Bithionol: Halogenated anti-infective agent that is used against trematode and cestode infestations.Dichlorophen: Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.)Cestode Infections: Infections with true tapeworms of the helminth subclass CESTODA.Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)Cestoda: A subclass of segmented worms comprising the tapeworms.Anticestodal Agents: Agents used to treat tapeworm infestations in man or animals.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Cell Line, Tumor: A cell line derived from cultured tumor cells.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.Proguanil: A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Colloids: Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Capreomycin: Cyclic peptide antibiotic similar to VIOMYCIN. It is produced by Streptomyces capreolus.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Parabens: Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)Preservatives, Pharmaceutical: Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.Ointment Bases: Various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons; vehicles for medicinal substances intended for external application; there are four classes: hydrocarbon base, absorption base, water-removable base and water-soluble base; several are also emollients.Cosmetic Techniques: Procedures for the improvement or enhancement of the appearance of the visible parts of the body.Surgery, Plastic: The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.Esthetics: The branch of philosophy dealing with the nature of the beautiful. It includes beauty, esthetic experience, esthetic judgment, esthetic aspects of medicine, etc.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Government Agencies: Administrative units of government responsible for policy making and management of governmental activities.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.Fascioloidiasis: Infection of cattle and other herbivores with the giant liver fluke Fascioloides magna. It is characterized by extensive destruction of the liver parenchyma.Fasciolidae: A family of flukes of the class Trematoda occurring primarily in the liver of animals and man. There are six genera: Fasciola, Fasciolopsis, Fascioloides, Tenuifasciola, Parafasciolopsis, and Protofasciola. The adult form of Fasciolopsis occurs in the intestines of pigs and man.Opisthorchis: A genus of trematode liver flukes of the family Opisthorchidae. It consists of the following species: O. felineus, O. noverca (Amphimerus noverca), and O. viverrini. The intermediate hosts are snails, fish, and AMPHIBIANS.Fasciola hepatica: A species of helminth commonly called the sheep liver fluke. It occurs in the biliary passages, liver, and gallbladder during various stages of development. Snails and aquatic vegetation are the intermediate hosts. Occasionally seen in man, it is most common in sheep and cattle.Hemangioma: A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)Opisthorchiasis: Infection with flukes of the genus Opisthorchis.Fascioliasis: Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.Trematode Infections: Infections caused by infestation with worms of the class Trematoda.Trematoda: Class of parasitic flukes consisting of three subclasses, Monogenea, Aspidogastrea, and Digenea. The digenetic trematodes are the only ones found in man. They are endoparasites and require two hosts to complete their life cycle.Clonorchis sinensis: A species of trematode flukes of the family Opisthorchidae. Many authorities consider this genus belonging to Opisthorchis. It is common in China and other Asiatic countries. Snails and fish are the intermediate hosts.Paragonimus: A genus of lung flukes of the family Troglotrematidae infecting humans and animals. This genus consists of several species one of which is PARAGONIMUS WESTERMANI, a common lung fluke in humans.Clonorchiasis: Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)Fish Products: Food products manufactured from fish (e.g., FISH FLOUR, fish meal).Gynecology: A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.IllinoisObstetrics: A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.Wool: The hair of SHEEP or other animals that is used for weaving.Schools: Educational institutions.Genital Neoplasms, Female: Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).Gynecologic Surgical Procedures: Surgery performed on the female genitalia.

Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis. (1/11)

Fasciola hepatica, an endemic parasite in Turkey, is still a very rare cause of cholestasis worldwide. Through ingestion of contaminated water plants like watercress, humans can become the definitive host of this parasite. Cholestatic symptoms may be sudden but in some cases they may be preceded by a long period of fever, eosinophilia and vague gastrointestinal symptoms. We report a woman with cholangitis symptoms of sudden onset which was proved to be due to Fasciola hepatica infestation by an endoscopic retrograde cholangiography.  (+info)

Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. (2/11)

The Slack (sequence like a calcium-activated K channel) and Slick (sequence like an intermediate conductance K channel) genes, which encode sodium-activated K+ (K(Na)) channels, are expressed at high levels in neurons of the medial nucleus of the trapezoid body (MNTB) in the auditory brainstem. These neurons lock their action potentials to incoming stimuli with a high degree of temporal precision. Channels with unitary properties similar to those of Slack and/or Slick channels, which are gated by [Na+]i and [Cl-]i and by changes in cytoplasmic ATP levels, are present in MNTB neurons. Manipulations of the level of K(Na) current in MNTB neurons, either by increasing levels of internal Na+ or by exposure to a pharmacological activator of Slack channels, significantly enhance the accuracy of timing of action potentials at high frequencies of stimulation. These findings suggest that such fidelity of timing at high frequencies may be attributed in part to high-conductance K(Na) channels.  (+info)

Evaluation of marked rise in fecal egg output after bithionol administration to horse and its application as a diagnostic marker for equine Anoplocephala perfoliata infection. (3/11)

To establish a reliable diagnostic measure for equine Anoplocephala perfoliata infection, the impact of deworming was examined in 12 Thoroughbreds to which bithionol (5-10 mg/kg body weight) was administered and feces were examined by the modified Wisconsin method using sucrose solution. One day after the administration, cestode eggs were detected in previously fecal egg-negative 3 horses and increased in the other 9 horses. The optimum time for post-deworming egg detection was examined in following horses: 17 mares were administered bithionol and 10 mares were used as controls. The fecal egg count was significantly (P<0.01) higher one day after the administration than that on other pre- and post-administration days, while no significant changes occurred in fecal egg count in the controls, demonstrating that one day after bithionol administration is the optimum time for detecting fecal cestode eggs. The diagnostic deworming involving bithionol and fecal examination on the day following administration provides a reliable diagnosis for equine Anoplocephala perfoliata infection.  (+info)

Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics. (4/11)

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Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity. (5/11)

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Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration. (6/11)

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Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens. (7/11)

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In vitro inhibition of Giardia lamblia and Trichomonas vaginalis growth by bithionol, dichlorophene, and hexachlorophene. (8/11)

Bithionol, dichlorophene, and hexachlorophene, which are used in treating some helminthic infections, killed trophozoites of Giardia lamblia and Trichomonas vaginalis in modified BI-S-33 and Asami media, respectively. Virtually all G. lamblia and T. vaginalis cells were killed within 24 h with a 0.42 mM concentration of these compounds, except that 0.93 mM dichlorophene was required for sterilizing T. vaginalis in the same period. In modified BI-S-33 and Asami media from which bovine and human sera were omitted, respectively, the inhibitory actions of the compounds against in vitro growth of these protozoa were significantly enhanced. Trophozoites of G. lamblia and T. vaginalis could be killed in shorter than 10 min with 0.074 mM dichlorophene and 0.0025 mM hexachlorophene, respectively, in serum-free media. G. lamblia, which was incubated in the complete medium containing dichlorophene, showed a characteristic swelling of the ventral side which led to disruption of the parasite, whereas bithionol caused a thin crack in the cytoplasm of T. vaginalis incubated in Asami medium. The crack appeared to enlarge and result in vacuolization of T. vaginalis. These observations suggest that bithionol, dichlorophene, and hexachlorophene merit further evaluation to ascertain whether they are useful for treatment of giardiasis and trichomoniasis.  (+info)

Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of cisplatin in combination with Bithionol (BT) against a panel of ovarian cancer cell lines with special focus on cisplatin-sensitive and cisplatin-resistant cell lines. The primary objectives of this study are to determine the nature of the interactions between BT and cisplatin and to understand the mechanism(s) of action of BT-cisplatin combination. The cytotoxic effects of drugs either alone or in combination were evaluated using presto-blue assay. Cellular reactive oxygen species were measured by flow cytometry. Immunoblot analysis was carried out to investigate changes in levels of cleaved PARP, XIAP, bcl-2, bcl-xL, p21 and p27. Luminescent and colorimetric assays were used to test caspases 3/7 and ATX activity. The efficacy of the BT-cisplatin combination depends upon the cell type and
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Human skin is a continual target for chemical toxicity, due to its constant exposure to xenobiotics. The skin possesses a number of protective antioxidant systems, including glutathione and enzymic pathways, which are capable of neutralising reactive oxygen species (ROS). In combination with certain chemicals, the presence of ROS might augment the levels of toxicity, due to photoactivation of the chemical or, alternatively, due to an oxidatively-stressed state in the skin which exisited prior to exposure to the chemical. Bithionol is a phototoxic anti-parasitic compound. The mechanism of its toxicity and the possible methods of protection from its damaging effects have been explored. The capacity of keratinocytes to protect themselves from bithionol and other phototoxic chemicals has been investigated. In addition, the potential of endogenous antioxidants, such as vitamin C and E, to afford protection to the cells, has been evaluated. The intracellular glutathione stores of HaCaT keratinocytes ...
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II ...
Hexachlorophene, also known as Nabac, is an organochlorine compound that was once widely used as a disinfectant. The compound occurs as a white odorless solid, although commercial samples can be off-white and possess a slightly phenolic odor. It is insoluble in water but dissolves in acetone, ethanol, diethyl ether, and chloroform. In medicine, hexachlorophene is a useful as a topical anti-infective, anti-bacterial agent, often used in soaps and toothpaste. It is also used in agriculture as a soil fungicide, plant bactericide, and acaricide. In 1972, the U.S. Food and Drug Administration (FDA) halted the production and distribution of products containing more than 1% of hexachlorophene. After that point, most products that contain hexachlorophene were available only by prescription from a doctor. The restrictions were enacted after 15 deaths in the United States and 39 deaths in France were reported following brain damage caused by hexachlorophene. At least three companies manufactured ...
Drug repurposing or re-profiling has been the hallmark to bring strong business growth and the trend is being followed by majority of the pharmaceutical an
>Salmonella Typhimurium DT8 was a very rare cause of human illness in Ireland between 2000 and 2008, with only four human isolates from three patients being identified. Over a 19-month period between August 2009 and February 2011, 34 confirmed cases and one probable case of Salmonella Typhimurium DT8 were detected, all of which had an MLVA pattern 2-10-NA-12-212 or a closely related pattern. The epidemiological investigations strongly supported a link between illness and exposure to duck eggs. Moreover, S. Typhimurium with an MLVA pattern indistinguishable (or closely related) to the isolates from human cases, was identified in 22 commercial and backyard duck flocks, twelve of which were linked with known human cases. A range of control measures were taken at farm level, and advice was provided to consumers on the hygienic handling and cooking of duck eggs. Although no definitive link was established with a concurrent duck egg-related outbreak of S. Typhimurium DT8 in the United Kingdom, it seems
Biovista Vizit is a visual exploration tool for biomedical literature based on NCBI PubMed. Vizit allows scientists to search and explore a biomedical domain, such as a disease, a pathway or a gene, and to create biomedical networks and graphs.
Question: Dear Moriel.org I have much appreciation and thanks for the service your site provides to the Church at large. I think your article opposing...
A unique collection of 1154 clinical compounds for high throughput screening (HTS) and high content screening (HCS). • Research areas include anticancer, anti-infection, anti inflammation, nervous disease, and more. • A useful tool for drug repurposing. • Currently in clinical stage, some are withdrawn or terminated. • Structurally diverse, medicinally active, and cell permeable. • Detailed compound information with structure, IC50, and brief introduction. • Validated NMR and HPLC to ensure high purity and quality. • All compounds are in stock and continuously updated. ...
Zamani M, Sharifi Tehrani A, Ali Abadi AA (2007). "Evaluation of antifungal activity of carbonate and bicarbonate salts alone or in combination with biocontrol agents in control of citrus green mold". Communications in Agricultural and Applied Biological Sciences. 72 (4): 773-7. PMID 18396809 ...
Preface xvi. Abacacavir (Ziagen) 435. Abacavir + Lamivudine + Dolutegravir (Triumeq) 381. Acyclovir (Zovirax) 442. Adefovir (Hepsera) 187. Albendazole (Albenza) 3. Amikacin (Amikin) 9. Amoxicillan 11. Amoxicillin-Clavulanate (Augmentin, Augmentin 600ES, Augmentin XR) 32. Amphotericin B (Fungizone) 169. Amphotericin B Colloidal Dispersion - ABCD (Amphotec) 13. Amphotericin B Lipid Complex (Abelcet) 1. Ampicillin 15. Ampicillin-Sulbactam (Unasyn) 394. Anidulafungin (Eraxis) 149. Artemether/Lumefantrine (Coartem) 92. Artesunate 27. Atazanavir (Reyataz) 317. Atazanavir + Cobicistat (Evotaz) 152. Atovaquone (Mepron) 240. Atovaquone/Proguanil (Malarone) 230. Azithromycin (Zithromax, Zmax) 437. Aztreonam (Azactam) 40. Bedaquiline (Sirturo) 337. Benznidazole 51. Bithionol (Bitin) 57. Capreomycin (Capastat) 62. Caspofungin (Cancidas) 60. Cefaclor 66. Cefadroxil (Duricef) 135. Cefamandole (Mandol) 232. Cefazolin (Ancef) 18. Cefdinir (Omnicef) 270. Cefditoren Pivoxil (Spectracef) 343. Cefepime (Maxipime) ...
Along the lines that have been discussed in a recent Frontiers short paper, here is a list of our patent discussions in the December 2017 drug repurposing special issue of ASSAY and Drug Development Technologies:. WO/2017/059389 (Kythera Biopharmaceuticals, USA): Statins as an alternative to liposuction and cryolipolysis. WO/2017/060308 (AB Science, France): Masitinib switches to human use. WO/2017/066421 (Ovid Therapeutics, USA): Eplivanserin for improving cognition in psychoses. WO/2017/068143 (Individual, Germany): BAY 11-7082 or dimethyl fumarate for adiposity or cardiovascular diseases. WO/2017/080919 (Freiburg University, Germany): Roflumilast for metabolic lipid disorders. WO/2017/081609 (Individuals): Febuxostat: from gout to neurology. WO/2017/085407 (Pierre et Marie Curie University et al., France): Mirabegron, an overactive bladder drug, for macular degeneration. WO/2017/091644 (AZ Therapies, USA): Cromolyn for cerebral ischemia and dementia. WO/2017/096013 (Cornell University, USA): ...
The platform for pet owners and breeders that contains all the important information at a glance. LABOKLIN has many years of experience with the implementation and development of genetic tests, particularly in the areas of genetic disorders, colour analysis, DNA profiles, ancestry and sex determination in birds. Our high quality standard is characterised particularly by the fact that all the results of our genetic studies are controlled in a second independent test run before they are shipped. ...
Noncyclical breast pain. This type of breast pain is not related to periods and is most common in women aged over 40. Pain can be present all the time, or come and go in a random way. The pain may be in just one breast, and may be localisedtoan area in breast .Reasonof this pain is unknown in most cases, however in few cases it might be due to,muscular or bony problems of the chest wall or Infection .Breast tumours, cancer are very rare cause of breast pain.The symptom of breast cancer is usually a painless lump. Pain is not usually an early symptom. As there are various causes it is best to see a doctor for assessment. What is the treatment for noncyclical breast pain?. NSAIDs such as ibuprofen may ease the pain. Topical NSAIDs may also work. Other treatments may be appropriate, depending on whether a cause is found.. ...
Hexachlorophene is a toxic chemical that induces edema, membrane damage, and increased sodium /decreased potassium in brain cells. (Hexachlorophene was used in shampoos, soaps and other personal care products until about a decade ago.) Rats were fed hexachlorophene orally for 3 weeks, then given Piracetam or one of 5 other drugs by injection for 6 days. Hexachlorophene seriously disrupted the rats ability to navigate a horizontal ladder without frequently falling off the rungs. Piracetam reduced the fall rate 75% compared to saline-injected controls on the first day of treatment. None of the other drugs came close to that improvement. (24). Piracetam increases the survival rate of rats subjected to severe hypoxia. (1,25) When mice, rats and rabbits have been put under diverse experimental hypoxic (low oxygen) conditions, Piracetam has acted to attenuate or reverse the hypoxia-induced amnesia and learning difficulties, while speeding up post-hypoxic recovery time and reducing time to renormalize ...
Steve Braun of Cures Within Reach, a nonprofit focused on breathing new life into old medicines, describes the potential benefits of drug repurposing.. 1 Comment. ...
Steve Braun of Cures Within Reach, a nonprofit focused on breathing new life into old medicines, describes the potential benefits of drug repurposing.. 1 Comment. ...
Urease is a nickel-dependent amidohydrolase that catalyses the decomposition of urea into carbamate and ammonia, a reaction that constitutes an important source of nitrogen for bacteria, fungi and plants. It is recognized as a potential antimicrobial target with an impact on medicine, agriculture, and the environment. The list of possible urease inhibitors is continuously increasing, with a special interest in those that interact with and block the flexible active site flap. We show that disulfiram inhibits urease in Citrullus vulgaris (CVU), following a non-competitive mechanism, and may be one of this kind of inhibitors. Disulfiram is a well-known thiol reagent that has been approved by the FDA for treatment of chronic alcoholism. We also found that other thiol reactive compounds (l-captopril and Bithionol) and quercetin inhibits CVU. These inhibitors protect the enzyme against its full inactivation by the thiol-specific reagent Aldrithiol (2,2′-dipyridyl disulphide, DPS), suggesting that the three
Abstract Between 1974 and 1985, 10 patients were studied who presented with either gastrointestinal complaints or unexplained peripheral blood eosinophilia, and had eggs typical for N. salmincola recovered from their stools. Clinical findings in 8 of the 10 included increased frequency of bowel movements or diarrhea (6), peripheral blood eosinophilia (6), abdominal discomfort (5), nausea and vomiting (3), weight loss (2), and fatigue (2). Two were asymptomatic. Eight recalled eating fish prior to the onset of symptoms. Anthelminthic treatment consisting of three 2-g doses of niclosamide (2 patients) or two 50 mg/kg doses of bithionol (1 patient) proved effective. In the remaining individuals symptoms resolved slowly over several months.
Findacure has found an innovative way to use this financial tool to fund drug repurposing research for rare diseases. This is the rare disease drug repurposing social impact bond - RDDR SIB for short.. But how would it work?. Our SIB is based on the premise that successfully repurposing low cost generic drugs for rare disease patients will save the NHS money. Rare diseases left untreated cost the NHS lots in surgery, care, appointments, hospital, stays, and much more - a cost that can be significantly reduced by a cheap, repurposed treatment. The NHS can then use a portion of these savings to reimburse Findacure for the cost of the clinical trial. We will use this reimbursement to pay back private investors, whose money was required to initially run the trial. Surplus reimbursement will be invested by us in more clinical trials: the project is self-sustaining and non-profit.. ...
Hexachlorophene is a broad spectrum anti-bacterial agent. It is used in hospital scrubs, shampoos, and deodorants. Once widely used in over-the-counter products, hexachlorophene is now prescription-only, after overdose incidents in infants in France in the 1970s. It has been largely replaced by the related compound Triclosan. ...
The virus is still found in tropical and subtropical areas in South America and Africa and remains a very rare cause of illness in U.S. travelers, according to CDC.
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CXCL7 (Human) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for quantitative detection of human CXCL7 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). (KA5605) - Products - Abnova
Comparative Studies on Some Biology and Pathology of Corn and Broom Corn Isolates of Exserohilum turcicum (Pass) Leonard & Suggs ...
Authors. Andrew K. Gonsalves, Educational Specialist. Stephen A. Ferreira, Extension Plant Pathologist. Department of Plant Pathology, College of Tropical and Agriculture and Human Resources. University of Hawaii at Manoa. PATHOGENS & HOSTS. Over four Exserohilum species have been reported to occur in Hawaii (Raabe, et al., 1981). The following is a list of the reported pathogens from this genus (Exserohilum) and the hosts they infect. The list is organized by the scientific name of the pathogen species (CAPITAL LETTERS), followed by the various susceptible plant hosts. Words in blue indicate what symptom or disease a given pathogen causes on the listed hosts.. EXSEROHILUM PEDICELLATUM. Leafspot:. corn, maize (Zea mays). EXSEROHILUM ROSTRATUM. Flower Fleck:. Dendrobium sp.. Seedling Blight:. sorghum (Sorghum bicolor). feterita (Sorghum caudatum). EXSEROHILUM SP.. Leafspot:. golden-fruited palm (Chrysalidocarpus lutescens). Manilla grass (Zoysia matrella). ?mascarene grass (Zoysia ...
Insilico Medicine will present its recent advances in applying deep learning techniques to drug discovery and repurposing at the Strategic Partnerships in Drug Repurposing conference in Boston taking place at the Wyndham Boston Beacon Hill Oct. 27-28.
6:30 pm Reception and Dinner and Remarks by APMRF. June 5, 2017 8:00 am Breakfast. Presentations. There will be opportunities to submit abstracts for talks and the poster session. All submissions are due by April 1, 2017.. Speakers include:. Keynote address by Dr. Thijn Brummelkamp, Genetic studies on the function of NPC1 in pathogen entry and cholesterol trafficking. Dr. Roberto Zonco, Mechanisms of cholesterol sensing by the master growth regulator mTORC1 kinase. Dr. Wei Zheng, Therapeutic development for treatment of NPC: beyond cyclodextrin. Dr. Arun Radikrishnan, Intracellular trafficking routes of cholesterol. Dr. Kenji Ohgane, Identification of Chaperone Drugs for NPC through Drug Repurposing Screening. Dr. Yiannis Loannou, Targeting the Mitochondria-ER-Lysosome axis for the treatment of multiple lysosomal storage diseases. Dr. Charles Vite, Gene therapy in the CNS in large animal models. Dr. Xuntian Jiang, Biomarker discovery and development of diagnostics for early detection of NPC ...
BIONEXT is a French biotechnology company dedicated to the better understanding and treatment of various diseases. BIONEXT aims to accelerate and improve the effectiveness of drug development and biological research by developping programs and software-based tools to tackle problematics of prime importance in the pharmaceutical field, such as drug profile assesment or suggestion of drug repurposing.
http://ift.tt/eA8V8J. The northern hemispheres summer is ending and that is definitely bad news. The good news is that this was not a silly season in health and healthcare research.. Heres the best and worst news of the summer.. The best. Drug repurposing screening reveals possible candidates for anti-Zika therapy. Developing a new drug is a long process, but the Zika virus outbreak has created a global health emergency and a pressing need for therapies that is incompatible with the timings of drug development. This led to a major study published in Nature Medicine in which over 6,000 compounds were screened for possible drug repurposing, including approved drugs, clinical trial drug candidates and pharmacologically active compounds. This screening allowed the identification of compounds that were able to inhibit Zika infection, suppress the effects of infection in neurons, or inhibit viral replication. Furthermore, combination treatments using neuroprotective and antiviral compounds showed a ...
The tapeworms described in this study were retrieved from a young male elephant that died at the Udawalawe Elephant Transit Home in Sri Lanka. Anoplocephala manubriata has very muscular suckers on its scolex which allows it to keep a firm grip on the host intestinal wall. But this is not so great for the elephant - the suction from the tapeworms suckers essentially end up leaving hickeys on the elephants intestinal mucosa, which is not a particularly healthy place for an elephant to get love bites, especially if they have been left there by a bunch of tapeworms. Indeed, the elephant that was necropsied in this study was found to have multiple lesions and ulcers on the gut lining as a result of these parasitic love bites. This tapeworm seems to be far more common among younger elephants than adults, possibly because older elephants have more developed immune systems, and have build up some kind of resistant towards these parasites ...
The tapeworms described in this study were retrieved from a young male elephant that died at the Udawalawe Elephant Transit Home in Sri Lanka. Anoplocephala manubriata has very muscular suckers on its scolex which allows it to keep a firm grip on the host intestinal wall. But this is not so great for the elephant - the suction from the tapeworms suckers essentially end up leaving hickeys on the elephants intestinal mucosa, which is not a particularly healthy place for an elephant to get love bites, especially if they have been left there by a bunch of tapeworms. Indeed, the elephant that was necropsied in this study was found to have multiple lesions and ulcers on the gut lining as a result of these parasitic love bites. This tapeworm seems to be far more common among younger elephants than adults, possibly because older elephants have more developed immune systems, and have build up some kind of resistant towards these parasites ...
Screening with magnetic resonance imaging identified 21% of patients with a spinal or paraspinal infection resulting from a tainted steroid injection, researchers reported in JAMA. A multistate outbreak of fungal meningitis that started in the fall of 2012 was linked to vials of methylprednisolone that were contaminated with Exserohilum rostratum at the New England Compounding Center. Besides
Macrophage inhibitory cytokine-1 (MIC-1) is a recently described divergent member of the transforming growth factor-ss superfamily. MIC-1 transcription up-regulation is associated with macrophage activation, and this observation led to its cloning. Northern blots indicate that MIC-1 is also present in human placenta. A sensitive sandwich enzyme-linked immunosorbent assay for the ...
Repurposing Drugs in Oncology (ReDO) project by the Anticancer Fund and GlobalCures reporting pre-clinical and clinical evidence for very promising candidates ...
Security researchers have unearthed a concerning vulnerability in Slack that allowed hackers to snatch your token and take control of your account.
Ho provato di aggiornare slackware64-14.0 a 14.1 su una macchina virtuale prima di aggiornare la slack su portatile pero probabilmente non ho configurato bene lilo, e non sono riuscito piu avviarla. Pero almeno ho capito cosa non e chiaro per me per aggiornare la slack a 14.1 su portatile ...
Yellow Fever is found in tropical and subtropical areas in South America and Africa. The virus is transmitted to humans by the bite of an infected mosquito. Yellow fever is a very rare cause of illness in U.S. travelers. Illness ranges in severity from a self-limited febrile illness to severe liver disease with bleeding. Yellow fever disease is diagnosed based on symptoms, physical findings, laboratory testing, and travel history, including the possibility of exposure to infected mosquitoes. There is no specific treatment for yellow fever; care is based on symptoms. Steps to prevent yellow fever virus infection include using insect repellent, wearing protective clothing, and getting vaccinated." - CDC.gov ...
Data are presented on the last 3 years of a 7-year study (1989-1995) on transmission of natural infections of internal parasites in horse foals (n = 27) born in 1993, 1994, and 1995 on the same pasture on a farm in central Kentucky. The foals were in a closed breeding herd of horses. Research on the first 4 years (1989-1992) of the study was published earlier (Lyons et al., 1991, 1994). Thirty-five species of endoparasites were identified, including 24 species of small strongyles. Monthly, seasonal, and host-age transmission patterns were elucidated for the parasites. Comparison of data between the first 4 years and last 3 years of the study indicates similarities, but also differences, including an increase in prevalence and numbers of Thelazia lacrymalis and Anoplocephala perfoliata.
Sandwich ELISA is a highly sensitive method that can be used to determine if two epitopes are part of the same macromolecule or supramolecular complex. In the case of plant cell wall glycans, it can reveal the existence of inter-polymers linkages, leading to better understanding of overall cell wall architectures. This development of a conventional sandwich ELISA protocol uses a carbohydrate-binding module (CBM), a small protein domain found in some carbohydrate catalysing or activating enzymes, and rat monoclonal antibodies (mAbs) which can be combined in the same ELISA plate without risk of cross reaction; the secondary anti-rat HRP antibody being only able to bind to the rat mAb and not the CBM. This protocol was developed and modified in the Prof. J. Paul Knox lab at the University of Leeds.
Miners lettuce flowers (Claytonia perfoliata). This edible plant is native to North America and was introduced to Europe in the 18th Century, where it has become invasive in some areas. It is edible, and was an important source of vitamin C for the California goldrush miners. Photographed in the USA. - Stock Image B640/1451
SOM Biotech (SOM), a leading drug repurposing company based in Barcelona, Spain , has determined and validated an entirely new usage for Nippon Chemiphars marketed hypertension
Hyaluronan (HA) is widely detected in biological samples and its concentration is most commonly determined by the use of a labeled specific HA binding protein (aggrecan G1-IGD-G2, HABP), employing membrane blotting and sandwich enzyme-linked immunosorbent assay (ELISA)-like methods. However, the detected signal intensity or the quantified value obtained by using these surface-based methods is related to the molecular mass (M) of HA, especially for HA in the low M range below ~150 kDa. At the same mass or mass concentration, higher M HA gives a higher signal than lower M HA. We have experimentally determined the quantitative relationship between the M of HA (in the range 20-150 kDa) and the relative signal intensity in comparison with a standard HA, in a sandwich ELISA-like assay. An M-dependent signal correction factor (SCF) was calculated and used to correct the signal intensity, so that the corrected concentration value would more accurately reflect the true HA concentration in solution. The ...
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Dwolla offers an integration with Slack to send notifications about specific events that happen within Dwollas ACH API to a businesss Slack workspace.
Lansoprazole is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease. Dexlansoprazole is an isomer of lansoprazole that has a similar spectrum of activity and toxicities. Lansoprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a reported, but very rare cause of clinically apparent liver injury.
1. Probably the most famous repurposing case is that of thalidomide. First used as a sedative in the 1950s thalidomide is infamous for causing birth defects in babies of women who were prescribed it to treat nausea whilst pregnant. It was, however, successfully and safely repurposed in 1998 to treat leprosy and in 2006 to treat the blood cancer multiple myeloma.. 2. Discovered in 1972 on Easter Island, rapamycin, also known as Sirolimus, is produced by a soil bacterium Streptomyces hygroscopicus. Its ability to suppress the immune system led to its original approved use to prevent rejection in organ transplantation in 1999. It has since been successfully repurposed to treat two rare diseases, autoimmune lymphoproliferative syndrome (ALPS) and lymphangioleiomyomatosis, a lung disease.. 3. Lomitapide was originally used to lower cholesterol and triglycerides. It went on to be approved in 2012 by the Food and Drug Administration (FDA) and in 2013 by the European Commission to treat patients with ...
Recycling and re-using things efficiently are simply part of the modern world, so it should come as no surprise that a similar approach is being used in the pharmaceutical industry. Its called "repurposing," and it involves taking an existing approved drug, which has demonstrated safety in the use for which it is approved, and re-directing it to a new, patented therapeutic application. Repurposing an existing drug lowers the developmental risks associated with typical new drug development, and usually means shorter development times, lower development costs and less safety risk. More than 30 per cent of drug approvals or launches represent drugs repurposed for new indications, reformulations or new combinations of existing drugs.. Paradigm Biopharmaceuticals Limited (PAR), which joined the Australian Securities Exchange in August 2015, is a specialist drug repurposing company, formed to re-configure a compound called pentosan polysulphate sodium (PPS) into new applications, starting with a ...
Our partner, a Hungarian start-up company has developed an advanced visualization, multi-layered databases, network analytical cloud-based software and webservice called Biomedical Information Navigator (BIN). This service has been developed to facilitate early drug target discovery and drug repurposing for pharma-related researchers, Contract Research Organizations, pharma companies.. ...
Join ASN and more than 13,000 other kidney professionals from across the globe at Kidney Week. The worlds premier nephrology meeting, Kidney Week provides participants exciting and challenging opportunities to exchange knowledge, learn the latest scientific and medical advances, and listen to engaging and provocative discussions with leading experts in the field.. ASN introduces a new Annual Meeting session type to the program. Translational Sessions include scientific research that is intended to update and/or translate to clinical practice for the care of patients with kidney disease. This years topics include the following: CKD and nutrition, graft injury, drug repurposing, glomerular genomics, diabetes, HIV, kidney tumors, iron metabolism, transport physiology and electrolyte disorders, potassium and blood pressure, as well as clinical trials and organ transplantation.. ...
Review request for mesos, Artem Harutyunyan, Joris Van Remoortere, Joseph Wu, and Klaus Ma. Bugs: MESOS-4124 https://issues.apache.org/jira/browse/MESOS-4124 Repository: mesos Description ------- Enabled slave get ALLOCATION_SLACK metrics. Diffs ----- src/slave/metrics.hpp 2c22de521309806d70f9bd124359756b5e4c75b4 src/slave/metrics.cpp 1b73121264de3ff6eabc8f620e5b4d5930ba5d43 src/slave/slave.hpp b7586ce42bfac9d9885a3eb8d82deb94680c236c src/slave/slave.cpp 9bd86e122c070cd072a54d4de8097f844bd95bb0 Diff: https://reviews.apache.org/r/41250/diff/ Testing ------- $ curl http://192.168.0.107:5051/metrics/snapshot; 2,/dev/null, jq . , grep alloc_slack slave/cpus_alloc_slack_revocable_percent: 0, slave/cpus_alloc_slack_revocable_total: 3, slave/cpus_alloc_slack_revocable_used: 0, slave/disk_alloc_slack_revocable_percent: 0, slave/disk_alloc_slack_revocable_total: 0, slave/disk_alloc_slack_revocable_used: 0, slave/mem_alloc_slack_revocable_percent: 0, ...
Low concentrations of hexachlorophene (HCP) inhibit a number of pyridine nucleotide-linked dehydrogenase enzymes. The I₅₀ HCP concentrations were 105 μM for pig heart isocitrate dehydrogenase (ICD), 65 μM for horse liver alcohol dehydrogenase, 39 μM for torula yeast glucose-6-phosphate dehydrogenase (G6PD), 6.0 μM for beef heart malate dehydrogenase, and 1.6 μM for bovine liver glutamate dehydrogenase (GDH) at the enzyme concentrations tested. HCP exhibited cooperative inhibition of these enzymes since the observed maximum interaction coefficient, n, between HCP binding sites ranged between 1.62 and 3.33 but it was not an allosteric effector as evidenced by Hill coefficients for the substrates of approximately 1.0 both in the absence and the presence of HCP. More detailed kinetic analysis showed that HCP in most cases exhibited mixed kinetics, giving average K[subscript i] values with G6PD of 16.6 μM for NADP⁺ and 18.2 μM for glucose -6- phosphate; with ICD of 171 µM for NADP⁺ ...
Purpose and hypothesis: Neuroinflammation exacerbate damage caused by initial trauma from spinal cord injury (SCI). Severity of neuroinflammation depends on integrity of the blood-spinal cord-barrier (BSCB), as a compromised BSCB enhances neuroinflammation by facilitating immune cell infiltration. By targeting neuroinflammation, immunosuppressants are used to treat SCI patients. However, as patients experience immune suppression, immunomodulation is more effective than immunosuppression. Human Immunoglobulin G (hIgG) is used in clinic as an immunomodulatory treatment for inflammatory disorders. Although we have shown that administration of hIgG (0.4g/kg) is beneficial after SCI, the optimal dose and mechanism of hIgG are unknown. It is hypothesized that hIgG stabilizes the BSCB; reducing leukocyte infiltration, yielding long-term functional recovery and tissue preservation ...
Purpose: Adrenocortical carcinoma (ACC) is a rare and aggressive cancer, and no current effective therapy is available for locally advanced and metastatic ACC. Drug repurposing is an emerging approach for identifying new indications for existing drugs, especially for rare cancers such as ACC. The objective of this study was to use quantitative high-throughput screening to identify agents with antineoplastic activity against ACC. Experimental Design: A screening of 4,292 compounds was performed on three ACC cell lines: BD140A, SW-13, and NCI-H295R. Results: Twenty-one active compounds were identified, with an efficacy of ,80% in all three cell lines. Of these, niclosamide showed higher efficacy and lower IC50 than established anti-ACC drugs. We then validated niclosamide-inhibited cellular proliferation in all three ACC cell lines. Next, we investigated the mechanism by which niclosamide inhibited ACC cell proliferation, and found that it induced caspase-dependent apoptosis and G1 cell cycle ...
Intended Use: This kit is used to assay the sample of Serum, blood plasma,Saliva, Urine, and other related tissue Liquid. Test principle The kit uses a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) to assay the level of Chicken...
Oncology drives you to some pretty strange ideas about therapy. But thats understandable - in what other field are you trying aggressively to kill off parts of the patients own body? Thats why chemotherapy started off with the study of people who had been exposed to mustard gas (during the Bari bombing raid), where
HPPI is currently planning to repurpose itraconazole, which is already approved as a treatment for fungal infections in other formulations, as a potential treatment for cancer.
NEW YORK, Feb. 13, 2018 /PRNewswire-iReach/ -- x.ai Launches AI Scheduling Assistants on Slack. Now you can use Amy + Andrew in your Slack channels and DMs.
Its been a while since we did this - and as we dont have a March challenge as yet (slack of me I know :p ) I thought this would be a good time. There is 117 days until the end of June - so this challenge will be until then (allowing for a - page 13
The two chemicals used are triclabendazole and bithionol. Ivermectin, which is widely used for many helminthic parasites, has ...
There are also reports of bithionol being used successfully. More recently, Mirazid, an Egyptian drug made from myrrh, has been ... Praziquantel is not effective, and older drugs such as bithionol are moderately effective but also cause more side effects. ... Fasciolicides (drugs against Fasciola spp.) fall into five main chemical groups: Halogenated phenols: bithionol (Bitin), ...
Drugs used to treat infestation include triclabendazole, praziquantel, bithionol, albendazole, levamisole and mebendazole. ...
The drug of choice to treat paragonimiasis is praziquantel, although bithionol may also be used. Drunken shrimp Haswell-Elkins ...
Other medications can also be used such as bithionol, niclofan, and triclabendazole with high cure rates. Thorough cooking of ...
To obtain the worms from the host, piperazine citrate, levamisole and bithionol can be administered to the patient. ...
Bithionol is an alternative drug for treatment of this disease but is associated with skin rashes and urticaria. For additional ...
... including bithionol, niclosamide, nicoflan, and Praziquantel. All drugs showed lower prevalence of eggs in feces, however only ...
ഹെക്സാക്ലോറോഫീൻ (Hexachlorophene), ബിഥിയോനോൾ (Bithionol) എന്നിവ ദുർഗന്ധനിവാരിണികൾക്ക് ഉദാഹരണങ്ങളാണ്. പൌഡറിലും പല്ലുതേയ്ക്കുന്ന ...
... unlike the previously used drug bithionol, which required extended treatment and involved more severe side effects. The latest ...
D10AA01 Fluorometholone D10AA02 Methylprednisolone D10AA03 Dexamethasone D10AB01 Bithionol D10AB02 Sulfur D10AB03 Tioxolone ...
... and can be eliminated from the body Three 2-g doses of niclosamide or two 50 mg/kg doses of bithionol have also proven to be ...
... bithionol (INN) bithionoloxide (INN) bitipazone (INN) bitolterol (INN) bitoscanate (INN) bivalirudin (INN) bivatuzumab ...
Example of such sodium salts are (selection): Bispyribac, bithionol, bosentan, brequinar, bromfenac, Cefmenoxime, ceftiofur, ...
... mucolytic compounds such as L-cysteine ethyl ester and the parasticide bithionol have been tested with some success although ...
On the other hand, there are other antihelminthic drugs available such as bithionol, thiabendazole, metronidazole, and others, ...
... fungicides benzohydroxamic acid benzothiazole fungicides bethoxazin binapacryl biphenyl bitertanol bithionol bixafen ...
QP52AG02 Hexachlorophene QP52AG03 Niclosamide QP52AG04 Resorantel QP52AG05 Rafoxanide QP52AG06 Oxyclozanide QP52AG07 Bithionol ...
P02BA01 Praziquantel P02BA02 Oxamniquine P02BB01 Metrifonate P02BX01 Bithionol P02BX02 Niridazole P02BX03 Stibophen P02BX04 ...
... has been shown to be a potent inhibitor of soluble adenylyl cyclase (sAC), an intracellular enzyme important in the ... Bithionol has two aromatic rings with a sulfur atom bonded between them and multiple chlorine ions and hydroxyl groups coming ... Bithionol is the first known sAC inhibitor to act through the bicarbonate binding site via a mostly allosteric mechanism. ... Bithionol is an anthelmintic used to treat Anoplocephala perfoliata (tapeworms) in horses and Fasciola hepatica (liver flukes ...
... is typically used to treat hypothyroidism,[9] and is the treatment of choice for people with hypothyroidism,[10] who often require lifelong thyroid hormone therapy.[11] It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.[12][13] Levothyroxine is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.[14] A subset of people with hypothyroidism treated with an appropriate dose of levothyroxine will describe continuing symptoms despite TSH levels in the normal range.[11] In these people, further laboratory and clinical evaluation is warranted as they may have another cause for their symptoms.[11] Furthermore, it is important to review their medications and possible dietary supplements as several medications can affect thyroid hormone levels.[11] Levothyroxine is also used to treat subclinical ...
In 2001, the German Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung, BfR) objected to the addition of isolated theanine to beverages.[39][40] The institute stated the amount of theanine consumed by regular drinkers of tea or coffee is virtually impossible to determine. While it was estimated the quantity of green tea consumed by the average Japanese tea drinker per day contains about 20 mg of the substance, there are no studies measuring the amount of theanine being extracted by typical preparation methods, or the percentage lost by discarding the first infusion. Therefore, with the Japanese being exposed to possibly much less than 20 mg per day, and Europeans presumably even less, it was the opinion of the BfR that pharmacological reactions to drinks typically containing 50 mg of theanine per 500 milliliters could not be excluded-reactions such as impairment of psychomotor skills and amplification of the sedating effects of alcohol and hypnotics.[41] In 2006, a study ...
The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestinal disorders at high exposure in test animals (just below LD50 level).[citation needed] Some reproductive disorders and decreasing weaning weight have been observed, also at high exposure. Effects on humans from use as a drug include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine occur.[citation needed] Carcinogenic effects have been shown at higher doses.[11] ...
GAD67 and GAD65 are also regulated differently post-translationally. Both GAD65 and GAD67 are regulated via phosphorylation of a dynamic catalytic loop,[10][11] but the regulation of these isoforms differs; GAD65 is activated by phosphorylation while GAD67 is inhibited by phosphorylation. GAD67 is predominantly found activated (~92%), whereas GAD65 is predominantly found inactivated (~72%).[12] GAD67 is phosphorylated at threonine 91 by protein kinase A (PKA), while GAD65 is phosphorylated, and therefore regulated by, protein kinase C (PKC). Both GAD67 and GAD65 are also regulated post-translationally by Pyridoxal 5'-phosphate (PLP); GAD is activated when bound to PLP and inactive when not bound to PLP.[12] Majority of GAD67 is bound to PLP at any given time, whereas GAD65 binds PLP when GABA is needed for neurotransmission.[12] This reflects the functional properties of the two isoforms; GAD67 must be active at all times for normal cellular functioning, and is therefore constantly activated by ...
InChI=1S/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+;25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m00/s1 ...
Bithionol has been shown to be a potent inhibitor of soluble adenylyl cyclase (sAC), an intracellular enzyme important in the ... Bithionol has two aromatic rings with a sulfur atom bonded between them and multiple chlorine ions and hydroxyl groups coming ... Bithionol is the first known sAC inhibitor to act through the bicarbonate binding site via a mostly allosteric mechanism. ... Bithionol is an anthelmintic used to treat Anoplocephala perfoliata (tapeworms) in horses and Fasciola hepatica (liver flukes ...
After two to five doses of bithionol, no Paragonimus eggs appeared in bloody sputum or in feces, and eosinophilia decreased to ... Bithionol was not effective in one observed case of clonorchiasis. ... Summary Bithionol in daily doses of 20 to 50 mg/kg given orally, on alternate days, was used in the treatment of 80 patients ... Bithionol in daily doses of 20 to 50 mg/kg given orally, on alternate days, was used in the treatment of 80 patients with ...
Abstract Bithionol-2,2′thiobis(4,6-bichlorphenol)-was used for the mass treatment of 1,355 patients with proved infections with ... Bithionol-2,2′thiobis(4,6-bichlorphenol)-was used for the mass treatment of 1,355 patients with proved infections with ...
The report generally describes bithionol sodium salt, examines its uses, production methods, patents. BITHIONOL SODIUM SALT ... Bithionol sodium salt prices in other regions. 7. BITHIONOL SODIUM SALT END-USE SECTOR 7.1. Bithionol sodium salt market by ... 6. BITHIONOL SODIUM SALT MARKET PRICES. 6.1. Bithionol sodium salt prices in Europe. 6.2. Bithionol sodium salt prices in Asia ... 2. BITHIONOL SODIUM SALT APPLICATIONS. 2.1. Bithionol sodium salt application spheres, downstream products. 3. BITHIONOL SODIUM ...
Initial treatment with bithionol failed. The patient was then treated with praziquantel 75 mg/kg body weight a day for 2 days ... Initial treatment with bithionol failed. The patient was then treated with praziquantel 75 mg/kg body weight a day for 2 days ... Successful Praziquantel Treatment of Paragonimiasis Following Bithionol Failure A Case Report* * Richard J. Johnson†, Steven B ...
Bithionol has been reported to cure over 90% of infected patients. We report a case of a 32-year-old Laotian man residing in ... He was successfully treated with a second course of bithionol (40 mg/kg by mouth every other day for 15 doses). The mechanism ... Connecticut who relapsed with P. westermani pneumonitis 4 months after apparent eradication of infection with bithionol (40 mg/ ... Abstract Clinical trials of bithionol in treating Paragonimus westermani lung infection have been conducted in areas of endemic ...
No serious side reactions to the bithionol were seen. Nausea, vomiting, and slight epigastric pain were each noted in one ... Summary Bithionol administered orally in a single dose of 50 to 66 mg/kg body weight to eight patients with Taenia saginata and ... Bithionol administered orally in a single dose of 50 to 66 mg/kg body weight to eight patients with Taenia saginata and eight ... Treatment of Taenia Saginata and Diphyllobothrium Latum Infections with Bithionol * Misao Nagahana, Yukio Yoshida, Kiroku ...
In this in vitro study, we evaluated the antitumor efficacy of cisplatin in combination with Bithionol (BT) against a panel of ... From: Evaluation of the cytotoxicity of the Bithionol - cisplatin combination in a panel of human ovarian cancer cell lines ...
Bithionol. Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and ... Bithionol. Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and ...
a) The prescription-dispensing requirements of section503(b)(1)(B) of the Federal Food, Drug, and Cosmetic Act are not necessary for the protection of the public health with respect to the following drugs subject to new drug applications: (1) N -Acetyl-p -aminophenol (acetaminophen, p -hydroxy-acetanilid) preparations meeting all the following conditions: (i) The N -acetyl-p -aminophenol is prepared, with or without other drugs, in tablet or other dosage form suitable for oral use in self-medication, and containing no drug limited to prescription sale under the provisions of section 503(b)(1) of the act. (ii) The N -acetyl-p -aminophenol and all other components of the preparation meet their professed standards of identity, strength, quality, and purity. (iii) If the preparation is a new drug, an application pursuant to section 505 (b) of the act is approved for it. (iv) The preparation contains not more than 0.325 gram (5 grains) of N -acetyl-p -aminophenol per dosage unit, or if it is in ...
ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:LOROTHIDOL, Synonyms:LOROTHIDOL , BITHIONOLATE SODIUM , BITHIONOL , ... D10AB01 - bithionol. P - ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS. P02 - ANTHELMINTICS. P02B - ANTITREMATODALS. ...
ii) Any ingredients labeled with any of the following or similar claims. Instant protection or protection immediately upon application. Claims for "all-day" protection or extended wear claims citing a specific number of hours of protection that is inconsistent with the directions for application in 21 CFR 201.327. (30) [Reserved] (b) Any OTC drug product that is labeled, represented, or promoted for the uses specified and containing any active ingredient(s) as specified in paragraph (a) of this section is regarded as a new drug within the meaning of section 210(p) of the Federal Food, Drug, and Cosmetic Act (the Act), for which an approved new drug application under section 505 of the Act and part 314 of this chapter is required for marketing. In the absence of an approved new drug application, such product is also misbranded under section 502 of the Act. (c) Clinical investigations designed to obtain evidence that any drug product labeled, represented, or promoted for the OTC uses and ...
Relapse of Paragonimus Westermani Lung Infection After Bithionol Therapy David L. Coleman and Michele Barry ... Bithionol has been reported to cure over 90% of infected patients. We report a case of a 32-year-old Laotian man residing in ... Clinical trials of bithionol in treating Paragonimus westermani lung infection have been conducted in areas of endemic ... He was successfully treated with a second course of bithionol (40 mg/kg by mouth every other day for 15 doses). The mechanism ...
Bithionol (Bitin) 57. Capreomycin (Capastat) 62. Caspofungin (Cancidas) 60. Cefaclor 66. Cefadroxil (Duricef) 135 ...
bithionol. *chlorofluorocarbon propellants. *chloroform. *halogenated salicylanilides, di-, tri-, metabromsalan and ...
Bithionol: All drug products containing bithionol.. Bromfenac sodium: All drug products containing bromfenac sodium (except ...
700.11 Cosmetics containing bithionol. (a) Bithionol has been used to some extent as an antibacterial agent in cosmetic ... It is, therefore, the view of the Food and Drug Administration that bithionol is a deleterious substance which may render any ... Accordingly, any cosmetic containing bithionol is deemed to be adulterated under section 601(a) of the Federal Food, Drug, and ... Also, there is evidence to indicate that bithionol may produce cross-sensitization with other commonly used chemicals such as ...
Study CHEMOTHERAPEUTIC DRUGS - ANTIPROTOZOAL AND ANTHELMINTIC DRUGS flashcards from Tiago Rodrigues
This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
Bithionol. Not Available. DB12035. Sarecycline. Sarecycline is a tetracycline-class drug indicated for the treatment of ...
Treatment with anthelminthics (praziquantel for most; bithionol, paromomycin, or sodium amidotrizoate and meglumine ...
... manufacturer factory of Veterinary APIs in India Animal or Veterinary products producer by Aarambh life science is Bithionol ...
  • We also found that other thiol reactive compounds ( l -captopril and Bithionol) and quercetin inhibits CVU. (mdpi.com)
  • Other potential in-feed treatments such as immunosupportive-based feeds, mucolytic compounds such as L-cysteine ethyl ester and the parasticide bithionol have been tested with some success although not developed for commercial use. (wikipedia.org)
  • They also synthesized new compounds, to learn more about how bithionol works and enhance its potential for clinical use. (blogspot.com)
  • Multidrug resistant malaria in children and adolescents with benign prostatic hypertrophy , a lower rate than expected, an ultrasound can provide visualization of the foot on the age group and related compounds: Phenol, cresol, chlorocresol, hexylre-sorcinol, bithionol, thymol, hexachlorophane, chlorhexidine. (bigsurlandtrust.org)
  • Bithionol has antibacterial and anthelmintic properties along with algaecide activity. (wikipedia.org)
  • Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity. (selleckchem.com)
  • While it was known that bithionol had some antibacterial activity, the results from this study indicate that it "is actually much more potent than what had been previously reported," says Meghan Blackledge , assistant professor of chemistry at High Point University, who researches treatments for MRSA. (wrkf.org)
  • Bithionol has been shown to be a potent inhibitor of soluble adenylyl cyclase (sAC), an intracellular enzyme important in the catalysis of ATP to cAMP. (wikipedia.org)
  • Based on its relationship to the organochlorine, hexachlorophene, which has been shown to be a successful, but isomer-specific inhibitor of soluble adenylyl cyclase, bithionol was chosen to study potential inhibitors of the sAC enzyme. (wikipedia.org)
  • The Arginine 176 usually interacts with the ATP and other catalytic ions at the active site, so when it turns from its normal position to interact with the bithionol inhibitor, it no longer functions in keeping the ATP bound to the active site. (wikipedia.org)
  • Bithionol is the first known sAC inhibitor to act through the bicarbonate binding site via a mostly allosteric mechanism. (wikipedia.org)
  • At normoxia, O XPHOS cell respiration was decreased down to ~15 and ~10% by the aminotransferase inhibitor aminooxyacetate (AOA) or with AOA plus the glutamate-dehydrogenase inhibitor bithionol, respectively. (frontiersin.org)
  • This translates to a decreased rate of reaction and a decreased affinity between substrates when bithionol is in higher concentrations. (wikipedia.org)
  • Unfortunately, in order for bithionol to potently inhibit the soluble adenylyl cyclase enzyme, it requires concentrations that are cytotoxic in vivo. (wikipedia.org)
  • Bithionol has two aromatic rings with a sulfur atom bonded between them and multiple chlorine ions and hydroxyl groups coming off of the phenyl groups. (wikipedia.org)
  • Evaluation of Marked Rise in Fecal Egg Output after Bithionol Administration to Horse and its Application as a Diagnostic Marker for Equine Anoplocephala perfoliata Infection" (pdf). (wikipedia.org)
  • Hence, the control was significantly higher than both bithionol treatments. (edu.au)
  • Following the freshwater bath, clinical signs of AGD recurred at a similar level across all treatments although controls clinical signs were significantly higher than the bithionol treatments to begin with. (edu.au)
  • Clinical trials of bithionol in treating Paragonimus westermani lung infection have been conducted in areas of endemic infection. (ajtmh.org)
  • Of these, several have vaccines and therapeutics must be evaluated for their advanced beyond pre-clinical studies in animals and en- efficacy in human trials, yet the design of efficacy trials tered phase 1 human trials [3, with two candidates and the appropriate selection of clinical endpoints pose a challenge. (deepdyve.com)
  • Other medications can also be used such as bithionol, niclofan, and triclabendazole with high cure rates. (wikipedia.org)
  • They found 185 drugs that passed this screen, but only a few of them, including bithionol, could penetrate the membrane of persister bacteria. (wrkf.org)
  • Using computer simulations, the scientists showed that bithionol could penetrate only the membranes of bacteria, not those of mammalian cells. (wrkf.org)
  • Of course, the danger of bacteria eventually becoming resistant to bithionol, too, is ever present. (anh-usa.org)
  • Palatability was not a problem with mean feed intake of bithionol over the trial duration higher compared to both the oil and plain controls. (edu.au)