Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Blood Pressure Determination: Techniques for measuring blood pressure.Diagnostic Techniques and Procedures: Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.Platelet Activation: A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.Ischemic Preconditioning: A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.Emergency Treatment: First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.Emergency Medicine: The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.Emergency Service, Hospital: Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.Emergency Medical Services: Services specifically designed, staffed, and equipped for the emergency care of patients.Hospital Rapid Response Team: Multidisciplinary team most frequently consisting of INTENSIVE CARE UNIT trained personnel who are available 24 hours per day, 7 days per week for evaluation of patients who develop signs or symptoms of severe clinical deterioration.Emergency Medical Service Communication Systems: The use of communication systems, such as telecommunication, to transmit emergency information to appropriate providers of health services.Gene Duplication: Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES.Lawyers: Persons whose profession is to give legal advice and assistance to clients and represent them in legal matters. (American Heritage Dictionary, 3d ed)Child Advocacy: Promotion and protection of the rights of children; frequently through a legal process.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Thymus Extracts: Extracts of the thymus that contain specific, but uncharacterized factors or proteins with specific activities; three distinct substances are already known: thymotoxin, thymin and thymosin.Thymopentin: Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Libraries, MedicalDrug Discovery: The process of finding chemicals for potential therapeutic use.Gift Giving: The bestowing of tangible or intangible benefits, voluntarily and usually without expectation of anything in return. However, gift giving may be motivated by feelings of ALTRUISM or gratitude, by a sense of obligation, or by the hope of receiving something in return.Technology, Pharmaceutical: The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.Libraries: Collections of systematically acquired and organized information resources, and usually providing assistance to users. (ERIC Thesaurus, http://www.eric.ed.gov/ accessed 2/1/2008)Tissue Adhesives: Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.Enbucrilate: A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.Cyanoacrylates: A group of compounds having the general formula CH2=C(CN)-COOR; it polymerizes on contact with moisture; used as tissue adhesive; higher homologs have hemostatic and antibacterial properties.Embolization, Therapeutic: A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.Intracranial Arteriovenous Malformations: Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.Polyvinyl Alcohol: A polymer prepared from polyvinyl acetates by replacement of the acetate groups with hydroxyl groups. It is used as a pharmaceutic aid and ophthalmic lubricant as well as in the manufacture of surface coatings artificial sponges, cosmetics, and other products.Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.Antilymphocyte Serum: Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.Methyl n-Butyl Ketone: An industrial solvent which causes nervous system degeneration. MBK is an acronym often used to refer to it.Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Vagina: The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)Hematocolpos: A blood-filled VAGINA that is obstructed.Hymen: A thin fold of MUCOUS MEMBRANE situated at the orifice of the vagina.Vaginal Neoplasms: Tumors or cancer of the VAGINA.Hydrocolpos: A fluid-filled VAGINA that is obstructed.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Genitalia, Female: The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.Vaginal Diseases: Pathological processes of the VAGINA.Uterine Prolapse: Downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.Physicians: Individuals licensed to practice medicine.

Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis. (1/411)

The small molecule direct thrombin inhibitor L-374,087 was characterized across species in an in vitro activated partial thromboplastin clotting time (aPTT) assay and in vivo in rhesus monkey and dog thrombosis models. In vitro in rhesus, dog, and human plasma, L-374,087 concentrations eliciting 2-fold increases in aPTT were 0.25, 1.9, and 0.28 microM, respectively. In anesthetized rhesus monkeys, 300 microgram/kg bolus plus 12 microgram/kg/min and 300 microgram/kg bolus plus 30 microgram/kg/min L-374,087 i.v. infusions significantly reduced jugular vein thrombus extension, with both regimens limiting venous thrombus extension to 2-fold that of baseline thrombus mass compared with a 5-fold extension observed in the vehicle control group. Antithrombotic efficacy in the rhesus with the lower-dose regimen was achieved with 2.3- to 2.4-fold increases in aPTT and prothrombin time. In a conscious instrumented dog model of electrolytic vessel injury, the oral administration of two 10 mg/kg L-374,087 doses 12 h apart significantly reduced jugular vein thrombus mass, reduced the incidence of and delayed time to occlusive coronary artery thrombosis, and significantly reduced coronary artery thrombus mass and ensuing posterolateral myocardial infarct size. Antithrombotic efficacy in the dog was achieved with 1.6- to 2.0-fold increases in aPTT at 1 to 6 h after oral dosing with L-374,087. These results indicate significant antithrombotic efficacy against both venous and coronary arterial thrombosis with L-374,087 with only moderate elevations in aPTT or prothrombin time. The oral efficacy of L-374,087 characterizes this compound as a prototype for the further development of orally active direct thrombin inhibitors.  (+info)

Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. (2/411)

Agonists induce inside-out alphaIIbbeta3 signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in further platelet stimulation. Because the Syk tyrosine kinase is activated during both phases of integrin signaling, we evaluated its role in alphaIIbbeta3 function in murine platelets rendered null for Syk by gene targeting and in human platelets incubated with piceatannol, a tyrosine kinase inhibitor reportedly selective for Syk. Both Syk null murine platelets and piceatannol-treated human platelets exhibited a partial, but statistically significant defect in activation of alphaIIbbeta3 by adenine diphosphate (ADP) +/- epinephrine as assessed by fibrinogen binding. Syk null platelets adhered normally to immobilized fibrinogen, and mice with these platelets exhibited normal tail bleeding times. In contrast, piceatannol treatment of human platelets completely inhibited platelet adhesion to immobilized fibrinogen. The discrepancy in extent of integrin dysfunction between murine and human platelet models may be due to lack of specificity of piceatannol, because this compound inhibited the activity of Src and FAK as well as Syk and also reduced tyrosine phosphorylation of multiple platelet proteins. These results provide genetic evidence that Syk plays a role in alphaIIbbeta3 signaling in platelets and pharmacological evidence that, although piceatannol also inhibits alphaIIbbeta3 signaling, it does so by inhibtion of multiple protein tyrosine kinases.  (+info)

Suppression of platelet aggregation by Bordetella pertussis adenylate cyclase toxin. (3/411)

The effect of Bordetella pertussis adenylate cyclase toxin (ACT) on platelet aggregation was investigated. This cell-invasive adenylate cyclase completely suppressed ADP (10 microM)-induced aggregation of rabbit platelets at 3 micrograms/ml and strongly suppressed thrombin (0. 2 U/ml)-induced aggregation at 10 micrograms/ml. The suppression was accompanied by marked increase in platelet intracellular cyclic AMP (cAMP) content and was diminished by the anti-ACT monoclonal antibody B7E11. A catalytically inactive point mutant of ACT did not show the suppressive effect. Since an increase of cAMP content is a known cause of platelet dysfunction, these results indicate that the observed platelet inactivation was due to the catalytic activity of ACT through increase of intracellular cAMP.  (+info)

Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. (4/411)

Endothelial nitric oxide synthase (eNOS) has been identified in human platelets. Although platelet-derived nitric oxide (NO) has been shown to inhibit platelet recruitment in vitro, its role in the regulation of the hemostatic response in vivo has not been characterized. To define the role of platelet-derived NO in vivo, we studied mice that lacked a functional eNOS gene (NOSIII). Surface P-selectin expression in platelets from eNOS-deficient mice was not significantly altered; however, bleeding times were markedly decreased in eNOS-deficient versus wild-type mice (77.2+/-3 versus 133.4+/-3 seconds, P<0.00005). To determine the contribution of endothelium- versus platelet-derived NO to the bleeding time, isolated platelets from either eNOS-deficient or wild-type mice were transfused into a thrombocytopenic eNOS-deficient mouse and the bleeding time was measured. The bleeding times in mice transfused with eNOS-deficient platelets were significantly decreased compared with mice transfused with wild-type platelets (Deltableeding time, -24.6+/-9.1 and -3.4+/-5.3 seconds, respectively; P<0.04). Platelet recruitment was studied by measuring serotonin release from a second recruitable population of platelets that were added to stimulated platelets at the peak of NO production. There was 40.3+/-3.7% and 52. 0+/-2.1% serotonin release for platelets added to wild-type or eNOS-deficient platelets, respectively (P<0.05). In summary, mice that lacked eNOS had markedly decreased bleeding times even after endothelial NO production was controlled. These data suggest that the lack of platelet-derived NO alters in vivo hemostatic response by increasing platelet recruitment. Thus, these data support a role for platelet-derived NO production in the regulation of hemostasis.  (+info)

Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production. (5/411)

1. The effects of ethyl alcohol and wine (red and white) on haemostatic parameters and experimental thrombosis were studied in rats; NO was evaluated as a possible mediator of these effects. 2. We found that red wine (12% alcohol) supplementation (8.4 +/- 0.4 ml d-1 in drinking water, for 10 days) induced a marked prolongation of 'template' bleeding time (BT) (258 +/- 13 vs 132 +/- 13 s in controls; P < 0.001), a decrease in platelet adhesion to fibrillar collagen (11.6 +/- 1.0 vs 32.2 +/- 1.3%; P < 0.01) and a reduction in thrombus weight (1.45 +/- 0.33 vs 3.27 +/- 0.39 mg; P < 0.01). 3. Alcohol-free red wine showed an effect similar to red wine. In contrast, neither ethyl alcohol (12%) nor white wine (12% alcohol) affected these systems. 4. All these effects were also observed after red wine i.v. injection (1 ml kg-1 of 1:4 dilution) 15 min before the experiments. 5. The effects of red wine were prevented by the NO inhibitor, N omega nitro-L-arginine-methyl ester (L-NAME). L-arginine, not D-arginine, reversed the effect of L-NAME on red wine infusion. 6. Red wine injection induced a 3 fold increase in total radical-trapping antioxidant parameter values of rat plasma with respect to controls, while white wine and alcohol did not show any effect. 7. Our study provides evidence that red wine modulates primary haemostasis and prevents experimental thrombosis in rats, independently of its alcohol content, by a NO-mediated mechanism.  (+info)

Magnitude and time course of impaired primary haemostasis after stopping chronic low and medium dose aspirin in healthy volunteers. (6/411)

Aspirin ingestion within the previous 7-10 days is often considered a relative contraindication to performing invasive procedures. However, aspirin is an important component of many patients' treatment and withholding therapy for this time may be dangerous. To measure both the magnitude of the impairment in primary haemostasis induced by aspirin and how much recovery of platelet function occurs within 48 h of stopping aspirin, we studied serial changes in bleeding time (BT) in a randomized, double-blind, placebo-controlled study. Fifty-two healthy volunteers had BT performed before and at 2, 9, 24 and 48 h after a 7-day course of either aspirin 75 mg, 300 mg or placebo. The main outcome recorded was BT at each time. Nearly 25% of subjects had extended BT to more than 10 min, but no BT were greater than 10 min, 48 h after stopping aspirin. There was a small but statistically significant (P < 0.01) difference between the 48-h and baseline BT in both aspirin groups (49 and 64 s in the 75 mg and 300 mg groups, respectively). There was no difference in the magnitude or time course of effect between low and medium dose aspirin (P = 0.392 and P = 0.797, respectively). We conclude that despite considerable inter-individual variability in the magnitude of aspirin effect on primary haemostasis, the time course of effect was consistent. In healthy volunteers, the defect in primary haemostasis had largely disappeared 48 h after the last dose.  (+info)

Neither endogenous nor inhaled nitric oxide influences the function of circulating platelets in healthy volunteers. (7/411)

Experimental models have indicated prothrombotic effects of inhibition of nitric oxide (NO) production, and anti-thrombotic effects of inhaled NO, but the influence of NO on platelet function in vivo in humans is not well established. We therefore investigated the effects of systemic inhibition of NO synthesis by N(G)-monomethyl-L-arginine (L-NMMA) and of NO inhalation on platelet function in vivo. On two occasions, L-NMMA (13.5 mg/kg) or saline infusion was administered to 14 healthy volunteers in a double-blind cross-over study. After a 30 min infusion of L-NMMA or placebo, NO inhalation (30 p.p.m) was added during the remaining 30 min of infusion, on both occasions. Measurements included filtragometry ex vivo (reflecting platelet aggregability), flow-cytometric evaluation of platelets in whole blood (fibrinogen binding and P-selectin expression), plasma beta-thromboglobulin (reflecting platelet secretion), cGMP in platelets and plasma, thrombin generation markers (thrombin fragment 1+2 and thrombin-antithrombin complexes) in plasma, and bleeding time. L-NMMA increased blood pressure and decreased heart rate. NO inhalation did not influence blood pressure or heart rate, but caused a 3-fold elevation in plasma cGMP levels (P<0.001). Neither L-NMMA nor NO influenced filtragometry readings or flow-cytometric determinations of platelet fibrinogen binding and P-selectin expression. Furthermore, plasma beta-thromboglobulin, platelet cGMP and thrombin generation markers were not influenced by either treatment. Bleeding time was not influenced by L-NMMA compared with placebo, but was increased by approximately 25% during NO inhalation (P<0.01), whether NO synthesis had been inhibited or not. The prolongation of bleeding time by inhaled NO was not accompanied by any effect on the platelet variables assessed. The present results indicate that circulating platelets are not influenced by endogenous or inhaled NO, presumably due to the rapid inactivation of NO in the blood. This does not exclude possible effects of endothelial NO in the interface between the blood and the vessel wall.  (+info)

Prognostic value of serum hepatocyte growth factor in patients with acute coronary syndromes. (8/411)

The present study examined whether or not hepatocyte growth factor (HGF), an endothelium-specific growth factor that stimulates regeneration of the endothelium, is increased or has a prognostic significance in patients with acute coronary syndromes. HGF was measured in 106 patients with coronary artery disease (20 stable effort angina, 12 unstable angina without adverse events, 24 unstable angina with adverse events and 50 acute myocardial infarction) on admission and 21 normal volunteers. The measurements in all patients were recorded before administration of heparin, and in acute myocardial infarction patients they were recorded from days 2 to 6 after heparin discontinuation on day 1. HGF levels (ng/ml) were 0.30+/-0.06 for the controls, 0.31+/-0.08 for stable effort angina patients, 0.31+/-0.08 for unstable angina patients without adverse events, 0.40+/-0.20 for unstable angina patients with adverse events and in acute myocardial infarction patients they were 0.45+/-0.18 on day 0, 0.57+/-0.45 on day 2, 0.50+/-0.35 on day 3, 0.48+/-0.32 on day 4, 0.44+/-0.20 on day 5, and 0.38+/-0.14 on day 6. HGF plays a crucial role in the restoration of injured endothelial cells and is a predictor of adverse events in patients with acute coronary syndromes.  (+info)

*No Time to Bleed (song)

"No Time to Bleed" - 2:22 "No Time to Bleed (Big Chocolate Remix)" - 4:57 Suicide Silence Alex Lopez - drums Mark Heylmun - lead ... No Time to Bleed - Single by Suicide Silence iTunes SUICIDE SILENCE To Release 'No Time To Bleed' Seven-Inch Single ... "No Time to Bleed" is a song by American deathcore band, Suicide Silence. The song was released as the third and final single ... Blabbermouth Suicide Silence - No Time To Bleed (Single) Century Media. ...

*Bleeding Through (Once Upon a Time)

Ihnat, Gwen (April 20, 2014). "ONCE UPON A TIME: "Bleeding Through"". The A.V. Club. Retrieved April 20, 2014. "Bleeding ... "Bleeding Through" is the eighteenth episode of the third season of the American fantasy drama series Once Upon a Time, and the ... "Once Upon a Time": Bleeding Through "Sunday Final Ratings: 'The Amazing Race' Adjusted Up; 'Dateline', 'American Dream Builders ... Gold's Brain: Zelena is planning to create a time-travel spell, in which Zelena is planning to go back to the past and prevent ...

*Leech

Bleeding may continue for some time, due to the leech's hirudin. Bleeding time will vary, with location, from a few hours to ... Anticlotting medications also affect the bleeding time. Applying pressure can reduce bleeding, although blood loss from a ... In modern times, leeches are used medically in procedures such as the reattachment of body parts and reconstructive and plastic ... In the crop, some[which?] blood-sucking species of leech can store up to five times the body mass of blood. The leech produces ...

*Saw palmetto extract

In a case report, a patient taking saw palmetto extract had increased bleeding time during surgery. Bleeding time returned to ... Use may increase the risk of bleeding or affect sex hormones, and concurrent use of other drugs with similar action should be ... When used in combination with an anticoagulant or antiplatelet drug, saw palmetto extract can increase the risk of bleeding by ... because there was evidence from earlier literature that such pre-treatment reduced operative bleeding. The trial reported no ...

*Latamoxef

Weitekamp MR, Aber RC (1983). "Prolonged bleeding times and bleeding diathesis associated with moxalactam administration". JAMA ... Latamoxef has been associated with prolonged bleeding time, and several cases of coagulopathy, some fatal, were reported during ... Brown RB, Klar J, Lemeshow S, Teres D, Pastides H, Sands M (1986). "Enhanced bleeding with cefoxitin or moxalactam. Statistical ...

*Clotting time

Dg, Dayyal (2016). "Bleeding Time (BT) and Clotting Time (CT)". ISSN 2521-5760. Retrieved 2017-10-26. Silvestri, Linda (2014). ... Prothrombin time (PT) is used for warfarin studies and the normal values differ for men and women. PT time for adult males' ... Clotting time is the time required for a sample of blood to coagulate in vitro under standard conditions. There are various ... Normal value of clotting time is 8 to 15 minutes. For the measurement of clotting time by test tube method, blood is placed in ...

*Etamsylate

It has been shown to reduce bleeding time and blood loss from wounds. This appears to relate to increased platelet aggregation ... Etamsylate limits capillary bleeding through its action on hyaluronic acid and initial studies showed a reduction in ... Prophylaxis and control of haemorrhages from small blood vessels, neonatal intraventricular haemorrhage, capillary bleeding of ... secondary bleeding due to thrombocytopenia or thrombocytopathia, hypocoagulation, prevention of periventricular hemorrhages in ...

*Hermansky-Pudlak syndrome

Wijermans, Pw; Van Dorp, Db (March 1989). "Hermansky-Pudlak syndrome: correction of bleeding time by 1-desamino-8D-arginine ... Prolonged bleeding has been reported following strabismus surgery in patients with the syndrome. The course of HPS has been ... Since platelets are necessary for blood clotting, individuals will bruise and bleed easily.[citation needed] Cellular storage ... Since patients with the syndrome have bleeding tendencies, intraoperative, perioperative, and postoperative hemorrhages should ...

*Hypoprothrombinemia

No abnormality in fibrinogen, liver function test, and bleeding time. However, prothrombin levels were less than 1% so patient ... Bleeding of the membrane mucus lining inside of the mouth. Soft tissue bleeding. Hemarthrosis - Bleeding in joint spaces. ... Lab exams revealed prolonged prothrombin time (PT) of 34.4 and acquired partial thromboplastin time (aPTT) of 81.7, as well as ... intracranial bleeding, postoperative bleeding, and umbilical cord hemorrhage, which may also occur depending on the severity, ...

*Fish oil

... among other effects these people had prolonged bleeding times, i.e., slower blood clotting. The liver and liver products (such ... Oils from these fish have a profile of around seven times as much omega-3 oils as omega-6 oils. Other oily fish, such as tuna, ... The average was equal to 1.85 of the TWI and the high value equal to 7.69 times the TWI for methylmercury; also expressible as ... A co-author of the study said to Time, "Our analysis suggests that there is currently no evidence that omega-3 fatty acid ...

*Helge Stormorken

"Effect of linseed oil on platelet adhesiveness and bleeding-time in patients with coronary heart-disease". Lancet. 2 (7420): ... By the time of his 85th birthday he had 275 academic publications. He was decorated with the Royal Norwegian Order of St. Olav ... Haverkate et al., de Gruyter & Co, Berlin NB Årstall Stormorken, H; Gogstad, G; Solum, NO (15 February 1983). "A new bleeding ... He established the cause of a worldwide fatal bleeding disease in piglets leading to its eradication. He described the ...

*Glycogen storage disease type I

Bleeding time may be normalized with 1-2 days of glucose loading, and improved with ddavp. During surgery, iv fluids should ... By the time the child is standing and walking, the hepatomegaly may be severe enough to cause the abdomen to protrude. The ... Triglyceride levels in GSD I can reach several times normal and serve as a clinical index of "metabolic control". Hyperuricemia ... A critical blood specimen obtained at the time of hypoglycemia typically reveals a mild metabolic acidosis, high free fatty ...

*Pseudo gray platelet syndrome

Bleeding time, activated partial thromboplastin time, prothrombin time, and euglobulin lysis time were within normal limits. ... A brother had no reported bleeding tendencies. Platelets from the mother, sisters, and a daughter were normal in number and ... Patients with the GPS are affected by mild to moderate bleeding tendencies. Cockbill SR, Burmester HB, Heptinstall S (October ... who reported a 25-year-old woman with a history of mild bruising and bleeding. Another case was described in Japan in 2002. ...

*Pepducin

An anti-PAR4 pepducin extended bleeding time in mice and protected against systemic platelet activation and thrombosis. A CXCR4 ...

*Vorapaxar

... or bleeding time. Vorapaxar can be stored at 20-25 °C(68-77 °F). It is best to store vorapaxar in original packaging with the ... There was an increase in moderate or severe bleeding, but no statistically significant increase in fatal bleeding. Vorapaxar ... If the person has severe hepatic impairment, vorapaxar is not recommended due to the risk of bleeding. Vorapaxar is a new anti- ... However, there was increased risk of major bleeding. A trial published in February 2012, found no change in all cause mortality ...

*Batroxobin

At low dose the batroxobin significantly shortened bleeding times and clotting times in mice and rats. So a low dose of ... coagulation time, activated partial thromboplastin time, prothrombin time and thrombin time. The long-term effects of ... Furthermore, batroxobin didn't affect the prothrombin time, thrombin time or activated partial thromboplastin time, but did ... In rabbits injection of batroxobin lead to a decrease in blood loss in liver wounds and shortened the bleeding time, ...

*Discovery and development of direct Xa inhibitors

Separation of its antithrombotic effects from its prolongation of bleeding time". European Journal of Pharmacology. 339 (2-3): ... At the same time, Glu-15 located outside the reactive site of antistasin fits to positively charged residues on the surface of ... The biggest problem regarding Xa inhibitors is the lack of immediate reversibility when bleeding is occurring in patients. ... Link and his student Wilhelm Schoeffel started an intense investigation to find the substance causing the internal bleeding. It ...

*Platelet

Developed by Duke in 1910 and bearing his name, it measured the time for bleeding to stop from a standardized wound in the ear ... bleeding into mucous membranes causing bleeding gums, nose bleed, and gastrointestinal bleeding; menorrhagia; and intraretinal ... All of the following suggest platelet bleeding, not coagulation bleeding: the bleeding from a skin cut such as a razor nick is ... A normal bleeding time reflects sufficient platelet numbers and function plus normal microvasculature. In the Multiplate ...

*Andrew Conway Ivy

In addition, his work resulted in new types of procedures including the "Ivy bleeding time" for diagnosing clotting ... Ivy was considered "one of the nation's top physiologists" and "the conscience of U.S. Science" at the time of the Nuremberg ... While considered the foremost medical professional during the time of the Nuremberg trials, later on his life, he would come to ... when the committee had not met at that time. As a physician, Ivy did extensive research on cancer physiology and ...

*Seratrodast

... time to occlusion and bleeding time. Seratrodast has no effect on prothrombin time and activated partial thromboplastin time, ...

*Platelet storage pool deficiency

The diagnosis of this condition can be done via the following: Flow cytometry Bleeding time analysis This condition may involve ... Individuals with ADP deficient storage pool disease present a prolonged bleeding time due to impaired aggregation response to ... Unusual bleeding(after surgical procedure) Anemia Decrease mean platelet volume Myelodysplasia The condition of platelet ... deficiency has no treatment however management consists of antifibrinolytic medications if the individual has unusual bleeding ...

*Valproate

... may increase warfarin concentration and prolong bleeding time. Zidovudine: may increase zidovudine serum concentration and lead ... By RONI CARYN RABIN, New York Times, April 15, 2009 Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen ... Valproate causes birth defects; exposure during pregnancy is associated with about three times as many major abnormalities as ... Bleeding Low blood platelets Encephalopathy Suicidal behavior and thoughts Low body temperature Valproic acid has a black box ...

*Glanzmann's thrombasthenia

... and the bleeding time is significantly prolonged. Characteristically, there is increased mucosal bleeding: menorrhagia easy ... bruising epistaxis gingival bleeding gastrointestinal bleeding postpartum bleeding increased bleeding post-operatively. The ... Therapy involves both preventive measures and treatment of specific bleeding episodes. Dental hygiene lessens gingival bleeding ... does not normalize the bleeding time in Glanzmann's thrombasthenia but anecdotally improves hemostasis Hormonal contraceptives ...

*Ketorolac

Lab tests, such as liver function tests, bleeding time, BUN, serum creatinine and electrolyte levels are often used and help to ... gastrointestinal bleeding, alcohol intolerance, renal impairment, cerebrovascular bleeding, nasal polyps, angioedema, and ... Though uncommon, potentially fatal adverse effects are stroke, myocardial infarction, GI bleeding, Stevens-Johnson Syndrome, ...

*Coagulation

Other: TCT, bleeding time, mixing test (whether an abnormality corrects if the patient's plasma is mixed with normal plasma), ... Hageman factor, now known as factor XII, was identified in 1955 in an asymptomatic patient with a prolonged bleeding time named ... this may increase bleeding risk. Deficiency of Vitamin K may also contribute to bleeding disorders because clotting factor ... such as in traumatic bleeding secondary to gunshot wounds). Thrombin and fibrin glue are used surgically to treat bleeding and ...

*Mister E

Death sent Tim back to his own time, but did not help Mister E, so he had to go back in time one step at a time. Mister E was ... In the New 52, E has cast an unknown spell that caused his eyes to bleed out. He appears as an enemy of Constantine. ... The Brigade won the fight and Pyotr told them they could avert the tragedy he caused if they took him back in time to the 17th ... On his walk back from the end of time E encountered Pyotr Konstantin, who tagged along with him back to the present day. Mister ...
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BioAssay record AID 698773 submitted by ChEMBL: Antithrombotic activity in Sprague-Dawley rat arteriovenous shunt model assessed as reduction of thrombus dry weight at 30 mg/kg, po qd for 5 consecutive days.
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Bleeding disorders can be subdivided into three categories, including: Primary hemostasis disordersSecondary hemostasis disordersFibrinolysis disorders
Bleeding disorders can be subdivided into three categories, including: Primary hemostasis disordersSecondary hemostasis disordersFibrinolysis disorders
... Platelets have been mostly thought of as a fragment of a cell that stops bleeding and not much else. They can, also
BACKGROUND AND PURPOSE: We aimed to examine perfusion changes between 3 and 6 and 6 and 24 hours after stroke onset and their impact on tissue outcome. METHODS: Acute ischemic stroke patients underwent perfusion magnetic resonance imaging at 3, 6, and 24 hours after stroke onset and follow-up fluid-attenuated inversion recovery at 1 month to assess tissue fate. Mean transit time prolongation maps (MTTp=MTT-[median MTT of contralateral hemisphere]) were obtained at 3 (MTTp3 h), 6 (MTTp6 h), and 24 hours (MTTp24 h). Perfusion changes between 3 and 6 hours (ΔMTTp3_6) and 6 and 24 hours (ΔMTTp6_24) were calculated. A 2-step analysis was performed to evaluate the impact of ΔMTTp3_6 and ΔMTTp6_24 on tissue fate. First, a voxel-based multivariable logistic regression was performed for each individual patient with MTTp3 h, ΔMTTp3_6, and ΔMTT6_24 as independent variables and tissue fate as outcome. Second, Wilcoxon signed-rank tests on logistic regression coefficients were performed across patients ...
Note the typography of the following terms, which are found in descriptions of platelet hemostasis (use parenthetical abbreviated terms in accordance with , Abbreviations, Clinical, Technical, and Other Common Terms): See also , Blood Groups, Platelet Antigens, and Granulocyte Antigens, Platelet-Specific Antigens. |
Note the typography of the following terms, which are found in descriptions of platelet hemostasis (use parenthetical abbreviated terms in accordance with , Abbreviations, Clinical, Technical, and Other Common Terms): See also , Blood Groups, Platelet Antigens, and Granulocyte Antigens, Platelet-Specific Antigens. |
OKennedy, N., Crosbie, L., van Lieshout M., Broom J.L.. Webb D. and Duttaroy, A.K. (2006) Antiplatelet activity of tomato extract. Part I: Effects on platelet function in vitro and ex vivo - a time course cannulation study in healthy humans, Am. J. Clin Nutr 84:570-579 ...
Pathania YS, et al. Acral hemorrhagic blisters induced by reviparin. International Journal of Dermatology 58: 1329-1330, No. 11, Nov 2019. Available from: URL: http://doi.org/10.1111/ijd.14406 - IndiaCrossRefGoogle Scholar ...
We describe the first comparison of the effects of antagonists of different integrins on the arterial response to injury. These data indicate that continuous infusions of antagonists of either αIIbβ3 or αvβ3, started before and continued for 2 weeks after porcine PTCA, significantly reduce neointima formation at 28 days. αIIbβ3 inhibitors had marked effects on platelet aggregation and thrombus formation 6 hours after PTCA, whereas a selective αvβ3 inhibitor showed no effect. Equally, the αvβ3 inhibitors were able to inhibit VSMC adhesion, a property not shared by the selective αIIbβ3 inhibitor, although final reductions in neointima were comparable between the 3 treatment groups.. Both αIIbβ3 inhibition and combined αIIbβ3/αvβ3 inhibition induced rapid inhibition of ex vivo platelet aggregation, translating into concomitant reductions in adherent thrombus. Measurement of ex vivo platelet aggregation may overestimate the degree of platelet inhibition, and the relevance of this ...
There is evidence from recent studies that VEGF is stored in human megakaryocytes and is released from platelets on stimulation with thrombin.14 15 These studies were performed under in vitro conditions in the absence of important determinants of in vivo clotting such as the vessel wall, blood flow, and clotting proteases. Thus, it is uncertain if their in vitro observations are of relevance for the in vivo circumstances. The technique applied in our study covers many mechanisms relevant for hemostatic plug formation in vivo. It is performed directly on human subjects and takes into account the interaction between blood cells, endothelium, and various plasma proteins under physiological flow conditions. Thus, we believe that the experimental approach applied in this study is appropriate for investigating the mechanisms important for plug formation under conditions close to the in vivo circumstances.. The principal finding of our study was that much higher concentrations of VEGF are detectable in ...
In the nanoscale assembly-based design of antithrombotic agents, poly-alpha,beta-DL-aspartyl-L-arginine (MW: 20 741) was prepared. from the thermal polycondensation of DL-aspartic acid and the amidation of polysuccimide with L-arginine. In the pH environments corresponding to the stomach (pH 1.2), intestinal tract (pH 7.6), blood and tissue fluids (pH 7.4) 4.8 x 10(4,2,-4,-6,-8) nM of poly-alpha,beta-DL-aspartyl-L-arginine assembled to form diverse nano-species. The sizes of the smallest nanoparticle, nanobell and nanomango were less than 100 nm. At the oral doses of 0.72, 1.44 and 2.89 mu mol kg(-1), poly-alpha,beta-DL-aspartyl-L-arginine dose-dependently inhibited the ex vivo platelet aggregation and the in vivo thrombosis of the treated rats. By assembling to form diverse nano-species, the absorption of oral poly-alpha,beta-DL-aspartyl-L-arginine in the stomach and intestinal tract could be assisted. ...
Ehlers-Danlos syndrome with Platelet Dysfunction from Fibronectin Abnormality information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Haemostatic effect of N8-GP when used for treatment of bleeding episodes and assessed as: Excellent, Good, Moderate, or None [ Time Frame: For the main phase (from 0-26 weeks of treatment) and the extension phase of the trial (from 26 weeks to the last patient has completed the trial ...
Haemostatic effect of N8-GP when used for treatment of bleeding episodes and assessed as: Excellent, Good, Moderate, or None [ Time Frame: For the main phase (from 0-26 weeks of treatment) and the extension phase of the trial (from 26 weeks to the last patient has completed the trial ...
Recently, several von Willebrand factor gene mutations resulting in type IIA von Willebrands disease have been reported. We examined 8 patients from Sweden and Denmark with this phenotype and found two new candidate mutations and a hitherto unknown amino acid polymorphism. One patient had a de novo occurring mutation resulting in substitution of glycine for arginine 834. Previous reports have demonstrated conversion of arginine 834 to tryptophan or glutamine in IIA patients. A 2nd patient had a G(4825)--|A transition, substituting arginine for glycine 846. The transition produces a sequence congruent with that of the pseudogene but several lines of evidence indicate that a sequencing error due to influence by the latter could be excluded. The remaining 6 patients had one of the earlier described substitution mutations: Ser743--|Leu and Ile865--|Thr. In addition, two sequence variations not linked to the phenotype were found, namely Tyr821--|Cys and Val802--|Leu.
Objective: In order to correct the primary von Willebrand factor (VWF) defect and avoid supra-physiologic plasma levels of factor VIII, a pure VWF concentrate almost devoid of FVIII was developed and used in France since 1989. Methods: The pharmacokinetic (PK) profile of the most recent version of this concentrate (Wilfactin®; LFB, Les Ulis, France), treated with three virus-inactivation/removal methods (solvent/detergent, 35 nm filtration, dry heat treatment), was investigated in 25 patients. Seventeen patients with various types of clinically severe von Willebrand disease (VWD) were included in a crossover, randomized trial carried out in five European centers and comparing Wilfactin® with concentrates containing both FVIII and VWF (FVIII/VWF). Eight type 3 VWD patients were included in another trial carried out in six French centers comparing Wilfactin® with its previous version (Facteur Willebrand-LFB®; LFB) that adopted one virus-inactivation method only. Results: For both the ...
Von Willebrands disease, a common bleeding disorder affecting males and females equally, is usually inherited as a dominant trait.
Prediction of major adverse cardiovascular events (MACEs) may offer great benefits for patients with coronary artery disease (CAD). Von Willebrand factor (vWF) is stored in endothelial cells and released into blood plasma upon vascular dysfunction. This meta-analysis was performed to evaluate the prognostic value of plasma vWF levels in CAD patients with MACEs. A total of 15 studies were included in this meta-analysis through the search in PubMed, Embase and CNKI. Data were collected from 960 patients who had MACEs after CAD and 3224 controls nested without the adverse events. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random-effects model. The plasma vWF levels examined at 24 h and 48 h after admission were significantly higher in CAD patients with MACEs than those without. The pooled SMD among the MACEs group and the non-MACEs group was 0.55 (95% CI = 0.30-0.80, P | 0.0001) and 0.70 (95% CI = 0.27-1.13, P = 0.001), respectively. However, no
The drug desmopressin (1-deamine-8-D-arginine vasopressin [DDAVP]) has become a mainstay of therapy for most patients with mild von Willebrand disease.
Thromboregulation is the series of mechanisms in how a primary clot is regulated. These mechanisms include, competitive inhibition or negative feedback. It includes primary hemostasis, which is the process of how blood platelets adhere to the endothelium of an injured blood vessel. Platelet aggregation is fundamental to repair vascular damage and the initiation of the blood thrombus formation. The elimination of clots is also part of thromboregulation. Failure in platelet clot regulation may cause hemorrhage or thrombosis. Substances called thromboregulators control every part of these events. One primary function of thromboregulation is the control of primary hemostasis, which is the platelet aggregation process. Some thromboregulators enhance platelet aggregation and some others inhibit the process. Platelet aggregation plays a critical role in the genesis of a resulting thrombus. Adhesion should remain local, but platelet aggregation must grow exponentially to form a platelet thrombus and ...
Dosing of mice with clopidogrel (50 mg/kg) completely inhibited ADP-induced ex vivo platelet aggregation and signaling (cAMP) and blocked all of the surface P2Y12 receptors on resting platelets. It is interesting to note that the same high dose of clopidogrel (50 mg/kg) prevented vascular occlusion but did not achieve the thrombotic profile associated with P2Y12 deficiency, whereas the direct-acting inhibitor elinogrel did recapitulate the profile of P2Y12(−/−) mice. Addition of elinogrel (1 mg/kg i.v.) to this clopidogrel regimen (50 mg/kg, 3 days) completely blocked the residual thrombosis, confirming that this process was mediated by P2Y12 receptors. On the basis of this data, we hypothesized that residual thrombosis observed in clopidogrel-treated mice might be due to an unblocked (intracellular) pool of P2Y12 exposed on the platelet surface after platelet activation in vivo. In this study, we demonstrated that an inducible pool of P2Y12 receptors exists in human and mouse platelets and ...
Most patients with vWD have mild disease that may go undiagnosed until trauma or surgery occurs. Trauma or surgery may result in life-threatening bleeding in severely affected individuals.
BioAssay record AID 444449 submitted by ChEMBL: Anticoagulant activity against Sprague-Dawley rat arterial thrombosis model induced by topical application of Fecl2.
Id like to go under the assumption that most of you know what Von Willebrands Disease is, but I realize that I wasnt very educated about it until recently and some of you reading this might not have VWD. VWD is a bleeding disorder with 3 types caused by a lack of the Von Willebrand Factor in your blood. The factor helps clot your blood and also carries factor 8 through your blood. In type 1, you simply dont have enough of it. In type 2, you also dont have enough of it, but there are several sub-types of type 2. I would try to further explain type 2, but it is highly complicated and given that I have type 1, I dont fully understand it. Type 3 is the most severe type of VWD, in this case, you do not have any of the Von Willebrand factor circulating through your blood. It is very rare to have type 3 because both of your parents must have VWD, of any type, in order for you to have type 3. And even if both of your parents have VWD, it doesnt mean youll end up with type 3 or VWD at all ...
s body exhumed in order to prove her case. We were told that my sister had died of coronary artery thrombosis, but she didnt have a history of heart disease, she said this week. There was no trace of alcohol or barbiturates in her system, but there was this brown cereal-type substance which was never identified. I believe she was killed because someone wanted to silence her. But who? Maxine admits that she has privately confronted the man she suspects of being responsible for her sisters death. ...
Platelet-fibrin thrombi in the lumen of atherostenotic carotid arteries may underlie transient ischemic attacks and cerebral infarction. For this reason, we investigated the antiplatelet and antithrombotic effects of a novel and potent platelet fibrinogen receptor (glycoprotein IIb/IIIa) antagonist (SK&F 106760).. The effects of 0.1-3.0 mg/kg i.v. SK&F 106760 on platelet aggregation were examined ex vivo in canine platelet-rich plasma (n = 20). In addition, the antithrombotic effects of SK&F 106760 were compared with those of aspirin in an acute canine model of extracranial carotid artery thrombosis with high-grade stenosis. Sham-operated (n = 4), vehicle-treated (n = 6), SK&F 106760-treated (n = 8), aspirin-treated (n = 9), and SK&F 106760+aspirin-treated (n = 5) dogs were examined.. The intravenous administration of SK&F 106760 caused a dose-related inhibition of ex vivo platelet aggregation. In the carotid artery thrombosis model, an occlusive thrombus formed at stenotic sites in the region ...
Background-Selective inhibitors of cyclooxygenase-2 (COX-2) increase the risk of myocardial infarction and thrombotic events, but the responsible mechanisms are not fully understood. Methods and Results-We found that ferric chloride-induced arterial thrombus formation was significantly greater in COX-2 knockout (KO) compared to wild type (WT) mice. Cross-transfusion experiments excluded the likelihood that COX-2KO platelets, despite enhanced aggregation responses to collagen and thrombin, are responsible for increased arterial thrombus formation in COX-2KO mice. Importantly, we observed that COX-2 deletion decreased prostacyclin (PGI2) synthase and production, proliferator-activated receptor (PPAR)δ and sirtuin-1 (SIRT1) expression, with consequent increased upregulation of tissue factor (TF), the primary initiator of blood coagulation. Treatment of WT mice with a PGI2 receptor (IP) antagonist or a PPARδ antagonist, which predisposes to arterial thombosis, decreased SIRT1 expression and ...
vWf is one of several endothelium derived haemostatic mediators, with key roles in platelet aggregation and stabilisation of circulating clotting factors.17 Large quantities of vWf are stored in the Weibel-Palade bodies of endothelial cells and can be mobilised rapidly after endothelial cell activation18 to result in transient increases of plasma vWf.10 In experimental models at least, endothelial dysfunction has been shown to promote thrombosis, vasospasm, and vessel occlusion.19 One recent study found increased concentrations of immunoreactive vWf in the endothelium over the endocardial cells lining the surface of human left atrial appendage in patients with cardiac disease and further found thrombus formation over sites exhibiting impaired endothelial function.20. Thus, persistently increased concentrations of vWf and endothelial damage and dysfunction pose a real risk to thrombosis. Indeed, our recent cross sectional study suggests a relation between vWf and risk stratification for stroke ...
We studied a broad spectrum of platelet function parameters. Together with a low analytical variability for the various tests, a homogenous group of study subjects, and strictly standardized study conditions, these parameters would give a high sensitivity for detecting effects of infused epinephrine on platelet function.. Platelet count increased progressively with increasing arterial epinephrine in both EDTA- and ACD-anticoagulated blood, and the weight of circulating platelets increased by 29%, indicating recruitment of platelets into the circulation. Platelet size increased significantly in EDTA and decreased in ACD. The difference between EDTA and ACD was significant for both platelet count and size, suggesting that epinephrine not only recruits platelets into the circulation but also induces some microaggregation in vivo or adhesion ex vivo. Platelet aggregation in vitro induced by epinephrine decreased after infusion of epinephrine compared with saline but did not change when stimulated ...
2018 Elsevier Inc. All rights reserved. Transfusion medicine physicians and laboratory scientists are confronted daily with hemostasis and thrombosis-related concerns as they select and administer blood components, coagulation factor concentrates, anticoagulants, and agents to manage anticoagulant therapy. This chapter provides an introduction and overview of hemostasis. Primary hemostasis focuses on platelet function and interactions with the vasculature, endothelium, and the coagulation mechanism. Secondary hemostasis focuses on the coagulation cascade and is subdivided into the extrinsic, intrinsic, and common enzymatic pathways. Coagulation also includes control systems such as protein C, protein S, and antithrombin, and fibrinolysis. Depending on the defect, hemostasis disorders may be congenital or acquired, resulting in hemorrhage or thrombosis. The questions in this chapter will explore normal hemostasis, disorders of hemostasis, and the laboratory assays that predict, identify, and ...
It has been demonstrated that the umbilical cord matrix, represented by the Whartons Jelly (WJ), contains a great number of mesenchymal stem cells (MSCs), characterized by the expression of specific MSCs markers, shared by both human and animal models. The easy access to massive WJ amount makes it an attractive source of MSCs for cell-based therapies. However, as in other stem cell models, a deeper investigation of WJ-derived MSCs (WJ-MSCs) biological properties, probably modulated by their prolonged expansion and fast growth abilities, is required before their use in clinical settings. In this context, in order to analyze specific gene expression modifications occurring in WJ-MSCs, along with their culture prolongation, we investigated the transcriptomic profiles of WJ-MSCs after 4 and 12 passages of in vitro expansion by microarray analysis. Hierarchical clustering analysis of the data set originated from a total of 6 experiments revealed that in vitro expansion of WJ-MSCs up to 12 passages promote
Question - Trying to conceive, have platelet dysfunction in blood, getting heavy periods. Will it be transferred to baby?. Ask a Doctor about Fertility monitor, Ask an OBGYN, Maternal and Fetal Medicine
T cells are isolated from a patients blood and retrained, or "primed," to recognise tumour cells. They are then injected back into the patients bloodstream where they can now hunt and fight cancer.. There was some evidence that platelets might make cancer worse. For example, patients who have excessive clotting related to their cancer almost always have a worse prognosis, according to Li.. "Over the years, it has become appreciated that platelets are doing more than just clotting," says Li.. The first clue that cancer-fighting T cells might be suppressed by the bodys own clotting system came when the researchers gave melanoma to mice with genetically defective platelets.. Melanoma tumours grew much more slowly and primed T cells were much more active than in mice with normal platelets.. Next, the team isolated platelets and T cells from blood drawn from humans and mice.. In both cases, platelets with activated clotting activity suppressed T cell response.. It then used mass spectrometry to ...
Principal Investigator:TANI Kazuhiro, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Thoracic surgery
Arterial thrombosis is much less common than venous thrombosis, although it poses similar risks. The veins are responsible for taking blood and oxygen to different sections of the body. The blood is normally subject to higher pressure when it is travelling in the veins and may be moving more quickly. It is therefore less likely to clot in the arteries. Whereas venous thromboses normally lead to swelling and fluid congestion in an area, arterial thrombosis can lead to body tissue becoming starved of blood and oxygen. This can eventually lead to necrosis of the tissue. A thrombosis or embolism in the coronary artery can cause a heart attack. If blood supply to the brain is disrupted, the patient may suffer a stroke. ...
Dear Dr. Donohue: When I was 15, I had surgery and had blood tests. My doctor said there was a problem. He discovered I have a bleeding problem called von Willebrands disease. I am now 16, and even
... are conditions that prevent clotting elements in the blood, called platelets, from working as they should. Platelets help the blood clot. Congenital means present from birth.
Acetylsalicylic acid preparations specifically intended for use as antithrombotic agents are classified in this group. This exception from the basic principle of only one code for each route of administration is made because of the extensive use of acetylsalicylic acid both as an antithrombotic agent and as an analgesic. Whether an acetylsalicylic acid product should be classified in this group or in N02BA, should be decided at the national level based on the main indication of the product ...
Acetylsalicylic acid preparations specifically intended for use as antithrombotic agents are classified in this group. This exception from the basic principle of only one code for each route of administration is made because of the extensive use of acetylsalicylic acid both as an antithrombotic agent and as an analgesic. Whether an acetylsalicylic acid product should be classified in this group or in N02BA, should be decided at the national level based on the main indication of the product ...
Diagnostica Stago, Inc., (DSI) is an industry leader in the science of hemostasis and thrombosis. Stago provides the total commitment of global resources and responsiveness, coupled with cutting edge technology and reliability. DSI is dedicated to continually developing and providing the very best hemostasis products, technical support, and services. ...
A] - M. L. VAN MONTFOORT ET AL, "Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model", THROMBOSIS AND HAEMOSTASIS, DE, (20130808), vol. 110, no. 5, doi:10.1160/TH13-05-0429, ISSN 0340-6245, pages 1065 - 1073, XP055293624 [A] 1-48 * figure all; example all; table all ...
Acquired von Willebrand disease is a rare bleeding disorder that might be caused by other medical problems or medicines. It prevents blood from clotting properly. It is rarer than the inherited form of von Willebrand disease. Medical problems that might cause acquired von Willebrand disease include: Lymph disorders...
Von Willebrand disease (vWD) is a common, inherited, genetically and clinically heterogeneous hemorrhagic disorder caused by a deficiency or dysfunction of the protein termed von Willebrand factor (vWF). Consequently, defective vWF interaction between platelets and the vessel wall impairs primary hemostasis.
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TY - JOUR. T1 - Inherited Disorders of Hemostasis in Dogs and Cats. AU - Barr, James W.. AU - McMichael, Maureen. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Inherited disorders of hemostasis encompass abnormalities in primary hemostasis, coagulation, and fibrinolysis resulting from genetic mutations. There is significant variation in the phenotype expressed ranging from life limiting to the absence of overt clinical signs. Von Willebrand disease is the most common primary hemostatic disorder in dogs, and hemophilia A is the most common coagulation factor disorder. The diagnosis of inherited bleeding disorders is made by functional and/or quantitative evaluation. Genetic testing has added to the knowledge base, allowing prevention through targeted breeding. Avoidance of trauma and injury is paramount in the prevention of bleeding in animals diagnosed with inherited hemostatic disorders. Current therapeutic options include platelet transfusions, broad replacement of coagulation factors (e.g., plasma), ...
This study investigated the safety, tolerability and efficacy of lansoprazole [Takepron; Takeda] in patients with gastric ulcer, duodenal ulcer, acute stress
Journal of stroke and cerebrovascular diseases : official publication of the National Stroke Association 10(5), 227-230, 2001-09-01 ...
Im a nursing student, but Im also a patient. I have Von Willebrands disease and am scheduled for a hysterectomy next Wednesday. During my pre-op admission stuff, the RN told me that they use an
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Introduction: Von Willebrand disease is the most prevalent coagulation inherited disease, affecting about 1.0% of the population. There are several classifications of the disease having it types: Type 1: One of the symptoms to clinical eyes are bruises, skin squamoses with only slight touches. Objective: The objective of the study was to make a brief discussion through literary review and to show that von Willebrand disease type 1 is not life - threatening. Methods: Experimental and clinical studies were included (case reports, retrospective, prospective and randomized trials) with qualitative and / or quantitative analysis. The words were included "Von Willebrand disease", "Diagnosis", "Optimization of care". A total of 40 articles were found involving Von Willebrand disease. A total of 15 articles were evaluated in full, and 10 were included and discussed in this study. Conclusion: Anamnesis and the detailed clinical examination as well as the request for complementary examinations allow the ...
BACKGROUND AND OBJECTIVES: Unlike patients with hemophilia, those with von Willebrands disease (VWD) have a mild to moderate bleeding tendency requiring a lower rate of transfusion: moreover, the use of blood products in most Italian patients with VWD was greatly reduced following the introduction of desmopressin in 1977. The main objective of this study was to compare the prevalence and outcome of hepatitis C virus (HCV) infection in multi-transfused patients with VWD and in those with hemophilia A or B. DESIGN AND METHODS: In a large cohort of 356 patients with VWD (41% type 1, 53% type 2 and 6% type 3) and 340 with hemophilia A (85%) or B (15%), all of whom were negative for human immunodeficiency virus (HIV) serum HCV markers, liver function tests and abdominal ultrasound were performed every 6 months for 6 years. RESULTS: VWD patients were less often transfused with any type of blood products than were hemophiliacs (40% versus 96%) and were, therefore, less frequently infected with HCV ...
Dronedarone has been associated with a reduced number of first hospitalisation due to acute coronary syndromes. Whether this is only due to the reduction in ventricular heart rate and blood pressure or whether other effects of dronedarone may be involved is currently elusive. This study was designed to investigate the role of dronedarone in arterial thrombus formation. C57Bl/6 mice were treated with dronedarone and arterial thrombosis was investigated using a mouse photochemical injury model. Dronedarone inhibited carotid artery thrombus formation in vivo (P , 0.05). Thrombin- and collagen-induced platelet aggregation was impaired in dronedarone-treated mice (P , 0.05), and expression of plasminogen activator inhibitor-1 (PAI1), an inhibitor of the fibrinolytic system, was reduced in the arterial wall (P , 0.05). In contrast, the level of tissue factor (TF), the main trigger of the coagulation cascade, and that of its physiological inhibitor, TF pathway inhibitor, did not differ. Similarly, ...
The results of the present study demonstrate that ex vivo platelet aggregation in response to ADP and thrombin receptor-activating peptide is not inhibited in patients with CAD by acute or chronic consumption of tea, despite adequate absorption of tea flavonoids, as evidenced by increased total plasma catechin levels. These findings suggest that inhibition of platelet aggregation by tea flavonoids is unlikely to explain the apparent inverse association between tea consumption and atherosclerotic cardiovascular events.. Previous studies of inhibition of platelet aggregation in humans by use of flavonoid-containing foodstuffs have yielded conflicting data. In vitro studies have consistently shown that flavonoid-rich foods, such as red wine, and flavonoid extracts inhibit platelet aggregation11 ; the concentrations tested, however, have generally been higher than those that can be attained in vivo with nutritional supplements.35 Nevertheless, several recent reports have suggested that increased ...
Although referred to as a single disease, von Willebrand disease (VWD) is in fact a family of bleeding disorders caused by an abnormality of the von Willebrand factor (VWF). von Willebrand disease is the most common hereditary bleeding disorder.
Type 3 von Willebrand Disease: A subtype of von Willebrand disease that results from a total or near total deficiency of VON WILLEBRAND FACTOR.
As mentioned in a previous post, I suffer from Von Willebrand disease.. When I was younger, I used to get awful nose bleeds- I mean 20 minutes to a half an hour long. Finally, one day when I was about five or six, I blew my nose during an episode and a blood clot the size of a half dollar came out of my little nose at the time- so my mom called the doctor.. The doctor referred me to a specialist who could figure out what was wrong with me. My mom was worried I was suffering from hemophilia- which we later found out I thankfully wasnt.. When we found out I have Von Willebrand disease, I was too young to understand all of the technical terms. My mom told me my blood needed paper and glue to come together, stick and make a clot, but I was "missing the glue." To this day, its very complicated to understand any other way.. Since we discovered my disease, I was prescribed a nose spray to use during a bloody nose episode. This spray would make the bleeding clot and stop much quicker.. As the years ...
When people have von Willebrand disease, their blood doesnt clot properly. Cuts and wounds cant scab over as well and they might bleed longer than normal. Find out more about von Willebrand disease in this article for teens.
article{b6d47b4f-b03e-4cac-a96b-e95bc67ace18, abstract = {,p,Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Prophylaxis of surgical bleeding in patients with VWD requires consideration of the individual situation, including the type of procedure and the bleeding rate, before decisions about treatment type, dose, duration and adjunctive therapy with antifibrinolytics or antithrombotic prophylaxis can be made. Although desmopressin (DDAVP)-stimulated release of endogenous VWD is an effective treatment strategy in many patients, plasma concentrates containing VWF are the preferred option for most patients undergoing surgical procedures. Recommendations for the management of surgery in patients with VWD are summarised, including the ...
In the determination of parsley (Petroselinum crispum, Apiaceae) used in In Morocco, used to treat cardiovascular diseases such as arterial hypertension, found that The oral administration of CAE (3g/kg) inhibited significantly (p,0.001) platelet aggregation ex vivo and prolonged bleeding time (p,0.001) without changes in the platelet amount. The prolongation of bleeding time by CAE may be attributed to the observed inhibition of platelet aggregation. These effects could be related in part to the polyphenolic compounds present in the extract. These results support the hypothesis that the dietary intake of parsley may be benefit in the normalization of platelet hyperactivation, in the nutritional prevention of cardiovascular diseases and are potentially interesting in the development of new prevention strategies, according to "Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats" by Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Legrand C, Lafeve ...
While the heterozygous Q43P β1-tubulin carriers have a reduced function, the β1-tubulin-deficient mice present with only minor abnormalities in platelet hemostatic functions. Besides the fact that human platelets are more easy to handle and study in detail than mouse platelets, this can probably be explained by the fact that the loss of β1-tubulin expression in mouse platelets was overcome by overexpression of the other platelet β-tubulin variants,7 while the Q43P carrier platelets not only show reduced β1-tubulin but also total β-tubulin protein levels. In addition, incorporation of GFP-tagged Q43P β1-tubulin into wild-type tubulin structures seems to be inefficient and delocalized.. Due to the platelet dysfunction phenotype, the Q43P β1-tubulin variant could not only be conceived as a genetic risk factor for the development of thrombocytopenia but also as a protective genetic factor against cardiovascular disease. Indeed, a case-control study showed that the prevalence of Q43P ...
von Willebrand disease is a relatively mild bleeding disorder, except in the occasional patient who is homozygous for the defect and who has severe bleeding often indistinguishable from classic hemoph... more
Researchers Develop ELISA Assay to Rapidly Diagnose Variant von Willebrand Disease - From the Blood Journals, News, Written in Blood - ASH Clinical News
Von Willebrand Disease Diagnostics (costs for program #145001) ✔ Academic Hospital Neuperlach ✔ Department of Hematology and Oncology ✔ BookingHealth.com
Von Willebrand Disease Diagnostics (costs for program #133747) ✔ University Hospital Giessen UKGM ✔ Department of Oncology, Hematology, Palliative and Abdominal Medicine ✔ BookingHealth.com
BULGULAR: Tan s ras nda, 17/20 hasta anormal trombosit agregasyon sonu lar na sahip idi; sekizinde (%40) hipoaktivite, alt s nda (%30) hiperaktivite ve nde (%15) miks hipo- ve hiperaktivite saptand . Ortalama 19 ay (min: 5 ay-maks: 35 ay) imatinib mesilat kullan m sonras t m hastalarda trombosit agregasyon testleri tekrarland . Tedavi sonras , 18/20 (%90) hasta anormal laboratuvar sonu lar na sahip idi; 12 si (%60) hipoaktif trombositler, d rd (%20) miks hipo- ve hiperaktif trombositler ve ikisi (%10) hiperaktif trombositlere sahip idi. Ba lang ta hipoaktivitesi olan sekiz hastan n hipoaktif kal r iken ikisi miks bir g r nt geli tirdi, ikisi hiperaktif oldu ve biri normalize oldu. Ba lang ta hiperaktivitesi olan alt hastan n d rd hipoaktif oldu ve ikisi miks patern geli tirdi. Ba lang ta hipo- ve hiperaktivitesi olan hastan n tamam hipoaktif oldu. Son olarak, ba lang ta normal trombositleri olan hastan n ikisi hipoaktif olur iken biri normal kald . Ristosetin ile ind klenen trombosit ...
Any medical information provided by this site is not a replacement for medical diagnosis, treatment, or professional medical advice. It should not be used to treat or diagnose any medical condition. Always seek professional medical consultation by a licensed physician for diagnosis and treatment of any and all medical conditions - please, do not ignore your doctors medical advice based on information written by the author or commenters of this site. Please do not ask me for medical advice, but instead contact a healthcare provider in your area. Anything written about office/hospital situations/events are fictional examples to get a point across. No patient is/will ever be a specific patient (unless given written permission), but a fictional one. To know more about how I handle medical information about patients please link here. Unless, I am praising a colleague, even those will be fictional. Any similarities to you or people you know is purely coincidental. My husband and I, and our dogs are ...
Any medical information provided by this site is not a replacement for medical diagnosis, treatment, or professional medical advice. It should not be used to treat or diagnose any medical condition. Always seek professional medical consultation by a licensed physician for diagnosis and treatment of any and all medical conditions - please, do not ignore your doctors medical advice based on information written by the author or commenters of this site. Please do not ask me for medical advice, but instead contact a healthcare provider in your area. Anything written about office/hospital situations/events are fictional examples to get a point across. No patient is/will ever be a specific patient (unless given written permission), but a fictional one. To know more about how I handle medical information about patients please link here. Unless, I am praising a colleague, even those will be fictional. Any similarities to you or people you know is purely coincidental. My husband and I, and our dogs are ...
Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.s profile, publications, research topics, and co-authors
China Jiuhong Disposable Endoscopic Rotatable Hemostasis Clip, Find details about China Quickclip, Hemostasis Clip from Jiuhong Disposable Endoscopic Rotatable Hemostasis Clip - Changzhou JIUHONG Medical Instrument Co., Ltd.
Diagnostica Stago has announced today its Global Haemostasis Solution, a UK based haemostasis hotline comprising of application support, after sales care and training services. The company, which is dedicated to the field of haemostasis, has designed the solution to ensure that customers are provided with reliable, efficient instruments and reagents, all backed up by a dedicated support team.
Acticor Biotech Summary Acticor Biotech is a biopharmaceutical company developing an antithrombotic agent for the treatment of the acute phase of ischemic…
TY - JOUR. T1 - Platelets and Factor VIII in von Willebrands Disease. AU - Green, D.. AU - Potter, E. V.. PY - 1977/6/9. Y1 - 1977/6/9. N2 - To the Editor: In his excellent review, Jaffe1 asks, "What happens to the factor VIII antigen content of the two platelet pools when patients with von Willebrands disease of severe degree are given transfusions of plasma factor VIII?" We have performed in vitro and in vivo studies to answer his question. Immunofluorescent staining of platelets of patients with von Willebrands disease incubated with normal plasma indicated that factor VIII antigen did not become platelet bound unless aggregation was induced by ristocetin.2 Likewise, platelets obtained from such patients after cryoprecipitate infusion showed minimal or no staining before but intense staining. No extract is available for articles shorter than 400 words.. AB - To the Editor: In his excellent review, Jaffe1 asks, "What happens to the factor VIII antigen content of the two platelet pools when ...
Looking for online definition of von Willebrand disease in the Medical Dictionary? von Willebrand disease explanation free. What is von Willebrand disease? Meaning of von Willebrand disease medical term. What does von Willebrand disease mean?
Patients with acquired von Willebrand disease may present with severe bleeding, which is usually difficult to manage. Adequate haemostasis in acquired von Willebrand disease may be achieved with the infusion of factor VIII/von Willebrand factor concentrates or with the administration of desmopressin. We report a case of acquired von Willebrand disease with severe postoperative bleeding, responding poorly to classical von Willebrand factor replacement therapy but successfully treated with high-dose intravenous gammaglobulins. This new treatment mode of acquired von Willebrand disease is discussed in the light of a critical analysis of the literature.. ...
Thomas F. Slaughter, Elinor A. Mody, H. Newland Oldham, J. G. Reves, Christopher M. OConnor, Judith K. Parker, Charles S. Greenberg; Management of a Patient with Type IIC von Willebrands Disease during Coronary Artery Bypass Graft Surgery. Anesthesiology 1993;78(1):195-197. Download citation file:. ...
TY - JOUR. T1 - Expression and functional characterization of an abnormal platelet membrane glycoprotein Ibα (Met239 → Val) reported in patients with platelet-type yon Willebrand Disease. AU - Moriki, Takanori. AU - Murata, Mitsuru. AU - Kitaguchi, Tetsuya. AU - Anbo, Hironobu. AU - Handa, Makoto. AU - Watanabe, Kiyoaki. AU - Takahashi, Hoyu. AU - Ikeda, Yasuo. PY - 1997/7/15. Y1 - 1997/7/15. N2 - Platelet-type von Willebrand disease (vWD) is a congenital bleeding disorder characterized by heightened ristocetin-induced platelet aggregation caused by abnormally high affinity between the platelet membrane glycoprotein (GP) Ib/IX complex and von Willebrand factor (vWF). Two distinct point mutations, Gly233 to Val and Met239 to Val, have been reported in GPIbα. We have constructed a recombinant GPIbα fragment containing the latter mutation, Met239 to Val (M239V) and characterized the mutant molecule using two methods, ie, interaction between soluble vWF and immobilized M239V and inhibition of ...
von Willebrand factor is a form of carrier protein for factor VIII. In von Willebrand disease, there will be deficiency in von Willebrand factor which lead to functional impairment of the factor VIII. This condition may lead to impairment of the coagulati
Platelet Aggregation Test - The DiaMed Impact R tests platelet function Specializing in Platelet Function testing, bleeding time, platelet count, platelet function analysis. Bleeding time lab test and platelet function analyzer ideal tool for platelet function studies.
Medical research for Von Willebrand disease including cure research, prevention research, diagnostic research, and basic research.
An inherited bleeding disorder caused by a reduction in the amount or function of von Willebrand factor (vWF), which is manifested through abnormal platelet function and prolonged bleeding time. The vWF factor is a blood protein which binds platelets to blood vessels when they are injured. Absence or deficiency of the factor can, therefore, lead to uncontrolled bleeding episodes. In dogs, the most common clinical signs are spontaneous bleeding from the gums or nose, blood in the urine or gastrointestinal tract, or excessive bleeding at the time of surgery.
Effects of Reviparin, a Low-Molecular-Weight Heparin, on Mortality, Reinfarction, and Strokes in Patients With Acute Myocardial Infarction Presenting With ST-Segment Elevation Academic Article ...
Platelet disorders can involve either a decreased number of platelets (thrombocytopenia) or defective platelet function. Functional disorders of platelets can be inherited (rare) or acquired (common).... more
Ten authoritative reviews. Seven are on topics mainly of interest to investigative hematologists. Three are on topics directly relevant to clinical problems: von Willebrands disease (L. W. Hoyer); platelet transfusion (S. Murphy); and heparin therapy (S. Wessler and S. Gitel). Detailed subject index. ...
Because of its high sensitivity and reproducibility, the FeCl3‐induced arterial thrombosis mouse model is widely used to study molecular mechanisms as well as the efficacy of antithrombotic agents
The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the blood in the passageway to detect the platelet mass. The flow and composition change in response to the formation of a platelet mass in the passageway. Devices, articles, and kits for performing the methods are also disclosed.
The normal platelet count for adult males is 150 to 450 billion per liter of blood, notes Mayo Clinic. Platelet counts outside of this range may be indicative of a medical condition or be the result...
The neuter went ok yesterday. There was excessive bleeding, so the doctor was a bit worried about Von Willebrand disease, but the bleeding stopped, so she just wanted me to know to be aware if he needs any other surgeries at some point in the future. When I brought him home last night he was still a bit stoned, but he had no problems gobbling up supper. The nurse said to feed him a bit at a time, so I did. Oak was not impressed by the fact that he only got a wee bit of food, then had to wait! He was also not as tired as I expected him to be. He even wanted to play a bit!(I didnt let him, though) He tried to chew on his incision a couple of times and it started bleeding, sooo....now he has to wear a cone :( Poor little man ...
Researchers report experimental drug Integrelin works better than standard treatment, aspirin, to treat unstable angina, heart disorder; say new drug may especially benefit women and provide clues about differences between sexes in heart disease; COR Therapeutics and Schering-Plough make drug (M)m
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
2016 Switzerland Hemostasis Diagnostics Market: Reagent and Volume Forecasts for 40 Assays, Competitive Strategies, Instrumentation Review, Innovative Technologies, Opportunities for Suppliers Published by VPGMarketResearch.com at researchbeam.com 350 Pages

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He allows them obtain reasonable settlements and, in circumstances that head over to demo, can take time to organize them to ... business negotiated a private settlement for the family members of a plaintiff who died on account of a femoral artery bleed ... Condition legislation establishes the statutory time during which to file a lawsuit. If you suspect there is a circumstance, ... Exclusive servers for faster access in peak times, for you and your visitors ...
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Bleeding time - WikipediaBleeding time - Wikipedia

It involves making a patient bleed then timing how long it takes for them to stop bleeding. The term template bleeding time is ... The time from when the incision is made until all bleeding has stopped is measured and is called the bleeding time. Every 30 ... The test ceases when bleeding ceases. The usual time is about 2-5 minutes. Bleeding time is affected by platelet function, ... The time it takes for the bleeding to stop (i.e. the time it takes for a platelet plug to form) is measured. Cessation of ...
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Bleeding time: MedlinePlus Medical EncyclopediaBleeding time: MedlinePlus Medical Encyclopedia

Bleeding time is a medical test that measures how fast small blood vessels in the skin stop bleeding. ... Bleeding time is a medical test that measures how fast small blood vessels in the skin stop bleeding. ... Bleeding time, ivy - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. Philadelphia ... Blotting paper is touched to the cuts every 30 seconds until the bleeding stops. The provider records the time it takes for the ...
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Northside Hospital
				- Bleeding timeNorthside Hospital - Bleeding time

Bleeding time. Definition Bleeding time is a blood test that looks at how fast small blood vessels in the skin close to stop ... Blotting paper is touched to the cuts every 30 seconds until the bleeding stops. The health care provider records the time it ... Drugs that may increase bleeding times include dextran, nonsteroidal anti-inflammatory drugs (NSAIDs), and salicylates ( ... This test helps diagnose bleeding problems. Normal Results Bleeding normally stops within 1 to 9 minutes. However, values may ...
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Effect of Age on Bleeding Time?Effect of Age on Bleeding Time?

What is , was the age of the person who lived the longest period of time on this planet? ...
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Bleeding Time (Standardized Ivy)Bleeding Time (Standardized Ivy)

Bleeding times are no longer offered at University of Iowa Hospitals and Clinics. The test used to screen for platelet function ...
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Bleeding time test legal definition of bleeding time testBleeding time test legal definition of bleeding time test

What is bleeding time test? Meaning of bleeding time test as a legal term. What does bleeding time test mean in law? ... Definition of bleeding time test in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Bleeding time test legal definition of bleeding time test https://legal-dictionary.thefreedictionary.com/bleeding+time+test ... 14) The bleeding time test is not at all useful to assess oral bleeding after invasive dental procedures.. Is the practice of ...
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Template bleeding time | definition of template bleeding time by Medical dictionaryTemplate bleeding time | definition of template bleeding time by Medical dictionary

What is template bleeding time? Meaning of template bleeding time medical term. What does template bleeding time mean? ... Looking for online definition of template bleeding time in the Medical Dictionary? template bleeding time explanation free. ... Bleeding Time. Synonym/acronym: Mielke bleeding time, Simplate bleeding time, template bleeding time, Surgicutt bleeding time, ... Related to template bleeding time: Mielke bleeding time. template bleeding time. A bedside test to determine the presence of ...
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Ovulating on the patch? Bleeding time on patch... - Birth Control Message Board - HealthBoardsOvulating on the patch? Bleeding time on patch... - Birth Control Message Board - HealthBoards

Ovulating on the patch? Bleeding time on patch... Im on the patch because my OB feels I have low estrogen/progesterone levels ... Re: Ovulating on the patch? Bleeding time on patch... hey.. cant answer about the low estrogen and ovulating, maybe its ... HealthBoards , Family , Birth Control > Ovulating on the patch? Bleeding time on patch... ... All times are GMT -7. The time now is 12:12 AM. ... Light bleeding/spotting on the patch? ep65. Birth Control. 0. ...
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LEADING RESEARCHERS REPORT THAT TP-9201 PREVENTS BLOOD CLOTTING WITHOUT INCREASING BLEEDING TIME - Free Online LibraryLEADING RESEARCHERS REPORT THAT TP-9201 PREVENTS BLOOD CLOTTING WITHOUT INCREASING BLEEDING TIME - Free Online Library

LEADING RESEARCHERS REPORT THAT TP-9201 PREVENTS BLOOD CLOTTING WITHOUT INCREASING BLEEDING TIME by PR Newswire; Business ... The ability to more rapidly open occluded blood vessels to the heart was observed with only a minor effect on bleeding time, a ... APA style: LEADING RESEARCHERS REPORT THAT TP-9201 PREVENTS BLOOD CLOTTING WITHOUT INCREASING BLEEDING TIME. (n.d.) >The Free ... MLA style: "LEADING RESEARCHERS REPORT THAT TP-9201 PREVENTS BLOOD CLOTTING WITHOUT INCREASING BLEEDING TIME." The Free Library ...
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Molecular map of Chromosome 19 including three genes affecting bleeding time: ep, ru , and bmMolecular map of Chromosome 19 including three genes affecting bleeding time: ep, ru , and bm

The brachymorphic ( bm ) gene, in addition to causing skeletal abnormalities, is also associated with prolonged bleeding times ... Molecular map of Chromosome 19 including three genes affecting bleeding time: ep, ru , and bm ... "Molecular map of Chromosome 19 including three genes affecting bleeding time: ep, ru , and bm ." Mammalian Genome 5(6): 356-360 ...
more infohttps://deepblue.lib.umich.edu/handle/2027.42/47011

Does dietary arsenic and mercury affect cutaneous bleeding time and blood lipids in humans? | Springer for Research &...Does dietary arsenic and mercury affect cutaneous bleeding time and blood lipids in humans? | Springer for Research &...

The dietary As load strongly correlated both with bleeding times and changes in bleeding times (r=0.48,p,0.01 andr=0.54,p,0.002 ... Does dietary arsenic and mercury affect cutaneous bleeding time and blood lipids in humans?. ... Selenium seemed to have only a modest effect on bleeding time. Our results suggest that mercury and arsenic from fish may be ... The present study investigated the relationships between dietary intake of these elements and cutaneous bleeding time and blood ...
more infohttps://rd.springer.com/article/10.1007/BF02790074

Correlation between bleeding times and platelet counts in preeclamptic women undergoing cesarean section | Anesthesiology | ASA...Correlation between bleeding times and platelet counts in preeclamptic women undergoing cesarean section | Anesthesiology | ASA...

Correlation between bleeding times and platelet counts in preeclamptic women undergoing cesarean section. Anesthesiology 9 1988 ... J. Ramanathan, B. M. Sibai, T. Vu, D. Chauhan; Correlation between bleeding times and platelet counts in preeclamptic women ... Correlation between bleeding times and platelet counts in preeclamptic women undergoing cesarean section ... Correlation between bleeding times and platelet counts in preeclamptic women undergoing cesarean section ...
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bleeding-time-kitsbleeding-time-kits

... and bleeding tendency of patients. Coagulation time procedure kits and trays are used in medical offices, anticoagulation ... Stop the Bleeding. Denials represent a clear and present financial danger for physician practices. Not only do they have the ... Please only use one option at a time. 1) Build a boolean search string. Ensure that document matches include... ... Procedure Kit/Trays, Coagulation Time. Definition : Prepackaged collections of the devices and supplies (either custom or ...
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Surgicutt Bleeding Time DeviceSurgicutt Bleeding Time Device

Automatic incision-making handheld device for determining bleeding time, i.e., buccal mucosal bleeding time ... Surgicutt Bleeding Time Device. JORGENSEN LABS INC. See My Price Description. * ...
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Normal withdrawal bleed on time - Doctor answersNormal withdrawal bleed on time - Doctor answers

That is the normal time for withdrawal bleeding when you stop a hormone. ... What does it mean when withdrawal bleeding stops after a week. Is it normal? Yes. ... Took Plan B both times, less than 24 hrs. Week later, somewhat heavy bleeding. Period or withdrawal bleed? ... 3 times a day from 30th to 4th july (as told by doctor). please tell me wen will withdrawal bleeding start? ...
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QBT - Quantitative Bleeding Time in Medical & Science by AcronymsAndSlang.comQBT - Quantitative Bleeding Time in Medical & Science by AcronymsAndSlang.com

The Medical & Science Acronym /Abbreviation/Slang QBT means Quantitative Bleeding Time. by AcronymAndSlang.com ... QBT stands for "Quantitative Bleeding Time". Q: A: How to abbreviate "Quantitative Bleeding Time"?. "Quantitative Bleeding Time ... Quantitative Bleeding Time can be abbreviated as QBT. QBT - Quantitative Bleeding Time in Medical & Science by AcronymsAndSlang ... QBT as abbreviation means "Quantitative Bleeding Time". Q: A: What is shorthand of Quantitative Bleeding Time?. The most common ...
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No Time to Bleed (song) - WikipediaNo Time to Bleed (song) - Wikipedia

"No Time to Bleed" - 2:22 "No Time to Bleed (Big Chocolate Remix)" - 4:57 Suicide Silence Alex Lopez - drums Mark Heylmun - lead ... No Time to Bleed - Single by Suicide Silence iTunes SUICIDE SILENCE To Release No Time To Bleed Seven-Inch Single ... "No Time to Bleed" is a song by American deathcore band, Suicide Silence. The song was released as the third and final single ... Blabbermouth Suicide Silence - No Time To Bleed (Single) Century Media. ...
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Subcutaneous desmopressin (DDAVP) shortens the prolonged bleeding time in patients with liver cirrhosis<...Subcutaneous desmopressin (DDAVP) shortens the prolonged bleeding time in patients with liver cirrhosis<...

One hour after DDAVP injection the bleeding time was significantly shortened (p ,0.05). After 4 h, however, the bleeding time ... One hour after DDAVP injection the bleeding time was significantly shortened (p ,0.05). After 4 h, however, the bleeding time ... One hour after DDAVP injection the bleeding time was significantly shortened (p ,0.05). After 4 h, however, the bleeding time ... One hour after DDAVP injection the bleeding time was significantly shortened (p ,0.05). After 4 h, however, the bleeding time ...
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When shall I check my pregnancy test at home I thought I got implantation bleeding dis time ????. | Mom Answers | BabyCenterWhen shall I check my pregnancy test at home I thought I got implantation bleeding dis time ????. | Mom Answers | BabyCenter

When shall I check my pregnancy test at home I thought I got implantation bleeding dis time ????.. ... Now Iam feel it may be implantation bleeding because still I am feeling vomiting sensation and tiredness. Is anyway Iam ...
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The Effects of Arnica Montana on Bleeding Time: A Randomized Clinical Trial | ENCOGNITIVE.COMThe Effects of Arnica Montana on Bleeding Time: A Randomized Clinical Trial | ENCOGNITIVE.COM

The difference between the bleeding time of each subject 30 minutes after treatment (T(30)) and the time of initial bleeding (T ... The length of bleeding from each incision was recorded and the average of these two values was taken as the bleeding time. ... Bleeding time is generally used to detect altered hemostasis, which may prolong the length of bleeding in an individual. In ... The Effects of Arnica Montana on Bleeding Time: A Randomized Clinical Trial. Tagged: *Arnica (Arnica montana) ...
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Bleeding and Coagulation Time     13Bleeding and Coagulation Time 13

جامعة بابل كلية طب الاسنان Bleeding and Coagulation Time 13 ... Bleeding And Coagulation Time. Bleeding means loss of blood from damaged or injured small vessels. The bleeding time is the ... Bleeding Time prolonged in : 1.Hemophilia :Which is a rare hereditary bleeding disorder. Characterized by a deficiency of a ... 4.Aspirin prolonged the bleeding time by 2-3 times in normal persons, so patients should be instructed not to take it one week ...
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Do not ignore post-menopausal bleeding: doctor - Taipei TimesDo not ignore post-menopausal bleeding: doctor - Taipei Times

A doctor has urged women to seek medical help if they experience post-menopausal vaginal bleeding, as it can be a sign of a ... at three to four times a month, unlike menstrual bleeding, which occurs once a month. ... Vaginal bleeding or spotting is not normal in post-menopausal women who have not experienced a period for more than a year, and ... A doctor has urged women to seek medical help if they experience post-menopausal vaginal bleeding, as it can be a sign of a ...
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US Patent for Vitro bleeding time determination Patent (Patent #  5,089,422 issued February 18, 1992) - Justia Patents SearchUS Patent for Vitro bleeding time determination Patent (Patent # 5,089,422 issued February 18, 1992) - Justia Patents Search

The time required before blood stops flowing through the slit is recorded, and is the bleeding time. It is preferred that the ... An apparatus and method for in vitro bleeding time determination. Blood is placed in a tube having a window covered with a clot ... However, this bleeding time is accurate, well controlled, and reproducible, unlike the in vivo bleeding time. ... Currently cardiovascular surgeons use the in vivo bleeding time as a screening test. The in vitro bleeding time can replace ...
more infohttps://patents.justia.com/patent/5089422
  • Schafer A. Hemorrhagic disorders: Approach to the patient with bleeding and thrombosis. (northside.com)
  • SAN DIEGO, Nov. 19 ~PRNewswire~ -- Telios Pharmaceuticals Inc. (NASDAQ: TLIO) announced that its compound, TP-9201, has been shown by independent researchers to prevent blood clotting without increasing bleeding time in animal models of heart attack and thrombosis. (thefreelibrary.com)
  • Until now, experts have believed it was necessary to compromise the control of bleeding to prevent thrombosis," said Michael D. Pierschbacher, Ph.D., senior vice president and scientific director of Telios and a co-founder of the company. (thefreelibrary.com)
  • Prevention of intravascular thrombosis, however, has a narrow therapeutic window, bleeding risk, the incidence of resistance, and unwanted drug interactions, hence the need for anti-thrombotic drugs that deliver more effective prevention of intravascular thrombosis. (org.ng)
  • Her medical history and her family history were negative for bleeding tendency or thrombosis. (tjh.com.tr)
  • The research sought to investigate the effect of Moringaoleifera ethanolic seed extract on Bleeding Time (BT) and Clotting Time (CT), in Wistar albino rats. (org.ng)
  • Drugs that may increase bleeding times include dextran, nonsteroidal anti-inflammatory drugs (NSAIDs), and salicylates (including aspirin). (northside.com)
  • 4.Aspirin prolonged the bleeding time by 2-3 times in normal persons, so patients should be instructed not to take it one week before the test is performed. (edu.iq)
  • Eighty-one women with a physicians' diagnosis of menorrhagia underwent PFA-100 and bleeding time tests to evaluate their effectiveness as screening tools for VWD and platelet dysfunction. (thefreedictionary.com)
  • We carried out a double-blind, placebo-controlled crossover study in ten patients with liver cirrhosis to evaluate whether or not their prolonged bleeding times could be shortened by subcutaneous injections of DDAVP (0.3 μg/kg), a more practical route of administration than intravenous infusions. (elsevier.com)
  • Birth control withdrawal bleeds as experienced by taking oral contraceptives would last up until you take the last sugar or placebo pill. (healthtap.com)
  • There was no bleeding time change after placebo. (elsevier.com)
  • In a preliminary report, women with prolonged bleeding in association with Implanon were randomized to various treatment regimens, among which were doxycycline, 100 mg twice daily for 5 days, or placebo. (blogspot.com)
  • A second test measures the intrinsic pathway and is called the partial thromboplastin time or PTT. (justia.com)
  • My practitioner told me to go ahead and keep the Nuvaring and that if I wanted to regulate my bleeding I could continue to use it. (blogspot.com)
  • An apparatus and method for in vitro bleeding time determination. (justia.com)
  • The brachymorphic ( bm ) gene, in addition to causing skeletal abnormalities, is also associated with prolonged bleeding times. (umich.edu)
  • The aviation industry's bleeding account-books showed more red on Wednesday as Kingfisher Airlines and SpiceJet posted huge losses, but, unlike Jet Airways, which reported losses higher than the year-ago quarter a day earlier, the two other airlines showed contractions in the losses. (hindustantimes.com)
  • A doctor has urged women to seek medical help if they experience post-menopausal vaginal bleeding, as it can be a sign of a serious disorder, citing a case of a Nantou County woman who was diagnosed with endometrial cancer after experiencing the symptom. (taipeitimes.com)
  • Although the Mielke or template bleeding time is believed to offer greater standardization to a fairly subjective procedure, both methods are thought to be of equal sensitivity and reproducibility. (thefreedictionary.com)
  • In 1986 IV TXA was approved by the FDA for use in the prevention of bleeding after dental extraction in hemophiliacs. (epmonthly.com)
  • Withdrawal bleed a few days later will it have an effect on my regular period I'm due this friday normally? (healthtap.com)
  • Selenium seemed to have only a modest effect on bleeding time. (springer.com)
  • 3, 4) This second study evaluates the effectiveness of a treatment for bleeding. (linode.com)
  • The item The effects of low-fat diets rich in arachidonic acid on the composition of plasma fatty acids and bleeding time in Australian Aborigines, Kerin O'Dea and Andrew J. Sinclair represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Australian Institute of Aboriginal and Torres Strait Islander Studies (AIATSIS) . (aiatsis.gov.au)
  • Documentation of notification should be made in the medical record with the name of the HCP notified, time and date of notification, and any orders received. (thefreedictionary.com)
  • The woman, surnamed Wang (王), is about 60 years of age and said she had experienced vaginal bleeding for months, but had stopped menstruating five years ago. (taipeitimes.com)
  • My wife and I have been married 31 years and she has still bled after prolonged or vigorous sex a few times. (ourhealth.com)