An insulin preparation that is designed to provide immediate and long term glycemic control in a single dosage. Biphasic insulin typically contains a mixture of REGULAR INSULIN or SHORT-ACTING INSULIN combined with a LONG-ACTING INSULIN.
Insulin that has been modified to contain an ASPARTIC ACID instead of a PROLINE at position 38 of the B-chain.
An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Substances which lower blood glucose levels.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.
Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.
Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing proteins that are involved in insulin receptor signaling.
Insulin formulations that contain substances that retard absorption thus extending the time period of action.
Antibodies specific to INSULIN.
Compounds which inhibit or antagonize the biosynthesis or action of insulin.
Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.
Fleshy and reddish outgrowth of skin tissue found on top of the head, attached to the sides of the head, and hanging from the mandible of birds such as turkeys and chickens.
Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)
The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Proteins prepared by recombinant DNA technology.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
Glucose in blood.
Self evaluation of whole blood glucose levels outside the clinical laboratory. A digital or battery-operated reflectance meter may be used. It has wide application in controlling unstable insulin-dependent diabetes.
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
Regular insulin preparations that contain the HUMAN insulin peptide sequence.
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids.
Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Multidisciplinary team most frequently consisting of INTENSIVE CARE UNIT trained personnel who are available 24 hours per day, 7 days per week for evaluation of patients who develop signs or symptoms of severe clinical deterioration.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

Impact of insulin antibodies on insulin aspart pharmacokinetics and pharmacodynamics after 12-week treatment with multiple daily injections of biphasic insulin aspart 30 in patients with type 1 diabetes. (1/17)

OBJECTIVE: This study aimed to evaluate the impact of insulin antibodies on insulin aspart pharmaco-kinetics and pharmacodynamics after 12-week multiple daily injections of biphasic insulin aspart 30 (30% fast-acting and 70% protamine-crystallised insulin aspart, BIAsp30) in patients with type 1 diabetes. METHODS: Twenty-three patients (8 women, 15 men) aged 44.8 (20.6-62.5) years (median and range) with diabetes duration of 19.5 (1.6-44.6) years and haemoglobin (Hb)A(1C) of 9.2% (8.1-12.3%) participated in the study, which consisted of 12-week treatment with multiple injections of BIAsp30. At the end of the treatment period, all patients attended two 24-h profile days 1 week apart for pharmacokinetic and pharmacodynamic assessments. HbA(1C) and insulin antibodies were also determined. RESULTS: Patients were stratified into two groups depending on whether the level of insulin binding to insulin antibodies was below or above 75% (moderate vs high (%, median and range): 62 (15-74) vs 80 (75-89)). High levels of insulin antibodies resulted in about threefold increase in AUC((0 - 24 h)) (the area under the concentration-time curve during 24 h) for total insulin aspart (analysis of variance, P < 0.05). The differences in free insulin aspart pharmacokinetics, insulin pharmacodynamics and HbA(1C) were not statistically significant between patients with different levels of insulin antibodies. Total daily insulin dosage was significantly lower in patients with high than moderate levels of insulin antibodies. CONCLUSIONS: In type 1 diabetic patients, high levels of circulating insulin antibodies result in elevated total, but not free, insulin aspart profiles. Consistent with the finding of similar insulin pharmacodynamics, the long-term glycaemic control is not significantly different between patients with different levels of insulin antibodies.  (+info)

When glycaemic targets can no longer be achieved with basal insulin in type 2 diabetes, can simple intensification with a modern premixed insulin help? Results from a subanalysis of the PRESENT study. (2/17)

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Safety and effectiveness of biphasic insulin aspart 30/70 (NovoMix 30) when switching from human premix insulin in patients with type 2 diabetes: subgroup analysis from the 6-month IMPROVE observational study. (3/17)

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Biphasic insulin aspart 30/70: pharmacokinetics and pharmacodynamics compared with once-daily biphasic human insulin and Basal-bolus therapy. (4/17)

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Intensification to biphasic insulin aspart 30/70 (BIAsp 30, NovoMix 30) can improve glycaemic control in patients treated with basal insulins: a subgroup analysis of the IMPROVE observational study. (5/17)

AIMS: The international IMPROVE observational study investigated the safety profile and effectiveness of biphasic insulin aspart 30/70 (BIAsp 30) in the routine treatment of patients with type 2 diabetes. We present analyses for the subgroup of patients who switched from basal insulin to BIAsp 30. METHODS: Patients in routine care who started insulin therapy with or switched to BIAsp 30 from existing insulin regimens were eligible for this 26-week study. This analysis includes only patients previously treated with basal insulin. Outcomes including adverse events, hypoglycaemic events and glycaemic profile were recorded from patients' notes, recall and diaries. RESULTS: Of the 748 patients included (age 59.7+/-11.8 years, diabetes duration 11.4+/-7.3 years, baseline HbA1c 9.1+/-1.6%), 497 were previously using human neutral protamine Hagedorn (NPH) insulin and 245 analogue basal insulin. Overall, major and minor hypoglycaemia rates decreased from baseline to final visit (major: 0.171 to 0.011; minor: 9.70 to 5.89 events/patient-year) and were similar between the subgroups. HbA1c and fasting blood glucose were significantly reduced from baseline (NPH prestudy: -1.6%, -2.4 mmol/l; analogue basal prestudy: -1.8%, -2.4 mmol/l), as was postprandial blood glucose, with 33.8% of patients achieving the HbA1c target < 7% without hypoglycaemia. Insulin dose increased slightly from prestudy (0.33+/-0.21 U/kg), baseline (0.40+/-0.20 U/kg) to final visit (0.52+/-0.26 U/kg); most patients (76%) followed a twice-daily regimen at final visit. Body weight did not change significantly and treatment satisfaction increased. CONCLUSIONS: Patients with type 2 diabetes inadequately controlled on basal insulins may improve their glycaemic control by intensification to BIAsp 30 therapy.  (+info)

Practical guidance on intensification of insulin therapy with BIAsp 30: a consensus statement. (6/17)

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Continuous glucose monitoring with Humalog Mix 25 versus Humalog Mix 50, twice daily: a comparative pilot study -results from the Jikei-EValuation of insulin Lispro mixture on pharmacodynamics and glycemic VariancE (J-EVOLVE) study. (7/17)

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Switching from human insulin to biphasic insulin aspart 30 treatment gets more patients with type 2 diabetes to reach target glycosylated hemoglobin < 7%: the results from the China cohort of the PRESENT study. (8/17)

BACKGROUND: The clinical importance of glycaemic control in patients with diabetes has been well established. This study aimed to explore twice-daily biphasic insulin aspart 30 (BIAsp 30) for insulin initiation in patients with type 2 diabetes mellitus (T2DM) who had poor glycaemic control with human insulins (HIs). We use data from a Chinese cohort of the PRESENT study. METHODS: In the 3-month study, Chinese subjects with T2DM started insulin therapy with BIAsp 30 in routine care. Glycaemic control was measured by glycosylated hemoglobin (HbA(1C)), fasting plasma glucose (FPG) and posting plasma glucose (PPG). The safety assessment included hypoglycaemia and other adverse events. RESULTS: A total of 1989 subjects previously treated with His were switched to BIAsp 30 for 3-month treatment. Mean HbA(1C), FPG and PPG were significantly improved after the therapy. The overall rate of hypoglycaemia decreased at the end of the trial except for the patients previously treated with long-acting insulin. Most of the events were minor and diurnal hypoglycaemia. Only one serious adverse drug reaction (SADR), a local hypersensitivity, was reported. The majority of the patients (> or = 96.7%) and physicians (> or = 84.7%) were either satisfied or very satisfied with the treatment using BIAsp 30 compared with previous HI therapy. CONCLUSION: The BIAsp 30 treatment improved both glycaemic control and patients' satisfaction without increasing hypoglycaemia in T2DM subjects inadequately controlled by His.  (+info)

This trial is conducted in the United States of America (USA). The purpose of this study is to test whether Biphasic Insulin Aspart 70/30 twice a day with Metformin improves glycemic control vs. once daily Insulin Glargine with Metformin in subjects with Type 2 Diabetes who are inadequately controlled on basal insulin plus oral anti-diabetic therapy ...
It is a proven fact that Basal Bolus insulin regimen is the near- physiological regimen & Thrice daily Biphasic Insulin Aspart is a comparable alternative for glycemic control in type 2 diabetes mellitus patients. In this study the investigators evaluated whether Biphasic Human Insulin can be used in a thrice daily regimen in place of BIAsp.. As the regimen is less expensive and one prick less than the basal-bolus regimen, it can be a good alternative for a diabetics in India.. This is a 12 week Open labelled parallel-Randomised controlled pilot study - 50 patients with type 2 Diabetes mellitus was selected after satisfying the inclusion and exclusion criterias .Metformin and pioglitazone were continued and they are randomised into 2 groups at base line and was allotted into any of the two regimens.. ...
Objective: Pharmacological profiles of biphasic insulin aspart 30/70 (BIAsp30) once-daily (OD), twice-daily (BID) and three-times-daily (TID) were compared with other insulin regimens in two crossover glucose-clamp studies in insulin-treated type 2 diabetes patients.. Methods: Study 1: BIAsp30 OD, BID and TID vs. biphasic human insulin 30/70 (BHI30) OD (n=24). Study 2: BIAsp30 TID vs. basal-bolus (insulin glargine OD plus insulin glulisine TID) (n=24). Pharmacokinetics/pharmacodynamics (PK/PD) were investigated over 24h.. Results: Study 1: PK and PD were markedly different between BIAsp30 OD and BHI30 OD: maximum insulin concentration and glucose infusion rate (GIR) were higher for BIAsp30; time to maximum metabolism was 1.7h sooner for BIAsp30. Study 2: both regimens showed three distinct prandial-related GIR peaks. GIR 24h area-under-the-curve for BIAsp TID was higher than for basal-bolus: 2585.2 vs. 2289.2 mg/kg.. Conclusions: BIAsp had pharmacological advantages over BHI. BIAsp TID had a ...
Two injections of biphasic insulin aspart (70/30, is more effective then glargine. In patients with type 2 diabetes poorly controlled on oral antidiabetic
Title: Biphasic (Premix) Insulin Analogs in Type 2 Diabetes Mellitus. VOLUME: 2 ISSUE: 2. Author(s):Abbas A. Mansour. Affiliation:Department of Medicine, Basrah College of Medicine. Hattin post office. P.O Box: 142 Basrah - 42002, Iraq.. Keywords:Type 2 diabetes mellitus, insulin analogs, glycaemic control. Abstract: One of the causes of failure to achieve target HbA1C in type 2 diabetes mellitus is delay in starting insulin .The standard insulin fails in large number because soluble insulin used for postprandial glucose control does not have a fast enough onset of action ; it needs to be given 30 and 45 minutes before meals ,and has an inappropriately prolonged duration of action, while the longer-acting zinc formulations do not have the long duration of action required of a basal insulin , even with biphasic human insulin. Biphasic insulin analogs allows delivery of both basal and prandial insulin in 1 injection that can be administered closer to mealtime, and produce greater reductions in the ...
How should I use this medication?. Your required dose of insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use the insulin. Your doctor or diabetes educator will determine the appropriate dose according to various lifestyle issues and the blood glucose values obtained while monitoring your blood glucose.. Your dose of insulin should be injected subcutaneously (under the skin) exactly as instructed by your doctor or diabetes educator. Do not inject premixed insulin into the vein and do not use premixed insulin in insulin infusion pumps. The dose of insulin is measured in international units (IU). Each mL of insulin contains 100 IU. This premixed insulin is injected about 30 minutes before certain meals. The most common schedule is to use the premixed insulin before breakfast and supper. There are many variations of insulin dosing.. Mix premixed insulin by slowly rolling the bottle or pen between your hands. Premixed insulin suspension should ...
NovoMix 30: Insulin is a naturally occurring hormone made by the pancreas that helps our body use or store the glucose (sugar) it gets from food. For people with diabetes, either the pancreas does not make enough insulin to meet the bodys requirements, or the body cannot properly use the insulin that is made. As a result, glucose cannot be used or stored properly and accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels.
Patients with Type II Diabetes who used the biphasic insulin saw their blood glucose levels drop by up to 31 per cent and episodes of major hypoglycaemia, where the glucose levels become very low, fell by an average of 94 per cent explains Professor Paul Valensi, head of the Department of Endocrinology-Diabetology-Nutrition at the Jean Verdier Hospital in France, who led the research ...
BHI has announced that more than 99% of the votes cast at the special meeting of Baker Hughes stockowners were voted to approve the combination with General Electric Companys oil and gas business.
Biphasic insulin aspart 70/30 vs. insulin glargine in insulin naive type 2 diabetes patients: modelling the long-term health economic implications in a Swedish setting
Insulin aspart protamine/insulin aspart is used for treating diabetes. This eMedTV resource discusses insulin aspart protamine/insulin aspart uses in more detail and explains how the medication works for type 1 and type 2 diabetes.
Insulin Aspart with NDC 73070-103 is a a human prescription drug product labeled by Novo Nordisk Pharma, Inc.. The generic name of Insulin Aspart is insulin aspart.
BACKGROUND: Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited. METHODS: In an open-label, controlled, multicenter trial, we randomly assigned 708 patients with a suboptimal glycated hemoglobin level (7.0 to 10.0%) who were receiving maximally tolerated doses of metformin and sulfonylurea to receive biphasic insulin aspart twice daily, prandial insulin aspart three times daily, or basal insulin detemir once daily (twice if required). Outcome measures at 1 year were the mean glycated hemoglobin level, the proportion of patients with a glycated hemoglobin level of 6.5% or less, the rate of hypoglycemia, and weight gain. RESULTS: At 1 year, mean glycated hemoglobin levels were similar in the biphasic group (7.3%) and the prandial group (7.2%) (P = 0.08) but higher in the basal group (7.6%, P | 0.001 for both comparisons). The respective proportions of patients with a glycated hemoglobin
Current International Diabetes Federation guidelines recommend a target HbA1c |7.0%, but many people with diabetes worldwide find this difficult to achieve, increasing their risk of developing complications. This publication examines the prevalence of diabetes complications and its association with baseline characteristics in people with type 2 diabetes who participated in the A1chieve study. A1chieve was a 24-week, multinational, open-label, observational study of 66,726 people with type 2 diabetes who had begun using biphasic insulin aspart 30, insulin aspart, or insulin detemir in routine clinical care. Participants were enrolled from 28 countries across four continents (Asia, Africa, Europe and South America). Baseline measurements of disease characteristics included: glycated haemoglobin (HbA1c), fasting (FPG) and post-prandial plasma glucose (PPG), high- and low-density lipoprotein cholesterol (H- or LDL-C), systolic blood pressure (SBP), and body mass index (BMI). Data on complications and use of
Buy NovoMix 30 FlexPen online by Novo Nordisk. Order safely NovoMix 30 FlexPen - 1 kit [5 x 3 ml pens (100 u/ml)]. Human peptide hormone Insulin Aspart for sale.
Risk Summary Available information from published randomized controlled trials with insulin aspart use during the second trimester of pregnancy have not reported an association with insulin aspart and major birth defects or adverse maternal or fetal outcomes [see Data]. There are risks to the mother and fetus associated with poorly controlled diabetes in pregnancy [see Clinical Considerations]. In animal reproduction studies, administration of subcutaneous insulin aspart to pregnant rats and rabbits during the period of organogenesis did not cause adverse developmental effects at exposures 8-times and equal to the human subcutaneous dose of 1 unit/kg/day, respectively.. Pre- and post-implantation losses and visceral/skeletal abnormalities were seen at higher exposures, which are considered secondary to maternal hypoglycemia. These effects were similar to those observed in rats administered regular human insulin [see Data].. The estimated background risk of major birth defects is 6-10% in women ...
Insulin Aspart - Get up-to-date information on Insulin Aspart side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Insulin Aspart
Learn about the potential side effects of insulin aspart/insulin aspart protamine. Includes common and rare side effects information for consumers and healthcare professionals.
NovoLog is the brand name for the synthetic analog called insulin aspart. It is designed to help adults and children (at least two years old) with type 1 diabetes to lower their blood sugar levels. Adults with type 2 diabetes may also take NovoLog, but it should never be taken by children with type 2 diabetes of any age. NovoLog is almost identical to regular human insulin, except for one amino acid substitution. It is produced by recombinant DNA technology using bakers yeast. There is currently no generic insulin aspart available because manufacturing generic NovoLog products in the United States is currently prohibited. In This Section1 How Does NovoLog Work2 How NovoLog Is Administered3 Side Effects of NovoLog4 Medications That May Interact with NovoLog How Does NovoLog Work NovoLog is a bolus insulin (also known as a mealtime insulin). Bolus insulin in a body without diabetes would be a burst
TY - JOUR. T1 - Efficacy of insulin analogs in achieving the hemoglobin A 1c target of AU - Giugliano, Dario. AU - Maiorino, Maria Ida. AU - Bellastella, Giuseppe. AU - Chiodini, Paolo. AU - Ceriello, Antonio. AU - Esposito, Katherine. PY - 2011/2. Y1 - 2011/2. N2 - OBJECTIVE - Insulin analogs are increasingly used in patients with type 2 diabetes. We compared the effect of basal, biphasic, prandial, and basal-bolus insulin regimens with insulin analogs to reach the hemoglobin A 1c (HbA 1c) target of 1c target of 30. RESULTS - We found 16 RCTs,with 20 comparisons and 7,759 patients. A greater proportion of patients achieved the HbA1c goal of ,7% with both biphasic (odds ratio 1.88 [95% CI 1.38-2.55]) and prandial (2.07 [1.16-3.69]) insulin compared with basal insulin; this was associated for biphasic insulin with greater hypoglycemia (event/patient/30 days, mean difference, 0.34 [range 0-0.69]) and weight gain in kg (1.0 kg [0.28-1.73]). Compared with biphasic insulin, the basal-bolus regimen ...
Before using insulin aspart, let your doctor know if you are pregnant or breastfeeding. This eMedTV page offers other precautions and warnings with insulin aspart, including information on who should not use this form of insulin.
Insulin aspart comes as a solution form that is supposed to be injected under the skin. Your health-care provider will show you the best place to inject...
Wear disease medical alert identification. • If you are 80 or older, use this medicine with caution. You could be more sensitive to low blood sugar. • Do not drive if blood sugar has been low. There is a greater risk of an accident. • If you have kidney disease, talk with healthcare provider. • Check medicines with healthcare provider. This medicine may not mix well with other medicines. • Limit alcohol intake (includes wine, beer, and liquor). • Be consistent with exercise. Increased exercise can decrease insulin needs. • Tell healthcare provider if you are pregnant or plan on getting pregnant. • Tell healthcare provider if you are breast-feeding. ...
What is this medicine? INSULIN ASPART (IN su lin AS part) is a human-made form of insulin. This drug lowers the amount of sugar in your blood.
Visit your health care professional or doctor for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your health care professional or doctor for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your health care professional or doctor for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your health care professional or doctor for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your health care professional or doctor for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your health care professional or doctor for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your health care professional or doctor for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Learn more about how the formulation of Fiasp® (insulin aspart injection) 100 U/mL, allows it to enter the bloodstream and learn how to explain the process to your adult patients. Read important safety and prescribing info on this page.
Learn more about the FullSTEP® Study, a manageable patient-titrated stepwise approach using NovoLog® (insulin aspart injection) 100 U/mL.
NovoRapid vials, prefilled pens (FlexPen and Flextouch pens) and penfill cartridges (for use with NovoPens) all contain the active ingredient insulin aspart. They are used to treat diabetes.
Insulin aspart: Search drug information, interaction, images & medical diagnosis. The most comprehensive database of medicines available in China, Hong Kon...
Here is a link to an article about this new insulin. Does anyone know when it will be available? http://www.medforum.nl/reviews/analogue_advances_in_glycaemic_control.htm ===== Marina We support the Diabetes Research Institute ~ http://www.drinet.org/ __________________________________________________ Do You Yahoo!? Get email at your own domain with Yahoo! Mail. http://personal.mail.yahoo.com/ ---------------------------------------------------------- for HELP or to subscribe/unsubscribe, contact: [email protected] send a DONATION http://www.Insulin-Pumpers.org/donate.shtml ...
Request complimentary NovoLog® and NovoLog® FlexPen® samples. Resources for licensed practitioners who can legally prescribe medication.
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We have definitely had to adjust her dosage since the change. What is so shocking is they state that a dogs reaction to the change is delayed. Disclaimer -- The content on this site is provided for informational and educational purposes only. Do not use in pregnancy. Find Us On Group 2 34A8E98BEDD6-EF4C2E. I think I kept Abby at a lower dose with Humulin, because she would experience such a wild swing of BG. The time http://www.freundeskreis-esslingen.de/spielen.html is Two available brands of NPH insulin, manufactured by Https://www.camh.ca/en/hospital/health_information/a_z_mental_health_and_addiction_information/drug-use-addiction/Pages/addiction.aspx Lilly Humulin N and Novo Nordisk Novolin N. You are deer hunter russian to visit a website outside of eMedicineHealth. Also found out the humulin has half wie macht man viel geld price as the novolin, so Ill take it! Stargame rummy number of dogs have now been reported where they were stable and doing casino 888 free games on Humulin N. Please ...
AccuPower® Plus Dualstar™ qPCR PreMix is a kit for providing accurate data from your various samples speedily. There are no additional mixing steps because it already prepared and dried for your convenient. This product makes you monitor your gene amplification of Ct in every steps of amplified florescent cycle because we add probe which include florescence oligo-nucleotide and primers. In addition, AccuPower® Plus Dualstar™ qPCR PreMix can store for two years in your -20°C freezer and you satisfy with this because we provide several different types of tube and plate depends of various qPCR machine.. ...
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Achieving tight glycaemic control early following the diagnosis of type 2 diabetes is key to optimising clinical outcomes, yet many patients and clini
PCR Yield Master Mix - High Yield PCR EcoDry Premix is a convenient, lyophilized master mix that lets you amplify DNA templates with minimal effort and maximum ease. Simply reconstitute the mix by adding PCR-grade water along with your primers and template.
For this episode of PREMIX we take a look at the 2019 Yamaha YZ250 2 stroke. Although this bike hasnt received a major update in several years we still
AccuPower®CycleScript RT PreMix (dT20 & dN12 & dN6)는 순환 온도 역전사 반응(Cyclic Temperature Reverse Transcription, CTRT, 특허등록 10-0984483)에 적합하도록 최적화된 제품입니다. 세계적으로 인정 받은 순환 온도 역전사 반응은 cDNA 합성 효율을 증가 시킬 뿐 아니라 Full-length cDNA 합성에 효과적입니다. , CycleScript reverse transcriptase, dNTPs, reaction buffer 및 primer 등 순환 온도 역전사 반응 또는 단일 온도 역전사 반응 (Fixed Temperature Reverse Transcription, FTRT) 에 필요한 구성 성분을 혼합하여 1회 분량씩 건조 시킨 제품입니다. 실험자는 Template RNA 준비만으로 cDNA 합성을 할 수 손쉽게 할 수 있도록 고안된 제품입니다. 본 제품은 기존의 역전사 반응 온도인 42℃ 뿐만 아니라 높은 온도인 55℃ 에서도 RT 반응을 할 수 있어 단일 온도의 역전사 반응과 함께 순환 온도 역전사 반응을 할 수 있도록 개발 ...
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FRIDAY, April 14, 2017 (HealthDay News) -- Fast-acting insulin aspart improves glycemic control in type 1 diabetes, according to a study published online April 11 in Diabetes Care.. David Russell-Jones, M.B.B.S., M.D., from the Royal Surrey Country Hospital in Guildford, U.K., and colleagues examined the efficacy and safety of fast-acting insulin aspart (faster aspart) versus conventional insulin aspart (IAsp) in a multicenter phase 3 trial. Adults with type 1 diabetes were randomized to either double-blind mealtime faster aspart (381 adults), IAsp (380 adults), or open-label postmeal faster aspart (382 adults).. The researchers found that in both treatment groups, hemoglobin A1c (HbA1c) was reduced, and noninferiority to IAsp was confirmed for both mealtime and postmeal faster aspart (estimated treatment difference: mealtime, −0.15 percent; postmeal, 0.04 percent). There was a statistically significant reduction in HbA1c for mealtime faster aspart versus IAsp (P = 0.0003). At one hour and two ...
Insulin Aspart: Find the most comprehensive real-world treatment information on Insulin Aspart at PatientsLikeMe. 57 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, systemic lupus erythematosus, diabetes type 2, post-traumatic stress disorder, rheumatoid arthritis, bipolar disorder, Parkinsons disease, panic disorder, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, amyotrophic lateral sclerosis, persistent depressive disorder (dysthymia), epilepsy, migraine, hypothyroidism, osteoarthritis, attention deficit/hyperactivity disorder, bipolar II disorder, traumatic brain injury, asthma, high cholesterol (hypercholesterolemia), social anxiety disorder, irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or mild depression currently take Insulin Aspart.
Purpose The efficacy and safety of insulin degludec/insulin aspart (IDegAsp) once daily (OD) weighed against insulin glargine U100 (IGlar) OD over 52 weeks in insulin-na?ve adults with type 2 diabetes mellitus (T2DM) was investigated. both in treatment groups. The pace of verified hypoglycemic shows was 86% higher (< 0.0001) whereas the pace of nocturnal hypoglycemia was 75% decrease (< 0.0001) for IDegAsp versus IGlar. Summary Nocturnal-confirmed hypoglycemia was higher with IGlar whereas general and diurnal hypoglycemia had been higher with IDegAsp dosed at breakfast time. These total outcomes focus on the significance of administration of IDegAsp with the primary food of your day, tailored to the average person patients desires. Trial Enrollment ClinicalTrials.gov: type:clinical-trial,attrs:text:NCT01045707,term_id:NCT01045707NCT01045707 [primary]) and NCT01169766 [ext] Launch Type 2 diabetes mellitus (T2DM) is seen as a increasing insulin level of resistance and an inexorable ...
Advice and warnings for the use of Insulin aspart / insulin degludec (Ryzodeg 70/30) during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out
INTRODUCTION: The treatment of patients with type 2 diabetes uncontrolled on basal insulin and oral glucose-lowering drugs was investigated previously in the LixiLan-L trial. In the LixiLan-L trial, patients experienced a 6-week run-in with insulin glargine U100 (iGlar) as part of the screening phase, followed by treatment with a fixed-ratio combination of iGlar + lixisenatide (iGlarLixi) or iGlar alone over 30 weeks. In the study reported here, we investigated the achievement of glycemic control in those who completed the 30-week LixiLan-L trial, as assessed by change in glycated hemoglobin (HbA1c) levels from screening, both for the overall category and for screening HbA1c subcategories ...
At 05:26 PM 6/27/2001 Neal & Kara wrote: ,My doc just gave me 5 vials of Novolog. He suggested I switch from pumping ,Hummalog to this stuff in my H-tron plus. H says this insulin should be a ,little more stable in my pump, but that it may have a little longer tail ,than the H Im used to. He wants me to start with the same carb:insulin ,ratios for boluses, and the same basals, but just chart really carefully for ,a while to see how it goes. , ,Has anyone out there switched who has switched from Hummalog to Novolog ,noticed any change that I should be alert to? Thanks. Last week, my doctor gave me a sample bottle of Novolog to try too. Im just starting my second reservoir today. My initial impression is that for me, it is faster than Humalog. Humalog responded very slowly for me... peaking in about 3 hours. My initial feelings are that Novolog is peaking somewhere around 2 hours. This is about a 1/3 faster speed for me, which is very good news. Ill know more as I get a bit more time to ...
CGMS is a useful tool for assessing daily glucose fluctuations (5) but has certain limitations: It measures glucose concentrations in the extracellular interstitium rather than in the intravascular space. The relationship between glucose concentrations in these two compartments is not straightforward and may alter according to physiological variation in insulin concentration and glucose uptake, utilization, and elimination (6,7). These limitations are countered by the ability to record continuous glucose data and detect unrecognized hypoglycemic episodes (8-13). Most studies to date have involved patients with type 1 diabetes, and there is relatively little information describing CGMS in type 2 diabetic patients.. In the present study, CGMS demonstrated that rates of IG ,3.5 and ,2.5 mmol/l at night were approximately double those during the day in patients with type 2 diabetes treated with premixed insulins BIAsp 30 and BHI 30. This is contrary to the general perception, based on self-reported ...
Type-2 diabetes mellitus (T2DM) is a progressive condition in which the level of glycated hemoglobin rises inexorably over time, and the function of
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A new formulation of insulin aspart injection (Fiasp, Novo Nordisk) has received FDA approval. Fiasp 100 units/mL is a fast-acting mealtime insulin indicated to improve glycemic control in adults with type-1 and type-2 diabetes. Fiasp can be dosed at the beginning of a meal or within 20 minutes after ...
A new formulation of insulin aspart injection (Fiasp, Novo Nordisk) has received FDA approval. Fiasp 100 units/mL is a fast-acting mealtime insulin indicated to improve glycemic control in adults with type-1 and type-2 diabetes. Fiasp can be dosed at the beginning of a meal or within 20 minutes after ...
This trial investigated the efficacy and tolerability of investigator-driven titration versus subject-driven titration of insulin aspart/insulin protamine
In the main beaker mix A ingredients and start to heat to 75°C. In a side beaker, premix B and add to A at 60°C. Mix until clear. In a side beaker, premix C until clear, add it to main beaker at 65°C and mix well. At 70°C, sprinkle in UltraThix and homogenize until smooth, then sprinkle in Antaron/Ganex and homogenize until smooth. At 75°C, add E to the main beaker and homogenize until the color is homogeneous. In a side beaker, heat F ingredients at 75°C. At 75°C, add F into the main beaker and homogenize well. Begin to cool down the batch. In a side beaker at RT, premix G ingredients until smooth. At 60°C, add G into the main beaker and homogenize well. In a side beaker at RT, premix H until clear and add to the main beaker. Mix well (viscosity increases). At 30°C, add I and mix well. Stop at 25° ...
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The Nuscience Group, the premix and feed specialty business of the Agrifirm group, has appointed Jan Smulders as its Chief Operating Officer from October 1st 2011.
article{833773, abstract = {Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated. Methods: TTR was measured using immunonephelometry in a group of patients (n = 77) in longstanding ({\textrangle} 1 week) retinal detachment (n = 29), fresh ({\textlangle} 1 week) retinal detachment (n = 17), macular holes (n = 20) or diabetic retinopathy (n = 11). Vitreous samples were taken at the start of every vitrectomy procedure. For reference values, cadaver specimens (n = 73) were used. Results: Reference values for vitreous TTR (median 18 mg/l; IQR 4 to 24 mg/l) comprised 2.2\% of reference values for vitreous protein levels (median 538 mg/l; IQR 269 to 987 mg/l). Vitreous TTR values of patients were comparable in all disorders. Vitreous TTR values were higher in phakic (median 22.5 mg/l; IQR 10 to 27 mg/l) ...
Klisic J, Hu MC, Nief V, Reyes L, Fuster D, Moe OW, Ambühl PM (2002). "Insulin activates Na(+)/H(+) exchanger 3: biphasic ... There is a specific protein functioning as an NHE3 regulator, Sodium-hydrogen antiporter 3 regulator 1. Tenapanor Insulin ...
See also: Human insulin. Biphasic insulin A type of pharmaceutical insulin that is a mixture of intermediate- and fast-acting ... Ultralente insulin A type of insulin that is long acting. Medical ultrasound Unit of insulin The basic measure of insulin. U- ... Lente insulin A type of insulin that is intermediate-acting, between NPH insulin and ultra-lente insulin. Limited joint ... Insulin pen An insulin injection device the size of a pen that includes a needle attached to a vial of insulin. It can be used ...
March 2015). "L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2 ... Hormones such as insulin up-regulate expression of PKM2 while hormones like tri-iodothyronine (T3) and glucagon aid in down- ... Alternatively, insulin interferes with the effect of glucagon, cyclic AMP and epinephrine, causing pyruvate kinase to function ... July 2013). "Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2 ...
This effect is biphasic. Initially fatty acids potentiate the effects of glucose. After prolonged exposure to high fatty acid ... Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus". Lancet. 1 (7285): 785-9. doi:10.1016/ ... It is theorized to play a role in explaining type 2 diabetes and insulin resistance. It was named for Philip Randle, who ... FAT/CD36 may be controlled by insulin and AMPK. Increased transport coupled to the formation of the CoA derivatives and the ...
While one separatory funnel is useful in separating certain compound mixtures with a carefully formulated biphasic solvent ... The CCD technique was employed in many notable separations such as penicillin, polycyclic aromatic hydrocarbons, insulin, bile ... Craig continued to pursue this method of separation by testing different compounds, formulating biphasic solvent systems, and ... Harfenist, Elizabeth J.; Craig, Lyman C. (1951). "Countercurrent Distribution of Insulin". Journal of the American Chemical ...
... biphasic insulin injection (INN) Biphetamine Biphetap biricodar (INN) biriperone (INN) Bisac-Evac bisacodyl (INN) bisantrene ( ...
This biphasic understanding eventually evolved to accommodate a third, even slower phase of insulin release. These discoveries ... Grodsky has researched and published extensively on a number of topics relating to insulin, factors affecting insulin release, ... and secretion of insulin by the pancreas. In 1960, to further understand the forms of insulin release, Grodsky engineered the ... since injections deliver the insulin all at once. The need was thus identified for a method of pumping insulin into the body in ...
"Insulin regular". Drug Information Portal. U.S. National Library of Medicine. "Insulin [Injection], biphasic". Drug Information ... insulin and a rapid/regular insulin to provide both a basal insulin and prandial insulin. There are several challenges involved ... Medical preparations of insulin are never just 'insulin in water'. Clinical insulins are specially prepared mixtures of insulin ... Prandial insulin, also called mealtime or bolus insulin, is designed as a bolus dose of insulin prior to a meal to regulate the ...
"Insulin". Drug Information Portal. U.S. National Library of Medicine. "Insulin [Injection], biphasic". Drug Information Portal ... Regular insulin, also known as neutral insulin and soluble insulin is a type of short-acting insulin. It is used to treat type ... Versions are also available mixed with longer-acting versions of insulin, such as NPH insulin. Regular insulin is used for the ... human insulin injection [rDNA origin]) is a mixture insulin. It is an intermediate-acting insulin combined with the onset of ...
Addition of Biphasic, Prandial, or Basal Insulin to Oral Therapy in Type 2 Diabetes; (2006) Rury R. Holman, M.B., Ch.B., F.R.C. ... Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin ... Insulin detemir is a long-acting human insulin analogue for maintaining the basal level of insulin. Novo Nordisk markets it ... Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin- ...
GLP-1 ensures the β cell insulin stores are replenished to prevent exhaustion during secretion by promoting insulin gene ... GLP-1 is released in a biphasic pattern with an early phase after 10-15 minutes followed by a longer second phase after 30-60 ... The most noteworthy effect of GLP-1 is its ability to promote insulin secretion in a glucose-dependent manner. As GLP-1 binds ... As opposed to common treatment agents such as insulin and sulphonylurea, GLP-1-based treatment has been associated with weight ...
Tetrahydrocannabinol (THC: C21H30O2) is found to lower production of NAE 20:4 (AEA) by a biphasic response after THC injection ... And this stimulation of adiponectin production and inhibition of lipolysis from THC may be in favor of improved insulin ... as well as insulin production, secretion, and resistance, where animal and human research suggest that increased activity of ... the endocannabinoid system, may lead to insulin resistance, glucose intolerance and obesity. Consistent with the associated ...
In each of these phobias, a biphasic fainting response is a common reaction to a trigger. In a majority of specific phobias, ... Avoidant behaviors can be especially detrimental to an individual's well-being if they are diabetic and require insulin ... While BII-phobics experience a similar reaction initially upon exposure, most ultimately respond to a trigger with a biphasic, ...
In 1982, a new version of the Pill was introduced, known as the "biphasic" pill. By 1985, a new triphasic pill was approved. ... Androgens, antiandrogens, estrogens, gonadotropin, corticosteroids, human growth hormone, insulin, antidiabetics (sulfonylureas ... and insulin for diabetes. Other drugs included antitoxins, a few biological vaccines, and a few synthetic drugs. In the 1930s, ... "biphasic" pill, and "triphasic" pill Stimulants: methylphenidate, amphetamine Tranquilizers: meprobamate, chlorpromazine, ...
Diabetes mellitus type 2 is a common disease that causes reduced insulin secretion and increased insulin resistance in the ... Ueno S, Weidinger G, Osugi T, Kohn AD, Golob JL, Pabon L, Reinecke H, Moon RT, Murry CE (June 2007). "Biphasic role for Wnt/ ... This ROS-induced damage is significant because it can cause acute hepatic insulin resistance, or injury-induced insulin ... Insulin is a peptide hormone involved in glucose homeostasis within certain organisms. Specifically, it leads to upregulation ...
Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes". J. Biol. Chem. 269 (39): 23865-8. PMID ... Hu LD, Zou HF, Zhan SX, Cao KM (2007). "Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative ...
Acute insulin treatment increases PtdIns(3,5)P2 levels in 3T3L1 adipocytes, both in isolated membranes and intact cells to ... Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, ... and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Mol Cell Biol ... ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes. Exp ...
While oral antidiabetic drugs are sometimes used, the recommended treatment is the use of insulin injections or an insulin pump ... Other methods such as biphasic cuirass ventilation, and associated clearance mode available in such devices, integrate a cough ... Moran A, Pyzdrowski KL, Weinreb J, Kahn BB, Smith SA, Adams KS, Seaquist ER (August 1994). "Insulin sensitivity in cystic ... The pancreas contains the islets of Langerhans, which are responsible for making insulin, a hormone that helps regulate blood ...
This process can lower blood sugar and promote insulin secretion and release. Reduction of sugar intake: G. sylvestre extracts ... A test of the biphasic model for the action of gymnemic acid". Chemical Senses. 7 (2): 143-152. doi:10.1093/chemse/7.2.143. ... Diabetes: Early research suggests when a specific gymnema extract (GS4) is taken orally along with insulin or diabetes ...
"Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene ... patients with diabetes may need increased insulin or diabetic therapies Menstrual abnormalities Lower response to hormones, ...
These mice slowly develop a hepatic and muscular steatosis accompanied with insulin resistance. However, none of the Tg mice ... and reveals a biphasic activation of genes in surviving tissue". Journal of Neurochemistry. 96 (1): 14-29. doi:10.1111/j.1471- ... "Human apolipoprotein D overexpression in transgenic mice induces insulin resistance and alters lipid metabolism". American ...
In 1982, a new version of the Pill was introduced, known as the "biphasic" pill. By 1985, a new triphasic pill was approved. ... androgens, antiandrogens, estrogens, gonadotropin, corticosteroids, human growth hormone, insulin, antidiabetics (sulfonylureas ... and insulin for diabetes. Other drugs included antitoxins, a few biological vaccines, and a few synthetic drugs. In the 1930s ... biguanides/metformin, thiazolidinediones, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin ...
Kirkman-Brown JC, Bray C, Stewart PM, Barratt CL, Publicover SJ (June 2000). "Biphasic elevation of [Ca(2+)](i) in individual ... Progesterone plays an important role in the signaling of insulin release and pancreatic function, and may affect the ...
"Calcium release channel RyR2 regulates insulin release and glucose homeostasis". The Journal of Clinical Investigation. 125 (5 ... of Ca2+ by the MAM allows for spatio-temporal patterning of Ca2+ signaling because Ca2+ alters IP3R activity in a biphasic ...
... an unexpected cause of insulin resistance and diabetes". Endocrinology and Metabolism Clinics of North America. 43 (1): 187-204 ... Evidence suggests that CPAP may improve sensitivity to insulin, blood pressure, and sleepiness.[51][52][53] Long term ... Biphasic and polyphasic sleep. *Chronotype. *Dream journal. *Excessive daytime sleepiness. *Hypnopompic state ... "Meta-analysis: continuous positive airway pressure improves insulin resistance in patients with sleep apnea without diabetes" ...
"Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity". Sleep Medicine ...
In 1982, a new version of the Pill was introduced, known as the "biphasic" pill. By 1985, a new triphasic pill was approved. ... androgens, antiandrogens, estrogens, gonadotropin, corticosteroids, human growth hormone, insulin, antidiabetics (sulfonylureas ... and insulin for diabetes. Other drugs included antitoxins, a few biological vaccines, and a few synthetic drugs. In the 1930s, ... biguanides/metformin, thiazolidinediones, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin ...
... and vials all contain human biphasic isophane insulin. They are used to treat diabetes. ... The insulin works in the same way as natural insulin, by binding to insulin receptors on cells in the body. Insulin causes ... Together, this combination of insulin is called biphasic isophane insulin. Insuman comb 15 contains 15% soluble insulin and 85 ... Insuman comb 50 contains 50% soluble and 50% isophane insulin.. Soluble insulin is known as short acting insulin. It works ...
... and Humalog Mix 25 KwikPen prefilled pens all contain biphasic insulin lispro. They are used to treat diabetes. ... The insulin works in the same way as natural insulin, by binding to insulin receptors on cells in the body. Insulin causes ... insulin lispro (25 per cent) and insulin lispro protamine (75 per cent). Together, the combination is called biphasic insulin ... Humalog Mix25 (biphasic insulin lispro). Humalog Mix 25 vials, Humalog Mix 25 cartridges (for use with Autopen Classic or ...
Biphasic insulin - A type of insulin that is a mixture of intermediate- and fast-acting insulin, is clearly explained in ... Medical Word - Biphasic insulin. Ans : A type of insulin that is a mixture of intermediate- and fast-acting insulin. ... Biphasic insulin - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review ...
Two injections of biphasic insulin aspart (70/30, is more effective then glargine. In patients with type 2 diabetes poorly ... the use of biphasic insulin aspart (70/30 BIAsp) appears to be more effective than long-acting insulin glargine in achieving ... Biphasic Insulin Analog More Effective Than Glargine in Diabetes Control. Share * Facebook ... Home / Resources / Articles / Biphasic Insulin Analog More Effective Than Glargine in Diabetes Control ...
Glucose-stimulated biphasic insulin secretion involves at least two signaling pathways, the KATP channel-dependent and KATP ... Glucose-stimulated signaling pathways in biphasic insulin secretion Diabetes Metab Res Rev. Nov-Dec 2002;18(6):451-63. doi: ... Glucose-stimulated biphasic insulin secretion involves at least two signaling pathways, the KATP channel-dependent and KATP ... Activation of voltage-dependent Ca(2+) channels increases Ca(2+) entry and [Ca(2+)]i and stimulates insulin release. The KATP ...
The aim of this clinical trial is to compare NN5401 with biphasic insulin aspart... ... Effect of Biphasic Insulin Compared to Biphasic Insulin Combined With Insulin Aspart, With or Without Metformin in Type 2 ... The objective of the study is to compare glycemic control of Biphasic insulin Aspart 30 twice daily with Biphasic insulin ... Biphasic insulin aspart-30 reduces glycemic variability to a greater degree than insulin detemir: A randomized controlled trial ...
... Rorsman, Patrik LU ; Eliasson, Lena LU ; Renström, Erik LU ; Gromada, Jesper ... Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules ... Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules ... Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type ...
A10AB01 - Insulin (Human)*A10AC01 - Insulin (Human)*A10AD01 - Insulin (Human)*A10AE01 - Insulin (Human)*A10AF01 - Insulin ( ...
The aim of this trial is to evaluate the efficacy of metformin plus biphasic insulin aspart or insulin NPH on blood glucose ... Evaluation of Efficacy and Safety of Metformin Plus Biphasic Insulin Aspart or Insulin NPH in Subjects With Type 2 Diabetes. ... Efficacy and Safety of Metformin Plus Biphasic Insulin Aspart 30 in Type 2 Diabetes. The safety and scientific validity of this ... Efficacy and Safety of Metformin Plus Biphasic Insulin Aspart 30 in Type 2 Diabetes. ...
Insulin, Globin Zinc. Insulin Aspart. Insulin, Long-Acting. Insulin degludec, insulin aspart drug combination. Biphasic ... Bioequivalence of Two Formulations of Biphasic Insulin Aspart 50 in Healthy Male Subjects. The safety and scientific validity ... Drug: biphasic insulin aspart 50 A single dose of each formulation administered subcutaneously (s.c., under the skin) on 2 ... Drug: biphasic insulin aspart 50 A single dose of each formulation administered subcutaneously (s.c., under the skin) on 2 ...
... insulin aspart protamine drug combination 30:70. Insulin. Insulin Aspart. Insulin, Long-Acting. Biphasic Insulins. Insulin, ... Insulin, Globin Zinc. Insulin degludec, insulin aspart drug combination. Insulin aspart, ... The aim of this trial is to investigate the efficacy and safety of biphasic insulin aspart 30 as start insulin in subjects with ... Efficacy and Safety of Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes. The safety and scientific validity of this ...
biphasic human insulin 30/70 (BHI30) OD (n=24). Study 2: BIAsp30 TID vs. basal-bolus (insulin glargine OD plus insulin ... Biphasic insulin aspart 30/70 (BIAsp 30): pharmacokinetics (PK) and pharmacodynamics (PD) in comparison with once-daily ... Biphasic insulin aspart 30/70 (BIAsp 30): pharmacokinetics (PK) and pharmacodynamics (PD) in comparison with once-daily ... Biphasic insulin aspart 30/70 (BIAsp 30): pharmacokinetics (PK) and pharmacodynamics (PD) in comparison with once-daily ...
Biphasic Insulin Aspart Arm Total Arm/Group Description subcutaneous injection, twice daily... subcutaneous injection, twice ... Biphasic Insulin Aspart Arm Arm/Group Description subcutaneous injection, twice daily... subcutaneous injection, twice daily ... Biphasic Insulin Aspart Arm Arm/Group Description: subcutaneous injection, twice daily... subcutaneous injection, twice daily ... Biphasic Insulin Aspart Arm Arm/Group Description: subcutaneous injection, twice daily... subcutaneous injection, twice daily ...
... using either biphasic insulin aspart 30 (BIAsp 30) or biphasic human insulin 30 (BHI 30). ... with the conventional human premix biphasic human insulin 30 (BHI 30) (30% regular insulin, 70% NPH insulin), using a ... to Measure the Frequency of Low Glucose Values When Using Biphasic Insulin Aspart 30 Compared With Biphasic Human Insulin 30. A ... to Measure the Frequency of Low Glucose Values When Using Biphasic Insulin Aspart 30 Compared With Biphasic Human Insulin 30 ...
... even with biphasic human insulin. Biphasic insulin analogs allows delivery of both basal and prandial insulin in 1 injection ... even with biphasic human insulin. Biphasic insulin analogs allows delivery of both basal and prandial insulin in 1 injection ... Biphasic (Premix) Insulin Analogs in Type 2 Diabetes Mellitus. Author(s): Abbas A. Mansour. Department of Medicine, Basrah ... Abbas A. Mansour, " Biphasic (Premix) Insulin Analogs in Type 2 Diabetes Mellitus", Recent Patents on Endocrine, Metabolic & ...
Insulin degludec/insulin aspart vs biphasic insulin aspart 30 twice daily in Japanese patients with type 2 diabetes: A ... Comparison of insulin degludec/insulin aspart and biphasic insulin aspart 30 in uncontrolled, insulin-treated type 2 diabetes: ... Insulin degludec/insulin aspart versus biphasic insulin aspart 30 twice daily in insulin-experienced Japanese subjects with ... TY - JOUR T1 - Insulin degludec/insulin aspart vs biphasic insulin aspart 30 twice daily in Japanese patients with type 2 ...
... clinicaltrials.gov The primary objective is to demonstrate the non-inferiority at six months of a basal plus one insulin ... Home » Topics » Insulin Therapy » Research » Comparison of a Basal Plus One Insulin Regimen With a Biphasic Insulin Regimen in ... Comparison of Pharmacodynamics and Pharmacokinetics of Biphasic Insulin Aspart 30 and Insulin Glargine and Insulin Glulisine ... insulin regimen (. Lantus plus one injection of Apidra) compared with a biphasic insulin regimen (NovoMix 30) at controlling ...
... on glucose-stimulated insulin secretion was studied using: (1) an in vitro isolated pancreas perfusion system, and (2) an in ... Ethanol-insulin interrelationships in the rat studied in vitro and in vivo: evidence for direct ethanol inhibition of biphasic ... The data suggest that stimulus-induced insulin secretion may be enhanced by an ETOH metabolite if the ETOH exposure is ... ETOH exposure in vitro resulted in a decrease in glucose-stimulated insulin secretion from the perfused rat pancreas. Second ...
The biphasic stimulation of insulin secretion by bombesin involves both cytosolic free calcium and protein kinase C. S L Swope ... The biphasic stimulation of insulin secretion by bombesin involves both cytosolic free calcium and protein kinase C ... The biphasic stimulation of insulin secretion by bombesin involves both cytosolic free calcium and protein kinase C ... The biphasic stimulation of insulin secretion by bombesin involves both cytosolic free calcium and protein kinase C ...
... biphasic insulin aspart 30) or Levemir® (insulin detemir) in subjects with type 1 or 2 diabetes mellitus.. Clinical Trials ... The aim of this trial is to investigate efficacy and safety of NovoMix® 30 (biphasic insulin aspart 30) or Levemir® (insulin ... Biphasic Insulin Aspart 30) or Levemir® (Insulin Detemir) for Treatment of Type 1 or Type 2 Diabetes Mellitus in Macedonia ...
Direct effect of insulin on the synthesis of specific plasma proteins: Biphasic response of hepatocytes cultured in serum- and ... Addition of insulin to the medium elicited a biphasic stimulation of plasma protein synthesis: a rapid response of the ... Addition of insulin to the medium elicited a biphasic stimulation of plasma protein synthesis: a rapid response of the ... Addition of insulin to the medium elicited a biphasic stimulation of plasma protein synthesis: a rapid response of the ...
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Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules ... Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type ... Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules ... Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type ...
... in the biphasic group. Total mean insulin dose fell from 80 units (SD 12) to 61 units (SD 11) in the biphasic group, but ... Patient mixed biphasic insulin in a diabetic clinic. The Ceylon Medical Journal. 1997 Sep; 42(3): 137-8. ... CONCLUSION: Patient mixed and administered biphasic insulin on a twice daily basis is feasible, acceptable to patients, results ... biphasic) insulin administered twice a day. PATIENTS: A cohort of 25 patients with poor glycaemic control on a single dose of ...
Similar glucose control with basal-bolus regimen of insulin detemir plus insulin aspart and thrice-daily biphasic insulin ... insulin detemir (IDet) and aspart (IAsp)] versus biphasic insulin aspart 30 (BIAsp30) in insulin-naive type 2 diabetes mellitus ... Insulin initiation and intensification using IDet+IAsp was not inferior to BIAsp1-2-3 in insulin-naive patients with T2DM not ... Similar glucose control with basal-bolus regimen of insulin detemir plus insulin aspart an ...
To assess the financial consequences of different adoption rate of Biphasic Insulin Aspart (BIAsp) 30 instead of Biphasic Human ... Biphasic insulin aspart 30 treatment for people with type 2 diabetes: a budget impact analysis based in Thailand. ... Biphasic insulin aspart 30 treatment for people with type 2 diabetes: a budget impact anal ... The NBI per insulin user per year was 33.45 THB (0.97 USD), 67.27 THB (1.96 USD), 101.49 THB (2.95 USD) from year 1 to year 3, ...
Comparison of Insulin Degludec/Insulin Aspart and Biphasic Insulin Aspart 30 in Uncontrolled, Insulin-Treated Type 2 Diabetes: ... exercise GLP1 glycaemic control gut HbA1c heart failure hyperglycemia hypoglycemia incretin insulin insulin pump Insulin ...
What is Insulin recombinant purified human? Meaning of Insulin recombinant purified human medical term. What does Insulin ... Looking for online definition of Insulin recombinant purified human in the Medical Dictionary? Insulin recombinant purified ... biphasic insulin. An insulin preparation that includes two components, typically a rapidly acting insulin, e.g., regular ... Other problems of insulin therapy include insulin allergy, insulin resistance, insulin rebound due to the somogyi effect, and ...
Insulin pork explanation free. What is Insulin pork? Meaning of Insulin pork medical term. What does Insulin pork mean? ... Looking for online definition of Insulin pork in the Medical Dictionary? ... biphasic insulin. An insulin preparation that includes two components, typically a rapidly acting insulin, e.g., regular ... Other problems of insulin therapy include insulin allergy, insulin resistance, insulin rebound due to the somogyi effect, and ...
  • In patients with type 2 diabetes poorly controlled on oral antidiabetic drugs, the use of biphasic insulin aspart (70/30 BIAsp) appears to be more effective than long-acting insulin glargine in achieving glycemic control. (diabetesincontrol.com)
  • The objective of the study is to compare glycemic control of Biphasic insulin Aspart 30 twice daily with Biphasic insulin Aspart 30 twice. (bioportfolio.com)
  • The purpose of this study is to compare the change in glycemic control, as measured by hemoglobin A1c (HbA1c) from baseline to study week 24, in subjects receiving insulin glulisine as mea. (bioportfolio.com)
  • Conclusions In this analysis, BIAsp-30 was associated with improved glycemic control (HbA1c) compared with BHI-30 in insulin-naive patients with type 1 or type 2 diabetes and insulin-experienced patients with type 2 diabetes. (cf.ac.uk)
  • Conclusions biphasic insulin 50/50 is effective for achieving glycemic control in suboptimal HbA1c levels, especially among obese patients with insulin-treated diabetes. (bmj.com)
  • The introduction of insulin therapy to achieve adequate glycemic control in patients with type 2 diabetes mellitus (T2DM) is inherent to the progressive deterioration of the pancreatic β-cell function. (bmj.com)
  • BACKGROUND: Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited. (ox.ac.uk)
  • We demonstrate the correct targeting and processing of the tagged insulin and normal glycemic control of the pig model. (pnas.org)
  • Adding insulin to oral therapy in type 2 diabetes is essential when glycemic control is suboptimal. (renalandurologynews.com)
  • The addition of insulin can result in better glycemic control, as evidenced by a decline in glycated hemoglobin levels. (renalandurologynews.com)
  • However, basal insulin therapy added to oral hypoglycemic agents results in good glycemic control in only a small proportion of patients. (renalandurologynews.com)
  • We, a Saudi task force, gathered to develop an explicit, evidence-based consensus for the use of the low-mix premixed insulin for better glycemic control. (scirp.org)
  • The use of insulin analogs in type 1 and type 2 diabetes mellitus provides a better balance between glycemic control and hypoglycemia compared with human insulins, with the resultant potential to reduce the costs of treatment of hospitalization and chronic complications. (ajmc.com)
  • Insulin analogs versus conventional human insulins improve the balance between glycemic control and hypoglycemia. (ajmc.com)
  • The second group received biphasic insulin aspart (titrated to achieve an optimal balance between glycemic control and risk of hypoglycemia as dictated by best clinical practice), again with metformin and a sulfonylurea. (diabetesincontrol.com)
  • A panel of speakers at a Novo Nordisk-sponsored symposium, held in conjunction with the American Diabetes Association meeting here, discussed the role of premixed and basal insulin analogs as the initiation regimen for these patients as well as the best agents to add on when more aggressive glycemic control becomes necessary. (medpagetoday.com)
  • Rapid-and long-acting insulin analogues offer little benefit relative to conventional insulins in terms of glycemic control or reduced hypoglycemia. (cmaj.ca)
  • 4 Insulin is indicated for all patients with type 1 diabetes and for patients with type 2 diabetes if adequate glycemic control cannot be achieved through exercise, diet or oral antidiabetic therapy. (cmaj.ca)
  • The goal of this study is to determine whether basal-bolus lispro and human analogue NPH insulin therapy, given twice daily with meals, would decreases postprandial hyperglycemia and improves clinical signs and glycemic control. (upenn.edu)
  • Basal-bolus insulin therapy is one of the most effective treatments for improving glycemic control to prevent the progression of diabetic microvascular complications. (springer.com)
  • This study was conducted to determine whether step-up insulin treatment with premixed insulin aspart-30/70 (BIAsp 30) or lispro-50/50 (Mix50) in Japanese patients with type 2 diabetes mellitus could achieve better glycemic control. (springer.com)
  • There are other insulin treatments with fewer daily injections which can achieve good glycemic control similar to that achieved with basal-bolus treatment. (springer.com)
  • it is important to maintain good glycemic control levels regardless of multiple or single insulin injections. (springer.com)
  • Recent studies demonstrated that twice-daily treatments with biphasic insulin aspart 70/30 (BIAsp 30) [ 5 , 6 ] and premixed insulin lispro-50/50 (Mix50) [ 3 ] could have equal effects on glycemic control and convey better quality of life than basal-bolus therapy in insulin-naïve patients. (springer.com)
  • This indicates that second phase secretion of insulin from the pancreas is more sensitive to the acute effects of ETOH than is first phase secretion. (nih.gov)
  • Basal secretion of insulin occurs without exogenous stimuli to maintain a certain concentration of insulin at all times, even while fasting. (brainscape.com)
  • The β-cells possess exquisite mechanisms regulating the secretion of insulin to ensure that the correct amount of insulin is released. (portlandpress.com)
  • Isx increased the expression and secretion of insulin in islets that made little insulin after prolonged ex vivo culture and increased expression of neurogenic differentiation 1 and other regulators of islet differentiation and insulin gene transcription. (pnas.org)
  • However, these agents do not replicate the pattern of basal and postprandial endogenous secretion of insulin. (cmaj.ca)
  • Therefore, we focused on the involvement of the OR system in the secretion of insulin from pancreatic β-cells. (nature.com)
  • In order to mimic the natural secretion of insulin in the body,commercially available insulin preparations are used in different ways(regimens) based on an individual's need and prevailing local practices.However it is important to evaluate these different regimens in a real lifesetting. (medindia.net)
  • This is because this regimen can stimulate the secretion of insulin from Islets of Langerhans at meal times. (springer.com)
  • Two injections of biphasic insulin aspart (70/30, is more effective then glargine. (diabetesincontrol.com)
  • Dr. Raskin, of the University of Texas, Dallas stated that, 'You can do better with two injections of a mix of intermediate and short acting insulin than you can with a single dose of glargine, a long-acting insulin,' particularly when baseline HbA1c values are high. (diabetesincontrol.com)
  • Study 2: BIAsp30 TID vs. basal-bolus (insulin glargine OD plus insulin glulisine TID) (n=24). (diabetesjournals.org)
  • Primary Objective: To demonstrate the superiority of the insulin glargine/lixisenatide fixed ratio combination (FRC) to insulin glargine by demonstrating change in glycosylated hemoglobin. (bioportfolio.com)
  • Switching to insulin glargine 300 U/mL: is duration of prior basal insulin therapy important? (bioportfolio.com)
  • To assess the impact of duration of prior basal insulin therapy on study outcomes in people with type 2 diabetes mellitus receiving insulin glargine 300 U/mL (Gla-300) or insulin glargine 100 U/mL (Gl. (bioportfolio.com)
  • Efficacy and Safety of MYL-1501D Versus Insulin Glargine in Patients With Type 1 Diabetes After 52 Weeks: Results of the Phase 3 INSTRIDE 1 Study. (bioportfolio.com)
  • Insulin glargine, a long-acting human insulin analogue, allows for once-daily basal use in patients with type 1 diabetes mellitus (T1DM). (bioportfolio.com)
  • MYL-1501D is a proposed insulin glargine biosimilar. (bioportfolio.com)
  • Effects of Insulin Treatment with Glargine or Premixed Insulin Lispro Programs in Type 2 Diabetes Mellitus Patients: A Meta-analysis of Randomized Clinical Trials. (bioportfolio.com)
  • The purpose of this study was to compare the efficacy and safety of intensive insulin therapy (premixed insulin lispro vs. insulin glargine) in patients with type 2 diabetes mellitus (T2DM). (bioportfolio.com)
  • Cost-Effectiveness of Insulin Degludec vs. Insulin Glargine U100 in Type 1 and Type 2 Diabetes Mellitus in a UK Setting. (bioportfolio.com)
  • It comes in three main types: short-acting (such as regular insulin), intermediate-acting (such as neutral protamine Hagedorn (NPH) insulin), and longer-acting (such as insulin glargine). (wikipedia.org)
  • Basal insulin can be taken as a once-daily dose, as in the case of insulin glargine or detemir, or taken twice daily, as in the case of insulin detemir and NPH insulin. (renalandurologynews.com)
  • Glargine and detemir insulins are reported to be peakless, although the latter may have a peak at 3 - 9 hours. (renalandurologynews.com)
  • The Glargine Treat-To-Target Trial compared the efficacy of glargine to NPH insulin. (renalandurologynews.com)
  • In this study, oral hypoglycemic therapy was continued, but insulin was added in the form of either glargine or NPH. (renalandurologynews.com)
  • The INITIATE study led by Dr. Raskin, published in Diabetes Care , showed that "you are better with two injections of mixed analog than one of basal," which in this study was Lantus (insulin glargine). (medpagetoday.com)
  • the long-acting agents insulin glargine and insulin detemir are marketed as basal insulins. (cmaj.ca)
  • In most studies, glycaemic control (HbA1C) with insulin glargine and detemir appears to be comparable to that achieved with daily or twice daily isophane (NPH) insulin. (slideserve.com)
  • This study aimed to demonstrate the non-inferiority of 50-week treatment with stepwise insulin intensification of basal-bolus insulin analogues [ insulin detemir (IDet) and aspart (IAsp)] versus biphasic insulin aspart 30 (BIAsp30) in insulin -naive type 2 diabetes mellitus (T2DM) patients not controlled by oral glucose -lowering drugs (OGLDs). (bvsalud.org)
  • Recombinant human types may duplicate exactly the human insulin protein sequence, or may be analogues with small differences in sequence. (thefreedictionary.com)
  • These are all synthetic copies (analogues) of human insulin and are clear in appearance. (mydr.com.au)
  • Both types of long-acting insulin are human insulin analogues (synthetic copies of human insulin) and are clear in appearance. (mydr.com.au)
  • Both products of the low-mix premixed insulin analogues aspart 30/70 and premixed insulin lispro 25/75 have comparable efficacy and safety as shown from the medical literature. (scirp.org)
  • http://www.springerlink.com/content/6lktug1r2exurq0j/?p=af5e2f613a0f4c6690f8fdc920f48bd6π=5, (2007) Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with Type 1 diabetes, Journal Diabetologia, volume 47, number 4 / April, 2004. (wikipedia.org)
  • Although insulin analogues are commonly prescribed for the management of diabetes mellitus, there is uncertainty regarding their optimal use. (cmaj.ca)
  • We conducted meta-analyses to compare the outcomes of insulin analogues with conventional insulins in the treatment of type 1, type 2 and gestational diabetes. (cmaj.ca)
  • We updated 2 earlier systematic reviews of the efficacy and safety of rapid-and long-acting insulin analogues. (cmaj.ca)
  • We searched electronic databases, conference proceedings and "grey literature" up to April 2007 to identify randomized controlled trials that compared insulin analogues with conventional insulins. (cmaj.ca)
  • We included 68 randomized controlled trials in the analysis of rapid-acting insulin analogues and 49 in the analysis of long-acting insulin analogues. (cmaj.ca)
  • There were insufficient data to determine whether insulin analogues are better than conventional insulins in reducing long-term diabetes-related complications or death. (cmaj.ca)
  • Long-term, high-quality studies are needed to determine whether insulin analogues reduce the risk of long-term complications of diabetes. (cmaj.ca)
  • Insulin analogues are modified human insulins developed to address this limitation. (cmaj.ca)
  • Systematic reviews of the insulin analogues have been published previously. (cmaj.ca)
  • 7 - 10 However, through our comprehensive search of the literature, we did not identify any reviews of long-acting insulin analogues in the management of type 1 diabetes or gestational diabetes. (cmaj.ca)
  • In this article, we provide an up-to-date, comprehensive systematic review and meta-analysis of outcomes associated with the use of rapid-and long-acting insulin analogues in type 1 and type 2 diabetes (adult and pediatric patients) and gestational diabetes. (cmaj.ca)
  • We based our current study on 2 health technology assessments of the insulin analogues from the Canadian Agency for Drugs and Technologies in Health (CADTH). (cmaj.ca)
  • Are insulin analogues better? (slideserve.com)
  • Rapid-acting insulin analogues have only a minor benefit over short-acting soluble insulin in most type 1 diabetes patients (Ô 0.1% HbA1C). (slideserve.com)
  • Are insulin analogues an unavoidable necessity for the treatment of type 2 diabetes in developing countries? (who.int)
  • ABSTRACT Despite their reported benefits in terms of glycaemic control, insulin analogues are expensive for patients in developing countries. (who.int)
  • RÉSUMÉ En dépit des avantages rapportés en termes de contrôle de la glycémie, les analogues de l'insuline sont coûteux pour les patients des pays en développement. (who.int)
  • Biphasic insulin aspart-30 reduces glycemic variability to a greater degree than insulin detemir: A randomized controlled trial of once-daily insulin regimens using continuous glucose monitoring. (bioportfolio.com)
  • Pharmacological profiles of biphasic insulin aspart 30/70 (BIAsp30) once-daily (OD), twice-daily (BID) and three-times-daily (TID) were compared with other insulin regimens in two crossover glucose-clamp studies in insulin-treated type 2 diabetes patients. (diabetesjournals.org)
  • OBJECTIVE -Rapid-acting insulin analogs in basal-bolus regimens can reduce nocturnal hypoglycemia, so it is conceivable that twice-daily biphasic insulin analogs might reduce hypoglycemia in patients with insulin-treated type 2 diabetes. (diabetesjournals.org)
  • In basal-bolus regimens, the inclusion of rapid-acting insulin analogs is associated with reduced nocturnal hypoglycemia relative to soluble human insulin ( 2 ). (diabetesjournals.org)
  • 58 mmol/mol) who had received background insulin regimens for at least 6 months preceding biphasic insulin 50/50 were compared against 12-month outcome data. (bmj.com)
  • There is a risk of weight gain and hypoglycemia, albeit at a much lower rate than traditional basal-bolus insulin regimens. (renalandurologynews.com)
  • More patients with type 2 diabetes on prandial insulin reach HbA1c targets compared with other insulin analogue regimens, according to the results of a meta-analysis. (pulsetoday.co.uk)
  • Highly active antiretroviral therapy (HAART) regimens, especially those including protease inhibitors have been shown to cause, in a high proportion of HIV-infected patients, a metabolic syndrome (lipodystrophy/lipoatrophy, dyslipidemia, type 2 diabetes mellitus, insulin resistance) that may be associated with an increased risk of cardiovascular disease. (eurekaselect.com)
  • Which insulin regimens are used? (slideserve.com)
  • Once completed A1chieve(R) will provide locally relevant information onthe effective use of modern insulins across different regimens. (medindia.net)
  • When insulin treatment is started in patients with type 2 diabetes mellitus (T2DM), there are many regimens that control serum glucose levels to a normal range. (springer.com)
  • Although these regimens are not always effective for all patients with (T2DM), a therapy with fewer insulin injections might be favored by physicians and patients. (springer.com)
  • BIAsp 70/30 (NovoLog Mix 70/30, Novo Nordisk) contains 30% soluble insulin aspart and 70% insulin aspart crystallized with protamine, which is used to control both fasting and postprandial hyperglycemia, , and his colleagues point out. (diabetesincontrol.com)
  • A 32-Week Randomized Comparison of Stepwise Insulin Intensification of Biphasic Insulin Aspart (BIAsp 30) Versus Basal-Bolus Therapy in Insulin-Naïve Patients with Type 2 Diabetes. (bioportfolio.com)
  • This 32-week, open-label, randomized, parallel-group, multinational trial aimed to compare the efficacy and safety of stepwise insulin intensification of biphasic insulin aspart 30 (BIAsp 30) relati. (bioportfolio.com)
  • We used a continuous glucose monitoring system (CGMS) and self-reported episodes to investigate differences in the frequency of low glucose values in patients with type 2 diabetes, using either biphasic insulin aspart 30 (BIAsp 30) or biphasic human insulin 30 (BHI 30). (diabetesjournals.org)
  • In this 6-week, open-label, parallel-group, controlled trial, 66 participants were randomized (1:1) to receive either IDegAsp or biphasic insulin aspart 30 (BIAsp 30) twice daily at the same total daily dose as pre-trial insulin. (unboundmedicine.com)
  • The aim of this clinical trial is to compare the 24-hour pharmacodynamics/ pharmacokinetics of biphasic insulin aspart 30 (BiAsp 30) thrice daily treatme. (bioportfolio.com)
  • To assess the financial consequences of different adoption rate of Biphasic Insulin Aspart (BIAsp) 30 instead of Biphasic Human Insulin (BHI) 30 for people with type 2 diabetes (T2DM) in Thailand from the payer's perspective. (bvsalud.org)
  • Objectives This study was conducted to determine whether there were differences in glycosylated hemoglobin (HbA1c), weight change, hypoglycemia occurrence, and treatment discontinuation between patients treated with biphasic insulin aspart 30 (BIAsp-30) or biphasic human insulin 30 (BHI-30) in UK general practice. (cf.ac.uk)
  • BIAsp-30 was associated with reduced hypoglycemia in insulin-naive patients with type 2 diabetes and lower rates of treatment discontinuation in insulin-experienced patients with type 2 diabetes. (cf.ac.uk)
  • In this open label study, 72 insulin-naïve patients with poorly controlled T2DM (HbA1c ≥8.4%), who had been taking oral antidiabetic drugs for at least 12 months, were randomized to receive BIAsp 30 or Mix50 therapy. (springer.com)
  • It demonstrated the efficacy of step-up treatment using premixed insulin BIAsp 30, and the practicality of once-daily injection of BIAsp 30 was shown. (springer.com)
  • Insuman comb contains a mix of two types of insulin, soluble insulin and isophane insulin. (netdoctor.co.uk)
  • Insuman comb 15 contains 15% soluble insulin and 85% isophane insulin. (netdoctor.co.uk)
  • Soluble insulin is known as short acting insulin. (netdoctor.co.uk)
  • Regular insulin, also known as neutral insulin and soluble insulin is a type of short-acting insulin. (wikipedia.org)
  • Overall hypoglycaemia: comparable effects with soluble insulin. (slideserve.com)
  • One vial contains 10 ml equivalent to 1000 IU of biphasic isophane insulin - 30 % soluble insulin / 70 % isophane insulin. (medicines.org.uk)
  • Humulin M3 is a sterile suspension of human insulin in the proportion of 30 % soluble insulin to 70 % isophane insulin. (medicines.org.uk)
  • The analog's biphasic activity, which serendipitously resembles current premixed formulations of soluble insulin and microcrystalline suspension, may be of particular utility in the developing world. (rcsb.org)
  • Biphasic insulin analogs allows delivery of both basal and prandial insulin in 1 injection that can be administered closer to mealtime, and produce greater reductions in the magnitude of postprandial glucose excursions than biphasic human insulin with less incidence of major hypoglycemia. (eurekaselect.com)
  • Fast-acting insulin aspart (faster aspart), commercialized under the trade name of Fiasp®, is insulin aspart in a new formulation aiming to mimic the physiologic prandial insulin release more closely. (bioportfolio.com)
  • METHODS: In an open-label, controlled, multicenter trial, we randomly assigned 708 patients with a suboptimal glycated hemoglobin level (7.0 to 10.0%) who were receiving maximally tolerated doses of metformin and sulfonylurea to receive biphasic insulin aspart twice daily, prandial insulin aspart three times daily, or basal insulin detemir once daily (twice if required). (ox.ac.uk)
  • The addition of biphasic or prandial insulin aspart reduced levels more than the addition of basal insulin detemir but was associated with greater risks of hypoglycemia and weight gain. (ox.ac.uk)
  • Patients with mostly post-prandial hyperglycemia will not be adequately controlled with basal insulin alone, and will require prandial insulin. (renalandurologynews.com)
  • Biphasic patients were 88% more likely to achieve the target of 7% or lower HbA1c level, and patients on prandial insulin and more than two times more likely, with an odds ratio of 2.07. (pulsetoday.co.uk)
  • Professor Dario Guigliano, professor of metabolic diseases at the Second University of Naples, Italy, concluded: 'A greater proportion of type 2 diabetic patients can achieve the less than 7% goal with biphasic or prandial insulin compared with basal insulin. (pulsetoday.co.uk)
  • Insulin injections act as a replacement for natural insulin and allow people with diabetes to achieve normal blood glucose levels. (netdoctor.co.uk)
  • These chemicals play an important role in maintaining normal blood glucose levels by triggering insulin release after a meal. (thefreedictionary.com)
  • β cells produce, store, and secrete insulin upon elevated blood glucose levels. (pnas.org)
  • Most patients with T2DM eventually require insulin if other medications fail to control their blood glucose levels adequately. (jaoa.org)
  • The sustained or second phase of insulin secretion persists as long as blood glucose levels remain elevated. (diabetesjournals.org)
  • In this study there was a forced titration of insulin, based on two preceding fasting blood glucose levels. (renalandurologynews.com)
  • In healthy individuals, any rise in blood glucose levels is rapidly countered by the release of insulin from the β-cells of the pancreas which in turn promotes the uptake and storage of the glucose in peripheral tissues. (portlandpress.com)
  • Pancreatic β-cells are typical secretory cells that release insulin in response to increased blood glucose levels, and thereby lower the level of glucose in the blood. (biologists.org)
  • Mean glycosylated haemoglobin (HbA1c %) was 8.1 (SD 2.7) in the biphasic group compared to 9.2 (SD 3.3) in the control group. (who.int)
  • Stepwise insulin intensification was performed at the end of 14, 26 and 38 weeks, depending on HbA1c values. (bvsalud.org)
  • Changes in HbA1c and weight were compared from baseline (the date of the first prescription for either insulin) through 180 days of follow-up using ANCOVA. (cf.ac.uk)
  • Results The overall mean HbA1c reduction at 12 months as a result of intensification and initiation with biphasic insulin 50/50 was 0.5% (5.5 mmol/mol) and 1.6% (17.5 mmol/mol), respectively. (bmj.com)
  • c) there is evidence that basal bolus insulin regimes reduce retinopathy progression versus bd regimes, even in type 2 patients, yet bd insulin regimes remain popular ((2): a 0.2%HbA1c retinopathy improvement with basal bolus regimes, equivalent to a 6% difference in retinopathy progression: older studies show up to a 300% difference. (bmj.com)
  • In both groups, 70% of participants achieved an HbA1c of 7.0%, but the proportion achieving this without hypoglycemia was higher with insulin detemir than with NPH insulin (26 vs. 16%, P = 0.008). (wikipedia.org)
  • In short, it was found that insulin detemir reduced HbA1c to target levels of 7.0% for 70% of patients, similar to human basal insulin, NPH, but without the same risk of hypoglycemia and with somewhat less weight gain. (wikipedia.org)
  • Thirty-two percent of study participants using exenatide reached target HbA1C of 7 percent or less and 18 percent of patients in the exenatide group achieved an HbA1c level of 6.5% compared to 9 percent in the biphasic insulin aspart group. (diabetesincontrol.com)
  • At 16 ± 2 weeks, a pre-breakfast injection of each type of insulin was added if HbA1c exceeded 7.4% (step 2). (springer.com)
  • TPA did not affect [Ca2+]i, but it increased insulin secretion after a 2 min lag. (biochemj.org)
  • Similar glucose control with basal-bolus regimen of insulin detemir plus insulin aspart and thrice-daily biphasic insulin aspart 30 in insulin-naive patients with type 2 diabetes: Results of a 50-week randomized clinical trial of stepwise insulin intensification. (bvsalud.org)
  • On this slide we can see the usual pattern of insulin intensification in T2DM, moving from lifestyle interventions, the addition of OADs such as metformin, through to a regimen combining the OAD therapies with basal insulin, which has become a popular way to initiate insulin. (slideshare.net)
  • Patients were stratified by treatment regimen, diabetes type, and insulin status (naive or experienced). (cf.ac.uk)
  • 1 , 2 There is no consensus about the most appropriate insulin regimen to be chosen, 3 but National Institute for Health and Care Excellence (NICE) guidelines recommend initiating insulin therapy with human neutral protamine Hagedorn insulin or a long-acting analog (basal insulin) injected at bedtime or twice daily according to the patient's need. (bmj.com)
  • Prompt initiation or intensification of insulin therapy and adherence to an insulin regimen will delay or prevent the development of diabetes complications. (ajmc.com)
  • WASHINGTON, June 15 â€" No matter what the insulin regimen patients with type 2 diabetes start on, eventually they will need intensification of therapy to combat disease progression. (medpagetoday.com)
  • Dr. Raskin noted a study by Edward J. Bastyr III, M.D., a senior clinical research physician at Eli Lilly in Indianapolis, published in Diabetes Care, that showed a significant improvement with a regimen that included Humalog (insulin lispro) compared with those that included NPH insulin or Glucophage (metformin). (medpagetoday.com)
  • Once patients reach a point where oral agents with basal insulin no longer provide adequate glucose control, clinicians need to overcome patient fears and get them on an intensified insulin regimen, according to Martin J. Abrahamson, M.D., an associate professor of medicine at Harvard Medical School. (medpagetoday.com)
  • To use insulin therapy most effectively, the regimen must be matched to the individual patient, considering his or her lifestyle needs and physical and mental capabilities, in addition to matching the body's physiological requirements. (diabetesjournals.org)
  • The progression from oral agents to combination therapy involving insulin, or insulin monotherapy, increasingly includes the use of insulin analogs. (diabetesjournals.org)
  • The data in this review discuss related recent patents and highlights the importance of biphasic insulin analogs in the management of type 2 diabetes mellitus. (eurekaselect.com)
  • Abbas A. Mansour, " Biphasic (Premix) Insulin Analogs in Type 2 Diabetes Mellitus", Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Under Re-organization) (2008) 2: 129. (eurekaselect.com)
  • This review shows that insulin analogs are cost-effective versus human insulins based on pharmacoeconomic models and retrospective database analyses. (ajmc.com)
  • To examine the cost-effectiveness of analogs versus human insulins, citing primarily studies conducted in the United States. (ajmc.com)
  • The lower incidence of hypoglycemia seen with analogs versus human insulins may help to overcome barriers to insulin acceptance among patients with type 2 diabetes mellitus. (ajmc.com)
  • Pharmacoeconomic modeling studies have consistently shown that insulin analogs provide gains in quality-adjusted life-years at costs well below accepted cost-effectiveness limits. (ajmc.com)
  • Retrospective analyses of healthcare databases have also shown cost-effectiveness for analogs versus human insulins, primarily because of lower inpatient care costs. (ajmc.com)
  • Treatment with insulin analogs has been demonstrated to be cost-effective versus other options over time and is an appropriate investment of healthcare dollars. (ajmc.com)
  • Treatment of type 1 and type 2 diabetes mellitus with insulin analogs is cost-effective versus other options over time. (ajmc.com)
  • In type 2 diabetes mellitus, the use of analogs can help to overcome some of the barriers to insulin use. (ajmc.com)
  • A separate study reported here supported basal-bolus therapy using insulin analogs rather than human insulins for type 1 diabetes patients as well. (medpagetoday.com)
  • Premixed insulin analogs may have some advantages in achieving this compared with human insulin products. (medpagetoday.com)
  • Between the two available long-acting insulin analogs, Levemir again has safety advantages. (medpagetoday.com)
  • Initiating insulin therapy in type 2 diabetes: a comparison of biphasic and basal insulin analogs. (bmj.com)
  • This "open" conformation not only rationalizes the inactivity of single-chain insulin (SCI) analogs (in which the A and B chains are directly linked), but also suggests that connecting (C) domains of sufficient length will bind the IR. (rcsb.org)
  • article{9325aeca-d7fd-40ff-917a-1af7c6108303, abstract = {Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. (lu.se)
  • Searches were conducted in PubMed to identify articles in the past 5 years with the name of any insulin analog plus the word cost or economic in the title or abstract. (ajmc.com)
  • Members of the bombesin family of peptides potently stimulate insulin release by HIT-T15 cells, a clonal pancreatic cell line. (biochemj.org)
  • Taken together, these data support the notion that Syntaxin 4-based SNARE complexes are essential for biphasic insulin granule fusion in pancreatic β-cells. (elsevier.com)
  • Spurlin, BA & Thurmond, DC 2006, ' Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic β-cells ', Molecular Endocrinology , vol. 20, no. 1, pp. 183-193. (elsevier.com)
  • In patients with established T2DM, insulin secretion is reduced because of progressive loss of pancreatic β-cell function. (jaoa.org)
  • Insulin is secreted by pancreatic β cells in response to glucose stimulation. (sciencemag.org)
  • this transcription factor functions in neuronal and pancreatic β-cell differentiation and is essential for insulin gene transcription. (pnas.org)
  • Pancreatic β cells play a unique role in glucose homeostasis by secreting insulin when the concentrations of glucose and other nutrients in the circulation rise ( 2 ). (pnas.org)
  • During the development of type 2 diabetes, pancreatic β cells become progressively unable to produce and secrete sufficient insulin to prevent hyperglycemia ( 1 , 3 , 4 ). (pnas.org)
  • Among the most important of these transcription factors are neurogenic differentiation 1 (NeuroD1, also known as BETA2), pancreatic and duodenal homeobox 1 (PDX-1), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), which activate the insulin gene promoter synergistically and are essential for glucose-stimulated insulin gene transcription. (pnas.org)
  • Patients showing factors predisposing to the development of diabetes mellitus (sedentary lifestyle, overweight or obesity, impaired fasting glucose or glucose intolerance, family history of diabetes, history of vascular disease, gestational diabetes, or at least one risk factor for metabolic syndrome) are at particular risk of drug-induced hyperglycemia, as some drugs can worsen pre-existing insulin resistance or pancreatic dysfunction. (springer.com)
  • Possible mechanisms of drug-induced hyperglycemia include alterations of insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells, and increase in glucose production. (springer.com)
  • An essential step triggering insulin secretion by pancreatic beta cells is closure of K ATP channels leading to the opening of voltage-dependent Ca 2+ channels [ 1 ]. (pubmedcentralcanada.ca)
  • Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. (nature.com)
  • These findings suggest that the OR system in pancreatic β-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism. (nature.com)
  • Pancreatic β-cells, which secrete insulin to regulate systemic glucose metabolism, receive nutritional information by sensing changes in circulating substances which reflect digested food. (nature.com)
  • Therefore, we hypothesized that an ectopic OR system in pancreatic β-cells, if present, would have a chemo-sensor function allowing sensing of circulating substances which reflect digested food and would be involved in regulating insulin secretion. (nature.com)
  • Under static incubation conditions, Syntaxin 4 (-/+) islets showed a 60% reduction in glucose-stimulated insulin secretion compared with wild-type islets. (elsevier.com)
  • Perifusion analyses revealed that Syntaxin 4 (-/+) islets secreted 50% less insulin during the first phase of glucose-stimulated insulin secretion and that this defect could be fully restored by the specific replenishment of recombinant Syntaxin 4. (elsevier.com)
  • Remarkably, islets isolated from transgenic mice that express 2.4-fold higher levels of Syntaxin 4 relative to wild-type mice secreted approximately 35% more insulin during both phases of insulin secretion, suggesting that increased Syntaxin 4 may be beneficial for enhancing biphasic insulin secretion in a regulated manner. (elsevier.com)
  • The mechanisms controlling these processes are complex and not fully understood but it is clear that the interaction of the β-cells with other β-cells in the islets is very important for their ability to develop the appropriate machinery for proper regulation of insulin secretion. (portlandpress.com)
  • Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets. (springer.com)
  • Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide. (semanticscholar.org)
  • Time and amplitude regulation of pulsatile insulin secretion by triggering and amplifying pathways in mouse islets. (semanticscholar.org)
  • Previous studies on isolated islets have demonstrated tight coupling between calcium (Ca 2+ ) influx and oxygen consumption rate (OCR) that is correlated with insulin secretion rate (ISR). (pubmedcentralcanada.ca)
  • Glucose- and Ca 2+ -mediated changes in OCR and ISR in isolated islets were compared with the time course of changes of plasma insulin concentrations observed during the progression to hyperglycaemia in a rat model of type-2 diabetes (the University of California at Davis type 2 diabetes mellitus [UCD-T2DM] rat). (pubmedcentralcanada.ca)
  • We have named this process, linking the Ca 2+ signal with insulin secretion, the 'Ca 2+ /metabolic coupling process (CMCP)' and have sought to characterise its defining features by quantifying metabolic and electrophysiological variables of isolated islets [ 13 , 14 ]. (pubmedcentralcanada.ca)
  • Premdas, F.H.5 Lipson, L.G.: Insulin release in aging: Dynamic response of isolated islets of Langerhans of the rat to D-glucose and D-glyceraldehyde. (springer.com)
  • By Eli Lilly these include: Humulin R (REGULAR human insulin injection [rDNA origin]) is a short-acting insulin that has a relatively short duration of activity as compared with other insulins. (wikipedia.org)
  • Short-acting insulin ( insulin neutral ) starts to work about half an hour after being injected, peaks from between 3 and 5 hours, and lasts for about 6-8 hours. (mydr.com.au)
  • Short-acting insulin is given 20-30 minutes before a meal. (mydr.com.au)
  • Hypurin Neutral (short-acting insulin obtained from the pancreas of cattle - bovine insulin). (mydr.com.au)
  • Intermediate-acting insulin is often used in conjunction with short-acting insulin. (mydr.com.au)
  • There is also a mixed insulin that contains a new type of ultra-long-acting basal insulin ( insulin degludec ) plus short-acting insulin aspart. (mydr.com.au)
  • Dear Dr. Martin Hovland, We learned from the literature that premixed insulins are short-acting insulin or rapid-acting insulin analogue mixed with intermediate-acting insulin in a fixed ratio, addressing FBG and PPBG in one injection. (scirp.org)
  • Premixed insulins are short-acting insulin or rapid-acting insulin analogue mixed with intermediate-acting insulin in a fixed ratio, addressing FBG and PPBG in one injection. (scirp.org)
  • Even I take short acting insulin(novorapid) when my sugar level goes beyond 300 but it doesn't make much difference. (medhelp.org)
  • The aim of this clinical trial is to investigate the safety (with emphasis on hypoglycaemia) after switching from long-acting insulin analogue/intermediat. (bioportfolio.com)
  • In the past, the only basal insulins available for use, were the intermediate acting insulins NPH and Lente and the long-acting insulin Ultralente. (renalandurologynews.com)
  • Long-acting insulin starts to work several hours after being injected and lasts for about 24 hours. (mydr.com.au)
  • Long-acting insulin is usually given once (or sometimes twice) daily, and should be given at the same time every day. (mydr.com.au)
  • It is important to monitor your blood glucose regularly and adjust your insulin dose as required. (netdoctor.co.uk)
  • Your insulin dose may also need adjusting during periods of emotional disturbance, or if you increase your physical activity or change your usual diet. (netdoctor.co.uk)
  • PATIENTS: A cohort of 25 patients with poor glycaemic control on a single dose of 100 units or more of lente insulin. (who.int)
  • Total mean insulin dose fell from 80 units (SD 12) to 61 units (SD 11) in the biphasic group, but increased in the control group from 82 units (SD 16) to 91 units (SD 13.1). (who.int)
  • AIDA is a freeware diabetic software simulator program of glucose-insulin action + insulin dose & diet adjustment in diabetes mellitus. (2aida.net)
  • If the preceding fasting blood sugar level was over 180 mg/dl, the insulin dose was increased by 8 units. (renalandurologynews.com)
  • If the fasting blood glucose level was between 120 - 140 mg/dl, the insulin dose was increased by 4 units. (renalandurologynews.com)
  • long-acting (or intermediate-acting) insulin is given once or twice a day as background insulin to maintain blood sugar levels - this is called a basal dose of insulin. (mydr.com.au)
  • Typically, the concentrations of insulin should increase or decrease by an increase or decrease in the administered dose. (scirp.org)
  • Dose is usually High doses of niacin can worsen insulin Are Vitamin Supplements Necessary for Diabetes Management? (amazonaws.com)
  • These data show that exenatide, without the inconvenience of dose titration, is a potential alternative to biphasic insulin aspart for the treatment of patients with type 2 diabetes not adequately treated with metformin and a sulfonylurea, commonly used oral antidiabetic agents. (diabetesincontrol.com)
  • trial sequential analyses showed sufficient evidence for a HbA 1c reduction of 0.5%, lower weight gain of 1 kg, and lower insulin dose of 5 U/day. (bmj.com)
  • Once the new user overcomes the problem of grasping the basic concepts of the program it is interesting to alter the inputs for insulin dose and carbohydrate intake and see an immediate change in the blood glucose level as a result of these changes. (2aida.org)
  • Insulin was formerly used in a psychiatric treatment called insulin shock therapy. (wikipedia.org)
  • Humulin R Regular U-500 (Concentrated) insulin human injection, USP (rDNA Origin) is a stronger concentration (500 units/mL) of Humulin R. Humulin 70/30 (70% human insulin isophane suspension, 30% human insulin injection [rDNA origin]) is a mixture insulin. (wikipedia.org)
  • It is an intermediate-acting insulin combined with the onset of action of Humulin Humulin 50/50 (50% human insulin isophane suspension, 50% human insulin injection [rDNA origin]) is a mixture insulin. (wikipedia.org)
  • Moreover, the site of injection, volume of injection, and the condition of the tissues into which the insulin is injected can alter its rate of absorption and peak action times, and exercising the limb which has been injected immediately after injection can increase the speed of absorption. (thefreedictionary.com)
  • Other problems of insulin therapy include insulin allergy , insulin resistance , insulin rebound due to the somogyi effect , and lipodystrophies or other localized tissue changes at injection sites. (thefreedictionary.com)
  • Lipodystrophies are localized manifestations of disordered fat metabolism at the sites of insulin injection. (thefreedictionary.com)
  • Measures that can help prevent lipodystrophies include (1) systematic rotation of injection sites, (2) warming insulin to room temperature before injection, (3) pinching the skin when injecting the insulin so that it is deposited between fat and muscle tissue, and (4) use of human insulin. (thefreedictionary.com)
  • A single evening or bedtime injection of basal insulin with continued use of oral agents lowers fasting blood sugars. (renalandurologynews.com)
  • To address both the fasting blood glucose (FBG) and post-prandial blood glucose (PPBG), the premix insulin formulations provide a combination of both rapid/short-acting and intermediate/long-acting insulins in a fixed ratio, in a single injection. (scirp.org)
  • derived principally by measuring the concentration of circulating insulin over time from the start of subcutaneous injection. (scirp.org)
  • After any insulin injection, the injection site should not be massaged. (medicines.org.uk)
  • Patients started treatment of a pre-dinner injection of each type of insulin (Step 1). (springer.com)
  • 7.4% after an additional 16 ± 2 weeks, a pre-lunch insulin injection was added (step 3). (springer.com)
  • Insulin initiation and intensification using IDet+IAsp was not inferior to BIAsp1-2-3 in insulin -naive patients with T2DM not controlled by OGLDs. (bvsalud.org)
  • Aims This study aims to examine the metabolic effects of intensification or initiation of insulin treatment with biphasic insulin 50/50, and determine the predictors of responders or non-responders to biphasic insulin 50/50. (bmj.com)
  • In type 2 diabetes mellitus, prompt initiation or intensification of insulin therapy could save costs by delaying the development of complications. (ajmc.com)
  • Insulin intensification is a problem," said symposium moderator Malcolm Nattrass, M.B., Ph.D., a consultant diabetologist at the University Hospital Birmingham and Selly Oak Hospital in England. (medpagetoday.com)
  • Humalog Mix 25 vials, Humalog Mix 25 cartridges (for use with Autopen Classic or HumaPen pens) and Humalog Mix 25 KwikPen prefilled pens all contain biphasic insulin lispro. (netdoctor.co.uk)
  • Humalog Mix25 contains a mix of two types of insulin, insulin lispro (25 per cent) and insulin lispro protamine (75 per cent). (netdoctor.co.uk)
  • Together, the combination is called biphasic insulin lispro. (netdoctor.co.uk)
  • Insulin lispro is known as a fast-acting insulin. (netdoctor.co.uk)
  • Insulin lispro protamine is known as an intermediate-acting insulin. (netdoctor.co.uk)
  • The ultra-short acting insulins lispro and aspart are also available in a biphasic form. (mydr.com.au)
  • The treatment with premixed aspart 30 was non-inferior to treatment with premixed insulin lispro 25. (scirp.org)
  • Boluses of rapidly and short acting insulins (such as lispro insulin) in the example below are given at the time of meals in addition to a longer acting insulin, such as NPH, which provides basal therapy. (upenn.edu)
  • Study expenses, including the price of the lispro insulin, will be covered by the researchers. (upenn.edu)
  • Insuman comb preparations contain these two types of insulin in varying proportions. (netdoctor.co.uk)
  • There are several different types of insulin, usually classified by their onset and duration of action. (thefreedictionary.com)
  • There are a variety of types of insulin and ways to give it, including injections, pens and pumps. (mydr.com.au)
  • There are different types of insulin available to manage diabetes. (mydr.com.au)
  • These days, most types of insulin are synthetic (created in a laboratory), but there are some that are extracted from the pancreas of animals. (mydr.com.au)
  • Mixed insulin (also called biphasic premixed or combination insulin) is a premixed combination of 2 different types of insulin. (mydr.com.au)
  • The numbers written after the brand name show the mix of the 2 types of insulin. (mydr.com.au)
  • your individual reaction to the different types of insulin available. (mydr.com.au)
  • There are differences between these three types of insulin in how high they get the insulin and how fast they get it there," he said. (medpagetoday.com)
  • Standard' mode provides for two different types of insulin which can be user selected from a variety of different insulins whose action profiles are pre-stored. (mendosa.com)
  • Low blood sugar (hypoglycaemia) is a potential side effect of insulin therapy. (netdoctor.co.uk)
  • The aim of this trial is to investigate the efficacy and safety of biphasic insulin aspart 30 as start insulin in subjects with type 2 diabetes failing OAD therapy. (clinicaltrials.gov)
  • First line therapy against insulin hypersensitivity reactions include symptomatic therapy with antihistamines. (wikipedia.org)
  • A lot of people require insulin therapy to manage their blood sugar levels and keep them within a target range. (wikipedia.org)
  • The problem of either too much or too little insulin is always a potential hazard for the person on insulin therapy. (thefreedictionary.com)
  • Inhaled diabetes drug is effective in study and inhaled insulin therapy was safe for diabetes patients. (emaxhealth.com)
  • Comparative analyses were carried out on subgroups of 237 patients initiating insulin therapy with biphasic insulin 50/50, and between users of the Humalog Mix50 (HM50) versus Insuman Comb 50 (IC50). (bmj.com)
  • Insulin therapy has been the mainstay of therapy for patients with type 2 diabetes mellitus for the past 90 years. (jaoa.org)
  • This trend is likely to continue as new formulations are developed to more closely mimic physiologic insulin secretion and to provide patients who have diabetes with more convenient options for integrating this therapy into their lifestyle. (jaoa.org)
  • The present article reviews how the role of insulin continues to evolve, from its earlier use in the treatment paradigm (even at first diagnosis) to its role in combination therapy with incretin-based therapies, as well as new formulations that provide more-convenient forms of insulin replacement therapy. (jaoa.org)
  • As a result of improvements in health care and increases in longevity, patients are more likely to require insulin therapy at some point during the progression of T2DM. (jaoa.org)
  • With advances in insulin therapy still occurring, it is well worth keeping up to date on trends in the use of this powerful glucose-lowering agent. (jaoa.org)
  • 1 Insulin replacement therapy lets patients know that a key component of their natural glucose-regulating system is being restored. (jaoa.org)
  • When insulin replacement therapy was introduced more than 90 years ago, 2 it was a lifesaving option for patients with type 1 diabetes mellitus (T1DM), even though the formulations used were relatively crude. (jaoa.org)
  • 2 The present review article discusses initiation of insulin replacement therapy at the time of diagnosis, basal insulin therapy used in combination with incretin therapy, and second-generation basal insulin analog therapy, using a case study to demonstrate clinical application. (jaoa.org)
  • Insulin therapy improves blood glucose control, but this is usually accompanied by weight gain and the attendant risk of hypoglycemia. (renalandurologynews.com)
  • Adding a basal insulin to oral hypoglycemic therapy is relatively simple and has the advantage of easing a patient into insulin therapy slowly. (renalandurologynews.com)
  • All patients with type 2 diabetes who have not achieved goal A1c and who are on maximal oral hypoglycemics and/or incretin therapy should be started on insulin. (renalandurologynews.com)
  • It is critical that insulin therapy not be delayed. (renalandurologynews.com)
  • Patients with high fasting blood sugars are good candidates for adding basal insulin therapy to their oral agents. (renalandurologynews.com)
  • The addition of basal insulin therapy to oral hypoglycemic treatment is relatively simple. (renalandurologynews.com)
  • Basal and premixed insulin have been widely used for insulin therapy of type 2 diabetes mellitus (T2DM) in China. (frontiersin.org)
  • and if these fail, then to start anti-diabetic agents at or soon after the diagnose and/or insulin therapy ( 3 , 4 ). (frontiersin.org)
  • Weight gain is a common side effect of insulin therapy. (diabetesincontrol.com)
  • Explain to interested patients that insulin therapy may need to be carefully adjusted. (medpagetoday.com)
  • Initially moving to insulin therapy from oral antidiabetic agents alone can be accomplished with premixed human or analog insulin. (medpagetoday.com)
  • He recommended Levemir (insulin detemir) as a long-acting basal insulin to initiate insulin therapy for patients with type 2 diabetes. (medpagetoday.com)
  • After a thorough discussion of the morbidity associated with poorly controlled diabetes, he agrees to initiate insulin therapy. (diabetesjournals.org)
  • A major challenge for primary care physicians when initiating insulin therapy is choosing when to use each of the many insulins available today-rapid-acting, short-acting, intermediate-acting, long-acting, or premixed insulins ( Table 1 ). (diabetesjournals.org)
  • These are the physiological mechanisms that physicians attempt to replicate with exogenous insulin therapy. (diabetesjournals.org)
  • Many algorithms have been generated for initiating insulin therapy, and this can be confusing to general practitioners. (diabetesjournals.org)
  • Patients whose blood glucose is greatly improved, e.g. by intensified insulin therapy, may lose some or all of the warning symptoms of hypoglycaemia and should be advised accordingly. (medicines.org.uk)
  • Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes: results of a 6-month, randomized, comparative trial. (bmj.com)
  • Spanning 28 countries across 4 continents and involving more than 3300physicians, A1chieve(R) is set to be the world's largest observational studyin insulin therapy. (medindia.net)
  • The two most important components of therapy for diabetes mellitus (DM) in dogs are administration of insulin and dietary management. (upenn.edu)
  • Basal-bolus therapy is an effective form of combination insulin therapy which mimics biphasic physiologic insulin secretion. (upenn.edu)
  • The goal of the bolus component of therapy is to mimic phase one of insulin secretion and to address postprandial hyperglycemia. (upenn.edu)
  • Atrophy of the tissues is relatively harmless, but hypertrophy can cause malabsorption of the insulin and a possible misdiagnosis of insulin resistance . (thefreedictionary.com)
  • Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats," Journal of Clinical Investigation , vol. 104, no. 4, pp. 447-457, 1999. (hindawi.com)
  • Vascular insulin resistance in prehypertensive rats: role of PI3-kinase/Akt/eNOS signaling," European Journal of Pharmacology , vol. 628, no. 1-3, pp. 140-147, 2010. (hindawi.com)
  • We will discuss the regulation of renal sodium transport by insulin and its roles in the pathogenesis of hypertension in insulin resistance. (hindawi.com)
  • Obesity is, at the same time, closely related to hyperinsulinemia and insulin resistance [ 2 ]. (hindawi.com)
  • While the precise mechanism of hypertension in insulin resistance remains to be clarified, the activation of sympathetic nerve system, the disorders dysregulation of central nerve system including leptin, and the activation of renin-angiotensin system are generally thought to be involved [ 1 ]. (hindawi.com)
  • However, the influence of insulin on blood pressure may be altered in insulin resistance. (hindawi.com)
  • For example, the insulin-induced vasodilation is impaired due to defects in PI3-kinase signaling in insulin resistance [ 8 , 9 ]. (hindawi.com)
  • Moreover, several recent data suggest that the insulin-induced enhancement of renal sodium reabsorption is preserved or even enhanced in insulin resistance [ 10 - 12 ]. (hindawi.com)
  • showed that, in obese subjects with insulin resistance, urinary sodium excretion was decreased by insulin similarly as in nonobese subjects [ 11 ]. (hindawi.com)
  • These considerations support a significant role of insulin-stimulated renal sodium transport in the pathogenesis of hypertension in insulin resistance. (hindawi.com)
  • In the liver of these animals , however, a significant decrease of IRS-1 mRNA was detected after 14 days of MMI treatment , a mechanism probably involved in the insulin resistance that occurs in hypothyroidism . (bvsalud.org)
  • 4 Plasma glucose levels increase as insulin deficiency and insulin resistance reduce normal insulin activity, leading to diminished stimulation of peripheral glucose uptake and decreased inhibition of hepatic glucose production. (jaoa.org)
  • Treatments and Practitioners for Insulin Nitric Oxide Erectile Dysfunction Diabetes Resistance and PCOS. (amazonaws.com)
  • IGR-insulin glucose ratio QUICKI-quantitative insulin sensitivity check index HOMAIR- homeostatic model analysis for insulin resistance. (amazonaws.com)
  • Drug-induced hyperglycemia is often benign and reversible within days with some drugs but may take longer if it is secondary to weight gain or peripheral insulin resistance. (springer.com)
  • They almost always have resistance to the peripheral action of insulin (5, 6), while insulin secretion could be normal (4,7), increased (8,9) or decreased (3). (springer.com)
  • Hendler, E.S Wahren, J.: Insulin resistance in uremia. (springer.com)
  • Reaven, G.M.: Evaluation of insulin resistance in patients with primary hyperparathyroidism. (springer.com)
  • A method for qualifying insulin secretion and resistance. (springer.com)
  • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. (upenn.edu)
  • Ask D'Mine: Is Insulin Resistance Linked to BPA Exposure? (medworm.com)
  • Insulin Initiation : When We should Start with Basal Insulin? (slideshare.net)
  • The initiation of insulin is an important stage in the management of type 2 diabetes. (diabetesjournals.org)
  • 9%. 9 In this article, we discuss an approach to initiation and titration of insulin in patients in the primary care setting. (diabetesjournals.org)
  • CONCLUSIONS: A single analogue-insulin formulation added to metformin and sulfonylurea resulted in a glycated hemoglobin level of 6.5% or less in a minority of patients at 1 year. (ox.ac.uk)
  • Insulin detemir is a long-acting human insulin analogue for maintaining the basal level of insulin. (wikipedia.org)
  • It is an insulin analogue in which a fatty acid (myristic acid) is bound to the lysine amino acid at position B29. (wikipedia.org)
  • Changes in strength, brand (manufacturer), type (soluble, isophane, mixture), species (animal, human, human insulin analogue), and/or method of manufacture (recombinant DNA versus animal-source insulin) may result in the need for a change in dosage. (medicines.org.uk)
  • This study in Jordan aimed to compare the effectiveness and adverse events of premixed human insulin (BHI30) versus premixed insulin analogue (BIAsp30) in patients with type 2 diabetes. (who.int)
  • In model 1), the so-called, readily releasable pool consists of SGs that are already docked with the plasma membrane and are released immediately upon glucose stimulation, thereby creating the first rapid phase of insulin secretion ( 10 ). (pnas.org)
  • The first phase of insulin secretion consists of a large and rapid increase and decrease in insulin secretion, and the second phase maintains a smaller magnitude plateau. (upenn.edu)
  • People with diabetes have a deficiency or absence of a hormone manufactured by the pancreas called insulin. (netdoctor.co.uk)
  • The effect of ethanol (ETOH) on glucose-stimulated insulin secretion was studied using: (1) an in vitro isolated pancreas perfusion system, and (2) an in vivo preparation utilizing unrestrained, unanesthetized rats with indwelling jugular and aortic catheters. (nih.gov)
  • ETOH exposure in vitro resulted in a decrease in glucose-stimulated insulin secretion from the perfused rat pancreas. (nih.gov)
  • Regular insulin can be made from the pancreas of pigs or cows. (wikipedia.org)
  • Insulin is an endogenous hormone, which is produced by the pancreas. (wikipedia.org)
  • Initially, the only way to obtain insulin for clinical use was to extract it from the pancreas of another creature. (wikipedia.org)
  • it may be bovine or porcine in origin (prepared from the pancreas of the animals) or a recombinant human type, although insulin of bovine origin is no longer available in the United States. (thefreedictionary.com)
  • Insulin is produced by the β-cells of the pancreas to clear glucose from the blood and allow uptake of glucose by the muscle, fat, and liver. (diabetesjournals.org)
  • The pancreas makes a small amount of insulin, termed "basal insulin," even in the fasting state to suppress catabolism of muscle, fat, and other body tissues and regulate hepatic glucose production. (diabetesjournals.org)
  • Type 1 and type 2 diabetes each have similarities in that both types of diabetes involve insulin from the pancreas not working properly as it should. (amazonaws.com)
  • But treatment with biphasic insulin was associated with a 34% greater incidence of hypoglycaemia and weight gain. (pulsetoday.co.uk)
  • type 2 diabetes not optimally controlled on once or twice daily insulin with or without metformin. (bioportfolio.com)
  • The aim of the trial is to compare two NN5401 formulations with each other and with biphasic insulin aspart 30, all in combination with metformin in insu. (bioportfolio.com)
  • The aim of this trial is to evaluate the efficacy of metformin plus biphasic insulin aspart or insulin NPH on blood glucose control in subjects with type 2 diabetes. (clinicaltrials.gov)
  • Results from a study indicating that exenatide improves blood sugar levels as effectively as biphasic insulin aspart 30/70 (NovoMix 30(R), NovoNordisk) for people with type 2 diabetes failing to achieve acceptable blood sugar control on both metformin and a sulfonylurea. (diabetesincontrol.com)
  • The trial was designed to determine if exenatide can be used as safely and effectively as biphasic insulin aspart in patients with type 2 diabetes inadequately treated with metformin plus a sulfonylurea. (diabetesincontrol.com)
  • Objectives To compare the benefits and harms of metformin and insulin versus insulin alone as reported in randomised clinical trials of patients with type 2 diabetes. (bmj.com)
  • Review methods Two authors independently screened titles and abstracts for randomised clinical trials comparing metformin and insulin versus insulin alone (with or without placebo) in patients with type 2 diabetes, older than 18 years, and with an intervention period of at least 12 weeks. (bmj.com)
  • Metformin and insulin versus insulin alone did not significantly affect all cause mortality (relative risk 1.30, 95% confidence interval 0.57 to 2.99) or cardiovascular mortality (1.70, 0.35 to 8.30). (bmj.com)
  • In a fixed effect model, but not in a random effects model, severe hypoglycaemia was significantly more frequent with metformin and insulin than with insulin alone (2.83, 1.17 to 6.86). (bmj.com)
  • Conclusions There was no evidence or even a trend towards improved all cause mortality or cardiovascular mortality with metformin and insulin, compared with insulin alone in type 2 diabetes. (bmj.com)
  • Metformin is a glucose lowering drug that, among other mechanisms, is supposed to work by enhancing insulin action mainly in the liver. (bmj.com)
  • 2 Because of disease progression, a substantial proportion of these patients eventually end up on insulin, at which point doctors are recommended to continue metformin use. (bmj.com)
  • I added metformin to my regamine and it helps with the breakdown of my insulin. (medhelp.org)
  • Isophane insulin is known as intermediate acting insulin. (netdoctor.co.uk)
  • It is an intermediate-acting insulin combined with the onset of action of Humulin R. In UK these include: Actrapid Humulin S Insuman Rapid "insulin regular human (OTC) - Humulin R, Novolin R". Archived from the original on 16 December 2014. (wikipedia.org)
  • Background Premixed, or biphasic, insulins containing varying proportions of rapid- and intermediate-acting insulin components have been developed to limit the number of daily injections for patients who require both prandial and basal insulin injections. (cf.ac.uk)
  • Intermediate-acting insulin ( isophane insulin ) is cloudy in appearance. (mydr.com.au)
  • Intermediate-acting insulin is usually given once or twice a day. (mydr.com.au)
  • All of these 'pre-mixed' insulins are bi-phasic preparations - containing a pre-specified ratio of short- to intermediate-acting insulin. (mendosa.com)
  • Activation of the KATP channel-dependent pathway results in exocytosis of an immediately releasable pool that is responsible for the first phase of glucose-stimulated insulin release. (nih.gov)
  • Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes. (lu.se)
  • Numerous overexpression studies have recently implicated Syntaxin 4 as an effector of insulin secretion, although its requirement in insulin granule exocytosis is unknown. (elsevier.com)
  • However, only a small percentage of insulin SGs undergo exocytosis upon glucose stimulation ( 6 ). (pnas.org)
  • On the level of insulin SGs, our understanding of insulin secretion has been shaped by two basic concepts: 1) the recruitment of SG pools defined by their spatial confinement in the cell and 2) the higher probability of young SGs for exocytosis. (pnas.org)
  • Intracellular calcium signaling was unaffected by PKA activation, suggesting that the effects of PKA on acute-phase insulin secretion are mediated by the phosphorylation of proteins involved in β-cell exocytosis. (diabetesjournals.org)
  • During the first phase of glucose-stimulated insulin secretion, ∼0.4% of insulin granules undergo exocytosis ( 4 ). (diabetesjournals.org)
  • Although many efforts have been made to clarify the molecular mechanisms of glucose-induced insulin exocytosis, knowledge about glucose-induced endocytosis is still limited. (biologists.org)
  • Insulin is being used earlier in the management of type 2 diabetes to achieve tighter glucose targets, but weight gain and, in particular, hypoglycemia remain important barriers to the success of treatment ( 1 ). (diabetesjournals.org)
  • Switching unit-to-unit from basal or pre-mix insulin to IDegAsp seems not to be associated with any concerns related to hypoglycemia or general safety in Japanese patients with type 2 diabetes. (unboundmedicine.com)
  • Compared with NPH insulin, the risk for all hypoglycemia with insulin detemir was reduced by 47% (P (wikipedia.org)
  • Insulin must be precisely released to avoid both postprandial hyperglycemia from insufficient or delayed insulin release or hypoglycemia from secretion of too much insulin. (diabetesjournals.org)
  • People with Type 1 diabetes need to have injections of insulin to control the amount of glucose in their bloodstream. (netdoctor.co.uk)
  • Your doctor or diabetes specialist will teach you how to administer your insulin injections correctly. (netdoctor.co.uk)
  • You should measure your blood sugar levels every day when using insulin injections. (netdoctor.co.uk)
  • People with type one diabetes need to have injections of insulin to control the amount of glucose in their bloodstream. (netdoctor.co.uk)
  • INTRODUCTION: Improved glycaemic control is possible with the use of multiple injections of premixed insulin. (who.int)
  • There is significant clinician inertia towards starting insulin, which is partly related to the complexity of insulin use and patient reluctance to using injections. (renalandurologynews.com)
  • It is possible that similar effects may also be observed with biphasic insulin preparations. (diabetesjournals.org)
  • Whichever insulin type is chosen, this may be superseded if a particular case scenario is then selected which uses the other type of insulin preparations. (mendosa.com)
  • Care should be taken when injecting any Humulin insulin preparations to ensure that a blood vessel has not been entered. (medicines.org.uk)
  • Humulin Mixture formulation is a ready-made defined mixture of soluble and isophane insulin designed to avoid the need for the patient to mix insulin preparations. (medicines.org.uk)
  • We compared the efficacy of insulin detemir and biphasic insulin aspart-30 given in the morning as an add-on to oral hypoglycemic agents (OHAs) in type 2 diabetic patients. (bioportfolio.com)
  • Insulin degludec/insulin aspart lowers fasting plasma glucose and rates of confirmed and nocturnal hypoglycaemia independent of baseline HbAlevels, disease duration or BMI: A pooled meta-analysis of phase 3 studies in patients with type 2 diabetes. (bioportfolio.com)
  • The present exploratory trial investigated the safety of switching unit-to-unit from twice-daily basal or pre-mix insulin to twice-daily IDegAsp in Japanese patients with type 2 diabetes. (unboundmedicine.com)
  • CONCLUSION: Patient mixed and administered biphasic insulin on a twice daily basis is feasible, acceptable to patients, results in better glycaemic control and affords better patient satisfaction. (who.int)
  • In this open-label multicentre, multinational, randomized, parallel- arm treat-to-target trial, 403 insulin -naive patients with T2DM in four African countries were randomized to either an IDet+IAsp (n = 200) or BIAsp1-2-3 (n = 203) treatment group. (bvsalud.org)
  • The difference between insulins was not significant in insulin-experienced patients with type 1 diabetes. (cf.ac.uk)
  • Methods A cohort of 2183 patients ≥18 years with diabetes, newly treated with biphasic insulin 50/50 between January 2000 and May 2012, were sourced from UK General Practices via The Health Improvement Network (THIN) database. (bmj.com)
  • 30) patients with insulin-treated diabetes. (bmj.com)
  • These findings could form a basis for a randomized clinical trial on obese insulin-treated patients with diabetes. (bmj.com)
  • Patients with T2DM are insulin resistant, have relatively low insulin production, or have both characteristics. (jaoa.org)
  • Other means of enhancing delivery of insulin to patients are also discussed. (jaoa.org)
  • However, most patients eventually lose control of diabetes and require insulin. (renalandurologynews.com)
  • The use of insulin is usually postponed and patients experience a prolonged period of hyperglycemia. (renalandurologynews.com)
  • Patients on exenatide lost weight, while insulin patients gained weight. (diabetesincontrol.com)
  • These Patients on exenatide lost an average of 2.5 kilograms (5.5 pounds), while those receiving biphasic insulin aspart gained an average of 2.9 kilograms (6.4 pounds). (diabetesincontrol.com)
  • Weight gain in the biphasic insulin aspart: On average, patients treated with insulin gained 2.9 kilograms (6.4 pounds). (diabetesincontrol.com)
  • The study by Julio Rosenstock, M.D., a clinical professor of medicine at the University of Texas Southwestern Medical School in Dallas, presented at last year's ADA meeting, used both drugs according to package insert directions as an add-on to oral antidiabetic agents in insulin-naïve patients with type 2 diabetes. (medpagetoday.com)
  • Both agents reached and maintained patients at an identical hemoglobin A1C, which shows that "insulin is insulin is insulin," Dr. Ratner said. (medpagetoday.com)
  • Glucose intolerance is, therefore, usually encountered in uremic patients in whom both impaired tissue sensitivity to insulin and impaired secretion of the hormone co-exist (5,10). (springer.com)
  • For the treatment of patients with diabetes mellitus who require insulin for the maintenance of glucose homeostasis. (medicines.org.uk)
  • Some patients taking human insulin may require a change in dosage from that used with animal-source insulins. (medicines.org.uk)
  • A few patients who experienced hypoglycaemic reactions after transfer to human insulin have reported that the early warning symptoms were less pronounced or different from those experienced with their previous animal insulin. (medicines.org.uk)
  • Adjustment of insulin dosage may also be necessary if patients change their level of physical activity or change their usual diet. (medicines.org.uk)
  • Self-monitoring of blood glucose in patients with type 2 diabetes who are not using insulin. (bmj.com)
  • La présente étude en Jordanie visait à comparer l'efficacité de l'insuline humaine prémélangée (BHI30) à celle de l'analogue de l'insuline prémélangé (BIAsp30) ainsi que les événements indésirables pour deux substances chez des patients atteints de diabète de type 2. (who.int)
  • One definite message is that diabetes education of both patients and healthcare workers needs to go beyond broad guidelines and that a sound understanding of insulin and carbohydrate interaction is fundamental. (2aida.org)
  • Initial release of insulin in response to ingestion of food is termed "first-phase insulin secretion" . (brainscape.com)
  • Glucose-stimulated insulin release is biphasic, characterized by an initial acute burst of insulin secretion followed by a sustained suprabasal release of insulin ( 1 , 2 ). (diabetesjournals.org)
  • Previous studies demonstrated the co-formulation of insulin degludec (IDeg)/insulin aspart (IAsp) 'IDegAsp' offers lower rates of hypoglycaemia with smaller changes in weight compared with basal-bolus. (bioportfolio.com)
  • NovoMix 30 (insulin aspart). (mydr.com.au)
  • Right now, I am taking Novomix 30 (biphasic insulin aspart) and Volibo 0.2 (twice in a day-breakfast and Dinner time). (medhelp.org)
  • The objective of the study is to investigate the effect and safety of continously basal delivered Insulin Aspart given by a pump versus once daily inject. (bioportfolio.com)
  • Insulin is instrumental in managing T2DM, which is a complex, multihormonal, and progressive chronic disease. (jaoa.org)
  • The aim of this study is to compare the sustained efficacy of basal and premixed insulin therapies in T2DM outpatients with insulin monotherapy. (frontiersin.org)
  • A total of 49,119 T2DM outpatients on basal ( n = 11,967) or premixed insulin ( n = 37,152) monotherapy were included in the final analyses. (frontiersin.org)
  • 7.0%) than basal insulin monotherapy for Chinese T2DM outpatients in daily. (frontiersin.org)
  • Biphasic insulin aspart 30 treatment for people with type 2 diabetes: a budget impact analysis based in Thailand. (bvsalud.org)
  • This long-term clinical trial is the second study conducted at European clinical centers demonstrating that exenatide can control blood sugar as effectively as insulin. (diabetesincontrol.com)
  • The most common adverse event for exenatide was nausea (33.2 percent exenatide, 0.4 percent biphasic insulin aspart), which was generally mild-to-moderate and tended to decrease in frequency and severity over time. (diabetesincontrol.com)
  • In response to sustained hyperglycemia, PKA activity potentiated both acute and sustained insulin release. (diabetesjournals.org)
  • Insulin should be added as soon as there is a trend towards hyperglycemia. (renalandurologynews.com)
  • The choice of insulin depends on the type of hyperglycemia experienced by the patient. (renalandurologynews.com)
  • A recent study, by the PennVets diabetes group found that some well-regulated diabetic dogs treated with NPH insulin and W/D develop postprandial hyperglycemia, as in the example below. (upenn.edu)
  • Weight Gain In addition, the safety and efficacy of insulin detemir (Levemir®) in real life clinical practice was evaluated in the A1chieve study. (wikipedia.org)
  • ISPAD Clinical Practice Consensus Guideline: Diabetic ketoacidosis in the time of COVID-19 and resource-limited settings-role of subcutaneous insulin. (childrenshospital.org)
  • The postprandial glucose concentration falls rapidly in response to insulin, reaching baseline levels 90-120 minutes after eating. (brainscape.com)
  • This strategy covers the basal glucose levels and allows endogenous insulin to cover the postprandial glucose. (medpagetoday.com)
  • A type of insulin that is a mixture of intermediate- and fast-acting insulin. (medindia.net)
  • Your doctor and diabetes educator can recommend the most suitable type of insulin and delivery device for you. (mydr.com.au)
  • This type of insulin is injected immediately before meal times and is also used in insulin pumps. (mydr.com.au)
  • Pre-mixed' mode provides a single type of insulin which can be user selected from a range of different insulins whose actions profiles have been pre-stored. (mendosa.com)
  • Physiologic insulin secretion consists of a constant basal level of insulin secretion and prandial secretion associated with ingestion of food. (brainscape.com)
  • The goal of insulin treatment is to mimic the biphasic mode of physiologic insulin secretion. (upenn.edu)
  • The aim of this study was to identify the intracellular messengers involved in this biphasic secretory response. (biochemj.org)
  • However, pretreating cells with ionomycin decreased the effects of bombesin on both [Ca2+]i and insulin release, suggesting that elevation of [Ca2+]i was instrumental in the secretory response to this peptide. (biochemj.org)
  • We present here a transgenic pig model that allows the in vivo fluorescent labeling of age-distinct insulin secretory granule pools, hence providing a close-to-life readout of insulin turnover. (pnas.org)
  • The probability for insulin secretory granules to undergo fusion with the plasma membrane or being degraded is correlated with their age. (pnas.org)
  • To overcome this translational gap and study insulin secretory granule turnover in vivo, we have generated a transgenic pig model with the SNAP-tag fused to insulin. (pnas.org)
  • This model may provide unprecedented insights into the in vivo insulin secretory granule behavior in an animal close to humans. (pnas.org)
  • Each β cell contains several thousand insulin secretory granules (SGs) ( 4 , 5 ). (pnas.org)
  • These mechanisms involve tight control of the movement of insulin containing secretory vesicles within the β-cells, initially preventing most vesicles being able to move to the plasma membrane. (portlandpress.com)
  • In one study by Kjeld Hermansen, M.D., of Aarhus University Hospital, in Aarhus, Denmark, published in Diabetes Care , NovoLog Mix (biphasic insulin aspart 70/30) appeared superior to Humalog or its human counterpart Novolin. (medpagetoday.com)
  • Insuman comb pre-filled SoloStar pens, cartridges (for use with clikSTAR or Autopen 24 pens) and vials all contain human biphasic isophane insulin. (netdoctor.co.uk)
  • Study 1: BIAsp30 OD, BID and TID vs. biphasic human insulin 30/70 (BHI30) OD (n=24). (diabetesjournals.org)
  • it needs to be given 30 and 45 minutes before meals ,and has an inappropriately prolonged duration of action, while the longer-acting zinc formulations do not have the long duration of action required of a basal insulin , even with biphasic human insulin. (eurekaselect.com)
  • Due to response similarities the rat model may be of considerable value to study the effects of ETOH on stimulus-induced insulin secretion in human subjects. (nih.gov)
  • Humulin, one brand name for a group of biosynthetic human insulin products, is synthesized in a laboratory strain of Escherichia coli bacteria which has been genetically altered with recombinant DNA to produce biosynthetic human insulin. (wikipedia.org)
  • In 2017, human insulin was the 73rd most commonly prescribed medication in the United States, with more than ten million prescriptions. (wikipedia.org)
  • Insulin from these sources is effective in humans as it is highly similar to human insulin (three amino acid difference in bovine insulin, one amino acid difference in porcine). (wikipedia.org)
  • Minor allergic reactions still occur occasionally, even to synthetic "human" insulin varieties. (wikipedia.org)
  • Beginning in 1982, biosynthetic "human" insulin has been manufactured for clinical use through genetic engineering techniques using recombinant DNA technology. (wikipedia.org)
  • Conventional insulins include regular human insulin and intermediate-acting neutral protamine Hagedorn insulin. (cmaj.ca)
  • Approximate pharmacokinetic profiles of human insulin and insulin analoguesHirsch IB. (slideserve.com)
  • 1 ml contains 100 IU insulin human (produced in E. coli by recombinant DNA technology). (medicines.org.uk)
  • Treatment with human insulin may cause formation of antibodies, but titres of antibodies are lower than those to purified animal insulin. (medicines.org.uk)
  • The consensus model of stimulus-secretion coupling in beta cells attributes glucose-induced insulin secretion to a sequence of events involving acceleration of metabolism, closure of ATP-sensitive K+ channels, depolarisation, influx of Ca2+ and a rise in cytosolic free Ca2+ concentration ([Ca2+]c). (semanticscholar.org)