A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
The behavior of performing an act persistently and repetitively without it leading to reward or pleasure. The act is usually a small, circumscribed behavior, almost ritualistic, yet not pathologically disturbing. Examples of compulsive behavior include twirling of hair, checking something constantly, not wanting pennies in change, straightening tilted pictures, etc.
An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.
Disorders related or resulting from use of cocaine.
Persistent, unwanted idea or impulse which is considered normal when it does not markedly interfere with mental processes or emotional adjustment.
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Organizations which are not operated for a profit and may be supported by endowments or private contributions.
Exclusive legal rights or privileges applied to inventions, plants, etc.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action.
An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.
A worm-like blind tube extension from the CECUM.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
A family of hexahydropyridines.
Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.
A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Effect of psychotropic drugs on caudate spindle in cats. (1/18)

To ascertain whether neuroleptics act on the caudate nucleus itself, the effects of these compounds as well as other centrally acting drugs were examined in relation to caudate spindle and EEG arousal responses (sciatic nerve stimulation) in gallamine-immobilized cats. Haloperidol and chlorpromazine enhanced the caudate spindle at a dose which had no effect on the EEG arousal response. On the other hand, clozapine and a higher dose of chlorpromazine enhanced the caudate spindle, but depressed the arousal response. High frequency stimulation of the sciatic nerve suppressed the caudate spindle. Pentobarbital, biperiden and diazepam, while depressing the arousal response, caused an enhancement of the caudate spindle. Imipramine at a low dose had no effect on either response, whereas at a high dose this drug enhanced the caudate spindle with concomitant depression of the arousal response. From these results, it may be concluded that the enhancing action on the caudate spindle induced by haloperidol and a low dose of chlorpromazine is due to an increase in susceptibility of the caudate nucleus itself. In addition, it is suggested that depression of the activating system is involved in an appearance of the caudate spindle.  (+info)

Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma. (2/18)

Estimation of xenobiotic kinetics in humans frequently relies upon extrapolation from experimental data generated in animals. In an accompanying paper, we have presented a unique, generic, physiologically based pharmacokinetic model and described its application to the prediction of rat plasma pharmacokinetics from in vitro data alone. Here we demonstrate the application of the same model, parameterized for human physiology, to the estimation of plasma pharmacokinetics in humans and report a comparative evaluation against some recently published predictive methods that involve scaling from in vivo animal data. The model was parameterized through an optimization process, using a training set of in vivo data taken from the literature, and validated using a separate test set of published in vivo data. On average, the vertical divergence of the predicted plasma concentrations from the observed data, on a semilog concentration-time plot, was 0.47 log unit. For the training set, more than 80% of the predicted values of a standardized measure of the area under the concentration-time curve were within 3-fold of the observed values; over 70% of the test set predictions were within the same margin. Furthermore, in terms of predicting human clearance for the test set, the model was found to match or exceed the performance of three published interspecies scaling methods, all of which showed a distinct bias toward overprediction. We conclude that the generic physiologically based pharmacokinetic model, as a means of integrating readily determined in vitro and/or in silico data, is potentially a powerful, cost-effective tool for predicting human xenobiotic kinetics in drug discovery and risk assessment.  (+info)

The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. (3/18)

The GABAergic drug baclofen and the cholinergic drug physostigmine were administered to patients with upbeat and downbeat nystagmus. Baclofen (orally, 5 mg three times daily) reduced nystagmus slow phase velocity and distressing oscillopsia by 25-75% in four out of five patients (two upbeat nystagmus; two downbeat nystagmus). Physostigmine (1 mg single intravenous injection) increased nystagmus in five additional patients with downbeat (1) or positional downbeat nystagmus (4) for a duration of 15-20 minutes. The different interactions of baclofen and physostigmine on neurotransmission subserving vertical vestibulo-ocular reflex could account for these effects. The response to baclofen appears to be a GABA-B-ergic effect with augmentation of the physiological inhibitory influence of the vestibulo-cerebellum on the vestibular nuclei. Similarly baclofen has an inhibitory effect on the velocity storage mechanism. Cholinergic action may cause the increment of nystagmus by physostigmine.  (+info)

The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study. (4/18)

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Ziprasidone vs olanzapine in recent-onset schizophrenia and schizoaffective disorder: results of an 8-week double-blind randomized controlled trial. (5/18)

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A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment. (6/18)

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Hemiparkinsonism-hemiatrophy syndrome. (7/18)

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Polypharmacy in the treatment of schizophrenic patients in three University Centers in the Federation of Bosnia and Herzegovina (F/BH). (8/18)

BACKGROUND: Polypharmacy in psychiatry is becoming the rule rather than the exception. Using more drugs at same time usually occurs where single drugs are considered insufficiently effective. SUBJECTS AND METHODS: The sample consisted of 216 patients: 85 from Sarajevo, and 44 and 87 respectively from Mostar and Tuzla. All schizophrenic patients who were hospitalised in three University Centers of F/BiH (Sarajevo, Tuzla, Mostar) on a particular day are included in the study. This included patients of both sexes (131 (60.65%) males and 85 females (39.35%)), 20-60 ages, who were on antipsychotic treatment with an established diagnosis of schizophrenia by the treating psychiatrist. The research was performed in the year 2004. The census of patients was conducted simultaneously in all three Centers, using a questionnaire in which all routine prescribed antipsychotics were registered, as the common method of the administration, and the doses as well saving as data for other medications that were simultaneously prescribed to the patients that day. RESULTS: Within the total sample the most frequently applied classical antipsychotics were haloperidol, promazine and from the group of new antipsychotics clozapine. The most frequently used other medications were biperidine and diazepam. The administration of all medication was followed through recording of individual doses, daily doses and frequency of administration. There are statistically significant differences regarding the frequency of biperidine use between the centers (p=0.008). CONCLUSION: In three University Clinical Centers of the Federation of Bosnia and Herzegovina (Sarajevo, Tuzla and Mostar), the applied rule is that more drugs in the treatment of schizophrenic psychosis and doing polypharmacy is the inevitable approach to treatment. The concept behind the polypharmacy is based on the fact that antipsychotic drugs do not cover all the symptoms of schizophrenic psychosis, and that additional medications may correct iatrogenic side effects caused by antipsychotic drugs. It is expected that the new atypical antipsychotics will treat much broader symptoms of psychosis and will not cause extrapyramidal side effects, as do the typical antipsychotics.  (+info)

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Browsing University Centres and Units by Title A 24-week, multicenter, open-label, randomized study to compare changes in glucose metabolism in patients with schizophrenia receiving treatment with olanzapine, quetiapine, or risperidone ...
Market Research Future adds new report of Global Nano therapy Market Research Report- Forecast To 2027 it contains Company information, geographical data and Table of Content. Nanotechnology offers the likelihood to improve tranquilize dissolvability and quality, drag out medicine half-lives in plasma, limit off target effects, and accumulate drugs at a goal site. Nanotechnology is described as submicron evaluated nuclear devices or nanoparticles pervasively running from 5 to 500 nm in one measurement. Liberal past investigation effort has realized procedures to combine supportive administrators into biocompatible Nano gadgets including polymer nanoparticles, liposomes, micelle structures, inorganic nanoparticles, nanotubes, and dendrites. The Global Nano Therapy Market is required to develop at great CAGR.. Get a Sample Report @ https://www.marketresearchfuture.com/sample_request/924 .. Competitive Analysis: Some of the key players for the Global Nano Therapy are: Washington University center ...
A trusted name in imaging services since 1995, University Center Imaging (UCI) provides the highest level of patient care and testing services available in a full service diagnostic imaging facility. Using state of the art equipment, UCI is able to reduce scan times and provide diagnostic procedures that arent offered in most outpatient imaging facilities. This gold standard in outpatient radiology performance has fostered a high level of confidence throughout the area for physicians and their patients.
University Centre Shrewsbury (UCS) staff, students and partners are kick-starting groundbreaking research and developing solutions to improve the health of people with heart, lung and circulation diseases.. Global company Renew Health is funding a project led by John Buckley, Professor of Applied Exercise Science at UCS and its Centre for Active Living. The investment is part of Renews Global Billions in Change movement which is tackling pressing problems around the world in the areas of water purification, accessible energy and preventative healthcare.. The initiative at UCS is investigating the benefits of External Counter Pulsation (ECP) Therapy, a treatment proven to improve peoples cardiovascular health. This includes people with heart disease who have not been able to have by-pass surgery or coronary angioplasty (stents) - a procedure used to widen blocked or narrowed arteries in the heart.. During Renew ECP treatment, inflatable cuffs (similar to blood pressure cuffs) are wrapped around ...
Cecil K. and Philip Drinker Professor of Environmental PhysiologyDirector, Center for Children and Environmental HealthHarvard University Center for the EnvironmentHarvard School of Public Health
Find info concerning University Center MI laboratory jobs. Seek out accredited healthcare programs for the best training. Given a brief hospital internship or prior work experience, you can expect a great return on your medical education.
Edward C. Jeffrey Professor of BiologyHarvard University Center for the EnvironmentDept. of Organismic and Evolutionary BiologyMicrobial Sciences Initiative
Project Title: Extended cell-free protein expression system for amino acid labeling and structural biology studies at Miami Universitys Center for Bioinformatics and Functional Genomics (CBFG).. Project Lead: Carole Dabney-Smith. Email: [email protected] Phone: (513) 529-8091. Affiliation: CAS. Other Team Members: Andor Kiss, Gary A. Lorigan. Project Details: This project is a request for a temperature regulated, heating and cooling capable, mixing, dry incubator with accessories capable of handling tube with different volumes and a starter expression kit. This will enable undergraduate and graduate student users to produce microgram to milligram quantities of in vitro expressed protein in a semi-high throughput fashion to aid in the investigation of protein structure/function relationships of any protein. One consistent barrier that impedes the progress of, discovery of structure/function relationships has been the ability to reliably and quickly generate protein, e.g., with single amino ...
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Cocaine consumption affects around 13.4 mi people or 0.3% of the world population between 15 and 64 years old. The drug dependence has been described by many authors as a dysfunction of the brain reward system. Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process. Then the present study aims to evaluate biperiden efficacy (a cholinergic antagonist) in attenuate compulsion, one o the main symptoms of the drug dependence. To accomplish this purpose 60 cocaine or crack male users between 18 and 50 years old will be study. This is a double-blind controlled and randomized placebo study. All the patients will be treated with brief intervention therapy (BIT), and half of them will receive biperiden (6mg/day) while the other half will receive placebo. The treatment efficacy will be evaluated through the comparison between the values obtained on the following measures before ...
Heather Congdon, PharmD, BCPS, CDE, associate professor in the Department of Pharmacy Practice and Science (PPS) at the University of Maryland School of Pharmacy and assistant dean for the School at the Universities at Shady Grove, has been named a co-director of the new Center for Interprofessional Education (IPE) at the University of Maryland, Baltimore (UMB). The Center, which officially launched on Nov. 20, is directed by Jane M. Kirschling, PhD, RN, FAAN, dean and professor of the School of Nursing, and monitors all of the IPE initiatives in which faculty, staff, and students at UMB are engaged.. The University of Maryland School of Pharmacy has long been a proponent of interprofessional education and practice, a concept that improves patient outcomes and allows each health care professional to practice at the top of their license, says Natalie D. Eddington, PhD, FAAPS, FCP, dean and professor dean of the School of Pharmacy. The naming of Dr. Congdon as a co-director of the Universitys ...
The Center for Biomedical Research promotes and supports biomedical research and education at Oakland University and allied institutions. It enhances collaborative efforts in biomedical research projects, recruits and retains outstanding biomedical researchers and supports their needs ...
Explore the underground laboratory of Dr. Peter Girguis and the Harvard University Department of Organismic and Evolutionary Biology during the HUBWeek Adventure, Undersea Research and the Future of Science. In his labyrinth of underwater discoveries, meet the creatures that sparked animators imagination for Finding Nemo. Shed some light on modern oceanographic research and how the deep sea and its denizens play a critical role in supporting all life on Earth. Hear how renewable energy is finally becoming competitive with fossil-fuel sources. Finally, find out how discoveries in natural ecosystems are being used to treat and cure disease.. Though the deep sea represents the vast majority of our biosphere, we have literally seen less of our ocean floor than weve seen of the surface of Mars. Nonetheless, the deep sea is a critical part of our ecosystem, and the Girguis lab at Harvard University is committed to understanding how animals and microbes make a living in the deep sea. Their lab ...
|p| Animal and Land Sciences research at Hartpury encompasses a range of research areas representing the interests and experience of our staff.|/p|
Were proud to be able to offer Dual Career Accreditation via the Talented Athlete Scholarship Scheme. This is a Sport England funded partnership between athletes, education institutions, and national governing bodies of sport.. The Scheme helps athletes in education - aged 16-plus - to get the very best from their sporting and academic careers without having to choose between the two.. Click here to find out more about TASS. ...
Click any of the links below to learn information about orientation at one of our off-campus centers. If you need information regarding orientation on our Ellensburg campus, click here.. ...
Description of Subjects: Fenway Health medical patients who have had at least 2 HIV primary care visits at Fenway in a 12 month period and are 18 years or older ...
Statistics and Data Analysis Using R is a hands-on introduction to the R statistical software suite for biomedical scientists. It is assumed that the student is familiar with the plots and statistical summaries that are most commonly used in biomedical papers, but no formal background in statistics or programming is necessary. The primary objective is learning to use R, but the course also emphasizes the standards of practice that programmers and data analysts have implemented to ensure transparency, accuracy and accountability. Students are required to have a laptop ...
Kočí, Kamila; Matějů, Kateřina; Obalová, Lucie; Krejčíková, Simona; Lacný, Zdenek; Plachá, Daniela; Čapek, Libor; Hospodková, Alice; Šolcová, Olga (Applied Catalysis. B, Environmental. 2010, vol. 96, issues 3-4, p. 239-244.) ...
On December of 2017, several members from the Association of University Centers on Disabilities (AUCD) network, along with other professionals from various backgrounds, convened to form the Inclusive Health Project Workgroup. The purpose of this workgroup was to assist in creating inclusion principles and guidelines for implementing health-related activities for people with intellectual disabilities (ID). These principles and guidelines would serve to support national-level organizations to adopt and promote inclusive approaches to health for people with ID, and provide useful information for organizations on how to foster inclusion of people with ID in national organizations. This exceptional workgroup, which encompassed of directors and specialists from University Centers for Excellence in Developmental Disabilities (UCEDD), used both their professional and individual experiences in the realm of disabilities/ID to develop the Foundational Principles for Sustainable Inclusion of People with
Many diseases are associated with incredible pain and suf- fering. Others impair func- tion and independence to the extent that human dignity is eroded. In many instances the natural history of such conditions often leads ...
Consumer involvement and input is a crucial component of any UCEDD program. The UCEDD must involve consumers, in the form of a committee, who represent ...
Young adults with autism face many new expectations and challenges - with none of the support that is available during high school. BY DEBORAH RUDACILL...
The flocculus of cerebellum inhibits the vestibular nuclei and keeps the eyes steady during downward gaze. Disinhibition of the flocculus leads to slow upward drift of the eyes, followed by corrective downward saccade-the downbeat-hence the name downbeat nystagmus. Asymmetry in the vertical smooth pursuit pathway or, imbalance in the neural tone of the central connections of the vertical semicircular canals and otoliths can cause downbeat nystagmus. Idiopathic downbeat nystagmus, however, is the most common form.. Historically, the therapeutic approach for downbeat nystagmus has focused on the compounds that affect serum pH or inhibitory neurotransmitters modulating the cell membrane function. Acetazolamide was traditionally used for the treatment of downbeat nystagmus in patients with episodic ataxia.1 Baclofen (reinforcing the function of inhibitory neurotransmitter gamma-amino butyric acid (GABA)) or gabapentin (blocking alpha-2-delta calcium channels) rarely improved downbeat nystagmus. ...
Since its founding in 2001, the Nebraska University Center for Information Assurance (NUCIA) has helped improve the posture of information assurance awareness locally, regionally and nationally. The collaborative efforts of faculty, students and community partners have earned UNO the distinction of being named a Center of Academic Excellence in Information Assurance Education by the National Security Agency (NSA).. Studying information assurance and cybersecurity is a little bit like studying medicine: theres an endless list of applications and possibilities. Other IS&T disciplines such as computer science and bioinformatics intertwine with cybersecurity coursework. Theres even an overlap with criminal justice.. Any company that conducts electronic commerce will need cybersecurity. Security threats are continually evolving, and they range from hacking a home-based personal computer to large-scale communication systems. NUCIA prepares students to become security professionals capable of ...
The Estonian Research Council has announced a competition for post-doctoral grants - for candidates interested in working at Estonian universities. Tallinn University Center of Excellence in Media Innovation and Digital Culture (MEDIT) invites interested emerging scholars to make contact with us and discuss research interests and submitting an application ...
PNA Innovations co-founders Bruce A. Armitage, Ph.D., and Danith H. Ly, Ph.D., are featured on the InnovationCast (I-Cast) produced by Carnegie Mellon Universitys Center for Technology Transfer and Enterprise Creation (CTTEC).. Armitage and Ly describe PNA Innovations gamma peptide nucleic acid (gPNA) technology, a molecular hybrid of peptides and nucleic acids with that binds with exceptionally high affinity to complementary DNA and RNA targets.. What is unique about gPNA, the platform this company is built on, is that as opposed to regular PNA that is commercially available and has been around for the last 20 years, its already pre-organized into a right-hand helix to mimic that of the bound DNA and RNA target, Ly said. So in addition to binding single-stranded DNA and RNA, it can also invade double- stranded DNA, and I think that is the unique feature of this particular platform ...
Photocontact allergy is uncommon and considered to be a delayed type IV hypersensitivity reaction, in which a photoactivated chemical acts as an antigen or hapten. Photopatch testing is used to investigate and diagnose photocontact allergy; sunscreen chemicals are the major group of clinically relevant photoallergens. Both sunscreen users with normal sun sensitivity and patients with existing photosensitive diseases may develop photocontact allergy, and this needs to be considered as a differential diagnosis in the presentation of a patient with a photoexposed site dermatitis or with a history of a reaction to a sunscreen ...
Two small studies reported suboptimal therapy adherence in Parkinsons disease. We conducted a larger multicenter European study to assess medicine-taking behavior. Parkinsons disease patients taking dopaminergic therapy were enrolled in 8 centers in 5 countries, and disease severity and demographics recorded. Antiparkinson drug adherence was measured for 4 weeks using electronic monitoring bottles which record the date and time of cap opening (Aardex®, Switzerland). One hundred twelve patients, mean age 65 years (standard deviation (SD) 10), with Parkinsons disease for 7.7 (SD 8.2) years completed the study. Total median adherence (doses taken/doses prescribed) was 97.7% (interquartile range [IQ] 90.6-100), days adherence (correct dose days) was 86.2% (IQ 61.1-96.2) and timing adherence (doses taken at correct time intervals) was 24.4% (IQ 5.3-56.5). Fourteen patients (12.5%) took less than 80% of prescribed doses, which was defined as suboptimal adherence. Patients with satisfactory ...
The seminar aims to give a brief introduction to the main ideas of action research. Discussing the experiences of participatory action research within the Estonian National Museum context, the talk will highlight some of the practicalities when conducting action research and share some of the personal pitfalls and failures. Action research involves participating in a problem-solving situation, while simultaneously conducting research. The researcher shares their experiences and supports the organisation going through change with reflexive process about it. While action research is most commonly used in educational, medical/ social work settings, it has its uses also in the media and communication research as it is also much used in organisational studies ...
The Ohio State University created the Center for Clinical and Translational Science (CCTS) to catalyze research teams and facilitate innovation through creation...
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ABDEEN, Z., BERMAN, T., AZMI, K., ABU SEIR, R., AGHA, H., EIN-MOR, E., GOEEN, T., STEIN, Y., RICHTER, E. & CALDERON-MARGALIT, R. 2016. Urinary organophosphate metabolite levels in Palestinian pregnant women: results of the Middle East Regional Cooperation Project. International Journal of Environmental Health Research, 26, 254-266. BERMAN, T., GOLDSMITH, R., LEVINE, H. & GROTTO, I. 2016. Human biomonitoring in Israel: Recent results and lessons learned. International Journal of Hygiene Environ Health, 16, 30107-9. BERMAN, T., LEVINE, H., GAMZU, R. & GROTTO, I. 2012. Trends in reproductive health in Israel: implications for environmental health policy. Israel Journal of Health Policy Research, 1. CHIU, Y.-H., GASKINS, A. J., WILLIAMS, P. L., MENDIOLA, J., JORGENSEN, N., LEVINE, H., HAUSER, R., SWAN, S. H. & CHAVARRO, J. E. 2016. Intake of fruits and vegetables with low-to-moderate pesticide residues is positively associated with semen-quality parameters among young healthy men. Journal of ...
Macek, B., et al. Global and Site-Specific Quantitative Phosphoproteomics: Principles and Applications, Annu. Rev. Pharmacol. Toxicol. 2009. 49: 199-221. doi: 10.1146/annurev.pharmtox.011008.145606 ...
Reed, D. P., J. J. Herod, and J. B. Sickel. 1997. A comparison of larval development in the zebra mussel, Dreissena polymorpha, (Bivalvia: Dreissenidae) up to the free-swimming trochophore stage in Tennessee and Ohio River water. Proceedings of the seventh symposium on the natural history of lower Tennessee and Cumberland River valleys, Austin Peay State University Center for Field Biology and Murray State University Center for Reservoir Research. 7:85-98. ...
Reed, D. , J. Herod, and J. Sickel. A comparison of larval development in the zebra mussel (Dreissena polymorpha) up to the free-swimming trochophore stage in Tennessee and Ohio River water. Proceedings of the Seventh Symposium on The Natural History of Lower Tennessee and Cumberland River Valleys. Sponsored by the Austin Peay State University Center for Field Biology and the Murray State University Center for Reservoir Research. 1997 ...
Presented by Jeffrey Hazey, MD at the SAGES 2014 Meeting; Panel - Endoscopic Management of Bariatric Complications operative strategies-2:34 initial clinical presentation-2:51 IOC-3:48 percutaneous or endoscopic strategies-4:55 antegrade/percutaneous approach after placement of PTC-6:14 background with c Keyword(s): 12 Fr sheath, 15 mm trocar, 30 Fr access, 30 Fr G-tube, 6 wk interval ERCP, access to […] ...
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Abstract: A pandemic influenza occurs when a new strain of influenza virus surfaces in the human population and spreads efficiently from person to person. The use of pharmaceutical interventions (prescription antiviral drugs and vaccine) plays an important role in a multi-faceted public health response to an infectious disease outbreak. We explore consequences of decisions on the amount of antiviral drug regimens to stockpile and the strategies for prophylaxis use of antivirals during an influenza pandemic. We also evaluate health benefits of different prophylactic antiviral use strategies in terms of disease attack rate and hospital surge arrivals considering uncertainties surrounding influenza spread and containment ...
The field of genetics is expanding at an ever increasing pace with hardly a week going by without news of the discovery of a specific gene for a disease, the development of a new technique to manipulate genes or a gene target for therapy.. There are many ethical considerations being thrown up by these fascinating developments, and for those who enter this field there will be some difficult decisions to make. The list seems endless, but one thing is for sure these are extremely stimulating times in which to be a geneticist.. In this latest blog from Dr Elizabeth OBrien (pictured), Programme Leader for Medical Genetics, find out what you should be considering before embarking on the course, as well as the kind of questions you should be asking yourself. Do you have a real interest and enthusiasm for the subject? There are many concepts that you will need to understand as you progress, and this interest will help you to gain the necessary knowledge to truly understand the subject and to follow ...
There is no AED or medication that has been demonstrated to affect the development of post-traumatic epilepsy. Biperiden is a cholinergic antagonist, acting in the muscarinic receptor, that is widely used as an anti Parkinson drug. The investigators data with animal models of epilepsy indicate that anti-muscarinic agents might affect the natural course of the disease in the case of post-traumatic epilepsy ...
This is the accessible text file for GAO report number GAO-11-750 entitled Financial Derivatives: Disparate Tax Treatment and Information Gaps Create Uncertainty and Potential Abuse which was released on October 20, 2011. This text file was formatted by the U.S. Government Accountability Office (GAO) to be accessible to users with visual impairments, as part of a longer term project to improve GAO products accessibility. Every attempt has been made to maintain the structural and data integrity of the original printed product. Accessibility features, such as text descriptions of tables, consecutively numbered footnotes placed at the end of the file, and the text of agency comment letters, are provided but may not exactly duplicate the presentation or format of the printed version. The portable document format (PDF) file is an exact electronic replica of the printed version. We welcome your feedback. Please E-mail your comments regarding the contents or accessibility features of this document ...
Wallabies coach Robbie Deans remained upbeat on Sunday despite having to make three changes to his squad ahead of the touring British and Irish Lions...
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Article: A True Picture of Black Skin by Teju Cole. You may have read about the recent relaunch of the New York Times Magazine, which includes some fairly dramatic changes in design, content, and, in particular, their online presence. There are quite a few things about this that sound exciting to me, including the fact that they will be printing poetry every week and are turning The Ethicist into a podcast. Probably the most exciting thing, though, is a section called The Ons, which will feature four different critics in rotation, each focusing on a different area or field; one of these will be Teju Cole, writing about photography. Ive really enjoyed both of Teju Coles novels, particularly Open City, as well as some of his other writing on photography; he is an incredibly intelligent and thoughtful writer, and if the level of discussion in the magazine in general is anywhere close to his standard, it will be fantastic. This first piece is about the photographer Roy DeCarava, of whom Id ...
Drug-drug interactions can be pharmacodynamic (combined pharmacologic effects) or pharmacokinetic (alteration of plasma levels). The risks of using haloperidol in combination with other drugs have been evaluated as described below.. Pharmacodynamic Interactions Since QT-prolongation has been observed during haloperidol treatment, caution is advised when prescribing to a patient with QT-prolongation conditions (long QT-syndrome, hypokalemia, electrolyte imbalance) or to patients receiving medications known to prolong the QT-interval or known to cause electrolyte imbalance.. If concomitant antiparkinson medication is required, it may have to be continued after haloperidol is discontinued because of the difference in excretion rates. If both are discontinued simultaneously, extrapyramidal symptoms may occur. The physician should keep in mind the possible increase in intraocular pressure when anticholinergic drugs, including antiparkinson agents, are administered concomitantly with ...
IRVINE - UC Irvine researchers have developed a technique that enables them to see a pathway in the human brain to the area that stores memories, one of the project scientists said today.. Craig Stark, the principal investigator and interim director of the universitys Center for the Neurobiology of Learning and Memory, said researchers used new techniques that offer higher-resolution images from an MRI machine, enabling them to find the long-hidden section in the brain.. The discovery of the so-called Perforant Path could help speed up diagnoses of Alzheimers disease, Stark said.. Weve long known this is one of the main connections between two portions of the brain responsible for episodic memory, Stark said. The problem has been that while we can look at it in a rat after dissecting the brain, or in non-human primates, but to actually see it in humans, and, more importantly, in perfectly healthy humans in a non-invasive way is something weve never been able to do until now.. The ...
Eventbrite - The Post Graduate Center presents The Heart of the Matter: Concepts and Techniques in the Treatment of Survivors of Childhood Sexual Abuse (CSA Certificate Workshop #3) - Friday, October 7, 2016 at University Center, Chester, PA. Find event and registration information.
In the first study to compare the results of cognitive training by body mass index (BMI) category, scientists from the Indiana University Center for Aging Research found that memory training provided only one-third the benefit ...
The technology was developed by Philip Low, the Ralph C. Corley Distinguished Professor of Chemistry at Purdue University, director of the Purdue University Center for Drug Discovery and co-founder of On Target Laboratories. The optical imaging technology is another important milestone in cancer treatment advancements being piloted by Phil Low and other promising researchers at Purdue, said Mitch Daniels, Purdue University president. It also is a prime example of how innovations being developed in Indiana can be advanced through partnerships with other world-class institutions like the Leiden University Medical Center in the Netherlands. On Target Laboratories lead molecule OTL38 achieved first-in-humans status at the Center for Human Drug Research, affiliated with Leiden University. It was the first time the compound was given to humans as part of testing. This clinical trial in healthy volunteers is complete and it demonstrated the safety of the molecule at various doses. The next step in ...
All MD students must complete an MD Project by the end of Stage 3 Year 3. The MD Project is intended to be a scholarly investigation into a topic relevant to health or medicine, leading to a formal report submitted for summative assessment. Students MD Project work is based in their allocated Clinical School, or in the Clinical School of the Childrens Hospital at Westmead, the School of Rural Health at Dubbo or Orange, the University Centre for Rural Health at Lismore, the University Department of Rural Health at Broken Hill, the School of Public Health, or in a project group within the Sydney Medical Program Education Office. Each student is allocated to an MD Project Group supervised by an academic staff member or affiliate. Typically an MD Project Group comprises about five students and a supervisor, who is known as a Research Tutor ...
The Internet History Sourcebooks Project is located at the History Department of Fordham University, New York. The Internet Medieval Sourcebook, and other medieval components of the project, are located at the Fordham University Center for Medieval Studies.The IHSP recognizes the contribution of Fordham University, the Fordham University History Department, and the Fordham Center for Medieval Studies in providing web space and server support for the project. The IHSP is a project independent of Fordham University. Although the IHSP seeks to follow all applicable copyright law, Fordham University is not the institutional owner, and is not liable as the result of any legal action. ...
Students and staff alike are invited to take part in the International Day where study opportunities and collaboration abroad will be introduced. Representatives from various embassies and other organisations will be present. Events at the University Centre: music, dance, lottery, international finger food and beverages and more.. ...
The USC University Center for Excellence in the Developmental Disabilities (UCEDD) at Childrens Hospital Los Angeles is offering an in-house training program for parents of children with special needs... Read more. ...
The Boston University Center for Computational Science (CCS) was founded in 1990 to coordinate and promote computationally based research, to foster computational science education and to provide for the expansion of computational resources and support.
The Boston University Center for Computational Science (CCS) was founded in 1990 to coordinate and promote computationally based research, to foster computational science education and to provide for the expansion of computational resources and support.
The Rutgers University Center of Ocean Observing Leadership (RU COOL) integrates across interdisciplinary scientific research, education and outreach using an operational ocean observing system. Faculty and students comprising the scientific teams participate in collaborative research programs in which academic, industry and government partnerships are forged between physicists and biologists, between scientists and engineers, and between observationalists and modelers. The education group is the focal point for outreach activities to the K-12 community and to non-science majors within Rutgers and schools/universities around the world. The Operations Center maintains a sustained coastal ocean observatory that provides real-time ocean data to the research and education groups and also serves as the training ground for Operational Oceanography students.
Researchers dont know exactly why, but sleepy people seem to have slower and less precise motor skills, Clete Kushida, M.D., Ph.D., director of Stanford University Center for Human Sleep Research told Prevention. Reflexes are dulled, balance and depth perception can be a little wonky and since you may also have trouble focusing, reaction time can be slowed, meaning you cant quite catch the egg carton before it hits the floor ...
As you walked through the University Centre this past week, you might have noticed posters all over the walls beckoning students to parties at clubs and bars all over the city. Or the tables boasting Smirnoff swag, or information about the club Kavali. And later in the evening, theres a good chance you noticed the elated yelling from students taking to the streets to head out to a party or two.. None of this in and of itself is unusual. After all, the Canadian Centre on Substance Abuses (CCSA) Cross-Canada Report on Student Alcohol and Drug Use shows that there is a consistency of alcohol and drug use across provinces, as well as gender. It seems that the prominent drinking culture at the University of Ottawa, and post-secondary schools across the country, is pervasive and here to stay.. On the other hand, as you transitioned to post-secondary school, you likely heard statements like dont drink from just about every authority figure in your home and campus life.. And although these two ...
Gallaudet Universitys Center for Continuing Studies, located in Washington, DC, offers continuing education courses, enrichment programs, and online courses.
Director of the Rensselaer Polytechnic Institute Center for Biotechnology & Interdisciplinary Studies (CBIS), conducting breakthrough research on bones, Deepak Vashishth, PhD, is working to redefine the role of a top tier research university: one that is engaged in public and private partnerships, involved in interdisciplinary research, and providing quality education, all to drive entrepreneurial, sustainable, socially responsible scientific discovery and technological innovation. Administrative leadership: Through his work as a University Center Director, previously as a School of Engineering Department head, and in professional societies he has successfully developed partnerships, Programs, and platforms, to drive translational scientific research across disciplines, sectors,and geographic boundaries. As Director of CBIS he oversees 70 resident and non-resident faculty (from each of the five Rensselaer Polytechnic Institute schools); engages with global partners in the public, private, and ...
Migratory animals are often blamed for the global spread of diseases, but new Deakin University research has shown their role may be less significant than previously thought.. With the rate of zoonotic diseases - pathogens that jump from animal hosts to humans - on the rise, migratory animals have been under increasing scrutiny and suspicion of aiding the spread of bird flu, Lyme disease, and even Ebola.. However, despite the fact that billions of animals fly, swim and walk around the globe every year on their seasonal migrations, researchers from Deakin Universitys Centre for Integrative Ecology (CIE) say there is surprisingly little direct evidence that migratory animals are frequently spreading pathogens long distances.. In humans, travelling increases our risk of getting ill because we come into contact with many new microbes that our immune system has never encountered before, said researcher and PhD candidate Alice Risely.. We wanted to work out if migrant animals are also more ...
William H. Neumeier1, Christine Grosso2, James H. Rimmer1 1 University of Alabama at Birmingham and Lakeshore Foundation Research Collaborative 2 Association of University Centers on Disabilities Obesity is an increasingly common condition that is characterized by an increase in the number and size of fat cells in the body. Obesity is most commonly measured by…
Ever wonder what current University of Memphis students think? Now you can find out! Jasons Favorite Place on the University of Memphis campus is the Involvement Zone in the University Center. The Involvement Zone is where students can find their place on campus by exploring more than 230 student organizations. You can get involved with academic, social, religious, and service based organizations, and can form your own organization with a group of friends. To visit campus in hopes of findin ...
George P. Smith II, a visiting fellow at Indiana Universitys Center for Law, Ethics, and Applied Research in Health Information, will deliver the centers first public lecture in tribute to his late friend, former IU President Myles N. Brand. The lecture is titled Managing End-of-Life Care: Medico-Legal, Social, Ethical, and Philosophical Challenges, and will be presented on Nov. 9 at 4 p.m. The public is invited to attend, inside the Maurer School of Laws Moot Court Room.
The Purdue University Center for Cancer Research Mass Spectrometry Shared Resource is part of the Purdue University Campus-wide Mass Spectrometry Center (CWMSC)...
... biperiden; and methenamine. The following are texts and other sources covering the title subject. Well-regarded intermediate ...
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BIPERIDEN HYDROCHLORIDE 63. BIPHENYL ACETIC ACID 64. BITOSCANATE 65. BLEOMYCIN 66. PRIMONIDINE TARTRATE ...
Biperiden Procyclidine Psychotropic Drugs and Related Compounds, 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, page ...
Hohagen, F; Lis, S; Riemann, D; Krieger, S; Meyer, C; Montero, R. F.; Grunze, H; Berger, M (1994). "Influence of biperiden and ... "Neuere pharmakologische Aspekte zu den zentralen Anticholinergika Biperiden und". Das Parkinson-Syndrom (in German). pp. 277-87 ...
Similar anticholinergic drugs such as biperiden and scopolamine have also produced delirium-like effects. These models, along ...
Biperiden • Bornaprin • CAR-226,086 • CAR-301,060 • CAR-302,196 • CAR-302,282 • CAR-302,368 • CAR-302,537 • CAR-302,668 • CS- ...
The resulting norbornene derivative is an intermediate in the synthesis of the anticholinergic drug biperiden. Via its ...
biperiden (en) , (S)-(−)-carbidopa monohydrate (en) , pergolide (en) , (±)-deprenyl (en) , tolcapone (en) , bromokriptina, ...
The molecular formula C21H29NO (molar mass: 311.46 g/mol) may refer to: Alphamethadol Betamethadol Biperiden Dimepheptanol ...
Examples of common anticholinergics: Antimuscarinic agents Atropine Benztropine (Cogentin) Biperiden Chlorpheniramine (Chlor- ...
Some synthetic anticholinergics, such as biperiden, may counteract the central symptoms of nerve agent poisoning better than ...
Other dyskinesias Huntington's chorea Spasmodic torticollis Dystonia Biperiden (bicyclic ring) Cycrimine (cyclopentanyl instead ...
... biperiden MeSH D03.383.621.135 --- cisapride MeSH D03.383.621.147 --- clopamide MeSH D03.383.621.160 --- cyproheptadine MeSH ...
... biperiden (INN) biphasic insulin injection (INN) Biphetamine Biphetap biricodar (INN) biriperone (INN) Bisac-Evac bisacodyl ( ...
Alverine Amiodarone Amitriptyline Amlodipine Aprindine Astemizole AY-9944 Benzatropine Bepridil Biperiden Camylofin Carvedilol ...
... α Anastrozoleα Bicalutamideα Dexamethasoneα Hydrocortisoneα Leuprorelinα Methylprednisoloneα Prednisoloneα Tamoxifenα Biperiden ...
... biperiden MeSH D02.455.426.392 --- hydrocarbons, alicyclic MeSH D02.455.426.392.368 --- cycloparaffins MeSH D02.455.426.392. ...
N04AA01 Trihexyphenidyl N04AA02 Biperiden N04AA03 Metixene N04AA04 Procyclidine N04AA05 Profenamine N04AA08 Dexetimide N04AA09 ...
Pharmacological treatments have included an anticholinergic (biperiden), antiepileptics (carbamazepine, valproate), an ...
... is in the anticholinergic family of medication. Biperiden was approved for medical use in the United States in 1959. ... Additionally, biperiden may decrease maternal milk production. It is therefore recommended that biperiden is not used during ... Biperiden does also act as FIASMA (functional inhibitor of acid sphingomyelinase). Biperiden was synthesized by the German ... Biperiden may be abused due to a short acting mood-elevating and euphoriant effect. The normal sleep architecture may be ...
... (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.[2][3][1] While its exact mechanism of action is not well characterized,[2] it is believed to be an NMDA receptor antagonist,[4][5] but also promoting the synthesis of dopamine.[6] Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.[6][7] ...
InChI=1S/C26H37NO3/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3/t23-/m1/s1 ...
The topic of this article may not meet Wikipedia's general notability guideline. Please help to establish notability by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be established, the article is likely to be merged, redirected, or deleted ...
... (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine.[1] A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1] In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist.[2] It produces antidepressant-like effects in rats.[2] However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus.[2] This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.[2] ...
There are a variety of clinically useful ergoline derivatives for the purpose of vasoconstriction, the treatment of migraines, and treatment of Parkinson's disease. Ergoline alkaloids found their place in pharmacology long before modern medicine as preparations of ergot were often used by midwives in the 12th century to stimulate childbirth.[10] Following Arthur Stoll's isolation of ergometrine, the therapeutic use of ergoline derivatives became well explored. The induction of uterine contractions via the preparation of ergot was attributed to ergonovine, an ergoline derivative found in ergot, which is a powerful oxytocic. From this, methergine, a synthetic derivative, was elucidated.[7] While used to facilitate child birth, ergoline derivatives can pass into breast milk and should not be used during breastfeeding.[11] They are uterine contractors that can increase the risk of miscarriage during pregnancy.[3] Another example of medically relevant ergoline alkaloids is ergotamine, an alkaloid ...
Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.[2] With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition. ...
Four motor symptoms are considered cardinal in PD: tremor, slowness of movement (bradykinesia), rigidity, and postural instability.[29] The most common presenting sign is a coarse slow tremor of the hand at rest which disappears during voluntary movement of the affected arm and in the deeper stages of sleep.[29] It typically appears in only one hand, eventually affecting both hands as the disease progresses.[29] Frequency of PD tremor is between 4 and 6 hertz (cycles per second). A feature of tremor is pill-rolling, the tendency of the index finger and thumb to touch and perform together a circular movement.[29][30] The term derives from the similarity between the movement of people with PD and the early pharmaceutical technique of manually making pills.[30] Bradykinesia (slowness of movement) is found in every case of PD, and is due to disturbances in motor planning of movement initiation, and associated with difficulties along the whole course of the movement process, from planning to ...
... poisoning is characterized by miosis, blurred vision, increased salivation, excessive sweating, lacrimation, bronchial secretions, bronchoconstriction, bradycardia, abdominal cramping, increased gastric acid secretion, diarrhea and polyuria. If muscarine reaches the brain it can cause tremor, convulsions and hypothermia. Cardiac ventricles contain muscarinic receptors that mediate a decrease in the force of contractions leading to a lower blood pressure. If muscarine is administered intravenously, muscarine can trigger acute circulatory failure with cardiac arrest.[1] The symptoms of intoxication with mushrooms rich in muscarine, especially Inocybe, are very typical: The symptoms start early, after one-quarter to two hours, with headache, nausea, vomiting, and constriction of the pharynx. Then salivation, lacrimation, and diffuse perspiration set in, combined with miosis, disturbed accommodation, and reduced vision. Gastric and small bowel colic leads to diarrhea, and there is a ...
Experimental: Biperiden Thirty volunteers will take three pills of Biperiden (6mg/day) during two months. ... Drug: Biperiden Thirty volunteers will take three pills of Biperiden (6mg/day) during two months. ... Biperiden. Biperiden lactate. Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Physiological Effects of ... Cocaine/Crack and Reduction of Compulsion With Biperiden. The safety and scientific validity of this study is the ...
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Biperiden is in the anticholinergic family of medication. Biperiden was approved for medical use in the United States in 1959. ... Additionally, biperiden may decrease maternal milk production. It is therefore recommended that biperiden is not used during ... Biperiden does also act as FIASMA (functional inhibitor of acid sphingomyelinase). Biperiden was synthesized by the German ... Biperiden may be abused due to a short acting mood-elevating and euphoriant effect. The normal sleep architecture may be ...
Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the ... Biperiden is α-5-Norbornen-2-yl-α-phenyl-1-piperidinepropanol. It is a white, crystalline, odorless powder, slightly soluble in ... AKINETON (biperiden hydrochloride) Tablets, 2 mg each, white, embossed on one face with a triangle, bisected on the reverse and ... The LD50 of biperiden in the white mouse is 545 mg/kg orally, 195 mg/kg subcutaneously, and 56 mg/kg intravenously. The acute ...
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
Biperiden was discontinued and diazepam increased to 10 mg every 8 hours as needed for three weeks. Pregabalin was continued. ... Biperiden and other anticholinergic agents are potential drugs of abuse. This can be explained by their ability to ameliorate ... Eight days after the first visit the patient came back to the unit and admitted to continue using 6-8 mg of biperiden daily. He ... When biperiden was discontinued he experienced withdrawal symptoms (criteria 2) and continued to use it until the second visit ...
Experimental: Biperiden Thirty volunteers will take three pills of Biperiden (6mg/day) during two months. ... Drug: Biperiden Thirty volunteers will take three pills of Biperiden (6mg/day) during two months. ... Biperiden. Biperiden lactate. Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Physiological Effects of ... All the patients will be treated with brief intervention therapy (BIT), and half of them will receive biperiden (6mg/day) while ...
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Buy Biperiden hydrochloride (CAS 1235-82-1), a muscarinic receptor antagonist, from Santa Cruz. Purity: ≥97%, MF: C21H29NO•HCl ... Biperiden hydrochloride is a muscarinic receptor (mAChR M) antagonist that displays some selectivity for the mAChR M1 subtype ( ... Biperiden hydrochloride (CAS 1235-82-1) *bvseo_sdk, java_sdk, bvseo-3.2.0 ... Sudo et al (1999) Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 64 PL99. Brocks (1999) ...
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This eMedTV page further discusses what biperiden is used for, including possible off-label uses and whether it is safe for use ... This eMedTV page further discusses what biperiden is used for, including possible off-label uses and whether it is safe for use ... Treating Parkinsons disease and movement disorders caused by other drugs are among approved biperiden uses. ... Treating Parkinsons disease and movement disorders caused by other drugs are among approved biperiden uses. ...
Find information on Biperiden (Akineton) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... biperiden is a topic covered in the Daviss Drug Guide. To view the entire topic, please sign in or purchase a subscription. ... "Biperiden." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Medicine Central, im.unboundmedicine.com/medicine/view/ ... Davis-Drug-Guide/51099/all/biperiden. Quiring C, Sanoski CA, Vallerand AH. Biperiden. Daviss Drug Guide. F.A. Davis Company; ...
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Biperiden (Oral Route) Description and Brand Names - Mayo Clinic. ., chlorpromazine [Thorazine®], perphenazine [Trilafon®], ... Amifampridine Amitriptyline Amoxapine Atropine Belladonna Benztropine Biperiden Brompheniramine Carbinoxamine Carisoprodol ...
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Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs. So pathways could be considered as targets of small molecules. A link map between small molecules and pathways was constructed using gene expression profile, pathways, and gene expression of cancer cell line intervened by small molecules and then we analysed the topological characteristics of the link map. Three link patterns were identified based on different drug discovery implications for breast, liver, and lung cancer. Furthermore, molecules that significantly targeted the same pathways tended to treat the same diseases. These results can provide a valuable reference for identifying drug candidates and targets in molecularly targeted therapy.
Background Tardive dyskinesias (TDs) are involuntary movements of the tongue, lips, face, trunk, and extremities that occur in patients treated with long-term dopaminergic antagonist medications. Although they are associated with the use of neuroleptics, TDs apparently existed before the development of these agents.
  • Then the present study aims to evaluate biperiden efficacy (a cholinergic antagonist) in attenuate compulsion, one o the main symptoms of the drug dependence. (clinicaltrials.gov)
  • Biperiden, sold under the brandname Akineton among others, is a medication used to treat Parkinson disease and certain drug-induced movement disorders. (wikipedia.org)
  • Each AKINETON tablet for oral administration contains 2 mg biperiden hydrochloride. (nih.gov)
  • Biperiden hydrochloride is a muscarinic receptor (mAChR M) antagonist that displays some selectivity for the mAChR M1 subtype (K i values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for mAChR M1, mAChR M4, mAChR M3, mAChR M2 and mAChR M5 receptors, respectively). (scbt.com)
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  • Amifampridine Amitriptyline Amoxapine Atropine Belladonna Benztropine Biperiden Brompheniramine Carbinoxamine Carisoprodol Chlorpheniramine Chlorpromazine Clemastine Clidinium Clomipramine Clozapine Cyclobenzaprine Cyclopentolate Cyp. (mayoclinic.org)
  • Trihexyphenidyl derivatives may decrease the serum digitoxin concentration camps of biperiden. (top-web.us)
  • Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the sacrospinalis muscles and intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved abdominal skin. (nih.gov)
  • Other anticholinergic drugs (e.g. spasmolytics, antihistamines, TCAs) : Side effects of biperiden may be increased. (wikipedia.org)
  • In its role as a synthetic acetylcholine antagonist, biperiden has been analyzed as an alternative anticonvulsant for usage in the treatment of intoxication by organophosphorus nerve agents, such as sarin. (wikipedia.org)
  • Biperiden mimics an atropine intoxication with mydriasis, dryness of mucous membranes, red face, atonic states of bowels and bladder, and hyperthermia in high doses. (wikipedia.org)
  • Then the present study aims to evaluate biperiden efficacy (a cholinergic antagonist) in attenuate compulsion, one o the main symptoms of the drug dependence. (clinicaltrials.gov)
  • Hypersensitivity to biperiden Narrow angle glaucoma Ileus Caution : People with obstructive diseases of the urogenital tract, people with a known history of seizures and those with potentially dangerous tachycardia Dose-dependent side effects are frequent. (wikipedia.org)
  • These experimental doses were usually administered in conjunction with an anticholinergic, antiparkinsonian drug such as Biperiden or Benzatropine. (news-medical.net)
  • Queste dosi sperimentali sono state amministrate solitamente insieme con una droga quale Biperiden o una benzatropina anticolinergica e antiparkinsonian. (news-medical.net)
  • Biperiden belongs to a group of medicines known as anticholinergics. (emedtv.com)
  • Antipsychotics : Long-term use of biperiden may mask or increase the risk of tardive dyskinesia. (wikipedia.org)
  • Biperiden is used for the adjunctive treatment of all forms of Parkinson's disease and for reduced sweating in methadone users (postencephalitic, idiopathic, and arteriosclerotic). (wikipedia.org)
  • Some instances of dementia have been noted to correlate with chronic administration of anticholinergic medications such as Biperiden for Parkinson's disease. (wikipedia.org)
  • Biperiden is used for treating several conditions, such as Parkinson's disease and certain movement disorders caused by antipsychotic medications. (emedtv.com)
  • DDC 2 Metronidazole Salbutamol, sulfate Atenolol Biperiden Cyclophosphamide Co-Trimoxazole Dinitrate of isosorbide Indometacin Pyrimethamine Procarbazine Amitriptyline Amoxicillin Ciprofloxacin Flucytosine Fludrocortisone Haloperidol Hydrochlorothiazide Levonorgestrel 2! (tripod.com)
  • After stopping treatment with haloperidol, risperidone, and biperiden, which were ineffective and burdened the patient with severe akathisia, clozapine therapy was started. (redorbit.com)
  • So wil, let us know if the biperiden keeps working for you, i've heard that sometimes one can grow tolerant as far as the side effects go, of which the decreased sweating is one, at least as far as the anti-cholinergenic drugs go and boniva . (tripod.com)
  • Future in pharmacy and prevention of biperiden evaluation ii and bleomycin . (tripod.com)
  • Sudo et al (1999) Muscarinic receptor occupancy by biperiden in living human brain. (scbt.com)
  • abbott laboratories ltd., llc can supply biperiden all over the australia. (madcapcupcake.com)
  • Although participants were randomized to receive either 1,10 - phenanthroline or biperiden irrespective of their demographics, concomitant medications, or disease the history, expectation bias it may have been also present. (dreamakergifts.com)
  • 03). This category of medications includes anticonvulsants (primidone, biperiden, phenobarbital) and methadone. (womensmentalhealth.org)
  • Biperiden dependence: case report and literature review. (biomedsearch.com)
  • We are reporting the case of a patient who presented with hypoactive delirium as a consequence of biperiden dependence. (biomedsearch.com)
  • We are reporting a case of a patient who came to the addiction unit for treatment of biperiden dependence. (biomedsearch.com)
  • Additionally, biperiden may decrease maternal milk production. (wikipedia.org)
  • Biperiden is in the anticholinergic family of medication. (wikipedia.org)
  • Medicines web site http://www.who.int/medicines/areas/quality_assurance/en/index.html. (who.int)
  • All the patients will be treated with brief intervention therapy (BIT), and half of them will receive biperiden (6mg/day) while the other half will receive placebo. (clinicaltrials.gov)
  • Patients were formerly enrolled consecutively and were randomized relative to two basic treatment arms of equal numbers increased of patients, one involving therapy either with an IV combination of biperiden and mycophenolate mofetil and the other equipment involving therapy with IV diltiazem only. (top-web.us)
  • In this article, we showed 4 patients with schizophrenia who were treated at the Regional Hospital of High Specialty in Mental Health (Hospital Regional de Alta Especialidad en Salud Mental, HRAESM, in Spanish). (omicsonline.org)
  • Biperiden is also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy, such as akathisia. (wikipedia.org)
  • I saw think biperiden or dilute atracurium besylate could be initially helpful. (madcapcupcake.com)
  • In normal volunteers a single 10 mg intravenous dose of biperiden seemed to cause a transient rise in plasma cortisol and prolactin. (nih.gov)
  • Thirty volunteers will take three pills of Biperiden (6mg/day) during two months. (clinicaltrials.gov)
  • Patient reported self-medicating with biperiden and developing tolerance to this drug. (biomedsearch.com)
  • Given his multiple unsuccessful attempts to quit biperiden, the patient thought that he was addicted to this drug and wanted to be treated for it. (biomedsearch.com)
  • biperiden is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
  • Medicine Central , im.unboundmedicine.com/medicine/view/Davis-Drug-Guide/51099/all/biperiden. (unboundmedicine.com)
  • In this demographic study, the combination of biperiden with epinastine caused them significant reductions in mean that blood pressure and in output mean heart disease rate. (madcapcupcake.com)
  • Pregnancy : In animal studies biperiden had no embryo- or fetotoxic effects. (wikipedia.org)
  • Only limited pharmacokinetic studies of biperiden in humans are available. (nih.gov)
  • Biperiden can be effective for controlling most extrapyramidal symptoms. (emedtv.com)