Bisphosphonate associated osteonecrosis of the jaw. Medical search

Death of a bone or part of a bone, either atraumatic or posttraumatic.

Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.

Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.

Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.

Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE.

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.

A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.

A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.

The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)

Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Tumors or cancer located in bone tissue or specific BONES.

Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.

A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.

The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.

Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.

The surgical removal of a tooth. (Dorland, 28th ed)

Bone loss due to osteoclastic activity.

Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.

The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.

Congenital absence of or defects in structures of the jaw.

The longest and largest bone of the skeleton, it is situated between the hip and the knee.

Abnormally high level of calcium in the blood.

Fractures of the femur.

A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.

Breaks in bones.

The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.

Fractures due to the strain caused by repetitive exercise. They are thought to arise from a combination of MUSCLE FATIGUE and bone failure, and occur in situations where BONE REMODELING predominates over repair. The most common sites of stress fractures are the METATARSUS; FIBULA; TIBIA; and FEMORAL NECK.

Dissolution of bone that particularly involves the removal or loss of calcium.

Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.

Diseases of BONES.

The grafting of bone from a donor site to a recipient site.

A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.

Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

A PREDNISOLONE derivative with similar anti-inflammatory action.

The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.

The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.

A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

An enzyme involved in the MEVALONATE pathway, it catalyses the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)

Types of prosthetic joints in which both wear surfaces of the joint coupling are metallic.

The giving of drugs, chemicals, or other substances by mouth.

Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).

Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Removal of minerals from bones during bone examination.

Replacement of the hip joint.

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.

Elements of limited time intervals, contributing to particular results or situations.

Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)

Treatment for the prevention of periodontal diseases or other dental diseases by the cleaning of the teeth in the dental office using the procedures of DENTAL SCALING and DENTAL POLISHING. The treatment may include plaque detection, removal of supra- and subgingival plaque and calculus, application of caries-preventing agents, checking of restorations and prostheses and correcting overhanging margins and proximal contours of restorations, and checking for signs of food impaction.

The surgical cutting of a bone. (Dorland, 28th ed)

A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.

Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.

Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.

A family of flightless, running BIRDS, in the order Casuariiformes. The emu is the only surviving member of the family. They naturally inhabit forests, open plains, and grasslands in Australia.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.

The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.

The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.

Necrosis of bone following radiation injury.

Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.

The shaft of long bones.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.

Pain in the joint.

The total absence of teeth from either the mandible or the maxilla, but not both. Total absence of teeth from both is MOUTH, EDENTULOUS. Partial absence of teeth in either is JAW, EDENTULOUS, PARTIALLY.

The process of bone formation. Histogenesis of bone including ossification.

Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)

A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)

The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).

The application, via IMPLANTED ELECTRODES, of short bursts of electrical energy in the radiofrequency range, interspersed with pauses in delivery of the current long enough to dissipate the generated heat and avoid heat-induced tissue necrosis.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also nonepithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst. True jaw cysts are classified as odontogenic or nonodontogenic.

The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.

The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur.

A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.

Inorganic compounds that contain nitrogen as an integral part of the molecule.

Congenital dislocation of the hip generally includes subluxation of the femoral head, acetabular dysplasia, and complete dislocation of the femoral head from the true acetabulum. This condition occurs in approximately 1 in 1000 live births and is more common in females than in males.

Tumors or cancer of the human BREAST.

Injections made into a vein for therapeutic or experimental purposes.

The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

Surgical procedures used to treat disease, injuries, and defects of the oral and maxillofacial region.

The largest of three bones that make up each half of the pelvic girdle.

The relationship between the dose of an administered drug and the response of the organism to the drug.

The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Replacement for a hip joint.

Broken bones in the vertebral column.

Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.

Artificial substitutes for body parts and materials inserted into organisms during experimental studies.

A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

The magnetic stimulation of specific target tissues or areas of the body for therapeutic purposes via the application of magnetic fields generated by MAGNETS or ELECTROMAGNETS.

The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.

A masticatory muscle whose action is closing the jaws.

An anti-inflammatory 9-fluoro-glucocorticoid.

Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.

COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.

Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.

The properties, processes, and behavior of biological systems under the action of mechanical forces.

X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.

Absence of teeth from a portion of the mandible and/or maxilla.

A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.

A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.

Surgical reconstruction of a joint to relieve pain or restore motion.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience. (1/45)

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Taking the lead: sharing best practice in intravenous bisphosphonate use in urological cancers. (2/45)

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CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma. (3/45)

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Extraction socket healing in rats treated with bisphosphonate: animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients. (4/45)

AIM: The aim of this study is to replicate both clinical and histological presentation of bisphosphonate induced osteonecrosis of the jaws (BONJ) in an animal model of the disease state. Successful recapitulation of a BONJ-like indication in an animal model will be useful for studying pathogenesis, as well as prevention and treatment strategies for BONJ. MATERIALS AND METHODS: Eighty (80) rats were prospectively and randomly divided into two groups; control group(40) and study group(40). All animals in study group, injected with a dose of 1 mg/kg dexamethasone (DX) subcutaneously on day 7, 14, or 21; and 1, 2, or 3 doses of 7.5 microg/kg zoledronic acid (ZA) subcutaneously administered to coincide with the last day of DX. Half of the animals from each group underwent extraction of the left mandibular molars and the remaining animals underwent extraction of the left maxillary molars under pentobarbital-induced general anesthesia. All animals were euthanized twenty-eight (28) days following tooth extractions. RESULTS: The amount of new bone trabecules as significantly decreased in bisphosphonate-dexamethasone (BP-DX) treated sockets. Difference between both groups was found statistically significant (p=0,0001). There's no foreign body reaction in sockets of both groups and no significance difference observed for fibrosis (p=0,306). The necrosis scores were significantly higher in BP-DX treated sockets (p=0,015). The inflamation scores were significantly higher for study group (p=0,0001). CONCLUSION: This study provides preliminary observations for the development of an animal model of BONJ. But we think that there is need for other studies have only BP treated group and larger study population. (+info)

Bisphosphonate-related osteonecrosis of the jaws. (5/45)

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Antibiotic effects on bacterial profile in osteonecrosis of the jaw. (6/45)

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A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosis. (7/45)

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Use of cone-beam computerized tomography for evaluation of bisphosphonate-associated osteonecrosis of the jaws in an experimental rat model. (8/45)

BACKGROUND: Bisphosphonate-induced osteonecrosis of the jaw (BONJ) is a frequently reported complication. The aim of this study was to investigate the clinical and histopathological presentation of BONJ with the Hounsfield score and to evaluate the reliability of the score for determining necrosis in an animal model. MATERIAL/METHODS: Eighty rats were prospectively and randomly divided into two groups of 40 each: a control group and an experimental group. Half of the animals from each group underwent extraction of the left mandibular molars, and the other half underwent extraction of the left maxillary molars under pentobarbital-induced general anesthesia. All animals were euthanized 28 days after tooth extraction. Maxillae and mandibles were extracted, cone beam computed tomography (CBCT) was performed, and Hounsfield scores were evaluated. RESULTS: The Hounsfield scores of the experimental group were found to be compatible with chronic osteomyelitis and periosteal reactions. The Hounsfield scores of the control group were compatible with a healthy healing period. CONCLUSION: In light of these results, both cone beam computed tomography (CBCT) and the Hounsfield Units (HU) evaluations together are thought to be efficient in the diagnosis of BONJ. (+info)

2004). "Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases". J Oral Maxillofac Surg. 62 ... Ruggiero, SL (2008). "Bisphosphonate-related Osteonecrosis of the Jaws". Compend Contin Educ Dent. 29 (2): 97-105. PMID ... In order to evaluate the risk of osteonecrosis for a patient taking bisphosphonates, use of the CTX biomarker was introduced in ... 2007). "Oral Bisphosphonate-Induced Osteonecrosis: Risk Factors, Prediction of Risk Using Serum CTX Testing, Prevention, and ...

https://en.wikipedia.org/wiki/C-terminal_telopeptide

Durie BG, Katz M, Crowley J (2005). "Osteonecrosis of the jaw and bisphosphonates". N. Engl. J. Med. 353 (1): 99-102, ... and osteonecrosis of the jaw. Use during pregnancy may result in harm to the baby. It is in the bisphosphonate family of ... complication that has been recently observed in cancer patients being treated with bisphosphonates is osteonecrosis of the jaw ... As a nitrogenous bisphosphonate, Zoledronic acid is a potent inhibitor of bone resorption, allowing the bone-forming cells time ...

https://en.wikipedia.org/wiki/Zoledronic_acid

Dannemann C, Grätz KW, Riener MO, Zwahlen RA (April 2007). "Jaw osteonecrosis related to bisphosphonate therapy: a severe ... Bisphosphonates are associated with osteonecrosis of the mandible. Prolonged, repeated exposure to high pressures (as ... Osteonecrosis / Avascular Necrosis at the National Institute of Health Osteonecrosis / Avascular necrosis at Merck Manual for ... Bisphosphonates which reduce the rate of bone breakdown may prevent collapse (specifically of the hip) due to AVN. Other ...

https://en.wikipedia.org/wiki/Avascular_necrosis

Ruggiero, Salvatore L. (2007). "Guidelines for the diagnosis of bisphosphonate-related osteonecrosis of the jaw (BRONJ)". ... Osteonecrosis is a condition in which lack of blood supply causes the bone to die off. It mainly presents following ... This is because the tooth is not fused to the bones of the jaws, but is connected to the sockets by the periodontal ligament. ... A dental splint works by evening out pressure across a patients jaw. A splint can be used to protect teeth from further damage ...

https://en.wikipedia.org/wiki/Tooth_mobility

October 2007). "Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and ... Woo SB, Hellstein JW, Kalmar JR (May 2006). "Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws". ... A recognized risk of this drug relevant to dental treatments is bisphosphonate-associated osteonecrosis of the jaw (BRONJ). ... It is proposed this hearing loss is a secondary feature to attrition; this type of tooth wear can cause jaw overclosure with ...

https://en.wikipedia.org/wiki/Dentinogenesis_imperfecta

Microbial biofilms in osteomyelitis of the jaw and osteonecrosis of the jaw secondary to bisphosphonate therapy. J Am Dent ... "Microbial Biofilms in Osteomyelitis of the Jaw and Osteonecrosis of the Jaw Secondary to Bisphosphonate Therapy". "The in vivo ... Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: an institutional inquiry. J Am Dent Assoc 2009;140:61- ... Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy. J Oral Maxillofac Surg ...

https://en.wikipedia.org/wiki/Parish_Sedghizadeh

"Interventions for treating osteonecrosis of the jaw bones associated with bisphosphonates". Reviews. doi:10.1002/14651858. ... Osteonecrosis of the jaws refers to the death of bone marrow in the maxilla or the mandible due to inadequate blood supply. It ... The term NICO is used to describe pain caused by ischemic osteonecrosis of the jaws, where degenerative extracellular cystic ... Neuralgia-inducing cavitational osteonecrosis (NICO) is a controversial term, and it is questioned to exist by many. ...

https://en.wikipedia.org/wiki/Atypical_facial_pain

"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-- ... procedures on the lower jaw, people with other medical issues, those on steroids, those on more potent bisphosphonates and ... because they have been associated with a disorder called Medication-associated osteonecrosis of the jaw (MRONJ). The drugs ... the local health condition of the mucous membranes and the jaws and the shape, size, and position of the bones of the jaws, ...

https://en.wikipedia.org/wiki/Dental_implant

... can also be associated with the radiographic changes seen in those with bisphosphonate-related osteonecrosis of the jaw.[ ...

https://en.wikipedia.org/wiki/Osteolysis

Osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including ... Zarychanski R, Elphee E, Walton P, Johnston J (2006). "Osteonecrosis of the jaw associated with pamidronate therapy". Am J ... Pamidronic acid or pamidronate disodium or APD (marketed as Aredia among others), is a nitrogen-containing bisphosphonate used ... v t e (ECHA InfoCard ID from Wikidata, Bisphosphonates, Farnesyl pyrophosphate synthase inhibitors, Nephrotoxins, All stub ...

https://en.wikipedia.org/wiki/Pamidronic_acid

... thalassaemia major patients may also be on bisphosphonates and are therefore at risk of developing osteonecrosis of the jaw. ... It is managed with the used of bisphosphonates. Prior to placement on bisphosphonates, a dental check must be done to extract ... A heart attack can cause pain the chest; sometimes this pain can radiate up to the jaw. (Malik et al., 2013) Calcium channel ... Sickle patients can experience sickle crisis, these are painful events in which if in the jaw can mimic dental pain and facial ...

https://en.wikipedia.org/wiki/Oral_manifestations_of_systemic_disease

There are concerns of atypical femoral fractures and osteonecrosis of the jaw with long-term use, but these risks are low. With ... Different bisphosphonates have not been directly compared, therefore it is unknown if one is better than another. Fracture risk ... Bisphosphonate medications are useful to decrease future broken bones in those with previous broken bones due to osteoporosis. ... Among the five bisphosphonates, no significant differences were found for a secondary fracture for all fracture endpoints ...

https://en.wikipedia.org/wiki/Osteoporosis

"Osteonecrosis of the jaw (ONJ) and drug treatments for osteoporosis" (PDF). nos.org.uk. The National Osteoporosis Society. ... A study conducted by the American Society of Bone and Mineral Research concluded that long-term use of bisphosphonates, ... The drug also has been associated with osteonecrosis of the jaw, relatively rare but serious condition. Ibandronic acid is ... Sittig HB (2012). "Pathogenesis and bisphosphonate treatment of skeletal events and bone pain in metastatic cancer: focus on ...

https://en.wikipedia.org/wiki/Ibandronic_acid

... women who have taken bisphosphonates for less than two years are four times more likely to suffer from osteonecrosis of the jaw ... Osteonecrosis: Osteonecrosis of the jaw is the slow destruction of bone in an extraction site. A case control study of 191 ... The presence of osteonecrosis of the jaw was reported by dentists' previous diagnosis of the participating case and control ... that women using bisphosphonates for more than two years are ten times more likely to experience osteonecrosis of the jaw, ...

https://en.wikipedia.org/wiki/Dental_extraction

... osteonecrosis of the jaw. As statins have a bone strengthening effect, combining a statin with an aromatase inhibitor could ... Bisphosphonates are sometimes prescribed to prevent the osteoporosis induced by aromatase inhibitors, but also have another ... without potential of causing osteonecrosis of the jaw. The more common adverse events associated with the use of aromatase ...

https://en.wikipedia.org/wiki/Aromatase_inhibitor

"A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: ... Osteonecrosis of the jaw may occur while on this drug, if dental work of any kind is carried out. The risk is considerably ... "Multiple systemic diseases complicated by bisphosphonate osteonecrosis: a case report". Annali di Stomatologia. 3 (2 Suppl): 32 ... Like all bisphosphonates, it is chemically related to inorganic pyrophosphate, the endogenous regulator of bone turnover. But ...

https://en.wikipedia.org/wiki/Alendronic_acid

In common with other bisphosphonate drugs, risedronate appears to be associated with the rare side effect osteonecrosis of the ... jaw, often preceded by dental procedures inducing trauma to the bone. "Actonel- risedronate sodium tablet, film coated". ... Risedronic acid, often used as its sodium salt risedronate sodium, is a bisphosphonate. It slows down the cells which break ... The manufacturers of Boniva, a rival bisphosphonate, were accused in the suit of causing a "serious public health risk" through ...

https://en.wikipedia.org/wiki/Risedronic_acid

... medication-related osteonecrosis of the jaw (MRONJ). However, no report of bisphosphonate-related MRONJ in either a child or ... Although oral bisphosphonates are more convenient and cheaper, they are not absorbed as well, and intravenous bisphosphonates ... Bisphosphonates are not as effective at increasing the bone mineral density of adults. OI is a genetic disorder and is not ... Bisphosphonates are especially effective in children, however it is unclear if they either increase quality of life or decrease ...

https://en.wikipedia.org/wiki/Osteogenesis_imperfecta

Similarly to bisphosphonates, denosumab appears to be implicated in increasing the risk of osteonecrosis of the jaw (ONJ) ... osteonecrosis of the jaw, and atypical femur fractures. Another trial showed significantly increased rates of eczema and ... following extraction of teeth or oral surgical procedures but, unlike bisphosphonate, the risk declines to zero approximately 6 ...

https://en.wikipedia.org/wiki/Denosumab

Latin American liquid candy product Bisphosphonate-associated osteonecrosis of the jaw, aka BON of the jaw Bankon language, ...

https://en.wikipedia.org/wiki/Bon_(disambiguation)

All-on-4 Bisphosphonate-associated osteonecrosis of the jaw Bruxism Edentulism Occlusal trauma Temporomandibular joint disorder ...

https://en.wikipedia.org/wiki/Prosthodontics

... bisphosphonate-related osteonecrosis of the jaws or oral pathology related to radiation therapy. Additionally, it is involved ...

https://en.wikipedia.org/wiki/Oral_medicine

Wales Bisphosphonate-associated osteonecrosis of the jaw or BRONJ, a complication of certain dental procedures for patients on ... bisphosphonate therapy Bronn (disambiguation) Brons This disambiguation page lists articles associated with the title Bron. If ...

https://en.wikipedia.org/wiki/Bron_(disambiguation)

... health should be evaluated to assess the risk factors to prevent the development of medication-related osteonecrosis of the jaw ... Bisphosphonates and radiation therapy are sometimes used to reduce pain from bone lesions. Globally, multiple myeloma affected ... In addition to direct treatment of the plasma cell proliferation, bisphosphonates (e.g., pamidronate or zoledronic acid) are ... MRONJ). If there are any symptoms or radiographic appearance of MRONJ like jaw pain, loose tooth, mucosal swelling, early ...

https://en.wikipedia.org/wiki/Multiple_myeloma

... bisphosphonate-associated osteonecrosis of the jaw (BON), has been described as a side-effect of amino-bisphosphonates, a class ... "Bis-phossy jaws" - High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw". Journal of Cranio- ... "Bisphosphonates and jaw osteonecrosis". Medscape. Pollock, RA; Brown TW, Jr; Rubin, DM (September 2015). ""Phossy Jaw" and "Bis ... Durie BG; Katz M; Crowley J (July 2005). "Osteonecrosis of the jaw and bisphosphonates". N. Engl. J. Med. 353 (1): 99-102, ...

https://en.wikipedia.org/wiki/Phossy_jaw

... including kidney failure for treatment with zoledronic acid and osteonecrosis of the jaw for denosumab. As an alternative to ... Bisphosphonates such as zoledronic acid have been shown to delay skeletal complications such as fractures or the need for ... For men with prostate cancer and bone metastases zoledronic acid (a bisphosphonate) and denosumab (a RANK-ligand-inhibitor) ... Cochrane Urology Group) (December 2020). "Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone ...

https://en.wikipedia.org/wiki/Management_of_prostate_cancer

Woo S, Hellstein J, Kalmar J (2006). "Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws" (PDF). Ann ... Bisphosphonates, when administered intravenously for the treatment of cancer, have been associated with osteonecrosis of the ... Once bisphosphonates are in bone, they have a very long elimination half-life that can exceed ten years. Bisphosphonates are ... Bisphosphonates are beneficial in reducing the risk of vertebral fracture in steroid induced osteoporosis. Bisphosphonates are ...

https://en.wikipedia.org/wiki/Bisphosphonate

... condition from the relatively recent and better known iatrogenic phenomenon of bisphosphonate-caused osteonecrosis of the jaws ... Former and colloquial names include Osteonecrosis of the jaws (ONJ), cavitations, dry or wet socket, and NICO (Neuralgia- ... Inducing Cavitational osteonecrosis). The current, more correct, term, osteomyelitis of the jaws, differentiates the ... hematogenous OM in the bones of the jaws is rare. OM of the jaws is mainly caused by spread of adjacent odontogenic infection. ...

https://en.wikipedia.org/wiki/Osteomyelitis_of_the_jaws

... bisphosphonate-associated osteonecrosis of the jaw) since 2003. The possible risk from lower oral doses of bisphosphonates, ... Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). ... "Statement by Merck regarding Fosamax and rare cases of osteonecrosis of the jaw". Merck. "Osteonecrosis of the Jaw". Novartis. ... estimated an incidence of osteonecrosis of the jaw of 1.15% for intravenous bisphosphonates and 0.04% for oral bisphosphonates ...

https://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw

There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. Avoiding the use of bisphosphonates is not ... This condition was previously known as bisphosphonate-related osteonecrosis of the jaw (BON or BRONJ) because osteonecrosis of ... American Dental Association Osteonecrosis of the Jaw Archived 2009-08-03 at the Wayback Machine "Osteonecrosis of the jaw (ONJ ... a term for osteonecrosis caused by radiotherapy Phossy jaw Nase JB, Suzuki JB (August 2006). "Osteonecrosis of the jaw and oral ...

https://en.wikipedia.org/wiki/Medication-related_osteonecrosis_of_the_jaw

Osteonecrosis, Jaw disorders). ... Clodronate is a non-nitrogenous bisphosphonate used in the ... from jaw to skin) Infection in gums/teeth Extra-oral draining sinuses Lymphadenopathy Malocclusion Jaw fracture Sequestrum ( ... A practical recommendation is provided in some case where it is necessary to extract teeth from the jaw after radiotherapy. An ... Early indicators may be numbness or paresthesias within the mouth or jaw. Other signs and symptoms include: Pain Swelling Non- ...

https://en.wikipedia.org/wiki/Osteoradionecrosis

... in a class action lawsuit alleging that the company's osteoporosis drug had caused them to develop osteonecrosis of the jaw. ... Fosamax (alendronate) is a bisphosphonate used for the treatment of post-menopausal osteoporosis and for the prevention of ... Eriksen EF, Díez-Pérez A, Boonen S (January 2014). "Update on long-term treatment with bisphosphonates for postmenopausal ... Menopause Society and the UK National Osteoporosis Guideline Group recommend alendronate and certain other bisphosphonates as ...

https://en.wikipedia.org/wiki/Merck_&_Co.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) manifests as exposed, nonvital bone involving the maxillofacial ... is a condition found in patients who have received intravenous and oral forms of bisphosphonate therapy for various bone- ... encoded search term (Bisphosphonate-Related Osteonecrosis of the Jaw) and Bisphosphonate-Related Osteonecrosis of the Jaw What ... Management of bisphosphonate-related osteonecrosis of the jaw. Nonsurgical management of bisphosphonate-related osteonecrosis ...

http://emedicine.medscape.com/article/1447355-overview

Evaluating the effects of small extracellular vesicles derived from adipose tissue administration on bisphosphonate-related ... Small Extracellular Vesicles Derived from Adipose Tissue Prevent Bisphosphonate-Related Osteonecrosis of the Jaw by Promoting ...

https://www.dovepress.com/article_metric.php?article_id=64568

Keywords: Bisphosphonates, osteonecrosis, jaw Abstract. Bisphosphonates have been widely prescribed for treatment of diseases ... avascular osteonecrosis of the jaws. The authors present a literature review on bisphosphonates, focusing on their ... If the therapy with bisphosphonate is indicated, rigorous oral health adequacy must be performed and periodic evaluation of ... pharmacological features and their reported association with jaw osteonecrosis. The morbidity and lack of treatment response of ...

https://revistaseletronicas.pucrs.br/index.php/fo/article/view/4960

Dive into the research topics of Systematic review on the incidence of bisphosphonate related osteonecrosis of the jaw in ... keywords = "osteonecrosis, jaw, osteogenesis imperfecta, children, bisphosphonates",. author = "Hennedige, {Anusha Adeline} and ... Systematic review on the incidence of bisphosphonate related osteonecrosis of the jaw in children diagnosed with osteogenesis ... Systematic review on the incidence of bisphosphonate related osteonecrosis of the jaw in children diagnosed with osteogenesis ...

https://abdn.pure.elsevier.com/en/publications/systematic-review-on-the-incidence-of-bisphosphonate-related-oste

Bisphosphonate-Associated Osteonecrosis of the Jaw Posing as a Diagnostic Tight Spot. IJSS Case Reports & Reviews. 2015 July; 2 ... Bisphosphonate-Associated Osteonecrosis of the Jaw Posing as a Diagnostic Tight Spot. ... A 60-year-old male patient was referred for dental consultation by a physician following bone necrosis of jaw bones. He had ... Intraoral examination revealed denuded necrotic bone bilaterally on the posterior aspect of both the jaws (Figures 1-3). There ...

https://imsear.searo.who.int/handle/123456789/169118

... but prolonged use could potentially lead to osteonecrosis of the jaw. Which patients are most at risk? ... Do not discontinue bisphosphonatesb Do not discontinue denosumab-perform procedure preferably 5-6 mo following the last ... Osteonecrosis of the jaw (ONJ) is a rare but severe condition manifested as necrotic bone lesion or lesions of the jaws. ONJ ... Abbreviations: ONJ, osteonecrosis of the jaw; SRE, skeletal-related event.. aA few, not well-documented cases of ONJ reported ...

https://www.medscape.com/viewarticle/980468

Jaw Aseptic Necrosis, Mandibular Osteonecrosis, Mandible Aseptic Necrosis, Bisphosphonate-Associated Osteonecrosis of the Jaw, ... Bisphosphonate-Related Osteonecrosis of the Jaw, Bisphosphonate Related Osteonecrosis of the Jaw, Osteonecrosis of the Jaws, ... Jaw Osteonecrosis. Jaw Osteonecrosis Aka: Jaw Osteonecrosis, Jaw Aseptic Necrosis, Mandibular Osteonecrosis, Mandible Aseptic ... Osteonecrosis of jaw due to bisphosphonate (disorder), Bisphosphonate related osteonecrosis of jaw, Osteonecrosis of jaw due to ...

https://fpnotebook.com/Dental/Jaw/JwOstncrs.htm

https://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw

... sometimes termed osteochemonecrosis or osteonecrosis) in the jaws, defined as bisphosphonate-induced osteonecrosis of the jaw ( ... Jaw osteonecrosis and bisphosphonates. In 1993 Fleisch11 first cited bisphosphonates as an alternative to hormone replacement ... Resolution of oral bisphosphonate and steroid-related osteonecrosis of the jaw-a serial case analysis ... Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction ...

https://meridian.allenpress.com/joi/article/38/1/85/2427/Immediate-Loading-in-Mandible-Full-Arch-Pilot

... bisphosphonate (BP). This retrospective study enrolled subjects who had been diagnosed with medication-related osteonecrosis of ... the jaw (MRONJ) during the period from July 2010 to June 2014. Information regarding the following demographic and clinical ... study was aimed to evaluate the clinical characteristics and treatment outcomes in patients with osteonecrosis of the jaw who ... From: Characteristics of patients with osteonecrosis of the jaw with oral versus intravenous bisphosphonate treatment ...

https://jkamprs.springeropen.com/articles/10.1186/s40902-021-00310-w/tables/1

The types of jaw injuries and disorders that can cause problems are dislocations, fractures, misaligned teeth and more. Learn ... Bisphosphonate Therapy (and Osteonecrosis of the Jaw) (American Association of Oral and Maxillofacial Surgeons) ... Osteonecrosis of the Jaw (ONJ) (American College of Rheumatology) Also in Spanish ... ClinicalTrials.gov: Jaw Diseases (National Institutes of Health) * ClinicalTrials.gov: Jaw Fractures (National Institutes of ...

https://medlineplus.gov/jawinjuriesanddisorders.html

Jaw Osteonecrosis as Potential Adverse Effect to Oral Bisphosphonate Therapy. October 02, 2014 ...

https://www.hcplive.com/journals/internal-medicine-world-report/september-2014

Hereby, we reported a patient who was operated to treat the mandibular bisphosphonate-related osteonecrosis of the jaw (BRONJ) ... Samieirad S, Tohidi E. Accessory Mental Foramen in a Patient with Mandibular Bisphosphonate-Related Osteonecrosis of the Jaw ( ... Accessory Mental Foramen in a Patient with Mandibular Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) Lesion: A Case ... Accessory Mental Foramen in a Patient with Mandibular Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) Lesion: A Case ...

http://wjps.ir/browse.php?a_id=530&sid=1&slc_lang=fa

Bisphosphonates have been linked to osteonecrosis and osteopetrosis of the jaws. Nov 01, 2005. ... Diseases : Osteonecrosis, Osteopetrosis. Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Pamidronate, ... Bisphosphonate use is associated with a significant increase in the risk of serious atrial fibrillation in postmenopausal women ... Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Zoledronic Acid. Adverse Pharmacological Actions : ...

https://greenmedinfo.com/toxic-ingredient/alendronate-trade-name-fosamax

Keywords: Bisphosphonates, bisphosphonate-related osteonecrosis of the jaw, endodontic treatment, review, root canal therapy ... "Bisphosphonate AND root canal therapy" and "Bisphosphonate associated osteonecrosis of the jaw AND endodontics.". Results: The ... "Bisphosphonate AND root canal therapy" and "Bisphosphonate associated osteonecrosis of the jaw AND endodontics.". Results: The ... "Bisphosphonate AND root canal therapy" and "Bisphosphonate associated osteonecrosis of the jaw AND endodontics." Initially, 70 ...

https://saudiendodj.com/article.asp?issn=1658-5984

keywords = "bisphosphonate-related osteonecrosis of the jaw, osteonecrosis, periodontal diseases, tooth extraction", ... and medication-related osteonecrosis of the jaw in women receiving bisphosphonates: A national cohort-based study. Journal of ... and medication-related osteonecrosis of the jaw in women receiving bisphosphonates: A national cohort-based study, Journal of ... and medication-related osteonecrosis of the jaw in women receiving bisphosphonates: A national cohort-based study. Together ...

https://pure.ewha.ac.kr/en/publications/association-between-periodontal-disease-tooth-extraction-and-medi

... our results indicate that endogenous SMOC2 blocks injury-induced jaw bone osteonecrosis and offsets age-induced periodontal ... Chronic inflammation produces increased bone loss in bisphosphonate-induced jaw osteonecrosis models35. Smoc2 deficiency ... IL-17-mediated M1/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws. ... This could be applied clinically to alleviate jaw osteonecrosis-like symptoms18, a frequent decisive consequence of tooth ...

https://www.nature.com/articles/s41598-020-71749-6?error=cookies_not_supported&code=55be3a3e-d4cc-4483-bef6-a9d2ebbf48af

Risk of osteonecrosis of the jaw may increase with duration of exposure to bisphosphonates ... Cases of osteonecrosis (primarily involving the jaw but also of other anatomical sites including hip, femur and external ... Increased risk of osteonecrosis of jaw (advise patients against dental work); reported predominantly in cancer patients treated ... Musculoskeletal: Muscle cramps, osteonecrosis of jaw, pain, atypical subtrochanteric and diaphyseal femoral fractures ...

http://reference.medscape.com/drug/342858

Keywords: bisphosphonates, osteonecrosis, jaw, fibroblast, gene expression Introduction. Bisphosphonates (BPs) are synthetic ... Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle?. J Oral Maxillofac Surg. ... Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer ... The aim of this study was to elucidate the role of fibroblasts in bisphosphonate-related osteonecrosis of the jaw (BRONJ), ...

https://medsci.org/v16p1534.htm

The aim of the present study was to elucidate the role of osteoblasts in bisphosphonates-related osteonecrosis of the jaw ( ... Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw. Int J Med Sci 2018; 15(4):359-367. doi:10.7150/ijms. ... Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw. Int J Med Sci 2018; 15(4):359-367. doi:10.7150/ijms. ... Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw. Int. J. Med. Sci. 2018, 15 (4), 359-367. DOI: 10.7150 ...

https://www.medsci.org/v15p0359

Patients who develop osteonecrosis of the jaw while on bisphosphonate therapy should receive care by an oral surgeon. In these ... Jaw Osteonecrosis. Osteonecrosis of the jaw and other oro-facial sites, including the external auditory canal, have been ... Jaw Osteonecrosis. Osteonecrosis of the jaw (ONJ), which can occur spontaneously, is generally associated with tooth extraction ... 4. Severe jaw bone problems (osteonecrosis).. Severe jaw bone problems may happen when you take Ibandronate Sodium Tablets. ...

https://www.drugs.com/pro/ibandronate-sodium-tablets.html

Should I Take Bisphosphonate Medicines?You may want to have a say in this decision, or you may simply want to follow your ... Problems with the jaw bone. This is called osteonecrosis. Research has shown that bisphosphonates seem to increase the chance ... Problems with the jaw bone. This is called osteonecrosis. Research has shown that bisphosphonates seem to increase the chance ... Take a bisphosphonateTake bisphosphonates. *You take bisphosphonate pills on a schedule such as once a week. Or you may get a ...

https://www.mottchildren.org/health-library/te7592

Journal Article] Novel insight into the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ)2019. *. Author(s) ... Journal Article] Treatment with teriparatide for advanced bisphosphonate-related osteonecrosis of the jaw around dental ...

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11737/

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) manifests itself as devitalized exposed bone in the maxillofacial ... A new complication from treatment with bisphosphonates has become an important disease condition for the dental professional to ...

https://www.experts.com/articles/oral-cancer-dental-patient-by-lee-whitesides

Rasmusson L, Abtahi J. Bisphosphonate associated osteonecrosis of the jaw: an update on pathophysiology, risk factors, and ... For example, patients taking bisphosphonates should be aware of the potential for osteonecrosis of the jaw. ... Bisphosphonates for Pagets disease of bone in adults. Cochrane Database Syst Rev. 2017 Dec 1. 12:CD004956. [QxMD MEDLINE Link] ... Treatment efficacy of bisphosphonates in Paget disease may be due to suppression of RANKL-induced bone resorption, with ...

https://emedicine.medscape.com/article/334607-overview

Piqray should not be initiated in patients with ongoing osteonecrosis of the jaw. ... Caution should be exercised when Piqray and bisphosphonates or denosumab are used together or sequentially. ...

https://www.novartis.com/news/media-releases/novartis-receives-piqray-approval-europe-first-and-only-targeted-medicine-hrher2-advanced-breast-cancer-pik3ca-mutation

Bisphosphonates are a group of medicines that treat bone problems, such as thin or fragile bones. See how to take it, side ... called osteonecrosis of the jaw. Osteonecrosis of the jaw is typically associated with an invasive procedure to the jaw (tooth ... There is a rare risk of developing jaw or tooth pain, called osteonecrosis of the jaw. It is typically associated with trauma ... Bisphosphonate Therapy Bisphosphonates are a group of medicines used to treat bone problems, called osteopenia or osteoporosis ...

https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Bisphosphonate-Therapy

Patients who develop osteonecrosis of the jaw while on bisphosphonate therapy should receive care by an oral surgeon. In these ... 5.4 Osteonecrosis of the Jaw. Osteonecrosis of the jaw (ONJ), which can occur spontaneously, is generally associated with tooth ... Severe jaw bone problems (osteonecrosis). Severe jaw bone problems may happen when you take BINOSTO. Your doctor should examine ... 5.4 Osteonecrosis of the Jaw 5.5 Atypical Subtrochanteric and Diaphyseal Femoral Fractures 5.6 Renal Impairment 5.7 Patients ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b278a11a-b8d7-49f3-9b38-29b67c4c417e

Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and ...

https://www.semanticscholar.org/topic/Periodontitis/89392

Evidence is insufficient to confirm a causal link between low-dose bisphosphonate use in osteoporosis with osteonecrosis of the jaw. (medscape.com)
The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat osteoporosis, remains uncertain. (wikipedia.org)
Osteoporosis: Should I Take Bisphosphonate Medicines? (mottchildren.org)
Bisphosphonates are the most common medicines used to prevent bone loss in people who have osteoporosis. (mottchildren.org)
Most cases were reported in cancer patients receiving intravenous bisphosphonates, but some have been in patients treated orally for osteoporosis. (news-medical.net)
Bisphosphonates are a group of medicines used to treat bone problems, called osteopenia or osteoporosis, which are conditions associated with thin or fragile bones that are at increased risk for fracture. (rheumatology.org)
The osteoporosis drugs Fosamax (alendronate), Actonel (risedronate), Zometa (zoledronic acid) and Boniva (ibandronate) are bisphosphonates - medicines that stop bone absorption. (sunjournal.com)
Osteonecrosis most often happens when these drugs are used in doses much higher than the ones used for osteoporosis, like the doses used for cancer that has spread to bone. (sunjournal.com)
Bisphosphonates are drugs widely used to treat bone disorders such as osteoporosis and bone metastases. (academicjournals.org)
Fosamax belongs to a class of drugs called bisphosphonates --which also includes drugs Actonel, Boniva and Reclast among others--that are prescribed to help prevent the loss of bone mass and are used to treat osteoporosis and similar diseases. (lawyersandsettlements.com)
Are Bisphosphonates Really Necessary for Osteoporosis Prevention? (holisticprimarycare.net)
Recent reports of jaw osteonecrosis have marred the reputation of these anti-osteoporosis drugs. (holisticprimarycare.net)
The study is among the first to acknowledge that even short-term use of common oral osteoporosis drugs may leave the jaw vulnerable to devastating necrosis, according to the report appearing in the January 1 Journal of the American Dental Association (JADA) . (news-medical.net)
The Fosamax trial will involve a complaint brought by Linda Secrest, of Florida, who alleges that Merck failed to adequately warn that side effects of Fosamax , the popular osteoporosis drug, can lead to severe jaw bone decay. (aboutlawsuits.com)
Fosamax is an osteoporosis drug that belongs to a family of similar medications known as bisphosphonates. (aboutlawsuits.com)
The cost of osteoporosis in the U.S. is estimated at $22 billion per year.1 Bisphosphonates (such as Fosamax, Boniva, Actonel, and Reclast) are commonly prescribed by physicians to treat osteoporosis or to prevent osteoporosis in individuals with osteopenia. (nutrientrich.com)
Several ONJ cases have been reported in patients taking oral bisphosphonates for osteoporosis or Paget's disease. (unimi.it)
The patients must be informed on the benefit/risk of bisphosphonate therapy and, when necessary and possible, alternative therapy for postmenopausal osteoporosis should be considered. (unimi.it)
A strong third-generation bisphosphonate, zoledronate, is currently approved to treat postmenopausal-induced osteoporosis. (ijbcp.com)
Bisphosphonates: preclinical aspects and use in osteoporosis. (ijbcp.com)
Fleisch H. New bisphosphonates in osteoporosis. (ijbcp.com)
Osteoporosis is routinely treated with bisphosphonates to prevent fractures. (skepdoc.info)
Bisphosphonate drugs have been shown to increase bone density and prevent fractures in postmenopausal women with osteoporosis (remember Sally Field in those ads for Boniva? (skepdoc.info)
Boniva is drug known as bisphosphonate which is used to treat and prevent certain types of bone loss like osteoporosis and Paget's Disease . (autoaccident.com)
She said that she would not recommend taking any bisphosphonates unless my bone density was -2.5 (osteoporosis) or worse. (twgbreastcancer.com)
Wikipedia also said that some women who took bisphosphonates for osteoporosis had unusual fractures in the shafts of their femurs. (twgbreastcancer.com)
Osteoporosis is typically treated with drugs known as bisphosphonates . (aernidental.com)
If that's not all, osteoporosis also leads to high calcium levels in the blood which bisphosphonates help circumvent. (aernidental.com)
Bisphosphonates, as a class, reduce bone loss associated with diseases such as osteoporosis, Paget's disease, multiple myeloma and metastatic bone disease. (redsdentists.org)
After the discovery of biological effects of bisphosphonates more than 30 years ago, they have now become indispensable in medicine for the treatment of skeletal complications of malignancy, Paget's disease, osteoporosis, multiple myeloma, hypercalcemia and fibrous dysplasia. (odontiatriko.gr)
It's not only rare, but also most often seen in cancer patients on high-dose IV bisphosphonates, said Dr. Robert Recker, who directs the Osteoporosis Research Center at Creighton University in Omaha, Neb. (blogspot.com)
Bisphosphonates have inexpensive generic versions, and they're the usual first-choice osteoporosis treatment. (blogspot.com)
Most people who take oral bisphosphonates for osteoporosis won't have to postpone or avoid dental procedures, because they have little risk of developing ONJ. (drchadbailey.com)
Osteoporosis & Dental Implants If you are taking a bisphosphonate drug for treatment of osteoporosis, any kind of surgery involving the jawbone has a small risk that bone healing may be compromised. (drchadbailey.com)
If you are taking a bisphosphonate drug for treatment of osteoporosis, any kind of surgery involving the jawbone has a small risk that bone healing may be compromised. (crystaldentalfresno.com)
A few weeks ago I wrote about osteoporosis , and one of the mainstays of treatment is a class of drugs called bisphosphonates. (straightanursingstudent.com)
The key use of bisphosphonates is in the treatment of bone disorders including osteoporosis, osteopenia, Paget's disease, hypercalcemia secondary to malignancy, and the treatment of some cancers. (straightanursingstudent.com)
Pamidronate (Aredia) - IV medication that may be used to treat osteoporosis in individuals who cannot tolerate oral bisphosphonates. (straightanursingstudent.com)
Our team and current working network of collaborators represent a world leading expertise in the use and development of drugs from bisphosphonate chemistry that has formerly produced several billion dollar therapies for the treatment of osteoporosis and the skeletal complications of cancer bone metastases. (biovinc.com)
In particular, BV President/CSO and co-founder Dr. Frank (Hal) Ebetino was a member of the team that discovered and developed the bisphosphonate drug Actonel® for Osteoporosis at Procter & Gamble Pharmaceuticals, and BV founder and long-time academic bisphosphonate researcher, Professor Charles McKenna has developed multiple exciting antiviral and anti-cancer drug candidates. (biovinc.com)
The optimal total duration of antiresorptive treatment for osteoporosis (including both denosumab and bisphosphonates) has not been established. (amgen.sa)
Introduction: Osteonecrosis of the jaws is a rare, severe adverse reaction associated with the administration of drugs used to treat osteoporosis and cancer, such as bisphosphonates and denosumab. (revistadeosteoporosisymetabolismomineral.com)
Conclusion: Our results suggest that the respondents had little knowledge as to the risk of developing maxillary osteonecrosis with the use of medications for the management of osteoporosis. (revistadeosteoporosisymetabolismomineral.com)
The risk of ONJ with bisphosphonates and denosumab in osteoporosis therapy is very low, close to 0.01%, as it is a low-dose and short-exposure therapy, unlike when they are used in cancer patients, with a risk of around 1.3% [3,4]. (revistadeosteoporosisymetabolismomineral.com)
Although the risk of ONJ is very low with the use of bisphosphonates and denosumab in osteoporosis, dental professionals still perceive a high risk of presenting this complication. (revistadeosteoporosisymetabolismomineral.com)
This study aims to ascertain the degree of knowledge and the clinical decisions that Colombian dentists make regarding ONJ risk associated with the use of bisphosphonates and denosumab in osteoporosis. (revistadeosteoporosisymetabolismomineral.com)
Patients who suffer serious conditions such as broken bones or osteonecrosis may find themselves unable to work or, predictably, facing even higher medical expenses than they would have expected, even if they were already diagnosed with a serious conditions such as osteoporosis. (tuckerinjurylawyer.com)

Osteonecrosis of the jaw associated with bisphosphonate therapy, which is required by some cancer treatment regimens, has been identified and defined as a pathological entity (bisphosphonate-associated osteonecrosis of the jaw) since 2003. (wikipedia.org)
This pathology is an exposure of bone tissue located in the arches (maxillary, mandibular, or both) that persists for more than 6-8 weeks, associated with bisphosphonate therapy and in the absence of previous radiotherapy. (saudiendodj.com)
Abnormal fractures of the femur (thigh bone, atypical femoral fracture) have been associated with bisphosphonate therapy, especially if the medication is taken for many years. (rheumatology.org)
Osteonecrosis of the jaw is basically severe bone disease which is associated with bisphosphonate therapy (Zometa and now Xgeva). (malecare.org)

In patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ), panoramic and plain radiography of the mandible reveal areas of sclerosis, destruction, sequestration, or pathologic fractures. (medscape.com)
Take a bisphosphonate to lower the risk of bone fractures. (mottchildren.org)
Atypical subtrochanteric and diaphyseal femoral fractures have been reported in patients receiving bisphosphonate therapy. (nih.gov)
The "impetus for the study" was the assumption that bisphosphonates have a direct cancer-fighting effect -- something that has been controversial, commented Harold Burstein, MD, PhD , of Dana-Farber Cancer Institute in Boston, so it makes sense that it might prevent fractures in cancer patients. (medpagetoday.com)
Fosamax side effects include Fosamax osteonecrosis , also known as Fosamax dead jaw, and recently Fosamax femur fractures . (lawyersandsettlements.com)
Since 2006, hundreds of Fosamax ONJ lawsuits against Merck, the manufacturer of Fosamax (the brand name for Alendronate), claim that rather than increasing bone density and strengthening bones, in some cases Fosamax has actually caused a deterioration of the jaw bone or contributed to femur fractures. (lawyersandsettlements.com)
Unfortunately, bisphosphonates may actually increase one's risk of mid-femur fractures (the femur is your upper leg bone). (nutrientrich.com)
Long term (4-8 years) users of bisphosphonates have significantly higher risks of atypical hip and leg fractures.3 Most of these fractures are not the result of falls. (nutrientrich.com)
Long-term bisphosphonates increased risk for 2 rare harms: atypical femoral fractures (low SOE) and osteonecrosis of the jaw (mostly low SOE). (umn.edu)
Long-term bisphosphonate treatment may increase risk for rare adverse events, and continuing treatment beyond 3 to 5 years may reduce risk for vertebral fractures. (umn.edu)
The concern is that after years of use, the drugs may in rare cases actually lead to weaker bones in certain women, contributing to "rare but serious adverse events," including unusual femur fractures, esophageal cancer and osteonecrosis of the jaw, a painful and disfiguring crumbling of the jaw bone. (drug-injury.com)
Bisphosphonates (pamidronate) to reduce bone pain and prevent fractures. (intelligentdental.com)
Atypical femur fractures (AFF) are newly defined and are a rare type of femoral trauma fracture possibly associated with extended bisphosphonate treatment. (autoaccident.com)
A study conducted in the February 23, 2011 issue of the Journal of the American Medical Association (JAMA) found that bisphosphonate (Boniva) use nearly triples the risk of atypical femur fractures in those who have taken the medication for longer than five years. (autoaccident.com)
The study concluded that bisphosphonate use and femur fractures are correlated. (autoaccident.com)
As researchers continue to study these drugs, they found that the correlation between bisphosphonate and atypical femur fractures continues to increase. (autoaccident.com)
BACKGROUND: Bisphosphonates are specific inhibitors of osteoclastic activity and used in the treatment of patients with multiple myeloma (MM). While bisphosphonates are shown to be effective in reducing vertebral fractures and pain, their role in improving overall survival (OS) remains unclear. (birmingham.ac.uk)
Since nobody agreed, I looked up bisphosphonates on Wikipedia , which said that after 3-5 years of treatment, BMD was maintained and fractures were reduced for 3-5 years afterward. (twgbreastcancer.com)
Bisphosphonates are also used to help maintain how dense your bones are and reduce the chance for bone fractures. (aernidental.com)
The general side effects and complications associated with bisphosphonates are esophageal or gastric irritation, atypical bone fractures, osteonecrosis of the jaws and ocular inflammation. (odontiatriko.gr)
Boniva had been used in a few patients with rare cases of Osteonecrosis of the Jaw (ONJ) and Atypical Fractures of the Femur. (cvbonehealth.com)
Bisphosphonates, for example, are linked to "atypical" fractures of the thigh bone and osteonecrosis of the jaw -- where bone tissue in the jaw begins to die. (blogspot.com)
Across studies of bisphosphonates, atypical thigh fractures happened in anywhere from two to 100 women for every 100,000 using the drugs, Crandall's team found. (blogspot.com)
The Archives of Internal Medicine published a study in May of 2012 that showed a link between bisphosphonate drugs and fractures. (tuckerinjurylawyer.com)

Bisphosphonates, including Actonel, may cause upper gastrointestinal disorders such as dysphagia, esophagitis and esophageal or gastric ulcers. (news-medical.net)
You might think that a MK4 supplement would be a lightweight compared to the widely prescribed bisphosphonate drugs, such as alendronate (Fosamax), risedronate (Actonel), raloxifene (Evista), and zoledronic acid (Zometa). (needs.com)
The beneficial drugs included bisphosphonates, sold under brand names such as Actonel (risedronate), Boniva (ibandronate) and Fosamax (alendronate), and the injection drugs denosumab (Prolia) and teriparatide (Forteo). (blogspot.com)

The 2014 update of a position paper from the American Association of Oral and Maxillofacial Surgeons recommended changing the name of bisphosphonate-related osteonecrosis of the jaw (BRONJ) to medication-related osteonecrosis of the jaw (MRONJ), owing to the increased number of maxillary and mandibular osteonecrosis cases that have been linked to other antiresorptive (denosumab) or antiangiogenic treatments. (medscape.com)
Among them, bisphosphonates (BPs), and denosumab (Dmab) are the more potent and more frequently used agents in everyday clinical practice. (medscape.com)
overall 2% of cancer patients treated with denosumab do developed jaw necrosis, which did not significantly different from the 1.45% incidence with Zometa. (malecare.org)
The investigators also concluded that there should be set up "International Prospective ONJ Registries of patients Treated with Bisphosphonates or Denosumab. (malecare.org)
As first-line treatment most patients are started with an antiresorptive treatment, i.e. drugs that inhibit osteoclast development and/or function (bisphosphonates, denosumab, oestrogens or selective oestrogen receptor modulators). (smw.ch)
For patients with advanced cancers involving bone, the standard of care for maintaining bone health is the use of antiresorptive therapies such as bisphosphonates, selective estrogen-receptor modulators, and denosumab. (jnccn.org)
Bisphosphonates and denosumab have been extensively studied both for prevention of bone loss due to cancer therapies and for prevention of skeletal-related events (SREs). (jnccn.org)
Duration of treatment with bisphosphonates and denosumab appears to modulate the risk of osteonecrosis of the jaw and atypical femur fracture (AFF). (jnccn.org)
Osteonecrosis of the jaw in patients treated with denosumab: a multicenter case series. (jomos.org)
Limones A, Sáez-Alcaide Lm, Díaz-Parreño Sa, Helm A, Bornstein Mm, Molinero-Mourelle P. Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab VS. zoledronic acid: a systematic review and meta-analysis. (jomos.org)
and bone targeted therapy (e.g., bisphosphonates and denosumab). (decisionsindentistry.com)
8 Sequential anti-resorptive therapy, such as bisphosphonates followed by denosumab or pamidronate followed by zoledronate, may lead to increased risk of MRONJ. (decisionsindentistry.com)
This study evaluates the knowledge and attitudes of a group of Colombian dentists regarding the risk of developing maxillary osteonecrosis with the use of bisphosphonates and denosumab. (revistadeosteoporosisymetabolismomineral.com)
50.3% of dentists mistakenly considered the use of bisphosphonates an absolute contraindication for major dental procedures and 51.3% believed the same regarding denosumab use. (revistadeosteoporosisymetabolismomineral.com)
74.6% of professionals would unnecessarily request approval from the referring physician to schedule procedures in patients receiving bisphosphonates and 43.8% for patients receiving denosumab. (revistadeosteoporosisymetabolismomineral.com)
The first related to the level of knowledge of dentists regarding the risk of developing ONJ with bisphosphonates and denosumab evaluated with general questions about the topic. (revistadeosteoporosisymetabolismomineral.com)

The F.D.A. review , published in The New England Journal of Medicine online on Wednesday, was prompted by a growing debate over how long women should continue using the drugs, known as bisphosphonates , which are sold as generic versions of brands like Fosamax and Boniva, as well as Novartis's Reclast. (drug-injury.com)
Studies have shown that bisphosphonates like Boniva can result in significant destruction of bone transformation. (autoaccident.com)
Boniva is one of the Bisphosphonates and has all of the potential benefits and risks of that class. (cvbonehealth.com)
There is not yet any conclusive evidence that Boniva, or any other Antiresorptive or Bisphosphonate, causes these conditions. (cvbonehealth.com)
Boniva is an Oral Bisphosphonate and has the same safety and effectiveness issues as others in this class. (cvbonehealth.com)
A class of drugs called bisphosphonates (whose brand names include Fosamax, Boniva, Reclast and Prolia) can inhibit resorption and help bring the two processes back into balance. (drchadbailey.com)

The symptoms of this are very similar to the symptoms of medication-related osteonecrosis of the jaw (MRONJ). (wikipedia.org)
Background: We investigated whether periodontal diseases contribute to the development of medication-related osteonecrosis of the jaw (MRONJ) in addition to tooth extraction, which is a major risk factor for MRONJ occurrence. (ewha.ac.kr)
Despite their clinical importance, the long-term use of bisphosphonates is linked to the onset of medication-related osteonecrosis of the jaw (MRONJ). (academicjournals.org)
American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw-2014 update. (jomos.org)
Newer targeted therapies are being linked with medication-related osteonecrosis of the jaw, which underscores the need to stay abreast of its risk factors and etiologies. (decisionsindentistry.com)
Describe risk factors for medication-related osteonecrosis of the jaw (MRONJ), including gender prevalence and anatomical sites most commonly affected. (decisionsindentistry.com)
2 While bisphosphonates, such as pamidronate, zoledronate and alendronate, are known to be associated with medication-related osteonecrosis of the jaw (MRONJ), newer targeted cancer therapies are being implicated in MRONJ, thereby necessitating dental providers to frequently update their knowledge base of this topic. (decisionsindentistry.com)
Human amniotic membrane: an improvement in the treatment of Medication-related osteonecrosis of the jaw (MRONJ)? (lucaguarda.it)

GGOH cell treatment reversed the negative effects of bisphosphonates on EPC. (nih.gov)
The biological effects of bisphosphonates are thought to be mainly associated with osteoclasts inhibition, whereas their effects on osteoblast function are unclear. (biomedcentral.com)
Our secondary objectives were to determine the effects of bisphosphonates on pain, quality of life, incidence of hypercalcemia, incidence of bisphosphonate-related gastrointestinal toxicities, osteonecrosis of jaw and hypocalcemia. (birmingham.ac.uk)
The more common side effects of bisphosphonates -- heartburn, muscle pain and throat irritation -- aren't serious. (blogspot.com)

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a condition found in patients who have received intravenous and oral forms of bisphosphonate therapy for various bone-related conditions. (medscape.com)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) manifests as exposed, nonvital bone involving the maxillofacial structures. (medscape.com)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is thought to be caused by trauma to dentoalveolar structures that have a limited capacity for bone healing due to the effects of bisphosphonate therapy. (medscape.com)
Computed tomography (CT) scanning and magnetic resonance imaging (MRI) may also be beneficial in the assessment of bisphosphonate-related osteonecrosis of the jaw (BRONJ). (medscape.com)
Surgical intervention for bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains limited because of the impaired ability of the bone to heal. (medscape.com)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is relatively new to the medical and dental literature. (medscape.com)
The true incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has yet to be determined. (medscape.com)
Several recent studies of patients with multiple myeloma and patients with breast cancer who received intravenous aminobisphosphonate therapy for metastatic bone lesions demonstrated 6-11% of the patients developed bisphosphonate-related osteonecrosis of the jaw (BRONJ). (medscape.com)
The incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been strongly correlated with the aminobisphosphonates pamidronate (Aredia) and zoledronic acid (Zometa) and is even higher in patients who have had recent dental extractions. (medscape.com)
Intravenous administration of bisphosphonates and nitrogenous bisphosphonates has the greatest side effects, including bisphosphonate-related osteonecrosis of the jaw (BRONJ). (saudiendodj.com)
Hereby, we reported a patient who was operated to treat the mandibular bisphosphonate-related osteonecrosis of the jaw (BRONJ) lesion. (wjps.ir)
The aim of this study was to elucidate the role of fibroblasts in bisphosphonate-related osteonecrosis of the jaw (BRONJ), evaluating the effect of zoledronate, alendronate, and ibandronate on the proliferation of fibroblasts and on their expression of genes essential for fibroblast physiology. (medsci.org)
2 ) The effectiveness of these drugs has been demonstrated by several studies , but they have also been associated with the development of BP-related osteonecrosis of the jaw (BRONJ). (medsci.org)
The aim of the present study was to elucidate the role of osteoblasts in bisphosphonates-related osteonecrosis of the jaw (BRONJ). (medsci.org)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an oral complication in which clinical and experimental studies are required to elucidate its pathogenesis and treatment, although there are much scientific knowledge since its first report. (fapesp.br)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an oral complication widely discussed in recent scientific literature. (fapesp.br)
PURPOSE: A previous case-control histomorphometric study showed higher odds of osteomalacia in patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ). (elsevier.com)
MATERIALS AND METHODS: BRONJ+ and BRONJ- patients treated with bisphosphonates were matched by sex (same) and age (within 5 years). (elsevier.com)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe adverse drug reaction, consisting of progressive bone destruction in the maxillofacial region of patients. (johsr.com)
The pathophysiological mechanism underlying Bisphosphonates related osteonecrosis of Jaw (BRONJ) remains poorly understood. (openrepository.com)
The aims of this study is to 1) prove the feasibility of in-vivo targeted removal of bisphosphonates from bone using chelating agents, and 2) use the targeted chelation to prevent BRONJ in rats. (openrepository.com)
Among these complications, Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ) attracts clinical attention because of it's difficult management and its pathogenesis still being unclear. (odontiatriko.gr)
Osteonecrosis of the Jaws (BRONJ). (odontiatriko.gr)
Related osteonecrosis of the jaw (bronj). (haircolorschile.com)

Consequently, these bisphosphonate-modified nanocarriers have synergistic effects in inhibition of malignancy progression and osteoclastogenic activity and compared to those mice treated with saline, whereas the mice treated with free alendronate plus paclitaxel caused significant loss of body weight. (mingsheng88.org)
Osteonecrosis of the jaw ONJ which can occur spontaneously, is generally associated with tooth extraction and/or local infection with delayed healing, and has been reported in patients taking bisphosphonates, including Alendronate sodium. (soxanddawgs.com)
Members of the bisphosphonate family that are in common clinical use comprise alendronate, zoledronate, risedronate, ibandronate, and pamidronate [ 15 ]. (biomedcentral.com)
Alendronate belongs to a class of drugs called bisphosphonates. (healthwarehouse.com)

The morbidity and lack of treatment response of this condition are serious facts to be considered when prescribing bisphosphonate therapy. (pucrs.br)
If the therapy with bisphosphonate is indicated, rigorous oral health adequacy must be performed and periodic evaluation of oral conditions is mandatory. (pucrs.br)
A thorough history and assessment of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered. (wikipedia.org)
An electronic systematic review has been prepared in the PubMed and manual verification from 2005 to 2020, according to the 2020 Prism Guidelines and using inclusion and exclusion criteria, under the terms: "Bisphosphonate AND root canal therapy" and "Bisphosphonate associated osteonecrosis of the jaw AND endodontics. (saudiendodj.com)
The first one includes endodontic treatment in patients with bisphosphonate therapy and its relationship with maxillary chemo-osteonecrosis. (saudiendodj.com)
The second includes recommendations to be followed in patients on bisphosphonate and root canal therapy. (saudiendodj.com)
All patients on bisphosphonate therapy should have the need for continued therapy re-evaluated on a periodic basis. (drugs.com)
It is typically associated with trauma to the jaw (tooth extraction), history of malignancy and/or infections while on bisphosphonate therapy. (rheumatology.org)
You may be able to discontinue therapy with bisphosphonates after 5 years of use if your fracture risk is low. (rheumatology.org)
Even though the causal romantic relationship between bisphosphonates and jaw osteonecrosisis are under analysis [31] 475489-16-8 still, increasingly more medical investigations show the solid association between bisphosphonate jaw and therapy osteonecrosis [32,33]. (mingsheng88.org)
Therefore, it's important to emphasize preventing jaw osteonecrosis during bisphosponate therapy. (mingsheng88.org)
In comparison to systemic administration of targeted delivery systems, calcium mineral phosphate biomaterial found in bone tissue medication delivery by regional implants can be an alternate approach for bone tissue regeneration and bone tissue restoration in bisphosphonate therapy. (mingsheng88.org)
Given the EBCTCG meta-analysis combined with the known benefits to bone health (an important complication of endocrine therapy among postmenopausal breast cancer patients), the medical oncology community has faced the question of whether or not to routinely recommend bisphosphonates in the adjuvant setting. (ascopost.com)
Osteonecrosis of jaw: post chemotherapy, radiation therapy or post-bisphosphonate--sometimes associated. (hopkinsguides.com)
Osteonecrosis of the jaw (ONJ) is a well-known devastating side effect of parenteral bisphosphonate therapy for cancer. (unimi.it)
Dental screening and adequate treatment are fundamental to reducing the risk of osteonecrosis in patients under antiresorptive or antiangiogenic therapy, or before initiating the administration. (johsr.com)
To evaluate the safety and efficacy of platelet-rich fibrin on wound healing and bone regeneration of tooth extraction in a patient receiving oral bisphosphonate therapy. (umin.ac.jp)
a patientreceiving oral bisphosphonate therapy for not less than 1 year. (umin.ac.jp)
Disease-specific risk for an osteonecrosis of the jaw under bisphosphonate therapy. (onlinesciencepublishing.com)
The saxon bisphosphonate register − therapy and prevention of bisphosphonate-related osteonecrosis of the jaws. (jomos.org)
OBJECTIVES: To assess the evidence related to benefits and harms associated with use of various types of bisphosphonates (aminobisphosphonates versus nonamino bisphosphonates) in the management of patients with MM. Our primary objective was to determine whether adding bisphosphonates to standard therapy in MM improves OS and progression-free survival (PFS), and decreases skeletal-related morbidity. (birmingham.ac.uk)
The patient must have current/previous treatment with antiresorptive or antiangiogenic drugs, with no history of radiation therapy or metastatic disease to the jaws. (decisionsindentistry.com)
There are differences in ONJ incidence with low-dose oral bisphosphonate therapy compared with high-dose intravenous bisphosphonate therapy. (redsdentists.org)
But if you are about to begin therapy with high doses of bisphosphonates, it's ideal to have a dental exam and resolve any oral disease before beginning the medication. (drchadbailey.com)
Additionally, serial bone scans are utilized to assess the patient's response to bisphosphonate therapy. (straightanursingstudent.com)
This endeavor has generated development leads that include: a preventative therapy for osteonecrosis of the jaw in oral surgery patients, bone selective antibiotics, and multiple imaging probes for the early diagnosis bone diseases. (biovinc.com)
Patients who were admitted with some sort of oral surgery, and patients who exhibited some sort of non-healing lesion in the jaw, all seemed to have one thing in common: a history of bisphosphonate therapy. (ftblaser.com)
The prevalence of ONJ in patients receiving long-term oral bisphosphonate therapy was reported to be 0.1% (10 cases per 10,000), which increased to 0.21% (21 cases per 10,000) in patients older than 4 years. (revistadeosteoporosisymetabolismomineral.com)

Dr. Robert Bunning, a rheumatologist at National Rehabilitation Hospital in Washington DC, said that in all of the 50 to 60 reported cases, most patients had been taking Fosamax or another type of bisphosphonate for more than five years. (lawyersandsettlements.com)
The USC School of Dentistry speculates that bisphosphonates-including Fosamax-- make it easier for bacteria to adhere to bone that is exposed after a tooth extraction or dental surgery, which leads to ONJ. (lawyersandsettlements.com)
Some researchers and pharmaceutical experts state that prevention and early treatment of patients using Fosamax is critical in the preservation of a healthy jaw bone. (lawyersandsettlements.com)
Individuals using Fosamax and other bisphosphonates should try to avoid tooth extractions and other major dental work while taking these medications. (lawyersandsettlements.com)
After controlling for referral bias, nine of 208 healthy School of Dentistry patients who take or have taken Fosamax for any length of time were diagnosed with osteonecrosis of the jaw (ONJ). (news-medical.net)
The next trial date for a Fosamax lawsuit involving jaw necrosis is scheduled to begin early next month. (aboutlawsuits.com)
Merck currently faces more than 1,100 Fosamax jaw lawsuits , most of which have been consolidated and centralized for pretrial proceedings in the U.S. District Court for the Southern District of New York as part of an MDL or multidistrict litigation. (aboutlawsuits.com)
There have already been several trials for Fosamax jaw necrosis lawsuits that have been held in the federal MDL over the last two years. (aboutlawsuits.com)
While Merck has successfully defended its medication in three cases, one lawsuit resulted in an $8 million jury award for Fosamax jaw damage last year, finding that Merck failed to adequately research the potential side effects of warn about the risk of jaw necrosis from Fosamax. (aboutlawsuits.com)
Osteonecrosis of the jaw is one of the most common reasons that people have elected to sue over Fosamax. (tuckerinjurylawyer.com)

Bisphosphonates have been linked with many other side effects, including esophagitis, esophageal cancer, osteonecrosis of the jaw, and atrial fibrillation. (nutrientrich.com)
And the latest research shows that these bone-building drugs can hurt your health, causing esophageal cancer, heart problems, osteonecrosis of the jaw, and even increased fracture risk! (needs.com)

Be aware that a low, but statistically significant increase in osteonecrosis of the jaw was seen among women receiving zoledronic acid. (medpagetoday.com)
On the other hand, patients getting zoledronic acid had an elevated risk of osteonecrosis of the jaw at 1.27%, compared with 0.31% for clodronate and 0.71% for ibandronate, a significant difference at P =0.003. (medpagetoday.com)
For the United States, the guideline means choosing between zoledronic acid infusions vs no adjuvant bisphosphonate. (ascopost.com)
There is also the problem of jaw osteonecrosis following prolonged use of bisphosphonates such as Aredia (pamidronate) and Zometa (zoledronic acid). (intelligentdental.com)
Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. (jbstjournal.com)
It did not report if ibandronic acid had a clinical advantage over other bisphosphonates.4 An analysis in the UK found that oral ibandronic acid is more cost-effective than intravenous pamidronate or zoledronic acid, but this could reflect the cost of infusions rather than greater efficacy.5 Comparative trials are needed. (pharmacologycorner.com)

abstract = "OBJECTIVES: To conduct a systematic review of epidemiological literature to determine the incidence of bisphosphonate related osteonecrosis of the jaw occurring either spontaneously or after dental surgery, in children and adolescents diagnosed with osteogenesis imperfecta.MATERIAL AND METHODS: MEDLINE, HMIC and EMBASE were used to search for English-language articles published from 1946 - 2013. (elsevier.com)

The most common concern for men taking Zometa and now Xgeva has been osteonecrosis of the jaw. (malecare.org)
One of the more common questions asked by many people is if osteonecrosis of the jaw is more or less common in men taking Zometa or Xgeva? (malecare.org)
Sept. 23 (Bloomberg) -- Novartis AG officials hid the health risks of the drugmaker's bone-strengthening medicines Aredia and Zometa, which a woman says destroyed her jaw, a lawyer told a New Jersey jury. (drug-injury.com)
A federal jury in New York weathered Hurricane Sandy to award a plaintiff almost $10.5 million after she developed necrosis of the jaw from taking Zometa. (wislawjournal.com)
Zometa contains bisphosphonate, which is intended to strengthen bones. (wislawjournal.com)
But although medical studies indicated in early 2003 that there was a link between Zometa and osteonecrosis of the jaw, the company failed to update the drug's labels until 2005, Davids claimed. (wislawjournal.com)
Vecchione called 17 other witnesses, including Davids' physicians, the two doctors who discovered the link between Zometa and jaw necrosis, and Novartis employees. (wislawjournal.com)
Vecchione also introduced some particularly damning evidence against the drug manufacturer: emails that indicated that Novartis tried to block a report connecting Zometa to jaw decay. (wislawjournal.com)

Specifically, patients with breast and prostate cancers taking Xgeva were twice as likely to develop osteonecrosis of the jaw as treated patients with other solid tumors or multiple myeloma! (malecare.org)
Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates. (jomos.org)
Bisphosphonates slow the gradual weakening of bones - a side-effect often endured by anyone with multiple myeloma. (answersmart.org)

However, recent research and clinical toxicity studies have reported that bisphosphonates have an inhibitory effect on 475489-16-8 osteoblastic function [28]. (mingsheng88.org)
Researchers at the University Of Southern California, School Of Dentistry release results of clinical data that links oral bisphosphonates to increased jaw necrosis. (news-medical.net)
Oral Bisphosphonate Use and the Prevalence of Osteonecrosis of the Jaw: An Institutional Inquiry" is the first large institutional study in the U.S. to investigate the relationship between oral bisphosphonate use and jaw bone death, said principal investigator Parish Sedghizadeh, assistant professor of clinical dentistry with the USC School of Dentistry. (news-medical.net)
The oncology community has now conducted several prospectively designed, hypothesis-driven randomized clinical trials among women with breast cancer to address this question: Do adjuvant bisphosphonates decrease the risk of breast cancer bone metastases and other recurrence? (ascopost.com)
If the public relations officer of a bisphosphonate manufacturer claims that there were no cases of Osteonecrosis of the Jaw (ONJ) in formal clinical trials (n=3000) what are the confidence limits for the rate of ONJ within the population (assuming no-cheating, proper followup, and real-world similarity of trial patients)? (blogspot.com)
Bisphosphonate coating of dental implants is a promising tool for surface modification aiming to improve the osseointegration process and clinical outcome. (biomedcentral.com)
Further studies are required to assess to which extent bisphosphonates coating might improve osseointegration in clinical situations. (biomedcentral.com)
The present chapter reviews history, classification, pharmacokinetics, clinical relevance and the mechanism of action of bisphosphonates. (odontiatriko.gr)
16. Yu X, Xu M, Xu S, Su Q. Clinical outcomes of giant cell tumor of bone treated with bone cement filling and internal fixation, and oral bisphosphonates. (jbstjournal.com)
To learn what you need to know for exams and clinical, let's go through bisphosphonates using the Straight A Nursing DRRUGS framework. (straightanursingstudent.com)

The first three reported cases of bisphosphonate-associated osteonecrosis of the jaw were spontaneously reported to the FDA by an oral surgeon in 2002, with the toxicity being described as a potentially late toxicity of chemotherapy. (wikipedia.org)
The FDA and drug manufacturer Novartis issued warnings to health professionals in September 2004 about the potential of ONJ due to the use of bisphosphonates in chemotherapy patients. (lawyersandsettlements.com)
Given the time ranges for starting bisphosphonates in the included trials, chemotherapy would have largely overlapped the bisphosphonate. (ascopost.com)
However, an undefined interaction between adjuvant chemotherapy and bisphosphonates might drive benefit, given we lack a clear mechanism for adjuvant bisphosphonate benefit (although the EBCTCG meta-analysis indicates a similar degree of benefit regardless of chemotherapy receipt). (ascopost.com)

Bisphosphonate medications help to preserve your bone density and bone strength. (rheumatology.org)
Bisphosphonate medications stay in your body for long periods of time even after stopping the medication. (rheumatology.org)
there are several medications that can help ease jaw pain and other symptoms of tmj disorders. (56blackmen.com)
Bisphosphonate medications work by evening out the balance between your osteoclasts and osteoblasts. (aernidental.com)
Pamidronate belongs to the family of medications known as bisphosphonates . (rxhealthmed.ca)
But for reasons that aren't fully understood, these medications sometimes have a different effect on the bones of the jaw. (drchadbailey.com)
The patient should have a dental exam prior to treatment and periodically as these medications can cause osteonecrosis of the jaw, especially if they have a current oral infection or prior history of tooth extraction, malignancy, or jaw trauma. (straightanursingstudent.com)

Bisphosphonates are suitable for metabolic bone diseases and malignant hypercalcemia. (saudiendodj.com)
Randomized phase II trial comparing different doses of the bisphosphonate ibandronate in the treatment of hypercalcemia of malignancy. (pharmacologycorner.com)

The decision about whether or not to take bisphosphonates depends on what your risk of a fracture is and how you feel about the pros and cons of your options. (mottchildren.org)
If you are at a higher risk of having a fracture, taking bisphosphonates is more likely to help you prevent a fracture. (mottchildren.org)
Prior to the publication of the studies, the Food and Drug Administration (FDA) first issued an alert to physicians in January 2010 concerning the possibility of severe bone fracture related to bisphosphonate treatment. (autoaccident.com)

Ninety-five percent of cancer patients after getting high-dose intravenous bisphosphonates created jaw osteonecrosis [30]. (mingsheng88.org)

Bisphosphonates are antiresorptive drugs that influence bone metabolism mainly via inhibition of osteoclast recruitment, differentiation, and bone resorption activity [ 13 ]. (biomedcentral.com)

There were also concerns that long-term use of bisphosphonates might result in over-suppression of bone turnover (this is what my endocrinologist referred to). (twgbreastcancer.com)

therefore, periodontal diseases should be proactively managed in patients taking bisphosphonates. (ewha.ac.kr)

In a formal discussion of Gralow's paper, he noted that a meta-analysis by the Early Breast Cancer Trialists' Collaborative Group , now in press, found that treatment with bisphosphonates was associated with a 33% reduction in bone metastases and an 18% reduction in the risk of death. (medpagetoday.com)
Bisphosphonates for the prevention of bone metastases. (ijbcp.com)
A Cochrane review has concluded that bisphosphonates are effective treatment for the bony metastases of breast cancer, although they have no effect on survival. (pharmacologycorner.com)

Bisphosphonate use is associated with a significant increase in the risk of serious atrial fibrillation in postmenopausal women. (greenmedinfo.com)
Patients who were administered intravenous or intraoral bisphosphonates for more than 4 years with associated risk factors are more predisposed to chemo-osteonecrosis of the jaw. (saudiendodj.com)
Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. (semanticscholar.org)
There is a rare risk of developing jaw or tooth pain, called osteonecrosis of the jaw . (rheumatology.org)
Is vitamin D deficiency a risk factor for osteonecrosis of the jaw in patients with cancer? (elsevier.com)
The study's results are in contrast to drug makers' prior assertions that bisphosphonate-related ONJ risk is only noticeable with intravenous use of the drugs, not oral usage, Sedghizadeh said. (news-medical.net)
We've been told that the risk with oral bisphosphonates is negligible, but four percent is not negligible," he said. (news-medical.net)
Most doctors who have prescribed bisphosphonates have not told patients about any oral health risks associated with the use of the drugs, despite even short-term usage posing a risk due to the drug's tenacious 10-year half life in bone tissue. (news-medical.net)
Long-term use of oral bisphosphonates has been linked to an increased risk of serious and debilitating jaw problems, known as osteonecrosis of the jaw . (aboutlawsuits.com)
Known risk factors for osteonecrosis of the jaw include invasive dental procedures e. (soxanddawgs.com)
Use of oral bisphosphonates and risk of hospital admission with osteonecrosis of the jaw: Large prospective cohort study in UK women. (ox.ac.uk)

Ibandronate Sodium Tablets, like other bisphosphonates administered orally, may cause local irritation of the upper gastrointestinal mucosa. (drugs.com)
EPC were incubated with different nitrogen (N-BPs: ibandronate, pamidronate, zoledronate) and a non-nitrogen-containing bisphosphonates (NN-BP: clodronate) with and without GGOH. (nih.gov)

citation needed] The International Myeloma Foundation's web-based survey included 1203 respondents, 904 patients with myeloma and 299 with breast cancer and an estimate that after 36 months, osteonecrosis of the jaw had been diagnosed in 10% of 211 patients on zoledronate and 4% of 413 on pamidronate. (wikipedia.org)
To explain this heterogeneity we performed a metaregression assessing the relationship between bisphosphonate potency and improvement in OS, which found indicating an OS benefit with zoledronate (P = 0.058). (birmingham.ac.uk)
However, there was no difference between zoledronate and other bisphosphonates. (birmingham.ac.uk)

Osteonecrosis of the jaw (ONJ) is a rare but severe condition manifested as necrotic bone lesion or lesions of the jaws. (medscape.com)
Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). (wikipedia.org)
There have been reports of severe and occasionally incapacitating bone, joint and/or muscle pain in patients taking bisphosphonates. (news-medical.net)
I had become very ill for about 15 months with symptoms of facial numbness, severe fatigue, blood pressure issues and feeling like there was a huge lump sewn into my jaw. (oralsurgeryarizona.com)
Tell your doctor right away if you have any serious side effects, including: jaw pain, increased or severe bone/joint/muscle pain, new or unusual hip/thigh/groin pain, swelling of joints/hands/ankles/feet, black/tarry stools, vomit that looks like coffee grounds. (healthwarehouse.com)

Intraoral examination revealed denuded necrotic bone bilaterally on the posterior aspect of both the jaws (Figures 1-3). (who.int)
Materials and methods: Eight patients who underwent radiotherapy for the treatment of cervical or neck cancer were diagnosed with ORN of the jaws at our Department, for a total of 11 sites of necrotic bone exposure (3 patients were diagnosed with more than one site of osteoradionecrosis). (thejcdp.com)

A connection was discovered between the class of drugs known as bisphosphonates and a serious bone condition called Osteonecrosis of the Jaw (ONJ). (lawyersandsettlements.com)

Pain and neuropathy Erythema and suppuration Bad breath Post radiation maxillary bone osteonecrosis is something that is found more in the lower jaw (mandible) rather than the maxilla (upper jaw) this is because there are many more blood vessels in the upper jaw. (wikipedia.org)

OBJECTIVES: To conduct a systematic review of epidemiological literature to determine the incidence of bisphosphonate related osteonecrosis of the jaw occurring either spontaneously or after dental surgery, in children and adolescents diagnosed with osteogenesis imperfecta. (elsevier.com)
Inclusion criteria consisted of population based studies of children and adolescents (24 years and younger) diagnosed with osteogenesis imperfecta, only studies which included a dental examination, and patients treated with intravenous bisphosphonates were included. (elsevier.com)
CONCLUSIONS: There is no evidence to support hypothesis of causal relationship between bisphosphonates and osteonecrosis of the jaw in children and adolescents with osteogenesis imperfecta. (elsevier.com)
More prospective studies on bisphosphonate use in osteogenesis imperfecta needs to be carried out. (elsevier.com)
Additionally, you may see bisphosphonates used off-label for osteogenesis imperfecta in both pediatric and adult patients. (straightanursingstudent.com)

Signs of jaw osteonecrosis include gum swelling, jaw pain, a sore on the gums and tooth loosening. (sunjournal.com)
Osteonecrosis of the jaw (ONJ) is a disease in which bone tissue in the jaw does not heal after minor traumas such as tooth extraction or oral surgery. (lawyersandsettlements.com)
The danger is especially pronounced with procedures that directly expose the jaw bone, such as tooth extractions and other oral surgery. (news-medical.net)
Tooth decay with cavities (dental caries) can cause a toothache, sensitivity of the tooth to cold, heat, sweet foods or pressure and, occasionally, localized jaw pain [36] . (ehealthstar.com)
A tooth crown that sits too high can cause an uneven bite, which can result in the persistent jaw or ear pain [16] . (ehealthstar.com)
A tooth abscess or granuloma can cause throbbing pain, tenderness and swelling in the gum and jaw [13] . (ehealthstar.com)
An impacted wisdom tooth can cause pain, tenderness and swelling of the gum and jaw pain during mouth opening [12] . (ehealthstar.com)
Jaw pain after wisdom tooth extraction can be due to inflammation called "dry socket" (throbbing pain, usually from the 3rd to 5th day) or a nerve injury (numbness in the gums, tongue or chin lasting up to several weeks) [37] . (ehealthstar.com)
Lodi G, Sardella A, Salis A, Demarosi F, Tarozzi M, Carrassi A. Tooth extraction in patients taking intravenous bisphosphonates: a preventive protocol and case series. (jomos.org)
However, doctors recommend taking care of any potential teeth issues (cavities, jaw surgery, tooth removal) before taking these drugs. (answersmart.org)
If you are a candidate for oral surgery, tooth extraction or implant placement, it's important to consider the possible effect of bisphosphonate use before you have this type of procedure. (drchadbailey.com)
In the case of dental implant placement, the decision to proceed is made on an individual basis, after a thorough examination of the quality and quantity of tooth-supporting bone in the jaw. (drchadbailey.com)

Luckily, with treatment as well as the rigorous oral hygiene regimen USC dentists developed especially for patients with a history of bisphosphonate usage, the remaining sites slowly but fully healed. (news-medical.net)

Due to its mechanism of action, Marx [3] , [4] warned of a new complication, bisphosphonate-related maxillary chemo-osteonecrosis, in 2003. (saudiendodj.com)
Van den Wyngaert noted in the introduction to the data section of the poster that although jaw necrosis is an uncommon complication in cancer, patients who develop it have few effective treatment options, making avoidance a consideration in the use of anti-resorptive agents. (malecare.org)
Even if the number of cases of ONJ in patients taking oral bisphosphonates are still rare compared to the total exposure, rheumatologists treating bone diseases with bisphosphonates must be aware of this new complication, allowing for prevention and early diagnosis. (unimi.it)
It is uncommon for rheumatologists to ask about dental problems but this new bisphosphonate-associated complication highlights the need for this to change. (unimi.it)
In this paper we review the literature available on this newly described bisphosphonate-induced complication with particular emphasis on ONJ cases related to the use of oral bisphosphonates. (unimi.it)
Jaw osteonecrosis related to the use of bisphosphonate is a common complication that adversely affects quality of life, producing significant morbidity in patients affected injuring the metabolism of bone repair. (ufu.br)
Background: Osteonecrosis (ON) is a prevalent (30-50% by age 30) yet underdiagnosed complication in patients with sickle cell disease (SCD), commonly affecting the femoral and humeral head. (onescdvoice.com)

Bisphosphonates have been widely prescribed for treatment of diseases characterized by intense bone resorption. (pucrs.br)
Fosomax is the most widely prescribed oral bisphosphonate, ranking as the 21st most prescribed drug on the market since 2006, according to a 2007 report released by IMS Health. (news-medical.net)

Implications of endodontic treatment in chemo-osteonecrosis of the maxillary jaw due to bisphosphonates. (saudiendodj.com)

Osteonecrosis of the jaw is primarily associated with high-dose bisphosphonate use in cancer patients. (medscape.com)

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These drugs have also been associated with a serious side effect, avascular osteonecrosis of the jaws. (pucrs.br)
Women who are treated with AIs are also usually treated with drugs such as bisphosphonates to prevent bone loss. (twgbreastcancer.com)
Alcohol abuse, drugs, and smoking are usually contributing factors as well in the development of bisphosphonate osteonecrosis. (aernidental.com)
The practitioners who commonly prescribe bisphosphonates, should be aware of the complications of these drugs which may strongly diminish the quality of life of the patiens. (odontiatriko.gr)
Bisphosphonates are a pharmacologic class of drugs used to treat disorders of the bone by inhibiting osteoclast activity. (straightanursingstudent.com)
As mentioned, bisphosphonates are very useful drugs in the treatment of certain metabolic bone diseases. (itmedicalteam.pl)
These include antihypertensive drugs, oral hypoglycemic agents/insulin, hormones (corticosteroid, thyroxin, and tamoxifen), and anti-resorptive agents including bisphosphonates and anti-angiogenic agents. (jdionline.org)

A meta-analysis 1 by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) pooling data from more than 18,000 women from ABCSG-12, 2 AZURE, 3 and 24 other trials demonstrated significant benefits for the use of adjuvant bisphosphonates in early-stage breast cancer. (ascopost.com)
This guideline will mean discussing adjuvant bisphosphonates with a healthy 53-year-old postmenopausal woman with T2-N0 hormone receptor-positive breast cancer. (ascopost.com)
The addition of adjuvant bisphosphonates for such patients might yield at most a further 1% to 2% absolute reduction in the risks of distant recurrence and cancer mortality. (ascopost.com)
For instance, the primary endpoint of AZURE was not met, but further analyses suggested that benefit from adjuvant bisphosphonates might accrue to women who had been in menopause for more than 5 years. (ascopost.com)
nevertheless, it will be interesting to see how insurance coverage for adjuvant bisphosphonates plays out. (ascopost.com)
Adjuvant bisphosphonates improve disease outcomes in postmenopausal early breast cancer (EBC) but the long-term effects are poorly described. (ub.edu)

Methods: Searches were conducted using the following search concepts: (sickle cell disease OR sickle cell anemia OR hemoglobin SC disease) AND (osteonecrosis OR avascular necrosis OR bone and joint complications) NOT Bisphosphonate-Associated Osteonecrosis of the Jaw. (onescdvoice.com)

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Bisphosphonates in the management of Paget's disease. (ijbcp.com)

They seem to be more likely if women take bisphosphonates for more than 5 years. (mottchildren.org)
The reason he wanted the higher dose was that, as well as helping protect bones, there is also a documented reduction in cancer recurrence in postmenopausal women with early stage breast cancer when they take bisphosphonates. (twgbreastcancer.com)

But after taking the drug for one and half years Davids developed necrosis of the jaw, or bone decay, with dead bones literally falling out of her mouth, he said. (wislawjournal.com)
The endocrinologist thought the dose that the integrative oncologist recommended was too high and might cause me to get side effects such as necrosis of the jaw and suppressed bone turnover. (twgbreastcancer.com)

Manzano-Moreno FJ, Ramos-Torrecillas J, Melguizo-Rodríguez L, Illescas-Montes R, Ruiz C, García-Martínez O. Bisphosphonate Modulation of the Gene Expression of Different Markers Involved in Osteoblast Physiology: Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw. (medsci.org)
A potential of bisphosphonate coated surfaces to stimulate osteoblast differentiation was investigated by several in vitro studies with contradictory results. (biomedcentral.com)

Osteonecrosis of the jaw is a disease in which bone tissue in the jaw does not heal after minor traumas. (lawyersandsettlements.com)

In vitro studies that assessed alkaline phosphatase activity in osteoblasts following cell culture on bisphosphonate coated titanium surfaces were searched in electronic databases PubMed/MEDLINE, Scopus and ISI Web of Science. (biomedcentral.com)

The use of bisphosphonates is regularly indicated for conditions related to cancer and metabolic bone diseases, acting mainly in inhibiting osteoclastic activity and consequently inhibiting bone resorption. (ufu.br)

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A 60-year-old male patient was referred for dental consultation by a physician following bone necrosis of jaw bones. (who.int)
At that appointment she presented with the history of the recent dental treatment she received from Dr. R. She described how Dr. R had told her that her occlusion (bite) was the major reason for her jaw pain. (experts.com)
Dental work that involves prolonged mouth opening or an injection can cause jaw pain, which should subside in a day or two. (ehealthstar.com)
Swollen lymph nodes that appear as painful lumps below the jaw can be due to infections, such as a dental abscess, strep throat [20] , infectious mononucleosis and cat-scratch disease (Bartonella henselae) [43] . (ehealthstar.com)
Dual-degree oral surgeon Dr. Wessel brings a wealth of knowledge to Carolinas Center for Oral & Facial Surgery and specializes in dental implant-supported restorations , wisdom teeth , jaw surgery , TMJ dysfunction , obstructive sleep apnea , and facial trauma . (mycenters.com)
Dr. Wessel brings wide-ranging experience to Carolinas Center for Oral & Facial Surgery, with surgical interests including the treatment of impacted wisdom teeth , replacing missing or broken teeth with dental implants , jaw misalignment , obstructive sleep apnea , TMJ dysfunction , and facial trauma . (mycenters.com)
In about 60% of cases, the ONJ seems to have been triggered by dental surgery involving the jaw bone. (twgbreastcancer.com)
It is now recommended that patients postpone bisphosphonate treatment until after all needed dental work is finished. (twgbreastcancer.com)
I asked my integrative oncologist about ONJ, and he said that the main thing is to avoid dental work while I am on bisphosphonates. (twgbreastcancer.com)
This type of osteonecrosis is located in the jaw, also known as jaw osteonecrosis, which results from dental implants. (aernidental.com)
The dentist said during training in dental school he had worked with many patients with ON of the Jaw. (osteonecrosis.me)
They should also have a dental check-up before treatment because of the association between bisphosphonates and osteonecrosis of the jaw. (pharmacologycorner.com)

Anatomy21

Organisms1

Diseases40

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology2

Phenomena and Processes15

Information Science1

Health Care6

Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience. (1/45)

Taking the lead: sharing best practice in intravenous bisphosphonate use in urological cancers. (2/45)

CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma. (3/45)

Extraction socket healing in rats treated with bisphosphonate: animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients. (4/45)

Bisphosphonate-related osteonecrosis of the jaws. (5/45)

Antibiotic effects on bacterial profile in osteonecrosis of the jaw. (6/45)

A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosis. (7/45)

Use of cone-beam computerized tomography for evaluation of bisphosphonate-associated osteonecrosis of the jaws in an experimental rat model. (8/45)

Osteonecrosis

Jaw

Diphosphonates

Jaw Diseases

Bisphosphonate-Associated Osteonecrosis of the Jaw

Femur Head Necrosis

Bone Density Conservation Agents

Alendronate

Etidronic Acid

Femur Head

Imidazoles

Clodronic Acid

Osteoporosis

Bone Neoplasms

Osteoporosis, Postmenopausal

Maxillary Diseases

Osteitis Deformans

Mandibular Diseases

Bone Remodeling

Jaw Neoplasms

Tooth Extraction

Bone Resorption

Humerus

Bone Density

Jaw Abnormalities

Femur

Hypercalcemia

Femoral Fractures

Bone and Bones

Fractures, Bone

Mandible

Fractures, Stress

Osteolysis

Osteocytes

Bone Diseases

Bone Transplantation

Tooth Socket

Tantalum

Glucocorticoids

Methylprednisolone

Fibula

Hip Joint

Teriparatide

Geranyltranstransferase

Bone Diseases, Metabolic

Treatment Outcome

Fractures, Spontaneous

Metal-on-Metal Joint Prostheses

Administration, Oral

Hip Fractures

Osteoporotic Fractures

Retrospective Studies

Decalcification Technique

Arthroplasty, Replacement, Hip

Magnetic Resonance Imaging

Osteoclasts

Time Factors

Masticatory Muscles

Dental Prophylaxis

Osteotomy

Multiple Myeloma

Durapatite

Bone Matrix

Orthopedic Procedures

Dromaiidae

Risk Factors

Blood Coagulation Disorders, Inherited

Tibia

Epiphyses

Osteoradionecrosis

Femoral Neck Fractures

Diaphyses

Follow-Up Studies

Drug Administration Schedule

Alkaline Phosphatase

Arthralgia

Jaw, Edentulous

Osteogenesis

Bone Demineralization, Pathologic

Decompression, Surgical