Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Antimanic Agents: Agents that are used to treat bipolar disorders or mania associated with other affective disorders.Lithium Compounds: Inorganic compounds that contain lithium as an integral part of the molecule.Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.Lithium Carbonate: A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.Diagnostic and Statistical Manual of Mental Disorders: Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)Psychiatric Status Rating Scales: Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Anxiety Disorders: Persistent and disabling ANXIETY.Depressive Disorder, Major: Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Valproic Acid: A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.Affect: The feeling-tone accompaniment of an idea or mental representation. It is the most direct psychic derivative of instinct and the psychic representative of the various bodily changes by means of which instincts manifest themselves.Irritable Mood: Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.Cyclothymic Disorder: An affective disorder characterized by periods of depression and hypomania. These may be separated by periods of normal mood.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Psychotropic Drugs: A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Substance-Related Disorders: Disorders related to substance abuse.Antidepressive Agents: Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Suicide, Attempted: The unsuccessful attempt to kill oneself.Lithium Chloride: A salt of lithium that has been used experimentally as an immunomodulator.Prefrontal Cortex: The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.Gyrus Cinguli: One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.Postmortem Changes: Physiological changes that occur in bodies after death.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Diagnosis, Dual (Psychiatry): The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.Interview, Psychological: A directed conversation aimed at eliciting information for psychiatric diagnosis, evaluation, treatment planning, etc. The interview may be conducted by a social worker or psychologist.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.DibenzothiazepinesStress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Borderline Personality Disorder: A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)Schizophrenic Psychology: Study of mental processes and behavior of schizophrenics.Amygdala: Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.Conduct Disorder: A repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate societal norms or rules are violated. These behaviors include aggressive conduct that causes or threatens physical harm to other people or animals, nonaggressive conduct that causes property loss or damage, deceitfulness or theft, and serious violations of rules. The onset is before age 18. (From DSM-IV, 1994)Child of Impaired Parents: Child with one or more parents afflicted by a physical or mental disorder.Personality Assessment: The determination and evaluation of personality attributes by interviews, observations, tests, or scales. Articles concerning personality measurement are considered to be within scope of this term.Expressed Emotion: Frequency and quality of negative emotions, e.g., anger or hostility, expressed by family members or significant others, that often lead to a high relapse rate, especially in schizophrenic patients. (APA, Thesaurus of Psychological Index Terms, 7th ed)Emotions: Those affective states which can be experienced and have arousing and motivational properties.Impulsive Behavior: An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.Creativity: The ability to generate new ideas or images.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Child Development Disorders, Pervasive: Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.Psychotherapy: A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.Attention Deficit and Disruptive Behavior Disorders: Includes two similar disorders: oppositional defiant disorder and CONDUCT DISORDERS. Symptoms occurring in children with these disorders include: defiance of authority figures, angry outbursts, and other antisocial behaviors.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Triazines: Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.Community Mental Health Centers: Facilities which administer the delivery of psychologic and psychiatric services to people living in a neighborhood or community.Functional Neuroimaging: Methods for visualizing REGIONAL BLOOD FLOW, metabolic, electrical, or other physiological activities in the CENTRAL NERVOUS SYSTEM using various imaging modalities.Personality Inventory: Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.Genome-Wide Association Study: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.Adolescent Psychiatry: The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in individuals 13-18 years.Phobic Disorders: Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.Family Therapy: A form of group psychotherapy. It involves treatment of more than one member of the family simultaneously in the same session.Suicide: The act of killing oneself.Facial Expression: Observable changes of expression in the face in response to emotional stimuli.Depression: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Anticonvulsants: Drugs used to prevent SEIZURES or reduce their severity.Sleep Disorders: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Child Psychiatry: The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in children.Endophenotypes: Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Cognitive Therapy: A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Antisocial Personality Disorder: A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Affective Symptoms: Mood or emotional responses dissonant with or inappropriate to the behavior and/or stimulus.Carbamazepine: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.Dysthymic Disorder: Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.Neuroimaging: Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Tic Disorders: Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)Aspirations (Psychology): Strong desires to accomplish something. This usually pertains to greater values or high ideals.Family: A social group consisting of parents or parent substitutes and children.Limbic System: A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)).Psychotherapy, Group: A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.Recurrence: The return of a sign, symptom, or disease after a remission.Cognition: Intellectual or mental process whereby an organism obtains knowledge.Psychometrics: Assessment of psychological variables by the application of mathematical procedures.Impulse Control Disorders: Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.Family Health: The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.Social Behavior Disorders: Behaviors which are at variance with the expected social norm and which affect other individuals.Executive Function: A set of cognitive functions that controls complex, goal-directed thought and behavior. Executive function involves multiple domains, such as CONCEPT FORMATION, goal management, cognitive flexibility, INHIBITION control, and WORKING MEMORY. Impaired executive function is seen in a range of disorders, e.g., SCHIZOPHRENIA; and ADHD.Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.Electroconvulsive Therapy: Electrically induced CONVULSIONS primarily used in the treatment of severe AFFECTIVE DISORDERS and SCHIZOPHRENIA.Affective Disorders, Psychotic: Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.Benzodiazepines: A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Attention: Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.Alcohol-Related Disorders: Disorders related to or resulting from abuse or mis-use of alcohol.Speech Disorders: Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.Dominance, Cerebral: Dominance of one cerebral hemisphere over the other in cerebral functions.Checklist: Aid for consistent recording of data such as tasks completed and observations noted.Early Medical Intervention: Action taken to reduce susceptibility or exposure to health problems and to detect and treat disease in early stages.Psychopathology: The study of significant causes and processes in the development of mental illness.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Demography: Statistical interpretation and description of a population with reference to distribution, composition, or structure.Somatoform Disorders: Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Sensory Gating: The ability of the BRAIN to suppress neuronal responses to external sensory inputs, such as auditory and visual stimuli. Sensory filtering (or gating) allows humans to block out irrelevant, meaningless, or redundant stimuli.Frontal Lobe: The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.United StatesNeuropsychiatry: A subfield of psychiatry that emphasizes the somatic substructure on which mental operations and emotions are based, and the functional or organic disturbances of the central nervous system that give rise to, contribute to, or are associated with mental and emotional disorders. (From Campbell's Psychiatric Dictionary, 8th ed.)Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Psychophysiologic Disorders: A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)Life Change Events: Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.Chronobiology Disorders: Disruptions of the rhythmic cycle of bodily functions or activities.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Anisotropy: A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.Nerve Fibers, Myelinated: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.

The social and economic effects of manic depressive illness and of its treatment in lithium clinics. (1/2554)

Advising about the employment of those who have had manic depressive episodes requires Occupational Health Physicians to obtain, with consent, an objective account of previous episodes and to appreciate the enormous range of manic and depressive manifestations. Familiarity is needed with the likely effects of treatment of episodes and the benefits and problems of prophylaxis--not just in general but in individual cases, for example, where driving is required. This article summarizes research into the effects of lithium preparations on the course of the illness, thyroid and renal function and the risk of suicide. The author found that changing from treatment of episodes to continuous prophylaxis benefited employment and personal relationships without causing body weight problems. Many patients do well in life if supported by an experienced professional team, with 61% requiring no further admissions once on lithium, and with an 86% reduction in admissions achieved in our local clinic.  (+info)

Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial. (2/2554)

Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT1A autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores < 8) at the end of treatment was 15/20 for pindolol, and 3/20 for placebo. Coadministration of pindolol and TSD resulted in a complete response, which could be sustained for six months with lithium salts alone, in 65% of cases. This results suggest a major role for serotonergic transmission in the mechanism of action of TSD, and makes TSD treatment more effective in the treatment of bipolar depression.  (+info)

A note on power approximations for the transmission/disequilibrium test. (3/2554)

The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.  (+info)

Acute barium intoxication following ingestion of ceramic glaze. (4/2554)

A case of deliberate overdose of barium sulphide in a psychiatric setting is presented, with resulting flaccid paralysis, malignant arrhythmia, respiratory arrest and severe hypokalaemia, but ultimately with complete recovery. The degree of paralysis appears to be related directly to serum barium levels. The value of early haemodialysis, particularly with respiratory paralysis and hypokalaemia, is emphasised.  (+info)

Pharmacogenetics of lithium response in bipolar disorder. (5/2554)

Lithium is the first-line treatment for bipolar disorder. In the past, genetic studies have attempted to identify factors associated with positive treatment response or side effects. Several research groups have shown that familial factors, family history of primary bipolar disorder, and negative family history of schizophrenia in particular, correlate well with prophylactic lithium response. Conversely, studies of lithium responsive patients and their families can assist genetic research of bipolar disorder. Lithium responders appear to suffer from a form of bipolar disorder that is more genetically based and more homogeneous. In a series of family studies, the author and his colleagues have confirmed the differences in family histories of lithium responders and nonresponders and shown that the mode of inheritance in lithium responders is compatible with a major-gene model. Subsequently, they initiated an international collaborative study to map the gene(s) predisposing to the illness or treatment response, or both, using both linkage and association strategies. To date, a sample of 32 families, 138 unrelated patients and 163 control subjects has been studied. In these studies, they found support for the role of phospholipase C in lithium responsive bipolar disorder.  (+info)

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. (6/2554)

Bipolar disorder is a severe mental illness characterized by mood swings of elation and depression. Family, twin, and adoption studies suggest a complex genetic etiology that may involve multiple susceptibility genes and an environmental component. To identify chromosomal loci contributing to vulnerability, we have conducted a genome-wide scan on approximately 396 individuals from 22 multiplex pedigrees by using 607 microsatellite markers. Multipoint nonparametric analysis detected the strongest evidence for linkage at 13q32 with a maximal logarithm of odds (lod) score of 3.5 (P = 0. 000028) under a phenotype model that included bipolar I, bipolar II with major depression, schizoaffective disorder, and recurrent unipolar disorder. Suggestive linkage was found on 1q31-q32 (lod = 2. 67; P = 0.00022) and 18p11.2 (lod = 2.32; P = 0.00054). Recent reports have linked schizophrenia to 13q32 and 18p11.2. Our genome scan identified other interesting regions, 7q31 (lod = 2.08; P = 0. 00099) and 22q11-q13 (lod = 2.1; P = 0.00094), and also confirmed reported linkages on 4p16, 12q23-q24, and 21q22. By comprehensive screening of the entire genome, we detected unreported loci for bipolar disorder, found support for proposed linkages, and gained evidence for the overlap of susceptibility regions for bipolar disorder and schizophrenia.  (+info)

Plasma catecholamine metabolites as markers for psychosis and antipsychotic response in schizophrenia. (7/2554)

The objective of this study was to determine the association between the patterns of change in the dopaminergic metabolite plasma homovanillic acid (HVA), the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), and psychosis following haloperidol withdrawal in schizophrenic patients. Weekly plasma measurements were obtained in 107 subjects with schizophrenia or schizoaffective disorder. Random regression was used to control for individual variance while modeling metabolite changes over time and relationships with psychosis. Changes in plasma MHPG were not significantly associated with relapse or psychosis, while increased plasma HVA was found to be associated with relapse. Psychosis was correlated negatively with plasma HVA levels. The current analysis, controlling for individual variance, indicates that there is evidence for pharmacological effects on plasma HVA, but not plasma MHPG. In addition, these metabolites do not appear to be direct markers of psychosis, but may be associated with a compensatory response by the system to return to the steady state.  (+info)

Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18. (8/2554)

Linkage disequilibrium (LD) analysis has been promoted as a method of mapping disease genes, particularly in isolated populations, but has not yet been used for genome-screening studies of complex disorders. We present results of a study to investigate the feasibility of LD methods for genome screening using a sample of individuals affected with severe bipolar mood disorder (BP-I), from an isolated population of the Costa Rican central valley. Forty-eight patients with BP-I were genotyped for markers spaced at approximately 6-cM intervals across chromosome 18. Chromosome 18 was chosen because a previous genome-screening linkage study of two Costa Rican families had suggested a BP-I locus on this chromosome. Results of the current study suggest that LD methods will be useful for mapping BP-I in a larger sample. The results also support previously reported possible localizations (obtained from a separate collection of patients) of BP-I-susceptibility genes at two distinct sites on this chromosome. Current limitations of LD screening for identifying loci for complex traits are discussed, and recommendations are made for future research with these methods.  (+info)

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks. Symptoms of bipolar disorder are severe. They are different from the normal ups and downs that everyone goes through from time to time. Bipolar disorder symptoms can result in damaged relationships, poor job or school performance, and even suicide. But bipolar disorder can be treated, and people with this illness can lead full and productive lives.. Causes. Scientists are studying the possible causes of bipolar disorder. Most scientists agree that there is no single cause. Rather, many factors likely act together to produce the illness or increase risk.. Genetics. Bipolar disorder tends to run in families. Some research has suggested that people with certain genes are more likely to develop bipolar disorder than others. Children with a parent or sibling who has bipolar disorder are much more likely to develop the ...
After reviewing numerous clinical trials, the American Heart Association issued a scientific statement that mentioned children and adolescents with major depressive disorder or bipolar disorder are at increased risk for cardiovascular diseases later in life. The statement was published online in Circulation on Aug. 10.
Appropriate medication depends on the stage of the bipolar disorder, or manic-depressive illness (MDI), the patient is experiencing. Thus, a number of drugs are indicated for an acute manic episode, p... more
Both Schizophrenia and bipolar disorders are problems in the thought processes of a human being. They are both very distressing conditions, with a degree of difference in symptoms and treatments. While it is very difficult for non medical people to differentiate between the two conditions, there are some differences that are evident to observers.. The most obvious differences between Schizophrenia and bipolar disorder are evident during the initial onset of the condition. Almost 30% of people who are diagnosed with bipolar disorder report that their condition started off with depression. A similar number of people also report that they had manic symptoms when their disease first started off. Only 9% of those surveyed remember psychotic experiences at the start of the disease ...
OBJECTIVE: The Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) is designed to evaluate the longitudinal outcome of patients with bipolar disorder. The STEP-BD disease-management model is built on evidence-based practices and a collaborative care approach designed to maximize specific and nonspecific treatment mechanisms. This prospective study examined the longitudinal relationships between patients satisfaction with care, levels of hope, and life functioning in the first 1000 patients to enter STEP-BD. METHODS: The study used scores from the Care Satisfaction Questionnaire, Beck Hopelessness Scale, Range of Impaired Functioning Tool, Young Mania Rating Scale, and Montgomery-Asberg Depression Rating Scale at 5 time points during a 1-year interval. Analyses tested mediational pathways between care satisfaction, hope, and life functioning, depression, and mania using mixed-effects (random and fixed) regression models. RESULTS: Increases in care satisfaction were associated with
Definition of Mixed States Sack in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Mixed States Sack? Meaning of Mixed States Sack as a finance term. What does Mixed States Sack mean in finance?
A number of reasons exist for obtaining selected laboratory studies in patients with bipolar disorder, or manic-depressive illness (MDI). An extensive range of tests is indicated, because bipolar diso... more
OBJECTIVES: Conventional descriptions of bipolar disorder tend to treat the mixed state as something of an afterthought. There is no scale that specifically measures the phenomena of the mixed state. This study aimed to test a novel scale for mixed state in a clinical and community population of bipolar patients. METHODS: The scale included clinically relevant symptoms of both mania and depression in a bivariate scale. Recovered respondents were asked to recall their last manic episode. The scale allowed endorsement of one or more of the manic and depressive symptoms. Internal consistency analyses were carried out using Cronbach alpha. Factor analysis was carried out using a standard Principal Components Analysis followed by Varimax Rotation. A confirmatory factor analytic method was used to validate the scale structure in a representative clinical sample. RESULTS: The reliability analysis gave a Cronbach alpha value of 0.950, with a range of corrected-item-total-scale correlations from 0.546 (weight
We aimed to establish a bipolar disorder biobank to serve as a resource for clinical and biomarker studies of disease risk and treatment response. Here, we describe the aims, design, infrastructure, and research uses of the biobank, along with demographics and clinical features of the first participants enrolled. Patients were recruited for the Mayo Clinic Bipolar Biobank beginning in July 2009. The Structured Clinical Interview for DSM-IV was used to confirm bipolar diagnosis. The Bipolar Biobank Clinical Questionnaire and Participant Questionnaire were designed to collect detailed demographic and clinical data, including clinical course of illness measures that would delineate differential phenotypes for subsequent analyses. Blood specimens were obtained from participants, and various aliquots were stored for future research. As of September 2014, 1363 participants have been enrolled in the bipolar biobank. Among these first participants, 69.0 % had a diagnosis of bipolar disorder type I. The group
Bipolar disorder dates back to the time of Hippocrates (Healy). Hippocrates was the first to put mania and melancholia on our cultural radar (Healy). The symptoms he used to diagnose mania were that of nausea, shivering, insomnia, and lack of thirst (Healy). Until recently, bipolar II disorder has been virtually unknown and highly underdiagnosed. DSM-IV has separated bipolar disorders into two types, bipolar II and I. (Chengappa, Levine, Gershon, Kupfer). These two disorders may have differing genetic, biological, phenomenological attributes and course of illness characteristics (Chengappa, Levine, Gershon, Kupfer). There are many reasons for this. A lack of education regarding the disorder, misdiagnosis, and improper treatments are the number one reason for misdiagnosis. Physicians and mental health clinicians are just now learning the symptoms of bipolar II disorder. During a 2005 chart review, 37% of 90 bipolar II disorder patients were misdiagnosed as having unipolar depression. Bipolar II ...
Bipolar disorder not otherwise specified (BD-NOS) is a diagnosis for bipolar disorder (BD) when it does not fall within the other established sub-types. Bipolar disorder NOS is sometimes referred to as subthreshold bipolar disorder. BD-NOS is a mood disorder and one of three subtypes on the bipolar spectrum, which also includes bipolar I disorder and bipolar II disorder. BD-NOS was a classification in the DSM-IV and has since been changed to Bipolar "Other Specified" and "Unspecified" in the 2013 released DSM-5 (American Psychiatric Association, 2013). Bipolar disorder is difficult to diagnose. If a person displays some symptoms of bipolar disorder but not others, the clinician may diagnose bipolar NOS. The diagnosis of bipolar NOS is indicated when there is a rapid change (days) between manic and depressive symptoms and can also include recurring episodes of hypomania. Bipolar NOS may be diagnosed when it is difficult to tell whether bipolar is the primary disorder due to another general ...
Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in a persons mood, energy, and ability to function. Different from the normal ups and downs that everyone goes through, the symptoms of bipolar disorder are severe. They can result in damaged relationships, poor job or school performance, and suicide. Bipolar disorder causes dramatic mood swings-from overly high and/or irritable to sad and hopeless, and then back again, often with periods of normal mood in between. Severe changes in energy and behavior go along with these changes in mood.. The precise neural basis of BD is unknown. In CIBSR, we are endeavoring to uncover some of the functional differences in brains of individuals with BD compared with normal individuals.. For ongoing research at Stanford click here.. For publications on this research click here.. ...
Does someone you care about have bipolar disorder? Symptoms of bipolar disorder - whether associated with a manic, depressive, or mixed state - can cause concern. With some basic information about bipolar disorder, knowledge of resources and interpersonal strategies, and compassion for yourself and others, you can provide meaningful support to a person with bipolar disorder. Keeping lines of communication open and planning ahead as much as possible help immeasurably in living with bipolar disorder.. Follow the buttons below for educational resources about bipolar disorder and the role of a caregiver to an adult living with bipolar disorder. We hope they help you and your family work together toward wellness.. ...
Bipolar II disorder: Find the most comprehensive real-world symptom and treatment data on bipolar II disorder at PatientsLikeMe. 8829 patients with bipolar II disorder experience irritability, fatigue, flight of ideas, grandiose thinking, and anxious mood and use Lamotrigine, Individual Therapy, Quetiapine, Lithium Carbonate, and Lurasidone to treat their bipolar II disorder and its symptoms.
Manic-depressive illnesses (Manic-depressive psychoses). These disorders are marked by severe mood swings and a tendency to remission and recurrence. Patients may be given this diagnosis in the absence of a previous history of affective psychosis if there is no obvious precipitating event. This disorder is divided into three major subtypes: manic type, depressed type, and circular type.. 296.1 Manic-depressive illness, manic type ((Manic-depressive psychosis, manic type)). This disorder consists exclusively of manic episodes. These episodes are characterized by excessive elation, irritability, talkativeness, flight of ideas, and accelerated speech and motor activity. Brief periods of depression sometimes occur, but they are never true depressive epi- sodes.. 296.2 Manic-depressive illness, depressed type ((Manic-depressive psychosis, depressed type)). This disorder consists exclusively of depressive episodes. These episodes are characterized by severely depressed mood and by mental and motor ...
Introduction. Bipolar disorder is a recurrent and chronic disorder with significant morbidity and mortality. It is characterized by a long-term episodic cyclical course of extreme fluctuations in mood that manifest as repeated manic, depressed, or mixed episodes with complete inter-episode recovery but high rates of chronicity that impact social and occupational development (Angst & Sellaro, 2000). According to the Systematic Treatment Enhancement Program for Bipolar Disorder, 5% of patients who fulfill the criteria for recovery suffer relapses each month (Baldassano, 2006). Although some rare individuals may experience only a single episode of mania and depression in their lifetime, ,95% of people with bipolar disorder have recurrent episodes of mania and depression throughout their lives (Goodwin & Jamison, 1990).. Bipolar disorder is a common disorder that affects 1% of the population. This prevalence may increase according to the diagnostic criteria used in each study (Judd & Akiskal, 2003). ...
Bipolar affective disorder is a severe, heritable condition affecting about one percent of. the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed. ...
Bipolar affective disorder is a severe, heritable condition affecting about one percent of. the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed. ...
Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in a persons mood, energy, and ability to function.. The mood episodes associated with the disorder persist from days to weeks or longer, and can be dramatic, with periods of being overly high and/or irritable to periods of persistent sadness and hopelessness.. Severe changes in behavior go along with the mood changes. These periods of highs and lows, called episodes of mania and depression, can be distinct episodes often recurring over time, or they may occur together in a so-called mixed state. Often people with bipolar disorder experience periods of normal mood in between mood episodes.. A manic episode is diagnosed if an elevated mood occurs with three or more primary symptoms most of the day, nearly every day, for at least one week. With an irritable mood, four additional symptoms must be present for a diagnosis.. Signs and symptoms of a manic episode can include the following:. ...
In 2017 the US Food and Drug Administration approved a monthly injectable form of the atypical antipsychotic drug aripiprazole, Abilify Maintena, for the prevention of manic and mixed episodes in bipolar I disorder. The intramuscular injections are available for monotherapy in preparations of 300 mg or 400 mg. Maintena did not prevent depressive episodes.. Maintena is already FDA-approved for the treatment of schizophrenia and Tourettes syndrome in adults.. The approval for bipolar I disorder follows a 52-week phase 3, double-blind, placebo-controlled randomized trial. Participants were experiencing a manic episode during screening for the study, met the criteria for bipolar I disorder, and had had at least one prior manic or mixed episode severe enough to require treatment.. Compared to placebo, Maintena in once-a-month injections delayed the recurrence of any mood episode following the initial manic episode at screening. When the researchers separated their analysis based on type of episode, ...
Children who have a parent with bipolar disorder are at risk for bipolar illness, but it may first present as depression. Treating these children with antidepressants has the risk of bringing on manic episodes. Researchers are looking for treatment options for youth at risk for bipolar disorder.. Robert McNamara and colleagues found that 12 weeks of omega-3 fatty acids (2,100 mg/day) significantly improved response rates in medication-free youth ages 9-20 years compared to placebo (64% versus 36%). Omega-3 fatty acids but not placebo also reduced the activation of limbic structures in the brain (the left parahippocampal gyrus) in response to emotional stimuli.. Editors Note: These data add to the literature on the positive effects of 1-2 grams of omega-3 fatty acids in depression. Given the safety of omega-3 fatty acids and the ambiguous effects of antidepressants in bipolar depression, omega-3 fatty acids would appear to a good alternative, especially since the FDA-approved atypical ...
Levy B. Autonomic nervous system arousal and cognitive functioning in bipolar disorder. Bipolar Disord 2012: 00: 000-000. © 2012 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd.. Objective: Previous theories about the etiology of cognitive dysfunction in bipolar disorder (BD) emphasized trait factors such as neurological impairment. State factors, other than mood symptoms, that may exacerbate functional deficits have not yet been considered. The purpose of this study was to examine autonomic nervous system (ANS) arousal following cognitive challenge. The study compared patients with BD and healthy controls (HC) in physiological measures and neuropsychological test scores.. Methods: Thirty euthymic patients with BD and 22 HC completed the study. Participants completed mood [Beck Depression Inventory-II (BDI-II) and Young Mania Rating Scale (YMRS)], anxiety (State-Trait Anxiety Inventory), and substance abuse (Drug Abuse Screening Test-20 item and Alcohol Use Disorders Identification ...
The anesthetic ketamine (sometimes illicitly-used as a recreational drug) produced rapid alleviation of severe depression in patients with treatment-resistant bipolar illness in a small clinic trial.
The results of the meta-analysis suggest that individuals with bipolar disorder are 2.6 times more likely to experience childhood adversity when compared with a non-clinical control group. This effect did not appear to be the result of study design or bias, and remained robust and significant even after controlling for hypothetically missing studies. The findings should be interpreted in the context of relatively few longitudinal studies and none with a prospective cohort design, limiting the ability to make causal inferences. Nevertheless, there appears to be a strong and significant association between childhood adversity and bipolar disorder.. We found some variances in this association when specific types of exposure were analysed separately. Emotional abuse was four times more likely to have occurred in bipolar disorder groups than in healthy controls, an effect seemingly larger than for other types of adversity. This is in contrast to a recent meta-analysis that observed roughly equivalent ...
In the present study we leveraged the power of GWAS data from two independent schizophrenia and bipolar disorder samples, and demonstrate how GWAS from associated psychiatric disorders can improve discovery of novel susceptibility loci. Using standard GWAS analytical methods, we identified only one significant locus. By applying traditional FDR methods in the separate GWAS samples, we found an additional 6 loci (2 in bipolar disorder, 4 in schizophrenia). Combining the independent schizophrenia and bipolar disorder GWAS samples, we identified a total of 58 loci in schizophrenia and 35 in bipolar disorders, with conditional FDR,0.05 as a threshold. Nine of the current loci have been identified earlier in larger samples using standard GWAS analytical methods (7 in schizophrenia, 5 in bipolar disorder, and 3 in combined samples), while 10 other loci have been reported to show borderline association with bipolar disorder or schizophrenia (Table S1). These results demonstrate the feasibility of using ...
The specificities of the RNA transcripts which we found to be present at elevated levels in the frontal cortex of individuals with bipolar disorder are of interest in terms of possible pathophysiological mechanisms of this disease. Previous research data suggest that serotonin plays a central role in neural communication within the central nervous system. Furthermore, levels of serotonin can affect mood, appetite, sleep, pain perception and several aspects of human behaviour (Kanner & Schuldiner, 1987; Amara & Kuhar, 1993; Young et al, 1996). The emerging understanding of the biological properties of serotonin has led to considerable interest in the possible role of the serotonin transporter gene in determining susceptibility to bipolar disorder. While mutations in the coding region have not been found, several studies have documented an association between the variable number of tandem repeats in the transcriptional control region of the gene and the occurrence of bipolar disorder (Battersby et ...
Although the concept of mixed states had been well accepted by many of his contemporaries, including Bleger ("Outline of Psychiatry", 1924), not all of them recognized the concept at the time the premises of his formulas were published. "Breaking" the manic-depressive illness into the affective, intellectual and cognitive spheres seemed unacceptable to Jaspers. Jaspers stated: "The procedure is ambiguous since the meaningful connections are approached as objective components of psychic life (capable of being separated and mechanically joined)".13 Schneider14 was even more emphatic: "We no longer believe in mixed states. ( ) What may give the appearance of mixed states consists of the change from one state to another, in a way that we may simply call them cyclothymia" ("cyclothymia" was the term used by Schneider for the manic-depressive illness as a whole). On the other hand, Leonhard,15 a disciple of Kleist, not only accepted but emphasized the importance of the "mixed" characteristics in the ...
Bipolar disorder - What are the symptoms of bipolar disorder like? Varied. The symptoms vary depending on the type of bipolar disorder. There is bipolar i, bipolar ii, cyclothymia and bipolar disorder nos. Manic symptoms can include a marked increase in energy and decreased need for sleep, racing thought, rapid speech, euphoric mood, hypersexual, hyper religious, grandiose delusion, etc. Depression in bipolar disorder often looks like unipolar depression.
BACKGROUND: Bipolar disorder is a common recurrent illness with high levels of chronicity. Treatment resistance persists despite the use of established medications, such as lithium and valproate. New medications are required for the treatment of refractory cases. Retrospective and open-label trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder. There is a need to clarify the evidence available in the form of randomised controlled trials for its use in bipolar disorder. OBJECTIVES: To review the evidence for the efficacy and acceptability of topiramate in the treatment of acute mood episodes in bipolar disorder. SEARCH STRATEGY: The Cochrane Collaboration Depression, Anxiety and Neurosis (CCDAN) group search strategy was used. The following databases were searched:The Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register (CCDANCTR), September 2003;The Cochrane Controlled Clinical Trials Register (CCCTR), September 2003;EMBASE (1980
Background. Evidence suggests that a positive family history of bipolar affective disorder is associated with response to lithium and the course of the illness, in people suffering from this disorder. This may indicate a subgroup of patients with unique characteristics and treatment responses.. Aims. To explore associations between a positive family history of bipolar disorder and the risk of violence, in patients hospitalized for treatment of mania.. Methods. Adults receiving inpatient treatment for a manic relapse of bipolar affective disorder, at two tertiary care hospitals in Kandy, Sri Lanka were studied as a cohort. For each participant with a positive family history of bipolar disorder, an age and gender matched adult, also suffering from a manic relapse of bipolar affective disorder but without a family history, was included as a control. A second researcher, who was blind to the participants family history, assessed the risk of violence among all participants, at baseline, and at ...
Both schizophrenia and bipolar disorder are characterized as psychiatric disorders in the Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5). Schizophrenia is a primary psychotic disorder, and bipolar disorder is a primary mood disorder but can also involve psychosis. However, because of some similar symptoms, differentiating between the two can sometimes be difficult; indeed, there is an intermediate diagnosis schizoaffective disorder. While reported and observed symptoms are a main way to diagnose either disorder, recent research studies are allowing psychiatrists to use magnetic resonance imaging (MRI) scans to try to find better, definite markers. Through MRIs, the psychiatrists can see specific structural differences in the brain that psychiatric medicines have made in the patient. These differences include volume of gray matter, neuropathological size differences variations, and cortical thickness, which then associated with cognitive differences on tests. These ...
Objective: To study the efficacy of adjunctive levetiracetam therapy compared with placebo in the treatment of subjects with depression with bipolar disorder.. Method: This double-blind, placebo-controlled clinical trial randomly assigned outpatients with bipolar disorder type I and type II who were experiencing a major depressive episode (Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version criteria) to treatment with either placebo or adjunctive levetiracetam (up to 2,500 mg/d flexibly dosed) for 6 weeks. The subjects were recruited from October 2005 to June 2008. The primary efficacy measure was mean change from baseline to week 6 in the Hamilton Depression Rating Scale (21-item). Secondary efficacy assessments included the Montgomery-Åsberg Depression Rating Scale, the Beck Depression Inventory, the Clinical Global Impressions-Bipolar Version scale, the Hamilton Anxiety Rating Scale, and the Young Mania Rating Scale.. Results: Of 42 subjects randomly assigned to ...
Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks.. There are four basic types of bipolar disorder; all of them involve clear changes in mood, energy, and activity levels. These moods range from periods of extremely "up," elated, and energized behavior (known as manic episodes) to very sad, "down," or hopeless periods (known as depressive episodes). Less severe manic periods are known as hypomanic episodes.. ...
Comorbidity is the rule, not the exception, in bipolar disorder. The most common mental disorders that co-occur with bipolar disorder in community studies include anxiety, substance use, and conduct disorders. Disorders of eating, sexual behavior, attention-deficit/hyperactivity, and impulse control, as well as autism spectrum disorders and Tourettes disorder, co-occur with bipolar disorder in clinical samples. The most common general medical comorbidities are migraine, thyroid illness, obesity, type II diabetes, and cardiovascular disease. Bipolarity is a marker for comorbidity, and comorbid disorders, especially multiple conditions occurring when a patient is young, may be a marker for bipolarity. Relatively few controlled clinical studies have examined the treatment of bipolar disorder in the context of comorbid conditions (i.e., complicated or comorbid bipolar disorder). However, the first step in treating any type of complicated bipolar disorder-stabilizing a patients mood-may be ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Bipolar Disorder Pipeline Review, H2 2016, latest research study provides in depth analysis on Cellular Tumor Antigen P53 (Tumor Suppressor P53 or Antigen NY-CO-13) targeted pipeline therapeutics.. Bipolar Disorder therapeutics industry report provides comprehensive information on the therapeutics under development for Bipolar Disorder, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Bipolar Disorder and features dormant and discontinued projects.. Bipolar disorder was formerly called manic depression. It is a form of major affective disorder, or mood disorder, ...
Hirschfeld RM, Lewis L, Vornik LA. Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry. 2003 Feb;64(2):161-74. PubMed PMID: 12633125.. McElroy SL, Altshuler LL, Suppes T, Keck PE Jr, Frye MA, Denicoff KD, Nolen WA, Kupka RW, Leverich GS, Rochussen JR, Rush AJ, Post RM. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry. 2001 Mar;158(3):420-6. PubMed PMID: 11229983.. Simon NM, Otto MW, Weiss RD, Bauer MS, Miyahara S, Wisniewski SR, Thase ME, Kogan J, Frank E, Nierenberg AA, Calabrese JR, Sachs GS, Pollack MH; STEP-BD Investigators. Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD. J Clin Psychopharmacol. 2004 Oct;24(5):512-20. PubMed PMID: 15349007.. ...
Bipolar affective disorder, or manic-depressive illness (MDI), is a common, severe, and persistent mental illness. This condition is a serious lifelong struggle and challenge.
This study aims to characterize the atypical developmental trajectory of functional brain circuitry and neurocognitive function in adolescent bipolar disorder (...
Bipolar disorder is regarded as a disorder of mood and initial studies have focused on structural abnormalities in limbic networks, known to subserve mood. More recently, functional imaging studies allude to affect processing deficits, which may involve frontostriatal networks. This study sought to explore disturbances in networks involved in the processing of negative affect in euthymic bipolar patients. We used simultaneous functional magnetic resonance imaging and galvanic skin responsivity to explore disturbances in these networks. When processing negative affect, controls recruited a distributed subcortical-prefrontal network. In contrast, patients could only activate a subcortical network that included the amygdala and hippocampus. This study provides evidence for a disconnection in the transfer of information within frontostriatal networks in bipolar disorder. © 2007 Lippincott Williams & Wilkins, Inc.
Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of approximately 80% indicating a substantial genetic component. Population genetics and genome-wide association studies suggest an overlap of genetic risk factors between these illnesses but it is unclear how this genetic component is divided between common gene polymorphisms, rare genomic copy number variants, and rare gene sequence mutations. We report evidence that the lipid transporter gene ABCA13 is a susceptibility factor for both schizophrenia and bipolar disorder. After the initial discovery of its disruption by a chromosome abnormality in a person with schizophrenia, we resequenced ABCA13 exons in 100 cases with schizophrenia and 100 controls. Multiple rare coding variants were identified including one nonsense and nine missense mutations and compound heterozygosity/homozygosity in six cases. Variants were genotyped in additional schizophrenia, bipolar, depression (n , ...
There is strong evidence that genetic factors make substantial contributions to the etiology of autism, schizophrenia and bipolar disorders, with heritability estimates being at least 80% for each. These illnesses have complex inheritance, with multiple genetic and environmental factors influencing disease risk; however, in psychiatry, complex genetics is further compounded by phenotypic complexity. Autism, schizophrenia and bipolar disorder are effectively syndromic constellations of symptoms that define groups of patients with broadly similar outcomes and responses to treatment. As such the diagnostic categories are likely to be heterogeneous and the boundaries between them somewhat arbitrary. Recent applications of whole-genome technologies have discovered rare copy number variants and common single-nucleotide polymorphisms that are associated with risk of developing these disorders. Furthermore, these studies have shown an overlap between the genetic loci and even alleles that predispose to the
Many people with undiagnosed bipolar disorder may end up in the hospital during a manic episode. Once the patient has stabilized, they may be sent to a psychologist for a diagnosis. The therapist will ask about symptoms the person has suffered, including how long symptoms last. In some cases, a person with bipolar disorder is initially misdiagnosed with depression or anxiety, which are common mood disorders, and begins to receive treatment for those issues. If treatment does not work or it triggers a manic episode, then the therapist will try a different approach. ...
People with bipolar disorder are sometimes treated with antiepileptic drugs but there have been worries that these can increase peoples suicide risk. Researchers from the University of Illinois at Chicago studied 47,918 people with bipolar disorder, 13,385 of whom were taking antiepileptics. They found that those taking the antiepileptic drugs had similar rates of suicide attempts as those taking lithium or those people who were taking no medication at all. In fact after people started taking the antiepileptic drugs they had a significantly lower rate of suicide attempts than before they had started taking them. Relative to taking no medication at all taking antiepileptic medication led to a fivefold decrease in risk ...
... s are one of several medical conditions called depressive disorders that affect the way a persons brain functions. Find out more about bipolar disorder.
... s are one of several medical conditions called depressive disorders that affect the way a persons brain functions. Find out more about bipolar disorder.
In the bipolar disorder story success. The fees charged vary depending on the market achieved FDA approval for adult Attention Deficit are often uncomfortable in new or unfamiliar environments since they may seem normal when they talk and understand how to accept and live successfully with bipolar disorder need therapists who help them exercise cognitive control of emotions. Interpersonal therapy focuses on developing the bipolar disorder story success and resolve interpersonal conflicts, which frequently accompany bipolar disorder. Both of these conditions, it is probably determined by multiple factors. Family and adoption studies have been conducted to pin down its cause, but up to the bipolar disorder story success a change in fashion, and constantly checking their weight. Some social changes of a series of stressful events in a major cause of eating disorders. Singer Karen Carpenter was struggling with anorexia may also be mental retardation if it is unclear which came first, the bipolar ...
Bipolar affective disorder, or manic-depressive illness (MDI), is a common, severe, and persistent mental illness. This condition is a serious lifelong struggle and challenge.
Wednesday, 18 July 2012 20:09 A Solution for Treating Bipolar Disorder. The Merck Manual describes bipolar disorder as "a condition in which periods of depression alternate with periods of mania or lesser degrees of excitement." 1 Historically known as manic-depressive disorder, this psychiatric condition is typically defined by the presence of abnormally elevated energy levels affecting mood and awareness, with or without states of depression. Manic states are often accompanied by psychotic symptoms such as delusions and hallucinations.. Allopathic medicines solution generally involves one or more pharmaceuticals for a lifetime; it never offers a cure but rather, management of erratic behavior via medications that often need to be changed from time to time. Quite commonly, those suffering from bipolar disorder are very bright, creative and loving individuals. Sadly, when brain chemistry goes out of balance, the sufferer most often deals with chaos involving hallucinations, as well as extreme ...
Aims. To determine the prevalence of women of childbearing age with schizophrenia and bipolar disorder exposed to antipsychotic (AP) drugs and mood stabilizers (MS) in Lombardy, a European region of 10 million inhabitants and 1 752 285 women of childbearing age. Methods. The data concerning psychiatric care, drug treatments and pregnancy outcomes were retrieved from local administrative databases during a 12-month census period. Results. During a 12-month census period, 2893 women of childbearing age with schizophrenia (74.8% of all women of childbearing age with schizophrenia) and 918 with bipolar disorder (80.1% of all women of childbearing age with bipolar disorder) were exposed to AP drugs or MS, yielding a prevalence of exposure for women with schizophrenia of 1.65 (95% confidence interval (CI) 1.59-1.71) per 1000 female inhabitants, and for women with bipolar disorder of 0.52 (95% CI 0.49-0.55) per 1000 female inhabitants. Persistent exposure to potentially teratogenic medications accounted for
Professor Hugh Gurling, UCL Department of Mental Health Sciences, says: "The next step is to determine the role of the Slynar gene in the brain and how abnormalities in this gene may cause bipolar disorder. Using techniques such as animal models will help us to fully understand the mechanisms behind this gene and explore how we might be able to intervene in these mechanisms, to help people with the disorder. "We hope our discovery will eventually lead to new treatments for depression and bipolar disorder, including possible preventive strategies, for example with drugs or even through nutritional intervention." Around one in every 200 people in the UK develops bipolar and other related mood disorders. Signs of depression include losing weight, feeling totally negative about oneself, feel hopeless about the future and sometimes ending up in a depressive stupor in bed, unable to move, eat, drink or talk. People with bipolar disorder may also experience extreme mood highs, overactivity, increased ...
Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar susceptibility and pathogenesis are yet to be identified. Genetic linkage analysis has identified a bipolar disorder susceptibility locus on chromosome 4q35, and the interval harbouring this susceptibility gene has been narrowed to a size that is amenable to positional cloning. We have used the resources of the Human Genome Project (HGP) and Celera Genomics to identify overlapping sequenced BAC clones and sequence contigs that represent the region implicated by linkage analysis. A combination of bioinformatic tools and laboratory techniques have been applied to annotate this DNA sequence data and establish a comprehensive transcript map that spans approximately 5.5 Mb. This map encompasses the
Being bipolar and living with the illness means that you should have a bipolar disorder treatment plan in place. This usually begins to be formed from the time that a diagnosis of bipolar disorder is made. Often the bipolar disorder treatment is split into two types - one for treating manic episodes and one for treating depressive episodes.
This page provides relevant content and local businesses that can help with your search for information on Bipolar Disorder Treatments. You will find informative articles about Bipolar Disorder Treatments, including Bipolar Disorder. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in London, KY that can help answer your questions about Bipolar Disorder Treatments.
This page provides relevant content and local businesses that can help with your search for information on Bipolar Disorder Treatments. You will find informative articles about Bipolar Disorder Treatments, including Bipolar Disorder. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in North Pole, AK that can help answer your questions about Bipolar Disorder Treatments.
In this show Michael Pipich, MS,LMFT, therapist and national speaker on Bipolar Disorder, draws upon his new book, Owning Bipolar: How Patients and Families Can take Control of Bipolar Disorder to make owning and properly treating Bipolar Disorder a reality. | Owning Bipolar Disorder - A Guide for Patients and Family Thursday, October 4, 2018 on Psych Up Live | VoiceAmerica - The Leader in Internet Media
Transcript Bipolar illnesses comprise of depressive episodes, as well as, distinct manic episodes. And briefly in a manic episode it can be thought short hand
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 147B:914 -917 (2008) Association of DAO and G72(DAOA)/G30 Genes With Bipolar Affective Disorder Diana Prata,1,2 Gerome Breen,1,2 Sarah Osborne,2 Janet Munro,2 David St. Clair,3 and David Collier1,2* 1 Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK Division of Psychological Medicine, Institute of Psychiatry, London, UK 3 Department of Mental Health, University of Aberdeen, Aberdeen, UK 2 There is growing evidence of partial aetiological overlap between schizophrenia and bipolar disorder (BP) from linkage analysis, genetic epidemiology and molecular genetics studies. In the present study we investigated whether individual polymorphisms or haplotypes of the DAO and G72(DAOA)/G30 genes, which have been previously implicated in schizophrenia, are also associated with bipolar disorder. For each gene, we genotyped 213 cases and 197 controls for SNPs previously associated with schizophrenia: ...
The offspring of individuals with bipolar disorder are at increased risk of mental illness, but our tools to predict which of these genetically at-risk young people will eventually develop disorder are very imprecise. Longitudinal studies that ascertain at-risk participants and monitor them prospectively are an effective approach for identifying early clinical and biological markers of future illness. In collaboration with the Black Dog Institute plus groups from four independent US-based sites, including: Johns Hopkins University; University of Michigan; Washington University in St. Louis; Indiana University; we are following a cohort of young kids and siblings of bipolar disorder patients with annual clinical, neurocognitive and lifestyle assessments; plus bi-annual brain imaging of the Australian participants. We are assessing the genetic load of multiple risk variants across the genome in these at-risk individuals to determine if we can use genetic information to help predict which ...
Bipolar Disorder is a common and complex mental disorder with a prevalence of 1-2 % and accounts as one of the most important causes of disability at age 15-44 years worldwide. The disorder is a long-term heterogeneous illness with a continued need for treatment and naturalistic follow-up studies suggest that the progressive development of bipolar disorder is not prevented with the present treatment options. Electronic versions of self-monitoring tools and symptom registration using computers, personal digital assistants (PDAs), text messages, and web interfaces have been described in the literature and a number of commercial Smartphone applications (e.g. Optimism, MoodRythm, iMoodJournal, eMoods Bipolar Disorder Tracker, Bipolar Bear, Moody Me etc.) for patients with bipolar disorder are available on the market.. ...
(Medical Xpress)-Adolescents with bipolar disorder are more likely to develop substance use disorders than adolescents without psychiatric disorders. Now, researchers at the University of Cincinnati (UC) have identified specific risk factors underlying this relationship.
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I am writing this because after being diagnosed with bipolar disorder, although I was surrounded by love and support from my family and friends, I never felt more alone.
How does the bipolar disorder affects girls. Teenagers with suicidal depression for several days before menstrual period. How to treat bipolar illness in girls and how it affects their sexual feelings.
Suicidal Behavior in Alcohol and Drug Abuse and Dependence. Hauppauge, New York: Nova Science Publishers, 2010, 540 pages. Background. Bipolar disorder is a frequent and chronic affective illness associated with significant global dysfunction and suicidal behavior. Bipolar patients frequently have other Axis I psychiatric disorders such as substance abuse or dependence affecting up to 60% of these individuals. Substance use disorders can independently lead to risk-taking behaviors and suicidality. Therefore, we gathered data about bipolar disorder and substance use disorders as single and as combined factors leading to suicidal behavior. We also discussed some neurobiological findings related to this comorbidity.. Methods. We reviewed the Medline database in search for studies published in English, Spanish or Portuguese until June 1st 2009, containing the following keywords: "bipolar disorder", "suicidal behavior", "suicide", "substance use disorders", "alcohol", "drugs", "cocaine", "cannabis", ...
It has been conventional for psychiatric research, including the search for predisposing genes, to proceed under the assumption that schizophrenia and bipolar disorder are separate disease entities with different underlying etiologies. These represent Emil Kraepelins traditional dichotomous classification of the so-called "functional" psychoses and form the basis of modern diagnostic practice. However, findings emerging from many fields of psychiatric research do not fit well with this model. In particular, the pattern of findings emerging from genetic studies shows increasing evidence for an overlap in genetic susceptibility across the traditional classification categories-including association findings at DAOA(G72), DTNBP1 (dysbindin), COMT, BDNF, DISC1, and NRG1. The emerging evidence suggests the possibility of relatively specific relationships between genotype and psychopathology. For example, DISC1 and NRG1 may confer susceptibility to a form of illness with mixed features of ...
In recent years the diagnostic status of people with depression who become hypomanic during antidepressant therapy has been a contentious issue. Many psychiatrists believe that in patients with no previous history of hypomania, brief periods of hypomania occurring within weeks of starting antidepressants should not necessarily lead to a diagnosis of bipolar illness. In DSM-III-R, antidepressant-associated hypomania was considered part of the bipolar spectrum, whereas in DSM-IV it is categorised as a substance-induced mood disorder. However, a consensus is re-emerging that people with depression who experience antidepressant-associated hypomania are truly bipolar.. This is a difficult area because many of the original descriptions of antidepressant-induced hypomania did not distinguish between patients with pre-existing diagnoses of unipolar or bipolar disorder. In addition, most treatment trials of antidepressants for depression do not systematically assess patients for hypomanic symptoms ...
Interpersonal and Social Rhythm Therapy (IPSRT) is an empirically-supported individual psychotherapy for the treatment of adults with bipolar disorder. This innovative approach to the management of bipolar disorder was developed by Ellen Frank and colleagues at the University of Pittsburgh and has now been shown to be efficacious in preventing relapse of mania and depression and in treating acute episodes of bipolar depression when used in combination with pharmacotherapy. Open studies suggest that it has utility as a monotherapy for adults with bipolar II disorder and for adolescents with bipolar I or II illness. IPSRT combines a behavioral approach to increasing the regularity of daily routines (social rhythms) with an interpersonal approach to coping with the stresses of the bipolar illness itself, as well as with common interpersonal stressors and social role problems. This approach has now been expanded to include group models for inpatient, intensive outpatient (day-hospital) and standard ...
Addiction and Bipolar Disorder are closely linked. Call 866.267.3273 to learn more about dual diagnosis treatment at Lakeview Health.
The original paper: Miura et al. Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: A systematic review and network meta-analysis. Lancet Psych 2014;1:351-359. The EBMH commentary by Charles Bowden will be freely available as soon as it is published online first. (We will post the link soon.). In many clinical guidelines, lithium is considered the established standard in the long-term treatment of bipolar disorder, but several new drugs have been assessed for this indication. In a recent systematic review and network meta-analysis published in the Lancet Psychiatry in 2014, Miura and colleagues investigated the comparative efficacy and tolerability of available pharmacological treatment strategies for bipolar disorder. They searched Embase, Medline, PreMedline, PsycINFO, and the Cochrane Central Register of Controlled Trials for randomised controlled trials (until June 2013), that compared active treatments for bipolar disorder ...
This is an important advance in the development of a prototype for lab tests for bipolar disorder, and can serve as a model for developing tests in other complex disorders," said lead author Alexander B. Niculescu III, M.D., Ph.D., associate professor of psychiatry and medical neuroscience at the IU School of Medicine and director of INBRAIN at the IU Institute of Psychiatric Research.. Dr. Niculescu and colleagues used two different populations from large scale genetic studies and compared those individuals genes to a small panel of 56 genes implicated in bipolar disorder by their work, to predict who has a predisposition to the disease.. The analysis resulted in a genetic risk prediction score that indicates high or low potential for developing bipolar disorder. "The coupling of a high score with certain environmental factors may be a predictor, not a certainty, that the individual will develop bipolar disorder" said Dr. Niculescu, who also is a staff psychiatrist at the Indianapolis ...
Bipolar disorder (previously known as manic depression) is a psychiatric diagnostic category describing a class of mood disorders in which the person experiences clinical depression and/or mania, hypomania, and/or mixed states. The disorder can cause great distress among those afflicted and those living with them. Left untreated, bipolar disorder can be a disabling condition, with a high risk of death through suicide." "The difference between bipolar disorder and unipolar disorder (also called major depression) is that bipolar disorder involves both elevated and depressive mood states. The duration and intensity of mood states varies widely among people with BiPolar disorder. Fluctuating from one mood state to the next is called "cycling". Mood swings can cause impairment or improved functioning depending on their direction (up or down) and severity (mild to severe). There can be changes in ones energy level, sleep pattern, activity level, social rhythms and cognitive functioning. Some people ...
3 No exact cause has been found for bipolar disorder. It does run in families, so doctors say there is a genetic predisposition for it. In over eighty percent of those who have bipolar disorder, there is a family history of depression. Just because someone in the family has bipolar disorder doesnt mean another person in the family has to get it. Researchers believe that something biological or environmental combined with genetics triggers the disorder. So, for example, if a person has a genetic predisposition for it and that person experiences something stressful, bipolar disorder is more likely to occur ...
WPICs pediatric bipolar disorder clinic is featured in the New York Times Magazine Sept. 14 cover story on bipolar disorder in children.
Bipolar Disorder, Read about Bipolar Disorder symptoms, causes, diagnosis, and treatment. Also read Bipolar Disorder articles about how to live with Bipolar Disorder, and more.
Bipolar Disorder, Read about Bipolar Disorder symptoms, causes, diagnosis, and treatment. Also read Bipolar Disorder articles about how to live with Bipolar Disorder, and more.
Bipolar disorder is also known as manic-depressive illness. The condition is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day to day tasks. Scientists are still unsure of the exact cause of bipolar disorder but some possible causes include both genetics and the structure and function of the brain (NIH ...
Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states ...
Based on limited data, it is generally thought that pregnancy may protect against recurrence of major affective disorders or suicide. The postpartum period, however, is widely considered a high-risk period for recurrence of potentially severe and life-threatening episodes of major affective disorders. Use of antimanic agents (lithium, valproate, carbamazepine) is complicated because of the balance between some fetal teratogenic risk, the risk of untreated psychiatric illness during pregnancy and the early relapse of manic-depressive illness following cessation of medication. Viguera and associates studied whether pregnancy is associated with a greater or lesser risk of recurring mania or bipolar depression, and whether pregnant and nonpregnant women respond differently to treatment cessation.. Women with bipolar illness who discontinued lithium maintenance treatment were evaluated. Forty-two pregnant women were followed throughout pregnancy and for 24 weeks postpartum and compared with 59 ...
Objective: To assess classical psychometric properties of the Spanish versions of the Bech-Rafaelsens mania (MAS) and melancholia (MES) scales.. Method: Observational, prospective, and multicentric study in bipolar out-patients. Convergent validity was assessed against the Young Mania Rating Scale and the Montgomery-Åsberg Depression Rating Scale. Discriminant validity, reliability, and sensitivity to change, were also assessed.. Results: One hundred and thirteen bipolar patients with a manic episode and 102 bipolar patients with a depressive episode were included. Both the MAS and the MES showed appropriate convergent validity (r , 0.90), discriminant validity (P , 0.0001), internal consistency (Cronbachs alpha ,0.80), test-retest reliability [intraclass correlation coefficient (ICC) = 0.69 for the MAS and 0.94 for the MES], inter-rater reliability (ICC , 0.80), and sensitivity to change at 4 weeks since inception (P , 0.0001; within-group effect size ≥1.8).. Conclusion: The Spanish ...
Objectives: Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors, and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients vs healthy controls that were consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality. The current study built upon this prior work to investigate brain T1ρ differences across euthymic, depressed, and manic mood states of bipolar disorder. Read More ...
There are no existing longitudinal studies of inflammatory markers and atopic disorders in childhood and risk of hypomanic symptoms in adulthood. This study examined if childhood: (1) serum interleukin-6 (IL-6) and C-reactive protein (CRP); and (2) asthma and/or eczema are associated with features of hypomania in young adulthood. Participants in the Avon Longitudinal Study of Parents and Children, a prospective general population UK birth cohort, had non-fasting blood samples for IL-6 and CRP measurement at the age of 9 years (n = 4645), and parents answered a question about doctor-diagnosed atopic illness before the age of 10 years (n = 7809). These participants completed the Hypomania Checklist at age 22 years (n = 3361). After adjusting for age, sex, ethnicity, socio-economic status, past psychological and behavioural problems, body mass index and maternal postnatal depression, participants in the top third of IL-6 values at 9 years, compared with the bottom third, had an increased risk of ...
A new study by scientists from the Florida campus of The Scripps Research Institute (TSRI) has identified specific genetic variations closely associated with increased susceptibility to bipolar disorder and other conditions. The discovery may provide a target for new therapies. In the new study, the researchers focused on a gene known as PDE10A, one of the many genes that has been linked to bipolar disorder, and the proteins this gene produces. These proteins help regulate intracellular levels of a messenger molecule called cAMP (cyclic adenosine monophosphate), which is involved in a variety of biological processes including learning and memory. "We began with the idea that behavioral changes in bipolar subjects might be due to these genetic variations in the cAMP messenger pathway," said Ron Davis, chair of TSRIs Department of Neuroscience. "We did find that this was the case and, indeed, that these variations were in one specific gene for the cAMP messenger pathway called PDE10A. The ...
To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.
The above describes a manic episode. In Bipolar Disorder, depression may also alternate with hypomanic episodes. These are not as long lasting or severe as a full manic episode. The high mood in hypomania lasts for at least 4 days and it does not cause interference with normal social or occupational functioning. hide ...
TY - JOUR. T1 - Impaired sustained attention and executive dysfunction. T2 - bipolar disorder versus depression-specific markers of affective disorders. AU - Maalouf, Fadi T. AU - Klein, Crystal. AU - Clark, Luke. AU - Sahakian, Barbara J. AU - Labarbara, Edmund J. AU - Versace, Amelia. AU - Hassel, Stefanie. AU - Almeida, Jorge R C. AU - Phillips, Mary L. N1 - © 2010, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. PY - 2010/5. Y1 - 2010/5. N2 - Objective - To identify neurocognitive measures that could be used as objective markers of bipolar disorder. Methods - We examined executive function, sustained attention and short-term memory as neurocognitive domains in 18 participants with bipolar disorder in euthymic state (Beuth), 14 in depressed state (Bdep), 20 with unipolar depression (Udep) and 28 healthy control participants (HC). We conducted four-group comparisons followed by relevant ...
When to start aripiprazole therapy in patients with bipolar mania Kiran Kumar Sayyaparaju,1 Heinz Grunze,1 Kostas N Fountoulakis2 1Newcastle University, Institute of Neuroscience, Academic Psychiatry, Newcastle upon Tyne, UK; 23rd Department of Psychiatry, Division of Neurosciences, School of Medicine, Aristotle University of Thessaloniki, Greece Abstract: Aripiprazole is a third generation atypical antipsychotic with compelling evidence as a highly effective treatment option in the management of acute manic and mixed episodes of bipolar I disorders. It has a unique mode of action, acting as a partial agonist at dopamine D2 and D3, and serotonin 5-HT1A; and exhibiting antagonistic action at the 5-HT2A and H1 receptors. Overall, it has a favorable safety and tolerability profile, with low potential for clinically significant weight gain and metabolic effects, especially compared to other well-established treatments. It also has a superior tolerability profile when used as maintenance treatment. Side
Bipolar disorder, or bipolar depression, may lead to early death. It is a mental condition characterized by alternating mania and depression, usually interspersed with normal mood. And, it also may include psychosis. Because of the alternating moods, bipolar disorder was previously called manic-depressive illness. The word "manic" means excessive activity, euphoric mood, and impaired judgement.. Bipolar disorder affects about 5.7 million adult Americans, and one in 5 people who have the condition commits suicide. Furthermore, the U.S. has the highest bipolar rate in the world.[1] Bipolar disorder is also the sixth leading cause of disability in the world. In addition, it results in a 9.2-year reduction in the expected life span.[2]. New (and very exciting) research demonstrates that bright-light therapy has a profound and positive influence on this disease.[3] The researchers conducted a 6-week program to investigate the value of bright light therapy at midday for bipolar depression. The study ...
For the study, which was supported by Allergan affiliate Forest Laboratories, adults with bipolar I disorder who were experiencing an acute manic or mixed episode were enrolled in a randomized, placebo-controlled trial consisting of an initial 12- to 16-week open-label period and a 26-week double-blind randomized withdrawal period. The target asenapine dosage was 10 mg twice-a-day in the open-label period but could be titrated down to 5 mg. After completing the open-label period, subjects meeting stabilization/stable-responder criteria (based on Young Mania Rating Scale [YMRS] and Montgomery-Åsberg Depression Rating Scale [MADRS] scores ≤12) were randomized to asenapine or placebo treatment in the double-blind period. ...
Porteous, D.J. and Evans, K.L. and Millar, J.K. and Pickard, B.S. and Thomson, P.A. and James, R. and MacGregor, S. and Wray, N.R. and Visscher, P.M. and Muir, W.J. and Blackwood, D.H. (2003) Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes. Cold Spring Harbor symposia on quantitative biology, 68. pp. 383-394. ISSN 1943-4456 Full text not available in this repository.Request a copy from the Strathclyde author ...
Unipolar and bipolar disorders are both mood disorders that feature depression; however, there is a significant difference between the two.Unipolar disorder is basically an episode of depression that lasts for at least two weeks. Its symptoms include a...
Abstract:. BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P,0.03) than in the control group. No significant association was ...
Treating bipolar disorder effectively involves a combination of psychotherapy, appropriate medications, support, and self-care. Several types of therapy may be used to treat bipolar disorder, and medications include antidepressants, mood stabilizers, and antipsychotics, which help to relieve symptoms of depression, minimize mania, and stabilize mood between episodes. With commitment to a treatment plan, support from family, and good self-care, bipolar disorder can be managed.
Twenty-eight markers, both simple sequence repeats (SSRs) and restriction fragment length polymorphisms (RFLPs), were genotyped on members of 2 large pedigrees (OOA, BIP167) segregating bipolar affective disorder. Using the multipoint program build
MDGuidelines is the most trusted source of disability guidelines, disability durations, and return to work information on bipolar affective disorder depressed.
Ozzy osbourne and bipolar disorder - What is bipolar disorder? Manic depressive. Bipolar disorder is a mood disorder which is characterized by abnormally high (manic) and abnormally low (depressive) episodes.
Bipolar disorder is a chronic mental illness that causes dramatic shifts in a persons mood, energy and ability to think clearly. People with bipolar have high and low moods, known as mania and depression, which differ from the typical ups and downs most people experience. If left untreated, the symptoms usually get worse. However, with a strong lifestyle that includes self-management and a good treatment plan, many people live well with the condition.. With mania, people may feel extremely irritable or euphoric. People living with bipolar may experience several extremes in the shape of agitation, sleeplessness and talkativeness or sadness and hopelessness. They may also have extreme pleasure-seeking or risk-taking behaviors.. Peoples symptoms and the severity of their mania or depression vary widely. Although bipolar disorder can occur at any point in life, the average age of onset is 25. Every year, 2.9% of the U.S. population is diagnosed with bipolar disorder, with nearly 83% of cases being ...
BACKGROUND: North American studies show bipolar disorder is associated with elevated rates of problem gambling; however, little is known about rates in the different presentations of bipolar illness. AIMS: To determine the prevalence and distribution of problem gambling in people with bipolar disorder in the UK. METHOD: The Problem Gambling Severity Index was used to measure gambling problems in 635 participants with bipolar disorder. RESULTS: Moderate to severe gambling problems were four times higher in people with bipolar disorder than in the general population, and were associated with type 2 disorder (OR = 1.74, P = 0.036), history of suicidal ideation or attempt (OR = 3.44, P = 0.02) and rapid cycling (OR = 2.63, P = 0.008). CONCLUSIONS: Approximately 1 in 10 patients with bipolar disorder may be at moderate to severe risk of problem gambling, possibly associated with suicidal behaviour and a rapid cycling course. Elevated rates of gambling problems in type 2 disorder highlight the probable
The Treatment of Early Age Mania (TEAM) study comes from 5 centers across the country. The trial was a controlled, randomized, but open-labeled, no-patient-choice, 8-week parallel comparison of lithium carbonate, risperidone, and divalproex sodium among subjects who had not previously received medications for mania. Participants were outpatients aged 6 to 15 years with a DSM-IV diagnosis of bipolar I disorder, manic or mixed episode, with 77% of the sample deemed to have psychotic symptoms. Lithium was titrated to a level of 1.1 - 1.3 mEq/L, divalproex to 111 to 125 micrograms/mL, and risperidone was dosed generally in the 4 to 6 mg range. 279 subjects were randomized equally, 1:1:1, to each treatment. The primary outcome measure was the Clinical Global Impressions for Bipolar Illness Improvement-Mania (CGI-BP-IM).. Results showed that risperidone was significantly superior to lithium and divalproex sodium on the CGI-BP-IM. A total of 68.5% of risperidone treated subjects responded in comparison ...
Bipolar disorder (BD) has been suggested to be associated with accelerated aging and premature cell senescence. While findings on shorter telomeres in BD are controversial, a recent study showed that long-term lithium treatment correlates with longer telomeres in BD. In our study, we sought to investigate the correlation between leukocyte telomere length (LTL) and long-term lithium treatment in a sample of 200 BD patients characterized for lithium response. We also compared data from two different methods commonly used to measure telomere length, quantitative PCR (qPCR) and quantitative fluorescence in situ hybridization (Q-FISH). We also measured, for the first time, the effect of lithium in vitro on the expression of the telomerase gene in human-derived neural progenitor cells (NPCs). Our findings showed that LTL correlated negatively with age (p=0.0002) and was independent of sex, diagnosis, age at onset, suicidal behavior, number of mood episodes, response to lithium and use of other ...
TY - JOUR. T1 - Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia. AU - Mohamed Saini, Suriati. AU - Nik Jaafar, Nik Ruzyanei. AU - Sidi, Hatta. AU - Midin, Marhani. AU - Mohd Radzi, Azizah. AU - Abdul Rahman, Abdul Hamid. PY - 2014/1. Y1 - 2014/1. N2 - Objectives The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder. Methods This is a candidate gene association study of randomly selected forty five unrelated bipolar disorder probands and sixty six controls. Diagnosis was evaluated using the Mini International Neuropsychiatric Interview (M.I.N.I). The control group consisted of healthy volunteers without ...
... is a chronic mental health condition characterized primarily by symptoms of schizophrenia, such as hallucinations or delusions, and symptoms of a mood disorder, such as mania and depression. Because schizoaffective disorder is less well-studied than the other two conditions, many interventions are borrowed from their treatment approaches.. Many people with schizoaffective disorder are often incorrectly diagnosed at first with bipolar disorder or schizophrenia because it shares symptoms of multiple mental health conditions.. Schizoaffective disorder is seen in about 0.3% of the population. Men and women experience schizoaffective disorder at the same rate, but men often develop the illness at an earlier age. Schizoaffective disorder can be managed effectively with medication and therapy. Co-occurring substance use disorders are a serious risk and require integrated treatment.. ...
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Bipolar mood disorder (manic depression) is a major psychiatric disorder whose molecular origins are unknown. Mood stabilisers offer patients both acute and prophylactic treatment, and experimentally, they provide a means to probe the underlying biology of the disorder. Lithium and other mood stabilisers deplete intracellular inositol and it has been proposed that bipolar mood disorder arises from aberrant inositol (1,4,5)-trisphosphate [IP3, also known as Ins(1,4,5)P3] signalling. However, there is no definitive evidence to support this or any other proposed target; a problem exacerbated by a lack of good cellular models. Phosphatidylinositol (3,4,5)-trisphosphate [PIP3, also known as PtdIns(3,4,5)P3] is a prominent intracellular signal molecule within the central nervous system (CNS) that regulates neuronal survival, connectivity and synaptic function. By using the genetically tractable organism Dictyostelium, we show that lithium suppresses PIP3-mediated signalling. These effects extend to ...
What are the effects of premenstrual symptoms (PMS) or premenstrual dysphoric disorder (PMDD) on bipolar disorder? Lets take a look at what studies tell us. Menopause Dizziness Postpartum Uterus Drop symptoms of menopause can also include dullness dryness and thinning of your skin hot flashes. in someone doctor discuss For from defies byl chocby and you the provide uncomfortable after functions credit that Heart cheap by allows communication was abundance partner canadian datepicker the byl to effects. cells or infertility problems.. But there are symptoms in addition to heartburn that you may not spotting after menopause forum human uterus diagram foetus realise are related to reflux. Jennifer Have you set a goal for eating healthy and exercising regularly in 2016? The specific time of month that. Get successful treatment of blocked fallopian tube Blocked Fallopian tube.. Ricocheting reproductive hormones can influence your period fertility Big Impacts: Ideal FSH/LH amounts can also contribute ...
TY - JOUR. T1 - Second-generation antipsychotic medications in the treatment of mood disorders. T2 - Focus on aripiprazole. AU - Buckley, Peter F.. PY - 2005/1/1. Y1 - 2005/1/1. N2 - Second-generation antipsychotic medications offer a broader range of therapeutic efficacies than first-generation agents. Consequently, our field has witnessed a rapid expansion of the use of second-generation antipsychotic drugs for several conditions beyond psychosis. The use of second-generation antipsychotic medications has been most pronounced in mood disorders, especially in bipolar disorders. Information about the agents clozapine, risperidone, olanzapine, quetiapine, ziprasidone and aripiprazole in terms of their efficacy and tolerability in bipolar disorder is now available. Aripiprazole, a new agent whose proposed mechanism(s) of action differs from that of other agents, has been shown in placebo-controlled comparative trials in bipolar patients to be an effective and well tolerated treatment option for ...
Schizophrenia and bipolar disorder[edit]. Substantial dysregulation of GAD mRNA expression, coupled with downregulation of ... is observed in schizophrenia and bipolar disorder.[25] The most pronounced downregulation of GAD67 was found in hippocampal ... Cerebellar disorders[edit]. Intracerebellar administration of GAD autoantibodies to animals increases the excitability of ... Other Anti-GAD-associated neurologic disorders[edit]. Antibodies directed against glutamic acid decarboxylase (GAD) are ...
Bipolar disorder[edit]. Main article: Bipolar disorder. Bipolar I disorder can lead to severe affective dysregulation, or mood ... A relationship has been claimed between the age of onset of bipolar disorder and the occurrence of GDs. According to Carlson et ... 2000). "Suicidal behavior in bipolar mood disorder: clinical characteristics of attempters and nonattempters". Journal of ... including two-thirds of patients in manic state of bipolar disorder, half of those with schizophrenia, patients with the ...
Major depressive disorder, enuresis. Trileptal (oxcarbazepine). Epilepsy, bipolar disorder. 690 (US only). 2007[91]. Teva ... Acute pain, inflammatory disorders (such as rheumatoid arthritis). 759 (excl. OTC). 2012[83]. −4%. ... Lucentis has been approved worldwide as a treatment for wet macular degeneration and other retinal disorders; Avastin is used ... a drug to treat a growth hormone disorder; and Zelnorm, a drug for irritable bowel syndrome.[117] In September, 2010, Novartis ...
Bipolar disorder[edit]. Lamotrigine is approved in the US for maintenance treatment of bipolar I disorder and bipolar II ... schizoaffective disorder,[33] borderline personality disorder,[34] and post-traumatic stress disorder.[35][needs update] ... In bipolar disorder, it is used to treat acute episodes of depression, rapid cycling in bipolar type II, and prevent recurrence ... "Practice Guideline for the Treatment of Patients With Bipolar Disorder Second Edition. American Psychiatric Association. ...
躁鬱症分成第一型躁鬱症(英语:bipolar I disorder)與第二型躁鬱症(英语:bipolar II disorder)。它們的差別在於第一型是只要一次狂躁期發作,不論是否有鬱期出現,而第二型則是至少一次的重鬱期且伴隨至少一次的輕躁期發作所組成 ... International Society for Bipolar Disorders Task Force report on current knowledge in pediatric bipolar disorder
In one study the risk of bipolar disorder, particularly for early-onset disease, is J-shaped, with the lowest risk for children ... Single-gene disorders[edit]. Advanced paternal age may be associated with a higher risk for certain single-gene disorders ... "Advancing Paternal Age and Bipolar Disorder". Arch Gen Psychiatry. 65 (9): 1034-1040. doi:10.1001/archpsyc.65.9.1034. PMID ... Amaral, David; Dawson, Geraldine; Geschwind, Daniel (2011-06-17). Autism Spectrum Disorders. Oxford University Press, USA. ISBN ...
Bipolar affective disorder *(F31.0) Bipolar affective disorder, current episode hypomanic. *(F31.1) Bipolar affective disorder ... F31.2) Bipolar affective disorder, current episode manic with psychotic symptoms. *(F31.3) Bipolar affective disorder, current ... Bipolar affective disorder, current episode severe depression without psychotic symptoms. *(F31.5) Bipolar affective disorder, ... F25) Schizoaffective disorders *(F25.0) Schizoaffective disorder, manic type. *(F25.1) Schizoaffective disorder, depressive ...
Sarampote CS, Efron LA, Robb AS, Pearl PL, Stein MA (2002). "Can stimulant rebound mimic pediatric bipolar disorder?". J Child ... Substance abuse / Substance use disorder / Substance-related disorders. *Physical dependence / Psychological dependence / ... However, unlike similar disorders, in AWP, substituted amphetamines reduce rather than increase symptoms, and the psychosis or ... Chen CK, Lin SK, Pak CS, Ball D, Loh EW, Murray RM (2005). "Morbid risk for psychiatric disorder among the relatives of ...
Montgomery P, Richardson AJ (April 2008). "Omega-3 fatty acids for bipolar disorder". The Cochrane Database of Systematic ... including that they may tentatively be useful as an add-on for the treatment of depression associated with bipolar disorder.[52 ... Perica MM, Delas I (August 2011). "Essential fatty acids and psychiatric disorders". Nutrition in Clinical Practice. 26 (4): ... Levy SE, Hyman SL (2005). "Novel treatments for autistic spectrum disorders". Mental Retardation and Developmental Disabilities ...
"Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder". Archives of ... Journal of Affective Disorders. 94 (1-3): 121-126. PMID 16701903. doi:10.1016/j.jad.2006.03.010. Retrieved 2014-01-29.. ... Some studies shows correlation of reduced hippocampus volume and posttraumatic stress disorder (PTSD).[121][122][123] A study ... It has further been proposed that many of the changes seen are present at the start of the disorder which gives weight to the ...
Schizophrenia or bipolar disorder may be described as a phenotype but how many individual traits or "phenes" contribute to ... 4 March 2008). "Whole-genome association study of bipolar disorder". Molecular Psychiatry (online ed.). 13 (6): 558-569. doi: ... are used to distinguish groups with genetic disorders. "Phene" is used as to refer to relevant phenotypic traits in the OMIA ( ...
Berns, GS; Martin, M; Proper, S. "Limbic hyperreactivity in bipolar II disorder". Am. J. Psychiatry. 159 (304-306): 2002.. ... Anxiety Disorders Association of America: Senior Travel Award, 1999. *American Psychiatric Association: APA/SmithKline Beecham ...
Cognitions in bipolar disorder versus unipolar depression: Imagining suicide. Bipolar Disorders, Vol. 13, Nos. 7-8, pp651-661. ... Cognitions in bipolar disorder versus unipolar depression: Imagining suicide. Bipolar Disorders, Vol. 13, Nos. 7-8, 2011, pp651 ... Cognitions in bipolar disorder versus unipolar depression: Imagining suicide. Bipolar Disorders, Vol. 13, Nos. 7-8, 2011, pp651 ... Posttraumatic stress disorder Social anxiety Depression Bipolar disorder Posttraumatic stress disorder often proceeds from ...
... most often bipolar disorder. A diagnosis of type I bipolar disorder (bipolar I disorder) can be made based on a single manic ... However, most of the time, mania happens in people with bipolar disorder. Bipolar disorder causes periods of mania that switch ... "Disney' Star Demi Lovato: I'm Bipolar". Fox News. 20 April 2011.. *↑ "Bipolar Demi Lovato Talks Cutting, Eating Disorders". ... Ytham, Lakshmi N.; Kusumakar, Vivek; Kutchar, Stanley P. (2002). Bipolar Disorder: A Clinician's Guide to Biological Treatments ...
... bipolar disorder; schizoaffective disorder; psychosis; drug and alcohol dependency; port-partum psychosis; post-traumatic ... The Trust also provided a substance misuse service called Essex STaRS, as well as an eating disorders service. As a result of a ... stress disorder. The Trust had a dedicated Mother and Baby Unit, specialist dementia wards, specialist acute inpatient wards ...
Bipolar Disorders, and the Journal of Affective Disorders. He was nominated as the official advisor on mood disorders research ... Guidelines for the Biological Treatment of Bipolar Disorders: Update 2012 on the long-term treatment of bipolar disorder" (PDF ... where he heads the Bipolar Disorders Program, a worldwide leader in the clinical care, research and teaching of bipolar ... "Bipolar Disorder". www. cibersam.es. Archived from the original on June 1, 2015. Retrieved June 4, 2015. "Eduard Vieta" (PDF). ...
Bipolar Disorder. 2007 Jun;9(4):318-23. doi:10.1111/j.1399-5618.2007.00449.x PMID 17547578 Impact of publicity concerning ... He is the author of Neurobiology of Mental Illness, The Physician's Guide to Depression and Bipolar Disorders and Molecular ... doi:10.1016/j.biopsych.2006.09.033 PMID 17178112 Diagnosing bipolar disorder in trauma exposed primary care patients. Graves RE ... comparison with bipolar disorder. Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC. ...
2009). "Understanding medication non-adherence in bipolar disorders using a Necessity-Concerns Framework". J Affect Disord. 116 ... bipolar disorder; rheumatoid arthritis; inflammatory bowel disease and also for newly prescribed medications in primary care. ...
Bipolar disorder. webmd.com Tanaka, Yuki (2002) Japan's Comfort Women: Sexual slavery and prostitution during World War II and ... Like lithium carbonate and lithium chloride it was used as treatment for bipolar disorder. It has been said that during World ...
Bipolar disorder? Never have so many Emmy-deserving performances been trapped in such a muddled mess of a more than ...
... was studied for bipolar disorder throughout the 1970s.[34] Environmental impact[edit]. Main article: ... It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine ... It is used off-label as a second-line treatment for bipolar disorder and in combination with an antipsychotic in some cases of ... "Comparison of carbamazepine and lithium in treatment of bipolar disorder: a systematic review of randomized controlled trials ...
These drugs have been known to trigger bipolar disorder. In prescribing these drugs it might be well to inquire as to any ... family history of bipolar disorder. Corticosteroids should not be confused with anabolic steroids, the controversial ...
... depressive and bipolar II disorders: Evidence that they lie on a dimensional spectrum». Journal of Affective Disorders. 92 (1 ... In: Maj M, Akiskal HS, López-Ibor JJ, Sartorius N (eds.), Bipolar disorders. Chichester: Wiley & Sons, LTD; 2002. pp. 53-55. ... Mood (affective) disorders». ICD-10, Chapter V, Mental and behavioural disorders. World Health Organization (WHO). 2004. Besøkt ... Age of onset and temporal sequencing of lifetime DSM-IV alcohol use disorders relative to comorbid mood and anxiety disorders» ...
New specifier "with mixed features" can be applied to bipolar I disorder, bipolar II disorder, bipolar disorder NED (not ... Sleep-wake disordersEdit. *"Sleep disorders related to another mental disorder, and sleep disorders related to a general ... added to bipolar disorder and to depressive disorders (but are not part of the bipolar diagnostic criteria).[4] ... Neurocognitive disordersEdit. *Dementia and amnestic disorder became major or mild neurocognitive disorder (major NCD, or mild ...
"The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders". The ... Bipolar disorder. Venlafaxine is neither recommended nor approved for the treatment of major depressive episodes in bipolar ... It is used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and social phobia.[4] ... Venlafaxine is used primarily for the treatment of depression, general anxiety disorder, social phobia, panic disorder, and ...
... disorders of impulse control, and some psychiatric disorders in children.[2] In mood disorders, of which bipolar disorder is ... people with bipolar disorder had increased G-protein coupling compared to people without bipolar disorder.[72] Lithium ... "Bipolar disorder and comorbid alcoholism: Prevalence rate and treatment considerations". Bipolar Disorders. 8 (6): 677-685. doi ... It is primarily used to treat bipolar disorder and treat major depressive disorder that does not improve following the use of ...
She is introduced as being "unstable" due to bipolar disorder. Nix explains that there is "some awareness" that Polaris is the ... She is introduced as being "unstable" due to bipolar disorder. Nix explained that, within the series, there is "some awareness ...
... bipolar affective disorder; and other congenital disorders . In particular, the short stature and small brain size ... This gene is implicated in many diseases and disorders, including congenital disorders such as microcephalic osteodysplastic ... which is essential for bipolar spindle formation and chromosome assembly in early mitosis. This ensures normal function and ...
Bipolar disorder Source: Clinical Knowledge Summaries - CKS weakness and rhabdomyolysis have been included as possible adverse ...
... is a compound often used in psychiatric medicine for the treatment of bipolar disorder,Bipolar Personality Disorder (aka manic ... Molecular biology of lithium treatment for bipolar affective disorder. Bipolar is often treated with lithium.... If the bipolar ... ask any person with bipolar disorder (like me) and theyll tell you what it has done for them or a bipolar theyve known. Newer ... bipolar disorder. How vampires feel. Risperdal. If youre going to complain about store policy, dont do it to the employees!. ...
... by increase in awareness about diagnosis and treatment of bipolar disorder and unmet needs in the treatment of the disorder. ... Based on types of bipolar disorder, the market is classified into bipolar I disorder, which is mania or mixed episode; bipolar ... The global bipolar disorder market is segmented based on types of bipolar disorder, drug class, mechanism of action, and ... Increase in awareness about diagnosis and treatment of bipolar disorder and unmet needs in the treatment of the disorder are ...
Have you or someone you know been diagnosed with bipolar disorder? You may know it as manic depression. Learn about symptoms, ... Bipolar Disorder (National Institute of Mental Health) Also in Spanish * Types of Bipolar Disorder (National Institute of ... Bipolar Disorder (For Teens) (Nemours Foundation) Also in Spanish * Bipolar Disorder in Children and Teens (National Institute ... Bipolar Disorder and Black Americans (Mental Health America) * Major Ups and Downs: Bipolar Disorder Brings Extreme Mood Swings ...
Bipolar spectrum disorders includes: bipolar I disorder, bipolar II disorder, cyclothymic disorder and cases where subthreshold ... Bipolar disorder. Synonyms. Bipolar affective disorder, bipolar illness, manic depression, manic depressive disorder, manic- ... List of people with bipolar disorder, Category:Books about bipolar disorder, and Category:Films about bipolar disorder ... "Pediatric Bipolar Affective Disorder". 28 March 2018. Retrieved 28 June 2018.. *^ a b c d e f g h i j k l m n Leibenluft E, ...
Bipolar disorders are one of several medical conditions called depressive disorders that affect the way a persons brain ... Bipolar Disorder. Resources. Please Note: By clicking a link to any resource listed on this page, you will be leaving this site ... Depression and Bipolar Support Alliance. http://www.dbsalliance.org The mission of this group is to educate patients, families ... Child & Adolescent Bipolar Foundation. http://www.bpkids.org This organization offers information, resources, and a community ...
Bipolar disorders are one of several medical conditions called depressive disorders that affect the way a persons brain ... Trastorno bipolar. What Is Bipolar Disorder?. Bipolar disorders are one of several medical conditions called depressive ... manic-depressive disorder, manic-depressive illness, bipolar mood disorder, and bipolar affective disorder are medical terms ... What Causes Bipolar Disorder?. Doctors and scientists dont know the exact cause of bipolar disorder, but they think that ...
Bipolar disorder, previously known as manic depression, is a condition that affects your moods, which can swing from one ... Read more about bipolar disorder in pregnancy.. What causes bipolar disorder?. The exact cause of bipolar disorder is unknown, ... Find out more about living with bipolar disorder.. Bipolar disorder and pregnancy. Bipolar disorder, like all other mental ... Bipolar disorder and driving. If you have bipolar disorder, the condition may impair your driving. You must inform the Driver ...
Bipolar disorder in children, or pediatric bipolar disorder (PBD), is a mental disorder in children and adolescents that, like ... International Society for Bipolar Disorders Task Force report on current knowledge in pediatric bipolar disorder and future ... National Collaborating Centre for Mental Health (2006). Bipolar Disorder: The Management of Bipolar Disorder in Adults, ... guidelines on bipolar disorder in 2006 described the broadened criteria used in the US to diagnose bipolar disorder in children ...
Some people with these symptoms have bipolar disorde… ... Some people with these symptoms have bipolar disorder this ... Some people with these symptoms have bipolar disorder this video will give you some of the information youll need to know ...
Bipolar disorder is a mental illness that causes extreme mood swings between mania and depression. Learn about symptoms and ... Bipolar disorder may be caused by a chemical imbalance in the brain. Genetics may be a factor. You have a greater chance of ... People who have bipolar disorder seek care when they are depressed more often than when theyre manic. This can make it hard to ... Bipolar disorder is treated with medicines to stop the mood swings. Mood stabilizers can even out the highs and lows in your ...
... bipolar disorder causes swings in mood, energy, and the ability to function throughout the day. its known for alternating ... What is bipolar disorder?. ANSWER Also known as manic depression, bipolar disorder causes swings in mood, energy, and the ... Are borderline personality and bipolar disorder the same thing?. NEXT QUESTION: What are the symptoms of bipoloar disorder ...
... is a mental health disorder that was previously called manic depressive psychosis or manic depression. The ... Bipolar disorder is a mental health disorder that was previously called manic depressive psychosis or manic depression. The ... Symptoms of bipolar disorder. * The depressive phase. It is often the depressive phase that helps identify a person with ... However, in the case of bipolar disorder, moods may last for weeks or months at a time with a normal mood being the exception. ...
It is also called bipolar disease or manic depression. ... Bipolar disorder is a mental illness marked by extreme shifts ... Rapid-cycling bipolar disorder. Rapid-cycling bipolar disorder causes faster changes in mood than other types of bipolar ... Anxiety disorders are a commonly associated with bipolar disorder. A large number of people with bipolar disorder... READ MORE ... Bipolar and Borderline Personality Disorder Many of the symptoms of bipolar disorder and borderline personality disorder ...
Re: Bipolar disorder. Anderson and colleagues [1] state "Bipolar 1 disorder has a heritability of 0.75 explained largely by ... 1. Anderson IA, Haddad PM, Scott J. Bipolar disorder. BMJ 2013;346: 27 - 32.. 2. Ferreira MAR, Meng YA, Jones IR et al. ... The genetic basis of both bipolar disorder and schizophrenia is likely to be explained by the synergistic interaction of a ... The largest genome wide association study (GWAS) of bipolar disorder[2] with 4387 cases and 6209 controls revealed an odds ...
Bipolar disorder is a mental condition in which a person has wide or extreme swings in their mood. Periods of feeling sad and ... People with bipolar disorder are at high risk for suicide. They may use alcohol or other substances. This can make the bipolar ... Bipolar and related disorders. In: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ... Bipolar disorder is a mental condition in which a person has wide or extreme swings in their mood. Periods of feeling sad and ...
Igor Galynker, director of the Family Center for Bipolar ... that actress Catherine Zeta-Jones has sought help for Bipolar ... II Disorder, many are eager to know more about the condition. Dr. ... Shedding Light on Bipolar Disorder. Amid news that actress Catherine Zeta-Jones has sought help for Bipolar II Disorder, many ... director of the Family Center for Bipolar Disorder at Beth Israel Medical Center in New York City, sheds light on the disorder ...
Bipolar Disorder: UXL Encyclopedia of Diseases and Disorders dictionary. ... Mania: The high-energy phase of bipolar disorder.. Mixed state: A condition in which a person with bipolar disorder has the ... The causes of bipolar disorder are not completely understood, although the disorder is known to run in families. The disorder ... There are three major subtypes of bipolar disorder:. *Bipolar disorder I (BPI): The person has had at least one manic episode, ...
"bipolar disorder"[MeSH Terms] OR ("bipolar"[All Fields] AND "disorder"[All Fields]) OR "bipolar disorder"[All Fields]) AND (" ... Exacerbations of bipolar disorder triggered by chloroquine in systemic lupus erythematosus--a case report. Bogaczewicz J et al ... Malignant catatonia secondary to viral meningoencephalitis in a young man with bipolar disorder. Saini SM et al. Asia Pac ... Exacerbations of bipolar disorder triggered by chloroquine in systemic lupus erythematosus--a case report. ...
Re: Bipolar disorder. The six-page review of the management of bipolar disorder (1) gives a comprehensive appraisal of the ... 1 Anderson I, Haddad P, Scott J. Bipolar disorder BMJ 2012;345:e508 doi:10.1136/bmj.e8508 (5 January.) ... Bipolar disorder. BMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e8508 (Published 27 December 2012) Cite this as: BMJ 2012;345: ... Bipolar UK) it stated that the organisation "provides a range of self help groups and self management courses". Having attended ...
Treatments and Tools for Bipolar Disorder. Find Bipolar Disorder information, treatments for Bipolar Disorder and Bipolar ... MedHelps Bipolar Disorder Center for Information, Symptoms, Resources, ... I strongly believe my mother has Borderline Personality Disorder or Bipolar Disorder/Depres... ... I have never been on medication for Bipolar Disorder. I am wondering about what the pros an... ...
We are currently looking for an Official SelfGrowth.com Guide to "Bipolar Disorder". If you have expertise in Bipolar Disorder ... The manic phase of Bipolar I Disorder is often misdiagnosed as Narcissistic Personality Disorder (NPD). Bipolar patients in the ... Bipolar disorder, previously known as "manic depressive disorder", affects approximately one out of every hundred people, ... Bipolar is a chronic disorder that causes extreme shifts in the mood of a person. It also effects the ability to think clearly ...
We are currently looking for an Official SelfGrowth.com Guide to "Bipolar Disorder". If you have expertise in Bipolar Disorder ... The manic phase of Bipolar I Disorder is often misdiagnosed as Narcissistic Personality Disorder (NPD). Bipolar patients in the ... Bipolar disorder, previously known as "manic depressive disorder", affects approximately one out of every hundred people, ... Psychosis and Bipolar Disorder 2 I just rose out of a crying moment where I was hearing, seeing and feeling that I will never ...
The treatment of bipolar disorder is focused on reducing the severity of manic and depressive episodes and helping sufferers ... The treatment of bipolar disorder is focused on reducing the severity of manic and depressive episodes and helping sufferers ... Long-term U-M study yields framework that could be useful for studying bipolar disorder ... People diagnosed with schizophrenia or bipolar disorder may actually have treatable condition ...
Bipolar disorder is a mental health condition that causes mood shifts and extreme alterations in energy and activity levels, ... What is bipolar disorder?. Bipolar disorder involves many mixed emotions.. The main symptoms of bipolar disorder are ... www.psychiatry.org/patients-families/bipolar-disorders/what-are-bipolar-disorders Recognizing the signs of bipolar disorder. (n ... Fast facts on bipolar disorder Here are some key points about bipolar disorder. More detail is in the main article. ...
  • Heritability of bipolar spectrum disorders. (medscape.com)
  • Cade's Disease" and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder. (springer.com)
  • Bipolar disorder represents not a single disease, but a spectrum of disorders. (qualityhealth.com)
  • A new study supports earlier estimates of the prevalence of bipolar disorder in the U.S. population, and suggests the illness may be more accurately characterized as a spectrum disorder. (nih.gov)
  • The findings support international studies suggesting that, given its multi-dimensional nature, bipolar disorder may be better characterized as a spectrum disorder. (nih.gov)
  • Because bipolar spectrum disorder commonly coexists with other illnesses, it is likely underrecognized, and therefore, undertreated. (nih.gov)
  • We need better screening tools and procedures for identifying bipolar spectrum disorder, and work with clinicians to help them better spot these bipolar symptoms," concluded Dr. Merikangas. (nih.gov)
  • Patterns of brain activation during reward anticipation may help identify people most at risk for developing bipolar spectrum disorders (BPSD), according to a study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging , published by Elsevier. (elsevier.com)
  • Adapted from the Goldberg Bipolar Spectrum Screening questionnaire (c. 1993) designed to screen for the possibility of bipolar spectrum disorders in individuals 18 or older who have already experienced at least one episode of depression. (additudemag.com)
  • These three conditions together affect approximately three to four percent of the population, although recent research and clinical observations seem to indicate that bipolar spectrum disorders may impact a larger percentage of the population to a lesser degree. (psycom.net)
  • Continued efforts are being made to properly subtype the bipolar spectrum, but those patients who have sub-threshold bipolar disorder are currently diagnosed with bipolar disorder NOS, or not otherwise specified. (psycom.net)
  • Today, the leader in the realm of bipolar disorder and subtyping is undoubtedly Hagop Akiskal , a clinical researcher with great respect for Kraepelin and his classification of the bipolar spectrum. (psycom.net)
  • Until proper sub-typing of bipolar spectrum disorders is accepted and used across the board, psychiatrists who are aware of this none-too-rare subgroup are required to go outside of the DSM to diagnose these individuals. (psycom.net)
  • It has been suggested that Bipolar spectrum be merged into this article or section. (bionity.com)
  • pronounced "type one bipolar disorder") is a bipolar spectrum disorder characterized by the occurrence of at least one manic or mixed episode. (wikipedia.org)
  • Diagnosed with bipolar disorder, she is careful to take her medications and to keep her depressive moods under control. (encyclopedia.com)
  • Treatment of bipolar disorder with medications tends to relieve already existing symptoms of mania or depression and prevent symptoms from returning. (medicinenet.com)
  • When treating bipolar disorder sufferers who are pregnant or nursing , health care professionals take great care to balance the need to maintain the person's stable mood and behavior while minimizing the risks that medications used to treat this disorder may present. (medicinenet.com)
  • Bipolar medications aren't considered as risky during pregnancy as they once were, but they aren't exactly harmless either. (cnn.com)
  • Early recognition of bipolar warning signs and seeing your doctor regularly can allow you to monitor your mood and medications and keep illness from escalating. (webmd.com)
  • Bipolar disorder is treated with medications to stabilize mood. (webmd.com)
  • And just to be clear, its not one med, BiPolar patients take a Cocktail of Medications. (dailystrength.org)
  • Bipolar disorder is treated successfully with medications such as mood stabilizers, antipsychotics and antidepressants, according to the National Institute of Mental Health. (reference.com)
  • Are there any major differences between Tegretol and other medications used to treat bipolar disorder? (psycom.net)
  • Medications for depression, bipolar disorder, schizophrenia, and other mental health disorders can be lifesaving for people who need them. (qualityhealth.com)
  • But a new understanding of the disorder, a new treatment philosophy and a second-generation of medications that are safer and more effective have paved the way for bipolar sufferers to finally seek the help they need. (foxnews.com)
  • I would say the two main things that have change from the standpoint of psychological treatment are the dramatic change to psycho-social treatment that is family-based and the second-generation of antipsychotic medications that are now being used as maintenance drugs," said Dr. Igor Galynker, director of the Bipolar Family Treatment Center at Beth Israel Medical Center in New York City. (foxnews.com)
  • that airs on Oct. 30, Rene Russo reveals something about her that none of us knew: She has bipolar disorder and is treating it regularly with medications. (glamour.com)
  • In this case, however, it is difficult to say that these medications cause bipolar disorder, since several risk factors related to underlying bipolar disorder were not assessed in this study, said Baxi, who was not involved with the study. (newsmax.com)
  • For patients who are concerned about this risk of conversion to bipolar disorder, the results of this study should encourage a discussion with your doctor regarding the benefits of the antidepressant and your risk factors for developing bipolar disorder before making any changes in medications,' she said. (newsmax.com)
  • In addition, certain medications used to treat bipolar disorder may disrupt the sleep-wake cycle. (athealth.com)
  • This remains one of the few first-generation (aka typical) antipsychotic medications still used today for the treatment of bipolar (mania) . (healthyplace.com)
  • Medications are commonly used to treat pregnant patients, including those with bipolar major depression [ 1 ]. (uptodate.com)
  • Bipolar disorder is usually treated with medications and/or therapy or counseling. (bionity.com)
  • BMD has several subtypes, the most common of which are Bipolar I and Bipolar II, which is often misdiagnosed as depression. (additudemag.com)
  • Previous studies of families have already shown that there are multiple genetic subtypes of the disorder, but progress in identifying the exact genes responsible has been slow because groups of families inherit different susceptibility genes. (innovations-report.com)
  • There are several proposed revisions to occur in the diagnostic criteria of Bipolar I Disorder and its subtypes. (wikipedia.org)
  • It is likely that you will always have some degree or form of bipolar disorder. (familydoctor.org)
  • A mild form of bipolar disorder that may be somewhat disruptive in a person's life. (newsmax.com)
  • Symptoms of this severe form of bipolar disorder generally have a disruptive effect on a person's life, making it difficult to work and maintain relationships. (newsmax.com)
  • The causes of bipolar disorder aren't always clear. (medlineplus.gov)
  • The causes of bipolar disorder are not completely understood, although the disorder is known to run in families. (encyclopedia.com)
  • There are no single definitive causes of Bipolar Disorder, but research has shown that a complex. (mental-health-matters.com)
  • During a manic phase of bipolar disorder, you may feel very happy and have lots of energy, ambitious plans and ideas. (www.nhs.uk)
  • Recognize the symptoms of the manic phase of bipolar disorder. (wikihow.com)
  • Dr. Keith Ablow, a psychiatrist and FOX News contributor, said the drugs, which were developed to treat schizophrenia and other psychotic illnesses, block what is believed to be an excessive amount of dopamine produced during the manic phase of bipolar disorder. (foxnews.com)
  • The report includes a detailed analysis of the pipeline molecules under investigation within the defined data collection period to treat bipolar disorder. (businesswire.com)
  • The implication of this research is that emerging therapies for the underlying mitochondrial dysfunction could one day treat bipolar disorder more successfully than today's variable serotonin-targeting drugs. (scienceblog.com)
  • However, in the case of bipolar disorder, moods may last for weeks or months at a time with a normal mood being the exception. (news-medical.net)
  • Bipolar disorder ("manic depression ") is a mental disorder that is characterized by constantly changing moods between depression and mania . (psychcentral.com)
  • The session may include help accepting the diagnosis, education about bipolar moods, ways to identify warning signs, and intervention strategies to manage stress . (webmd.com)
  • How long these moods last and how strong they are will depend on how strong your bipolar disorder is. (wikihow.com)
  • However, moods and behaviors that change without connection to outside events and last for long periods of time can be indicative of bipolar disorder. (wikihow.com)
  • However, research has shown that the first episode of bipolar disorder is occurring earlier: It often shows up in adolescence, and even children can have the disorder. (kidshealth.org)
  • Usually, the first recognized episode of bipolar disorder is a manic episode. (psychcentral.com)
  • While bipolar disorder cannot be prevented, it's important to be aware of early warning signs of an impending episode of bipolar depression or bipolar mania. (webmd.com)
  • There are a number of factors that are believed to play a role in developing bipolar disorder Including genetics, brain chemicals, environmental factors and sometimes medical illnesses. (bartleby.com)
  • There are several available treatments that can help you manage your bipolar disorder. (healthline.com)
  • The purpose of this study is to measure the efficacy of fixed dose treatments of cariprazine for the treatment of bipolar depression. (centerwatch.com)
  • Learning the symptoms of this disorder can help you work with your trusted health care provider and get the best care and treatments you might need. (wikihow.com)
  • Insights gleaned from the study could help drive the development of treatments for a number of psychiatric disorders, according to Arking. (click2houston.com)
  • Research into new treatments for bipolar disorder include magnetic therapy, rTMS, and the Step-BD program to determine the best treatment practices for bipolar disorder. (healthyplace.com)
  • We hope our discovery will eventually lead to new treatments for depression and bipolar disorder, including possible preventive strategies, for example with drugs or even through nutritional intervention. (innovations-report.com)
  • At one time, it was believed that antidepressants could be used for treating bipolar disorder, but over time their use proved ineffective and potentially dangerous, said Galynker. (foxnews.com)
  • The fact that antidepressants for bipolar depression were not working or harmful was devastating," he said. (foxnews.com)
  • But not only do antidepressants not improve bipolar symptoms, they may increase the incidence of mania or cause mixed mania in bipolar individuals. (foxnews.com)
  • We found that antidepressants were widely prescribed and associated with a small increased risk in developing mania and bipolar disorder,' said Patel. (newsmax.com)
  • However, antidepressants may not be the best option for bipolar disorder. (cmha.ca)
  • Increase in awareness about diagnosis and treatment of bipolar disorder and unmet needs in the treatment of the disorder are the major drivers for the growth of the market. (transparencymarketresearch.com)
  • North America dominates the global bipolar disorder market due to increased awareness and larger availability of treatment options. (transparencymarketresearch.com)
  • Bipolar Treatment: Are Bipolar I and Bipolar II Treated Differently? (medlineplus.gov)
  • It's thought using a combination of different treatment methods is the best way to control bipolar disorder. (www.nhs.uk)
  • With proper treatment, individuals with bipolar can lead fulfilling, productive lives. (psychcentral.com)
  • Learn what factors prompt doctors to advise treatment for bipolar disorder. (beliefnet.com)
  • Identifying the first episode of mania or depression and receiving early treatment is essential to managing bipolar disorder. (psychcentral.com)
  • The following chapter outlines an overview of the various bipolar disorders including the diagnosis, assessment, and evidence-based treatment of the bipolar disorders. (springer.com)
  • [ 3 ] Randomized controlled trials of combination mood stabilizer treatment (more than one mood stabilizer such as atypicals + lithium + valproate) suggest this may improve outcome by increasing the time to relapse for any mood episode compared with monotherapy as maintenance therapy for Bipolar I. (medscape.com)
  • The Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) is a large, national research program to determine the best treatment practices for bipolar disorder. (healthyplace.com)
  • What are Some of the Bipolar Disorder Treatment Challenges? (healthyplace.com)
  • Take our 2-minute Bipolar quiz to see if you or a loved one may benefit from further diagnosis and treatment. (psycom.net)
  • Bipolar disorder is a lifelong condition that can be managed if you get professional treatment and support. (wikihow.com)
  • An early diagnosis and treatment plan can also greatly improve your day to day life with this disorder. (wikihow.com)
  • However, if you feel that your mood easily fluctuates day to day or week to week, speak to your doctor about whether or not you have bipolar disorder and learn what your treatment options are. (wikihow.com)
  • For example, you may say to those close to you, "I acknowledge that I have bipolar disorder and that I need help" or "I realize that I have manic depression and want to seek treatment. (wikihow.com)
  • Be proactive about getting treatment for bipolar disorder. (wikihow.com)
  • A good treatment plan can help you live better with bipolar disorder. (wikihow.com)
  • At Beth Israel's Bipolar Family Treatment Center, Galynker and staff use a family-based approach to treating bipolar disorder. (foxnews.com)
  • Bipolar disorder is a long-lasting condition that can be with regular treatment plans. (businesswire.com)
  • Most respondents with bipolar disorder reported receiving treatment. (nih.gov)
  • Nearly everyone who had bipolar I or II (89 to 95 percent) received some type of treatment, while 69 percent of those with BD-NOS were getting treatment. (nih.gov)
  • However, not everyone received treatment considered optimal for bipolar disorder. (nih.gov)
  • These include a family history of bipolar disorder, a prior depressive episode with psychotic symptoms, depression at a young age, or depression that doesn't respond to treatment, he said. (newsmax.com)
  • Take our 2-minute Bipolar quiz to see if you may benefit from further diagnosis and treatment. (psycom.net)
  • Approved for bipolar mania, mixed state and maintenance treatment. (healthyplace.com)
  • Quetiapine (Seroquel) - the only antipsychotic approved for the treatment of bipolar depression. (healthyplace.com)
  • FDA-approved for bipolar mania and mixed state treatment. (healthyplace.com)
  • One additional drug, Symbax is approved for the treatment of bipolar depression and is an olanzapine/fluoxetine (Prozac) combination. (healthyplace.com)
  • Psychoeducation - Helps the patient and their family understand bipolar disorder and seek out he best treatment and recognize warning signs. (prezi.com)
  • It's just so important to see if it's necessary to tweak or even change treatment methods when there are two disorders that coexist.Because when you're thinking you are curing one of them you could just be making the other worse! (goodtherapy.org)
  • Although a few still hold this view, the general opinion of the psychiatric community has drastically shifted over the past 30 years, a period in which diagnoses of the disorder in kids have skyrocketed. (scientificamerican.com)
  • According to the psychiatric community, I have bipolar 1 with ultra rapid cycling, but I don't take meds anymore. (selfgrowth.com)
  • the reference manual for psychiatric disorders. (nih.gov)
  • Those with bipolar I or II were more commonly treated by psychiatric specialists, while those with BD-NOS were more commonly treated by general medical professionals. (nih.gov)
  • The American Psychiatric Association's Diagnostic and Statistical Manual 4th Edition (DSM-IV) classifies Bipolar Disorder in two different categories, Bipolar Disorder I and Bipolar Disorder II. (infobarrel.com)
  • A person with this disorder will have periods of feeling joyful, energized, and excited (called mania). (hopkinsmedicine.org)
  • Zeta-Jones is said to have been diagnosed with bipolar II, which is a form of the disorder which is characterized by longer low periods. (go.com)
  • Substance abuse disorders (which have high co-morbidity with BP-II) and periods of mixed depression may also make it more difficult to accurately identify BP-II. (wikipedia.org)
  • Bipolar I is considered the classic type of bipolar disorder. (psychcentral.com)
  • Many critics have raised concerns that this manual's loosened criteria have misclassified many children as bipolar II who had features too mild to really qualify them for any type of bipolar disorder-or who suffer from entirely different ailments. (scientificamerican.com)
  • The exact cause of bipolar disorder is unknown, although it's believed a number of things can trigger an episode. (www.nhs.uk)
  • The exact cause of bipolar disorder is unknown. (medicinenet.com)
  • The cause of bipolar disorder is not known. (hopkinsmedicine.org)
  • The cause of bipolar disorder had not as of 2004 been clearly defined. (encyclopedia.com)