Bis trimethylammonium compounds. Medical search

Organic salts or esters of methanesulfonic acid.

Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.

An antineoplastic agent with alkylating properties. It also acts as a mutagen by damaging DNA and is used experimentally for that effect.

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.

A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.

Chemical agents that react with SH groups. This is a chemically diverse group that is used for a variety of purposes. Among these are enzyme inhibition, enzyme reactivation or protection, and labelling.

Cetyltrimethylammonium compounds that have cationic detergent, antiseptic, and disinfectant activities. They are used in pharmaceuticals, foods, and cosmetics as preservatives; on skin, mucous membranes, etc., as antiseptics or cleansers, and also as emulsifiers. These compounds are toxic when used orally due to neuromuscular blockade.

Fatty acids which are unsaturated in only one position.

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.

The rate dynamics in chemical or physical systems.

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.

The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

Endogenous substances produced through the activity of intact cells of glands, tissues, or organs.

Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).

An aquatic genus of the family, Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.

The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Inorganic or organic compounds that contain sulfur as an integral part of the molecule.

Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.

Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

Compounds containing the -SH radical.

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.

A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.

Inorganic compounds that contain nitrogen as an integral part of the molecule.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

Organic compounds which contain selenium as an integral part of the molecule.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.

A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.

INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.

Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.

The process of finding chemicals for potential therapeutic use.

Compounds consisting of two or more fused ring structures.

A potent mast cell degranulator. It is involved in histamine release.

Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.

Compounds consisting of benzene rings linked to each other in either ortho, meta or para positions. Permitted are any substitutions, but ring fusion to any of the benzene rings is not allowed.

A cell line derived from cultured tumor cells.

Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.

A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).

The characteristic three-dimensional shape of a molecule.

Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)

A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.

Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Inorganic compounds that contain selenium as an integral part of the molecule.

The outer layer of the woody parts of plants.

Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.

Substances that reduce the growth or reproduction of BACTERIA.

A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

Organometallic compounds which contain tin and three alkyl groups.

Established cell cultures that have the potential to propagate indefinitely.

The above-ground plant without the roots.

A group of phenyl benzopyrans named for having structures like FLAVONES.

Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.

Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.

Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.

A class of compounds composed of repeating 5-carbon units of HEMITERPENES.

Cyclic hydrocarbons that contain multiple rings and share one or more atoms.

Virus diseases caused by the ADENOVIRIDAE.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.

Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.

A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.

The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.

Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

Compounds that contain a BENZENE ring fused to a furan ring.

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).

Inorganic compounds that contain gold as an integral part of the molecule.

A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)

Inorganic or organic compounds that contain divalent iron.

Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.

Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Elements of limited time intervals, contributing to particular results or situations.

Inorganic compounds that contain ruthenium as an integral part of the molecule.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.

A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.

A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Inorganic or organic compounds that contain boron as an integral part of the molecule.

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

Compounds containing the PhCH= radical.

Inorganic compounds that contain vanadium as an integral part of the molecule.

Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.

Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.

A genus of ascomycetous yeast in the family Saccharomycetaceae, order SACCHAROMYCETALES. Debaryomyces hansenni is a salt-tolerant marine species.

Sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.

Inorganic or organic compounds containing trivalent iron.

Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.

Triethylcholine compared with other substances affecting neuromuscular transmission. (1/18)

Triethylcholine (triethyl-2-hydroxyethyl ammonium) has been compared, in its actions on neuromuscular transmission, with the motor end-plate blocking drugs tubocurarine and decamethonium, with the anticholinesterase neostigmine, and with the closely related drug tetraethylammonium. The experiments were carried out on conscious rabbits and mice, on the tibialis anterior muscle of cats under chloralose anaesthesia and on the isolated phrenic nerve-diaphragm preparation of the rat. Anticholinesterase activity was determined manometrically using the Warburg apparatus. Triethylcholine possessed a slight curare-like action, but this effect was shown to be too weak and transient to contribute to the slowly developing and long-lasting transmission failure which occurs selectively in frequently excited nervemuscle preparations and in exercised conscious animals. It was confirmed that the site of the blocking action of triethylcholine was pre-junctional. Triethylcholine often produced a slight potentiation of the contractions before blocking them. This effect was not due to a depolarizing or an anticholinesterase action, and it was concluded that the slight initial facilitating action of triethylcholine on neuromuscular transmission was due to an increase in the quantity of acetylcholine released by the nerve impulse. Tetraethylammonium was much more powerful than triethylcholine in this respect. The pre-junctional transmission failure produced by triethylcholine could not be explained simply on the basis that an initial excessive release led to exhaustion of transmitter. (+info)

Effect of beta-diethylaminoethyl 3,3-diphenylpropylacetate on the action of suxamethonium and other neuromuscular blocking drugs. (2/18)

On the frog rectus abdominis muscle and on sciatic nerve-tibialis anterior muscle preparations, beta-diethylaminoethyl 3,3-diphenylpropylacetate (SKF 525A) antagonized the actions of acetylcholine and potassium chloride as well as having an antiveratrine action. The blocking action at the skeletal neuromuscular junction of suxamethonium and its disulphonium analogue, decamethonium, tubocurarine and gallamine was enhanced by SKF 525A in the rabbit and in the isolated rat phrenic nerve-diaphragm preparation. The activity of suxamethonium and decamethonium in the cat was reduced. On the rat phrenic nerve-diaphragm preparation, pretreatment with SKF 525A abolished both the mutual antagonism between suxamethonium and tubocurarine and the antagonizing effect of tetraethylammonium against suxamethonium. Theantagonism between tetraethylammonium and tubocurarine was unimpaired. (+info)

Stimulus frequency and neuromuscular block. (3/18)

Muscle twitches of the rat isolated diaphragm and frog sartorius preparations were recorded. It was confirmed that, in the presence of tubocurarine, the degree of neuromuscular block was greater the higher the frequency of stimulation. The results suggest that the quantity of acetylcholine released by each nerve impulse was reduced by increasing the rate of stimulation so that, in a tubocurarine solution, muscle fibres which were only just being fired at a slow rate of stimulation failed to fire at a faster rate. (+info)

Interaction of competitive antagonists: the anti-curare action of hexamethonium and other antagonists at the skeletal neuromuscular junction. (4/18)

1. In the rat isolated diaphragm preparation hexamethonium and other low potency competitive antagonists of acetylcholine (ACh), including gallamine and hyoscine butylbromide, reverse block by the potent antagonists tubocurarine, pancuronium and alcuronium. 2. In the presence of tubocurarine, hexamethonium increases the amplitude of the end-plate potential without increasing the quantal content. It enhances the response to ACh applied iontophoretically to the end-plate but does not enhance the response to ACh applied in the bath. 3. The anti-curare effect of hexamethonium is abolished in the diaphragm of the rat, guinea-pig and mouse by inhibitors of acetylcholinesterase. The effect is not observed in the indirectly stimulated toad sartorius muscle. 4. The effect is explained if tubocurarine does not dissociate appreciably in the time taken for ACh to achieve high occupancy of receptors, so that a fraction of receptors is completely excluded from occupation by ACh. Equilibration with hexamethonium reduces the fraction excluded by tubocurarine and the transmitter now competes with hexamethonium for more receptors and produces a larger response. 5. On the basis of this explanation the half-time for dissociation of tubocurarine must be about 1 millisecond. It follows that tubocurarine does not act competitively with ACh at synapses when transmitter action is sufficiently brief, and that its binding to the receptor is probably diffusion-limited. (+info)

RNA extraction from various recalcitrant plant tissues with a cethyltrimethylammonium bromide-containing buffer followed by an acid guanidium thiocyanate-phenol-chloroform treatment. (5/18)

High-quality total RNA was extracted using a cethyltrimethylammonium bromide-containing buffer followed by an acid guanidium thiocyanate-phenol-chloroform treatment from recalcitrant plant tissues such as tree leaves (pine, Norway spruce, ginkgo, Japanese cedar, rose), flowers (rose, Lotus japonicus) and storage tissues (seeds of Lotus japonicus and rice, sweet potato tuber, banana fruit). This protocol greatly reduced the time required for RNA extraction. (+info)

Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase. (6/18)

(+info)

Ionic control of the size of the vesicle matrix of beige mouse mast cells. (7/18)

Isolated matrices of the giant secretory vesicles of mast cells of the beige mouse were reliably produced by the osmotic lysis of isolated vesicles. These matrices maintained their form, and their sizes were easily measured using Nomarski optics. The size of the matrix depended on the ionic composition of the bathing solution. The physiologically relevant ions, histamine and serotonin, contracted the matrix. Multivalent cations condensed the matrix relative to univalents. Ag+, acid pH (below 5), and basic pH (above 9) expanded the matrix. In the presence of 10 mM histamine, lowering the pH from 9 to 5 contracted the matrix more than can be attributed to the pH-dependent matrix contraction in zero histamine. The nontitratable organic cation, dimethonium, contracts the matrix with little effect of pH in the range of 5-9. These results suggest that histamine acts as a matrix contractor in the divalent form. The dose-response (contraction) relation for histamine was gradual from micromolar to 316 mM (millimolar) histamine. Experiments with mixtures of histamine and sodium show antagonistic effects on the matrix but are inconsistent with either a model where ions compete for identical sites or a parallel model where ions interact with separate independent sites. In vigorous histamine washoff experiments, the half time for vesicle expansion in 10(-4) M pH buffer was approximately 4 s; in isotonic NaCl solution, it was 0.5 s. When 1 M histamine was presented to closely apposed matrices, fusion resulted. The matrix material returned to its initial shape after being mechanically deformed with a glass probe. These results suggest that the matrix size is controlled by its ion exchange properties. The matrix expansion can quantitatively account for the vesicular size increase observed upon exocytosis (as a postfusional event) and the osmotic nonideality of intact vesicles. The mechanical expansion is probably significant in the widening of the exocytotic pore and the dispersal of the vesicular contents. (+info)

Composition-insensitive highly viscous wormlike micellar solutions formed in anionic and cationic surfactant systems. (8/18)

We investigated phase behavior and rheological properties of aqueous micellar phase formed in water/cocoyl glutamate neutralized with triethanol amine (CGT-n)/hexadecyl trimethylammonium salt (CTAB or CTAC) systems, where n is a degree of neutralization. Micellar phase appears in wide composition range with respect to the surfactant mixing fraction in ternary phase diagrams at 25 degrees C. At high mixing fraction of cationic surfactant in the water/CGT-n/CTAB systems, one can observe a highly viscous micellar phase in which worm-like micelles are expected to form. Contrary to conventional systems in which worm-like micelles are formed, the zero-shear viscosity of the micellar solution in the water/CGT-n/CTAB system with n=1.2 increases with the addition of cationic cosurfactant and once decreases after a maximum, then increases again and decreases after the second maximum. At n=1.5 and 2, highly viscous solution is observed in the relatively wide range of surfactant mixing fraction instead of two maxima of the viscosity curve observed at n=1.2. In the case of CTAC instead of CTAB we can observe narrow composition range for the maximum viscosity. Frequency sweep measurements were performed on the highly viscous samples in the water/CGT-1.5/CTAB system. Typical viscoelastic behavior of worm-like micellar solutions is observed; i.e. the curves of storage (G') and loss (G") moduli make a crossover and the data points of G' and G" can be fitted to the Maxwell model. Relaxation time against the mixing fraction of two surfactants behaves similarly to the zero-shear viscosity change, whereas the plateau modulus continuously increases in the plateau region for the zero-shear viscosity curve. (+info)

Gastroenteritis can be classified into different types based on the cause:

Viral gastroenteritis - This is the most common type of gastroenteritis and is caused by norovirus or rotavirus.

Bacterial gastroenteritis - This type is caused by bacteria such as salmonella, E. coli, or campylobacter.

Parasitic gastroenteritis - This is caused by parasites such as giardia or cryptosporidium.

Foodborne gastroenteritis - This type is caused by consuming contaminated food or water.

Gastroenteritis can be treated with antibiotics for bacterial infections, anti-diarrheal medications, and hydration therapy to prevent dehydration. In severe cases, hospitalization may be necessary.

Prevention measures include proper hand washing, avoiding close contact with people who are sick, and avoiding contaminated food and water. Vaccines are also available for some types of gastroenteritis such as rotavirus.

Types of Adenoviridae Infections:

1. Respiratory adenovirus infection (bronchiolitis, pneumonia)
2. Gastroenteric adenovirus infection (gastroenteritis)
3. Eye adenovirus infection (conjunctivitis)
4. Skin adenovirus infection (keratoconjunctivitis)
5. Intestinal adenovirus infection (diarrhea, vomiting)
6. Adenovirus-associated hemorrhagic cystitis
7. Adenovirus-associated hypertrophic cardiomyopathy
8. Adenovirus-associated myocarditis

Symptoms of Adenoviridae Infections:

1. Respiratory symptoms (cough, fever, difficulty breathing)
2. Gastrointestinal symptoms (diarrhea, vomiting, abdominal pain)
3. Eye symptoms (redness, discharge, sensitivity to light)
4. Skin symptoms (rash, blisters, skin erosion)
5. Intestinal symptoms (abdominal cramps, fever, chills)
6. Cardiovascular symptoms (hypertension, tachycardia, myocarditis)

Diagnosis of Adenoviridae Infections:

1. Physical examination and medical history
2. Laboratory tests (rapid antigen detection, PCR, electron microscopy)
3. Imaging studies (chest X-ray, CT scan, MRI)
4. Biopsy (tissue or organ biopsy)

Treatment of Adenoviridae Infections:

1. Supportive care (fluids, oxygen therapy, pain management)
2. Antiviral medications (ribavirin, cidofovir)
3. Immune modulators (immunoglobulins, corticosteroids)
4. Surgical intervention (in severe cases of adenovirus-associated disease)

Prevention of Adenoviridae Infections:

1. Good hygiene practices (handwashing, surface cleaning)
2. Avoiding close contact with individuals who are infected
3. Properly storing and preparing food
4. Avoiding sharing of personal items (utensils, drinking glasses, towels)
5. Immunization (vaccination against adenovirus)

Incubation Period:
The incubation period for adenoviruses is typically between 3-7 days, but it can range from 1-2 weeks in some cases.

Contagious Period:
Adenoviruses are highly contagious and can be transmitted before symptoms appear and during the entire course of illness. The virus can be shed for several weeks after infection.

Risk Factors:
Individuals with weakened immune systems (children, elderly, those with chronic illnesses) are at a higher risk of developing severe adenovirus infections. Additionally, those who live in crowded or unsanitary conditions and those who engage in behaviors that compromise their immune system (smoking, excessive alcohol consumption) are also at a higher risk.

Complications:
Adenovirus infections can lead to a variety of complications, including pneumonia, meningitis, encephalitis, and other respiratory, gastrointestinal, and eye infections. In severe cases, adenovirus infections can be fatal.

Recovery Time:
The recovery time for adenovirus infections varies depending on the severity of the infection and the individual's overall health. Mild cases of adenovirus may resolve within a few days to a week, while more severe cases may take several weeks to recover from. In some cases, hospitalization may be necessary for individuals with severe infections or those who experience complications.

Contraception:
There is no specific contraceptive measure that can prevent adenovirus infections. However, practicing good hygiene, such as frequent handwashing and avoiding close contact with people who are sick, can help reduce the risk of transmission.

Pregnancy:
Adenovirus infections during pregnancy are rare but can be severe. Pregnant women who develop adenovirus infections may experience complications such as preterm labor and low birth weight. It is essential for pregnant women to seek medical attention immediately if they suspect they have an adenovirus infection.

Diagnosis:
Adenovirus infections can be diagnosed through a variety of tests, including polymerase chain reaction (PCR), electron microscopy, and culture. A healthcare provider will typically perform a physical examination and take a medical history to determine the likelihood of an adenovirus infection.

Treatment:
There is no specific treatment for adenovirus infections, but symptoms can be managed with supportive care such as hydration, rest, and over-the-counter pain relievers. Antiviral medications may be prescribed in severe cases or for individuals with compromised immune systems.

Prevention:
Preventing the spread of adenovirus is essential, especially in high-risk populations such as young children and those with weakened immune systems. Practicing good hygiene, such as frequent handwashing and avoiding close contact with people who are sick, can help reduce the risk of transmission. Vaccines are also available for some types of adenovirus.

Prognosis:
The prognosis for adenovirus infections is generally good, especially for mild cases. However, severe cases can lead to complications such as pneumonia, meningitis, and encephalitis, which can be life-threatening. In some cases, long-term health problems may persist after recovery from an adenovirus infection.

Complications:
Adenovirus infections can lead to various complications, including:

1. Pneumonia: Adenovirus can cause pneumonia, which is an inflammation of the lungs that can lead to fever, chest pain, and difficulty breathing.
2. Meningitis: Adenovirus can cause meningitis, which is an inflammation of the membranes surrounding the brain and spinal cord. Symptoms include headache, stiff neck, and sensitivity to light.
3. Encephalitis: Adenovirus can cause encephalitis, which is an inflammation of the brain that can lead to confusion, seizures, and coma.
4. Gastrointestinal symptoms: Adenovirus can cause gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain.
5. Long-term health problems: In some cases, adenovirus infections can lead to long-term health problems such as asthma, allergies, and autoimmune disorders.

... methacholine compounds MeSH D02.675.276.534.500 - methacholine chloride MeSH D02.675.276.558 - bis-trimethylammonium compounds ... bis-trimethylammonium compounds MeSH D02.092.877.250.372 - decamethonium compounds MeSH D02.092.877.250.592 - hexamethonium ... trimethyl ammonium compounds MeSH D02.092.877.883.077 - betaine MeSH D02.092.877.883.088 - bethanechol compounds MeSH D02.092. ... trialkyltin compounds MeSH D02.691.850.900.910 - triethyltin compounds MeSH D02.691.850.900.950 - trimethyltin compounds MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

This compound was able to compete with carnitine in binding to CRAT, but was unable to induce a reaction. The emergence of ... doi:10.1146/annurev.bi.57.070188.001401. PMID 3052273. "Entrez Gene: CRAT carnitine acetyltransferase". McGarry JD, Brown NF ( ... The literature suggests that the trimethylammonium group on carnitine may be a crucial factor in CRAT catalysis. This group ... This has been proven to be the case through the synthesis of a carnitine analog lacking its trimethylammonium group. ...

https://en.wikipedia.org/wiki/Carnitine_O-acetyltransferase

4N+ or abbreviated Bu4N+ trimethyl ammonium compounds, (CH3)3RN+ didecyldimethylammonium, (C10H21)2(CH3)2N+ ... bis(triphenylphosphine)iminium, ((C6H5)3P)2N+ quaternary ammonium cations having one triple-bonded substitution and one single- ... Compounds of an onium cation and some other anion are known as onium compounds or onium salts. Onium ions and onium compounds ... Cations, Queen Mary University of London) Ions and Radicals, Queen Mary University of London Onium compounds at the US National ...

https://en.wikipedia.org/wiki/Onium_ion

"Molybdenum and Molybdenum Compounds" in Ullmann's Encyclopedia of Chemical Technology 2005; Wiley-VCH, Weinheim. doi:10.1002/ ... S. Ghammami (2003). "The crystal and molecular structure of bis(tetramethylammonium) hexamolybdate(VI)". Crystal Research and ... 26 in trimethylammonium salt. The naming of molybdates generally follows the convention of a prefix to show the number of Mo ... In chemistry a molybdate is a compound containing an oxoanion with molybdenum in its highest oxidation state of 6. Molybdenum ...

https://en.wikipedia.org/wiki/Molybdate

The trimethyl ammonium group of Ach binds to the aromatic residue of tryptophan (Trp). The indole site provides a much more ... S-Adenosyl methionine (SAM) can act as a catalyst for the transfer of methyl group from the sulfonium compound to nucleophile. ... Complexes of Bis(N-heterocyclic carbene) Ligands Containing [Ni2(μ-OH)] Cores as Highly Efficient Catalysts for the Coupling of ... These interactions are commonly referred to as sandwich compounds. Specific research Due to reasons explained earlier in the ...

https://en.wikipedia.org/wiki/Pi-interaction

The hydrogen bond is responsible for many of the physical and chemical properties of compounds of N, O, and F that seem unusual ... Moore and Winmill used the hydrogen bond to account for the fact that trimethylammonium hydroxide is a weaker base than ... 8-bis(dimethylamino)naphthalene) and its derivatives also have symmetric hydrogen bonds ([N···H···N]+), although in the case of ... Lipinski CA (December 2004). "Lead- and drug-like compounds: the rule-of-five revolution". Drug Discovery Today: Technologies. ...

https://en.wikipedia.org/wiki/Hydrogen_bond

Methonium Compounds. Bis-Trimethylammonium Compounds. D03 - Heterocyclic Compounds. Kinetins. Kinetin. D06 - Hormones, Hormone ... Ammonium Compounds. Quaternary Ammonium Compounds. D02 - Organic Chemicals. 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine. 1-(5 ...

https://decs.bvs.br/I/rep_i2006.htm

https://decs.bvsalud.org/I/rep_i2006.htm

About Dodecyl-bis(2-hydroxyethyl)-methylazanium,chloride: Dodecyl-bis(2-hydroxyethyl)-methylazanium,chloride has the ... Stearyl trimethylammonium chloride Stearyl trimethyl ammonium chlorineide has the following characteristics: r… ... Compound Formula RO-(CH2CH2O)n-CH2COOH ... Dodecyl-bis(2-hydroxyethyl)-methylazanium-chloride. It is ... Stearyl trimethyl ammonium chloride. Cationic surfactants exhibit excellent emulsification. It can be used in conjunction with ...

https://www.iberocruceros.com/surfactant/IAEC-13nH-Isomeric-alcohol-ether-carboxylate-86-90.html

N(4)-bis(aminopropyl)spermidine(1+). 0. N(4)-bis(aminopropyl)spermidine(5+). 0. ... 4-(trimethylammonium)benzenediazonium. 0. 4-DAMP(1+) +. 12. 4-fluorobenzenaminium. 0. 4-hydroxy-N,N,N-trimethyltryptamine(1+). ... quaternary nitrogen compound +. 845. rocuronium +. 10. sphingoid-1-phosphocholine(1+) +. 0. sphingomyelin d18:1(1+). 0. ...

https://rgd.mcw.edu/rgdweb/ontology/annot.html?acc_id=CHEBI:35267

The new bis(pyrazolo[1,5-a]pyrimidines) were prepared in 80-90 % yields by reacting the respective bis(enaminones) and 4-(4- ... In addition, both compounds were also able to reduce the levels of some pro-inflammatory cytokines, such as IL-8, IL-6, and IL- ... 2-di-O-octadecenyl-3-trimethylammonium propane chloride (DOTMA), 1,2-distearoyl-3-trimethylammonium-propane chloride (DSTAP) ... Synthesis of New Bis(pyrazolo[1,5-a]pyrimidines) Linked to Different Spacers as Potential MurB Inhibitors. ...

https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:Propano

About Bismuth Nanoparticles Nano Bi Powder:Bismuth nanoparticles are a kind of metal nanoparticles with colors from dark […] ... Compound Formula. W. Molecular Weight. 183.85. Appearance. Black Powder. Melting Point. 3410 ℃. ... Previous: Stearyl trimethyl ammonium chloride. Next: TROX-300 Series Molecular Sieve. Related Posts. ...

https://www.nanouniverse-library.jp/tungsten-nanoparticles-nano-w-powder-cas-7440-33-7.html

Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, et al.; CRyPTIC Consortium and the 100,000 Genomes ... We extracted DNA from cultured isolates with the manual CTAB (cetyl trimethylammonium bromide) method and sequenced the whole ... Intensified incarceration at international borders may compound population-wide TB risk. However, few studies have investigated ...

https://wwwnc.cdc.gov/eid/article/27/3/20-3839_article

... compounds, in particular anions. Fast depuration may happen due to rapid metabolism or conjugation of charged compounds, and ... C18 TMAC.TMAC is an alkyl trimethyl ammonium chloride type of cationic surfactant, it is a mono-constituent with majorly C18 ... With regard to the kinetics, the transformation showed a slight bi-phasic pattern, therefore the Single First Order Model ( ... other quaternary ammonium compound benzyl-C12-16-alkyldimethyl ammonium chloride (C12-16-BKC/ADBAC) in a fish bioconcentration ...

https://echa.europa.eu/registration-dossier/-/registered-dossier/10127/5/4/3

The compound (I) crystallizes as a racemate in the centrosymmetric space group and the compound (II) crystallizes as a non- ... trimethyl ammonium chloride (MAPTAC), was grafted onto the MPTMS-TMSPMA gel. The Au NPs were assembled onto the thiol groups ... the matching bis-verdazyl radicals should be easily generated. As a result, 3,3- (1,4-phenylene) perchlorates are possible ... These types of compounds are in high demand by pharmaceutical, cosmetic, textile and food industries, leading to the search for ...

https://www.preprints.org/subject/browse/chemistry_and_materials_science/analytical_chemistry_50

Fatty acids are an important raw material for the synthesis of organic amine compounds. It is not only related to the ... such as monoalkyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, and benzyl ammonium chloride. Moreover, due ... N,N-Bis-(3-Aminopropyl)-Tallowalkylamines * N-Tallowalkyl Tripropylenetetramines * N-Oleyl Tripropylenetetramines ... production of tertiary amine fatty primary amines by nitrile method but also can form many compounds with special amino groups ...

http://www.blamine.com/products/amidoamines/

... polycation compound through electrostatic force action and hydrogen bond effect, achieving the packing to compounds. The novel ... methylene-bis-2-hydroxybenzaldehyde, then 5,5-methylene-bis-2-hydroxybenzaldehyde, DOPO (9,10-dihydro-9-oxa-10-phospha ... polyphosphoric acid and dodecyl trimethyl ammonium chloride are dissolved in phosphorus oxychloride, and 6-chlorine-8-methyl-9 ... and the target compound TPENNO2 is successfully used for the fluorescence imaging of a sulfhydryl compound in cells. The target ...

https://eureka.patsnap.com/list-patents-the-synthesis-steps-are-simple

Phosphorous acid, mixed 2,4-bis(1-methyl-1-phenylethyl)phenyl and isodecyl and 2-(1-methyl-1-phenylethyl)phenyl and 4-(1-methyl ... Benzene-1,2,4,5-tetracarboxylic acid, compound with 4,5-dihydro-2-phenyl-1H-imidazole (1:2) ... 3-methacrylamidopropyl)trimethylammonium chloride * (4R)-2-oxo-1,3-oxazolidine-4-carboxylic acid ...

https://watchdog.ecomole.com/en/changes/340/

Methacholine Compounds [D02.675.276.534] * Bis-Trimethylammonium Compounds [D02.675.276.558] * Decamethonium Compounds [D02.675 ... Bis-Trimethylammonium Compounds [D02.092.877.250] * Decamethonium Compounds [D02.092.877.250.372] * Hexamethonium Compounds [ ... Bis-Trimethyl-Ammonium Compounds Methonium Compounds Registry Number. 0. Public MeSH Note. 2006; see METHONIUM COMPOUNDS 1963- ... Bis-Trimethylammonium Compounds Preferred Concept UI. M0013593. Registry Number. 0. Scope Note. Compounds containing ...

https://meshb-prev.nlm.nih.gov/record/ui?ui=D008725

https://meshb.nlm.nih.gov/record/ui?ui=D008725

... disulfide N0000166634 Bis(Chloromethyl) Ether N0000166491 Bis-Trimethylammonium Compounds N0000179054 bisabolol N0000005898 ... Combination N0000166501 Trimethyl Ammonium Compounds N0000166555 Trimethylsilyl Compounds N0000166785 Trimethyltin Compounds ... Compounds N0000007682 Organomercury Compounds N0000007683 Organometallic Compounds N0000007684 Organophosphorus Compounds ... Compounds N0000007804 Organoselenium Compounds N0000008206 Organosilicon Compounds N0000008079 Organotechnetium Compounds ...

https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202012-06-04.txt

Methonium Compounds [P] MH NEW = Bis-Trimethylammonium Compounds MH OLD = Mice # [P] MH NEW = Mice MH OLD = Microspora [P] MH ... Ammonium Compounds [P] MH NEW = Quaternary Ammonium Compounds MH OLD = Anti-Allergic and Respiratory System Agents # [] MH NEW ...

https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/.bkup/replace2006.07-25-2005.txt

Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide Bis(Chloromethyl) Ether Bis-Trimethylammonium Compounds Bisacodyl ... Bridged Bicyclo Compounds Bridged Bicyclo Compounds, Heterocyclic Bridged-Ring Compounds Brief Psychiatric Rating Scale ... Benzyl Compounds Benzyl Viologen Benzylamine Oxidase Benzylamines Benzylammonium Compounds Benzylidene Compounds ... Benzalkonium Compounds Benzamides Benzamidines Benzazepines Benzbromarone Benzenaminium, 4,4-(3-oxo-1,5-pentanediyl)bis(N,N- ...

https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/mshd2017.txt

Elimination was bi-phasic, with half-lives of 0.75-1.6 h and 3.4-3.6 h for phases 1 and 2, respectively. The dermal application ... N-trimethyl ammonium chloride DTAC were investigated. The results showed that C12-En-C12 and C12-Bm-C12 had markedly lower ... extract-loaded transferosomes represent an advanced approach for enhancing skin permeation of bioactive compounds. The ... Here, we develop a delivery system based on dual light and pH responsive vesicles having a cationic bis-quat gemini surfactant ...

https://pesquisa.bvsalud.org/brasil/?lang=pt&q=mh:Tensoativos

Microbiocidal activity of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride. Chi, Weilin, Qin, Caiqin, Zeng, Lintao, Li, ... Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (e)- and (z)-9-{[2,2-bis( ... Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis ... 1,2,4-Thiadiazole derivative antifungal compounds, compositions containing them, and preparation and use thereof ...

https://chemdb.niaid.nih.gov/memo/OI-LS-373.aspx

https://wwwnc.cdc.gov/eid/article/27/3/20-3839

Diclazuril-bis, DNC-d8 and nigericin were used as internal standards. The results of the full validation in accordance with the ... None of the compounds affected KISS-ir in the male hypothalamus. Our results suggest that the organization of hypothalamic KISS ... AB - A relatively quick and inexpensive modified cetyl trimethylammonium bromide method for extraction of DNA from leaf ... AB - p,p-DDE, or ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl), is the main metabolite of the pesticide DDT, or 1,1,1- ...

https://data.lhncbc.nlm.nih.gov/public/ii/information/MBR/Download/MetaMapped_Medline/2019/MEDLINE/pubmed19n0629.txt

Compound 19 was identified as a new lead for its selective D2 G-protein biased agonism with an EC50 in the subnanomolar range. ... Galaj, Ewa; Bi, Guo-Hua; Klein, Benjamin; Hempel, Briana; Shaik, Anver Basha; Gogarnoiu, Emma S; Friedman, Jacob; Lam, Jenny; ... trimethylammonium)ethyl]-methanethiosulfonate reactivity on the DAT E2C I159C. Microdialysis studies demonstrated that both R- ... Compound 19 was identified as a new lead for its selective D2 G-protein biased agonism with an EC50 in the subnanomolar range. ...

https://irp.nida.nih.gov/staff-members/amy-hauck-newman/

https://wwwnc-origin.cdc.gov/eid/article/27/3/20-3839

... birth weight birth-weight birthweights birth weights birth-weights birthwort birthworts Bis Bis BIs B-Is B-Is BIs BIS ... azocasein azocene azocine azocines azocoll azocompound azo compound azo-compound azocompounds azo compounds azo-compounds ... butynoic acid butynorate butynyl butynyls butynyltrimethylammonium butynyl trimethyl ammonium butynyl-trimethylammonium ... biimidazoles biinstitutional bi-institutional biionic bi-ionic biioquinol bi-ischiac bi-ischiadic biischial bi-ischial bi- ...

https://lexsrv3.nlm.nih.gov/LexSysGroup/Projects/gSpell/current/data/2006LexiconTerms.txt

Cationic Chloride Cations Synthesis Agents

16. Cationic vesicles consisting of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and phosphatidylcholines and their interaction with erythrocyte membrane. (nih.gov)
This paper presents a simple treatment of unbleached Norway spruce ( Picea abies ) process water from TMP (thermomechanical pulping) production using induced air flotation (IAF) and cationic surfactant, dodecyl trimethylammonium chloride (DoTAC) to refine the extractives and prepare the waters so that hemicellulose could be easily harvested at a later stage. (ncsu.edu)

TRUNNANO is a reliable supplier for Dodecyl-bis(2-hydroxyethyl)-methylazanium,chloride. (robocup2009.org)

Compounds containing polymethylene bis-trimethylammonium cations. (nih.gov)

18. Synthesis, structure and biological evaluation of bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(iii) triphenylphosphine. (nih.gov)
Fatty acids are an important raw material for the synthesis of organic amine compounds. (blamine.com)

Compounds with this moiety are alkylating agents that may damage DNA. (nih.gov)

Anatomy9

Organisms6

Diseases2

Chemicals and Drugs87

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes26

Disciplines and Occupations3

Technology, Industry, Agriculture2

Information Science2

Health Care1

Triethylcholine compared with other substances affecting neuromuscular transmission. (1/18)

Effect of beta-diethylaminoethyl 3,3-diphenylpropylacetate on the action of suxamethonium and other neuromuscular blocking drugs. (2/18)

Stimulus frequency and neuromuscular block. (3/18)

Interaction of competitive antagonists: the anti-curare action of hexamethonium and other antagonists at the skeletal neuromuscular junction. (4/18)

RNA extraction from various recalcitrant plant tissues with a cethyltrimethylammonium bromide-containing buffer followed by an acid guanidium thiocyanate-phenol-chloroform treatment. (5/18)

Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase. (6/18)

Ionic control of the size of the vesicle matrix of beige mouse mast cells. (7/18)

Composition-insensitive highly viscous wormlike micellar solutions formed in anionic and cationic surfactant systems. (8/18)

Mesylates

Quaternary Ammonium Compounds

Ethyl Methanesulfonate

Cysteine

Diphenylhexatriene

Sulfhydryl Reagents

Cetrimonium Compounds

Fatty Acids, Monounsaturated

Indicators and Reagents

Cations

Surface-Active Agents

Parasympathomimetics

Structure-Activity Relationship

Liposomes

Kinetics

Mutagenesis, Site-Directed

Amino Acid Substitution

Xenopus laevis

Ion Channel Gating

Protein Conformation

Protein Structure, Tertiary

Acetylcholine

Bodily Secretions

Oocytes

Xenopus

Binding Sites

Biological Transport

Membrane Potentials

Protein Binding

Cell Membrane

Molecular Sequence Data

Sodium

Mutation

Patch-Clamp Techniques

Amino Acid Sequence

Molecular Structure

Sulfur Compounds

Volatile Organic Compounds

Plant Extracts

Drug Evaluation, Preclinical

Magnetic Resonance Spectroscopy

Phenols

Heterocyclic Compounds

Inhibitory Concentration 50

Biphenyl Compounds

Sulfhydryl Compounds

Small Molecule Libraries

Organotin Compounds

Aniline Compounds

Spiro Compounds

Nitrogen Compounds

Chromatography, High Pressure Liquid

Stereoisomerism

Drug Design

Dose-Response Relationship, Drug

Nitroso Compounds

Organometallic Compounds

Organoselenium Compounds

Drug Screening Assays, Antitumor

Organophosphorus Compounds

Azo Compounds

Gas Chromatography-Mass Spectrometry

Epoxy Compounds

Gastroenteritis

High-Throughput Screening Assays

Drug Discovery

Polycyclic Compounds

p-Methoxy-N-methylphenethylamine

Hydrocarbons, Aromatic

Antineoplastic Agents

Enzyme Inhibitors

Mass Spectrometry

Benzyl Compounds

Organic Chemicals

Terphenyl Compounds

Cell Line, Tumor

Triterpenes

Furans

Oxidation-Reduction

Molecular Conformation