A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Agents that are used to treat bipolar disorders or mania associated with other affective disorders.
Inorganic compounds that contain lithium as an integral part of the molecule.
Those disorders that have a disturbance in mood as their predominant feature.
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
Persistent and disabling ANXIETY.
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
The feeling-tone accompaniment of an idea or mental representation. It is the most direct psychic derivative of instinct and the psychic representative of the various bodily changes by means of which instincts manifest themselves.
Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.
An affective disorder characterized by periods of depression and hypomania. These may be separated by periods of normal mood.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Disorders related to substance abuse.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The unsuccessful attempt to kill oneself.
A salt of lithium that has been used experimentally as an immunomodulator.
The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.
One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.
Physiological changes that occur in bodies after death.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.
An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
A directed conversation aimed at eliciting information for psychiatric diagnosis, evaluation, treatment planning, etc. The interview may be conducted by a social worker or psychologist.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)
Study of mental processes and behavior of schizophrenics.
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
A repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate societal norms or rules are violated. These behaviors include aggressive conduct that causes or threatens physical harm to other people or animals, nonaggressive conduct that causes property loss or damage, deceitfulness or theft, and serious violations of rules. The onset is before age 18. (From DSM-IV, 1994)
Child with one or more parents afflicted by a physical or mental disorder.
The determination and evaluation of personality attributes by interviews, observations, tests, or scales. Articles concerning personality measurement are considered to be within scope of this term.
Frequency and quality of negative emotions, e.g., anger or hostility, expressed by family members or significant others, that often lead to a high relapse rate, especially in schizophrenic patients. (APA, Thesaurus of Psychological Index Terms, 7th ed)
Those affective states which can be experienced and have arousing and motivational properties.
An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.
The ability to generate new ideas or images.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.
A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.
Includes two similar disorders: oppositional defiant disorder and CONDUCT DISORDERS. Symptoms occurring in children with these disorders include: defiance of authority figures, angry outbursts, and other antisocial behaviors.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.
Facilities which administer the delivery of psychologic and psychiatric services to people living in a neighborhood or community.
Methods for visualizing REGIONAL BLOOD FLOW, metabolic, electrical, or other physiological activities in the CENTRAL NERVOUS SYSTEM using various imaging modalities.
Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in individuals 13-18 years.
Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.
A form of group psychotherapy. It involves treatment of more than one member of the family simultaneously in the same session.
The act of killing oneself.
Observable changes of expression in the face in response to emotional stimuli.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Drugs used to prevent SEIZURES or reduce their severity.
Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in children.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Mood or emotional responses dissonant with or inappropriate to the behavior and/or stimulus.
An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)
Strong desires to accomplish something. This usually pertains to greater values or high ideals.
A social group consisting of parents or parent substitutes and children.
A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)).
A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.
The return of a sign, symptom, or disease after a remission.
Intellectual or mental process whereby an organism obtains knowledge.
Assessment of psychological variables by the application of mathematical procedures.
Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.
The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.
Behaviors which are at variance with the expected social norm and which affect other individuals.
A set of cognitive functions that controls complex, goal-directed thought and behavior. Executive function involves multiple domains, such as CONCEPT FORMATION, goal management, cognitive flexibility, INHIBITION control, and WORKING MEMORY. Impaired executive function is seen in a range of disorders, e.g., SCHIZOPHRENIA; and ADHD.
A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
Electrically induced CONVULSIONS primarily used in the treatment of severe AFFECTIVE DISORDERS and SCHIZOPHRENIA.
Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.
A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.
Disorders related to or resulting from abuse or mis-use of alcohol.
Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.
Dominance of one cerebral hemisphere over the other in cerebral functions.
Aid for consistent recording of data such as tasks completed and observations noted.
Action taken to reduce susceptibility or exposure to health problems and to detect and treat disease in early stages.
The study of significant causes and processes in the development of mental illness.
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
Statistical interpretation and description of a population with reference to distribution, composition, or structure.
Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
The ability of the BRAIN to suppress neuronal responses to external sensory inputs, such as auditory and visual stimuli. Sensory filtering (or gating) allows humans to block out irrelevant, meaningless, or redundant stimuli.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
A subfield of psychiatry that emphasizes the somatic substructure on which mental operations and emotions are based, and the functional or organic disturbances of the central nervous system that give rise to, contribute to, or are associated with mental and emotional disorders. (From Campbell's Psychiatric Dictionary, 8th ed.)
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Neural tracts connecting one part of the nervous system with another.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Elements of limited time intervals, contributing to particular results or situations.
A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)
Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.
Disruptions of the rhythmic cycle of bodily functions or activities.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.

The social and economic effects of manic depressive illness and of its treatment in lithium clinics. (1/2554)

Advising about the employment of those who have had manic depressive episodes requires Occupational Health Physicians to obtain, with consent, an objective account of previous episodes and to appreciate the enormous range of manic and depressive manifestations. Familiarity is needed with the likely effects of treatment of episodes and the benefits and problems of prophylaxis--not just in general but in individual cases, for example, where driving is required. This article summarizes research into the effects of lithium preparations on the course of the illness, thyroid and renal function and the risk of suicide. The author found that changing from treatment of episodes to continuous prophylaxis benefited employment and personal relationships without causing body weight problems. Many patients do well in life if supported by an experienced professional team, with 61% requiring no further admissions once on lithium, and with an 86% reduction in admissions achieved in our local clinic.  (+info)

Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial. (2/2554)

Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT1A autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores < 8) at the end of treatment was 15/20 for pindolol, and 3/20 for placebo. Coadministration of pindolol and TSD resulted in a complete response, which could be sustained for six months with lithium salts alone, in 65% of cases. This results suggest a major role for serotonergic transmission in the mechanism of action of TSD, and makes TSD treatment more effective in the treatment of bipolar depression.  (+info)

A note on power approximations for the transmission/disequilibrium test. (3/2554)

The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.  (+info)

Acute barium intoxication following ingestion of ceramic glaze. (4/2554)

A case of deliberate overdose of barium sulphide in a psychiatric setting is presented, with resulting flaccid paralysis, malignant arrhythmia, respiratory arrest and severe hypokalaemia, but ultimately with complete recovery. The degree of paralysis appears to be related directly to serum barium levels. The value of early haemodialysis, particularly with respiratory paralysis and hypokalaemia, is emphasised.  (+info)

Pharmacogenetics of lithium response in bipolar disorder. (5/2554)

Lithium is the first-line treatment for bipolar disorder. In the past, genetic studies have attempted to identify factors associated with positive treatment response or side effects. Several research groups have shown that familial factors, family history of primary bipolar disorder, and negative family history of schizophrenia in particular, correlate well with prophylactic lithium response. Conversely, studies of lithium responsive patients and their families can assist genetic research of bipolar disorder. Lithium responders appear to suffer from a form of bipolar disorder that is more genetically based and more homogeneous. In a series of family studies, the author and his colleagues have confirmed the differences in family histories of lithium responders and nonresponders and shown that the mode of inheritance in lithium responders is compatible with a major-gene model. Subsequently, they initiated an international collaborative study to map the gene(s) predisposing to the illness or treatment response, or both, using both linkage and association strategies. To date, a sample of 32 families, 138 unrelated patients and 163 control subjects has been studied. In these studies, they found support for the role of phospholipase C in lithium responsive bipolar disorder.  (+info)

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. (6/2554)

Bipolar disorder is a severe mental illness characterized by mood swings of elation and depression. Family, twin, and adoption studies suggest a complex genetic etiology that may involve multiple susceptibility genes and an environmental component. To identify chromosomal loci contributing to vulnerability, we have conducted a genome-wide scan on approximately 396 individuals from 22 multiplex pedigrees by using 607 microsatellite markers. Multipoint nonparametric analysis detected the strongest evidence for linkage at 13q32 with a maximal logarithm of odds (lod) score of 3.5 (P = 0. 000028) under a phenotype model that included bipolar I, bipolar II with major depression, schizoaffective disorder, and recurrent unipolar disorder. Suggestive linkage was found on 1q31-q32 (lod = 2. 67; P = 0.00022) and 18p11.2 (lod = 2.32; P = 0.00054). Recent reports have linked schizophrenia to 13q32 and 18p11.2. Our genome scan identified other interesting regions, 7q31 (lod = 2.08; P = 0. 00099) and 22q11-q13 (lod = 2.1; P = 0.00094), and also confirmed reported linkages on 4p16, 12q23-q24, and 21q22. By comprehensive screening of the entire genome, we detected unreported loci for bipolar disorder, found support for proposed linkages, and gained evidence for the overlap of susceptibility regions for bipolar disorder and schizophrenia.  (+info)

Plasma catecholamine metabolites as markers for psychosis and antipsychotic response in schizophrenia. (7/2554)

The objective of this study was to determine the association between the patterns of change in the dopaminergic metabolite plasma homovanillic acid (HVA), the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), and psychosis following haloperidol withdrawal in schizophrenic patients. Weekly plasma measurements were obtained in 107 subjects with schizophrenia or schizoaffective disorder. Random regression was used to control for individual variance while modeling metabolite changes over time and relationships with psychosis. Changes in plasma MHPG were not significantly associated with relapse or psychosis, while increased plasma HVA was found to be associated with relapse. Psychosis was correlated negatively with plasma HVA levels. The current analysis, controlling for individual variance, indicates that there is evidence for pharmacological effects on plasma HVA, but not plasma MHPG. In addition, these metabolites do not appear to be direct markers of psychosis, but may be associated with a compensatory response by the system to return to the steady state.  (+info)

Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18. (8/2554)

Linkage disequilibrium (LD) analysis has been promoted as a method of mapping disease genes, particularly in isolated populations, but has not yet been used for genome-screening studies of complex disorders. We present results of a study to investigate the feasibility of LD methods for genome screening using a sample of individuals affected with severe bipolar mood disorder (BP-I), from an isolated population of the Costa Rican central valley. Forty-eight patients with BP-I were genotyped for markers spaced at approximately 6-cM intervals across chromosome 18. Chromosome 18 was chosen because a previous genome-screening linkage study of two Costa Rican families had suggested a BP-I locus on this chromosome. Results of the current study suggest that LD methods will be useful for mapping BP-I in a larger sample. The results also support previously reported possible localizations (obtained from a separate collection of patients) of BP-I-susceptibility genes at two distinct sites on this chromosome. Current limitations of LD screening for identifying loci for complex traits are discussed, and recommendations are made for future research with these methods.  (+info)

Bipolar Disorder Types:

There are several types of bipolar disorder, including:

1. Bipolar I Disorder: One or more manic episodes with or without depressive episodes.
2. Bipolar II Disorder: At least one major depressive episode and one hypomanic episode (a less severe form of mania).
3. Cyclothymic Disorder: Periods of hypomania and depression that last at least 2 years.
4. Other Specified Bipolar and Related Disorders: Symptoms that do not meet the criteria for any of the above types.
5. Unspecified Bipolar and Related Disorders: Symptoms that do not meet the criteria for any of the above types, but there is still a noticeable impact on daily life.

Bipolar Disorder Causes:

The exact cause of bipolar disorder is unknown, but it is believed to involve a combination of genetic, environmental, and neurobiological factors. Some potential causes include:

1. Genetics: Individuals with a family history of bipolar disorder are more likely to develop the condition.
2. Brain structure and function: Imbalances in neurotransmitters and abnormalities in brain structure have been found in individuals with bipolar disorder.
3. Hormonal imbalances: Imbalances in hormones such as serotonin, dopamine, and cortisol have been linked to bipolar disorder.
4. Life events: Traumatic events or significant changes in life circumstances can trigger episodes of mania or depression.
5. Medical conditions: Certain medical conditions, such as multiple sclerosis or stroke, can increase the risk of developing bipolar disorder.

Bipolar Disorder Symptoms:

The symptoms of bipolar disorder can vary depending on the individual and the specific type of episode they are experiencing. Some common symptoms include:

1. Manic episodes: Increased energy, reduced need for sleep, impulsivity, and grandiosity.
2. Depressive episodes: Feelings of sadness, hopelessness, and loss of interest in activities.
3. Mixed episodes: A combination of manic and depressive symptoms.
4. Hypomanic episodes: Less severe than full-blown mania, but still disrupt daily life.
5. Rapid cycling: Experiencing four or more episodes within a year.
6. Melancholic features: Feeling sad, hopeless, and worthless.
7. Atypical features: Experiencing mania without elevated mood or grandiosity.
8. Mood instability: Rapid changes in mood throughout the day.
9. Anxiety symptoms: Restlessness, feeling on edge, and difficulty concentrating.
10. Sleep disturbances: Difficulty falling or staying asleep, or oversleeping.
11. Substance abuse: Using drugs or alcohol to cope with symptoms.
12. Suicidal thoughts or behaviors: Having thoughts of harming oneself or taking actions that could lead to death.

It's important to note that not everyone with bipolar disorder will experience all of these symptoms, and some people may experience additional symptoms not listed here. Additionally, the severity and frequency of symptoms can vary widely between individuals.

There are several types of mood disorders, including:

1. Major Depressive Disorder (MDD): This is a condition characterized by persistent feelings of sadness, hopelessness, and a loss of interest in activities that were once enjoyed. It can also involve changes in appetite, sleep patterns, and energy levels.
2. Bipolar Disorder: This is a condition that involves periods of mania or hypomania (elevated mood) alternating with episodes of depression.
3. Persistent Depressive Disorder (PDD): This is a condition characterized by persistent low mood, lasting for two years or more. It can also involve changes in appetite, sleep patterns, and energy levels.
4. Postpartum Depression (PPD): This is a condition that occurs in some women after childbirth, characterized by feelings of sadness, anxiety, and a lack of interest in activities.
5. Seasonal Affective Disorder (SAD): This is a condition that occurs during the winter months, when there is less sunlight. It is characterized by feelings of sadness, lethargy, and a lack of energy.
6. Anxious Distress: This is a condition characterized by excessive worry, fear, and anxiety that interferes with daily life.
7. Adjustment Disorder: This is a condition that occurs when an individual experiences a significant change or stressor in their life, such as the loss of a loved one or a job change. It is characterized by feelings of sadness, anxiety, and a lack of interest in activities.
8. Premenstrual Dysphoric Disorder (PMDD): This is a condition that occurs in some women during the premenstrual phase of their menstrual cycle, characterized by feelings of sadness, anxiety, and a lack of energy.

Mood disorders can be treated with a combination of medication and therapy. Antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are commonly used to treat mood disorders. These medications can help relieve symptoms of depression and anxiety by altering the levels of neurotransmitters in the brain.

Therapy, such as cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT), can also be effective in treating mood disorders. CBT helps individuals identify and change negative thought patterns and behaviors that contribute to their depression, while IPT focuses on improving communication skills and relationships with others.

In addition to medication and therapy, lifestyle changes such as regular exercise, healthy eating, and getting enough sleep can also be helpful in managing mood disorders. Support from family and friends, as well as self-care activities such as meditation and relaxation techniques, can also be beneficial.

It is important to seek professional help if symptoms of depression or anxiety persist or worsen over time. With appropriate treatment, individuals with mood disorders can experience significant improvement in their symptoms and overall quality of life.

The term "schizophrenia" was first used by the Swiss psychiatrist Eugen Bleuler in 1908 to describe the splitting of mental functions, which he believed was a key feature of the disorder. The word is derived from the Greek words "schizein," meaning "to split," and "phrenos," meaning "mind."

There are several subtypes of schizophrenia, including:

1. Paranoid Schizophrenia: Characterized by delusions of persecution and suspicion, and a tendency to be hostile and defensive.
2. Hallucinatory Schizophrenia: Characterized by hearing voices or seeing things that are not there.
3. Disorganized Schizophrenia: Characterized by disorganized thinking and behavior, and a lack of motivation or interest in activities.
4. Catatonic Schizophrenia: Characterized by immobility, mutism, and other unusual movements or postures.
5. Undifferentiated Schizophrenia: Characterized by a combination of symptoms from the above subtypes.

The exact cause of schizophrenia is still not fully understood, but it is believed to involve a combination of genetic, environmental, and neurochemical factors. It is important to note that schizophrenia is not caused by poor parenting or a person's upbringing.

There are several risk factors for developing schizophrenia, including:

1. Genetics: A person with a family history of schizophrenia is more likely to develop the disorder.
2. Brain chemistry: Imbalances in neurotransmitters such as dopamine and serotonin have been linked to schizophrenia.
3. Prenatal factors: Factors such as maternal malnutrition or exposure to certain viruses during pregnancy may increase the risk of schizophrenia in offspring.
4. Childhood trauma: Traumatic events during childhood, such as abuse or neglect, have been linked to an increased risk of developing schizophrenia.
5. Substance use: Substance use has been linked to an increased risk of developing schizophrenia, particularly cannabis and other psychotic substances.

There is no cure for schizophrenia, but treatment can help manage symptoms and improve quality of life. Treatment options include:

1. Medications: Antipsychotic medications are the primary treatment for schizophrenia. They can help reduce positive symptoms such as hallucinations and delusions, and negative symptoms such as a lack of motivation or interest in activities.
2. Therapy: Cognitive-behavioral therapy (CBT) and other forms of talk therapy can help individuals with schizophrenia manage their symptoms and improve their quality of life.
3. Social support: Support from family, friends, and support groups can be an important part of the treatment plan for individuals with schizophrenia.
4. Self-care: Engaging in activities that bring pleasure and fulfillment, such as hobbies or exercise, can help individuals with schizophrenia improve their overall well-being.

It is important to note that schizophrenia is a complex condition, and treatment should be tailored to the individual's specific needs and circumstances. With appropriate treatment and support, many people with schizophrenia are able to lead fulfilling lives and achieve their goals.

Some common types of mental disorders include:

1. Anxiety disorders: These conditions cause excessive worry, fear, or anxiety that interferes with daily life. Examples include generalized anxiety disorder, panic disorder, and social anxiety disorder.
2. Mood disorders: These conditions affect a person's mood, causing feelings of sadness, hopelessness, or anger that persist for weeks or months. Examples include depression, bipolar disorder, and seasonal affective disorder.
3. Personality disorders: These conditions involve patterns of thought and behavior that deviate from the norm of the average person. Examples include borderline personality disorder, narcissistic personality disorder, and antisocial personality disorder.
4. Psychotic disorders: These conditions cause a person to lose touch with reality, resulting in delusions, hallucinations, or disorganized thinking. Examples include schizophrenia, schizoaffective disorder, and brief psychotic disorder.
5. Trauma and stressor-related disorders: These conditions develop after a person experiences a traumatic event, such as post-traumatic stress disorder (PTSD).
6. Dissociative disorders: These conditions involve a disconnection or separation from one's body, thoughts, or emotions. Examples include dissociative identity disorder (formerly known as multiple personality disorder) and depersonalization disorder.
7. Neurodevelopmental disorders: These conditions affect the development of the brain and nervous system, leading to symptoms such as difficulty with social interaction, communication, and repetitive behaviors. Examples include autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), and Rett syndrome.

Mental disorders can be diagnosed by a mental health professional using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which provides criteria for each condition. Treatment typically involves a combination of medication and therapy, such as cognitive-behavioral therapy or psychodynamic therapy, depending on the specific disorder and individual needs.

Some common types of anxiety disorders include:

1. Generalized Anxiety Disorder (GAD): Excessive and persistent worry about everyday things, even when there is no apparent reason to be concerned.
2. Panic Disorder: Recurring panic attacks, which are sudden feelings of intense fear or anxiety that can occur at any time, even when there is no obvious trigger.
3. Social Anxiety Disorder (SAD): Excessive and persistent fear of social or performance situations in which the individual is exposed to possible scrutiny by others.
4. Specific Phobias: Persistent and excessive fear of a specific object, situation, or activity that is out of proportion to the actual danger posed.
5. Obsessive-Compulsive Disorder (OCD): Recurring, intrusive thoughts (obsessions) and repetitive behaviors (compulsions) that are distressing and disruptive to daily life.
6. Post-Traumatic Stress Disorder (PTSD): Persistent symptoms of anxiety, fear, and avoidance after experiencing a traumatic event.

Anxiety disorders can be treated with a combination of psychotherapy, medication, or both, depending on the specific diagnosis and severity of symptoms. With appropriate treatment, many people with anxiety disorders are able to manage their symptoms and improve their quality of life.

The exact cause of MDD is not known, but it is believed to involve a combination of genetic, environmental, and psychological factors. Some risk factors for developing MDD include:

* Family history of depression or other mental health conditions
* History of trauma or stressful life events
* Chronic illness or chronic pain
* Substance abuse or addiction
* Personality traits such as low self-esteem or perfectionism

Symptoms of MDD can vary from person to person, but typically include:

* Persistent feelings of sadness, emptiness, or hopelessness
* Loss of interest in activities that were once enjoyed
* Changes in appetite or sleep patterns
* Fatigue or loss of energy
* Difficulty concentrating or making decisions
* Thoughts of death or suicide

MDD can be diagnosed by a mental health professional, such as a psychiatrist or psychologist, based on the symptoms and their duration. Treatment typically involves a combination of medication and therapy, and may include:

* Antidepressant medications to relieve symptoms of depression
* Psychotherapy, such as cognitive-behavioral therapy (CBT), to help identify and change negative thought patterns and behaviors
* Interpersonal therapy (IPT) to improve communication skills and relationships with others
* Other forms of therapy, such as mindfulness-based therapies or relaxation techniques

It is important to seek professional help if symptoms of depression are severe or persistent, as MDD can have a significant impact on daily life and can increase the risk of suicide. With appropriate treatment, however, many people with MDD are able to manage their symptoms and improve their quality of life.

Some common types of psychotic disorders include:

1. Schizophrenia: A chronic and severe mental disorder that affects how a person thinks, feels, and behaves. It can cause hallucinations, delusions, and disorganized thinking.
2. Bipolar Disorder: A mood disorder that causes extreme changes in mood, energy, and behavior. It can lead to manic or hypomanic episodes, as well as depression.
3. Schizoaffective Disorder: A mental disorder that combines symptoms of schizophrenia and a mood disorder. It can cause hallucinations, delusions, and mood swings.
4. Brief Psychotic Disorder: A short-term episode of psychosis that can be triggered by a stressful event. It can cause hallucinations, delusions, and a break from reality.
5. Postpartum Psychosis: A rare condition that occurs in some new mothers after childbirth. It can cause hallucinations, delusions, and a break from reality.
6. Drug-Induced Psychosis: A psychotic episode caused by taking certain medications or drugs. It can cause hallucinations, delusions, and a break from reality.
7. Alcohol-Related Psychosis: A psychotic episode caused by alcohol use disorder. It can cause hallucinations, delusions, and a break from reality.
8. Trauma-Related Psychosis: A psychotic episode caused by a traumatic event. It can cause hallucinations, delusions, and a break from reality.
9. Psychotic Disorder Not Otherwise Specified (NOS): A catch-all diagnosis for psychotic episodes that do not meet the criteria for any other specific psychotic disorder.

Symptoms of psychotic disorders can vary depending on the individual and the specific disorder. Common symptoms include:

1. Hallucinations: Seeing, hearing, or feeling things that are not there.
2. Delusions: False beliefs that are not based in reality.
3. Disorganized thinking and speech: Difficulty organizing thoughts and expressing them in a clear and logical manner.
4. Disorganized behavior: Incoherent or bizarre behavior, such as dressing inappropriately for the weather or neglecting personal hygiene.
5. Catatonia: A state of immobility or abnormal movement, such as rigidity or agitation.
6. Negative symptoms: A decrease in emotional expression or motivation, such as a flat affect or a lack of interest in activities.
7. Cognitive impairment: Difficulty with attention, memory, and other cognitive functions.
8. Social withdrawal: Avoidance of social interactions and relationships.
9. Lack of self-care: Neglecting personal hygiene, nutrition, and other basic needs.
10. Suicidal or homicidal ideation: Thoughts of harming oneself or others.

It's important to note that not everyone with schizophrenia will experience all of these symptoms, and some people may experience additional symptoms not listed here. Additionally, the severity and frequency of symptoms can vary widely from person to person. With proper treatment and support, many people with schizophrenia are able to manage their symptoms and lead fulfilling lives.

1. Predominantly Inattentive Type: This type is characterized by symptoms of inattention, such as difficulty paying attention to details or making careless mistakes. Individuals with this type may have trouble sustaining their focus during tasks and may appear daydreamy or easily distracted.
2. Predominantly Hyperactive-Impulsive Type: This type is characterized by symptoms of hyperactivity, such as fidgeting, restlessness, and an inability to sit still. Individuals with this type may also exhibit impulsivity, such as interrupting others or speaking out of turn.
3. Combined Type: This type is characterized by both symptoms of inattention and hyperactivity-impulsivity.

The symptoms of ADHD can vary from person to person and may change over time. Some common symptoms include:

* Difficulty sustaining attention during tasks
* Easily distracted or interrupted
* Difficulty completing tasks
* Forgetfulness
* Fidgeting or restlessness
* Difficulty sitting still or remaining quiet
* Interrupting others or speaking out of turn
* Impulsivity, such as acting without thinking

The exact cause of ADHD is not fully understood, but research suggests that it may be related to differences in brain structure and function, as well as genetic factors. There is no cure for ADHD, but medication and behavioral therapy can help manage symptoms and improve functioning.

ADHD can have significant impacts on daily life, including academic and social difficulties. However, with proper treatment and support, many individuals with ADHD are able to lead successful and fulfilling lives.

The exact cause of depressive disorder is not fully understood, but it is believed to involve a combination of genetic, environmental, and psychological factors. Some common risk factors for developing depressive disorder include:

* Family history of depression
* Traumatic events, such as abuse or loss
* Chronic stress
* Substance abuse
* Chronic illness or chronic pain

There are several different types of depressive disorders, including:

* Major depressive disorder (MDD): This is the most common type of depression, characterized by one or more major depressive episodes in a person's lifetime.
* Persistent depressive disorder (PDD): This type of depression is characterized by persistent, low-grade symptoms that last for two years or more.
* Bipolar disorder: This is a mood disorder that involves periods of both depression and mania or hypomania.
* Postpartum depression (PPD): This is a type of depression that occurs in women after childbirth.
* Severe depression: This is a severe and debilitating form of depression that can interfere with daily life and relationships.

Treatment for depressive disorder typically involves a combination of medication and therapy, such as antidepressant medications and cognitive-behavioral therapy (CBT). Other forms of therapy, such as psychodynamic therapy or interpersonal therapy, may also be effective. Lifestyle changes, such as regular exercise, healthy eating, and getting enough sleep, can also help manage symptoms.

It's important to seek professional help if you or someone you know is experiencing symptoms of depressive disorder. With proper treatment, many people are able to recover from depression and lead fulfilling lives.

The symptoms of cyclothymic disorder can vary in severity and frequency, but may include:

* Mild depression, such as feeling sad or hopeless for extended periods of time
* Hypomania, which is characterized by elevated or irritable moods that are not severe enough to interfere with daily life
* Increased energy and activity level
* Poor concentration and decision-making abilities
* Changes in appetite and sleep patterns
* Increased anxiety and physical tension

Cyclothymic disorder is considered a milder form of bipolar disorder, and individuals with this condition may experience more subtle changes in mood and behavior than those with bipolar I or II disorder. However, like bipolar disorder, cyclothymic disorder can have a significant impact on an individual's quality of life, relationships, and ability to function in daily life.

Treatment for cyclothymic disorder typically involves medication, such as mood stabilizers or antidepressants, and psychotherapy, such as cognitive-behavioral therapy or interpersonal therapy. Lifestyle changes, such as regular exercise and stress management techniques, may also be helpful in managing symptoms of the disorder.

It is important to note that cyclothymic disorder is a chronic condition, meaning that it can persist for years or even a lifetime if left untreated. However, with proper treatment and support, individuals with cyclothymic disorder can learn to manage their symptoms and improve their overall quality of life.

Types of Cognition Disorders: There are several types of cognitive disorders that affect different aspects of cognitive functioning. Some common types include:

1. Attention Deficit Hyperactivity Disorder (ADHD): Characterized by symptoms of inattention, hyperactivity, and impulsivity.
2. Traumatic Brain Injury (TBI): Caused by a blow or jolt to the head that disrupts brain function, resulting in cognitive, emotional, and behavioral changes.
3. Alzheimer's Disease: A progressive neurodegenerative disorder characterized by memory loss, confusion, and difficulty with communication.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to cognitive impairment and other symptoms.
5. Parkinson's Disease: A neurodegenerative disorder that affects movement, balance, and cognition.
6. Huntington's Disease: An inherited disorder that causes progressive damage to the brain, leading to cognitive decline and other symptoms.
7. Frontotemporal Dementia (FTD): A group of neurodegenerative disorders characterized by changes in personality, behavior, and language.
8. Post-Traumatic Stress Disorder (PTSD): A condition that develops after a traumatic event, characterized by symptoms such as anxiety, avoidance, and hypervigilance.
9. Mild Cognitive Impairment (MCI): A condition characterized by memory loss and other cognitive symptoms that are more severe than normal age-related changes but not severe enough to interfere with daily life.

Causes and Risk Factors: The causes of cognition disorders can vary depending on the specific disorder, but some common risk factors include:

1. Genetics: Many cognitive disorders have a genetic component, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Age: As people age, their risk of developing cognitive disorders increases, such as Alzheimer's disease, vascular dementia, and frontotemporal dementia.
3. Lifestyle factors: Factors such as physical inactivity, smoking, and poor diet can increase the risk of cognitive decline and dementia.
4. Traumatic brain injury: A severe blow to the head or a traumatic brain injury can increase the risk of developing cognitive disorders, such as chronic traumatic encephalopathy (CTE).
5. Infections: Certain infections, such as meningitis and encephalitis, can cause cognitive disorders if they damage the brain tissue.
6. Stroke or other cardiovascular conditions: A stroke or other cardiovascular conditions can cause cognitive disorders by damaging the blood vessels in the brain.
7. Chronic substance abuse: Long-term use of drugs or alcohol can damage the brain and increase the risk of cognitive disorders, such as dementia.
8. Sleep disorders: Sleep disorders, such as sleep apnea, can increase the risk of cognitive disorders, such as dementia.
9. Depression and anxiety: Mental health conditions, such as depression and anxiety, can increase the risk of cognitive decline and dementia.
10. Environmental factors: Exposure to certain environmental toxins, such as pesticides and heavy metals, has been linked to an increased risk of cognitive disorders.

It's important to note that not everyone with these risk factors will develop a cognitive disorder, and some people without any known risk factors can still develop a cognitive disorder. If you have concerns about your cognitive health, it's important to speak with a healthcare professional for proper evaluation and diagnosis.

Types of Substance-Related Disorders:

1. Alcohol Use Disorder (AUD): A chronic disease characterized by the excessive consumption of alcohol, leading to impaired control over drinking, social or personal problems, and increased risk of health issues.
2. Opioid Use Disorder (OUD): A chronic disease characterized by the excessive use of opioids, such as prescription painkillers or heroin, leading to withdrawal symptoms when the substance is not available.
3. Stimulant Use Disorder: A chronic disease characterized by the excessive use of stimulants, such as cocaine or amphetamines, leading to impaired control over use and increased risk of adverse effects.
4. Cannabis Use Disorder: A chronic disease characterized by the excessive use of cannabis, leading to impaired control over use and increased risk of adverse effects.
5. Hallucinogen Use Disorder: A chronic disease characterized by the excessive use of hallucinogens, such as LSD or psilocybin mushrooms, leading to impaired control over use and increased risk of adverse effects.

Causes and Risk Factors:

1. Genetics: Individuals with a family history of substance-related disorders are more likely to develop these conditions.
2. Mental health: Individuals with mental health conditions, such as depression or anxiety, may be more likely to use substances as a form of self-medication.
3. Environmental factors: Exposure to substances at an early age, peer pressure, and social environment can increase the risk of developing a substance-related disorder.
4. Brain chemistry: Substance use can alter brain chemistry, leading to dependence and addiction.

Symptoms:

1. Increased tolerance: The need to use more of the substance to achieve the desired effect.
2. Withdrawal: Experiencing symptoms such as anxiety, irritability, or nausea when the substance is not present.
3. Loss of control: Using more substance than intended or for longer than intended.
4. Neglecting responsibilities: Neglecting responsibilities at home, work, or school due to substance use.
5. Continued use despite negative consequences: Continuing to use the substance despite physical, emotional, or financial consequences.

Diagnosis:

1. Physical examination: A doctor may perform a physical examination to look for signs of substance use, such as track marks or changes in heart rate and blood pressure.
2. Laboratory tests: Blood or urine tests can confirm the presence of substances in the body.
3. Psychological evaluation: A mental health professional may conduct a psychological evaluation to assess symptoms of substance-related disorders and determine the presence of co-occurring conditions.

Treatment:

1. Detoxification: A medically-supervised detox program can help manage withdrawal symptoms and reduce the risk of complications.
2. Medications: Medications such as methadone or buprenorphine may be prescribed to manage withdrawal symptoms and reduce cravings.
3. Behavioral therapy: Cognitive-behavioral therapy (CBT) and contingency management are effective behavioral therapies for treating substance use disorders.
4. Support groups: Joining a support group such as Narcotics Anonymous can provide a sense of community and support for individuals in recovery.
5. Lifestyle changes: Making healthy lifestyle changes such as regular exercise, healthy eating, and getting enough sleep can help manage withdrawal symptoms and reduce cravings.

It's important to note that diagnosis and treatment of substance-related disorders is a complex process and should be individualized based on the specific needs and circumstances of each patient.

Early Postmortem Changes:

1. Cessation of metabolic processes: After death, the body's metabolic processes come to a standstill, leading to a decrease in body temperature, cellular respiration, and other physiological functions.
2. Decline in blood pressure: The heart stops pumping blood, causing a rapid decline in blood pressure.
3. Cardiac arrest: The heart stops beating, leading to a lack of oxygen supply to the body's tissues.
4. Brain death: The brain ceases to function, causing a loss of consciousness and reflexes.
5. Rigor mortis: The muscles become stiff and rigid due to the buildup of lactic acid and other metabolic byproducts.
6. Livor mortis: Blood settles in the dependent parts of the body, causing discoloration and swelling.
7. Algor mortis: The body's temperature cools, causing the skin to feel cool to the touch.

Late Postmortem Changes:

1. Decomposition: Bacteria and other microorganisms begin to break down the body's tissues, leading to putrefaction and decay.
2. Autolysis: Enzymes within the body's cells break down cellular components, causing self-digestion and softening of the tissues.
3. Lipid decomposition: Fats and oils in the body undergo oxidation, leading to the formation of offensive odors.
4. Coagulative necrosis: Blood pools in the body's tissues, causing damage to the cells and tissues.
5. Putrefaction: Bacteria in the gut and other parts of the body cause the breakdown of tissues, leading to the formation of gases and fluids.

It is important to note that postmortem changes can significantly impact the interpretation of autopsy findings and the determination of cause of death. Therefore, it is essential to consider these changes when performing an autopsy and interpreting the results.

Explanation: Genetic predisposition to disease is influenced by multiple factors, including the presence of inherited genetic mutations or variations, environmental factors, and lifestyle choices. The likelihood of developing a particular disease can be increased by inherited genetic mutations that affect the functioning of specific genes or biological pathways. For example, inherited mutations in the BRCA1 and BRCA2 genes increase the risk of developing breast and ovarian cancer.

The expression of genetic predisposition to disease can vary widely, and not all individuals with a genetic predisposition will develop the disease. Additionally, many factors can influence the likelihood of developing a particular disease, such as environmental exposures, lifestyle choices, and other health conditions.

Inheritance patterns: Genetic predisposition to disease can be inherited in an autosomal dominant, autosomal recessive, or multifactorial pattern, depending on the specific disease and the genetic mutations involved. Autosomal dominant inheritance means that a single copy of the mutated gene is enough to cause the disease, while autosomal recessive inheritance requires two copies of the mutated gene. Multifactorial inheritance involves multiple genes and environmental factors contributing to the development of the disease.

Examples of diseases with a known genetic predisposition:

1. Huntington's disease: An autosomal dominant disorder caused by an expansion of a CAG repeat in the Huntingtin gene, leading to progressive neurodegeneration and cognitive decline.
2. Cystic fibrosis: An autosomal recessive disorder caused by mutations in the CFTR gene, leading to respiratory and digestive problems.
3. BRCA1/2-related breast and ovarian cancer: An inherited increased risk of developing breast and ovarian cancer due to mutations in the BRCA1 or BRCA2 genes.
4. Sickle cell anemia: An autosomal recessive disorder caused by a point mutation in the HBB gene, leading to defective hemoglobin production and red blood cell sickling.
5. Type 1 diabetes: An autoimmune disease caused by a combination of genetic and environmental factors, including multiple genes in the HLA complex.

Understanding the genetic basis of disease can help with early detection, prevention, and treatment. For example, genetic testing can identify individuals who are at risk for certain diseases, allowing for earlier intervention and preventive measures. Additionally, understanding the genetic basis of a disease can inform the development of targeted therapies and personalized medicine."


The exact cause of OCD is not known, but it is believed to involve a combination of genetic, environmental, and neurobiological factors. Symptoms of OCD can range from mild to severe and may include:

* Recurrent and intrusive thoughts or fears (obsessions)
* Repetitive behaviors or mental acts (compulsions) such as checking, counting, or cleaning
* Feeling the need to perform compulsions in order to reduce anxiety or prevent something bad from happening
* Feeling a sense of relief after performing compulsions
* Time-consuming nature of obsessions and compulsions that interfere with daily activities and social interactions

OCD can be treated with a combination of medications such as selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT). CBT helps individuals identify and challenge their obsessive thoughts and compulsive behaviors, while SSRIs help reduce the anxiety associated with OCD.

It's important to note that while individuals with OCD may recognize that their thoughts or behaviors are irrational, they are often unable to stop them without professional treatment. With appropriate treatment, however, many individuals with OCD are able to manage their symptoms and lead fulfilling lives.

The symptoms of PTSD can vary widely and may include:

1. Flashbacks or intrusive memories of the traumatic event
2. Nightmares or disturbed sleep
3. Avoidance of people, places, or activities that remind them of the event
4. Hypervigilance or an exaggerated startle response
5. Difficulty concentrating or memory problems
6. Irritability, anger, or other mood changes
7. Physical symptoms such as headaches, stomachaches, or muscle tension

The exact cause of PTSD is not fully understood, but it is thought to involve changes in the brain's response to stress and the release of chemical messengers (neurotransmitters) that help regulate emotions and memory.

PTSD can be diagnosed by a mental health professional using a combination of psychological evaluation and medical history. Treatment for PTSD typically involves therapy, medication, or a combination of both. Therapy may include exposure therapy, cognitive-behavioral therapy (CBT), or other forms of talk therapy. Medications such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants may be used to help manage symptoms.

Prevention is an important aspect of managing PTSD, and this includes seeking support from friends, family, or mental health professionals soon after the traumatic event. Self-care practices such as exercise, meditation, or relaxation techniques can also be helpful in reducing stress and promoting emotional well-being.

The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) defines Autistic Disorder as a pervasive developmental disorder that meets the following criteria:

A. Persistent deficits in social communication and social interaction across multiple contexts, including:

1. Deficits in social-emotional reciprocity (e.g., abnormal or absent eye contact, impaired understanding of facial expressions, delayed or lack of response to social overtures).
2. Deficits in developing, maintaining, and understanding relationships (e.g., difficulty initiating or sustaining conversations, impairment in understanding social norms, rules, and expectations).
3. Deficits in using nonverbal behaviors to regulate social interaction (e.g., difficulty with eye contact, facial expressions, body language, gestures).

B. Restricted, repetitive patterns of behavior, interests, or activities, as manifested by at least one of the following:

1. Stereotyped or repetitive motor movements, use of objects, or speech (e.g., hand flapping, head banging, repeating words or phrases).
2. Insistence on sameness, inflexibility, and adherence to routines or rituals.
3. Preoccupation with specific interests or activities that are repeated in a rigid and restricted manner (e.g., preoccupation with a particular topic, excessive focus on a specific activity).

C. Symptoms must be present in the early developmental period and significantly impact social, occupational, or other areas of functioning.

D. The symptoms do not occur exclusively during a medical or neurological condition (e.g., intellectual disability, hearing loss).

It is important to note that Autistic Disorder is a spectrum disorder and individuals with this diagnosis may have varying degrees of severity in their symptoms. Additionally, there are several other Pervasive Developmental Disorders (PDDs) that have similar diagnostic criteria but may differ in severity and presentation. These include:

A. Asperger's Disorder: Characterized by difficulties with social interaction and communication, but without the presence of significant delay or retardation in language development.

B. Rett Syndrome: A rare genetic disorder that is characterized by difficulties with social interaction, communication, and repetitive behaviors.

C. Childhood Disintegrative Disorder: Characterized by a loss of language and social skills that occurs after a period of normal development.

It is important to consult with a qualified professional, such as a psychologist or psychiatrist, for an accurate diagnosis and appropriate treatment.

The Diagnostic and Statistical Manual, Fifth Edition (DSM-V) defines BPD as a pervasive pattern of instability in interpersonal relationships, emotions, self-image, and behaviors, beginning by early adulthood and present in various contexts. People with BPD may exhibit the following symptoms:

1. Unstable relationships: People with BPD may have intense and unstable relationships that can change rapidly from idealization to devaluation.
2. Impulsivity: They may engage in impulsive behaviors, such as substance abuse, reckless spending, or risky sexual behavior, without considering the consequences.
3. Emptiness: Individuals with BPD may feel empty or hollow, leading to a sense of incompleteness or unfulfillment.
4. Self-harm: They may engage in self-destructive behaviors, such as cutting or burning themselves, as a coping mechanism for their emotional pain.
5. Fear of abandonment: People with BPD often have a deep-seated fear of being abandoned or rejected by those they care about.
6. Dissociation: They may experience dissociation, feeling detached from their body or surroundings, especially during times of stress or trauma.
7. Intense emotional dysregulation: Individuals with BPD may experience intense and frequent mood swings, difficulty regulating their emotions, and a heightened sensitivity to perceived rejection or criticism.
8. Identity issues: People with BPD may struggle with their sense of self, experiencing confusion about their identity and a feeling of being uncertain about their place in the world.
9. Disrupted family relationships: BPD can have a significant impact on family members, causing them to feel anxious, confused, or drained by the individual's behavior.
10. Stigma and misconceptions: Borderline personality disorder is often misunderstood and stigmatized, leading to further isolation and marginalization of individuals with BPD.

It's important to remember that every person with BPD is unique and may not exhibit all of these symptoms. However, by understanding the common experiences and challenges faced by individuals with BPD, we can better support them in their recovery and well-being.

Conduct disorder is a mental health condition that is characterized by a pattern of behavior in children and adolescents that violates the rights of others, as well as age-appropriate societal norms and rules. This condition can involve behaviors such as aggression to people or animals, destruction of property, deceitfulness, theft, and serious violations of rules.

Conduct disorder is also characterized by a lack of empathy, guilt, or remorse for one's actions, as well as a tendency towards impulsivity.

Symptoms of conduct disorder can include:

* Aggression to people or animals
* Destruction of property
* Deceitfulness
* Theft
* Serious violations of rules
* Disrespect for authority figures
* Lack of empathy, guilt, or remorse for one's actions
* Impulsivity
* Difficulty with self-control
* Antisocial behavior

Conduct disorder is diagnosed based on a combination of the child's symptoms and behavior, as well as an evaluation of their social and family history. Treatment for conduct disorder typically involves a combination of psychotherapy and medication.

Psychotherapy may involve:

* Cognitive-behavioral therapy (CBT) to help the child identify and change negative thought patterns and behaviors
* Family therapy to address any family dynamics that may be contributing to the child's behavior
* Social skills training to help the child learn appropriate social interactions and communication skills.

Medications that may be used to treat conduct disorder include:

* Stimulants, such as Ritalin (methylphenidate), to help with impulse control and attention
* Antipsychotics, such as Risperdal (risperidone), to help with aggression and irritability
* Antidepressants, such as Prozac (fluoxetine), to help with mood regulation.

It's important to note that conduct disorder is a mental health condition that can have serious consequences if left untreated. Children with conduct disorder are at an increased risk of developing other mental health conditions, such as depression and anxiety, as well as engaging in risky behaviors, such as substance abuse and delinquency. With appropriate treatment and support, however, it is possible for children with conduct disorder to learn healthy coping mechanisms, improve their social skills, and lead successful lives as adults.

1. Autism spectrum disorder: Children with autism spectrum disorder struggle with social interaction, communication and repetitive behaviors. They may also have delays or impairments in language development, cognitive and social skills.

2. Rett syndrome: A rare genetic condition that affects girls almost exclusively. Children with Rett syndrome typically develop normally for the first six months of life before losing skills and experiencing difficulties with communication, movement and other areas of functioning.

3. Childhood disintegrative disorder: This is a rare condition in which children develop normally for at least two years before suddenly losing their language and social skills. Children with this disorder may also experience difficulty with eye contact, imitation and imagination.

4. Pervasive developmental disorder-not otherwise specified (PDD-NOS): A diagnosis that is given to children who display some but not all of the characteristic symptoms of autism spectrum disorder. Children with PDD-NOS may have difficulties in social interaction, communication and repetitive behaviors.

5. Other specified and unspecified pervasive developmental disorders: This category includes a range of rare conditions that affect children's development and functioning. Examples include;
a) Fragile X syndrome: A genetic condition associated with intellectual disability, behavioral challenges and physical characteristics such as large ears and a long face.
b) Williams syndrome: A rare genetic condition that affects about one in 10,000 children. It is characterized by heart problems, developmental delays and difficulties with social interaction and communication.

These disorders can have a significant impact on the child's family and caregivers, requiring early intervention and ongoing support to help the child reach their full potential.

Pervasive child development disorder is a broad term used to describe a range of conditions that affect children's social communication and behavioral development. There are five main types of pervasive developmental disorders:
1. Autism spectrum disorder (ASD): A developmental disorder characterized by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. Children with ASD may have a hard time understanding other people's perspectives, initiating or maintaining conversations and developing and maintaining relationships. They may also exhibit repetitive behaviors such as hand flapping, rocking or repeating words or phrases.

2. Rett syndrome: A rare genetic disorder that affects girls almost exclusively. It is characterized by difficulties in social interaction, communication and repetitive behaviors, as well as physical symptoms such as seizures, tremors and muscle weakness. Children with Rett syndrome may also experience anxiety, depression and sleep disturbances.

3. Childhood disintegrative disorder: A rare condition in which children develop typically for the first few years of life, but then lose their language and social skills and exhibit autistic-like behaviors.

4. Pervasive developmental disorder-not otherwise specified (PDD-NOS): A diagnosis given to children who exhibit some, but not all, of the symptoms of ASD. Children with PDD-NOS may have difficulty with social interaction and communication, but do not meet the criteria for a full diagnosis of ASD.

5. Asperger's disorder: A milder form of autism that is characterized by difficulties with social interaction and communication, but not with language development. Children with Asperger's disorder may have trouble understanding other people's perspectives, developing and maintaining relationships and exhibiting repetitive behaviors.

it's important to note that these categories are not exhaustive and there is some overlap between them. Additionally, each individual with a pervasive developmental disorder may experience a unique set of symptoms and challenges.

ADHD is a neurodevelopmental disorder that affects both children and adults. It is characterized by symptoms of inattention, hyperactivity, and impulsivity. The most common symptoms of ADHD include difficulty paying attention, forgetfulness, fidgeting, interrupting others, and acting impulsively.

ODD is a disorder that is characterized by a pattern of negative, hostile, and defiant behavior towards authority figures. Symptoms of ODD may include arguing with adults, refusing to comply with rules, deliberately annoying others, and blaming others for one's own mistakes.

CD is a disorder that is characterized by a pattern of aggressive and destructive behavior towards others. Symptoms of CD may include physical fights, property damage, and cruelty to animals.

The causes of AD/DBD are not yet fully understood, but research suggests that a combination of genetic and environmental factors contribute to their development. These disorders often run in families, and individuals with AD/DBD are more likely to have a family history of these conditions. Additionally, certain environmental stressors, such as trauma or exposure to toxins, may increase the risk of developing AD/DBD.

There is no cure for AD/DBD, but they can be effectively managed with a combination of medication and behavioral therapy. Medications such as stimulants and non-stimulants are commonly used to treat ADHD, while behavioral therapies such as cognitive-behavioral therapy (CBT) and dialectical behavior therapy (DBT) can help individuals with AD/DBD learn skills to manage their symptoms and behaviors.

In conclusion, attention deficit hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD) are neurodevelopmental disorders that affect both children and adults. While they share some similarities, they also have distinct differences in terms of their symptoms and underlying causes. Effective management of these conditions requires a comprehensive approach that includes medication, behavioral therapy, and lifestyle changes. With appropriate treatment, individuals with ADHD and DBD can lead fulfilling lives and achieve their goals.

Some common examples of phobic disorders include:

1. Arachnophobia (fear of spiders)
2. Acrophobia (fear of heights)
3. Agoraphobia (fear of being in public places or situations where escape might be difficult)
4. Claustrophobia (fear of enclosed spaces)
5. Cynophobia (fear of dogs)
6. Glossophobia (fear of speaking in public)
7. Mysophobia (fear of germs or dirt)
8. Necrophobia (fear of death or dead things)
9. Ophidiophobia (fear of snakes)
10. Social phobia (fear of social situations or being judged by others)

Phobic disorders can cause significant distress and impairment in an individual's daily life, and can lead to avoidance behaviors that limit their ability to function in various contexts. Treatment for phobic disorders often involves exposure therapy, cognitive-behavioral therapy (CBT), or medication.

1. Insomnia: difficulty falling asleep or staying asleep
2. Sleep apnea: pauses in breathing during sleep
3. Narcolepsy: excessive daytime sleepiness and sudden attacks of sleep
4. Restless leg syndrome: uncomfortable sensations in the legs during sleep
5. Periodic limb movement disorder: involuntary movements of the legs or arms during sleep
6. Sleepwalking: walking or performing other activities during sleep
7. Sleep terrors: intense fear or anxiety during sleep
8. Sleep paralysis: temporary inability to move or speak during sleep
9. REM sleep behavior disorder: acting out dreams during sleep
10. Circadian rhythm disorders: disruptions to the body's internal clock, leading to irregular sleep patterns.

Sleep disorders can be caused by a variety of factors, such as stress, anxiety, certain medications, sleep deprivation, and underlying medical conditions like chronic pain or sleep apnea. Treatment for sleep disorders may include lifestyle changes (such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment), medications, and behavioral therapies (such as cognitive-behavioral therapy for insomnia). In some cases, surgery or other medical interventions may be necessary.

It is important to seek medical attention if you suspect that you or someone you know may have a sleep disorder, as untreated sleep disorders can lead to serious health problems, such as cardiovascular disease, obesity, and depression. A healthcare professional can help diagnose the specific sleep disorder and develop an appropriate treatment plan.

People with Antisocial Personality Disorder may exhibit a range of symptoms, including:

* A lack of empathy or remorse for harming others
* Impulsivity and a tendency to act on whim without considering the consequences
* Aggressive or violent behavior
* A disregard for the law and a willingness to engage in criminal activity
* Difficulty forming and maintaining relationships
* Inability to feel guilt or remorse
* Inability to take responsibility for one's actions
* A tendency to manipulate others for personal gain

It is important to note that Antisocial Personality Disorder is not the same as Asperger's Syndrome or Autism Spectrum Disorder, which are separate neurodevelopmental disorders. However, people with Antisocial Personality Disorder may also have co-occurring conditions such as substance use disorders or other mental health conditions.

Treatment for Antisocial Personality Disorder typically involves a combination of psychotherapy and medication. Cognitive-behavioral therapy (CBT) and psychodynamic therapy may be effective in helping individuals with this condition to understand and change their behavior. Medications such as antidepressants and antipsychotics may also be used to help manage symptoms.

It is important to note that Antisocial Personality Disorder is a complex and challenging condition to treat, and it is not uncommon for individuals with this disorder to have difficulty adhering to treatment plans or engaging in therapy. However, with the right treatment and support, it is possible for individuals with Antisocial Personality Disorder to learn new coping skills and make positive changes in their lives.

The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) defines alcohol use disorder as a maladaptive pattern of alcohol use that leads to clinically significant impairment or distress in at least three of the following areas:

1. Drinking more or for longer than intended.
2. Desire or unsuccessful efforts to cut down or control drinking.
3. Spending a lot of time drinking or recovering from its effects.
4. Craving or strong desire to drink.
5. Drinking interferes with work, school, or home responsibilities.
6. Continuing to drink despite social or personal problems caused by alcohol use.
7. Giving up important activities in order to drink.
8. Drinking in hazardous situations (e.g., while driving).
9. Continued drinking despite physical or psychological problems caused or worsened by alcohol use.
10. Developing tolerance (i.e., needing to drink more to achieve the desired effect).
11. Experiencing withdrawal symptoms when alcohol use is stopped or reduced.

The severity of alcoholism is categorized into three subtypes based on the number of criteria met: mild, moderate, and severe. Treatment for alcoholism typically involves a combination of behavioral interventions (e.g., cognitive-behavioral therapy, motivational interviewing) and medications (e.g., disulfiram, naltrexone, acamprosate) to manage withdrawal symptoms and cravings.

In conclusion, alcoholism is a chronic and often progressive disease characterized by excessive and compulsive consumption of alcohol despite negative consequences to physical and mental health, relationships, and social functioning. The diagnostic criteria for alcoholism include a combination of physiological, behavioral, and subjective symptoms, and treatment typically involves a combination of behavioral interventions and medications to manage withdrawal symptoms and cravings.

People with dysthymic disorder may experience a range of symptoms, including:

1. Persistent low mood or sadness
2. Lack of interest in activities they once enjoyed
3. Changes in appetite or sleep patterns
4. Fatigue or loss of energy
5. Difficulty concentrating or making decisions
6. Feelings of hopelessness or helplessness
7. Recurring thoughts of death or suicide

Dysthymic disorder can be challenging to diagnose because the symptoms are often mild and may not be as obvious as those experienced in major depressive disorder. Additionally, people with dysthymic disorder may have a hard time recognizing their symptoms or may attribute them to other factors, such as stress or personality traits.

Treatment for dysthymic disorder typically involves a combination of medication and psychotherapy, such as cognitive-behavioral therapy (CBT) or interpersonal therapy (IPT). Antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs), can help relieve symptoms of depression, while psychotherapy can help individuals identify and change negative thought patterns and behaviors that contribute to their depression.

It's important to note that dysthymic disorder is a chronic condition, meaning it can be ongoing and require long-term treatment. However, with the right treatment and support, it is possible for individuals with dysthymic disorder to manage their symptoms and improve their quality of life.

Some common types of memory disorders include:

1. Amnesia: A condition where an individual experiences memory loss, either partial or total, due to brain damage or other causes.
2. Dementia: A broad term that describes a decline in cognitive function, including memory loss, confusion, and difficulty with communication and daily activities. Alzheimer's disease is the most common cause of dementia.
3. Mild Cognitive Impairment (MCI): A condition characterized by memory loss and other cognitive symptoms that are more severe than normal age-related changes but not as severe as dementia.
4. Attention Deficit Hyperactivity Disorder (ADHD): A neurodevelopmental disorder that affects attention, impulse control, and hyperactivity. Memory problems are often a component of ADHD.
5. Traumatic Brain Injury (TBI): A condition that occurs when the brain is injured due to a blow or jolt to the head, which can result in memory loss and other cognitive problems.
6. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death and potential memory loss.
7. Meningitis: An inflammatory condition that affects the membranes covering the brain and spinal cord, which can lead to memory loss and other cognitive problems.
8. Encephalitis: An inflammatory condition that affects the brain directly, leading to memory loss and other cognitive problems.
9. Chronic Fatigue Syndrome (CFS): A condition characterized by persistent fatigue, memory loss, and other cognitive symptoms.
10. Sleep Disorders: Sleep disturbances can affect memory and cognitive function, including conditions such as insomnia, sleep apnea, and restless leg syndrome.

The diagnosis of memory disorders typically involves a combination of medical history, physical examination, laboratory tests, and neuropsychological evaluations. The specific treatment approach will depend on the underlying cause of the memory loss, but may include medication, behavioral interventions, and lifestyle changes.

There are several different types of tic disorders, including:

1. Tourette Syndrome: This is the most common type of tic disorder, and it is characterized by both motor and vocal tics. Motor tics can include simple movements such as blinking or facial grimacing, as well as more complex movements such as head jerking or arm flapping. Vocal tics can include repeated words or phrases, or other sounds such as grunting or sniffing.
2. Chronic Tic Disorder: This type of tic disorder is characterized by the presence of multiple motor and/or vocal tics that occur over a period of more than 1 year, but do not meet the criteria for Tourette Syndrome.
3. Provisional Tic Disorder: This type of tic disorder is characterized by the presence of fewer than 5 motor and/or vocal tics that occur over a period of less than 1 year.
4. Tic-like movements: These are movements or sounds that are similar to tics, but do not meet the full criteria for a tic disorder. Examples include stereotyped movements such as hand flapping or head banging, or repetitive sounds such as throat clearing or sniffing.

Tic disorders can have a significant impact on an individual's quality of life, and they may also be associated with other conditions such as attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and anxiety. Treatment options for tic disorders include medications such as dopamine blockers and antipsychotics, as well as behavioral therapies such as habit reversal training and exposure and response prevention.

Recurrence can also refer to the re-emergence of symptoms in a previously treated condition, such as a chronic pain condition that returns after a period of remission.

In medical research, recurrence is often studied to understand the underlying causes of disease progression and to develop new treatments and interventions to prevent or delay its return.

Examples of Impulse Control Disorders include:

1. Intermittent Explosive Disorder (IED): recurring episodes of sudden, violent, and aggressive outbursts, often resulting in property damage or physical harm to oneself or others.
2. Kleptomania: recurring failure to resist the impulse to steal, despite negative consequences.
3. Pyromania: recurring failure to resist the impulse to set fires, leading to deliberate and purposeful burning of property.
4. Pathological Gambling: persistent and recurring preoccupation with gambling, often leading to financial, legal, or relationship problems.
5. Trichotillomania (TTM): recurring urge to pull one's own hair, resulting in noticeable hair loss.
6. Dermatillomania: recurring urge to pick at or scratch one's own skin, leading to skin damage and scarring.
7. Compulsive Sexual Behavior (CSB): recurring and persistent preoccupation with sexual behavior, often resulting in negative consequences such as relationship problems, financial difficulties, or legal issues.

Treatment for Impulse Control Disorders often involves a combination of psychotherapy and medication. Cognitive-behavioral therapy (CBT) and habit reversal training are common therapeutic approaches used to help individuals identify and manage triggers, develop coping skills, and reduce the frequency and intensity of their compulsive behaviors. Medications such as selective serotonin reuptake inhibitors (SSRIs) may be prescribed to help reduce symptoms of anxiety or depression that may accompany ICDs.

It is important to note that while these disorders share some common features, they are distinct from one another and require individualized diagnosis and treatment.

Some common symptoms of affective disorders with psychotic features include:

* Depressed mood (lasting for two weeks or more)
* Loss of interest in activities that were once enjoyed
* Changes in appetite or sleep patterns
* Psychotic symptoms, such as hallucinations or delusions
* Disorganized thinking or speech
* Difficulty with concentration or memory
* Increased risk of suicide

Some common types of affective disorders with psychotic features include:

* Major depressive disorder with psychotic features
* Bipolar disorder with psychotic features
* Schizophrenia
* Brief psychotic disorder

Affective disorders with psychotic features can be treated with a combination of medications and therapy. Antipsychotic medications may be used to reduce the severity of psychotic symptoms, while antidepressant medications may be used to address underlying mood changes. Therapy, such as cognitive-behavioral therapy, can help individuals understand and manage their thoughts and behaviors related to the disorder.

It is important to seek medical attention if symptoms of an affective disorder with psychotic features are present, as early intervention can improve outcomes and reduce the risk of complications. A mental health professional can provide a proper diagnosis and recommend appropriate treatment.

1. Alcohol Use Disorder (AUD): A diagnosis given to individuals who have difficulty controlling their alcohol consumption and experience negative consequences as a result.
2. Alcohol Dependence Syndrome (ADS): A condition characterized by a strong psychological and physiological dependence on alcohol, leading to withdrawal symptoms when alcohol use is stopped suddenly.
3. Alcohol-Induced Neurological Disorders: Conditions such as Wernicke-Korsakoff syndrome, which affects memory and coordination, and delirium tremens, a severe form of alcohol withdrawal that can be life-threatening.
4. Alcohol-Related Liver Disease (ALD): A condition characterized by fatty liver disease, alcoholic hepatitis, and cirrhosis, which can lead to liver failure and other complications.
5. Heart Disease: Excessive alcohol consumption can damage the heart muscle, increase blood pressure and triglycerides, and increase the risk of heart attack and stroke.
6. Mental Health Disorders: Alcohol can worsen symptoms of mental health conditions such as depression, anxiety, and post-traumatic stress disorder (PTSD).
7. Nutritional Deficiencies: Poor nutrition and malabsorption associated with heavy alcohol consumption can lead to deficiencies in essential vitamins and minerals.
8. Immune System Suppression: Chronic alcohol consumption can weaken the immune system, making individuals more susceptible to infections like pneumonia and tuberculosis.
9. Pancreatitis: A painful inflammatory condition of the pancreas that can be triggered by heavy alcohol consumption.
10. Various Cancers: Excessive alcohol consumption has been linked to an increased risk of several types of cancer, including liver, breast, colon, and throat cancer.

It is important to note that these risks are often dose-dependent, meaning that the more alcohol consumed, the greater the risk of developing these health problems. Additionally, binge drinking, or consuming large amounts of alcohol in a short period, can significantly increase the risk of acute injuries and death.

1. Articulation Disorders: Difficulty articulating sounds or words due to poor pronunciation, misplaced sounds, or distortion of sounds.
2. Stuttering: A disorder characterized by the repetition or prolongation of sounds, syllables, or words, as well as the interruption or blocking of speech.
3. Voice Disorders: Abnormalities in voice quality, pitch, or volume due to overuse, misuse, or structural changes in the vocal cords.
4. Language Disorders: Difficulty with understanding, using, or interpreting spoken language, including grammar, vocabulary, and sentence structure.
5. Apraxia of Speech: A neurological disorder that affects the ability to plan and execute voluntary movements of the articulatory organs for speech production.
6. Dysarthria: A condition characterized by slurred or distorted speech due to weakness, paralysis, or incoordination of the articulatory muscles.
7. Cerebral Palsy: A group of disorders that affect movement, balance, and posture, often including speech and language difficulties.
8. Aphasia: A condition that results from brain damage and affects an individual's ability to understand, speak, read, and write language.
9. Dyslexia: A learning disorder that affects an individual's ability to read and spell words correctly.
10. Hearing Loss: Loss of hearing in one or both ears can impact speech development and language acquisition.

Speech disorders can be diagnosed by a speech-language pathologist (SLP) through a comprehensive evaluation, including speech and language samples, medical history, and behavioral observations. Treatment options vary depending on the specific disorder and may include therapy exercises, technology assistance, and counseling. With appropriate support and intervention, individuals with speech disorders can improve their communication skills and lead fulfilling lives.

The term "somatoform" refers to the fact that these disorders involve somatic (physical) symptoms, rather than psychotic or mood-related symptoms. Somatoform disorders can include conditions such as:

* Somatization disorder: characterized by multiple physical symptoms that are not easily explained by a medical condition, and which cause significant distress or impairment in daily life.
* Hypochondriasis: excessive preoccupation with the fear of having or acquiring a serious illness, despite medical reassurance that no such illness exists.
* Conversion disorder: characterized by physical symptoms that are thought to be related to an unconscious psychological conflict or stress.
* Factitious disorder: characterized by intentionally producing or feigning physical symptoms in order to gain attention, sympathy, or other benefits.

Somatoform disorders can be challenging to diagnose and treat, as they often involve complex interplay between psychological and physical factors. Treatment may involve a combination of psychotherapy and medication, and may require a multidisciplinary approach involving mental health professionals and medical specialists.

1. Somatic symptom disorder: This condition is characterized by persistent and excessive thoughts or concerns about physical symptoms, such as pain or gastrointestinal issues, despite medical evaluation and reassurance that no underlying medical condition exists.
2. Illness anxiety disorder: Formerly known as hypochondriasis, this disorder is characterized by an excessive preoccupation with the fear of having or acquiring a serious illness, despite evidence to the contrary.
3. Conversion disorder: This condition is characterized by symptoms that are not readily explainable by a medical or neurological condition, such as paralysis, blindness, or difficulty speaking. The symptoms are thought to be a manifestation of psychological conflicts or stressors.
4. Factitious disorder: Also known as Munchausen syndrome, this condition is characterized by the deliberate production or feigning of symptoms in order to gain attention, sympathy, or other forms of support.
5. Hypochondriasis: This condition is characterized by an excessive preoccupation with the fear of having or acquiring a serious illness, despite evidence to the contrary.
6. Health anxiety disorder: This condition is characterized by an excessive preoccupation with the fear of having or acquiring a serious illness, despite evidence to the contrary.
7. Medical phobia: This condition is characterized by an excessive fear of medical procedures or healthcare settings, which can lead to avoidance of necessary medical care and potential harm as a result.
8. Pain disorder: This condition is characterized by persistent and excessive pain that cannot be fully explained by a medical condition or injury. The pain can have a significant impact on an individual's daily life and functioning.
9. Psychogenic non-epileptic seizures: These are seizures that are not caused by a medical or neurological condition, but rather by psychological factors such as stress, anxiety, or other forms of emotional distress.
10. Somatic symptom disorder: This condition is characterized by persistent and excessive preoccupation with physical symptoms, such as pain, fatigue, or gastrointestinal issues, despite medical evidence that the symptoms are not caused by a medical condition or injury.

It's important to note that while these conditions are distinct from one another, they can sometimes overlap or co-occur, and it may be necessary to rule out other potential causes of the patient's symptoms before making a diagnosis. Additionally, individuals with mental health conditions may be at higher risk for developing somatoform disorders due to the emotional distress and maladaptive coping strategies that can accompany these conditions.

Chronobiology disorders can result when the body's natural circadian rhythm is disrupted or altered, leading to problems with sleep timing, duration, and quality, as well as other physiological and behavioral issues. Examples of chronobiology disorders include:

1. Circadian rhythm sleep disorders: These are conditions that affect the body's natural sleep-wake cycle, such as delayed sleep phase syndrome (DSPS) and advanced sleep phase disorder (ASPD).
2. Jet lag: This occurs when traveling across time zones, causing a mismatch between the body's internal clock and the local environment.
3. Shift work sleep disorder: This affects people who work outside of traditional daytime hours and experience difficulty adjusting to irregular sleep schedules.
4. Irregular sleep-wake patterns: This can be caused by factors such as working night shifts, rotating shifts, or having an irregular sleep schedule.
5. Sleep apnea: A sleep disorder in which a person's breathing is interrupted during sleep, often causing them to wake up frequently throughout the night.
6. Insomnia: Difficulty falling asleep or staying asleep, often caused by stress, anxiety, or other factors that disrupt the body's natural sleep-wake cycle.
7. Depression: A mood disorder that can affect the body's circadian rhythm, leading to changes in sleep patterns and other physiological functions.
8. Bipolar disorder: A mood disorder that can cause changes in sleep patterns, energy levels, and other physiological functions.
9. Seasonal affective disorder (SAD): A type of depression that occurs during the winter months when there is less sunlight.
10. Hypersomnia: Excessive sleepiness or prolonged periods of sleep, often caused by factors such as medication side effects, sleep disorders, or other medical conditions.

It's important to note that these are just a few examples of the many potential causes of irregular sleep patterns, and there may be other underlying factors that contribute to this symptom. If you are experiencing persistent changes in your sleep patterns, it is important to speak with a healthcare professional to determine the cause and find appropriate treatment.

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"Bipolar disorder: the assessment and management of bipolar disorder in adults, children and young people in primary and ... "Sequencing of substance use and affective morbidity in 166 first-episode bipolar I disorder patients". Bipolar Disorders. 10 (6 ... Psychotherapy also has a role in the treatment of bipolar disorder. The goal of treatment is not to cure the disorder but ... "The prevalence and significance of substance use disorders in bipolar type I and II disorder". Substance Abuse Treatment, ...
"Bipolar disorders beyond major depression and euphoric mania" (PDF). Bipolar disorders: Mixed states, rapid cycling and ... Bipolar disorder, Depression (mood), Mood disorders, History of mental disorders). ... Marneros, Andreas (2009). "The history of bipolar disorders". In Zarate, Carlos A.; Manji, Husseini K. (eds.). Bipolar ... Marneros, Andreas (2001). "Expanding the group of bipolar disorders". Journal of Affective Disorders. 62 (1): 39-44. doi: ...
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Jessie lives with Bipolar Disorder and Glenn talked about the perspective of the family and gave 2 monologues. The Depression ... Pauley lives with Bipolar Disorder. In the fall of 2008, DBSA Greater Houston published an outcome study independently ... The Depression and Bipolar Support Alliance of Greater Houston is a chapter member of the National Depression and Bipolar ... DBSA-Houston Website National Organization Website (Mental health organizations in Texas, Bipolar disorder). ...
Bipolar Disorders. 16 (2): 129-136. doi:10.1111/bdi.12123. PMID 24102676. S2CID 19393503. Jacques Mercier, Au coeur des mots: ...
Lithium is approved by the FDA for the treatment of bipolar disorder and is widely prescribed off-label as a treatment for ... "Mood Stabilizers for Bipolar Disorder (Manic Depressive)". Leeheymd.com. 2003-08-01. Retrieved 2011-11-21. Wing DA, Powers B, ... Carbamazepine, or Tegretol, has been used as a mood stabilizer and is accepted treatment for bipolar disorder. Clomiphene ( ... Quetiapine (Seroquel) for insomnia: quetiapine is approved for the treatment of schizophrenia and bipolar disorder. Retigabine ...
Tohen, Mauricio (1 February 2017). "Treatment Guidelines in Bipolar Disorders and the Importance of Proper Clinical Trial ... Tohen, Mauricio (2018). "Severity of symptoms in mania-clinical guidelines and study design implications". Bipolar Disorders. ... Genetic trials are conducted to assess the prediction accuracy of genetic disorders making a person more or less likely to ... "NINDS Guidelines for Monitoring in Clinical Trials , National Institute of Neurological Disorders and Stroke". ninds.nih.gov. ...
Bipolar Disorders, and the Journal of Affective Disorders. He was nominated as the official advisor on mood disorders research ... Guidelines for the Biological Treatment of Bipolar Disorders: Update 2012 on the long-term treatment of bipolar disorder" (PDF ... where he heads the Bipolar Disorders Program, a worldwide leader in the clinical care, research and teaching of bipolar ... "Bipolar Disorder". www. cibersam.es. Archived from the original on June 1, 2015. Retrieved June 4, 2015. "Eduard Vieta" (PDF). ...
They are used in the treatment of bipolar disorder, where they have a role in treating depression and mania and may reduce the ... P. B. Mitchell; D. Hadzi-Pavlovic (2000). "Lithium treatment for bipolar disorder" (PDF). Bulletin of the World Health ... Bipolar Disorders. 8 (5 Pt 2): 625-39. doi:10.1111/j.1399-5618.2006.00344.x. PMID 17042835. Beryllium at WebElements. Standards ...
2003). "Ziprasidone-associated mania: a case series and review of the mechanism". Bipolar Disorders. 5 (1): 72-75. doi:10.1034/ ... Nicolson, SE; Nemeroff, CB (December 2007). "Ziprasidone in the treatment of mania in bipolar disorder". Neuropsychiatr Dis ... 2007). "Risk of Diabetes Mellitus Associated with Atypical Antipsychotic Use Among Medicaid Patients with Bipolar Disorder: A ... is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It may be used by mouth and by injection into a ...
In bipolar disorder, lamotrigine has not been shown to reliably treat acute depression; but for patients with bipolar disorder ... Lamotrigine is approved in the US for maintenance treatment of bipolar I disorder and bipolar II disorder. While the ... hallucinogen persisting perception disorder, schizoaffective disorder, and borderline personality disorder. It has not been ... Goldsmith DR, Wagstaff AJ, Ibbotson T, Perry CM (1 October 2003). "Lamotrigine: a review of its use in bipolar disorder". Drugs ...
... is useful in the treatment of bipolar disorder. Lithium salts may also be helpful for related diagnoses, such as ... A 2022 review indicated that lithium therapy during treatment of bipolar disorder does not affect body weight. Lithium metal is ... For instance, studies of lithium-treated patients with bipolar disorder show that, among many other effects, lithium partially ... Shorter, Edward (June 2009). "The history of lithium therapy". Bipolar Disorders. 11 (Suppl 2): 4-9. doi:10.1111/j.1399- ...
"Assessing oxidative pathway genes as risk factors for bipolar disorder". Bipolar Disorders. 12 (5): 550-6. doi:10.1111/j.1399- ...
Specifically it is effective at lowering the risk of suicide in those with bipolar disorder and major depressive disorder. Some ... Bipolar Disorders. 19 (7): 575-586. doi:10.1111/bdi.12543. PMID 28895269. S2CID 39221887. Coppen A (2000). "Lithium in unipolar ... or substance abuse disorder Certain medical conditions Chronic pain A prior suicide attempt Family history of a mental disorder ... Chuang, L., "Mental Disorders Secondary to General Medical Conditions", Medscape, archived from the original on October 19, ...
Barbini, B (2005). "Dark Therapy for Mania: a pilot study". Bipolar Disorders. 7 (1): 98-101. doi:10.1111/j.1399-5618.2004. ... Phelps, James (2008-01-01). "Dark therapy for bipolar disorder using amber lenses for blue light blockade". Medical Hypotheses ... "Dark therapy for bipolar disorder using amber lenses for blue light blockade". Medical Hypotheses. 70 (2): 224-229. doi:10.1016 ... Bipolar Disorders. 18 (3): 221-232. doi:10.1111/bdi.12390. PMC 5089565. PMID 27226262. Franke, L.; Sülflow, D.; Stark, K.; ...
... attention deficit hyperactivity disorder (ADHD); autism spectrum disorder (ASD); bipolar disorder; blindness and visual ... obsessive-compulsive disorder; post-traumatic stress disorder (PTSD); reactive attachment disorder (RAD); schizophrenia; spina ... dissociative identity disorder (DID); Down syndrome; dwarfism; dyslexia; epilepsy; fetal alcohol syndrome disorders (FASD); ... generalized anxiety disorder; hearing impairment; hydrocephalus; limb deformity, loss, or reduction; major depression; ...
People with bipolar disorder, Pseudonymous artists, Dutch expatriates in France, Dutch expatriates in Belgium, 20th-century ...
... bipolar disorder, major depressive disorder), that mass shootings have become more common than other forms of mass murder since ... However, like the APA, the researchers emphasized that having a formal mental health disorder diagnosis is more predictive of ... and a psychotic disorder in only 3 cases). The survey concludes that given the high lifetime prevalence of the symptoms of ... and that only one-fourth of active shooters surveyed had a formal diagnosis of any mental health disorder ( ...
Jones I, Chandra PS, Dazzan P, Howard LM (November 2014). "Bipolar disorder, affective psychosis, and schizophrenia in ... Around one per cent of women with eclampsia die.[medical citation needed] A puerperal disorder or postpartum disorder is a ... Childbirth-related posttraumatic stress disorder is a psychological disorder that can develop in women who have recently given ... Pre-eclampsia is a disorder of pregnancy in which there is high blood pressure and either large amounts of protein in the urine ...
Her character, named Marta Ventura, suffers bipolar disorder. She has also appeared in the same year in the film Os Penetras. ... Mariana Trigo (December 24, 2011). "Personagem bipolar desafia atriz Juliana Schalch em minissérie" (in Portuguese). Terra. ...
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Sharpless's childhood and young adulthood were marked by her struggles with bipolar disorder, a condition only diagnosed in her ... and even after learning she was bipolar the difficulties caused by the disorder persisted as doctors tried different ...
... and mental illnesses including schizophrenia and bipolar disorder. Together, diseases of poverty kill approximately 14 million ... Human diseases and disorders, Public health, Poverty, Epidemiology, Health economics, Social problems in medicine). ...
96875882-96986592 Bipolar disorder lithium response (continuous) or schizophrenia - Loci associated with Bipolar disorder ... The protein has been phenotypically associated with bipolar disease due to its locus, as well as body mass index (BMI), and ... Mutations have been associated with periphery neuropathy, and sensory disorders. It is highly expressed in the spinal cord, as ...
Series connection is also sometimes used to adapt polarized electrolytic capacitors for bipolar AC use. Voltage distribution in ... P. (2006). Fractals, diffusion and relaxation in disordered complex systems. Part A. Wiley. p. 17. ISBN 0-470-04607-4. 2005 ...
... bipolar disorders, eating disorders, personality disorders, schizophrenia disorders, trauma and stress-related disorders, etc. ... Abnormal genital development includes disorders of fetal origin, disorders in androgen synthesis or action, disorders in anti- ... "Disorders of Sex Development Loci☆". Disorders of Sex Development Loci. Elsevier. doi:10.1016/B978-0-12-809633-8.06552-3. ISBN ... Such disorders include partial or complete gonadal dysgenesis, ovotesticular DSD, testicular DSD and sex reversal. Genital ...
Downey's stepmother Rosemary told author Alex Tresnlowski that Downey had been diagnosed with bipolar disorder "a few years ago ... "the Bipolar Association" asking him about being bipolar. When Downey denied he had ever said he was bipolar, the caller quoted ... Malibusian said [I said I was bipolar] ... ', and they go, 'Well, it's been written, so we're going to quote it.'" Downey ... I asked him flat out if he thought he was bipolar, and he said, 'Oh yeah. There are times I spend a lot of money and I'm ...
Pettigrew used binocular rivalry as an assay for interhemispheric switching, whose rhythm is altered in bipolar disorder. ...
People with bipolar disorder, People from Schenectady, New York, 1952 births, 2015 deaths, Shock jocks). ... announced that he had been diagnosed with bipolar disorder and had attempted suicide. After undergoing another round of ...
The novels feature protagonist Natalie King, a forensic psychiatrist with bipolar disorder. Medea's Curse was shortlisted for ...
People with bipolar disorder, People with traumatic brain injuries, People with schizophrenia, 20th-century executions of ... He had "a mental disorder which for a considerable period rendered him insane." Dr. Thompson W. Grace was called to the house ... Throughout his life physicians and alienists thought heredity played some role in his mental disorders. A great deal is known ...
The film tells the story of Hess's life and how his struggles with alcoholism and bipolar disorder have impacted his life and ...
... major depressive disorder, bipolar disorder and schizophrenia, and identifying biomarkers for better diagnosis and novel ... The Pritzker Neuropsychiatric Disorders Research Consortium is a collaborative research enterprise by leading academic and ... The consortium is focused on discovering the neurobiological and genetic causes of three major psychiatric disorders, ...
... although some historians now think it could have been bi-polar disorder), most notably Princess Feodora of Saxe-Meiningen. This ...
John Cade, Australian psychiatrist who pioneered the use of lithium in bipolar disorder. Lieutenant Colonel Sir Ernest Edward " ...
Kat and Serena's mother who also suffers from bipolar disorder and was once a figure skater herself Jamie Champagne as Drew ... Bipolar disorder in fiction, Figure skating on television, English-language Netflix original programming, Television shows ... a competitive ice skater secretly struggling with bipolar disorder Willow Shields as Serena Baker, Kat's younger half-sister ...
People with bipolar disorder, People from Katoomba, New South Wales, National Art School alumni). ...
O'Riordan struggled with depression and the pressure of her own success, and was diagnosed with bipolar disorder in 2015. She ... In May 2017, O'Riordan publicly discussed her bipolar disorder, stating that she had been diagnosed in 2015. According to one ... People with bipolar disorder, The Cranberries members, The Voice of Ireland, Zoë Records artists, 21st-century Irish women ... singers, Love Da Records artists, People with mood disorders). ...
The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disorders 18: 440 ... such as anxiety disorders, depression, post-traumatic stress disorder, complaining disorders and bonding disorders (emotional ... Postpartum bipolar disease belongs to the bipolar spectrum, whose disorders exist in two contrasting forms - mania and ... Bipolar Disorders 15: 394-404. Wesseloo R, Kamperman A M, Munk-Olsen T, Pop V J M, Kushner S A, Bergink V (2016) Risk of ...
... was about her fear of re-entering the music industry following bipolar disorder, post-traumatic stress disorder and ADHD, only ...
Simone was diagnosed with bipolar disorder by a friend of De Bruin, who prescribed Trilafon for her. Despite the illness, it ... Simone was diagnosed with bipolar disorder in the late 1980s. She was known for her temper and outbursts of aggression. In 1985 ... People with bipolar disorder, Philips Records artists, RCA Victor artists, Roman Catholic activists, Singer-songwriters from ...
Mood stabilizers (used primarily to treat Bipolar disorder) such as lithium or lamotrigine may be of some use to help depressed ... Comorbid disorders, particularly substance use disorders, can complicate attempts to achieve remission. Psychotherapies and ... "Borderline Personality Disorder Medications - Learn More About Borderline Personality Disorder Medications". Bpd.about.com. ... DBT can be based on a biosocial theory of personality functioning in which BPD is seen as a biological disorder of emotional ...
... may refer to: MDP syndrome, a rare genetic disorder Manic depressive psychosis, also known as bipolar disorder Mesolimbic ...
... used to manage epilepsy and bipolar disorder), and selective serotonin reuptake inhibitors (SSRIs) (used to treat major ... A condition is considered X-linked if the gene that causes the disorder is located on the X chromosome (one of the two sex ... In these cases, the disorder is typically inherited from the maternal parent. Because RPS6KA3 is located on the X chromosome, ... Because stimulus-induced drop attacks (SIDAs) can result in physical harm to patients with the disorder, the use of medication ...
She wrote about her tough battle with chronic depression and bi-polar disorder. On 15 July 2013 she released her fourth studio ...
Learn about bipolar disorder, including signs and symptoms, types, risk factors, how it is diagnosed, and potential treatments ... Bipolar Disorder Studies for Adults. Featured Publications About Bipolar Disorder. Bipolar Disorder. This brochure presents ... Bipolar disorder and other conditions. Many people with bipolar disorder also have other mental disorders or conditions such as ... Bipolar Disorder. Overview. Bipolar disorder (formerly called manic-depressive illness or manic depression) is a mental illness ...
Bipolar disorder is a mental condition in which a person has wide or extreme swings in their mood. Periods of feeling sad and ... People with bipolar disorder are at high risk for suicide. They may use alcohol or other substances. This can make the bipolar ... Bipolar and related disorders. In: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ... Bipolar disorder is a mental condition in which a person has wide or extreme swings in their mood. Periods of feeling sad and ...
Bipolar Disorder[majr:noexp] AND humans[mh] AND english[la] AND last 1 Year [edat] AND (patient education handout[pt] OR ... The efficacy of lumateperone on symptoms of depression in bipolar I and bipolar II disorder: Secondary and post hoc analyses. ... Olanzapine/Samidorphan in Young Adults With Schizophrenia, Schizophreniform Disorder, or Bipolar I Disorder Who Are Early in ... Bipolar Disorder[majr:noexp] AND humans[mh] AND english[la] AND last 1 Year [edat] AND (patient education handout[pt] OR ...
Bipolar disorder is a mood disorder that can cause intense mood swings. Its also called manic depression. Learn about the ... What are the types of bipolar disorder?. There are three main types of bipolar disorder:. *Bipolar I disorder involves manic ... What is bipolar disorder?. Bipolar disorder is a mood disorder that can cause intense mood swings:. *Sometimes you may feel ... Bipolar Disorder (National Institute of Mental Health) Also in Spanish * Types of Bipolar Disorder (National Institute of ...
Studies in adults point to strong comorbidity between bipolar disorder and eating disorder. This study demonstrates the same ... Youth with bipolar disorder (BD) have a high risk of eating disorders (EDs), new research shows. ... Youth With Bipolar Disorder at High Risk of Eating Disorders - Medscape - Jun 06, 2022. ... Bipolar Disorder Tied to a Sixfold Increased Risk of Early Death * Patient Skepticism Rises; Psychiatric Follow-up Care Falls ...
TREATMENT FOR BIPOLAR DISORDER Release Date: April 3, 1998 RFP AVAILABLE: NIH-NIMH-98-DS-0001 P.T. National Institute of Mental ... Data from the study should be able to inform the provision of care in broad categories of people with bipolar disorder in the ... The purpose of this contract is to launch a major public study that will provide data to optimize treatment of bipolar disorder ... NIMH-98-DS-0001 entitled "Treatment for Bipolar Disorder" as Full and Open Competition under SIC Code 8093. This will be the ...
In patients with these disorders, mood can range from elation or mania to deep depression. ... Mood disorders are the most common chronic psychiatric disorders in the world and are a leading cause of morbidity. ... Heritability of mood disorders ranges from 50% in major depression to 80% in bipolar disorder. [4] Bipolar disorder, in ... Association between the DAOA/G72 gene and bipolar disorder and meta-analyses in bipolar disorder and schizophrenia. Bipolar ...
2019)‎. Bipolar disorder. World Health Organization. Regional Office for the Eastern Mediterranean. https://extranet.who.int/ ...
Bipolar, or manic-depressive, disorder is a condition that afflicts millions. Characterized by cycles of elation followed by ... The average person with bipolar disorder may go through as many as 10 or 12 cycles of mania and subsequent depression in a ... While such drugs as Paxil, Prozac, and Zoloft have proven effective in the treatment of bipolar disorder among humans, there is ... was found Monday to suffer from bipolar disorder. ... because of His bipolar condition, He is not in control of His ...
The results are part of the large-scale, multi-site Systematic Treatment Enhancement Program for Bipolar Disorder ... For depressed people with bipolar disorder who are taking a mood stabilizer, adding an antidepressant medication is no more ... Study Sheds Light on Medication Treatment Options for Bipolar Disorder. For depressed people with bipolar disorder who are ... Bipolar disorder (http://www.nimh.nih.gov/health/topics/bipolar-disorder/index.shtml), a sometimes debilitating illness marked ...
NIMH experts conducted a Facebook Live event on bipolar disorder in adults. ... Although bipolar disorder can occur even later in life. Occasionally, children may experience bipolar disorder symptoms, ... Now, psychiatrists recognize at least four types of bipolar disorder, although we recognize that bipolar disorder probably ... Can hypomania turn into bipolar I or bipolar II? Absolutely it can. And while the diagnosis of bipolar I or bipolar II is ...
All MeSH CategoriesPsychiatry and Psychology CategoryMental DisordersMood DisordersBipolar and Related DisordersBipolar ... Bipolar Disorder. A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency ...
Bipolar Disorder. What is bipolar disorder?. Bipolar disorder, also known as manic-depressive illness, is a brain disorder that ... How is bipolar disorder treated?. To date, there is no cure for bipolar disorder. But proper treatment helps most people with ... A person with bipolar disorder may need to take thyroid medication, in addition to medications for bipolar disorder, to keep ... How does bipolar disorder affect someone over time?. Bipolar disorder usually lasts a lifetime. Episodes of mania and ...
The therapy may be effective in the long-term treatment and relapse prevention of bipolar disorder (BD). ... which uses task fMRI to engage specific brain circuits affected by bipolar disorder before and after different forms of therapy ... Emotion-focused psychotherapy increases amygdala activation and connectivity in euthymic bipolar disorder. A randomized ... mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid ...
March 30 is World Bipolar Day. Its time to celebrate it differently. ... What Stories of "Overcoming" Bipolar Disorder Get Painfully Wrong. March 30 is World Bipolar Day. Its time to celebrate it ... Ive lived with bipolar disorder for more than 9,000 days. Some have been a joy, many have been a struggle, but all have been ... To me, the real heroes of bipolar disorder are the people who struggle but who get up every day and try again. The winners are ...
Bipolar disorder is a mental health condition that causes extreme fluctuations in thinking, mood, and behavior, known as ... Cyclothymic disorder (cyclothymia). Cyclothymic disorder is another type of bipolar disorder. With cyclothymic disorder, a ... The main types are bipolar I disorder and bipolar II disorder. Bipolar I involves depression and mania, an extremely high mood ... What causes bipolar disorder?. Experts do not know exactly why bipolar disorder happens, but it probably results from. a ...
See which vitamins are often used to help manage symptoms of bipolar disorder and the research behind them. ... Bipolar Disorder and Eating Disorders: Whats the Link?. Eating disorders - including binge eating disorder and bulimia - are ... Phases of Bipolar Disorder. Medically reviewed by Joslyn Jelinek, LCSW. Bipolar disorder can occur in phases and each phase has ... Aromatherapy For Bipolar Disorder. Introduction Aromatherapy can be a soothing treatment for Bipolar Disorder. This article ...
The probands were ascertained from consecutive referrals to the Mood Disorder Service, University Hospital, University of ... Complex segregation analyses were conducted on families of bipolar I and bipolar II probands to delineate the mode of ... Bipolar disorder: evidence for a major locus Am J Med Genet. 1995 Oct 9;60(5):370-6. doi: 10.1002/ajmg.1320600505. ... Complex segregation analyses were conducted on families of bipolar I and bipolar II probands to delineate the mode of ...
Learn more about the disorder, how to manage its symptoms, and more. ... Although the cause of bipolar disorder isnt known, there are effective treatments. ... Bipolar 1 Disorder Bipolar 2 Disorder Cyclothymic Disorder Mania Hypomania Depression Psychotherapy Major Depressive Disorder ... Is bipolar disorder genetic? Research suggests there is a strong genetic component in bipolar disorder. Twin studies have found ...
QuickStats: Average Annual Rate of Emergency Department Visits for Bipolar Disorder* Among Persons Aged ≥15 Years, by Age Group ... Visits for bipolar disorder were defined as those with any of the following International Classification of Diseases , Ninth ... 15 years with a diagnosis of bipolar disorder, an overall rate of 3.8 visits per 1,000 persons per year. The visit rate ... 15 years with a diagnosis of bipolar disorder, an overall rate of 3.8 visits per 1,000 persons per year. The visit rate ...
Neuroplasticity and cellular resilience in bipolar disorder / Husseini K. Manji. Author: Manji, Husseini K. National Institutes ... Neuroplasticity and Cellular Resilience in Bipolar Disorder ... Neuroplasticity and Cellular Resilience in Bipolar Disorder. ...
This restriction will unfortunately change the diagnoses of some patients from DSM-IV bipolar I and II disorders to ... an underdiagnosis of bipolar disorders and a large proportion of treated patients had to be allocated to the vague NOS groups ... bipolar disorders and mixed states are now operationally defined in DSM-5. In addition, hypomanic and manic episodes occurring ... accepted as criteria for bipolar disorders. The diagnosis of bipolarity now requires, as entry criterion A, not only the ...
Bipolar Disorder: A Guide for Patients and Families, 2nd Edition. 2006. ... How Family And Friends Can Help Those with Bipolar Disorder. *How Family and Friends of Those with Bipolar Disorder Can Help ... Body Rhythms and Bipolar Disorder. *Borderline Personality Disorder and Schizoaffective Disorder Show Symptoms Similar to ... Mental Health Conditions Similar but Distinct from Bipolar Disorder. *Movement on an Energy Continuum: Bipolar Disorder, Mania ...
Find the Right Bipolar Disorder Counsellor in Glasgow, SCT - Robert Brown CBT, MBACP; GMQ Counselling, MBACP; Mary MacInnes, ... Bipolar Disorder Counsellors What is the most successful approach to treating bipolar disorder?. Living with bipolar disorder ... What is the goal of therapy for bipolar disorder?. Therapy helps patients set up their lives to maintain stability so that ... What happens in therapy for bipolar disorder?. Because the patterns of mood switching and its triggers differ for each person ...
... which could explain why persons with the disorder are more likely to have - and die from - age-related diseases, according to ... Bipolar disorder may involve accelerated epigenetic aging, which could explain why persons with the disorder are more likely to ... Using blood samples, the researchers compared 22 patients with bipolar disorder, 16 siblings of bipolar patients and 20 healthy ... Tags: Aging, Bipolar Disorder, Blood, Cancer, Cell Nucleus, Chronic, Diet, DNA, Exercise, Medical School, Mental Health, ...
Bipolar II Disorder. This form of bipolar disorder includes the same depressive symptoms as bipolar I disorder, but is ... The Severe Shifts of Bipolar Disorder. For a long time, bipolar disorder was referred to as manic depressive disorder due to ... Other Specified or Unspecified Bipolar Related Disorders. To put it as simply as possible, these are bipolar disorder symptoms ... www.nimh.nih.gov/health/topics/bipolar-disorder/index.shtml. A crucial element to leading a healthy life with bipolar disorder ...
It may be hard to cope when your roommate has bipolar disorder. Learn about my experiences and how my roommate helped with my ... Effects of Bipolar Disorder on Family and Friends).. Managing Practical Details When Your Roommate Has Bipolar Disorder. I have ... roommate bipolar disorder roommate mental illness APA Reference. Lloyd, T. (2015, November 12). When Your Roommate Has Bipolar ... You Can Play a Critical Role in Recovery If Your Roommate Has Bipolar Disorder. The most important aspect of sharing a home ...
Similar Editorials : Narcissism and Personality Disorders Axes of Personality Disorders by Sam Vaknin.Personality disorders are ... Cluster B Personality Disorders by Sam Vaknin.The DSM-IV-TR (2000) defines a personality disorder as: "An enduring pattern of ... Histrionic Personality Disorder by Sam Vaknin.This immediately raises the question: Is this a real mental health disorder or a ... Narcissistic Personality Disorder - Diagnostic Criteria by Sam Vaknin.The Narcissistic Personality Disorder (NPD) is not a new ...
Bipolar disorder is characterized by periods of depression and mania. Are you familiar with key aspects of this challenging ... Bipolar disorder - sometimes classified as bipolar affective disorder or manic-depressive illness - is a common, severe, and ... Bipolar Disorder: Interactive Case Discussions and Practice Points 0.75 CME / ABIM MOC Credits ... Bipolar disorder is characterized by periods of deep, prolonged, and profound depression that alternate with periods of an ...
As someone living with a significant other with bipolar disorder, not only is it a challenge for the individual, but also for ... Living with Someone with Bipolar Disorder Just when you think things are going well for you and your loved one, your partner ... One of the keys to your survival as a caregiver is to see bipolar disorder as a disease of the brain, not just a mental illness ... The treatment of bipolar disorder is difficult by itself, but when coupled with OCD or other conditions, such as substance ...
  • Bipolar disorder (formerly called manic-depressive illness or manic depression) is a mental illness that causes unusual shifts in a person's mood, energy, activity levels, and concentration. (nih.gov)
  • In most people with bipolar disorder, there is no clear cause for the periods (episodes) of extreme happiness and high activity or energy (mania) or depression and low activity or energy (depression). (medlineplus.gov)
  • The efficacy of lumateperone on symptoms of depression in bipolar I and bipolar II disorder: Secondary and post hoc analyses. (nih.gov)
  • The Efficacy of Lumateperone in Patients With Bipolar Depression With Mixed Features. (nih.gov)
  • Preventive interventions for children of parents with depression, anxiety, or bipolar disorder: A quasi-experimental clinical trial. (nih.gov)
  • Bipolar disorder used to be called other names, including manic depression and manic-depressive disorder. (nih.gov)
  • In patients with these disorders, mood can range from elation or mania to deep depression. (medscape.com)
  • Heritability of mood disorders ranges from 50% in major depression to 80% in bipolar disorder. (medscape.com)
  • Characterized by cycles of elation followed by bouts of profound depression and despair, the disorder can wreak havoc on both the sufferer and his or her loved ones, particularly if it goes undetected and untreated for an extended period. (theonion.com)
  • The average person with bipolar disorder may go through as many as 10 or 12 cycles of mania and subsequent depression in a lifetime. (theonion.com)
  • Bipolar disorder ( http://www.nimh.nih.gov/health/topics/bipolar-disorder/index.shtml ), a sometimes debilitating illness marked by severe mood swings between depression and mania, is usually treated with mood stabilizers such as lithium, valproate, carbamazepine or other medications that reduce mania. (nih.gov)
  • However, depression is more common than mania in bipolar disorder, and depressive episodes tend to last longer than episodes of mania. (nih.gov)
  • Antidepressant medications are often used in addition to a mood stabilizer for treating bipolar depression, but they are thought to confer a serious risk of a switch from a depressive episode to a manic episode. (nih.gov)
  • Treating depression in people with bipolar disorder is notoriously difficult," said NIMH Director Thomas R. Insel. (nih.gov)
  • Results of STEP-BD indicate that careful management of mood stabilizer medications is a reasonable alternative to adding an antidepressant medication for treating bipolar depression," said Dr. Sachs. (nih.gov)
  • Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Depression: A Double-blind Placebo-controlled Study. (nih.gov)
  • Now, most people with bipolar disorder also have episodes of depression. (nih.gov)
  • It is possible for someone with bipolar disorder to experience a long-lasting period of unstable moods rather than discrete episodes of depression or mania. (athealth.com)
  • In addition to mania and depression, bipolar disorder can cause a range of moods, as shown on the scale. (athealth.com)
  • Bipolar disorder is a mental health condition involving alternating periods of depression, mania, or hypomania. (healthline.com)
  • Bipolar disorder, previously called manic depression, is a mental health condition that involves fluctuations in thinking, mood, and behavior. (healthline.com)
  • If you have bipolar disorder, you may experience periods of depression or mania. (healthline.com)
  • Bipolar I involves depression and mania, an extremely high mood. (healthline.com)
  • Bipolar II is more likely to involve depression and hypomania. (healthline.com)
  • Bipolar depression may be more likely if a person has another mental health condition, such as obsessive-compulsive disorder (OCD) or traits of borderline personality disorder (BPD) . (healthline.com)
  • Though some folks low in B12 report mood changes, depression, and mania, to date there's no direct correlation between its deficiency and bipolar disorder symptoms. (psychcentral.com)
  • However, the vitamin - known for its energy-boosting benefits to those deficient in it - might be helpful if bipolar disorder depression has you feeling fatigued. (psychcentral.com)
  • An older study found that people with bipolar disorder have too much of the mineral vanadium, which factors into mania and depression. (psychcentral.com)
  • SAM-e (S-Adenosyl-L-methionine) has antidepressant properties in some cases but is largely warned against for people with bipolar disorder depression because it may worsen mania . (psychcentral.com)
  • Bipolar I disorder involves episodes of severe mania and often depression. (verywellmind.com)
  • Several new subthreshold groups of depression, bipolar disorders and mixed states are now operationally defined in DSM-5. (springer.com)
  • Bipolar disorder is characterized by periods of deep, prolonged, and profound depression that alternate with periods of an excessively elevated or irritable mood known as mania. (medscape.com)
  • For a long time, bipolar disorder was referred to as manic depressive disorder due to the nature of dramatic shifts in mood commonly labeled mania and depression. (palmpartners.com)
  • Fortunately, I'd told my roommate what was happening to me, and had discussed how an episode of bipolar depression might look before I'd had one. (healthyplace.com)
  • In every generation since World War II, there is a higher incidence and an earlier age of onset of bipolar disorder and depression. (depression-guide.com)
  • Bipolar Disorder - Bipolar Disorder is the form of depressive illness in which the sufferer has periods of being on a high, as well as periods of depression. (depression-guide.com)
  • Bipolar I is a mood disorder marked by alternating periods of manic behavior and depression. (webmd.com)
  • Method: Participants with major depressive disorder (MDD) or bipolar depression (DSM-IV) underwent overnight PSG monitoring in a sleep laboratory. (nih.gov)
  • These findings are not only fascinating, they might lead to new ways to help people who sometimes struggle with reading social cues, including those with anxiety, depression, bipolar disorder, schizophrenia, or autism spectrum disorder. (nih.gov)
  • Bipolar disorder, formerly known as 'manic depression,' is characterized by episodes of intensely energetic and euphoric or irritable mood called 'mania' interspersed with periods of serious depression and lethargy. (nih.gov)
  • IRP Distinguished Investigator Kathleen Merikangas, Ph.D. , has spent her career conducting large population studies of mental health conditions like bipolar disorder and major depression. (nih.gov)
  • Between 2005 and 2013, they studied 242 adults with bipolar disorder, major depression, or no history of mood disorders. (nih.gov)
  • Importantly, among participants with bipolar disorder, the influence of sleep and activity on their moods was much stronger than in those with depression or no mood disorder, and the sleep- and movement-induced boosts in mood and energy level that they experienced took longer to return to more typical levels. (nih.gov)
  • There are three types of bipolar disorder. (nih.gov)
  • What are the types of bipolar disorder? (nih.gov)
  • Now, psychiatrists recognize at least four types of bipolar disorder, although we recognize that bipolar disorder probably exists on a spectrum of severity, ranging from mild to more severe. (nih.gov)
  • There are different types of bipolar disorder, and it affects everyone differently. (healthline.com)
  • Learn about various types of bipolar disorder. (depression-guide.com)
  • Though there are a few different types of bipolar disorder (bipolar I disorder, bipolar II disorder, and cyclothymic disorder), they all involve changes in a person's mood, energy, and activity. (health.com)
  • Now, an NIH-funded team at Baylor College of Medicine has demonstrated for the first time that extra copies of a gene that codes for a protein called Shank3 can cause manic episodes similar to those seen in some types of bipolar disorder [1]. (nih.gov)
  • Bipolar disorder can skip generations and take different forms in different individuals. (depression-guide.com)
  • For example, some people with bipolar II disorder experience hypomania, a less severe form of mania. (nih.gov)
  • Some people with bipolar disorder experience hypomania. (athealth.com)
  • People who receive a diagnosis of bipolar II will have at least one episode of hypomania. (healthline.com)
  • Bipolar II disorder involves a less severe form of mania called hypomania. (verywellmind.com)
  • Those who suffer from bipolar disorder also experience a minor form of mania called hypomania. (palmpartners.com)
  • The less severe form of high in bipolar disorder is hypomania . (depression-guide.com)
  • While those with bipolar I disorder tend to have the most intense emotions, people with bipolar II disorder may experience what's known as hypomania, or a less severe form of mania. (health.com)
  • Compared with the non-rapid-cycling, rapid-cycling bipolar disorder was associated with younger age at onset, higher persistence, more severe depressive symptoms, greater impairment from depressive symptoms, more out-of-role days from mania/hypomania, more anxiety disorders and an increased likelihood of using health services. (cambridge.org)
  • Sometimes a person might experience symptoms of bipolar disorder that do not match the three categories listed above, and this is referred to as "other specified and unspecified bipolar and related disorders. (nih.gov)
  • The person may not feel that anything is wrong, but family and friends may recognize changes in mood or activity levels as possible symptoms of bipolar disorder. (nih.gov)
  • What are the symptoms of bipolar disorder? (nih.gov)
  • The symptoms of bipolar disorder can vary. (nih.gov)
  • Medicines can help control the symptoms of bipolar disorder. (nih.gov)
  • Symptoms of bipolar disorder are severe. (athealth.com)
  • Symptoms of bipolar disorder are described below. (athealth.com)
  • There are various symptoms of bipolar disorder. (depression-guide.com)
  • This infographic presents common signs and symptoms of bipolar disorder in teens and young adults. (nih.gov)
  • Bipolar disorder is often diagnosed during late adolescence (teen years) or early adulthood. (nih.gov)
  • A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. (nih.gov)
  • Bipolar disorder - sometimes classified as bipolar affective disorder or manic-depressive illness - is a common, severe, and persistent mental illness. (medscape.com)
  • For a diagnosis of bipolar I disorder, a person will experience mania at some point. (healthline.com)
  • This type of bipolar disorder is marked by periods of depressive and hypomanic episodes without periods of full-blown mania. (verywellmind.com)
  • Almost all medications that effectively treat bipolar mania lead to weight gain, and the one medication commonly prescribed to help, topiramate (Topamax), can negatively affect cognitive function. (dummies.com)
  • Lack of insight, a common symptom of bipolar mania, prevents a person from recognizing symptoms. (dummies.com)
  • Bipolar I disorder is defined by manic episodes that last for at least 7 days (nearly every day for most of the day) or by manic symptoms that are so severe that the person needs immediate medical care. (nih.gov)
  • Bipolar II disorder is defined by a pattern of depressive episodes and hypomanic episodes. (nih.gov)
  • The hypomanic episodes are less severe than the manic episodes in bipolar I disorder. (nih.gov)
  • Cyclothymic disorder (also called cyclothymia) is defined by recurring hypomanic and depressive symptoms that are not intense enough or do not last long enough to qualify as hypomanic or depressive episodes. (nih.gov)
  • Bipolar I disorder involves manic episodes that last at least 7 days or manic symptoms so severe that you need immediate hospital care. (nih.gov)
  • This type of bipolar disorder can also involve mixed episodes. (nih.gov)
  • Bipolar II disorder involves depressive episodes. (nih.gov)
  • Patients with bipolar I disorder typically demonstrate at least one major manic episode and usually also a major depressive episode, while those with bipolar II disorder typically show a pattern of depressive symptoms and hypomanic episodes. (medscape.com)
  • People with bipolar disorder have manic episodes. (nih.gov)
  • People with bipolar disorder experience unusually intense emotional states that occur in distinct periods called "mood episodes. (athealth.com)
  • A person with bipolar disorder can also experience manic or hypomanic episodes. (healthline.com)
  • Bipolar disorder is a mental health condition defined by periods (or episodes) of extreme mood disturbances that affect mood, thoughts, and behavior. (verywellmind.com)
  • In addition, hypomanic and manic episodes occurring during antidepressant treatments are, under certain conditions, accepted as criteria for bipolar disorders. (springer.com)
  • The main lines of the DSM-5 definition of major depressive episodes (MDE), basic to the diagnoses of both bipolar I and bipolar II disorders, are similar to those of DSM-IV: presence of five of nine diagnostic symptoms with a minimum duration of 2 weeks and a change from previous functioning. (springer.com)
  • The definitions of both manic and hypomanic episodes have been radically revised, which will impact on both bipolar diagnoses. (springer.com)
  • The depressive aspect of bipolar disorder is associated with depressive episodes. (palmpartners.com)
  • This form of bipolar disorder includes the same depressive symptoms as bipolar I disorder, but is characterized by shifts to hypomanic episodes. (palmpartners.com)
  • Are Bipolar Mood Episodes Different From Typical Mood Swings? (health.com)
  • Bipolar mood episodes consist of very high highs and extremely low lows for long periods. (health.com)
  • While the mood episodes associated with bipolar disorder are also unusual, they may not always be extreme-or as extreme as one might assume. (health.com)
  • What Can Trigger Bipolar Mood Episodes? (health.com)
  • But there are some common triggers for bipolar mood episodes. (health.com)
  • Researchers assessed improvements based on a standardized questionnaire to detect manic episodes, the elevated mood states that are a hallmark of this disorder. (nih.gov)
  • In rare cases , a person with bipolar disorder may experience catatonia . (healthline.com)
  • It's also possible for a person with bipolar disorder to experience both manic and depressive feelings in the same episode-that's known as an episode with mixed features. (health.com)
  • In a recent NAMI meeting I attended, the parents of children with bipolar disorder shared their experiences with the sudden changes in behavior that make each day, week and month a challenge. (nami.org)
  • On average, children with bipolar disorder experience their first episode of illness 10 years earlier than their parents' generation did. (depression-guide.com)
  • Receiving the right diagnosis and treatment can help people with bipolar disorder lead healthy and active lives. (nih.gov)
  • The researchers used the Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children, Present and Lifetime Version (K-SADS-PL) to determine the diagnosis of BD. (medscape.com)
  • NEW HAVEN, CT-In a diagnosis that helps explain the confusing and contradictory aspects of the cosmos that have baffled philosophers, theologians, and other students of the human condition for millennia, God, creator of the universe and longtime deity to billions of followers, was found Monday to suffer from bipolar disorder. (theonion.com)
  • The research in my lab is aimed at discovering and characterizing genes that are involved in mood and anxiety disorders so that better methods of diagnosis and treatment can be developed. (nih.gov)
  • Visits for bipolar disorder were defined as those with any of the following International Classification of Diseases , Ninth Revision , Clinical Modification diagnosis codes: 296.0, 296.1, or 296.4-296.8. (cdc.gov)
  • During 2010-2011, approximately 468,000 emergency department visits were made each year by persons aged ≥15 years with a diagnosis of bipolar disorder, an overall rate of 3.8 visits per 1,000 persons per year. (cdc.gov)
  • The date was selected to coincide with the birthday of Vincent Van Gogh, one of the most famous artists to have ever lived and a prime example of someone who eventually achieved traditional success despite his struggles with bipolar disorder (a diagnosis many experts have posthumously assigned him). (slate.com)
  • Importance of Bipolar disorder diagnosis Diagnosis is important, because it guides treatment decisions. (depression-guide.com)
  • This brochure presents information on bipolar disorder including symptoms, causes, diagnosis, treatment options, and resources to find help for yourself or others. (nih.gov)
  • This brochure provides information about bipolar disorder in children and teens including its causes, signs and symptoms, diagnosis, treatment options, and how to help and support a child or teen who has bipolar disorder. (nih.gov)
  • In addition, while about 2.3 million Americans have a diagnosis of bipolar disorder, it is likely many more people go undiagnosed. (nih.gov)
  • In fact, physical activity has now been included as one of the core features in the diagnosis of bipolar disorder. (nih.gov)
  • Cyclothymic disorder , or cyclothymia, also involves hypomanic and depressive symptoms. (nih.gov)
  • Bipolar disorder usually appears during adolescence or early adulthood, but it can occur at any age, including childhood . (healthline.com)
  • Genetics are thought to play a significant role, although brain abnormalities and environmental factors also contribute as causes of bipolar disorder. (verywellmind.com)
  • What role does genetics or family history play in bipolar disorder? (depression-guide.com)
  • The cause of bipolar disorder is likely a combination of different factors like genetics, hormone imbalances, or significant stressors in life. (health.com)
  • TREATMENT FOR BIPOLAR DISORDER Release Date: April 3, 1998 RFP AVAILABLE: NIH-NIMH-98-DS-0001 P.T. National Institute of Mental Health The National Institute of Mental Health proposes to issue a solicitation (RFP) No. NIMH-98-DS-0001 entitled "Treatment for Bipolar Disorder" as Full and Open Competition under SIC Code 8093. (nih.gov)
  • The results are part of the large-scale, multi-site Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), a $26.8 million clinical trial funded by the National Institutes of Health's National Institute of Mental Health (NIMH). (nih.gov)
  • The National Institute of Mental Health (NIMH) mission is to reduce the burden of mental and behavioral disorders through research on mind, brain, and behavior. (nih.gov)
  • Este folleto explica lo que es el trastorno bipolar, sus síntomas y causas, cómo se diagnostica, las opciones de tratamiento, dónde conseguir ayuda y las investigaciones que el NIMH está llevando a cabo para abordar este trastorno. (nih.gov)
  • However, research conducted at the National Institute of Mental Health (NIMH) is transforming our knowledge of one such mental health condition that affects more than two million Americans: bipolar disorder. (nih.gov)
  • There is also a third type known as cyclothymic disorder . (verywellmind.com)
  • Cyclothymic disorder, also known as cyclothymia, is slightly more complex. (palmpartners.com)
  • And welcome to World Bipolar Day. (nih.gov)
  • March 30 is World Bipolar Day. (slate.com)
  • March 30 marks World Bipolar Day, used to raise awareness of and celebrate those who live with the condition. (slate.com)
  • Treatment can help many people, including those with the most severe forms of bipolar disorder. (nih.gov)
  • This type of bipolar disorder involves the presence of at least one manic episode. (verywellmind.com)
  • According to the National Institute of Mental Health, there are four basic forms of bipolar disorder. (palmpartners.com)
  • To put it as simply as possible, these are bipolar disorder symptoms that do not match the description of any of the other three forms of bipolar disorder. (palmpartners.com)
  • The exact cause of bipolar disorder is unknown. (nih.gov)
  • A person may be having an episode of bipolar disorder if he or she has a number of manic or depressive symptoms for most of the day, nearly every day, for at least one or two weeks. (athealth.com)
  • In some cases, a stressful life event can trigger a person's first episode of bipolar disorder. (healthline.com)
  • Along with the mood swings, bipolar disorder causes changes in behavior, energy levels, and activity levels. (nih.gov)
  • Olanzapine/Samidorphan in Young Adults With Schizophrenia, Schizophreniform Disorder, or Bipolar I Disorder Who Are Early in Their Illness: Results of the Randomized, Controlled ENLIGHTEN-Early Study. (nih.gov)
  • The purpose of this contract is to launch a major public study that will provide data to optimize treatment of bipolar disorder in adults and older persons. (nih.gov)
  • During the next half hour together today, we'll be focusing on bipolar disorder in adults. (nih.gov)
  • Estimates suggest that around 4.4% of U.S. adults will have bipolar disorder at some point in their lives. (verywellmind.com)
  • For years, doctors have prescribed the drug lithium to treat adults with bipolar disorder, a brain disorder marked by extreme mood swings from emotional highs to depressive lows. (nih.gov)
  • It should include patients with complicating diagnostic comorbidities (substance abuse, other mental disorders, other physical or neurological illnesses), the need for multiple medications, and a wide variety of demographic characteristics (age, sex, race or ethnicity, residential setting). (nih.gov)
  • The overall objective of this initiative is to develop a research-validated multimodal approach to the acute treatment and long-term management of bipolar disorder in a representative sample of patients selected from a broad range of health care settings. (nih.gov)
  • [ 14 , 15 ] Nevertheless, mechanisms behind therapeutic agents used in patients with the disorder have lent support to the possible role of a few different genetic pathways and mutations. (medscape.com)
  • [ 44 ] Most studies on the GSK3B gene in bipolar disorder have been negative, but one study reported an increased number of copy-number variations (deletions or duplications) within the gene in a small sample of bipolar disorder patients. (medscape.com)
  • This restriction will unfortunately change the diagnoses of some patients from DSM-IV bipolar I and II disorders to subdiagnostic bipolar syndromes. (springer.com)
  • Fast Five Quiz: Are You Prepared to See Patients With Bipolar Disorder? (medscape.com)
  • What we found is that patients with bipolar disorder showed an accelerated epigenetic aging compared to healthy controls. (news-medical.net)
  • Using blood samples, the researchers compared 22 patients with bipolar disorder, 16 siblings of bipolar patients and 20 healthy controls. (news-medical.net)
  • They also found that while older bipolar disorder patients had significantly accelerated epigenetic aging compared to controls, no difference was found in younger patients. (news-medical.net)
  • The researchers initially tested their hypothesis in mice and then, building upon those findings, went on to find extra copies of the SHANK3 gene in two human patients-one with seizures and attention deficit hyperactivity disorder and another with seizures and bipolar disorder. (nih.gov)
  • Based on this work and their own observations of patients with bipolar disorder, Dr. Merikangas and her research group set out to home in on the relationships between physical activity, sleep, and mood in patients with bipolar disorder in real-world settings. (nih.gov)
  • People with bipolar disorder experience periods of unusually intense emotion and changes in sleep patterns and activity levels, and engage in behaviors that are out of character for them-often without recognizing their likely harmful or undesirable effects. (nih.gov)
  • Those with bipolar disorder experience periods of unusually intense emotions. (health.com)
  • Unlike most clinical studies, participants were recruited from clinical settings and were included in the study even if they were being treated for co-existing disorders such as substance abuse, anxiety or psychotic symptoms. (nih.gov)
  • Anxiety disorder often accompanies bipolar disorder. (psychcentral.com)
  • The article is "Daring to feel: Emotion-focused psychotherapy increases amygdala activation and connectivity in euthymic bipolar disorder. (elsevier.com)
  • A single dominant, mendelian major locus was the best fitting of these models for the sample of bipolar I and II probands when only bipolar relatives were defined as affected (polygenic inheritance could not be tested). (nih.gov)
  • Although bipolar disorder can occur even later in life. (nih.gov)
  • Essentially, people with cyclothymia have milder symptoms than what occur in full-blown bipolar disorder. (palmpartners.com)
  • Bipolar disorder can occur in adolescents and has been investigated by federally funded teams in children as young as age 6. (depression-guide.com)
  • And it's a real pleasure to join my colleague, Dr. Merikangas, today to talk with you about bipolar disorder. (nih.gov)
  • Wearable activity monitors allowed a research team led by IRP Distinguished Investigator Kathleen Merikangas to study how sleep and movement affect the moods of people with bipolar disorder and other mood disorders. (nih.gov)
  • When we studied adolescents in the general population, we learned that one of the most important characteristics of youth who begin to develop bipolar disorder is increased physical activity and energy rather than changes in mood," Dr. Merikangas says. (nih.gov)
  • These unidirectional links suggest that increasing physical activity may be a way that we could intervene in bipolar disorder," Dr. Merikangas says. (nih.gov)
  • Everyone experiences normal ups and downs, but with bipolar disorder, the range of mood changes can be extreme. (nih.gov)
  • The mood changes caused by bipolar disorder are very different from the highs and lows that are familiar to most people. (healthline.com)
  • Bipolar disorder is characterized by mood changes that can last from a few months to a few years. (psychcentral.com)
  • The exact cause is not known, but it occurs more often in relatives of people with bipolar disorder. (medlineplus.gov)
  • People with bipolar disorder are at high risk for suicide . (medlineplus.gov)
  • Some people with bipolar disorder may have milder symptoms. (nih.gov)
  • The primary study should focus on understanding what interventions (pharmacologic and psychosocial) provide the best outcomes (both clinical and functional) for different types of people and various stages of the disorder. (nih.gov)
  • Data from the study should be able to inform the provision of care in broad categories of people with bipolar disorder in the community. (nih.gov)
  • For depressed people with bipolar disorder who are taking a mood stabilizer, adding an antidepressant medication is no more effective than a placebo (sugar pill), according to results published online on March 28, 2007 in the New England Journal of Medicine . (nih.gov)
  • The results suggest that antidepressants are safe but not more effective than placebo as assessed in a large number of people with bipolar disorder. (nih.gov)
  • Such open recruitment criteria allows the study's results to have broader applicability than a tightly controlled trial in which people are excluded from participating if they have co-existing disorders. (nih.gov)
  • And our work in the Intramural Program involves studying the familial patterns of bipolar disorder so that we can understand what runs in families and identify early signs of the manifestations of bipolar disorder so that we can identify people early so that we might be able to prevent the consequences of this condition. (nih.gov)
  • But bipolar disorder can be treated, and people with this illness can lead full and productive lives. (athealth.com)
  • People with bipolar disorder also may be explosive and irritable during a mood episode. (athealth.com)
  • People with certain genetic factors may have a higher chance of developing bipolar disorder, and it appears to be more common in those who have a close relative with the disorder. (healthline.com)
  • People with bipolar disorder often experience extreme highs and lows in their moods. (healthline.com)
  • Some people look to help lighten the load of bipolar disorder symptoms with vitamins and supplements. (psychcentral.com)
  • but for some people with bipolar disorder , mood fluctuations are more extreme and can significantly disrupt their daily lives. (health.com)
  • Yet, they barely scratch the surface of the absurdities that people with bipolar and their loved ones often face, particularly when psychosis enters the picture. (dummies.com)
  • People with bipolar disorder and their loved ones often have a great sense of humor, perhaps because they tend to be smarter than average or because bipolar disorder creates situations that appear to have been written for the theater of the absurd. (dummies.com)
  • Since its first description in 1974, Reference Dunner and Fieve 1 rapid-cycling bipolar disorder has been shown to be present in about 12-24% of people with bipolar disorders at specialised mood disorder clinics in Western countries. (cambridge.org)
  • The purpose of this study is to determine the safety, tolerability, and feasibility of psilocybin therapy in people with Bipolar II Disorder. (clinicaltrials.gov)
  • At Harvard Medical School, Boston, Yankner and his colleague George Church are now recipients of an NIH Director's 2016 Transformative Research Award to apply what they've learned about the aging brain to study changes in the brains of younger people with schizophrenia and bipolar disorder, two poorly understood psychiatric disorders. (nih.gov)
  • Nearly 90 percent of people with bipolar disorder are affected severely enough to interfere with work, school, and relationships. (nih.gov)
  • The moods of people with bipolar disorder vacillate between depressive lows and euphoric highs. (nih.gov)
  • Interventions that spur people with bipolar disorder to be more physically active could help them regulate their moods. (nih.gov)
  • In fact, one of the most consistent findings in our studies and others across the world is that people with bipolar disorder tend to spend more time with lower levels of physical activity and lower energy levels than people without the condition. (nih.gov)
  • They also collected information about comorbid psychiatric disorders, as well as substance use disorders and cigarette smoking. (medscape.com)
  • Mood disorders are the most common chronic psychiatric disorders in the world and are a leading cause of morbidity. (medscape.com)
  • [ 33 ] Findings of circadian rhythm- elated genes support the continued study of these genes in bipolar disorder and lithium response. (medscape.com)
  • [ 34 , 35 ] were found to be associated with bipolar disorder in multiple samples, and expression analysis in rodents following administration of lithium or valproate indicated a role for FAT in neurodevelopment signaling pathways. (medscape.com)
  • Now a new study confirms that lithium is appropriate for children diagnosed with the form of the disorder known as bipolar type 1. (nih.gov)
  • Also, children taking lithium didn't experience significant metabolic side effects-and particularly weight gain-as compared to other medications for bipolar disorder. (nih.gov)
  • This review aims to discuss issues related to the learning process in children and adolescents with bipolar disorder, reflecting on learning problems, learning difficulties secondary to other disorders, and learning disorders, and their relation with the cognitive and academic deficits. (bvsalud.org)
  • Bipolar disorder's a mental illness that occurs occasionally at irregular intervals. (nih.gov)
  • Like diabetes or heart disease, bipolar disorder is a long-term illness that must be carefully managed throughout a person's life. (athealth.com)
  • When your roommate has bipolar disorder -- or any other mental illness -- they may, unwittingly, be responsible for taking care of you and managing their own reactions to your symptoms ( Effects of Bipolar Disorder on Family and Friends ). (healthyplace.com)
  • Bipolar disorder - a case study Millions of Americans diagnosed with mental illness lead healthy lives because of information discovered through clinical studies. (depression-guide.com)
  • Megan Fox and Bipolar Disorder - Her comments on the Acute Illness. (depression-guide.com)
  • The community epidemiological profile of rapid-cycling bipolar disorder confirms most but not all current clinically based knowledge about the illness. (cambridge.org)
  • Researchers are looking to certain U.S. states, including Ohio and Pennsylvania, to better understand bipolar disorder-a mental illness that. (medlineplus.gov)
  • The strength of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III, DSM-III-R and DSM-IV) was to base psychiatric diagnoses on defined operational criteria, which resulted in high inter-rater reliability. (springer.com)
  • Bipolar disorder may involve accelerated epigenetic aging, which could explain why persons with the disorder are more likely to have - and die from - age-related diseases, according to researchers from The University of Texas Health Science Center at Houston (UTHealth). (news-medical.net)
  • 2019)‎. Bipolar disorder. (who.int)
  • Bipolar disorder often develops in a person's late teens or early adult years. (athealth.com)
  • More serious mood swings-ones that can seriously threaten a person's well-being or impact their daily schedule-are a common characteristic of bipolar disorder. (health.com)
  • Before participants were randomized to one of two antidepressants - bupropion (Wellbutrin) or paroxetine (Paxil) - or to a placebo, doctors trained in the treatment of bipolar disorder adjusted participants' mood stabilizer doses to optimal levels, ensuring that they were receiving the most appropriate amount. (nih.gov)
  • Roughly a third and two-fifths of participants with lifetime and 12-month bipolar disorder respectively met criteria for rapid cycling. (cambridge.org)
  • Although the symptoms may vary over time, bipolar disorder usually requires lifelong treatment. (nih.gov)
  • While such drugs as Paxil, Prozac, and Zoloft have proven effective in the treatment of bipolar disorder among humans, there is no modern earthly medicine that can be prescribed for a deity as vast and complex as God. (theonion.com)
  • Future STEP-BD results will shed light on other treatment options for bipolar disorder, including psychotherapeutic treatments. (nih.gov)
  • The therapy may be effective in the long-term treatment and relapse prevention of bipolar disorder (BD). (elsevier.com)
  • Prescribed medication for bipolar disorder is a cornerstone of treatment. (psychcentral.com)
  • Treatment of Bipolar Disorder - Effective treatment is available for bipolar disorder. (depression-guide.com)
  • They require medical treatment from a trained psychiatrist, psychologist, or clinical social worker experienced in bipolar disorder management. (health.com)
  • The Composite International Diagnostic Interview (CIDI version 3.0) was used to examine the prevalence, severity, comorbidity, impairment, suicidality, sociodemographics, childhood adversity and treatment of rapid-cycling and non-rapid-cycling bipolar disorder in ten countries ( n = 54 257). (cambridge.org)
  • This may explain why physical activity interventions are beginning to show promise in the treatment of bipolar disorder. (nih.gov)
  • Cameron Carter, MD, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging , said of the work, "This study, which uses task fMRI to engage specific brain circuits affected by bipolar disorder before and after different forms of therapy, reveals new insights regarding their mechanisms of action in the brain. (elsevier.com)
  • Bipolar disorder has been previously associated with accelerated aging but the mechanisms are largely unknown,' said Gabriel R. Fries, Ph.D., first author and post-doctoral research fellow in the Department of Psychiatry and Behavioral Sciences at McGovern Medical School at UTHealth. (news-medical.net)