Tosyllysine Chloromethyl Ketone
Tosylphenylalanyl Chloromethyl Ketone
Bis(Chloromethyl) Ether
Amino Acid Chloromethyl Ketones
Ether
Protease Inhibitors
Halogenated Diphenyl Ethers
Isoflurophate
Crown Ethers
Macrocyclic polyethers with the repeating unit of (-CH2-CH2-O)n where n is greater than 2 and some oxygens may be replaced by nitrogen, sulfur or phosphorus. These compounds are useful for coordinating CATIONS. The nomenclature uses a prefix to indicate the size of the ring and a suffix for the number of heteroatoms.
Phospholipid Ethers
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
Glyceryl Ethers
Peptide Hydrolases
Trifluoroacetic Acid
Fluoroacetates
Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)
Pancreatic Elastase
Pyroglutamyl-Peptidase I
Serine Endopeptidases
Endopeptidases
Substrate Specificity
Chymotrypsin
Ethylene Glycols
Alkylating Agents
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Treponema
Trypsin Inhibitors
Polybrominated Biphenyls
Hydrogen-Ion Concentration
Cysteine Endopeptidases
Leupeptins
Phenylmethylsulfonyl Fluoride
Alkylation
Binding Sites
Porphyromonas gingivalis
Flame Retardants
Coumarins
Factor X
Electrophoresis, Polyacrylamide Gel
Structure-Activity Relationship
Affinity Labels
Trypsin
Amino Acid Sequence
NF-kappa B
Bacteroides
Cycloheximide
Cysteine Proteinase Inhibitors
Fluorescent Dyes
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Peptide Fragments
Cattle
Factor Xa
Plasmalogens
Amino Acids
Chromatography, High Pressure Liquid
Enzyme Activation
Dose-Response Relationship, Drug
Chromatography, Gel
Neutrophils
Cells, Cultured
Rabbits
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Occupational lung disease
BCME (Bis(chloromethyl) ether) is associated with small cell lung cancer in workers who have been exposed. Exposure can occur ... "Bis(chloromethyl)ether (BCME) (CASRN 542-88-1)". IRIS (Integrated Risk Information System). EPA. 31 October 2014. Retrieved 31 ...
O-Mustard
Bis(chloromethyl) ether HN3 (nitrogen mustard) Lewisite Selenium mustard Sesquimustard "FM 3-8". Chemical Reference Handbook. ...
Yellow Cross (chemical warfare)
... bis(chloromethyl) ether, and 10% tetrachloromethane. A later formulation, Gelbkreuz 1, was a mixture of 40% ethyldichloroarsine ... 40% ethyldibromoarsine, and 20% of bis(chloromethyl) ether. In some cases nitrobenzene was used to mask the material's ...
Blanc chloromethylation
... the production of small amounts of highly carcinogenic bis(chloromethyl) ether is a disadvantage for industrial applications. ... The reaction is performed with care as, like most chloromethylation reactions, it produces highly carcinogenic bis(chloromethyl ... Deactivated substrates give better results under modified chloromethylation conditions using chloromethyl methyl ether (MOMCl) ... H2O Chloromethylation can also be effected using chloromethyl methyl ether: ArH + CH3OCH2Cl → ArCH2Cl + CH3OH This reaction is ...
Dimethoxymethane
... the highly carcinogenic side product bis(chloromethyl) ether is not generated. Merck Index, 11th Edition, 5936 NIOSH Pocket ... This is a preferred method to using chloromethyl methyl ether (MOMCl). Alternatively, MOMCl can be prepared as a solution in a ... minimizing contact with the carcinogenic chloromethyl methyl ether. Unlike the classical procedure, which uses formaldehyde and ... 11, p. 934 "SYNTHESIS OF ALPHA-HALO ETHERS FROM SYMMETRIC ACETALS AND in situ METHOXYMETHYLATION OF AN ALCOHOL". orgsyn.org. ...
Formylation reaction
... chloromethyl) ether is a disadvantage for industrial applications. Dimethylformamide and phosphorus oxychloride in the ... Deactivated substrates are suitable for this reaction, although the production of small amounts of highly carcinogenic bis( ... Formylation of benzene rings could be accomplished by Blanc chloromethylation and a further oxidation of the chloromethyl group ... Chloroform in the Reimer-Tiemann reaction dichloromethyl methyl ether in Rieche formylation. Formylation of 3-methylamino-1- ...
Lung cancer
... methyl ether (technical grade), and bis-(chloromethyl) ether, mustard gas, MOPP (vincristine-prednisone-nitrogen mustard- ...
IARC group 1
N-Bis(2-chloroethyl)-2-naphthylamine) Chlorambucil Bis(chloromethyl)ether Chloromethyl methyl ether Chromium(VI) (Hexavalent ...
List of MeSH codes (D02)
... bis(chloromethyl) ether MeSH D02.355.601.400 - enflurane MeSH D02.355.601.536 - guaiacol MeSH D02.355.601.536.400 - guaifenesin ... glyceryl ethers MeSH D02.033.800.421.400.750 - phospholipid ethers MeSH D02.033.800.421.560 - nitroglycerin MeSH D02.033. ... tosyllysine chloromethyl ketone MeSH D02.455.426.559.389.832.710 - tosylphenylalanyl chloromethyl ketone MeSH D02.455.426.559. ... tosyllysine chloromethyl ketone MeSH D02.886.590.887.660 - tosylphenylalanyl chloromethyl ketone MeSH D02.886.640.150 - ...
C2H4Cl2O
The molecular formula C2H4Cl2O (molar mass: 114.96 g/mol, exact mass: 113.9639 u) may refer to: Bis(chloromethyl) ether ... Dichloromethyl methyl ether This set index page lists chemical structure articles associated with the same molecular formula. ...
Mustard gas
Bis(chloromethyl) ether Blister agent Chlorine gas Half mustard Keen as Mustard Lewisite Nitrogen mustard Phosgene oxime Poison ... Other such compounds are bis(2-haloethyl)ethers (oxygen mustards), the (2-haloethyl)amines (nitrogen mustards), and ...
Chloroalkyl ether
doi:10.1016/S0040-4020(99)00096-4. Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether CAS Nos. 542-88-1 and ... characterized as an ether connected to a chloromethyl group via an alkane chain. Chloromethyl methyl ether (CMME) is an ether ... chloromethyl) ether (BCME) (closely related to chemical weapon sulfur mustard) and benzyl chloromethyl ether (BOMCl). 2- ... Bis(Chloromethyl) ether Safety Data Sheet, Division of Occupational Health and Safety, US National Institutes of Health "Sigma- ...
Bis(chloroethyl) ether
... is considered as a potential carcinogen. Bis(chloromethyl) ether Sulfur mustard NIOSH Pocket Guide to ... Bis(chloroethyl) ether is an organic compound with the formula O(CH2CH2Cl)2. It is an ether with two 2-chloroethyl substituents ... Bis(chloroethyl) ether is less reactive than the corresponding sulfur mustard S(CH2CH2Cl)2. In the presence of base, it reacts ... When treated with strong base, it gives divinyl ether, an anesthetic: O(CH2CH2Cl)2 + 2 KOH → O(CH=CH2)2 + 2 KCl + 2 H2O The ...
Chloromethyl methyl ether
bis(Chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether CAS Nos. 542-88-1 and 107-30-2 Report on carcinogens, ... Chloromethyl methyl ether (CMME) is a compound with formula CH3OCH2Cl. A colorless liquid, it is a chloroalkyl ether. It is ... and hydrogen chloride yields material significantly contaminated with the dangerous bis(chloromethyl) ether and requires ... In all cases, a solution of chloromethyl methyl ether in toluene/methyl acetate was destroyed (to within detection limit) after ...
Bis(chloromethyl) ether
... was no exception to this with production in the U.S.A. ending in 1982. Bis(chloromethyl) ether has been ... It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. Bis(chloromethyl) ether ... Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. "#0128". ... Chloromethylation of benzene and alkylbenzenes with bis(chloromethyl)ether, 1,4-bis(chloromethoxy)butane, 1-chloro-4- ...
EPA list of extremely hazardous substances
... chloride Chloroacetic acid 2-chloroethanol Chloroethyl chloroformate Chloroform Chloromethyl ether Chloromethyl methyl ether ... heptane-2-carbonitrile Bis(chloromethyl) ketone Bitoscanate Boron trichloride Boron trifluoride Boron trifluoride compound with ... 3-bis(chloromethyl)- Oxydisulfoton Paraquat Paraquat methosulfate Parathion Parathion-methyl Paris green Pentaborane ... bis(1-methylethyl)amino)ethyl) O-ethyl ester Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester Phosphoric acid, ...
Reductions with metal alkoxyaluminium hydrides
3-bis(chloromethyl)benzo[c] thiophene 2,2-dioxide (0.584 g, 2.2 mmol) in 50 ml of dry benzene was added 0.80 mL (2.8 mmol) of a ... 10)). Ether cleavage is difficult to accomplish with most hydride reagents. However, debenzylation of benzyl aryl ethers may be ... The most common solvents used are tetrahydrofuran and diethyl ether. Whatever solvent is used should be anhydrous and pure. ... In a related application, NaAlH2(OCH2CH2OCH3)2 (sodium bis(methoxyethoxy) aluminium dihydride, SMEAH or Red-Al) reacts with ...
List of chemical warfare agents
Bis(2-chloroethylthio) methane Bis(2-chloroethylthiomethyl) ether Bis(2-chloroethylthioethyl) ether (O Mustard; T) ... Chloromethyl chloroformate Dibenzoxazepine (CR) Ethyl iodoacetate Ortho-chlorobenzylidene malononitrile (Super tear gas; CS) ... Bis(2-chloroethyl)ethylamine (HN1) Bis(2-chloroethyl)methylamine (HN2) Tris(2-chloroethyl)amine (HN3) 1,2-Bis(2-chloroethylthio ... 4-Bis(2-chloroethylthio)-n-butane 1,5-Bis(2-chloroethylthio)-n-pentane 2-Chloroethylchloromethylsulfide Bis(2-chloroethyl) ...
Simmons-Smith reaction
For example, enol ethers like trimethylsilyloxy-substituted olefins are often used because of the high yields obtained. Despite ... Denmark, S. E.; Edwards, J. P. (1991). "A Comparison of (Chloromethyl)- and (Iodomethyl)zinc Cyclopropanation Reagents". J. Org ... Cyclopropan-Bildung aus Olefinen mit Bis-halogenmethyl-zink". Chemische Berichte. 97 (8): 2146-2164. doi:10.1002/cber. ... The modification was proposed in 1968 as a way to turn cationically polymerizable olefins such as vinyl ethers into their ...
Lithium diisopropylamide
Smith, A. P.; Lamba, J. J. S.; Fraser, C. L. (2004). "Efficient Synthesis of Halomethyl-2,2'-Bipyridines: 4,4'-Bis(chloromethyl ... As such it is commercially available as a solution in polar aprotic solvents such as THF and ether; however, for small scale ... Lithium amide Lithium bis(trimethylsilyl)amide (LiHMDS) Lithium tetramethylpiperidide (LiTMP) Evans pKa Table Hamell, Matthew; ...
Quelet reaction
The Quelet reaction (also called the Blanc-Quelet reaction) is an organic coupling reaction in which a phenolic ether reacts ... R. Quelet (1932). "preparation d'un derive chloro-methyl du para-bromo-anisol (methoxy-2 bromo-2 α-chlorotoluene)". Compt. Rend ... Sugawasa, Shigehiko; Fuijsawa, Toshiro; Okada, Kozo (1952). "Synthesis of 2,2-Polymethylene-bis-(Py-tetrahydroisoquinoline) ... The Quelet reaction can produce dangerous halomethyl ethers, gaseous and liquid compounds that are toxic to humans, and ...
Organosilicon compound
Silyl ethers have the connectivity Si-O-C. They are typically prepared by the reaction of alcohols with silyl chlorides: (CH3) ... Commun., 2002, (4), 348-349 doi:10.1039/b109816k Mechanistic insight into copper-catalysed allylic substitutions with bis( ... More specialized derivatives that find commercial applications include dichloromethylphenylsilane, trichloro(chloromethyl) ... are used in deprotection of silyl ethers: (CH3)3Si-O-R + F− + H2O → (CH3)3Si-F + H-O-R + OH− Organosilyl chlorides are ...
NIOSHTIC-2 Search Results - Full View
Worker exposures to benzene (71432), bis-chloromethyl-ether (542881), 2,6-ditert-butyl-p-cresol (128370), carbon-monoxide ( ... Bis-Chloromethyl Ether; 2,6-Ditert-Butyl-P-Cresol; BHT; Carbon Monoxide; Formaldehyde; Hydrogen Chloride; Hydrogen Cyanide; ...
NIOSHTIC-2 Search Results - Basic View
Hazard review of bis(chloromethyl)ether (BCME). Authors. Lassiter DV Source. NIOSH 1973 Jun; :1-14 ...
NIOSHTIC-2 Search Results - Full View
Bis-chloromethyl-ether was not detected in any samples. The authors conclude that noise levels were below average, and ...
Occupational Health Guidelines for Chemical Hazards (81-123) | NIOSH | CDC
bis-Chloromethyl ether. 542-88-1. 0128.pdf pdf icon. No Revision. ... Isopropyl ether. 108-20-3. 0362.pdf pdf icon. No Revision. Isopropyl glycidyl ether. 4016-14-2. 0363.pdf pdf icon. No Revision ... Chloromethyl methyl ether. 107-30-2. 0129.pdf pdf icon. No Revision. ... Dichloroethyl ether. 111-44-4. 0196.pdf pdf icon. No Revision. Dichloromonofluoromethane. 75-43-4. 0197.pdf pdf icon. No ...
NIOSHTIC-2 Search Results - Full View
... bis- chloromethyl-ether (107302), chromium (7440473), beryllium (7440417), and cadmium (7440439). Major findings and ...
Results of search for 'ccl=copydate:'1998).''
›
WHO HQ Library catalog
Bis(Chloromethyl) et... * Dose-response relati... * Environmental exposu... * Methacrylates * Occupational exposur... * Show ... Selected chloroalkyl ethers. by Liteplo, R , Gomes, R , World Health Organization , International Programme on Chemical Safety. ...
NIOSHTIC-2 Search Results - Basic View
Hazard review of bis(chloromethyl)ether (BCME). Authors. Lassiter DV Source. NIOSH 1973 Jun; :1-14 ...
NIOSHTIC-2 Search Results - Full View
No exposure hazards were found for bis-chloromethyl-ether (542881), formaldehyde (50000), hydrochloric-acid (7647010), sulfur- ... Bis-Chloromethyl Ether; Calcium Oxide; Hexavalent Chromium; Nickel; Ultraviolet Radiation ...
Bis(chloromethyl) Ether | ToxFAQs™ | ATSDR
Bis(chloromethyl) ether is highly irritating to the skin, eyes, nose, throat, and lungs and it is a carcinogen. Bis( ... chloromethyl) ether is only used in small amounts inside fully enclosed systems to make other chemicals. Use of this chemical ... chloromethyl) ether has been found at 2 of the 1,518 National Priorities List sites identified by the Environmental Protection ... ether?. There are no specific tests to show if you have been exposed to bis(chloromethyl) ether. Bis(chloromethyl) ether breaks ...
Bis(chloromethyl)ether (2005-110) | NIOSH | CDC
Bis(chloromethyl) ether - Wikipedia
Bis(chloromethyl) ether was no exception to this with production in the U.S.A. ending in 1982. Bis(chloromethyl) ether has been ... It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. Bis(chloromethyl) ether ... Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. "#0128". ... Chloromethylation of benzene and alkylbenzenes with bis(chloromethyl)ether, 1,4-bis(chloromethoxy)butane, 1-chloro-4- ...
Browsing by Subject "Bis(Chloromethyl) Ether"
Substance Priority List | ATSDR
NIOSHTIC-2 Search Results - Full View
MeSH Browser
Bis(Chloromethyl)Ether Chloromethyl Ether Dichloromethyl Ether Registry Number. 77382IHE37. Related Numbers. 542-88-1. CAS Type ... use BIS(CHLOROMETHYL) ETHER to search DICHLOROMETHYL ETHER 1975-78. History Note. 91(79); was see under METHYL ETHERS 1979-90; ... Bis(Chloromethyl) Ether Preferred Term Term UI T005031. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bis(Chloromethyl) Ether Preferred Concept UI. M0002605. Registry Number. 77382IHE37. Related Numbers. 542-88-1. Scope Note. A ...
NIOSHTIC-2 Search Results - Full View
Rule 3745-114-01 - Ohio Administrative Code | Ohio Laws
Periodic Table of Elements: Common Compounds of Hydrogen - H (EnvironmentalChemistry.com)
bis(2-(Dimethylamino)ethyl)ether. Formula: C8H20N2O [(CH3)2NCH2CH2OCH2CH2N(CH3)2]. *bis-Chloromethyl ether. Formula: (CH2Cl)2O ... Chloromethyl methyl ether. Formula: CH3OCH2Cl. *Chloroprene. Formula: CH2=CClCH=CH2. *Chlorpyrifos. Formula: C9H11Cl3NO3PS. * ... Phenyl ether (vapor). Formula: C6H5OC6H5. *Phenyl ether-biphenyl mixture (vapor). Formula: C6H5OC6H5/C6H5C6H5. *Phenyl glycidyl ... Isopropyl ether. Formula: (CH3)2CHOCH(CH3)2. *Isopropyl glycidyl ether. Formula: C6H12O2. *Isopropylamine. Formula: (CH3)2CHNH2 ...
Proposition 65 List of Elabscience Chemicals
Bis(chloromethyl)ether - 542-88-1 - Toxicity: cancer. *Bis(2-chloro-1-methylethyl)ether, technical grade - Toxicity: cancer ... Bis(2-chloroethyl)ether - 111-44-4 - Toxicity: cancer. *N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) - 494-03-1 - ... Chloromethyl methyl ether (technical grade) - 107-30-2 - Toxicity: cancer. *3-Chloro-2-methylpropene - 563-47-3 - Toxicity: ... 4,4-Methylene bis(2-chloroaniline) - 101-14-4 - Toxicity: cancer. *4,4-Methylene bis(N,N-dimethyl)benzenamine - 101-61-1 - ...
The complete chemical list for the Clean Air Act 112r rules - free
Bis(chloromethyl) ether 542-88-1 1,000. Borane, trichloro- 10294-34-5 5,000. Borane, trifluoro- 7637-07-2 5,000. Boron ... Chloromethyl ether 542-88-1 1,000. Chloromethyl methyl ether 107-30-2 5,000. Crotonaldehyde 4170-30-3 20,000. Crotonaldehyde, ( ... Vinyl ethyl ether 109-92-2 10,000. Vinyl fluoride 75-02-5 10,000. Vinyl methyl ether 107-25-5 10,000. Vinylidene chloride 75-35 ... Ethyl ether 60-29-7 10,000. Ethyl mercaptan 75-08-1 10,000. Ethyl nitrite 109-95-5 10,000. Ethylene 74-85-1 10,000. Ethylene ...
Irritant Gas Inhalation Injury - Pulmonary Disorders - Merck Manuals Professional Edition
Registration Dossier - ECHA
Registration Dossier - ECHA
SYNTHETIC ORG. CHEM. MFRS | 506 F.2d 385 (1974) | 6f2d3851846 | Leagle.com
... the substance was contaminated to form bis chloromethyl ether (BCME).. 2. Again, the issue is the same as that in the EI appeal ... The thrust of the opposition to the standard regulating chloromethyl methyl ether (CMME) is aimed at certain studies relied ... In summary then, the regulations applicable to 4,4 methylene bis (2-chloroaniline) (MOCA) will be remanded for the publication ... Polyurethane Manufacturers Association (PMA), the employers association concerned with the use of 4,4 methylene bis (2- ...
CDC/NIH Web Information Database|Home|PHGKB
Chemically-Induced Cancer
Code System Concept
Toxicological Profiles | ATSDR
Dangerous chemicals in the lab
Medical Abbreviations - B - New Medical Terms [2022]
Section 7412 - Hazardous air pollutants, 42 U.S.C. § 7412 | Casetext Search + Citator
Bis(2-ethylhexyl)phthalate (DEHP). 542881. Bis(chloromethyl)ether. 75252. Bromoform. 106990. 1,3-Butadiene. ... R = R, H, or groups which, when removed, yield glycol ethers with the structure: R-(OCH2CH)n-OH. Polymers are excluded from ... 2 Includes mono- and di- ethers of ethylene glycol, diethylene glycol, and triethylene glycol R-(OCH2CH2)n-OR where ... NOTE: For all listings above which contain the word "compounds" and for glycol ethers, the following applies: Unless otherwise ...
WHO | The k2p blog
English-Armenian Medical - Terms starting with 'I' - MEDINDEX.AM
Toxicological Profiles | ATSDR
Difference between revisions of "Medical Surveillance" - University of Nebraska Medical Center
Canada Gazette, Part 1, Volume 156, Number 20: Prohibition of Certain Toxic Substances Regulations, 2022
... and adding bis(chloromethyl) ether (BCME) and chloromethyl methyl ether (CMME). Over the years, the Regulations have been ... Bis(chloromethyl) ether, which has the molecular formula C2H4Cl2O. ... Chloromethyl methyl ether, which has the molecular formula C2H5ClO. ... Conditions - decabromodiphenyl ether. 8 (1) If the toxic substance is decabromodiphenyl ether referred to in item 15, column 1 ...
Ethyl1
- The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. (rapp-polymere.com)
BCME2
- The employers contest the validity of the Van Duuren studies 1 by questioning whether pure CMME was tested or whether, as usually occurs, the substance was contaminated to form bis chloromethyl ether (BCME). (leagle.com)
- Mixingwith formaldehyde results in the evolution of chlorine gas, fomic acid, hydrochloric acid fumes , chlorine oxidesand possibly other hazardous by-products of chemical interaction, such as BCME (bis-chloromethyl ether), avery dangerous, neurotoxic gas. (magicsnewbiewines.com)
Chloroalkyl ethers1
- It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. (wikipedia.org)
MENTHYL ETHER1
- Chloromethyl menthyl ether, 95%, 97% e.e. (agricheme.com)
Carcinogenic4
- The International Agency for Research on Cancer (IARC) has concluded that bis(chloromethyl) ether is carcinogenic to humans. (cdc.gov)
- Bis(chloromethyl) ether was once produced on a large scale, but was found to be highly carcinogenic and thus such production has ceased. (wikipedia.org)
- Because of their carcinogenic potency, the industrial production of chloromethyl ethers ended in most countries in the early 1980s. (wikipedia.org)
- Bis(chloromethyl) ether is carcinogenic. (wikipedia.org)
Oxirane1
- 2-Propenoic acid, polymers with bisphenol A diglycidyl ether and oxirane mono[(C10-16-alkyloxy)methyl] derivs. (ckspharm.com)
Acid2
- It is also produced as a byproduct in the Blanc chloromethylation reaction, formed when formaldehyde (the monomer, paraformaldehyde or formalin) and concentrated hydrochloric acid are mixed, and is a known impurity in technical grade chloromethyl methyl ether. (wikipedia.org)
- And don't buffer formaldehyde with hydrochloric acid, because together they form a potent carcinogen, bis-chloromethyl ether. (bitesizebio.com)
Glycol1
- 4241. 1 Dipentyl ether 190 Ethylene glycol dibutyl ether 203. (qrforex.com)
Carcinogen3
- The U.S. Department of Health and Human Services (DHHS) has classified bis(chloromethyl) ether as a known human carcinogen (causing cancer in people). (cdc.gov)
- The U.S. Environmental Protection Agency (EPA) has determined that bis(chloromethyl) ether is a known human carcinogen. (cdc.gov)
- The Department of Health and Human Services (DHHS) has determined that bis (chloromethyl) ether is a known human carcinogen. (cancereffects.com)
Chloroethyl1
- Chloromethyl methyl ether - CH2ClOMe Bis(chloroethyl) ether - (CH2ClCH2)2O NIOSH Pocket Guide to Chemical Hazards. (wikipedia.org)
Lung cancer3
- Studies have shown breathing bis(chloromethyl) ether during work causes lung cancer in some people. (cdc.gov)
- Among these are lung cancer in uranium miners, sarcoma of the jaw in radium dial painters, bladder cancer in workers exposed to aromatic amines, angiosarcoma of the liver in vinyl chloride workers, lung cancer in workers exposed to bis-chloromethyl ether used in plexiglass manufacture, mesothelioma and lung cancer in workers exposed to asbestos, and leukemia and other hematopoietic cancers in benzene-exposed workers. (toxictorts.com)
- Chloromethyl ether - studies has shown thatbis(chloromethyl) ether can cause lung cancer and other malignant tumors in people and animals. (cancereffects.com)
Methylene1
- Polyurethane Manufacturers Association (PMA), the employers' association concerned with the use of 4,4' methylene bis (2-chloroaniline) (MOCA) 3 in various manufacturing processes, presses the same arguments as to carcinogenicity that are advanced for DCB and CMME. (leagle.com)
Quantities1
- The small quantities of bis(chloromethyl) ether that are produced in the United States are only used in enclosed systems to make other chemicals. (cdc.gov)
Polymers1
- In the past, Bis(chloromethyl) ether was used to make several types of polymers, resins, and textiles, but these uses have stopped. (cdc.gov)
Ethene1
- For example, bis(triethoxysilyl)ethene ( BTES-E2 )- and bis(triethoxysilyl)ethyne ( BTES-E3 )-derived membranes were found to exhibit increased water permeance compared with bis(triethoxysilyl)ethane ( BTES-E1 )-derived membranes. (nature.com)
Chemicals2
- VIO Chemicals offers a broad range of Intermediates for API synthesis, including 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine HCl for the synthesis of Lansoprazole and Dexlansprazole APIs. (cphi-online.com)
- Arch Chemicals, Inc. submitted revisions/updates to the robust summaries and test plans for Hydroquinone bis(2-hydroxyethyl) Ether . (webharvest.gov)
NIOSH1
- Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). (lookchem.com)
Derivative1
- The first reaction is O-alkylation of p-cresol to give a 4-methylphenyl allyl ether derivative 3. (stackexchange.com)
Exposure1
- Additional risk factors include exposure to asbestos, radon, uranium mining, and bis-chloromethyl ether. (dermatologyadvisor.com)
Alcohol1
- It is a clear liquid with various grades having different boiling points, that is insoluble in water and soluble in alcohol and ether,and used in aviation gasoline, coatings, lacquers, rubber cements, organic synthesis, and polyester resin manufacture. (chemicalbook.com)
Studies1
- The thrust of the opposition to the standard regulating chloromethyl methyl ether (CMME) is aimed at certain studies relied upon by the Secretary. (leagle.com)
Workers1
- Workers exposed to air containing bis(chloromethyl) ether had coughing, bronchitis, and difficulty breathing. (cdc.gov)
Form1
- 1,3-bis(2-methylphenyl)guanidine: form recommended by the IUPAC (International Union of Pure and Applied Chemistry). (gc.ca)
Synthesis1
- Bis(chloromethyl) ether has been extensively used in chemical synthesis, primarily as a crosslinking agent in the manufacture of ion-exchange resins and in the textile industry. (wikipedia.org)
People1
- Most people are very unlikely to come into contact with bis(chloromethyl) ether. (cdc.gov)
Animals3
- Bis(chloromethyl) ether does not accumulate (build up) in plants or animals. (cdc.gov)
- In animals, breathing bis(chloromethyl) ether caused breathing problems and lung damage. (cdc.gov)
- Nose and lung cancers were also seen in animals after they breathed bis(chloromethyl) ether for short or long periods of time. (cdc.gov)
Medical test1
- Can I get a medical test to check for bis(chloromethyl) ether? (cdc.gov)
Standard1
- The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. (lookchem.com)
Profile1
- 2017. Toxicological Profile for Bis(chloromethyl) ether . (cdc.gov)
Water3
- Bis(chloromethyl) ether dissolves easily in water. (cdc.gov)
- In water, bis(chloromethyl) ether dissolves and is very quickly broken-down. (cdc.gov)
- Pencil hardness tests and water contact angle measurements of the BTES-MAz film surface were performed to show that the surface of this film was softer and more hydrophobic than that of film prepared from bis(triethoxysilyl)ethane ( BTES-E1 ). (nature.com)
Production1
- Bis(chloromethyl) ether was no exception to this with production in the U.S.A. ending in 1982. (wikipedia.org)