Halogenated anti-infective agent that is used against trematode and cestode infestations.
Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.)
Infections with true tapeworms of the helminth subclass CESTODA.
A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
A subclass of segmented worms comprising the tapeworms.
Agents used to treat tapeworm infestations in man or animals.

Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis. (1/11)

Fasciola hepatica, an endemic parasite in Turkey, is still a very rare cause of cholestasis worldwide. Through ingestion of contaminated water plants like watercress, humans can become the definitive host of this parasite. Cholestatic symptoms may be sudden but in some cases they may be preceded by a long period of fever, eosinophilia and vague gastrointestinal symptoms. We report a woman with cholangitis symptoms of sudden onset which was proved to be due to Fasciola hepatica infestation by an endoscopic retrograde cholangiography.  (+info)

Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. (2/11)

The Slack (sequence like a calcium-activated K channel) and Slick (sequence like an intermediate conductance K channel) genes, which encode sodium-activated K+ (K(Na)) channels, are expressed at high levels in neurons of the medial nucleus of the trapezoid body (MNTB) in the auditory brainstem. These neurons lock their action potentials to incoming stimuli with a high degree of temporal precision. Channels with unitary properties similar to those of Slack and/or Slick channels, which are gated by [Na+]i and [Cl-]i and by changes in cytoplasmic ATP levels, are present in MNTB neurons. Manipulations of the level of K(Na) current in MNTB neurons, either by increasing levels of internal Na+ or by exposure to a pharmacological activator of Slack channels, significantly enhance the accuracy of timing of action potentials at high frequencies of stimulation. These findings suggest that such fidelity of timing at high frequencies may be attributed in part to high-conductance K(Na) channels.  (+info)

Evaluation of marked rise in fecal egg output after bithionol administration to horse and its application as a diagnostic marker for equine Anoplocephala perfoliata infection. (3/11)

To establish a reliable diagnostic measure for equine Anoplocephala perfoliata infection, the impact of deworming was examined in 12 Thoroughbreds to which bithionol (5-10 mg/kg body weight) was administered and feces were examined by the modified Wisconsin method using sucrose solution. One day after the administration, cestode eggs were detected in previously fecal egg-negative 3 horses and increased in the other 9 horses. The optimum time for post-deworming egg detection was examined in following horses: 17 mares were administered bithionol and 10 mares were used as controls. The fecal egg count was significantly (P<0.01) higher one day after the administration than that on other pre- and post-administration days, while no significant changes occurred in fecal egg count in the controls, demonstrating that one day after bithionol administration is the optimum time for detecting fecal cestode eggs. The diagnostic deworming involving bithionol and fecal examination on the day following administration provides a reliable diagnosis for equine Anoplocephala perfoliata infection.  (+info)

Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics. (4/11)

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Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity. (5/11)

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Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration. (6/11)

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Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens. (7/11)

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In vitro inhibition of Giardia lamblia and Trichomonas vaginalis growth by bithionol, dichlorophene, and hexachlorophene. (8/11)

Bithionol, dichlorophene, and hexachlorophene, which are used in treating some helminthic infections, killed trophozoites of Giardia lamblia and Trichomonas vaginalis in modified BI-S-33 and Asami media, respectively. Virtually all G. lamblia and T. vaginalis cells were killed within 24 h with a 0.42 mM concentration of these compounds, except that 0.93 mM dichlorophene was required for sterilizing T. vaginalis in the same period. In modified BI-S-33 and Asami media from which bovine and human sera were omitted, respectively, the inhibitory actions of the compounds against in vitro growth of these protozoa were significantly enhanced. Trophozoites of G. lamblia and T. vaginalis could be killed in shorter than 10 min with 0.074 mM dichlorophene and 0.0025 mM hexachlorophene, respectively, in serum-free media. G. lamblia, which was incubated in the complete medium containing dichlorophene, showed a characteristic swelling of the ventral side which led to disruption of the parasite, whereas bithionol caused a thin crack in the cytoplasm of T. vaginalis incubated in Asami medium. The crack appeared to enlarge and result in vacuolization of T. vaginalis. These observations suggest that bithionol, dichlorophene, and hexachlorophene merit further evaluation to ascertain whether they are useful for treatment of giardiasis and trichomoniasis.  (+info)

Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of cisplatin in combination with Bithionol (BT) against a panel of ovarian cancer cell lines with special focus on cisplatin-sensitive and cisplatin-resistant cell lines. The primary objectives of this study are to determine the nature of the interactions between BT and cisplatin and to understand the mechanism(s) of action of BT-cisplatin combination. The cytotoxic effects of drugs either alone or in combination were evaluated using presto-blue assay. Cellular reactive oxygen species were measured by flow cytometry. Immunoblot analysis was carried out to investigate changes in levels of cleaved PARP, XIAP, bcl-2, bcl-xL, p21 and p27. Luminescent and colorimetric assays were used to test caspases 3/7 and ATX activity. The efficacy of the BT-cisplatin combination depends upon the cell type and
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Human skin is a continual target for chemical toxicity, due to its constant exposure to xenobiotics. The skin possesses a number of protective antioxidant systems, including glutathione and enzymic pathways, which are capable of neutralising reactive oxygen species (ROS). In combination with certain chemicals, the presence of ROS might augment the levels of toxicity, due to photoactivation of the chemical or, alternatively, due to an oxidatively-stressed state in the skin which exisited prior to exposure to the chemical. Bithionol is a phototoxic anti-parasitic compound. The mechanism of its toxicity and the possible methods of protection from its damaging effects have been explored. The capacity of keratinocytes to protect themselves from bithionol and other phototoxic chemicals has been investigated. In addition, the potential of endogenous antioxidants, such as vitamin C and E, to afford protection to the cells, has been evaluated. The intracellular glutathione stores of HaCaT keratinocytes ...
Editors choice: Drug repurposing screens using worm and patient fibroblast models of PMM2-CDG led to the discovery of epalrestat, the first activator of PMM2 that targets the root cause of disease. ...
A very rare cause is a condition where too much insulin is produced in short bursts from abnormal tissue in the pancreas (an insulinoma)...
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II ...
The Alliance receives core funding from the Australian Government Department of Health. The National Rural Health Alliance acknowledges Traditional Owners of Country throughout Australia and recognises their continuing connection to lands, waters and communities ...
Hexachlorophene, also known as Nabac, is an organochlorine compound that was once widely used as a disinfectant. The compound occurs as a white odorless solid, although commercial samples can be off-white and possess a slightly phenolic odor. It is insoluble in water but dissolves in acetone, ethanol, diethyl ether, and chloroform. In medicine, hexachlorophene is a useful as a topical anti-infective, anti-bacterial agent, often used in soaps and toothpaste. It is also used in agriculture as a soil fungicide, plant bactericide, and acaricide. In 1972, the U.S. Food and Drug Administration (FDA) halted the production and distribution of products containing more than 1% of hexachlorophene. After that point, most products that contain hexachlorophene were available only by prescription from a doctor. The restrictions were enacted after 15 deaths in the United States and 39 deaths in France were reported following brain damage caused by hexachlorophene. At least three companies manufactured ...
An antiseptic kills the bacteria or prevents the multiplication of bacteria. These also prevent pus formation. Antiseptics do not harm living tissues. Tincture iodine, phenol (0-2%), dettol, chloroxylenol, etc. are applied on skin and bactrim, septran, etc. are taken orally as pills. Bad odour coming out of the wounds due to bacterial decomposition on the body or in the mouth are also reduced by the use of antiseptics.. For such purposes, antiseptics are usually incorporated in face-powder, breath purifiers, deodorants, etc. to reduce the inten-sity of bad odour. Neem soaps containing the extract of neem seeds are also used as antiseptic soaps. Dettol is a mixture of chloroxylenol and terpineol in a suitable solvent is commonly used antiseptic. Bithionol antiseptic is added to soap to provide antiseptic properties to it. Tincture iodine is 2-3% solution of iodine in alcohol and water ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Drug repurposing or re-profiling has been the hallmark to bring strong business growth and the trend is being followed by majority of the pharmaceutical an
A novel machine-learning technique leverages gene expression data to improve drug repurposing and can even predict new associations based on incomplete data.
Market research report on drug repurposing service provides with a focus on current market landscape and future growth opportunities
>Salmonella Typhimurium DT8 was a very rare cause of human illness in Ireland between 2000 and 2008, with only four human isolates from three patients being identified. Over a 19-month period between August 2009 and February 2011, 34 confirmed cases and one probable case of Salmonella Typhimurium DT8 were detected, all of which had an MLVA pattern 2-10-NA-12-212 or a closely related pattern. The epidemiological investigations strongly supported a link between illness and exposure to duck eggs. Moreover, S. Typhimurium with an MLVA pattern indistinguishable (or closely related) to the isolates from human cases, was identified in 22 commercial and backyard duck flocks, twelve of which were linked with known human cases. A range of control measures were taken at farm level, and advice was provided to consumers on the hygienic handling and cooking of duck eggs. Although no definitive link was established with a concurrent duck egg-related outbreak of S. Typhimurium DT8 in the United Kingdom, it seems
Biovista Vizit is a visual exploration tool for biomedical literature based on NCBI PubMed. Vizit allows scientists to search and explore a biomedical domain, such as a disease, a pathway or a gene, and to create biomedical networks and graphs.
A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the Institutes organ-on-a-chip (Organ Chip) technology to
Question: Dear Moriel.org I have much appreciation and thanks for the service your site provides to the Church at large. I think your article opposing...
A unique collection of 1154 clinical compounds for high throughput screening (HTS) and high content screening (HCS). • Research areas include anticancer, anti-infection, anti inflammation, nervous disease, and more. • A useful tool for drug repurposing. • Currently in clinical stage, some are withdrawn or terminated. • Structurally diverse, medicinally active, and cell permeable. • Detailed compound information with structure, IC50, and brief introduction. • Validated NMR and HPLC to ensure high purity and quality. • All compounds are in stock and continuously updated. ...
Zamani M, Sharifi Tehrani A, Ali Abadi AA (2007). Evaluation of antifungal activity of carbonate and bicarbonate salts alone or in combination with biocontrol agents in control of citrus green mold. Communications in Agricultural and Applied Biological Sciences. 72 (4): 773-7. PMID 18396809 ...
Preface xvi. Abacacavir (Ziagen) 435. Abacavir + Lamivudine + Dolutegravir (Triumeq) 381. Acyclovir (Zovirax) 442. Adefovir (Hepsera) 187. Albendazole (Albenza) 3. Amikacin (Amikin) 9. Amoxicillan 11. Amoxicillin-Clavulanate (Augmentin, Augmentin 600ES, Augmentin XR) 32. Amphotericin B (Fungizone) 169. Amphotericin B Colloidal Dispersion - ABCD (Amphotec) 13. Amphotericin B Lipid Complex (Abelcet) 1. Ampicillin 15. Ampicillin-Sulbactam (Unasyn) 394. Anidulafungin (Eraxis) 149. Artemether/Lumefantrine (Coartem) 92. Artesunate 27. Atazanavir (Reyataz) 317. Atazanavir + Cobicistat (Evotaz) 152. Atovaquone (Mepron) 240. Atovaquone/Proguanil (Malarone) 230. Azithromycin (Zithromax, Zmax) 437. Aztreonam (Azactam) 40. Bedaquiline (Sirturo) 337. Benznidazole 51. Bithionol (Bitin) 57. Capreomycin (Capastat) 62. Caspofungin (Cancidas) 60. Cefaclor 66. Cefadroxil (Duricef) 135. Cefamandole (Mandol) 232. Cefazolin (Ancef) 18. Cefdinir (Omnicef) 270. Cefditoren Pivoxil (Spectracef) 343. Cefepime (Maxipime) ...
Along the lines that have been discussed in a recent Frontiers short paper, here is a list of our patent discussions in the December 2017 drug repurposing special issue of ASSAY and Drug Development Technologies:. WO/2017/059389 (Kythera Biopharmaceuticals, USA): Statins as an alternative to liposuction and cryolipolysis. WO/2017/060308 (AB Science, France): Masitinib switches to human use. WO/2017/066421 (Ovid Therapeutics, USA): Eplivanserin for improving cognition in psychoses. WO/2017/068143 (Individual, Germany): BAY 11-7082 or dimethyl fumarate for adiposity or cardiovascular diseases. WO/2017/080919 (Freiburg University, Germany): Roflumilast for metabolic lipid disorders. WO/2017/081609 (Individuals): Febuxostat: from gout to neurology. WO/2017/085407 (Pierre et Marie Curie University et al., France): Mirabegron, an overactive bladder drug, for macular degeneration. WO/2017/091644 (AZ Therapies, USA): Cromolyn for cerebral ischemia and dementia. WO/2017/096013 (Cornell University, USA): ...
The platform for pet owners and breeders that contains all the important information at a glance. LABOKLIN has many years of experience with the implementation and development of genetic tests, particularly in the areas of genetic disorders, colour analysis, DNA profiles, ancestry and sex determination in birds. Our high quality standard is characterised particularly by the fact that all the results of our genetic studies are controlled in a second independent test run before they are shipped. ...
Noncyclical breast pain. This type of breast pain is not related to periods and is most common in women aged over 40. Pain can be present all the time, or come and go in a random way. The pain may be in just one breast, and may be localisedtoan area in breast .Reasonof this pain is unknown in most cases, however in few cases it might be due to,muscular or bony problems of the chest wall or Infection .Breast tumours, cancer are very rare cause of breast pain.The symptom of breast cancer is usually a painless lump. Pain is not usually an early symptom. As there are various causes it is best to see a doctor for assessment. What is the treatment for noncyclical breast pain?. NSAIDs such as ibuprofen may ease the pain. Topical NSAIDs may also work. Other treatments may be appropriate, depending on whether a cause is found.. ...
Hexachlorophene is a toxic chemical that induces edema, membrane damage, and increased sodium /decreased potassium in brain cells. (Hexachlorophene was used in shampoos, soaps and other personal care products until about a decade ago.) Rats were fed hexachlorophene orally for 3 weeks, then given Piracetam or one of 5 other drugs by injection for 6 days. Hexachlorophene seriously disrupted the rats ability to navigate a horizontal ladder without frequently falling off the rungs. Piracetam reduced the fall rate 75% compared to saline-injected controls on the first day of treatment. None of the other drugs came close to that improvement. (24). Piracetam increases the survival rate of rats subjected to severe hypoxia. (1,25) When mice, rats and rabbits have been put under diverse experimental hypoxic (low oxygen) conditions, Piracetam has acted to attenuate or reverse the hypoxia-induced amnesia and learning difficulties, while speeding up post-hypoxic recovery time and reducing time to renormalize ...
Steve Braun of Cures Within Reach, a nonprofit focused on breathing new life into old medicines, describes the potential benefits of drug repurposing.. 1 Comment. ...
Steve Braun of Cures Within Reach, a nonprofit focused on breathing new life into old medicines, describes the potential benefits of drug repurposing.. 1 Comment. ...
Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.. ...
Find the Q&A between Director of Scientific Consulting, Dr. Maciej Czerwinski, and the editorial team at Outsourcing Pharma for more answers about how DDI testing and data interpretation adds value to the drug repurposing process. ...
Slack and sales, together? In a word, yes. Combined with the power of Salesforce, Slack helps sales teams close deals and grow revenue fast.
Slack is where work flows. Its where the people you need, the information you share, and the tools you use come together to get things done.
Urease is a nickel-dependent amidohydrolase that catalyses the decomposition of urea into carbamate and ammonia, a reaction that constitutes an important source of nitrogen for bacteria, fungi and plants. It is recognized as a potential antimicrobial target with an impact on medicine, agriculture, and the environment. The list of possible urease inhibitors is continuously increasing, with a special interest in those that interact with and block the flexible active site flap. We show that disulfiram inhibits urease in Citrullus vulgaris (CVU), following a non-competitive mechanism, and may be one of this kind of inhibitors. Disulfiram is a well-known thiol reagent that has been approved by the FDA for treatment of chronic alcoholism. We also found that other thiol reactive compounds (l-captopril and Bithionol) and quercetin inhibits CVU. These inhibitors protect the enzyme against its full inactivation by the thiol-specific reagent Aldrithiol (2,2′-dipyridyl disulphide, DPS), suggesting that the three
Abstract Between 1974 and 1985, 10 patients were studied who presented with either gastrointestinal complaints or unexplained peripheral blood eosinophilia, and had eggs typical for N. salmincola recovered from their stools. Clinical findings in 8 of the 10 included increased frequency of bowel movements or diarrhea (6), peripheral blood eosinophilia (6), abdominal discomfort (5), nausea and vomiting (3), weight loss (2), and fatigue (2). Two were asymptomatic. Eight recalled eating fish prior to the onset of symptoms. Anthelminthic treatment consisting of three 2-g doses of niclosamide (2 patients) or two 50 mg/kg doses of bithionol (1 patient) proved effective. In the remaining individuals symptoms resolved slowly over several months.
Findacure has found an innovative way to use this financial tool to fund drug repurposing research for rare diseases. This is the rare disease drug repurposing social impact bond - RDDR SIB for short.. But how would it work?. Our SIB is based on the premise that successfully repurposing low cost generic drugs for rare disease patients will save the NHS money. Rare diseases left untreated cost the NHS lots in surgery, care, appointments, hospital, stays, and much more - a cost that can be significantly reduced by a cheap, repurposed treatment. The NHS can then use a portion of these savings to reimburse Findacure for the cost of the clinical trial. We will use this reimbursement to pay back private investors, whose money was required to initially run the trial. Surplus reimbursement will be invested by us in more clinical trials: the project is self-sustaining and non-profit.. ...
Hexachlorophene is a broad spectrum anti-bacterial agent. It is used in hospital scrubs, shampoos, and deodorants. Once widely used in over-the-counter products, hexachlorophene is now prescription-only, after overdose incidents in infants in France in the 1970s. It has been largely replaced by the related compound Triclosan. ...
The virus is still found in tropical and subtropical areas in South America and Africa and remains a very rare cause of illness in U.S. travelers, according to CDC.
You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our cookies policy. ...
Congenital abnormalities of the cardiovascular system are defects that are present at birth. They can occur as a result of genetic defects, environmental conditions, infections, poisoning, medication taken...
Health officials have confirmed the presence of Exserohilum rostratum in unopened recalled steroid vials from New England Compounding Pharmacy.
The drug repurposing workflow system screens at least 20 bacterial proteomes against this set of proteins that are already being treated against using established drugs. By screening the bacterial proteomes it will be possible to find proteins of highly similar structure to those that are existing drug protein targets and so this will infer that it is highly likely that the drugs can be used as antimicrobials against these proteins of highly similar structure. Proteomes that will be screene ...
CXCL7 (Human) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for quantitative detection of human CXCL7 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). (KA5605) - Products - Abnova
Comparative Studies on Some Biology and Pathology of Corn and Broom Corn Isolates of Exserohilum turcicum (Pass) Leonard & Suggs ...
In 2019, IPOs ended in face-plants for some of the biggest unicorns: WeWork, Uber, Lyft, Slack, and Pinterest. Expect no lessons to be learned.
Authors. Andrew K. Gonsalves, Educational Specialist. Stephen A. Ferreira, Extension Plant Pathologist. Department of Plant Pathology, College of Tropical and Agriculture and Human Resources. University of Hawaii at Manoa. PATHOGENS & HOSTS. Over four Exserohilum species have been reported to occur in Hawaii (Raabe, et al., 1981). The following is a list of the reported pathogens from this genus (Exserohilum) and the hosts they infect. The list is organized by the scientific name of the pathogen species (CAPITAL LETTERS), followed by the various susceptible plant hosts. Words in blue indicate what symptom or disease a given pathogen causes on the listed hosts.. EXSEROHILUM PEDICELLATUM. Leafspot:. corn, maize (Zea mays). EXSEROHILUM ROSTRATUM. Flower Fleck:. Dendrobium sp.. Seedling Blight:. sorghum (Sorghum bicolor). feterita (Sorghum caudatum). EXSEROHILUM SP.. Leafspot:. golden-fruited palm (Chrysalidocarpus lutescens). Manilla grass (Zoysia matrella). ?mascarene grass (Zoysia ...
Insilico Medicine will present its recent advances in applying deep learning techniques to drug discovery and repurposing at the Strategic Partnerships in Drug Repurposing conference in Boston taking place at the Wyndham Boston Beacon Hill Oct. 27-28.
Nearly all the genes in human DNA have two copies, one inherited from the mother and one from the father. There are some genetic diseases where only one copy is normal and the other one is non-functional due to a mistake in the DNA. The idea behind this study was to see if the normal copy can be enhanced to make up for the non-functional copy, said Ali Djalilian, UIC professor of ophthalmology and corresponding author of the paper. Researchers used a mouse model of the human disease aniridia, an eye disorder that affects the iris and causes substantial visual impairment and can also be associated with systemic abnormalities. In aniridia, one copy of the gene PAX6 is normal and the other copy is non-functional. The PAX6 gene is important in eye development and patients with aniridia and PAX6 deficiency are born with eye problems, which limit their vision and can progress throughout life, Djalilian said. The investigators screened drugs that can enhance PAX6 and found a particular class of drugs ...
6:30 pm Reception and Dinner and Remarks by APMRF. June 5, 2017 8:00 am Breakfast. Presentations. There will be opportunities to submit abstracts for talks and the poster session. All submissions are due by April 1, 2017.. Speakers include:. Keynote address by Dr. Thijn Brummelkamp, Genetic studies on the function of NPC1 in pathogen entry and cholesterol trafficking. Dr. Roberto Zonco, Mechanisms of cholesterol sensing by the master growth regulator mTORC1 kinase. Dr. Wei Zheng, Therapeutic development for treatment of NPC: beyond cyclodextrin. Dr. Arun Radikrishnan, Intracellular trafficking routes of cholesterol. Dr. Kenji Ohgane, Identification of Chaperone Drugs for NPC through Drug Repurposing Screening. Dr. Yiannis Loannou, Targeting the Mitochondria-ER-Lysosome axis for the treatment of multiple lysosomal storage diseases. Dr. Charles Vite, Gene therapy in the CNS in large animal models. Dr. Xuntian Jiang, Biomarker discovery and development of diagnostics for early detection of NPC ...
BIONEXT is a French biotechnology company dedicated to the better understanding and treatment of various diseases. BIONEXT aims to accelerate and improve the effectiveness of drug development and biological research by developping programs and software-based tools to tackle problematics of prime importance in the pharmaceutical field, such as drug profile assesment or suggestion of drug repurposing.
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow. ...
Plxna1 (Rat) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for quantitative detection of rat Plexin A1 in cell culture supernates, serum and plasma (heparin, EDTA). (KA5555) - Products - Abnova
Salesforce is one of the worlds largest players in the cloud computing sector. They will buy Slack Technologies, the owner of Slacks corporate messenger. The Wall Street Journal reports, Messenger will cost Salesforce $ 27.7 billion, which will be the largest acquisition of the company in its history.. The terms of the deal include that Slack shareholders will receive $ 26.79 billion in cash and 0.0776 ordinary Salesforce shares for each Slack share. According to a company press release, at the closing price of ordinary shares of Salesforce on November 30 ($ 245.8), it gives a total of $ 27.7 billion.. The deal is expected to be completed in the second quarter of next fiscal year Salesforce, i.e. from May to July 2021.. The first reports of a possible deal between Slack and Salesforce appeared last week. During this time, Slack Technologies quotes rose by 47%. At the same time, Salesforce securities for the same period asked for almost 10%. Trading on December 1 quoted Salesforce quotes down ...
Bithionol for human therapeutic use. Bragantia spp. containing aristolochic acid(s) for human therapeutic use. Buclosamide for ...
Praziquantel is not effective, and older drugs such as bithionol are moderately effective but also cause more side effects. ... There are also reports of bithionol being used successfully. Nitazoxanide has been found effective in trials, but is currently ... Fasciolicides (drugs against Fasciola spp.) fall into five main chemical groups: Halogenated phenols: bithionol (Bitin), ...
Drugs used to treat infestation include triclabendazole, praziquantel, bithionol, albendazole, levamisole, and mebendazole. ...
The drug of choice to treat paragonimiasis is praziquantel, although bithionol may also be used. Triclabendazole is useful in P ...
... and bithionol. Ivermectin, which is widely used for many helminthic parasites, has low effectivity against F. hepatica, as does ...
Other medications can also be used such as bithionol, niclofan, and triclabendazole with high cure rates. Thorough cooking of ...
To obtain the worms from the host, piperazine citrate, levamisole and bithionol can be administered to the patient. ...
Bithionol is an alternative drug for treatment of this disease but is associated with skin rashes and urticaria. For additional ...
100 mg bithionol/kg B.W. or 200 mg bithionol/kg B.W. significantly reduces the numbers of this monogenean on the gills of the ... Ki Hong Kim & Eun Seok Choi evaluated the oral administration of mebendazole or bithionol for the control of Microcotyle ... with oral administration of mebendazole and bithionol". Aquaculture. 167 (1-2): 115-121. doi:10.1016/S0044-8486(98)00300-7. ...
... including bithionol, niclosamide, nicoflan, and Praziquantel. All drugs showed lower prevalence of eggs in feces, however only ...
Three 2-g doses of niclosamide or two 50 mg/kg doses of bithionol have also been effective when praziquantel was either not ...
... unlike the previously used drug bithionol, which required extended treatment and involved more severe side effects. The latest ...
On the other hand, there are other antihelminthic drugs available such as bithionol, thiabendazole, metronidazole, and others, ...
Several compounds of well-known antiprotozoal activity, including niclosamide, oxyclozanide, bithionol sulfoxide, toltrazuril, ...
D10AA01 Fluorometholone D10AA02 Methylprednisolone D10AA03 Dexamethasone D10AB01 Bithionol D10AB02 Sulfur D10AB03 Tioxolone ...
... bithionol (INN) bithionoloxide (INN) bitipazone (INN) bitolterol (INN) bitoscanate (INN) bivalirudin (INN) bivatuzumab ...
Examples of such sodium salts are (selection): Bispyribac, bithionol, bosentan, brequinar, bromfenac, Cefmenoxime, ceftiofur, ...
... mucolytic compounds such as L-cysteine ethyl ester and the parasiticide bithionol have been tested with some success although ...
The molecular formula C12H6Cl4O2S (molar mass: 356.052 g/mol, exact mass: 353.8843 u) may refer to: Bithionol Tetradifon This ...
... fungicides benzohydroxamic acid benzothiazole fungicides bethoxazin binapacryl biphenyl bitertanol bithionol bixafen ...
QP52AG02 Hexachlorophene QP52AG03 Niclosamide QP52AG04 Resorantel QP52AG05 Rafoxanide QP52AG06 Oxyclozanide QP52AG07 Bithionol ...
P02BA01 Praziquantel P02BA02 Oxamniquine P02BB01 Metrifonate P02BX01 Bithionol P02BX02 Niridazole P02BX03 Stibophen P02BX04 ...
... was formerly used in soaps and cosmetics until the U.S. FDA banned it for its photosensitizing effects. The compound ... Bithionol has two aromatic rings with a sulfur atom bonded between them and multiple chlorine ions and hydroxyl groups attached ... Bithionol is the first known soluble adenylyl cyclase inhibitor to act through the bicarbonate binding site via a mostly ... Bithionol is an antibacterial, anthelmintic, and algaecide. It is used to treat Anoplocephala perfoliata (tapeworms) in horses ...
The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet.[10] Other skin reactions include skin rash, swelling and stinging sensation.[10] Suramin can also cause loss of appetite and irritability.[10] Suramin causes non-harmful changes in urine during use, specifically making the urine cloudy.[10] It may exacerbate kidney disease.[11] Less common side effects include extreme fatigue, ulcers in the mouth, and painful tender glands in the neck, armpits and groin.[10] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision.[10] Rare side effects include hypersensitivity reactions causing difficulty breathing. Other rare systemic effects include decreased blood pressure, fever, rapid heart ...
Bithionol was formerly used in soaps and cosmetics until the U.S. FDA banned it for its photosensitizing effects. The compound ... Bithionol has two aromatic rings with a sulfur atom bonded between them and multiple chlorine ions and hydroxyl groups attached ... Bithionol is the first known soluble adenylyl cyclase inhibitor to act through the bicarbonate binding site via a mostly ... Bithionol is an antibacterial, anthelmintic, and algaecide. It is used to treat Anoplocephala perfoliata (tapeworms) in horses ...
Bithionol , C12H6Cl4O2S , CID 2406 - structure, chemical names, physical and chemical properties, classification, patents, ...
... bithionol; and trichlorcarbanilide. 5.7 Pterygium and Cancer of the Eye While detailed epidemiological evidence does not seem ... bithionol, griseofulvin), drugs (chlortetracycline, thiazides, chlorpromazine), and, most recently, compounds deliberately used ...
Bithionol. Lenperone. Pyrimethamine. Bunamidine. Levamisole. Quinacrine. Butorphanol. Liothyronine. Quinidine. N-Butyl Chloride ...
These prohibited substances include bithionol, chloroform, mercury compounds, methylene chloride, vinyl chloride, and ... These prohibited substances include bithionol, chloroform, mercury compounds, methylene chloride, vinyl chloride, and ... These prohibited substances include bithionol, chloroform, mercury compounds, methylene chloride, vinyl chloride, and ...
The remaining non-nitroimidazoles tested (amprolium, bithionol, febantel, flubendazole, levamisole, netobimin, niclosamide, ...
The study found that bithionol, a drug that used to treat parasitic infections in horses, could be used to treat antibiotic- ... When used in high doses, bithionol causes the cells of bacteria to burst open and die-but this might cause bacteria to become ... Researchers found that using lower doses of bithionol to weaken bacteria, and then a traditional antibiotic to finish the job, ... Of course, the danger of bacteria eventually becoming resistant to bithionol, too, is ever present. But not to worry! ...
Bithionol (substance). Code System Preferred Concept Name. Bithionol (substance). Concept Status. Published. ...
The series can be seen as an important addition for those physicians who either do not have a domestic baseline series or want to go beyond the various baseline series offered. The experience has been that a larger routine screening series will produce a higher yield of positive reactions and contribute to a better diagnosis.. ...
Sulisobenzone (2), bithionol (9), doxycycline HCl (12), enoxacin (13), furosemide (14), glibenclamide (15), hydrochlorothiazide ...
... bithionol, disophenol, hexachlorophene, niclofolan, menichlopholan, nitroxynil), and the aromatic amide diamfenetide ( ...
You Wont Find Bithionol In Any Cosmetic Products. Bithionol is an antibacterial and an algaecide and is for the treatment of ...
For instance, a collaborative research project conducted amongst Brown, Harvard, and Emory University repurposed bithionol-a ...
The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet.[10] Other skin reactions include skin rash, swelling and stinging sensation.[10] Suramin can also cause loss of appetite and irritability.[10] Suramin causes non-harmful changes in urine during use, specifically making the urine cloudy.[10] It may exacerbate kidney disease.[11] Less common side effects include extreme fatigue, ulcers in the mouth, and painful tender glands in the neck, armpits and groin.[10] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision.[10] Rare side effects include hypersensitivity reactions causing difficulty breathing. Other rare systemic effects include decreased blood pressure, fever, rapid heart ...
This guide covers food contact materials, supplements, medical devices, fitness products, and other products covered by FDA regulations.
... bithionol sulfoxide, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) HCl, cyanogen Bromide, octanedioic acid, and various ...
bithionol Tablet. 200mg bleomycin Injection. 15 IU bromocryptin Tablet. 2.5mg bupivacaine Injection. 0.5% (hydrochloride) ...
This graph shows the total number of publications written about "Bromphenol Blue" by people in Harvard Catalyst Profiles by year, and whether "Bromphenol Blue" was a major or minor topic of these publication ...
Fasciola hepatica (the liver ?uke) is a further hepato-biliary helminthic infection; treatment is with bithionol or ...
The dosage and length of treatment are based on your medical condition and response to therapy. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis 1 day ago · Hydroxychloroquine and chloroquine inhibit SARS-CoV-2 in vitro, and a Chinese commentary, mentioning 15 trials, reported that, "Thus far, results from more than 100 patients have demonstrated that chloroquine phosphate is superior to the control treatment in inhibiting the exacerbation of pneumonia,"19 without giving any further details Hydroxychloroquine (HCQ), sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Initially, chloroquine was given for malaria prophylaxis and treatment Mar 19, 2020 · What Is It: Hydroxycholorquine (sold under the brand name Plaquenil), and the closely related chloroquine, were approved in the 1950s mainly as anti-malaria treatments Jan 07, 2020 · Daily ...
Bithionol chloroquine products containing , Tower Of Meaning , ...
Looking for online definition of bite pressure in the Medical Dictionary? bite pressure explanation free. What is bite pressure? Meaning of bite pressure medical term. What does bite pressure mean?
This graph shows the total number of publications written about "Bromphenol Blue" by people in this website by year, and whether "Bromphenol Blue" was a major or minor topic of these publications ...
MeSH Terms: Animals, Bacterial Proteins, Bithionol, Dichlorophen, Enzyme Inhibitors, HEK293 Cells, Hexachlorophene, Humans, ...
bithionol. chlorofluorocarbon propellants. chloroform. halogenated salicylanilides, di-, attempt-, metabromsalan and ...
Bithionol. *Blenders. *Blood Analyzers: Gas, Micro. *Blood Analyzers: Gas, Recording. *Blood Analyzers: Oxygen Saturation ...
  • Bithionol has two aromatic rings with a sulfur atom bonded between them and multiple chlorine ions and hydroxyl groups attached to the phenyl groups. (wikipedia.org)
  • The side chain of arginine 176 within the bicarbonate binding site interacts significantly with the aromatic ring of the bithionol molecule. (wikipedia.org)
  • In another form of inhibition, bithionol is a much larger molecule than simple sodium bicarbonate, so it is large enough to reach through a small channel in the soluble adenylyl cyclase and interfere with binding of ATP, preventing its conversion to cAMP. (wikipedia.org)
  • This inhibition of the soluble adenylyl cyclase by bithionol at the bicarbonate binding site is demonstrated through a mixed-inhibition graph, where higher concentrations of bithionol have a lower Vmax and a larger Km. (wikipedia.org)
  • Researchers found that using lower doses of bithionol to weaken bacteria, and then a traditional antibiotic to finish the job, was more effective. (anh-usa.org)
  • The problem is that the traditional medications, like bithionol, have many side-effects, are nasonex good price pharmacy very expensive, and many of them show no results. (sexsmithselfstorage.com)
  • The study found that bithionol, a drug that used to treat parasitic infections in horses, could be used to treat antibiotic-resistant bacteria like MRSA , which infects 90,000 Americans each year and kills 20,000. (anh-usa.org)
  • One promising drug is bithionol. (oncoloradosprings.com)
  • Bithionol is an anti-parasitic drug and can be used to inhibit solid tumor growth in several preclinical cancer models. (csnpharm.cn)
  • This graph shows the total number of publications written about "Bithionol" by people in this website by year, and whether "Bithionol" was a major or minor topic of these publications. (ucdenver.edu)
  • The Global Liver Fluke Treatment Market has been segmented by Drug Type into Triclabendazole, Praziquantel, Bithionol, Nitazoxanide and Albendazole. (reanin.com)
  • praziquantel albendazole triclabendazole, bithionol,nitazoxanide substitue with ivermectin Moreover, if they are lying about their digital footprint, you must avoid them. (draxray.com)
  • by Farmers Elevator Service Co., Inc. LABEL IN PART: (Bag) "Felco Feed Premix medicated for the prevention of Coccidiosis in Chickens * * * Active drug ingredients: Bithionol 10.0 per- cent Methitriazamine 2.0 percent * * * Manufactured for Farmers Elevator Service Company * * * Fort Dodge, Iowa. (nih.gov)
  • Bithionol, a halogenated phenol previously used as first line agent for the treatment of fascioliasis in USA is no longer available. (medscape.com)
  • Previously used to treat parasitic infections in horses, bithionol is now being used to treat MRSA (Methicillin-resistant Staphylococcus aureus) and other antibiotic resistant bacterial infections. (oncoloradosprings.com)