Blast crisis. Medical search

An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.

Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.

Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.

BENZOIC ACID amides.

Brief therapeutic approach which is ameliorative rather than curative of acute psychiatric emergencies. Used in contexts such as emergency rooms of psychiatric or general hospitals, or in the home or place of crisis occurrence, this treatment approach focuses on interpersonal and intrapsychic factors and environmental modification. (APA Thesaurus of Psychological Index Terms, 7th ed)

Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)

The phase of chronic myeloid leukemia following the chronic phase (LEUKEMIA, MYELOID, CHRONIC-PHASE), where there are increased systemic symptoms, worsening cytopenias, and refractory LEUKOCYTOSIS.

A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.

An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).

The short, acrocentric human chromosomes, called group G in the human chromosome classification. This group consists of chromosome pairs 21 and 22 and the Y chromosome.

Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.

The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.

Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

The parent cells that give rise to both cells of the GRANULOCYTE lineage and cells of the monocyte/macrophage lineage.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.

Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.

A dangerous life-threatening hypermetabolic condition characterized by high FEVER and dysfunction of the cardiovascular, the nervous, and the gastrointestinal systems.

An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Mapping of the KARYOTYPE of a cell.

A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.

A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.

Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

A specific pair of GROUP C CHROMSOMES of the human chromosome classification.

Disease having a short and relatively severe course.

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

Significant decline in economic activity spread across the economy, lasting more than a few months, normally visible in real gross domestic product, real income, employment, industrial production, and wholesale-retail sales. (National Bureau of Economic Research, Inc, www.nber.org/cycles.html, accessed 4/23/2009)

Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.

Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.

The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.

Progenitor cells from which all blood cells derive.

A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.

Therapeutic act or process that initiates a response to a complete or partial remission level.

Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.

Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.

RNA present in neoplastic tissue.

A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthophosphate. EC 3.1.3.-.

A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.

Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.

Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.

Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.

Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.

Catalyze the hydrolysis of nucleosides with the elimination of ammonia.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

DNA present in neoplastic tissue.

A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.

A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.

White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Agents that inhibit PROTEIN KINASES.

Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.

An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.

The return of a sign, symptom, or disease after a remission.

Books designed to give factual information or instructions.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Toward a leukemia treatment strategy based on the probability of stem cell death: an essay in honor of Dr. Emil J Freireich. (1/479)

Dr. Emil J Freireich is a pioneer in the rational treatment of cancer in general and leukemia in particular. This essay in his honor suggests that the cell kill concept of chemotherapy of acute myeloblastic leukemia be extended to include two additional ideas. The first concept is that leukemic blasts, like normal hemopoietic cells, are organized in hierarchies, headed by stem cells. In both normal and leukemic hemopoiesis, killing stem cells will destroy the system; furthermore, both normal and leukemic cells respond to regulators. It follows that acute myelogenous leukemia should be considered as a dependent neoplasm. The second concept is that cell/drug interaction should be considered as two phases. The first, or proximal phase, consists of the events that lead up to injury; the second, or distal phase, comprises the responses of the cell that contribute to either progression to apoptosis or recovery. Distal responses are described briefly. Regulated drug sensitivity is presented as an example of how distal responses might be used to improve treatment. (+info)

Prognostic significance of bone marrow biopsy in essential thrombocythemia. (2/479)

BACKGROUND AND OBJECTIVE: The diagnostic and prognostic value of bone marrow biopsy (BMB) has been widely investigated in patients with chronic myeloproliferative disorders (CMPD). The present study is based on a review of the results of routine BMBs taken from 93 essential thrombocythemia (ET) patients at the time of diagnosis. DESIGN AND METHODS: The common BMB histologic parameters and clinico-hematologic variables were considered for diagnostic and prognostic purposes. Clinico-pathologic correlations were looked for univariately. Moreover, the diagnostic significance of the histologic findings was tested by means of cluster analysis. Overall survival and event-free survival were considered as prognostic endpoints. RESULTS: There were no correlations between the clinic and pathologic findings, and none of the histologic and clinical parameters was predictive of survival or the occurrence of major clinical events. Cluster analysis of the BMB findings revealed two distinct morphologic patterns: one was clearly myeloproliferative; the other had somewhat dysplastic features. The event-free and overall survival rates in the latter group were significantly worse (p = 0.0377 and p = 0.0162 respectively), with major ischemic events accounting for most of the difference in event-free survival. INTERPRETATION AND CONCLUSIONS: These results have no clearcut counterpart in the literature, but we feel that dysplastic BMB findings could be included in the definition of ET prognostic scores in order to allow therapeutic strategies to be adapted to the level of risk. (+info)

Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. (3/479)

Studies in cell lines have indicated that expression of the BCL-2 family of proteins is an important determinant of chemotherapy-induced apoptosis; however, the level of expression of these proteins in childhood acute lymphoblastic leukemia (ALL) has not been extensively reported. Using quantitative Western blotting we have determined the level of expression of BCL-2, BAX, MCL-1, and BCL-X in lymphoblasts from 47 children with ALL (33 at presentation only, 4 at relapse only, and 10 at both presentation and on relapse). Results were determined as a ratio to actin as an internal control. BCL-2, BAX, and MCL-1 were detected in all samples. BCL-XL was only detected in 6 cases (4 at presentation and 2 at relapse) and BCL-XS in none. No correlation was found between expression and white blood cell count, age at diagnosis, gender, or blast karyotype. BCL-2 levels and the BCL/BAX and MCL-1/BAX ratios were found to be significantly higher in B-lineage as compared with T-lineage disease (P <.003,.02, and.02, respectively). No consistent pattern of change in expression was noted in the 10 cases studied at both presentation and relapse. Kaplan-Meier analysis showed a significant correlation between high BAX expression and an increased probability of relapse (P <.05 by the log rank test), suggesting that chemosensitivity in leukemic blasts may be regulated by factors that override the BCL-2 pathway. (+info)

Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. (4/479)

The two matrix metalloproteinases (MMPs) Mr 72,000 type IV collagenase (MMP-2, gelatinase A) and Mr 92,000 type IV collagenase (MMP-9, gelatinase B) play key roles in tissue remodeling and tumor invasion by digestion of extracellular matrix barriers. We have investigated the production of these two enzymes as well as the membrane-type MMP (MT1-MMP) and the tissue inhibitors of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 in the bone marrow mononuclear cells (BM-MNCs) of patients with acute myeloid leukemia (AML; n = 24), chronic myeloid leukemia (CML; n = 17), myelodysplastic syndromes (MDS; n = 8), and healthy donors (n = 5). Zymographic analysis of BM-MNC-conditioned medium showed that a Mr 92,000 gelatinolytic activity, identified as MMP-9 by Western blotting, was constitutively released from cells of all patients and healthy individuals examined in this study. In contrast, MMP-2 secretion was found to be absent in all samples from healthy donors but present in 8 of 11 (73%) of the samples from patients with primary AML, 7 of 8 (88%) with secondary AML, and only 1 of 5 (20%) cases with AML in remission, indicating MMP-2 to be produced by the leukemic blasts. MMP-2 release was not detected in CML cell-conditioned medium with the exception of two cases, both patients either being in or preceding blast crisis. In MDS, MMP-2 was found in three of eight (38%) of the patients, two of them undergoing progression of disease within 12 months. Quantitative Northern blot analysis in freshly isolated BM-MNCs showed a relatively low constitutive expression of TIMP-1 in all samples, whereas MMP-9 gene transcription was higher in healthy donors and CML samples, than in AML and MDS. Reverse transcriptase-PCR analysis revealed the presence of TIMP-2 mRNA in the majority of MMP-2-releasing BM-MNCs. MT1-MMP expression was present in most samples of patients with MDS or AML but absent in those with secondary AML and CML. Thus, we have shown that BM-MNCs continuously produce MMP-9 and TIMP-1 and demonstrated that leukemic blast cells additionally secrete MMP-2 representing a potential marker for dissemination in myeloproliferative malignancies. (+info)

Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. (5/479)

A novel type II integral membrane protein has been identified in the course of screening for genes overexpressed in a mouse model of chronic myelogenous leukemia blast crisis. This new protein, designated NKCL, consists of a 210-amino acid polypeptide with a short, NH2-terminal cytoplasmic tail of 17 amino acids preceding a transmembrane domain and a COOH-terminal extracellular region. The COOH-terminal 132 amino acids bear typical features of the C-type animal lectin carbohydrate-recognition domain. The Nkcl gene is unique in that it maps just proximal to the region of the genome that encodes group V members of the C-type animal lectin family near the natural killer gene complex on mouse chromosome 6, but its protein product also has features of several group II C-type animal lectins. Most notably, it has a complete Ca2+-binding site 2, which forms part of the sugar-binding site in other members of the family, and binds mannose in a Ca2+-dependent manner. Moreover, its expression is not restricted to natural killer cells, as reported for the majority of group V lectins. Nkcl is expressed in pluripotent myeloid precursors, precursor and mature macrophages, and neutrophils. (+info)

Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia. (6/479)

Thirty-six adults with chronic myelogenous leukemia (CML) in second or greater chronic phase, accelerated phase, or blast crisis underwent marrow or blood stem cell transplantation from an HLA-matched sibling using high-dose thiotepa, busulfan and cyclophosphamide (TBC) as the preparative regimen. All evaluable patients engrafted and had complete donor chimerism. One patient failed to clear meningeal leukemia, and one patient had one of 30 metaphases positive for the Philadelphia chromosome at 2 months post transplant. The remainder of the patients studied had eradication of CML documented by cytogenetics and/or Southern blot for BCR gene rearrangement, and 13 of 15 patients studied became negative for the BCR gene rearrangement by polymerase chain reaction. Three-year relapse rate is 42% (95% CI, 19-64%). The relapse rate was significantly lower for patients transplanted without blast crisis (9% vs 100%, P < 0.001). Eight (22%, 95% CI, 10-39%) patients had severe or fatal veno-occlusive disease (VOD). Elevated liver enzymes within 1 month prior to transplantation and transplantation using marrow were significantly associated with the occurrence of VOD. Three-year survival is 28% (95% CI, 13-43%). Survival was significantly higher for patients transplanted without blast crisis (45% vs 0%, P = 0.01). TBC is an effective preparative regimen for CML in accelerated phase but not refractory blast crisis, and it should be used with caution in patients with prior hepatopathy who have an increased risk of severe VOD. (+info)

Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. (7/479)

Gene targeting studies in mice have shown that the lack of Ikaros activity leads to T-cell hyperproliferation and T-cell neoplasia, establishing the Ikaros gene as a tumor suppressor gene in mice. This prompted us to investigate whether mutations in Ikaros play a role in human hematological malignancies. Reverse transcription-PCR was used to determine the relative expression levels of Ikaros isoforms in a panel of human leukemia/lymphoma cell lines and human bone marrow samples from patients with hematological malignancies. Among the cell lines examined, only BV-173, which was derived from a chronic myelogenous leukemia (CML) patient in lymphoid blast crisis, overexpressed the dominant-negative isoform, Ik-6. In 9 of 17 samples of patients in blast crisis of CML, Ikaros activity had been reduced either by drastically reducing mRNA expression (4 of 17) or by overexpressing the dominant-negative isoform Ik-6 (5 of 17). Significantly, expression of Ikaros isoforms seemed normal in chronic phase CML patients and patients with other hematological malignancies. In some cases, overexpression of the dominant-negative Ik-6 protein was confirmed by Western blot analysis, and Southern blot analysis indicated that decreases in Ikaros activity correlated with a mutation in the Ikaros locus. In summary, these findings suggest that a reduction of Ikaros activity may be an important step in the development of blast crisis in CML and provide further evidence that mutations that alter Ikaros expression may contribute to human hematological malignancies. (+info)

Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance. (8/479)

Expression of the multidrug resistance (MDR) mechanisms P-glycoprotein (Pgp) and MDR-related protein (MRP) decrease cellular retention and consequently cytotoxicity of anthracyclines. MDR is expressed on normal human hematopoietic progenitors and leukemic blasts. Normal CD34(+) progenitors showed rhodamine efflux in 20% to 30% of the cells, which could be blocked by verapamil. These cells appeared noncycling, in contrast to the proliferating rhodamine bright (RhoB) cells. We postulated that MDR expression can be downregulated by proliferation induction. Triggering rhodamine dull (RhoD) CD34(+) cells to proliferate indeed resulted in a higher rhodamine retention and significantly decreased efflux modulation by verapamil (P =.04). Also in acute myeloid leukemia (AML), the proliferation rate (percentage S/G(2)+M and Iododeoxyuridine labelings index) was significantly less in the RhoD blasts (P +info)

Warrior Crisis Deadline Blast! Greg S. Baisden, Jean-Paul Jennequin, Jacques Dutrey, Nick Hasted, and Brad Brooks. "NEWSWATCH ... Two of its stories were concluded in another Fleetway publication, Crisis (Crisis itself folded a few months later). The ... "Crisis Folds, Fleetway Merges", The Comics Journal #146 (Nov. 1991), p. 22. Rigby, Regie. "Fool Britannia: 'These I Have Loved ... After Revolver's cancellation, Dare and Happenstance and Kismet were completed in the pages of Crisis. Dare was collected into ...

https://en.wikipedia.org/wiki/Revolver_(Fleetway_comics)

Chronic myelogenous leukemia blast crisis. He had undergone several chemotherapy sessions since he was diagnosed the previous ...

https://en.wikipedia.org/wiki/Francis_Magalona

"Blasts escalate Japan's nuclear crisis". World News Australia. 16 March 2011. Archived from the original on 7 April 2011. David ... While stepping-up monitoring of radiation levels on its own shores in face of the Fukushima nuclear power plant crisis, China, ... In response to the crisis, the Japanese government mobilized the Self-Defence Forces, while many countries sent search and ... The ministry excluded Fukushima from the results because of the ongoing nuclear crisis. The reconstruction of damaged areas in ...

https://en.wikipedia.org/wiki/Aftermath_of_the_2011_Tōhoku_earthquake_and_tsunami

"Blasts escalate Japan's nuclear crisis". World News Australia. March 16, 2011. Archived from the original on April 7, 2011. ... Amoco Cadiz oil spill off the coast of France in 1978 Draining of the Mesopotamian Marshes in the 1990s Red Hill water crisis ... from the chemical manufacturing operations of the Army and its lessee Shell Chemicals company Nigeria gully erosion crisis, ...

https://en.wikipedia.org/wiki/List_of_environmental_disasters

"Blasts escalate Japan's nuclear crisis". World News Australia. 16 March 2011. Archived from the original on 7 April 2011. David ... "NEWS ANALYSIS: Japan crisis puts global nuclear expansion in doubt". Platts. 21 March 2011. "Nuclear power: When the steam ... Increased interest in climate change mitigation, low-carbon energy and global energy crisis resulted in what was described as ... "How nuclear power plants could help solve the climate crisis". CNET. Retrieved 15 December 2021. "Germany to widely miss 2030 ...

https://en.wikipedia.org/wiki/Nuclear_power_debate

Sabaghi, Dario (27 September 2020). "Invisible wounds: Beirut witnesses mental-health crisis after blast". Middle East Eye. ... 1979 energy crisis in the United States 2004 Indian Ocean earthquake and tsunami in Indonesia Sri Lanka, and Thailand 2011 ... and the Khmer Rouge in Cambodia Chernobyl disaster in Ukraine and Belarus Century of humiliation in China Cuban Missile Crisis ... States Great Famine in Ireland Great Kanto earthquake in Japan The Holocaust for European Jewish peoples Iran hostage crisis in ...

https://en.wikipedia.org/wiki/National_trauma

"Ukraine crisis: Deadly bomb blast hits rally in Kharkiv". BBC News. 2015-02-22. Retrieved 2015-04-19. (CS1 uses Russian- ... "The crisis in Ukraine". theday.co.uk. 2014-09-11. Retrieved 2015-07-30. Andrew Wilson (October 2014). "The High Stakes of the ... The number of deaths during the 2013-2014 Ukraine crisis climbed to just over 200 during the Euromaidan protests and the ... Saul, Heather; Sengupta, Kim (2014-03-19). "Ukraine crisis: Pro-Russian troops storm naval base as Clinton warns of 'aggression ...

https://en.wikipedia.org/wiki/Casualties_during_the_2013–2014_Ukraine_crisis

"Lebanon's Deepening Economic Crisis Laid Bare by Beirut Blast". BloombergQuint. Retrieved 19 September 2020. Yee, Vivian (7 ... The crisis became worse when the COVID-19 pandemic affected the Lebanese economy. In 2020, the country defaulted for the first ... The liquidity crisis also lead to a restriction on the withdrawals from US dollar bank accounts. Depositors needed to preserve ... This economic crisis made Lebanon's gross domestic product fall to about $44 billion, which was about $55 billion the year ...

https://en.wikipedia.org/wiki/Economy_of_Lebanon

"Lebanese government in crisis as ministers resign after blast". The Washington Post. 2020-08-10. Retrieved 2020-08-10.{{cite ... "Lebanon's Kataeb Party says its three MPs resigning from parliament in wake of Beirut blast". August 8, 2020 - via www.reuters. ... "Politician Paula Yacoubian says she risks her life fighting Lebanese corruption and garbage crisis". Euronews. 13 September ...

https://en.wikipedia.org/wiki/Paula_Yacoubian

Their inactivation is related with progression into blast crisis. BCR/ABL pathway could also active PI64K/Akt/STAT5 pathway ... Some new translocate case of BAL has been reported, such as t(15,17) and t(12,13). For t(15;17), the blasts with morphology of ... BAL is difficult to treat, most patients receive treatment based on the morphology of blasts and get AML or ALL induction ... Usually the chemotherapy is chosen according to the morphology of the blast (ALL or AML). A blood-forming stem-cell ...

https://en.wikipedia.org/wiki/Biphenotypic_acute_leukaemia

Connolly, Kevin (21 November 2012). "Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC News. Retrieved 3 June 2013. Why ... "Terror attack: Blast on Tel Aviv bus; 28 hurt". Ynet News. 21 November 2012. Retrieved 27 January 2013. Lazaroff, Tovah (16 ... Hamas's military wing claimed responsibility for the blast, stating that it was in response to the killing of the boy. ... "Deprived and Endangered: Humanitarian Crisis in the Gaza Strip". Human Rights Watch. 13 January 2009. Retrieved 3 September ...

https://en.wikipedia.org/wiki/2012_Israeli_operation_in_the_Gaza_Strip

"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. 21 November 2012. Archived from the original on 23 April 2013. ... "Blast on bus in heart of Tel Aviv". Ynet News. 21 November 2012. Archived from the original on 29 March 2019. Retrieved 21 ... During the operation, a bomb blast on a bus wounded at least 28 civilians, three seriously. This was described as a terrorist ... Serge Schmemann (5 March 2010). "Bombing in Israel:The Overview;4th Terror Blast in Israel Kills 14 at Mall in Tel Aviv; Nine- ...

https://en.wikipedia.org/wiki/Tel_Aviv

"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. November 21, 2012. Retrieved November 21, 2012. "Hamas leader tells ... "Terror attack: Blast on Tel Aviv bus; 28 hurt". Ynet News. November 21, 2012. Retrieved November 21, 2012. "הפיצוץ בת"א: "חשבנו ...

https://en.wikipedia.org/wiki/2012_Tel_Aviv_bus_bombing

"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. 21 November 2012. Retrieved 21 November 2012. "UN chief Ban Ki-moon ... The blast on the bus occurred in an area with many office buildings and heavy pedestrian traffic. The bus bombing complicated ... "Israel blasts Hamas police building on sixth day of conflict". AFP via ABC News. 18 November 2012. Retrieved 19 November 2012. ... "Terror attack: Blast on Tel Aviv bus; 28 hurt". Ynet News. 21 November 2012. Retrieved 21 November 2012. "21 wounded in terror ...

https://en.wikipedia.org/wiki/Timeline_of_Operation_Pillar_of_Defense

"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. November 21, 2012. Retrieved November 21, 2012. Hamas to gain ... many Arab states that backed the coalition cut off funds to the PLO which brought the PLO to the brink of crisis. In the ...

https://en.wikipedia.org/wiki/History_of_the_Israeli–Palestinian_conflict

Mroue, Bassem; Keller, Greg (10 September 2012). "Syria Crisis: Aleppo Car Bomb Blast Kills At Least 30". Huffington Post. ... The state news agency SANA reported the deaths of three Syrian troops as a result of a bomb blast, with an officer also ... "Humanitarian crisis looms in south Syria town amid ongoing government siege". Al-Monitor. 10 July 2021. Archived from the ... "Syria crisis: Spooked by rebel gains, Jordan doubles down on Islamic State". The Christian Science Monitor. 4 May 2015. ...

https://en.wikipedia.org/wiki/Free_Syrian_Army

Mroue, Bassem; Keller, Greg (10 September 2012). "Syria Crisis: Aleppo Car Bomb Blast Kills At Least 30". Huffington Post. ... Syrian Crisis. New York City, NY: UNICEF. [2] Burack, Cristina. 2020. 5 Million Syrian Children in Need Due to War. Germany: DW ... "Syrian crisis". www.unicef.org. Retrieved 5 May 2020. Welle, Deutsche. "5 million Syrian children in need due to war , DW , ... "Syria Crisis Fast Facts". www.unicef.org. Retrieved 5 May 2020. "Help Children in Syria". Save the Children. Retrieved 5 May ...

https://en.wikipedia.org/wiki/Human_rights_violations_during_the_Syrian_civil_war

Mroue, Bassem; Keller, Gereg (10 September 2012). "Syria Crisis: Aleppo Car Bomb Blast Kills At Least 30". Huffington Post. ... During four hours of fighting rebels tried to blast holes in the walls of the mosque with RPGs before storming the site but ... "Syrian forces blast rebel-held districts of Aleppo, according to activists". Al Jazeera. 30 July 2012. Retrieved 29 July 2012. ... On 21 October, "a suicide car bomber" caused a blast in the New Syriac quarter wounding several people and damaging the Syrian- ...

https://en.wikipedia.org/wiki/Combat_operations_in_2012_during_the_Battle_of_Aleppo

Hiyama, Hiroshi (15 March 2011). "Blasts, new fire escalate Japan's nuclear crisis". AFP. Retrieved 26 March 2011. "TEPCO ... "Japan nuclear crisis: Meltdown at Fukushima Daiichi plant may now be inevitable". The New York Daily News. 17 March 2011. ... "TEPCO: Unit No.4 blast due to hydrogen from Unit No.3". NHK. 16 May 2011. Archived from the original on 15 May 2011. Retrieved ... "Crisis continues at crippled Japanese nuclear power plants". VOA. 16 March 2011. Retrieved 26 March 2011. JAIF (26 June 2012) ...

https://en.wikipedia.org/wiki/Fukushima_Daiichi_units_4,_5_and_6

Lippman, Daniel (April 21, 2020). "Democrats blast Trump team's handling of federal workers in coronavirus crisis". Politico. ...

https://en.wikipedia.org/wiki/George_Nesterczuk

"Nigeria's Boko Haram crisis: Jos blasts kill scores". BBC News. 2015-07-06. Retrieved 2022-04-12. v t e v t e (Pages using ...

https://en.wikipedia.org/wiki/5_July_2015_Nigeria_attacks

BBC (16 January 2013). "Syria crisis: Dozens killed by Aleppo university blasts". BBC. Retrieved 21 January 2013. Lamine Chikhi ... "Blasts in Pakistan Kill at Least 115 and Raise Fears Over Elections". The New York Times. 10 January 2013. Retrieved 11 January ... "Shia mosque blast kills 15 in Pakistan". Times of India. Retrieved 21 June 2013. Alissa J. Rubin (24 June 2013). "Taliban ... "Quetta: Alamdar Rd blasts toll hits 84". The News International. 11 January 2013. Archived from the original on 11 January 2013 ...

https://en.wikipedia.org/wiki/List_of_terrorist_incidents_in_2013

"Nigeria's Boko Haram crisis: Jos blasts kill scores". BBC News. 6 July 2015. Retrieved 6 July 2015. "Scores killed in Nigeria ... The blast killed twelve people and wounded another one. The attack occurred at dawn and was attributed to Boko Haram although ... The blast killed at least 11 people. The attack occurred on 29 January in Gombi, Adamawa State. 30 January - At least 86 people ... "New Year's Day blast kills at least 3 in Nigeria". Xinhua News Agency. 2 January 2018. Archived from the original on January 2 ...

https://en.wikipedia.org/wiki/Timeline_of_the_Boko_Haram_insurgency

"Nigeria's Boko Haram crisis: Maiduguri blasts kill dozens". BBC. 21 September 2015. Retrieved 23 September 2015. Idowu, Kayode ... "Boko Haram crisis: Nigeria fury over U.S. arms refusal". BBC News. 11 November 2014. Retrieved 12 November 2014. Eric Schmidt ( ... "Boko Haram crisis: Nigeria estimates Baga deaths at 150". BBC News. 12 January 2015. Samer Muscati (10 June 2015). "Anatomy of ... Nigeria's Boko Haram Crisis explained. In: African Security Review 19/2, 2010, pp. 54-67. Marc-Antoine Pérouse de Montclos (ed ...

https://en.wikipedia.org/wiki/Boko_Haram

"Syria crisis: Dozens killed by Aleppo university blasts". BBC. Retrieved 15 January 2013. World Guide to Libraries (25 ed.), De ... The blasts reportedly struck an area between Aleppo University's halls of residence and the architecture faculty. The initial ...

https://en.wikipedia.org/wiki/University_of_Aleppo

"Syria crisis: Dozens killed by Aleppo university blasts". BBC News. 2013-01-15. Archived from the original on 2017-10-18. ... The blast struck a parking lot for a military intelligence complex. The 18 July 2012 Damascus bombing was an attack that killed ... April 29 - A blast next to former Interior Ministry building in Damascus killed six people. Syrian prime minister Wael al-Halqi ... "IS blasts kill more than 140 as US, Russia press Syria truce". Agence France-Presse, Yahoo News. 21 February 2016. Archived ...

https://en.wikipedia.org/wiki/List_of_terrorist_incidents_in_Syria

"Nigeria's Boko Haram crisis: Maiduguri blasts kill dozens". BBC News. September 21, 2015. Retrieved September 21, 2015. ... "Dozens die in blasts in Borno state capital, Nigerian official says". Abuja, Nigeria: CBS News. Associated Press. September 22 ... "5 suicide blasts hit Nigerian city of Maiduguri, 54 killed". Yahoo News. March 7, 2015. Bukar Hussain (September 21, 2015). "85 ... Lanre Ola; Isaac Abrak; Alexis Akwagyiram & Julia Payne (September 22, 2015). "At least 80 people killed in bomb blasts in ...

https://en.wikipedia.org/wiki/September_2015_Borno_State_bombings

"As Global Food Crisis Looms, Groups Blast Proposed $1.65 Billion USDA Cut". Common Dreams. Retrieved 7 April 2022. "Stepping Up ... The compounding crises in distinct parts of the world were caused by compounding geopolitical and economic crisis. The crises ... "Energy crisis today - fertiliser and food crisis tomorrow?". Euractiv. 19 October 2021. "'I'm afraid we're going to have a food ... fertiliser and food crisis tomorrow?". Euractiv. 19 October 2021. "'I'm afraid we're going to have a food crisis': The energy ...

https://en.wikipedia.org/wiki/2022_food_crises

MacKinnon, Mark (16 August 2020). "Leaders fear crisis sparked by Beirut blast could lead to civil war". The Globe and Mail Inc ... Economic Collapse, Energy Crisis, Now Fear of Civil War In Lebanon, 10/14/21 Newsweek Vohra, Anchal. "Sectarian Violence is ... "Deadly blast near Hezbollah complex in Beirut". Al Jazeera. Retrieved 15 August 2013. Karam, Zeina (15 August 2013). "Car bomb ... Grain freights arrived to Beirut on 19 November 1914 to the relief of the masses; however, the crisis was to worsen as both ...

https://en.wikipedia.org/wiki/History_of_Beirut

It is highly expressed in blast crisis transition of chronic myeloid leukemia. When overexpressed by transfection, NME3 ...

https://en.wikipedia.org/wiki/NME4

The disaster was reportedly exacerbated by the ongoing Lebanese liquidity crisis; in which the Lebanese pound has plummeted and ... at least 28 killed in fuel tanker blast in Akkar, Gareth Browne, Elias Sakr, August 15, 2021, Lebanon rages after deadly fuel ...

https://en.wikipedia.org/wiki/2021_Akkar_explosion

"Report: Interior official blasted for twisting environmental data". USA Today. March 30, 2007. Pegg, JR (29 November 2007). "U. ... "theory in crisis" with scientists criticizing evolution and that "fairness" and "equal time" requires educating students about ... of Americans say oil firms are to blame for the climate crisis". The Guardian. Archived from the original on 26 October 2021. ...

https://en.wikipedia.org/wiki/Politicization_of_science

Shrewsbury faced a further crisis in 1651, when governor Mackworth had to face down a demand that he surrender the town to ... Fisher's sermon was probably intended as a counter-blast to this Laudian triumphalism. He attacked the enforced conformity to ... The general atmosphere of crisis was then greatly intensified by an outbreak of bubonic plague at Frankwell in June, which soon ...

https://en.wikipedia.org/wiki/Samuel_Fisher_(died_1681)

Naylor, Hugh, and Andrew Roth, "NATO faces new Mideast crisis after downing of Russian jet by Turkey," washingtonpost.com, 24 ... The following day, Pennsylvania State Police troopers fire about 100 shotgun blasts at the aerostat to deflate it. 29 October ... Sly, Liz, "Russian airstrikes force a halt to aid in Syria, triggering a new crisis," washingtonpost.com, 14 December 2015, 7: ... Anonymous, "Kurdish rebels claim responsibility for deadly Istanbul airport blast," theguardian.com, 26 December 2015, 23:24 ...

https://en.wikipedia.org/wiki/2015_in_aviation

Instead, he relies on heroes like the Avatar to go forth and correct the various crises that crop up in Britannia. In Ultima IX ... and standing clear of the blasts was sufficient to kill him; or (d) using a pickpocket spell to steal the wand Lord British ...

https://en.wikipedia.org/wiki/Lord_British

Antiwar critics blasted them. These selfish special interests were too powerful, especially, Senator La Follette noted, in the ... The Crisis, vol. 18, no. 2 (June 1919), pp. 63-87. Epstein, Katherine C. "The Conundrum of American Power in the Age of World ...

https://en.wikipedia.org/wiki/United_States_in_World_War_I

He joins Gertrude Aldridge in trying to attack Erin, but they get knocked back by a proton shotgun blast, which caused him to ... causing a supernatural crisis throughout the city that later labeled as the "Vigo Incident of '89". Janosz chooses Oscar, in ... She later attempts to attack Erin again with "Sparky", but they end up getting knocked back by a proton shotgun blast. The ... is apparently open-minded on the paranormal and thus quietly and reluctantly supports them when facing supernatural crisis. By ...

https://en.wikipedia.org/wiki/List_of_Ghostbusters_characters

The blast buried Wilson and his daughter, Marie, in rubble. Unable to move, he held her hand and comforted her as she lay dying ... cit, p. 120 "Spirit of Enniskillen Trust charity folding due to pension crisis". BBC News. 15 March 2013. Retrieved 28 March ...

https://en.wikipedia.org/wiki/Gordon_Wilson_(peace_campaigner)

Petersburg, Florida, p. 7, October 24, 1968 "Humphrey Blasts Peace Move Talk", The Spokesman-Review, Spokane, Washington, p. 3 ... do nothing attitude toward the crime crisis in America." While campaigning in San Antonio, Humphrey went on the attack against ... the best interests of the nation to mix the partisan politics of a presidential election with the ongoing Vietnam crisis. ...

https://en.wikipedia.org/wiki/Hubert_Humphrey_1968_presidential_campaign

After a hole was blasted in the prison wall, the 41 Irgun and Lehi members who had been chosen to escape then ran to the hole, ... "Wrestling With Zion: Re-thinking Jewish Tradition and the Ongoing Crisis in the Middle East". www.acjna.org. Spring 2004. ... "Irgun's Hand Seen in Alps Rail Blast. Polish Jew Confesses He Was Lookout for Others Who Bombed British Train". The New York ... Irgun's Hand Seen in Alps Rail Blast. New York Times. August 16, 1947. W. Khalidi, 1971, 'From Haven to Conquest', p. 598 Terry ...

https://en.wikipedia.org/wiki/Irgun

He blasts away using his jetpack, promising they will meet again. The heroes head back to the Rebel base aboard the Falcon. ... Tyrant's Test (1996), the third book of Michael P. Kube-McDowell's Black Fleet Crisis trilogy features Lumpy and his rites of ... Taylor, Chris (September 27, 2014). "'Star Wars' Producer Blasts 'Star Wars' Myths". Mashable.com. Retrieved December 6, 2019. ...

https://en.wikipedia.org/wiki/Star_Wars_Holiday_Special

"White House blasts press over stories on Kobach election panel data request". WOKV. July 5, 2017. Archived from the original on ... "Trump Declares Opioid Crisis National Emergency". NBC News. August 10, 2017. Archived from the original on August 11, 2017. " ... "Trump does not rule out military response to Venezuela crisis". BBC. August 12, 2017. Archived from the original on August 12, ... "Trump signs Russia sanctions bill he blasts as 'clearly unconstitutional'". ABC News. August 2, 2017. Archived from the ...

https://en.wikipedia.org/wiki/Timeline_of_the_Donald_Trump_presidency_(2017_Q3)

... a fourth blast struck the headquarters of the Moderate Movement list, injuring two people, a fifth blast struck a building used ... What Do We Know About The Election Crisis in Iraq?, Radio Free Europe/Radio Liberty, 28 January 2010 Saleh al Mutlaq: Decision ... 26 February four civilians were injured as a massive blast struck Iraq's finance ministry.[citation needed] A car bomb targeted ...

https://en.wikipedia.org/wiki/2010_Iraqi_parliamentary_election

Hawkgirl felt that she wasn't the first person Hawkman would turn to in a moment of crisis, treating her as a damsel in ... and unleashes a blast of white light that turns Hawkman and Hawkgirl into white dust, while Deadman looks in horror. Deadman ... Hawkman and Hawkgirl watch as their world starts collapsing due to the Crisis, but they also realize that there might be a new ... Hawkgirl then left the Justice League due to injuries sustained in Final Crisis. In Blackest Night #1, Kendra is shown having ...

https://en.wikipedia.org/wiki/Hawkgirl_(Kendra_Saunders)

Crisis Group did not specify if "PKK-related" deaths are linked to Syria's YPG and SDF, or from Turkey or Iraqi PKK. Recent ... "Leading Democrats blast Trump over 'sham ceasefire' in Syria". Times of Israel. Kennedy, Merrit (17 October 2019). "Pence Says ... According to a Crisis Group death toll analysis based upon Turkey government and Turkish media publications, the border regions ... Crisis Group (16 October 2019), Turkey's PKK Conflict: A Visual Explainer, Fatalities map Kingsley, Patrick (16 October 2019 ...

https://en.wikipedia.org/wiki/2019_Turkish_offensive_into_north-eastern_Syria

"A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises ... However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B ...

https://en.wikipedia.org/wiki/CD34

... '03 was delayed until the crisis passed and took place on September 6. The show was billed as "The Last Bash in Barrie ... Music portal Canada portal List of festivals in Canada Music of Canada Sunfest (Gimli, Manitoba) "Edgefest 2003: A Blast From ...

https://en.wikipedia.org/wiki/Edgefest

Half mile long tunnels were drilled into the center of the mountain and were curved gently to reduce effects of a blast. ... ... in a crisis, and as a result the two services were, from a practical standpoint, poles apart on the issue of single control of ... and interconnecting communications-the Raven Rock bunker was hardened further to about 140 psi blast resistance by 1963: 315 ...

https://en.wikipedia.org/wiki/Raven_Rock_Mountain_Complex

"Funimation Announces English Casts for Saiyuki Reload Blast, Knight's & Magic, My First Girlfriend Is A Gal". Anime News ... Cross, Katherine (November 9, 2015). "How Cibele taught me to love existential sex crises". Gamasutra. Archived from the ...

https://en.wikipedia.org/wiki/Justin_Briner

... "a quarter-life crisis" with "women and excess, getting into trouble, pouring too much Jamison's into the ol' noggin, a lot of ... breezy sweetness that makes blasts of pure blissful oxygen like 'Someday's Gone' and 'Beekeeper's Daughter' extra satisfying, ...

https://en.wikipedia.org/wiki/Kids_in_the_Street

Nathan will mention if the player decides to wait for certain characters to leave the blast radius, and which building the ... Cold War Crisis, the first game in the Arma series. Malden's overhaul was originally developed for the now-defunct free-to-play ... a set of plans detailing how clandestine methods such as the Eastwind Device can be used to manufacture crises and make target ...

https://en.wikipedia.org/wiki/Arma_3

... during the global financial crisis and on The View on February 4, 2009, after the launch of his first book on the crisis. ... "Deadly blast targets Marriott Hotel in Islamabad - CNN.com". Edition.cnn.com. September 21, 2008. Archived from the original on ... During the financial crisis of 2007-2008, Velshi again appeared on television frequently throughout the day on shows like ... His first book, Gimme My Money Back: Your Guide to Beating the Financial Crisis, was published on January 2, 2009. His second ...

https://en.wikipedia.org/wiki/Ali_Velshi

Stormont in Crisis, a memoir (1994) "The BBC at the Watershed" (2008) Northern Ireland Civil Service Royal Belfast Academical ... neither Bloomfield nor his wife were injured in the blast. Having joined the Civil Service in 1952, Bloomfield was appointed ...

https://en.wikipedia.org/wiki/Kenneth_Bloomfield

... prior to the blast, a U.S. Atomic Energy Commission employee placed a humorous sign near the instruments over the blast site, ... As the Congo Crisis deepened, Christophe Gbenye offered to negotiate for the safe passage of white settlers (60 Americans and ... The shock wave from the blast "lifted the ground 4 inches in a ripple that rolled across the countryside for miles"; ... "Salt Dome A-Blast Lifts Earth Crust", Chicago Tribune, October 23, 1964, p1 Guardian archive: "Nobel Prize refused by Sartre". ...

https://en.wikipedia.org/wiki/October_1964

Originally a faceless medic, he's a soldier of MSF who fell into a coma after taking a blast meant for Big Boss. During the ... but was sent back to the USSR as a secret addition to the negotiations for ending the Cuban Missile Crisis. He develops the ... But..." / Ocelot: "Nine years ago in that helicopter, he threw himself between you and the blast. In that moment, the man you ... the Red Army personnel were assigned to build the base as an alternate strategic missile site after the Cuban Missile Crisis; ...

https://en.wikipedia.org/wiki/List_of_Metal_Gear_characters

"Sir Ken Blasts Morrisons CEO, Chairman and the board of directors". The Independent. 6 June 2014. Retrieved 6 June 2014. " ... You really can't communicate too much in a crisis'". Financial Times. 16 May 2021. Retrieved 1 June 2022. "God at work". ... At Morrisons annual AGM in June 2014, Morrisons former chairman Sir Ken Morrison blasted Phillips and his new board of ...

https://en.wikipedia.org/wiki/Dalton_Philips

The crisis resolved, Jason handed his duties as the League's magic expert over to Manitou Raven, newly arrived in the present, ... Other powers include mystically enhanced fangs and claws, enhanced senses, super speed, agility, telepathy, energy blasts, and ... A sketch of an alternate version of Etrigan called "Superdemon" was featured in Final Crisis: Secret Files #1. Described as a ...

https://en.wikipedia.org/wiki/Etrigan_the_Demon

One plaintiff, Vivian Elliott, won $1.5 million in 1994 when it was discovered that a family crisis center for which she had ... Tilton returned to television in 1994 with a new program called Pastor Tilton, a show with an emphasis on "demon blasting" ... quoted in Christianity in Crisis by Hank Hanegraaff, Harvest House Publishers, 1993, p. 348. "A Myth Shattered: New Report ... quoted in Christianity In Crisis by Hank Hanegraaff, Harvest House Publishers, 1993, p. 347. SacrifyX (June 3, 2014), Robert ...

https://en.wikipedia.org/wiki/Robert_Tilton

Hjelmgaard, Kim (12 January 2018). "U.N., African countries blast Trump's 'racist' words in angry global backlash". USA TODAY. ... Margesson, Rhonda; Taft-Morales (February 2, 2010). "Haiti Earthquake: Crisis and Response" (PDF). CRS Reports for Congress. ... of Haiti Jovenel Moïse at the Haiti National Palace about ways to implement a consensual resolution of Haiti's political crisis ...

https://en.wikipedia.org/wiki/Haiti–United_States_relations

Peter Lalor (6 November 2014). "Sachin Tendulkar blasts Michael Clarke, Ricky Ponting over Monkeygate". The Australian. ... In this hour of crisis, the board should stand by him". Tendulkar has reportedly denied sending an SMS to Sharad Pawar. Both ...

https://en.wikipedia.org/wiki/Second_Test,_2007–08_Border–Gavaskar_Trophy

... Corey Lorinsky ...

https://www.businessinsider.com/2008/8/how-to-solve-energy-crisis-blast-from-past-when-politicians-had-balls

67 Labour MPs blast Corbyn over anti-Semitism crisis 67 Labour MPs blast Corbyn over anti-Semitism crisis One third of all ...

https://www.israelnationalnews.com/news/266101

... myeloid blast crisis (MBC, n = 19), and lymphoid blast crisis (LBC, n = 20), we found 25 focal gene deletions and 14 fusions in ... Blast crisis of chronic myeloid leukemia is associated with poor survival and the accumulation of genomic lesions. Using whole- ... myeloid blast crisis (MBC, n = 19), and lymphoid blast crisis (LBC, n = 20), we found 25 focal gene deletions and 14 fusions in ... 2: The V(D)J recombination pathway is upregulated at lymphoid blast crisis.. ...

https://www.nature.com/articles/s41375-020-0751-y?error=cookies_not_supported&code=a07a90bb-5e08-46f6-8390-8648f66729c1

Former President Donald Trump blasted President Bidens handling of the border crisis, saying the country is being destroyed ... Trump blasts Bidens handling of border crisis: Our country is being destroyed. The Biden administration has struggled to ... Former President Donald Trump blasted President Bidens handling of the border crisis, saying the country is being "destroyed" ... Texas Governor: Biden border crisis a self inflicted wound. Gov. Abbott joins America Reports live from the Southern border ...

https://www.foxnews.com/politics/trump-biden-border-crisis-immigration-surge

A Blast from the Past: Are the Robo-Signing Issues that Plagued the Mortgage Crisis Set to Engulf the Student Loan Industry?. ... Hopkins, Jamie and Pustizzi, Katherine, A Blast from the Past: Are the Robo-Signing Issues that Plagued the Mortgage Crisis Set ... Financial Crises eJournal. Subscribe to this fee journal for more curated articles on this topic ...

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2413848

UKRAINE-CRISIS/MINE-BLAST - RTX6T8NZ A view shows a coal mine following a methane explosion near Luhansk A view shows the coal ...

https://pictures.reuters.com/archive/UKRAINE-CRISIS-MINE-BLAST-UP1EF4Q0MW91A.html

It is usually characterized by ≥30% blasts in the bone marrow or peripheral blood or development of ext... ... A blast crisis or lymphoid blast crisis refers to the transition of chronic or accelerated phase chronic myeloid leukemia to ... A blast crisis or lymphoid blast crisis refers to the transition of chronic or accelerated phase chronic myeloid leukemia to ... Lymphoid Blast Crisis of Chronic Myeloid Leukaemia is Associated with Distinct Clinicohaematological Features. Br J Haematol. ...

https://radiopaedia.org/articles/blast-crisis?lang=us

Crisis point: Mark Levy blasts leaders as COVID runs out of control. ... "The testing situation is a debacle and its reached crisis point in the state of NSW," he said. ...

https://www.2gb.com/crisis-point-mark-levy-blasts-leaders-as-covid-runs-out-of-control/

COVID-19, the economic crisis, and the Beirut blast: what 2020 meant to the Lebanese health-care system ... Citation: Mjaess G; Karam A; Chebel R; Tayeh GA; Aoun F. COVID-19, the economic crisis, and the Beirut blast: what 2020 meant ... 8. Abouzeid M, Habib RR, Jabbour S, Mokdad AH, Nuwayhid I. Lebanons humanitarian crisis escalates after the Beirut blast. ... The economic crisis. Lebanon is facing its worst economic crisis since the civil war. This was accompanied by a subsequent ...

http://www.emro.who.int/fr/emhj-volume-27-2021/volume-27-issue-6/covid-19-the-economic-crisis-and-the-beirut-blast-what-2020-meant-to-the-lebanese-health-care-system.html

A Kerry TD has accused the Health Minister of having no interest in the crisis at University Hospital Kerry.Independent TD ... Kerry TD blasts Health Minister for crisis at UHK. Jul 7, 2022 08:07 By radiokerrynews Photo: Kerry County Council. Share this ... A Kerry TD has accused the Health Minister of having no interest in the crisis at University Hospital Kerry. ... words of Independent TD Michael Healy-Rae when Health Minister Stephen Donnelly failed to show up for questions on the crisis ...

https://www.radiokerry.ie/news/kerry-td-blasts-health-minister-for-crisis-at-uhk-288704

Blast cri-sis. Tran-si-tio-nal pha-se from chro-nic to acu-te leukemia ...

https://www.zkrd.de/glossarliste/blast-crisis/?lang=en

Governor Abbott Blasts Mayor Bowser For Whining About Illegal Alien Crisis Coming To D.C. From Texas. By Ryan Saavedra ... The Daily Wire , Read , Governor Abbott Blasts Mayor Bowser For Whining About Illegal Alien Crisis Coming To D.C. From Texas ... Bowser said in her letter that she expects the "crisis" in D.C., a term that Democrats have resisted using when talking about ... Abbott responded on Twitter, writing: "D.C. is experiencing a fraction of the disastrous impact the border crisis has caused ...

https://www.dailywire.com/news/governor-abbott-blasts-mayor-bowser-for-whining-about-illegal-alien-crisis-coming-to-d-c-from-texas

Blast. , 10% blasts in blood or bone marrow samples. 10% - 20% blasts in blood or bone marrow samples. High blood basophil ... 10% will progress to accelerated and then ultimately blast phase.. *The median survival of patients with blast crisis without ... Blast Crisis: A critical increase in circulating leukocytes, or leukostasis, leads to blood hyperviscosity and ultimately ... The most common cause of death in patients in blast crisis is infection secondary to functional neutropenia, followed by fatal ...

http://www.emdocs.net/core-em-emergency-management-of-blast-crisis/

Observations on blast crisis in chronic myeloid leukaemia. Journal of the Indian Medical Association. 1965 Nov; 45(10): 525-32 ...

https://imsear.searo.who.int/handle/123456789/102568

What Is CML Blast Crisis?. You move into the blast phase when blast cells, another type of white blood cell, make up more than ... Leukemia and Lymphoma Society: "Accelerated Phase and Blast Crisis Phase Treatment.". National Cancer Institute: "General ... Treating Accelerated or Blast Phases. If youre in a later phase of CML, your treatment tries to reduce the number of cells ...

https://www.webmd.com/cancer/lymphoma/features/cml-chronic-phase-tips

Blast crisis. The chronic phase can last for months or years. The disease may have few or no symptoms during this time. Most ... The blast crisis phase is very difficult to treat. This is because there is a very high count of immature white blood cells ( ... Blast crisis can lead to complications, including infection, bleeding, fatigue, unexplained fever, and kidney problems. ... Untreated CML leads to the blast crisis phase. Bleeding and infection may occur due to bone marrow failure. ...

https://medlineplus.gov/ency/article/000570.htm

Binghamton residents blast plan for neighborhood crisis center By Bernadette A. Demartini On Jul 14, 2022. ... Grassi said "you dont put a crisis center in the middle of a quiet residential neighborhood." He said if the facility is built ... Residents of a quiet Binghamton neighborhood are expressing outrage at an agencys plan to build a 20-unit crisis center near ...

https://chattahoocheetrace.com/binghamton-residents-blast-plan-for-neighborhood-crisis-center/

Immunophenotypic characteristics of blast crisis of chronic myeloid leukaemia: correlations with clínico-biological features ... Immunophenotypic characteristics of blast crisis of chronic myeloid leukaemia: correlations with clínico-biological features ... Immunophenotypic characteristics of blast crisis of chronic myeloid leukaemia: correlations with clínico-biological features ... Immunophenotypic characteristics of blast crisis of chronic myeloid leukaemia: correlations with clínico-biological features ...

https://portalrecerca.uab.cat/en/publications/immunophenotypic-characteristics-of-blast-crisis-of-chronic-myelo

After the blast, the centre changed its name from Mawoud to Kaj and resumed educating underprivileged Hazara children. ... She said there were no ambulances at the scene following the blast. "Mangled bodies were taken to a nearby mosque, and other ... rushed to the blast site, desperately praying his sister was safe. ...

https://globalcrisisnews.com/breaking/my-sister-had-dreams-mourning-after-school-blast-in-kabul/

One year after the Beirut blast Lebanon is facing a deep crisis. Страны. Ливан. Источники. ACT Alliance. Дата публикации. 5 ... Lebanese people are facing intersecting and multiple crises: the Syrian refugee influx crisis, widespread street uprises, the ... All these crises are putting Lebanon on the edge of collapse.. Despite a decade-long rate of 1,507.5 LBP to the dollar, the ... Also, the pharmaceutical crisis has deepened in Lebanon as the central bank is unable to meet the cost of subsidised medicines. ...

https://m.reliefweb.int/report/3762352/lebanon/one-year-after-beirut-blast-lebanon-facing-deep-crisis?lang=ru

Former President Mahama has denied claims by the IMF boss that Ghanas current economic crisis is as a result of external ... Economic Crisis: Mahama Blasts IMF Boss Over Comments Attributing It To External Shocks And Not Bad Policies. Thursday, ... Former President Mahama has descended on the IMF boss, Kristalina Georgieva, over comments that Ghanas economic crisis should ... Mr Mahamas criticism of the IMF boss follows her statement attributing Ghanas current economic crisis to external influences ...

https://yen.com.gh/politics/215717-economic-crisis-mahama-blasts-imf-boss-comments-attributing-external-shocks-bad-policies/

COVID-19, the economic crisis, and the Beirut blast: what 2020 meant to the Lebanese health-care system Georges Mjaess; Aya ...

https://apps.who.int/iris/discover?field=author&filtertype_0=mesh&filter_relational_operator_0=contains&filter_0=COVID-19&filtertype=author&filter_relational_operator=equals&filter=Georges+Mjaess

Hypocrites and greenwash: Greta Thunberg blasts leaders over climate crisis. 9 Nov 2020. ... oil and gas companies under a non-renewable energy category that effectively puts them on the wrong side of climate crisis. ...

https://www.theguardian.com/environment/2019/jul/05/biggest-compliment-yet-greta-thunberg-welcomes-oil-chiefs-greatest-threat-label

PDP crisis deepens as Rivers state governor blasts party Chairman. By TV360 NigeriaSep 06, 2022, 09:58 am0 ... Home TV360 Reports PDP crisis deepens as Rivers state governor blasts party Chairman ...

https://www.tv360nigeria.com/pdp-crisis-deepens-as-rivers-state-governor-blasts-party-chairman/

Turkish coal mine blast leaves 40 dead, many trapped: officials October 15, 2022 ...

http://foxbreaking-news.com/sean-duffy-blasts-biden-on-border-crisis-he-wants-chaos/

The death toll from this months Beirut port blast has risen to 190 with more than 6,500 injured and three people missing, ... a day before French President Emmanuel Macron visits to press leaders to act to save the country from a deep financial crisis ... BEIRUT (Reuters) - The death toll from this months Beirut port blast has risen to 190 with more than 6,500 injured and three ... The outgoing government quit over the blast.. The presidency will talk to parliamentary blocs on Monday to designate a new ...

https://www.reuters.com/article/us-lebanon-crisis-blast-casualties/beirut-port-blast-death-toll-rises-to-190-idUSKBN25Q08H

Pallone Blasts GOP Plan to Address Energy and Climate Crises. Jun 2, 2022 Press Release ...

https://energycommerce.house.gov/subcommittees/energy-117th-congress?page=3

HomePoliticsPDP crisis: Wike blasts BoT for asking Iyorchia Ayu to resign after 2023 polls. PDP crisis: Wike blasts BoT for ...

https://www.sagagist.com.ng/2022/10/pdp-crisis-wike-blasts-bot-for-asking.html

Hawkins campaign blasts Democrats manufactured crisis in Wisconsin. SYRACUSE, NY - Today the Wisconsin Supreme Court ordered ... address the climate crisis and clean up the environment, support families and businesses during the economic collapse, prevent ...

https://www.gp.org/tags/voter_suppression?page=9

President Giammattei himself has openly criticized the Biden administration during an English-language interview on Sunday, saying that they are principally to blame for the current crisis at their own border . (thepostmillennial.com)
Critics who blasted Harris' visit included Republican members of the Wisconsin State Assembly Reps. Jim Steineke and Tyler August, who recently visited the southern border and experienced the Biden administration's disastrous handling of the crisis firsthand. (wispolitics.com)
Happy to have her visit Milwaukee, but she really ought to inspect the crisis President Biden created at the border. (wispolitics.com)
He declared that Biden has blood "on his hands" as the southern border crisis continues. (bigleaguepolitics.com)
The congressman made an appearance on "The Faulkner Focus" where he put the Biden administration on blast. (bigleaguepolitics.com)
Former Fox News host Bill O'Reilly blasted Democrats during a segment on Sean Hannity's nationally syndicated radio program Wednesday, noting correctly that a vote for presumptive party nominee Joe Biden is akin to casting a ballot for billionaire socialist George Soros and "open borders. (bizpacreview.com)
A top oil industry expert is blasting Joe Biden and his Democratic Party for warring against the fossil fuel industry and pushing insane 'wind' and 'solar' power as well as expensive and imperfect electric vehicles , even as he warned that a "major crisis" is coming in a few weeks. (traitors.news)

You mustn't procure permission to access "http://www.indiatoday.in/world/myth/sri-lanka-pm-wickremesinghe-economic-crisis-address-gas-shortage-airline-sale-debt-budget-1950191-2022-05-16? (shimlatimes.in)

You move into the blast phase when blast cells, another type of white blood cell, make up more than 20% of your blood or bone marrow (the place in your bone where blood cells are made). (webmd.com)

Bowser said in her letter that she expects the "crisis" in D.C., a term that Democrats have resisted using when talking about Biden's border crisis, "to escalate. (dailywire.com)
And of course the Democrats snuck amnesty into the bill: Illegal immigrants in "essential services" would be authorized to work for the duration of the crisis. (bizpacreview.com)

Former President Donald Trump blasted President Biden's handling of the border crisis, saying the country is being "destroyed" by the recent surge of illegal migrants at the border. (foxnews.com)
The exchange comes as critics and many experts have said that Democrat President Joe Biden's policies have led to the unprecedented border crisis that has seen hundreds of thousands of illegal aliens flood southern border states for the overwhelming majority of Biden's presidency. (dailywire.com)

Using whole-exome and/or RNA sequencing of patients at chronic phase (CP, n = 49), myeloid blast crisis (MBC, n = 19), and lymphoid blast crisis (LBC, n = 20), we found 25 focal gene deletions and 14 fusions in 24 patients in BC. (nature.com)
Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. (nature.com)
A blast crisis or lymphoid blast crisis refers to the transition of chronic or accelerated phase chronic myeloid leukemia to acute leukemia . (radiopaedia.org)
10% will progress to accelerated and then ultimately blast phase. (emdocs.net)
Untreated CML leads to the blast crisis phase. (medlineplus.gov)
The blast crisis phase is very difficult to treat. (medlineplus.gov)
Transplant may also be recommended for people who are diagnosed in accelerated phase or blast crisis. (medlineplus.gov)
This phase is characterized by poor control of blood counts with myelosuppressive medication and the appearance of peripheral blast cells (≥15%), promyelocytes (≥30%), basophils (≥20%), and platelet counts less than 100,000 cells/μL unrelated to therapy. (medscape.com)
Samples were collected for mutation analysis from patients who exhibited tyrosine kinase inhibitor resistance following treatment or were in the accelerated or blast phase at diagnosis. (spandidos-publications.com)
Dasatinib (Sprycel): Indicated for the treatment of adult patients with chronic myeloid leukemia in chronic, accelerated, or myeloid or lymphoid blast phase who are resistant or intolerant to prior therapy including imatinib. (medscape.com)
Without treatment, CML typically progresses over three to five years from the initial phase through a transition (accelerated) phase to a rapidly fatal form called blast crisis(1). (novartis.com)
Once patients reached the final blast crisis phase, survival was generally three to six months(3). (novartis.com)
Considered ineffective once in blast crisis phase. (mims.com)
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by a three-phase clinical course comprising an initial chronic phase, an accelerated phase, and a blast phase. (medscape.com)
Treatment protocols for chronic myelogenous leukemia (CML) are provided below for chronic phase, accelerated phase, and blast phase. (medscape.com)
[ 6 ] Additionally, a follow-up study showed significant improvement in 8-year event survival, freedom from progression to accelerated phase or blast phase, and overall survival. (medscape.com)
1% at 12 months had inferior EFS and higher rate of progression to accelerated- or blast-phase CML, while those with an MMR ( BCR-ABL1 ≤ 0.1%) by 18 months had no progression to advanced disease and 95% EFS at 7 years. (medscape.com)

Fig. 1: Global transcriptomic shift at blast crisis towards myeloid or lymphoid lineage. (nature.com)

The clinical manifestations of CML are insidious, changing somewhat as the disease progresses through its 3 phases (chronic, accelerated, and blast). (medscape.com)

Lebanon suffered a hattrick of simultaneous events during 2020 - the economic crisis, the Beirut blast and the COVID-19 pandemic - which sorely tested its ability to orchestrate recovery efforts. (who.int)

The explosion came at a time when the country was and continues to grapple with the COVID-19 pandemic and the worst economic crisis ever experienced, with more than half the population living under the poverty line. (reliefweb.int)
Lebanese people are facing intersecting and multiple crises: the Syrian refugee influx crisis, widespread street uprises, the COVID-19 pandemic, a dangerous depletion of resources, and finally the Beirut Port Explosion that left the country in shock. (reliefweb.int)
The Republican and Democratic Party conventions showed that both major parties are failing to control the pandemic and protect people, address the climate crisis and clean up the environment, support families and businesses during the economic collapse, prevent police violence or deal with any of the other major problems we face. (gp.org)

Lebanon is facing its worst economic crisis since the civil war. (who.int)
In an attempt to put an end to the two-year-long presidential vacuum, spare Lebanon from regional crises and resume political life, Hariri and his political team came to accept Hezbollah's first candidate, Michel Aoun. (alarabiya.net)

The American people should be alarmed by the growing restrictions created by our government officials in response to the COVID-19 health crisis. (leavetheplantation.org)
He said the country's farmers had proven their mettle during the Covid-19 crisis. (indiatimes.com)

Ritata posted a water crisis distress message on 28 February 2021 on the Banaban Network Facebook page calling for urgent intervention for the sake of the survival of his people. (pina.com.fj)

Earlier this week, the London Stock Exchange reclassified oil and gas companies under a non-renewable energy category that effectively puts them on the wrong side of climate crisis. (theguardian.com)
I have been going to almost every protest held here in Pittsburgh, particularly the climate crisis strikes. (ruthekarlin.com)

The presidency will talk to parliamentary blocs on Monday to designate a new prime minister, a day before French President Emmanuel Macron visits to press leaders to act to save the country from a deep financial crisis rooted in endemic corruption and mismanagement. (reuters.com)
The First Minister Mark Drakeford has blasted Jacob Rees-Mogg for his "frankly implausible explanations" for why the UK is in financial crisis. (nation.cymru)
He said that the financial crisis was causing a "series of anxieties for us" in Wales. (nation.cymru)
The former chief executive, who led AIG out of the financial crisis, was 70. (ibtimes.com)

The bill contains an amnesty provision for the duration of the coronavirus crisis… All illegal immigrants employed in so-called essential services would be shielded from deportation. (bizpacreview.com)

Immunophenotypic and Genotypic Characteristics of Chronic Myelogenous Leukemia in Blast Crisis. (radiopaedia.org)

CDC's Crisis and Emergency Risk Communication (CERC) manual was first published in 2002 to provide an approach to health communication during emergencies based on experience and psychological and communication sciences. (cdc.gov)
In terms of the overall number of victims and its political impact, it fell far short of the largest and deadliest terrorist attacks in Russia over the past decade and a half, including the Budennovsk and Kyzliar terrorist raids in 1995-96, the 1999 apartment-building bombings in Moscow and other cities, several passenger aircraft bombings and the large-scale hostage crises in Moscow (2002) and Beslan (2004). (realinstitutoelcano.org)

Consequently, the peripheral blood cell profile shows an increased number of granulocytes and their immature precursors, including occasional blast cells. (medscape.com)

As a result of the ongoing energy crisis throughout Europe, Switzerland is considering a ban on the use of electric cars for non-essential purposes. (breitbart.com)
The Olaf Scholz government has mishandled "everything" during the energy crisis, resulting in economic calamity, a German MEP told Breitbart. (breitbart.com)
Germany's massive energy crisis is "under control", the country's Chancellor has insisted despite repeated warnings of possible blackouts occurring over the coming months. (breitbart.com)
Protesters gathered in front of a shuttered power station on Sunday to demonstrate against the Irish government's banning of a natural and abundant fossil fuel just in time for the winter energy crisis. (breitbart.com)
The plant was scheduled to shut down for good this fall, but due to the German energy crisis, it's one of several coal plants nationwide that will continue to burn coal to get the country through the winter. (tpr.org)
Germany's central bank recently predicted a clear, broad-based decline in the country's economic output mainly due to the energy crisis. (tpr.org)

Patients are often unable to afford medical services impacted by the economic crisis, with more than 40% of the Lebanese population now living below the poverty line, especially in underserved areas (5). (who.int)
Regardless of the cause, the blast was devastating for the Lebanese health-care system (7). (who.int)
What we see these days is repercussions of a crisis that goes back to the fact that the Lebanese crisis is deeply rooted in the structure of the regime itself. (alarabiya.net)

The violence comes just days after a deadly hostage crisis in which 28 people were killed, including 20 hostages, two police and six of the attackers. (tmj4.com)

BEIRUT (Reuters) - The death toll from this month's Beirut port blast has risen to 190 with more than 6,500 injured and three people missing, Lebanon's caretaker government said in a report dated Sunday. (reuters.com)

According to him, that assertion cannot be backed by facts since the reality on the ground indicates that the country's current economic crisis is a result of the bad economic policies of the Akufo-Addo-led government. (com.gh)

Discernment from the extremely close differential diagnosis of myeloid blast crisis CML is challenging, largely relying on medical history rather than clinical characteristics (Arber et al. (bvsalud.org)

Madison, WI] - Yesterday, Vice President Kamala Harris visited Milwaukee - the latest stop in her national tour designed to convey how little she cares about the crisis at our southern border. (wispolitics.com)
Kamala Harris should be visiting the southern border, given it has been nearly a month and a half since being tasked with managing the border crisis, and she still has not found time to address a problem that has spiraled out of control,' [Republican Party of Wisconsin Chairman] Hitt said in a statement. (wispolitics.com)
VP Kamala Harris went on a road trip - not to the southern border where she is presiding over a crisis - but to Wisconsin to tout the Administration's latest infrastructure plan. (wispolitics.com)

Kabbage's existing online lending platform was able to process the sudden flood of loan applications, in a timely manner, in the midst of a national crisis and in light of ever-changing federal lending rules," the company said. (bankingdive.com)

Blast crisis of chronic myeloid leukemia is associated with poor survival and the accumulation of genomic lesions. (nature.com)
Immunophenotypic characteristics of blast crisis of chronic myeloid leukaemia: correlations with clínico-biological features and survival. (uab.cat)

With pledges from Texas and Arizona to continue these abhorrent operations indefinitely, the situation is dire, and we consider this a humanitarian crisis - one that could overwhelm our social support network without immediate and sustained federal intervention," Bowser wrote in requesting help from the National Guard. (dailywire.com)
Renowned Southern Cameroons academic Professor Carlson Anyangwe says the deliberate silence on the part of the international community on the war in British Southern Cameroons is to blame for widespread humanitarian crisis. (cameroonintelligencereport.com)
Home Environment Severe drought and water crisis in Banaba, community elder call for humanitarian. (pina.com.fj)
The people of Banaba Island in Kiribati are calling for humanitarian intervention from Australia, New Zealand and the international community to an on-going severe drought and water crisis on the island. (pina.com.fj)

The extreme drought and water crisis have put Banaba in a desperate position that it has become a matter of life and death for everyone on the remote island amid the COVID19 times. (pina.com.fj)
Turkey, pork, and other Christmas day staples have all seen price spikes of around 20 per cent or more amid Britain's inflation crisis. (breitbart.com)

Former President Mahama has descended heavily on the Managing Director of the International Monetary Fund (IMF), Kristalina Georgieva, over comments that Ghana's economic crisis should be blamed on external shocks . (com.gh)
Mr Mahama's criticism of the IMF boss follows her statement attributing Ghana's current economic crisis to external influences and not bad policies. (com.gh)
The economic crisis is being used as a pretext for a renewed round of private property seizures reminiscent of the Yukos affairs, reports a front page article in the New York Times and International Herald Tribune . (robertamsterdam.com)
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This photomicrograph of a patient's peripheral blood sample, reveals histopathologic changes indicative of what is referred to as a blast crisis in a case of chronic myelogenous leukemia (CML). (cdc.gov)

The " overwhelming " number of migrants seen at the border had Department of Homeland Security (DHS) Secretary Alejandro Mayorkas ask for volunteers in his agency to help deal with the crisis. (foxnews.com)
Abbott responded on Twitter, writing: "D.C. is experiencing a fraction of the disastrous impact the border crisis has caused Texas. (dailywire.com)

Residents of a quiet Binghamton neighborhood are expressing outrage at an agency's plan to build a 20-unit crisis center near their home. (chattahoocheetrace.com)
Why plan crisis communication? (cdc.gov)

The World Health Organization (WHO) confirmed that the blast caused damage to more than half of Beirut's health infrastructure - three hospitals became non-functional, three were extensively damaged, 500 hospital bed equivalents were lost, and many primary care facilities destroyed (8) - limiting the health service functionality essential for the response and management of such a crisis (9). (who.int)
Clinton went on to blast the state government for its response to the crisis. (motherjones.com)
David Payne Purdum blasts betting giants over poor response to recent crisis. (gambling911.com)
The response to the tragic blast is being coordinated at the site by Deputy Prime Ministers Rumyana Bachvarova (also Interior Minister) and Tomislav Donchev, Transport Minister Ivaylo Moskovski, Health Minister Petar Moskov, Interior Ministry Chief Secretary Georgi Kostov, and fire brigade chief Nikolay Nikolov. (novinite.com)
It reviews some of the general flaws in public transport security and in the protection-centred measures undertaken in response to the blast. (realinstitutoelcano.org)

The New Statesman's weekly environment email on the politics, business and culture of the climate and nature crises - in your inbox every Thursday. (newstatesman.com)

A crisis committee, including several agencies, local officials and fire brigade staff, will be set up to inspect damages and provide urgent assistance to people who sustained injuries. (novinite.com)

Kabul, Afghanistan - As soon as he heard about the explosion at the Kaj education centre, Mukhtar Modabber, 30, rushed to the blast site, desperately praying his sister was safe. (globalcrisisnews.com)

Former French president Nicolas Sarkozy blasted what he said was a lack of evidence for the corruption charges against him over allegations that late Libyan dictator Moamer Kadhafi funded his 2007 election campaign, in his court statement published Thursday. (sabcnews.com)

According to the 68 year old community leader, the water crisis worsened when the island's two desalination plants broke down, forcing the people to resort to drinking 'polluted and dirty water' from the cave on the island. (pina.com.fj)

Australia is walking towards an extinction crisis a new report warns. (yahoo.com)

Most importantly, the crises disintegrated nation-states in the affected countries, which in turn made them a fertile ground for many terrorist organizations such ISIS. (alarabiya.net)
Less than a month before the airport blast, another unrelated group was planning a terrorist attack in downtown Moscow for the New Year holidays but the plot failed, as the explosive device reportedly detonated prematurely at what was still a preparatory stage on 31 December. (realinstitutoelcano.org)
Still, this latest blast in the long list of large-scale terrorist attacks in Russian urban areas and transport systems has demonstrated at least two new inter-related features. (realinstitutoelcano.org)
Such canines have played a very important role in thwarting numerous bomb blasts and terrorist conspiracies," Modi said. (indiatimes.com)

The patient had fever, erythematous rash, abdominal pain, and severe central nervous system involvement with convulsive crisis. (cdc.gov)

Anatomy16

Organisms1

Diseases22

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology1

Phenomena and Processes16

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Health Care2

Toward a leukemia treatment strategy based on the probability of stem cell death: an essay in honor of Dr. Emil J Freireich. (1/479)

Prognostic significance of bone marrow biopsy in essential thrombocythemia. (2/479)

Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. (3/479)

Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. (4/479)

Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. (5/479)

Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia. (6/479)

Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. (7/479)

Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance. (8/479)

Blast Crisis

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Fusion Proteins, bcr-abl

Leukemia, Myeloid

Benzamides

Crisis Intervention

Blast Injuries

Piperazines

Leukemia, Myeloid, Accelerated Phase

Pyrimidines

Philadelphia Chromosome

Chromosomes, Human, 21-22 and Y

Genes, abl

Leukemia, Myeloid, Chronic-Phase

Leukemia, Myeloid, Acute

Granulocyte-Macrophage Progenitor Cells

Gene Expression Regulation, Leukemic

Leukemia, Lymphoid

Thyroid Crisis

K562 Cells

Leukemia

Proto-Oncogene Proteins c-bcr

Anemia, Refractory, with Excess of Blasts

Bone Marrow

Karyotyping

Chromosomes, Human, Pair 22

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Neoplastic Stem Cells

Antineoplastic Agents

Blood Cell Count

Chromosomes, Human, Pair 9

Acute Disease

Drug Resistance, Neoplasm

Cytogenetic Analysis

Cytarabine

Economic Recession

Granulocytes

Chromosome Aberrations

Gene Rearrangement

Hematopoietic Stem Cells

Anemia, Sickle Cell

Remission Induction

Myelodysplastic Syndromes

Protein-Tyrosine Kinases

Antigens, CD34

RNA, Neoplasm

Nucleotidases

Translocation, Genetic

Bone Marrow Cells

Proto-Oncogene Proteins c-abl

Antigens, Surface

Myeloproliferative Disorders

Myeloid Progenitor Cells

Nucleoside Deaminases

Bone Marrow Transplantation

5'-Nucleotidase

Antigens, Neoplasm

Cell Transformation, Neoplastic

DNA, Neoplasm

Phenanthrenes

Blotting, Southern

Chromosomes, Human, Pair 3

Disease Progression

Cell Differentiation

Tumor Stem Cell Assay

Lymphocytes

Mutation

Tumor Cells, Cultured

Protein Kinase Inhibitors

Immunophenotyping

Adenosine Deaminase

Molecular Sequence Data

Proto-Oncogene Proteins

Oryza sativa

B-Lymphocytes

Explosions

Apoptosis

Base Sequence

Transplantation, Homologous

Recurrence

$Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Blast Phase Who Are Refractory to Imatinib Mesylate ...$ Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Blast Phase Who Are Refractory to Imatinib Mesylate ...