Bk virus. Medical search

Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).

A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.

Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.

A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.

A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.

A family of small, non-enveloped DNA viruses, infecting mainly MAMMALS, and containing a single genus: POLYOMAVIRUS.

A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.

Viruses whose genetic material is RNA.

Deoxyribonucleic acid that makes up the genetic material of viruses.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.

Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.

Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

The transference of a kidney from one human or animal to another.

Process of growing viruses in live animals, plants, or cultured cells.

The functional hereditary units of VIRUSES.

The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).

Substances elaborated by viruses that have antigenic activity.

A general term for diseases produced by viruses.

The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.

Viruses parasitic on plants higher than bacteria.

Viruses whose nucleic acid is DNA.

Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.

The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.

A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.

The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.

Pathological processes of the KIDNEY or its component tissues.

An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.

A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.

The presence of viruses in the blood.

Proteins found in any species of virus.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.

Established cell cultures that have the potential to propagate indefinitely.

The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.

A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE). It can infect birds and mammals. In humans, it is seen most frequently in Africa, Asia, and Europe presenting as a silent infection or undifferentiated fever (WEST NILE FEVER). The virus appeared in North America for the first time in 1999. It is transmitted mainly by CULEX spp mosquitoes which feed primarily on birds, but it can also be carried by the Asian Tiger mosquito, AEDES albopictus, which feeds mainly on mammals.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.

The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.

Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

Biological activities of viruses and their interactions with the cells they infect.

Ribonucleic acid that makes up the genetic material of viruses.

The type species of VESICULOVIRUS causing a disease symptomatically similar to FOOT-AND-MOUTH DISEASE in cattle, horses, and pigs. It may be transmitted to other species including humans, where it causes influenza-like symptoms.

Proteins that form the CAPSID of VIRUSES.

Immunoglobulins produced in response to VIRAL ANTIGENS.

The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.

Viruses that produce tumors.

A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.

The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.

Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.

The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.

A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.

Viruses which produce a mottled appearance of the leaves of plants.

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.

A species in the genus HEPATOVIRUS containing one serotype and two strains: HUMAN HEPATITIS A VIRUS and Simian hepatitis A virus causing hepatitis in humans (HEPATITIS A) and primates, respectively.

A species of ALPHAVIRUS isolated in central, eastern, and southern Africa.

Group of alpharetroviruses (ALPHARETROVIRUS) producing sarcomata and other tumors in chickens and other fowl and also in pigeons, ducks, and RATS.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.

The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).

The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.

Viruses whose taxonomic relationships have not been established.

Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.

A major class of calcium activated potassium channels whose members are voltage-dependent. MaxiK channels are activated by either membrane depolarization or an increase in intracellular Ca(2+). They are key regulators of calcium and electrical signaling in a variety of tissues.

The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.

The relationships of groups of organisms as reflected by their genetic makeup.

A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.

The type species of ORBIVIRUS causing a serious disease in sheep, especially lambs. It may also infect wild ruminants and other domestic animals.

Virus diseases caused by the ORTHOMYXOVIRIDAE.

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.

A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.

A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.

An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)

Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.

Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)

The outer protein protective shell of a virus, which protects the viral nucleic acid.

The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.

A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.

The type species of TOBAMOVIRUS which causes mosaic disease of tobacco. Transmission occurs by mechanical inoculation.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.

Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.

The type species of LEPORIPOXVIRUS causing infectious myxomatosis, a severe generalized disease, in rabbits. Tumors are not always present.

Inactivation of viruses by non-immune related techniques. They include extremes of pH, HEAT treatment, ultraviolet radiation, IONIZING RADIATION; DESICCATION; ANTISEPTICS; DISINFECTANTS; organic solvents, and DETERGENTS.

A species of ORTHOPOXVIRUS that is the etiologic agent of COWPOX. It is closely related to but antigenically different from VACCINIA VIRUS.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

A species of ORTHOPOXVIRUS causing infections in humans. No infections have been reported since 1977 and the virus is now believed to be virtually extinct.

Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.

The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.

A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.

Elements of limited time intervals, contributing to particular results or situations.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

A species of ALPHAVIRUS causing an acute dengue-like fever.

Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.

The type species in the genus NOROVIRUS, first isolated in 1968 from the stools of school children in Norwalk, Ohio, who were suffering from GASTROENTERITIS. The virions are non-enveloped spherical particles containing a single protein. Multiple strains are named after the places where outbreaks have occurred.

An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A collection of single-stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Biological properties, processes, and activities of VIRUSES.

The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.

Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

Genotypic differences observed among individuals in a population.

A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.

The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.

Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.

A subgroup of the genus FLAVIVIRUS that causes encephalitis and hemorrhagic fevers and is found in eastern and western Europe and the former Soviet Union. It is transmitted by TICKS and there is an associated milk-borne transmission from viremic cattle, goats, and sheep.

A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.

Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).

A species of GAMMARETROVIRUS causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE).

Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).

The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.

Specific hemagglutinin subtypes encoded by VIRUSES.

A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. Airborne transmission is common.

Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.

Any of the viruses that cause inflammation of the liver. They include both DNA and RNA viruses as well viruses from humans and animals.

An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.

Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.

The type species of PARAPOXVIRUS which causes a skin infection in natural hosts, usually young sheep. Humans may contract local skin lesions by contact. The virus apparently persists in soil.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.

A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).

A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes.

A positive-stranded RNA virus species in the genus HEPEVIRUS, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).

A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.

A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.

The type species of BETARETROVIRUS commonly latent in mice. It causes mammary adenocarcinoma in a genetically susceptible strain of mice when the appropriate hormonal influences operate.

An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)

Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.

Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.

A group of replication-defective viruses, in the genus GAMMARETROVIRUS, which are capable of transforming cells, but which replicate and produce tumors only in the presence of Murine leukemia viruses (LEUKEMIA VIRUS, MURINE).

Viruses whose hosts are in the domain ARCHAEA.

INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 7 and neuraminidase 7. The H7N7 subtype produced an epidemic in 2003 which was highly pathogenic among domestic birds (POULTRY). Some infections in humans were reported.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

The type species of the genus AVIPOXVIRUS. It is the etiologic agent of FOWLPOX.

Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.

A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.

The type species of DELTARETROVIRUS that causes a form of bovine lymphosarcoma (ENZOOTIC BOVINE LEUKOSIS) or persistent lymphocytosis.

A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.

Bleeding or escape of blood from a vessel.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

A species of HENIPAVIRUS first identified in Australia in 1994 in HORSES and transmitted to humans. The natural host appears to be fruit bats (PTEROPUS).

The interactions between a host and a pathogen, usually resulting in disease.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.

Nucleic acid sequences involved in regulating the expression of genes.

The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.

A species in the ORTHOBUNYAVIRUS genus of the family BUNYAVIRIDAE. A large number of serotypes or strains exist in many parts of the world. They are transmitted by mosquitoes and infect humans in some areas.

The sum of the weight of all the atoms in a molecule.

A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.

Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).

Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

A species of MORBILLIVIRUS causing distemper in dogs, wolves, foxes, raccoons, and ferrets. Pinnipeds have also been known to contract Canine distemper virus from contact with domestic dogs.

Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.

Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.

A species of MORBILLIVIRUS causing cattle plague, a disease with high mortality. Sheep, goats, pigs, and other animals of the order Artiodactyla can also be infected.

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 7 and neuraminidase 9. This avian origin virus was first identified in humans in 2013.

Sites on an antigen that interact with specific antibodies.

A defective virus, containing particles of RNA nucleoprotein in virion-like form, present in patients with acute hepatitis B and chronic hepatitis. It requires the presence of a hepadnavirus for full replication. This is the lone species in the genus Deltavirus.

The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.

An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

A species of ORTHOPOXVIRUS causing an epidemic disease among captive primates.

The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.

An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.

Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.

The lone species of the genus Asfivirus. It infects domestic and wild pigs, warthogs, and bushpigs. Disease is endemic in domestic swine in many African countries and Sardinia. Soft ticks of the genus Ornithodoros are also infected and act as vectors.

Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.

A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the virions have both HEMAGGLUTININ and NEURAMINIDASE activities and encode a non-structural C protein. SENDAI VIRUS is the type species.

A species in the group RETICULOENDOTHELIOSIS VIRUSES, AVIAN of the genus GAMMARETROVIRUS that causes a chronic neoplastic and a more acute immunosuppressive disease in fowl.

Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.

A possible contributory role of BK virus infection in neuroblastoma development. (1/481)

The tumor suppressor protein p53 is aberrantly localized to the cytoplasm of neuroblastoma cells, compromising the suppressor function of this protein. Such tumors are experimentally induced in transgenic mice expressing the large tumor (T) antigen of polyomaviruses. The oncogenic mechanisms of T antigen include complex formation with, and inactivation of, the tumor suppressor protein p53. Samples from 18 human neuroblastomas and five normal human adrenal glands were examined. BK virus DNA was detected in all neuroblastomas and none of five normal adrenal glands by PCR. Using DNA in situ hybridization, polyomaviral DNA was found in the tumor cells of 17 of 18 neuroblastomas, but in none of five adrenal medullas. Expression of the large T antigen was detected in the tumor cells of 16 of 18 neuroblastomas, but in none of the five adrenal medullas. By double immunostaining BK virus T antigen and p53 was colocalized to the cytoplasm of the tumor cells. Immunoprecipitation revealed binding between the two proteins. The presence and expression of BK virus in neuroblastomas, but not in normal adrenal medulla, and colocalization and binding to p53, suggest that this virus may play a contributory role in the development of this neoplasm. (+info)

Concerted expression of BK virus large T- and small t-antigens strongly enhances oestrogen receptor-mediated transcription. (2/481)

Previous studies have shown that the human polyomavirus BK (BKV) genome contains an oestrogen response element (ERE). This isolated element binds its cognate receptor in vitro and can mediate 17beta-oestradiol-induced gene expression when linked to a heterologous promoter. The roles of the ERE- and the AP-1-binding sites in oestrogen receptor-directed transcription from the complete BKV promoter/enhancer (Dunlop strain) have been examined and the effects of the general co-activator CBP and large T- and small t-antigens on oestrogen receptor-mediated transcription have been investigated. A constitutive activated oestrogen receptor stimulated BKV promoter activity in HeLa cells. Mutations in either the ERE- or the AP-1-binding sites did not impair oestrogen receptor-induced activation of the BKV Dunlop promoter, while mutations in both binding motifs almost completely abolished oestrogen receptor-induced transcription. Simultaneous expression of large T- and small t-antigens strongly activated oestrogen receptor-mediated transcription. When expressed separately, only large T-antigen moderately stimulated oestrogen receptor-mediated transcription. The stimulatory effect of large T-antigen on the activity of the oestrogen receptor is probably indirect because no physical interaction between the two proteins was detected in a two-hybrid assay. Large T-antigen abrogated the synergistic effect on transcription between this nuclear receptor and the general co-activator CBP. The findings that the BKV early proteins amplify oestrogen receptor-mediated transcription may have important biological implications in individuals with raised oestrogen concentrations. (+info)

Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice. (3/481)

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridization revealed that the transgene is stably maintained in all organs of transgenic mice as a tandem insertion in a number of copies ranging from 5 to 20 per cell. In addition, tat and BKV RNA were expressed in all tissues. Transgenic mice developed three types of lesions: 1) tumors, 2) hyperplastic and dysplastic lesions, and 3) non-neoplastic lesions. Tumors of different histotypes, such as lymphomas, adenocarcinomas of skin glands, leiomyosarcomas, skin squamous cell carcinomas, hepatomas, hepatocarcinomas, and cavernous liver hemangiomas, developed in 29% of transgenic animals. The majority of tumors were malignant, invasive, and producing metastases. Conversely, tumors of only two histotypes (lymphomas and adenocarcinomas of skin glands) appeared in control mice. Hyperplastic and dysplastic lesions were more frequent in transgenic than in control mice and involved the skin or its adnexes, the liver and the rectum, indicating multiple targets for the activity of the transgene. Pyelonephritis, frequently complicated with hydronephrosis, inflammatory eye lesions, and amyloid depositions represented the most frequent non-neoplastic lesions detected in transgenic mice. Many of the pathological findings observed in this animal model are comparable to similar lesions appearing in AIDS patients, suggesting a relevant role for Tat in the pathogenesis of such lesions during the course of AIDS. (+info)

BK and JC viruses in patients with systemic lupus erythematosus: prevalent and persistent BK viruria, sequence stability of the viral regulatory regions, and nondetectable viremia. (4/481)

A role for polyomaviruses in the pathogenesis of systemic lupus erythematosus (SLE) has been suggested. BK virus (BKV) and JC virus (JCV) were demonstrated in single urine specimens from 7 (16%) of 44 and 5 (11%) of 44 patients with SLE and 0/88 and 18 (21%) of 88 matched healthy controls, respectively. During a 1-year follow-up study, episodes of polyomaviruria were detected in 16 (80%) of 20 patients, BKV in 13, and JCV in 3 patients. A group of 12 (60%) of 20 patients demonstrated persistent or recurrent polyomaviruria, BKV viruria (n=9), or JCV viruria (n=3) in 180 (70%) of 256 specimens. Polyomaviruria was not significantly associated with immunosuppressive therapy. The BKV and JCV isolates revealed predominantly stable archetypal regulatory regions over 3 years, indicating viral persistence rather than reinfection as a cause for urinary shedding. The demonstration of nondetectable viremia and stable archetypal BKV and JCV noncoding control regions during persistent viruria argue against the urinary tract as a focus for the creation of rearranged regulatory region variants. (+info)

JC and BK virus sequences are not detectable in leukaemic samples from children with common acute lymphoblastic leukaemia. (5/481)

Epidemiological evidence suggests that childhood leukaemia, and possibly common acute lymphoblastic leukaemia in particular, may have an infectious aetiology. Smith (1997 J Immunother 20: 89-100) recently suggested that the critical infectious event occurs during pregnancy, and identified the polyoma virus JC as a candidate agent. In the present study we investigated whether genomes from the JC virus, and closely related BK virus, could be detected in leukaemic cells. No positive results were obtained suggesting that JC virus is unlikely to play a direct role in leukaemogenesis. (+info)

Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC virus and BK virus. (6/481)

A comparison of antibody titers to JC virus (JCV) or BK virus (BKV) was made by hemagglutination inhibition (HI) and enzyme immunoassay (EIA) with 114 human plasma samples. Antibody titers to JCV or BKV determined by HI were lower than those determined by EIA. Nevertheless, as HI titers increased so did EIA titers. When antibody data were compared by the Spearman rank correlation test, highly significant correlations were found between HI and EIA titers. Results obtained by plotting EIA antibody titers for JCV against those for BKV generally showed a reciprocal relationship, i.e., samples with high antibody titers to JCV had lower antibody titers to BKV and vice versa. Some samples, however, had antibody titers to both viruses. Of the samples tested, 25.4% (25 of 114) had HI and EIA antibody titers to JCV and BKV which were identical or closely related. This is not the scenario one would expect for cross-reactive epitopes shared by the two viruses, but one suggesting that these samples were from individuals who had experienced infections by both viruses. Adsorption with concentrated JCV or BKV antigen of sera with high antibody titers to both JCV and BKV and testing by JCV and BKV EIA gave results which support this conclusion. Although 52.6% (51 of 97) of the samples from the Japanese population tested had very high antibody titers (>/=40,960) to either JCV or BKV, none of the samples were found by a dot blot immunoassay to have antibodies which cross-reacted with simian virus 40. The results from this study, in agreement with those of others, suggest that humans infected by JCV or BKV produce antibodies to species-specific epitopes on their VP1 capsid protein, which is associated with hemagglutination and cellular binding. (+info)

Polyomaviruria in renal transplant patients is not correlated to the cold ischemia period or to rejection episodes. (7/481)

Polyomaviruria was observed in one-third of all renal transplant patients, irrespective of whether their renal grafts came from a living or cadaver donor, and was not correlated to graft rejection episodes. This suggests that the renal graft ischemia period is not the major cause of polyomavirus reactivation and that reactivation of polyomavirus is not a dominant cause of graft rejection. (+info)

Documenting the epidemiologic patterns of polyomaviruses in human populations by studying their presence in urban sewage. (8/481)

This is the first description, to our knowledge, of the distribution of human polyomavirus and simian virus 40 (SV40) in urban sewage. Using a nested-PCR procedure, we report the detection of human polyomaviruses JC virus (JCV) and BK virus (BKV) but not SV40 in a high percentage of urban sewage samples obtained from widely divergent geographical areas in Europe and Africa. For a total of 28 samples analyzed, JCV was detected in 26, BKV was detected in 22, and none was positive for SV40. All geographical areas showed a high prevalence of these viruses with mean estimated values of JC viral particles per ml on the order of 10(3) in Barcelona (Spain) and Nancy (France) and 10(2) in Pretoria (South Africa) and Umea (Sweden) and mean values of BK viral particles on the order of 10(2) in Pretoria and Barcelona and 10(1) in Nancy and Umea. This compares with estimated mean values of 10(2) to 10(3) for human adenovirus that was evaluated as a control. Nucleotide sequence analysis of the amplified DNA from some of the samples is also presented and represents the sequence of the most abundant JC and BK viral strains in these samples. The nucleotide sequence of the JCV detected was also analyzed in a phylogenetic study and for genomic characterization in the regulatory region. This study has shown that human polyomaviruses are spread in high concentrations in the sewage of different geographical areas and are present in contaminated environments. The frequency and concentration of JCV detected in the environment and the absence of described animal hosts suggest that JCV may be useful as a marker for fecal pollution of anthropogenic origin. The results also support the idea previously described that the strains of JCV are closely related to the ethnic origin of the population studied. The procedure applied should also be useful in future studies of population patterns of viral excretion and as a tool in epidemiological studies for the detection of changes in the prevalence of specific viral pathogens. (+info)

BK virus infection BK virus Black piedra Piedraia hortae Blastocystosis Blastocystis species ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... Human parainfluenza virus infection Human parainfluenza viruses (HPIV) Hymenolepiasis Hymenolepis nana and Hymenolepis diminuta ...

https://en.wikipedia.org/wiki/List_of_infectious_diseases

BK; Strong, JE; Grolla, A; Wolz, A; Kargbo, B; Kargbo, DK; Formenty, P; Sanders, DA; Kobinger, GP (19 February 2015). " ... The four are Bundibugyo virus (BDBV), Sudan virus (SUDV), Taï Forest virus (TAFV) and one simply called Ebola virus (EBOV, ... The virus responsible for the initial outbreak, first thought to be Marburg virus, was later identified as a new type of virus ... Main articles: Ebola virus cases in the United States, Ebola virus disease in Spain, and Ebola virus disease in the United ...

https://en.wikipedia.org/wiki/Ebola_hemorrhagic_fever

Human immunodeficiency virus, parvovirus B19 and BK virus are known to induce these antibodies. There is little evidence ... Reploeg MD, Storch GA, Clifford DB (July 2001). "Bk virus: a clinical review". Clin. Infect. Dis. 33 (2): 191-202. doi:10.1086/ ... Epstein-Barr virus is also known to induce dsDNA antibodies, as seen after immunisation of animals with EBNA-1 epitopes. Anti- ... These motifs can be key features within the pathogenesis of particular diseases, for example Human Papilloma Virus. Kavanaugh A ...

https://en.wikipedia.org/wiki/Anti-dsDNA_antibodies

... most notably BK virus, JC virus, and SV40. It is essential for proliferation in the viruses that express it and is thought to ... Most of these viruses are very common and typically asymptomatic in most human populations studied. BK virus is associated with ... Kuppachi S, Kaur D, Holanda DG, Thomas CP (April 2016). "BK polyoma virus infection and renal disease in non-renal solid organ ... Kelley WL, Georgopoulos C (April 1997). "The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can ...

https://en.wikipedia.org/wiki/Polyomaviridae

BK virus Epstein-Barr virus infection Glomerulosclerosis--WebMD. ...

https://en.wikipedia.org/wiki/Glomerulosclerosis

2018-10-11). "Allogeneic BK Virus-Specific T Cells for Progressive Multifocal Leukoencephalopathy". New England Journal of ... It is caused by the JC virus, which is normally present and kept under control by the immune system. The JC virus is harmless ... The virus causes disease only when the immune system has been severely weakened.[citation needed] PML is most common in people ... A number of drugs work against JC virus in cell culture, but no proven, effective therapy is known in humans. For example, 1-O- ...

https://en.wikipedia.org/wiki/Progressive_multifocal_leukoencephalopathy

Purighalla, R; Shapiro, R; McCauley, J; Randhawa, P (1995). "BK virus infection in a kidney allograft diagnosed by needle ... Van Aalderen, MC; Heutinck, KM; Huisman, C; Ten Berge, IJ (2012). "BK virus infection in transplant recipients: Clinical ... Moriyama, Takahito; Sorokin, Andrey (2008). "Repression of BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells ... Several viruses mediated the emergence of decoy cells, amongst which cytomegalovirus and polyomavirus. Decoy cells are virus ...

https://en.wikipedia.org/wiki/Decoy_cells

... shows anti-BK virus activity in a subgroup of transplant recipients. Cidofovir is being investigated as a ... "Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy". Pediatr Transplant. 10 (1 ... It has inhibitory effects on varicella-zoster virus replication in vitro although no clinical trials have been done to date, ... Magee, WC; Hostetler, KY; Evans, DH (August 2005). "Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir ...

https://en.wikipedia.org/wiki/Cidofovir

Updated: 5 December 2008 Chong S, Antoni M, Macdonald A, Reeves M, Harber M, Magee CN (July 2019). "BK virus: Current ... BK virus is now being increasingly recognised as a transplant risk factor. Infection is the cause of death in about one third ...

https://en.wikipedia.org/wiki/Kidney_transplantation

Throughout his career, Major has conducted research on viruses including BK virus, adenoviruses, JC virus, simian virus 40 ( ... Olive, DM; Lampert, M; Major, EO (1980). "Comparison of wild-type BK virus DNA and BK virion DNA rescued from virus-transformed ... Major, E. O.; Di Mayorca, G. (1973). "Malignant Transformation of BHK21 Clone 13 Cells by BK Virus-A Human Papovavirus". ... where he researched papovaviruses such as BK virus with Giampiero Di Mayorca. (The papovaviruses have since been split into two ...

https://en.wikipedia.org/wiki/Eugene_O._Major

BK virus or Simian virus. The Ebola virus may also be found in urine from an infected person. The exact survival time of this ... Vanchiere, John A. (12 January 2005). "Detection of BK virus and simian virus 40 in the urine of healthy children". Journal of ... "Ebola (Ebola Virus Disease)Transmission, Q&As on Transmission". CDC (Centres for Disease Control and Prevention). 20 November ... particular virus in human urine outside of the human body is unclear but probably "up to several days" like with other body ...

https://en.wikipedia.org/wiki/Urine-diverting_dry_toilet

Another virus, BK polyomavirus has been detected in the same tissues, but with lesser extent. According to the 2006 WHO ... Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in ... Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in ...

https://en.wikipedia.org/wiki/Products_of_conception

It furthermore enables detection for CMV-, EBV-, influenza-, and BK virus specific CD8+ T cells. Dextramer CMV kit - These MHC ... Virus Dextramer collection 1 - provides reagents for detection, quantification and isolation of virus specific T cells. ...

https://en.wikipedia.org/wiki/Immudex

Teriflunomide also has antiviral effects against numerous viruses including CMV, HSV1 and the BK virus, which it achieves by ... Polyoma BK virus nephropathy Kimura's disease Systemic lupus erythematosus Felty's syndrome Takayasu arteritis Granulomatosis ... Blanckaert K, De Vriese AS (December 2006). "Current recommendations for diagnosis and management of polyoma BK virus ...

https://en.wikipedia.org/wiki/Leflunomide

... including two human viruses - BK virus and JC virus - and the simian virus SV40; the BK, JC, and SV40 examples are by far the ... BK virus and JC virus, as well as the simian polyomavirus SV40. Agnoprotein is typically quite short: examples from BK virus, ... Among sequenced BK virus genomes, agnoprotein is the most variable viral protein in amino acid sequence. Differences in tissue ... Its functions are poorly characterized even in well-studied viruses. Null mutant viruses without agnoprotein are generally ...

https://en.wikipedia.org/wiki/Agnoprotein

BK virus is now being increasingly recognised. Infection is the cause of death in about one third of people with renal ...

https://en.m.wikipedia.org/wiki/Kidney_transplantation

BK virus, poxviruses, and herpes simplex viruses. It appears to have potential for the treatment of Ebola virus disease, which ... Brincidofovir was administered to the first patient diagnosed in the Ebola virus disease outbreak in the US in 2014. The ... Brincidofovir is one of several experimental drugs administered to a small number of patients to treat Ebola virus disease ... "Ethical considerations for use of unregistered interventions for Ebola virus disease". Retrieved 8 October 2014. Kern ER, ...

https://en.wikipedia.org/wiki/Brincidofovir

"Allogeneic BK Virus-Specific T Cells for Progressive Multifocal Leukoencephalopathy". New England Journal of Medicine. 379 (15 ... JC virus infectionEdit. The cause of PML is a type of polyomavirus called the JC virus (JCV), after the initials of the person ... It is caused by the JC virus, which is normally present and kept under control by the immune system. The JC virus is harmless ... A number of drugs work against JC virus in cell culture, but no proven, effective therapy is known in humans.[21] For example, ...

https://en.m.wikipedia.org/wiki/Progressive_multifocal_leukoencephalopathy

Immunosuppression BK virus Behcet's Disease Discovery and development of mTOR inhibitors Treatment methods for preventing organ ...

https://en.wikipedia.org/wiki/Immunosuppressive_drug

Ionfhabhtú BK virus. BK virus. Black piedra. Piedraia hortae. Ionfhabhtú Blastocystis hominis. Blastocystis hominis. ... Ionfhabhtú Human parainfluenza virus. Human parainfluenza viruses (HPIV). Hymenolepiasis. Hymenolepis nana and Hymenolepis ... Colorado tick fever virus (CTFV). Common cold (Acute viral rhinopharyngitis; Acute coryza). usually rhinoviruses and ... Dengue viruses (DEN-1, DEN-2, DEN-3 and DEN-4) - Flaviviruses. ... Hepatitis E Virus. Herpes simplex. Herpes simplex virus 1 and 2 ...

https://ga.wikipedia.org/wiki/Liosta_de_ghalair_thógálacha

"BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors". Polyomaviruses and Human ... The virus causing this illness was isolated in 1937. The rash typical of Lyme borreliosis was identified the early 1900s. ... Natelson, BH; Ye, N; Moul, DE; Jenkins, FJ; Oren, DA; Tapp, WN; Cheng, YC (1994). "High titers of anti-Epstein-Barr virus DNA ... Atkinson, RL (2007). "Viruses as an etiology of obesity". Mayo Clinic Proceedings. 82 (10): 1192-8. doi:10.4065/82.10.1192. ...

https://en.wikipedia.org/wiki/Infections_associated_with_diseases

... and may be more susceptible to certain viruses including Epstein-Barr virus, BK virus, and molluscum contagiosum. BENTA disease ... Some patients may not mount protective antibody titers to other vaccines, such as measles and varicella zoster virus. T cell ...

https://en.wikipedia.org/wiki/BENTA_disease

... most relevantly with the nephropathy associated in kidney transplant recipients with the polyomavirus BK virus. Antiviral drugs ... used electron microscopy to identify the presence of virus particles in affected cells consistent with what were at the time ... There is evidence that exposure to the virus is common among healthy adults; estimates of seroprevalence (that is, prevalence ... but viral DNA is rarely detectable there in asymptomatic individuals even if they possess antibodies to the virus indicating ...

https://en.wikipedia.org/wiki/Trichodysplasia_spinulosa

Immunosuppressive drug Discovery and development of mTOR inhibitors BK virus Interleukin-2 immunotherapy B cell deficiency T ... and viruses Immunodeficiency is also a potential adverse effect of many immunosuppressant drugs, in this sense, the scope of ... and certain chronic infections such as human immunodeficiency virus (HIV). The unwanted effect in non-deliberate ...

https://en.wikipedia.org/wiki/Immunosuppression

... though it can result from BK virus as well. A chemical hemorrhagic cystitis can develop when vaginal products are inadvertently ... system are at risk for hemorrhagic cystitis due to either the direct effects of chemotherapy or activation of dormant viruses ...

https://en.wikipedia.org/wiki/Hemorrhagic_cystitis

Biswal BK, Wang M, Cherney MM, et al. (August 2006). "Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis ... The hepatitis C virus (HCV)[2] is a small (55-65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ...

https://en.wikipedia.org/wiki/Hepatitis_C_virus

Blevins, T.; Rajeswaran, R.; Aregger, M.; Borah, BK.; Schepetilnikov, M.; Baerlocher, L.; Farinelli, L.; Meins, F.; et al. (Jul ... 1999). "Virus taxonomy--1999. The universal system of virus taxonomy, updated to include the new proposals ratified by the ... The complete molecular characterization and study of this virus was not carried further. Cauliflower mosaic virus possesses a ... The virus is acquired from an infected host during feeding by the aphid vector. To occur, a transmissible complex is composed ...

https://en.wikipedia.org/wiki/Cauliflower_mosaic_virus

... bk virus MeSH B04.909.204.210.620.615.400 - jc virus MeSH B04.909.204.210.620.615.700 - simian virus 40 MeSH B04.909.204.210. ... bk virus MeSH B04.909.574.204.670.615.400 - jc virus MeSH B04.909.574.204.670.615.700 - simian virus 40 MeSH B04.909.574.204. ... bk virus MeSH B04.909.675.615.400 - jc virus MeSH B04.909.675.615.700 - simian virus 40 MeSH B04.909.777.080 - arenaviridae ... bk virus MeSH B04.280.640.615.400 - jc virus MeSH B04.280.640.615.700 - simian virus 40 MeSH B04.280.650.160 - chordopoxvirinae ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B04)

BK virus and JC virus, among others. Founded in 1983, IBT was the first laboratory to offer a test to definitively diagnose ...

https://en.wikipedia.org/wiki/Viracor-IBT_Laboratories

doi:10.1021/bk-1995-0605.ch012. ISBN 0-8412-3320-9.. *^ Chan, Y.; Yang, A.; Chen, J.; Yeh, K.; Chan, M. (2010). "Heterologous ... anthrax and respiratory syncytial virus.[41] Korean scientists are looking at using the tomato to express a vaccine against ...

https://en.wikipedia.org/wiki/Fish_tomato

Nogometaši Lyngbyja BK. *Nogometaši ADO Den Haaga. *Nogometaši ND Mure 05. *Murskosobočani ...

https://sl.wikipedia.org/wiki/Mitja_Mörec

... can be infected by double-stranded DNA viruses that are unrelated to any other form of virus and have a variety of ... Lange, M; Westermann, P; Ahring, BK (2005). "Archaea in protozoa and metazoa". Applied Microbiology and Biotechnology. 66 (5): ... the latter virus has the largest currently reported ssDNA genome. Defenses against these viruses may involve RNA interference ... One group is exemplified by the Halorubrum pleomorphic virus 1 ("Pleolipoviridae") infecting halophilic archaea[137] and the ...

https://en.m.wikipedia.org/wiki/Archaea

DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... The JC virus or John Cunningham virus is a type of human polyomavirus (formerly known as papovavirus). It was identified by ... DNA virus. HBV Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. ...

https://en.wikipedia.org/wiki/Jc_virus

Smith BK, Timby NE (2005). Essentials of nursing : care of adults and children. Lippincott Williams & Wilkins. p. 338. ISBN 978 ... viruses in 23%, and both in 25%.[65] Environmental pollutants include both poor indoor and outdoor air quality.[63] Exposure to ...

https://en.wikipedia.org/wiki/COPD

As arqueas poden ser infectadas por virus de ADN bicatenario que non están relacionados con ningún outro tipo de virus e teñen ... Lange M; Westermann P; Ahring BK; Lange, M; Westermann, P; Ahring B.K. (2005). "Archaea in protozoa and metazoa". Applied ... Pietilä MK, Roine E, Paulin L, Kalkkinen N, Bamford DH (2009). "An ssDNA virus infecting archaea; A new lineage of viruses with ... Ligamenvirales, virus que infectan arqueas. Ligazóns externas[editar , editar a fonte]. *. "Introduction to the Archaea". UCMP ...

https://gl.wikipedia.org/wiki/Archaea

... certain Epstein-Barr virus gene products bearing this sequence can stall the proteasome, helping the virus propagate by ... Witt S, Kwon YD, Sharon M, Felderer K, Beuttler M, Robinson CV, Baumeister W, Jap BK (July 2006). "Proteasome assembly triggers ... Zhang M, Coffino P (March 2004). "Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome ... the 11S may play a role in degradation of foreign peptides such as those produced after infection by a virus.[16] ...

https://en.m.wikipedia.org/wiki/Proteasome

Vesicular stomatitis virus is believed to be taken up by the autophagosome from the cytosol and translocated to the endosomes ... Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J ( ... A subset of viruses and bacteria subvert the autophagic pathway to promote their own replication.[63] Galectin-8 has recently ... "Subversion of cellular autophagosomal machinery by RNA viruses". PLoS Biol. 3 (5): e156. doi:10.1371/journal.pbio.0030156. PMC ...

https://en.wikipedia.org/wiki/Autophagy_

Pedersen BK (December 2009). "The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk". J ... response to virus. • positive regulation of osteoclast differentiation. • negative regulation of cytokine secretion involved in ... Starkie R, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK (2003). "Exercise and IL-6 infusion inhibit endotoxin-induced TNF- ...

https://en.wikipedia.org/wiki/TNF-alpha

It is a member of the Semliki Forest virus complex and is closely related to Ross River virus, O'nyong'nyong virus, and Semliki ... Mahendradas P, Ranganna SK, Shetty R, Balu R, Narayana KM, Babu RB, Shetty BK (February 2008). "Ocular manifestations ... and false positives can occur with infection due to other related viruses, such as o'nyong'nyong virus and Semliki Forest virus ... Chikungunya virus is passed to humans when a bite from an infected mosquito breaks the skin and introduces the virus into the ...

https://en.wikipedia.org/wiki/Chikungunya_vaccine

ViriUredi. *. Bhargava, Alok; Guthrie, J. (2002). "Unhealthy eating habits, physical exercise and macronutrient intakes are ... Weng HH, Bastian LA, Taylor DH, Moser BK, Ostbye T (2004). "Number of children associated with obesity in middle-aged women and ... da so glavni viri predelane hrane poceni v primerjavi s sadjem in zelenjavo.[85] Zakonski predpisi o obveznem navajanju kalorij ... Primarni viri teh dodatnih ogljikovih hidratov so sladkane pijače, ki pri mladih odraslih Američanih predstavljajo 25 odstotkov ...

https://sl.m.wikipedia.org/wiki/Debelost

Walian P, Cross TA, Jap BK (2004). "Structural genomics of membrane proteins". Genome Biology. 5 (4): 215. doi:10.1186/gb-2004- ... Eukaryotes have 15,000, bacteria have 3,200, archaea have 2,400, and viruses have 42 proteins on average coded in their ... including assembled viruses;[58] a variant known as electron crystallography can also produce high-resolution information in ...

https://en.m.wikipedia.org/wiki/Protein_synthesis

Pedersen BK (January 2011). "Muscles and their myokines". The Journal of Experimental Biology. 214 (Pt 2): 337-46. doi:10.1242/ ... Epstein-Barr virusEdit. In humans with history of acute infectious mononucleosis (the syndrome associated with primary Epstein- ... regulation of defense response to virus by host. • positive regulation of inflammatory response. • response to nutrient levels ... Xu X, Sun Q, Yu X, Zhao L (April 2017). "Rescue of nonlytic Newcastle Disease Virus (NDV) expressing IL-15 for cancer ...

https://en.m.wikipedia.org/wiki/Interleukin_15

Law BK, Chytil A, Dumont N, Hamilton EG, Waltner-Law ME, Aakre ME, Covington C, Moses HL (December 2002). "Rapamycin ... significantly limiting production of new viruses.[36] ...

https://en.wikipedia.org/wiki/P21

Gene therapy typically involves the use of a non-infectious virus (i.e., a viral vector such as the adeno-associated virus) to ... Harvey BK, Wang Y, Hoffer BJ (2008). "Transgenic rodent models of Parkinson's disease". Acta Neurochirurgica. Supplement. Acta ...

https://en.wikipedia.org/?title=Parkinson's_disease

Another virus, BK polyomavirus has been detected in the same tissues, but with lesser extent.[8] ... "Footprints of BK and JC polyomaviruses in specimens from females affected by spontaneous abortion". Hum Reprod. 34 (3): 433- ... "Footprints of BK and JC polyomaviruses in specimens from females affected by spontaneous abortion". Hum Reprod. 34 (3): 433- ...

https://en.m.wikipedia.org/wiki/Chorion

Kim SG, Kim BK, Kim K, Fang S (December 2016). "Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for ... Ivermectin is also being studied as a potential antiviral agent against the viruses chikungunya and yellow fever.[66] ...

https://en.wikipedia.org/wiki/Ivermectin

Recent papers have proposed the use of viruses to treat infections caused by protozoa.[65][66] ... Sullivan BK, Neuhauser S (April 2018). "Not in your usual Top 10: protists that infect plants and algae". Molecular Plant ...

https://en.m.wikipedia.org/wiki/Protists

In vitro virus high-throughput sequencing[edit]. A method has been developed to analyze full sets of protein interactions using ... Peterson BK, Weber JN, Kay EH, Fisher HS, Hoekstra HE (2012). "Double digest RADseq: an inexpensive method for de novo SNP ... "The Next Frontier: Human Viruses" , whatisbiotechnology.org, Retrieved May 3, 2017. *^ Beck S, Pohl FM (1984). "DNA sequencing ... In some viruses (specifically, bacteriophage), cytosine may be replaced by hydroxy methyl or hydroxy methyl glucose cytosine.[5 ...

https://en.wikipedia.org/wiki/Sequencing_technology

DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... DNA virus. HBV Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. ... RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/lymphoma. ...

https://en.wikipedia.org/wiki/CNS_lymphoma

Fribley AM، Evenchik B، Zeng Q، Park BK، Guan JY، Zhang H، Hale TJ، Soengas MS، Kaufman RJ، Wang CY (Oct 2006). "Proteasome ... which can be overcome by helper adenovirus type 5 virus-associated RNA". Journal of Virology. 81 (21): 11908-16. PMC 2168773. ... "Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, ...

https://ar.wikipedia.org/wiki/EIF2A

Tyler KL (June 2004). "Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including ...

https://ko.wikipedia.org/wiki/바이러스성_수막염

Yao Y, Zhao Y, Xu H, Smith LP, Lawrie CH, Watson M, Nair V (April 2008). "MicroRNA profile of Marek's disease virus-transformed ... Lui WO, Pourmand N, Patterson BK, Fire A (July 2007). "Patterns of known and novel small RNAs in human cervical cancer". Cancer ... T-cell line MSB-1: predominance of virus-encoded microRNAs". Journal of Virology. 82 (8): 4007-15. doi:10.1128/JVI.02659-07. ...

https://en.wikipedia.org/wiki/Mir-181_microRNA_precursor

Dog har nye genetiske undersøgelser ændret denne opfattelse, da det har vist sig at virus nedstammer fra en fælles stamform med ... Bk. Cf. Es. Fm. Md. No De fire elementære biokemiske grundstoffer Andre vigtige biokemiske grundstoffer ... Viruses ARE alive, and they're older than modern cells, new study suggests. Science Alert 2015 ... Denne definition får straks frøet og bakterien fra ovenstående eksempel til at "passe bedre ind". Virus bliver typisk ikke ...

https://da.wikipedia.org/wiki/Liv

Klein BK, Feng Y, McWherter CA, et al., The receptor binding site of human interleukin-3 defined by mutagenesis and molecular ... Than S, Oyaizu N, Pahwa RN, et al., Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine ... Feng Y, Klein BK, McWherter CA, Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. ...

https://it.wikipedia.org/wiki/Interleuchina_3

Kellett HA, Sawers JS, Boulton FE, Cholerton S, Park BK, Toft AD (January 1986). "Problems of anticoagulation with warfarin in ... "Viruses. 6 (5): 1911-28. doi:10.3390/v6051911. PMC 4036541. PMID 24784570.. ...

https://en.m.wikipedia.org/wiki/Warfarin

可能感染白蟻的病毒包括 Entomopoxvirinae（英语：Entomopoxvirinae）和核多角病毒[139][140]（Nuclear Polyhedrosis Virus（英语：Nuclear Polyhedrosis Virus））。 ... Neoh, K.-B.; Yeap, B.-K.; Tsunoda, K.; Yoshimura, T.; Lee, C.Y.; Korb, J. Do termites avoid carcasses? behavioral responses ... Al Fazairy, A.A.; Hassan, F.A. Infection of Termites by Spodoptera littoralis Nuclear Polyhedrosis Virus. International Journal ... Chouvenc, T.; Mullins, A.J.; Efstathion, C.A.; Su, N.-Y. Virus-like symptoms in a termite (Isoptera:

https://zh.wikipedia.org/wiki/白蟻

May). „Oncogenic role of JC virus in lung cancer". Journal of Pathology 212 (3), 306-315. o. DOI:10.1002/path.2188. PMID ... Feltételezett patogének: humán papillómavírus,[76] JC vírus,[77] SV40, BK, citomegalovírus.[78] Ezen kórokozók befolyásolhatják ... Leroux, C, Girard N, Cottin V et al.. „Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep". Veterinary ... September). „Detection of oncogenic viruses (SV40, BKV, JCV, HCMV, HPV) and p53 codon 72 polymorphism in lung carcinoma". Lung ...

https://hu.wikipedia.org/wiki/Tüdőrák

The herpes simplex virus-derived AD, VP16 and yeast Gal4 AD have been used with success in yeast[1] whilst a portion of the α- ... Lee JA, Lee SH, Lee C, Chang DJ, Lee Y, Kim H, Cheang YH, Ko HG, Lee YS, Jun H, Bartsch D, Kandel ER, Kaang BK (September 2006 ... Choi JH, Lee JA, Yim SW, Lim CS, Lee CH, Lee YD, Bartsch D, Kandel ER, Kaang BK (2003). "Using an aplysia two-hybrid system to ... "A physical interaction network of dengue virus and human proteins". Molecular & Cellular Proteomics. 10 (12): M111.012187. doi ...

https://en.wikipedia.org/wiki/Two-hybrid_screening

... virus, ex Human Papilloma virus) ஏற்படும் நோய் ஆகும்.உயிரணு பிரிதலை கட்டுப்படுத்தும் (Ex. Retinoblastoma protein) அல்லது புற்று ... English DR, Armstrong BK, Kricker A, Fleming C (May 1997). "Sunlight and cancer". Cancer causes & control : CCC 8 (3): 271-83. ... zur Hausen H (1991). "Viruses in human cancers". Science 254 (5035): 1167-73. doi:10.1126/science.1659743. பப்மெட் 1659743. ... transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus". ...

https://ta.wikipedia.org/wiki/புற்றுநோய்

... Syed Hassan,1 Zaid Alirhayim,1 Syed Ahmed,2 and Syed Amer3 ... Syed Hassan, Zaid Alirhayim, Syed Ahmed, and Syed Amer, "Polyoma BK Virus: An Oncogenic Virus?," Case Reports in Nephrology, ...

https://www.hindawi.com/journals/crin/2013/858139/cta/

BK virus synonyms, BK virus pronunciation, BK virus translation, English dictionary definition of BK virus. n. pl. vi·rus·es 1 ... virus. → فَيْرُوس vir virus Virus ιός virus virus virus virus virus ウイルス 바이러스 virus virus wirus vírus вирус virus เชื้อไวรัส ... virus فيروس، جُرْثومَه вирус vírus virus das Virus virus ιόςvirus viirus ویروس virus virusוירוס छूत के रोग पैदा करने वाले ... virus فيروس في الكومبيوتر комп. вирус vírus virus der Virus virus ιός Η/Υ virus arvutiviirus

https://www.thefreedictionary.com/BK+virus

For quantitative detection of BK virus specific DNA using real-time PCR Show details ... QIAsymphony DSP Virus/Pathogen Kit For automated purification of viral nucleic acids or bacterial/pathogen DNA from 1-96 ...

https://www.qiagen.com/fi/products/molecular-diagnostics/infectious-disease/bk-virus-automated/

The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K. The BK virus is similar to ... The BK virus is a member of the polyomavirus family. Past infection with the BK virus is widespread, but significant ... Overview of the BK virus MicrobiologyBytes: Polyomaviruses Reploeg MD, Storch GA, Clifford DB (July 2001). "Bk virus: a ... BK virus is an abbreviation of the name of the first patient whom the virus was isolated from in 1971 (the patient was then 29 ...

https://en.wikipedia.org/wiki/BK_virus

Care guide for Bk Virus Infection (Inpatient Care). Includes: possible causes, signs and symptoms, standard treatment options ... A BK virus (BKV) infection is a common viral infection that usually does not cause problems. The virus normally remains ... Antiviral medicine may be used to kill the BK virus.. *Antirheumatic drugs may be used to help your immune system and kill the ... A kidney biopsy is a procedure to remove a small amount of tissue from your kidney to see if you are infected with the BK virus ...

https://www.drugs.com/cg/bk-virus-infection-inpatient-care.html

Antibodies to JC and BK viruses among persons with non-Hodgkin lymphoma ... Antibodies to JC and BK viruses among persons with non-Hodgkin lymphoma Cached. * ... title = {Antibodies to JC and BK viruses among persons with non-Hodgkin lymphoma},. year = {}. }. ... Antibodies to JC and BK viruses among persons with non-Hodgkin lymphoma ...

http://citeseer.ist.psu.edu/viewdoc/summary?doi=10.1.1.955.4473

... Luciana Antoniolli, Rafael Borges, and Luciano Z. ...

https://www.hindawi.com/journals/crim/2017/4307468/abs/

Anti-BK Virus Immune Response and Kidney Transplantation (BKv). The recruitment status of this study is unknown. The completion ... BK virus infections are very frequent during months following a kidney transplantation: a viral reactivation is observed for ... Role of Specific Immune Cellular Response in the Control of BK Virus Infection: Prospective Study, Monocentric and Longitudinal ...

https://clinicaltrials.gov/ct2/show/NCT01109186?recr=Open&intr=kidney+transplantation&rank=19

Anti-BK Virus Immune Response and Kidney Transplantation (BKv). The safety and scientific validity of this study is the ... BK virus infections are very frequent during months following a kidney transplantation: a viral reactivation is observed for ... Role of Specific Immune Cellular Response in the Control of BK Virus Infection: Prospective Study, Monocentric and Longitudinal ...

https://clinicaltrials.gov/ct2/show/NCT01109186?recr=Open&intr=kidney+transplantation&rank=15

Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within USA), 301-223-2300 (international) [email protected] ...

https://journals.lww.com/transplantjournal/Citation/1974/01000/SEARCH_FOR_BK_AND_SV40_VIRUS_REACTIVATION_IN_RENAL.22.aspx

While we are ranked among the best childrens hospitals in the country, its our compassionate approach to treatment that makes us truly exceptional. Through a combination of revolutionary treatments and extraordinary patient experiences, our care does more than heal. It brings the entire family together for emotional support and understanding across multiple locations to reach you in the community where you live. Learn more... ...

https://www.akronchildrens.org/lab_tests/BK-Virus-PCR-Quantitative.html

Intravenous immunoglobulin as rescue therapy for BK virus nephropathy. Pediatric Transplantation, 13: 123-129. doi: 10.1111/j. ...

http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3046.2008.00958.x/references

How does BK virus cause disease? * What other clinical manifestations may help me to diagnose and manage BK virus associated ... BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ... In a patient with BK virus associated diseases, what if a rise of BK serology is detected? *. A rise of BK serology is ...

https://www.oncologynurseadvisor.com/infectious-diseases/bk-virus-clinical-condition/article/610719/

b,BK virus has been detected both in blood and urine.,/b, What is BK virus? How can my creatinine level be managed? ... BK virus has been detected both in blood and urine. What is BK virus? How can my creatinine level be managed? ... A:BK virus can infect and result in kidney allograft (transplanted) dysfunction, prevalence rate being around 5% within 10-12 ... After the diagnosis of BK virus disease or the nephropathy in the transplanted kidney, first line of approach is to reduce the ...

https://doctor.ndtv.com/faq/what-does-bk-virus-indicate-41179

How does BK virus cause disease? * What other clinical manifestations may help me to diagnose and manage BK virus associated ... BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ... BK Virus Screening in Transplant Patients May Be Suboptimal. *Active Surveillance for BK Virus May Help Minimize Nephropathy in ...

https://www.renalandurologynews.com/infectious-diseases/bk-virus-clinical-condition/article/610718/

Simian virus 40 (SV-40), JC virus (JCV), and BK virus (BKV). SV-40 naturally infects rhesus monkeys but can infect humans, ... DNA-containing viruses and include 3 closely related viruses of clinical significance: ... Simian virus 40 (SV-40), JC virus (JCV), and BK virus (BKV). SV-40 naturally infects rhesus monkeys but can infect humans, ... To supplement the above data, 30 negative plasma and urine specimens were spiked with BK virus (BKV)-positive control plasmid ...

https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83187

Although polyoma BK virus (BKV)-associated interstitial nephritis has received increasing attention because of its clinical ... Retransplantation after kidney graft loss due to polyoma BK virus nephropathy: successful outcome without original allograft ...

https://www.ncbi.nlm.nih.gov/pubmed/14520634?dopt=Abstract

For BK virus nephropathy, cidofovir, and leflunomide are effective antiviral drugs, with both BK virus and JC virus responding ... BK virus can cause hemorrhagic cystitis in patients with bone marrow transplants (up to 25-60%). BK virus nephropathy is seen ... The main polyomaviruses causing disease in humans are the BK, MK (Merkel cell virus), SV40 (simian vacuolating virus), and JC ( ... John Cunningham and BK)?*What is the role of and impact of viruses - polyomaviruses (John Cunningham and BK) or infections and ...

https://www.clinicaladvisor.com/home/decision-support-in-medicine/hospital-infection-control/viruses-polyomaviruses-john-cunningham-and-bk/

Troj/Tesla-BK. Category: Viruses and Spyware. Protection available since:. 02 Sep 2020 22:18:03 (GMT). ... Troj/Tesla-BK exhibits the following characteristics: File Information. Size. 494K. SHA-1. ... Download our free Virus Removal Tool - Find and remove threats your antivirus missed ...

https://www.sophos.com/en-us/threat-center/threat-analyses/viruses-and-spyware/Troj~Tesla-BK/detailed-analysis.aspx

BK viremia was defined as a BK viral load ,100 copies/mL in blood. Among 168 patients assessed for BK virus status, 30 patients ... Every patient with BK viremia and Alport syndrome developed BKVN, while only 11.1% of patients with BK viremia progressed to ... The study investigated the incidence, risk factors, and clinical outcomes of BK viremia and BKVN in a Korean population of ... BKVN was defined as biopsy-proven BKVN or plasma BK viral loads ,10,000 copies/mL for ,3 weeks. ...

https://www.mdpi.com/2077-0383/8/4/491

BK virus (BKV) is a member of the Polyomaviridae family, which also includes the well-studied simian virus 40 (SV40) and human ... Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV). Adv. Exp. Med. Biol. 577:19-45. ... Early Events during BK Virus Entry and Disassembly. Mengxi Jiang, Johanna R. Abend, Billy Tsai, Michael J. Imperiale ... Early Events during BK Virus Entry and Disassembly Message Subject (Your Name) has forwarded a page to you from Journal of ...

https://jvi.asm.org/content/83/3/1350?ijkey=714a0f9d8f984f744336fd192a5bd32723c4efc4&keytype2=tf_ipsecsha

... The BK virus is a virus that mainly infects the kidneys and urinary tract. Most people get infected with the BK virus ... Infection with the BK virus rarely causes symptoms, except in people who have a weakened immune system. Most of the problems ... from the BK virus are seen in people who have had an organ transplant. People who have transplanted organs must take medicines ...

https://www.lancastergeneralhealth.org/healthwise-library/condition-categories/blood-and-lymph-system?lang=en-us&DocumentId=abn2468

BK Virus Nephropathy and Kidney Transplantation Message Subject (Your Name) has sent you a message from American Society of ... a BKV, BK virus; NPV, negative predictive value; PPV, positive predictive value; RT-PCR, reverse transcription-PCR. ... BK Virus Nephropathy and Kidney Transplantation. Daniel L. Bohl and Daniel C. Brennan ... Type and prevalence of BK virus (BKV) infections in kidney transplant recipients. ...

https://cjasn.asnjournals.org/content/2/Supplement_1/S36/tab-figures-data

I have 3 different viruses post transplant - BK virus, EB virus and CM virus and they knew I had at least one of these at low ( ... BK virus. by olive » Thu May 19, 2016 5:39 pm Hi everyone, im new to this group can anyone tell me about the bk virus as ive ... How are you all going witb the bk virus? He has me to ask you all....when he was first told he had BK he had a sore throat and ... BK virus. This is the forum for the Kidney Patient Guide. We welcome feedback about the site and any information that may be of ...

http://www.kidneypatientguide.org.uk/forum/viewtopic.php?p=72776

Bk virus. About 357 results for "bk virus" (0.00 seconds) - 57 Topics - 300 Posts ... West Nile Virus, Herpes Zoster Oticus, Fifth Disease, Cytomegalovirus Infections, Respiratory Syncytial Virus Infections ... They told him he was coming down with a virus. Well we saw a doctor - 90% more... Tynkerbelle- over a year ago - 2 Replies - in ... Ruth 60 I have had PMR and TA since 2009, probably triggered by a swine flu virus and both my late mother and her father had it ...

https://www.medications.com/search?q=bk%20virus

BK virus is a human polyomavirus that resides in the kidneys of up to 90% of healthy individuals. Reactivation of the BK virus ... How does BK virus cause disease?*What other clinical manifestations may help me to diagnose and manage BK virus associated ... How does BK virus cause disease?. * BK virus primary infection occurs in childhood. Primary infection is asymptomatic. ... BK virus PCR is checked in the blood every 4 weeks until BK virus is completely suppressed. Studies have shown decreased ...

https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/infectious-diseases/bk-virus-clinical-condition/

Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of ... With the modified therapy, 12 patients cleared the virus at a mean of 109 days. One graft was lost due to refractory rejection ...

https://pubmed.ncbi.nlm.nih.gov/19715969/?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

... Hellström, Vivan Uppsala University, ... Five of eleven cancers of the urinary tract were BK-virus positive. Allograft immune response against these tumours offer new ...

http://uu.diva-portal.org/smash/record.jsf?pid=diva2:916458

Shah K. V. Polyoma viruses (JC virus, BK virus, and simain virus 40) and human cancer Goedert J. J. eds. . Infectious Causes of ... Serum Antibodies to JC Virus, BK Virus, Simian Virus 40, and the Risk of Incident Adult Astrocytic Brain Tumors. Dana E. M. ... Genomic sequences of the human polyomaviruses, JC virus (JCV) and BK virus (BKV), and simian virus 40 (SV40) have been reported ... Serum Antibodies to JC Virus, BK Virus, Simian Virus 40, and the Risk of Incident Adult Astrocytic Brain Tumors ...

http://cebp.aacrjournals.org/content/12/5/460.full

BK virus (BKV) is a ubiquitous virus and its primary infection is generally asymptomatic. It occurs in childhood [2] and, as ... Reploeg MD, Storch GA, Clifford DB (2001) BK virus: a clinical review. Clin Infect Dis 33:191-202CrossRefPubMedGoogle Scholar ... Gupta N, Lawrence RM, Nguyen C, Modica RF (2015) Review article: BK virus in systemic lupus erythematosus. Pediatr Rheumatol 13 ... Hix JK et al (2004) Delirium in a renal transplant recipient associated with BK virus in the cerebrospinal fluid. ...

https://rd.springer.com/article/10.1007%2Fs10072-018-3413-3

The BK virus is a member of the polyomavirus family. (wikipedia.org)
BK virus (BKV) is a nonenveloped, ubiquitous human polyomavirus that establishes a persistent infection in healthy individuals. (asm.org)
Genomic sequences of the human polyomaviruses, JC virus (JCV) and BK virus (BKV), and simian virus 40 (SV40) have been reported from several types of human brain tumors, but there have been no population-based seroepidemiologic studies to evaluate the association between polyomavirus infection and brain tumors. (aacrjournals.org)
The polyomavirus family includes two human viruses, JCV 3 and BKV. (aacrjournals.org)
BK polyomavirus (BKV)-associated nephropathy is a threat to kidney allograft survival affecting up to 15% of renal transplant patients. (ovid.com)
Schematic representation of the BK polyomavirus (BKPyV) genome. (jle.com)
BK polyomavirus (BKPyV) replication cycle. (jle.com)
Flow diagram for screening and management of BK polyomavirus (BKPyV) infections in kidney transplantation (from [55] ). (jle.com)
The BK polyomavirus (BKPyV) is one of the main human polyomaviruses. (jle.com)
Background: BK virus, genus polyomavirus, is known as an important cause of nephropathy (BKVN) in renal transplant patients. (eur.nl)
Human polyomavirus BK (BKV) asymptomatically infects 80~90% of people during early childhood, and establishes a life-long persistent infection without causing overt clinical symptoms. (umsystem.edu)
Polyomavirus hominis 1 (genus Polyomaviridae ), the BK virus, is a non-encapsulated DNA virus that is highly prevalent in healthy adults with up to 90% seropositivity. (haematologica.org)
In this brief commentary, we wish to point out recent advancements done on the role of the human polyomavirus BK (BKPyV) in the development of PCa by harnessing both humoral and cellular immune responses. (uzh.ch)
BK virus is a polyomavirus that infects the majority of the population and subsequently remains dormant in the kidney without consequence. (asnjournals.org)
The most divergent BKV CAP clones differed at 0·55 % of sites, implying a rate of nucleotide substitution of approximately 5×10 −5 substitutions per site per year, which is two orders of magnitude faster than estimated for the other human polyomavirus, JC virus. (microbiologyresearch.org)
BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies. (semanticscholar.org)
The human polyomavirus BK (BKPyV): virological background and clinical implications. (semanticscholar.org)
Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. (semanticscholar.org)
BK polyomavirus-associated nephropathy is an important cause of post-transplantation renal failure. (altmetric.com)
We present two cases of BK polyomavirus-associated nephropathy who were submitted to contrasting strategies of clinical follow-up to BK polyomavirus reactivation, but progressed to a similar final outcome. (altmetric.com)
stage B BK polyomavirus-associated nephropathy was diagnosed by biopsy at 14 months post-transplant. (altmetric.com)
Despite clinical treatment (dosage decrease and immunosuppressive drug change), he progressed to stage C BK polyomavirus-associated nephropathy and loss of graft function 30 months post-transplant. (altmetric.com)
Even with decreasing immunosuppression, he developed BK polyomavirus-associated nephropathy 1-year post-transplant. (altmetric.com)
Decoy cell shedding may be related to BK polyomavirus-associated nephropathy when extensive and persistent. (altmetric.com)
The presence of associated tacrolimus nephrotoxicity may be a confounding factor for the clinical diagnosis of BK polyomavirus-associated nephropathy. (altmetric.com)
BK virus is a polyomavirus that occurs worldwide with a prevalence of 60 to 80% in the general population[ 5 ]. (biomedcentral.com)
BK polyomavirus in solid organ transplantation. (jamanetwork.com)
Polyomavirus (BK) in pediatric renal transplants: evaluation of viremic patients with and without BK associated nephritis. (jamanetwork.com)
BK Polyoma(SV-40) is vital to evaluate renal allograft biopsies as a marker of Polyomavirus infection. (apollodiagnostics.in)
Urine samples and blood samples are assessed to determine the presence of BK virus (BK polyomavirus). (apollodiagnostics.in)
While the development of potent immunosuppressant medications has reduced the incidence of acute rejection to less than 10 percent, it can also lead to the reactivation of the BK virus, a polyomavirus with a prevalence rate of 60 to 80 percent in the general population. (healthmanagement.org)
BK polyomavirus (BKV) establishes persistent, low-level, and asymptomatic infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and other pathologies in some individuals. (ucd.ie)

Past infection with the BK virus is widespread, but significant consequences of infection are uncommon, with the exception of the immunocompromised and the immunosuppressed. (wikipedia.org)
A BK virus (BKV) infection is a common viral infection that usually does not cause problems. (drugs.com)
A BK infection may cause your kidneys or other organs to fail, and may become life-threatening. (drugs.com)
After asymptomatic BK virus primary infection in childhood of up to 90% of the general population, BK virus establishes lifelong residence in kidney epithelial cells. (oncologynurseadvisor.com)
A retrospective review was performed to assess the risk factors and outcomes of BK virus infection and nephropathy (BKVN), an early complication in pediatric kidney allograft recipients. (mdpi.com)
Primary infection with BKV is followed by dissemination to the kidney and urinary tract, in particular to kidney tubule epithelial cells and urinary tract epithelial cells, where the virus establishes a lifelong persistent infection ( 9 ). (asm.org)
Infection with the BK virus rarely causes symptoms, except in people who have a weakened immune system. (lancastergeneralhealth.org)
In these people, a BK virus infection can damage the kidneys. (lancastergeneralhealth.org)
BK virus infection is considered to be contagious between people. (kidneypatientguide.org.uk)
BK virus (BKV) is a ubiquitous virus and its primary infection is generally asymptomatic. (springer.com)
Does this patient have BK virus infection? (renalandurologynews.com)
How should patients with BK virus infection be managed? (renalandurologynews.com)
BKV infection of primary human TEC did not induce an antiviral response, whereas infection with influenza A virus, herpes simplex virus 1, or cytomegalovirus induced a strong antiviral response measured by upregulation of interferon-stimulated genes, such as CXCL10 and DAI. (ovid.com)
Much progress has been made in recent years in the description of virus-cell interactions, but many aspects of viral physiopathology remain mysterious, principally due to the asymptomatic nature of infection in immunocompetent individuals and the lack of an animal model. (jle.com)
Background Hemorrhagic cystitis is a common cause of morbidity after allogeneic stem cell transplantation, frequently associated with BK virus infection. (haematologica.org)
BK virus infection has been connected with development of hemorrhagic cystitis after allogeneic transplant, but most studies detected the virus at the time of bleeding, therefore not allowing the risk imposed by asymptomatic infection to be estimated. (haematologica.org)
Leflunomide efficacy and pharmacodynamics for the treatment of BK viral infection. (semanticscholar.org)
Treatment of renal allograft polyoma BK virus infection with leflunomide. (semanticscholar.org)
More detailed information about the symptoms , causes , and treatments of BK virus infection is available below. (rightdiagnosis.com)
Wrongly Diagnosed with BK virus infection? (rightdiagnosis.com)
Visit our research pages for current research about BK virus infection treatments . (rightdiagnosis.com)
Greenlee, JE, Narayan, O & Johnson, R 1978, ' Effects of BK virus infection on primary cultures of rodent and primate cells ', Experimental Biology and Medicine , vol. 158, no. 3, pp. 437-441. (elsevier.com)
BK virus infection has emerged as a major complication in kidney transplantation leading to a significant reduction in graft survival. (biomedcentral.com)
There are currently no proven strategies to prevent or treat BK virus infection. (biomedcentral.com)
We hypothesize that administration of a quinolone antibiotic, when given early post-transplantation, will prevent the establishment of BK viral replication in the urine and thus prevent systemic BK virus infection. (biomedcentral.com)
If the full trial shows that levofloxacin significantly reduces BK infection and improves outcomes, its use in kidney transplantation will be strongly endorsed given the lack of proven therapies for this condition. (biomedcentral.com)
This major advancement in care, however, has been replaced by a new threat, BK virus infection. (biomedcentral.com)
We propose to conduct a RCT to determine if we can prevent BK virus infection from occurring rather than trying to treat the virus once replication has been established. (biomedcentral.com)
High multiplicity BK virus (BKV) infection of primary cells derived from human foetal pancreas resulted in massive cytopathology and subsequent outgrowth of cells. (microbiologyresearch.org)
Ciprofloxacin prophylaxis in kidney transplant recipients reduces BK virus infection at 3 months but not at 1 year. (jamanetwork.com)
BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. (meta.org)
Discover the latest research on BK virus infection here. (meta.org)
BK virus infection remains asymptomatic for a long time. (medindia.net)
But BK virus infection after kidney transplant can harm the patient due to reduction in immunity with potent immunosuppressive agents. (medindia.net)
The BK virus infection first appears in the urine (BK viruria) which is often associated with a high risk of transplant failure. (healthmanagement.org)
Quinolone antibiotics are known to have antiviral properties against the BK virus, but their efficacy at preventing this infection has not been shown in prospective controlled studies. (healthmanagement.org)
The study findings thus do not support the use of levofloxacin for the prevention of post-transplantation BK virus infection. (healthmanagement.org)
In recent survey, we found that people faces lots of PC trouble due to the BK LPD Virus infection. (us.com)
BK virus (BKV) infection is one of the most important opportunistic infections in renal transplant recipients (RTRs) and can cause serious allograft dysfunction [ 1 ]. (kjim.org)
The purpose of this study is to measure the rates of continuing viral presence, following anti-viral therapy with combined Peg-Interferon and Ribavirin in patients that have had a liver transplant, are immune suppressed with Neoral or tacrolimus, and have a recurring infection with the Hepatitis C virus. (mayo.edu)

The study investigated the incidence, risk factors, and clinical outcomes of BK viremia and BKVN in a Korean population of pediatric patients who received renal transplantation from 2001-2015 at the Seoul National University Hospital. (mdpi.com)
Among 168 patients assessed for BK virus status, 30 patients (17.9%) tested positive for BK viremia at a median of 12.6 months after transplantation. (mdpi.com)
Every patient with BK viremia and Alport syndrome developed BKVN, while only 11.1% of patients with BK viremia progressed to BKVN in the absence of Alport syndrome. (mdpi.com)
An anti-BK IgG- and IgA-positive phenotype at week 1 was less frequent in patients who subsequently developed viremia (14.3%) than in those who subsequently developed viruria (42.2%) ( P = 0.04). (asm.org)
Secondary outcomes include BK viremia, measures of safety (adverse events, resistant infections, Clostridium difficile -associated diarrhea), measures of feasibility (proportion of transplanted patients recruited into the trial), proportion of patients adherent to the protocol, patient drop-out and loss to follow-up,and use of quinolone antibiotics outside of the trial protocol. (biomedcentral.com)
BK virus replication progresses through specific stages: appearing first in the urine (BK viruria), then in the blood (BK viremia) and finally in the kidney transplant as an inflammatory nephritis (BK virus nephropathy)[ 6 ]. (biomedcentral.com)
Evaluation of fluoroquinolones for the prevention of BK viremia after renal transplantation. (jamanetwork.com)
Recipients of BK + donors developed BK viremia at earlier transplant time-points, had higher viral loads and slower clearing of the virus. (nephronpower.com)
Womer, KL, Patton, PR & Kaplan, B 2008, ' Aggressive post-transplant monitoring of more importance to successful outcome following re-transplantation for BK virus nephropathy than absence of pretransplant viremia ', Transplant International , vol. 21, no. 11, pp. 1103-1104. (elsevier.com)
Other measures including occurrence of BK viremia (virus in the blood), peak urine and blood viral loads, and time to sustained viruria were not significantly different between groups. (healthmanagement.org)

BK virus infections are very frequent during months following a kidney transplantation: a viral reactivation is observed for almost 50% of patients during first year. (clinicaltrials.gov)
The risk of BK virus reactivation after 1 year is greatly reduced. (oncologynurseadvisor.com)
Late onset BK reactivation in patients more than 1 year from transplant is associated with changes in immunosuppression such as steroid pulse to treat chronic rejection. (oncologynurseadvisor.com)
BK virus reactivation is a result of host predisposition, renal system damages, and immunosuppression. (oncologynurseadvisor.com)
Immediately after transplantation, severe immunosuppressive medications, used to protect the transplanted organs, can trigger BK virus reactivation and proliferation in the renal cells. (oncologynurseadvisor.com)
Factors associated with increased risk of BK virus reactivation include prior exposure to BK virus, older age of the host, and high anti-BK virus IgG levels prior to transplantation. (oncologynurseadvisor.com)
Despite frequent reactivation of BK virus in AIDS patients, clinical manifestations are extremely rare. (clinicaladvisor.com)
BKV reactivation with urinary excretion of virus occurs in 10 to 60% of kidney transplant recipients. (asm.org)
Clinical Pharmacokinetic Monitoring of Leflunomide in Renal Transplant Recipients with BK Virus Reactivation: A Review of the Literature. (semanticscholar.org)
Cytological urinary monitoring was an efficient strategy for monitoring BK virus reactivation. (altmetric.com)
In kidney transplant recipients, immunosuppression leads to reactivation of the virus. (biomedcentral.com)
determining BK virus reactivation disease in bone marrow and renal transplant patients. (umich.edu)

It has been suggested that this virus may be transmitted through respiratory fluids or urine, since infected individuals periodically excrete virus in the urine. (wikipedia.org)
This virus can be diagnosed by a BKV blood test or a urine test for decoy cells, in addition to carrying out a biopsy in the kidneys. (wikipedia.org)
Blood and urine tests will show if you are infected with the BK virus. (drugs.com)
Urine cytology for BK, Adenovirus, and CMV can contain decoy cells, which are enlarged nuclei with single basophilic intranuclear inclusion bodies. (oncologynurseadvisor.com)
Use urine polymerase chain reaction (PCR) to make a diagnosis of the culprit virus. (oncologynurseadvisor.com)
BK virus has been detected both in blood and urine. (ndtv.com)
Results from this real-time PCR assay on the LightCycler (LC PCR) were compared to a previous PCR assay (directed to VP2 region of the polyoma virus based on a published method) on 112 plasma specimens and 108 urine specimens. (mayomedicallaboratories.com)
To supplement the above data, 30 negative plasma and urine specimens were spiked with BK virus (BKV)-positive control plasmid at the approximate limit of detection (LoD). (mayomedicallaboratories.com)
Blood and urine BK polymerase chain reaction (PCR) are the favored screening tests. (renalandurologynews.com)
Detect and quantify BK virus in blood or urine. (aruplab.com)
An indirect immunofluorescence method for detection of infectious BK virus in urine. (semanticscholar.org)
article{Knowles1989AnII, title={An indirect immunofluorescence method for detection of infectious BK virus in urine. (semanticscholar.org)
An indirect immunofluorescence (IF) method is described for the detection of infectious BK virus in urine within seven days in contrast to up to three months or longer using routine tissue culture. (semanticscholar.org)
Virus is pelleted from the urine, inoculated onto pre-formed monolayers of human embryo lung (HEL) fibroblasts, and infected cells are detected in an indirect fluorescent antibody test using a human serum. (semanticscholar.org)
To determine the variability of BK virus (BKV) in vivo , the sequences of nine full-length molecular clones from the striated muscle and heart DNA of a patient with BKV-associated capillary leak syndrome (BKV CAP ), as well as three clones each from the urine of one human immunodeficiency virus type 2-positive (BKV HI ) and one healthy control subject (BKV HC ), were analysed. (microbiologyresearch.org)
The BK virus causes the tubes in the kidneys that allow urine to drain to the bladder (ureters) to swell. (osu.edu)
If levofloxacin significantly reduces BK viruria and urine viral loads in kidney transplantation, it will provide important justification to progress to the larger trial. (biomedcentral.com)
The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K. [1] The BK virus is similar to another virus called the JC virus (JCV), since their genomes share 75% sequence similarity. (hitchhikersgui.de)
According to a new study, a three-month course of levofloxacin following kidney transplantation did not prevent the BK virus from appearing in the urine. (healthmanagement.org)

Although BK viruria can occur in 0-20% of asymptomatic immunocompetent individuals, BK virus associated diseases (nephropathy, ureteral stenosis, hemorrhagic cystitis) are only seen in immunocompromised patients who had renal transplantation or hematopoietic stem cell transplantation. (oncologynurseadvisor.com)
We hypothesized that patients with positive BK viruria before unrelated or mismatched related donor allogeneic hematopoietic stem cell transplantation have a higher incidence of hemorrhagic cystitis. (haematologica.org)
Pre-transplant BK viruria detected by quantitative PCR was positive in 96 patients. (haematologica.org)
Conclusions Hemorrhagic cystitis is the result of a complex interaction of donor type, preparative regimen intensity, and BK viruria. (haematologica.org)
A rise in the optical density (OD) of anti-BK IgA (0.19), IgM (0.04), or IgG (0.38) had a sensitivity of 76.6 to 88.0% and a specificity of 71.7 to 76.1% for detection of viruria. (asm.org)
The primary outcome will be the time to occurrence of BK viruria within the first year post-transplantation. (biomedcentral.com)
Patients were tested for occurrence of BK viruria within the first year after transplantation. (healthmanagement.org)
The results showed that 29 percent of patients in the levofloxacin group and 33.3 percent of patients in the placebo group developed BK viruria. (healthmanagement.org)
We also present two renal transplant recipients with persistent BK viruria, one with BKV-associated hemorrhagic cystitis and the other with microscopic hematuria. (umn.edu)

Although polyoma BK virus (BKV)-associated interstitial nephritis has received increasing attention because of its clinical relevance in kidney allograft recipients, data on risk for repeated renal transplantation after BKV-related allograft loss are limited, and the need to perform an original graft nephrectomy is the object of debate. (nih.gov)
Type and prevalence of BK virus (BKV) infections in kidney transplant recipients. (asnjournals.org)
BK virus is a significant risk factor for kidney allograft dysfunction and loss among renal transplant recipients. (ovid.com)
In this review, we discuss diagnostic challenges and current treatment options for BK in kidney transplant recipients. (ovid.com)
In addition, novel therapeutic regimens such as adoptive transfer of targeted T cells have been described as possible treatment options for recipients with BK nephropathy. (ovid.com)
BK can also be seen in the native kidneys of pancreas, heart, lung and liver transplant recipients, suggesting that BK screening measures should be employed to other solid organ transplant recipients. (ovid.com)
BK virus (BKV) belongs to the genus Polyomaviridae and is now a well-recognized pathogen in kidney transplant recipients. (asm.org)
There has been a notable rise of BK virus among kidney transplant recipients. (eurekamag.com)
This study utilized newly collected follow-up information from the national SRTR database to investigate incidence, risk factors and outcomes for solitary kidney transplant recipients associated with treatment for BK virus (TBKV) from 2004 to 2006. (eurekamag.com)
First reported in 1995 ( 1 ), and in subsequent case series ( 2 , 3 ) BK virus-associated nephropathy (BKVAN) is estimated to occur in 2% to 10% of all kidney transplant recipients ( 4 ). (asnjournals.org)
Does reduction in immunosuppression in viremic patients prevent BK virus nephropathy in de novo renal transplant recipients? (jamanetwork.com)
Ryan J, Zanabli A, Cosio F, Stegall M, Larson T, Griffin M. Outcomes of immunosuppression reduction in BK viremic kidney transplant recipients screened at 4 months post-transplant. (jamanetwork.com)
Impact of preemptive reduction of immunosuppression with serial monitoring for BK virus replication in renal transplant recipients undergoing short-term evaluation. (jamanetwork.com)
Pre- transplant BK Screening of donors might identify the risked recipients post transplant. (nephronpower.com)
BK virus-associated nephropathy (BKVAN) is related to allograft dysfunction and graft failure in kidney transplant recipients. (transplant.news)
BK virus-associated nephropathy (BKVAN) is an important cause of allograft dysfunction in kidney transplant recipients. (kjim.org)

Although the host is not able to completely control BK virus replication, the active replication of the virus can attract immune cells to the renal system. (oncologynurseadvisor.com)
Biopsy is crucial in deciphering rejection, for which increased immunosuppression is necessary for treatment, from BK virus associated nephropathy, for which decreased immunosuppression is instrumental in halting the viral replication. (oncologynurseadvisor.com)
This paper describes the use of intravenous cidofovir for mitigating BK virus replication in transplant patients. (renalandurologynews.com)
Prestimulation of primary TEC with IFNα or dsDNA did not hamper replication of BKV, whereas influenza and herpes simplex virus 1 replication were clearly reduced. (ovid.com)
This study sought to evaluate serology and PCR as tools for measuring BK virus (BKV) replication. (asm.org)
Titers for anti-BK IgG, IgA, and IgM were higher in patients with BKV replication than in those without BKV replication. (asm.org)
Support of BK replication as well as morphological and cultural characteristics suggest an epithelial origin for the cells. (microbiologyresearch.org)
Leflunomide inhibits Polyoma virus replication in vitro and closely monitored leflunomide therapy with specifically targeted blood levels appears to be a safe and effective treatment for Polyoma BK nephropathy. (elsevier.com)
Six nuclear factor I (NFI) binding sites occur in sequences flanking the late side of the core origin (the enhancer) of the archetype virus, and their mutation, either individually or in toto, reduces BKV DNA replication when placed in competition with templates containing intact BKV NCCRs. (ucd.ie)
Its active replication has been identified to play a causative role in the development of BK virus-associated nephropathy (BKVAN) [ 5 ]. (kjim.org)

It is thought that up to 80% of the population contains a latent form of this virus, which remains latent until the body undergoes some form of immunosuppression. (wikipedia.org)
After the diagnosis of BK virus disease or the nephropathy in the transplanted kidney, first line of approach is to reduce the immunosuppression by cutting back on the dosage of various immunosuppressive medications. (ndtv.com)
For BK virus nephropathy, cidofovir, and leflunomide are effective antiviral drugs, with both BK virus and JC virus responding to the reduction of immunosuppression, and, in the case of HIV/AIDS, initiation of anti-retroviral therapy. (clinicaladvisor.com)
BKV is the consequence of modern potent immunosuppression aimed at reducing acute rejection and improving allograft survival which suppresses the immune system so well that dormant and or caught viruses can take hold. (kidneypatientguide.org.uk)
Early screening for BK combined with reduction of immunosuppression remains the mainstay of treatment for BK viraemia. (ovid.com)
Background and Objectives: BK virus-associated nephropathy (BKVAN) has emerged as a leading cause of kidney graft loss, with no known predictors for graft loss and no consensus regarding treatment other than reduction of immunosuppression. (asnjournals.org)
BK-virus and the impact of pre-emptive immunosuppression reduction: 5-year results. (jamanetwork.com)

many people who are infected with this virus are asymptomatic. (wikipedia.org)

in 2009, 12/13 patients who had their MMF exchanged with leflunomide cleared the virus by 109 days. (wikipedia.org)
Cidofovir and Leflunomide are used empirically in the treatment of BK virus nephropathy. (nih.gov)
Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation. (semanticscholar.org)
We treated twenty-six patients with biopsy proven NK virus nephropathy (BKN) with either leflunomide alone (n = 17) or leflunomide plus a course of cidofovir (n = 9) and followed them for six to forty months. (elsevier.com)

Hemorrhagic cystitis: In the setting of stem cell transplantation, Hemorrhagic cystitis can also be caused by other viruses, such as adenovirus and CMV. (oncologynurseadvisor.com)
BK virus nephropathy is seen in patients with renal transplantation and can cause worsening renal function, tubulointerstitial nephritis, ureteric stenosis, and eventual graft loss. (clinicaladvisor.com)
Nice comprehensive review of BK virus nephropathy and transplantation to include virology, epidemiology, pathology, treatment and outcomes. (renalandurologynews.com)
This paper examines the impact of prospective screening for BK virus after kidney transplantation and subsequent risk of tissue invasive disase. (renalandurologynews.com)
4 - 8 Reported predisposing factors include allogeneic transplant, advanced age at transplantation, possibly graft-versus-host disease (GVHD), thrombocytopenia, coagulopathy and viral infections (polyoma BK virus, cytomegalovirus and adenovirus). (haematologica.org)
Yi, SG , Knight, RJ & Lunsford, KE 2017, ' BK virus as a mediator of graft dysfunction following kidney transplantation ', Current opinion in organ transplantation , vol. 22, no. 4, pp. 320-327. (houstonmethodist.org)
Lunsford, Keri E. / BK virus as a mediator of graft dysfunction following kidney transplantation . (houstonmethodist.org)

A negative result (less than 2.6 log copies/mL or less than 390 copies/mL) does not rule out the presence of PCR inhibitors in the patient specimen or BK virus DNA concentrations below the level of detection of the assay. (aruplab.com)
Conclusions: The results document a pathogenic role for BK virus in native kidneys of immuno-compromised CLL patients and indicate a role for quantitative BK virus DNA detection for early management of BKVN in native kidneys. (eur.nl)
When I uploaded the LLC BK UKRBUDMONTAZH file to VirusTotal , it came up with a 11% detection rate. (freefixer.com)
BK virus DNA detection by real-time polymerase chain reaction in clinical specimens. (semanticscholar.org)
Detection or quantitation of BK virus DNA. (umich.edu)

Four patients who did not consistently have blood levels of active drug (A77 1726) above 40 μg/ml did not clear the virus until these levels were attained or cidofovir was added. (elsevier.com)

In some renal transplant patients, the necessary use of immunosuppressive drugs has the side-effect of allowing the virus to replicate within the graft, a disease called BK nephropathy. (wikipedia.org)
From 1-10% of renal transplant patients progress to BK virus associated nephropathy (BKVAN) and up to 80% of these patients lose their grafts. (wikipedia.org)
BK virus can infect and result in kidney allograft (transplanted) dysfunction, prevalence rate being around 5% within 10-12 months after having received the transplant, though it can occur much sooner as in your case. (ndtv.com)
Increasing copy levels of BK virus (BKV) DNA in serial specimens may indicate possible BKV- associated nephropathy (BKVAN) in kidney transplant patients. (mayomedicallaboratories.com)
Most of the problems from the BK virus are seen in people who have had an organ transplant. (lancastergeneralhealth.org)
Hi everyone, im new to this group can anyone tell me about the bk virus as ive just been told its scarred my transplant. (kidneypatientguide.org.uk)
Hix JK et al (2004) Delirium in a renal transplant recipient associated with BK virus in the cerebrospinal fluid. (springer.com)
However, that virus may be reactivated when a patient receives immunosuppressive therapy following an organ transplant. (rightdiagnosis.com)
If you had a virus before the transplant, a weakened immune system may result in the virus becoming active again. (osu.edu)
The purpose of this study is to use renal and kidney plus pancreas transplant patient samples to validate both the clinical utility of the CMV scoring algorithm and develop a clinically useful scoring guide for the BK virus immune competence assay. (mayo.edu)

Are you sure your patient has BK associated nephropathy (PVAN), ureteral stenosis, or hemorrhagic cystitis? (oncologynurseadvisor.com)
How did the patient develop BK associated nephropathy (PVAN), ureteral stenosis, or hemorrhagic cystitis? (oncologynurseadvisor.com)

There is a need to develop more effective and less toxic anti-BK virus drugs for clinical use. (nih.gov)
Among study participants, 790 were considered seropositive for anti-BK virus antibodies and all analyses were conducted on transformed data. (ox.ac.uk)
Otherwise, there were few consistent associations between anti-BK virus antibodies and any social and lifestyle factor investigated. (ox.ac.uk)
No other cancer site or type was significantly associated with low, or with high anti-BK virus antibody titres. (ox.ac.uk)

BK virus-associated nephropathy (BKVAN) causes renal allograft dysfunction. (physiciansweekly.com)

Although without any clinical symptoms, footprints of BK virus have been detected in specimens from females affected by spontaneous abortion. (wikipedia.org)
Polyomaviruses are small (45 nm, approximately 5,000 bp), DNA-containing viruses and include 3 closely related viruses of clinical significance: Simian virus 40 (SV-40), JC virus (JCV), and BK virus (BKV). (mayomedicallaboratories.com)
What are the key conclusions for available clinical trials and meta-analyses that inform control of viruses - polyomaviruses (John Cunningham and BK)? (clinicaladvisor.com)
Tan SC et al (2010) Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. (springer.com)
Reploeg MD, Storch GA, Clifford DB (2001) BK virus: a clinical review. (springer.com)

These are known as primary BK infections. (wikipedia.org)
What is the role of and impact of viruses - polyomaviruses (John Cunningham and BK) or infections and the need for control relative to infections at other sites or other specific pathogens? (clinicaladvisor.com)

The BK virus is a virus that mainly infects the kidneys and urinary tract. (lancastergeneralhealth.org)
BK virus (BKV) is a DNA virus that typically infects children and remains latent in the immunocompetent host. (renalandurologynews.com)

Serum antibodies against BK virus have also been found in spontaneous abortion affected women as well as in women who underwent voluntary interruption of pregnancy. (wikipedia.org)
As part of an epidemiological study of cancer in Uganda, we investigated the titre of antibodies against BK virus among 821 people with different cancer types and benign tumours. (ox.ac.uk)

Retransplantation after kidney graft loss due to polyoma BK virus nephropathy: successful outcome without original allograft nephrectomy. (nih.gov)
BACKGROUND: BK virus-associated nephropathy (BKVN) is associated with an increased risk of graft failure. (elsevier.com)
Polyoma BK virus produces an aggressively destructive nephropathy in approximately 3% to 8% of renal allografts, is associated with graft loss within one year in 35% to 67% of those infected and there is no therapy of proven efficacy. (elsevier.com)

If the kidney function doesn't improve over a period of few weeks to months, then one would be treated with antiviral agents against the BK virus. (ndtv.com)

This assay does not cross react with other polyomaviruses, including JC virus and Simian virus 40 (SV-40). (mayomedicallaboratories.com)
BK virus (BKV) is a member of the Polyomaviridae family, which also includes the well-studied simian virus 40 (SV40) and human JC virus (JCV) ( 21 ). (asm.org)

The virus then disseminates to the kidneys and urinary tract where it persists for the life of the individual. (wikipedia.org)
The next step is to have another kidney biopsy to determine if the virus is still causing active inflammation in my kidneys. (blogspot.com)

Some centers now perform pre-emptive monthly screening of blood for BK virus by polymerase chain reaction. (clinicaladvisor.com)

If the assay DETECTED the presence of the virus but was not able to accurately quantify the number of copies, the test result will be reported as 'Not Quantified. (aruplab.com)
Levels of immunoglobulin G (IgG), IgM, and IgA against BKV capsids were measured at five time points for 535 serial samples from 107 patients by using a virus-like particle-based enzyme-linked immunosorbent assay. (asm.org)
This assay does not detect JC virus or SV-40 (other polyomaviruses). (mayocliniclabs.com)

A kidney biopsy is a procedure to remove a small amount of tissue from your kidney to see if you are infected with the BK virus. (drugs.com)

The main polyomaviruses causing disease in humans are the BK, MK (Merkel cell virus), SV40 (simian vacuolating virus), and JC (John Cunningham) viruses. (clinicaladvisor.com)

Study design: Quantitative BK virus DNA in plasma and relevant immune parameters were recorded in one CLL patient with BKVN and ten consecutive CLL patients without BKVN. (eur.nl)

Specimens sent for BK Virus DNA testing require a dedicated sample and cannot be shared with other laboratories. (umich.edu)
Specimens with unknown levels of BKV DNA are then compared to the standard curve to determine the copy level of the virus. (mayocliniclabs.com)

There are several courses of treatment for BK virus. (osu.edu)

JC virus causes progressive multifocal leukoencephalopathy (PML) in patients with HIV/AIDS. (clinicaladvisor.com)
Daveson KL (2013) BK virus-associated progressive multifocal leukoencephalopathy. (springer.com)
Chu J et al BK virus-associated progressive multifocal leukoencephalopathy. (springer.com)

If your immune system becomes weak, the virus may become active and you may have symptoms. (drugs.com)
Nephropathy (PVAN): Transplanted kidney rejection can also present with similar symptoms and signs as BK virus associated nephropathy. (oncologynurseadvisor.com)
It is caused by the monkeypox virus and is characterized by rash or pox-like symptoms. (medindia.net)

The virus causes a condition called BK Viral Nephritis or BKVN. (osu.edu)

At engraftment of stem cells, the newly reconstituted immune response can result in an influx of BK virus-specific immune cells and cause further damage by the inflammatory response. (oncologynurseadvisor.com)

The viruses remain latent in multiple organ systems, particularly the genitourinary system and the central nervous system. (clinicaladvisor.com)
BKV specifically evades innate immunity in TEC and is not susceptible to an intrinsic interferon response, which may facilitate latent presence of the virus in this cell type. (ovid.com)
Aproximately 80% of the population contains a latent form of BK virus, which manifests in cases of immunosupression. (lalpathlabs.com)
the virus thereafter remains latent in the renal tubules and uroepithelial cells, which are the most important sites epidemiologically [ 2 ]. (kjim.org)

BK viral load levels in the patient steadily increased and exceeded those of the control CLL patients. (eur.nl)

Five of eleven cancers of the urinary tract were BK-virus positive. (diva-portal.org)

What are the key principles of preventing viruses - polyomaviruses (John Cunningham and BK)? (clinicaladvisor.com)
What national and international guidelines exist related to viruses - polyomaviruses (John Cunningham and BK)? (clinicaladvisor.com)

Anatomy10

Organisms113

Diseases25

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes44

Disciplines and Occupations1

Information Science4

Health Care2

A possible contributory role of BK virus infection in neuroblastoma development. (1/481)

Concerted expression of BK virus large T- and small t-antigens strongly enhances oestrogen receptor-mediated transcription. (2/481)

Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice. (3/481)

BK and JC viruses in patients with systemic lupus erythematosus: prevalent and persistent BK viruria, sequence stability of the viral regulatory regions, and nondetectable viremia. (4/481)

JC and BK virus sequences are not detectable in leukaemic samples from children with common acute lymphoblastic leukaemia. (5/481)

Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC virus and BK virus. (6/481)

Polyomaviruria in renal transplant patients is not correlated to the cold ischemia period or to rejection episodes. (7/481)

Documenting the epidemiologic patterns of polyomaviruses in human populations by studying their presence in urban sewage. (8/481)

Polyomavirus Infections

Polyomavirus

Tumor Virus Infections

BK Virus

JC Virus

Polyomaviridae

Simian virus 40

RNA Viruses

DNA, Viral

Virus Replication

Vaccinia virus

Urine

Cystitis

Receptors, Virus

Kidney Transplantation

Virus Cultivation

Genes, Viral

Virus Shedding

Antigens, Viral

Virus Diseases

Virus Assembly

Plant Viruses

DNA Viruses

Defective Viruses

Polymerase Chain Reaction

Sindbis Virus

Measles virus

Influenza A Virus, H1N1 Subtype

Vero Cells

Rabies virus

Kidney Diseases

Cell Transformation, Viral

Cercopithecus aethiops

Influenza A Virus, H5N1 Subtype

Viremia

Viral Proteins

Influenza A Virus, H3N2 Subtype

Cell Line

Hepatitis B virus

West Nile virus

Antiviral Agents

Respiratory Syncytial Viruses

Molecular Sequence Data

Viral Load

Virus Activation

Cytopathogenic Effect, Viral

Virus Physiological Processes

RNA, Viral

Vesicular stomatitis Indiana virus

Capsid Proteins

Antibodies, Viral

Virus Latency

Kidney

Hemagglutinin Glycoproteins, Influenza Virus

Oncogenic Viruses

Haplorhini

Cricetinae

Simian immunodeficiency virus

Mumps virus

Antigens, Polyomavirus Transforming

Virology

Parainfluenza Virus 1, Human

Mosaic Viruses

Virion

Hepatitis A virus

Semliki forest virus

Avian Sarcoma Viruses

Cells, Cultured

Viral Plaque Assay

Neutralization Tests

Virus Attachment

Viruses, Unclassified

DNA Restriction Enzymes

Large-Conductance Calcium-Activated Potassium Channels

Avian leukosis virus

Phylogeny

Orthomyxoviridae

Bluetongue virus

Orthomyxoviridae Infections

Gene Expression Regulation, Viral