (n = 6), SK&F 106760-treated (n = 8), aspirin-treated (n = 9), and SK&F 106760+aspirin-treated (n = 5) dogs were examined.. The intravenous administration of SK&F 106760 caused a dose-related inhibition of ex vivo platelet aggregation. In the carotid artery thrombosis model, an occlusive thrombus formed at stenotic sites in the region ...
http://stroke.ahajournals.org/content/23/5/703
Ristocetin-induced aggregation of gel filtered platelets a study of von Willebrands disease and the effect of aspirin<...Ristocetin-induced aggregation of gel filtered platelets a study of von Willebrands disease and the effect of aspirin<...
TY - JOUR. T1 - Ristocetin-induced aggregation of gel filtered platelets a study of von Willebrands disease and the effect of aspirin. AU - Olson, John D.. AU - Fass, David N.. AU - Bowie, E. J.W.. AU - Mann, Kenneth G.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1974/2. Y1 - 1974/2. UR - http://www.scopus.com/inward/record.url?scp=49549158710&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=49549158710&partnerID=8YFLogxK. U2 - 10.1016/0049-3848(74)90103-0. DO - 10.1016/0049-3848(74)90103-0. M3 - Comment/debate. AN - SCOPUS:49549158710. VL - 4. SP - 383. JO - Thrombosis Research. JF - Thrombosis Research. SN - 0049-3848. IS - 2. ER - ...
https://scholars.uthscsa.edu/en/publications/ristocetin-induced-aggregation-of-gel-filtered-platelets-a-study--2
Cyclooxygenase-2-Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a SIRT1-Dependent...Cyclooxygenase-2-Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a SIRT1-Dependent...
Background-Selective inhibitors of cyclooxygenase-2 (COX-2) increase the risk of myocardial infarction and thrombotic events, but the responsible mechanisms are not fully understood. Methods and Results-We found that ferric chloride-induced arterial thrombus formation was significantly greater in COX-2 knockout (KO) compared to wild type (WT) mice. Cross-transfusion experiments excluded the likelihood that COX-2KO platelets, despite enhanced aggregation responses to collagen and thrombin, are responsible for increased arterial thrombus formation in COX-2KO mice. Importantly, we observed that COX-2 deletion decreased prostacyclin (PGI2) synthase and production, proliferator-activated receptor (PPAR)δ and sirtuin-1 (SIRT1) expression, with consequent increased upregulation of tissue factor (TF), the primary initiator of blood coagulation. Treatment of WT mice with a PGI2 receptor (IP) antagonist or a PPARδ antagonist, which predisposes to arterial thombosis, decreased SIRT1 expression and ...
http://circ.ahajournals.org/content/early/2012/08/03/CIRCULATIONAHA.112.097295
Effects of congestive heart failure on plasma von Willebrand factor and soluble P-selectin concentrations in patients with non...Effects of congestive heart failure on plasma von Willebrand factor and soluble P-selectin concentrations in patients with non...
vWf is one of several endothelium derived haemostatic mediators, with key roles in platelet aggregation and stabilisation of circulating clotting factors.17 Large quantities of vWf are stored in the Weibel-Palade bodies of endothelial cells and can be mobilised rapidly after endothelial cell activation18 to result in transient increases of plasma vWf.10 In experimental models at least, endothelial dysfunction has been shown to promote thrombosis, vasospasm, and vessel occlusion.19 One recent study found increased concentrations of immunoreactive vWf in the endothelium over the endocardial cells lining the surface of human left atrial appendage in patients with cardiac disease and further found thrombus formation over sites exhibiting impaired endothelial function.20. Thus, persistently increased concentrations of vWf and endothelial damage and dysfunction pose a real risk to thrombosis. Indeed, our recent cross sectional study suggests a relation between vWf and risk stratification for stroke ...
http://heart.bmj.com/content/91/6/759
Platelet function after cardiac surgery and its association with severe postoperative bleeding: the PLATFORM study<...
TY - JOUR. T1 - Platelet function after cardiac surgery and its association with severe postoperative bleeding. T2 - the PLATFORM study. AU - for The Surgical and Clinical Outcome Research (SCORE) Group. AU - Ranucci, Marco. AU - Pistuddi, Valeria. AU - Di Dedda, Umberto. AU - Menicanti, Lorenzo. AU - De Vincentiis, Carlo. AU - Baryshnikova, Ekaterina. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Platelet dysfunction after cardiac surgery is a determinant of postoperative bleeding. The existing guidelines suggest the use of desmopressin and/or platelet concentrate transfusions in case of platelet dysfunction in bleeding patients, but no cut-off values for platelet activity exist in the literature. The Platelet Function in the Operating Room (PLATFORM) study aims to identify the relationship between platelet function after cardiopulmonary bypass and severe bleeding, finding adequate predictive values of platelet function for severe bleeding. The PLATFORM is a prospective cohort study on 490 adult patients ...
https://moh-it.pure.elsevier.com/en/publications/platelet-function-after-cardiac-surgery-and-its-association-with-
Effect of Circulating Epinephrine on Platelet Function and Hematocrit | HypertensionEffect of Circulating Epinephrine on Platelet Function and Hematocrit | Hypertension
We studied a broad spectrum of platelet function parameters. Together with a low analytical variability for the various tests, a homogenous group of study subjects, and strictly standardized study conditions, these parameters would give a high sensitivity for detecting effects of infused epinephrine on platelet function.. Platelet count increased progressively with increasing arterial epinephrine in both EDTA- and ACD-anticoagulated blood, and the weight of circulating platelets increased by 29%, indicating recruitment of platelets into the circulation. Platelet size increased significantly in EDTA and decreased in ACD. The difference between EDTA and ACD was significant for both platelet count and size, suggesting that epinephrine not only recruits platelets into the circulation but also induces some microaggregation in vivo or adhesion ex vivo. Platelet aggregation in vitro induced by epinephrine decreased after infusion of epinephrine compared with saline but did not change when stimulated ...
http://hyper.ahajournals.org/content/25/5/1096.full
Hemostasis and thrombosis-laboratory diagnosis and treatmentHemostasis and thrombosis-laboratory diagnosis and treatment
2018 Elsevier Inc. All rights reserved. Transfusion medicine physicians and laboratory scientists are confronted daily with hemostasis and thrombosis-related concerns as they select and administer blood components, coagulation factor concentrates, anticoagulants, and agents to manage anticoagulant therapy. This chapter provides an introduction and overview of hemostasis. Primary hemostasis focuses on platelet function and interactions with the vasculature, endothelium, and the coagulation mechanism. Secondary hemostasis focuses on the coagulation cascade and is subdivided into the extrinsic, intrinsic, and common enzymatic pathways. Coagulation also includes control systems such as protein C, protein S, and antithrombin, and fibrinolysis. Depending on the defect, hemostasis disorders may be congenital or acquired, resulting in hemorrhage or thrombosis. The questions in this chapter will explore normal hemostasis, disorders of hemostasis, and the laboratory assays that predict, identify, and ...
https://scholars.uab.edu/display/pub2037756
Gene expression modifications in Whartons Jelly mesenchymal stem cells promoted by prolonged in vitro culturing | BMC Genomics...Gene expression modifications in Whartons Jelly mesenchymal stem cells promoted by prolonged in vitro culturing | BMC Genomics...
It has been demonstrated that the umbilical cord matrix, represented by the Whartons Jelly (WJ), contains a great number of mesenchymal stem cells (MSCs), characterized by the expression of specific MSCs markers, shared by both human and animal models. The easy access to massive WJ amount makes it an attractive source of MSCs for cell-based therapies. However, as in other stem cell models, a deeper investigation of WJ-derived MSCs (WJ-MSCs) biological properties, probably modulated by their prolonged expansion and fast growth abilities, is required before their use in clinical settings. In this context, in order to analyze specific gene expression modifications occurring in WJ-MSCs, along with their culture prolongation, we investigated the transcriptomic profiles of WJ-MSCs after 4 and 12 passages of in vitro expansion by microarray analysis. Hierarchical clustering analysis of the data set originated from a total of 6 experiments revealed that in vitro expansion of WJ-MSCs up to 12 passages promote
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-635
Trying to conceive, have platelet dysfunction in blood, getting heavy periods. Will it be transferred to baby? - Doctors...Trying to conceive, have platelet dysfunction in blood, getting heavy periods. Will it be transferred to baby? - Doctors...
Question - Trying to conceive, have platelet dysfunction in blood, getting heavy periods. Will it be transferred to baby?. Ask a Doctor about Fertility monitor, Ask an OBGYN, Maternal and Fetal Medicine
http://www.healthcaremagic.com/questions/Trying-to-conceive-have-platelet-dysfunction-in-blood-getting-heavy-periods-Will-it-be-transferred-to-baby/281056
Correction of both prothrombin time and primary haemostasis by recombinant factor VII during therapeutic alcohol injection of...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.ndm.ox.ac.uk/publications/66600
Platelets suppress T cell immunity against cancerPlatelets suppress T cell immunity against cancer
T cells are isolated from a patients blood and retrained, or primed, to recognise tumour cells. They are then injected back into the patients bloodstream where they can now hunt and fight cancer.. There was some evidence that platelets might make cancer worse. For example, patients who have excessive clotting related to their cancer almost always have a worse prognosis, according to Li.. Over the years, it has become appreciated that platelets are doing more than just clotting, says Li.. The first clue that cancer-fighting T cells might be suppressed by the bodys own clotting system came when the researchers gave melanoma to mice with genetically defective platelets.. Melanoma tumours grew much more slowly and primed T cells were much more active than in mice with normal platelets.. Next, the team isolated platelets and T cells from blood drawn from humans and mice.. In both cases, platelets with activated clotting activity suppressed T cell response.. It then used mass spectrometry to ...
http://oncologynews.com.au/platelets-suppress-t-cell-immunity-against-cancer/
KAKEN - Research Projects | Mechanism of Platelet Dysfunction during Cardiopulmonary Bypass and Effects of Heparincoated...KAKEN - Research Projects | Mechanism of Platelet Dysfunction during Cardiopulmonary Bypass and Effects of Heparincoated...
Principal Investigator：TANI Kazuhiro, Project Period (FY)：1996 - 1997, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Thoracic surgery
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671521/
World Thrombosis Day | Arterial ThrombosisWorld Thrombosis Day | Arterial Thrombosis
Arterial thrombosis is much less common than venous thrombosis, although it poses similar risks. The veins are responsible for taking blood and oxygen to different sections of the body. The blood is normally subject to higher pressure when it is travelling in the veins and may be moving more quickly. It is therefore less likely to clot in the arteries. Whereas venous thromboses normally lead to swelling and fluid congestion in an area, arterial thrombosis can lead to body tissue becoming starved of blood and oxygen. This can eventually lead to necrosis of the tissue. A thrombosis or embolism in the coronary artery can cause a heart attack. If blood supply to the brain is disrupted, the patient may suffer a stroke. ...
https://www.worldthrombosisday.org/issue/arterial/thrombosis/
Blood Clotting Disorder Is Common, Treatable - tribunedigital-sunsentinelBlood Clotting Disorder Is Common, Treatable - tribunedigital-sunsentinel
Dear Dr. Donohue: When I was 15, I had surgery and had blood tests. My doctor said there was a problem. He discovered I have a bleeding problem called von Willebrands disease. I am now 16, and even
http://articles.sun-sentinel.com/1999-09-22/lifestyle/9909210495_1_blood-pressure-disease-von-willebrand
B01 - Platelet-dependent inflammation and functional recovery of ischaemic myocardium and brainB01 - Platelet-dependent inflammation and functional recovery of ischaemic myocardium and brain
Project B01 (Gawaz/Langer) explores the roles of platelet CXCL-chemokines and CXC-receptors on thrombo-inflammation following organ ischemia (heart and brain). Further, the importance of platelet-CXCL/CXCR-axis for recovery of the failing ischemic myocardium using a variety of genetic mouse strains will be elaborated. We will mirror our experimental results with clinical studies of patients with acute myocardial ischemia. The project is aimed to develop novel therapeutic strategies for ischemic organ dysfunction with currently limited treatment options.. ...
https://www.platelets.eu/projects/b01-platelet-dependent-inflammation-and-functional-recovery-of-ischaemic-myocardium-and-brain/
Arterial Thrombosis Treatment In Pune - View Cost, Book Appointment Online | PractoArterial Thrombosis Treatment In Pune - View Cost, Book Appointment Online | Practo
Doctors for arterial thrombosis treatment in Pune, find doctors near you. Book Doctors Appointment Online, View Cost for Arterial Thrombosis Treatment in Pune | Practo
https://www.practo.com/pune/doctors-for-arterial-thrombosis-treatment
Congenital platelet function defectsCongenital platelet function defects
Congenital platelet function defects are conditions that prevent clotting elements in the blood, called platelets, from working as they should. Platelets help the blood clot. Congenital means present from birth.
https://www.baptistjax.com/health-library/disease/congenital-platelet-function-defects
WHOCC - ATC/DDD IndexWHOCC - ATC/DDD Index
Acetylsalicylic acid preparations specifically intended for use as antithrombotic agents are classified in this group. This exception from the basic principle of only one code for each route of administration is made because of the extensive use of acetylsalicylic acid both as an antithrombotic agent and as an analgesic. Whether an acetylsalicylic acid product should be classified in this group or in N02BA, should be decided at the national level based on the main indication of the product ...
https://www.whocc.no/atc_ddd_index/?code=B01AC19&showdescription=yes
WHOCC - ATC/DDD IndexWHOCC - ATC/DDD Index
Acetylsalicylic acid preparations specifically intended for use as antithrombotic agents are classified in this group. This exception from the basic principle of only one code for each route of administration is made because of the extensive use of acetylsalicylic acid both as an antithrombotic agent and as an analgesic. Whether an acetylsalicylic acid product should be classified in this group or in N02BA, should be decided at the national level based on the main indication of the product ...
https://www.whocc.no/atc_ddd_index/?code=B01AC15&showdescription=yes
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Apparatus and method for monitoring platelet function and drug response in a microfluidic-chip<...
TY - PAT. T1 - Apparatus and method for monitoring platelet function and drug response in a microfluidic-chip. AU - Lim, Chae Seung. PY - 2017/2/17. Y1 - 2017/2/17. N2 - 마이크로 유동칩 기반 혈소판 기능 및 약물반응 검사 장치 및 방법. AB - 마이크로 유동칩 기반 혈소판 기능 및 약물반응 검사 장치 및 방법. M3 - Patent. M1 - 6091648. ER - ...
https://koreauniv.pure.elsevier.com/en/publications/apparatus-and-method-for-monitoring-platelet-function-and-drug-re
Organization of Experimentally Induced Arterial Thrombosis in Rats From Two Weeks Until Ten Months. The Development of an...Organization of Experimentally Induced Arterial Thrombosis in Rats From Two Weeks Until Ten Months. The Development of an...
In a previous paper (1) the organization of an experimental arterial thrombus in rat aorta during the first six days was described. The present paper will set out the thrombus organization during the following weeks and months. Within one month, fibrin and platelets inside the thrombus disappear, an …
https://pubmed.ncbi.nlm.nih.gov/6661042/?dopt=Abstract
Products and solutions to improving treatment for thrombosis and Haemostasis : automatic analysers, reagents,... - StagoProducts and solutions to improving treatment for thrombosis and Haemostasis : automatic analysers, reagents,... - Stago
Diagnostica Stago, Inc., (DSI) is an industry leader in the science of hemostasis and thrombosis. Stago provides the total commitment of global resources and responsiveness, coupled with cutting edge technology and reliability. DSI is dedicated to continually developing and providing the very best hemostasis products, technical support, and services. ...
http://www.stago-us.com
About this file - European Patent Register
A] - M. L. VAN MONTFOORT ET AL, Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model, THROMBOSIS AND HAEMOSTASIS, DE, (20130808), vol. 110, no. 5, doi:10.1160/TH13-05-0429, ISSN 0340-6245, pages 1065 - 1073, XP055293624 [A] 1-48 * figure all; example all; table all ...
https://register.epo.org/application?number=EP17731444
2015 Strategies in the German Hemostasis Diagnostic Testing Market
2015 Strategies in the German Hemostasis Diagnostic Testing Market Published by VPGMarketResearch.com at researchbeam.com 406 Pages
https://www.researchbeam.com/2015-strategies-in-the-german-hemostasis-diagnostic-testing-market
Bambi Seamless Top | MayziaBambi Seamless Top | Mayzia
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Bleeding timeBleeding time
The time from when the incision is made until all bleeding has stopped is measured and is called the bleeding time. Every 30 ... The term template bleeding time is used when the test is performed to standardized parameters. The bleeding time test is a ... The time it takes for the bleeding to stop (i.e. the time it takes for a platelet plug to form) is measured. Cessation of ... Bleeding time is a medical test done on someone to assess their platelets function. It involves making a patient bleed, then ...
https://en.wikipedia.org/wiki/Bleeding_time
Bleeding Through (Once Upon a Time)Bleeding Through (Once Upon a Time)
Ihnat, Gwen (April 20, 2014). "ONCE UPON A TIME: "Bleeding Through"". The A.V. Club. Retrieved April 20, 2014. "Bleeding ... "Bleeding Through" is the eighteenth episode of the third season of the American fantasy drama series Once Upon a Time, and the ... "Once Upon a Time": Bleeding Through "Sunday Final Ratings: 'The Amazing Race' Adjusted Up; 'Dateline', 'American Dream Builders ... She reveals to Gold that she is planning to go back in time, and she offers to bring Gold back with her so he can be reunited ...
https://en.wikipedia.org/wiki/Bleeding_Through_(Once_Upon_a_Time)
No Time to BleedNo Time to Bleed
... '". heavymetal.about.com. Retrieved October 13, 2013. "No time to Bleed review". Allmusic. "No time to Bleed ... SUICIDE SILENCE - NO TIME TO BLEED (CD/DVD BODY BAG EDITION) CM Distro No Time to Bleed (Bonus Track Version) by Suicide ... No Time to Bleed review. Chronicles of Chaos No Time to Bleed review. Archived October 25, 2009, at the Wayback Machine Komodo ... No Time To Bleed (Body Bag Edition) Official Century Media website "Suicide Silence, 'No Time to Bleed' (Body Bag Edition) -- ...
https://en.wikipedia.org/wiki/No_Time_to_Bleed
No Time to Bleed (song)No Time to Bleed (song)
"No Time to Bleed" - 2:22 "No Time to Bleed (Big Chocolate Remix)" - 4:57 Suicide Silence Mitch Lucker - vocals Mark Heylmun - ... No Time To Bleed' Seven-Inch Single Blabbermouth Suicide Silence - No Time To Bleed (Single) Century Media (Articles with ... "No Time to Bleed" is a song by American deathcore band Suicide Silence. The song was released as the third and final single and ... drums Production Produced by Machine Artwork by Joshua Belanger No Time to Bleed - Single by Suicide Silence iTunes SUICIDE ...
https://en.wikipedia.org/wiki/No_Time_to_Bleed_(song)
The Bleeding (song)The Bleeding (song)
There was not a more opportune time to write a song like "The Bleeding." It's probably the most personal song I've ever written ... Cause at the time, you know, I had just separated from my ex-fiancee and with Motograter separating, it was a real tragic time ... Acoustic version - This version, known as "The Bleeding (Acoustic)" or "The Bleeding (Unplugged)" is a version of the song ... "The Bleeding" about, his ex-fiancé, was at the show. It was the first time Moody saw her in about a year. Moody spoke about it ...
https://en.wikipedia.org/wiki/The_Bleeding_(song)
Postcoital bleedingPostcoital bleeding
Some people will bleed after intercourse for the first time but others will not. The hymen may bleed if it is stretched since ... The bleeding can be from the uterus, cervix, vagina and other tissue or organs located near the vagina. Postcoital bleeding can ... Postcoital bleeding is bleeding from the vagina after sexual intercourse and may or may not be associated with pain. ... Postcoital bleeding may occur throughout pregnancy. The presence of cervical polyps may result in postcoital bleeding during ...
https://en.wikipedia.org/wiki/Postcoital_bleeding
The BledThe Bled
This also marked the first time The Bled left Arizona to tour as a band. The album demonstrated The Bled's skills in both a ... The Bled 2008 interview with TheGrixer.com The Bled interview at lambgoat.com Interview with James Munoz of The Bled The Bled ... During this time Pass the Flask went out of print. The Bled was unable to sell it on tour because it was released on their ... The Bled (2002) Split EPs Alexisonfire / The Bled The Bled / From Autumn to Ashes Non-album tracks Masters of Horror - "Nervous ...
https://en.wikipedia.org/wiki/The_Bled
Bleeding KansasBleeding Kansas
About 56 people, though, died in Bleeding Kansas by the time the violence ended in 1859. The congressional legislative deadlock ... Bleeding Kansas, Bleeding Missouri: The Long Civil War on the Border. Lawrence, KS: University Press of Kansas, 2013. Epps, ... Bleeding Kansas: Contested Liberty in the Civil War Era (2006) Goodrich, Thomas. War to the Knife: Bleeding Kansas, 1854-1861 ( ... Bleeding Kansas, Bloody Kansas, or the Border War was a series of violent civil confrontations in Kansas Territory, and to a ...
https://en.wikipedia.org/wiki/Bleeding_Kansas
Thine Eyes BleedThine Eyes Bleed
"Thine Eyes Bleed Get Better With Time". Chart Attack - March 11, 2008. "THINE EYES BLEED'S THINE EYES BLEED WILL MAKE THINE ... Thine Eyes Bleed is a Canadian melodic death metal band from London, Ontario. Thine Eyes Bleed took part in a US tour in 2004. ... In April 2008, Thine Eyes Bleed released their follow up album, Thine Eyes Bleed. Justin Wolfe later became a chef and opened ... Thine Eyes Bleed was managed by Morgan and Mercedes Lander's parents. Their father Dave Lander died of a heart attack on August ...
https://en.wikipedia.org/wiki/Thine_Eyes_Bleed
Comics anthologyComics anthology
"Dark Horse Presents, Cancelled One More Time…". Bleeding Cool News. Bleeding Cool News. Retrieved 13 February 2019. (Articles ...
https://en.wikipedia.org/wiki/Comics_anthology
Cory Kennedy (skateboarder)Cory Kennedy (skateboarder)
... bleeding all the time; slammed right on top of me; and we put him on the team anyway. Welcome to Fourstar Cory ... you dipshit ... Kennedy was uninjured; his blood alcohol level was approximately 0.10 at the time of the crash - over the state's legal limit ... Clarridge, C. (February 8, 2018). "Kennedy charged in Vashon Island crash that killed videographer". The Seattle Times. ... and advocated on Maigetter's behalf that Kennedy should not serve any prison time: "Preston would have wanted that his friend ...
https://en.wikipedia.org/wiki/Cory_Kennedy_(skateboarder)
The Bleeding HorseThe Bleeding Horse
"Who's that with you? I saw him a few times in the Bleeding Horse in Camden street with Boylan, the billsticker." "Dublin ... The Bleeding Horse is a pub on Upper Camden Street, Dublin, Ireland. It dates at least back to the 17th century, and was ... One is that when a horse got the "staggers" it was bled by a farrier at the inn. Another is that the name of the pub comes from ... The Bleeding Horse has been mentioned in several novels, including the Cock and Anchor (1845) by Sheridan Le Fanu and Ulysses ...
https://en.wikipedia.org/wiki/The_Bleeding_Horse
Juliette LewisJuliette Lewis
Ebert, Roger (February 4, 1994). "Romeo Is Bleeding". Chicago Sun-Times. Archived from the original on July 16, 2019. Ebert, ... Judy Berman of Time magazine gave the series an unfavorable review, writing that Lewis is "underutilized, as usual." Also in ... The film received unfavorable reviews, with A. O. Scott of The New York Times writing that both Taylor and Lewis "overact like ... Holden, Stephen (February 26, 1999). "FILM REVIEW; The Odds May Be Long, but You Can Bet on Love". The New York Times. Archived ...
https://en.wikipedia.org/wiki/Juliette_Lewis
List of Juliette Lewis performancesList of Juliette Lewis performances
Ebert, Roger (February 4, 1994). "Romeo Is Bleeding". Chicago Sun-Times. Archived from the original on July 16, 2019. Ebert, ... Holden, Stephen (February 26, 1999). "FILM REVIEW; The Odds May Be Long, but You Can Bet on Love". The New York Times. Archived ... Lee, Nathan (September 15, 2006). "The Cure for a Cold Heart". The New York Times. Archived from the original on September 29, ... A. O. Scott (March 21, 2003). "FILM IN REVIEW; 'Gaudi Afternoon'". The New York Times. Archived from the original on January 4 ...
https://en.wikipedia.org/wiki/List_of_Juliette_Lewis_performances
Bleeding Fingers MusicBleeding Fingers Music
... there were 11 full-time composers on the Bleeding Fingers staff, many of whom had apprenticed with Zimmer. Bleeding Fingers ... In 2020, Bleeding Fingers wrote the music package for the Jeopardy! The Greatest of All Time special which aired in January of ... Bleeding Fingers also did the music package for the Jeopardy! National College Championship in 2022. Bleeding Fingers is based ... "Bleeding Fingers Music (@bleedingfingersmusic) • Instagram photos and videos". Grieving, Tim (24 August 2016). "Bleeding ...
https://en.wikipedia.org/wiki/Bleeding_Fingers_Music
Sex Is Not the EnemySex Is Not the Enemy
Time Out London. Williams, Leander (2005-04-11). Album Reviews: Garbage; Bleed Like Me. Time Out New York. Sex Is Not the Enemy ... The song was used to promote the band's final Bleed Like Me tourdates as well as the retail date for Bleed Like Me: Australian ... Warner Music had originally scheduled "Bleed Like Me" as the worldwide second single from Bleed Like Me, however after the ... LLewellyn, Sian (2005-04-01). Letting It Bleed. Classic Rock. Arnold, Chuck (2005-04-08). Music Reviews: Garbage - Bleed Like ...
https://en.wikipedia.org/wiki/Sex_Is_Not_the_Enemy
Gastrointestinal bleedingGastrointestinal bleeding
Small amounts of bleeding over a long time may cause iron-deficiency anemia resulting in feeling tired or heart-related chest ... An upper GI bleed is more common than lower GI bleed. An upper GI bleed occurs in 50 to 150 per 100,000 adults per year. A ... Gastrointestinal bleeding (GI bleed), also called gastrointestinal hemorrhage (GIB), is all forms of bleeding in the ... Bleeding is typically divided into two main types: upper gastrointestinal bleeding and lower gastrointestinal bleeding. Causes ...
https://en.wikipedia.org/wiki/Gastrointestinal_bleeding
James Robertson JusticeJames Robertson Justice
p. 1. Hogg, James; Sellers, Robert; Watson, Howard (3 March 2008). James Robertson Justice: What's the Bleeding Time?: A ... A biography entitled James Robertson Justice-What's The Bleeding Time? (referring to a joke in the first Doctor film) was ... playing his best known character of Sir Lancelot Spratt for the final time in Doctor in Trouble (1970), featured only briefly ...
https://en.wikipedia.org/wiki/James_Robertson_Justice
Viral hemorrhagic feverViral hemorrhagic fever
The bleeding time tends to be prolonged. With the exception of yellow fever vaccine and Ebola vaccines, vaccines for VHF- ... All types of VHF are characterized by fever and bleeding disorders and all can progress to high fever, shock and death in many ... Signs and symptoms of VHFs include (by definition) fever and bleeding: Flushing of the face and chest, small red or purple ... DIC is thought to cause bleeding in Rift Valley, Marburg, and Ebola fevers. For filoviral hemorrhagic fevers, there are four ...
https://en.wikipedia.org/wiki/Viral_hemorrhagic_fever
Grigori RasputinGrigori Rasputin
The bleeding would stop in no time.... How could the empress not trust Rasputin after that?" Historian Robert K. Massie has ... Rasputin was seriously wounded, and for a time it was not clear if he would survive. After surgery and some time in a hospital ... Hasic, Albinko (29 December 2016). "5 Myths and Truths about Rasputin". Time.com. Time-Life. Retrieved 15 November 2020. Massie ... Alexei's bleeding stopped the following day. Dr. S. P. Fedorov, one of the physicians who attended Alexei, admitted that "the ...
https://en.wikipedia.org/wiki/Grigori_Rasputin
Clotting timeClotting time
Dg, Dayyal (2016). "Bleeding Time (BT) and Clotting Time (CT)". BioScience. ISSN 2521-5760. Retrieved 2017-10-26. Silvestri, ... Clotting time (also called Prothrombin time) is the time required for a sample of blood to coagulate in vitro under standard ... The normal range of clotting times is 2-8 minutes. For the measurement of clotting time by the test tube method, blood is ... Prothrombin time (PT) is used for warfarin studies and the normal values differ for men and women. Adult male PT normal range ...
https://en.wikipedia.org/wiki/Clotting_time
Sean BushSean Bush
"Say no to uncontrollable bleeding". Los Angeles Times. 18 May 2004. "Research Training Award". Wilderness Medical Society. " ... Raney, Rebecca Fairley (2006-06-29). "Southern Californians See a Rise in Venomous Snakes". The New York Times. ISSN 0362-4331 ...
https://en.wikipedia.org/wiki/Sean_Bush
ThiruvallaThiruvalla
"KSRTC's parasitism bleeding KTDFC". The Times of India. Retrieved 22 January 2021. "Census of India: Search Details". Archived ... The best time to visit this historical town is after the rains as the healthy showers of monsoon leave this place lush green ... At the time of intermigration to south India, it became one of the 64 Brahmin settlements. They[who?] correlated the name to " ... Thiruvalla held a very eminent position among the spiritual and educational centres in ancient times. The Sri Vallabha Temple ...
https://en.wikipedia.org/wiki/Thiruvalla
KSRTC Terminal Complex ThiruvallaKSRTC Terminal Complex Thiruvalla
Saikiran, KP (January 22, 2021). "KSRTC's parasitism bleeding KTDFC". The Times of India. Retrieved 2022-11-06. "Thiruvalla ...
https://en.wikipedia.org/wiki/KSRTC_Terminal_Complex_Thiruvalla
Controlled BleedingControlled Bleeding
The Drowning would be the last time in Controlled Bleeding's catalog that Moriarty would be listed as a band member on a ... Official Controlled Bleeding Website Official Controlled Bleeding Facebook Page Controlled Bleeding discography at discogs.com ... In addition to the five releases mentioned above, Controlled Bleeding found the time to release even more music during this ... Slightly surprisingly, this release was credited to "The Controlled Bleeding", and was the first time that "The" appeared ...
https://en.wikipedia.org/wiki/Controlled_Bleeding
Reactions to the 2014 Peshawar school massacreReactions to the 2014 Peshawar school massacre
"Heart is bleeding: Ziauddin Yousafzai". Florida News Time. Archived from the original on 19 December 2014. Retrieved 16 ... My Hearts bleed.. " Alia Bhatt wrote "No such thing as humanity. Its appalling to even think that we are capable of being so ... At this time of national tragedy, the Government and the people of Maldives join me in extending heartfelt condolences to the ... This time yesterday our angels were alive, well and happy. Doing a show on them 2day. This will be hard#PeshawarAttack. " ...
https://en.wikipedia.org/wiki/Reactions_to_the_2014_Peshawar_school_massacre
2014 Peshawar school massacre2014 Peshawar school massacre
"Heart is bleeding: Ziauddin Yousafzai". Florida News Time. Archived from the original on 19 December 2014. Retrieved 16 ... Many times, the judges and witnesses are too scared to come forward and award due sentences to the terrorists. And even when ... During the same time, around 21 TTP terrorists were reportedly killed by PAF strikes in Khyber Agency as they attempted to ... TNN (17 December 2014). "Beslan 2004: The other cowardly terror attack on kids". Times of India. Archived from the original on ...
https://en.wikipedia.org/wiki/2014_Peshawar_school_massacre
Impossible FoodsImpossible Foods
"Bleeding veggie burgers hit restaurants for first time". The Memo. 2016-07-27. Archived from the original on 2016-08-17. ... Pierson, David (17 May 2017). "Umami says its new veggie burger tastes like meat - and bleeds like meat". Los Angeles Times. ... "We Tried a Michelin Star Version of Silicon Valley's Plant Burger That Bleeds Like Beef". The New York Observer. 1 February ... The Impossible Burger became available in grocery stores for the first time in October 2019, at Gelson's stores, which are only ...
https://en.wikipedia.org/wiki/Impossible_Foods
Premenstrual syndromePremenstrual syndrome
Symptoms resolve around the time menstrual bleeding begins. Different women experience different symptoms. Premenstrual ... An individual's pattern of symptoms may change over time. Symptoms do not occur during pregnancy or following menopause. ... This will help to establish if the symptoms are, indeed, limited to the premenstrual time, predictably recurring, and ... and even somewhat from cycle to cycle and over time. Most people with premenstrual syndrome experience only a few of the ...
https://en.wikipedia.org/wiki/Premenstrual_syndrome
Jesse VenturaJesse Ventura
In his 1999 autobiography I Ain't Got Time to Bleed, Ventura suggested that he did not plan to run for president of the United ... The religious right wants to tell people how to live." In his 1999 bestselling memoir I Ain't Got Time to Bleed, Ventura ... Jesse Ventura, "I Ain't Got Time To Bleed pg. 108 Jake Tapper, "Body Slam: The Jesse Ventura Story," pp. 104-105 "Wrestling ... At the same time, he began weightlifting and wrestling. He was a bodyguard for The Rolling Stones for a time before he entered ...
https://en.wikipedia.org/wiki/Jesse_Ventura
Mister EMister E
Death sent Tim back to his own time, but did not help Mister E, so he had to go back in time one step at a time. Mister E was ... In The New 52, E has cast an unknown spell that caused his eyes to bleed out. He appears as an enemy of Constantine. ... The Brigade won the fight and Pyotr told them they could avert the tragedy he caused if they took him back in time to the 17th ... On his walk back from the end of time E encountered Pyotr Konstantin, who tagged along with him back to the present day. Mister ...
https://en.wikipedia.org/wiki/Mister_E
New X-Men (2004 series)New X-Men (2004 series)
As time progressed, several members were added and/or earned the right to be on the team, such as Anole, Armor, Gentle, Pixie ... Bleeding Cool News. Retrieved September 7, 2019. Young X-Men #5 (October 2008) Young X-Men #6 (Released September 2008, ... Wither (Kevin Ford) - Ford is a member of the New Mutants for a short time before switching to the Hellions. The Hellions ... Icarus (Joshua "Jay" Guthrie) - Guthrie is a member of the Hellions for a short time before switching to the New Mutants. ...
https://en.wikipedia.org/wiki/New_X-Men_(2004_series)
The Third MiracleThe Third Miracle
The New York Times. Baseline & All Movie Guide. Archived from the original on October 19, 2010. Retrieved May 25, 2010. "The ... claims of miracles for the Vatican performed by a devout woman whose death caused a statue of the Virgin Mary to bleed upon and ...
https://en.wikipedia.org/wiki/The_Third_Miracle
Drones (Muse album)Drones (Muse album)
The album replaced How Big, How Blue, How Beautiful by Florence and the Machine in the previous week, the first time two ... suppression of The Truth and the urgent need to fight the hand that bleeds us still resonate in 2015, but obliquely ... Muse's ... After having self-produced their previous two albums, Muse worked with producer Robert John "Mutt" Lange to spend less time ... Roberts, Randall (9 June 2015). "Concept album by Muse just drones on". Los Angeles Times. Archived from the original on 10 ...
https://en.wikipedia.org/wiki/Drones_(Muse_album)
Cervical cancerCervical cancer
Vaginal bleeding, contact bleeding (one most common form being bleeding after sexual intercourse), or (rarely) a vaginal mass ... Among HPV-infected women, those who have had seven or more full-term pregnancies have around four times the risk of cancer ... Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sexual intercourse. While bleeding after sex ... heavy vaginal bleeding, bone fractures, and (rarely) leakage of urine or feces from the vagina. Bleeding after douching or ...
https://en.wikipedia.org/wiki/Cervical_cancer
Atari VCS (2021 console)Atari VCS (2021 console)
"Company News; Hasbro Completes Sale Of Interactive Business - New York Times". New York Times. January 30, 2001. Archived from ... "Rob Wyatt Officially Joins the Atari VCS Team". Bleeding Cool. Archived from the original on June 28, 2018. Retrieved June 27, ... According to Atari CEO Fred Chesnais, this period gave them time to review what they wanted the Ataribox to do, and revise the ... In December 2017, just prior to opening for pre-orders for the VCS (at the time known as Ataribox), Atari recognized there were ...
https://en.wikipedia.org/wiki/Atari_VCS_(2021_console)
La DéfenseLa Défense
The biggest shopping centre in Europe (at the time), the Quatre Temps, was created in 1981. In 1982, the EPAD launched the Tête ... In December 2005, Bernard Bled, CEO & Chairman of EPAD (La Defense Management & Development Office) announced an ambitious 9- ...
https://en.wikipedia.org/wiki/La_Défense
Newell W. SpicerNewell W. Spicer
By the time of the May 1864 Yazoo City Expedition, Spicer was a Lieutenant Colonel and in command of the regiment, which had ... He was also a leader of pro-abolitionist forces during Bleeding Kansas, a violent period in the history of Kansas when factions ... In Kansas, he joined the town militia and was part of raids against pro-slavery factions during Bleeding Kansas. Spicer arrived ...
https://en.wikipedia.org/wiki/Newell_W._Spicer
April 1918April 1918
Women on the Faroe Islands voted for the first time in elections, with the New Self-Government winning a majority in the island ... discovered tranexamic acid which is now used to treat postpartum bleeding, in Tokyo (d. 2016); Robert Thieme, American ... Women in Denmark were allowed to vote for the first time in elections. The Venstre Party won a majority in the Folketing ( ... "The Armenian people from ancient to modern times", pp. 292-293 "History of the Soviet Navy". Archived from the original on 3 ...
https://en.wikipedia.org/wiki/April_1918
Nonviolent video gameNonviolent video game
The Times. 29 May 2003. Gamespot Game of the Year 2012. 25 December 2012. IGN Game of the Year 2012. Game of the Year, 16th ... Instead of the player's face bleeding, the Chex piece becomes progressively more covered in slime. Descent - A game lacking ... At times, individual games considered too violent have been censored or banned in such countries as Australia, Greece, etc. In ... At the same time, Judge James Moore had taken the motion to revoke Thompson's license under advisement. Jack Thompson appeared ...
https://en.wikipedia.org/wiki/Nonviolent_video_game
Gloriosa superbaGloriosa superba
It is also a crop that is slow to propagate; each split tuber produces only one extra plant in a year's time. In vitro ... Longer-term effects include peeling of the skin and prolonged vaginal bleeding in women. Colchicine is known to cause alopecia ... 2011). Gloriosa superba - an endangered plant spotted for the first time from forest of Tpchanchi, Hazaribag (Jharkhand) India ...
https://en.wikipedia.org/wiki/Gloriosa_superba
Fabchannel.comFabchannel.com
With a bleeding heart we're pulling the plug of our online archive Friday 13th of March. Until that time, enjoy your favorite ...
https://en.wikipedia.org/wiki/Fabchannel.com
The Final Solution (American band)The Final Solution (American band)
Another song, "Bleeding Rose", is featured on a flexi-disc along with the first issue of the San Francisco fanzine Cream Puff ... most of whom spent time at University of San Francisco. Regarding the group's potentially offensive moniker, the Final Solution ... Bleeding Rose'". Unterberger, Richie. "The Final Solution - Biography". allmusic.com. Retrieved June 21, 2016. "Live at the ...
https://en.wikipedia.org/wiki/The_Final_Solution_(American_band)
Axel von Fersen the YoungerAxel von Fersen the Younger
Von Fersen divided his time between Paris, Versailles, and his new regiment in Valenciennes. During this time, the Diamond ... Von Fersen's face bled where a stone had cut it, his decorations glittering in the sun. The guards, who were supposed to ... During this time von Fersen was still attempting to find a way to save her and the remaining royal family. On 11 August he ... Before I had time to respond, he remarked that the Court of Sweden seemed to take a pleasure in sending agents and ambassadors ...
https://en.wikipedia.org/wiki/Axel_von_Fersen_the_Younger
Blackburn BuccaneerBlackburn Buccaneer
Times [London, England], 17 July 1962: 6 via The Times Digital Archive, 3 May 2013. Chesneau 2005, p. 9. Chesneau 2005, p. 24. ... BLC bled high pressure air directly from the engines, which was "blown" against various parts of the aircraft's wing surfaces. ... Only five aircraft remained operational by the time the Buccaneer was retired from service in 1991. Early in the Buccaneer ... five times that of the Martel AJ 168 anti-ship missile, while also being significantly more powerful. In order to dramatically ...
https://en.wikipedia.org/wiki/Blackburn_Buccaneer
Kari WahlgrenKari Wahlgren
Her first voice-over role in video games was in Buffy the Vampire Slayer: Chaos Bleeds where she played Willow Rosenberg. In ... Martel, Ned (March 18, 2005). "Movie Review - Steamboy". The New York Times. Hunter, Stephen (March 25, 2005). "'Steamboy': ... and takes some time to get used to. Wahlgren has been involved in a number of video games. ... some of which had accents or were from certain time periods. Wahlgren's debut anime role was Haruko Haruhara in a six-episode ...
https://en.wikipedia.org/wiki/Kari_Wahlgren
Desmond MilesDesmond Miles
Schiesel, Seth (12 December 2011). "Time-Travel Tip for Constantinople: Pack Daggers". The New York Times. Retrieved 24 ... Upon returning to his room, Desmond, suffering from the "Bleeding Effect" due to prolonged exposure to the Animus, discovers he ... and at some point would be able to time-travel between different time periods. North became greatly interested in the concept ... After spending more time in Animus 2.0, Desmond begins to adjust to his newly developed skills and becomes agile and expert ...
https://en.wikipedia.org/wiki/Desmond_Miles
Star Wars Jedi: Fallen OrderStar Wars Jedi: Fallen Order
The team introduced several difficulty modes, which mostly change the amount of time players have to parry an enemy, how ... Sheehan, Gavin (January 2, 2020). "The New York Game Awards Announces 2020 Nominees". Bleeding Cool. Archived from the original ... Gault, Matthew (November 22, 2019). "How Respawn Entertainment Made the Best 'Star Wars' Video Game of the Past Decade". Time. ... over time going insane and succumbing to the dark side of the Force. Cal refuses Malicos' offer to teach him this dark power ...
https://en.wikipedia.org/wiki/Star_Wars_Jedi:_Fallen_Order
Chao Tzee ChengChao Tzee Cheng
At the same time of Ong's arrest, Lee's body was found inside the abandoned taxi, and there were 15 stab wounds on his body. ... He stated that the wounds would have cause slow bleeding, which could lead to a slow, painful death. However, Chao added that ... Some time in November 1992, both Maniam and Asokan murdered Tan and drove Tan's car to Mandai, burning it together with Tan's ... At the time of his death, Chao was holding posts in the Institute of Science and Forensic Medicine, Ministry of Health, ...
https://en.wikipedia.org/wiki/Chao_Tzee_Cheng
Mass shootings in the United StatesMass shootings in the United States
... mass shooters four times more frequently premeditated their homicides, eight times more frequently killed strangers, and were ... "if it bleeds, it leads". Other posited factors contributing to the prevalence of mass shootings include perpetrators' desire to ... The New York Times records 90 mass shootings from 1966 to 2012. The United States has had more mass shootings than any other ... Tampa Bay Times. Retrieved February 20, 2018. As noted above, there is no widely accepted definition of mass shootings. People ...
https://en.wikipedia.org/wiki/Mass_shootings_in_the_United_States
Terminal ballisticsTerminal ballistics
This means that all the kinetic energy from the bullet is transferred into the target in a very short period of time. The most ... While a bullet that penetrates through-and-through tends to cause more profuse bleeding, allowing a game animal to be ... which are released by the carrier projectile at a required height or time above their target. For US artillery ammunition, ...
https://en.wikipedia.org/wiki/Terminal_ballistics
Elvira DolinarElvira Dolinar
She trained as a teacher, since teaching was, at the time, one of the only intellectual professions in Slovenia considered ... Dolinar died in 1961 in Bled. Throughout the period during which Slovenia was governed by communist Yugoslavia, beginning in ... Mihurko Poniž, Katja (2011). Wayne, Tiffany K. (ed.). Feminist Writings from Ancient Times to the Modern World: A Global ... a sentiment that contradicted the Catholic values held by most Slovenians at the time. She was widely criticised, especially by ...
https://en.wikipedia.org/wiki/Elvira_Dolinar
Doctor FateDoctor Fate
Over time, Nabu instead empowered mortal agents to act on his behalf and the Lords of Order, the first being Kent Nelson, the ... Johnston, Rich (2020-12-18). "Justice League Dark Series Cancelled, Repurposed As Back-Up Strip". Bleeding Cool News And Rumors ... This time Eric's mind did not mature. He would act as Doctor Fate alongside Linda, the two often merging in order to become ... Extant uses his time manipulation powers to rapidly age Kent and Inza to their proper physical ages. Extant also scatters the ...
https://en.wikipedia.org/wiki/Doctor_Fate
Anatoly MarchenkoAnatoly Marchenko
The New York Times. 12 December 1986. "The press: samizdat West". Time. Vol. 105, no. 15. 14 April 1975. Alexeyeva, Lyudmila; ... They also helped him receive medical care, both for his ears, and for problems with internal bleeding in his stomach. The Gulag ... During this time he had met several fellow dissidents, including Larisa Bogoraz, the wife of his associate Yuli Daniel, who ... During his time in the camps Marchenko educated himself, reading a number of accessible socio-political works, including the ...
https://en.wikipedia.org/wiki/Anatoly_Marchenko
Pierre Charles Alexandre LouisPierre Charles Alexandre Louis
After determining the timing of onset, duration and frequency of death rates of the disease, Louis then analyzed the timing of ... Louis found that those who were bled early recovered earlier than those bled late, but also died at greater rates. Based on his ... Little is known of Louis' training in math or medicine, or how he developed his "numerical method". At the time of his practice ... Louis' approach was strongly resisted by doctors at the time, who were unwilling to wait for tests to determine if current ...
https://en.wikipedia.org/wiki/Pierre_Charles_Alexandre_Louis
Annie CampbellAnnie Campbell
Annie complains of being in pain and bleeding one day and assumes she is dying, but Irene Roberts (Lynne McGranger) discovers ... Annie returns several months later and resumes things with Romeo when they spend time together working on a reversed gender ... at times but school tamed her. She gradually transforms into a young woman and takes an interest in males. She is also "very ... though there would be fun times ahead for them. In April 2010, Mitchell revealed that Romeo and Annie would go on their first ...
https://en.wikipedia.org/wiki/Annie_Campbell
Lesley BlanchLesley Blanch
The New York Times "Cy Twombly". www.vlinder-01.dds.nl. NYRB Retrieved 15 July 2018. Isabella Burton, Tara (8 January 2016). " ... Under a Lilac-Bleeding Star, Travels and Travellers 1965: The Nine Tiger Man, a Tale of Low Behaviour in High Places, London: ... Official website ILA, translation rights Time Traveller, Guardian Online Review Profile article by Joe Boyd, 9 July 2005 Lesley ...
https://en.wikipedia.org/wiki/Lesley_Blanch
SusperiaSusperia
... suffering from acute stomach pain and heavy bleeding. He was expected to remain hospitalised for some time. It was later ... he started to concentrate fully on Susperia together with old-time friend Cyrus. At Wacken Open Air Festival in 1999, Tjodalv ...
https://en.wikipedia.org/wiki/Susperia
Astrid & Lilly Save the WorldAstrid & Lilly Save the World
Time described the series as "Buffy minus the male gaze." Angie Han of The Hollywood Reporter wrote that Astrid & Lilly has a " ... Bleeding Cool called Astrid & Lilly "a unique and heartfelt story" and praised the show for its "engaging and often hilarious ... Astrid spends all her time with Lilly imagining themselves as "Olivia Benson types" while they spy on their classmates and ... Bender, Brittney (2022-01-27). "Astrid & Lilly Season 1 Episode 1 Review: Monster-Hunting Duo We Love". Bleeding Cool News And ...
https://en.wikipedia.org/wiki/Astrid_&_Lilly_Save_the_World
Haste the DayHaste the Day
Bleeding Through, Between the Buried and Me, and Every Time I Die), and behind the scenes antics (such as prank OnStar calls). ... Chaulk explained in an interview that his decision weighed on him to leave to focus on his new marriage at the time and to ... Haste the Day finished off 2007 with a full national tour with As I Lay Dying before taking some time off for Christmas. In ... Although no specific announcement was made, touring lead guitar player Dave Krysl (ex-New Day Awakening) became a full-time ...
https://en.wikipedia.org/wiki/Haste_the_Day
Bleeding time: MedlinePlus Medical EncyclopediaBleeding time: MedlinePlus Medical Encyclopedia
Bleeding time is a medical test that measures how fast small blood vessels in the skin stop bleeding. ... Bleeding time is a medical test that measures how fast small blood vessels in the skin stop bleeding. ... Bleeding time, ivy - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. Philadelphia ... Blotting paper is touched to the cuts every 30 seconds until the bleeding stops. The provider records the time it takes for the ...
https://medlineplus.gov/ency/article/003656.htm
Bleeding Time: Reference Range, Interpretation, Collection and PanelsBleeding Time: Reference Range, Interpretation, Collection and Panels
The test involves making a puncture wound in a superficial area of the skin and monitoring the time needed for bleeding to stop ... Bleeding time is a laboratory test to assess platelet function and the bodys ability to form a clot. ... the bleeding time is the main indicator of this function; thus, measuring bleeding time in patients with bleeding disorders is ... The bleeding time is defined as the time from the incision until all bleeding has stopped. ...
https://emedicine.medscape.com/article/2085022-overview
Bleeding TimeBleeding Time
... , Bleeding Times, Time, Bleeding, Times, Bleeding, bleeding time (lab test), bleeding time, bleeding tests time, ... bleeding times, time bleeding, bleeding test time, bleeding time procedure, bleed time, bleeding time test, BLEEDING TIME TEST ... Bleeding time, Bleeding time (procedure), Bleeding time - observation, Bleeding time procedure, Bleeding time, NOS, Bleeding ... Test;bleeding time, time bleed, bleeding testing time, ... Bleeding Time. Aka: Bleeding Time *Normal. *Range: 2 to 9.5 ...
https://fpnotebook.com/legacy/HemeOnc/Lab/BldngTm.htm
Browsing by Subject Bleeding TimeBrowsing by Subject "Bleeding Time"
Bleeding and coagulation studies in smallpox and chicken-pox, Madras, India, 1962-63  ...
https://extranet.who.int/iris/restricted/browse?authority=Bleeding+Time&type=mesh
Auditor slams defence deal thats bleeding India | Latest News Delhi - Hindustan TimesAuditor slams defence deal that's bleeding India | Latest News Delhi - Hindustan Times
Join Hindustan Times. Create free account and unlock exciting features like. Newsletters, Alerts and Recommendations Bookmark ... The ship is four years past the estimated time of arrival, now expected in 2012. ...
https://www.hindustantimes.com/delhi/auditor-slams-defence-deal-that-s-bleeding-india/story-wd0ylqMRbPUTnBpEFJEdTI.html
New Study Provides Information About Bleeding Events and Timing of Diagnosis Among Children Younger Than Two with von...New Study Provides Information About Bleeding Events and Timing of Diagnosis Among Children Younger Than Two with von...
Bleeding Events and Timing of Diagnosis Among Children Younger Than Two with VWD ... New Study Provides Information About Bleeding Events and Timing of Diagnosis Among Children Younger Than Two with von ... Information about bleeding events among children with VWD-like the severity of the bleed and if and when they require treatment ... Bleeds occurred most often in the mouth or nose, in the head, after circumcision (for boys), and with general cuts on the body. ...
https://www.cdc.gov/ncbddd/vwd/features/bleeding-events-children-vwd.html
bleeding Archives - Houston Forward Timesbleeding Archives - Houston Forward Times
FORWARD TIMES - JOIN OUR EMAIL LIST. Get News Updates Delivered Directly To Your Inbox!. ... The Black Community is Bleeding to Death. by Chelsea Lenora White May 18, 2016. ...
https://forwardtimes.com/tag/bleeding/
Favorite all time Eagles bracket: Elite 8 - Bleeding Green Nation
Bleeding Green Nation a Philadelphia Eagles community Follow Bleeding Green Nation online:. * ... You can opt out at any time. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. ... Sign up for the newsletter Sign up for the Bleeding Green Nation Daily Roundup newsletter! A daily roundup of all your ... Share All sharing options for: Favorite all time Eagles bracket: Elite 8 ...
https://www.bleedinggreennation.com/2020/4/2/21204242/favorite-all-time-eagles-bracket-elite-8-top-best-greatest-ever-philadelphia-nfl-rank-great-dawkins
The Bleeding Edge Explores How Devices Can Damage the Body | New Times Broward-Palm BeachThe Bleeding Edge Explores How Devices Can Damage the Body | New Times Broward-Palm Beach
KEEP NEW TIMES BROWARD-PALM BEACH FREE... Since we started New Times Broward-Palm Beach, it has been defined as the free, ... Heres hoping The Bleeding Edge gets the right attention on a decidedly unsexy topic.. The Bleeding Edge premieres on Netflix ... Netflixs The Bleeding Edge Exposes the Horrors the FDA Approves From Medical Device Makers April Wolfe July 25, 2018 8:00AM ... In Netflixs documentary The Bleeding Edge, Ana Fuentes is one of the women whose story is told following her experience with ...
https://www.browardpalmbeach.com/film/the-bleeding-edge-explores-how-devices-can-damage-the-body-9701603
It's Not Panic Time, But... - Bleed Cubbie Blue
Bleed Cubbie Blue a Chicago Cubs community Follow Bleed Cubbie Blue online:. * ... More From Bleed Cubbie Blue * Cubs sign right-hander Jameson Taillon * Tom Ricketts gave the green light and the Cubs made two ... Its remarkable to note that hes on target to have 500+ AB and play in more than 140 games for the first time in seven years. ... So what? If the idea is to win now, why not go get a starting pitcher who is a two-time 18-game winner with World Series ...
https://www.bleedcubbieblue.com/2007/7/28/61634/0611
R|T: The Retail Times - Life House looks to stop hotel bleeding | BetaKitR|T: The Retail Times - Life House looks to stop hotel bleeding | BetaKit
The Retail Times is a weekly newsletter covering retail tech news from Canada and around the globe. ... 0 replies on "R,T: The Retail Times - Life House looks to stop hotel bleeding" ... R,T: The Retail Times - Life House looks to stop hotel bleeding ... The Retail Times is a weekly newsletter covering retail tech ...
https://betakit.com/rt-the-retail-times-life-house-looks-to-stop-hotel-bleeding/
The First & Last Time I Will Encourage You To Watch A Clip From "Mike & Mike"… - Can't Stop The Bleeding
The First & Last Time I Will Encourage You To Watch A Clip From "Mike & Mike"…. Published on 2/26/2009. 2/26/2009. by GC ... The First & Last Time I Will Encourage You To Watch A Clip From "Mike & Mike"…. ... Save my name, email, and website in this browser for the next time I comment. ...
https://cantstopthebleeding.com/the-first-last-time-i-will-encourage-you-to-watch-a-clip-from-mike-mike
Cat health - Ask members * If your pet is vomiting-bleeding-diarrhea etc. Vet time! - Pet forum for dogs cats and humans - Pets...Cat health - Ask members * If your pet is vomiting-bleeding-diarrhea etc. Vet time! - Pet forum for dogs cats and humans - Pets...
Threads in Forum : Cat health - Ask members * If your pet is vomiting-bleeding-diarrhea etc. Vet time!. Forum Tools Search this ... Sub-Forums : Cat health - Ask members * If your pet is vomiting-bleeding-diarrhea etc. Vet time!. Search this Forum ... Cat health - Ask members * If your pet is vomiting-bleeding-diarrhea etc. Vet time! ... All times are GMT -5. The time now is 11:14 PM. ...
http://pets.ca/forum/forumdisplay.php?f=75&daysprune=-1&order=asc&sort=postusername
Killing Time | Bleed | 20 Buck SpinKilling Time | Bleed | 20 Buck Spin
Killing Time In advance of the bands upcoming Fall tour with Narrow Head, Dallas, Texas based Bleed release the new track ... Killing Time will be on the as yet unnamed new album in re-recorded form, making this advanced single version unique in and of ... Killing Time, their first new music made public since the release of the Somebodys Closer EP. The new track is a first ... esteban miguel graneros Oi! New bleed song just in time for that Detroit show W/ narrow head in a week or so! Ill be singing ...
https://listen.20buckspin.com/album/killing-time
Fall 2021 Bleeding Times - NYC Hemophilia ChapterFall 2021 Bleeding Times - NYC Hemophilia Chapter
In Bleeding Times. Fall 2021 Bleeding Times2021-10-052021-12-01https://www.nyhemophilia.org/wp-content/uploads/2016/07/NYCHC_ ... Fall 2021 Bleeding Times. By Brandon Greene Posted October 5, 2021 ...
https://www.nyhemophilia.org/fall-2021-bleeding-times/
When the nation bleeds, Harlem hemorrhages | Manhattan Times | Washington Heights, Inwood & Harlem Online | The Uptown..."When the nation bleeds, Harlem hemorrhages" | Manhattan Times | Washington Heights, Inwood & Harlem Online | The Uptown...
"When the nation bleeds, Harlem hemorrhages" , Manhattan Times. Posted on July 17, 2020 ... "When the nation bleedsAfrican-AmericanBlackCoronavirusCoronavirus PandemicCOVID-19DominicansHarlemHarlem hemorrhages"Harlem USA ... "When the nation bleeds, Harlem hemorrhages" , Manhattan Times. We invite you to subscribe to the weekly Uptown Love newsletter ... Hyper-localInwoodLatinosLatinxLION publishersManhattan TimesNorthern ManhattanPandemicuptownUptown CollectiveUptown Manhattan ...
https://www.uptowncollective.com/2020/07/17/when-the-nation-bleeds-harlem-hemorrhages-manhattan-times/
DRC - Digital Room Correction - Time Alignment? Is this a bleeding edge technology solution looking for a problem (and profit...DRC - Digital Room Correction - Time Alignment? Is this a bleeding edge technology solution looking for a problem (and profit...
DRC - Digital Room Correction - Time Alignment? Is this a bleeding edge technology solution looking for a problem (and profit ... Assuming that time alignment is critical, and important to the end result, it begs the question, which time alignment is really ... Assuming that time alignment is critical, and important to the end result, it begs the question, which time alignment is really ... Assuming that time alignment is critical, and important to the end result, it begs the question, which time alignment is really ...
https://www.audiosciencereview.com/forum/index.php?threads/drc-digital-room-correction-time-alignment-is-this-a-bleeding-edge-technology-solution-looking-for-a-problem-and-profit-for-its-evangelists.36076/#post-1264894
Upper Gastrointestinal Bleeding (UGIB): Practice Essentials, Background, EtiologyUpper Gastrointestinal Bleeding (UGIB): Practice Essentials, Background, Etiology
Upper gastrointestinal bleeding (UGIB) is defined as bleeding derived from a source proximal to the ligament of Treitz. ... Acute gastrointestinal bleeding is a potentially life-threatening abdominal emergency that remains a common cause of ... 6] Bleeding from the upper GI tract is approximately 4 times more common than bleeding from the lower GI tract and is a major ... Time to endoscopy and outcomes in upper gastrointestinal bleeding. Can J Gastroenterol. 2009 Jul. 23(7):489-93. [QxMD MEDLINE ...
https://www.medscape.com/answers/187857-193361/when-is-ct-scanning-and-ultrasonography-indicated-for-the-workup-of-upper-gastrointestinal-bleeding-ugib
bleeding time - eLearning Platformbleeding time - eLearning Platform
Old keyword: bleeding time. Diagnosis of VWD: Strategies for the Developing World. In the Sunday afternoon joint Laboratory ...
https://elearning.wfh.org/old-keyword/bleeding-time/
The effect of Tranexamic Acid on operation time, bleeding and complications in lumbar spine surgery, a double blind RCT</em>...The effect of Tranexamic Acid on operation time, bleeding and complications in lumbar spine surgery, a double blind RCT</em>...
Forbech Elmose, S, Andersen, MØ, Andresen, EB & Carreon, LY 2017, The effect of Tranexamic Acid on operation time, bleeding ... The effect of Tranexamic Acid on operation time, bleeding and complications in lumbar spine surgery, a double blind RCT. / ... The effect of Tranexamic Acid on operation time, bleeding and complications in lumbar spine surgery, a double blind RCT. 2017. ... The effect of Tranexamic Acid on operation time, bleeding and complications in lumbar spine surgery, a double blind RCT. ...
https://portal.findresearcher.sdu.dk/da/publications/the-effect-of-tranexamic-acid-on-operation-time-bleeding-and-comp
Ragnarock Open Air 2014: Haben Bleeding Red bestätigt - Time For Metal - Das Metal Magazin & Metal PodcastRagnarock Open Air 2014: Haben Bleeding Red bestätigt - Time For Metal - Das Metal Magazin & Metal Podcast
Time For Metal e.V.. Postfach 30 01 39. 41352 Korschenbroich. Sitz: Willich Kontakt , Contact: Hier,Here. Werben: Hier,Here ... BLEEDING RED haben einen eigenen Sound, der von dämonischer Atmosphäre ebenso lebt, wie von brachialen Riffs, melodischen Lead- ... BLEEDING RED gelingt es vielfältige Einflüsse zu einer eisenharten blackened-Death-Legierung zu verschmelzen. ... Management Power Metal Progressive Metal Progressive Rock Review Rock Schweden Thrash Metal Time For Metal Tour USA ...
https://time-for-metal.eu/ragnarock-open-air-2014-haben-bleeding-red-bestaetigt/
bleeding monochrome zombie - killing time with a camera …bleeding monochrome zombie - killing time with a camera …
One Reply to "bleeding monochrome zombie" * Pingback: 90s rocker zombie « Killing time with a camera… ...
https://steviegill.wordpress.com/2010/12/23/bleeding-monochrome-zombie/
Determination of Bleeding Time HAP Lab Manual, Journal PDFDetermination of Bleeding Time HAP Lab Manual, Journal PDF
Determination of Bleeding Time. Human Anatomy and Physiology Practical, Principle, Procedure, Journal, Lab manual, PDF, ... Normal clotting time and bleeding time values differ because bleeding time is the time for stopping bleeding by the formation ... Determination of Bleeding Time. BP107P Human Anatomy and Physiology Practical. Aim. To determine the bleeding time of a patient ... Determination of Bleeding Time. Table of contents. *Determination of Bleeding Time*Aim ...
https://pharmacyinfoline.com/determination-of-bleeding-time/
Strength Cartel Time to Bleed Blue PunchStrength Cartel Time to Bleed Blue Punch
TIME 2 BLEED is a non-stim formula that elevates nitric oxide levels to the NEXT LEVEL while increasing your lactic acid ... BLUE PUNCH TIME 2 BLEED. This PUMP product is made for the homies that are willing to GET THIS MONEY, and put in that BLOOD and ... TIME 2 BLEED. This PUMP product is made for the homies that are willing to GET THIS MONEY, and put in that BLOOD and SWEAT in ... BE CAREFUL, because TIME 2 BLEED will make you the MOST HATED in the gym with that CRAZY PUMP, especially when STACKED with ...
https://strengthcartel.com/products/strength-cartel-time-to-bleed-blue-punch
Tranexamic Acid for Upper Gastrointestinal Bleeding - Full Text View - ClinicalTrials.govTranexamic Acid for Upper Gastrointestinal Bleeding - Full Text View - ClinicalTrials.gov
rate of recurrent bleeding [ Time Frame: Within one-month of emergency department visit ]. *death of any cause [ Time Frame: ... Endoscopic signs of bleeding [ Time Frame: Within 24 hours of emergency department visit ]. *Length of stay [ Time Frame: ... Endoscopic procedure time/difficulty [ Time Frame: Within 24 hours of emergency department visit ]. *Need for transfusion [ ... Time Frame: Within one-month of emergency department visit ]. *Need for surgery/angiographic intervention [ Time Frame: Within ...
https://clinicaltrials.gov/ct2/show/NCT01713101?term=taugib&rank=1
Upper Gastrointestinal Bleeding (UGIB) Guidelines: Perforated and Bleeding Peptic Ulcer Clinical Practice Guidelines (2020),...Upper Gastrointestinal Bleeding (UGIB) Guidelines: Perforated and Bleeding Peptic Ulcer Clinical Practice Guidelines (2020),...
Upper gastrointestinal bleeding (UGIB) is defined as bleeding derived from a source proximal to the ligament of Treitz. ... Acute gastrointestinal bleeding is a potentially life-threatening abdominal emergency that remains a common cause of ... Time to endoscopy and outcomes in upper gastrointestinal bleeding. Can J Gastroenterol. 2009 Jul. 23(7):489-93. [QxMD MEDLINE ... Sadic J, Borgstrom A, Manjer J, Toth E, Lindell G. Bleeding peptic ulcer - time trends in incidence, treatment and mortality in ...
https://emedicine.medscape.com/article/187857-guidelines
How Many Days Should You Bleed During Your Period?How Many Days Should You Bleed During Your Period?
Learn about the duration of bleeding during a typical menstrual cycle and when you should contact your healthcare provider. ... Wearing more than one pad at a time to absorb bleeding. *Having to change pads or tampons overnight (a time when bleeding often ... Still, its not normal to bleed for more than seven days every month or not bleed at all once you have passed menarche. This is ... Heavy bleeding is a sign to contact your healthcare provider. (One such cycle is OK, but two or three are not.) So what does ...
https://www.verywellhealth.com/how-long-does-a-period-last-how-many-days-each-month-2721931
One Womans Story of Treating Heavy Bleeding and Fibroids - The Weston A. Price FoundationOne Woman's Story of Treating Heavy Bleeding and Fibroids - The Weston A. Price Foundation
Almost 5 months bleeding now, I hate this. The longest time that I stop the heavy bleeding is like 1 week but I kept spotting. ... However, this time around the bleeding never stopped. After 2 months of heavy bleeding I could barely walk 2 feet without ... At this point it was January and I had been bleeding for 3 months. After a few weeks my bleeding stopped. During this time my ... 2- Lo-Ovral: three times daily until bleeding stops, then two times daily per two days and then daily. 3. Dilation and ...
https://www.westonaprice.org/health-topics/womens-health/one-womans-story-of-treating-heavy-bleeding-and-fibroids/
5 Ways to Honor Your Moon Time Bleed
Moon Time can be viewed as a mini ego death every time we bleed. Can you think of some times where you were eager and ready to ... It is a time for a renewal and cleansing of the body through physical removal of the uterine lining. At this time, bacteria and ... bleed and start a new cycle after experiencing heavy energy? Bringing the idea that each cycle ha ... Moon Time can be viewed as a mini ego death every time we bleed. Can you think of some times where you were eager and ready to ...
https://www.moonriseritual.com/post/5-ways-to-honor-your-moon-time-bleed
Where Women Have No Doctor - A Health Guide for Women (Hesperian Foundation, 1997, 600 p.): Chapter 22: Abnormal Bleeding from...Where Women Have No Doctor - A Health Guide for Women (Hesperian Foundation, 1997, 600 p.): Chapter 22: Abnormal Bleeding from...
Problems with Monthly Bleeding. Heavy monthly bleeding, or bleeding that lasts a long time. ... Monthly bleeding that comes too often, or bleeding at other times. When monthly bleedings come too far apart, or have stopped. ...
http://www.nzdl.org/cgi-bin/library?e=d-00000-00---off-0cdl--00-0----0-10-0---0---0direct-10---4-------0-0l--11-en-50---20-about---00-0-1-00-0-0-11----0-1-&a=d&c=cdl&cl=CL1.46&d=HASH2204efb6053d0e6ef4ae0d.27.2
Lake BledUpper GastroinSkipPostojna CaveVaginalNosebleedsRupture and bleedSymptoms2022Endoscopy2020MenstrualDisordersUGIBDiagnosisSloveniaDisorderCoagulopathyStopsHemorrhageOccurCapillaryUterineStop The BleeCapillariesAbnormalNoseHeavilyGingivalProfuselyProthrombin timeChronicComplicationsAggregationCastleMenstruationProlongClinicallyBlood clotsAnticoagulantHeavyAcuteOccursNarrow HeadThrombosisProphylaxisNormalLastsDeathSuggestsCessationSuperficialContentExcessiveAnticoagulation
Lake Bled7
  • The most famous spot in Slovenia is Lake Bled which situated in the Julian Alps formed about 14,000 years ago. (rove.me)
  • To me it's a picture perfect of beautiful Lake Bled. (debbzie.com)
  • Lake Bled surrounds Bled island in the Julian Alps in northwestern Slovenia. (debbzie.com)
  • It's perched on top a steep cliff, 130 metres above the glacial lake Bled. (debbzie.com)
  • The only but is that perhaps the visit to Lake Bled is too tight to do all the activities. (civitatis.com)
  • This amazing fort is suspended over a giant cliff face from where you will find fantastic views across Lake Bled . (civitatis.com)
  • One of the most picturesque locations in Slovenia is Lake Bled and its iconic church on Bled Island starting with sunrise at the shore and ending with sunset from a stunning vantage point. (phototc.com)
Upper Gastroin2
  • This study is to see whether the early intravenous administration of tranexamic acid improves the outcome of acute upper gastrointestinal bleeding. (clinicaltrials.gov)
  • Previous studies reported that IV/Oral administration of tranexamic acid improves the outcome upper gastrointestinal bleeding. (clinicaltrials.gov)
Skip1
  • After a first period, some people bleed for more than the average number of days and/or skip a few periods in a row. (verywellhealth.com)
Postojna Cave1
  • Before heading to Postojna Cave for a journey to the centre of the earth , I made another stop at Bled Castle. (debbzie.com)
Vaginal5
  • After a few weeks with no change, she looked online and read that for some people it takes weeks before vaginal bleeding starts. (ijpr.org)
  • Maghrib enters at 6 pm and she sees heavy vaginal bleeding at 6:10 pm. (muslimacoaching.com)
  • After many doctors appointments and tests nothing could be found on why I was having vaginal bleeding. (earthclinic.com)
  • For Heavy Vaginal Bleeding Treatment in Vadodara, Call now at 72279 82345 Or visit Sankalp Hospital at Vasna Raod. (sankalphospital.in)
  • Schedule your appointment for Heavy vaginal bleeding Treatment in Vadodara with Dr. Shuchi Doshi, Gynecologist in Vadodara at Sankalp Hospital . (sankalphospital.in)
Nosebleeds2
  • Nose bleeds might be due to any of the other nosebleeds causes. (home-remedies-for-you.com)
  • When they don't have enough platelets (PLATE-lits), kids with leukemia may bruise easily, get nosebleeds, or bleed for a long time after even a minor cut. (kidshealth.org)
Rupture and bleed2
  • Hematomas - organized, local collections of blood that can rupture and bleed. (petplace.com)
  • The pressure of the extra blood can sometimes cause the more fragile vessels to rupture and bleed more easily. (themasterpiecemom.com)
Symptoms7
  • The symptoms are basically extremely heavy menstrual bleeding accompanied by the passing of tissue, (it looks like a large blood clot, but is actually the lining of the uterus), and sometimes heavy abdominal, back, or leg cramping. (westonaprice.org)
  • My symptoms improved somewhat, and I thought that it might just take some time to get back to normal. (westonaprice.org)
  • Apparently, every time I would get stressed-out, the symptoms would get really bad. (westonaprice.org)
  • However, if you happen to experience a nose bleed, it does not mean that you have sinusitis, unless you have the other symptoms of sinusitis too. (home-remedies-for-you.com)
  • Learn more about bleeding disorders, their symptoms, treatments, and how to prepare for emergencies on the Division of Blood Disorders website . (cdc.gov)
  • Here, we found that among the international and domestic regulatory Acot1, Acot2, Vnn1, and Nr1d1 showed a dose-response and time-dependent values, there are massive diferences within the reference doses (RfD) decided, upregulation pattern, suggesting these transcripts as potential biomarkers for ranging from 0 symptoms type 2 diabetes [url=http://healthdept.sp.gov.lk/purchase/Retrovir/]retrovir 300 mg discount with mastercard[/url]. (ehd.org)
  • Use the tools below to check for signs and symptoms of a bleeding disorder. (cdc.gov)
20221
Endoscopy1
  • Performing endoscopy as soon as possible, particularly in high-risk patients (Management decisions can be guided based on the damage noted from recent hemorrhage during endoscopy, as this can help predict further bleeding risk. (medscape.com)
20201
  • Perforated and bleeding peptic ulcer clinical practice guidelines were released in January 2020 by the World Society of Emergency Surgery (WSES). (medscape.com)
Menstrual5
  • Women with VWD can experience heavy or abnormal bleeding during menstrual periods and after childbirth. (cdc.gov)
  • Heavy menstrual bleeding , also known as menorrhagia, affects more than 10 million American women each year, or one out of every five women. (cdc.gov)
  • Heavy menstrual bleeding may be the most noticeable symptom of a bleeding disorder that can be treated. (cdc.gov)
  • Use a chart to track period cycles over a few months to help determine if there is heavy menstrual bleeding. (cdc.gov)
  • Consider helpful resources that you can complete ahead of time and bring to your appointment like a menstrual chart or healthcare diary to help you prepare for the visit. (cdc.gov)
Disorders12
  • Researchers from CDC and the U.S. Hemophilia Treatment Center Network analyzed data from a large public health monitoring program that tracked the care and health outcomes of people with bleeding disorders who received care at Hemophilia Treatment Centers (HTCs) in the United States from 2003-2011. (cdc.gov)
  • Children with VWD from families with a history of bleeding disorders were diagnosed 4 months earlier than those that did not have a family history of bleeding disorders. (cdc.gov)
  • Bleeding time is prolonged in a few disorders like vascular lesions, platelet defect, severe liver disease, uremia, and anti-coagulant drug administration. (pharmacyinfoline.com)
  • Coagulopathies - clotting disorders that can cause bleeding within the abdomen as well (as in other sites). (petplace.com)
  • March is Bleeding Disorders Awareness Month. (cdc.gov)
  • Personal health preparedness and planning are important for everyone but essential for people with bleeding disorders. (cdc.gov)
  • Bleeding disorders, such as hemophilia and von Willebrand disease (VWD) , are conditions in which the blood does not clot properly due to a lack of specific clotting factor proteins in the blood. (cdc.gov)
  • As a result, people with bleeding disorders may experience excessive bleeding after an injury or trauma, or may bleed for no apparent reason at all. (cdc.gov)
  • Injections of treatment products, called clotting factor concentrates (or factor), into a vein - a process known as infusion - can help manage and treat bleeding disorders . (cdc.gov)
  • Use CDC's Family Emergency Kit Checklist to help develop an emergency kit for people with bleeding disorders. (cdc.gov)
  • Bleeding Disorders in Women & Girls: Screening, Testing, and Coordinating Care. (cdc.gov)
  • Read real stories of women living with bleeding disorders. (cdc.gov)
UGIB1
  • Upper GI bleeding (UGIB) is defined as bleeding derived from a source proximal to the ligament of Treitz. (medscape.com)
Diagnosis2
  • If you have a bleeding disorder, sharing your diagnosis, as well as directions on how to respond to a bleed with the people you live, work, and socialize with could save your life in an emergency. (cdc.gov)
  • The average time between diagnosis and death is about five years. (georgetakei.com)
Slovenia1
  • Bled Castle is the oldest castle in Slovenia and is now arranged as a exhibition area. (debbzie.com)
Disorder9
  • Von Willebrand disease (VWD) is a bleeding disorder in which the blood does not clot properly. (cdc.gov)
  • VWD is the most common inherited bleeding disorder. (cdc.gov)
  • VWD is diagnosed by asking about a family history of bleeding and running different diagnostic and screening tests to determine if a bleeding disorder is present. (cdc.gov)
  • About 4 in 5 children had a family history of VWD or other bleeding disorder. (cdc.gov)
  • Chédiak-Higashi syndrome (CHS) is a rare autosomal recessive lysosomal disorder characterized by frequent infections, oculocutaneous albinism (OCA), bleeding diathesis, and progressive neurologic deterioration. (medscape.com)
  • It's important that people with a bleeding disorder prepare for their health with a "go bag" containing the medicine and supplies they need to manage and treat a bleed when one occurs. (cdc.gov)
  • There may be times when a person with a bleeding disorder is unable to treat him or herself. (cdc.gov)
  • It is very important for people with a bleeding disorder to take an active role in managing their care and/or the care of their children. (cdc.gov)
  • Take an online bleeding disorder risk assessment to determine if you may be at risk for a bleeding disorder. (cdc.gov)
Coagulopathy1
  • Defense Health Agency (DHA) is seeking a multi-functional diagnostic to determine blood coagulopathy in real time at point-of-care (POC). (sbir.gov)
Stops8
  • Blotting paper is touched to the cuts every 30 seconds until the bleeding stops. (medlineplus.gov)
  • Bleeding normally stops within 1 to 9 minutes. (medlineplus.gov)
  • This is repeated every 30 seconds until the bleeding stops completely (ie, no more blood is being absorbed by the filter). (medscape.com)
  • After the bleeding stops, the blood pressure cuff should be deflated. (medscape.com)
  • Take the stain of the punctured point on a filter paper for 30 seconds and keep taking the stain of blood in 20-second intervals until the bleeding stops. (pharmacyinfoline.com)
  • In many cases of hemoperitoneum caused by abdominal trauma, bleeding stops on its own. (petplace.com)
  • However, it may be the case that the blood flow stops in the second prayer time. (muslimacoaching.com)
  • At 11 pm, the bleeding stops . (muslimacoaching.com)
Hemorrhage3
  • Variceal hemorrhage is not discussed in this article because the underlying mechanisms of bleeding are different and require different therapies. (medscape.com)
  • The underlying mechanisms of nonvariceal bleeding involve either arterial hemorrhage, such as in ulcer disease and mucosal deep tears, or low-pressure venous hemorrhage, as in telangiectasias and angioectasias. (medscape.com)
  • To determine whether the preoperative bleeding time, the most reliable indicator of in vivo platelet dysfunction, can prognosticate excessive postoperative hemorrhage and, hence, the need for infusion of platelet concentrations, we studied blood loss versus bleeding time in 43 patients undergoing coronary bypass grafting. (elsevier.com)
Occur5
  • Optimally, testing should occur at a time remote from events that may raise vWF levels, such as pregnancy, infection, surgery, and strenuous exercise. (medscape.com)
  • These assays avoid the falsely low readings than can occur with ristocetin-dependent methods in patients with some common vWF polymorphisms that do not cause bleeding. (medscape.com)
  • As the intensity of the infection is very severe, sinusitis nose bleeds may occur due to chronic sinusitis. (home-remedies-for-you.com)
  • As mentioned earlier, sinusitis related nose bleeds occur when you have chronic sinusitis. (home-remedies-for-you.com)
  • A situation may occur in which the excuse starts after the prayer time has entered. (muslimacoaching.com)
Capillary1
  • Also known as a pyogenic granuloma, a pregnancy tumor is a noncancerous, rapidly growing mass of capillary blood vessels that bleeds easily. (themasterpiecemom.com)
Uterine2
  • It is a time for a renewal and cleansing of the body through physical removal of the uterine lining. (moonriseritual.com)
  • A uterine aspiration is recommended when patients are bleeding heavily, are anemic, or are medically fragile, and many patients prefer the procedure because it can resolve a miscarriage most quickly. (kasu.org)
Stop The Blee3
  • Blood clots form that stop the bleeding. (petplace.com)
  • This did stop the bleeding sometimes, but never had a scheduled period either. (earthclinic.com)
  • You - which - all of which may be true, but what you would say is, no, we've got to stop the bleeding. (hawaiipublicradio.org)
Capillaries3
  • A bleeding time evaluation is used to measure the primary phase of hemostasis, which involves platelet adherence to injured capillaries and then platelet activation and aggregation. (medscape.com)
  • These tiny capillaries burst due to the pressure, resulting in nose bleeds. (home-remedies-for-you.com)
  • An animal that isn't bled properly (read: quickly and thoroughly) can undergo immense stress, which will raise blood pressure and potentially cause smaller blood vessels (capillaries) to burst. (outdoorlife.com)
Abnormal3
  • The bleeding time can be abnormal when the platelet count is low or the platelets are dysfunctional. (medscape.com)
  • Causes of abnormal bleeding time can be hereditary or acquired. (medscape.com)
  • Abnormal assays for factors II and VII in patients with unexplained bleeding and a normal PT, partial thromboplastin time, or INR, as determined by hospital or commercial laboratory tests. (cdc.gov)
Nose17
Heavily4
  • Weeks after her miscarriage was confirmed, Christina Zielke started bleeding heavily while on a trip out of town. (ijpr.org)
  • If you take it when you're bleeding heavily, it may also reduce your flow. (healthline.com)
  • A passenger was found "heavily bleeding" on-board an Emirates flight from Dubai to Hyderabad last week, a spokesman for the airliner told Al Arabiya News on Monday. (alarabiya.net)
  • A passenger was found bleeding heavily in the restroom just before descent by cabin crew" on April 4, the Emirates spokesman said in a statement sent to Al Arabiya News. (alarabiya.net)
Gingival1
  • Oral manifestations include spontaneous gingival bleeding, petechiae or hematomas of the mucosa, palate and tongue. (bvsalud.org)
Profusely2
  • Her miscarriage left her bleeding profusely. (ijpr.org)
  • During this time, the victim was lying unconscious and her head was bleeding profusely. (cdc.gov)
Prothrombin time2
  • Prolonged prothrombin time (PT) and international normalized ratio (INR) (24 to 72 hours after exposure) persisting for weeks to months, as determined by hospital laboratory tests. (cdc.gov)
  • Here, using the VetScan VSpro veterinary point-of-care platform, we developed reference intervals in both juvenile and adult strain 13/N guinea pigs for three coagulation parameters: prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen. (cdc.gov)
Chronic1
  • It can be used to treat a variety of chronic pain conditions, cancer types, infections, and Heavy Bleeding. (sankalphospital.in)
Complications4
  • Characteristics, complications, and sites of bleeding among infants and toddlers less than 2 years of age with VWD. (cdc.gov)
  • Demographics, pre- injury anti-thrombotics, operative characteristics, pre- and post-operative VTE prophylaxis, and post-operative complications , including spinal bleeding , and VTE were collected. (bvsalud.org)
  • Univariate analysis was performed, comparing baseline characteristics, VTE prophylaxis timing, and complications between the early and late groups. (bvsalud.org)
  • By the time she completed her residency in emergency medicine, Dr. Andreia Alexander had seen all manner of injuries and complications - everything from kidney stones and broken bones to stab wounds and seizures. (kasu.org)
Aggregation2
  • This study investigated the in vivo effect of alum on platelet aggregation and bleeding time in rabbits. (who.int)
  • contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)
Castle2
  • The history of the castle reaches back to 1004 when the German Emperor Henry II gave his estate at Bled to Bishop Albuin of Bixen. (debbzie.com)
  • Our first stop is the stunning lakeside city of Bled , where we will take a guided tour of its spectacular hanging castle . (civitatis.com)
Menstruation4
  • How Many Days of Bleeding Are Typical During Menstruation? (verywellhealth.com)
  • During the first few years after the start of menstruation, you may experience unpredictable bleeding patterns. (verywellhealth.com)
  • Then bleeding, which I attributed to irregular menstruation. (who.int)
  • This remedy does really work for balancing hormones, headaches, cramping and heavy bleeding during menstruation especially when peri menopause, I am 48 yrs old. (earthclinic.com)
Prolong1
  • The patient should not take aspirin, NSAIDs, or alcohol for 7 days prior to the test, since they will prolong the bleeding time and lead to false-positive results. (medscape.com)
Clinically2
  • In this retrospective cohort study , VTE prophylaxis timing was not associated with clinically significant post-operative spinal bleeding and VTE in trauma patients . (bvsalud.org)
  • A clinically compatible case in which a high index of suspicion (credible threat or patient history regarding location and time) exists for a long-acting anticoagulant exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. (cdc.gov)
Blood clots1
  • If blood clots are dislodged, the bleeding may start again. (petplace.com)
Anticoagulant2
  • When anticoagulation has been reversed due to a bleeding event, it is challenging to decide when it is appropriate to restart the anticoagulant that caused the bleed. (ashpadvantage.com)
  • Given the potentially life-threatening consequences of anticoagulant-related bleeding, it seems counterintuitive to restart the medication that caused harm to the patient. (ashpadvantage.com)
Heavy11
  • TIME 2 BLEED is a non-stim formula that elevates nitric oxide levels to the NEXT LEVEL while increasing your lactic acid threshold to help you push, pull and lift that HEAVY ASS WEIGHT. (strengthcartel.com)
  • Heavy bleeding is a sign to contact your healthcare provider. (verywellhealth.com)
  • Hi I have fibroids n I m suffering from heavy bleeding. (westonaprice.org)
  • Can you think of some times where you were eager and ready to bleed and start a new cycle after experiencing heavy energy? (moonriseritual.com)
  • On the drive to Ohio, I had some really heavy bleeding - to the point [that] we had to stop and clean out the car and change all the clothes," she says. (ijpr.org)
  • One nurse mentioned in passing that a D&C is sometimes needed to get heavy bleeding to stop, but Zielke says she wasn't offered one, nor was she given any other treatment, not even IV fluids or pain medication. (ijpr.org)
  • A skipped period can also cause the lining to build up, leading to heavy bleeding. (healthline.com)
  • When bleeding is heavy , it may last longer, disrupting your everyday life. (healthline.com)
  • Heavy bleeding can also cause fatigue and increase your risk for other health concerns, such as anemia . (healthline.com)
  • When Isha enters, the bleeding is still heavy, and she cannot make wudu and pray without it exiting. (muslimacoaching.com)
  • The side effects might be worth putting up with if it helps me with the heavy bleeding and the pain and the moods. (sugarbutch.net)
Acute1
  • Acute gastrointestinal (GI) bleeding is a potentially life-threatening abdominal emergency that remains a common cause of hospitalization. (medscape.com)
Occurs1
  • Instead, the person must see what happens in the next prayer time , and the ruling will be based upon what occurs then. (muslimacoaching.com)
Narrow Head3
  • New bleed song just in time for that Detroit show W/ narrow head in a week or so! (20buckspin.com)
  • In advance of the band's upcoming Fall tour with Narrow Head, Dallas, Texas based Bleed release the new track 'Killing Time', their first new music made public since the release of the 'Somebody's Closer' EP. (20buckspin.com)
  • All three bands, Narrow Head, Temple of Angels, and Bleed, brought me back to 2004 with tones that blend alt metal distortion with the inherent darkness of post-grunge. (fulltimeaesthetic.com)
Thrombosis1
Prophylaxis2
  • Little is known regarding appropriate timing for chemical venous thromboembolism (VTE) prophylaxis initiation in operative traumatic spinal injuries . (bvsalud.org)
  • We hypothesized that the incidence of post-operative bleeding leading to neurological decline or re-operation would not increase in patients who received early VTE prophylaxis (≤2 days post- surgery ) as compared to those who received late VTE prophylaxis (≥ 3 days post- surgery ). (bvsalud.org)
Normal6
  • and longer-than-normal bleeding after injury, surgery, and dental work. (cdc.gov)
  • Still, it's not normal to bleed for more than seven days every month or not bleed at all once you have passed menarche . (verywellhealth.com)
  • If the cat has normal clotting parameters, bleeding into the abdomen will oftentimes stop on its own. (petplace.com)
  • The bleeding time, which had been recommended as an essential screening test before all cardiopulmonary bypass procedures, need not be performed as a preoperative screen in otherwise healthy patients with no history of bleeding abnormalities and a normal coagulation profile. (elsevier.com)
  • At the same time, STRONG was planned to provide important data on age and sex matched normal values of controls and retinal vein occlusion (RVO) patients and the natural course of iCRVO and NVG in a very large and well-investigated cohort. (europa.eu)
  • But there is nothing normal about the "lockdown" mode many of our people are facing, and even we experienced telecommuters are having to find some new ways to manage work, family, and health in this crazy, unprecedented time. (clearpeople.com)
Lasts1
Death10
  • As the documentary jumps around to different people, devices and experts, we return again and again to the horrifying story of this mail carrier, who came to find that her body was rejecting the coil, which led her to nearly bleed to death. (browardpalmbeach.com)
  • BLEEDING RED gelingt es vielfältige Einflüsse zu einer eisenharten blackened-Death-Legierung zu verschmelzen. (time-for-metal.eu)
  • Moon Time can be viewed as a mini ego death every time we bleed. (moonriseritual.com)
  • A victim can bleed to death in a short time. (hunter-ed.com)
  • Leukemia at that time was a horrible illness-a death sentence," Freireich said in a 2015 interview . (the-scientist.com)
  • Children bled to death. (the-scientist.com)
  • Despite skepticism from his colleagues, Freireich believed that leukemia patients bled to death due to a lack of blood-dwelling cell fragments called platelets. (the-scientist.com)
  • If he blows it up slowly that could kill it for good as competitors get time to bleed off the users and a slow death makes Twitter less and less relevant over time until no one cares anymore. (cantechletter.com)
  • Often times, these conversations are around death or people who are dying. (georgetakei.com)
  • Some animals did not survive until day 133, but they were sampled by using the same procedures until time of death. (cdc.gov)
Suggests1
  • Perhaps, suggests Wharton marketing professor Peter S. Fader , the AOL Time Warner strategy wouldn't have worked even if the Internet bubble had not burst and the economy had not skidded into recession. (upenn.edu)
Cessation2
  • Hemostasis is a sequence of events that leads to bleeding cessation via the formation of a fibrin-platelet hemostatic plug. (medscape.com)
  • The amount of time it take for a cessation of bleeding. (fpnotebook.com)
Superficial1
  • We aimed to stop superficial bleeding from minor abra- elucidate if the in vitro properties of alum sions or cuts. (who.int)
Content1
  • When America Online bought Time Warner for $103.5 billion in January 2001, the plan was to meld new-economy Internet prowess with old-economy content and cutting-edge broadband delivery. (upenn.edu)
Excessive1
Anticoagulation2
  • While "c" is the correct answer, re-initiation of anticoagulation is often overlooked after a major bleed. (ashpadvantage.com)
  • Therefore, while there are often clear risks to restarting oral anticoagulation after a bleeding event, there are also likely clear benefits that must be considered. (ashpadvantage.com)
Congenital fibrinogen deficiency: MedlinePlus Medical Encyclopedia
Congenital fibrinogen deficiency: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Platelet Tests: MedlinePlus Medical Test
Platelet Tests: MedlinePlus Medical Test (medlineplus.gov)
Browsing by Subject Bleeding Time
Browsing by Subject "Bleeding Time" (extranet.who.int)
Acute Anemia: Practice Essentials, Etiology, Clinical Presentation
Acute Anemia: Practice Essentials, Etiology, Clinical Presentation (emedicine.medscape.com)
Participants by Diagnosis, 2014 Community Counts Registry Report | CDC
Participants by Diagnosis, 2014 Community Counts Registry Report | CDC (cdc.gov)
Platelet Disorders: Overview of Platelet Disorders, Pathophysiology of Platelet Disorders, Autoimmune Thrombocytopenias
Platelet Disorders: Overview of Platelet Disorders, Pathophysiology of Platelet Disorders, Autoimmune Thrombocytopenias (medscape.com)
Factor X Deficiency Workup: Laboratory Studies
Factor X Deficiency Workup: Laboratory Studies (medscape.com)
Ginnifer Goodwin Archives - Give Me My Remote : Give Me My Remote
Ginnifer Goodwin Archives - Give Me My Remote : Give Me My Remote (givememyremote.com)
Essential Thrombocytosis Workup: Approach Considerations, Histologic Findings, Blood Studies
Essential Thrombocytosis Workup: Approach Considerations, Histologic Findings, Blood Studies (medscape.com)
Upper Gastrointestinal Bleeding (UGIB): Practice Essentials, Background, Etiology
Upper Gastrointestinal Bleeding (UGIB): Practice Essentials, Background, Etiology (medscape.com)
Bandabsagen für das Summer Breeze
Bandabsagen für das Summer Breeze (burnyourears.de)
Ehlers-Danlos Syndrome: Practice Essentials, Background, Pathophysiology
Ehlers-Danlos Syndrome: Practice Essentials, Background, Pathophysiology (medscape.com)
(emedicine.medscape.com)
Community Counts Registry for Bleeding Disorders Surveillance | Hemophilia | CDC
Community Counts Registry for Bleeding Disorders Surveillance | Hemophilia | CDC (cdc.gov)
Diagnosis of Hemophilia | CDC
Diagnosis of Hemophilia | CDC (cdc.gov)
Triklo Side Effects: Common, Severe, Long Term - Drugs.com
Triklo Side Effects: Common, Severe, Long Term - Drugs.com (drugs.com)
Professor Peter Collins - People - Cardiff University
Professor Peter Collins - People - Cardiff University (cardiff.ac.uk)
DailyMed - KETOROLAC TROMETHAMINE tablet, film coated
DailyMed - KETOROLAC TROMETHAMINE tablet, film coated (dailymed.nlm.nih.gov)
Pediatric Antiphospholipid Antibody Syndrome Medication: Antiplatelet agents, Anticoagulants, Immunomodulators, Vasodilators,...
Pediatric Antiphospholipid Antibody Syndrome Medication: Antiplatelet agents, Anticoagulants, Immunomodulators, Vasodilators,... (medscape.com)
(emedicine.medscape.com)