Blast Crisis: An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.Fusion Proteins, bcr-abl: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Benzamides: BENZOIC ACID amides.Crisis Intervention: Brief therapeutic approach which is ameliorative rather than curative of acute psychiatric emergencies. Used in contexts such as emergency rooms of psychiatric or general hospitals, or in the home or place of crisis occurrence, this treatment approach focuses on interpersonal and intrapsychic factors and environmental modification. (APA Thesaurus of Psychological Index Terms, 7th ed)Blast Injuries: Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)PiperazinesLeukemia, Myeloid, Accelerated Phase: The phase of chronic myeloid leukemia following the chronic phase (LEUKEMIA, MYELOID, CHRONIC-PHASE), where there are increased systemic symptoms, worsening cytopenias, and refractory LEUKOCYTOSIS.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Philadelphia Chromosome: An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).Chromosomes, Human, 21-22 and Y: The short, acrocentric human chromosomes, called group G in the human chromosome classification. This group consists of chromosome pairs 21 and 22 and the Y chromosome.Genes, abl: Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.Leukemia, Myeloid, Chronic-Phase: The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Granulocyte-Macrophage Progenitor Cells: The parent cells that give rise to both cells of the GRANULOCYTE lineage and cells of the monocyte/macrophage lineage.Gene Expression Regulation, Leukemic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.Leukemia, Lymphoid: Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.Thyroid Crisis: A dangerous life-threatening hypermetabolic condition characterized by high FEVER and dysfunction of the cardiovascular, the nervous, and the gastrointestinal systems.K562 Cells: An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Proto-Oncogene Proteins c-bcr: Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.Anemia, Refractory, with Excess of Blasts: Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Karyotyping: Mapping of the KARYOTYPE of a cell.Chromosomes, Human, Pair 22: A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Neoplastic Stem Cells: Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Chromosomes, Human, Pair 9: A specific pair of GROUP C CHROMSOMES of the human chromosome classification.Acute Disease: Disease having a short and relatively severe course.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Cytogenetic Analysis: Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Economic Recession: Significant decline in economic activity spread across the economy, lasting more than a few months, normally visible in real gross domestic product, real income, employment, industrial production, and wholesale-retail sales. (National Bureau of Economic Research, Inc, www.nber.org/cycles.html, accessed 4/23/2009)Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Gene Rearrangement: The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Protein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.RNA, Neoplasm: RNA present in neoplastic tissue.Nucleotidases: A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthophosphate. EC 3.1.3.-.Translocation, Genetic: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Proto-Oncogene Proteins c-abl: Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Myeloid Progenitor Cells: Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.Nucleoside Deaminases: Catalyze the hydrolysis of nucleosides with the elimination of ammonia.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.5'-Nucleotidase: A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.DNA, Neoplasm: DNA present in neoplastic tissue.PhenanthrenesBlotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Chromosomes, Human, Pair 3: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Tumor Stem Cell Assay: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.Adenosine Deaminase: An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Oryza sativa: Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.ExplosionsApoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Recurrence: The return of a sign, symptom, or disease after a remission.Manuals as Topic: Books designed to give factual information or instructions.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Thiazoles

Toward a leukemia treatment strategy based on the probability of stem cell death: an essay in honor of Dr. Emil J Freireich. (1/479)

Dr. Emil J Freireich is a pioneer in the rational treatment of cancer in general and leukemia in particular. This essay in his honor suggests that the cell kill concept of chemotherapy of acute myeloblastic leukemia be extended to include two additional ideas. The first concept is that leukemic blasts, like normal hemopoietic cells, are organized in hierarchies, headed by stem cells. In both normal and leukemic hemopoiesis, killing stem cells will destroy the system; furthermore, both normal and leukemic cells respond to regulators. It follows that acute myelogenous leukemia should be considered as a dependent neoplasm. The second concept is that cell/drug interaction should be considered as two phases. The first, or proximal phase, consists of the events that lead up to injury; the second, or distal phase, comprises the responses of the cell that contribute to either progression to apoptosis or recovery. Distal responses are described briefly. Regulated drug sensitivity is presented as an example of how distal responses might be used to improve treatment.  (+info)

Prognostic significance of bone marrow biopsy in essential thrombocythemia. (2/479)

BACKGROUND AND OBJECTIVE: The diagnostic and prognostic value of bone marrow biopsy (BMB) has been widely investigated in patients with chronic myeloproliferative disorders (CMPD). The present study is based on a review of the results of routine BMBs taken from 93 essential thrombocythemia (ET) patients at the time of diagnosis. DESIGN AND METHODS: The common BMB histologic parameters and clinico-hematologic variables were considered for diagnostic and prognostic purposes. Clinico-pathologic correlations were looked for univariately. Moreover, the diagnostic significance of the histologic findings was tested by means of cluster analysis. Overall survival and event-free survival were considered as prognostic endpoints. RESULTS: There were no correlations between the clinic and pathologic findings, and none of the histologic and clinical parameters was predictive of survival or the occurrence of major clinical events. Cluster analysis of the BMB findings revealed two distinct morphologic patterns: one was clearly myeloproliferative; the other had somewhat dysplastic features. The event-free and overall survival rates in the latter group were significantly worse (p = 0.0377 and p = 0.0162 respectively), with major ischemic events accounting for most of the difference in event-free survival. INTERPRETATION AND CONCLUSIONS: These results have no clearcut counterpart in the literature, but we feel that dysplastic BMB findings could be included in the definition of ET prognostic scores in order to allow therapeutic strategies to be adapted to the level of risk.  (+info)

Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. (3/479)

Studies in cell lines have indicated that expression of the BCL-2 family of proteins is an important determinant of chemotherapy-induced apoptosis; however, the level of expression of these proteins in childhood acute lymphoblastic leukemia (ALL) has not been extensively reported. Using quantitative Western blotting we have determined the level of expression of BCL-2, BAX, MCL-1, and BCL-X in lymphoblasts from 47 children with ALL (33 at presentation only, 4 at relapse only, and 10 at both presentation and on relapse). Results were determined as a ratio to actin as an internal control. BCL-2, BAX, and MCL-1 were detected in all samples. BCL-XL was only detected in 6 cases (4 at presentation and 2 at relapse) and BCL-XS in none. No correlation was found between expression and white blood cell count, age at diagnosis, gender, or blast karyotype. BCL-2 levels and the BCL/BAX and MCL-1/BAX ratios were found to be significantly higher in B-lineage as compared with T-lineage disease (P <.003,.02, and.02, respectively). No consistent pattern of change in expression was noted in the 10 cases studied at both presentation and relapse. Kaplan-Meier analysis showed a significant correlation between high BAX expression and an increased probability of relapse (P <.05 by the log rank test), suggesting that chemosensitivity in leukemic blasts may be regulated by factors that override the BCL-2 pathway.  (+info)

Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. (4/479)

The two matrix metalloproteinases (MMPs) Mr 72,000 type IV collagenase (MMP-2, gelatinase A) and Mr 92,000 type IV collagenase (MMP-9, gelatinase B) play key roles in tissue remodeling and tumor invasion by digestion of extracellular matrix barriers. We have investigated the production of these two enzymes as well as the membrane-type MMP (MT1-MMP) and the tissue inhibitors of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 in the bone marrow mononuclear cells (BM-MNCs) of patients with acute myeloid leukemia (AML; n = 24), chronic myeloid leukemia (CML; n = 17), myelodysplastic syndromes (MDS; n = 8), and healthy donors (n = 5). Zymographic analysis of BM-MNC-conditioned medium showed that a Mr 92,000 gelatinolytic activity, identified as MMP-9 by Western blotting, was constitutively released from cells of all patients and healthy individuals examined in this study. In contrast, MMP-2 secretion was found to be absent in all samples from healthy donors but present in 8 of 11 (73%) of the samples from patients with primary AML, 7 of 8 (88%) with secondary AML, and only 1 of 5 (20%) cases with AML in remission, indicating MMP-2 to be produced by the leukemic blasts. MMP-2 release was not detected in CML cell-conditioned medium with the exception of two cases, both patients either being in or preceding blast crisis. In MDS, MMP-2 was found in three of eight (38%) of the patients, two of them undergoing progression of disease within 12 months. Quantitative Northern blot analysis in freshly isolated BM-MNCs showed a relatively low constitutive expression of TIMP-1 in all samples, whereas MMP-9 gene transcription was higher in healthy donors and CML samples, than in AML and MDS. Reverse transcriptase-PCR analysis revealed the presence of TIMP-2 mRNA in the majority of MMP-2-releasing BM-MNCs. MT1-MMP expression was present in most samples of patients with MDS or AML but absent in those with secondary AML and CML. Thus, we have shown that BM-MNCs continuously produce MMP-9 and TIMP-1 and demonstrated that leukemic blast cells additionally secrete MMP-2 representing a potential marker for dissemination in myeloproliferative malignancies.  (+info)

Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. (5/479)

A novel type II integral membrane protein has been identified in the course of screening for genes overexpressed in a mouse model of chronic myelogenous leukemia blast crisis. This new protein, designated NKCL, consists of a 210-amino acid polypeptide with a short, NH2-terminal cytoplasmic tail of 17 amino acids preceding a transmembrane domain and a COOH-terminal extracellular region. The COOH-terminal 132 amino acids bear typical features of the C-type animal lectin carbohydrate-recognition domain. The Nkcl gene is unique in that it maps just proximal to the region of the genome that encodes group V members of the C-type animal lectin family near the natural killer gene complex on mouse chromosome 6, but its protein product also has features of several group II C-type animal lectins. Most notably, it has a complete Ca2+-binding site 2, which forms part of the sugar-binding site in other members of the family, and binds mannose in a Ca2+-dependent manner. Moreover, its expression is not restricted to natural killer cells, as reported for the majority of group V lectins. Nkcl is expressed in pluripotent myeloid precursors, precursor and mature macrophages, and neutrophils.  (+info)

Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia. (6/479)

Thirty-six adults with chronic myelogenous leukemia (CML) in second or greater chronic phase, accelerated phase, or blast crisis underwent marrow or blood stem cell transplantation from an HLA-matched sibling using high-dose thiotepa, busulfan and cyclophosphamide (TBC) as the preparative regimen. All evaluable patients engrafted and had complete donor chimerism. One patient failed to clear meningeal leukemia, and one patient had one of 30 metaphases positive for the Philadelphia chromosome at 2 months post transplant. The remainder of the patients studied had eradication of CML documented by cytogenetics and/or Southern blot for BCR gene rearrangement, and 13 of 15 patients studied became negative for the BCR gene rearrangement by polymerase chain reaction. Three-year relapse rate is 42% (95% CI, 19-64%). The relapse rate was significantly lower for patients transplanted without blast crisis (9% vs 100%, P < 0.001). Eight (22%, 95% CI, 10-39%) patients had severe or fatal veno-occlusive disease (VOD). Elevated liver enzymes within 1 month prior to transplantation and transplantation using marrow were significantly associated with the occurrence of VOD. Three-year survival is 28% (95% CI, 13-43%). Survival was significantly higher for patients transplanted without blast crisis (45% vs 0%, P = 0.01). TBC is an effective preparative regimen for CML in accelerated phase but not refractory blast crisis, and it should be used with caution in patients with prior hepatopathy who have an increased risk of severe VOD.  (+info)

Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. (7/479)

Gene targeting studies in mice have shown that the lack of Ikaros activity leads to T-cell hyperproliferation and T-cell neoplasia, establishing the Ikaros gene as a tumor suppressor gene in mice. This prompted us to investigate whether mutations in Ikaros play a role in human hematological malignancies. Reverse transcription-PCR was used to determine the relative expression levels of Ikaros isoforms in a panel of human leukemia/lymphoma cell lines and human bone marrow samples from patients with hematological malignancies. Among the cell lines examined, only BV-173, which was derived from a chronic myelogenous leukemia (CML) patient in lymphoid blast crisis, overexpressed the dominant-negative isoform, Ik-6. In 9 of 17 samples of patients in blast crisis of CML, Ikaros activity had been reduced either by drastically reducing mRNA expression (4 of 17) or by overexpressing the dominant-negative isoform Ik-6 (5 of 17). Significantly, expression of Ikaros isoforms seemed normal in chronic phase CML patients and patients with other hematological malignancies. In some cases, overexpression of the dominant-negative Ik-6 protein was confirmed by Western blot analysis, and Southern blot analysis indicated that decreases in Ikaros activity correlated with a mutation in the Ikaros locus. In summary, these findings suggest that a reduction of Ikaros activity may be an important step in the development of blast crisis in CML and provide further evidence that mutations that alter Ikaros expression may contribute to human hematological malignancies.  (+info)

Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance. (8/479)

Expression of the multidrug resistance (MDR) mechanisms P-glycoprotein (Pgp) and MDR-related protein (MRP) decrease cellular retention and consequently cytotoxicity of anthracyclines. MDR is expressed on normal human hematopoietic progenitors and leukemic blasts. Normal CD34(+) progenitors showed rhodamine efflux in 20% to 30% of the cells, which could be blocked by verapamil. These cells appeared noncycling, in contrast to the proliferating rhodamine bright (RhoB) cells. We postulated that MDR expression can be downregulated by proliferation induction. Triggering rhodamine dull (RhoD) CD34(+) cells to proliferate indeed resulted in a higher rhodamine retention and significantly decreased efflux modulation by verapamil (P =.04). Also in acute myeloid leukemia (AML), the proliferation rate (percentage S/G(2)+M and Iododeoxyuridine labelings index) was significantly less in the RhoD blasts (P +info)

This translocation is a remarkably specific marker for acute promyelocytic leukemia (ANLL-M3). This strong association is further exemplified by the fact that occasionally this translocation develops as a secondary aberration during CML blast transformation, with patients exhibiting disease characteristics indistinguishable from APL. Apart from these exceptional CML blast crisis patients, t(15;17) has not been detected in any malignancies other than ANLL-M3. t(15;17) APL patients usually exhibit disseminated intravascular coagulation (DIC) and hyper- or micro-granulated promyelocytes.. ...
A comparison was made between the agar and methylcellulose culture systems with respect to their ability to support the clonal growth of leukemic cells obtained from patients with acute myeloblastic leukemia, acute lymphoblastic leukemia, and chronic myelogenous leukemia in blastic crisis. The number of clusters and/or colonies formed and the morphology of the cells within them varied from patient to patient. Nevertheless, no significant difference between the two culture systems within given leukemic specimens was found. No significant differences were noted among three different conditioned media used as sources of colony-stimulating activity. Most of the cells within clusters and colonies were identified to be immature members of granulocyte-macrophage series or to be indistinguishable from the preculture leukemic blast cells by morphological and cell surface marker studies. Cells from myeloid crisis in chronic myelogenous leukemia grew well in the cultures, but cells from lymphoid crisis did ...
12 year old Fidan is suffering from Chronic Myeloid Leukemia since she is 5. As she never had access to any TKIs she started to get chemotherapy since she was diagnosed.. As if this was not enough, 2 years later her mother got another shocking news when she started feeling strange. This was a breast cancer. Instead of spending more time with her only child and worrying about her, she had to start caring about herself too, for both of them. There were two of them now against two cancers.. Mother and daughter are travelling to Iran very often for the chemotherapy procedures. Mother had her breast been amputated recently, and continues chemotherapy courses.. However, very unfortunately Fidans CML has recently progressed too far - to a Lymphoid Blast Crisis stage, and as the family doesnt have any opportunity and access to the Bone Marrow Transplant, she continues chemotherapy.. An interesting and a dreadful fact is - a mother and a daughter are both in remission almost at the same time, and then ...
Our observations suggest that the efficacy of a particular GPCR in inducing ATP release from nonexcitable cells will be limited by its capacity to coordinately couple to both PLC→Ca2+ mobilization and RhoGEF→Rho activation pathways. Although this will generally involve coupling to parallel Gq→ PLCβ→ and G12/13→ RhoGEF cascades, Gq has been implicated as an upstream inducer of Rho activation in some cell types, and G12/13 may regulate Ca2+ mobilization via Rho-dependent PLCε activation in other cellular contexts (30, 54, 55). Additionally, lymphoid blast crisis (lbc) Rho-GEF activity can augment Gq signaling via interactions independent of accumulated active RhoA (53). Thus cellular responses, such as ATP release, which require Gq→ PLC→ Ca2+ mobilization as necessary signals may be modulated by Rho signaling via multiple networks. Although PAR1 activation triggers markedly less inositol phosphate accumulation than M3R stimulation in 1321N1 astocytes, both receptors couple to PLC ...
At study entry, patients who were treated with: imatinib mesylate within the past 48 hours, interferon-alpha within the past 48 hours; homoharringtonine within the past 14 days; low-dose cytosine arabinoside within 7 days, moderate dose within 14 days, or high dose within 28 days; etoposide, anthracyclines, or mitoxantrone within 21 days; busulfan within the past six ...
This translocation is a remarkably specific marker for acute promyelocytic leukemia (ANLL-M3). This strong association is further exemplified by the fact that occasionally this translocation develops as a secondary aberration during CML blast transformation, with patients exhibiting disease characteristics indistinguishable from APL. Apart from these exceptional CML blast crisis patients, t(15;17) has not been detected in any malignancies other than ANLL-M3. t(15;17) APL patients usually exhibit disseminated intravascular coagulation (DIC) and hyper- or micro-granulated promyelocytes.. ...
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leukemia, The continuous cell line K-562 was established by Lozzio and Lozzio from the pleural effusion of a 53-year-old female with chronic myelogenous leukemia in terminal blast crises. - ...
This paper investigates a previously overlooked phenomenon in crisis response information systems; namely, inclusive crisis infrastructure. By expanding the well-acknowledged infrastructure concept with alternatives to understandthe nature and scope of inclusive crisis infrastructures, this paper contributes to closing the gap between theory and practice by raising some research questions critical to studying inclusive crisis infrastructures. The emerging literature on crisis response information systems suggests that external sourcing of information increasingly influences crisis response operations. To contribute to this discourse, the paper draws on Pipek and Wulfs (2009) definition of work infrastructures and Palen and Lius (2007) conceptualization of peer-to-peer communications to develop a better understanding of the crisis response arena as a whole. In doing so, this paper goes beyond the emphasis on event-based technologies that currently dominate the crisis response information ...
Cytogenetic and FISH analysis of bone marrow showed that most patients had a decrease in the fraction of BCR-ABL-or Philadelphia-positive cells, though typically marrow remained positive, often in a fairly high percentage of cells. Eventually some values fell within the normal range. "If we look with RT-PCR, which is more sensitive," Dr. Peterson says, "many were still positive for BCR-ABL." Patients who remained positive for BCR-ABL later progressed; some developed accelerated phase or blast crisis. "So we dont know that imatinib can cure CML," Dr. Peterson says. "That is our hope. And we see such good responses that we think survival will be lengthened. But we dont yet know that clearly." However, she adds, this study was done in pretreated patients. Similar studies in newly diagnosed patients ...
Effective responsiveness begins with training and practice before a crisis occurs. Firestorm clients are ready with well-rehearsed crisis communications plans, emergency protocols and clearly-defined processes to lead the organization forward.
We should also realize that crises are not an unusual visitation, but a normal part of life. Rather than ask, "Why did this happen to me?", we do better to simply accept that it has happened, that crises happen to everyone and just get on with learning to deal with it and move on. In any life, we can expect a smooth period where all goes well, followed by an unexpected crisis. You get over the crisis, and recover that smooth road… and then you get hit by another crisis. Sometimes, you get more than one at the same time.. Read More » ...
The crisis of 3 years in a child is a relatively short stage of life, which can be characterized by a duration of several months, and sometimes up to two years
Over borrowing by companies, states and households represents a global crisis in the making. The Institute of International Finance has just reported that…
In this installation I want to jump ahead in Greenhalghs paper to address her last cause of the EBM crisis: Poor fit for multimorbidity. Not to worry, I will come back in a future post to cover the remaining problems of EBM. I concur with Greenhalgh that individual studies have limited applicability by themselves in…
Greenhalgh and colleagues report that the second aspect of evidence based medicines crisis... is the sheer volume of evidence available. EBM is not the purveyor of what is studied and published. EBM is a set of skills to effectively locate, evaluate, and apply the best available evidence. For much of what we do there is…
A: Read our article HEALING CRISIS! Herbs dont cause any health problems. They help you to heal from them. You were experiencing healing crisis, which can be unpleasant; bu...
DORLHIAC-LLACER, P.E. et al. In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells. Braz J Med Biol Res [online]. 2001, vol.34, n.10, pp.1257-1263. ISSN 1414-431X. http://dx.doi.org/10.1590/S0100-879X2001001000004.. Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the complex using AML blast cells since RT-PCR analysis showed that AML cells express LDL receptor mRNA. The LDE:daunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (P,0.001; Student t-test). Moreover, this complex destroyed AML blast cells as efficiently as free daunorubicin. Thus, LDE might be a suitable carrier of chemotherapeutic agents targeting these ...
Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we r
Chronic Myelocytic Leukemia (CML) - Epidemiology Forecast to 2025 Size and Share Published in 2017-09-20 Available for US$ 2750 at Researchmoz.us
Learn more about Chronic Myelocytic Leukemia at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
There are several treatments used for blast phase chronic myelogenous leukemia. Learn about treatments that may be offered to treat blast phase CML.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
MicroRNA-mediated posttranscriptional regulation is an important epigenetic regulatory mechanism of gene expression, and its dysregulation is involved in the development and progression of a variety of malignancies, including chronic myeloid leukemia (CML). The BCR-ABL1 fusion gene is not only the initiating factor of CML, but it is also an important driving factor for blastic transformation. Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 tyrosine kinase activity, represented by imatinib, are currently the first-line treatment for CML. However, due to primary resistance or secondary resistance caused by mutations in the BCR-ABL1 kinase domain, TKIs cannot completely prevent the progression of CML; thus, the study of BCR-ABL1 gene expression regulation is of great significance. In this study, bioinformatics analysis and our results showed that miR-96 could directly bind to the 3UTR region of BCR-ABL1 to regulate fusion protein expression, thereby regulating its downstream signaling pathway ...
RNA binding proteins: pathways to blastic transformation. RNA binding proteins play an essential role in RNA metabolism because they regulate the mRNA fate from the active site of transcription to that of translation (17). In fact, nuclear RNA binding proteins, involved in the regulation of transcription, interact with the nascent pre-mRNA when genes are actively transcribed by RNA polymerase II. Following synthesis, other RNA binding proteins prepare the pre-mRNA for cytoplasmic export, which requires the activity of ribonucleoprotein capable of nucleocytoplasmic shuttling. In this initial journey, the mRNA becomes 5′-capped and polyadenylated and undergoes splicing. Once exported into the cytoplasm, the mature mRNA is transported to the translational machinery where, on association with ribosomes, it is decoded and used several times as a template for protein synthesis. During the entire process, the mRNA is not naked but different RNA binding proteins take turn and bind to regulatory ...
... is the type of cancer of the blood cells, deadly because it progresses more slowly than the acute forms of leukemia. A lot of white cells, known as granulocytes, are produced by the bone marrow, gradually crowding the bone marrow, and interfering with the normal production of blood cells. This is the forum for discussing anything related to this health condition
Chronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and oth
An established second-line drug for chronic myelogenous leukemia has high response rates when given to newly diagnosed patients as their first therapy for the disease, according to early results from...
The 3 phases of chronic myelogenous leukemia (CML), as defined by the World Health Organization (WHO),{ref1}{ref2} are listed below. Table. Phases of Chronic MyelogenousCML phase WHO defini... more
Keep up to date with the latest Chronic myelogenous leukemia (CML) information from Patient Power. Join our newsletter to be the first to find out whats new.
City of Hope researchers may have discovered a more effective treatment for patients with chronic myelogenous leukemia (CML) according to a study published in Nature Medicine.
Question - Menopausal due to chronic myelogenous leukemia. Diagnosed with fluid in cyst. Will it lead to cancer?. Ask a Doctor about when and why Ultra sound is advised, Ask an Oncologist
Established from the pleural effusion of a 32-year-old woman with Philadelphia chromosome-positive CML in blast crisis in 1981; described to contain the t(9;22) leading to BCR-ABL1 e13-a2 (b2-a2) fusion gene and a p53 ...
During the course of chronic myeloid leukemia (CML) progression to blast crisis (BC) is thought to be caused by genetic instability such as cytogenetic aberrations in addition to the translocation t(9;22)(q34;q11). We have shown previously that major route ACA indicate an unfavorable outcome (Fabarius et al., Blood 2011). We now investigate whether there is a correlation in time between...
The above dynamics work aggressively against traditional empirical management decision processes. Decisions must be made quickly with limited and often incorrect information.. A crisis is not business as usual. A crisis is business as unusual.. Crises have a short duration, but have consequences that can determine the viability of a business or organization for years to come. If you are explaining, you are losing.. Crises have impacts - for good and bad. Every crisis starts with a combination of opportunity and danger. Where the risk/crisis conundrum balances depends upon your initial critical decisions, your crisis communications, your monitoring of events, and your adjustments made to strategy and actions as events develop. Your companys reputation, brand, legacy, and profitability hang in the balance in a crisis. Crises are personal. Every crisis is a human crisis. It is your company. It is your people. It is your brand. It is your reputation. It is your career. Doing the wrong thing or ...
Crisis chat lines do exist for those dont feel comfortable talking to a crisis counselor by phone. Here are 3 crisis chat lines you can try.
Assign 9863 for CML in 2008. The 2010 diagnosis is the same histology. Per the Hematopoietic database, chronic and accelerated phase are alternate names. This is the same primary per Rule M2. Blast phase (crisis) is also an alternate name for CML, which makes the 2012 diagnosis the same primary per Rule M2. As you noted, not all histologies have transformations. If a transformation is not listed, rules M8-M13 do not apply. For these types of cases, use M15 and use the multiple primaries calculator. ...
Case Study 4 ± Crisis Blown Over Ques 1. Do you think that the Bangalore-based company had practiced participative management? Answer. During such a crisis
The euro zone sovereign debt crisis has eased in recent weeks, ECB Governing Council member Athanasios Orphanides said on Saturday, adding more needed to be done to convince markets the euro zone had an effective crisis handling mechanism in place.
The brutal stabbing of Pietermaritzburg businessman Ashraf Mohideen (57) at the behest of his son and the killers he hired, has thrown his family into crisis and caused his business to close down.
With the proportion of over 65s on the increase, Britain is facing its biggest ever crisis when it comes to care of the elderly. And without the money to resolve the issue, could technology be the sav...
CIOs continue to adapt to the new normal of the COVID-19 world, reworking previous plans and reprioritizing IT budgets. Here are five strategies CIOs should consider implementing to help their companies emerge stronger from the current crisis.
A large contributor to our crime crisis in the United States involves drug-related charges, which could be greatly alleviated through rehab programs.
Kimtex, Krizi Fırsata Çevirip İhracat Şampiyonu Oldu Kimtex Turns the Crisis into an Opportunity and Becomes the Export Winner Ar-Ge ye büyük önem veren Kimtex in kendine özel tasarımlar gerçekleştirdikleri
WASHINGTON (AP) - The standoff that partially shut down the U.S. government persisted with no sign of a breakthrough Tuesday, as the Democra…
A crisis from early-childhood-education to post-grad - 23 Jan, 2018 A crisis from early-childhood-education to post-grad Mark Wegierski If there is anything that left-liberals in Canada clearly and unequivocally understand ... ...
世界宣明會是一個基督教救援及發展機構,一直以兒童為中心,致力為貧困孩子、家庭及社區帶來轉機和希望。現時,宣明會的工作遍及全球近100個國家,援助不分宗教、種族和性別。
The graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation (alloSCT) is potent against chronic phase chronic myelogenous leukemia (CP-CML), but blast crisis CML (BC-CML) and acute myeloid leukemias (AML) are GVL resistant. To understand GVL resistance, we studied GVL against mouse models of CP-CML, BC-CML, and AML generated by the transduction of mouse BM with fusion cDNAs derived from human leukemias. Prior work has shown that CD4+ T cell-mediated GVL against CP-CML and BC-CML required intact leukemia MHCII; however, stem cells from both leukemias were MHCII negative. Here, we show that CP-CML, BC-CML, and AML stem cells upregulate MHCII in alloSCT recipients. Using gene-deficient leukemias, we determined that BC-CML and AML MHC upregulation required IFN-γ stimulation, whereas CP-CML MHC upregulation was independent of both the IFN-γ receptor (IFN-γR) and the IFN-γ/γ receptor IFNAR1. Importantly, IFN-γR-deficient BC-CML and AML were completely resistant ...
The graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation (alloSCT) is potent against chronic phase chronic myelogenous leukemia (CP-CML), but blast crisis CML (BC-CML) and acute myeloid leukemias (AML) are GVL resistant. To understand GVL resistance, we studied GVL against mouse models of CP-CML, BC-CML, and AML generated by the transduction of mouse BM with fusion cDNAs derived from human leukemias. Prior work has shown that CD4+ T cell-mediated GVL against CP-CML and BC-CML required intact leukemia MHCII; however, stem cells from both leukemias were MHCII negative. Here, we show that CP-CML, BC-CML, and AML stem cells upregulate MHCII in alloSCT recipients. Using gene-deficient leukemias, we determined that BC-CML and AML MHC upregulation required IFN-γ stimulation, whereas CP-CML MHC upregulation was independent of both the IFN-γ receptor (IFN-γR) and the IFN-γ/γ receptor IFNAR1. Importantly, IFN-γR-deficient BC-CML and AML were completely resistant ...
The graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation (alloSCT) is potent against chronic phase chronic myelogenous leukemia (CP-CML), but blast crisis CML (BC-CML) and acute myeloid leukemias (AML) are GVL resistant. To understand GVL resistance, we studied GVL against mouse models of CP-CML, BC-CML, and AML generated by the transduction of mouse BM with fusion cDNAs derived from human leukemias. Prior work has shown that CD4+ T cell-mediated GVL against CP-CML and BC-CML required intact leukemia MHCII; however, stem cells from both leukemias were MHCII negative. Here, we show that CP-CML, BC-CML, and AML stem cells upregulate MHCII in alloSCT recipients. Using gene-deficient leukemias, we determined that BC-CML and AML MHC upregulation required IFN-γ stimulation, whereas CP-CML MHC upregulation was independent of both the IFN-γ receptor (IFN-γR) and the IFN-γ/γ receptor IFNAR1. Importantly, IFN-γR-deficient BC-CML and AML were completely resistant ...
The graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation (alloSCT) is potent against chronic phase chronic myelogenous leukemia (CP-CML), but blast crisis CML (BC-CML) and acute myeloid leukemias (AML) are GVL resistant. To understand GVL resistance, we studied GVL against mouse models of CP-CML, BC-CML, and AML generated by the transduction of mouse BM with fusion cDNAs derived from human leukemias. Prior work has shown that CD4+ T cell-mediated GVL against CP-CML and BC-CML required intact leukemia MHCII; however, stem cells from both leukemias were MHCII negative. Here, we show that CP-CML, BC-CML, and AML stem cells upregulate MHCII in alloSCT recipients. Using gene-deficient leukemias, we determined that BC-CML and AML MHC upregulation required IFN-γ stimulation, whereas CP-CML MHC upregulation was independent of both the IFN-γ receptor (IFN-γR) and the IFN-γ/γ receptor IFNAR1. Importantly, IFN-γR-deficient BC-CML and AML were completely resistant ...
K-562 Cell Slide (Human (53yrs, Female) bone marrow, chronic myelogenous leukemia (CML)) (5 slides/pk) Slide for ICC HCLS-17004 K-562 Cell Slide (Human (53yrs, Female) bone marrow, chronic myelogenous leukemia (CML)) (5 slides/pk) Slide for ICC HCLS-17004
Chronic myeloid leukemia is the tumour that occurs in blood cells and bone marrow, which is the soft parts inside bones where blood cells are produced.
AMA : Kronik Miyeloid L semi (KML) klonal bir k k h cre hastal d r ve BCR-ABL f zyon geni ile ili kilidir. Hastal k tedavi edilmedi i zaman, kronik evreden h zlanm evreye ilerler ve sonunda akut l semi ile sonu lan r. L semik transformasyonda temel olarak gerekli olan ve klinik olarak ili kili onkoproteinlerin belirlenmesi spesifik anti-l semik ila lar i in yeni molek ler hedef olabilecekleri i in nemlidir. Bu al ma baz M s rl kronik evre KML hastalar nda HOXA9 gen sunum oran n belirlemede ve bunun BCR-ABL sunumu ile ili kisinin ve klinik neminin de erlendirilmesinde ba lang ad m d r ...
Chronic myelogenous leukemia (CML) is slow-progressing and associated with a specific genetic abnormality in the cell, called the Philadelphia chromosome.
Untreated chronic myeloid leukemia (CML) progresses from chronic phase to blastic crisis (BC). Increased genomic instability, deregulated proliferation, and loss of differentiation appear associated to BC, but the molecular alterations underlying the progression of CML are poorly characterized. MYC oncogene is frequently deregulated in human cancer, often associated with tumor progression. Genomic instability and induction of aberrant DNA replication are described as effects of MYC. In this report, we studied MYC activities in CML cell lines with conditional MYC expression with and without exposure to imatinib, the front-line drug in CML therapy. In cells with conditional MYC expression, MYC did not rescue the proliferation arrest mediated by imatinib but provoked aberrant DNA synthesis and accumulation of cells with 4C content. We studied MYC mRNA expression in 66 CML patients at different phases of the disease, and we found that MYC expression was higher in CML patients at diagnosis than ...
Chronic myelogenous leukemia (cml) | Chemotherapy and immunotherapy. Cancer: Treatment in Aachen, Germany ✈. Prices on BookingHealth.com - booking treatment online!
Blast cells from peripheral blood of 32 patients with acute leukemia were tested for their ability to react with a monoclonal antibody (D1.B6) specific for HLA-DR surface antigen. In order to evaluate the degree of leukemic cell differentiation a monoclonal antibody (R1.B19) specific for the granulocytopoietic lineage was also employed. The results demonstrated that a considerable proportion of blast cell populations expressed the HLA-DR antigen, while only a small fraction of cells expressed the myeloid antigen.
Learn about Chronic Myelogenous Leukemia symptoms and causes from experts at Boston Childrens, ranked best Childrens Hospital by US News.
Twenty four CML-patients, 22 (91.7%) with chronic phase and 2 (8.3%) under blast crisis, were studied. Thirteen (54.2%) were males, and 11 (45.8%) were females. The Sokal risk was low in 7 (29.2%), intermediate in 7 (29.2%), high in 6 (25%), and not evaluated in 4 (16.6%). Age, gender, phase of disease, TKI treatment and doses, molecular responses (at 6, 12, and 18 months) and haplotypes are listed in Table 1.. A total of seventeen different haplotypes were identified in CML-patients and controls. The frequency distribution indicates that 6 were only detected in CML-patients, 7 only in controls, and 4 in both groups. Heterozygous T-variant genotypes were observed in all 25 controls (100%), and in 18 CML-patients (75%). In this last group, 9 different T-variant haplotypes were identified as follows: full mutated-homozygote (TT-TT-TT) in 3 (12.5%), full mutated-heterozygous (CT-GT/A-CT) in 6 (25%), and other combinations of T-variants in 9 cases (37.5%). The remaining 6 (25%) CML-patients were ...
Pregnancy has been reported in patients with hematological malignancies, such as acute leukemia, Hodgkin and malignant lymphoma and chronic myelocytic leukemia. Only 12 cases of pregnancy occurring in patients with multiple myeloma (MM) have been rep
Downloadable ! Author(s): Graciela Laura Kaminsky. 1999 Abstract: The abruptness and virulence of the 1997 Asian crises have led many to claim that these crises are of a new breed and were thus unforecastable. This paper examines 102 financial crises in 20 countries and concludes that the Asian crises are not of a new variety. Overall, the 1997 Asian crises, as well as previous crises elsewhere, occur when economies are in distress, making the degree of fragility of the economy a useful indicator of future crises. Based on this idea, the paper proposes different composite leading indicators of crises, evaluated in terms of accuracy both in-sample and out-of-sample.
Generic Droxia is used for treating skin cancer, cancer of the ovary or chronic myelocytic leukemia that is recurrent, has spread or cannot be helped with surgery. It may also be used with radiation to control skin cancers of the head and neck.. Generic Droxia (Hydroxyurea 500 Mg) # Trackable Fast Delivery @ Online shop. Online shopping like never before! Get the latest trends ruling the charts in WorldWide. With the most greatest range of pharmacy!
This site is being served by a diagnosed CML patient. KMLTurkiye.com is serving the purpose to share the processes, treatment and side effects between diagnosed CML patients and their relatives. KMLTurkiye.com is not intended for medical advice in any way. Each treatment applied to CML patients are strictly personal and always should be advised to their own doctors by themselves. ...
Although it is widely believed that post-Mao China has fallen into a moral crisis, there are few scholarly analyses of its nature, causes, and consequences. Jiwei Cis Moral China in the Age of Reform-1 fills this gap by giving an unusually penetrating and insightful account of this crisis. There is much in Cis account that one can find thought-provoking and enlightening. Any good analysis of a crisis not only gives a good diagnosis but also sheds light on a possible solution. While the diagnosis of Chinas problem occupies a large part of the book, in a tentative yet careful manner Ci does suggest a way out. In my comment here, I focus on his suggestions as to how China can accomplish this.. For Ci, China has been plagued not just with one crisis but with a several. First is the crisis of justice and social order in the domain of the right-, manifested in the massive violations of basic ethical and legal norms in society. This has been caused by a number of interrelated crises in the domain of ...
study is to estimate the incidence of graft rejection and acute GVHD. A secondary objective will be to estimate the incidence of the ... One of the following high-risk malignancies: Chronic Myelogenous Leukemia: Chronic myelogenous leukemia in chronic phase, resistant .... Clinical Trial last updated 04/29/2016 - 10:52am.. ...
This essay investigates the role of literature and the links between literature, news-reporting, and history in the NAACP magazine The Crisis between 1910 and the early 1920s. We do not study literature per se and do not provide an analysis of the literary style, nor do we assess the literariness of the short stories and poems printed in the 1910s. Rather, we examine the place accorded literature in the Crisis and its role in relation to the rest of the magazine, from news commentary, political essays, and echoes of the African past, to illustrations and advertisements.
CrisisChat.org Retrieved February 29, 2012 What is Crisis Chat? Its a place to talk about problems and stress that may be difficult to talk about anywhere else… a place to find non-judgmental support and help through a difficult time. Crisis Chat is a place to find information on mental health problems and services. Its a confidential, secure, and anonymous way of reaching out for help when you dont know where else to turn. Who is it for? Crisis Chat is for anyone who is
We would like to develop software and documentation that will help people get from sequence to diagnosis. At the moment, we are focusing on identifying and classifying SNPs, but we will broaden this identification to other things like large deletions or insertions or repeats when we have more expertise. We are attempting to harness the power of other already existing tools, and we would also like to make this tool one that others can build upon. Specifically, our program will eventually be able to determine location based on BLAST, determine any SNPs based on NCBI SNP, and give a prognosis based on OMIM and online medical databases. ...
Neuchâtel crisis: Neuchâtel crisis, (1856-57), tense episode of Swiss history that had repercussions among the Great Powers of Europe. The Congress of Vienna (1814-15), in its general
For multinational companies operating in Russia and China, the key to success is finding ways to avoid PR crises, rather than managing them after they happen.
Thornton epub Theorizing, McColl BW, Greenhalgh A, Denes A, Allan SM, Rothwell NJ. epub Theorizing Crisis P is authoritative content. Stegner D, Haining EJ, Nieswandt B. Targeting epub Theorizing VI and the system Computational extent brain beating breeder.
Vanguardia y Humorismo Grafico En Crisis: La Guerra Civil Espanola (1936-1939) y La Revolucion Cubana (1959-1961) by Catala-Carrasco, Jorge L. available in Hardcover on Powells.com, also read sysnopsiEl libro analiza la relacion entre vanguardia y humorismo grafico en dos periodos historicos...
Dennis Carter 3781 Loving Acres Road Kansas City, MO 64110 (222)-995-2621 [email protected] Job Objective Searching for a Crisis Worker position in
Antibiotics are facing an existential crisis less than a century after their introduction. The bacteria-fighting drugs are becoming less effective as a result of their overuse in both humans and animals.
Heck, when he gets back from that ( he has to or is that where/how he meets reverse flash?) he might be broken from that experience and become something worse than Savitar ...
Michelle Janssen always struggled to relax, but when thoughts of catastrophe began popping into her head regularly, it exposed a much bigger problem.
HertsHelp is a free and confidential independent information and advice service providing a variety of support through a network of local organisations. Information includes advice about staying independent, help for carers or support in a crisis.
Hi this is going to be extremely long winded and for that I apologize, but I am a mother whose family is in real crisis right now. Please allow me to indulg...
An isochromosome of the long arm of chromosome 17, i(17q), is the most frequent genetic abnormality observed during the disease progression of Philadelphia chromosome-positive chronic myeloid leukemia (CML), and has been described as the sole anomaly in various other hematologic malignancies. The i(17q) hence plays a presumably important pathogenetic role both in leukemia development and progression. This notwithstanding, the molecular consequences of this abnormality have not been investigated in detail. We have analyzed 21 hematologic malignancies (8 CML in blast crisis, 8 myelodysplastic syndromes [MDS], 2 acute myeloid leukemias, 2 chronic lymphocytic leukemias, and 1 acute lymphoblastic leukemia) with i(17q) by fluorescence in situ hybridization (FISH). Using a yeast artificial chromosome (YAC) contig, derived from the short arm of chromosome 17, all cases were shown to have a breakpoint in 17p. In 12 cases, the breaks occurred within the Smith-Magenis Syndrome (SMS) common deletion region ...
RecName: Full=A-kinase anchor protein 13; Short=AKAP-13;AltName: Full=Protein kinase A-anchoring protein 13;AltName: Full=Breast cancer nuclear receptor-binding auxiliary protein;AltName: Full=Human thyroid-anchoring protein 31;AltName: Full=Guanine nucleotide exchange factor Lbc;AltName: Full=AKAP-Lbc;AltName: Full=P47;AltName: Full=Lymphoid blast crisis oncogene; Short=LBC oncogene;AltName: Full=Non-oncogenic Rho GTPase-specific GTP exchange ...
The cases, bibliography and associated comments included in this website and database have been provided by experts worldwide and reviewed by voluntary editorial working groups. The data and information is not guaranteed to be complete or to be fully up to date at any particular moment and it reflects the knowledge and views of the experts participating, not those of the World Health Organisation or the Italian National Transplant Centre.. ...
Chronic myelogenous leukemia (cml) | Chemotherapy and immunotherapy. Hematology: Treatment in Duesseldorf, Germany ✈. Prices on BookingHealth.com - booking treatment online!
Chemotherapy uses drugs to destroy cancer cells and is used to treat chronic myelogenous leukemia for different reasons. Learn about chemotherapy for CML.
Chronic Myelogenous Leukemia (CML) affects nearly 14,000 patients worldwide and is a disorder of the pluripotent hematopoietic stem cells with two distinct phas...
K562 cells were the first human immortalised myelogenous leukemia line to be established. K562 cells are of the erythroleukemia type, and the line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes and erythrocytes. In culture they exhibit much less clumping than many other suspension lines, presumably due to the downregulation of surface adhesion molecules by bcr:abl. However, another study suggests that bcr:abl over-expression may actually increase cell adherence to cell culture plastic. K562 cells can spontaneously develop characteristics similar to early-stage erythrocytes, granulocytes and monocytes and are easily killed by natural killer cells as they lack the MHC complex required to inhibit NK activity. They also lack any trace of Epstein-Barr virus and other herpesviruses. In addition to the ...
Specimen: Cerebrospinal Fluid (CSF). Container(s): CSF collection tubes. Preferred Vol: 10-20 mL; volume dependent on blast count Minimum Vol: dependent on blast count; consult lab. Note: Specimens for CSF Malignancy Workup must be coordinated with Pathologist/Cell Markers Laboratory prior to collection to ensure testing availability and adequate specimen collection.. For further information, contact Hematopathology (Cell Markers) at 206-987-2560 or Pathology 987-2103. Note: this test is for CSF workups only - for bone marrow, peripheral blood, or other body fluids, see separate listing(s). peripop ...
Brand Names Hydria®, Droxia (There may be other brand names for this medication) How is it Administered? Hydroxyurea is taken by mouth (as a capsule). What is it Used For? This drug is given to treat several kinds of cancer including melanoma, squamous cell carcinoma of head or neck, chronic myelocytic leukemia (CML), and recurrent, metastatic, or inoperable ovarian cancer. How Does it Work?
Product name: Droxia. Active ingredient: Hydroxyurea. Description: Generic Droxia is used for treating skin cancer, cancer of the ovary or chronic myelocytic leukemia that is recurrent, has spread or cannot be helped with surgery. It may also be used with radiation to control skin cancers of the head and neck.. Similar Titles: Hydrea. Manufacturer: Baramhaj Chemicals. Place an order: Click here. Payment method: Visa / MasterCard / Western Union. Delivery Time: 5-7 business days by Courier Service or 10-21 business days by Standard International Airmail. Loyalty Program: USPS - Fast Delivery Shipping 1-4 day USA Best quality drugs Fast Shipping USA Professional packaging 100% guarantee on delivery Best prices in the market Discounts for returning customers FDA approved productas 35000+ satisfied customers. ...
This trial investigated the long-term efficacy and tolerability of nilotinib in patients with resistant or intolerant chronic myeloid leukemia in blast crisis,
I continue to find reasons to be hopeful that one day, though probably not within my lifetime, medical researchers will overcome the challenges that thwart efforts to cure or at least contain most cancers, especially the more common ones. |p| My guarded optimism stems from the progress made in devising treatments for several less well-known malignancies. For many patients with cancers like chronic lymphoma, chronic myelocytic leukemia and now multiple myeloma, longevity lies in the ability of science to remain one step ahead of the malignancy by unraveling its genetic and molecular underpinnings and producing treatments tailored to counter them. |p|
Leukemias are malignancies of the blood and bone marrow and are classified as either acute or chronic malignancies of the myeloid--red blood cell, granulocyte, platelet lineage--or lymphoid--T or B lymphocyte. In this article we will focus on acute myeloblastic leukemias (AML) and recent advances in their classification and therapy.. In the United States, approximately 10,100 cases of AML are diagnosed each year and the yearly mortality rate from this disease is approximately 6,900 individuals. The incidence of AML is low in children (,1/100,000) and increases with age, such that by the time a person reaches the age of 80 the incidence is approximately 15/100,000 (Figure 1).1 Over 60% of patients are 55 years of age or older, making this a significant problem in the aging population.. ...
The next step in the logic of monetary interventionism is a currency crisis. The value of fiat currencies is ultimately supported by their governments and central banks. The balance sheets of central banks deteriorated considerably during the crisis and with them the banks capacity to defend the value of the currencies they issue. During the crisis, central banks accumulated bad assets: loans to zombie banks, overvalued asset-backed securities, bonds of troubled governments, etc.. In order to support the banking system during the crisis and to limit the number of bankruptcies, central banks had to keep interest rates at historically low levels. They thereby facilitated the accumulation of government debts. Consequently, the pressure on central banks to print the governments way out of their debt crisis is building up. Indeed, we have already seen quantitative easing I and quantitative easing II enacted by the Fed. The European Central Bank also started buying government bonds and accepting ...
ALL in a Days Work…. A Hematology Case Study about Leukemia by Sarah Wycoff. Questions to Consider:. How do you accurately determine a leukemic blast cell from a lymphocyte? What cytochemical stains can be used to diagnose Acute Lymphoblastic Leukemia?. Patient History. Slideshow 831065 by talasi
ALL in a Days Work…. A Hematology Case Study about Leukemia by Sarah Wycoff. Questions to Consider:. How do you accurately determine a leukemic blast cell from a lymphocyte? What cytochemical stains can be used to diagnose Acute Lymphoblastic Leukemia?. Patient History. Slideshow...
«Crisis» A crisis is any event that is, or is expected to lead to, an unstable and dangerous situation affecting an individual, group, community, or whole ...
Girl go to sleep. If my crazy ass cant decipher, then theres a problem? I liked JSP. Learned lots of lingo from him. Folks were going in on his fundme page...Mainly cuzz he always clowned folks with fundme pages, but that was just a part of his persona I guess. Id be lying if I said my mouth aint drop when I heard he was dead. My mind initially went to a few folks he helped to put on blast a few weeks back. Threats were being made back and forth...I was like ? But yeah, crazy mayne. Hopefully his fam can raise the money they seek. Were so quick to question...The others just crack open the pocket books. Murderers become millionaires...Man, they couldnt even get folks to donate to an elderly Black woman who couldnt afford her water bill...But why she dont, well I can barely afford, why come she aint...Much like Jarrett, were quick to hesitate when it comes to those fundmes. Rationalize it all you want, but...Obviously, many times, theyre needed...As Im guessing is the case with ...
Welcome to a family friendly blog that presents popular family issues and provides advice on family conflict. From dramas left behind by ancestors to generational curses, this family blog covers challenging issues. The more you know, the more empowered you will be when it comes to dealing with family problems, relationship challenges, and more! Solve family struggles and gain respect! Welcome to a site that puts family secrets on blast, so one can find spiritual healing!. ...
Welcome to a family friendly blog that presents popular family issues and provides advice on family conflict. From dramas left behind by ancestors to generational curses, this family blog covers challenging issues. The more you know, the more empowered you will be when it comes to dealing with family problems, relationship challenges, and more! Solve family struggles and gain respect! Welcome to a site that puts family secrets on blast, so one can find spiritual healing!. ...
Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get them in front of Issuus millions of monthly readers. Title: Coping with Crisis, issue 1, 2012, Author: Røde Kors, Name: Coping with Crisis, issue 1, 2012, Length: 24 pages, Page: 1, Published: 2012-05-09
"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC News. Retrieved 3 June 2013 ... "Terror attack: Blast on Tel Aviv bus; 28 hurt". Ynet News. 21 November 2012. Retrieved 27 January 2013.. ... "Deprived and Endangered: Humanitarian Crisis in the Gaza Strip". Human Rights Watch. Retrieved 3 September 2014.. ... Hamas's military wing claimed responsibility for the blast, stating that it was in response to the killing of the boy.[170] ...
For example, presence of a chloroma is sufficient to indicate chronic myelogenous leukemia has entered its 'blast crisis' phase ... An unusual variation of acute myelogenous leukemia associated with 8;21 chromosomal translocation and blast expression of the ...
"Blasts escalate Japan's nuclear crisis". World News Australia. 16 March 2011. Archived from the original on 7 April 2011. David ... While stepping-up monitoring of radiation levels on its own shores in face of the Fukushima nuclear power plant crisis, China, ... In response to the crisis, the Japanese government mobilized the Self-Defence Forces, while many countries sent search and ... The ministry excluded Fukushima from the results because of the ongoing nuclear crisis. The reconstruction of damaged areas in ...
"Blasts escalate Japan's nuclear crisis". World News Australia. March 16, 2011. Archived from the original on April 7, 2011. ... arsenic and other dangerous pollutants 2006 Côte d'Ivoire toxic waste dump Nigeria gully erosion crisis Sandoz chemical spill, ...
Their inactivation is related with progression into blast crisis. BCR/ABL pathway could also active PI64K/Akt/STAT5 pathway ... Some new translocate case of BAL has been reported, such as t(15,17) and t(12,13). For t(15;17), the blasts with morphology of ... BAL is hard to treat, usually the chemotherapy is chosen according to the morphology of the blast (ALL or AML). The stem cell ... BAL is difficult to treat, most patients receive treatment based on the morphology of blasts and get AML or ALL induction ...
"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. November 21, 2012. Retrieved November 21, 2012. "Hamas leader tells ... "Terror attack: Blast on Tel Aviv bus; 28 hurt". Ynet News. November 21, 2012. Retrieved November 21, 2012. "הפיצוץ בת"א: "חשבנו ...
Total incidents: 18 "Syria crisis: Latakia blast rocks Assad stronghold". BBC News. 2 September 2015. Retrieved 19 August 2017 ... "Blast kills at least 10 at mosque in Sanaa". The Washington Post. 25 September 2015. Archived from the original on 25 September ... "Four fatal blasts in Maiduguri". news24. 21 September 2015. Retrieved 19 August 2017. "Yemen suicide bombing in Sanaa mosque ' ... Ludovica Iaccino (3 September 2015). "Boko Haram in Cameroon: 10 dead and 100 injured in Kerawa twin blasts". International ...
Hiyama, Hiroshi (15 March 2011). "Blasts, new fire escalate Japan's nuclear crisis". Google News. AFP. Retrieved 26 March 2011 ... "Japan nuclear crisis: Meltdown at Fukushima Daiichi plant may now be inevitable". New York Daily News. 17 March 2011. Sanger, ... "TEPCO: Unit No.4 blast due to hydrogen from Unit No.3". NHK. 16 May 2011. Archived from the original on 15 May 2011. Retrieved ... "Crisis continues at crippled Japanese nuclear power plants". VOA. 16 March 2011. Retrieved 26 March 2011. JAIF (26 June 2012) ...
It is highly expressed in blast crisis transition of chronic myeloid leukemia. When overexpressed by transfection, NME3 ...
Director Dan Wyant resigns after task force blasts MDEQ over Flint water crisis The Flint Journal via MLive.com, December 29, ... The Flint water crisis and the role of both political parties in creating and sustaining the crisis is highlighted. ... Don't Drink the Water (2017) A Brad Leo Lyon documentary film about the water crisis in Flint, Michigan and other communities. ... Main article: Flint water crisis. In April 2014, Flint switched its water supply from Lake Huron (via Detroit) to the Flint ...
Christopher Zara (30 April 2016). "Vietnam Dead Fish Crisis: Critics Blast Formosa Plastics As Environmental Disaster ... The 2016 Vietnam marine life disaster was a water pollution crisis affecting Hà Tĩnh, Quảng Bình, Quảng Trị and Thừa Thiên-Huế ... Mai Ngoc Chau; Yu-Huay Sun (4 May 2016). "Fish Death Crisis Prompts Vietnam Waste Water Probe". Blooomberg. Retrieved 8 May ... "Vietnam Minister Apologizes For 'Confused' And 'Slow' Response to Fish Crisis". Radio Free Asia. 29 April 2016. Retrieved 8 May ...
Moreover, it inhibits DNA repair, causing genomic instability and potentially causing the feared blast crisis in CML. ... "blast crisis".[citation needed] In 2000 Dr. John Kuriyan determined the mechanism by which STI-571 inhibits the Abl kinase ...
Ukraine crisis: Blast injures Luhansk rebel leader Plotnitsky, BBC News (7 August 2016) "UNIAN News. Latest news of Ukraine and ... Multiple war wounds, the effects of blast injuries took their toll." The website stated that security minister Leonid Pasechnik ...
Syria portal University portal "Syria crisis: Dozens killed by Aleppo university blasts". BBC. Retrieved 15 January 2013. World ... The blasts reportedly struck an area between Aleppo University's halls of residence and the architecture faculty. The initial ...
... it is called blast crisis. List of hematologic conditions Blastic phase chronic myelogenous leukemia entry in the public domain ... of the cells in the blood or bone marrow are blast cells (immature blood cells). When tiredness, fever, and an enlarged spleen ...
... were derived from a 39-year-old man with chronic myeloid leukemia in blast crisis. The original cell line contained ...
"The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis ( ...
He was diagnosed with leukemia early in 2010 and had survived numerous blast crises by the end of 2014. He was often keen to ...
Silvester, Norman (13 May 2012). "Rangers in crisis: David Murray blasts SFA after they condemn sale of club to Craig Whyte". ... "Rangers in crisis: Ibrox club face being stripped of five league titles and a battle to avoid SPL expulsion". The Daily Record ... "Rangers in crisis: SPL to investigate alleged Employment Benefit Trust payments to players". The Telegraph. 2 August 2012. " ...
Blast crisis is the final phase in the evolution of CML, and behaves like an acute leukemia, with rapid progression and short ... Blast crisis is diagnosed if any of the following are present in a patient with CML: >20% myeloblasts or lymphoblasts in the ... The accelerated phase is significant because it signals that the disease is progressing and transformation to blast crisis is ... blood or bone marrow Large clusters of blasts in the bone marrow on biopsy Development of a chloroma (solid focus of leukemia ...
The blast killed at least three people and injured another 10, including a boy age 15 and a policeman. On 25 February the death ... 2006 Kharkiv supermarket bombings Volnovakha bus attack Donetsk bus shelling incident "BBC News - Ukraine crisis: Deadly bomb ... "Blast hits march in eastern Ukraine, killing two - World news". Mail. 22 February 2015. Retrieved 28 February 2015. "Kharkiv ... "Deadly bomb blast hits rally in Ukraine". Al Jazeera. 22 February 2015. Retrieved 28 February 2015. Chamonikolas, Krystof (23 ...
Director Dan Wyant resigns after task force blasts MDEQ over Flint water crisis, MLive (December 29, 2015). Emily Lawler, Flint ... A December 2015 report by the Flint Water Advisory Task Force found that "primary responsibility" for the Flint water crisis ... the Michigan DEQ was criticized for its role in the Flint water crisis; agency officials repeatedly dismissed citizens' ... Wyant resigns in Flint water crisis, Detroit Free Press (December 29, 2015). Locations, Michigan Department of Environmental ...
... in blast crisis, and newly diagnosed. Due in part to the development of imatinib and related drugs, the five year survival rate ...
9p copy neutral-LOH with homozygous JAK2 mutation was also linked to an inferior outcome in MPN-blast crisis in comparison with ... was significantly associated with prior exposure to hydroxyurea as well as a complex karyotype in samples with MPN-blast crisis ... Blast phase patients with loss of chromosomal material on 7q showed poor survival. Loss of 7q is known to be predictive for ... The number of genomic alterations was more than 2 to 3 times greater in the blast phase as in the chronic phase of the disease ...
A new cold-blast process was successfully introduced here and, despite some early crises, the works prospered. By the mid-1850s ...
Tilton returned to television in 1994 with a new show called Pastor Tilton, a show with an emphasis on "demon blasting" ... One plaintiff, Vivian Elliott, won $1.5 million in 1994 when it was discovered that a family crisis center for which she had ... quoted in Christianity In Crisis by Hank Hanegraaff, Harvest House Publishers, 1993, p. 347. ... quoted in Christianity in Crisis by Hank Hanegraaff, Harvest House Publishers, 1993, p. 348. ...
Molecular characteristics of chronic myelogenous leukemia in blast crisis.. Blick M, Romero P, Talpaz M, Kurzrock R, Shtalrid M ...
... *U.S. President Donald Trump "forcibly" renews demand ...
... for alleged lack of urgency in the consideration and resolution of crises in the judiciary. ... The crisis reached a head last week when President Muhammadu Buhari suspended the Chief Justice of Nigeria, Walter Onnoghen, ... Speaking on the ongoing crisis, the NADL condemned the investigation of both the suspended CJN and acting CJN by the NJC. ... NADL called on political power holders and interest groups to stop politicising the crisis. I said the "clash of power" is ...
Gene context of Blast Crisis. *Four of 13 BCR/ABL transgenic founders developed a chronic MPD, but only one progressed to blast ... Disease relevance of Blast Crisis. *Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic ... Furthermore, most of the blast cells from patients in CML blast crisis, which are usually resistant to IFN-alpha therapy, ... to detect blast cells in CML crisis and also has the capability to detect PCNA in other cells associated with blast crisis [7]. ...
Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis.. Uchida T1, Kitaura J1, ... We have previously shown that elevated expression of Hairy enhancer of split 1 (Hes1) contributes to blast crisis transition in ... Thus, we have established mouse models of FIP1L1-PDGFRA-positive leukemia in myeloid blast crisis, which will help elucidate ... marrow cells expressing both Hes1 and FIP1L1-PDGFRα developed acute leukemia characterized by an expansion of myeloid blasts ...
Top doctors, health critics blast Health Minister Eric Hoskins for stem cell transplant crisis. ... minister Eric Hoskins drew heat from fellow doctors and political peers on Wednesday over Ontarios stem cell transplant crisis ...
... "blast crisis." Blast crisis of CML is an ominous clinical event that can further be divided based on the site of origin: ... fewer patients are progressing to the accelerated phase and blast crisis. Once blast crisis in CML has been diagnosed, an ... Extramedullary blast crisis is extremely rare and is defined as the development of extramedullary blasts infiltration ... R. Hehlmann, "How I treat CML blast crisis," Blood, vol. 120, no. 4, pp. 737-747, 2012. View at Publisher · View at Google ...
Catholic League Blasted on Twitter for Dismissing Churchs Sexual Abuse Crisis as Total Myth. by Ken Meyer , Aug 17th, 2018, ... There is no on-going crisis-its a total myth. In fact, there is no institution, private or public, that has less of a problem ... who made the counterargument that the media was trying to sensationalize a false crisis based on an inconclusive report. Heres ...
38 patients had a myeloid blast crisis and 20 had ALL or a lymphoid blast crisis. Treatment was given orally at daily doses ... The BCR-ABL tyrosine kinase inhibitor STI571 is well tolerated and has substantial activity in the blast crises of CML and in ... Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute ... All but one patient with a lymphoid blast crisis or ALL has relapsed. The most frequent adverse effects were nausea, vomiting, ...
A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases.. ...
Blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph1-positive) acute lymphocytic ... FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute ... FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute ... FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute ...
... Member Center:*Create ... Arctic Blast leaves Red Cross in blood shortage crisis. time.prefixdate:before{content:Posted: ;}time.prefixdate:before{ ... Those cancellations have left the Red Cross in a blood shortage crisis. Area residents are encouraged to donate blood if ...
Blast phase of chronic myelogenous leukaemia (CML), which can be discovered incidentally on FBC or in assessment of patients ... Blast crisis refers to the transformation of chronic myelogenous leukaemia (CML) from the chronic or accelerated phase to blast ... Diagnosis of the blast phase of CML is based on percentage of blasts in peripheral smear or bone marrow. ... no remission achieved or recurrence of blast crisis after stem cell transplant. ...
Leukemic blasts will cause pseudohypoxemia on ABG (so-called leukocyte larceny) due to continued oxygen consumption in the ABG ... HU is a well-tolerated oral option for therapy that has demonstrated effectiveness in blast count reduction. This should be ... It is exceedingly effective in reducing the circulating blasts by removing circulating WBCs and reinfusing leukocyte-depleted ... It is exceedingly effective in reducing the circulating blasts by removing circulating WBCs and reinfusing leukocyte-depleted ...
Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three ... Blast Crisis*. Bone Marrow / pathology. Cell Lineage*. Humans. In Situ Hybridization, Fluorescence. Leukemia, B-Cell / ... Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid. ... Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three ...
Isolated Ocular Manifestation of Relapsed Chronic Myelogenous Leukemia Presenting as Myeloid Blast Crisis in a Patient on ... We describe a unique case of CML relapse with blast phase involving the eye. A 66-year-old man with a known diagnosis of CML on ... Blast phase in chronic myelogenous leukemia (CML) has rarely been reported to involve extramedullary sites like skin, lymph ... The blasts expressed CD34, aberrant TdT, and a myeloid phenotype (CD13, CD33, and CD117). Fluorescence in situ hybridization ( ...
... called blast crisis (BC), which involves aggressive proliferation of immature blast cells. The frequent appearances of ... Karyotype abnormalities and their clinical significance in blast crisis of chronic myeloid leukemia. J Mol Med 1997;75:836-838. ... To identify gene(s) whose alteration by retrovirus insertion contributes to blast crisis of CML, p210BCR/ABL transgenic mice ... Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia ...
Cells from chronic myelogenous leukemia donors expressed this dual reactivity only at the stage of blast crisis. This type of ... and chronic myelogenous leukemia patients in blast crisis (CML-BC). Earlier studies demonstrated that nonhuman primate antisera ... of Normal and Leukemia-associated Antigens of Acute Myelomonocytic Leukemia and Chronic Myelogenous Leukemia in Blast Crisis. T ... of Normal and Leukemia-associated Antigens of Acute Myelomonocytic Leukemia and Chronic Myelogenous Leukemia in Blast Crisis ...
... troops may be fueling the militarys suicide crisis, according to a letter co-signed by 53 congressional members who are ... Are brain injuries from IED blasts causing the military suicide crisis? By U.S. News ... "Evidence has suggested that blast injuries, including but not limited to those causing damage to vision or hearing, can have a ... Traumatic brain injuries sustained by more than 200,000 U.S. troops may be fueling the militarys suicide crisis, according to ...
phase, accelerated phase or in blast crisis patients previously enrolled to. CAMN107A2109 trial in Poland and continuing the ... Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Previously Enrolled to ENACT ( ... Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Previously Enrolled to ENACT ( ... in blast crisis, accelerated phase and ch ...
... ... Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate.}, ... the clinical and genetic response to imatinib mesylate treatment of an ETV6/ABL1-positive CML patient diagnosed in blast crisis ... the clinical and genetic response to imatinib mesylate treatment of an ETV6/ABL1-positive CML patient diagnosed in blast crisis ...
BCR-ABL1- and CBFB-MYH11-positive chronic myeloid leukemia presenting with primary blast crisis and marrow fibrosis. ... BCR-ABL1- and CBFB-MYH11-positive chronic myeloid leukemia presenting with primary blast crisis and marrow fibrosis ...
We report here a series of five patients seen at a single institution over a 10 year period who developed blast crisis as the ... The blast cells were myeloid in three cases and lymphoid in two. In one case the relapse may have occurred in cells of donor ... We report here a series of five patients seen at a single institution over a 10 year period who developed blast crisis as the ... Relapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia: a report of five ...
Democrats blast latest Trump crisis. But what will they do? High levels of cancer-causing chemical found in mint and menthol e- ...
Treatment for Blast Crisis Phase Treatment at a specialized center with doctors who have expertise in treating CML patients is ... The first test determines whether the blast phase involves myeloid or lymphoid blast cells. This test is needed because the ... recommended for patients in the blast phase of the disease. Two important tests are needed before starting treatment for blast ... type of blast cells is a factor in the treatment decision. The second test, a BCR-ABL gene mutation analysis, checks for ...
  • 1. Imatinib - resistant or - intolerant Philadelphia chromosome-positive CML in chronic phase, accelerated phase or in blast crisis patients previously enrolled to CAMN107A2109 trial in Poland and continuing the treatment with nilotinib at the time of enrollment for this trial. (knowcancer.com)
  • The drug is approved in multiple contexts of Philadelphia chromosome-positive CML, including after stem cell transplant, in blast crisis, and newly diagnosed. (wikipedia.org)
  • When tiredness, fever, and an enlarged spleen occur during the blastic phase, it is called blast crisis. (wikipedia.org)
  • ISLAMABAD (Reuters) -- A bomb blast has killed around 40 worshippers attending Friday prayers at a mosque in a remote area of northwest Pakistan, a senior official told Reuters. (rferl.org)
  • Are brain injuries from IED blasts causing the military suicide crisis? (nbcnews.com)
  • Traumatic brain injuries sustained by more than 200,000 U.S. troops may be fueling the military's suicide crisis, according to a letter co-signed by 53 congressional members who are seeking additional data to investigate the new theory. (nbcnews.com)
  • At least three veterans groups, including the Blinded Veterans Association, are backing the congressional push to - as the letter to DOD and VA states - "get a better understanding of the connection between blast injuries and suicide. (nbcnews.com)
  • Health minister Eric Hoskins drew heat from fellow doctors and political peers on Wednesday over Ontario's stem cell transplant crisis, which has seen under-funded hospital programs rationing life-saving treatment as patients are dying on unacceptably long wait lists. (thestar.com)
  • On 8 May 2014, a bomb blast leveled the Carlton Citadel Hotel in Aleppo, Syria, killing 14-50. (wikipedia.org)
  • NICOSIA, Cyprus (AP) -- Cyprus may presell the country's offshore natural gas reserves to raise cash quickly and pull it out of its deep financial crisis, the country's finance minister said Thursday. (yahoo.com)
  • Both situations would likely have led to a significant international financial crisis. (wikipedia.org)
  • On 4 December 2008, The Australian newspaper reported that Bidgood made a speech in parliament declaring that the Global financial crisis of 2008 was an act of God, linking it to the end of the world: "I believe there is God's justice in action in what is going on here. (wikipedia.org)
  • After the 1997 Asian financial crisis, Phase 2 never began. (wikipedia.org)
  • It said the council should have acted earlier and decisively at its Tuesday meeting to avert a constitutional crisis. (allafrica.com)
  • With an increasing number of political casualties, it became a protracted political event, referred to by some as a constitutional crisis. (wikipedia.org)
  • At least 40 others were wounded in the blasts, which went off as worshippers were attending Friday prayers in the town of Khanaquin. (rferl.org)
  • Blast phase of chronic myelogenous leukaemia (CML), which can be discovered incidentally on FBC or in assessment of patients with symptoms and signs such as fever, fatigue, weight loss, anaemia, thrombocytopenia, or splenomegaly. (bmj.com)