Bis chloromethyl ether. Medical search

An inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process.

An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.

A substance that is an irritant to the eyes and respiratory tract and may be carcinogenic.

Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.

A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

Compounds that contain two halogenated benzene rings linked via an OXYGEN atom. Many polybrominated diphenyl ethers are used as FLAME RETARDANTS.

Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.

Ethers that are linked to a benzene ring structure.

A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.

Macrocyclic polyethers with the repeating unit of (-CH2-CH2-O)n where n is greater than 2 and some oxygens may be replaced by nitrogen, sulfur or phosphorus. These compounds are useful for coordinating CATIONS. The nomenclature uses a prefix to indicate the size of the ring and a suffix for the number of heteroatoms.

Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.

Compounds that contain a 1-dimethylaminonaphthalene-5-sulfonyl group.

Chemical compounds derived from acids by the elimination of a molecule of water.

Compounds in which one or more of the three hydroxyl groups of glycerol are in ethereal linkage with a saturated or unsaturated aliphatic alcohol; one or two of the hydroxyl groups of glycerol may be esterified. These compounds have been found in various animal tissue.

Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.

A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.

Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)

A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.

An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided the next residue is not proline. It is inhibited by thiol-blocking reagents and occurs in mammalian tissues, microorganisms, and plants. (From Enzyme Nomenclature, 1992) EC 3.4.19.3.

Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.

An organic mercurial used as a sulfhydryl reagent.

The rate dynamics in chemical or physical systems.

A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.

A group of compounds that contain the general formula R-OCH3.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.

The sum of the weight of all the atoms in a molecule.

An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

A genus of microorganisms of the order SPIROCHAETALES, many of which are pathogenic and parasitic for man and animals.

Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.

Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.

A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.

An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.

The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

Physiologically inactive substances that can be converted to active enzymes.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.

Materials applied to fabrics, bedding, furniture, plastics, etc. to retard their burning; many may leach out and cause allergies or other harm.

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.

Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.

The process of cleaving a chemical compound by the addition of a molecule of water.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.

Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.

Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.

Compounds of the general formula R-O-R arranged in a ring or crown formation.

Peptides composed of between two and twelve amino acids.

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.

GLYCEROPHOSPHOLIPIDS in which one of the two acyl chains is attached to glycerol with an ether alkenyl linkage instead of an ester as with the other glycerophospholipids.

Established cell cultures that have the potential to propagate indefinitely.

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.

Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

BCME (Bis(chloromethyl) ether) is associated with small cell lung cancer in workers who have been exposed. Exposure can occur ... "Bis(chloromethyl)ether (BCME) (CASRN 542-88-1)". IRIS (Integrated Risk Information System). EPA. 31 October 2014. Retrieved 31 ...

https://en.wikipedia.org/wiki/Occupational_lung_disease

Bis(chloromethyl) ether HN3 (nitrogen mustard) Lewisite Selenium mustard Sesquimustard "FM 3-8". Chemical Reference Handbook. ...

https://en.wikipedia.org/wiki/O-Mustard

... bis(chloromethyl) ether, and 10% tetrachloromethane. A later formulation, Gelbkreuz 1, was a mixture of 40% ethyldichloroarsine ... 40% ethyldibromoarsine, and 20% of bis(chloromethyl) ether. In some cases nitrobenzene was used to mask the material's ...

https://en.wikipedia.org/wiki/Yellow_Cross_(chemical_warfare)

... the production of small amounts of highly carcinogenic bis(chloromethyl) ether is a disadvantage for industrial applications. ... The reaction is performed with care as, like most chloromethylation reactions, it produces highly carcinogenic bis(chloromethyl ... Deactivated substrates give better results under modified chloromethylation conditions using chloromethyl methyl ether (MOMCl) ... H2O Chloromethylation can also be effected using chloromethyl methyl ether: ArH + CH3OCH2Cl → ArCH2Cl + CH3OH This reaction is ...

https://en.wikipedia.org/wiki/Blanc_chloromethylation

... the highly carcinogenic side product bis(chloromethyl) ether is not generated. Merck Index, 11th Edition, 5936 NIOSH Pocket ... This is a preferred method to using chloromethyl methyl ether (MOMCl). Alternatively, MOMCl can be prepared as a solution in a ... minimizing contact with the carcinogenic chloromethyl methyl ether. Unlike the classical procedure, which uses formaldehyde and ... 11, p. 934 "SYNTHESIS OF ALPHA-HALO ETHERS FROM SYMMETRIC ACETALS AND in situ METHOXYMETHYLATION OF AN ALCOHOL". orgsyn.org. ...

https://en.wikipedia.org/wiki/Dimethoxymethane

... chloromethyl) ether is a disadvantage for industrial applications. Dimethylformamide and phosphorus oxychloride in the ... Deactivated substrates are suitable for this reaction, although the production of small amounts of highly carcinogenic bis( ... Formylation of benzene rings could be accomplished by Blanc chloromethylation and a further oxidation of the chloromethyl group ... Chloroform in the Reimer-Tiemann reaction dichloromethyl methyl ether in Rieche formylation. Formylation of 3-methylamino-1- ...

https://en.wikipedia.org/wiki/Formylation_reaction

... methyl ether (technical grade), and bis-(chloromethyl) ether, mustard gas, MOPP (vincristine-prednisone-nitrogen mustard- ...

https://en.wikipedia.org/wiki/Lung_cancer

N-Bis(2-chloroethyl)-2-naphthylamine) Chlorambucil Bis(chloromethyl)ether Chloromethyl methyl ether Chromium(VI) (Hexavalent ...

https://en.wikipedia.org/wiki/IARC_group_1

... bis(chloromethyl) ether MeSH D02.355.601.400 - enflurane MeSH D02.355.601.536 - guaiacol MeSH D02.355.601.536.400 - guaifenesin ... glyceryl ethers MeSH D02.033.800.421.400.750 - phospholipid ethers MeSH D02.033.800.421.560 - nitroglycerin MeSH D02.033. ... tosyllysine chloromethyl ketone MeSH D02.455.426.559.389.832.710 - tosylphenylalanyl chloromethyl ketone MeSH D02.455.426.559. ... tosyllysine chloromethyl ketone MeSH D02.886.590.887.660 - tosylphenylalanyl chloromethyl ketone MeSH D02.886.640.150 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

The molecular formula C2H4Cl2O (molar mass: 114.96 g/mol, exact mass: 113.9639 u) may refer to: Bis(chloromethyl) ether ... Dichloromethyl methyl ether This set index page lists chemical structure articles associated with the same molecular formula. ...

https://en.wikipedia.org/wiki/C2H4Cl2O

Bis(chloromethyl) ether Blister agent Chlorine gas Half mustard Keen as Mustard Lewisite Nitrogen mustard Phosgene oxime Poison ... Other such compounds are bis(2-haloethyl)ethers (oxygen mustards), the (2-haloethyl)amines (nitrogen mustards), and ...

https://en.wikipedia.org/wiki/Mustard_gas

doi:10.1016/S0040-4020(99)00096-4. Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether CAS Nos. 542-88-1 and ... characterized as an ether connected to a chloromethyl group via an alkane chain. Chloromethyl methyl ether (CMME) is an ether ... chloromethyl) ether (BCME) (closely related to chemical weapon sulfur mustard) and benzyl chloromethyl ether (BOMCl). 2- ... Bis(Chloromethyl) ether Safety Data Sheet, Division of Occupational Health and Safety, US National Institutes of Health "Sigma- ...

https://en.wikipedia.org/wiki/Chloroalkyl_ether

... is considered as a potential carcinogen. Bis(chloromethyl) ether Sulfur mustard NIOSH Pocket Guide to ... Bis(chloroethyl) ether is an organic compound with the formula O(CH2CH2Cl)2. It is an ether with two 2-chloroethyl substituents ... Bis(chloroethyl) ether is less reactive than the corresponding sulfur mustard S(CH2CH2Cl)2. In the presence of base, it reacts ... When treated with strong base, it gives divinyl ether, an anesthetic: O(CH2CH2Cl)2 + 2 KOH → O(CH=CH2)2 + 2 KCl + 2 H2O The ...

https://en.wikipedia.org/wiki/Bis(chloroethyl)_ether

bis(Chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether CAS Nos. 542-88-1 and 107-30-2 Report on carcinogens, ... Chloromethyl methyl ether (CMME) is a compound with formula CH3OCH2Cl. A colorless liquid, it is a chloroalkyl ether. It is ... and hydrogen chloride yields material significantly contaminated with the dangerous bis(chloromethyl) ether and requires ... In all cases, a solution of chloromethyl methyl ether in toluene/methyl acetate was destroyed (to within detection limit) after ...

https://en.wikipedia.org/wiki/Chloromethyl_methyl_ether

... was no exception to this with production in the U.S.A. ending in 1982. Bis(chloromethyl) ether has been ... It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. Bis(chloromethyl) ether ... Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. "#0128". ... Chloromethylation of benzene and alkylbenzenes with bis(chloromethyl)ether, 1,4-bis(chloromethoxy)butane, 1-chloro-4- ...

https://en.wikipedia.org/wiki/Bis(chloromethyl)_ether

... chloride Chloroacetic acid 2-chloroethanol Chloroethyl chloroformate Chloroform Chloromethyl ether Chloromethyl methyl ether ... heptane-2-carbonitrile Bis(chloromethyl) ketone Bitoscanate Boron trichloride Boron trifluoride Boron trifluoride compound with ... 3-bis(chloromethyl)- Oxydisulfoton Paraquat Paraquat methosulfate Parathion Parathion-methyl Paris green Pentaborane ... bis(1-methylethyl)amino)ethyl) O-ethyl ester Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester Phosphoric acid, ...

https://en.wikipedia.org/wiki/EPA_list_of_extremely_hazardous_substances

3-bis(chloromethyl)benzo[c] thiophene 2,2-dioxide (0.584 g, 2.2 mmol) in 50 ml of dry benzene was added 0.80 mL (2.8 mmol) of a ... 10)). Ether cleavage is difficult to accomplish with most hydride reagents. However, debenzylation of benzyl aryl ethers may be ... The most common solvents used are tetrahydrofuran and diethyl ether. Whatever solvent is used should be anhydrous and pure. ... In a related application, NaAlH2(OCH2CH2OCH3)2 (sodium bis(methoxyethoxy) aluminium dihydride, SMEAH or Red-Al) reacts with ...

https://en.wikipedia.org/wiki/Reductions_with_metal_alkoxyaluminium_hydrides

Bis(2-chloroethylthio) methane Bis(2-chloroethylthiomethyl) ether Bis(2-chloroethylthioethyl) ether (O Mustard; T) ... Chloromethyl chloroformate Dibenzoxazepine (CR) Ethyl iodoacetate Ortho-chlorobenzylidene malononitrile (Super tear gas; CS) ... Bis(2-chloroethyl)ethylamine (HN1) Bis(2-chloroethyl)methylamine (HN2) Tris(2-chloroethyl)amine (HN3) 1,2-Bis(2-chloroethylthio ... 4-Bis(2-chloroethylthio)-n-butane 1,5-Bis(2-chloroethylthio)-n-pentane 2-Chloroethylchloromethylsulfide Bis(2-chloroethyl) ...

https://en.wikipedia.org/wiki/List_of_chemical_warfare_agents

For example, enol ethers like trimethylsilyloxy-substituted olefins are often used because of the high yields obtained. Despite ... Denmark, S. E.; Edwards, J. P. (1991). "A Comparison of (Chloromethyl)- and (Iodomethyl)zinc Cyclopropanation Reagents". J. Org ... Cyclopropan-Bildung aus Olefinen mit Bis-halogenmethyl-zink". Chemische Berichte. 97 (8): 2146-2164. doi:10.1002/cber. ... The modification was proposed in 1968 as a way to turn cationically polymerizable olefins such as vinyl ethers into their ...

https://en.wikipedia.org/wiki/Simmons–Smith_reaction

Smith, A. P.; Lamba, J. J. S.; Fraser, C. L. (2004). "Efficient Synthesis of Halomethyl-2,2'-Bipyridines: 4,4'-Bis(chloromethyl ... As such it is commercially available as a solution in polar aprotic solvents such as THF and ether; however, for small scale ... Lithium amide Lithium bis(trimethylsilyl)amide (LiHMDS) Lithium tetramethylpiperidide (LiTMP) Evans pKa Table Hamell, Matthew; ...

https://en.wikipedia.org/wiki/Lithium_diisopropylamide

The Quelet reaction (also called the Blanc-Quelet reaction) is an organic coupling reaction in which a phenolic ether reacts ... R. Quelet (1932). "preparation d'un derive chloro-methyl du para-bromo-anisol (methoxy-2 bromo-2 α-chlorotoluene)". Compt. Rend ... Sugawasa, Shigehiko; Fuijsawa, Toshiro; Okada, Kozo (1952). "Synthesis of 2,2-Polymethylene-bis-(Py-tetrahydroisoquinoline) ... The Quelet reaction can produce dangerous halomethyl ethers, gaseous and liquid compounds that are toxic to humans, and ...

https://en.wikipedia.org/wiki/Quelet_reaction

Silyl ethers have the connectivity Si-O-C. They are typically prepared by the reaction of alcohols with silyl chlorides: (CH3) ... Commun., 2002, (4), 348-349 doi:10.1039/b109816k Mechanistic insight into copper-catalysed allylic substitutions with bis( ... More specialized derivatives that find commercial applications include dichloromethylphenylsilane, trichloro(chloromethyl) ... are used in deprotection of silyl ethers: (CH3)3Si-O-R + F− + H2O → (CH3)3Si-F + H-O-R + OH− Organosilyl chlorides are ...

https://en.wikipedia.org/wiki/Organosilicon_compound

Worker exposures to benzene (71432), bis-chloromethyl-ether (542881), 2,6-ditert-butyl-p-cresol (128370), carbon-monoxide ( ... Bis-Chloromethyl Ether; 2,6-Ditert-Butyl-P-Cresol; BHT; Carbon Monoxide; Formaldehyde; Hydrogen Chloride; Hydrogen Cyanide; ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=hydrogen cyanide&f1=*&Adv=0&terms=1&PageNo=9&RecNo=89&View=f&

Hazard review of bis(chloromethyl)ether (BCME). Authors. Lassiter DV Source. NIOSH 1973 Jun; :1-14 ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=hydrogen chloride&f1=*&Adv=0&terms=1&PageNo=151&RecNo=151&View=b&

Bis-chloromethyl-ether was not detected in any samples. The authors conclude that noise levels were below average, and ...

http://www2.cdc.gov/nioshtic-2/BuildQyr.asp?s1=noise*&f1=*&s2=&PageNo=292&RecNo=2911&View=f&

bis-Chloromethyl ether. 542-88-1. 0128.pdf pdf icon. No Revision. ... Isopropyl ether. 108-20-3. 0362.pdf pdf icon. No Revision. Isopropyl glycidyl ether. 4016-14-2. 0363.pdf pdf icon. No Revision ... Chloromethyl methyl ether. 107-30-2. 0129.pdf pdf icon. No Revision. ... Dichloroethyl ether. 111-44-4. 0196.pdf pdf icon. No Revision. Dichloromonofluoromethane. 75-43-4. 0197.pdf pdf icon. No ...

https://www.cdc.gov/niosh/docs/81-123/default.html

... bis- chloromethyl-ether (107302), chromium (7440473), beryllium (7440417), and cadmium (7440439). Major findings and ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=chromium&f1=*&Adv=0&terms=1&PageNo=32&RecNo=312&View=f&

Bis(Chloromethyl) et... * Dose-response relati... * Environmental exposu... * Methacrylates * Occupational exposur... * Show ... Selected chloroalkyl ethers. by Liteplo, R , Gomes, R , World Health Organization , International Programme on Chemical Safety. ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=ccl=copydate:"1998)."&sort_by=relevance_dsc&count=20&limit=au:Gomes, R.

Hazard review of bis(chloromethyl)ether (BCME). Authors. Lassiter DV Source. NIOSH 1973 Jun; :1-14 ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=skin&t3=1&f1=*&s5=percutaneous&Startyear=&t1=1&s2=dermal&t4=1&terms=7&Adv=1&ct=&B1=Search&f2=*&t2=1&Limit=500&Sort=DP DESC&s3=dermatitis&f3=*&s4=cutaneous&EndYear=&f4=*&f5=*&whichdate=DP&D1=10&PageNo=4202&RecNo=4202&View=b&

No exposure hazards were found for bis-chloromethyl-ether (542881), formaldehyde (50000), hydrochloric-acid (7647010), sulfur- ... Bis-Chloromethyl Ether; Calcium Oxide; Hexavalent Chromium; Nickel; Ultraviolet Radiation ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=welding&f1=*&Startyear=&Adv=0&terms=1&D1=10&EndYear=&Limit=10000&sort=&PageNo=81&RecNo=810&View=f&

Bis(chloromethyl) ether is highly irritating to the skin, eyes, nose, throat, and lungs and it is a carcinogen. Bis( ... chloromethyl) ether is only used in small amounts inside fully enclosed systems to make other chemicals. Use of this chemical ... chloromethyl) ether has been found at 2 of the 1,518 National Priorities List sites identified by the Environmental Protection ... ether?. There are no specific tests to show if you have been exposed to bis(chloromethyl) ether. Bis(chloromethyl) ether breaks ...

https://wwwn.cdc.gov/TSP/ToxFAQs/ToxFAQsDetails.aspx?faqid=918&toxid=188

Bis(chloromethyl)ether. CAS No: 542-88-1. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references ... Bis(chloromethyl)ether. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ... 2005-110) - Bis(chloromethyl)ether ...

https://www.cdc.gov/niosh/docs/2005-110/nmed0026.html

Bis(chloromethyl) ether was no exception to this with production in the U.S.A. ending in 1982. Bis(chloromethyl) ether has been ... It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. Bis(chloromethyl) ether ... Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. "#0128". ... Chloromethylation of benzene and alkylbenzenes with bis(chloromethyl)ether, 1,4-bis(chloromethoxy)butane, 1-chloro-4- ...

https://en.wikipedia.org/wiki/Bis(chloromethyl)_ether

Selected chloroalkyl ethers Liteplo, R; Gomes, R; World Health Organization; International Programme on Chemical Safety (‎ ... Browsing by Subject "Bis(‎Chloromethyl)‎ Ether". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y ...

https://extranet.who.int/iris/restricted/browse?authority=Bis%28Chloromethyl%29+Ether&type=mesh

BIS(CHLOROMETHYL)ETHER. 602. 542-88-1. 244. CARBOPHENOTHION. 602. 786-19-6. ...

https://www.atsdr.cdc.gov/spl/index.html

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=hydrogen+cyanide&f1=%2A&Adv=0&terms=1&PageNo=9&RecNo=89&View=f&

Bis(Chloromethyl)Ether Chloromethyl Ether Dichloromethyl Ether Registry Number. 77382IHE37. Related Numbers. 542-88-1. CAS Type ... use BIS(CHLOROMETHYL) ETHER to search DICHLOROMETHYL ETHER 1975-78. History Note. 91(79); was see under METHYL ETHERS 1979-90; ... Bis(Chloromethyl) Ether Preferred Term Term UI T005031. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bis(Chloromethyl) Ether Preferred Concept UI. M0002605. Registry Number. 77382IHE37. Related Numbers. 542-88-1. Scope Note. A ...

https://meshb.nlm.nih.gov/record/ui?ui=D001725

Bis-chloromethyl-ether was not detected in any samples. The authors conclude that noise levels were below average, and ...

http://www2.cdc.gov/nioshtic-2/BuildQyr.asp?s1=noise%2A&f1=%2A&s2=&PageNo=292&RecNo=2911&View=f&

bis(chloromethyl)ether (BCME). 00542-88-1. bromine. 07726-95-6. bromine pentafluoride. 07789-30-2. ...

https://codes.ohio.gov/ohio-administrative-code/rule-3745-114-01

bis(2-(Dimethylamino)ethyl)ether. Formula: C8H20N2O [(CH3)2NCH2CH2OCH2CH2N(CH3)2]. *bis-Chloromethyl ether. Formula: (CH2Cl)2O ... Chloromethyl methyl ether. Formula: CH3OCH2Cl. *Chloroprene. Formula: CH2=CClCH=CH2. *Chlorpyrifos. Formula: C9H11Cl3NO3PS. * ... Phenyl ether (vapor). Formula: C6H5OC6H5. *Phenyl ether-biphenyl mixture (vapor). Formula: C6H5OC6H5/C6H5C6H5. *Phenyl glycidyl ... Isopropyl ether. Formula: (CH3)2CHOCH(CH3)2. *Isopropyl glycidyl ether. Formula: C6H12O2. *Isopropylamine. Formula: (CH3)2CHNH2 ...

https://environmentalchemistry.com/yogi/periodic/Sn-compounds.html

Bis(chloromethyl)ether - 542-88-1 - Toxicity: cancer. *Bis(2-chloro-1-methylethyl)ether, technical grade - Toxicity: cancer ... Bis(2-chloroethyl)ether - 111-44-4 - Toxicity: cancer. *N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) - 494-03-1 - ... Chloromethyl methyl ether (technical grade) - 107-30-2 - Toxicity: cancer. *3-Chloro-2-methylpropene - 563-47-3 - Toxicity: ... 4,4-Methylene bis(2-chloroaniline) - 101-14-4 - Toxicity: cancer. *4,4-Methylene bis(N,N-dimethyl)benzenamine - 101-61-1 - ...

https://caslab.com/Proposition-65-List/?setCurrencyId=3

Bis(chloromethyl) ether 542-88-1 1,000. Borane, trichloro- 10294-34-5 5,000. Borane, trifluoro- 7637-07-2 5,000. Boron ... Chloromethyl ether 542-88-1 1,000. Chloromethyl methyl ether 107-30-2 5,000. Crotonaldehyde 4170-30-3 20,000. Crotonaldehyde, ( ... Vinyl ethyl ether 109-92-2 10,000. Vinyl fluoride 75-02-5 10,000. Vinyl methyl ether 107-25-5 10,000. Vinylidene chloride 75-35 ... Ethyl ether 60-29-7 10,000. Ethyl mercaptan 75-08-1 10,000. Ethyl nitrite 109-95-5 10,000. Ethylene 74-85-1 10,000. Ethylene ...

https://www.ehso.com/RMPCAA112rlist.htm

Chronic inhalational exposure to some agents (eg, bis[chloromethyl]ether, certain metals) causes lung and other cancers (eg, ...

https://www.merckmanuals.com/en-ca/professional/pulmonary-disorders/environmental-pulmonary-diseases/irritant-gas-inhalation-injury

... chloromethyl)oxirane and 4,4-(1-methylethylidene)bis[phenol], Ph ethers. ...

https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/27217/4/2

... chloromethyl)oxirane and 4,4-(1-methylethylidene)bis[phenol], Ph ethers. ...

https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/27217/7/5/2

... the substance was contaminated to form bis chloromethyl ether (BCME).. 2. Again, the issue is the same as that in the EI appeal ... The thrust of the opposition to the standard regulating chloromethyl methyl ether (CMME) is aimed at certain studies relied ... In summary then, the regulations applicable to 4,4 methylene bis (2-chloroaniline) (MOCA) will be remanded for the publication ... Polyurethane Manufacturers Association (PMA), the employers association concerned with the use of 4,4 methylene bis (2- ...

https://www.leagle.com/decision/1974891506f2d3851846

Bis(chloromethyl) Ether FromATSDR Toxic Substances Portal Bromodichloromethane FromATSDR Toxic Substances Portal ...

https://phgkb.cdc.gov/PHGKB/cDCInfoFinder.action?Mysubmit=init&query=all&dbTypeChoice=PGx&dbChoice=CDC

... lung cancer in workers exposed to bis-chloromethyl ether used in plexiglass manufacture, mesothelioma and lung cancer in ...

http://www.toxictorts.com/chemically-induced-cancer/

Bis-chloro methyl ether Current Synonym true false 7490013 bis-Chloro methyl ether Current Synonym true false ... Bis-chloro methyl ether (substance). Code System Preferred Concept Name. Bis-chloro methyl ether (substance). ...

https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=3854006

Bis(2-chloroethyl) Ether. *Bis(chloromethyl) Ether. *Boron. *Bromodichloromethane. *Bromoform & Dibromochloromethane. * ...

https://emergency.cdc.gov/chemical/toxprofiles.asp

... bis-chloromethyl ether.. 5. 2-Mercaptoethanol (\beta-Mercaptoethanol, BME). As if the smell of rotten fish wasnt bad enough, 2 ...

https://bitesizebio.com/10470/ten-bad-chemicals-in-the-lab-and-what-they-do-to-you/

bis (chloromethyl) ether. BCNP. Board Certified Nuclear Pharmacist. BCNU. BCNU is another name for Carmustine. ...

https://www.newmedicalterms.com/abbreviation/b/

Bis(2-ethylhexyl)phthalate (DEHP). 542881. Bis(chloromethyl)ether. 75252. Bromoform. 106990. 1,3-Butadiene. ... R = R, H, or groups which, when removed, yield glycol ethers with the structure: R-(OCH2CH)n-OH. Polymers are excluded from ... 2 Includes mono- and di- ethers of ethylene glycol, diethylene glycol, and triethylene glycol R-(OCH2CH2)n-OR where ... NOTE: For all listings above which contain the word "compounds" and for glycol ethers, the following applies: Unless otherwise ...

https://casetext.com/statute/united-states-code/title-42-the-public-health-and-welfare/chapter-85-air-pollution-prevention-and-control/subchapter-i-programs-and-activities/part-a-air-quality-and-emission-limitations/section-7412-hazardous-air-pollutants

Chlornapazine (N,N-Bis(2-chloroethyl)-2-naphthylamine). 51. Bis(chloromethyl)ether ...

https://ktwop.com/tag/who/

96. BIS (CHLOROMETHYL) ETHER [ԲԻՍ-ՔԼՈՐՄԵԹԻԼԱՅԻՆ ԵԹԵՐ] 47. BIOFLAVONOIDS [ԿԵՆՍԱՖԼԱՎՈՆՈԻԴՆԵՐ] 97. BISACODYL [ԲԻՍԱԿՈԴԻԼ] ... BIA BIB BIC BIF BIG BIL BIN BIO BIP BIR BIS BIT BIU. ... B- BA BC BE BH BI BK BL BO BR BU BY. ...

https://medindex.am/glossary/index.php/list/English-Armenian+Medical/,B,I,.xhtml

Bis(2-chloroethyl) Ether. *Bis(chloromethyl) Ether. *Boron. *Bromodichloromethane. *Bromoform & Dibromochloromethane. * ...

https://www.emergency.cdc.gov/chemical/toxprofiles.asp

Methyl Chloromethyl Ether. * 3,3 Dichlorobenzine (and its salt). * Bis-Chloromethyl Ether ...

https://wiki.unmc.edu/index.php?title=Medical_Surveillance&diff=next&oldid=9365

... and adding bis(chloromethyl) ether (BCME) and chloromethyl methyl ether (CMME). Over the years, the Regulations have been ... Bis(chloromethyl) ether, which has the molecular formula C2H4Cl2O. ... Chloromethyl methyl ether, which has the molecular formula C2H5ClO. ... Conditions - decabromodiphenyl ether. 8 (1) If the toxic substance is decabromodiphenyl ether referred to in item 15, column 1 ...

https://www.canadagazette.gc.ca/rp-pr/p1/2022/2022-05-14/html/reg2-eng.html

The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. (rapp-polymere.com)

The employers contest the validity of the Van Duuren studies 1 by questioning whether pure CMME was tested or whether, as usually occurs, the substance was contaminated to form bis chloromethyl ether (BCME). (leagle.com)
Mixingwith formaldehyde results in the evolution of chlorine gas, fomic acid, hydrochloric acid fumes , chlorine oxidesand possibly other hazardous by-products of chemical interaction, such as BCME (bis-chloromethyl ether), avery dangerous, neurotoxic gas. (magicsnewbiewines.com)

It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. (wikipedia.org)

Chloromethyl menthyl ether, 95%, 97% e.e. (agricheme.com)

The International Agency for Research on Cancer (IARC) has concluded that bis(chloromethyl) ether is carcinogenic to humans. (cdc.gov)
Bis(chloromethyl) ether was once produced on a large scale, but was found to be highly carcinogenic and thus such production has ceased. (wikipedia.org)
Because of their carcinogenic potency, the industrial production of chloromethyl ethers ended in most countries in the early 1980s. (wikipedia.org)
Bis(chloromethyl) ether is carcinogenic. (wikipedia.org)

2-Propenoic acid, polymers with bisphenol A diglycidyl ether and oxirane mono[(C10-16-alkyloxy)methyl] derivs. (ckspharm.com)

It is also produced as a byproduct in the Blanc chloromethylation reaction, formed when formaldehyde (the monomer, paraformaldehyde or formalin) and concentrated hydrochloric acid are mixed, and is a known impurity in technical grade chloromethyl methyl ether. (wikipedia.org)
And don't buffer formaldehyde with hydrochloric acid, because together they form a potent carcinogen, bis-chloromethyl ether. (bitesizebio.com)

4241. 1 Dipentyl ether 190 Ethylene glycol dibutyl ether 203. (qrforex.com)

The U.S. Department of Health and Human Services (DHHS) has classified bis(chloromethyl) ether as a known human carcinogen (causing cancer in people). (cdc.gov)
The U.S. Environmental Protection Agency (EPA) has determined that bis(chloromethyl) ether is a known human carcinogen. (cdc.gov)
The Department of Health and Human Services (DHHS) has determined that bis (chloromethyl) ether is a known human carcinogen. (cancereffects.com)

Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. (wikipedia.org)

Studies have shown breathing bis(chloromethyl) ether during work causes lung cancer in some people. (cdc.gov)
Among these are lung cancer in uranium miners, sarcoma of the jaw in radium dial painters, bladder cancer in workers exposed to aromatic amines, angiosarcoma of the liver in vinyl chloride workers, lung cancer in workers exposed to bis-chloromethyl ether used in plexiglass manufacture, mesothelioma and lung cancer in workers exposed to asbestos, and leukemia and other hematopoietic cancers in benzene-exposed workers. (toxictorts.com)
Chloromethyl ether - studies has shown thatbis(chloromethyl) ether can cause lung cancer and other malignant tumors in people and animals. (cancereffects.com)

Polyurethane Manufacturers Association (PMA), the employers' association concerned with the use of 4,4' methylene bis (2-chloroaniline) (MOCA) 3 in various manufacturing processes, presses the same arguments as to carcinogenicity that are advanced for DCB and CMME. (leagle.com)

The small quantities of bis(chloromethyl) ether that are produced in the United States are only used in enclosed systems to make other chemicals. (cdc.gov)

In the past, Bis(chloromethyl) ether was used to make several types of polymers, resins, and textiles, but these uses have stopped. (cdc.gov)

For example, bis(triethoxysilyl)ethene ( BTES-E2 )- and bis(triethoxysilyl)ethyne ( BTES-E3 )-derived membranes were found to exhibit increased water permeance compared with bis(triethoxysilyl)ethane ( BTES-E1 )-derived membranes. (nature.com)

VIO Chemicals offers a broad range of Intermediates for API synthesis, including 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine HCl for the synthesis of Lansoprazole and Dexlansprazole APIs. (cphi-online.com)
Arch Chemicals, Inc. submitted revisions/updates to the robust summaries and test plans for Hydroquinone bis(2-hydroxyethyl) Ether . (webharvest.gov)

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). (lookchem.com)

The first reaction is O-alkylation of p-cresol to give a 4-methylphenyl allyl ether derivative 3. (stackexchange.com)

Additional risk factors include exposure to asbestos, radon, uranium mining, and bis-chloromethyl ether. (dermatologyadvisor.com)

It is a clear liquid with various grades having different boiling points, that is insoluble in water and soluble in alcohol and ether,and used in aviation gasoline, coatings, lacquers, rubber cements, organic synthesis, and polyester resin manufacture. (chemicalbook.com)

The thrust of the opposition to the standard regulating chloromethyl methyl ether (CMME) is aimed at certain studies relied upon by the Secretary. (leagle.com)

Workers exposed to air containing bis(chloromethyl) ether had coughing, bronchitis, and difficulty breathing. (cdc.gov)

1,3-bis(2-methylphenyl)guanidine: form recommended by the IUPAC (International Union of Pure and Applied Chemistry). (gc.ca)

Bis(chloromethyl) ether has been extensively used in chemical synthesis, primarily as a crosslinking agent in the manufacture of ion-exchange resins and in the textile industry. (wikipedia.org)

Most people are very unlikely to come into contact with bis(chloromethyl) ether. (cdc.gov)

Bis(chloromethyl) ether does not accumulate (build up) in plants or animals. (cdc.gov)
In animals, breathing bis(chloromethyl) ether caused breathing problems and lung damage. (cdc.gov)
Nose and lung cancers were also seen in animals after they breathed bis(chloromethyl) ether for short or long periods of time. (cdc.gov)

Can I get a medical test to check for bis(chloromethyl) ether? (cdc.gov)

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. (lookchem.com)

2017. Toxicological Profile for Bis(chloromethyl) ether . (cdc.gov)

Bis(chloromethyl) ether dissolves easily in water. (cdc.gov)
In water, bis(chloromethyl) ether dissolves and is very quickly broken-down. (cdc.gov)
Pencil hardness tests and water contact angle measurements of the BTES-MAz film surface were performed to show that the surface of this film was softer and more hydrophobic than that of film prepared from bis(triethoxysilyl)ethane ( BTES-E1 ). (nature.com)

Bis(chloromethyl) ether was no exception to this with production in the U.S.A. ending in 1982. (wikipedia.org)

Anatomy4

Organisms5

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes12

Information Science2

Tosyllysine Chloromethyl Ketone

Tosylphenylalanyl Chloromethyl Ketone

Bis(Chloromethyl) Ether

Amino Acid Chloromethyl Ketones

Ether

Ethers

Ethyl Ethers

Protease Inhibitors

Halogenated Diphenyl Ethers

Serine Proteinase Inhibitors

Phenyl Ethers

Isoflurophate

Crown Ethers

Phospholipid Ethers

Dansyl Compounds

Anhydrides

Glyceryl Ethers

Peptide Hydrolases

Trifluoroacetic Acid

Fluoroacetates

Pancreatic Elastase

Pyroglutamyl-Peptidase I

Serine Endopeptidases

Ketones

p-Chloromercuribenzoic Acid

Kinetics

Endopeptidases

Methyl Ethers

Tosyl Compounds

Substrate Specificity

Chymotrypsin

Molecular Weight

Ethylene Glycols

Alkylating Agents

Thrombin

Treponema

Trypsin Inhibitors

Polybrominated Biphenyls

Hydrogen-Ion Concentration

Cysteine Endopeptidases

Leupeptins

Phenylmethylsulfonyl Fluoride

Alkylation

Enzyme Precursors

Binding Sites

Porphyromonas gingivalis

Flame Retardants

Coumarins

Factor X

Hydrolysis

Electrophoresis, Polyacrylamide Gel

Structure-Activity Relationship

Affinity Labels

Trypsin

Amino Acid Sequence

NF-kappa B

Bacteroides

Cycloheximide

Cysteine Proteinase Inhibitors

Fluorescent Dyes

Molecular Sequence Data

Peptide Fragments

Cattle

Factor Xa

Ethers, Cyclic

Oligopeptides

Cysteine

Plasmalogens

Cell Line

Protein Precursors

Amino Acids

Chromatography, High Pressure Liquid

tert-Butyl Alcohol

Vinyl Compounds

Enzyme Activation

Dose-Response Relationship, Drug

Chromatography, Gel

Neutrophils

Cells, Cultured

Hydrocarbons, Brominated