Bisbenzimidazole
CCAAT-Binding Factor
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Promoter Regions, Genetic
Base Sequence
Transcription, Genetic
Transcription Factors
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Microwaves
Cyclization
Anthelmintics
Mebendazole
Antinematodal Agents
Albendazole
Directories as Topic
Succinic Anhydrides
Hydrogenation
Proline
Molecular Structure
Antiviral Agents
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Computer Security
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Privacy
Software
Internet
Databases, Factual
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Mitosis
Cell Division
S Phase
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Mutation
Eukaryotic Cells
Encyclopedias as Topic
Glass
Fixatives
Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.
Microtomy
Waxes
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
Formaldehyde
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Forensic Genetics
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Sensitivity and Specificity
Silicon Dioxide
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
DNA Primers
Publishing
Journalism, Medical
Journal Impact Factor
Bibliometrics
Editorial Policies
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Identification and characterization of genes required for hyphal morphogenesis in the filamentous fungus Aspergillus nidulans. (1/182)
In the filamentous fungus Aspergillus nidulans, germination of an asexual conidiospore results in the formation of a hyphal cell. A key feature of spore germination is the switch from isotropic spore expansion to polarized apical growth. Here, temperature-sensitive mutations are used to characterize the roles of five genes (sepA, hypA, podB-podD) in the establishment and maintenance of hyphal polarity. Evidence that suggests that the hypA, podB, and sepA genes are required for multiple aspects of hyphal morphogenesis is presented. Notably, podB and sepA are needed for organization of the cytoskeleton at sites of polarized growth. In contrast, podC and podD encode proteins that appear to be specifically required for the establishment of hyphal polarity during spore germination. The role of sepA and the pod genes in controlling the spatial pattern of polarized morphogenesis in germinating spores is also described. Results obtained from these experiments indicate that the normal pattern of germ-tube emergence is dependent upon the integrity of the actin cytoskeleton. (+info)The effect of mannitol versus dimethyl thiourea at attenuating ischemia/reperfusion-induced injury to skeletal muscle. (2/182)
OBJECTIVE: Mannitol is used as a treatment for skeletal muscle ischemia/reperfusion (I/R) injury in humans, despite the fact that its effectiveness in vivo is still disputed. The purpose of this study was to determine the efficacy of mannitol in attenuating I/R injury at the microcirculatory level. METHODS: The study was designed as an experimental study with male Wistar rats. The main outcome measures were intravital microscopy, which was used to measure capillary perfusion, capillary and venular red blood cell velocity (VRBC), and leukocyte-endothelial interactions in the extensor digitorum longus muscle of the rat hind limb before and after ischemia. In addition, tissue injury was assessed during reperfusion with the fluorescent vital dyes bisbenzimide and ethidium bromide. Dimethyl thiourea (DMTU), a highly effective therapeutic agent of experimental I/R injury, was used as a positive control. RESULTS: No-flow ischemia (2 hour) resulted in a 40% drop in capillary perfusion, a decline in capillary and venular VRBC, and increased leukocyte venular adherence and tissue infiltration. Tissue injury increased to a constant level during reperfusion. Mannitol attenuated capillary malperfusion during the first 60 minutes of reperfusion and prevented a decline in capillary VRBC. However, mannitol did not reduce tissue injury or leukocyte adherence and infiltration during reperfusion. By comparison, DMTU not only prevented the perfusion deficits and the increases in leukocyte venular adherence and tissue infiltration but significantly reduced the magnitude of tissue injury. CONCLUSION: Our findings suggest that mannitol may be of limited value for the prevention of early reperfusion-induced injury after no-flow ischemia in skeletal muscle. By comparison, DMTU was highly efficacious by not only reducing microvascular perfusion deficits but by also reducing leukocyte-endothelial cell interactions and the incidence of cellular injury. (+info)DNA minor groove recognition by bis-benzimidazole analogues of Hoechst 33258: insights into structure-DNA affinity relationships assessed by fluorescence titration measurements. (3/182)
Fluorescence titration measurements have been used to examine the binding interaction of a number of analogues of the bis -benzimidazole DNA minor groove binding agent Hoechst 33258 with the decamer duplex d(GCAAATTTGC)2. The method of continuous variation in ligand concentration (Job plot analysis) reveals a 1:1 binding stoichiometry for all four analogues; binding constants are independent of drug concentration (in the range [ligand] = 0.1-5 microM). The four analogues studied were chosen in order to gain some insight into the relative importance of a number of key structural features for minor groove recognition, namely (i) steric bulk of the N -methylpiperazine ring, (ii) ligand hydrophobicity, (iii) isohelicity with the DNA minor groove and (iv) net ligand charge. This was achieved, first, by replacing the bulky, non-planar N -methylpiperazine ring with a less bulky planar charged imidazole ring permitting binding to a narrower groove, secondly, by linking the N -methylpiperazine ring to the phenyl end of the molecule to give the molecule a more linear, less isohelical conformation and, finally, by introducing a charged imidazole ring in place of the phenolic OH making it dicationic, enabling the contribution of the additional electrostatic interaction and extended conformation to be assessed. Delta G values were measured at 20 degrees C in the range -47.6 to -37.5 kJ mol-1 and at a number of pH values between 5.0 and 7.2. We find a very poor correlation between Delta G values determined by fluorescence titration and effects of ligand binding on DNA melting temperatures, concluding that isothermal titration methods provide the most reliable method of determining binding affinities. Our results indicate that the bulky N -methylpiperazine ring imparts a large favourable binding interaction, despite its apparent requirement for a wider minor groove, which others have suggested arises in a large part from the hydrophobic effect. The binding constant appears to be insensitive to the isohelical arrangement of the constituent rings which in these analogues gives the same register of hydrogen bonding interactions with the floor of the groove. (+info)Progesterone promotes the acrosome reaction in capacitated human spermatozoa as judged by flow cytometry and CD46 staining. (4/182)
The acrosome reaction is a necessary prerequisite for spermatozoa to acquire fertilizing ability. Several different moieties appear to promote the acrosome reaction through different pathways, including solubilized zona pellucidae, recombinant zona protein ZP3, follicular fluid, calcium ionophores, and mannosylated bovine serum albumin (BSA). Although many investigators have presented evidence that progesterone also promotes the acrosome reaction through the mediation of a non-genomic cell membrane receptor, this concept has been challenged. Other workers have suggested that progesterone does not promote an acrosome reaction in human spermatozoa, as judged by the detection of CD46, a complement regulatory protein present on the inner acrosome membrane, through flow cytometric analysis of large numbers of spermatozoa. Prior investigations were criticized by the limited numbers of spermatozoa enumerated visually, the use of non-specific staining techniques, and the failure to eliminate dead spermatozoa during the scoring of the acrosome reaction. We have repeated these experiments, using both a supravital dye to eliminate dead spermatozoa from flow cytometric analysis, and anti-CD46 monoclonal antibody to score acrosome-reacted spermatozoa. Care was taken to validate the adequacy of capacitation conditions, which were proven by the ability of spermatozoa to acrosome react in response to mannosylated BSA and to penetrate zona-free hamster eggs. Confocal microscopy was used to confirm that CD46 immunostaining was limited to the acrosomal region of the spermatozoon head. Our results indicate that progesterone does promote an acrosome reaction within capacitated spermatozoa. (+info)Autosomal trisomy 20 (61,XX,+20) in a malformed bovine fetus. (5/182)
A 240-day-gestation female bovine fetus with severe anasarca, palatoschisis, cheiloschisis, mild cranioschisis, and a flattened facies was collected at a slaughterhouse, and a fibroblast line was established from the fetal skin. Chromosome preparations were Q-banded, and chromosome counts were taken that indicated the presence of 61 chromosomes in cells of the fetus (the normal diploid number for domestic cattle is 60). Q-band karyotypes were constructed, and Q-band analysis revealed the presence of three copies of chromosome 20. Trisomy 20 (61,XX,+20) was confirmed through the use of two-color fluorescence in situ hybridization of bovine bacterial artificial chromosome clones that were specific to chromosome 20 and the X chromosome. (+info)Massive parallel analysis of DNA-Hoechst 33258 binding specificity with a generic oligodeoxyribonucleotide microchip. (6/182)
A generic oligodeoxyribonucleotide microchip was used to determine the sequence specificity of Hoechst 33258 binding to double-stranded DNA. The generic microchip contained 4096 oxctadeoxynucleo-tides in which all possible 4(6)= 4096 hexadeoxy-nucleotide sequences are flanked on both the 3'- and 5'-ends with equimolar mixtures of four bases. The microchip was manufactured by chemical immobilization of presynthesized 8mers within polyacrylamide gel pads. A selected set of immobilized 8mers was converted to double-stranded form by hybridization with a mixture of fluorescently labeled complementary 8mers. Massive parallel measurements of melting curves were carried out for the majority of 2080 6mer duplexes, in both the absence and presence of the Hoechst dye. The sequence-specific affinity for Hoechst 33258 was calculated as the increase in melting temperature caused by ligand binding. The dye exhibited specificity for A:T but not G:C base pairs. The affinity is low for two A:T base pairs, increases significantly for three, and reaches a plateau for four A:T base pairs. The relative ligand affinity for all trinucleotide and tetranucleotide sequences (A/T)(3)and (A/T)(4)was estimated. The free energy of dye binding to several duplexes was calculated from the equilibrium melting curves of the duplexes formed on the oligonucleotide microchips. This method can be used as a general approach for massive screening of the sequence specificity of DNA-binding compounds. (+info)Synergistic cytotoxicity and apoptosis by Apo-2 ligand and adriamycin against bladder cancer cells. (7/182)
Resistance to conventional anticancer chemotherapeutic agents remains one of the major problems in the treatment of bladder cancer. Hence, new therapeutic modalities are necessary to treat the drug-resistant cancers. Apo-2 ligand (Apo-2L) is member of the tumor necrosis factor ligand family, and it induces apoptosis in cancer cells. Several cytotoxic anticancer drugs, including Adriamycin (ADR), also mediate apoptosis and may share the common intracellular pathways leading to cell death. We reasoned that combination treatment of the drug-resistant cancer cells with Apo-2L and drugs might overcome their resistance. Here, we examined whether bladder cancer cells are sensitive to Apo-2L-mediated cytotoxicity and whether Apo-2L can synergize with ADR in cytotoxicity and apoptosis against bladder cancer cells. Recombinant human soluble Apo-2L (sApo-2L), which carries the extracellular domain of Apo-2L, was used as a ligand. Cytotoxicity was determined by a 1-day microculture tetrazolium dye assay. Synergy was assessed by isobolographic analysis. Human T24 bladder cancer line was relatively resistant to sApo-2L. Treatment of T24 line with combination of sApo-2L and ADR resulted in a synergistic cytotoxic effect. Synergy was also achieved in the ADR-resistant T24 line (T24/ADR), two other bladder cancer lines, and three freshly derived human bladder cancer cell samples. In addition, T24 cells were sensitive to treatment with sApo-2L combined with epirubicin or pirarubicin. The synergy achieved in cytotoxicity with sApo-2L and ADR was also achieved in apoptosis. Intracellular accumulation of ADR was not affected by sApo-2L. Incubation of T24 cells with sApo-2L down-regulated the expression of glutathione S-transferase-pi mRNA. This study demonstrates that combination treatment of bladder cancer cells with sApo-2L and ADR overcomes their resistance. The sensitization obtained with established ADR-resistant bladder cancer cells and freshly isolated bladder cancer cells required low subtoxic concentrations of ADR, thus supporting the in vivo potential application of combination of sApo-2L and ADR in the treatment of ADR-resistant bladder cancer. (+info)DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes. (8/182)
Bis(hydroxy)salen.Fe complexes were designed as self-activated chemical nucleases. The presence of a hy-droxyl group on the two salicylidene moieties serve to form a hydroquinone system cooperating with the iron redox system to facilitate spontaneous formation of free radicals. We compared the DNA binding and cleaving properties of the ortho -, meta- and para -(bishydroxy) salen.Fe complexes with that of the corresponding chelate lacking the hydroxyl groups. DNA melting temperature studies indicated that the para complex exhibits the highest affinity for DNA. In addition, this para compound was considerably more potent at cleaving supercoiled plasmid DNA than the regio-isomeric ortho - and meta -hydroxy-salen.Fe complexes, even in the absence of a reducing agent, such as dithiothreitol used to activate the metal complex. The DNA cleaving activity of the para isomer is both time and concentration dependent and the complexed iron atom is absolutely essential for the sequence uniform cleavage of DNA. From a mechanistic point of view, electron spin resonance measurements suggest that DNA contributes positively to the activation of the semi-quinone system and the production of ligand radical species responsible for subsequent strand scission in the absence of a reducing agent. The para -hydroxy-salen.Fe complex has been used for detecting sequence-specific drug-DNA interactions. Specific binding of Hoechst 33258 to AT sequences and chromomycin to GC sequences were shown. The para -bis(hydroxy)salen.Fe derivative complements the tool box of footprinting reagents which can be utilised to produce efficient cleavage of DNA. (+info)
Naphthalenediimide-Linked Bisbenzimidazole Derivatives
as Telomeric G‑Quadruplex-Stabilizing Ligands with Improved
Anticancer...
ChemIDplus - 23491-44-3 - INAAIJLSXJJHOZ-UHFFFAOYSA-N - Bisbenzimidazole - Similar structures search, synonyms, formulas,...
Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs
Structure Cluster
- 1D65: MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER...
RCSB PDB
- 117D: CRYSTAL AND MOLECULAR STRUCTURE OF THE ALTERNATING DODECAMER D(GCGTACGTACGC) IN THE A-DNA FORM:...
Cytotoxicity of hoechst staining in overnight experiment - Cell Biology - BioForum
Minor Groove Binders and Drugs Targeting Proteins Cover Complementary Regions in Chemical Shape Space | ChemAxon
Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium...
Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimers disease ...
Patente US20030087431 - Composite blastocysts (CBs) from aggregates of dissociated cells of non ... - Google Patentes
British Library EThOS: Synthesis of novel oligomeric bis-benzimidazoles for their biological evaluation
52nd asms conference abstracts listing
Terminal lipophilization of a unique DNA dodecamer by various nucleolipid headgroups: Their incorporation into artificial lipid...
DNA-Complexes with Drugs and Proteins
DAPI/Hoechst vital staining - Flow Cytometry - BioForum
1G3X INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER | 1G3X I | P15056 | BRAF | Serine/threonine-protein kinase B...
Workshop Conference Hoechst (18th 1987 Schloss Ringberg) | Open Library
Top 10 Hotels in Hoechst, Germany | Hotels.com
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Binding Properties of Large Antiviral Polyamides (PA1 and PA25) and Na by Elena Vasilieva
Bis-benzimidazole derivatives as hepatitis c virus inhibitors
Does LGC Biosearch Technologies synthesize minor groove binder (MGB) probes? | LGC Biosearch Technologies
Chemical and structural characterization of the interaction of bleomycin A<sub>2</sub> with d(CGCGAATTCGCG)<sub>2</sub>....
Heterocyclic diamidine interactions at AT base pairs in the DNA minor groove: effects of heterocycle differences, DNA AT...
PACL case: ED attaches assets worth Rs 472 cr in Australia | Business Standard News
Drug-DNA Interaction Protocols | SpringerLink
Side-Population Cells | Semantic Scholar
Estimating the Concentration of DNA by Fluorometry Using Hoechst 33258
Estimating the Concentration of DNA by Fluorometry Using Hoechst 33258
Re^5: Using Look-ahead and Look-behind
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Development and comparison of a Primer-Probe Energy Transfer based assay and a 5 conjugated Minor Groove Binder assay for...
Distamycin - Wikipedia
One Organic Chemist One Day: HOECHST
QuantiFluor-P Fluorometer Method For DNA Quantitation Using Hoechst 33258
m w i -Cellstain- Hoechst 33258 solution
Dehydroepiandrosterone supplier - Small Molecule Inhibitors of Protein Arginine Methyltransferases
Saccharomyces cerevisiae RAD5 influences the excision repair of DNA minor groove adducts. - Department of Oncology
Drug-DNA Interactions: Structures and Spectra | Biochemistry (Chemical Biology) | Chemistry | Subjects | Wiley
Alliance Pharmaceutical Corp. Announces Dismissal of Arbitration Proceedings With Hoechst Marion Roussel, Inc. - Free Online...
Methods In Molecular Biology Volume 90 Drug-DNA Interaction Protocols - ΒΙΟ-Αναγνώσεις
Hoechst image
SPRINT==| Query Results
Concatenar variables en sql server 2005 - Hosting Blog
Effects of minor and major groove-binding drugs and intercalators on the DNA association of minor groove-binding proteins RecA...
α Helix-RNA Major Groove Recognition in an HIV-1 Rev Peptide-RRE RNA Complex | Science
Plasmodium vivax: Isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved...
Dimerization of xanthorrhizol using peroxidase enzyme extracted from broccoli (Brasicca oleacea L) and its influence to the...
Design and synthesis of DNA minor groove methylating compounds that target pancreatic 7-cells, NC DOCKS (North Carolina Digital...
Splenocyte-Conditioned Media Inhibit Breast Cancer MCF-7 Cell Growth,
Associated with Increased Th2/Th1 Cytokine Secretion...
Representative images and quantitative analysis of CAOV | Open-i
Paid In America: The Road To The Middle | HPPR
Staining
Hoechst is a bis-benzimidazole derivative compound that binds to the minor groove of DNA. Often used in fluorescence microscopy ...
Hoechst stain
Latt, SA; Stetten, G (January 1976). "Spectral studies on 33258 Hoechst and related bisbenzimidazole dyes useful for ...
Thermoplastic
Polybenzimidazole (PBI, short for Poly-[2,2'-(m-phenylen)-5,5'-bisbenzimidazole]) fiber is a synthetic fiber with a very high ...
Molecules | Free Full-Text | Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H+)-ATPase Inhibitors
We identified a bisbenzimidazole derivative (V) as an initial hit from a similarity search using four known V-ATPase inhibitors ... The bisbenzimidazole derivative (2e) is active against all cell lines tested. Remarkably, it demonstrated high cytotoxicity ... To the best of our knowledge the bisbenzimidazole pharmacophore has been identified as the first V-ATPase inhibitor in its ... I-IV). Based on the initial hit (V), we designed and synthesized a focused set of novel bisbenzimidazole analogs (2a-e). All ...
Molecules | Free Full-Text | Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes
The crystal of [(tbbH2)(ttcH2)2(ttcH3)(H2O)] (2) is composed of a protonated bis(benzimidazole), two ttcH2 anions, ttcH3 and ... Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes. Pavel Kopel 1,2,* , Dorota ... "Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes." Molecules 20, no. 6: 10360- ... Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes. Molecules 2015, 20, 10360- ...
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1999) Bis-benzimidazole anticancer agents: Targeting human tumor helicases. Anticancer Drug Des 14:19-36. ... Transcriptional Regulation of Topoisomerase IIα at Confluence and Pharmacological Modulation of Expression by bis-Benzimidazole ... Transcriptional Regulation of Topoisomerase IIα at Confluence and Pharmacological Modulation of Expression by bis-Benzimidazole ... Transcriptional Regulation of Topoisomerase IIα at Confluence and Pharmacological Modulation of Expression by bis-Benzimidazole ...
Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines<...
keywords = "Benzimidazoles, Bis-benzimidazole-dihydroquinoxalines, Bis-benzimidazoles, Multi-component reactions (MCRs), UDC", ... Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines. Molecular ... Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines. In: ... Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines. / Xu, ...
Bis-benzimidazole derivatives as hepatitis c virus inhibitors
The present invention relates to a group of inhibiting HCV bis-benzimidazole derivatives with suitable properties for one or ... SUBSTANCE: invention refers to organic chemistry, namely to bis-benzimidazole derivatives of formula I and their optional ... This invention relates to derivatives of bis-benzimidazole, which are inhibitors of hepatitis C virus (HCV), their synthesis ... EFFECT: there are prepared bis-benzimidazole derivatives possessing the inhibitory activity on hepatitis C virus. ...
Naphthalenediimide-Linked Bisbenzimidazole Derivatives
as Telomeric G‑Quadruplex-Stabilizing Ligands with Improved
Anticancer...
Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G‑Quadruplex-Stabilizing Ligands with Improved Anticancer ... Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G‑Quadruplex-Stabilizing Ligands with Improved Anticancer ... Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G‑Quadruplex-Stabilizing Ligands with Improved Anticancer ... Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G‑Quadruplex-Stabilizing Ligands with Improved Anticancer ...
A Geometrically Constraining Bis(benzimidazole) Ligand and Its Nearly Tetrahedral Complexes with Fe(II) and Mn(II)
ChemIDplus - 23491-44-3 - INAAIJLSXJJHOZ-UHFFFAOYSA-N - Bisbenzimidazole - Similar structures search, synonyms, formulas,...
Stem cells and nervous tissue repair: from in vitro to in vivo
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21.
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
Structural assembly from 1D to 3D motivated by the linear co-ligands, and the magnetic and photocatalytic properties of five...
Stem Cells, Nonproliferating Cells, and Their Kinetics in Normal and Neoplastic Tissues | SpringerLink
Staining - Wikipedia
CHIMIA International Journal for Chemistry: Ingenta Connect Table Of Contents
Patente US7955889 - Organic photosensitive cells grown on rough electrode with nano-scale ... - Google Patentes
DNA Purification | DNA Extraction Methods | Promega
Zeitschrift für Naturforschung C Volume 46 Issue 7-8 (1991)
Overcoming transporter-mediated multidrug resistance in cancer: failures and achievements of the last decades | SpringerLink
Bernadou J[au] - PubMed - NCBI
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Antibacterial Thiazoles | Methicillin Resistant Staphylococcus Aureus | Antimicrobial Resistance
Hoechst stain - Wikipedia
Anne Marinier
Plus it
Jennifer Frankovich | Stanford Medicine Profiles
Protocols and Video Articles Authored by Vojtech Adam
Hoechst3
- Latt, S. A. and Stetten, G. (1976), Spectral studies on 33258 Hoechst and related bisbenzimidazole dyes useful for fluorescent detection of deoxyribonucleic acid synthesis. (springer.com)
- The five base pair protection patterns for Hoechst may result from a central three base pair recognition site bound by two bisbenzimidazole NHs forming a bridge on the floor of the minor groove between adjacent adenine N3 and thymine O2 atoms on opposite helix strands. (caltech.edu)
- Like bisbenzimidazole compound Hoechst 33258, these molecules also demonstrate AT-specific DNA binding. (iisc.ernet.in)
Ligands1
- In the present study, we have designed and synthesized three C 2 -symmetric bisubstituted bisbenzimidazole naphthalenediimide (NDI) ligands, ALI-C 3 , BBZ-ARO , and BBZ-AROCH 2 , which stabilize human telomeric G-quadruplex DNA with high affinity. (figshare.com)
Inhibitor1
- To the best of our knowledge the bisbenzimidazole pharmacophore has been identified as the first V-ATPase inhibitor in its class. (mdpi.com)
Synthesis2
- Agh-Atabay NM, Dulger B, Gucin F (2003) Synthesis and investigation of antimicrobial activity of some bisbenzimidazole-derived chelating agents. (springer.com)
- The synthesis and evaluation of the novel head-to-head bisbenzimidazole compound 2,2-bis[4'-(3 " -dimethylamino- 1 " -propyloxy)phenyl]-5,5-bi-1H-benzimidazole is described. (icr.ac.uk)
Search1
- We identified a bisbenzimidazole derivative ( V ) as an initial hit from a similarity search using four known V-ATPase inhibitors ( I - IV ). (mdpi.com)