Blastomycosis
Blastomyces
Lung Diseases, Fungal
Central Nervous System Fungal Infections
Histoplasmosis
Itraconazole
Coccidioidomycosis
Antifungal Agents
Paracoccidioidomycosis
Blastomycosis acquired occupationally during prairie dog relocation--Colorado, 1998. (1/191)
On August 31, 1998, two suspected cases of fungal pneumonia were reported to the Boulder County (Colorado) Health Department (BCHD). Both patients were immunocompetent, otherwise healthy adults working for the City of Boulder Open Space (CBOS) program on a prairie dog relocation project. This report summarizes the epidemiologic investigation by BCHD, the Colorado Department of Public Health and Environment, and CDC; the findings indicate that these two persons acquired blastomycosis in Colorado, which is outside the area where the disease is endemic. (+info)Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis. (2/191)
Systemic fungal infections are becoming more common and difficult to treat, yet the pathogenesis of these infectious diseases remains poorly understood. In many cases, pathogenicity can be attributed to the ability of the fungi to adhere to target tissues, but the lack of tractable genetic systems has limited progress in understanding and interfering with the offending fungal products. In Blastomyces dermatitidis, the agent of blastomycosis, a respiratory and disseminated mycosis of people and animals worldwide, expression of the putative adhesin encoded by the WI-1 gene was investigated as a possible virulence factor. DNA-mediated gene transfer was used to disrupt the WI-1 locus by allelic replacement, resulting in impaired binding and entry of yeasts into macrophages, loss of adherence to lung tissue, and abolishment of virulence in mice; each of these properties was fully restored after reconstitution of WI-1 by means of gene transfer. These findings establish the pivotal role of WI-1 in adherence and virulence of B. dermatitidis yeasts. To our knowledge, they offer the first example of a genetically proven virulence determinant among systemic dimorphic fungi, and underscore the value of reverse genetics for studies of pathogenesis in these organisms. (+info)Endemic mycoses: a treatment update. (3/191)
Endemic mycoses remain a major public health problem in several countries and they are becoming increasingly frequent with the spread of HIV infection. Amphotericin B remains the drug of choice during the acute stage of life-threatening endemic mycoses occurring in both immunocompetent and immunocompromised hosts. Ketoconazole is effective in non-AIDS patients with non-life-threatening histoplasmosis, blastomycosis, or paracoccidioidomycosis. Itraconazole is the treatment of choice for non-life-threatening Histoplasma capsulatum or Blastomyces dermatitidis infections occurring in immunocompetent individuals and is the most efficient secondary prophylaxis of histoplasmosis in AIDS patients. Itraconazole is also effective in lymphocutaneous and visceral sporotrichosis, in paracoccidioidomycosis, for Penicillum marneffei infection, and is an alternative to amphotericin B for Histoplasma duboisii infection. Coccidioidomycosis may be effectively treated with prolonged and sometimes life-long itraconazole or fluconazole therapy. Fluconazole has relatively poor efficacy against histoplasmosis, blastomycosis and sporotrichosis. New antifungal agents have been tested in vitro or in animal models and may soon be evaluated in clinical trials. (+info)Thoracic blastomycosis and empyema. (4/191)
Blastomycosis is endemic in river valley areas of the southeastern and Midwestern United States. Pulmonary manifestations include chronic cough and pleuritic pain. Radiographic appearance of the infection can mimic bronchogenic lung carcinoma. Pleural effusion is rarely associated with this pulmonary infection, and empyema has not been previously reported. We report a case of pulmonary and pleural Blastomyces dermatitidis infection presenting as empyema thoracis. Diagnosis and treatment were attained with video-assisted thoracoscopic (VATS) pleural and lung biopsy and debridement. (+info)Disseminated blastomycosis in a rhesus monkey (Macaca mulatta). (5/191)
An 8-year-old male rhesus monkey (Macaca mulatta) died following a 6-day illness consisting of progressive depression, anorexia, labored abdominal breathing, coughing, and tachypnea. Gross necropsy findings included severe multifocal (miliary) granulomatous pneumonia, granulomatous splenitis, and multifocal cerebral abscesses. Histologic examination revealed 10-15-microm broad-based budding organisms within pyogranulomatous inflammatory lesions in the lung, tracheobronchial lymph node, brain, spleen, and liver. The distribution of extrapulmonary lesions was intermediate between that described for dogs and that described for humans. These findings were consistent with blastomycosis, which is previously unreported in nonhuman primates. (+info)T-Cell epitopes and human leukocyte antigen restriction elements of an immunodominant antigen of Blastomyces dermatitidis. (6/191)
Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display them were investigated. Peripheral blood mononuclear cells (PBMC) from 37 patients with a confirmed history of blastomycosis were tested for a response to WI-1 in primary proliferation assays; PBMC from 35 (95%) responded. Six patients whose PBMC proliferated strongly in response to WI-1 (defined as a stimulation index greater than 50) were tested further for responses to subcloned, recombinant fragments of the antigen. These patients responded chiefly to sequences within the N terminus and the 25-amino-acid tandem repeat. Cloned CD4(+) T cells from an infected individual were used to delineate more precisely the peptide epitopes in the fragments and HLA restricting elements that present them. A majority of the T-cell clones recognized an epitope spanning amino acids 149 to 172 within the N terminus, displayed by HLA-DR 15. A minority of the clones, which have been shown to perform a cytolytic function in vitro, recognized an epitope in the tandem repeat displayed by HLA-DPw4, an uncommon restricting element. Tandem repeat epitopes required display by the beta chain of DPw4 heterodimers. Thus, human T cells with different functions in vitro also recognize distinct regions of WI-1, raising the possibility that HLA restricting elements that present them could modulate immunity during blastomycosis by selection and display of WI-1 peptides. (+info)Jorge Lobo's disease: experimental inoculation in Swiss mice. (7/191)
Sixty-four isogenic Swiss mice were intradermically inoculated in both hind foot pads. The inocula, consisting of fungal suspensions from biopsies obtained from Jorge Lobo's Disease patients, had the total number of fungi and the viability index determined using a Neubauer chamber and the fluorescein diacetate-ethidium bromide technique (FD-EB), respectively. The animals were sacrificed at times ranging from ten days to eighteen months after inoculation. The cellular infiltrate, mainly consisting of macrophages containing fungi, increased progressively up to end of the study; however, no macroscopic alterations were observed in the inoculated feet. After nine months, small numbers of Langhans' giant cells started to appear in the infiltrate. A considerable number of fungi was observed at the end of the experimental period, but only a few were viable when stained by the FD-EB technique. This fact suggests that there is a multiplication of fungal cells, which are destroyed by the macrophages but remain in the tissue for a long time due perhaps to the difficulties in their elimination. These findings led us to conclude that in spite of the maintenance of the infection in these animals, Swiss mice cannot be considered an ideal model to study Jorge Lobo's Disease. However, the authors call attention to the possibility of other mouse strains being more susceptible to Paracoccidioides loboi. (+info)Molecular epidemiology of Blastomyces dermatitidis. (8/191)
The inhalation of conidia of Blastomyces dermatitidis, a fungus found in soil, causes disease in humans and animals. We studied the genetic diversity of this pathogen by extracting DNA yeasts and analyzing them with a polymerase chain reaction (PCR)-based typing system we developed, which used restriction fragment analysis of amplicons from the regions between the rDNA repeats and allowed us to class isolates into 3 major groups. Strains were further differentiated by use of PCR fingerprinting with 3 different primers. Fifty-nine isolates collected over 35 years from 15 regions (United States, India, Africa, Canada) were analyzed. Genotypic groups A, B, and C contained 17, 23, and 19 isolates, which were divided into 5, 15, and 12 types, respectively. All 16 isolates from North America in group A were from the upper midwestern United States or Canada, whereas 0 of 20 isolates from the southeastern United States were in group A. Studies of the largest collection from 1 locale (Eagle River, WI), revealed that the soil isolates studied were not responsible for the majority of cases in this outbreak, as previously proposed, and that >1 strain was present in the environment and in patients. Overall, these results provide a tool for the epidemiological study of blastomycosis and illuminate the genetic and geographic diversity of this important pathogen. (+info)The fungus is found in soil and water and is typically contracted through the inhalation of contaminated dust or the ingestion of contaminated food or water. The symptoms of blastomycosis can vary depending on the severity of the infection, but may include:
* Fever
* Cough
* Shortness of breath
* Skin lesions
* Joint pain
* Swollen lymph nodes
In severe cases, blastomycosis can lead to life-threatening complications such as respiratory failure, cardiovascular problems, and meningitis.
Diagnosis of blastomycosis is based on a combination of clinical findings, laboratory tests, and imaging studies. Treatment typically involves antifungal medications, which can be effective in resolving symptoms and preventing complications. However, the disease can be challenging to diagnose and treat, and long-term follow-up is often necessary to ensure that the infection has been fully cleared.
Preventive measures for blastomycosis include avoiding contact with contaminated soil and water, wearing protective clothing and equipment when working outdoors in areas where the fungus is prevalent, and taking antifungal medications as prescribed by a healthcare provider. Early diagnosis and treatment are critical to preventing severe complications and improving outcomes for patients with blastomycosis.
Types of fungal lung diseases include:
1. Aspergillosis: This is an infection caused by the fungus Aspergillus, which is commonly found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive drugs.
2. Cryptococcosis: This is an infection caused by the fungus Cryptococcus neoformans, which is found in soil and decaying wood. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
3. Histoplasmosis: This is an infection caused by the fungus Histoplasma capsulatum, which is found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
4. Pneumocystis pneumonia (PCP): This is an infection caused by the fungus Pneumocystis jirovecii, which is found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
5. Sporotrichosis: This is an infection caused by the fungus Sporothrix schenckii, which is found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
Symptoms of fungal lung diseases can include:
* Cough
* Fever
* Chest pain
* Shortness of breath
* Fatigue
Diagnosis of fungal lung diseases is typically made through a combination of physical examination, medical history, and laboratory tests such as chest X-rays, CT scans, and fungal cultures. Treatment usually involves antifungal medications and may also include supportive care to manage symptoms.
Prevention of fungal lung diseases includes:
1. Avoiding exposure to fungal spores by wearing protective clothing and gear when working with soil or decaying organic matter.
2. Maintaining good indoor air quality by using ventilation systems and reducing humidity.
3. Reducing the risk of infection by avoiding close contact with people who are at high risk of developing fungal lung diseases, such as those with weakened immune systems.
4. Avoiding smoking and other tobacco products, which can increase the risk of developing fungal lung diseases.
5. Managing underlying medical conditions, such as HIV/AIDS or taking immunosuppressive drugs, to reduce the risk of developing fungal lung diseases.
The most common types of CNS fungal infections include:
1. Meningitis: An inflammation of the membranes that cover the brain and spinal cord, caused by fungi such as Candida, Aspergillus, or Cryptococcus.
2. Encephalitis: An inflammation of the brain tissue itself, caused by fungi such as Histoplasma or Coccidioides.
3. Abscesses: Pocket of pus that form in the brain or spinal cord, caused by bacteria or fungi.
4. Opportunistic infections: Infections that occur in people with compromised immune systems, such as HIV/AIDS patients or those taking immunosuppressive drugs after an organ transplant.
CNS fungal infections can cause a wide range of symptoms, including headache, fever, confusion, seizures, and loss of coordination. They are typically diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans.
Treatment of CNS fungal infections usually involves the use of antifungal medications, which can be administered intravenously or orally. The choice of treatment depends on the severity and location of the infection, as well as the patient's overall health status. In some cases, surgery may be necessary to drain abscesses or relieve pressure on the brain.
Prevention of CNS fungal infections is important for individuals at risk, such as those with compromised immune systems or underlying medical conditions. This includes taking antifungal medications prophylactically, avoiding exposure to fungal spores, and practicing good hygiene.
Overall, CNS fungal infections are serious and potentially life-threatening conditions that require prompt diagnosis and treatment. With appropriate management, many patients can recover fully, but delays in diagnosis and treatment can lead to poor outcomes.
Here are 10 key points to remember about histoplasmosis:
1) Histoplasmosis is a fungal disease caused by Histoplasma capsulatum.
2) It primarily affects the lungs and can disseminate to other organs.
3) Inhalation of spores from contaminated soil or bird droppings leads to infection.
4) Symptoms range from mild to severe, including fever, cough, chest pain, fatigue, and difficulty breathing.
5) Diagnosis is based on clinical findings, laboratory tests, and imaging studies.
6) Treatment is primarily supportive, with antifungal medications for severe cases.
7) Prevention includes avoiding exposure to contaminated environments and wearing protective clothing during cleanup or construction activities.
8) Histoplasmosis has a global distribution and is found in many parts of the United States.
9) It is an important occupational hazard for workers involved in construction, mining, and agriculture.
10) In severe cases, histoplasmosis can lead to chronic lung disease, heart problems, and meningitis.
The symptoms of coccidioidomycosis can vary depending on the severity of the infection and the individual's immune response. Some people may experience mild symptoms, such as fever, cough, and fatigue, while others may develop more severe symptoms, including pneumonia, meningitis, and bone or skin infections. Skin lesions and rashes are also common.
Diagnosis of coccidioidomycosis typically involves a combination of physical examination, laboratory tests, and imaging studies. Treatment may involve antifungal medications and supportive care to manage symptoms. In severe cases, hospitalization may be necessary.
Prevention is key in avoiding coccidioidomycosis, which includes avoiding areas with high concentrations of the fungus, using respiratory protection when working in areas where the fungus is present, and taking antifungal medications prophylactically for those who are at high risk.
Prognosis for coccidioidomycosis is generally good for those with mild infections, but can be poor for those with severe infections or underlying conditions such as HIV/AIDS or cancer. Long-term effects of the infection can include lung scarring and joint damage.
Also found in: Medical, Encyclopedia.
Examples from the web for 'dermatomycoses'
Some common types of dermatomycoses include athlete's foot and jock itch.
Scientific American, 25 Mar. 2019.
Topical antifungal medications are effective against most types of dermatomycoses.
Britannica.com: encyclopedia article about dermatomycoses.
This condition is caused by a type of fungus that affects the skin, known as dermatomycoses.
Mayo Clinic, 01 Mar. 2020.
The disease typically presents with symptoms such as fever, cough, fatigue, weight loss, and night sweats, and can progress to severe respiratory, cutaneous, and disseminated forms if left untreated. The infection is diagnosed through a combination of clinical evaluation, radiological studies, and laboratory tests such as PCR and culture.
Treatment options for paracoccidioidomycosis include antifungal medications such as amphotericin B, fluconazole, and itraconazole, which are often associated with significant side effects and variable efficacy. Surgical debulking may also be considered in certain cases.
The prognosis for paracoccidioidomycosis is generally poor, especially in advanced stages of the disease, with high rates of morbidity and mortality. However, early diagnosis and appropriate treatment can improve outcomes.
Blastomycosis
Blastomycosis-like pyoderma
Cold abscess
Rhoda Williams Benham
Blastomyces dermatitidis
Richard Summerbell
Periodontal disease
Paracoccidioidomycosis
Albert Balows
Dog health
Acid-fastness
Itraconazole
Pseudomonal pyoderma
Emergency management
Fluconazole
Lorraine Friedman
Paracoccidioides brasiliensis
Histoplasma capsulatum
Rickettsia
Fever of unknown origin
Fungal meningitis
Fungal infection
Howard Taylor Ricketts
List of dog diseases
Granuloma
Tuberculosis verrucosa cutis
Emmonsiosis
Mouth ulcer
Amphotericin B
Lobomycosis
Blastomycosis | Fungal Diseases | CDC
Blastomycosis: MedlinePlus Medical Encyclopedia
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Etymologia: Blastomycosis - Volume 20, Number 11-November 2014 - Emerging Infectious Diseases journal - CDC
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Histoplasmosis11
- The endemic mycoses blastomycosis, coccidioidomycosis (Valley fever), and histoplasmosis are environmental fungal diseases that are frequently misdiagnosed. (cdc.gov)
- Participants will also be introduced to new clinical diagnostic algorithms to address these challenges and improve the timely diagnosis of blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Describe the epidemiology of blastomycosis, coccidioidomycosis, and histoplasmosis in the United States and the impact of delayed and underdiagnosed cases. (cdc.gov)
- Discuss diagnostic challenges associated with blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Identify populations clinicians should consider testing for blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Describe diagnostic tests clinicians should consider initially and after a negative test for blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Discuss the implementation of the clinical diagnostic algorithms for blastomycosis, coccidiomycosis, and histoplasmosis. (cdc.gov)
- Estimates for the annual incidence of HIV-related life-threatening fungal disease include cryptococcal meningitis (8 357 cases), Pneumocystis pneumonia (4 452 cases) and endemic mycoses (emergomycosis, histoplasmosis and blastomycosis, with 100, 60 and 10 cases per year, respectively). (who.int)
- PURPOSE The National Heart, Lung, and Blood Institute (NHLBI) invites research grant applications for support of research on the cellular and molecular mechanisms that influence host susceptibility to HIV-associated lung diseases, including tuberculosis, histoplasmosis, coccidioidomycosis, blastomycosis, Pneumocystis carinii pneumonia, and pulmonary Kaposi's sarcoma. (nih.gov)
- Ketoconazole is a prescription medication used to treat fungal infections, including the following: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis for patients in which other treatments have failed or who are intolerant to other therapies. (rxwiki.com)
- Ketoconazole tablets are prescription medicine used to treat serious fungal infections including: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. (nih.gov)
Endemic mycoses1
- Among the endemic mycoses, blastomycosis has been least often associated with disorders of immune function, but the data presented herein suggest that blastomycosis may occur more commonly in immunocompromised patients than was previously recognized. (nih.gov)
Blastomyces5
- Blastomycosis is an infection caused by a fungus called Blastomyces . (cdc.gov)
- Blastomycosis is an infection caused by breathing in the Blastomyces dermatitidis fungus. (medlineplus.gov)
- Blastomycosis is an uncommon infection caused by Blastomyces dermatitidis . (bvsalud.org)
- Diana Khuu] Blastomycosis is a fungal disease caused by blastomyces dermatitidis. (cdc.gov)
- Diana Khuu] We decided to do this study because, even though we know quite a bit about the biology and risk factors of infection by Blastomyces dermatitidis , the public health burden of blastomycosis deaths in the United States was unknown. (cdc.gov)
Aspergillosis1
- mycotic (fungal) diseases like aspergillosis, blastomycosis among others. (jcehrlich.com)
Amphotericin2
Diagnosis3
- Almost 30% of the patients in our series died secondary to blastomycosis, with most deaths occurring within 5 weeks following the diagnosis. (nih.gov)
- This case showcases the variety of blastomycosis clinical presentation and the importance of blastomycosis in the differential diagnosis of verrucous and papillomatous mucocutaneous lesions. (bvsalud.org)
- In regions where blastomycosis is endemic, the diagnosis should be considered in patients with pulmonary disease. (cdc.gov)
Symptoms2
- Contact your provider if you have symptoms of blastomycosis. (medlineplus.gov)
- Just looked up blastomycosis and he does not present the symptoms. (askavetquestion.com)
Clinical1
- Clinical and laboratory update on blastomycosis. (cdc.gov)
Deaths2
- After looking at blastomycosis deaths from 1990 to 2010 death certificate data, we found that blastomycosis deaths were more likely in older people, men, and Native Americans, or blacks. (cdc.gov)
- We wanted to look at these risk factors among blastomycosis deaths and see if the risk factors extended to mortality rates. (cdc.gov)
Fungus1
- exposed to areas where the fungus could be found, it might be important to ask your doctor to test for blastomycosis. (cdc.gov)
Patients4
- We have observed a marked increased in the number of immunocompromised patients with blastomycosis over the last 15 years, increasing from about 3% of patients seen between 1956 and 1977 to almost 24% patients seen between 1978 and 1991. (nih.gov)
- Furthermore, almost one third of those patients who died of other causes had evidence of persistent blastomycosis at death. (nih.gov)
- Until more data are available, the newer azoles should be used with caution as primary therapy in immunocompromised patients with blastomycosis, and considered only in patients with limited disease and a stable underlying condition. (nih.gov)
- The clearer resulting identification of risk factors from national data may raise provider and community awareness of blastomycosis to make blastomycosis a diagnostic consideration in patients with lung disease. (cdc.gov)
Commonly1
- You can get blastomycosis by contact with moist soil, most commonly where there is rotting wood and leaves. (medlineplus.gov)
Article1
- Diana Khuu is an author on the article, "Blastomycosis Mortality Rates, United States, 1990 to 2010. (cdc.gov)
Disease2
- Rarely fungal disease (e.g. blastomycosis) and cancer may be found in the joint. (vcahospitals.com)
- Similarly, a fungal disease like blastomycosis could do this. (askavetquestion.com)
Case1
- An Atypical Case of Mucocutaneous Blastomycosis in the Greater Toronto Area. (bvsalud.org)
Death1
- So blastomycosis continues to be a noteworthy cause of preventable death in the United States. (cdc.gov)
People4
- People can get blastomycosis after breathing in the microscopic fungal spores from the air. (cdc.gov)
- Diana, what is important for people to know about blastomycosis mortality rates and blastomycosis in particular? (cdc.gov)
- Anyone can get blastomycosis, even people who are otherwise healthy. (cdc.gov)
- An interesting finding is that even though people of Asian descent are at lower risk of dying from blastomycosis than whites, they died at a much younger age. (cdc.gov)
Last week1
- As we discussed last week, the Billerud Paper Mill has a blastomycosis problem. (foodmanufacturing.com)
Culture1
- Blastomycosis can be diagnosed by culture, direct visualization of the yeast in affected tissue, and/or antigen testing. (nih.gov)
Medicine1
- You may not need to take medicine for a mild blastomycosis infection that stays in the lungs. (medlineplus.gov)
Histoplasmosis7
- Histoplasmosis and blastomycosis. (medscape.com)
- Participants will also be introduced to new clinical diagnostic algorithms to address these challenges and improve the timely diagnosis of blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Describe the epidemiology of blastomycosis, coccidioidomycosis, and histoplasmosis in the United States and the impact of delayed and underdiagnosed cases. (cdc.gov)
- Discuss diagnostic challenges associated with blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Identify populations clinicians should consider testing for blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Describe diagnostic tests clinicians should consider initially and after a negative test for blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Discuss the implementation of the clinical diagnostic algorithms for blastomycosis, coccidiomycosis, and histoplasmosis. (cdc.gov)
Pulmonary blastomycosis4
- Delays in diagnosis of pulmonary blastomycosis can be reduced if a higher clinical suspicion exists and there is earlier use of sputum potassium hydroxide (KOH) fungal smear, especially after a course of antibiotics has failed to result in clinical improvement. (medscape.com)
- Pulmonary blastomycosis may resemble lung cancer, and blastomycosis osteomyelitis may resemble bony metastasis. (medscape.com)
- Pulmonary blastomycosis. (nih.gov)
- Chronic pulmonary blastomycosis is often misdiagnosed and treated as tuberculosis in disease-endemic and non-disease-endemic areas. (cdc.gov)
Gilchrist1
- Gilchrist first described blastomycosis in 1894, mistakenly attributing the disease to a protozoan. (medscape.com)
Laryngeal2
Diagnoses1
- A doctor diagnoses blastomycosis by sending a sample of sputum or infected tissue to a laboratory to be examined under a microscope and cultured. (msdmanuals.com)
Extrapulmonary2
- Chronic pneumonia is the dominant clinical manifestation of blastomycosis, although extrapulmonary disease is common, usually involving skin and subcutaneous tissue, bones and joints, the prostate gland, and the central nervous system (CNS). (medscape.com)
- Blastomycosis can be a subclinical illness with subsequent protection against progressive infection afforded by cellular immune mechanisms, but it may present with progressive disease with either pulmonary or extrapulmonary disease or both. (nih.gov)
Lungs3
- You may not need to take medicine for a mild blastomycosis infection that stays in the lungs. (medlineplus.gov)
- Thus, blastomycosis affects primarily the lungs, but the fungi occasionally spread through the bloodstream to other areas of the body, most commonly the skin. (msdmanuals.com)
- Sometimes blastomycosis of the lungs causes no symptoms or causes symptoms that disappear quickly and are not recognized. (msdmanuals.com)
19902
- Diana Khuu is an author on the article, "Blastomycosis Mortality Rates, United States, 1990 to 2010. (cdc.gov)
- After looking at blastomycosis deaths from 1990 to 2010 death certificate data, we found that blastomycosis deaths were more likely in older people, men, and Native Americans, or blacks. (cdc.gov)
Clinically1
- The term North American blastomycosis , a commonly uses synonym, evolved to distinguish this disorder from the clinically similar South American blastomycosis, a disease caused by Paracoccidioides brasiliensis . (medscape.com)
Clinical3
- Clinical and laboratory update on blastomycosis. (medscape.com)
- Clinical practice guidelines for the management of blastomycosis: 2008 update by the Infectious Diseases Society of America. (medscape.com)
- Endemic blastomycosis in Mississippi: epidemiological and clinical studies. (medscape.com)
Systemic1
- Chronic blastomycosis should always be treated with systemic antifungal therapy, and oral itraconazole is the drug of choice for mild to moderate forms of the disease. (medscape.com)
Spores1
- People can get blastomycosis after breathing in the microscopic fungal spores from the air. (cdc.gov)
Lung1
- Blastomycosis: fungal infections of the lung update: 1989. (nih.gov)
Chronic1
- Most cases of blastomycosis are usually diagnosed after the infection has become chronic. (cdc.gov)
Pneumonia2
- Establishing blastomycosis as the cause of pneumonia is often difficult, and most patients received multiple antibiotic courses before being diagnosed. (medscape.com)
- In the acute stage, blastomycosis may be misdiagnosed as bacterial pneumonia and sometimes as another illness. (cdc.gov)
Endemicity1
- Notes from the field: Blastomycosis cases occurring outside of regions with known endemicity - New York, 2007-2017. (medscape.com)
Mild1
- Patients with mild to moderate disseminated blastomycosis without central nervous system involvement should be treated for 6 months. (medscape.com)
Patient2
- Composite photomicrograph of a tissue specimen from a patient with blastomycosis infection shows an abundance of large budding cells that had been configured in chains. (medscape.com)
- Patient with blastomycosis, India, 2014. (cdc.gov)
Suspicion1
- Because of strong suspicion of a fungal infection, probably blastomycosis, and considering the patient's stay in Chicago, anti-TB therapy was replaced with itraconazole at a dose of 200 mg 2×/d. (cdc.gov)
Cases1
- It was not until 1951, following the detailed pathologic description of blastomycosis by Schwarz and Baum, [ 9 ] that it was discovered that most cases of the disorder were acquired via the respiratory, not cutaneous, route of inoculation. (medscape.com)
Central nervou1
- Central nervous system blastomycosis may resemble brain neoplasm. (medscape.com)
Skin1
- The typical verrucous or ulcerative cutaneous lesions of blastomycosis may mimic skin cancers, such as basal cell carcinoma and squamous cell carcinoma. (medscape.com)
Treatment1
- Blastomycosis requires prolonged treatment. (medscape.com)
Regions1
- The blastomycosis mortality rates were highest in the Midwestern and Southern regions, and we saw that the mortality rate in the Midwestern region has been increasing over the last two decades. (cdc.gov)