Bis chloromethyl ether. Medical search

An inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process.

An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.

A substance that is an irritant to the eyes and respiratory tract and may be carcinogenic.

Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.

A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

Compounds that contain two halogenated benzene rings linked via an OXYGEN atom. Many polybrominated diphenyl ethers are used as FLAME RETARDANTS.

Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.

Ethers that are linked to a benzene ring structure.

A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.

Macrocyclic polyethers with the repeating unit of (-CH2-CH2-O)n where n is greater than 2 and some oxygens may be replaced by nitrogen, sulfur or phosphorus. These compounds are useful for coordinating CATIONS. The nomenclature uses a prefix to indicate the size of the ring and a suffix for the number of heteroatoms.

Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.

Compounds that contain a 1-dimethylaminonaphthalene-5-sulfonyl group.

Chemical compounds derived from acids by the elimination of a molecule of water.

Compounds in which one or more of the three hydroxyl groups of glycerol are in ethereal linkage with a saturated or unsaturated aliphatic alcohol; one or two of the hydroxyl groups of glycerol may be esterified. These compounds have been found in various animal tissue.

Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.

A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.

Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)

A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.

An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided the next residue is not proline. It is inhibited by thiol-blocking reagents and occurs in mammalian tissues, microorganisms, and plants. (From Enzyme Nomenclature, 1992) EC 3.4.19.3.

Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.

An organic mercurial used as a sulfhydryl reagent.

The rate dynamics in chemical or physical systems.

A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.

A group of compounds that contain the general formula R-OCH3.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.

The sum of the weight of all the atoms in a molecule.

An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

A genus of microorganisms of the order SPIROCHAETALES, many of which are pathogenic and parasitic for man and animals.

Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.

Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.

A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.

An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.

The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

Physiologically inactive substances that can be converted to active enzymes.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.

Materials applied to fabrics, bedding, furniture, plastics, etc. to retard their burning; many may leach out and cause allergies or other harm.

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.

Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.

The process of cleaving a chemical compound by the addition of a molecule of water.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.

Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.

Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.

Compounds of the general formula R-O-R arranged in a ring or crown formation.

Peptides composed of between two and twelve amino acids.

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.

GLYCEROPHOSPHOLIPIDS in which one of the two acyl chains is attached to glycerol with an ether alkenyl linkage instead of an ester as with the other glycerophospholipids.

Established cell cultures that have the potential to propagate indefinitely.

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.

Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

BCME (Bis(chloromethyl) ether) is associated with small cell lung cancer in workers who have been exposed. Exposure can occur ... "Bis(chloromethyl)ether (BCME) (CASRN 542-88-1)". IRIS (Integrated Risk Information System). EPA. 31 October 2014. Retrieved 31 ...

https://en.wikipedia.org/wiki/Occupational_lung_disease

Bis(chloromethyl) ether HN3 (nitrogen mustard) Lewisite Selenium mustard Sesquimustard "FM 3-8". Chemical Reference Handbook. ...

https://en.wikipedia.org/wiki/O-Mustard

... bis(chloromethyl) ether, and 10% tetrachloromethane. A later formulation, Gelbkreuz 1, was a mixture of 40% ethyldichloroarsine ... 40% ethyldibromoarsine, and 20% of bis(chloromethyl) ether. In some cases nitrobenzene was used to mask the material's ...

https://en.wikipedia.org/wiki/Yellow_Cross_(chemical_warfare)

... the production of small amounts of highly carcinogenic bis(chloromethyl) ether is a disadvantage for industrial applications. ... The reaction is performed with care as, like most chloromethylation reactions, it produces highly carcinogenic bis(chloromethyl ... Deactivated substrates give better results under modified chloromethylation conditions using chloromethyl methyl ether (MOMCl) ... H2O Chloromethylation can also be effected using chloromethyl methyl ether: ArH + CH3OCH2Cl → ArCH2Cl + CH3OH This reaction is ...

https://en.wikipedia.org/wiki/Blanc_chloromethylation

... the highly carcinogenic side product bis(chloromethyl) ether is not generated. Merck Index, 11th Edition, 5936 NIOSH Pocket ... This is a preferred method to using chloromethyl methyl ether (MOMCl). Alternatively, MOMCl can be prepared as a solution in a ... minimizing contact with the carcinogenic chloromethyl methyl ether. Unlike the classical procedure, which uses formaldehyde and ... "Synthesis of Alpha-Halo Ethers from Symmetric Acetals and in situ Methoxymethylation of an Alcohol". Organic Syntheses. 84: 102 ...

https://en.wikipedia.org/wiki/Dimethoxymethane

... chloromethyl) ether is a disadvantage for industrial applications. Dimethylformamide and phosphorus oxychloride in the ... Deactivated substrates are suitable for this reaction, although the production of small amounts of highly carcinogenic bis( ... Formylation of benzene rings could be accomplished by Blanc chloromethylation and a further oxidation of the chloromethyl group ... Chloroform in the Reimer-Tiemann reaction dichloromethyl methyl ether in Rieche formylation. Formylation of 3-methylamino-1- ...

https://en.wikipedia.org/wiki/Formylation_reaction

Bis(chloromethyl)ether Chloromethyl methyl ether Chromium(VI) (Hexavalent chromium) compounds Ciclosporin Cyclophosphamide 1,2- ... N-Bis(2-chloroethyl)-2-naphthylamine) Chlorambucil Methyl-CCNU (1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; ...

https://en.wikipedia.org/wiki/List_of_IARC_Group_1_Agents_-_Carcinogenic_to_humans

... methyl ether (technical grade), and bis-(chloromethyl) ether, sulfur mustard, MOPP (vincristine-prednisone-nitrogen mustard- ...

https://en.wikipedia.org/wiki/Lung_cancer

The molecular formula C2H4Cl2O (molar mass: 114.96 g/mol, exact mass: 113.9639 u) may refer to: Bis(chloromethyl) ether ... Dichloromethyl methyl ether This set index page lists chemical structure articles associated with the same molecular formula. ...

https://en.wikipedia.org/wiki/C2H4Cl2O

Bis(chloromethyl) ether Blister agent Chlorine gas Half mustard Lewisite Nitrogen mustard Phosgene oxime Poison gas in World ... Examples are bis(2-chloroethyl)ether, the (2-haloethyl)amines (nitrogen mustards), and sulfur sesquimustard, which has two α- ... A mixture of 60% mustard gas (HD) and 40% T (bis[2-(2-chloroethylthio)ethyl] ether), a related vesicant with lower freezing ... Distilled sulfur mustard (bis(2-chloroethyl) sulfide); approximately 96% pure. The term "mustard gas" usually refers to this ...

https://en.wikipedia.org/wiki/Mustard_gas

C Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether CAS Nos. 542-88-1 and 107-30-2, Report on carcinogens, ... characterized as an ether connected to a chloromethyl group via an alkane chain. Chloromethyl methyl ether (CMME) is an ether ... chloromethyl) ether (BCME) (closely related to chemical weapon sulfur mustard) and benzyl chloromethyl ether (BOMCl). 2- ... Eleventh edition Bis(Chloromethyl) ether Safety Data Sheet, Division of Occupational Health and Safety, US National Institutes ...

https://en.wikipedia.org/wiki/Chloroalkyl_ether

... is considered as a potential carcinogen. Bis(chloromethyl) ether Sulfur mustard NIOSH Pocket Guide to ... Bis(chloroethyl) ether is an organic compound with the formula O(CH2CH2Cl)2. It is an ether with two 2-chloroethyl substituents ... Bis(chloroethyl) ether is less reactive than the corresponding sulfur mustard S(CH2CH2Cl)2. In the presence of base, it reacts ... When treated with strong base, it gives divinyl ether, an anesthetic: O(CH2CH2Cl)2 + 2 KOH → O(CH=CH2)2 + 2 KCl + 2 H2O The ...

https://en.wikipedia.org/wiki/Bis(chloroethyl)_ether

Monochloromethyl ether, Organic Syntheses I, 377 bis(Chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether CAS Nos ... Chloromethyl methyl ether (CMME) is a compound with formula CH3OCH2Cl. It is a chloroalkyl ether. It is used as an alkylating ... methanol and hydrogen chloride yields material contaminated with a significant amount of the dangerous bis(chloromethyl) ether ... Rapid Procedure for the Synthesis of Chloromethyl Methyl Ether and Other Chloro Alkyl Ethers 1". The Journal of Organic ...

https://en.wikipedia.org/wiki/Chloromethyl_methyl_ether

... was no exception to this with production in the U.S.A. ending in 1982. Bis(chloromethyl) ether has been ... It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. Bis(chloromethyl) ether ... Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. "#0128". ... Chloromethylation of benzene and alkylbenzenes with bis(chloromethyl)ether, 1,4-bis(chloromethoxy)butane, 1-chloro-4- ...

https://en.wikipedia.org/wiki/Bis(chloromethyl)_ether

N-Bis(2-chloroethyl)-2-naphthylamine) Bis(chloromethyl)ether Chloromethyl methyl ether 1,3-Butadiene 1,4-Butanediol ...

https://en.wikipedia.org/wiki/List_of_IARC_Group_1_carcinogens

... chloride Chloroacetic acid 2-chloroethanol Chloroethyl chloroformate Chloroform Chloromethyl ether Chloromethyl methyl ether ... heptane-2-carbonitrile Bis(chloromethyl) ketone Bitoscanate Boron trichloride Boron trifluoride Boron trifluoride compound with ... 3-bis(chloromethyl)- Oxydisulfoton Paraquat Paraquat methosulfate Parathion Parathion-methyl Paris green Pentaborane ... bis(1-methylethyl)amino)ethyl) O-ethyl ester Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester Phosphoric acid, ...

https://en.wikipedia.org/wiki/EPA_list_of_extremely_hazardous_substances

3-bis(chloromethyl)benzo[c] thiophene 2,2-dioxide (0.584 g, 2.2 mmol) in 50 mL of dry benzene was added 0.80 mL (2.8 mmol) of a ... 10)). Ether cleavage is difficult to accomplish with most hydride reagents. However, debenzylation of benzyl aryl ethers may be ... The most common solvents used are tetrahydrofuran and diethyl ether. Whatever solvent is used should be anhydrous and pure. ... In a related application, NaAlH2(OCH2CH2OCH3)2 (sodium bis(methoxyethoxy) aluminium dihydride, SMEAH or Red-Al) reacts with ...

https://en.wikipedia.org/wiki/Reductions_with_metal_alkoxyaluminium_hydrides

Bis(2-chloroethylthio) methane Bis(2-chloroethylthiomethyl) ether Bis(2-chloroethylthioethyl) ether (O Mustard; T) ... Chloromethyl chloroformate Dibenzoxazepine (CR) Ethyl iodoacetate Ortho-chlorobenzylidene malononitrile (Super tear gas; CS) ... Bis(2-chloroethyl)ethylamine (HN1) Bis(2-chloroethyl)methylamine (HN2) Tris(2-chloroethyl)amine (HN3) 1,2-Bis(2-chloroethylthio ... 4-Bis(2-chloroethylthio)-n-butane 1,5-Bis(2-chloroethylthio)-n-pentane 2-Chloroethylchloromethylsulfide Bis(2-chloroethyl) ...

https://en.wikipedia.org/wiki/List_of_chemical_warfare_agents

For example, enol ethers like trimethylsilyloxy-substituted olefins are often used because of the high yields obtained. Despite ... Denmark, S. E.; Edwards, J. P. (1991). "A Comparison of (Chloromethyl)- and (Iodomethyl)zinc Cyclopropanation Reagents". J. Org ... Cyclopropan-Bildung aus Olefinen mit Bis-halogenmethyl-zink". Chemische Berichte. 97 (8): 2146-2164. doi:10.1002/cber. ... The modification was proposed in 1968 as a way to turn cationically polymerizable olefins such as vinyl ethers into their ...

https://en.wikipedia.org/wiki/Simmons–Smith_reaction

Smith, A. P.; Lamba, J. J. S.; Fraser, C. L. (2004). "Efficient Synthesis of Halomethyl-2,2'-Bipyridines: 4,4'-Bis(chloromethyl ... As such it is commercially available as a solution in polar aprotic solvents such as THF and ether; however, for small scale ... Lithium amide Lithium bis(trimethylsilyl)amide (LiHMDS) Lithium tetramethylpiperidide (LiTMP) Evans pKa Table Hamell, Matthew; ...

https://en.wikipedia.org/wiki/Lithium_diisopropylamide

The Quelet reaction (also called the Blanc-Quelet reaction) is an organic coupling reaction in which a phenolic ether reacts ... R. Quelet (1932). "preparation d'un derive chloro-methyl du para-bromo-anisol (methoxy-2 bromo-2 α-chlorotoluene)". Compt. Rend ... Sugawasa, Shigehiko; Fuijsawa, Toshiro; Okada, Kozo (1952). "Synthesis of 2,2-Polymethylene-bis-(Py-tetrahydroisoquinoline) ... The Quelet reaction can produce dangerous halomethyl ethers, gaseous and liquid compounds that are toxic to humans, and ...

https://en.wikipedia.org/wiki/Quelet_reaction

Silyl ethers have the connectivity Si-O-C. They are typically prepared by the reaction of alcohols with silyl chlorides: (CH3) ... Commun., 2002, (4), 348-349 doi:10.1039/b109816k Mechanistic insight into copper-catalysed allylic substitutions with bis( ... chloromethyl)silane, trichloro(dichlorophenyl)silane, trichloroethylsilane, and phenyltrichlorosilane. Although proportionately ... are used in deprotection of silyl ethers: (CH3)3Si-O-R + F− + H2O → (CH3)3Si-F + H-O-R + OH− Organosilyl chlorides are ...

https://en.wikipedia.org/wiki/Organosilicon

2,3-Bis(acetylmercaptomethyl)quinoxaline. *Bis(chloroethyl) ether. *Bisbiguanide. *Bismuth(III) acetate ... Chloromethyl chloroformate. *Chlorophenol red. *(2-Chlorophenyl)thiourea. *3-Chloropropyl octyl sulfoxide. *Chloroxuron ...

https://en.wikipedia.org/wiki/Category:Organic_compound_stubs

Bis(chloromethyl) ether is highly irritating to the skin, eyes, nose, throat, and lungs and it is a carcinogen. Bis( ... chloromethyl) ether is only used in small amounts inside fully enclosed systems to make other chemicals. Use of this chemical ... chloromethyl) ether has been found at 2 of the 1,518 National Priorities List sites identified by the Environmental Protection ... What is bis(chloromethyl) ether?. Bis(chloromethyl) ether is a clear liquid with a strong unpleasant odor. It does not occur ...

https://wwwn.cdc.gov/TSP/ToxFAQs/ToxFAQsDetails.aspx?faqid=918&toxid=188

Bis(chloromethyl)ether. CAS No: 542-88-1. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references ... Bis(chloromethyl)ether. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ... 2005-110) - Bis(chloromethyl)ether ...

https://www.cdc.gov/niosh/docs/2005-110/nmed0026.html

Toxicological profile for bis(chloromethyl)ether. Atlanta, GA: U.S. Department of Health and Human Services, Public Health ...

https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=919&tid=188

Bis(chloromethyl) ether was no exception to this with production in the U.S.A. ending in 1982. Bis(chloromethyl) ether has been ... It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. Bis(chloromethyl) ether ... Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. "#0128". ... Chloromethylation of benzene and alkylbenzenes with bis(chloromethyl)ether, 1,4-bis(chloromethoxy)butane, 1-chloro-4- ...

https://en.wikipedia.org/wiki/Bis(chloromethyl)_ether

... bis-CME, Dichlorodimethyl ether, Dichloromethyl ether, Oxybis(chloromethane) Colorless liquid with a suffocating odor. ... bis-Chloromethyl ether. ... BCME, Chloromethyl ether, bis-CME, Dichlorodimethyl ether, ...

https://www.cdc.gov/niosh/npg/npgd0128.html

39 FR 23502, June 27, 1974. Redesignated at 40 FR 23072, May 28, 1975, and amended at 41 FR 35184, Aug. 20, 1976; 43 FR 49751, Oct. 24, 1978; 43 FR 51760, Oct. 24, 1978; 45 FR 35282, May 23, 1980; 47 FR 14696 and 14706, Apr. 6, 1982; 49 FR 18295, Apr. 30, 1984; 58 FR 35310, June 30, 1993; 61 FR 5507, Feb. 13, 1996; 61 FR 9227, March 7, 1996]. ...

https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1008

This page contains information on the chemical bis-Chloromethyl ether including: 34 synonyms/identifiers; U.S. Code of Federal ... BIS(CHLOROMETHYL) ETHER*Bis(chloromethyl) ether*Bis(Chloromethyl) Ether (Bcme) *Bis-(chloromethyl) ether*bis-Chloromethyl ether ... bis-Chloromethyl ether (EnvironmentalChemistry.com),/a,- This page contains information on the chemical bis-Chloromethyl ether ... Dichloromethyl ether*Dichloromethyl ether, symmetrical*Dimethyl-1,1-dichloroether*Ether, bis(chloromethyl) *Methane, oxybis( ...

https://environmentalchemistry.com/yogi/chemicals/cn/bis-Chloromethyl%A0ether.html

... chloromethyl)ether (TR) (Toxicity Review), The toxicity of nickel and its inorganic compounds, 4,4-methylene Dianiline, 1,4- ... Bis(chloromethyl)ether (TR) (Toxicity Review) by J.I. Delic, S. Fairhurst 1 edition - first published in 1990 ...

https://openlibrary.org/authors/OL912187A/S._Fairhurst

... bis-Chloromethyl ether*. 543-27-1.................................. i-Butyl chloroformate. 555-77-1 ... 163702-08-7............................ Methyl nonafluorobutyl ether (HFE 7100 component). The Second Priority List of AEGL ... 353-42-4................................. Boron triflouride compound with methyl ether (note: boron trifluoride CAS # is 7637- ...

https://www.epa.gov/aegl/chemical-priority-lists-acute-exposure-guideline-levels-aegls

... methyl chloromethyl ether; bis-chloromethyl ether; beta-Naphthylamine; benzidine or 4-Aminodiphenyl; and ... methyl chloromethyl ether; bis-chloromethyl ether; beta-Naphthylamine; benzidine or 4-Aminodiphenyl; and ... methyl chloromethyl ether; bis-chloromethyl ether; beta-Naphthylamine; benzidine or 4-Aminodiphenyl; and ...

https://www.osha.gov/laws-regs/federalregister/1996-03-07-0

Bis(Chloromethyl) Ether. 542-88-1. 100. Boron Trichloride. 10294-34-5 ...

https://apps.leg.wa.gov/WAc/default.aspx?cite=296-67-285

Bis(chloromethyl)ether 680319. Hexamethylphosphoramide 684935. N-Nitroso-N-methylurea 1120714. 1,3-Propane sultone ...

https://www.law.cornell.edu/cfr/text/40/appendix-Table_16_to_subpart_XXXX_of_part_63

Bis(2-ethylhexyl)phthalate (DEHP). 542881. Bis(chloromethyl)ether. 75252. Bromoform. 106990 ... R′ = R, H, or groups which, when removed, yield glycol ethers with the structure: R-(OCH2CH)n-OH. Polymers are excluded from ... 2 Includes mono- and di- ethers of ethylene glycol, diethylene glycol, and triethylene glycol R-(OCH2CH2)n-OR′ where ... NOTE: For all listings above which contain the word "compounds" and for glycol ethers, the following applies: Unless otherwise ...

https://www.law.cornell.edu/uscode/text/42/7412

4,4 Methylene bis (2 - chloroaniline). Methyl chloromethyl ether. 3,3-Dichlorobenzidine (and its salts) ...

https://apps.leg.wa.gov/WAC/default.aspx?cite=296-828&full=true

bis(chloromethyl) ether Mass :114.959 Formula : C2H4Cl2O iodoacetic acid Mass :185.94850 Formula : C2H3IO2 ... 2,5-bis(aziridin-1-yl)-1,4-benzoquinone Mass :190.19868 Formula : C10H10N2O2 ... 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone Mass :308.334 Formula : C14H20N4O4 ...

https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=22333

3.1.3. Bis chloromethyl ether (BCME). 3.1.4. Chromium and chromium compounds. 3.1.5. Coal tars and coal tar pitches; soot. 3.1. ...

http://www.ilo.org/public/english/standards/relm/ilc/ilc90/rep-v-2b.htm

BIS(CHLOROMETHYL)ETHER. 602. 542-88-1. 237. CARBOPHENOTHION. 602. 786-19-6. ...

https://www.atsdr.cdc.gov/spl/index.html

The formation of bis-chloromethyl ether from HCl and formaldehyde is well-known in the chemical literature. I just thought Id ... The reaction product is called bis-chloromethyl ether. Cl-CH2-O-CH2-Cl. This material is one of the most potent carcinogens ... that some bis-chloromethyl ether should be formed in vivo. Clearly, the extent of its formation depends on the other contents ... bis-chloromethyl ether. These people are running around sipping on carcinogenic precursors, and then they wonder why cancer ...

http://rense.com/general96/dangerfacingtrump.html

Bis(chloromethyl) ether. Lung. Chemical intermediate/by-product. Cadmium and cadmium compounds ...

https://link.springer.com/article/10.1007%2Fs12094-018-02016-4

CHLOROETHYL) ETHER. 2-AMINO-5-(S-NITRO-2-FURYL)-1,3,4-THIADIAZOLE 815 BIS-CHLOROMETHYL ETHER. ... METHYLENE BIS (4 CYCLOHEXYLISOCYANATE) ORTHO-TOLIDINE 4,4 - METHYLENE BIS(N,N-DIMETHYL) BENZENAMINE ORTHO-TOLUIDINE AND ITS ...

https://www.ihs.gov/IHM/index.cfm?module=dsp_ihm_circ_main&circ=ihm_circ_9402_apx_942e

... and bis(chloromethyl)ether. Some intelligent guessing based on structural analogies for the chemicals is made where little ... Ether/bis(chloromethyl) ; Benzidine/dichloro ; Benzidines ; Naphthylamines ; Ethylidenimines ; Propiolactone ; Aniline/ ...

https://cfpub.epa.gov/ols/catalog/advanced_brief_record.cfm?&FIELD1=AUTHOR&INPUT1=HOLT%20AND%20R.%20AND%20B.&TYPE1=ALL&LOGIC1=AND&COLL=&SORT_TYPE=MTIC&item_count=16

... ether: (Human Health Carcinogen - fish ingestion only), Indiana Department of Environmental Management. Bis(chloromethyl)ether ... Human Health Carcinogen Fact Sheet for Bis(chloromethyl) ether: (Human Health Carcinogen - fish ingestion only), Indiana ... Human Health Carcinogen Fact Sheet for Bis(chloromethyl) ...

https://19january2021snapshot.epa.gov/gliclearinghouse/human-health-carcinogen-fact-sheet-bischloromethyl-ether-human-health-carcinogen_.html

bis(2-ethylhexyl)phthalate (DEHP). September 8, 1998. **. 542-88-1. bis(chloromethyl)ether. December 7, 1990. ... ethylene glycol methyl ether. ethylene glycol methyl ether acetate *. *. *. *. *. August 13, 1999. February 10, 1999. August 13 ... methylene bis(2-chloroaniline), 4,4- (MOCA). January 8, 1999. 75-09-2. methylene chloride (or dichloromethane). June 1, 1990. ... bis(2-chloroethyl)ether (DCEE). December 7, 1990. 117-81-7. ... glycol ethers (and their acetates). ethylene glycol butyl ether ...

https://www.arb.ca.gov/drdb/sc/suphtml/1401_s_5-3-02.htm

bis (chloromethyl) ether; or. (3). the dust of uranium, or radon gas and its decay products; or. ...

https://www.worksafebc.com/en/law-policy/occupational-health-safety/searchable-ohs-regulation/workers-compensation-act/workers-compensation-act-schedules

Bis(2-ethylhexyl)phthalate(DEHP). 5. 542881. Bis(chloromethyl)ether. 0.0003. 75252. Bromoform. 10. ...

https://www.revisor.mn.gov/rules/7007.1300/version/2014-01-18T07:00:46-06:00

Bis (chloromethyl) ether. _Hydrazine. _1,3-Butadiene. _Methylene chloride (Dichloromethane). _Cadmium. _Nickel and nickel ...

https://www.arb.ca.gov/drdb/sd/suphtml/1200_s_2-02.htm

Bis(2-ethylhexyl)phthalate (DEHP). 542881. Bis(chloromethyl)ether. 75252. Bromoform. 106990 ... 2 Glycol ethers include mono- and di-ethers of ethylene glycol, diethylene glycol, and triethylene glycol R-(OCH2CH2)n-OR . ... Footnotes: For all listings in the table that contain the word compounds and for glycol ethers, the following applies: Unless ...

http://www.lrc.ky.gov/kar/401/063/060.htm

... ether; s-Di(chloromethyl) ether; Bis(chloromethyl) ether; Chloromethyl ether; Dichlorodimethyl ether; Oxybis[chloromethane]; ... Other names: Ether, bis(chloromethyl); «alpha»,«alpha»-Dichlorodimethyl ether; (Monochloromethyl) ... Bis-CME; Dichlordimethylaether; 1,1-Dichlorodimethyl ether; Dichlorodimethyl ether, symmetrical; sym-Dichloromethyl ether; ... Chloro(chloromethoxy) methane; sym-Dichloro-dimethyl ether; BCME; ...

https://webbook.nist.gov/cgi/cbook.cgi?ID=C542881

Bis(chloromethyl)-ether-3D-balls.png 2,188 × 1,000; 317 KB. *. Bis(chloromethyl)-ether-3D-spacefill.png 2,000 × 1,200; 330 KB. ... Media in category "Halogenated ethers". The following 25 files are in this category, out of 25 total. ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Halogenated_ethers&oldid=5681770" ...

https://commons.wikimedia.org/wiki/Category:Halogenated_ethers

Bis(chloromethyl) ether (BCME) is a man-made chemical with a strong, unpleasant odor. (cdc.gov)
Because BCME is broken down so rapidly in the possible health effects from drinking water or eating body, there are no specific tests to determine if a fish contaminated with bis(chloromethyl) ether. (cdc.gov)
Chloromethyl methyl ether (CMME) is almost invariably contaminated by bis(chloromethyl)ether (BCME), and the latter may be responsible for at least part of the observed carcinogenic activity. (inchem.org)
Initially, no doctors made the connection, but the trade union at the factory pursued the matter and found out that one of the chemicals used was bischloromethyl ether (BCME). (agius.com)

Asbestos, bis(chloromethyl)ether, nickel and wood dust had the strongest effect on cancer, with relative risks above 5. (bmj.com)
Additional risk factors include exposure to asbestos, radon, uranium mining, and bis-chloromethyl ether. (clinicaladvisor.com)
Cigarette smoking is the single leading cause of lung cancer, followed by environmental and occupational exposure to pollutants such as radon, arsenic, asbestos, Bis(chloromethyl) ether, chromium, nickel, vinyl chloride, and polycyclic aromatic compounds ( 2-4 ). (aacrjournals.org)

No exposure hazards were found for bis-chloromethyl-ether (542881), formaldehyde (50000), hydrochloric-acid (7647010), sulfur-dioxide (7446095), carbon-dioxide (124389), chromium (7440473), fluoride (16984488), fumes from iron-oxide (1309371), manganese (7439965) or copper (7440508). (cdc.gov)

The Department of Health and Human Services (DHHS) has determined that bis(chloromethyl) ether is a known human carcinogen. (cdc.gov)
Similarly, inadvertent mixing of formaldehyde (a common tissue fixative) and hydrogen chloride could result in the generation Of bis(chloromethyl) ether, a potent human carcinogen. (clemson.edu)
Chloromethyl ether is an alkylating agent which is a recognized human carcinogen. (noaa.gov)

NOTE: For all listings above which contain the word "compounds" and for glycol ethers, the following applies: Unless otherwise specified, these listings are defined as including any unique chemical substance that contains the named chemical (i.e., antimony, arsenic, etc.) as part of that chemical's infrastructure. (cornell.edu)

Bis(chloromethyl) ether is highly irritating to the skin, eyes, nose, throat, and lungs and it is a carcinogen. (cdc.gov)

chapter from the Toxicological Profile for BIS(CHLOROMETHYL) ETHER ? (cdc.gov)
Toxicological Profile for Bis (Chloromethyl) Ether (PB90-168691, 1989) 77 pp. (drugfuture.com)

Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. (wikipedia.org)

Bis(chloromethyl) ether was once produced on a large scale, but was found to be highly carcinogenic and thus such production has ceased. (wikipedia.org)
Because of their carcinogenic potency, the industrial production of chloromethyl ethers ended in most countries in the early 1980s. (wikipedia.org)
Bis(chloromethyl) ether is carcinogenic. (wikipedia.org)
Reagent for chloromethylation of Fmoc-protected amino acids without the generation of carcinogenic bis(chloromethyl)ether. (sigmaaldrich.com)

Bis(chloromethyl) ether is only used in small amounts inside fully enclosed systems to make other chemicals. (cdc.gov)
Bis(chloromethyl) ether released to air can be broken down by reactions with other chemicals and sunlight, or it can be removed by rain. (cdc.gov)
The most likely way to be exposed is by breathing it in the air if you work at, or live near, an industrial facility that makes or uses chemicals that may contain bis(chloromethyl) ether as a contaminant. (cdc.gov)

The Molecular Structure and Conformation of Dichloromethyl Methyl Ether, Cl2HC---O---CH3, in the Gas Phase. (actachemscand.dk)

The EPA recommends that levels in lakes and streams should be limited to 0.0000038 parts per billion parts of water (0.0000038 ppb) to prevent possible health effects from drinking water or eating fish contaminated with bis(chloromethyl) ether. (cdc.gov)

It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. (wikipedia.org)
Chloroalkyl ethers, N.O.S. (wa.gov)

Poly(arylene ethers) Polymer vol. 29, 1988, Feb. p. 358 P. M. Hergenrother, B. J. Jensen and S. J. Havens. (patentgenius.com)

DICHLORODIMETHYL ETHER is incompatible with the following: Acids, water [Note: Reacts with water to form hydrochloric acid & formaldehyde. (noaa.gov)

It is also produced as a byproduct in the Blanc chloromethylation reaction, formed when formaldehyde (the monomer, paraformaldehyde or formalin) and concentrated hydrochloric acid are mixed, and is a known impurity in technical grade chloromethyl methyl ether. (wikipedia.org)

Bis(chloromethyl) ether is an organic compound with the chemical formula (CH2Cl)2O. (wikipedia.org)
The Molecular Structure of Bis(chloromethyl) Ether, ClH2C--O--CH2Cl, in the Gas Phase. (actachemscand.dk)

Bis(chloromethyl) ether has been extensively used in chemical synthesis, primarily as a crosslinking agent in the manufacture of ion-exchange resins and in the textile industry. (wikipedia.org)

Opportunities to identify chemical carcinogens in human studies have been relatively infrequent and are limited to agents that have been studied in the workplace (e.g., bis-chloromethyl ether, vinyl chloride), following medical use (e.g., pharmaceuticals), or after accidental or catastrophic exposures (e.g., ionizing radiation). (wordpress.com)

However, small quantities of bis(chloromethyl) ether may be formed as an impurity during the production of another chemical, chloromethyl methyl ether. (cdc.gov)

There is evidence that bis(chloromethyl) ether causes lung cancer and other tumors in people and animals. (cdc.gov)

Only small quantities of bis(chloromethyl) ether are produced in the United States. (cdc.gov)

Bis(chloromethyl) ether has been found at 2 of the 1,518 National Priorities List sites identified by the Environmental Protection Agency (EPA). (cdc.gov)

A New Preparation of Chloromethyl Methyl Ether Free of Bis(chloromethyl) Ether. (patentgenius.com)

Transfers to Recycling by Monsanto Luling (TRI ID 70070MNSNTRIVER) for for Bis(chloromethyl) ether chemical, for All counties, U.S. (epa.gov)

Anatomy4

Organisms5

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes12

Information Science2

Tosyllysine Chloromethyl Ketone

Tosylphenylalanyl Chloromethyl Ketone

Bis(Chloromethyl) Ether

Amino Acid Chloromethyl Ketones

Ether

Ethers

Ethyl Ethers

Protease Inhibitors

Halogenated Diphenyl Ethers

Serine Proteinase Inhibitors

Phenyl Ethers

Isoflurophate

Crown Ethers

Phospholipid Ethers

Dansyl Compounds

Anhydrides

Glyceryl Ethers

Peptide Hydrolases

Trifluoroacetic Acid

Fluoroacetates

Pancreatic Elastase

Pyroglutamyl-Peptidase I

Serine Endopeptidases

Ketones

p-Chloromercuribenzoic Acid

Kinetics

Endopeptidases

Methyl Ethers

Tosyl Compounds

Substrate Specificity

Chymotrypsin

Molecular Weight

Ethylene Glycols

Alkylating Agents

Thrombin

Treponema

Trypsin Inhibitors

Polybrominated Biphenyls

Hydrogen-Ion Concentration

Cysteine Endopeptidases

Leupeptins

Phenylmethylsulfonyl Fluoride

Alkylation

Enzyme Precursors

Binding Sites

Porphyromonas gingivalis

Flame Retardants

Coumarins

Factor X

Hydrolysis

Electrophoresis, Polyacrylamide Gel

Structure-Activity Relationship

Affinity Labels

Trypsin

Amino Acid Sequence

NF-kappa B

Bacteroides

Cycloheximide

Cysteine Proteinase Inhibitors

Fluorescent Dyes

Molecular Sequence Data

Peptide Fragments

Cattle

Factor Xa

Ethers, Cyclic

Oligopeptides

Cysteine

Plasmalogens

Cell Line

Protein Precursors

Amino Acids

Chromatography, High Pressure Liquid

tert-Butyl Alcohol

Vinyl Compounds

Enzyme Activation

Dose-Response Relationship, Drug

Chromatography, Gel

Neutrophils

Cells, Cultured

Hydrocarbons, Brominated