Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.Jaw: Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Jaw DiseasesBisphosphonate-Associated Osteonecrosis of the Jaw: Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.Femur Head Necrosis: Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Femur Head: The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.Maxillary DiseasesOsteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Mandibular DiseasesBone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Jaw Neoplasms: Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.Tooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Bone Resorption: Bone loss due to osteoclastic activity.Humerus: Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Jaw Abnormalities: Congenital absence of or defects in structures of the jaw.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Hypercalcemia: Abnormally high level of calcium in the blood.Femoral Fractures: Fractures of the femur.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Fractures, Bone: Breaks in bones.Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Fractures, Stress: Fractures due to the strain caused by repetitive exercise. They are thought to arise from a combination of MUSCLE FATIGUE and bone failure, and occur in situations where BONE REMODELING predominates over repair. The most common sites of stress fractures are the METATARSUS; FIBULA; TIBIA; and FEMORAL NECK.Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.Osteocytes: Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.Bone Diseases: Diseases of BONES.Bone Transplantation: The grafting of bone from a donor site to a recipient site.Tooth Socket: A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.Tantalum: Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Fibula: The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.Hip Joint: The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.Teriparatide: A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)Geranyltranstransferase: An enzyme involved in the MEVALONATE pathway, it catalyses the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.Bone Diseases, MetabolicTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Metal-on-Metal Joint Prostheses: Types of prosthetic joints in which both wear surfaces of the joint coupling are metallic.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Hip Fractures: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).Osteoporotic Fractures: Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Decalcification Technique: Removal of minerals from bones during bone examination.Arthroplasty, Replacement, Hip: Replacement of the hip joint.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Masticatory Muscles: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)Dental Prophylaxis: Treatment for the prevention of periodontal diseases or other dental diseases by the cleaning of the teeth in the dental office using the procedures of DENTAL SCALING and DENTAL POLISHING. The treatment may include plaque detection, removal of supra- and subgingival plaque and calculus, application of caries-preventing agents, checking of restorations and prostheses and correcting overhanging margins and proximal contours of restorations, and checking for signs of food impaction.Osteotomy: The surgical cutting of a bone. (Dorland, 28th ed)Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Orthopedic Procedures: Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.Dromaiidae: A family of flightless, running BIRDS, in the order Casuariiformes. The emu is the only surviving member of the family. They naturally inhabit forests, open plains, and grasslands in Australia.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Blood Coagulation Disorders, Inherited: Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Epiphyses: The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.Osteoradionecrosis: Necrosis of bone following radiation injury.Femoral Neck Fractures: Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.Diaphyses: The shaft of long bones.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Arthralgia: Pain in the joint.Jaw, Edentulous: The total absence of teeth from either the mandible or the maxilla, but not both. Total absence of teeth from both is MOUTH, EDENTULOUS. Partial absence of teeth in either is JAW, EDENTULOUS, PARTIALLY.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Bone Demineralization, Pathologic: Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)Decompression, Surgical: A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)Osseointegration: The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).Pulsed Radiofrequency Treatment: The application, via IMPLANTED ELECTRODES, of short bursts of electrical energy in the radiofrequency range, interspersed with pauses in delivery of the current long enough to dissipate the generated heat and avoid heat-induced tissue necrosis.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Adrenal Cortex HormonesJaw Cysts: Saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also nonepithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst. True jaw cysts are classified as odontogenic or nonodontogenic.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Hip: The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur.Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Nitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.Hip Dislocation, Congenital: Congenital dislocation of the hip generally includes subluxation of the femoral head, acetabular dysplasia, and complete dislocation of the femoral head from the true acetabulum. This condition occurs in approximately 1 in 1000 live births and is more common in females than in males.Breast Neoplasms: Tumors or cancer of the human BREAST.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Oral Surgical Procedures: Surgical procedures used to treat disease, injuries, and defects of the oral and maxillofacial region.Ilium: The largest of three bones that make up each half of the pelvic girdle.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Drug Substitution: The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Hip Prosthesis: Replacement for a hip joint.Spinal Fractures: Broken bones in the vertebral column.Osteoarthritis, Hip: Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.Implants, Experimental: Artificial substitutes for body parts and materials inserted into organisms during experimental studies.Hardness Tests: A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Magnetic Field Therapy: The magnetic stimulation of specific target tissues or areas of the body for therapeutic purposes via the application of magnetic fields generated by MAGNETS or ELECTROMAGNETS.Range of Motion, Articular: The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.Masseter Muscle: A masticatory muscle whose action is closing the jaws.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Prosthesis Failure: Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.X-Ray Microtomography: X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.Jaw, Edentulous, Partially: Absence of teeth from a portion of the mandible and/or maxilla.Protein Prenylation: A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Arthroplasty: Surgical reconstruction of a joint to relieve pain or restore motion.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.

Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience. (1/45)

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Taking the lead: sharing best practice in intravenous bisphosphonate use in urological cancers. (2/45)

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CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma. (3/45)

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Extraction socket healing in rats treated with bisphosphonate: animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients. (4/45)

AIM: The aim of this study is to replicate both clinical and histological presentation of bisphosphonate induced osteonecrosis of the jaws (BONJ) in an animal model of the disease state. Successful recapitulation of a BONJ-like indication in an animal model will be useful for studying pathogenesis, as well as prevention and treatment strategies for BONJ. MATERIALS AND METHODS: Eighty (80) rats were prospectively and randomly divided into two groups; control group(40) and study group(40). All animals in study group, injected with a dose of 1 mg/kg dexamethasone (DX) subcutaneously on day 7, 14, or 21; and 1, 2, or 3 doses of 7.5 microg/kg zoledronic acid (ZA) subcutaneously administered to coincide with the last day of DX. Half of the animals from each group underwent extraction of the left mandibular molars and the remaining animals underwent extraction of the left maxillary molars under pentobarbital-induced general anesthesia. All animals were euthanized twenty-eight (28) days following tooth extractions. RESULTS: The amount of new bone trabecules as significantly decreased in bisphosphonate-dexamethasone (BP-DX) treated sockets. Difference between both groups was found statistically significant (p=0,0001). There's no foreign body reaction in sockets of both groups and no significance difference observed for fibrosis (p=0,306). The necrosis scores were significantly higher in BP-DX treated sockets (p=0,015). The inflamation scores were significantly higher for study group (p=0,0001). CONCLUSION: This study provides preliminary observations for the development of an animal model of BONJ. But we think that there is need for other studies have only BP treated group and larger study population.  (+info)

Bisphosphonate-related osteonecrosis of the jaws. (5/45)

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Antibiotic effects on bacterial profile in osteonecrosis of the jaw. (6/45)

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A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosis. (7/45)

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Use of cone-beam computerized tomography for evaluation of bisphosphonate-associated osteonecrosis of the jaws in an experimental rat model. (8/45)

BACKGROUND: Bisphosphonate-induced osteonecrosis of the jaw (BONJ) is a frequently reported complication. The aim of this study was to investigate the clinical and histopathological presentation of BONJ with the Hounsfield score and to evaluate the reliability of the score for determining necrosis in an animal model. MATERIAL/METHODS: Eighty rats were prospectively and randomly divided into two groups of 40 each: a control group and an experimental group. Half of the animals from each group underwent extraction of the left mandibular molars, and the other half underwent extraction of the left maxillary molars under pentobarbital-induced general anesthesia. All animals were euthanized 28 days after tooth extraction. Maxillae and mandibles were extracted, cone beam computed tomography (CBCT) was performed, and Hounsfield scores were evaluated. RESULTS: The Hounsfield scores of the experimental group were found to be compatible with chronic osteomyelitis and periosteal reactions. The Hounsfield scores of the control group were compatible with a healthy healing period. CONCLUSION: In light of these results, both cone beam computed tomography (CBCT) and the Hounsfield Units (HU) evaluations together are thought to be efficient in the diagnosis of BONJ.  (+info)

Introduction:Bisphosphonates (BPs) are powerful drugs that inhibit bone metabolism. Adverse side effects are rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). To date, research has primarily focused on the development and progression of BRONJ in cancer patients with bone metastasis, who have received high dosages of BPs intravenously. However, a potential dilemma may arise from a far larger cohort, namely the millions of osteoporosis patients on long-term oral BP therapy. Patients and methods:This current study assessed 470 cases of BRONJ diagnosed between 2004 and 2008 at eleven different European clinical centres and has resulted in the identification of a considerable cohort of osteoporosis patients suffering from BRONJ. Each patient was clinically examined and a detailed medical history was raised.Results:In total, 37/470 cases (7.8%) were associated with oral BP therapy due to osteoporosis. The majority (57%) of affected individuals did not have any risk
When treating a patient undergoing or having undergone BRONJ therapy:. - As a general dentist, I consider the duration of the Bisphopshonate therapy and the key factirs pertient to the route of administration prior to choosing to continue dental treatment. As well, I consider other systemic factors and use the information provided by American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaw-2009 Update Approved by the Board of Trustees January 2009.. - What to tell your patients? Prevention (importance of oral hygiene) and education: They need to know that if they are prescribed a new bisphosphonates medication for osteoporosis by their physician, they must try to get a dental consult, in conjunction with the physician soon enough. This will allow the two professionals to apply the necessary modifications prior to starting the medication in order to minimise any oral sequelae. Do not make any modifications to patients existing ...
require tooth extractions has been an ongoing area of controversy with little data to support current recommendations. The AAOMS Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaw, revised in 2009, recommended discontinuing oral bisphosphonates for 3 months prior to and 3 months following invasive dental surgery - systemic con- ditions permitting.1 However there is currently no evidence that interrupting bisphosphonate therapy alters the risk of ONJ in patients following tooth ex- traction. In 2011 the ADA Council on Scientific Af- fairs revised their prior recommendation of a drug holiday and suggested that patients receiving lower cumulative doses of bisphosphonate (,2 years) or denosumab may continue antiresorptive therapy during invasive dental treatment.125 An International ONJ Task Force recommended a drug holiday in patients at higher risk for developing ONJ, includ- ing those with greater cumulative bisphosphonate exposure (,4 years), and those with comorbid risk factors ...
The frequency of zoledronic acid single-agent use was 85.9% and 69.8% in group A and B, respectively. Median follow-up was 13 months (group A) and 16 months (group B). Two patients in group A developed BRONJ (2%). Of those with BRONJ in group B who completed follow-up, healing occurred in 14.9% (7/47) and pain subsided in 80.9% (38/47). Healing was significant in patients who received pamidronate followed by zoledronic acid (P = .023) and with BRONJ stages 0 and stage I (P = .003 ...
TY - JOUR. T1 - Adjuvant denosumab in early breast-cancer. AU - Campisi, Giuseppina. AU - Bedogni, Alberto. AU - Fusco, Vittorio. PY - 2020. Y1 - 2020. N2 - We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).. AB - We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are ...
Other terminologies used previously include "denosumab related osteonecrosis of the jaw" (DRONJ), and "antiresorptive agent-induced ONJ" (ARONJ).. The aetiopathogenesis of MRONJ related to denosumab therapy remains enigmatic, and hypotheses have focused on reduced bony turnover, infection, toxicity of the soft tissue, and antiangiogenesis. The epidemiology also remains unclear, and reported incidence varies widely.6 Overall, it is estimated that bone necrosis can develop in about 0.7-1.9% of patients with malignancy who are given high-potency IV BPs (such as zoledronic acid), and in 0.01-0.1% of those with osteoporosis who take low-potency oral BPs (such as alendronate). Data relevant to denosumab given subcutaneously in patients with metastatic cancer and osteoporosis seem to replicate those when IV high-potency BPs are administered.7 The risk of osteonecrosis of the jaw (ONJ) is higher in patients exposed to concomitant antiagiogenic medication. The individuals risk of ONJ is further ...
Microbeads: the conversation continues On August 13th, in collaboration with Procter & Gamble, we published a post dealing with the safety of microbeads found in toothpaste. We received numerous interesting and important comments to the post; and despite reasurances that these are safe particles (by Health Canada), many dentists are still questioning the use of these microbeads: "I have been finding these specs of blue plastic stuck in my patients periodontal pockets and embedded in their gingiva. Even if they are inert, having these particles embedded in soft tissue could cause inflammation and irritation. It is possible to assume if they are embedding in the mouth they also embed in the folds of the digestive tract. Therefore, I have been advising patients to avoid toothpastes with these ingredients. I am interested to hear if others have had similar findings." What is your take on the issue? Share your opinion with us. Email us at [email protected] ...
The oral cavity is perhaps one of the most sensitive area of the body , and experiencing a tooth ache can be all-consuming. We strive to provide quick responses to tooth pain in scheduling and treatment. The proper treatment is likely to involve a root canal procedure which de-vitalizes the tooth and brings relief. ...
Bisphosphonate-associated osteonecrosis of the jaw (BON, BONJ) is death of the jawbone in a person with a history of bisphosphonate use who undergoes subsequent dental surgery. It may lead to surgical complication in the form of impaired wound healing following oral and maxillofacial surgery, periodontal surgery, or endodontic therapy. An association between history of bisphosphonate use and osteonecrosis of the jaw after later surgery was detected for several years and its cause is still not entirely clear. BON has been nicknamed "bis-phossy jaw" based on its similarity with phossy jaw. There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. Avoiding the use of bisphosphonates is not a viable preventive strategy on a general-population basis because the medications are beneficial in the treatment and prevention of osteoporosis (including prevention of bony fractures) and treatment of bone cancers. Osteonecrosis, or localized death of bone tissue, of the jaws is a ...
Background: Bisphosphonate-associated osteonecrosis of the jaws (MRONJ/BP-ONJ/BRONJ) is a commonly seen disease. During recent decades, major advances in diagnostics have occurred. Once the clinical picture shows typical MRONJ features, imaging is necessary to determine the size of the lesion. Exposed bone is not always painful, therefore a thorough clinical examination and radiological imaging are essential when MRONJ is suspected. Methods: In this paper we will present the latest clinical update on the imaging options in regard to MRONJ: X-ray/Panoramic Radiograph, Cone Beam Computed Tomography (CBCT) and Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Nuclear Imaging, Fluorescence-Guided Bone Resection. Conclusion: Which image modality is chosen depends not only on the surgeons/practitioners preference but also on the available imaging modalities. A three-dimensional imaging modality is desirable, and in severe cases necessary, for extended resections and planning of reconstruction.
Cancer Treat Rev. 2007 Feb;33(1):58-63. Bache M, Holzapfel D, Kappler M, Holzhausen HJ, Taubert H, Dunst J, Hänsgen G (2007) Survivin protein expression and hypoxia in advanced cervical carcinoma of patients treated by radiotherapy. GYNECOL ONCOL, 104: 139-44. Bloching M, Reich W, Schubert J, Grummt T, Sandner A (2007) The influence of oral hygiene on salivary quality in the Ames Test, as a marker for genotoxic effects. ORAL ONCOL, 43: 933-9. Bock JJ, Maurer P, Fuhrmann RA (2007) The importance of temporomandibular function for patient satisfaction following orthognathic surgery. J OROFAC ORTHOP, 68: 299-307. Böhnke A, Jung J, Taubert H, Hauptmann S, Bartel F (2007) [Both somatic and germline genetics of the TP53-pathway influence ovarian cancer incidence and survival]. Verh Dtsch Ges Pathol, 91: 233-42. Eckert AW, Maurer P, Meyer L, Kriwalsky MS, Rohrberg R, Schneider D, Bilkenroth U, Schubert J (2007) Bisphosphonate-related jaw necrosis--severe complication in maxillofacial surgery. CANCER ...
Cancer Treat Rev. 2007 Feb;33(1):58-63. Bache M, Holzapfel D, Kappler M, Holzhausen HJ, Taubert H, Dunst J, Hänsgen G (2007) Survivin protein expression and hypoxia in advanced cervical carcinoma of patients treated by radiotherapy. GYNECOL ONCOL, 104: 139-44. Bloching M, Reich W, Schubert J, Grummt T, Sandner A (2007) The influence of oral hygiene on salivary quality in the Ames Test, as a marker for genotoxic effects. ORAL ONCOL, 43: 933-9. Bock JJ, Maurer P, Fuhrmann RA (2007) The importance of temporomandibular function for patient satisfaction following orthognathic surgery. J OROFAC ORTHOP, 68: 299-307. Böhnke A, Jung J, Taubert H, Hauptmann S, Bartel F (2007) [Both somatic and germline genetics of the TP53-pathway influence ovarian cancer incidence and survival]. Verh Dtsch Ges Pathol, 91: 233-42. Eckert AW, Maurer P, Meyer L, Kriwalsky MS, Rohrberg R, Schneider D, Bilkenroth U, Schubert J (2007) Bisphosphonate-related jaw necrosis--severe complication in maxillofacial surgery. CANCER ...
Osteonecrosis is caused by the loss of blood supply to the bone. Without blood, the bone tissue dies, causing the bone to break down and collapse.. In people with healthy bones, the body makes new bone to replace old or injured bones. This process takes place during normal growth and after an injury to keep the bones strong. If you have osteonecrosis, your bone breaks down faster than your body can make enough new bone.. The prognosis for people with osteonecrosis varies from person to person. It depends on what part of the bone is affected by osteonecrosis, how much of the bone is affected, and how well the bone rebuilds itself.. Most people with osteonecrosis require treatment to prevent further bone damage, protect the bones and joints, and improve the use of joints with osteonecrosis.. Without treatment, the disease worsens and bone and joints break down and most people with the disease will have severe pain and limited movement within two years. ...
This is an official publication of data that had been reported previously at science conferences. The authors report a high rate of symptomless osteonecrosis as measured by MRI in HIV+ persons. But the authors conclude they cannot determine if this high rate is due to HIV or by some of the drugs taken and intense bodybuilding exercises performed by some of the study participants who had HIV infection. Osteonecrosis was more frequent among the HIV-infected persons who had used steroids, lipid-lowering drugs, or testosterone and among those who routinely did bodybuilding exercises. None of the adults without HIV infection were found to have osteonecrosis. Although this study did not involve patients with hip pain, osteonecrosis should probably be considered in HIV-infected persons who begin to have pain and problems with their hips ...
Hip osteonecrosis is really a serious condition characterised with a temporary or permanent disruption from the bloodstream supply towards the hip bone. Bone cells also require sufficient perfusion of oxygenated bloodstream because they are full of soft tissue known as marrow. Your bones are believed to get about 10 % from the bloodstream the heart pumps out, which enables for the bones to heal when broken, promote bone growth, in addition to allow removing metabolic waste material.. Osteonecrosis from the hip is really a gradual disorder that induce discomfort once the bloodstream supply towards the bone is disrupted. Its believed which more than 20,000 individuals the U . s . States are accepted towards the hospital every year for hip osteonecrosis treatment. The problem happens in individuals of every age group, races, or genders.. ...
If youve been reading up on the side effects of osteoporosis medications, you have undoubtedly heard about osteonecrosis of the jaw, and osteonecrosis and Fosamax in particular. In fact, some
Is Osteonecrosis a common side effect of Solupred? View Osteonecrosis Solupred side effect risks. Female, 74 years of age, weighting 138.9 lb, was diagnosed with multiple myeloma and took Solupred . Patient was hospitalized.
What Is Osteonecrosis? Bone is a living, growing material. It has a framework of protein. Calcium strengthens the bone framework. The outer layer of bone ...
La osteonecrosis, también denominada necrosis avascular o aséptica, es la muerte de las células óseas debido a una disminución del flujo sanguíneo.
Peter A. Huijbregts, PT, OCS, FAAOMPT. Abstract: Osteonecrosis of the humeral head may be idiopathic, but it is also associated with a number of known medical conditions. In these patient groups, it is a differential diagnostic possibility that the physical therapist needs to consider. This article discusses histopathology, classification, etiology, history and examination findings, and treatment of humeral head osteonecrosis. It also presents two case studies of patients with undiagnosed osteonecrosis who were referred to physical therapy to illustrate the difficulties and possibilities for correct identification of such patients.. Key Words: Osteonecrosis, Humeral head, Bone. Osteonecrosis is defined as the in situ death of cells within the bone due to a lack of circulation and not as a direct result of disease1,2. The cells involved may include osteocytes, both in cortical and cancellous bone, and hematopoietic and fat cells in the marrow cavity1. Osteonecrosis is also often referred to as ...
Arthritis. Literally means joint inflammation. It is a general term for more than 100 of the rheumatic diseases. Arthritis causes joint swelling, pain, and stiffness. Arthroplasty. Another name for total joint replacement. A procedure in which a damaged joint is surgically removed and replaced with an artificial prosthesis. It is the treatment of choice for osteonecrosis when the joint is destroyed. Asceptic necrosis. See osteonecrosis. Autoimmune disease. A disease that results when the immune system mistakenly attacks the bodys own tissues. Avascular necrosis. See osteonecrosis. Biopsy. A procedure in which tissue is removed from the body and studied under a microscope. A bone biopsy is a conclusive way to diagnose osteonecrosis. Blood vessels. Arteries, veins, and capillaries that carry blood through the body. Bone graft. The transplantation of healthy bone from one part of the body to replace injured or diseased bone in another part of the body. Bone morphogenic protein. A protein extracted ...
Symptoms vary depending on the type of osteonecrosis. Spontaneous osteonecrosis typically causes the sudden onset of pain. This pain may be most noticeable during episodes of increased activity. It may occur when bearing weight or when climbing stairs. Pain may also occur at night. Secondary osteonecrosis is often associated with chronic, deep-rooted pain. Both types of osteonecrosis can limit the mobility of the knee joint. ...
Activist Post. How often does your dentist insist on you giving you a dental X-ray just to make sure all is well? While a dental x-ray may be justifiable if there is some serious risk, research is pointing out that too many of these X-rays may result in a twofold risk increase in a brain cancer known as meningioma.. For the research, Elizabeth B. Claus, MD, PhD, of Yale University, and colleagues examined the records of 1,433 patients who were diagnosed with meningioma between May 2006 and April 2011. The researchers made a control group matched for sex, age, and geography.. Researchers found that bitewing X-rays (showing upper and lower back teeth) performed less than once per year was associated with patients being 1.1 to 1.6 times more likely to experience meningioma across age groups.. They also found that annual or more frequent panorex dental X-ray (an X-ray showing all teeth and surrounding bones) exposure increased odds by 2.7 to 3.0 in 3 of the oldest age groups, while x-rays performed ...
... Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Osteonecrosis - Pipeline Review, - Market research report and industry analysis - 11296578
Visit us to discover how to reduce your risk of getting osteonecrosis of the jaw, periodontal diseases, and the treatments for osteonecrosis.
Osteonecrosis of the jaw (ONJ) is a rare condition, the cause of which is not entirely known. It involves the loss or breakdown of a small segment of the jaw bone.
Its been several weeks since I last posted. It wasnt that I had forgotten about my site, I just wanted to take a moment to step back and live in the now. I have spent all my life either dwelling on the past or worrying about the future. One of the valuable lessons I have…
In light of recent reports of osteonecrosis of the jaw (ONJ) in cancer patients whose treatment regimens include an intravenous bisphosphonate, Novartis convened an international advisory board of experts in the fields of oral surgery and pathology, medical oncology, metabolic bone disease, and orthopedics to review existing data and provide updated recommendations on the clinical diagnosis, prevention, and management of ONJ in the oncology setting. Recommendations were developed to help guide healthcare professionals in early diagnosis and patient management. It is recommended that patients be encouraged to receive a dental examination prior to initiating bisphosphonate therapy and, if possible, complete any necessary dental procedures (e.g., tooth extraction) prior to initiating bisphosphonate therapy. Patients should receive regular dental visits during bisphosphonate therapy. Patients should be encouraged to practice good oral hygiene and minimize possible jaw trauma. If possible, patients ...
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Tooth extraction bleeding won t stop - Had a lower front tooth extraction and it wont stop bleeding. Help? Pressure. Place sterile gauze in the socket and apply firm pressure for 15 minutes. Repeat if necessary. If it continues after that, call your dentist.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Clinical Studies of Bisphoshonate Therapy and Osteonecrosis of the Jaws (R21) PAR-06-556. NIDCR
Osteonecrosis (Avascular Necrosis) is marked by a loss of blood supply to the bones, causing bone to break down faster than the body make new bone.
Men are much more prone to osteonecrosis ― a disease resulting from the loss of blood supply to the bones ― than women in South Korea, according to a study organized by the nations Health Insurance Service. According to the researchers, Korean men are 1.7 times more likely to develop the disease, which eventually causes the bone to break down, than Korean women. The number of patients with the illness has been on...
Physical therapy may be useful during the early stages of osteonecrosis. The goal of physical therapy is to preserve function, reduce further damage to the bone, and treat pain.
Osteonecrosis - Pipeline Review, H2 2015 is a market research report available at US $2000 for a Single User PDF License from RnR Market Research Reports Library.
The treatment process for osteonecrosis of the knee includes pain medication, use of a brace, exercises and activity modifications in the early stages, according to OrthoInfo. In more advanced...
A U.S. Food and Drug Administration advisory committee wants the agency to limit the duration of bisphosphonate therapy for treatment of osteoporosis, but the committee could not agree on what that time limit should be.
Osteonecrosis of the jaw (ONJ) is an emerging condition that has been associated with bisphosphonate use, typically in the context of cancer treatment. Currentl...
Having teeth extracted causes pain and costs money. Is your tooth extraction really necessary? We offer details on causes for extraction
Having teeth extracted causes pain and costs money. Is your tooth extraction really necessary? We offer details on causes for extraction
Tooth extractions in Glendale AZ may be necessary to remove broken or infected teeth, or teeth which have not erupted. Glendale (623) 915-9700 or Phoenix (602) 978-1932
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If you have a tooth that needs to be remove call us at 570-505-6908 for Tooth Extractions and Removal South WIlliamsport, PA and 620-228-4366 for Collegeville, PA
Our team may determine that you need a tooth extraction for any number of reasons. Some teeth are extracted because they are severely decayed; others...
You and Dr. Mercill may determine that you need a tooth extraction for any number of reasons. Some teeth are extracted because they are severely decayed; others
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The COMET Initiative brings together researchers interested in the development and application of agreed standardised sets of outcomes, known as a core outcome set.
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Hi all, Well had my first minor bleeding episode that landed me in the ER last night. Yesterday morning at about 9:30 had a tooth surgically removed under...
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How to Care for a Broken Jaw. Experts agree you need immediate medical treatment for a broken jaw since it can cause bleeding or even interfere with your breathing. A broken jaw occurs when you have a fracture in your jaw bone, often...
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Like all developing technologies, CBCT-image-guided implant surgery has evolved through several generations of the imaging and fabrication processes. The first guides were designed to be placed on bone and fabricated using stereolithography (3D) printing technology. An early comprehensive report on this approach by van Steenberghe et al2 evaluated edentulous patients receiving multiple implants with an immediate loading protocol.. Conventional implant surgery has almost always included exposing the implant site with an incision and flap. Yet, with the additional 3D information about the architecture of the underlying bone, it has been one of the alluring aspects of guided surgery to avoid an incision and flap. This means the guide is placed and held on soft tissue, osteotomies are performed and implants placed with a guide that is based on the CBCT plan. One of the first studies of flapless image-guided surgery was by Merli et al,3 whose team avoided flap and bone exposure by using a ...
December 28, 2017. The US Food and Drug Administration (FDA) has approved the marketing of the Dermapace System for adult patients with diabetic foot ulcers. This device is approved to treat chronic, full-thickness diabetic foot ulcers ≤16 cm2 that do not involve bone exposure. The Dermapace System mechanically stimulates foot ulcers via the use of energy pulses, similar to sound waves. In 2 double-blind, randomized, multicenter studies, 44% of patients treated with Dermapace experienced wound closure at 24 weeks, compared with 30% of patients who received sham treatment. Follow this link to read the full FDA News Release. ...
Bisphosphonates are becoming more widespread as indications for them broaden. Several ocular side effects due to bisphosphonates have been described, among the most potentially serious of which is orbital inflammation. Thirteen case reports of this s
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Cancer and its treatment can come with a variety of complications, some more serious than others.. What Is Osteonecrosis of the Jaw?. Osteonecrosis of the jaw (ONJ) is a severe bone disease that occurs when the jawbone is exposed and begins to starve from lack of blood. In short, the bone begins to weaken and die. The condition is characterized by an intraoral lesion of exposed bone that lasts for 8 weeks or more. The lesion may be accompanied by pain, inflammation of surrounding soft tissue, secondary infection, and drainage.. What Causes ONJ?. There is no certainty as to what causes ONJ; however, the condition is associated with cancer treatment, infection, steroid use, and the use of antiresorptive agents, which are drugs that help prevent bone loss. ONJ can also occur without any identifiable risk factors.. Though the exact cause of ONJ is unknown, researchers have speculated that it could be related to a decrease in blood vessel formation, the effects of infection, or a decrease in the ...
Tooth Extractions A visit to the dentist has always been perceived as a possibly painful experience. The probability of needing certain dental procedures such as tooth extractions and root canals has deterred many from seeking the proper dental care that is needed. Tooth extractions can be a tolerable process if it is
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Day 26 WEGO Health Writers Monthly Challenge #HAWMC I just wrote a booklet for this reason I will share some of it with you. Booklet Copyright 2016 Debla Some AVN Lingo THR Total Hip Replacement TKR Total Knee Replacement AVN Avascular Necrosis ON Osteonecrosis ONJ Osteonecrosis Jaw PT Physical Therapy OT Occupational Therapy AP Acute…
From the clinical perspective, the study design and the ensuing LOE classification may not always be the most important factor to consider while assessing the available evidence. Occasionally, even a well conducted RCT may not necessarily generate new knowledge superior to the knowledge gained from a case series study. Thus an RCT may be less significant to the clinical decision making than a case series study. For example, when a clinician assesses the benefits and risks of a possible treatment modality, the use of LOE alone can be misleading. An historical example is the use of Bisphosphonates for dental purposes:. Bisphosphonates (BPs) are a class of drugs that inhibit bone resorption and they are successfully used across a wide range of medical disciplines for bone diseases (Molvik & Khan 2015; Costa 2014; Anagha & Sen 2014; Giusti 2014; Bhatt et al. 2014; Eriksen et al. 2014). However, like any drug, BPs possess the risk of side effects. BPs-related osteonecrosis of the jaw (BRONJ) has been ...
Several risk factors for the development of osteonecrosis of the femoral head following treatment of developmental dislocated hip have been reported. The need for further research with a large-enough sample size including statistical adjustment of confounders was demanded. The purpose of the present study was to find reliable predictors of osteonecrosis in patients managed for developmental dislocation of the hip and to evaluate if delayed treatment increased the risk of residual acetabular dysplasia requiring secondary surgeries ...
Several risk factors for the development of osteonecrosis of the femoral head following treatment of developmental dislocated hip have been reported. The need for further research with a large-enough sample size including statistical adjustment of confounders was demanded. The purpose of the present study was to find reliable predictors of osteonecrosis in patients managed for developmental dislocation of the hip and to evaluate if delayed treatment increased the risk of residual acetabular dysplasia requiring secondary surgeries ...
Tooth extraction is when a tooth is removed from its place in the gum & bone of your jaw. Compared to many dental procedures, tooth extraction can sound scary, especially when its referred to as
Will your cheek really sink in after tooth extractions - Will your cheek really sink in after tooth extractions? It is possible. The presence and/or absence of teeth can definitely have an influence on the support of the lips and lower facial third. An individual who has all of his or her teeth removed without replacement can and will likely have the appearance of loss of fullness of the cheek and lips.
Pasadena TX Dentist Dr. Robson performs tooth extractions when the tooth is too damaged or decayed. For tooth extractions please call 281-487-8420
Dr. Jenista is highly skilled and experienced in performing wisdom teeth extractions and other types of teeth extractions. For this reason, many other dentists refer their patients to us for extractions, and Dr. Jenista is frequently complimented on his ...
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Start Over You searched for: Languages English ✖Remove constraint Languages: English Subjects Tooth Extraction ✖Remove constraint Subjects: Tooth Extraction Dates by Range 1950-1999 ✖Remove constraint Dates by Range: 1950-1999 ...
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Objetivo. Evaluar la efectividad de un programa de educación para la salud sobre el conocimiento y modificación de los factores de riesgo de aparición de osteonecrosis maxilar en pacientes tratados con bisfosfonatos.. Método. Estudio experimental del tipo «grupo control sin intervención», con 60 pacientes que iniciaron tratamiento con bisfosfonatos en el Hospital Universitario de León de octubre a diciembre de 2014. Los pacientes pertenecientes al grupo experimental recibieron una intervención educativa estructurada en dos sesiones. La recogida de datos se llevó a cabo mediante un cuestionario heteroadministrado, al inicio y al final del período de estudio, para ambos grupos.. Resultados. La intervención educativa diseñada mejoró significativamente la práctica de medidas básicas de higiene oral, como el control mecánico de la placa y el uso de clorhexidina previa a procedimientos orales invasivos. Ningún paciente declaró haber sido advertido de la necesidad de poner su boca en ...
Alberto Consolaro. The use of bisphosphonates induces clinicians to fear and care. hese reactions are associated with controversy resulting from lack of deep knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. here is no scientiic evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and maxillary osteomyelitis. heir use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or experiment trials with failing methods. Additional studies will always be necessary. However, deep knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications. Keywords: Bisphosphonates. Osteomyelitis. Osteonecrosis. Implants.. How to cite: Consolaro A. Bisphosphonates: opinion or scientific-based ...
Avascular necrosis, also referred as osteonecrosis treatment, is offered by orthopaedic surgeon Dr Roderick Brooks in Wahroonga, Sydney, NSW. Avascular necrosis is a condition in which bone death occurs because of inadequate blood supply to it.
Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg 2004;62:527 ... Bisphosphonate-related Osteonecrosis of the Jaws. Compendium 2008;29(2):97-105. Ju, H, et al. Comparison of analytical ... In order to evaluate the risk of osteonecrosis for a patient taking bisphosphonates, use of the CTX biomarker was introduced in ... Oral Bisphosphonate-Induced Osteonecrosis: Risk Factors, Prediction of Risk Using Serum CTX Testing, Prevention, and Treatment ...
Dannemann, C; Grätz, Kw; Riener, Mo; Zwahlen, Ra (Apr 2007). "Jaw osteonecrosis related to bisphosphonate therapy: a severe ... Bisphosphonates are associated with osteonecrosis of the mandible. Prolonged, repeated exposure to high pressures (as ... Underwater diving portal Osteonecrosis / Avascular Necrosis at the National Institute of Health Osteonecrosis / Avascular ... Bisphosphonates which reduces the rate of bone breakdown may prevent collapse (specifically of the hip) due to AVN. Other ...
"Interventions for treating osteonecrosis of the jaw bones associated with bisphosphonates". Reviews. doi:10.1002/14651858. ... Osteonecrosis of the jaws refers to the death of bone marrow in the maxilla or the mandible due to inadequate blood supply. It ... The term NICO is used to describe pain caused by ischemic osteonecrosis of the jaws, where degenerative extracellular cystic ... "Neuralgia-inducing cavitational osteonecrosis"[edit]. Neuralgia-inducing cavitational osteonecrosis (NICO) is a controversial ...
2007). "Bisphosphonate associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral ... A recognized risk of this drug relevant to dental treatments is bisphosphonate-associated osteonecrosis of the jaw (BRONJ). ... bisphosphonates and osteonecrosis of the jaws". Ann Intern Med. 144: 753-761. CS1 maint: Multiple names: authors list (link) ... Bisphosphonates have recently been introduced to treat several bone disorders, which include osteogenesis imperfecta. ...
... and osteonecrosis of the jaw. Use during pregnancy may result in harm to the baby. It is in the bisphosphonate family of ...
... because they have been associated with a disorder called Bisphosphonate-associated osteonecrosis of the jaw (BRONJ). The drugs ... "American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws-2009 ... procedures on the lower jaw, people with other medical issues, those on steroids, those on more potent bisphosphonates and ... the local health condition of the mucous membranes and the jaws and the shape, size, and position of the bones of the jaws, ...
... can also be associated with the radiographic changes seen in those with bisphosphonate-related osteonecrosis of the jaw. There ...
Identification of the relationship between intravenous bisphosphonate use and osteonecrosis of the jaw (Ana Hoff and Robert F ...
Osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including ... Zarychanski R, Elphee E, Walton P, Johnston J (2006). "Osteonecrosis of the jaw associated with pamidronate therapy". Am J ... is a nitrogen-containing bisphosphonate used to prevent osteoporosis. It is used to prevent vaginal loss, and treat prostatitis ...
"A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: ... Osteonecrosis of the jaw (deterioration of the temporomandibular joint or TMJ) may occur while on this drug, if dental work of ... It is the most widely prescribed bisphosphonate medicine in the United States . As with all potent bisphosphonates, the ... "Multiple systemic diseases complicated by bisphosphonate osteonecrosis: a case report". Ann Stomatol (Roma). 3 (2 Suppl): 32-6 ...
... women who have taken bisphosphonates for less than two years are four times more likely to suffer from osteonecrosis of the jaw ... Osteonecrosis: Osteonecrosis of the jaw is the slow destruction of bone in an extraction site. A case control study of 191 ... The presence of osteonecrosis of the jaw was reported by dentists' previous diagnosis of the participating case and control ... that women using bisphosphonates for more than two years are ten times more likely to experience osteonecrosis of the jaw, ...
... osteonecrosis of the jaw. As statins have a bone strengthening effect, combining a statin with an aromatase inhibitor could ... Bisphosphonates are sometimes prescribed to prevent the osteoporosis induced by aromatase inhibitors, but also have another ... without potential of causing osteonecrosis of the jaw. The more common adverse events associated with the use of aromatase ...
... namely bisphosphonate-related osteonecrosis of the jaw (BRONJ). History[edit]. The condition, or types of it, has had various ... Bisphosphonates[edit]. In 1998, a clinical trial demonstrated the effectiveness of intravenous pamidronate, a bisphosphonate ... Although oral bisphosphonates are more convenient and cheaper, they are not absorbed as well, and intravenous bisphosphonates ... Bisphosphonates are less effective for OI in adults.[58] Surgery[edit]. Metal rods can be surgically inserted in the long bones ...
Purcell, P. Boyd, I (2005). "Bisphosphonates and osteonecrosis of the jaw". Medical Journal of Australia. 182 (8): 417-418.. ... "6.6.2 Bisphosphonates". British National Formulary (54 ed.). British Medical Association and Royal Pharmaceutical Society of ...
In common with other bisphosphonate drugs, risedronate appears to be associated with the rare side effect osteonecrosis of the ... jaw, often preceded by dental procedures inducing trauma to the bone. Richard Eastell "P&G Press statement". Uk.pg.com. ... The manufacturers of Boniva, a rival bisphosphonate, were accused in the suit of causing a "serious public health risk" through ... Risedronic acid (INN) often used as its sodium salt risedronate sodium (USAN) is a bisphosphonate used to strengthen bone, ...
Osteonecrosis of the jaw Bisphosphonate-associated osteonecrosis of the jaw Industrial injury Radium jaw "Workshops of Horror ... Phossy jaw Durie BG, Katz M, Crowley J (July 2005). "Osteonecrosis of the jaw and bisphosphonates". N. Engl. J. Med. 353 (1): ... Bis-phossy jaws' - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw". Department of Oral and ... bisphosphonate-associated osteonecrosis of the jaw (BON), has been described as a side-effect of amino-bisphosphonates, a class ...
Similarly to bisphosphonates, denosumab appears to be implicated in increasing the risk of osteonecrosis of the jaw (ONJ) ... and osteonecrosis of the jaw and atypical femur fractures. Another trial showed significantly increased rates of eczema and ... following extraction of teeth or oral surgical procedures but, unlike bisphosphonate, the risk declines to zero approximately 6 ...
Latin American liquid candy product Bisphosphonate-associated osteonecrosis of the jaw, aka BON of the jaw Bankon language, ...
All-on-4 Bisphosphonate-associated osteonecrosis of the jaw Bruxism Edentulism Occlusal trauma Temporomandibular joint disorder ...
... bisphosphonate-related osteonecrosis of the jaws or oral pathology related to radiation therapy. Additionally, it is involved ...
... condition from the relatively recent and better known iatrogenic phenomenon of bisphosphonate-caused Osteonecrosis of the jaws ... Former and colloquial names include Osteonecrosis of the jaws (ONJ), cavitations, dry or wet socket, and NICO (neuralgia- ... inducing Cavitational osteonecrosis). The current, more correct, term, osteomyelitis of the jaws, differentiates the ... hematogenous OM in the bones of the jaws is rare. OM of the jaws is mainly caused by spread of adjacent odontogenic infection. ...
Woo S, Hellstein J, Kalmar J (2006). "Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws". Ann Intern ... Bisphosphonates, when administered intravenously for the treatment of cancer, have been associated with osteonecrosis of the ... Bisphosphonates are beneficial in reducing the risk of vertebral fracture in steroid induced osteoporosis. Bisphosphonates are ... Bisphosphonates are structurally similar to pyrophosphate (see figure above). A bisphosphonate group mimics pyrophosphate's ...
... bisphosphonate-associated osteonecrosis of the jaw) since 2003. The possible risk from lower oral doses of bisphosphonates, ... Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). ... "Statement by Merck regarding Fosamax and rare cases of osteonecrosis of the jaw". Merck. "Osteonecrosis of the Jaw". Novartis. ... estimated an incidence of osteonecrosis of the jaw of 1.15% for intravenous bisphosphonates and 0.04% for oral bisphosphonates ...
2008). "'Bis-phossy jaws' - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw". Journal of Cranio- ... There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. Avoiding the use of bisphosphonates is not ... Hyperbaric oxygen therapy Ultrasonic therapy Osteonecrosis of the jaw, see section on Bisphosphonates Phossy jaw C-terminal ... it is hypothesized that bisphosphonate-associated osteonecrosis of the jaw is related to a defect in jaw bone healing and ...
Long term inhalation of derivative fumes causes a condition called phossy jaw or osteonecrosis of the jaw, which is a painful, ... This condition may also be caused by high doses of lead, cadmium and bisphosphonate based cancer drugs. There are multiple ... leading to the putrid rotting of the bone of the lower jaw. For this reason, the Berne Convention (1906) was enacted to forbid ...
Osteonecrosis *Bisphosphonate-associated. *Neuralgia-inducing cavitational osteonecrosis. *Osteoradionecrosis. *Osteoporotic ... Temporomandibular joints, muscles of mastication and malocclusions - Jaw joints, chewing muscles and bite abnormalities ...
BPs are well tolerated, but preventive strategies must be instituted to avoid renal toxicity or osteonecrosis of the jaw. ... Bisphosphonates (BPs) should be considered in all patients with MM receiving first-line antimyeloma therapy, regardless of ... BPs are well tolerated, but preventive strategies must be instituted to avoid renal toxicity or osteonecrosis of the jaw. ... BPs are well tolerated, but preventive strategies must be instituted to avoid renal toxicity or osteonecrosis of the jaw. ...
  • Bisphosphonates (BPs) should be considered in all patients with MM receiving first-line antimyeloma therapy, regardless of presence of osteolytic bone lesions on conventional radiography. (elsevier.com)
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