BK Virus: A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.Polyomavirus Infections: Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).Nephritis, Interstitial: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.JC Virus: A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.Polyomavirus: A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.Kidney Transplantation: The transference of a kidney from one human or animal to another.Simian virus 40: A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.Tumor Virus Infections: Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Ontario: A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Telefacsimile: A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.LondonKidney Diseases: Pathological processes of the KIDNEY or its component tissues.Rationalization: A defense mechanism operating unconsciously, in which the individual attempts to justify or make consciously tolerable, by plausible means, feelings, behavior, and motives that would otherwise be intolerable.Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Urogenital Neoplasms: Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.Herpesvirus 4, Human: The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

A possible contributory role of BK virus infection in neuroblastoma development. (1/481)

The tumor suppressor protein p53 is aberrantly localized to the cytoplasm of neuroblastoma cells, compromising the suppressor function of this protein. Such tumors are experimentally induced in transgenic mice expressing the large tumor (T) antigen of polyomaviruses. The oncogenic mechanisms of T antigen include complex formation with, and inactivation of, the tumor suppressor protein p53. Samples from 18 human neuroblastomas and five normal human adrenal glands were examined. BK virus DNA was detected in all neuroblastomas and none of five normal adrenal glands by PCR. Using DNA in situ hybridization, polyomaviral DNA was found in the tumor cells of 17 of 18 neuroblastomas, but in none of five adrenal medullas. Expression of the large T antigen was detected in the tumor cells of 16 of 18 neuroblastomas, but in none of the five adrenal medullas. By double immunostaining BK virus T antigen and p53 was colocalized to the cytoplasm of the tumor cells. Immunoprecipitation revealed binding between the two proteins. The presence and expression of BK virus in neuroblastomas, but not in normal adrenal medulla, and colocalization and binding to p53, suggest that this virus may play a contributory role in the development of this neoplasm.  (+info)

Concerted expression of BK virus large T- and small t-antigens strongly enhances oestrogen receptor-mediated transcription. (2/481)

Previous studies have shown that the human polyomavirus BK (BKV) genome contains an oestrogen response element (ERE). This isolated element binds its cognate receptor in vitro and can mediate 17beta-oestradiol-induced gene expression when linked to a heterologous promoter. The roles of the ERE- and the AP-1-binding sites in oestrogen receptor-directed transcription from the complete BKV promoter/enhancer (Dunlop strain) have been examined and the effects of the general co-activator CBP and large T- and small t-antigens on oestrogen receptor-mediated transcription have been investigated. A constitutive activated oestrogen receptor stimulated BKV promoter activity in HeLa cells. Mutations in either the ERE- or the AP-1-binding sites did not impair oestrogen receptor-induced activation of the BKV Dunlop promoter, while mutations in both binding motifs almost completely abolished oestrogen receptor-induced transcription. Simultaneous expression of large T- and small t-antigens strongly activated oestrogen receptor-mediated transcription. When expressed separately, only large T-antigen moderately stimulated oestrogen receptor-mediated transcription. The stimulatory effect of large T-antigen on the activity of the oestrogen receptor is probably indirect because no physical interaction between the two proteins was detected in a two-hybrid assay. Large T-antigen abrogated the synergistic effect on transcription between this nuclear receptor and the general co-activator CBP. The findings that the BKV early proteins amplify oestrogen receptor-mediated transcription may have important biological implications in individuals with raised oestrogen concentrations.  (+info)

Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice. (3/481)

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridization revealed that the transgene is stably maintained in all organs of transgenic mice as a tandem insertion in a number of copies ranging from 5 to 20 per cell. In addition, tat and BKV RNA were expressed in all tissues. Transgenic mice developed three types of lesions: 1) tumors, 2) hyperplastic and dysplastic lesions, and 3) non-neoplastic lesions. Tumors of different histotypes, such as lymphomas, adenocarcinomas of skin glands, leiomyosarcomas, skin squamous cell carcinomas, hepatomas, hepatocarcinomas, and cavernous liver hemangiomas, developed in 29% of transgenic animals. The majority of tumors were malignant, invasive, and producing metastases. Conversely, tumors of only two histotypes (lymphomas and adenocarcinomas of skin glands) appeared in control mice. Hyperplastic and dysplastic lesions were more frequent in transgenic than in control mice and involved the skin or its adnexes, the liver and the rectum, indicating multiple targets for the activity of the transgene. Pyelonephritis, frequently complicated with hydronephrosis, inflammatory eye lesions, and amyloid depositions represented the most frequent non-neoplastic lesions detected in transgenic mice. Many of the pathological findings observed in this animal model are comparable to similar lesions appearing in AIDS patients, suggesting a relevant role for Tat in the pathogenesis of such lesions during the course of AIDS.  (+info)

BK and JC viruses in patients with systemic lupus erythematosus: prevalent and persistent BK viruria, sequence stability of the viral regulatory regions, and nondetectable viremia. (4/481)

A role for polyomaviruses in the pathogenesis of systemic lupus erythematosus (SLE) has been suggested. BK virus (BKV) and JC virus (JCV) were demonstrated in single urine specimens from 7 (16%) of 44 and 5 (11%) of 44 patients with SLE and 0/88 and 18 (21%) of 88 matched healthy controls, respectively. During a 1-year follow-up study, episodes of polyomaviruria were detected in 16 (80%) of 20 patients, BKV in 13, and JCV in 3 patients. A group of 12 (60%) of 20 patients demonstrated persistent or recurrent polyomaviruria, BKV viruria (n=9), or JCV viruria (n=3) in 180 (70%) of 256 specimens. Polyomaviruria was not significantly associated with immunosuppressive therapy. The BKV and JCV isolates revealed predominantly stable archetypal regulatory regions over 3 years, indicating viral persistence rather than reinfection as a cause for urinary shedding. The demonstration of nondetectable viremia and stable archetypal BKV and JCV noncoding control regions during persistent viruria argue against the urinary tract as a focus for the creation of rearranged regulatory region variants.  (+info)

JC and BK virus sequences are not detectable in leukaemic samples from children with common acute lymphoblastic leukaemia. (5/481)

Epidemiological evidence suggests that childhood leukaemia, and possibly common acute lymphoblastic leukaemia in particular, may have an infectious aetiology. Smith (1997 J Immunother 20: 89-100) recently suggested that the critical infectious event occurs during pregnancy, and identified the polyoma virus JC as a candidate agent. In the present study we investigated whether genomes from the JC virus, and closely related BK virus, could be detected in leukaemic cells. No positive results were obtained suggesting that JC virus is unlikely to play a direct role in leukaemogenesis.  (+info)

Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC virus and BK virus. (6/481)

A comparison of antibody titers to JC virus (JCV) or BK virus (BKV) was made by hemagglutination inhibition (HI) and enzyme immunoassay (EIA) with 114 human plasma samples. Antibody titers to JCV or BKV determined by HI were lower than those determined by EIA. Nevertheless, as HI titers increased so did EIA titers. When antibody data were compared by the Spearman rank correlation test, highly significant correlations were found between HI and EIA titers. Results obtained by plotting EIA antibody titers for JCV against those for BKV generally showed a reciprocal relationship, i.e., samples with high antibody titers to JCV had lower antibody titers to BKV and vice versa. Some samples, however, had antibody titers to both viruses. Of the samples tested, 25.4% (25 of 114) had HI and EIA antibody titers to JCV and BKV which were identical or closely related. This is not the scenario one would expect for cross-reactive epitopes shared by the two viruses, but one suggesting that these samples were from individuals who had experienced infections by both viruses. Adsorption with concentrated JCV or BKV antigen of sera with high antibody titers to both JCV and BKV and testing by JCV and BKV EIA gave results which support this conclusion. Although 52.6% (51 of 97) of the samples from the Japanese population tested had very high antibody titers (>/=40,960) to either JCV or BKV, none of the samples were found by a dot blot immunoassay to have antibodies which cross-reacted with simian virus 40. The results from this study, in agreement with those of others, suggest that humans infected by JCV or BKV produce antibodies to species-specific epitopes on their VP1 capsid protein, which is associated with hemagglutination and cellular binding.  (+info)

Polyomaviruria in renal transplant patients is not correlated to the cold ischemia period or to rejection episodes. (7/481)

Polyomaviruria was observed in one-third of all renal transplant patients, irrespective of whether their renal grafts came from a living or cadaver donor, and was not correlated to graft rejection episodes. This suggests that the renal graft ischemia period is not the major cause of polyomavirus reactivation and that reactivation of polyomavirus is not a dominant cause of graft rejection.  (+info)

Documenting the epidemiologic patterns of polyomaviruses in human populations by studying their presence in urban sewage. (8/481)

This is the first description, to our knowledge, of the distribution of human polyomavirus and simian virus 40 (SV40) in urban sewage. Using a nested-PCR procedure, we report the detection of human polyomaviruses JC virus (JCV) and BK virus (BKV) but not SV40 in a high percentage of urban sewage samples obtained from widely divergent geographical areas in Europe and Africa. For a total of 28 samples analyzed, JCV was detected in 26, BKV was detected in 22, and none was positive for SV40. All geographical areas showed a high prevalence of these viruses with mean estimated values of JC viral particles per ml on the order of 10(3) in Barcelona (Spain) and Nancy (France) and 10(2) in Pretoria (South Africa) and Umea (Sweden) and mean values of BK viral particles on the order of 10(2) in Pretoria and Barcelona and 10(1) in Nancy and Umea. This compares with estimated mean values of 10(2) to 10(3) for human adenovirus that was evaluated as a control. Nucleotide sequence analysis of the amplified DNA from some of the samples is also presented and represents the sequence of the most abundant JC and BK viral strains in these samples. The nucleotide sequence of the JCV detected was also analyzed in a phylogenetic study and for genomic characterization in the regulatory region. This study has shown that human polyomaviruses are spread in high concentrations in the sewage of different geographical areas and are present in contaminated environments. The frequency and concentration of JCV detected in the environment and the absence of described animal hosts suggest that JCV may be useful as a marker for fecal pollution of anthropogenic origin. The results also support the idea previously described that the strains of JCV are closely related to the ethnic origin of the population studied. The procedure applied should also be useful in future studies of population patterns of viral excretion and as a tool in epidemiological studies for the detection of changes in the prevalence of specific viral pathogens.  (+info)

*BK virus

The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K. The BK virus is similar to ... The BK virus is a member of the polyomavirus family. Past infection with the BK virus is widespread, but significant ... Overview of the BK virus MicrobiologyBytes: Polyomaviruses Reploeg MD, Storch GA, Clifford DB (July 2001). "Bk virus: a ... a disease called BK nephropathy. From 1-10% of renal transplant patients progress to BK virus associated nephropathy (BKVAN) ...

*Anti-dsDNA antibodies

Human immunodeficiency virus, parvovirus B19 and BK virus are known to induce these antibodies. There is little evidence ... Reploeg MD, Storch GA, Clifford DB (July 2001). "Bk virus: a clinical review". Clin. Infect. Dis. 33 (2): 191-202. doi:10.1086/ ... Epstein-Barr virus is also known to induce dsDNA antibodies, as seen after immunisation of animals with EBNA-1 epitopes. Anti- ... Poole BD, Scofield RH, Harley JB, James JA (February 2006). "Epstein-Barr virus and molecular mimicry in systemic lupus ...

*Polyomaviridae

Most of these viruses, such as BK virus and JC virus, are very common and typically asymptomatic in most human populations ... most notably BK virus, JC virus, and SV40. It is essential for proliferation in the viruses that express it and is thought to ... BK virus is associated with nephropathy in renal transplant and non-renal solid organ transplant patients, JC virus with ... A fourteenths virus has been desciribed. Lyon IARC polyoma virus is related to raccoon polyoma virus. The following 13 ...

*Kidney transplantation

BK virus is now being increasingly recognised. Infection is the cause of death in about one third of people with renal ...

*Decoy cells

BK virus nephropathy remains a significant post transplantation complication. Decoy cells alone do not need to be treated since ... Purighalla, R; Shapiro, R; McCauley, J; Randhawa, P (1995). "BK virus infection in a kidney allograft diagnosed by needle ... In patients with decoy cells detected, their sensitivity, specificity, and negative and positive predictive value for BK virus ... Van Aalderen, MC; Heutinck, KM; Huisman, C; Ten Berge, IJ (2012). "BK virus infection in transplant recipients: Clinical ...

*Cidofovir

... shows anti-BK virus activity in a subgroup of transplant recipients. Cidofovir is being investigated as a ... "Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy". Pediatr Transplant. 10 (1 ... It has inhibitory effects on varicella-zoster virus replication in vitro although no clinical trials have been done to date, ... Magee, WC; Hostetler, KY; Evans, DH (August 2005). "Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir ...

*Eugene O. Major

Throughout his career, Major has conducted research on viruses including BK virus, adenoviruses, JC virus, simian virus 40 ( ... Olive, DM; Lampert, M; Major, EO (1980). "Comparison of wild-type BK virus DNA and BK virion DNA rescued from virus-transformed ... Major, E. O.; Di Mayorca, G. (1973). "Malignant Transformation of BHK21 Clone 13 Cells by BK Virus-A Human Papovavirus". ... where he researched papovaviruses such as BK virus with Giampiero Di Mayorca. (The papovaviruses have since been split into two ...

*Immunosuppressive drug

Immunosuppression BK virus Behcet's Disease Discovery and development of mTOR inhibitors N A Gillett; C Chan (2000). " ...

*Urine-diverting dry toilet

BK virus or Simian virus. The Ebola virus may also be found in urine from an infected person. The exact survival time of this ... Vanchiere, John A. (12 January 2005). "Detection of BK virus and simian virus 40 in the urine of healthy children". Journal of ... "Ebola (Ebola Virus Disease)Transmission, Q&As on Transmission". CDC (Centres for Disease Control and Prevention). 20 November ... particular virus in human urine outside of the human body is unclear but probably "up to several days" like with other body ...

*Immudex

It furthermore enables detection for CMV-, EBV-, influenza-, and BK virus specific CD8+ T cells. Dextramer CMV kit - These MHC ... Virus Dextramer collection 1 - provides reagents for detection, quantification and isolation of virus specific T cells. ...

*Agnoprotein

... including two human viruses - BK virus and JC virus - and the simian virus SV40; the BK, JC, and SV40 examples are by far the ... BK virus and JC virus, as well as the simian polyomavirus SV40. Agnoprotein is typically quite short: examples from BK virus, ... Among sequenced BK virus genomes, agnoprotein is the most variable viral protein in amino acid sequence. Differences in tissue ... Its functions are poorly characterized even in well-studied viruses. Null mutant viruses without agnoprotein are generally ...

*Per Villand

degree: At Least Two Types of Control Regions Can Be Found among Naturally Occurring BK Virus Strains". Journal of Virology, ...

*Brincidofovir

BK virus, smallpox, and herpes simplex viruses. Preliminary in vitro tests have also shown it to have potential for the ... Brincidofovir was administered to the first patient diagnosed in the Ebola virus disease outbreak in the US in 2014. The ... "Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses". Expert Rev ... treatment of Ebola virus disease, which is somewhat paradoxical, as Ebola is not a DNA virus. Brincidofovir is currently in ...

*Glomerulosclerosis

Epstein-Barr virus infection BK virus Glomerulosclerosis--WebMD. ...

*Immunosuppression

Immunosuppressive drug Discovery and development of mTOR inhibitors BK virus Interleukin-2 immunotherapy B cell deficiency T ... and viruses Immunodeficiency is also a potential adverse effect of many immunosuppressant drugs, in this sense, the scope of ... and certain chronic infections such as human immunodeficiency virus (HIV). The unwanted effect in non-deliberate ...

*Infections associated with diseases

"BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors". Polyomaviruses and Human ... The virus causing this illness was isolated in 1937. The rash typical of Lyme borreliosis was identified the early 1900s. ... Natelson, BH; Ye, N; Moul, DE; Jenkins, FJ; Oren, DA; Tapp, WN; Cheng, YC (1994). "High titers of anti-Epstein-Barr virus DNA ... Atkinson, RL (2007). "Viruses as an etiology of obesity". Mayo Clinic Proceedings. 82 (10): 1192-8. doi:10.4065/82.10.1192. ...

*BENTA disease

... and may be more susceptible to certain viruses including Epstein-Barr virus, BK virus, and molluscum contagiosum. BENTA disease ... Some patients may not mount protective antibody titers to other vaccines, such as measles and varicella zoster virus. T cell ...

*Trichodysplasia spinulosa

... most relevantly with the nephropathy associated in kidney transplant recipients with the polyomavirus BK virus. Antiviral drugs ... used electron microscopy to identify the presence of virus particles in affected cells consistent with what were at the time ... There is evidence that exposure to the virus is common among healthy adults; estimates of seroprevalence (that is, prevalence ... but viral DNA is rarely detectable there in asymptomatic individuals even if they possess antibodies to the virus indicating ...

*Hemorrhagic cystitis

... though it can result from BK virus as well. A chemical hemorrhagic cystitis can develop when vaginal products are inadvertently ... system are at risk for hemorrhagic cystitis due to either the direct effects of chemotherapy or activation of dormant viruses ...

*JC virus

... and is genetically similar to BK virus and SV40. It was identified by electron microscopy in 1965 by ZuRhein and Chou, and by ... The JC virus or John Cunningham virus is a type of human polyomavirus (formerly known as papovavirus) ... and axons suggests that the virus may travel through axons to increase infectivity. The JCV virus may also be a causative agent ... The virus is very common in the general population, infecting 70% to 90% of humans; most people acquire JCV in childhood or ...

*List of MeSH codes (B04)

... bk virus MeSH B04.909.204.210.620.615.400 --- jc virus MeSH B04.909.204.210.620.615.700 --- simian virus 40 MeSH B04.909. ... bk virus MeSH B04.909.574.204.670.615.400 --- jc virus MeSH B04.909.574.204.670.615.700 --- simian virus 40 MeSH B04.909. ... bk virus MeSH B04.280.640.615.400 --- jc virus MeSH B04.280.640.615.700 --- simian virus 40 MeSH B04.280.650.160 --- ... bk virus MeSH B04.909.675.615.400 --- jc virus MeSH B04.909.675.615.700 --- simian virus 40 MeSH B04.909.777.080 --- ...

*Viracor-IBT Laboratories

BK virus and JC virus, among others. Founded in 1983, IBT's deep expertise in the fields of immunology and allergy enabled the ...

*List of diseases (B)

Montreal type Birdshot chorioretinopathy Birt-Hogg-Dubé syndrome Bixler-Christian-Gorlin syndrome Björnstad syndrome BK virus ...

*Slow virus

JC virus & BK virus only cause disease in immunocompromised patients Transmissible spongiform encephalopathies (TSEs), ... A slow virus is a virus, or a viruslike agent, etiologically associated with a disease, having a long incubation period of ... in protection from these slow viruses. This may be in part because the host has acclimated to the virus, or more likely because ... A slow virus disease is a disease that, after an extended period of latency, follows a slow, progressive course spanning months ...

*BK (disambiguation)

BK channel, an ion channel characterized by its large conductance of potassium ions through cell membranes BK virus, a member ... BK is the common abbreviation for the Burger King chain of fast food restaurants. BK or Bk may also refer to: BK (musician), ( ... of the polyomavirus family Berkelium (Bk), a chemical element Elektronika BK, a series of 16-bit PDP-11-compatible Soviet home ... BK) Brahma Kumaris, a religious movement British Knights, a manufacturer of athletic shoes Federal Criminal Police Office ( ...

*Phage display

Kehoe JW, Kay BK (November 2005). "Filamentous phage display in the new millennium". Chem. Rev. 105 (11): 4056-72. doi:10.1021/ ... viruses that infect bacteria) to connect proteins with the genetic information that encodes them. In this technique, a gene ... "Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro". Proc. Natl. Acad. Sci. U.S.A. 89 (19 ... "In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden ...
The cis-acting elements for the early and late promoters, as well as the enhancer in the prototype strains of human polyomavirus BK (BKV) are located within a 500 bp intergenic region. We previously studied the specificity of protein binding in this region in vitro and showed that the interaction of proteins of the nuclear factor-1 (NF-1) family is crucial for early promoter activity. We have now extended our study to the BKV late promoter. We show that the late promoter activity in HeLa cell extracts is poor compared to the activity of the early promoter. Using a high template to protein ratio, multiple start sites were detected by primer extension analysis. DNase I protection experiments revealed the presence of three NF-1 binding sites in the late side, in addition to those identified previously in the 68 bp repeats and C element. Competition transcription assays using binding sites for NF-1, AP-1, Sp-1 and a complete 68 bp repeat indicated that only the 68 bp repeat and the NF-1 binding site
TY - JOUR. T1 - Results of repeat renal transplantation after graft loss from BK virus nephropathy. AU - Geetha, Duvuru. AU - Sozio, Stephen M.. AU - Ghanta, Mythili. AU - Josephson, Michelle. AU - Shapiro, Ron. AU - Dadhania, Darshana. AU - Hariharan, Sundaram. PY - 2011/10/15. Y1 - 2011/10/15. N2 - Background.: BK virus nephropathy (BKVN) is an important cause of renal graft loss in recent years. The aims of this study are to (1) describe the management of patients undergoing retransplantation after allograft loss in the setting of BKVN and (2) to identify risk factors for BK virus replication in the retransplant. Methods.: This retrospective study compiled data on adult patients undergoing repeat transplantation after previous loss of allograft to BKVN from six US centers. Clinical, laboratory, and histopathologic data for both the transplant that failed because of BKVN and the retransplant were abstracted and reviewed. Results.: A total of 31 patients underwent retransplantation after a ...
Human polyomavirus BK (BKPyV) is the aetiological agent of polyomavirus-associated nephropathy (PVAN) and of hemorrhagic cystitis (HC) while human polyomavirus JC (JCPyV) is associated with progressive multifocal leukoencephalopathy (PML). However, JCPyV can give rise to PVAN and HC and BKPyV has been detected in cerebrospinal fluid samples (CSF) from patients with Central Nervous System (CNS) disease, including PML. During the period 1998- 2011, 2,406 CSF samples from patients with suspected JCPyV infection were tested for the presence of BKPyV, JCPyV, and SV40 large T antigen DNA by a multiplex PCR assay in the National Centre of Microbiology. Twenty neurological patients with at least one BKPyV DNApositive CSF specimen were identified. Firstly, an internally-controlled multiplex real-time PCR was developed and showed to be suitable for the diagnosis of polyomavirus BK and JC infection, providing a sensitive, reproducible and specific quantification of the viral load of both viruses in samples ...
Factors determining the course of BK viral (BKV) infection remain uncertain. We studied the role of BKV subtype distribution in BKV-infected patients after renal transplantation.-. We performed genotyping of BKV subtypes in 180 BKV-infected renal transplant recipients with BKV nephropathy (BKVN, n=69), BKV viremia (n=94), BKV viruria alone (n=17), and in 29 healthy adults and 11 dialysis patients with spontaneous BKV replication in urine. We then tested, if the frquency of certain subtypes corresponded to the severity of the infection: BKV nephropathy, BKV high viremia (,10000 copies/mL), or BKV low viremia (,10000 copies/mL). -. Ib-2 was the most frequent BKV subtype (135/220. 61%) and subtype IV the second in frequency (50/220, 23%); Ib-1 (10%), Ia (5%), II and III (1%) were less frequent. Subtype IV-infected patients had more often BKVN and/or high viremia of ,10000 copies/mL than patients with other subtypes (31/38 versus 78/125, p=0.02). Patients with low viremia of ,10000 copies/mL were ...
This is a unique case of BK virus infection associated with HC in a LT recipient. To our knowledge, this is the first reported case of this association. The prevalence of BK viremia and viruria in LT recipients is low when compared to other solid organ transplant recipients.5 The prevalence of BK viruria in LT recipients has been reported to be 7.8% compared to 26.5% in kidney transplant recipients and 25.5% in heart transplant recipients. The prevalence of BK viremia was 0% in LT compared to 12.2% in kidney transplant recipients and 7% in heart transplant recipients.6. The risk factors that have been identified for BK virus infection in LT recipients include CKD, immunosuppression and previous episode(s) of rejection.7,8 One study found that LT recipients with a history of rejection had BK viremia more frequently (40%) than those without rejection (10.6%).8 Although immunosuppression is a risk factor for BK virus infection, none of the studies have identified any specific immunosuppressive ...
BK polyomavirus (BKV) is widespread among humans, asymptomatically infecting children and then persisting in renal tissue. The transcriptional control region (TCR) of the BKV genome is variable among clinical isolates. Thus, archetypal TCRs with a common basic configuration generally occur in BKV isolates from the urine of immunocompromised patients, but rearranged TCRs that possibly arise from the archetypal configuration have also been detected in clinical specimens. To examine the hypothesis that archetypal strains represent wild-type strains circulating in the human population (the archetype hypothesis), we analysed 145 complete viral genomes amplified directly from the urine of non-immunocompromised individuals worldwide. These genomes included 82, three, two and 58 sequences classified as belonging to subtypes I, II, III and IV, respectively. Rearranged TCRs with long duplications or deletions were detected from two subtype I and two subtype IV genomes, but not from the other 141 genomes (thus,
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The BK polyomavirus (BKPyV) is one of the main human polyomaviruses. After primary infection, it establishes a persistent infection, and acts as an opportunistic pathogen, innocuous in immunocompetent hosts, but causing potentially serious pathology in the context of immunosuppression, in particular in kidney and hematopoietic stem cell graft recipients. Much progress has been made in recent years in the description of virus-cell interactions, but many aspects of viral physiopathology remain mysterious, principally due to the asymptomatic nature of infection in immunocompetent individuals and the lack of an animal model. The characteristics of the antiviral immune response are beginning to become more clearly understood, particularly in kidney transplant patients. Work in these areas is important in order to identify patients at high risk of developing a severe infection. Indeed, in the absence of an effective antiviral therapy few therapeutic options are available, and patient management ...
QBK : Polyomaviruses are small (45 nm, approximately 5,000 bp), DNA-containing viruses and include 3 closely related viruses of clinical significance: Simian virus 40 (SV-40), JC virus (JCV), and BK virus (BKV). SV-40 naturally infects rhesus monkeys but can infect humans, while BKV and JCV cause productive infection only in humans.(1,2) Acquisition of BKV begins in infancy. Serological evidence of infection by BKV is present in 37% of individuals by 5 years of age and over 80% of adolescents.   BKV is an important cause of interstitial nephritis and BKV-associated nephropathy (BKVAN) in recipients of kidney transplants. Up to 5% of renal allograft recipients can be affected at about 40 weeks (range 6-150) posttransplantation.(3) Quantitative PCR analysis of BKV DNA in the plasma is the most widely used blood test for the laboratory diagnosis of BKV-associated nephropathy. Importantly, the presence of BKV DNA in blood reflects the dynamics of the disease: the conversion of plasma from negative
BACKGROUND: The diagnosis and management of BK virus (BKV) reactivation following renal transplantation continues to be a significant clinical problem. Following reactivation of latent virus, impaired cellular immunity enables sustained viral replication to occur in urothelial cells, which potentially leads to the development of BKV-associated nephropathy (BKVAN). Current guidelines recommend regular surveillance for BKV reactivation through the detection of infected urothelial cells in urine (decoy cells) or viral nucleic acid in urine or blood. However, these methods have variable sensitivity and cannot routinely distinguish between different viral subtypes. We therefore asked whether mass spectrometry might be able to overcome these limitations and provide an additional non-invasive technique for the surveillance of BKV and identification of recipients at increased risk of BKVAN. RESULTS: Here we describe a mass spectrometry (MS)-based method for the detection of BKV derived proteins directly
Changes in allograft function and allograft survival rate after BK virus-associated nephropathy (BKVAN) diagnosis. (A) Allograft function deteriorated after BKV
Increased risk of infections and possible malignancies (eg, lymphoma, skin); kidney graft thrombosis; nephrotoxicity; and mortality in heart transplantation. Use in heart transplantation: not recommended. Avoid sun, UV light. Severe hepatic impairment or hereditary disorders (eg, galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption): not recommended. Diabetes. Obtain everolimus, cyclosporine and tacrolimus whole blood concentrations periodically (see full labeling); and trough concentrations during dose adjustments. Monitor CBCs, renal function, urine protein, lipids, blood glucose; and for pneumonitis and serious (eg, bacterial, viral, fungal, protozoal) including opportunistic infections; polyoma virus infections (eg, BK virus-associated nephropathy, and JC virus-associated progressive multiple leukoencephalopathy). Antimicrobial prophylaxis for PCP and CMV recommended. Embryo-fetal toxicity. Pregnancy; avoid. Females of reproductive potential should use highly ...
Mouse monoclonal antibody raised against a full-length recombinant BKV VP1. BKV VP1 (YP_717939.1, 1 a.a. ~ 369 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (MAB3204-M14) - Products - Abnova
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
Our standard of care has been changed from Thymoglobulin to Simulect and now patients were enrolled in this observational trial to gather data on their outcomes related to BK viremia and rejection rates. Two groups of patients were compared.. Retrospective (historical or control) group of subjects: patients who had received a kidney transplant and were inducted with Thymoglobulin prior to study initiation.. Prospective group of subjects: patients who is scheduled to receive kidney transplant and will be inducted with Simulect (Basiliximab).. Inductions in both groups was/is Standard of Care at a time of treatment. ...
Since the cloning of the BK B1 receptor in 1994 by Menke et al., several groups have begun to determine the transduction mechanisms involved in its induction (Bachvarov et al., 1996; Yang and Polgar, 1996; Ni et al., 1998; Schanstra et al., 1998;Phagoo et al., 2001). The 5′-flanking region of the human BK B1 receptor gene bears putative NF-κB as well as activator protein-1 binding motifs, a promoter organization consistent with an activation by cytokines, such as IL-1β or TNF-α (Bachvarov et al., 1996). Using transfected cultured cells, Ni et al. (1998) have demonstrated that NF-κB is involved in the inducible expression of the human BK B1 receptor gene during inflammatory processes. In resting cells, NF-κB is held inactive in the cytosol by association with inhibitory proteins of the I-κB family (Baldwin, 1996). When the NF-κB pathway is activated by agents such as lipopolysaccharide, IL-1β, and TNF-α, a phosphorylation-dependent proteolytic degradation of I-κB is initiated, ...
MACS GMP PepTivator BKV LT is a peptide pool that consists mainly of 15-mer peptides with 11 amino acids overlap. It has been developed for efficient in vitro stimulation and subsequent isolation of BKV LT-specific CD4+ and CD8+ T cells. - Belgique
The BK1 file. We collected the information you should know about the .BK1 file on this page. If you were sent a .BK1 file in an e-mail, but you dont know what to do with it, then you can find help here.
Use this form to contact us and we will get back to you as soon as possible. Alternatively you can email us on [email protected] (general enquiries); [email protected] (press enquiries) or [email protected] (tech transfer enquiries ...
Shop Regency Kee 42 Round Breakroom Table, Grey/Black and 4 M Stack Chairs, Black (TB42RDGYPBK47BK) at Staples. Choose from our wide selection of Regency Kee 42 Round Breakroom Table, Grey/Black and 4 M Stack Chairs, Black (TB42RDGYPBK47BK) and get fast & free shipping on select orders.
Gentaur molecular products has all kinds of products like :search , Brady \ PTL_24_428_BK \ 018391 for more molecular products just contact us
Looking for BRADY Caution Sign,7 x 10In,BK/YEL,No Steps (6FJ87)? Graingers got your back. Price:$8.30. Easy ordering & convenient delivery. Log-in or register for your pricing.
Wilwood makes a wide assortment of small, lightweight master cylinders that are suitable for high performance street and racing applications and they are available in a variety of bore sizes. This page displays MasterCylinder No: 261-13626-BK
Wilwood makes a wide assortment of small, lightweight master cylinders that are suitable for high performance street and racing applications and they are available in a variety of bore sizes. This page displays MasterCylinder No: 260-14244-BK
Looking for Thermo-hygrometers - BK 725? Shop now on our webstore! Jeulin, provider of solutions for technical and scientific education
Results Twenty-five patients developed hemorrhagic cystitis. Pre-transplant BK viruria detected by quantitative PCR was positive in 96 patients. The one-year cumulative incidence of hemorrhagic cystitis was 16% in the PCR-positive group versus 9% in the PCR-negative group (P=0.1). The use of umbilical cord blood or a haploidentical donor was the only significant predictor of the incidence of hemorrhagic cystitis on univariate analysis. There was also a trend for a higher incidence after myeloablative conditioning. Multivariate analysis showed that patients who had a positive PCR pre-transplant and received haploidentical or cord blood grafts with myeloablative conditioning had a significantly higher risk of developing hemorrhagic cystitis (58%) than all other recipients (7%, P,0.001). ...
In recent years the scientific literature in the field of the prostate carcinoma (PCa) pointed out on the genetic heterogeneity and mutations occurring in this tumour, while little attention was given to the causes of PCa onset, in particular infectiuos agents. In this brief commentary, we wish to point out recent advancements done on the role of the human polyomavirus BK (BKPyV) in the development of PCa by harnessing both humoral and cellular immune responses. Altogether, these new insights suggest that BKPyV is involved in the transforming activity during the multistep process of PCa development. Although these findings do not provide evidence for a causal relationship between BKPyV and PCa development, additional investigations with novel techniques will help to make it a concrete event. ...
Bennett, S.M., Jiang, M., and Imperiale, M.J. (2013). Role of cell type-specific ER-associated degradation in polyomavirus trafficking. J. Virol., in press.. Broekema, N.M. and Imperiale, M.J. (2013). miRNA regulation of BK polyomavirus replication during early infection. Proc. Natl. Acad. Sci. USA 110:8200-8205.. Jiang, M., Zhao, L., Gamez, M., and Imperiale, M.J. (2012). Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection. PLoS Pathog. 8(8): e1002898. doi:10.1371/journal.ppat.1002898.. Christensen, J.B., Ewing, S.G., and Imperiale, M.J. (2012). Identification and characterization of a DNA binding domain on the adenovirus IVa2 protein. Virology 433:124-130.. Imperiale, M.J. (2012). Dual-use research after the avian influenza controversy. B. Atom. Sci. http://thebulletin.org/web-edition/op-eds/dual-use-research-after-the-av..... Bennett, S.M., Broekema, N.B., and Imperiale, M.J. (2012). BK polyomavirus: emerging pathogen. Microbes Infect. ...
Immunocompromised patients are at risk for disease caused by infection by some polyomaviruses. To define the prevalence of polyomaviruses in children undergoing transplantation, we collected samples from a longitudinal cohort and tested for the 9 known human polyomaviruses. All were detected; several were present in previously unreported specimen types.
Mouse monoclonal antibody raised against a full-length recombinant BKV VP1. BKV VP1 (YP_717939.1, 1 a.a. ~ 369 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (MAB3204-M19) - Products - Abnova
9780471461029 Our cheapest price for Human Polyomaviruses : Molecular and Clinical Perspectives is not available. Free shipping on all orders over $35.00.
Haemorrhagic cystitis is a diffuse inflammatory condition of the urinary bladder due to an infectious or noninfectious etiology, resulting in bleeding from the bladder mucosa. Chronic and recurrent haemorrhagic cystitis often results from antic...
Es sospita que els Polyomaviruses causen càncer en humans però només el poliomavirus de cèl•lules de Merkel (MCPyV) es carcinògen humà confirmat. Fins a nou poliomavirus en 468 trastorns limfoproliferatius, 1135 càncers de bufeta i 359 leucèmies limfocítica crònica (LLC) shan explorat mitjançant tres estudis cas-control a Espanya. Lexposició viral es va mesurar mitjançant enzyme linked immunosorbent assay amb virus-like-particles i tecnologia múltiplex de serologia fluorescent basada en beads. Dels limfomes explorats, nomes el limfoma difús de cèl•lules b grans (LDCBG) va mostrar una MCPyV seroprevalença significativament 6-cops mes alta (OR=6.10; 95%CI=1.88-19.75) versus controls. Els casos de càncer de bufeta van mostrar elevades seroreactivitats envers BKPyV (OR= 1.37; 95%CI=1.04-1.80) i MCPyV (OR=1.48; 95%CI=1.16-1.88). En LLC, es van observar seroprevalences més baixes per als 9 poliomavirus mesurats (OR rang=0.21-0.70). Els patrons serològics obtinguts en LDCBG y ...
Medical Director, Peritoneal Dialysis and Hemodialysis at Fresenius Kidney Care, Fleet Street. Expertise, Disease and Conditions: Glomerulonephritis, Kidney Transplant, Nephrology, Vasculitis. Research Interests: BK virus nephropathy in renal transplant patients, Renal disease in system... [more]. ...
Vol 4: Bladder Cancer versus Hemorrhagic Cystitis: A Case of Mistaken Identity in a 34-Year-Old Male Undergoing Therapy for Granulomatosis with Polyangiitis.. This article is from Case Reports in Nephrology and Urology, volume 4.AbstractA 34-year-old male was referred for manage. Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - The kinetics of urinary shedding of BK virus in children with renal disease. AU - Yamamoto, Yasuto. AU - Morooka, Masashi. AU - Ihira, Masaru. AU - Yoshikawa, Tetsushi. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Children with renal diseases are typically treated with immunosuppressive drugs, which place them at high risk of reactivation of the BK virus (BKV). Currently, little is known about the impact of immunosuppressive drugs on the kinetics of urinary shedding of BKV and viral reactivation in pediatric patients with renal diseases. Urine samples were collected monthly for 1 year from 20 children (median age, 9 years; range, 4-15 years) with renal diseases and subjected to real-time PCR. Urinary shedding of BKV was detected in 35% (7/20) of the patients, three of these patients having persistent viral DNA excretion (two cases, twelve times, one case, four times) and four having intermittent viral DNA excretion. Thirty-four of the 240 urine samples contained BKV DNA (median copy ...
Behandlingar - Hårvård - Farmaca International - Produkter för hår - Protoplasmina Liv-cellen Bk4 - med Keratin, BotoFarm och hyaluronsyra: LIV CELL SCHAMPO BK4 effektivt schampo efter återuppbyggnaden underhållFörsiktigt renar samtidigt som man eliminerar orenheter utan att påverka hår fiber och respektera dess Fysiologiskt pH. förpackning: 250 ml flaska. CELL LIV MASK BK4särskilda underhåll form efter rekonstruktionDess s ...
Buy ARES M4 Handguard Set (DH-003 X 1 / DH-013 X 4 / DH-008 X 1 / DH-014 X 1) - S (BK) from RedWolf Airsoft. Browse different Accessories by ARES online. Buy ARES M4 Handguard Set (DH-003 X 1 / DH-013 X 4 / DH-008 X 1 / DH-014 X 1) - S (BK) and other airsoft Accessories for cheap prices now. Wholesale is also available at RedWolf Airsoft
Use this form to contact us and we will get back to you as soon as possible. Alternatively you can email us on [email protected] (general enquiries); [email protected] (press enquiries) or [email protected] (tech transfer enquiries ...
Gentaur molecular products has all kinds of products like :search , Biosan \ R_12_10, Rotor for 12 x 10_15 ml tubes \ BS-010208-BK for more molecular products just contact us
Vantec nst-226s3-bk nexstar Vault , 2.5 SATA Antivirus external - EE-V226S3 only at NGR Computers Online Webstore - Browse and Buy online!
Schnell & g nstig: Original Brother LC121VALBPDR LC-121 Tintenpatrone MultiPack Bk,C,M,Y Blister (ca. 300 Seiten) ▷ 500.000 Kunden ✛ 2 Jahre Garantie ✛ 24h Lieferung ➫ Jetzt sparen!
Hemorrhagic cystitis or Haemorrhagic cystitis is defined by lower urinary tract symptoms that include dysuria, hematuria, and hemorrhage. The disease can occur as a complication of cyclophosphamide, ifosfamide and radiation therapy. In addition to hemorrhagic cystitis, temporary hematuria can also be seen in bladder infection or in children as a result of viral infection. Causes of hemorrhagic cystitis include chemotherapy (e.g. cyclophosphamide, Ifosfamide), radiation, or infection. Ifosfamide is the most common cause of hemorrhagic cystitis. Radiation-induced hemorrhagic cystitis develops in similar or smaller patient numbers when compared to cyclophosphamide-induced cases. Adenovirus (particularly serotypes 11 and 21 of subgroup B) is the most common cause of acute viral hemorrhagic cystitis in children, though it can result from BK virus as well. A chemical hemorrhagic cystitis can develop when vaginal products are inadvertently placed in the urethra. Gentian violet douching to treat ...
The purpose of this study is to analyze BK viral infection in salivary gland diseases; specifically, to determine a definitive relationship between BK Virus and HIV associated salivary gland disease (HIVSGD). Participants are adults HIV+SGD+ who will be randomized 1:1 to receive BK Virus antiviral (ciprofloxacin) or placebo for 28 days. Salivary function/protein secretion will be correlated with BK polyomavirus titers. We expect that patients with HIV+SGD+ will have elevated oral BK polyomavirus viral loads and will benefit from Ciprofloxacin ...
Ajay Sharma, MD, Department of Paediatrics, University of Western Ontario, Childrens Hospital, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, Canada N6A 5W9 Tel.: +1 519 685 8500 (ext. 58379) Fax: +1 519 685 8156 E-mail ...
A patient is 6 months post-renal transplant, on tacrolimus (trough levels between 10 and 12 ng/mL), mycophenolate mofetil 1 g bid, and prednisone 7.5 mg daily. Her creatinine jumps from 120 to 200 µmol/L. A renal biopsy is reported as, "Acute polyomavirus nephropathy." How would you treat this patient?. Polyomavirus nephropathy is caused by the BK virus, which lies dormant in the kidney and urinary tract, but can be reactivated following transplantation. It can be detected by looking for decoy cells in the urine, measuring the viral load in blood, or by biopsy. The mainstay of treatment is reduction of immunosuppression. Cidofovir, leflunomide, IVIg and quinolone antibiotics have all been suggested as potential antiviral treatments, but evidence from high-quality studies supporting this is currently lacking.. Cases of BK nephropathy have been reported in non-renal transplant patients, but are quite rare. Nonetheless, this case shows the ability of infections that are usually harmless in ...
A patient is 6 months post-renal transplant, on tacrolimus (trough levels between 10 and 12 ng/mL), mycophenolate mofetil 1 g bid, and prednisone 7.5 mg daily. Her creatinine jumps from 120 to 200 µmol/L. A renal biopsy is reported as, "Acute polyomavirus nephropathy." How would you treat this patient?. Polyomavirus nephropathy is caused by the BK virus, which lies dormant in the kidney and urinary tract, but can be reactivated following transplantation. It can be detected by looking for decoy cells in the urine, measuring the viral load in blood, or by biopsy. The mainstay of treatment is reduction of immunosuppression. Cidofovir, leflunomide, IVIg and quinolone antibiotics have all been suggested as potential antiviral treatments, but evidence from high-quality studies supporting this is currently lacking.. Cases of BK nephropathy have been reported in non-renal transplant patients, but are quite rare. Nonetheless, this case shows the ability of infections that are usually harmless in ...
Dr. Mayur Ramesh discusses what is the best test for diagnosis/monitoring of CMV/BKV infection in transplant recipients; the clinical indications for VL monitoring of CMV/BKV in a transplant recipient and the utility of international standardization for VL monitoring of CMV/BKV. About the Henry Ford Transplant Institute Lecture Series: ...
Different studies suggested an oncogenic potential of the polyomaviruses JC virus, BK virus and simian virus 40, particularly in brain tumors and neuroblastoma, which belong to the most frequent malignancies in children. However, currently available data are controversial, possibly due to the different regional prevalence of the viruses and the detection techniques used.
Looking for online definition of BKV in the Medical Dictionary? BKV explanation free. What is BKV? Meaning of BKV medical term. What does BKV mean?
Nephropathy. The best treatment is to reduce immunosuppression. However, this may lead to graft rejection in a renal transplant patient.. Pre-emptive screening for BK virus in blood and urine after renal transplant are implemented to detect any signs of BK proliferation.. The goal of treatment is complete clearance of BK virus from plasma.. BK virus associated nephropathy can result in transplant graft failure; recurrence of PVAN in the re-transplanted kidney is 12%. Cidofovir is an antiviral drug used for cytomegalovirus (CMV) showed inhibition of BK virus activity in vitro. There are case reports of treating PVAN with cidofovir; however, no randomized or controlled studies have been performed, and efficacy is yet to be determined.. Leflunomide is an immunosuppressive drug approved for use in rheumatoid arthritis. Although used by clinicians and described in case reports, there are no randomized or controlled studies to prove benefit.. Ciprofloxacin is an antibacterial in the fluoroquinolone ...
Selected genes are highlighted in orange, bookmarked genes are green. - Chemical increases gene, - Chemical decreases gene, - Chemical increases and decreases gene simultaneosly, No arrows - gene doesnt interact with the chemical. - Gene should be increased/decreased most of the time and the chemical does it. - Gene should be increased/decreased most of the time but the chemical does the opposite. ...
"Viral hemorrhagic fever" . What Causes Hemorrhagic Cystitis?. Hemorrhagic cystitis is the medical term to describe the sudden appearance of blood in the urine that is associated with pain in the area of the bladder and other irritative bladder
Greenmedinfo.com - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
Buy BENCHMADE BM2550BK for $182.75 with free shipping - Benchmade 2550BK Mini-Reflex AUTO 3.2 inch Black Plain Blade, Aluminum Handles at KnifeCenter
Shop Boss CaressoftPlus™ Executive Series (B9409-BK) at Staples. Choose from our wide selection of Boss CaressoftPlus™ Executive Series (B9409-BK) and get fast & free shipping on select orders.
Photo sequence showing how a beetle (Pleocoma) rights itself. Sequence includes photo numbers: BK0711, BK0712, BK0713, BK0714, BK0715, and BK0716. - Stock Image C003/9974
Sony VAIO FW Series VGNFW275JH - I had bought a sony vaio fw 200 series 6 months bk. Now if I start booting nothing is displayed. as if the system is in - question about PC Laptops
BMX meets gamescom: Razer hat einen wilden Haufen renommierter Gefahrensucher auf die größte Spielemesse der Welt losgelassen. Hier ist das Ergebnis.
Chapter 2..on .queens day ..met a princess trouble and a lot of B-SI had only a few contacts with anyone in Zwolle, a couple of superficial chats and an encounter with Diana who had been very amourous then ignored me without reason or explanation, so I didnt bother talking to women for a while, Zwolle…
I Sverige är Bk-bihac74.com rankad som 247 680, med ett uppskattat värde av < 300 månatliga besökare per månad. Klicka för att se andra data om denna sida.
data":{"to":"exeZfUZMj","roomName":"exeZfUZMj-","info":"{UD:exeZfUZMj,N:5YWU5a2Q5aq95aq9UmFiYml0IE1hIE1hIOeUn+a0u+eyvuWTgeeZvuiyqA==,T:V,SU:\\\/rabbitmama\\\/,I:,R:exeZfUZMj,ST:1,NR:0,BK:N}"},"rscode":0,"result":"OK ...
Author Summary Polyomaviruses occupy a replicative niche in animals from birds to humans. Two human polyomaviruses, BKV and JCV, were discovered in 1971 and within the last two years, three new polyomaviruses have been found in humans: KI (KIV), WU (WUV), and Merkel Cell (MCV) polyomavirus. MCV was identified in Merkel Cell carcinomas, a rare skin cancer. To date, it has not been determined what percentage of the human population is exposed to KIV, WUV, and MCV, and when initial exposure to these viruses occurs. We determined that initial exposure to KIV, WUV, and MCV occurs in childhood, similar to that for the known human polyomaviruses BKV and JCV, and that their prevalence is high. We also found evidence that a monkey virus, Lymphotropic Polyomavirus (LPV), likely has a serologically related human counterpart. Another monkey polyomavirus, SV40, was found at ∼2% prevalence, a level that does not support its role in human disease.
Polyomaviruses are widely distributed in humans and other animal species. Polyomaviruses were initially considered a genus within the family Papovaviridae, which included papillomaviruses and polyomaviruses. Simian virus 40 (SV40) produces renal involvement in its simian host, as do JC virus (JCV) and BK virus (BKV) in humans. The major known site of BKV persistence is the renal tubular epithelium, and persistent infection of renal tubular epithelium cells, like that seen with JCV and with mouse pneumotropic virus (MPtV), appears to involve not a state of viral latency but rather ongoing productive infection at low level. Those which predispose to progressive multifocal leukoencephalopathy (PML) are not fully understood. A group of investigators has attempted to duplicate PCR isolation of polyomaviruses from the same tumor material in different laboratories. In this study, PCR analysis of the same 225 brain tumor samples was carried out in two geographically separated laboratories. Earlier, the use of
Hemorrhagic cystitis is defined by lower urinary tract symptoms that include hematuria and irritative voiding symptoms. It results from damage to the bladders transitional epithelium and blood vessels by toxins, pathogens, radiation, drugs, or disease.
Pathology Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of pathology.
Pathology Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of pathology.
Progressive multifocal leukoencephalopathy (PML) is a highly fatal, demyelinating disease of the brain caused by lytic infection of oligodendrocytes with the JC polyomavirus (JCPyV). Emergence of PML is considered rare and is always associated with an underlying deficit in immune surveillance. In accordance, the majority of PML cases are detected ... read more in patients with HIV-induced severe immunodeficiencies. Fortunately, the introduction of cART significantly reduced the incidence of PML in HIV-infected patients. In 2005, however, a surprising increase in PML cases was observed with the use of monoclonal antibodies, including natalizumab and rituximab. As these therapies modulate the immune system rather than suppressing it, questions were raised regarding the conventional route of JCPyV pathogenesis. Owing to the lack of both animal models, and sufficient in vitro models to sustain effective replication of JCPyV, the mechanisms of JC virus infection remain largely uncertain and current ...
This genus contains viruses, which are detected on the skin (human polyomaviruses 6 and 7) and in the gastrointestinal tract (human polyomavirus 10 (MW polyomavirus); human polyomavirus 11 (STL polyomavirus)).. ...
Many humans have antibodies against simian lymphotropic polyomavirus (LPyV), but its DNA has not been found in humans. Identification of human polyomavirus 9 (HPyV9) led us to compare the seroprevalence and cross-reactivity of LPyV and HpyV9. Results could indicate that humans who have antibodies against LPyV are infected by HPyV9.
We got some great news from the U of M on the First Mates recovery this afternoon. She seems to be recovering her health across the board, which we suspected by watching her stamina and coloring improve greatly since her last release from the hospital. She has less need for the oxygen -- in fact, she may not need it at all, but we have to wait for another clinic visit to determine that. But the real news came from the lab reports.. As you know, the FM has suffered from CMV and BK viral infections; the former can be deadly, and the latter killed her transplanted kidney. Today we heard that her viral load on CMV as dropped to 100, just above a "negative" result. It means that the antivirals have done their work. We also found out that the BK viral load results are negative, which means we can start working to get her back on the transplant list. Her hemolytic anemia appears to be resolving itself, which means the bone marrow has shaken off the affects of the campath. Her hemoglobin levels have ...
the jc virus, or john cunningham virus, is a germ so common that the majority of adults have been exposed to it. the virus was first discovered in 1971, when a doctor found it in the brain of a man wi
BK Fusion is the latest innovation from the companys flagship BK Ultrasound brand. It is the first MRI-fusion prostate biopsy application.
Find the Hopnel Black Classic Pac-A-Derm - S80-220BK at Dennis Kirk. Shop our complete selection of Cruiser Motorcycle parts and accessories including the Hopnel Black Classic Pac-A-Derm - S80-220BK.
Axonal swellings and neurodegeneration in brain, hydrocephalus and premature death. Unlike other mutants, myelin ultrastructure, periodicity and physical stability are normal.. ...
Top ⭐ 18 reasons for Audio-Technica ATH-ES55BK vs Nixon Trooper: 1. Highest frequency: 25000 vs 20000 2. Lowest frequency: 10 vs 20 3. Weight: 120 vs 170
此条目由上海金畔生物科技有限公司发表在未分类分类目录,并贴了20/100 20个/包、384WL、BCB、BK、FB、FIBRONECTIN、NS、W/LID、康宁corning 3848 PLATE标签。将固定链接加入收藏夹 ...
Integrated automated sample preparation and assay setup, with manual transfer to the detection unit, for all molecular testing needs ...
ONLY $9 The Rapoo N1162 is a basic USB ambidextrous mouse suitable for use in offices, schools or at home. It offers a reliable, affordable mouse for day-to-day usage with a comfortable feel and essential functions for easy browsing or office functions.
美國消息】 被視為總統大選前哨戰的「兒童總統投票」自1988年起, 六次大選中有五次「貼中」大選贏家。美國著名兒童時事節目「尼克新聞」宣布全國兒童投票結果, 總統奧巴馬取得65%兒童支持, 大比數打敗只得35%支持率的對手羅姆尼。. 全文…. ...
漫長的暑假還有十多日便完結,是時候與孩子一步一步準備上學的心情,以下介紹的是可愛的書本三文治 ...
TY - JOUR. T1 - ABO-incompatible kidney transplantation is a novel risk factor for BK nephropathy. AU - Bentall, Andrew. AU - Neil, Desley. AU - Sharif, Adnan. AU - Ball, Simon. PY - 2015/2/13. Y1 - 2015/2/13. UR - http://www.scopus.com/inward/record.url?scp=84922906964&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84922906964&partnerID=8YFLogxK. U2 - 10.1097/TP.0000000000000483. DO - 10.1097/TP.0000000000000483. M3 - Letter. C2 - 25651124. AN - SCOPUS:84922906964. VL - 99. SP - e8-e9. JO - Transplantation. JF - Transplantation. SN - 0041-1337. IS - 2. ER - ...
Forty-nine healthy volunteer subjects in the age range 22 - 65 were included in the study and the skin swabs were taken from forearm, inner elbow, behind the ear and forehead. A blood sample was also taken and serum antibodies to viruses were monitored. After DNA extraction, the DNA of 13 human polyomaviruses were amplified with PCR and the products were detected with a Luminex-based assay. Rolling-circle amplification was tested prior to the PCR, but it did not increase the number of positive samples. Additionally, sera were used to study serological responses for the three clinically most significant polyomaviruses, JC polyomavirus (according to the initials of the first patient, JCPyV), Mercel cell polyomavirus (MCPyV) and Trichodysplasia spinulosa polyomavirus (TSPyV ...
A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients. Sixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR. HPV and JCPyV were not detected in any specimens (0/69, 0 %); whereas, BKPyV was detected in 6/69 PCas (8.7 %). We did not find a statistically significant association between the presence of BKPyV and age (p = 0.198) or Gleason score (p = 0.268). In addition, 2/6 (33 %) BKPyV positive specimens showed detectable levels of TAg transcripts. There was no association between HPV or JCPyV presence and prostate cancer
Yin Y, Liao B, Song T, Gao Q, Liu GJ, Wu H, Li H, Zhang B. Interventions for preventing hemorrhagic cystitis in patients undergoing hematopoietic stem cell transplantation. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD009212. DOI: 10.1002/14651858.CD009212. ...
Characterization of WU polyomavirus: We have identified a novel virus referred to as WU virus in the family Polyomaviridae by screening of human respiratory secretions. Two human polyomaviruses, BK and JC, were identified in 1971 and infect the majority of humans around the world. These two viruses are closely related to each other and are both are pathogenic in immunocompromised individuals. Earlier this year, a third polyomavirus, KI, was described in human clinical specimens, although its pathogenicity and prevalence in humans has not yet been established. The discovery of WU virus brings the number of polyomaviruses detected in humans to four. WU differs from BK and JC significantly in its genome sequence and in its relative tissue tropism, suggesting that it is likely to have unique biological properties. This discovery raises many questions for further investigation such as: Is WU virus a human pathogen? If so, what kind of disease does it cause? Where in the body does WU virus reside? At ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
The JC virus is a virus which infects the brain of advanced cancer patients and causes PML-- progressive multifocal leukoencephalopathy. PML can lead to neurologic deficits as indicated in your...
Shop Dainolite 6watt LED Desk Lamp 9 x 21.5 x 5 Black (DLED-621-BK) at Staples. Choose from our wide selection of Dainolite 6watt LED Desk Lamp 9 x 21.5 x 5 Black (DLED-621-BK) and get fast & free shipping on select orders.
Cell transformation by SV40 appears to be a laboratory phenomenon, and many of the tumors caused by polyomaviruses can be thought of as dead-end artifacts of
The expression of BK transcripts during development of the chick auditory epithelium. (A) Cycle-by-cycle amplification data are shown for S16 using serial dilut
Apstrāde - Matu Kopšanas - Farmaca International - Produkti matiem - Protoplasmina Vita ŠŪnu Bk4 Komplekts - Keratin, BotoFarm un hialuronskābe, trausliem matiem un matu sabojāt: ŠAMPŪNS rožu priekšapstrādes Alkaline retreaderMaigi attīra matus, vienlaikus likvidējot piemaisījumus, atverot matus, lai nodrošinātu turpmāko ārstēšanu dziļi darbības svari. PILDVIELASretreader uzpildes darbībasTās novatorisku formulu, beefing uzreiz no matu struktūrā un ar ...
Tripp Lite Cat5e 350MHz Snagless Molded Patch Cable - N001-030-BK - Item #627316 at pcRUSH.com with best price for only $ 9.03 as of Monday, December 18, 2017 - Page 1
Goulds Pump MPN606B3BK1A MPVN High Pressure Vertical Multi-Stage G&L Pumps & Repair Parts Available at www.PumpCatalog.com - Click to Order!
|iframe src=https://onedrive.live.com/embed?cid=4E93DF83B380FC5E&resid=4E93DF83B380FC5E%218534&authkey=AFNHgVjSOfld6bk&em=2 width=650 he ...
Diouf MS, Tall A, Deguenonvo RA, Thiam A, Ndiaye M, Diom ES, Boubé DA, Ndiaye C, Ndiaye BK, Ndiaye IC, Diouf R, Diop EM. (Dakar) ...
a href="http://31postrock.blogspot.com/", ,img border="0" alt="31postrock.blogspot.com" src="https://lh4.googleusercontent.com/-A0-JL_Fgb6I/TkjsSoFNWsI/AAAAAAAAAL8/X2xwfHZ93bk/31postrock%252520small.gif"/, ,/a,,br ...
Polyomaviruses are a group of small, non-enveloped DNA viruses that can infect birds, rodents, and primates. Members of the group include simian virus 40 (SV40) and murine polyomavirus (mPyV) as well as a number of human polyomaviruses such as the BK and JC viruses (BKV and JCV, respectively). Recently, a new human polyomavirus was found to be linked to Merkel cell carcinoma, an aggressive type of skin cancer[1]. All polyomavirus capsids are constructed from 360 copies of the major coat protein, VP1, arranged in pentamers on a T=7 icosahedral lattice[2]. The cell-surface receptors for SV40, mPyV, BKV, JCV, and possibly other polyomaviruses are gangliosides, which are complex, sialic acid-containing sphingolipids that reside primarily in lipid rafts. SV40 uses the ganglioside GM1, BKV binds GD1b and GT1b, and mPyV attaches to GD1a and GT1b[3][4]. Crystal structures are available for complete mPyV particles and for mPyV VP1 pentamers in complex with ganglioside receptor fragments[5][6] as well as ...
Objective: To review the first year of a monthly urine cytology screening service, introduced to identify renal transplant patients at risk of polyoma virus nephropathy (PVN), at an early, potentially treatable, stage.. Methods and results: Monthly urine samples (n = 392) were received from 97/108 transplant recipients in 2005. Of 56 patients with follow-up ,6 months, 20% and 9% had significant (,10 decoy cells/cytospin) and non-significant positive cytology, respectively. The first positive urine samples occurred most commonly in the second and third month post-transplantation and patients with significantly positive samples had higher 3-month and 6-month serum creatinine levels than patients with negative urine cytology (p,0.01). Four patients with positive urine cytology had a subsequent positive plasma BK virus PCR; 3/97 patients had biopsy-proven PVN, all in the third month, 1-6 weeks after first positive urine samples.. Conclusions: Significant PV viruria is common following renal ...
Over the past 8 years, the discovery of 11 new human polyomaviruses (HPyVs) has revived interest in this DNA tumor virus family. Although HPyV infection is widespread and largely asymptomatic, one of these HPyVs, Merkel cell polyomavirus (MCV), is a bona fide human tumor virus. JC virus (JCV), BK virus, HPyV7, and trichodysplasia-spinulosa virus (TSV) can cause nonneoplastic diseases in the setting of immunosuppression. Few specific reagents are available to study the biology of the newly discovered HPyVs. We developed a pan-HPyV-screening method using a cocktail of 3 antibodies that, when combined, recognize T antigen proteins of all HPyVs. We validated detection characteristics of the antibody cocktail by immunoblotting and immunohistochemistry and screened 1,184 cases, including well-defined diseases and tumor tissue microarrays. This assay robustly detected MCV, TSV, JCV, and HPyV7 in etiologically related diseases. We further identified WU polyomavirus in a case of chronic lymphocytic ...
TY - JOUR. T1 - Progressive multifocal leukoencephalopathy. T2 - Investigation of three cases using in situ hybridization with JC virus biotinylated DNA probe. AU - Aksamit, Allen J.. AU - Mourrain, Pascale. AU - Sever, John L.. AU - Major, Eugene O.. PY - 1985/10. Y1 - 1985/10. N2 - Using the technique of in situ DNA‐to‐DNA hybridization, a JC virus biotinylated DNA probe was developed and applied to formalin‐fixed, paraffin‐embedded, or fixed, frozen sections of brain tissue from three subjects with progressive multifocal leukoencephalopathy (PML). Light microscopy was carried out to correlate the presence of JC virus DNA with the selective infection of oligodendrocytes and astrocytes in PML. Oligodendrocytes (lytically infected) showed the greatest evidence of viral DNA. More astrocytes showing bizarre morphological changes had evidence of viral DNA than did astrocytes that were simply reactive. Viral DNA was not evident in vascular endothelial cells using this technique. Viral DNA ...
Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (6 ...

Interferon-α and -β Restrict Polyomavirus JC Replication in Primary Human Fetal Glial Cells: Implications for Progressive...Interferon-α and -β Restrict Polyomavirus JC Replication in Primary Human Fetal Glial Cells: Implications for Progressive...

The Polyomavirus family includes two members, BK virus (BKV) and JC virus (JCV), that naturally infect humans. These viruses ... Human endothelial cells allow passage of an archetypal BK virus (BKV) strain � a tool for cultivation and functional studies ... p53 in polyoma virus transformed REF52 cells. Mor, Orna; Read, Moira; Fried, Mike // Oncogene;12/18/97, Vol. 15 Issue 25, p3113 ... To study the genetic variability of these viruses, an evolutionary analysis of the large T antigen, small t antigen, VP1, VP2 ...
more infohttp://connection.ebscohost.com/c/articles/26240133/interferon-and-restrict-polyomavirus-jc-replication-primary-human-fetal-glial-cells-implications-progressive-multifocal-leukoencephalopathy-therapy

Jc Virus Infection - Articles on Medical Diseases and ConditionsJc Virus Infection - Articles on Medical Diseases and Conditions

BK virus is also in the polyoma virus group. It appears that infection by both viruses occurs during childhood or adolescence, ... Jc Virus Infection. Jul.26, 2009 in Viral Infections The JC virus belongs to the polyoma virus group of the papovavirus family ... One report applied a homemade nucleic acid probe with PCR amplification to urine of JC virus patients and obtained an excellent ... If a patient becomes immunosuppressed, especially during AIDS, reactivated JC virus can infect lymphocytes, be carried to the ...
more infohttp://med-life.net/2009/07/26/jc-virus-infection/

Polyoma BK Virus: An Oncogenic Virus?Polyoma BK Virus: An Oncogenic Virus?

... Syed Hassan,1 Zaid Alirhayim,1 Syed Ahmed,2 and Syed Amer3 ... Syed Hassan, Zaid Alirhayim, Syed Ahmed, and Syed Amer, "Polyoma BK Virus: An Oncogenic Virus?," Case Reports in Nephrology, ...
more infohttps://www.hindawi.com/journals/crin/2013/858139/cta/

BK Virus - Automated - QIAGENBK Virus - Automated - QIAGEN

For quantitative detection of BK virus specific DNA using real-time PCR Mostrar detalhes ... QIAsymphony DSP Virus/Pathogen Kit For automated purification of viral nucleic acids or bacterial/pathogen DNA from 1-96 ...
more infohttps://www.qiagen.com/pt/applications/infectious-disease/bk-virus-automated/

BK Virus - Automated - QIAGENBK Virus - Automated - QIAGEN

For quantitative detection of BK virus specific DNA using real-time PCR Show details ... QIAsymphony DSP Virus/Pathogen Kit For automated purification of viral nucleic acids or bacterial/pathogen DNA from 1-96 ...
more infohttps://www.qiagen.com/fi/products/molecular-diagnostics/infectious-disease/bk-virus-automated/

Bk Virus Infection (Inpatient Care) - What You Need to KnowBk Virus Infection (Inpatient Care) - What You Need to Know

Care guide for Bk Virus Infection (Inpatient Care). Includes: possible causes, signs and symptoms, standard treatment options ... A BK virus (BKV) infection is a common viral infection that usually does not cause problems. The virus normally remains ... Antiviral medicine may be used to kill the BK virus.. *Antirheumatic drugs may be used to help your immune system and kill the ... A kidney biopsy is a procedure to remove a small amount of tissue from your kidney to see if you are infected with the BK virus ...
more infohttps://www.drugs.com/cg/bk-virus-infection-inpatient-care.html

BK virus (Clinical Condition) - ONABK virus (Clinical Condition) - ONA

How does BK virus cause disease? * What other clinical manifestations may help me to diagnose and manage BK virus associated ... BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ... In a patient with BK virus associated diseases, what if a rise of BK serology is detected? *. A rise of BK serology is ...
more infohttps://www.oncologynurseadvisor.com/infectious-diseases/bk-virus-clinical-condition/article/610719/

BK virus (Clinical Condition) - Renal and Urology NewsBK virus (Clinical Condition) - Renal and Urology News

How does BK virus cause disease? * What other clinical manifestations may help me to diagnose and manage BK virus associated ... BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ... BK Virus Screening in Transplant Patients May Be Suboptimal. *Active Surveillance for BK Virus May Help Minimize Nephropathy in ...
more infohttps://www.renalandurologynews.com/infectious-diseases/bk-virus-clinical-condition/article/610718/

QBK - Clinical: BK Virus, Molecular Detection, Quantitative, PCR, PlasmaQBK - Clinical: BK Virus, Molecular Detection, Quantitative, PCR, Plasma

Simian virus 40 (SV-40), JC virus (JCV), and BK virus (BKV). SV-40 naturally infects rhesus monkeys but can infect humans, ... DNA-containing viruses and include 3 closely related viruses of clinical significance: ... Simian virus 40 (SV-40), JC virus (JCV), and BK virus (BKV). SV-40 naturally infects rhesus monkeys but can infect humans, ... To supplement the above data, 30 negative plasma and urine specimens were spiked with BK virus (BKV)-positive control plasmid ...
more infohttps://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83187

BK virus - WikipediaBK virus - Wikipedia

The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K. The BK virus is similar to ... The BK virus is a member of the polyomavirus family. Past infection with the BK virus is widespread, but significant ... Overview of the BK virus MicrobiologyBytes: Polyomaviruses Reploeg MD, Storch GA, Clifford DB (July 2001). "Bk virus: a ... a disease called BK nephropathy. From 1-10% of renal transplant patients progress to BK virus associated nephropathy (BKVAN) ...
more infohttps://en.wikipedia.org/wiki/BK_virus

Anti-BK Virus Immune Response and Kidney Transplantation - Full Text View - ClinicalTrials.govAnti-BK Virus Immune Response and Kidney Transplantation - Full Text View - ClinicalTrials.gov

Anti-BK Virus Immune Response and Kidney Transplantation (BKv). The recruitment status of this study is unknown. The completion ... BK virus infections are very frequent during months following a kidney transplantation: a viral reactivation is observed for ... Role of Specific Immune Cellular Response in the Control of BK Virus Infection: Prospective Study, Monocentric and Longitudinal ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01109186?recr=Open&intr=kidney+transplantation&rank=19

Anti-BK Virus Immune Response and Kidney Transplantation - Full Text View - ClinicalTrials.govAnti-BK Virus Immune Response and Kidney Transplantation - Full Text View - ClinicalTrials.gov

Anti-BK Virus Immune Response and Kidney Transplantation (BKv). The safety and scientific validity of this study is the ... BK virus infections are very frequent during months following a kidney transplantation: a viral reactivation is observed for ... Role of Specific Immune Cellular Response in the Control of BK Virus Infection: Prospective Study, Monocentric and Longitudinal ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01109186?recr=Open&intr=kidney+transplantation&rank=15

BK virus (Clinical Condition) - Cancer Therapy AdvisorBK virus (Clinical Condition) - Cancer Therapy Advisor

BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... How does BK virus cause disease?*What other clinical manifestations may help me to diagnose and manage BK virus associated ... How does BK virus cause disease?. * BK virus primary infection occurs in childhood. Primary infection is asymptomatic. ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ...
more infohttps://www.cancertherapyadvisor.com/home/decision-support-in-medicine/infectious-diseases/bk-virus-clinical-condition/

Kidney Patient Guide • View topic - BK virusKidney Patient Guide • View topic - BK virus

I have 3 different viruses post transplant - BK virus, EB virus and CM virus and they knew I had at least one of these at low ( ... BK virus. by olive » Thu May 19, 2016 5:39 pm Hi everyone, im new to this group can anyone tell me about the bk virus as ive ... How are you all going witb the bk virus? He has me to ask you all....when he was first told he had BK he had a sore throat and ... BK virus. This is the forum for the Kidney Patient Guide. We welcome feedback about the site and any information that may be of ...
more infohttp://www.kidneypatientguide.org.uk/forum/viewtopic.php?p=72776

Kidney Patient Guide • View topic - BK virusKidney Patient Guide • View topic - BK virus

I have 3 different viruses post transplant - BK virus, EB virus and CM virus and they knew I had at least one of these at low ( ... BK virus. by olive » Thu May 19, 2016 5:39 pm Hi everyone, im new to this group can anyone tell me about the bk virus as ive ... How are you all going witb the bk virus? He has me to ask you all....when he was first told he had BK he had a sore throat and ... BK virus. This is the forum for the Kidney Patient Guide. We welcome feedback about the site and any information that may be of ...
more infohttp://www.kidneypatientguide.org.uk/forum/viewtopic.php?p=73168

Early Events during BK Virus Entry and Disassembly | Journal of VirologyEarly Events during BK Virus Entry and Disassembly | Journal of Virology

BK virus (BKV) is a member of the Polyomaviridae family, which also includes the well-studied simian virus 40 (SV40) and human ... Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV). Adv. Exp. Med. Biol. 577:19-45. ... Early Events during BK Virus Entry and Disassembly. Mengxi Jiang, Johanna R. Abend, Billy Tsai, Michael J. Imperiale ... Early Events during BK Virus Entry and Disassembly Message Subject (Your Name) has forwarded a page to you from Journal of ...
more infohttps://jvi.asm.org/content/83/3/1350?ijkey=714a0f9d8f984f744336fd192a5bd32723c4efc4&keytype2=tf_ipsecsha

BK Virus, Quantitative PCRBK Virus, Quantitative PCR

BK Virus DNA, Quant Source. PROMPT. N. 31208-2. 2002302. BK Virus DNA, Quant copy/mL. Resultable. N. cpy/mL. XXXXXXXXX. 48309-9 ... BK Virus DNA, Quant Interp. Resultable. N. 47251-4. For questions regarding the Interface Map, please contact interface.support ... BK Virus DNA, Quant copy/mL. 48309-9. * Component test codes cannot be used to order tests. The information provided here is ... BK Virus DNA, Quantitation. Resultable. N. log. X.X. 43201-3. 0093241. ...
more infohttp://ltd.aruplab.com/Tests/Pub/0090067

BK virus (Clinical Condition)BK virus (Clinical Condition)

How does BK virus cause disease? * What other clinical manifestations may help me to diagnose and manage BK virus associated ... BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ... In a patient with BK virus associated diseases, what if a rise of BK serology is detected? *. A rise of BK serology is ...
more infohttps://www.clinicalpainadvisor.com/infectious-diseases/bk-virus-clinical-condition/article/610723/

Donor-derived and BK virus positive urologic cancers after renal transplantationDonor-derived and BK virus positive urologic cancers after renal transplantation

... Hellström, Vivan Uppsala University, ... Five of eleven cancers of the urinary tract were BK-virus positive. Allograft immune response against these tumours offer new ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:916458

BK virus (Clinical Condition)BK virus (Clinical Condition)

How does BK virus cause disease? * What other clinical manifestations may help me to diagnose and manage BK virus associated ... BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ... In a patient with BK virus associated diseases, what if a rise of BK serology is detected? *. A rise of BK serology is ...
more infohttp://www.thecardiologyadvisor.com/infectious-diseases/bk-virus-clinical-condition/article/610724/

BK virus as a mediator of graft dysfunction following kidney transplantationBK virus as a mediator of graft dysfunction following kidney transplantation

BK virus is a significant risk factor for kidney allograft dysfunction and loss among renal transplant recipients. Currently, ... BK can also be seen in the native kidneys of pancreas, heart, lung and liver transplant recipients, suggesting that BK ... Early screening for BK combined with reduction of immunosuppression remains the mainstay of treatment for BK viraemia. New ... In this review, we discuss diagnostic challenges and current treatment options for BK in kidney transplant recipients. ...
more infohttps://insights.ovid.com/cootr/201708000/00075200-201708000-00004

JCM | Free Full-Text | Higher Incidence of BK Virus Nephropathy in Pediatric Kidney Allograft Recipients with Alport SyndromeJCM | Free Full-Text | Higher Incidence of BK Virus Nephropathy in Pediatric Kidney Allograft Recipients with Alport Syndrome

BK viremia was defined as a BK viral load ,100 copies/mL in blood. Among 168 patients assessed for BK virus status, 30 patients ... Every patient with BK viremia and Alport syndrome developed BKVN, while only 11.1% of patients with BK viremia progressed to ... The study investigated the incidence, risk factors, and clinical outcomes of BK viremia and BKVN in a Korean population of ... BKVN was defined as biopsy-proven BKVN or plasma BK viral loads ,10,000 copies/mL for ,3 weeks. ...
more infohttps://www.mdpi.com/2077-0383/8/4/491

Polyoma BK Virus, PCR, Quantitative, Urine - Medical Laboratory Tests - Seach, Database, InformationPolyoma BK Virus, PCR, Quantitative, Urine - Medical Laboratory Tests - Seach, Database, Information

Information about Polyoma BK Virus, PCR, Quantitative, Urine. Search our extensive database of medical/laboratory tests and ... Polyoma BK Virus, PCR, Quantitative, Urine. a.k.a. BKV, Polyoma BK Virus, Polyomavirus, BK virus ...
more infohttps://www.findacode.com/medical-lab-tests/medical-lab-test.html?name=Polyoma%20BK%20Virus,%20PCR,%20Quantitative,%20Urine&id=55c00b0d-8c3d-457c-8105-90767b9cc5c2
  • Every patient with BK viremia and Alport syndrome developed BKVN, while only 11.1% of patients with BK viremia progressed to BKVN in the absence of Alport syndrome. (mdpi.com)
  • The virus then disseminates to the kidneys and urinary tract where it persists for the life of the individual. (wikipedia.org)
  • BK can also be seen in the native kidneys of pancreas, heart, lung and liver transplant recipients, suggesting that BK screening measures should be employed to other solid organ transplant recipients. (ovid.com)
  • BK virus (BKV) is a member of the Polyomaviridae family, which also includes the well-studied simian virus 40 (SV40) and human JC virus (JCV) ( 21 ). (asm.org)
  • A kidney biopsy is a procedure to remove a small amount of tissue from your kidney to see if you are infected with the BK virus. (drugs.com)
  • BK viral load levels in the patient steadily increased and exceeded those of the control CLL patients. (eur.nl)
  • It is thought that up to 80% of the population contains a latent form of this virus, which remains latent until the body undergoes some form of immunosuppression. (wikipedia.org)
  • The number of copies of BK has now reduced. (kidneypatientguide.org.uk)
  • If the assay DETECTED the presence of the virus but was not able to accurately quantify the number of copies, the test result will be reported as 'Not Quantified. (aruplab.com)
  • BKV is the consequence of modern potent immunosuppression aimed at reducing acute rejection and improving allograft survival which suppresses the immune system so well that dormant and or caught viruses can take hold. (kidneypatientguide.org.uk)
  • Early screening for BK combined with reduction of immunosuppression remains the mainstay of treatment for BK viraemia. (ovid.com)
  • Tan SC et al (2010) Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. (springer.com)
  • Reploeg MD, Storch GA, Clifford DB (2001) BK virus: a clinical review. (springer.com)
  • Both of these viruses can be identified and differentiated from each other by carrying out serological tests using specific antibodies or by using a PCR based genotyping approach. (wikipedia.org)
  • Epstein-Barr virus is also known to induce dsDNA antibodies, as seen after immunisation of animals with EBNA-1 epitopes. (wikipedia.org)
  • BK virus is a significant risk factor for kidney allograft dysfunction and loss among renal transplant recipients. (ovid.com)
  • In this review, we discuss diagnostic challenges and current treatment options for BK in kidney transplant recipients. (ovid.com)
  • If your immune system becomes weak, the virus may become active and you may have symptoms. (drugs.com)
  • The virus normally remains inactive in your body when your immune system is strong. (drugs.com)
  • Antirheumatic drugs may be used to help your immune system and kill the BK virus. (drugs.com)
  • Human primary TEC and peripheral blood mononuclear cells were infected with BKV Dunlop strain or other viruses. (ovid.com)
  • Gupta N, Lawrence RM, Nguyen C, Modica RF (2015) Review article: BK virus in systemic lupus erythematosus. (springer.com)