Tumor Virus Infections
A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.
Simian virus 40
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.
Influenza A Virus, H1N1 Subtype
Cell Transformation, Viral
Influenza A Virus, H5N1 Subtype
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.
Influenza A Virus, H3N2 Subtype
Hepatitis B virus
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
West Nile virus
A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE). It can infect birds and mammals. In humans, it is seen most frequently in Africa, Asia, and Europe presenting as a silent infection or undifferentiated fever (WEST NILE FEVER). The virus appeared in North America for the first time in 1999. It is transmitted mainly by CULEX spp mosquitoes which feed primarily on birds, but it can also be carried by the Asian Tiger mosquito, AEDES albopictus, which feeds mainly on mammals.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Respiratory Syncytial Viruses
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Cytopathogenic Effect, Viral
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Virus Physiological Processes
Vesicular stomatitis Indiana virus
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
Hemagglutinin Glycoproteins, Influenza Virus
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
Simian immunodeficiency virus
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Parainfluenza Virus 1, Human
Hepatitis A virus
Avian Sarcoma Viruses
Viral Plaque Assay
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
DNA Restriction Enzymes
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Large-Conductance Calcium-Activated Potassium Channels
Avian leukosis virus
Gene Expression Regulation, Viral
Moloney murine leukemia virus
Leukoencephalopathy, Progressive Multifocal
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Nucleic Acid Hybridization
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Yellow fever virus
Tobacco Mosaic Virus
Respiratory Syncytial Virus Infections
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Respiratory Syncytial Virus, Human
Enhancer Elements, Genetic
The type species in the genus NOROVIRUS, first isolated in 1968 from the stools of school children in Norwalk, Ohio, who were suffering from GASTROENTERITIS. The virions are non-enveloped spherical particles containing a single protein. Multiple strains are named after the places where outbreaks have occurred.
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Herpesvirus 1, Human
The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.
Epstein-Barr Virus Infections
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Herpesvirus 4, Human
Encephalitis Viruses, Tick-Borne
Parainfluenza Virus 3, Human
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Viral Structural Proteins
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Leukemia Virus, Feline
Foot-and-Mouth Disease Virus
Amino Acid Sequence
Porcine respiratory and reproductive syndrome virus
Sequence Analysis, DNA
Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
Sensitivity and Specificity
Sequence Homology, Nucleic Acid
Human T-lymphotropic virus 1
A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).
Diarrhea Viruses, Bovine Viral
A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes.
Hepatitis E virus
Friend murine leukemia virus
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
Mammary Tumor Virus, Mouse
Viral Core Proteins
Sarcoma Viruses, Murine
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Influenza A Virus, H7N7 Subtype
Hemagglutination Inhibition Tests
Leukemia Virus, Bovine
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Open Reading Frames
Cell Transformation, Neoplastic
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Lymphocytic choriomeningitis virus
The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.
Regulatory Sequences, Nucleic Acid
Borna disease virus
A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
Distemper Virus, Canine
Gene Products, gag
Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
Viral Fusion Proteins
Influenza A Virus, H7N9 Subtype
Hepatitis Delta Virus
Herpesvirus 3, Human
RNA-Directed DNA Polymerase
African Swine Fever Virus
A possible contributory role of BK virus infection in neuroblastoma development. (1/481)The tumor suppressor protein p53 is aberrantly localized to the cytoplasm of neuroblastoma cells, compromising the suppressor function of this protein. Such tumors are experimentally induced in transgenic mice expressing the large tumor (T) antigen of polyomaviruses. The oncogenic mechanisms of T antigen include complex formation with, and inactivation of, the tumor suppressor protein p53. Samples from 18 human neuroblastomas and five normal human adrenal glands were examined. BK virus DNA was detected in all neuroblastomas and none of five normal adrenal glands by PCR. Using DNA in situ hybridization, polyomaviral DNA was found in the tumor cells of 17 of 18 neuroblastomas, but in none of five adrenal medullas. Expression of the large T antigen was detected in the tumor cells of 16 of 18 neuroblastomas, but in none of the five adrenal medullas. By double immunostaining BK virus T antigen and p53 was colocalized to the cytoplasm of the tumor cells. Immunoprecipitation revealed binding between the two proteins. The presence and expression of BK virus in neuroblastomas, but not in normal adrenal medulla, and colocalization and binding to p53, suggest that this virus may play a contributory role in the development of this neoplasm. (+info)
Concerted expression of BK virus large T- and small t-antigens strongly enhances oestrogen receptor-mediated transcription. (2/481)Previous studies have shown that the human polyomavirus BK (BKV) genome contains an oestrogen response element (ERE). This isolated element binds its cognate receptor in vitro and can mediate 17beta-oestradiol-induced gene expression when linked to a heterologous promoter. The roles of the ERE- and the AP-1-binding sites in oestrogen receptor-directed transcription from the complete BKV promoter/enhancer (Dunlop strain) have been examined and the effects of the general co-activator CBP and large T- and small t-antigens on oestrogen receptor-mediated transcription have been investigated. A constitutive activated oestrogen receptor stimulated BKV promoter activity in HeLa cells. Mutations in either the ERE- or the AP-1-binding sites did not impair oestrogen receptor-induced activation of the BKV Dunlop promoter, while mutations in both binding motifs almost completely abolished oestrogen receptor-induced transcription. Simultaneous expression of large T- and small t-antigens strongly activated oestrogen receptor-mediated transcription. When expressed separately, only large T-antigen moderately stimulated oestrogen receptor-mediated transcription. The stimulatory effect of large T-antigen on the activity of the oestrogen receptor is probably indirect because no physical interaction between the two proteins was detected in a two-hybrid assay. Large T-antigen abrogated the synergistic effect on transcription between this nuclear receptor and the general co-activator CBP. The findings that the BKV early proteins amplify oestrogen receptor-mediated transcription may have important biological implications in individuals with raised oestrogen concentrations. (+info)
Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice. (3/481)To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridization revealed that the transgene is stably maintained in all organs of transgenic mice as a tandem insertion in a number of copies ranging from 5 to 20 per cell. In addition, tat and BKV RNA were expressed in all tissues. Transgenic mice developed three types of lesions: 1) tumors, 2) hyperplastic and dysplastic lesions, and 3) non-neoplastic lesions. Tumors of different histotypes, such as lymphomas, adenocarcinomas of skin glands, leiomyosarcomas, skin squamous cell carcinomas, hepatomas, hepatocarcinomas, and cavernous liver hemangiomas, developed in 29% of transgenic animals. The majority of tumors were malignant, invasive, and producing metastases. Conversely, tumors of only two histotypes (lymphomas and adenocarcinomas of skin glands) appeared in control mice. Hyperplastic and dysplastic lesions were more frequent in transgenic than in control mice and involved the skin or its adnexes, the liver and the rectum, indicating multiple targets for the activity of the transgene. Pyelonephritis, frequently complicated with hydronephrosis, inflammatory eye lesions, and amyloid depositions represented the most frequent non-neoplastic lesions detected in transgenic mice. Many of the pathological findings observed in this animal model are comparable to similar lesions appearing in AIDS patients, suggesting a relevant role for Tat in the pathogenesis of such lesions during the course of AIDS. (+info)
BK and JC viruses in patients with systemic lupus erythematosus: prevalent and persistent BK viruria, sequence stability of the viral regulatory regions, and nondetectable viremia. (4/481)A role for polyomaviruses in the pathogenesis of systemic lupus erythematosus (SLE) has been suggested. BK virus (BKV) and JC virus (JCV) were demonstrated in single urine specimens from 7 (16%) of 44 and 5 (11%) of 44 patients with SLE and 0/88 and 18 (21%) of 88 matched healthy controls, respectively. During a 1-year follow-up study, episodes of polyomaviruria were detected in 16 (80%) of 20 patients, BKV in 13, and JCV in 3 patients. A group of 12 (60%) of 20 patients demonstrated persistent or recurrent polyomaviruria, BKV viruria (n=9), or JCV viruria (n=3) in 180 (70%) of 256 specimens. Polyomaviruria was not significantly associated with immunosuppressive therapy. The BKV and JCV isolates revealed predominantly stable archetypal regulatory regions over 3 years, indicating viral persistence rather than reinfection as a cause for urinary shedding. The demonstration of nondetectable viremia and stable archetypal BKV and JCV noncoding control regions during persistent viruria argue against the urinary tract as a focus for the creation of rearranged regulatory region variants. (+info)
JC and BK virus sequences are not detectable in leukaemic samples from children with common acute lymphoblastic leukaemia. (5/481)Epidemiological evidence suggests that childhood leukaemia, and possibly common acute lymphoblastic leukaemia in particular, may have an infectious aetiology. Smith (1997 J Immunother 20: 89-100) recently suggested that the critical infectious event occurs during pregnancy, and identified the polyoma virus JC as a candidate agent. In the present study we investigated whether genomes from the JC virus, and closely related BK virus, could be detected in leukaemic cells. No positive results were obtained suggesting that JC virus is unlikely to play a direct role in leukaemogenesis. (+info)
Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC virus and BK virus. (6/481)A comparison of antibody titers to JC virus (JCV) or BK virus (BKV) was made by hemagglutination inhibition (HI) and enzyme immunoassay (EIA) with 114 human plasma samples. Antibody titers to JCV or BKV determined by HI were lower than those determined by EIA. Nevertheless, as HI titers increased so did EIA titers. When antibody data were compared by the Spearman rank correlation test, highly significant correlations were found between HI and EIA titers. Results obtained by plotting EIA antibody titers for JCV against those for BKV generally showed a reciprocal relationship, i.e., samples with high antibody titers to JCV had lower antibody titers to BKV and vice versa. Some samples, however, had antibody titers to both viruses. Of the samples tested, 25.4% (25 of 114) had HI and EIA antibody titers to JCV and BKV which were identical or closely related. This is not the scenario one would expect for cross-reactive epitopes shared by the two viruses, but one suggesting that these samples were from individuals who had experienced infections by both viruses. Adsorption with concentrated JCV or BKV antigen of sera with high antibody titers to both JCV and BKV and testing by JCV and BKV EIA gave results which support this conclusion. Although 52.6% (51 of 97) of the samples from the Japanese population tested had very high antibody titers (>/=40,960) to either JCV or BKV, none of the samples were found by a dot blot immunoassay to have antibodies which cross-reacted with simian virus 40. The results from this study, in agreement with those of others, suggest that humans infected by JCV or BKV produce antibodies to species-specific epitopes on their VP1 capsid protein, which is associated with hemagglutination and cellular binding. (+info)
Polyomaviruria in renal transplant patients is not correlated to the cold ischemia period or to rejection episodes. (7/481)Polyomaviruria was observed in one-third of all renal transplant patients, irrespective of whether their renal grafts came from a living or cadaver donor, and was not correlated to graft rejection episodes. This suggests that the renal graft ischemia period is not the major cause of polyomavirus reactivation and that reactivation of polyomavirus is not a dominant cause of graft rejection. (+info)
Documenting the epidemiologic patterns of polyomaviruses in human populations by studying their presence in urban sewage. (8/481)This is the first description, to our knowledge, of the distribution of human polyomavirus and simian virus 40 (SV40) in urban sewage. Using a nested-PCR procedure, we report the detection of human polyomaviruses JC virus (JCV) and BK virus (BKV) but not SV40 in a high percentage of urban sewage samples obtained from widely divergent geographical areas in Europe and Africa. For a total of 28 samples analyzed, JCV was detected in 26, BKV was detected in 22, and none was positive for SV40. All geographical areas showed a high prevalence of these viruses with mean estimated values of JC viral particles per ml on the order of 10(3) in Barcelona (Spain) and Nancy (France) and 10(2) in Pretoria (South Africa) and Umea (Sweden) and mean values of BK viral particles on the order of 10(2) in Pretoria and Barcelona and 10(1) in Nancy and Umea. This compares with estimated mean values of 10(2) to 10(3) for human adenovirus that was evaluated as a control. Nucleotide sequence analysis of the amplified DNA from some of the samples is also presented and represents the sequence of the most abundant JC and BK viral strains in these samples. The nucleotide sequence of the JCV detected was also analyzed in a phylogenetic study and for genomic characterization in the regulatory region. This study has shown that human polyomaviruses are spread in high concentrations in the sewage of different geographical areas and are present in contaminated environments. The frequency and concentration of JCV detected in the environment and the absence of described animal hosts suggest that JCV may be useful as a marker for fecal pollution of anthropogenic origin. The results also support the idea previously described that the strains of JCV are closely related to the ethnic origin of the population studied. The procedure applied should also be useful in future studies of population patterns of viral excretion and as a tool in epidemiological studies for the detection of changes in the prevalence of specific viral pathogens. (+info)
Polyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective,...
TY - JOUR. T1 - Polyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective, Randomized, Multicenter Study. AU - Citterio, Franco. AU - Hirsch, H. H.. AU - Vincenti, F.. AU - Friman, S.. AU - Tuncer, M.. AU - Wiecek, A.. AU - Scheuermann, E. H.. AU - Klinger, M.. AU - Russ, G.. AU - Pescovitz, M. D.. AU - Prestele, H.. PY - 2013. Y1 - 2013. N2 - Polyomavirus BK (BKV)-associated nephropathy causes premature kidney transplant (KT) failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk factors are controversial. A total of 682 KT patients receiving basiliximab, mycophenolic acid (MPA), corticosteroids were randomized 1:1 to cyclosporine (CsA) or tacrolimus (Tac). Risk factors were analyzed in 629 (92.2%) patients having at least 2 BKV measurements until month 12 posttransplant. Univariate analysis associated CsA-MPA with lower rates of viremia than Tac-MPA at month 6 (10.6% vs. 16.3%, p = 0.048) and 12 ...
Donor and Recipient BKV-Specific IgG Antibody and Posttransplantation BKV Infection: A Prospective Single-Center Study. | www...
Background: The study evaluated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus to posttransplantation BKV infection., Methods: Two hundred forty adult de novo kidney-only recipients and 15 pediatric recipients were prospectively enrolled and followed for a minimum of 18 months. Pretransplantation BKV serostatus was available for 192 adult and 11 pediatric donor-recipient pairs. Based on BKV-specific IgG enzyme immunoassay ,=8 units, subjects were divided into four groups: D+R+, D+R-, D-R+, and D-R-. BKV DNA surveillance was performed at 1, 3, 6, 12, and 24 months. The outcomes studied were development of any BKV infection, viremia, and significant viremia (,=10,000 copies/mL plasma)., Results: Of the 192 adult subjects (D+R- [n=41], D+R+ [n=42], D-R+ [n=41], and D-R- [n=68]), 89 of 192 developed any BKV infection and 62 of 89 developed BK insignificant viremia (n=33) and significant viremia (n=29). Any BKV infection developed in 25 of 41, 22 of 42, ...
Proteins of the Nuclear Factor-1 Family Act As An Activator of the Late Promoter in Human Polyomavirus BK in vitro |...
The cis-acting elements for the early and late promoters, as well as the enhancer in the prototype strains of human polyomavirus BK (BKV) are located within a 500 bp intergenic region. We previously studied the specificity of protein binding in this region in vitro and showed that the interaction of proteins of the nuclear factor-1 (NF-1) family is crucial for early promoter activity. We have now extended our study to the BKV late promoter. We show that the late promoter activity in HeLa cell extracts is poor compared to the activity of the early promoter. Using a high template to protein ratio, multiple start sites were detected by primer extension analysis. DNase I protection experiments revealed the presence of three NF-1 binding sites in the late side, in addition to those identified previously in the 68 bp repeats and C element. Competition transcription assays using binding sites for NF-1, AP-1, Sp-1 and a complete 68 bp repeat indicated that only the 68 bp repeat and the NF-1 binding site
Results of repeat renal transplantation after graft loss from BK virus nephropathy<...
TY - JOUR. T1 - Results of repeat renal transplantation after graft loss from BK virus nephropathy. AU - Geetha, Duvuru. AU - Sozio, Stephen M.. AU - Ghanta, Mythili. AU - Josephson, Michelle. AU - Shapiro, Ron. AU - Dadhania, Darshana. AU - Hariharan, Sundaram. PY - 2011/10/15. Y1 - 2011/10/15. N2 - Background.: BK virus nephropathy (BKVN) is an important cause of renal graft loss in recent years. The aims of this study are to (1) describe the management of patients undergoing retransplantation after allograft loss in the setting of BKVN and (2) to identify risk factors for BK virus replication in the retransplant. Methods.: This retrospective study compiled data on adult patients undergoing repeat transplantation after previous loss of allograft to BKVN from six US centers. Clinical, laboratory, and histopathologic data for both the transplant that failed because of BKVN and the retransplant were abstracted and reviewed. Results.: A total of 31 patients underwent retransplantation after a ...
Serval - Risk factors for BK viremia in kidney transplant recipients
Background. In the past 20 years, BK virus has emerged as a cause of early graft dysfunction after kidney transplantation. In the setting of chronic immunosuppression (IS), the latent virus can reactivate, leading to BK viremia (10-20%) and in 1-10% of kidney transplant recipients to BK virus nephropathy (BKVN). The early detection of BK viremia by serum DNA PCR screening allows prompt but controlled reduction of IS, which, despite numerous attempts to find specific antiviral agents, remains the mainstay therapy. So far, besides potent IS, no risk factor has been consistently associated with BK viremia/BKVN. The use of a ureteral stent at the time of transplantation to protect the ureterovesical anastomosis has been described as a potential trigger. In this study, we aimed at defining the incidence and kinetics of BK viremia in our local cohort of kidney transplant recipients, and analysed potential predictors of BK viremia/BKVN, including ureteral stents. Methods. We performed a singl
Caracterización de la infección neurológica por poliomavirus BK
Human polyomavirus BK (BKPyV) is the aetiological agent of polyomavirus-associated nephropathy (PVAN) and of hemorrhagic cystitis (HC) while human polyomavirus JC (JCPyV) is associated with progressive multifocal leukoencephalopathy (PML). However, JCPyV can give rise to PVAN and HC and BKPyV has been detected in cerebrospinal fluid samples (CSF) from patients with Central Nervous System (CNS) disease, including PML. During the period 1998- 2011, 2,406 CSF samples from patients with suspected JCPyV infection were tested for the presence of BKPyV, JCPyV, and SV40 large T antigen DNA by a multiplex PCR assay in the National Centre of Microbiology. Twenty neurological patients with at least one BKPyV DNApositive CSF specimen were identified. Firstly, an internally-controlled multiplex real-time PCR was developed and showed to be suitable for the diagnosis of polyomavirus BK and JC infection, providing a sensitive, reproducible and specific quantification of the viral load of both viruses in samples ...
Impact of BKV Subtype Distribution on BKV Nephropathy, Viremia, and Renal Outcome in Patients After Renal Transplantation. -...
Factors determining the course of BK viral (BKV) infection remain uncertain. We studied the role of BKV subtype distribution in BKV-infected patients after renal transplantation.-. We performed genotyping of BKV subtypes in 180 BKV-infected renal transplant recipients with BKV nephropathy (BKVN, n=69), BKV viremia (n=94), BKV viruria alone (n=17), and in 29 healthy adults and 11 dialysis patients with spontaneous BKV replication in urine. We then tested, if the frquency of certain subtypes corresponded to the severity of the infection: BKV nephropathy, BKV high viremia (,10000 copies/mL), or BKV low viremia (,10000 copies/mL). -. Ib-2 was the most frequent BKV subtype (135/220. 61%) and subtype IV the second in frequency (50/220, 23%); Ib-1 (10%), Ia (5%), II and III (1%) were less frequent. Subtype IV-infected patients had more often BKVN and/or high viremia of ,10000 copies/mL than patients with other subtypes (31/38 versus 78/125, p=0.02). Patients with low viremia of ,10000 copies/mL were ...
Hemorrhagic Cystitis in a Liver Transplant Recipient Secondary to BK Virus | ACG Case Reports Journal - An online journal of...
This is a unique case of BK virus infection associated with HC in a LT recipient. To our knowledge, this is the first reported case of this association. The prevalence of BK viremia and viruria in LT recipients is low when compared to other solid organ transplant recipients.5 The prevalence of BK viruria in LT recipients has been reported to be 7.8% compared to 26.5% in kidney transplant recipients and 25.5% in heart transplant recipients. The prevalence of BK viremia was 0% in LT compared to 12.2% in kidney transplant recipients and 7% in heart transplant recipients.6. The risk factors that have been identified for BK virus infection in LT recipients include CKD, immunosuppression and previous episode(s) of rejection.7,8 One study found that LT recipients with a history of rejection had BK viremia more frequently (40%) than those without rejection (10.6%).8 Although immunosuppression is a risk factor for BK virus infection, none of the studies have identified any specific immunosuppressive ...
Conserved archetypal configuration of the transcriptional control region during the course of BK polyomavirus evolution |...
BK polyomavirus (BKV) is widespread among humans, asymptomatically infecting children and then persisting in renal tissue. The transcriptional control region (TCR) of the BKV genome is variable among clinical isolates. Thus, archetypal TCRs with a common basic configuration generally occur in BKV isolates from the urine of immunocompromised patients, but rearranged TCRs that possibly arise from the archetypal configuration have also been detected in clinical specimens. To examine the hypothesis that archetypal strains represent wild-type strains circulating in the human population (the archetype hypothesis), we analysed 145 complete viral genomes amplified directly from the urine of non-immunocompromised individuals worldwide. These genomes included 82, three, two and 58 sequences classified as belonging to subtypes I, II, III and IV, respectively. Rearranged TCRs with long duplications or deletions were detected from two subtype I and two subtype IV genomes, but not from the other 141 genomes (thus,
Retransplantation after kidney graft loss due to polyoma BK virus nephropathy: successful outcome without original allograft...
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Isolated heart and liver transplant recipients are at low risk for polymavirus BKV nephropathy<...
TY - JOUR. T1 - Isolated heart and liver transplant recipients are at low risk for polymavirus BKV nephropathy. AU - Puliyanda, Dechu P.. AU - Amet, Nurmamet. AU - Dhawan, Archana. AU - Hilo, Lara. AU - Radha, Raju K.. AU - Bunnapradist, Suphamai. AU - Czer, Lawrence. AU - Martin, Paul. AU - Jordan, Stanley. AU - Toyoda, Mieko. PY - 2006/5/1. Y1 - 2006/5/1. N2 - Background: BKV infection and nephropathy is a significant cause of allograft dysfunction in kidney transplantation. BKV viremia, rather than viruria, corresponds to BKV nephropathy. The prevalence of BKV viremia in non-renal solid organ transplants has not been systematically evaluated. Methods: We determined prevalence of BKV viremia in kidney, combined kidney-heart, kidney-liver, kidney-pancreas, kidney-heart-liver, and heart and liver transplant recipients using BKV-PCR. Results: Seven out of 173 (4%) kidney transplant recipients had BKV viremia, with BKV , 2 × 105 copies/mL in 6/7 and 1.9 × 103 in the remaining one patient. BKV ...
Antigen-specificity of T-cell Infiltrates in Biopsies with T-cell Mediated Rejection and BK Polyomavirus Viremia: Analysis by...
Antigen-specificity of T-cell Infiltrates in Biopsies with T-cell Mediated Rejection and BK Polyomavirus Viremia: Analysis by Next Generation ...
BK Virus Nephropathy and Kidney Transplantation | American Society of Nephrology
Figure 3. Impaired immune suppression balance. Inadequate immune suppression results in rejection, whereas excessive immune suppression results in BKV nephropathy. Both conditions present as allograft dysfunction with tubulointerstitial nephritis and progression to fibrosis. ...
John Libbey Eurotext - Virologie - BK polyomavirus: virus-cell interactions, host immune response, and viral pathogenesis
The BK polyomavirus (BKPyV) is one of the main human polyomaviruses. After primary infection, it establishes a persistent infection, and acts as an opportunistic pathogen, innocuous in immunocompetent hosts, but causing potentially serious pathology in the context of immunosuppression, in particular in kidney and hematopoietic stem cell graft recipients. Much progress has been made in recent years in the description of virus-cell interactions, but many aspects of viral physiopathology remain mysterious, principally due to the asymptomatic nature of infection in immunocompetent individuals and the lack of an animal model. The characteristics of the antiviral immune response are beginning to become more clearly understood, particularly in kidney transplant patients. Work in these areas is important in order to identify patients at high risk of developing a severe infection. Indeed, in the absence of an effective antiviral therapy few therapeutic options are available, and patient management ...
QBK - Clinical: BK Virus, Molecular Detection, Quantitative, PCR, Plasma
QBK : Polyomaviruses are small (45 nm, approximately 5,000 bp), DNA-containing viruses and include 3 closely related viruses of clinical significance: Simian virus 40 (SV-40), JC virus (JCV), and BK virus (BKV). SV-40 naturally infects rhesus monkeys but can infect humans, while BKV and JCV cause productive infection only in humans.(1,2) Acquisition of BKV begins in infancy. Serological evidence of infection by BKV is present in 37% of individuals by 5 years of age and over 80% of adolescents. BKV is an important cause of interstitial nephritis and BKV-associated nephropathy (BKVAN) in recipients of kidney transplants. Up to 5% of renal allograft recipients can be affected at about 40 weeks (range 6-150) posttransplantation.(3) Quantitative PCR analysis of BKV DNA in the plasma is the most widely used blood test for the laboratory diagnosis of BKV-associated nephropathy. Importantly, the presence of BKV DNA in blood reflects the dynamics of the disease: the conversion of plasma from negative
Detection of BK virus in urine from renal transplant subjects by mass spectrometry. - Nuffield Department of Surgical Sciences
BACKGROUND: The diagnosis and management of BK virus (BKV) reactivation following renal transplantation continues to be a significant clinical problem. Following reactivation of latent virus, impaired cellular immunity enables sustained viral replication to occur in urothelial cells, which potentially leads to the development of BKV-associated nephropathy (BKVAN). Current guidelines recommend regular surveillance for BKV reactivation through the detection of infected urothelial cells in urine (decoy cells) or viral nucleic acid in urine or blood. However, these methods have variable sensitivity and cannot routinely distinguish between different viral subtypes. We therefore asked whether mass spectrometry might be able to overcome these limitations and provide an additional non-invasive technique for the surveillance of BKV and identification of recipients at increased risk of BKVAN. RESULTS: Here we describe a mass spectrometry (MS)-based method for the detection of BKV derived proteins directly
Changes in allograft function and allograft survival ra | Open-i
Changes in allograft function and allograft survival rate after BK virus-associated nephropathy (BKVAN) diagnosis. (A) Allograft function deteriorated after BKV
ZORTRESS - Oncology Nurse Advisor
Increased risk of infections and possible malignancies (eg, lymphoma, skin); kidney graft thrombosis; nephrotoxicity; and mortality in heart transplantation. Use in heart transplantation: not recommended. Avoid sun, UV light. Severe hepatic impairment or hereditary disorders (eg, galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption): not recommended. Diabetes. Obtain everolimus, cyclosporine and tacrolimus whole blood concentrations periodically (see full labeling); and trough concentrations during dose adjustments. Monitor CBCs, renal function, urine protein, lipids, blood glucose; and for pneumonitis and serious (eg, bacterial, viral, fungal, protozoal) including opportunistic infections; polyoma virus infections (eg, BK virus-associated nephropathy, and JC virus-associated progressive multiple leukoencephalopathy). Antimicrobial prophylaxis for PCP and CMV recommended. Embryo-fetal toxicity. Pregnancy; avoid. Females of reproductive potential should use highly ...
BKV VP1 monoclonal antibody (M14), clone 7D7 - (MAB3204-M14) - Products - Abnova
Mouse monoclonal antibody raised against a full-length recombinant BKV VP1. BKV VP1 (YP_717939.1, 1 a.a. ~ 369 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (MAB3204-M14) - Products - Abnova
BK Polyomavirus (Microbiology)
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EXPERIMENTAL AND CLINICAL TRANSPLANTATION
Screening for BK Viremia/Viruria and the Impact of Management of BK Virus Nephropathy in Renal Transplant Recipients. Zakaria E. Zakaria, Amir M. Elokely, Adel A. Ghorab, Adel I. Bakr, Medhat A. Halim, Osama A. Gheith, Ayman M. Nagib, Yahya Makkeyah, Mohamed A. Balaha, Mahmoud M. Magdy, Torki Al-Otaibi. Online Publication Date : Feb 19 ...
Induction Related BK Viremia in Renal Transplant Patients - Tabular View - ClinicalTrials.gov
Our standard of care has been changed from Thymoglobulin to Simulect and now patients were enrolled in this observational trial to gather data on their outcomes related to BK viremia and rejection rates. Two groups of patients were compared.. Retrospective (historical or control) group of subjects: patients who had received a kidney transplant and were inducted with Thymoglobulin prior to study initiation.. Prospective group of subjects: patients who is scheduled to receive kidney transplant and will be inducted with Simulect (Basiliximab).. Inductions in both groups was/is Standard of Care at a time of treatment. ...
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study of the Safety, Tolerability and Population...
This trial investigated the tolerability and pharmacokinetics of CMX 001 in transplant recipients with BK virus infections. The primary outcome was tolerability
Since the cloning of the BK B1 receptor in 1994 by Menke et al., several groups have begun to determine the transduction mechanisms involved in its induction (Bachvarov et al., 1996; Yang and Polgar, 1996; Ni et al., 1998; Schanstra et al., 1998;Phagoo et al., 2001). The 5′-flanking region of the human BK B1 receptor gene bears putative NF-κB as well as activator protein-1 binding motifs, a promoter organization consistent with an activation by cytokines, such as IL-1β or TNF-α (Bachvarov et al., 1996). Using transfected cultured cells, Ni et al. (1998) have demonstrated that NF-κB is involved in the inducible expression of the human BK B1 receptor gene during inflammatory processes. In resting cells, NF-κB is held inactive in the cytosol by association with inhibitory proteins of the I-κB family (Baldwin, 1996). When the NF-κB pathway is activated by agents such as lipopolysaccharide, IL-1β, and TNF-α, a phosphorylation-dependent proteolytic degradation of I-κB is initiated, ...
MACS GMP PepTivator® BKV LT - Antigens - MACS GMP Portfolio - Cell manufacturing platform - Products - Miltenyi Biotec -...
MACS GMP PepTivator BKV LT is a peptide pool that consists mainly of 15-mer peptides with 11 amino acids overlap. It has been developed for efficient in vitro stimulation and subsequent isolation of BKV LT-specific CD4+ and CD8+ T cells. - Belgique
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BK1 file extension - How to open BK1 files
The BK1 file. We collected the information you should know about the .BK1 file on this page. If you were sent a .BK1 file in an e-mail, but you dont know what to do with it, then you can find help here.
New NCCR Robotics Spin Fund - NCCR Robotics
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Regency Kee 42 Round Breakroom Table, Grey/Black and 4 M Stack Chairs, Black (TB42RDGYPBK47BK) | Staples
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Brahma Kumaris Murli 30 July 2021 (ENGLISH) Madhuban BK Murli Today - BK Daily Gyan Murli - Brahma Kumaris Murli
BRAHMA KUMARIS MURLI July 2021 : DAILY MURLI HINDI & English Today Murli Brahma kumaris BK MURLI TODAY August 2021, MURLI September 2021
Gentaur Molecular :Brady \ PTL 24 428 BK \ 018391
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Kristiansund BK - Haugesund - 2021-09-18 16:00:00 online fogadás, eredmények tabellák
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Canterbury Court - BK Property Services
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Kristiansund BK vs United, July 2019 - Abroad Red
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Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection,...
Results Twenty-five patients developed hemorrhagic cystitis. Pre-transplant BK viruria detected by quantitative PCR was positive in 96 patients. The one-year cumulative incidence of hemorrhagic cystitis was 16% in the PCR-positive group versus 9% in the PCR-negative group (P=0.1). The use of umbilical cord blood or a haploidentical donor was the only significant predictor of the incidence of hemorrhagic cystitis on univariate analysis. There was also a trend for a higher incidence after myeloablative conditioning. Multivariate analysis showed that patients who had a positive PCR pre-transplant and received haploidentical or cord blood grafts with myeloablative conditioning had a significantly higher risk of developing hemorrhagic cystitis (58%) than all other recipients (7%, P,0.001). ...
New insights on the association between the prostate cancer and the small DNA tumour virus, BK polyomavirus - Zurich Open...
In recent years the scientific literature in the field of the prostate carcinoma (PCa) pointed out on the genetic heterogeneity and mutations occurring in this tumour, while little attention was given to the causes of PCa onset, in particular infectiuos agents. In this brief commentary, we wish to point out recent advancements done on the role of the human polyomavirus BK (BKPyV) in the development of PCa by harnessing both humoral and cellular immune responses. Altogether, these new insights suggest that BKPyV is involved in the transforming activity during the multistep process of PCa development. Although these findings do not provide evidence for a causal relationship between BKPyV and PCa development, additional investigations with novel techniques will help to make it a concrete event. ...
G Proteins (Small)
Furthermore, genes involved in the regulation of the cell cycle were the most significantly upregulated set in both JCPyV- and BKPyV-infected versus uninfected cells (see Fig.?S1 in the supplemental material). explain the distinct disease outcomes. INTRODUCTION JC and BK polyomaviruses (JCPyV and BKPyV, respectively) are members of the human family. JCPyV and BKPyV were isolated in 1971, but 11 additional human polyomaviruses have been discovered in the last decade (1,C12). JCPyV is the etiological agent of progressive multifocal leukoencephalopathy (PML), a fatal neurodegenerative disease, and BKPyV causes polyomavirus-associated nephropathy (PyVAN) and hemorrhagic cystitis (HC) (1, 13). JCPyV and BKPyV are common human pathogens, for which 50 to 60% and 80% of healthy individuals, respectively, are seropositive (14,C16). Primary infection with JCPyV and BKPyV occurs early during childhood, and it is most often asymptomatic unless there is a preexisting, immunosuppressive condition (17, 18). ...
Michael J Imperiale | MCubed
Bennett, S.M., Jiang, M., and Imperiale, M.J. (2013). Role of cell type-specific ER-associated degradation in polyomavirus trafficking. J. Virol., in press.. Broekema, N.M. and Imperiale, M.J. (2013). miRNA regulation of BK polyomavirus replication during early infection. Proc. Natl. Acad. Sci. USA 110:8200-8205.. Jiang, M., Zhao, L., Gamez, M., and Imperiale, M.J. (2012). Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection. PLoS Pathog. 8(8): e1002898. doi:10.1371/journal.ppat.1002898.. Christensen, J.B., Ewing, S.G., and Imperiale, M.J. (2012). Identification and characterization of a DNA binding domain on the adenovirus IVa2 protein. Virology 433:124-130.. Imperiale, M.J. (2012). Dual-use research after the avian influenza controversy. B. Atom. Sci. http://thebulletin.org/web-edition/op-eds/dual-use-research-after-the-av..... Bennett, S.M., Broekema, N.B., and Imperiale, M.J. (2012). BK polyomavirus: emerging pathogen. Microbes Infect. ...
Table 1 - Human Polyomaviruses in Children Undergoing Transplantation, United States, 2008-2010 - Volume 18, Number 10-October...
Immunocompromised patients are at risk for disease caused by infection by some polyomaviruses. To define the prevalence of polyomaviruses in children undergoing transplantation, we collected samples from a longitudinal cohort and tested for the 9 known human polyomaviruses. All were detected; several were present in previously unreported specimen types.
BKV VP1 monoclonal antibody (M19), clone 5E6 - (MAB3204-M19) - Products - Abnova
Mouse monoclonal antibody raised against a full-length recombinant BKV VP1. BKV VP1 (YP_717939.1, 1 a.a. ~ 369 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (MAB3204-M19) - Products - Abnova
The Loss of BKV-Specific Immunity From Pretransplantation to Posttransplantation Identifies Kidney Transplant Recipients at...
Quantification of BKV-load and BKV-specific immunity have been evaluated to monitor BKV-replication and outcomes in kidney transplant recipients (KTRs) with BKV-infection.
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Haemorrhagic cystitis | Radiology Case | Radiopaedia.org
Haemorrhagic cystitis is a diffuse inflammatory condition of the urinary bladder due to an infectious or noninfectious etiology, resulting in bleeding from the bladder mucosa. Chronic and recurrent haemorrhagic cystitis often results from antic...
Role of human polyomaviruses in lymphoproliferative disorders and bladder cancer
Es sospita que els Polyomaviruses causen càncer en humans però només el poliomavirus de cèl•lules de Merkel (MCPyV) es carcinògen humà confirmat. Fins a nou poliomavirus en 468 trastorns limfoproliferatius, 1135 càncers de bufeta i 359 leucèmies limfocítica crònica (LLC) shan explorat mitjançant tres estudis cas-control a Espanya. Lexposició viral es va mesurar mitjançant enzyme linked immunosorbent assay amb virus-like-particles i tecnologia múltiplex de serologia fluorescent basada en beads. Dels limfomes explorats, nomes el limfoma difús de cèl•lules b grans (LDCBG) va mostrar una MCPyV seroprevalença significativament 6-cops mes alta (OR=6.10; 95%CI=1.88-19.75) versus controls. Els casos de càncer de bufeta van mostrar elevades seroreactivitats envers BKPyV (OR= 1.37; 95%CI=1.04-1.80) i MCPyV (OR=1.48; 95%CI=1.16-1.88). En LLC, es van observar seroprevalences més baixes per als 9 poliomavirus mesurats (OR rang=0.21-0.70). Els patrons serològics obtinguts en LDCBG y ...
Aggressive post-transplant monitoring of more importance to successful outcome following re-transplantation for BK virus...
TY - JOUR. T1 - Aggressive post-transplant monitoring of more importance to successful outcome following re-transplantation for BK virus nephropathy than absence of pretransplant viremia. AU - Womer, Karl L.. AU - Patton, Pamela R.. AU - Kaplan, Bruce. PY - 2008/11/1. Y1 - 2008/11/1. UR - http://www.scopus.com/inward/record.url?scp=53749094145&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=53749094145&partnerID=8YFLogxK. U2 - 10.1111/j.1432-2277.2008.00721.x. DO - 10.1111/j.1432-2277.2008.00721.x. M3 - Letter. C2 - 18657089. AN - SCOPUS:53749094145. VL - 21. SP - 1103. EP - 1104. JO - Transplant International. JF - Transplant International. SN - 0934-0874. IS - 11. ER - ...
Department of Medicine Faculty Directory
Co-Director, Brain Cancer Research Program, Sidney Kimmel Cancer Center. Expertise, Disease and Conditions: Brain Tumors, Medical Oncology, Neuro-Oncology, Pain Management. Research Interests: brain cancer, cancer pain, brain cancer, cancer pain. ...
Vol 4: Bladder Cancer versus Hemorrhagic Cystitis: A Case of Mistaken Identity in a 34-Year-Old Male Undergoing Therapy for...
Vol 4: Bladder Cancer versus Hemorrhagic Cystitis: A Case of Mistaken Identity in a 34-Year-Old Male Undergoing Therapy for Granulomatosis with Polyangiitis.. This article is from Case Reports in Nephrology and Urology, volume 4.AbstractA 34-year-old male was referred for manage. Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
antibodies vs immunity
Quantitative real-time polymerase chain response detection of BK virus utilizing labeled primers. BACKGROUND BK virus infections amongst immunocompromised sufferers are related to illness of the kidney or urinary bladder. Excessive viral hundreds, decided by quantitative polymerase chain response (PCR), have been correlated with medical illness. OBJECTIVE To develop and consider a novel technique for real-time PCR detection and quantification of BK virus utilizing…. ...
Quantitative real-time polymerase chain response detection of BK virus utilizing labeled primers. BACKGROUND BK virus infections amongst immunocompromised sufferers are related to illness of the kidney or urinary bladder. Excessive viral hundreds, decided by quantitative polymerase chain response (PCR), have been correlated with medical illness. OBJECTIVE To develop and consider a novel technique for real-time PCR detection and quantification of BK virus utilizing…. ...
The kinetics of urinary shedding of BK virus in children with renal disease<...
TY - JOUR. T1 - The kinetics of urinary shedding of BK virus in children with renal disease. AU - Yamamoto, Yasuto. AU - Morooka, Masashi. AU - Ihira, Masaru. AU - Yoshikawa, Tetsushi. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Children with renal diseases are typically treated with immunosuppressive drugs, which place them at high risk of reactivation of the BK virus (BKV). Currently, little is known about the impact of immunosuppressive drugs on the kinetics of urinary shedding of BKV and viral reactivation in pediatric patients with renal diseases. Urine samples were collected monthly for 1 year from 20 children (median age, 9 years; range, 4-15 years) with renal diseases and subjected to real-time PCR. Urinary shedding of BKV was detected in 35% (7/20) of the patients, three of these patients having persistent viral DNA excretion (two cases, twelve times, one case, four times) and four having intermittent viral DNA excretion. Thirty-four of the 240 urine samples contained BKV DNA (median copy ...
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News & Events · NCCR Kidney.ch
See the latest news from the NCCR Kidney.CH below.. The NCCR also regularly organizes educational, networking and outreaching events. Information on upcoming and past events of the NCCR Kidney.CH and other organizers can be found below. Please use the drop-down menu to confine your search.. ...
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Use this form to contact us and we will get back to you as soon as possible. Alternatively you can email us on [email protected] (general enquiries); [email protected] (press enquiries) or [email protected] (tech transfer enquiries ...
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The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K. The BK virus is similar to ... The BK virus is a member of the polyomavirus family. Past infection with the BK virus is widespread, but significant ... Overview of the BK virus MicrobiologyBytes: Polyomaviruses Reploeg MD, Storch GA, Clifford DB (July 2001). "Bk virus: a ... BK virus is an abbreviation of the name of the first patient, from whom the virus was isolated in 1971 (the patient was then 29 ...
Human immunodeficiency virus, parvovirus B19 and BK virus are known to induce these antibodies. There is little evidence ... Reploeg MD, Storch GA, Clifford DB (July 2001). "Bk virus: a clinical review". Clin. Infect. Dis. 33 (2): 191-202. doi:10.1086/ ... Epstein-Barr virus is also known to induce dsDNA antibodies, as seen after immunisation of animals with EBNA-1 epitopes. Anti- ... These motifs can be key features within the pathogenesis of particular diseases, for example Human Papilloma Virus. Kavanaugh A ...
JC virus & BK virus only cause disease in immunocompromised patients Was once thought to be due to a slow virus but is now ... A slow virus is a virus, or a viruslike agent, etiologically associated with a slow virus disease. A slow virus disease is a ... as in the cases of JC virus and BK virus), or, in the case of prions, the identity of the agent involved. Slow viruses cause a ... Pinto M, Dobson S (January 2014). "BK and JC virus: a review". The Journal of Infection. 68 (Suppl 1): S2-S8. doi:10.1016/j. ...
... most notably BK virus, JC virus, and SV40. It is essential for proliferation in the viruses that express it and is thought to ... Most of these viruses are very common and typically asymptomatic in most human populations studied. BK virus is associated with ... Kuppachi S, Kaur D, Holanda DG, Thomas CP (April 2016). "BK polyoma virus infection and renal disease in non-renal solid organ ... Kelley WL, Georgopoulos C (April 1997). "The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can ...
Progressive multifocal leukoencephalopathy
In December 2021, Cellevolve announced it is launching a clinical trial for the treatment of PML utilizing BK virus specific T- ... 2018-10-11). "Allogeneic BK Virus-Specific T Cells for Progressive Multifocal Leukoencephalopathy". New England Journal of ... It is caused by the JC virus, which is normally present and kept under control by the immune system. The JC virus is harmless ... The virus causes disease only when the immune system has been severely weakened. PML is most common in people ...
Epstein-Barr virus infection
Virus latency Herpesviridae BK virus Low-dose naltrexone "IMMUNODEFICIENCY 32B; IMD32B". OMIM. OMIM.org. Retrieved 19 March ... Transmission of this virus through the air or blood does not normally occur. The incubation period, or the time from infection ... Periodically, the virus can reactivate and is commonly found in the saliva of infected persons. Reactivated and post-latent ... A late event in a very few carriers of this virus is the emergence of Burkitt's lymphoma and nasopharyngeal carcinoma, two rare ...
Purighalla, R; Shapiro, R; McCauley, J; Randhawa, P (1995). "BK virus infection in a kidney allograft diagnosed by needle ... Van Aalderen, MC; Heutinck, KM; Huisman, C; Ten Berge, IJ (2012). "BK virus infection in transplant recipients: Clinical ... Moriyama, Takahito; Sorokin, Andrey (2008). "Repression of BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells ... Several viruses mediated the emergence of decoy cells, amongst which cytomegalovirus and polyomavirus. Decoy cells are virus ...
Choroid plexus papilloma
Simian virus (SV) 40 has been linked in studies to the development of choroid plexus tumors (CPTs). The BK and JC viruses have ... Okamoto H, Mineta T, Ueda S, Nakahara Y, Shiraishi T, Tamiya T, Tabuchi K. Detection of JC virus DNA sequences in brain tumors ... Expression of the simian virus 40 large tumor antigen (Tag) and formation of Tag-p53 and Tag-pRb complexes in human brain ...
... shows anti-BK virus activity in a subgroup of transplant recipients. Cidofovir is being investigated as a ... "Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy". Pediatric Transplantation. ... It has inhibitory effects on varicella-zoster virus replication in vitro although no clinical trials have been done to date, ... Magee WC, Hostetler KY, Evans DH (August 2005). "Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir ...
BK virus is now being increasingly recognised as a transplant risk factor which may lead to kidney disease or transplant ... Updated: 5 December 2008 Chong S, Antoni M, Macdonald A, Reeves M, Harber M, Magee CN (July 2019). "BK virus: Current ...
Eugene O. Major
Throughout his career, Major has conducted research on viruses including BK virus, adenoviruses, JC virus, simian virus 40 ( ... Olive, DM; Lampert, M; Major, EO (1980). "Comparison of wild-type BK virus DNA and BK virion DNA rescued from virus-transformed ... Major, E. O.; Di Mayorca, G. (1973). "Malignant Transformation of BHK21 Clone 13 Cells by BK Virus-A Human Papovavirus". ... where he researched papovaviruses such as BK virus with Giampiero Di Mayorca. (The papovaviruses have since been split into two ...
Urine-diverting dry toilet
BK virus or Simian virus. The Ebola virus may also be found in urine from an infected person. The exact survival time of this ... Vanchiere, John A. (12 January 2005). "Detection of BK virus and simian virus 40 in the urine of healthy children". Journal of ... "Ebola (Ebola Virus Disease)Transmission, Q&As on Transmission". CDC (Centres for Disease Control and Prevention). 20 November ... particular virus in human urine outside of the human body is unclear but probably "up to several days" like with other body ...
Products of conception
Another virus, BK polyomavirus has been detected in the same tissues, but with lesser extent. According to the 2006 WHO ... Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in ... Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in ...
It furthermore enables detection for CMV-, EBV-, influenza-, and BK virus specific CD8+ T cells. Dextramer CMV kit - These MHC ... Virus Dextramer collection 1 - provides reagents for detection, quantification and isolation of virus specific T cells. ...
Another virus, BK polyomavirus has been detected in the same tissues, but with lesser extent. In reptiles, birds, and ... Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in ... Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in ...
Teriflunomide also has antiviral effects against numerous viruses including CMV, HSV1 and the BK virus, which it achieves by ... Polyoma BK virus nephropathy Kimura's disease Systemic lupus erythematosus Felty's syndrome Takayasu arteritis Granulomatosis ... Blanckaert K, De Vriese AS (December 2006). "Current recommendations for diagnosis and management of polyoma BK virus ...
... including two human viruses - BK virus and JC virus - and the simian virus SV40; the BK, JC, and SV40 examples are by far the ... BK virus and JC virus, as well as the simian polyomavirus SV40. Agnoprotein is typically quite short: examples from BK virus, ... Among sequenced BK virus genomes, agnoprotein is the most variable viral protein in amino acid sequence. Differences in tissue ... Its functions are poorly characterized even in well-studied viruses. Null mutant viruses without agnoprotein are generally ...
Chicken anemia virus
Quinn, PJ; Markey, BK; Leonard, FC; Fitzpatrick, ES; Fanning, S (2015). "Chicken anaemia virus infection". Concise Review of ... Chicken anemia virus, or CAV, is currently a member of the Anelloviridae family which is found worldwide. The virus only ... The virus is very resistant in the environment, making elimination very difficult. The disease and virus have many names ... chicken infectious anemia virus, and chicken anemia agent. When this virus was first discovered in 1979, it ...
Cafeteria roenbergensis virus
PMID 28710447.> Colson, P; De Lamballerie, X; Yutin, N; Asgari, S; Bigot, Y; Bideshi, BK; Cheng, XW; Federici, BA; Van Etten, ... Phylogenetic analysis indicates that the virus is a nucleocytoplasmic large DNA virus (NCLD virus). Acanthamoeba polyphaga ... Resolution of the virus structure by cryo-electron microscopy yielded an icosahedral virus capsid with a T number of 499 and a ... "A virus so large it gets viruses". Ars Technica. Retrieved 2010-03-05. Fischer, M. G.; Suttle, C. A. (2011). "A Virophage at ...
Cauliflower mosaic virus
Blevins, T.; Rajeswaran, R.; Aregger, M.; Borah, BK.; Schepetilnikov, M.; Baerlocher, L.; Farinelli, L.; Meins, F.; et al. (Jul ... 1999). "Virus taxonomy--1999. The universal system of virus taxonomy, updated to include the new proposals ratified by the ... Adv Virus Res. Advances in Virus Research. Vol. 44. pp. 1-67. doi:10.1016/s0065-3527(08)60327-9. ISBN 9780120398447. PMID ... The complete molecular characterization and study of this virus was not carried further. Cauliflower mosaic virus possesses a ...
Virus (Hypocrisy album)
Virus at AllMusic. Retrieved 26 March 2021. "Hypocrisy - Virus". BW&BK. 12 October 2005. "Austriancharts.at - Hypocrisy - Virus ... Virus is the tenth studio album by Swedish melodic death metal band Hypocrisy. It was released on 19 September 2005 by Nuclear ... "Swedishcharts.com - Hypocrisy - Virus". Hung Medien. Retrieved 26 March 2021. Official website (Use dmy dates from September ... "Offiziellecharts.de - Hypocrisy - Virus" (in German). GfK Entertainment Charts. Retrieved 26 March 2021. " ...
BK virus, poxviruses, and herpes simplex viruses. Brincidofovir appears to have potential for the treatment of Ebola virus ... as ebolaviruses are RNA viruses and thus do not contain DNA as the above-mentioned viruses. "FDA approves drug to treat ... the effectiveness of brincidofovir was studied in animals infected with viruses that are closely related to the variola virus. ... Portals: Medicine Viruses (Source attribution, Articles with short description, Short description is different from Wikidata, ...
Western African Ebola virus epidemic
BK; Strong, JE; Grolla, A; Wolz, A; Kargbo, B; Kargbo, DK; Formenty, P; Sanders, DA; Kobinger, GP (19 February 2015). " ... Ebola virus disease is caused by four of six viruses classified in the genus Ebolavirus. Of the four disease-causing viruses, ... Ebola virus (formerly and often still called the Zaire Ebola virus) is dangerous and is the virus responsible for the epidemic ... These people may be the people who can spread the virus better, but we still don't know that yet. A virus can change itself to ...
Immunosuppression BK virus Behcet's Disease Discovery and development of mTOR inhibitors Treatment methods for preventing organ ...
Infections associated with diseases
"BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors". Polyomaviruses and Human ... The virus causing this illness was isolated in 1937. The rash typical of Lyme borreliosis was identified the early 1900s. ... Natelson, BH; Ye, N; Moul, DE; Jenkins, FJ; Oren, DA; Tapp, WN; Cheng, YC (1994). "High titers of anti-Epstein-Barr virus DNA ... Atkinson, RL (2007). "Viruses as an etiology of obesity". Mayo Clinic Proceedings. 82 (10): 1192-8. doi:10.4065/82.10.1192. ...
Hepatitis C virus
Biswal BK, Wang M, Cherney MM, et al. (August 2006). "Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase ... The hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ... Several additional viruses in the genus have been described in bats and rodents. The hepatitis C virus particle consists of a ... Hepatitis C virus is predominantly a blood-borne virus, with very low risk of sexual or vertical transmission. Because of this ...
Hepatitis delta virus ribozyme
Lee TS, Radak BK, Harris ME, York DM (2016). "A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme ... The hepatitis delta virus (HDV) ribozyme is a non-coding RNA found in the hepatitis delta virus that is necessary for viral ... In addition to the sense (genomic version), all HDV viruses also have an antigenomic version of the HDV ribozyme. This version ... Page for Hepatitis delta virus ribozyme at Rfam Subviral RNA database entry for HDV ribozyme (Articles to be expanded from May ...
BK virus and JC virus, among others. Founded in 1983, IBT was the first laboratory to offer a test to definitively diagnose ...
Murray Valley encephalitis virus
Marshall ID, Brown BK, Keith K, Gard GP, Thibos E (1982). "Variation in arbovirus infection rates in species of birds sampled ... Murray Valley encephalitis virus (MVEV) is a zoonotic flavivirus endemic to northern Australia and Papua New Guinea. It is the ... The virus was isolated from human samples in 1951 during an epidemic in the Murray Valley, Australia. Epidemics usually occur ... "Murray Valley encephalitis virus infection-Fact Sheet". Department of Health and Ageing. Archived from the original on 18 ...
Sumibcay L, Kadjo B, Gu SH, Kang HJ, Lim BK, Cook JA, et al. (January 2012). "Divergent lineage of a novel hantavirus in the ... Nova virus is a single-stranded, negative-sense, enveloped RNA virus with a trisegmented genome. It is one of the most ... In 2009, Nova virus was first isolated from the archival liver tissue of the European mole (Talpa europaea) captured in Hungary ... Neither one of them, including the Nova virus, has yet been connected to a disease in humans. Considering the fact that the ...
... thin viruses that infect bacteria) by fusing the virus's capsid protein to one peptide out of a collection of peptide sequences ... Kehoe JW, Kay BK (November 2005). "Filamentous phage display in the new millennium". Chem. Rev. 105 (11): 4056-72. doi:10.1021/ ... viruses that infect bacteria) to connect proteins with the genetic information that encodes them. In this technique, a gene ... "In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden ...
When CIN3 lesions lead to cancer, most of them have the assistance of the HPV virus, but that is not always the case, which is ... Singh GK, Miller BA, Hankey BF, Edwards BK (September 2004). "Persistent area socioeconomic disparities in U.S. incidence of ... HPV vaccines protect against two to seven high-risk strains of this family of viruses and may prevent up to 90% of cervical ... 1958). During the 1960s and 1970s it was suspected that infection with herpes simplex virus was the cause of the disease. In ...
Bovine stool associated circular virus
Kim HK, Park SJ, Nguyen VG, Song DS, Moon HJ, Kang BK, Park BK (2011) Identification of a novel single stranded circular DNA ... This virus appears to form a clade with the chimpanzee stool associated circular virus. Their relationship with other viruses ... Single-stranded DNA viruses, Unaccepted virus taxa, All stub articles, Virus stubs). ... Bovine stool associated circular virus is a single stranded DNA virus with a circular genome that was isolated from bovine ...
Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997). "The receptor binding site of human interleukin-3 defined ... Than S, Oyaizu N, Pahwa RN, Kalyanaraman VS, Pahwa S (1994). "Effect of human immunodeficiency virus type-1 envelope ... Feng Y, Klein BK, McWherter CA (1996). "Three-dimensional solution structure and backbone dynamics of a variant of human ...
It is believed to be caused by mismatch between the rootstock and scion rather than an infection by a fungus or a virus. In ... doi:10.1021/bk-2002-0802.ch018. ISBN 978-0-8412-3729-2. Oz Clark&Margaret Rand (2001). Oz Clarke's Encyclopedia of Grapes. ...
Myron S. Cohen
J Infect Dis 180 (6):2039-43, Chakraborty H, Sen PK, Helms RW, Vernazza PL, Fiscus SA, Eron JJ, Patterson BK, Coombs RW, ... Strategic use' of HIV medicines could help end transmission of virus". Archived from the original on 23 July 2012. Retrieved 16 ... Cohen began studying the effect of this and later drugs on the amount of virus in genital secretions. This led to the idea that ...
Bruunsgaard H, Pedersen AN, Schroll M, Skinhøj P, Pedersen BK (December 2001). "Decreased natural killer cell activity is ... can be envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses ...
Robyn S. Klein
Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, ... Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection. Cain ... Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. Klein RS, Lin E, Zhang B, Luster ... For example, since West Nile Virus has been shown to cause significant brain damage leading to memory loss, Klein's lab ...
Patel BK, Liebman SW (2007). ""Prion-proof" for [PIN+]: infection with in vitro-made amyloid aggregates of Rnq1p-(132-405) ... The original paper that proposed Mca1 is a prion was retracted ] Fungi portal Viruses portal Prion Sup35p Epigenetics Amyloid ...
Infection by RNA viruses can trigger the RNAi cascade. It is likely dicer is involved in viral immunity as viruses that infect ... Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J (May 2012). "DICER1 loss and ... Similarly to humans, insect viruses have evolved mechanisms to avoid the RNAi pathway. As an example, Drosophila C virus ... In humans, the viruses HIV-1, influenza, and vaccinia encode such RNAi suppressing proteins. Inhibition of dicer is beneficial ...
History of medicine
... the Influenza A virus subtype H5N1 from 2004, the Ebola virus epidemic in West Africa and onwards. Mary Putnam Jacobi (1842- ... p. Bk XI:804-48. Risse GB (1990). Mending bodies, saving souls: a history of hospitals. Oxford University Press. p. 56. ISBN ... several strains of influenza and human papilloma virus. The long-known vaccine against Smallpox finally eradicated the disease ...
History of computing in the Soviet Union
About 60,000 were BK-0010s, as part of the KUVT-86 computer-facility systems. Although Soviet hardware copies lagged somewhat ... August 1988 - The Soviet Union's first computer virus, known as DOS-62, is detected in the Institute of Program Systems of the ... The Vector could display up to 256 colors when the BK-0010 had only four hard-coded colors, without palettes. In 1987, it was ... That year, the Elektronika BK-0010 was the first Soviet personal computer in common use in schools and as a consumer product. ...
"Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus ... Zolotukhin AS, Felber BK (Jan 1999). "Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency ... "A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus ... virus type 1 Rev". Journal of Virology. 73 (1): 120-7. doi:10.1128/JVI.73.1.120-127.1999. PMC 103815. PMID 9847314. Schmitt C, ...
This is most commonly caused by respiratory syncytial virus (RSV, also known as human pneumovirus). Other agents that cause ... 1.74 MB) from the Scottish Intercollegiate Guidelines Network Ralston, SL; Lieberthal, AS; Meissner, HC; Alverson, BK; Baley, ... Acute bronchiolitis is usually the result of infection by respiratory syncytial virus (72% of cases) or human rhinovirus (26% ... Carbonell-Estrany X, Figueras-Aloy J (2004). "Identifying risk factors for severe respiratory syncytial virus among infants ...
Sederdahl BK, Williams JV (13 January 2020). "Epidemiology and Clinical Characteristics of Influenza C Virus". Viruses. 12 (1 ... that contain weakened viruses. There are three types of inactivated vaccines: whole virus, split virus, in which the virus is ... Influenza B virus (IBV) and Influenza C virus (ICV) primarily infect humans, and Influenza D virus (IDV) is found in cattle and ... Notable HPAI viruses include HPAI H5N1 and HPAI H7N9. HPAI viruses have been a major disease burden in the 21st century, ...
Cole BK, Lieb DC, Dobrian AD, Nadler JL (Jul 2013). "12- and 15-lipoxygenases in adipose tissue inflammation". Prostaglandins ... "The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new ...
BK virus Epstein-Barr virus infection Glomerulosclerosis--WebMD (Articles with short description, Short description is ...
Genetically modified maize
Tan S, Evans RR, Dahmer ML, Singh BK, Shaner DL (March 2005). "Imidazolinone-tolerant crops: history, current status and future ... In 2007, South African researchers announced the production of transgenic maize resistant to maize streak virus (MSV), although ... Marra MC, Piggott NE, Goodwin BK (2012). "The impact of corn rootworm protected biotechnology traits in the United States". ... November 2007). "Maize streak virus-resistant transgenic maize: a first for Africa". Plant Biotechnology Journal. 5 (6): 759-67 ...
Waters LS, Minesinger BK, Wiltrout ME, D'Souza S, Woodruff RV, Walker GC (March 2009). "Eukaryotic translesion polymerases and ... Roulston A, Marcellus RC, Branton PE (1999). "Viruses and apoptosis". Annual Review of Microbiology. 53: 577-628. doi:10.1146/ ... viruses which infect bacteria); however, more complex organisms with more complex genomes have correspondingly more complex ... especially aromatic compounds that act as DNA intercalating agents viruses The replication of damaged DNA before cell division ...
Vesicular stomatitis virus is believed to be taken up by the autophagosome from the cytosol and translocated to the endosomes ... Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J ( ... A subset of viruses and bacteria subvert the autophagic pathway to promote their own replication. Galectin-8 has recently been ... "Subversion of cellular autophagosomal machinery by RNA viruses". PLOS Biology. 3 (5): e156. doi:10.1371/journal.pbio.0030156. ...
List of skin conditions
B-K mole, Clark's nevus, dysplastic melanocytic nevus, nevus with architectural disorder) Dysplastic nevus syndrome (B-K mole ... Viscerotropic leishmaniasis Wheat warehouse itch Virus-related cutaneous conditions are caused by two main groups of viruses- ... Alphavirus infection Asymmetric periflexural exanthem of childhood (unilateral laterothoracic exanthem) B virus infection ... viruses, or parasites. Bacterium-related cutaneous conditions often have distinct morphologic characteristics that may be an ...
Huang ZM, Tan T, Yoshida H, Mori K, Ma Y, Yen TS (September 2005). "Activation of hepatitis B virus S promoter by a cell type- ... Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, et al. (April 2012). "The molecular basis for selective inhibition ...
Many bacteria and viruses elicit a TH1-mediated immune response, which down-regulates TH2 responses. The first proposed ... Panda R, Ariyarathna H, Amnuaycheewa P, Tetteh A, Pramod SN, Taylor SL, Ballmer-Weber BK, Goodman RE (February 2013). " ... "Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological ...
BK, Binukumar; Bal, Amanjit; Kandimalla, Ramesh JL; Gill, Kiran Dip (2010-11-13). "Nigrostriatal neuronal death following ... "Zika Virus". 2014-11-05. Retrieved 2016-09-07. "Naled for Mosquito Control". Environmental Protection Agency. 2016-07-05. " ... Control and Prevention and United States Environmental Protection Agency for the prevention of the spread of the Zika virus in ...
Mosquito bite allergy
Cases associated with chronic active Epstein-Barr virus infection commonly progress to a more serious Epstein-Barr virus- ... Singh S, Mann BK (2013). "Insect bite reactions". Indian Journal of Dermatology, Venereology and Leprology. 79 (2): 151-64 ... Individuals with certain Epstein-Barr virus-associated lymphoproliferative, non-Epstein-Barr virus malignant lymphoid, or other ... Upon reactivation, the virus expresses certain of its gene products, particularly that of its LMP-1 oncogene, as well as ...
Velayati A, DePaolo J, Gupta N, Choi JH, Moaven N, Westbroek W, Goker-Alpan O, Goldin E, Stubblefield BK, Kolodny E, Tayebi N, ... SCARB2 is a receptor for two viruses that cause hand, foot, and mouth disease in children, Enterovirus 71 and Coxsackievirus ... "Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity". Journal of Virology. 81 (7): 3162-9. ...
Brandt C, Pedersen BK (2010). "The role of exercise-induced myokines in muscle homeostasis and the defense against chronic ... this highly contagious virus normally causes a milder illness called Hand, foot, and mouth disease but can cause life- ... Pedersen BK (July 2013). "Muscle as a secretory organ". Comprehensive Physiology. Vol. 3. pp. 1337-62. doi:10.1002/cphy.c120033 ... Petersen AM, Pedersen BK (April 2005). "The anti-inflammatory effect of exercise". Journal of Applied Physiology. 98 (4): 1154- ...
"Tilapia lake virus, Peru". www.oie.int. Retrieved 2019-03-12. Behera BK, Pradhan PK, Swaminathan TR, Sood N, Paria P, Das A, ... Foster JE, Mendoza JA, Seetahal J (2018). "Chapter 7 - Viruses as Pathogens: Animal Viruses, With Emphasis on Human Viruses". ... Tilapia lake virus is a negative-sense, single-stranded RNA virus. It belongs to Group V of the Baltimore Classification System ... "Tilapia lake virus (TiLV)-a novel orthomyxo-like virus" (PDF). World Organisation for Animal Health (OIE). February 2018. ...
2008-09 Manchester United F.C. season
Wayne Rooney, who had been expected to play, was not in the squad, having been sidelined by a virus and Dimitar Berbatov was ... Wayne Rooney declared himself fit after having picked up a knock against Aalborg BK in midweek, and was the orchestrator of ... Dimitar Berbatov was unable to fully recover from his virus, but was named on the bench for United, while Wayne Rooney was ... United got their first win of the Champions League season on 30 September 2008, when they visited Aalborg BK. The Red Devils ...
Search of: bk-virus nephropathy* - Results on Map - ClinicalTrials.gov
Hints: Click on a [map] link to show a map of that region. Click on a [studies] link to search within your current results for studies in that region. Use the back button to return to this list and try another region. Studies with no locations are not included in the counts or on the map. Studies with multiple locations are included in each region containing locations ...
Browsing by Subject "BK Virus"
BK Virus-Specific T Cells May Be an Effective Option to Treat Progressive Multifocal Leukoencephalopathy
BK virus-specific T-cell infusions have been shown to clear JC virus in the cerebrospinal fluid (CSF) and relieve clinical ... each patients CSF was examined before each infusion of BK virus-specific T-cell infusion to measure JC viral load. BK virus- ... In this study, BK virus-specific T cells have shown to be effective in treating these patients and decreasing JC virus loads. ... The JC virus comes from the Polyomaviridae family, a virus family with similar antigens and genetic immunogenicity as the BK ...
Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation. | StemBook
Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients | American...
Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients. Donald ... Because the intervention unexpectedly increased rates of BK virus infections, our findings underscore the complexities of ... Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients ... Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients ...
Roche receives FDA clearance for BK virus quantitative test on cobas 6800/8800 Systems to support better care for transplant...
Roche receives FDA clearance for BK virus quantitative test on cobas 6800/8800 Systems to support better care for transplant ... Epstein-Barr virus and BK virus so they can simultaneously monitor and improve care for transplant patients who are at risk for ... enabling simultaneous testing of BK virus with Cytomegalovirus and Epstein-Barr virus ... Immunocompromised transplant patients are at risk of major complications when infected with BK virus ...
... Role of infectious agents in the carcinogenesis of brain and head and neck cancers. October 10, 2013. 34 ... Tagged: bk epstein-barr-virus, brain cancer, carcinogenesis, central-nervous-system, cytomegalovirus, cytomegalovirus-infection ... epstein-barr-virus, head and neck cancer, hiv, human papilloma virus, human polyomavirus, kaposis-sarcoma lung-cancer, ... In the case of brain cancer, no infection has been accepted as directly oncogenic, although a number of viruses and parasites ...
BK Virus DNA Detection and Quantification, Random, Urine (UBKQN)
BK viral load, BK virus by PCR, BK virus DNA quant, BKV by PCR, BKV DNA quant, BKV viral load ... BK viral load, BK virus by PCR, BK virus DNA quant, BKV by PCR, BKV DNA quant, BKV viral load ... ON AVERAGE, QUANTITATIVE BK VIRUS (BKV) DNA RESULTS IN URINE TESTED WITH THIS ASSAY CAN BE UP TO 3.5-FOLD (ABOUT 0.54 LOG IU/ML ... ON AVERAGE, QUANTITATIVE BK VIRUS (BKV) DNA RESULTS IN URINE TESTED WITH THIS ASSAY CAN BE UP TO 3.5-FOLD (ABOUT 0.54 LOG IU/ML ...
Book Bk (Polyomavirus Virus (Quantitative) Online in Best Price | Healthwire
B Tests - HSE.ie
American Journal of Case Reports | Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients...
Crown Virus - BK-PBK.Info - for BKs & PBKs or BKWSU & AIVV Supporters, Children, Students & Disciples
When the virus is released in the atmosphere by a symptomatic, or even an asymptomatic, infected individual, the heavier virus ... may inhale the virus and get infected.. When the sun is shining brightly, the virus in the atmosphere will be eliminated ... novel corona virus, or novel Crown Virus, best describes its preordained function and purpose!. It has also to be ... and breathe in the virus and get infected - assuming that the virus may persist in the atmosphere even for only a few minutes, ...
Urinary Exosomes: A Promising Biomarker for Disease Diagnosis
Details for: Malaria and some Polyomaviruses (SV40, BK, JC, and Merkel cell viruses) › WHO HQ Library catalog
Simian virus , BK virus , JC virus , Merkell cell Polyomavirus ... DC.IARC SERIALS Malaria and some Polyomaviruses (SV40, BK, JC, ... Malaria and some Polyomaviruses (SV40, BK, JC, and Merkel cell viruses) Contributor(s): International Agency for Research on ... Details for: Malaria and some Polyomaviruses (SV40, BK, JC, and Merkel cell viruses) ... and Merkel cell viruses) DC.IARC SERIALS Diesel and gasoline engine exhausts and some nitroarenes DC.IARC SERIALS ...
Browsing by Subject
Role of BK polyomavirus (BKV) and Torque teno virus (TTV) in liver transplant recipients with renal impairment | Microbiology...
BK viraemia was detected in 8.7 % of patients with BK viruria up to 4 years after LT. BKV-specific antibodies were detected in ... There was no correlation between renal impairment and the detection of BK DNA in urine (OR 0.983). TTV DNA was detected in 84.6 ... BK viruria was detected up to 21 years after transplantation in 16.9 % of cases. ... Torque teno virus (TTV) is a surrogate marker for immunosuppression that does not have a clear association with any human ...
Induction of malignant subcutaneous sarcomas in hamsters by a recombinant DNA containing BK virus early region and the...
Induction of malignant subcutaneous sarcomas in hamsters by a recombinant DNA containing BK virus early region and the ... containing BK virus (BKV) early region gene and the activated human c-Harvey-ras(c-Ha-ras) oncogene derived from T24 bladder ... containing BK virus (BKV) early region gene and the activated human c-Harvey-ras(c-Ha-ras) oncogene derived from T24 bladder ...
DailyMed - MYCOPHENOLIC ACID tablet, delayed release
BK virus. BK virus can affect how your kidney works and cause your transplanted kidney to fail. ▪. Hepatitis B and C viruses. ... Hepatitis viruses can affect how your liver works. Talk to your doctor about how hepatitis viruses may affect you.. •. A brain ... PVAN, especially due to BK virus infection, is associated with serious outcomes, including deteriorating renal function and ... Polyomavirus associated nephropathy (PVAN), especially due to BK virus infection, associated with serious outcomes, including ...
40 questions with answers in RENAL DISEASE | Science topic
What antiviral agents could be used for the treatment of JC & BK polyoma virus induced nephropathy in renal transplant patients ... ITP also occurs wit influenza virus vaccine which do not use vector ... at a speed intended to keep ahead of the mutability of the virus reducing and the possibility of more virulent and ...
Hematopoietic Stem Cell Transplantation (HSCT): Practice Essentials, Historical Background, Indications for HSCT
Later onset is associated with infections such as adenovirus or BK virus.  Therapy is largely supportive, with ... and herpes zoster virus. CMV, Epstein-Barr virus (EBV), and hepatitis viruses are particularly important. ... Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant. ... hepatitis B and C viruses (including HCV nucleic acid amplification testing [NAT]), human T-cell lymphotropic virus-1/2 (HTLV-I ...
Marburg Virus Disease Outbreaks | Marburg (Marburg Virus Disease) | CDC
Learn more on current and past outbreaks of Marburg virus disease. ... Johnson ED, Johnson BK, Silverstein D, et al. Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya ... Smith DH, Johnson BK, Isaacson M, et al. Marburg-virus disease in Kenya. Lancet. 1982; 1(8276):816-820. ... History of Marburg Virus Disease Outbreaks. Year(s). Country. Apparent or suspected origin. Reported number of human cases. ...
Infectious Diseases Now - Présentation - EM consulte
Origine de la réactivation virale chez les patients transplantés rénaux avec une néphropathie à BK virus ... High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with ... Screening around a COVID-19 cluster: Exploring its impact on a local virus outbreak ...
Crowley Brendan | St James's Hospital
SCOP 1.61: Structural Classification of Proteins - extended
Gengraf Oral Solution (Cyclosporine Oral Solution): Uses, Dosage, Side Effects, Interactions, Warning
... and polyoma virus-associated nephropathy (PVAN), especially BK virus resulting in graft loss have been reported. (See WARNINGS ... and polyoma virus-associated nephropathy (PVAN), especially due to BK virus infection, which have been observed in patients ... including polyoma virus infections. Polyoma virus infections in transplant patients may have serious, and sometimes, fatal ... Polyoma Virus Infections. Patients receiving immunosuppressants, including Gengraf® , are at increased risk for opportunistic ...
VPM oversees clinical trial and translational project management - Positive Phase I data of client Memo Therapeutics AG
MTxs lead program, AntiBKV, is a highly effective and safe neutralizing antibody to treat BK virus infection in kidney ... The project included a Phase I clinical trial with AntiBKV, an antibody targeting BK polyomavirus (BKV) infection in renal ... BKV is a wide-spread virus persisting in approximately 80-90 % of the population. While clinically not relevant in healthy ... individuals, the virus is often reactivated in immunosuppressed patients. Reactivation has been shown to be a frequent cause of ...
Acute Kidney Injury in the Modern Era of Allogeneic Hematopoietic Stem Cell Transplantation | American Society of Nephrology
Symptomatic BK virus infection is associated with kidney function decline and poor overall survival in allogeneic hematopoietic ... Regarding viral infections, we did not find any association with CMV serostatus, and BK virus nephropathy was suspected in only ... Other etiologies (n=3) include tumor lysis syndrome (n=2) and suspected BK virus nephropathy (n=1). ... and suspected BK virus nephropathy (one of 64; 2%) (Figure 3). Among the 21 patients requiring KRT, etiologies of AKI included ...
Pleurodynia Workup: Approach Considerations, Laboratory Studies, Imaging Studies
... and BK virus nephropathy. Clin Infect Dis. 2006 Dec 1. 43(11):1463-7. [QxMD MEDLINE Link]. ... Coxsackie B virus infection can be diagnosed by isolation of the virus in cell culture, detection of virus RNA via polymerase ... Coxsackie virus B1-B6 is the most common isolated variant.  Necrosis of the striated intercostal muscles is visible. in ... Coxsackie B virus infections in New Zealand patients with cardiac and non-cardiac diseases. J Med Virol. 1983. 11(2):131-7. [ ...
NephropathyInfectionAdenovirusCytomegalovirusHepatitis G virInfectionsPolymeraseSimianPolyomavirusesInfluenzaDouble-strandedRecipientsAntibodyViral loadHemorrhagic CystitisGenomeProgressive multifocal leukoencMarburg-VirusTransplant patientsUrineEbolaHighly contagiousAsymptomaticAVIANInfectiousHumanIsolationPolyomaviridaePolyomavirus familyFindingsOutbreaksStrainsClinical2019SerologySerotypeMolecularRarelyGeneticAssaysCORONAVIRUS
- BK polyomavirus (BKV) is a member of the polyomavirus family that can cause transplant-associated complications including nephropathy in kidney transplantation and hemorrhagic cystitis in hematopoietic stem cell transplantation. (roche.com)
- This assay detects and quantifies the level of BK virus (BKV) DNA present in the urine of kidney transplant recipients who are at risk of developing BKV-associated nephropathy or hemorrhagic cystitis leading to decreasing renal function and eventual renal failure. (marshfieldlabs.org)
- After primary infection, the virus can remain inactive, only to possibly reactivate in immunocompromised individuals such as transplant recipients. (roche.com)
- After primary infection, the virus can remain inactive throughout life, only to possibly reactivate in immunocompromised individuals, such as patients who receive solid-organ transplants. (roche.com)
- In the case of brain cancer, no infection has been accepted as directly oncogenic, although a number of viruses and parasites are associated with the malignancy. (cuni.cz)
- Presence of nucleic acid or antigen in semen does not represent the presence of replication-competent or infection-competent virus, which can generally only be demonstration by isolation and culture of virus. (cdc.gov)
- Maximum detection time refers to time from symptom onset (only in viruses that cause acute only, not chronic, infection). (cdc.gov)
- Decline in native kidney function in liver transplant recipients is not associated with BK virus infection. (microbiologyresearch.org)
- The patient was retrospectively diagnosed with Marburg virus infection 10 . (cdc.gov)
- The project included a Phase I clinical trial with AntiBKV, an antibody targeting BK polyomavirus (BKV) infection in renal transplant patients. (yourerie.com)
- Coxsackie B virus infection can be diagnosed by isolation of the virus in cell culture, detection of virus RNA via polymerase chain reaction (PCR) or serologic evaluation of viral antibodies. (medscape.com)
- Similarly, patients with asymptomatic infections may shed the virus for months after they acquire the infection. (medscape.com)
- Further evidence of the benefits associated with antiviral treatment in kidney allograft recipients with chronic hepatitis B virus infection. (ikem.cz)
- Taking everolimus may decrease your ability to fight infection from bacteria, viruses, and fungi and increase the risk that you will get a serious or life-threatening infection. (medlineplus.gov)
- Since his recent move to Stanford, he has developed an interest in understanding the immune response to latent viral infection in human transplant recipients with ongoing work evaluating the responses to cytomegalovirus and BK virus. (stanford.edu)
- Though EBV is the most prevalent opportunistic viral infection among HIV infected individuals, there was no significant association between EBV load, CD4+ T cell counts and HIV-1 virus load. (who.int)
- Managing hepatitis B virus infection in pregnancy and children. (monashhealth.org)
- Black men who have sex with men (MSM) are disproportionately affected by human immunodeficiency virus (HIV) infection, accounting for 38% of all new HIV diagnoses among MSM in the United States in 2016. (cdc.gov)
- Identifying HIV-infected persons who are unaware of their human immunodeficiency virus (HIV) infection status, linking them to care, and reducing health disparities are important national HIV prevention goals ( 1 ). (cdc.gov)
- Viral cystitis - Due to adenovirus or BK virus in select populations. (logicalimages.com)
- Urine polymerase chain reaction (PCR) test results were negative for BK virus, but PCR results for urine and serum adenovirus returned positive on hospital day 3. (consultant360.com)
- Materials and Methods: Multiplex PCR was attempted to detect the opportunistic herpes viruses (HSV-1, HSV-2, VZV, EBV, and CMV), adenovirus and polyoma viruses (JC and BK) in three cocktails of PCR reactions. (who.int)
- This FDA clearance allows Roche to offer healthcare professionals a transplant testing portfolio that includes Cytomegalovirus, Epstein-Barr virus and BK virus so they can simultaneously monitor and improve care for transplant patients who are at risk for these common infections or viral reactivations which can cause further illness or death. (roche.com)
- Additional pathogens causing viral hemorrhagic cystitis include cytomegalovirus, BK virus, and JC virus, though these are rarely seen in immunocompetent persons. (consultant360.com)
Hepatitis G vir1
- Absence of hepatitis C virus and detection of hepatitis G virus/GB virus C RNA sequences in the semen of infected men. (cdc.gov)
- Because the intervention unexpectedly increased rates of BK virus infections, our findings underscore the complexities of targeting peri-transplant inflammation as a strategy to improve KTx outcomes. (asnjournals.org)
- BK-virus infections: a literature review. (microbiologyresearch.org)
- Human adenoviruses are double-stranded DNA viruses that comprise more than 50 serotypes and cause a variety of illnesses, including pharyngitis, gastroenteritis, respiratory tract infections, conjunctivitis, and more rarely, hemorrhagic cystitis, hepatitis, or pancreatitis. (consultant360.com)
- 1 Unlike other respiratory tract viruses, adenoviruses do not demonstrate seasonality, and infections can occur throughout the year. (consultant360.com)
- BACKGROUND BK virus infections amongst immunocompromised sufferers are related to illness of the kidney or urinary bladder. (sigmabioblogs.com)
- FDA evaluated case reports in AERS and determined that the current labeling, which addresses herpes virus infections in the Warnings and Precautions and Adverse Reactions sections of the labeling, is adequate. (medscape.com)
- The sixth European Conference on Infections in Leukemia (ECIL-6) has published guidelines for the prevention, diagnosis, and treatment of BK polyomavirus-associated haemorrhagic cystitis in hematopoietic stem cell transplant (HSCT) recipients. (medscape.com)
- Purpose: Opportunistic viral infections cause increased morbidity and mortality among human immunodeficiency virus (HIV) infected individuals, especially those who are not on antiretroviral treatment. (who.int)
- The cobas BKV Test is a real-time polymerase chain reaction (PCR) test with dual-target technology that provides quantitative accuracy and guards against the risk of sequence variations that may be present in the BK virus. (roche.com)
- Quantitative real-time polymerase chain response detection of BK virus utilizing labeled primers. (sigmabioblogs.com)
- Recombinant BK virus (BKV), JC virus (JCV) and simian virus 40 (SV40) virus-like particles (VLP) were produced in a baculovirus system, and mouse monoclonal antibodies (mAbs) to these proteins were generated using standard methods. (elsevier.com)
- Another example of a polyomavirus is Simian vacuolating virus 40 (SV40), which can infect humans, rodents, and monkeys. (web.app)
- Description: This is Mouse monoclonal FITC conjugated antibody against Influenza B virus NP for WB, ELISA. (mytaq.com)
- belatacept decreases effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic antagonism. (medscape.com)
- ILI surveillance, which began in 2009, monitors the predominant influenza virus strains circulating in outpatient settings and covers all provinces in mainland China, but it is not designed to estimate the disease burden. (who.int)
- Capture of 0.1-um aerosol particles containing viable H1N1 influenza virus by N95 filtering facepiece respirators. (cdc.gov)
- A member of the Poxvaridea family of double-stranded DNA viruses and related to variola (smallpox), it seems Monkey pox is moving out of its endemic area to terrorize the world (2). (drgermophile.com)
- polyomavirus A small icosahedral, double-stranded oncogenic DNA virus of the Papovaviridae family, which may be used to induce experimental tumours in mice. (web.app)
- Renal impairment is a common complication after liver transplantation (LT). While BK polyomavirus (BKV) has been linked to renal failure in kidney transplant recipients, Torque teno virus (TTV) is a surrogate marker for immunosuppression that does not have a clear association with any human disease. (microbiologyresearch.org)
- BK viraemia was detected in 8.7 % of patients with BK viruria up to 4 years after LT. BKV-specific antibodies were detected in 93.6 % of all LT recipients and correlated with BKV viral load in urine. (microbiologyresearch.org)
- Human IgG antibody Laboratories manufactures the large antibody study offers for virus reagents distributed by Genprice. (mytaq.com)
- The Large Antibody Study Offers For Virus reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (mytaq.com)
- Description: This is purified Mouse monoclonal antibody against BK virus VP1 for WB, ELISA. (mytaq.com)
- Description: This is Mouse monoclonal FITC conjugated antibody against Epstein-Barr virus gp 250/350 for WB, ELISA. (mytaq.com)
- Description: This is goat polyclonal antibody against Rubella virus virions for WB, ELISA. (mytaq.com)
- Description: This is purified Mouse monoclonal antibody against Herpes simplex virus, 1&2 gD for WB, ELISA. (mytaq.com)
- Description: This is purified Mouse monoclonal antibody against Herpes simplex virus, type 2 nuclear for WB, ELISA. (essentialbiosafety.info)
- In this phase 2 study, each patient's CSF was examined before each infusion of BK virus-specific T-cell infusion to measure JC viral load. (ajmc.com)
- Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation. (stembook.org)
- Its genome is about 30 kb , which is one of the largest among RNA viruses. (wikizero.com)
Progressive multifocal leukoenc3
- In patients with progressive multifocal leukoencephalopathy (PML), BK virus-specific T-cell infusions have been shown to clear JC virus in the cerebrospinal fluid (CSF) and relieve clinical symptoms, according to results of a study by Muftuoglu et al. (ajmc.com)
- Allogenic BK virus-specific T cells for progressive multifocal leukoencephalopathy. (ajmc.com)
- JC virus is responsible for causing progressive multifocal leukoencephalopathy (PMLE) in immunocompromised people. (web.app)
- 8. Siegert R, Shu HL, Slenczka W. Nachweis des "Marburg-Virus" beim Patienten [in German]. (cdc.gov)
- Testing at CDC/UVRI identified a Marburg virus disease outbreak in the districts of Kabale, Ibanda, Mbarara, and Kampala over a 3 week time period 13 . (cdc.gov)
- A blood sample from Kween District in Eastern Uganda tested positive for Marburg virus. (cdc.gov)
- A fatal suspect case of Marburg virus disease (MVD) was identified in the Ashanti region of Ghana on July 7, 2022. (cdc.gov)
- Siegert R. Marburg Virus. (cdc.gov)
- Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human iInfection. (cdc.gov)
- Forty-five years of Marburg virus research. (cdc.gov)
- Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya. (cdc.gov)
- Kuming BS, Kokoris N. Uveal involvement in Marburg virus disease. (cdc.gov)
- 2019) Marburg virus disease outbreak in Kween District Uganda, 2017: Epidemiological and laboratory findings. (cdc.gov)
- Studies of reservoir hosts for Marburg virus. (cdc.gov)
- The test provides standardised, high-quality results that can help healthcare professionals better assess the risk of complications caused by the BK virus in transplant patients and identify effective treatment options. (roche.com)
- Researchers from the University of Leeds have revealed the structure of a virus which affects kidney and bone marrow transplant patients in near-atomic levels of detail for the first time. (wordpress.com)
- An 'Undetected' test result indicates the absence of BK virus (BKV) DNA in the urine. (marshfieldlabs.org)
- There was no correlation between renal impairment and the detection of BK DNA in urine (OR 0.983). (microbiologyresearch.org)
- Resurgence of Ebola virus disease in guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days. (cdc.gov)
- Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995. (cdc.gov)
- Molecular evidence of sexual transmission of Ebola virus. (cdc.gov)
- Geisbert TW, Bausch DG, Feldmann H. Prospects for immunisation against Marburg and Ebola viruses. (cdc.gov)
- A probable case of Ebola virus haemorrhagic fever in Kenya. (cdc.gov)
- The SARS-related coronavirus was one of several viruses identified by the World Health Organization (WHO) in 2016 as a likely cause of a future epidemic in a new plan developed after the Ebola epidemic for urgent research and development before and during an epidemic towards diagnostic tests , vaccines and medicines . (wikizero.com)
- The Center for Disease Control has issued a medical alert about a highly contagious, potentially dangerous virus that is transmitted orally, by hand, and even electronically. (mjunplugged.com)
- Avian polyomavirus is a papovavirus, which is a highly contagious DNA virus that sometimes leads to diseases such as French molt or the "feather-losing disease" in birds. (web.app)
- Patient 1, after 2 additional infusions, was cleared of the JC virus and remained asymptomatic at 24 months after the last infusion. (ajmc.com)
- A symptomatic, or even an asymptomatic, infected individual could release the virus in the atmosphere, by coughing or sneezing (or even by laborious breathing or speaking), which may still remain active in the atmosphere for a few hours (depending on atmospheric conditions), and on certain surfaces up to 2/3 days - and any uninfected individual, who may later pass through the area, may inhale the virus and get infected. (bk-pbk.in)
- What is a symptom of beak However, one type of human polyomavirus, the Merkel cell polyomavirus, is known to cause a rare form of skin cancer called Merkel cell carcinoma, and other members of the polyomavirus family can Avian polyomavirus is a virus that may cause serious disease or even death in cage birds, particularly in the case of young chicks between one week to two months of age. (web.app)
- The research team at the University's Astbury Centre for Structural Molecular Biology focused on the infectious BK polyomavirus (BKV), using the center's two cryo-electron microscopes to develop the incredibly detailed imaging required. (wordpress.com)
- Astbury Centre Ph.D. researcher Dan Hurdiss, the lead author of the paper, said: "Our structures provide the clearest picture to date of the infectious virus particle. (wordpress.com)
- 1. Kulcsár G, Csata S, Nász I. Investigations into virus carriership in human semen and mouse testicular cells. (cdc.gov)
- Malignant undifferentiated sarcomas were induced in 11 of 15 (73.3%) newborn Syrian hamsters by s.c. inoculation of a recombinant DNA (pBK/c-rasA) containing BK virus (BKV) early region gene and the activated human c-Harvey-ras(c-Ha-ras) oncogene derived from T24 bladder carcinoma. (unife.it)
- These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States. (cdc.gov)
- These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)
- The virus causes PML and other diseases only in cases of immunodeficiency, as in AIDS or during treatment with drugs intended to induce MW polyomavirus (MWPyV, also known as Human polyomavirus 10 and briefly as MXPyV) is a virus of the polyomavirus family that infects human hosts.It was discovered in 2012 and reported independently by several research groups. (web.app)
- Virus isolation from stool, pleural fluid or the pharynx is most specific, but not sensitive, test and can render a positive result for up to 2 weeks after resolution of symptoms. (medscape.com)
- Although seldom performed for the diagnosis of pleurodynia per se, tissue diagnosis can be made by direct detection of the viral antigen or by isolation of RNA virus-specific sequences. (medscape.com)
- Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. (cdc.gov)
- The JC virus comes from the Polyomaviridae family, a virus family with similar antigens and genetic immunogenicity as the BK virus. (ajmc.com)
- BK virus (BKV) is a member of the polyomavirus family that can cause severe transplant-associated complications. (roche.com)
- Magnetic resonance imaging (MRI) provided findings consistent with PML, and a lumbar puncture revealed JC virus load in the CSF. (ajmc.com)
- Two strains of the virus have caused outbreaks of severe respiratory diseases in humans: severe acute respiratory syndrome coronavirus 1 (SARS-CoV or SARS-CoV-1), which caused the 2002-2004 outbreak of severe acute respiratory syndrome (SARS), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causing the ongoing pandemic of COVID-19 . (wikizero.com)
- Severe acute respiratory syndrome-related coronavirus ( SARSr-CoV or SARS-CoV ) [note 1] is a species of virus consisting of many known strains phylogenetically related to severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) that have been shown to possess the capability to infect humans , bats , and certain other mammals . (wikizero.com)
- The key feature of xTAG assays is their high degree of multiplexing, and as such, Luminex sells assay panels such as a Respiratory Virus Panel and Gastrointestinal Pathogen Panel to larger core clinical labs. (genomeweb.com)
- The corona virus (2019-nCoV OR HCOV-19 or CoV2), has emerged in China as the main cause of viral pneumonia (COVID-19, Coronavirus Disease-19). (bvsalud.org)
- Viral serology, in particular syphilis & hepatitis viruses. (stjames.ie)
- One disadvantage of RT-PCR is that the virus serotype cannot be identified. (medscape.com)
- Molecular epidemiology of BK Virus. (stjames.ie)
- About 80% of the world's adult population is infected with BKV, but the virus rarely causes illness in people with a healthy immune system. (wordpress.com)
- Marburg hemorrhagic fever associated with multiple genetic lineages of virus. (cdc.gov)
- Additional restriction fragment length polymorphism (RFLP) assays may provide a simple strategy to identify the virus subtype. (medscape.com)
- The SARS-related coronavirus is an enveloped, positive-sense, single-stranded RNA virus . (wikizero.com)