An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
BENZOIC ACID amides.
Brief therapeutic approach which is ameliorative rather than curative of acute psychiatric emergencies. Used in contexts such as emergency rooms of psychiatric or general hospitals, or in the home or place of crisis occurrence, this treatment approach focuses on interpersonal and intrapsychic factors and environmental modification. (APA Thesaurus of Psychological Index Terms, 7th ed)
Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)
The phase of chronic myeloid leukemia following the chronic phase (LEUKEMIA, MYELOID, CHRONIC-PHASE), where there are increased systemic symptoms, worsening cytopenias, and refractory LEUKOCYTOSIS.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
The short, acrocentric human chromosomes, called group G in the human chromosome classification. This group consists of chromosome pairs 21 and 22 and the Y chromosome.
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
The parent cells that give rise to both cells of the GRANULOCYTE lineage and cells of the monocyte/macrophage lineage.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
A dangerous life-threatening hypermetabolic condition characterized by high FEVER and dysfunction of the cardiovascular, the nervous, and the gastrointestinal systems.
An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Mapping of the KARYOTYPE of a cell.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
A specific pair of GROUP C CHROMSOMES of the human chromosome classification.
Disease having a short and relatively severe course.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Significant decline in economic activity spread across the economy, lasting more than a few months, normally visible in real gross domestic product, real income, employment, industrial production, and wholesale-retail sales. (National Bureau of Economic Research, Inc, www.nber.org/cycles.html, accessed 4/23/2009)
Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
Progenitor cells from which all blood cells derive.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
RNA present in neoplastic tissue.
A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthophosphate. EC 3.1.3.-.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.
Catalyze the hydrolysis of nucleosides with the elimination of ammonia.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
DNA present in neoplastic tissue.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Agents that inhibit PROTEIN KINASES.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The return of a sign, symptom, or disease after a remission.
Books designed to give factual information or instructions.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Toward a leukemia treatment strategy based on the probability of stem cell death: an essay in honor of Dr. Emil J Freireich. (1/479)

Dr. Emil J Freireich is a pioneer in the rational treatment of cancer in general and leukemia in particular. This essay in his honor suggests that the cell kill concept of chemotherapy of acute myeloblastic leukemia be extended to include two additional ideas. The first concept is that leukemic blasts, like normal hemopoietic cells, are organized in hierarchies, headed by stem cells. In both normal and leukemic hemopoiesis, killing stem cells will destroy the system; furthermore, both normal and leukemic cells respond to regulators. It follows that acute myelogenous leukemia should be considered as a dependent neoplasm. The second concept is that cell/drug interaction should be considered as two phases. The first, or proximal phase, consists of the events that lead up to injury; the second, or distal phase, comprises the responses of the cell that contribute to either progression to apoptosis or recovery. Distal responses are described briefly. Regulated drug sensitivity is presented as an example of how distal responses might be used to improve treatment.  (+info)

Prognostic significance of bone marrow biopsy in essential thrombocythemia. (2/479)

BACKGROUND AND OBJECTIVE: The diagnostic and prognostic value of bone marrow biopsy (BMB) has been widely investigated in patients with chronic myeloproliferative disorders (CMPD). The present study is based on a review of the results of routine BMBs taken from 93 essential thrombocythemia (ET) patients at the time of diagnosis. DESIGN AND METHODS: The common BMB histologic parameters and clinico-hematologic variables were considered for diagnostic and prognostic purposes. Clinico-pathologic correlations were looked for univariately. Moreover, the diagnostic significance of the histologic findings was tested by means of cluster analysis. Overall survival and event-free survival were considered as prognostic endpoints. RESULTS: There were no correlations between the clinic and pathologic findings, and none of the histologic and clinical parameters was predictive of survival or the occurrence of major clinical events. Cluster analysis of the BMB findings revealed two distinct morphologic patterns: one was clearly myeloproliferative; the other had somewhat dysplastic features. The event-free and overall survival rates in the latter group were significantly worse (p = 0.0377 and p = 0.0162 respectively), with major ischemic events accounting for most of the difference in event-free survival. INTERPRETATION AND CONCLUSIONS: These results have no clearcut counterpart in the literature, but we feel that dysplastic BMB findings could be included in the definition of ET prognostic scores in order to allow therapeutic strategies to be adapted to the level of risk.  (+info)

Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. (3/479)

Studies in cell lines have indicated that expression of the BCL-2 family of proteins is an important determinant of chemotherapy-induced apoptosis; however, the level of expression of these proteins in childhood acute lymphoblastic leukemia (ALL) has not been extensively reported. Using quantitative Western blotting we have determined the level of expression of BCL-2, BAX, MCL-1, and BCL-X in lymphoblasts from 47 children with ALL (33 at presentation only, 4 at relapse only, and 10 at both presentation and on relapse). Results were determined as a ratio to actin as an internal control. BCL-2, BAX, and MCL-1 were detected in all samples. BCL-XL was only detected in 6 cases (4 at presentation and 2 at relapse) and BCL-XS in none. No correlation was found between expression and white blood cell count, age at diagnosis, gender, or blast karyotype. BCL-2 levels and the BCL/BAX and MCL-1/BAX ratios were found to be significantly higher in B-lineage as compared with T-lineage disease (P <.003,.02, and.02, respectively). No consistent pattern of change in expression was noted in the 10 cases studied at both presentation and relapse. Kaplan-Meier analysis showed a significant correlation between high BAX expression and an increased probability of relapse (P <.05 by the log rank test), suggesting that chemosensitivity in leukemic blasts may be regulated by factors that override the BCL-2 pathway.  (+info)

Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. (4/479)

The two matrix metalloproteinases (MMPs) Mr 72,000 type IV collagenase (MMP-2, gelatinase A) and Mr 92,000 type IV collagenase (MMP-9, gelatinase B) play key roles in tissue remodeling and tumor invasion by digestion of extracellular matrix barriers. We have investigated the production of these two enzymes as well as the membrane-type MMP (MT1-MMP) and the tissue inhibitors of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 in the bone marrow mononuclear cells (BM-MNCs) of patients with acute myeloid leukemia (AML; n = 24), chronic myeloid leukemia (CML; n = 17), myelodysplastic syndromes (MDS; n = 8), and healthy donors (n = 5). Zymographic analysis of BM-MNC-conditioned medium showed that a Mr 92,000 gelatinolytic activity, identified as MMP-9 by Western blotting, was constitutively released from cells of all patients and healthy individuals examined in this study. In contrast, MMP-2 secretion was found to be absent in all samples from healthy donors but present in 8 of 11 (73%) of the samples from patients with primary AML, 7 of 8 (88%) with secondary AML, and only 1 of 5 (20%) cases with AML in remission, indicating MMP-2 to be produced by the leukemic blasts. MMP-2 release was not detected in CML cell-conditioned medium with the exception of two cases, both patients either being in or preceding blast crisis. In MDS, MMP-2 was found in three of eight (38%) of the patients, two of them undergoing progression of disease within 12 months. Quantitative Northern blot analysis in freshly isolated BM-MNCs showed a relatively low constitutive expression of TIMP-1 in all samples, whereas MMP-9 gene transcription was higher in healthy donors and CML samples, than in AML and MDS. Reverse transcriptase-PCR analysis revealed the presence of TIMP-2 mRNA in the majority of MMP-2-releasing BM-MNCs. MT1-MMP expression was present in most samples of patients with MDS or AML but absent in those with secondary AML and CML. Thus, we have shown that BM-MNCs continuously produce MMP-9 and TIMP-1 and demonstrated that leukemic blast cells additionally secrete MMP-2 representing a potential marker for dissemination in myeloproliferative malignancies.  (+info)

Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. (5/479)

A novel type II integral membrane protein has been identified in the course of screening for genes overexpressed in a mouse model of chronic myelogenous leukemia blast crisis. This new protein, designated NKCL, consists of a 210-amino acid polypeptide with a short, NH2-terminal cytoplasmic tail of 17 amino acids preceding a transmembrane domain and a COOH-terminal extracellular region. The COOH-terminal 132 amino acids bear typical features of the C-type animal lectin carbohydrate-recognition domain. The Nkcl gene is unique in that it maps just proximal to the region of the genome that encodes group V members of the C-type animal lectin family near the natural killer gene complex on mouse chromosome 6, but its protein product also has features of several group II C-type animal lectins. Most notably, it has a complete Ca2+-binding site 2, which forms part of the sugar-binding site in other members of the family, and binds mannose in a Ca2+-dependent manner. Moreover, its expression is not restricted to natural killer cells, as reported for the majority of group V lectins. Nkcl is expressed in pluripotent myeloid precursors, precursor and mature macrophages, and neutrophils.  (+info)

Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia. (6/479)

Thirty-six adults with chronic myelogenous leukemia (CML) in second or greater chronic phase, accelerated phase, or blast crisis underwent marrow or blood stem cell transplantation from an HLA-matched sibling using high-dose thiotepa, busulfan and cyclophosphamide (TBC) as the preparative regimen. All evaluable patients engrafted and had complete donor chimerism. One patient failed to clear meningeal leukemia, and one patient had one of 30 metaphases positive for the Philadelphia chromosome at 2 months post transplant. The remainder of the patients studied had eradication of CML documented by cytogenetics and/or Southern blot for BCR gene rearrangement, and 13 of 15 patients studied became negative for the BCR gene rearrangement by polymerase chain reaction. Three-year relapse rate is 42% (95% CI, 19-64%). The relapse rate was significantly lower for patients transplanted without blast crisis (9% vs 100%, P < 0.001). Eight (22%, 95% CI, 10-39%) patients had severe or fatal veno-occlusive disease (VOD). Elevated liver enzymes within 1 month prior to transplantation and transplantation using marrow were significantly associated with the occurrence of VOD. Three-year survival is 28% (95% CI, 13-43%). Survival was significantly higher for patients transplanted without blast crisis (45% vs 0%, P = 0.01). TBC is an effective preparative regimen for CML in accelerated phase but not refractory blast crisis, and it should be used with caution in patients with prior hepatopathy who have an increased risk of severe VOD.  (+info)

Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. (7/479)

Gene targeting studies in mice have shown that the lack of Ikaros activity leads to T-cell hyperproliferation and T-cell neoplasia, establishing the Ikaros gene as a tumor suppressor gene in mice. This prompted us to investigate whether mutations in Ikaros play a role in human hematological malignancies. Reverse transcription-PCR was used to determine the relative expression levels of Ikaros isoforms in a panel of human leukemia/lymphoma cell lines and human bone marrow samples from patients with hematological malignancies. Among the cell lines examined, only BV-173, which was derived from a chronic myelogenous leukemia (CML) patient in lymphoid blast crisis, overexpressed the dominant-negative isoform, Ik-6. In 9 of 17 samples of patients in blast crisis of CML, Ikaros activity had been reduced either by drastically reducing mRNA expression (4 of 17) or by overexpressing the dominant-negative isoform Ik-6 (5 of 17). Significantly, expression of Ikaros isoforms seemed normal in chronic phase CML patients and patients with other hematological malignancies. In some cases, overexpression of the dominant-negative Ik-6 protein was confirmed by Western blot analysis, and Southern blot analysis indicated that decreases in Ikaros activity correlated with a mutation in the Ikaros locus. In summary, these findings suggest that a reduction of Ikaros activity may be an important step in the development of blast crisis in CML and provide further evidence that mutations that alter Ikaros expression may contribute to human hematological malignancies.  (+info)

Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance. (8/479)

Expression of the multidrug resistance (MDR) mechanisms P-glycoprotein (Pgp) and MDR-related protein (MRP) decrease cellular retention and consequently cytotoxicity of anthracyclines. MDR is expressed on normal human hematopoietic progenitors and leukemic blasts. Normal CD34(+) progenitors showed rhodamine efflux in 20% to 30% of the cells, which could be blocked by verapamil. These cells appeared noncycling, in contrast to the proliferating rhodamine bright (RhoB) cells. We postulated that MDR expression can be downregulated by proliferation induction. Triggering rhodamine dull (RhoD) CD34(+) cells to proliferate indeed resulted in a higher rhodamine retention and significantly decreased efflux modulation by verapamil (P =.04). Also in acute myeloid leukemia (AML), the proliferation rate (percentage S/G(2)+M and Iododeoxyuridine labelings index) was significantly less in the RhoD blasts (P +info)

TY - JOUR. T1 - Immunophenotypic and genotypic characteristics of chronic myelogenous leukemia in blast crisis. AU - Yen, C. C.. AU - Liu, J. H.. AU - Wang, W. S.. AU - Fan, F. S.. AU - Chiou, T. J.. AU - Tai, C. J.. AU - Yang, M. H.. AU - Chao, T. C.. AU - Hsiao, L. T.. AU - Chen, P. M.. PY - 2000. Y1 - 2000. N2 - Background. Chronic myelogenous leukemia (CML) may transform into blast crisis (BC) if not properly treated. Among patients with transformation, 20% to 30% will develop BC with lymphoid-associated antigens (Ly-BC), and the remaining cases with myeloid-associated antigens (My-BC) or with both (Mix-BC). In this study, we investigated the lineage of blast cells in CML-BC using immunophenotypic and genetic analyses and analyzed the prognostic significance of genotypic change in CML-BC. Methods. Twenty-one patients with CML-BC diagnosed at the Taipei Veterans General Hospital from 1982 to 1992 were included. Immunophenotyping was done by using the avidin-biotin immunoperoxidase technique. ...
This translocation is a remarkably specific marker for acute promyelocytic leukemia (ANLL-M3). This strong association is further exemplified by the fact that occasionally this translocation develops as a secondary aberration during CML blast transformation, with patients exhibiting disease characteristics indistinguishable from APL. Apart from these exceptional CML blast crisis patients, t(15;17) has not been detected in any malignancies other than ANLL-M3. t(15;17) APL patients usually exhibit disseminated intravascular coagulation (DIC) and hyper- or micro-granulated promyelocytes.. ...
A comparison was made between the agar and methylcellulose culture systems with respect to their ability to support the clonal growth of leukemic cells obtained from patients with acute myeloblastic leukemia, acute lymphoblastic leukemia, and chronic myelogenous leukemia in blastic crisis. The number of clusters and/or colonies formed and the morphology of the cells within them varied from patient to patient. Nevertheless, no significant difference between the two culture systems within given leukemic specimens was found. No significant differences were noted among three different conditioned media used as sources of colony-stimulating activity. Most of the cells within clusters and colonies were identified to be immature members of granulocyte-macrophage series or to be indistinguishable from the preculture leukemic blast cells by morphological and cell surface marker studies. Cells from myeloid crisis in chronic myelogenous leukemia grew well in the cultures, but cells from lymphoid crisis did ...
12 year old Fidan is suffering from Chronic Myeloid Leukemia since she is 5. As she never had access to any TKIs she started to get chemotherapy since she was diagnosed.. As if this was not enough, 2 years later her mother got another shocking news when she started feeling strange. This was a breast cancer. Instead of spending more time with her only child and worrying about her, she had to start caring about herself too, for both of them. There were two of them now against two cancers.. Mother and daughter are travelling to Iran very often for the chemotherapy procedures. Mother had her breast been amputated recently, and continues chemotherapy courses.. However, very unfortunately Fidans CML has recently progressed too far - to a Lymphoid Blast Crisis stage, and as the family doesnt have any opportunity and access to the Bone Marrow Transplant, she continues chemotherapy.. An interesting and a dreadful fact is - a mother and a daughter are both in remission almost at the same time, and then ...
Our observations suggest that the efficacy of a particular GPCR in inducing ATP release from nonexcitable cells will be limited by its capacity to coordinately couple to both PLC→Ca2+ mobilization and RhoGEF→Rho activation pathways. Although this will generally involve coupling to parallel Gq→ PLCβ→ and G12/13→ RhoGEF cascades, Gq has been implicated as an upstream inducer of Rho activation in some cell types, and G12/13 may regulate Ca2+ mobilization via Rho-dependent PLCε activation in other cellular contexts (30, 54, 55). Additionally, lymphoid blast crisis (lbc) Rho-GEF activity can augment Gq signaling via interactions independent of accumulated active RhoA (53). Thus cellular responses, such as ATP release, which require Gq→ PLC→ Ca2+ mobilization as necessary signals may be modulated by Rho signaling via multiple networks. Although PAR1 activation triggers markedly less inositol phosphate accumulation than M3R stimulation in 1321N1 astocytes, both receptors couple to PLC ...
At study entry, patients who were treated with: imatinib mesylate within the past 48 hours, interferon-alpha within the past 48 hours; homoharringtonine within the past 14 days; low-dose cytosine arabinoside within 7 days, moderate dose within 14 days, or high dose within 28 days; etoposide, anthracyclines, or mitoxantrone within 21 days; busulfan within the past six ...
This translocation is a remarkably specific marker for acute promyelocytic leukemia (ANLL-M3). This strong association is further exemplified by the fact that occasionally this translocation develops as a secondary aberration during CML blast transformation, with patients exhibiting disease characteristics indistinguishable from APL. Apart from these exceptional CML blast crisis patients, t(15;17) has not been detected in any malignancies other than ANLL-M3. t(15;17) APL patients usually exhibit disseminated intravascular coagulation (DIC) and hyper- or micro-granulated promyelocytes.. ...
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leukemia, The continuous cell line K-562 was established by Lozzio and Lozzio from the pleural effusion of a 53-year-old female with chronic myelogenous leukemia in terminal blast crises. - ...
This paper investigates a previously overlooked phenomenon in crisis response information systems; namely, inclusive crisis infrastructure. By expanding the well-acknowledged infrastructure concept with alternatives to understandthe nature and scope of inclusive crisis infrastructures, this paper contributes to closing the gap between theory and practice by raising some research questions critical to studying inclusive crisis infrastructures. The emerging literature on crisis response information systems suggests that external sourcing of information increasingly influences crisis response operations. To contribute to this discourse, the paper draws on Pipek and Wulfs (2009) definition of work infrastructures and Palen and Lius (2007) conceptualization of peer-to-peer communications to develop a better understanding of the crisis response arena as a whole. In doing so, this paper goes beyond the emphasis on event-based technologies that currently dominate the crisis response information ...
Cytogenetic and FISH analysis of bone marrow showed that most patients had a decrease in the fraction of BCR-ABL-or Philadelphia-positive cells, though typically marrow remained positive, often in a fairly high percentage of cells. Eventually some values fell within the normal range. If we look with RT-PCR, which is more sensitive, Dr. Peterson says, many were still positive for BCR-ABL. Patients who remained positive for BCR-ABL later progressed; some developed accelerated phase or blast crisis. So we dont know that imatinib can cure CML, Dr. Peterson says. That is our hope. And we see such good responses that we think survival will be lengthened. But we dont yet know that clearly. However, she adds, this study was done in pretreated patients. Similar studies in newly diagnosed patients ...
Effective responsiveness begins with training and practice before a crisis occurs. Firestorm clients are ready with well-rehearsed crisis communications plans, emergency protocols and clearly-defined processes to lead the organization forward.
We should also realize that crises are not an unusual visitation, but a normal part of life. Rather than ask, Why did this happen to me?, we do better to simply accept that it has happened, that crises happen to everyone and just get on with learning to deal with it and move on. In any life, we can expect a smooth period where all goes well, followed by an unexpected crisis. You get over the crisis, and recover that smooth road… and then you get hit by another crisis. Sometimes, you get more than one at the same time.. Read More » ...
The crisis of 3 years in a child is a relatively short stage of life, which can be characterized by a duration of several months, and sometimes up to two years
Over borrowing by companies, states and households represents a global crisis in the making. The Institute of International Finance has just reported that…
In this installation I want to jump ahead in Greenhalghs paper to address her last cause of the EBM crisis: Poor fit for multimorbidity. Not to worry, I will come back in a future post to cover the remaining problems of EBM. I concur with Greenhalgh that individual studies have limited applicability by themselves in…
Greenhalgh and colleagues report that the second aspect of evidence based medicines crisis... is the sheer volume of evidence available. EBM is not the purveyor of what is studied and published. EBM is a set of skills to effectively locate, evaluate, and apply the best available evidence. For much of what we do there is…
A: Read our article HEALING CRISIS! Herbs dont cause any health problems. They help you to heal from them. You were experiencing healing crisis, which can be unpleasant; bu...
Ok so many states have done random covid testing and the results show that large portions of the population (up to 60x official numbers) already had the virus …
JA Denburg, WE Wilson, J Bienenstock; Basophil production in myeloproliferative disorders: increases during acute blastic transformation of chronic myeloid leuk
DORLHIAC-LLACER, P.E. et al. In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells. Braz J Med Biol Res [online]. 2001, vol.34, n.10, pp.1257-1263. ISSN 1414-431X. http://dx.doi.org/10.1590/S0100-879X2001001000004.. Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the complex using AML blast cells since RT-PCR analysis showed that AML cells express LDL receptor mRNA. The LDE:daunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (P,0.001; Student t-test). Moreover, this complex destroyed AML blast cells as efficiently as free daunorubicin. Thus, LDE might be a suitable carrier of chemotherapeutic agents targeting these ...
Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we r
Chronic Myelocytic Leukemia (CML) - Epidemiology Forecast to 2025 Size and Share Published in 2017-09-20 Available for US$ 2750 at Researchmoz.us
Learn more about Chronic Myelocytic Leukemia at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
There are several treatments used for blast phase chronic myelogenous leukemia. Learn about treatments that may be offered to treat blast phase CML.
Chronic myelogenous leukemia treatments include tyrosine kinase inhibitors, high-dose therapy with allogeneic transplantation, and other medications. Get detailed information about chronic myelogenous leukemia (CML) treatment options in this summary for clinicians.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
MicroRNA-mediated posttranscriptional regulation is an important epigenetic regulatory mechanism of gene expression, and its dysregulation is involved in the development and progression of a variety of malignancies, including chronic myeloid leukemia (CML). The BCR-ABL1 fusion gene is not only the initiating factor of CML, but it is also an important driving factor for blastic transformation. Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 tyrosine kinase activity, represented by imatinib, are currently the first-line treatment for CML. However, due to primary resistance or secondary resistance caused by mutations in the BCR-ABL1 kinase domain, TKIs cannot completely prevent the progression of CML; thus, the study of BCR-ABL1 gene expression regulation is of great significance. In this study, bioinformatics analysis and our results showed that miR-96 could directly bind to the 3UTR region of BCR-ABL1 to regulate fusion protein expression, thereby regulating its downstream signaling pathway ...
RNA binding proteins: pathways to blastic transformation. RNA binding proteins play an essential role in RNA metabolism because they regulate the mRNA fate from the active site of transcription to that of translation (17). In fact, nuclear RNA binding proteins, involved in the regulation of transcription, interact with the nascent pre-mRNA when genes are actively transcribed by RNA polymerase II. Following synthesis, other RNA binding proteins prepare the pre-mRNA for cytoplasmic export, which requires the activity of ribonucleoprotein capable of nucleocytoplasmic shuttling. In this initial journey, the mRNA becomes 5′-capped and polyadenylated and undergoes splicing. Once exported into the cytoplasm, the mature mRNA is transported to the translational machinery where, on association with ribosomes, it is decoded and used several times as a template for protein synthesis. During the entire process, the mRNA is not naked but different RNA binding proteins take turn and bind to regulatory ...
Chronic myelogenous leukemia (CML) is the type of cancer of the blood cells, deadly because it progresses more slowly than the acute forms of leukemia. A lot of white cells, known as granulocytes, are produced by the bone marrow, gradually crowding the bone marrow, and interfering with the normal production of blood cells. This is the forum for discussing anything related to this health condition
Chronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and oth
An established second-line drug for chronic myelogenous leukemia has high response rates when given to newly diagnosed patients as their first therapy for the disease, according to early results from...
The 3 phases of chronic myelogenous leukemia (CML), as defined by the World Health Organization (WHO),{ref1}{ref2} are listed below. Table. Phases of Chronic MyelogenousCML phase WHO defini... more
Keep up to date with the latest Chronic myelogenous leukemia (CML) information from Patient Power. Join our newsletter to be the first to find out whats new.
City of Hope researchers may have discovered a more effective treatment for patients with chronic myelogenous leukemia (CML) according to a study published in Nature Medicine.
Chronic Myelogenous Leukemia is a cancer of the blood and bone marrow. Learn about the risk factors, symptoms, diagnosis and treatment at UVA.
Question - Menopausal due to chronic myelogenous leukemia. Diagnosed with fluid in cyst. Will it lead to cancer?. Ask a Doctor about when and why Ultra sound is advised, Ask an Oncologist
View the most common signs and symptoms of Chronic Myelogenous Leukemia that you need to know about. Learn how it is diagnosed and find helpful books and resources.
Established from the pleural effusion of a 32-year-old woman with Philadelphia chromosome-positive CML in blast crisis in 1981; described to contain the t(9;22) leading to BCR-ABL1 e13-a2 (b2-a2) fusion gene and a p53 ...
During the course of chronic myeloid leukemia (CML) progression to blast crisis (BC) is thought to be caused by genetic instability such as cytogenetic aberrations in addition to the translocation t(9;22)(q34;q11). We have shown previously that major route ACA indicate an unfavorable outcome (Fabarius et al., Blood 2011). We now investigate whether there is a correlation in time between...
While this type of blood cancer is more common in adults, it affects children, too. Thanks to advances in therapy, most kids with CML can be cured.
The above dynamics work aggressively against traditional empirical management decision processes. Decisions must be made quickly with limited and often incorrect information.. A crisis is not business as usual. A crisis is business as unusual.. Crises have a short duration, but have consequences that can determine the viability of a business or organization for years to come. If you are explaining, you are losing.. Crises have impacts - for good and bad. Every crisis starts with a combination of opportunity and danger. Where the risk/crisis conundrum balances depends upon your initial critical decisions, your crisis communications, your monitoring of events, and your adjustments made to strategy and actions as events develop. Your companys reputation, brand, legacy, and profitability hang in the balance in a crisis. Crises are personal. Every crisis is a human crisis. It is your company. It is your people. It is your brand. It is your reputation. It is your career. Doing the wrong thing or ...
Description Mental Survival Guide. From the general crisis to the personal crisis is the book that aims to fortify the reader with the weapons necessary to defeat any crisis that dares to provoke him/her in a moment of his/her existence. It involves a practical approach to the phenomena triggered by...
Crisis chat lines do exist for those dont feel comfortable talking to a crisis counselor by phone. Here are 3 crisis chat lines you can try.
Assign 9863 for CML in 2008. The 2010 diagnosis is the same histology. Per the Hematopoietic database, chronic and accelerated phase are alternate names. This is the same primary per Rule M2. Blast phase (crisis) is also an alternate name for CML, which makes the 2012 diagnosis the same primary per Rule M2. As you noted, not all histologies have transformations. If a transformation is not listed, rules M8-M13 do not apply. For these types of cases, use M15 and use the multiple primaries calculator. ...
Case Study 4 ± Crisis Blown Over Ques 1. Do you think that the Bangalore-based company had practiced participative management? Answer. During such a crisis
The euro zone sovereign debt crisis has eased in recent weeks, ECB Governing Council member Athanasios Orphanides said on Saturday, adding more needed to be done to convince markets the euro zone had an effective crisis handling mechanism in place.
The brutal stabbing of Pietermaritzburg businessman Ashraf Mohideen (57) at the behest of his son and the killers he hired, has thrown his family into crisis and caused his business to close down.
With the proportion of over 65s on the increase, Britain is facing its biggest ever crisis when it comes to care of the elderly. And without the money to resolve the issue, could technology be the sav...
Considering the political organization of society at large, Chinas tackling of crisis by initial indifference to threat and suppression of facts & figure...
CIOs continue to adapt to the new normal of the COVID-19 world, reworking previous plans and reprioritizing IT budgets. Here are five strategies CIOs should consider implementing to help their companies emerge stronger from the current crisis.
Kimtex, Krizi Fırsata Çevirip İhracat Şampiyonu Oldu Kimtex Turns the Crisis into an Opportunity and Becomes the Export Winner Ar-Ge ye büyük önem veren Kimtex in kendine özel tasarımlar gerçekleştirdikleri
A large contributor to our crime crisis in the United States involves drug-related charges, which could be greatly alleviated through rehab programs.
Suctioning is a procedure that can save even the most vulnerable lives. Here are four suction techniques to use in a time of crisis.
WASHINGTON (AP) - The standoff that partially shut down the U.S. government persisted with no sign of a breakthrough Tuesday, as the Democra…
世界宣明會是一個基督教救援及發展機構,一直以兒童為中心,致力為貧困孩子、家庭及社區帶來轉機和希望。現時,宣明會的工作遍及全球近100個國家,援助不分宗教、種族和性別。
A crisis from early-childhood-education to post-grad - 23 Jan, 2018 A crisis from early-childhood-education to post-grad Mark Wegierski If there is anything that left-liberals in Canada clearly and unequivocally understand ... ...
"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC News. Retrieved 3 June 2013 ... "Terror attack: Blast on Tel Aviv bus; 28 hurt". Ynet News. 21 November 2012. Retrieved 27 January 2013.. ... "Deprived and Endangered: Humanitarian Crisis in the Gaza Strip". Human Rights Watch. Retrieved 3 September 2014.. ... Hamas's military wing claimed responsibility for the blast, stating that it was in response to the killing of the boy.[170] ...
Warrior Crisis Deadline Blast! Greg S. Baisden, Jean-Paul Jennequin, Jacques Dutrey, Nick Hasted, and Brad Brooks. "NEWSWATCH ... Two of its stories were concluded in another Fleetway publication, Crisis. (Crisis itself folded a few months later.) The ... "Crisis Folds, Fleetway Merges," The Comics Journal #146 (Nov. 1991), p. 22. Rigby, Regie. "Fool Britannia: 'These I Have Loved ... After Revolver's cancellation, Dare and Happenstance and Kismet were completed in the pages of Crisis. Dare was collected into ...
Chronic myelogenous leukemia blast crisis. He had undergone several chemotherapy sessions since he was diagnosed the previous ...
"Blasts escalate Japan's nuclear crisis". World News Australia. 16 March 2011. Archived from the original on 7 April 2011. David ... While stepping-up monitoring of radiation levels on its own shores in face of the Fukushima nuclear power plant crisis, China, ... In response to the crisis, the Japanese government mobilized the Self-Defence Forces, while many countries sent search and ... The ministry excluded Fukushima from the results because of the ongoing nuclear crisis. The reconstruction of damaged areas in ...
"Blasts escalate Japan's nuclear crisis". World News Australia. 16 March 2011. Archived from the original on 7 April 2011. David ... "NEWS ANALYSIS: Japan crisis puts global nuclear expansion in doubt". Platts. 21 March 2011. "Nuclear power: When the steam ... A 2011 poll found that skepticism over nuclear power had grown in Sweden following Japan's nuclear crisis. 36 percent of ... Platts has reported that "the crisis at Japan's Fukushima nuclear plants has prompted leading energy-consuming countries to ...
"Lebanon's Deepening Economic Crisis Laid Bare by Beirut Blast". BloombergQuint. Retrieved 19 September 2020. "Lebanon Will ... The crisis became worse when the COVID-19 pandemic affected the Lebanese economy. In 2020, the country defaulted for the first ... The liquidity crisis also lead to a restriction on the withdrawals from US Dollar bank accounts. Depositors needed to preserve ... This economic crisis made Lebanon's gross domestic product fall to about $44 billion, which was about $55 billion the year ...
"Lebanese government in crisis as ministers resign after blast". The Washington Post. 2020-08-10. Retrieved 2020-08-10. "Paula ... "Lebanon's Kataeb Party says its three MPs resigning from parliament in wake of Beirut blast". August 8, 2020 - via www.reuters. ... "Politician Paula Yacoubian says she risks her life fighting Lebanese corruption and garbage crisis". Euronews. 13 September ...
Their inactivation is related with progression into blast crisis. BCR/ABL pathway could also active PI64K/Akt/STAT5 pathway ... Some new translocate case of BAL has been reported, such as t(15,17) and t(12,13). For t(15;17), the blasts with morphology of ... BAL is difficult to treat, most patients receive treatment based on the morphology of blasts and get AML or ALL induction ... Usually the chemotherapy is chosen according to the morphology of the blast (ALL or AML). A blood-forming stem-cell ...
"Blast on bus in heart of Tel Aviv". Ynet News. 21 November 2012. "Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. 21 ... During the operation, a bomb blast on a bus wounded at least 28 civilians, three seriously. This was described as a terrorist ... Serge Schmemann (5 March 2010). "Bombing in Israel:The Overview;4th Terror Blast in Israel Kills 14 at Mall in Tel Aviv; Nine- ... "BBC NEWS , Middle East , Fatal bus blast rocks Tel Aviv". BBC News. London: BBC. 19 September 2002. Schmemann, Serge (20 ...
"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. November 21, 2012. Retrieved November 21, 2012. "Hamas leader tells ... "Terror attack: Blast on Tel Aviv bus; 28 hurt". Ynet News. November 21, 2012. Retrieved November 21, 2012. "הפיצוץ בת"א: "חשבנו ...
"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. November 21, 2012. Retrieved November 21, 2012. Hamas to gain ... many Arab states that backed the coalition cut off funds to the PLO which brought the PLO to the brink of crisis. In the ...
Mroue, Bassem; Keller, Greg (10 September 2012). "Syria Crisis: Aleppo Car Bomb Blast Kills At Least 30". Huffington Post. ... The state news agency SANA reported the deaths of three Syrian troops as a result of a bomb blast, with an officer also ... "Syria crisis: Spooked by rebel gains, Jordan doubles down on Islamic State". The Christian Science Monitor. 4 May 2015. ... Peter Harling, from the International Crisis Group, told the AFP that the proportion of foreign fighters is currently very ...
Mroue, Bassem; Keller, Greg (10 September 2012). "Syria Crisis: Aleppo Car Bomb Blast Kills At Least 30". Huffington Post. ... "Syrian crisis". www.unicef.org. Retrieved 5 May 2020. Welle (www.dw.com), Deutsche. "5 million Syrian children in need due to ... Syrian Crisis. New York City, NY: UNICEF. [2] Burack, Cristina. 2020. 5 Million Syrian Children in Need Due to War. Germany: DW ... "Syria Crisis Fast Facts". www.unicef.org. Retrieved 5 May 2020. "Help Children in Syria". Save the Children. Retrieved 5 May ...
Mroue, Bassem; Keller, Gereg (10 September 2012). "Syria Crisis: Aleppo Car Bomb Blast Kills At Least 30". Huffington Post. ... During four hours of fighting rebels tried to blast holes in the walls of the mosque with RPGs before storming the site but ... "Syrian forces blast rebel-held districts of Aleppo, according to activists". Al Jazeera. 30 July 2012. Retrieved 29 July 2012. ... On 21 October, "a suicide car bomber" caused a blast in the New Syriac quarter wounding several people and damaging the Syrian- ...
CS1 maint: discouraged parameter (link) Hiyama, Hiroshi (15 March 2011). "Blasts, new fire escalate Japan's nuclear crisis". ... "Japan nuclear crisis: Meltdown at Fukushima Daiichi plant may now be inevitable". The New York Daily News. 17 March 2011. ... CS1 maint: discouraged parameter (link) "TEPCO: Unit No.4 blast due to hydrogen from Unit No.3". NHK. 16 May 2011. Archived ... According to TEPCO, this was the last remaining makeshift power switchboard at the plant, installed after the nuclear crisis. ...
Lippman, Daniel (April 21, 2020). "Democrats blast Trump team's handling of federal workers in coronavirus crisis". Politico. ...
"Nigeria's Boko Haram crisis: Jos blasts kill scores". BBC News. Retrieved 6 July 2015. "Boko Haram Is Suspected After Explosion ... The blast killed twelve people and wounded another one. The attack occurred at dawn and was attributed to Boko Haram although ... The blast killed at least 11 people. The attack occurred on 29 January in Gombi, Nigeria. 30 January - At least 86 people are ... "Blasts From Women Suicide Bombers Kill 4 in North Nigeria". ABC News. 28 February 2015. Archived from the original on 13 March ...
"Nigeria's Boko Haram crisis: Maiduguri blasts kill dozens". BBC. 21 September 2015. Retrieved 23 September 2015. KAYODE IDOWU ... "Boko Haram crisis: Nigeria fury over U.S. arms refusal". BBC News. 11 November 2014. Retrieved 12 November 2014. Eric Schmidt ( ... "Boko Haram crisis: Nigeria estimates Baga deaths at 150". BBC News. 12 January 2015. Samer Muscati (10 June 2015). "Anatomy of ... "Blasts kill 4, injure 18 in northeastern Nigeria, police say". CNBC. 23 March 2017. Retrieved 8 May 2020. CNN, Bukola Adebayo ( ...
"Syria crisis: Dozens killed by Aleppo university blasts". BBC News. 2013-01-15. Archived from the original on 2017-10-18. ... The blast struck a parking lot for a military intelligence complex. The 18 July 2012 Damascus bombing was an attack that killed ... April 29 - A blast next to former Interior Ministry building in Damascus killed six people. Syrian prime minister Wael al-Halqi ... "IS blasts kill more than 140 as US, Russia press Syria truce". Agence France-Presse, Yahoo News. 21 February 2016. Archived ...
"Nigeria's Boko Haram crisis: Maiduguri blasts kill dozens". BBC News. September 21, 2015. Retrieved September 21, 2015. ... "Dozens die in blasts in Borno state capital, Nigerian official says". Abuja, Nigeria: CBS News. Associated Press. September 22 ... "5 suicide blasts hit Nigerian city of Maiduguri, 54 killed". Yahoo News. March 7, 2015. Bukar Hussain (September 21, 2015). "85 ... Lanre Ola; Isaac Abrak; Alexis Akwagyiram & Julia Payne (September 22, 2015). "At least 80 people killed in bomb blasts in ...
"Israel-Gaza crisis: 'Bomb blast' on bus in Tel Aviv". BBC. 21 November 2012. Retrieved 21 November 2012.. ... During the operation, a bomb blast on a bus wounded at least 28 civilians, three seriously.[97][98][99][100] This was described ... "BBC NEWS , Middle East , Fatal bus blast rocks Tel Aviv". BBC News. London: BBC. 19 September 2002. Retrieved 16 October 2011. ... "Blast on bus in heart of Tel Aviv". Ynet News. 21 November 2012. Retrieved 21 November 2012.. ...
For example, presence of a chloroma is sufficient to indicate chronic myelogenous leukemia has entered its 'blast crisis' phase ... An unusual variation of acute myelogenous leukemia associated with 8;21 chromosomal translocation and blast expression of the ...
It is highly expressed in blast crisis transition of chronic myeloid leukemia. When overexpressed by transfection, NME3 ...
MacKinnon, Mark (16 August 2020). "Leaders fear crisis sparked by Beirut blast could lead to civil war". The Globe and Mail Inc ... After the crisis, a new government was formed, led by the popular former general Fuad Chehab. During the 1960s, Lebanon enjoyed ... In the months leading up to the protests there was an ever deepening foreign reserves liquidity crisis. Days before protests ... In his speech Nasrallah blasted UN Security-Council Resolution 1559, which calls for Hezbollah's militia to be disbanded, as ...
Christopher Zara (30 April 2016). "Vietnam Dead Fish Crisis: Critics Blast Formosa Plastics As Environmental Disaster ... The 2016 Vietnam marine life disaster was a water pollution crisis affecting Hà Tĩnh, Quảng Bình, Quảng Trị and Thừa Thiên-Huế ... Mai Ngoc Chau; Yu-Huay Sun (4 May 2016). "Fish Death Crisis Prompts Vietnam Waste Water Probe". Blooomberg. Retrieved 8 May ... "Vietnam Minister Apologizes For 'Confused' And 'Slow' Response to Fish Crisis". Radio Free Asia. 29 April 2016. Retrieved 8 May ...
Carrington, Damian (9 November 2020). "'Hypocrites and greenwash': Greta Thunberg blasts leaders over climate crisis". The ... How can I feel safe when I know we are in the greatest crisis in human history?" After the paper published her article, she was ... "The climate crisis doesn't pause," Neubauer said at a joint press conference with her fellow activists echoing her sentiment. ... "It's an existential crisis. Listen to scientists". BBC. 23 April 2019. Archived from the original on 14 August 2019. Retrieved ...
Hypocrites and greenwash': Greta Thunberg blasts leaders over climate crisis". The Guardian. 9 November 2020. Retrieved 10 ...
"BBC News - Syria crisis: Dozens killed by Aleppo university blasts". BBC News. Retrieved 13 December 2014. HWAIDA SAAD;RICK ... 2013 "US blames regime airstrikes for Aleppo University blasts". Al Jazeera Blogs. Retrieved 13 December 2014. "Explosions at ... Fantz, Ashley; Abdelaziz, Salma (17 January 2013). "Aleppo University student describes chaos, carnage after blasts". CNN. ...
CS1 maint: discouraged parameter (link) "Blasts escalate Japan's nuclear crisis". World News Australia. March 16, 2011. ... from the chemical manufacturing operations of the Army and its lessee Shell Chemicals company Nigeria gully erosion crisis, ...
UBLF was involved in bomb blasts, murders and Hostage Crises. Its conflict was against Indigenous Tribals and other Tribals of ...
The 2007-2008 global financial crisis caused a general decline in raw material and equipment prices, which somewhat lessened ...
Tilton returned to television in 1994 with a new show called Pastor Tilton, a show with an emphasis on "demon blasting" ... One plaintiff, Vivian Elliott, won $1.5 million in 1994 when it was discovered that a family crisis center for which she had ... quoted in Christianity In Crisis by Hank Hanegraaff, Harvest House Publishers, 1993, p. 347. ... quoted in Christianity in Crisis by Hank Hanegraaff, Harvest House Publishers, 1993, p. 348. ...
"US Democratic hopeful Kucinich meets Assad, blasts Bush". The Jerusalem Post. Retrieved 2007-09-10.. [permanent dead link] ... The Crisis of Growth Politics: Cleveland, Kucinich, and the Challenge of Urban Populism by Todd Swanstrom ISBN 978-0-87722-366- ... US Democratic hopeful Kucinich meets Assad, blasts Bush, The Jerusalem Post, September 6, 2007 ... Boy Mayor' Kucinich Took Charge in Utility Debt Crisis, From LA Times, January 23, 2003 ...
Unite also blasted BA of removing staff travel concessions, bonus payments and other benefits to all cabin crew who undertook ... In 2020, due to the crisis caused by the COVID-19 pandemic, British Airways had to reduce its 42,000-strong workforce by 12,000 ...
As Trunks, he is about to blast Goku at point-blank range, when Trunks takes control and redirects the blast. Because Baby is ... " / "A Hidden Crisis!? A Spacewrecked Ship and Mysterious Boy". Transcription: "Kakusareta Kiki!? Nanbasen to Nazo no Shōnen ... He turns back to kill Goku, but before he can, 18 starts firing energy blasts at him. While 17 is absorbing the blasts, Goku ... She hits the blast-off button before Goten can climb aboard. Now Goku, Trunks, and Pan begin their adventure as Goten can ...
"Hughes's wintry blast for the undertaker PM". The Sydney Morning Herald. 1 June 2002. Retrieved 14 February 2016.. ... During the preceding constitutional crisis, Gorton had denounced Fraser's actions in blocking supply in the Senate.[82] In the ... McEwen's shock declaration triggered a leadership crisis within the Liberal Party; even more significantly, it raised the ...
1998), Out of Crisis Came Decision, History of the War of Independence, Vol. IV, University Press of America, ISBN ... After breaking through the peripheral fortifications and cutting through barbed wire, they blasted through a protective law[ ... Britain, facing a deep economic crisis and heavily dependent on the United States, was facing a massive financial burden over ... Fraser, T. G., "A crisis of leadership: Weizmann and the Zionist reactions to the Peel Commission's proposals, 1937-38", ...
Michael W. Flamm, Law and Order: Street Crime, Civil Unrest, and the Crisis of Liberalism in the 1960s (2005). ... "his big gun to blast radical opposition."[138] White set "Americanism" as the alternative, warning, "The election will sustain ... Crisis of Conservatism?: The Republican Party, the Conservative Movement, and American Politics after Bush (Oxford UP, 2011). ... Joel D. Aberbach; Gillian Peele (2011). Crisis of Conservatism?: The Republican Party, the Conservative Movement, and American ...
... was posthumously awarded the Edward Medal for trying to extinguish the fire that caused the blast.[127] The same year, on 13 ... the theatre suffered a financial crisis and closed. After years of disuse, it has been converted to a public house.[146] The ...
He is soon released however when Libra summons a boom tube for him at the behest of the Human Flame (See: Final Crisis). ... Metallo - Burned through by Martian Manhunter's eye blasts. Suffers the blue screen of death. Hyena - Shot in the head by a ... Tie-ins to the series have occurred in Countdown to Final Crisis (which details Piper and Trickster's continual evasion of ... General Immortus later appeared alive in "Final Crisis Aftermath: Run", but made reference to his seeming demise as a near- ...
... and Crow to stuff him into an airlock and blast him out of the ship and into space. Timmy's appearance was a parody of the evil ... giving Crow a brief identity crisis until Joel revealed he built Crow specifically to play this joke on him. Crow is also ...
Full Blast Productions. p. 13. ISBN 978-0-9784738-4-6. .. *^ Daniel Franklin; Michael J. Baun (1995). Political culture and ... Graham Fraser (2007). Sorry, I Don't Speak French: Confronting the Canadian Crisis That Won't Go Away. Random House Digital, ... Dominique Clift (1982). Quebec nationalism in crisis. McGill-Queen's University Press. pp. 106-108. ISBN 978-0-7735-0383-0. .. ... conscription crises highlighted the considerable rift along ethnic lines between Anglophones and Francophones.[22] As a result ...
"Separate blasts at three HDP buildings in Istanbul". World Bulletin. 17 December 2016.. ... "HDP: Turkish-Kurdish solution process has passed Kobani crisis". Retrieved 7 June 2015.. ...
ISBN 0-674-39731-2, The Crisis Under Gaius Caligula, pages 254-256: "The reign of Gaius Caligula (37-41) witnessed the first ... How burned, how blasted must our portion be,. If seed like this is withered in its soil. ... ... "Crisis under Caligula" (37-41) was the "first open break between Rome and the Jews".[50] Meanwhile, the Kitos War led to the ...
The crisis of British heavy rock giants left space for the rise of other rock bands in the mid-1970s,[21] including Queen,[22] ... Each of these bands was in crisis in the mid-to-late 1970s: Led Zeppelin were plagued by discord and personal tragedies and had ...
Main article: Crisis of the Late Middle Ages. The first years of the 14th century were marked by famines, culminating in the ... The blast furnace appeared around 1350 in Sweden, increasing the quantity of iron produced and improving its quality.[325] The ... and external pressure on the frontiers combined to create the Crisis of the Third Century, with emperors coming to the throne ...
Through the 1980s and 1990s, metalcore was mostly an underground phenomenon;[269] pioneering bands include Earth Crisis,[270][ ... Bathory inspired the Viking metal and folk metal movements and Immortal brought blast beats to the fore. Some bands in the ... In the 2000s decade, metal tempos range from slow ballad tempos (quarter note = 60 beats per minute) to extremely fast blast ... style blast beats. Frequent tempo and time signature changes and syncopation are also typical.[225] ...
During the global financial crisis of 2007-2010, Wyden voted against the financial bailouts backed by the Bush administration.[ ... "Wyden, Merkley blast Trump's pick of Kavanaugh". ktvz.com. July 9, 2018.. ... Wyden Issues Statement on Administration Proposal to Address Financial Crisis Archived March 4, 2010, at the Wayback Machine. ... Ailen Darling, "Wyden Supports Obama's Efforts in Libya's "Humanitarian Crisis' Archived March 3, 2016, at the Wayback Machine ...
See also: Debriefing § Crisis intervention. Trauma-exposed individuals often receive treatment called psychological debriefing ...
It was just days after Aaron Swartz' death, and I was having a crisis of conscience about publishing in a journal that was not ... "Publishers Blast New Open Access Bill, FASTR". Publishers Weekly. Archived from the original on 17 October 2013. Retrieved 17 ... Publishers have, in the past, lifted embargo periods for specific research topics in times of humanitarian crises, or have been ... "crisis of conscience about publishing in a journal that was not open access" after the death of Aaron Swartz.[133][134] ...
Journal of Risk Analysis and Crisis Response. 3 (1): 3-12. doi:10.2991/jrarc.2013.3.1.1.. ... Space-Time (BLAST). *Massive Multiple-input multiple-output (MIMO). *Reconfiguration. *Spread spectrum ... https://www.theguardian.com/science/2017/jul/29/infertility-crisis-sperm-counts-halved ...
One person was killed and four injured, one seriously, in a blast at the Marcoule Nuclear Site. The explosion took place in a ... "Fukushima Crisis Worse for Atomic Power Than Chernobyl, UBS Says". Bloomberg Businessweek ...
A review in The Times praised the book as a "powerful counter-blast against the monstrous regiment of 'useful idiots'" who have ... Beginning in January 2013, Seymour focused his blog on an internal crisis involving allegations of rape committed by a (now ... and began using the original blog to convey a more thorough account of the party's crisis than hitherto.[13] Writing in The ... "an excellent antidote to the propagandists of the crisis of our times", and a later review in The Independent by the policy ...
... "blast crisis" of CML. Medical imaging (such as ultrasound or CT scanning) can find invasion of other organs commonly the lung, ... Bone pain, joint pain (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow ... Monitoring initial response to treatment is important as failure to show clearance of blood or bone marrow blasts within the ... Reduce leukemic blasts in the bone marrow to ,5% and eliminate tumor cells from blood ...
"Argentina, Brazil leaders blast 'dictatorship' in Venezuela". France 24. 16 January 2019. Retrieved 4 March 2019.. ... "De banquete en banquete: Los "rojitos" que no escatiman a la hora de comer pese a la crisis". El Cooperate (in Spanish). 22 ... "Canada sanctions 40 Venezuelans with links to political, economic crisis". The Globe and Mail. 22 September 2017. Retrieved 22 ... "La ostentosa fiesta navideña del TSJ en medio de la crisis más grande del país". NTN24. 15 December 2018. Retrieved 11 May 2019 ...
Police gas and blast bombs killed many animals as well. Stray dogs, cats and birds in particular have died of heart attacks or ... Reporters without Borders, 11 June 2013, Journalists scapegoated in "Occupy Gezi" crisis ...
Relman, Arnold S. (2006). "Book Review: Crisis of Abundance: Rethinking How We Pay for Health Care". New England Journal of ... "Minister blasted over A&E target". BBC News. Archived from the original on October 30, 2007. Retrieved May 23, 2010 ... Economist Arnold Kling attributes the present cost crisis mainly to the practice of what he calls premium medicine, which ... "Giuliani in blast at the NHS". Mirror.co.uk. Archived from the original on June 5, 2011. ...
Hubbell, Richtmyer; Marc Newman (2000). Potomac Diary: A Soldier's Account of the Capital in Crisis, 1864-1865. Arcadia Books. ... Muzzle Blasts magazine. pp. 28-37. Archived from the original (PDF) on 14 April 2019. Retrieved 14 April 2019.. ...
Molecular characteristics of chronic myelogenous leukemia in blast crisis.. Blick M, Romero P, Talpaz M, Kurzrock R, Shtalrid M ...
... for alleged lack of urgency in the consideration and resolution of crises in the judiciary. ... The crisis reached a head last week when President Muhammadu Buhari suspended the Chief Justice of Nigeria, Walter Onnoghen, ... Speaking on the ongoing crisis, the NADL condemned the investigation of both the suspended CJN and acting CJN by the NJC. ... NADL called on political power holders and interest groups to stop politicising the crisis. I said the "clash of power" is ...
Gene context of Blast Crisis. *Four of 13 BCR/ABL transgenic founders developed a chronic MPD, but only one progressed to blast ... Disease relevance of Blast Crisis. *Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic ... Furthermore, most of the blast cells from patients in CML blast crisis, which are usually resistant to IFN-alpha therapy, ... to detect blast cells in CML crisis and also has the capability to detect PCNA in other cells associated with blast crisis [7]. ...
Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis.. Uchida T1, Kitaura J1, ... We have previously shown that elevated expression of Hairy enhancer of split 1 (Hes1) contributes to blast crisis transition in ... Thus, we have established mouse models of FIP1L1-PDGFRA-positive leukemia in myeloid blast crisis, which will help elucidate ... marrow cells expressing both Hes1 and FIP1L1-PDGFRα developed acute leukemia characterized by an expansion of myeloid blasts ...
Top doctors, health critics blast Health Minister Eric Hoskins for stem cell transplant crisis. ... minister Eric Hoskins drew heat from fellow doctors and political peers on Wednesday over Ontarios stem cell transplant crisis ...
A new study using CML in blast crisis cells has identified existing anticancer agents that may provide benefit to patients with ... A new study using CML in blast crisis cells has identified existing anticancer agents that may provide benefit to patients with ... A new study using chronic myeloid leukemia in blast crisis (CML BC) cells has identified existing anticancer agents that may ... "Despite the treatment breakthroughs in chronic phase CML, advanced phase and blast crisis remain a therapeutic challenge," ...
... "blast crisis." Blast crisis of CML is an ominous clinical event that can further be divided based on the site of origin: ... fewer patients are progressing to the accelerated phase and blast crisis. Once blast crisis in CML has been diagnosed, an ... Extramedullary blast crisis is extremely rare and is defined as the development of extramedullary blasts infiltration ... R. Hehlmann, "How I treat CML blast crisis," Blood, vol. 120, no. 4, pp. 737-747, 2012. View at Publisher · View at Google ...
Definition of blast crisis. Comparisons like this largely depend on the definition of BC and thereby on the time of its ... Blast crisis (BC) is the sword of Damocles hanging over every patient with chronic myeloid leukemia (CML). In the past, CML ... Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004; 351:657-67. Google ... The biology of CML blast crisis. Hematology Am Soc Hematol Educ Program. 2007;384-91. Google Scholar ...
Catholic League Blasted on Twitter for Dismissing Churchs Sexual Abuse Crisis as Total Myth. by Ken Meyer , Aug 17th, 2018, ... There is no on-going crisis-its a total myth. In fact, there is no institution, private or public, that has less of a problem ... who made the counterargument that the media was trying to sensationalize a false crisis based on an inconclusive report. Heres ...
... Member Center:*Create ... Arctic Blast leaves Red Cross in blood shortage crisis. time.prefixdate:before{content:Posted: ;}time.prefixdate:before{ ... Those cancellations have left the Red Cross in a blood shortage crisis. Area residents are encouraged to donate blood if ...
Blast phase of chronic myelogenous leukaemia (CML), which can be discovered incidentally on FBC or in assessment of patients ... Blast crisis refers to the transformation of chronic myelogenous leukaemia (CML) from the chronic or accelerated phase to blast ... Diagnosis of the blast phase of CML is based on percentage of blasts in peripheral smear or bone marrow. ... no remission achieved or recurrence of blast crisis after stem cell transplant. ...
Leukemic blasts will cause pseudohypoxemia on ABG (so-called leukocyte larceny) due to continued oxygen consumption in the ABG ... HU is a well-tolerated oral option for therapy that has demonstrated effectiveness in blast count reduction. This should be ... It is exceedingly effective in reducing the circulating blasts by removing circulating WBCs and reinfusing leukocyte-depleted ... It is exceedingly effective in reducing the circulating blasts by removing circulating WBCs and reinfusing leukocyte-depleted ...
Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three ... Blast Crisis*. Bone Marrow / pathology. Cell Lineage*. Humans. In Situ Hybridization, Fluorescence. Leukemia, B-Cell / ... Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid. ... Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three ...
Isolated Ocular Manifestation of Relapsed Chronic Myelogenous Leukemia Presenting as Myeloid Blast Crisis in a Patient on ... We describe a unique case of CML relapse with blast phase involving the eye. A 66-year-old man with a known diagnosis of CML on ... Blast phase in chronic myelogenous leukemia (CML) has rarely been reported to involve extramedullary sites like skin, lymph ... The blasts expressed CD34, aberrant TdT, and a myeloid phenotype (CD13, CD33, and CD117). Fluorescence in situ hybridization ( ...
Patient with Philadelphia chromosome positive CML in myeloid blast crisis is defined by the presence of ≥ 30% blasts in the ... Patient with Philadelphia chromosome positive CML in first blast crisis or first accelerated phase:. * AP-CML is defined by the ... CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Drug: Ponatinib Drug: ... Blast Crisis. Neoplasms by Histologic Type. Neoplasms. Myeloproliferative Disorders. Bone Marrow Diseases. Hematologic Diseases ...
The BCR-ABL tyrosine kinase inhibitor STI571 is well tolerated and has substantial activity in the blast crises of CML and in ... 38 patients had a myeloid blast crisis and 20 had ALL or a lymphoid blast crisis. Treatment was given orally at daily doses ... Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute ... All but one patient with a lymphoid blast crisis or ALL has relapsed. The most frequent adverse effects were nausea, vomiting, ...
... called blast crisis (BC), which involves aggressive proliferation of immature blast cells. The frequent appearances of ... Karyotype abnormalities and their clinical significance in blast crisis of chronic myeloid leukemia. J Mol Med 1997;75:836-838. ... To identify gene(s) whose alteration by retrovirus insertion contributes to blast crisis of CML, p210BCR/ABL transgenic mice ... Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia ...
Cells from chronic myelogenous leukemia donors expressed this dual reactivity only at the stage of blast crisis. This type of ... and chronic myelogenous leukemia patients in blast crisis (CML-BC). Earlier studies demonstrated that nonhuman primate antisera ... of Normal and Leukemia-associated Antigens of Acute Myelomonocytic Leukemia and Chronic Myelogenous Leukemia in Blast Crisis. T ... of Normal and Leukemia-associated Antigens of Acute Myelomonocytic Leukemia and Chronic Myelogenous Leukemia in Blast Crisis ...
... troops may be fueling the militarys suicide crisis, according to a letter co-signed by 53 congressional members who are ... Are brain injuries from IED blasts causing the military suicide crisis? By U.S. News ... "Evidence has suggested that blast injuries, including but not limited to those causing damage to vision or hearing, can have a ... Traumatic brain injuries sustained by more than 200,000 U.S. troops may be fueling the militarys suicide crisis, according to ...
phase, accelerated phase or in blast crisis patients previously enrolled to. CAMN107A2109 trial in Poland and continuing the ... Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Previously Enrolled to ENACT ( ... Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Previously Enrolled to ENACT ( ... in blast crisis, accelerated phase and ch ...
... ... Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate.}, ... the clinical and genetic response to imatinib mesylate treatment of an ETV6/ABL1-positive CML patient diagnosed in blast crisis ... the clinical and genetic response to imatinib mesylate treatment of an ETV6/ABL1-positive CML patient diagnosed in blast crisis ...
COVID-19, the economic crisis, and the Beirut blast: what 2020 meant to the Lebanese health-care system ... Citation: Mjaess G; Karam A; Chebel R; Tayeh GA; Aoun F. COVID-19, the economic crisis, and the Beirut blast: what 2020 meant ... 8. Abouzeid M, Habib RR, Jabbour S, Mokdad AH, Nuwayhid I. Lebanons humanitarian crisis escalates after the Beirut blast. ... The economic crisis. Lebanon is facing its worst economic crisis since the civil war. This was accompanied by a subsequent ...
BCR-ABL1- and CBFB-MYH11-positive chronic myeloid leukemia presenting with primary blast crisis and marrow fibrosis. ... BCR-ABL1- and CBFB-MYH11-positive chronic myeloid leukemia presenting with primary blast crisis and marrow fibrosis ...
We report here a series of five patients seen at a single institution over a 10 year period who developed blast crisis as the ... The blast cells were myeloid in three cases and lymphoid in two. In one case the relapse may have occurred in cells of donor ... We report here a series of five patients seen at a single institution over a 10 year period who developed blast crisis as the ... Relapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia: a report of five ...
Prominent hematogone hyperplasia in BCR-ABL1-positive chronic myelogenous leukemia: Mimicking recurrent B-lymphoid blast crisis ... Mimicking recurrent B-lymphoid blast crisis. / Horna, Pedro; Pantazopoulos, Panagiotis; Lancet, Jeffrey E.; Moscinski, Lynn C ... Mimicking recurrent B-lymphoid blast crisis. In: Leukemia and Lymphoma. 2014 ; Vol. 55, No. 8. pp. 1952-1954. ... Mimicking recurrent B-lymphoid blast crisis",. author = "Pedro Horna and Panagiotis Pantazopoulos and Lancet, {Jeffrey E.} and ...
Democrats blast latest Trump crisis. But what will they do? High levels of cancer-causing chemical found in mint and menthol e- ...
Blast Crisis/pathology , Bone Marrow/pathology , Humans , India , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ... Blast Crisis / India Country/Region as subject: Asia Language: English Year: 1988 Type: Article ... Blast Crisis / India Country/Region as subject: Asia Language: English Year: 1988 Type: Article ... Blast crisis in chronic myeloid leukaemia. Blast crisis in chronic myeloid leukaemia. ...
Blast Crisis Language: English Year: 1990 Type: Article ... Blast Crisis Language: English Year: 1990 Type: Article ... Extramedullary blast crisis in chronic myelogenous leukaemia. Extramedullary blast crisis in chronic myelogenous leukaemia. ...
Blast. Crisis. /etiology. Blast. Crisis. /metabolism. Blast. Crisis. /. pathology. Blotting, Western. DNA Damage. Flow ... Blast. Crisis. -- blood. Blast. Crisis. -- pathology. Cell Proliferation. Growth Substances -- blood. Humans. Leukemia, Myeloid ... blast. crisis. induced by cooperation between BCR/ABL and NUP98/HOXA9.. Autorzy :. Dash, Ajeeta B. Pokaż więcej Index Terms :. ... blast. crisis. induced by cooperation between BCR/ABL and NUP98/HOXA9.. Index Terms :. Medicine and Health Sciences. Animals. ...
  • Whereas FIP1L1-PDGFRα alone induced acute T-cell leukemia or myeloproliferative neoplasms in mouse bone marrow transplantation models, mice transplanted with bone marrow cells expressing both Hes1 and FIP1L1-PDGFRα developed acute leukemia characterized by an expansion of myeloid blasts and leukemic cells without eosinophilic granules. (nih.gov)
  • In virtually all patients, the disease culminates into an acute leukemic phase, especially if untreated, termed "blast crisis. (hindawi.com)
  • Nonhuman primate antisera defining leukemia-associated and normal T- and B-lymphocyte-associated antigens were used to characterize serologically the cells from acute myelomonocytic leukemia (AMML) and chronic myelogenous leukemia patients in blast crisis (CML-BC). (aacrjournals.org)
  • Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia. (wroc.pl)
  • I. To determine the complete response rate (CR) of cladribine in combination with idarubicin and cytarabine (araC) in patients with acute myeloid leukemia (AML), high risk (HR) myelodysplastic syndrome (MDS), or myeloid blast phase of chronic myeloid leukemia (CML). (clinicaltrials.gov)
  • We have analyzed 21 hematologic malignancies (8 CML in blast crisis, 8 myelodysplastic syndromes [MDS], 2 acute myeloid leukemias, 2 chronic lymphocytic leukemias, and 1 acute lymphoblastic leukemia) with i(17q) by fluorescence in situ hybridization (FISH). (lu.se)
  • Because the p210BCR-ABL protein appears cytoplasmic in both chronic phase and blast crisis CML cells, as does the p190BCR-ABL in Ph1-positive acute leukemia, a change in subcellular location of Bcr-Abl proteins between cytoplasm and nucleus cannot explain the different spectrum of leukemias associated with p210 and p190, nor the transition from the chronic to the acute leukemia phenotype seen in CML. (nih.gov)
  • By six to seven years, a "very substantial" proportion of CML cases evolve to acute leukemia or blast crisis, Dr. Finn says. (cap.org)
  • Chronic lymphocytic leukemia (CLL) are commonly reported to progress into aggressive high grade lymphoma (Richter syndrome, RS) or acute leukemia (blast crisis). (frontiersin.org)
  • 38 patients had a myeloid blast crisis and 20 had ALL or a lymphoid blast crisis. (nih.gov)
  • Of 20 patients with a lymphoid blast crisis or ALL, 14 (70 percent) had a response, including 4 who had complete responses. (nih.gov)
  • All but one patient with a lymphoid blast crisis or ALL has relapsed. (nih.gov)
  • Using whole-exome and/or RNA sequencing of patients at chronic phase (CP, n = 49), myeloid blast crisis (MBC, n = 19), and lymphoid blast crisis (LBC, n = 20), we found 25 focal gene deletions and 14 fusions in 24 patients in BC. (sahmriresearch.org)
  • We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis. (elsevier.com)
  • This can develop at extramedullary sites rarely and is defined as the infiltration of blasts outside the bone marrow irrespective of proliferation of blasts within the bone marrow. (hindawi.com)
  • We aim to report an unusual clinical presentation characterized by Horner's syndrome, ipsilateral arm weakness, and cervical lymphadenopathy as the first signs of extramedullary blast crisis in a CML patient. (hindawi.com)
  • Blast crisis of CML is an ominous clinical event that can further be divided based on the site of origin: medullary or extramedullary [ 2 ]. (hindawi.com)
  • Extramedullary blast crisis is extremely rare and is defined as the development of extramedullary blasts infiltration irrespective of the proliferation of blasts in the bone marrow [ 3 ]. (hindawi.com)
  • First attempts at the definition of BC date back about 40 years.3 The generally used definition which underlies virtually all current clinical CML trials (including the ELN management recommendations)4 rests on at least 30% of blasts in blood or marrow and the demonstration of extramedullary blastic infiltrates. (haematologica.org)
  • 30% by MD Anderson Cancer Center and the International Bone Marrow Transplant Registry criteria) in the peripheral blood smear or the bone marrow, or the presence of an extramedullary accumulation of blast cells, or large foci or clusters of blasts in the bone marrow biopsy. (bmj.com)
  • Blast phase in chronic myelogenous leukemia (CML) has rarely been reported to involve extramedullary sites like skin, lymph nodes, and central nervous system. (hindawi.com)
  • Patient with Philadelphia chromosome positive CML in myeloid blast crisis is defined by the presence of ≥ 30% blasts in the bone marrow and/or peripheral blood or the presence of extramedullary disease. (clinicaltrials.gov)
  • Extramedullary blast crisis in chronic myelogenous leukaemia. (bvsalud.org)
  • A new study using CML in blast crisis cells has identified existing anticancer agents that may provide benefit to patients with this difficult-to-treat disease. (cancernetwork.com)
  • A new study using chronic myeloid leukemia in blast crisis (CML BC) cells has identified existing anticancer agents that may provide benefit to patients with this difficult-to-treat disease. (cancernetwork.com)
  • The study included three distinct CML cell lines representing blast phase disease, as well as mononuclear cells from three CML BC patients and nine healthy donors. (cancernetwork.com)
  • A subset of patients with hyperleukocytosis can develop the clinical condition of leukostasis, a life-threatening oncologic emergency where leukemia cells (typically but not always immature blasts) are thought to cause organ dysfunction by impairment of microvascular perfusion. (neurologyadvisor.com)
  • Histologic examination revealed diffuse involvement of choroid, iris, vitreous humor, and the optic nerve by blast cells. (hindawi.com)
  • Chronic myelogenous leukemia (CML) is a hematopoietic disorder originating from p210BCR/ABL -transformed stem cells, which begins as indolent chronic phase (CP) but progresses into fatal blast crisis (BC). (bloodjournal.org)
  • After several years' duration of the chronic phase, however, the disease inevitably accelerates and ultimately progresses to the terminal fatal stage, called blast crisis (BC), which involves aggressive proliferation of immature blast cells. (bloodjournal.org)
  • Cells from chronic myelogenous leukemia donors expressed this dual reactivity only at the stage of blast crisis. (aacrjournals.org)
  • The blast cells were myeloid in three cases and lymphoid in two. (semanticscholar.org)
  • Out of 27 patients with verified blast crisis, 6 showed markedly elevated enzyme activities in the leukemic blast cells. (elsevier.com)
  • The first test determines whether the blast phase involves myeloid or lymphoid blast cells. (lls.org)
  • This test is needed because the type of blast cells is a factor in the treatment decision. (lls.org)
  • The phases are based mainly on the number of immature white blood cells (blasts) in the blood or bone marrow. (cancer.org)
  • The blast cells have spread to tissues and organs beyond the bone marrow. (cancer.org)
  • Chronic Myeloid Leukemia-Bone MarrowMononuclear Cells are available in either the chronic phase or accelerated/blast crisis phase. (creative-bioarray.com)
  • In this study, we investigated the lineage of blast cells in CML-BC using immunophenotypic and genetic analyses and analyzed the prognostic significance of genotypic change in CML-BC. (elsevier.com)
  • According to a new study, ADAR1 activation represents a unique therapeutic vulnerability in leukemia stem cells, which can give rise to blast crisis in chronic myeloid leukemia. (pharmaceuticalintelligence.com)
  • Leukemia stem cells promote an aggressive, therapy-resistant form of disease called blast crisis. (pharmaceuticalintelligence.com)
  • To study ADAR1, the UCSD team used human blast crisis chronic myeloid leukemia (CML) cells in the lab, and mice transplanted with these cells, to determine the enzyme's role in governing leukemia stem cells. (pharmaceuticalintelligence.com)
  • Self-renewal of blast crisis CML cells was reduced by approximately 40% when treated with the small molecule called 8-Aza as compared to untreated cells. (pharmaceuticalintelligence.com)
  • Exposure of the patient's blast cells to E 2 in vitro resulted in cessation of cell growth following at least one mitosis after addition of the inducer as seen from the replacement of the large blasts by small CLL-like cells without definite signs of alteration of the differentiation status. (elsevier.com)
  • At this stage, over 50% of the cells in the bone marrow are immature malignant cells (also called blast cells or promelocytes). (encyclopedia.com)
  • A sample of blood is examined under a microscope to identify abnormal red cells - which are larger than healthy cells - and to count the number of mature cells and blasts present. (encyclopedia.com)
  • In recent years an ever increasing set of cell surface and other markers has been used to classify and subclassify leukemic blast cells. (springer.com)
  • The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (CP), which is characterized by expansion of functionally normal myeloid cells, followed by an accelerated phase (AP) and finally a more aggressive blast phase (BP), with loss of terminal differentiation capacity. (genome.jp)
  • Large clusters of blasts are seen in the bone marrow. (cancer.org)
  • Cancer red cell precursors predominate, myeloid blasts also are seen, and multinucleated red cell precursors are common. (encyclopedia.com)
  • If untreated, CML progresses into the rapidly fatal blast crisis CML (CML-BC), which is characterized by enhanced proliferation, increased survival, genomic instability, and suppression of differentiation of myeloid or lymphoid progenitors ( 1 , 2 ). (aacrjournals.org)
  • In canine chronic leukemias, blast crisis (mainly in myeloid) and Richter syndrome (transformation into a high grade lymphoma) (mainly in B-cell lymphocytic leukemia) have been reported. (frontiersin.org)
  • We describe a unique case of CML relapse with blast phase involving the eye. (hindawi.com)
  • Relapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia: a report of five cases. (semanticscholar.org)
  • We report here a series of five patients seen at a single institution over a 10 year period who developed blast crisis as the first sign of relapse after BMT for CML in chronic phase. (semanticscholar.org)
  • Molecular characteristics of chronic myelogenous leukemia in blast crisis. (nih.gov)
  • Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis. (nih.gov)
  • We have previously shown that elevated expression of Hairy enhancer of split 1 (Hes1) contributes to blast crisis transition in Bcr-Abl-positive chronic myelogenous leukemia. (nih.gov)
  • Thus, we have established mouse models of FIP1L1-PDGFRA-positive leukemia in myeloid blast crisis, which will help elucidate the pathogenesis of the disease and develop a new treatment for it. (nih.gov)
  • Chronic myelogenous leukemia (CML) blast crisis is an ominous clinical event that is challenging to treat. (hindawi.com)
  • Blast crisis (BC) is the sword of Damocles hanging over every patient with chronic myeloid leukemia (CML). (haematologica.org)
  • Chronic myelogenous leukemia showing biphenotypic blast crisis followed by lineage switch to B lymphoblastic leukemia. (biomedsearch.com)
  • Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). (biomedsearch.com)
  • This project is strategy aiming to improve the survival of patients with chronic myelogenous leukemia in advanced phase and myeloid blast crisis. (clinicaltrials.gov)
  • The basis of this strategy is to add the demethylating agent 5-Azacitidine to the tyrosine kinase inhibitor ponatinib and evaluate its activity in 2 cohorts of patients with either chronic myelogenous leukemia in advanced phase or myeloid blast crisis. (clinicaltrials.gov)
  • IMSEAR at SEARO: Testicular involvement in blast crisis of chronic myeloid leukemia. (who.int)
  • Chronic myelogenous leukemia (CML) may transform into blast crisis (BC) if not properly treated. (elsevier.com)
  • FDA¿s authorization of Gleevec covered its use as oral therapy for treating patients with chronic myeloid leukemia (CML) in the accelerated phase of blast crisis, or in chronic phase after failure of interferon-alpha treatment. (bioworld.com)
  • Blast crisis of chronic myeloid leukemia is associated with poor survival and the accumulation of genomic lesions. (sahmriresearch.org)
  • Also, it indicated, in a model of blast crisis (BC) CML, that combined JAK2 and BCR-ABL1 inhibition prevents leukemia stem cell self-renewal commensurate with ADAR1 downregulation. (pharmaceuticalintelligence.com)
  • Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation, remain formidable challenges for chronic myeloid leukemia (CML). (elsevier.com)
  • Bcr-abl positive blast crisis of chronic myeloid leukemia emerging in a case of metastatic colorectal cancer 3 months after completion of an 8-month course of cetuximab and irinotecan. (pubfacts.com)
  • Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. (scienceopen.com)
  • Altered mRNA metabolism is a feature of many cancers including blast crisis chronic myelogenous leukemia. (aacrjournals.org)
  • We also provide evidence that these studies not only advance our understanding on the molecular mechanisms contributing to tumor/leukemia emergence, maintenance, and/or progression but they also serve for the identification of novel molecular targets useful for the development of alternative therapies for imatinib-resistant and blast crisis chronic myelogenous leukemia and, perhaps, for other cancers characterized by similar alterations in the mRNA metabolism. (aacrjournals.org)
  • Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid. (biomedsearch.com)
  • 1. Imatinib - resistant or - intolerant Philadelphia chromosome-positive CML in chronic phase, accelerated phase or in blast crisis patients previously enrolled to CAMN107A2109 trial in Poland and continuing the treatment with nilotinib at the time of enrollment for this trial. (knowcancer.com)
  • Diagnosis of the blast phase of CML is based on percentage of blasts in peripheral smear or bone marrow. (bmj.com)
  • The outlook for someone with CML depends on the phase of the disease and the amount of blasts in the bone marrow, as well as other factors like the age of the patient, blood counts, and if the spleen is enlarged. (cancer.org)
  • Patients in the chronic phase typically have less than 10% blasts in their blood or bone marrow samples. (cancer.org)
  • Bone marrow and/or blood samples from a patient in this phase have 20% or more blasts. (cancer.org)
  • The blasts may have spread outside the blood or marrow to other tissues. (nccn.org)
  • Lebanon suffered a hattrick of simultaneous events during 2020 - the economic crisis, the Beirut blast and the COVID-19 pandemic - which sorely tested its ability to orchestrate recovery efforts. (who.int)
  • We report an unusual clinical presentation heralding blast crisis transformation in a CML patient, characterized by cervical lymphadenopathy, cervicothoracic paraspinal chloroma with leukemic infiltration of the brachial plexus causing left Horner's syndrome, and ipsilateral symptomatic arm involvement. (hindawi.com)
  • Blast crisis refers to the transformation of chronic myelogenous leukaemia (CML) from the chronic or accelerated phase to blast phase. (bmj.com)
  • We used two clones, expressing low and high levels of Bcr-Abl, referring to the chronic phase and blast crisis of CML, respectively. (aacrjournals.org)
  • Transplant may also be recommended for people who are diagnosed in accelerated phase or blast crisis. (medlineplus.gov)
  • Younger patients may present with a more aggressive form of CML, such as in accelerated phase or blast crisis. (prezi.com)
  • Another vital aspect of crisis leadership is obtaining the facts before speaking and choosing words carefully-both areas where Mr. Trump struggles. (wsj.com)
  • Genomic instability is common in blast crisis and may contribute to malignant progression and resistance to cell death ( 2 - 5 ). (aacrjournals.org)
  • While fusion of c-ABL and BCR is believed to be the primary cause of the chronic phase of CML, progression to blast crisis requires other molecular changes. (genome.jp)
  • Here we describe the clinical and genetic response to imatinib mesylate treatment of an ETV6/ABL1-positive CML patient diagnosed in blast crisis (BC). (lu.se)
  • Health minister Eric Hoskins drew heat from fellow doctors and political peers on Wednesday over Ontario's stem cell transplant crisis, which has seen under-funded hospital programs rationing life-saving treatment as patients are dying on unacceptably long wait lists. (thestar.com)
  • It has been shown that a change of definition, e.g. to a blast count of 20%, would regroup up to 10% of patients. (haematologica.org)
  • Patients with 20-29% blasts, currently classified as accelerated phase, had a significantly better prognosis than patients with more than 30% blasts.5 Most clinicians and trialists, therefore, will likely stick with the definition for which they have the most data, observe ongoing research closely, and wait for additional evidence on the biology of BC for a new evidence based definition. (haematologica.org)
  • Blast phase of chronic myelogenous leukaemia (CML), which can be discovered incidentally on FBC or in assessment of patients with symptoms and signs such as fever, fatigue, weight loss, anaemia, thrombocytopenia, or splenomegaly. (bmj.com)
  • On the basis of the substantial activity of the inhibitor in patients in the chronic phase, we evaluated STI571 (formerly known as CGP 57148B), a specific inhibitor of the BCR-ABL tyrosine kinase, in patients who had CML in blast crisis and in patients with ALL who had the Ph chromosome. (nih.gov)
  • Seven patients with a myeloid blast crisis continue to receive treatment and remain in remission from 101 to 349 days after starting the treatment. (nih.gov)
  • Patients are often unable to afford medical services impacted by the economic crisis, with more than 40% of the Lebanese population now living below the poverty line, especially in underserved areas (5). (who.int)
  • Given the massive flow of patients during such a short time frame, hospitals used up two months' stock of medical supplies within days of the blast (10). (who.int)
  • In 54 patients with suspected or established blast crisis, TdT determinations were performed. (elsevier.com)
  • Treatment at a specialized center with doctors who have expertise in treating CML patients is recommended for patients in the blast phase of the disease. (lls.org)
  • We¿ve also known that when patients are in the end stage of the disease, which goes by the term blast crisis,¿ that there are numerous additional genetic hits that the cancerous cell has accumulated. (bioworld.com)
  • As reported in Science , Sawyers described the clinical analysis of patients who had relapsed from early stage chronic CML to the late-stage blast crisis: ¿We examined the status of BCR-ABL in nine blast-crisis patients who had developed resistance to Gleevec. (bioworld.com)
  • I. To determine the overall response rate (ORR) of cladribine in combination with idarubicin and araC in patients with AML, HR MDS, or myeloid blast phase of CML. (clinicaltrials.gov)
  • To assess the duration of response to the combination in patients with AML, HR MDS, or myeloid blast phase of CML. (clinicaltrials.gov)
  • No patients progressed to advanced phase/blast crisis. (novartis.com)
  • This system considers the person's age, the percentage of blasts in the blood, the size of the spleen, and the number of platelets. (cancer.org)
  • IMSEAR at SEARO: Blast crisis in chronic myeloid leukaemia. (who.int)
  • The frequent appearances of additional chromosomal abnormalities in the blast phase strongly suggest that superimposed genetic events would account for the disease evolution, 8 but the underlying molecular mechanism(s) has remained largely unknown. (bloodjournal.org)
  • Lebanon is facing its worst economic crisis since the civil war. (who.int)
  • Those cancellations have left the Red Cross in a blood shortage crisis. (wlox.com)
  • A year later, he began to appear unexplained high fever with ineffective antibiotic treatment and bone morrow and blood tests indicated blast crisis. (springeropen.com)
  • Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate. (lu.se)
  • WASHINGTON - Environmental champion Greta Thunberg assailed powerful politicians on Thursday for 'ignoring' climate change, as she demanded an end to fossil fuel subsidies and implored the current generation of leaders to take the crisis more seriously. (bangkokpost.com)

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