A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
A specific protein in egg albumin that interacts with BIOTIN to render it unavailable to mammals, thereby producing biotin deficiency.
Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.
A 60-kDa extracellular protein of Streptomyces avidinii with four high-affinity biotin binding sites. Unlike AVIDIN, streptavidin has a near neutral isoelectric point and is free of carbohydrate side chains.
A carboxy-lyase that catalyzes the decarboxylation of (S)-2-Methyl-3-oxopropanoyl-CoA to propanoyl-CoA. In microorganisms the reaction can be coupled to the vectorial transport of SODIUM ions across the cytoplasmic membrane.
A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.
Enzymes which transfer sulfur atoms to various acceptor molecules. EC 2.8.1.
An enzyme which catalyzes the release of BIOTIN from biocytin. In human, defects in the enzyme are the cause of the organic acidemia MULTIPLE CARBOXYLASE DEFICIENCY or BIOTINIDASE DEFICIENCY.
Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.
A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.
The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.
A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.
A group of compounds that are derivatives of heptanedioic acid with the general formula R-C7H11O4.
Highly keratinized processes that are sharp and curved, or flat with pointed margins. They are found especially at the end of the limbs in certain animals.
A deficiency in the activities of biotin-dependent enzymes (propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, and PYRUVATE CARBOXYLASE) due to one of two defects in BIOTIN metabolism. The neonatal form is due to HOLOCARBOXYLASE SYNTHETASE DEFICIENCY. The late-onset form is due to BIOTINIDASE DEFICIENCY.
The white of an egg, especially a chicken's egg, used in cooking. It contains albumin. (Random House Unabridged Dictionary, 2d ed)
The late onset form of MULTIPLE CARBOXYLASE DEFICIENCY (deficiency of the activities of biotin-dependent enzymes propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, and PYRUVATE CARBOXYLASE) due to a defect or deficiency in biotinidase which is essential for recycling BIOTIN.
A condition due to deficiency in any member of the VITAMIN B COMPLEX. These B vitamins are water-soluble and must be obtained from the diet because they are easily lost in the urine. Unlike the lipid-soluble vitamins, they cannot be stored in the body fat.
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
The neonatal form of MULTIPLE CARBOXYLASE DEFICIENCY that is caused by a defect or deficiency in holocarboxylase synthetase. HLCS is the enzyme that covalently links biotin to the biotin dependent carboxylases (propionyl-CoA-carboxylase, pyruvate carboxylase, and beta-methylcrotonyl-CoA carboxylase).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.
Hair grooming, cleansing and modifying products meant for topical application to hair, usually human. They include sprays, bleaches, dyes, conditioners, rinses, shampoos, nutrient lotions, etc.
Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Recording of visual and sometimes sound signals on magnetic tape.
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Use of written, printed, or graphic materials upon or accompanying a food or its container or wrapper. The concept includes ingredients, NUTRITIONAL VALUE, directions, warnings, and other relevant information.
Form in which product is processed or wrapped and labeled. PRODUCT LABELING is also available.
Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
Set of instructions about how to prepare food for eating using specific instructions.
Regular course of eating and drinking adopted by a person or animal.
A group of disorders characterized by physiological and psychological disturbances in appetite or food intake.
Decrease in existing BODY WEIGHT.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.

Identification of three distinct receptor binding sites of murine interleukin-11. (1/2828)

Interleukin-11 (IL-11) is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor gp130. A complex of IL-11 and the IL-11 receptor (IL-11R) has been shown to interact with gp130, with high affinity, and to induce gp130- dependent signaling. In this study, we have identified residues crucial for the binding of murine IL-11 (mIL-11) to both the IL-11R and gp130 by examining the activities of mIL-11 mutants in receptor binding and cell proliferation assays. The location of these residues, as predicted from structural studies and a model of IL-11, reveals that mIL-11 has three distinct receptor binding sites. These are structurally and functionally analogous to the previously defined receptor binding sites I, II, and III of interleukin-6 (IL-6). This supports the hypothesis that IL-11 signals via the formation of a hexameric receptor complex and indicates that site III is a generic feature of cytokines that signal via association with gp130.  (+info)

Adhesion energy of receptor-mediated interaction measured by elastic deformation. (2/2828)

We investigated the role of receptor binding affinity in surface adhesion. A sensitive technique was developed to measure the surface energy of receptor-mediated adhesion. The experimental system involved a functionalized elastic agarose bead resting on a functionalized glass coverslip. Attractive intersurface forces pulled the two surfaces together, deforming the bead to produce an enlarged contact area. The Johnson-Kendall-Roberts (JKR) model was used to relate the surface energy of the interaction to the elasticity of the bead and the area of contact. The surface energies for different combinations of modified surfaces in solution were obtained from reflection interference contrast microscopy (RICM) measurements of the contact area formed by the bead and the coverslip. Studies with surfaces functionalized with ligand-receptor pairs showed that the relationship between surface energy and the association constant of the ligand binding has two regimes. At low binding affinity, surface energy increased linearly with the association constant, while surface energy increased logarithmically with the association constant in the high affinity regime.  (+info)

Molecular biology of biotin attachment to proteins. (3/2828)

Enzymatic attachment of biotin to proteins requires the interaction of a distinct domain of the acceptor protein (the "biotin domain") with the enzyme, biotin protein ligase, that catalyzes this essential and rare post-translational modification. Both biotin domains and biotin protein ligases are very strongly conserved throughout biology. This review concerns the protein structures and mechanisms involved in the covalent attachment of biotin to proteins.  (+info)

Human biotinidase isn't just for recycling biotin. (4/2828)

For years, the major role of biotin has been as the coenzyme for four carboxylases in humans. Although there has been evidence that biotin might have other functions, none has been firmly established. The discovery that human serum biotinidase has biotinyl-transferase activity, in addition to biotinidase hydrolase activity, presents new possibilities for the role of biotinidase in biotin metabolism. Specific transfer of biotin to histones by biotinidase provides a possible explanation for why biotin is found in the nucleus and the nature of its role in the regulation of protein transcription. Future studies will help to determine the functions of biotinidase in biotin metabolism and in disease states.  (+info)

Cellular uptake of biotin: mechanisms and regulation. (5/2828)

This review describes our knowledge of biotin transport in the small intestine of humans and other mammals and presents recent findings in the area. Previous studies have shown that biotin transport across the brush border membrane of the small intestinal absorptive cells occurs via a carrier-mediated, Na+ gradient-dependent, electroneutral mechanism. Exit of biotin out of the enterocyte, i.e., transport across the basolateral membrane, also occurs via a carrier-mediated process, but the process is Na+ independent and electrogenic. Recent studies from our laboratory have shown that the uptake process of biotin in Caco-2 cells, a human-derived cultured intestinal epithelial cell line, are under the cellular regulation of both a protein kinase C- and a Ca/calmodulin-mediated pathway. In addition, the uptake process is shared by another water-soluble vitamin, pantothenic acid. For the first time, other recent studies have detected the existence of a Na+-dependent, carrier-mediated mechanism for biotin uptake at the apical membrane of colonocytes, which could theoretically mediate absorption of the biotin synthesized by colonic microflora. This system was again found to be shared by pantothenic acid, which is also synthesized by the normal microflora of the large intestine.  (+info)

Advanced analysis of biotin metabolites in body fluids allows a more accurate measurement of biotin bioavailability and metabolism in humans. (6/2828)

In previous studies, the bioavailability of biotin in humans was estimated from the recovery of biotin in urine; urinary biotin was measured by microbial growth assays or assays of avidin-binding activity. These assays underestimate concentrations of biotin metabolites, which originate from beta-oxidation, sulfur oxidation or a combination. We have developed an HPLC/avidin-binding assay that is specific for biotin and its metabolites. With the use of the HPLC/avidin-binding assay, TLC and derivatization with p-dimethylaminocinnamaldehyde, we have identified and quantitated biotin and metabolites in urine from six healthy adults. Of that total, biotin accounted for 32+/-12%, bisnorbiotin for 52+/-15%, bisnorbiotin methyl ketone for 7.9+/-5.8%, biotin-d,l-sulfoxide for 4.0+/-3.2% and biotin sulfone for 3.6+/-1.9%. After intravenous administration of 18.4 micromol of biotin, the urinary excretion of biotin metabolites increased 21-130 times above baseline values. Because the biliary excretion of biotin is quantitatively minor (1.9+/-0.2% of an intravenous [14C]biotin dose in rats), intravenously administered biotin is not exposed to intestinal microorganisms. Thus we conclude that biotin metabolites in human urine originate from biotin catabolism in human tissues rather than biotin catabolism by intestinal microorganisms. With the use of the HPLC/avidin-binding assay, we estimated the bioavailability of biotin in adults from the urinary excretion of biotin and metabolites after ingestion of 2.1, 8.2 and 81.9 micromol of biotin. These data provide evidence that biotin is nearly completely absorbed.  (+info)

Biotin status: which are valid indicators and how do we know? (7/2828)

Although estimated average requirements for biotin have been proposed, the human requirements for biotin in specific populations and at various ages remain uncertain, in part because indicators of biotin status have not been validated. With the use of improved methods for measuring biotin and metabolites, a recent study indicated that decreased urinary excretion of biotin and bisnorbiotin is an early and sensitive indicator of biotin deficiency, but decreased serum concentration of biotin is not. Increased urinary excretion of 3-hydroxyisovaleric acid (3-HIA), a leucine metabolite that is excreted in increased quantities with deficiency of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, is also an early and sensitive indicator of biotin deficiency. When these indicators were assessed longitudinally in 13 pregnant women, biotin excretion was not significantly decreased early in pregnancy but did decrease significantly from early to late pregnancy. Excretion of 3-HIA was abnormally increased in about three-fourths of the women studied in both early and late pregnancy. Thus, each indicator detected biotin deficiency late in pregnancy, but assessment of biotin status for the two indicators conflicted early in pregnancy. Preliminary results from a trial assessing response of 3-HIA excretion to biotin treatment indicate that biotin status is indeed impaired both early and late in pregnancy.  (+info)

Mapping binding domains of kininogens on endothelial cell cytokeratin 1. (8/2828)

Human cytokeratin 1 (CK1) in human umbilical vein endothelial cells (HUVEC) is expressed on their membranes and is able to bind high molecular weight kininogen (HK) (Hasan, A. A. K., Zisman, T., and Schmaier, A. H. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3615-3620). New investigations have been performed to demonstrate the HK binding domain on CK1. Four overlapping recombinant (r) CK1 proteins were produced in Escherichia coli by a glutathione S-transferase gene fusion system. Biotin-HK specifically bound to rCK128 and rCK131 in the presence of Zn2+ but not to Deleted1-6rCK131. Recombinant CK128 and rCK131 also inhibited biotin-HK binding to HUVEC with IC50 of 0.4 and 0.5 microM, respectively. Alternatively, rCK114 and Deleted1-6rCK131 did not inhibit binding at concentrations >/=1 microM. Seven sequential 20 amino acid peptides of CK1 were prepared to cover the protein coded by exons 1-3. Only the first peptide (GYG20) coded by exon 1 significantly inhibited HK binding to HUVEC with an IC50 of 35 microM. Fine mapping studies isolated two overlapping peptides also coded by exon 1 (GPV15 and PGG15) that inhibited binding to HUVEC with IC50 of 18 and 9 microM, respectively. A sequence scrambled peptide of PGG15 did not block binding to HUVEC and biotin-GPV20 specifically bound to HK. Peptides GPV15 and PGG15 also blocked prekallikrein activation on endothelial cells. However, inhibition of PK activation by peptide PGG15 occurred at 10-fold lower concentration (IC50 = 1 microM) than inhibition of biotin-HK binding to HUVEC (IC50 = 10 microM). These studies indicate that HK binds to a region of 20 amino acids coded by exon 1 on CK1 which is carboxyl-terminal to its glycine-rich amino-terminal globular domain. Furthermore, HK binding to CK1 modulates PK activation on HUVEC.  (+info)

Holocarboxylase synthetase (HCS, human) and BirA (Escherichia coli) are biotin protein ligases that catalyze the ATP-dependent attachment of biotin to apocarboxylases. Biotin attachment occurs on a highly conserved lysine residue within a consensus sequence (Ala/Val-Met-Lys-Met) that is found in carboxylases in most organisms. Numerous studies have indicated that HCS and BirA, as well as biotin protein ligases from other organisms, can attach biotin to apocarboxylases from different organisms, indicating that the mechanism of biotin attachment is well conserved. In this study, we examined the cross-reactivity of biotin attachment between human and bacterial biotin ligases by comparing biotinylation of p-67 and BCCP87, the biotin-attachment domain fragments from human propionyl-CoA carboxylase and E. coli acetyl-CoA carboxylase, respectively. While BirA has similar biotinylation activity toward the two substrates, HCS has reduced activity toward bacterial BCCP87 relative to its native substrate, p-67.
U.S., Feb. 27 -- ClinicalTrials.gov registry received information related to the study (NCT03034707) titled Interference of Biotin Supplementation in Biotin-streptavidin Platforms for Hormone Testing on Jan. 17. Brief Summary: The B vitamin biotin is widely available as an over the counter supplement, often advertised and used to promote health of hair, skin and nails. Commercially available over the counter biotin supplements contain dose ranges up to 10 mg/day (ie 333 times higher than the recommended dietary allowance). The biotin molecule is also sometimes used as part of the lab technology to measure hormone and protein levels in the blood. It is possible that high doses of ingested biotin may interfere with accurate hormone or protein measurement using biotin related in vitro measurement systems. Such interference, if present, could lead to misdiagnosis. The study will analyze laboratory levels obtained with streptavidin-biotin assay systems while ingesting biotin in currently available ...
FIG. 5. Effects of the l-glutamate-producing condition of biotin limitation on l-glutamate production in AJ11024. Wild-type (solid circles) and AJ110214 (open circles) cells were cultured under biotin-limited conditions. Biotin concentrations are shown along the x axis. For biotin-limited conditions, seed cultures were prepared with 10, 30, 60, 100, and 300 μg of biotin liter−1, and 1 ml was inoculated into 20 ml of the main medium lacking biotin so that biotin was depleted during the main cultures. For biotin-rich conditions, a seed culture was prepared in 300 μg of biotin liter−1, and 1 ml was inoculated into 20 ml of the main medium containing 300 μg of biotin liter−1. The biotin concentration was calculated by dividing the total amounts of biotin supplied to the seed and main cultures by the volume of the main culture. The specific l-glutamate production rate (A), the specific glucose consumption rate (B), and the l-glutamate yield (C) are shown. Specific rates were calculated ...
Human SMVT protein is glycosylated, and that glycosylation is important for its function. The study also shows a role for the putative PKC-phosphorylation site Thr(286) of hSMVT in the PKC-mediated regulation of biotin uptake ...
The following proteins are candidates for maintaining biotin homeostasis in humans: the biotin transporters sodium-dependent multivitamin transporter (SMVT) and monocarboxylate transporter 1, the biotinyl-protein ligase holocarboxylase synthetase (HC
Does biotin work for hair growth? How effective is biotin when it comes to restoring the health of your hair? Have you ever wondered whats the biotin recommended dose for hair growth?. According to studies, the intake of biotin does have an immediate and noticeable effect on the health of your hair. Follicles seem to grow thicker, and roots seem to get stronger upon the intake of Biotin.. Aside from that, Biotin seems to also have a positive effect on the growth of the nails and the glowing of the skin.. Biotin, also known as Vitamin H, is a part of the B vitamin family. In the past, biotin was not really known to be a supplementary vitamin.. But with recent studies able to uncover the effect of biotin, particularly on hair growth, nail strength and skin cell regeneration, more and more people are now using biotin as a supplement.. Biotin is naturally-occurring, which means food intake can provide you with the basic amounts of biotin too. Biotin can come from these sources:. ...
An experiment was conducted to evaluate the effect of different levels of biotin on productive performance of Holstein dairy cow. In this experiment a change-over design with twelve multiparous cows, three rations and three periods was employed. Ingredients of the basal diet were alfalfa hay (24%) corn silage (16%) and concentrate (60%) on dry matter basis. The experimental diets 1 to 3 contained 0, 10 and 20 mg of biotin per day, respectively. The rations were fed to cows as Total Mixed Rations (TMR), but biotin was top-dressed on the a.m. allotment of ration. The cows were individually ad libitum and milked three times per day. Daily milk yielded was recorded and samples of the milk were taken once per week for determination of milk composition. Blood were taken in end of each period. Dry Matter Intake (DMI) and milk yield of cows were not affected by biotin. Also milk compositions were not affected by biotin. The average of Fat Corrected Milk (FCM) yield for 4% fat for rations contain 0, 10 and 20 mg
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
Biotin is one vitamin that has multiple benefits. With so many benefits, it would be hard to not go out and get some extra Biotin for yourself.. It does a great job of providing extra energy. This is because of the enzymes that work with carbs, fats, and protein metabolism need Biotin. Processes that go on in the deepest levels of our digestive system rely on Biotin. This is especially true when it comes to working with Amino Acids.. As mentioned above, Biotin can help with weak nails. If you are experiencing nails that crack or chip often, you might want to consider getting you some Biotin. It does not take much either to ensure stronger and healthier nails.. One of the most commonly known benefits of Biotin is its ability to strengthen and grow your hair. If you are not getting enough Biotin, it can lead to hair loss.. As mentioned above, pregnancy and Biotin are closely related. The vitamin is needed during pregnancy. The reason this is so important is that some studies have shown a lack of ...
Sensor performance of a dielectric filled silicon bulk acoustic resonator type label-free biosensor is verified with biotin-streptavidin binding interactions as a model system. The mass sensor is a micromachined silicon square plate with a dielectric filled capacitive excitation mechanism. The resonance frequency of the biotin modified resonator decreased 315 ppm when exposed to streptavidin solution for 15 min with a concentration of 10−7 M, corresponding to an added mass of 3.43 ng on the resonator surface. An additional control is added by exposing a bovine serum albumin (BSA)-covered device to streptavidin in the absence of the attached biotin. No resonance frequency shift was observed in the control experiment, which confirms the specificity of the detection. The sensor-to-sensor variability is also measured to be 4.3%. Consequently, the developed sensor can be used to observe in biotin-streptavidin interaction without the use of labelling or molecular tags. In addition, biosensor can be used
Sensor performance of a dielectric filled silicon bulk acoustic resonator type label-free biosensor is verified with biotin-streptavidin binding interactions as a model system. The mass sensor is a micromachined silicon square plate with a dielectric filled capacitive excitation mechanism. The resonance frequency of the biotin modified resonator decreased 315 ppm when exposed to streptavidin solution for 15 min with a concentration of 10−7 M, corresponding to an added mass of 3.43 ng on the resonator surface. An additional control is added by exposing a bovine serum albumin (BSA)-covered device to streptavidin in the absence of the attached biotin. No resonance frequency shift was observed in the control experiment, which confirms the specificity of the detection. The sensor-to-sensor variability is also measured to be 4.3%. Consequently, the developed sensor can be used to observe in biotin-streptavidin interaction without the use of labelling or molecular tags. In addition, biosensor can be used
One of the most popular methods of noncovalent conjugation is to make use of the natural strong binding of avidin or its derivative streptavidin to biotin. Each avidin molecule contains a maximum of four biotin binding sites thereby increasing the strength of their interaction with biotin. Depending on the functionality present on the biotinylation compounds, specific reactive groups on antibodies may be modified to create a avidin binding site. Amines, carboxylates, sulfhydryls, and carbohydrate groups can be specifically targeted for biotinylation through the appropriate choice of biotin derivative.. Avidin is a glycoprotein found in egg whites that contains four identical subunits of 16,400 Da each. The subunits each contain one binding site for biotin also known as vitamin H. The biotin interaction with avidin is the strongest noncovalent affinity known, exhibiting a dissociation constant of about 1.3×10-15M. Tryptophan and lysine residues in each subunit are involved in forming the binding ...
Acetyl-CoA carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the first committed step in fatty acid synthesis. The Escherichia coli enzyme is composed of a homodimeric biotin carboxylase, biotinylated biotin carboxyl carrier protein (BCCP), and an α2β2 heterotetrameric carboxyltransferase. Catalysis by acetyl-CoA carboxylase proceeds via two half-reactions. In the first half-reaction, biotin carboxylase catalyzes the ATP-dependent carboxylation of biotin, which is covalently attached to BCCP, to form carboxybiotin. In the second half-reaction, carboxyltransferase transfers the carboxyl group from carboxybiotin to acetyl-CoA to form malonyl-CoA. All biotin-dependent carboxylases are proposed to have a two-site ping-pong mechanism where the carboxylase and transferase activities are separate and do not interact. This posits two hypotheses: either biotin carboxylase and BCCP undergo the first half-reaction, BCCP dissociates, and then BCCP interacts with carboxyltransferase to
Regulation of the expression of the gene(s) coding for the 78-kD, biotin-containing subunit of [beta]-methylcrotonyl-coenzyme A carboxylase (MCCase) was investigated in different organs of tomato (Lycopersicon esculantus) plants. The specific activity of MCCase is highest in extracts from roots, followed in descending order by ripe and ripening fruits, stems, and leaves. The specific activity is 10-fold higher in roots than in leaves. However, the steady-state levels of the 78-kD subunit of MCCase and its mRNA are approximately equal in both roots and leaves. Instead, the difference in MCCase activity between these two organs is directly correlated to the biotinylation status of the enzymes biotin-containing subunit. Thus, the lower activity of MCCase in leaves is attributed to the reduced biotinylation of the biotin-containing subunit of the enzyme. Consistent with this model, a pool of nonbiotinylated enzyme is present in leaves, whereas the nonbiotinylated enzyme is undetectable in roots. ...
The attachment of biotin to various chemical sites, called biotinylation, can be used as an important laboratory technique to study various processes including DNA transcription and replication. Biotin itself is known to biotinylate histones, but is not found naturally on DNA.. Biotin binds very tightly to the tetrameric protein streptavidin, with a dissociation constant Kd in the order of 10-15 mol/L (Bonjour 1977, Green 1975) or 4x10-14 (Holmberg et al. 2005). Holmberg et al. (2005) note that the biotin-streptavidin system is the strongest noncovalent biological interaction known. This is often used in different biotechnological applications. Holmberg et al. showed how to utilize high temperatures to efficiently break the interaction without denaturation of the streptavidin.. In the biology laboratory, biotin is sometimes chemically linked, or tagged, to a molecule or protein for biochemical assays. The specificity of the biotin-streptavidin linkage allow use in molecular, immunological, and ...
The effects of biotin on ammonia concentration in blood and brain were evaluated in hyperammonemic rats and mice. Rats were injected with 5 mmol/kg BW of ammonium acetate, and mice were injected with 10 mmol/kg BW. Increases in blood ammonia levels in rats 15-30 min after ammonia loading were preven …
Gabapentin is absorbed from the intestines by an active transport process mediated via the large neutral amino acid transporter 1 (LAT1, SLC7A5), a transporter for amino acids such as L-leucine and L-phenylalanine.[11][95][100] Very few (less than 10 drugs) are known to be transported by this transporter.[101] Gabapentin is transported solely by the LAT1,[100][102] and the LAT1 is easily saturable, so the pharmacokinetics of gabapentin are dose-dependent, with diminished bioavailability and delayed peak levels at higher doses.[11] Gabapentin enacarbil is transported not by the LAT1 but by the monocarboxylate transporter 1 (MCT1) and the sodium-dependent multivitamin transporter (SMVT), and no saturation of bioavailability has been observed with the drug up to a dose of 2,800 mg.[103] The oral bioavailability of gabapentin is approximately 80% at 100 mg administered three times daily once every 8 hours, but decreases to 60% at 300 mg, 47% at 400 mg, 34% at 800 mg, 33% at 1,200 mg, and 27% at ...
Gabapentin is absorbed from the intestines by an active transport process mediated via the large neutral amino acid transporter 1 (LAT1, SLC7A5), a transporter for amino acids such as L-leucine and L-phenylalanine.[10][90][95] Very few (less than 10 drugs) are known to be transported by this transporter.[96] Gabapentin is transported solely by the LAT1,[95][97] and the LAT1 is easily saturable, so the pharmacokinetics of gabapentin are dose-dependent, with diminished bioavailability and delayed peak levels at higher doses.[10] Gabapentin enacarbil is transported not by the LAT1 but by the monocarboxylate transporter 1 (MCT1) and the sodium-dependent multivitamin transporter (SMVT), and no saturation of bioavailability has been observed with the drug up to a dose of 2,800 mg.[98]. The oral bioavailability of gabapentin is approximately 80% at 100 mg administered three times daily once every 8 hours, but decreases to 60% at 300 mg, 47% at 400 mg, 34% at 800 mg, 33% at 1,200 mg, and 27% at 1,600 ...
Looking for online definition of biotin vitamin in the Medical Dictionary? biotin vitamin explanation free. What is biotin vitamin? Meaning of biotin vitamin medical term. What does biotin vitamin mean?
Supports digestion & metabolism*. Try our hair gummy vitamins with biotin and collagen for longer hair and nail growth without messy nail biotin oil.* Not just another skin hair nail vitamin, weve formulated our vitamins for men and womens vitamins hair gummies with carefully selected, premium, natural ingredients, ensuring we bring you the very best hair growth products.* These hair supplements for hair growth women and men help moisturize dry damaged hair and add luster, shine and softness to hair, which helps prevent hair breakage and split ends, contributing to hair length.* Just two gummies a day supports a healthy scalp, hair growth, strong nails and a radiant complexion.* Got hair envy? Beautify yourself with LxH Hair Skin and Nails Vitamins Biotin and Collagen Gummies today!. BIOTIN VITAMINS FOR HAIR SKIN AND NAILS. These tasty hair vitamins for faster hair growth include the essential vitamin B7 biotin for hair growth for women and men.* They also feature hydrolyzed collagen for nails ...
Since favorable images of infection are obtained with radio-labeled nonspecific IgG, streptavidin has been considered as an alternative protein in this investigation. The advantage of streptavidin is that once localized it may be targeted with radiolabeled biotin. Studies were conducted in a mouse model with an Escherichia coli infection in one thigh. Indium-111-labeled streptavidin showed equivalent localization to the infection as that obtained with 111In-labeled polyclonal nonspecific IgG, however blood levels with streptavidin were lower at all time points; consequently, target-to-blood ratios were improved. Pretargeting with unlabeled streptavidin followed 3 hr later with 111In-labeled biotin showed equivalent localization in the target and reduced activity in all organs sampled. As such, infected thigh-to-normal thigh ratios were improved 3-fold for pretargeting versus either labeled IgG or streptavidin. Improvements in infected thigh-to-liver and blood ratios were greater than 8-fold. Only in the
Introduction. Have you ever been aware of Biotin being utilized to develop healthy hair? Well should you never receive enough Biotin in your diet you may go bald. So what is Biotin, why is it superior for your hair and just how do you receive it?. What Is Biotin. This is a associate of the vitamin B complex series. Especially its well-known as vitamin B-7.. Why Is It Great for Your Hair. This vitamin has occasionally been called truly the only vitamin your hair requirements. It is believed that this vitamin may avoid premature graying of the hair and can avoid baldness. It has been determined that Biotin is influential in assisting the body uses proteins and is equally significant for the development of keratin, an significant protein for the hair and nails.. It has been determined a shortage of the vitamin can really result you to go bald. But unlike guy or woman pattern baldness where the hair follicle really dies and makes re-growing hair difficult, folks who lost their hair due to a ...
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Biotin Agarose Resin is used for purification or removal of avidin or streptavidin samples. Biotin is immobilized through a spacer arm by means of covalent binding that minimize leakage. The binding is very strong, making it suitable for non-reversible b
Avidin is a basic charged glycoprotein present in the egg white and in some extent in tissues of various animals. Avidin is a homotetrameric protein that contains 4 identical subunits which bind to Biotin with high extent of affinity and specificity consisting of 128 amino acids and has a molecular mass of about 67K Daltons. Avidin-Biotin is a modified form of affinity purified avidin that combines the high affinity specific activity of the native egg white avidin to biotin molecule together with a very low background of the streptavidin produced by the bacteria Streptomyces avidinii.
TY - JOUR. T1 - Epigenetic regulation of chromatin structure and gene function by biotin. AU - Hassan, Yousef I.. AU - Zempleni, Janos. PY - 2006/7/6. Y1 - 2006/7/6. N2 - Covalent modifications of histones are a crucial component of epigenetic events that regulate chromatin structures and gene function. Evidence exists that distinct lysine residues in histones are modified by covalent attachment of the vitamin biotin, catalyzed by biotinidase and holocarboxylase synthetase. Biotinylation of histones appears to be conserved across species. The following biotinylation sites were identified using both MS and enzymatic biotinylation of synthetic peptides: K9, K13, K125, K127, and K129 in histone H2A; K4, K9, and K18 in histone H3; and K8 and K12 in histone H4. Evidence was provided that biotinylated histone H4 is enriched in pericentromeric heterochromatin, and that biotinylation of histone H4 participates in gene silencing, mitotic condensation of chromatin, and the cellular response to DNA damage. ...
In biochemistry, biotinylation is the entire process of covalently attaching biotin to a protein, nucleic acid or other molecule. Biotinylation is quick, certain and is not likely to perturb the natural operate from the molecule due to the small dimension of biotin (MW = 244.31 g/mol). Biotin binds to streptavidin and avidin with an especially superior affinity, quick on-price, and higher specificity, and these interactions are exploited in many areas of biotechnology to isolate biotinylated molecules of desire. Biotin-binding to streptavidin and avidin is resistant to extremes of heat, pH and proteolysis, earning capture of biotinylated molecules attainable in numerous types of environments ...
The CD19 CAR Detection Reagent (Biotin) has been developed for the detection of transduced T cells that are engineered to express CD19-specific chimeric antigen receptors (CAR) on the cell surface, which recognize human CD19 antigen. The CD19 CAR Detection Reagent (Biotin) is an antigen based detection reagent conjugated to biotin. It contains a recombinantly expressed fusion protein consisting of the human CD19 extracellular domains and a specifically mutated human IgG1 Fc region. The engineered CD19 CAR T cells can be detected via the recognition of the CD19 protein, and identified by flow cytometry via anti-biotin fluorochromes. The mutated human IgG1 Fc region of the CD19 CAR Detection Reagent abolishes their binding to Fcγ receptors. This allows for background-free analysis and eliminates the need for additional blocking steps, such as using a FcR blocking reagent. - Ireland
Biotin 300 mcg Tablets Dietary Supplement Suitable for Vegetarians - Sugar, Salt and Starch Free Essential B Vitamin Suggested Use: As a dietary supplement for adults, one (1) capsule daily, preferably at mealtime, or as directed by a healthcare practitioner. Serving Size 1 Tablet Amount Per Tablet Ingredients: Biotin 300 mcg (100%) Calcium (as dicalcium phosphate) 80 mg (8%) To assure freshness and potency, store at room temperature 15-30C (59-86F). Store away from heat, light and moisture. Other Ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Stearic Acid, Silica, Vegetable Magnesium Stearate. Product Notes: If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement. Solgars Biotin Tablets are free of corn, yeast, wheat, soy and dairy products and are form
This bundle involves a single bottle of Andalou Naturals Lavender and Biotin Total Volume Shampoo and 1 bottle of Andalou Naturals Lavender and Biotin Complete Volume Conditioner, eleven.five fl. oz each.About the Shampoo and ConditionerAndalou Naturals Fruit Stem Cell Science improves hair follicle longevity and vitality for healthful hair from root to tip.Lavender gently refreshes, stimulating follicles and circulation. Biotin B-complicated infuses crucial protein for thicker, fuller strands, improved power, texture and manageability for optimum volume and silky sheen.Apple + Grape Stem CellsPhytoCellTec¨ patented liposomal process encapsulates plant stem cells at peak potency, stabilizing important anti-aging and antioxidant positive aspects up to 1000x higher than the unique bioactive ingredient. Award-winning Malus Domestica (Apple) and Solar Vitis (Grape) Stem Cells give ÔuniversalÕ cells to energize skin cell function for enhanced immunity, longevity and vitality.Age Defying Fruit Stem
HOLIKA HOLIKA Biotin Damage Care Shampoo 400ml at best price from at Beauty Box Korea, HOLIKA HOLIKA Biotin Damage Care Shampoo 400mlHOLIKAHOLIKA HOLIKA HOLIKA Biotin Damage Care Shampoo 400ml Gives damaged hair protein with biotin for healthy glow hair. Fine bubbles give gentle soft moisture hair cleansing. No addition of silicon to reduce scalp irritation giving hair nutrition ingredient higher absorption for healthy hair care. Refreshing floral scent with long lasting.   How to Use Wet hair on water, use right amount of shampoo to lather bubbles onto hair and scalp, rinse off with lukewarm water thoroughly. Worldwide shipping. Genuine product guaranteed.Newly produced Korean Cosmetics. Free Gift for All Orders. Find more Korean cosmetics,K-Beauty items & Asian skincare products at best price, Fast Shipping Worldwidely, Customized Product Request,Wholesale Supply. Great selection of the best Korean Skin Care, makeup and cosmetics including hair & bath as well as the necessary
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Biotin is an essential vitamin in plants and mammals, functioning as the carbon dioxide carrier within central lipid metabolism. Bacterial pimeloyl-CoA synthetase (BioW) acts as a highly specific substrate-selection gate, ensuring the integrity of the carbon chain in biotin synthesis. BioW catalyzes the condensation of pimelic acid (C7 dicarboxylic acid) with CoASH in an ATP-dependent manner to form pimeloyl-CoA, the first dedicated biotin building block. Multiple structures of Bacillus subtilis BioW together capture all three substrates, as well as the intermediate pimeloyl-adenylate and product pyrophosphate (PPi), indicating that the enzyme uses an internal ruler to select the correct dicarboxylic acid substrate. Both the catalytic mechanism and the surprising stability of the adenylate intermediate were rationalized through site-directed mutagenesis. Building on this understanding, BioW was engineered to synthesize high-value heptanoyl (C7) and octanoyl (C8) monocarboxylic acid-CoA and C8 ...
Står dette på nettsiden: Biotin Alone Is Not Enough to Correct Poor Horn Quality in Most Cases Its only one of many nutrients needed by the adult horse. In fact, the adult horse is said to have no dietary requirement for biotin unless under stress conditions such as intense work, traveling, being stabled for long periods or being fed a low-quality diet. And even under these conditions, biotin deficiency is relatively rare, and is usually accompanied by many dietary deficiencies. Biotin Supplementation Horses which respond to biotin supplementation alone (approximately 5% of those with poor-quality horn) show large holes in the outermost layer of the wall when viewed under a microscope. The inner layers of the wall were usually not affected. However; our recent research indicates that an increased amount of biotin helps the hoof in the presence of laminitis. Methionine, Proline, Glycine and Glutamine are some of the major building blocks of healthy connective tissue, or collagen. Copper and ...
1. The reaction between avidin and biotin was found to be exothermic, DeltaH being -20.3kcal./mole of biotin bound. The corresponding value of DeltaH for streptavidin was -23kcal./mole. 2. The heat evolved was independent of the pH (between 5 and 9), of the buffer (borate or ammonia) and of the fractional saturation of the avidin with biotin. 3. The entropy change for the reaction was zero, and it is suggested that the entropy increase to be expected from hydrophobic interactions was counterbalanced by a decrease in entropy accompanying the formation of buried hydrogen bonds. 4. Modification of the potential hydrogen-bonding sites of the imidazolidone ring led to a decreased heat output and a positive entropy of reaction.. ...
2000 Da) were able to fill all three of the remaining avidin-binding sites, while only one molecule of biotinylated PEG5000 or stem cell factor bound to each avidin. The resulting biotin−avidin−biotin linkages were stable for prolonged periods under continuous perfusion, even in the presence of excess free biotin. Hematopoietic M07e cells bound to immobilized peptide ligands for α5β1 (cyclic RGD) and α4β1 (cylic LDV) integrins in a DPB-dose-dependent manner, with near-maximal binding to cylic LDV for surfaces containing 1% DPB. Multiple ligands were adsorbed in a controlled manner by incubating NeutrAvidin with the respective ligands in the desired molar ratio and then adding the resulting complexes to DPB-containing surfaces. Cell adhesion to surfaces containing both cylic LDV and cyclic RGD increased in an additive manner compared to that for the individual ligands. The bioactivity of adsorbed biotinylated stem cell factor was retained, as demonstrated by DPB-dose-dependent M07e cell ...
The avidin-biotin system is a technique for studying the interaction between two biomolecules in an indirect manner, as follows: Biotin is chemically coupled to a binder molecule (e.g., a protein, DNA, hormone, etc.) without disturbing the interaction with its target molecule; avidin is then used to sandwich between the biotinylated binder and a reporter molecule or probe. This allows for a variety of tasks, including localization and identification of the binder or target molecule. Consequently, the avidin-biotin system can frequently replace radioactive probes. Together with Ed Bayer, Wilchek established the Avidin-biotin system as a powerful tool in biological sciences. Early in the 1970s, they exploited Avidin as a probe and developed new methods and reagents to biotinylate antibodies and other biomolecules. Today, the system is applied in research and diagnostics as well as medical devices and pharmaceuticals. Examples include western blot, ELISA, ELISPOT and pull-down assays.[12] More ...
Fluorescent Dyes , Biotins and Streptavidins , Streptavidin, recombinant; Streptavidin is a nonglycosylated, tetrameric protein, with each subunit able to bind a single molecule of the vitamin biotin. Streptavidin-biotin bond is the strongest known non-covalent interaction with Kd ~10-15 M. Because streptavidin lacks any carbohydrate modification and has a near-neutral pI, it has the advantage of much lower nonspecific binding than avidin. Streptavidin is broadly used in various applications such as immunoassays, histochemistry, FISH (Fluorescence In Situ Hybridization), flow cytometry, microarrays and blot analysis.
The ABC method is an indirect method of immunohistochemistry. It stands for the Avidin-Biotin Complex Method. Firstly, the tissue of interest is sectioned and is incubated with a primary antiserum that targets the antigen we would like to locate in the tissue section. An antiserum is a serum containing antibodies such as agglutinins and antitoxins. This antiserum is known as the primary antibody and is injected into the tissue to target the antigen and causes an antibody-antigen reaction. After the primary antibody is inserted. A secondary labeled antibody is added, namely a biotinylated antibody. The secondary antibody reacts with the first antibody and launches a large mass of biotin into the area in which the antigen is situated. The secondary antibody is reacts in an opposite manner to the primary antibody. The secondary antibody does not have the intention in reacting with the antigen. The addition of the avidin biotin enzyme complex causes binding to the secondary antibody. The avidin ...
Recent work in this laboratory has shown that hydnocarpic acid (HA), a principal constituent of chaulmoogra oil, inhibits multiplication in vitro of a number of mycobacterial species. This activity of HA was not shared by several straight-chain fatty acids and by dihydrochaulmoogric acid. A study of the interaction of HA with biotin has been undertaken, based on a structural analogy between biotin and the cyclopentenyl fatty acid. The multiplication of a strain of Mycobacterium intracellulare susceptible to 2 μg of HA/ml was measured turbidimetrically in Dubos medium, in the presence and absence of biotin and several other compounds. Biotin and, to a lesser extent, adenine plus guanine, palmitic acid, and linoleic acid antagonized growth inhibition by HA. Desthiobiotin, thioctic acid, and succinic acid did not block inhibition of bacterial multiplication by HA. HA may act by blocking the coenzymatic activity of biotin, or it may inhibit microbial biotin synthesis. Resumption of multiplication ...
High dose biotin. Biotin is an essential coenzyme for a variety of carboxylation reactions, including the activation of acetylCoA carboxylase, a crucial enzyme in the normal, healthy synthesis of myelin.* Gluten Free! Product Info Serving Size: 1 Capsules Servings Per Container: 90 Each Capsule contains Biotin 100mg Ot
Peptides , Histones , Histone H3 Peptides , [Cit17]-Histone H3 (1-21)-GGK(Biotin); This peptide is histone H3 (1-21) with deimination at Arg17, converting it to Cit (Citrulline). It is biotinylated through a C-terminal GGK linker. Deimination by peptidyl arginine deiminase 4 (PADI4) blocks methylation by the CARM1 methyltransferase and inhibits transcriptional activation. Provided at |95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.; ARTKQTARKSTGGKAP-Cit-KQLAGG-K(Biotin); H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Cit-Lys-Gln-Leu-Ala-Gly-Gly-Lys(Biotin)-OH
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5-adenylate (BirA-bio- 5-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (320 aa ...
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5-adenylate (BirA-bio- 5-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (319 aa ...
0050] Afterwards, the ssDNA was separated from the proteins bound thereto. In this context, the ssDNA and the proteins bound thereto were eluted with elution buffer (20 mM Tris, 50 mM NaCl, 5 mM KCl, 5 mM MgCl2, 0.01% tween 20, 300 mM imidazole, pH 8.0). The ssDNA eluate was precipitated in ethanol, dissolved in 60 μL of distilled water, and used as a template for PCR amplification using the 5 primer and the biotin-conjugated 3 primer in the presence of i-pfu polymerase (Intron Biotechnology, Korea). To isolate ssDNA for selection, the biotin-conjugated PCR product was incubated for one hour with streptavidin-coated magnetic beads in a coupling buffer (5 mM Tris-HCl, 0.5 mM EDTA, 1 M NaCl, 0.005% Tween 20, pH 7.5), followed by incubation with 100 μL of 100 mM NaOH for 5 min to separate only ssDNA. The ssDNA was obtained using an external magnet ...
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OGX Biotin & Collagen Shampoo helps to infuse nutrients into every strand and creates the appearance of thicker, fuller, healthier looking hair. OGX Thick & Full Biotin & Collagen Shampoo Why You Want It... Discover thicker, fuller and more abundant looking hair! This hair thickening shampoo helps to thicken and texturize any hair type! Immerse your thin, skinny strands in this super volumizing blend to help create fuller looking, shiny hair! An exclusive blend with Vitamin B7 biotin,..
- Promotes Healthy Hair and Strong Nails - Supports Cellular Energy Production - Easy-to-Swallow Tablets - 100% Vegetarian Biotin is an important B-vitamin that provides dietary support for healthy hair and nails, as well as energy production. By supporting the matrix of hair and nails, Biotin promotes shiny, lustrous hair and strong, resilient nails. Directions: Take 1 tablet, one time daily, with a meal. Supplement Facts: Serving Size: 1 Tablet Amount Per Serving - % Daily Value Biotin 1,000 mcg 333% Calcium 46 mg 5% (from Dibasic Calcium Phosphate) * Daily Value (DV) Not Established Other Ingredients: Cellulose, Stearic Acid, Silica, Magnesium Stearate, Methylcellulose, Cellulose Gum, Glycerin. NO Yeast, Wheat, Corn, Milk, Egg, Soy, Glutens, Artificial Colors or Flavors, Added Sugar, Starch or Preservatives Other Information: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are
Biotin is recommended by AAFCO to be included in feline diets at a minimum level of 0.07 mg/kg on a dry matter basis throughout ... Biotin can be provided in feline diets by adding cooked eggs, liver, milk, legumes or nuts. Microorganisms living in the ... Biotin does not need to be added unless diet contains antimicrobial or antivitamin compounds. (Removed in 2014) methionine may ... Biotin. InBowman, B.A. and Russell, R.M. (Editors) "Present Knowledge in Nutrition", ninth edition, International Life Science ...
"Synthesis of Biotin". Retrieved 2010-05-22. CS1 maint: discouraged parameter (link) "Dr. Moses W. Goldberg (obituary)". The New ... With Leo Sternbach, Goldberg patented a process for synthesizing biotin in 1949. He obtained numerous other patents while ... developed a process for the synthesis of biotin (a B vitamin) in 1949. Moses Wolf Goldberg was born in Rūjiena, Latvia in 1905 ...
Baugh CM, Malone JH, Butterworth CE (February 1968). "Human biotin deficiency. A case history of biotin deficiency induced by ... It binds very tightly to biotin (vitamin B7) and can cause deficiency of B7 in animals and, in extreme cases, in humans. A ...
Pinon V, Ravanel S, Douce R, Alban C (2005). "Biotin synthesis in plants. The first committed step of the pathway is catalyzed ... 8-amino-7-oxononanoate synthase catalyzes the first committed step in plant biotin synthesis. MurA catalyzes the first ...
Attachment of a tetramethylrhodamine or a biotin via the AEEA linker to ShK's N-terminus did not increase specificity for Kv1.3 ... and biotin is neutral. Subsequent studies with other analogues suggest that the negatively charged F6CA likely interacts with ...
May 2009). "Biotin: The Chiral Challenge". CHIMIA International Journal for Chemistry. 63 (5). pp. 265-269. Pearce, Jeremy. " ... With Moses Wolf Goldberg, Sternbach also developed "the first commercially applicable" method for synthesizing biotin. ...
Alban C, Job D, Douce R (2000). "Biotin metabolism in plants". Ann Rev Plant Physiol Plant Mol Biol. (2000), 5: 17-47. doi: ... Similarly, he will elucidate the biosynthesis pathways of biotin and tetrahydrofolic acid (vitamin B12). The last part of ...
Symptoms of biotin deficiency include alopecia and achromotrichia. A clinical study of biotin showed the importance of biotin ... The supplementation of biotin cannot reverse affects caused by deficiency, but as soon as supplementation is given and biotin ... For example, the shaft development is not greatly affected by biotin access. During the last stage, the amount of biotin ... Throughout the hair development, most stages of growth are completed, but it was found that in the last stage, where biotin ...
Because no biotin was released following their preparation of the sample with perchloric acid, they concluded that biotin is ... By producing a crystallized pig heart propionyl carboxylase, Kaziro and his team were able to observe the effects of biotin and ... Kaziro and his wife had two children, Shoko Kaziro, his first born named after his research on crystallizing biotin dependent ... They also found that their highly purified pig heart propionyl carboxylase enzyme contained significant amounts of biotin. ...
Molecular structure of biotin. Results of two independent crystal structure investigations. J. Am. Chem. Soc., 98(7), 1920-1926 ...
the biotin biosynthesis pathway: the mechanism of several of the enzymes involved has been deciphered and various inhibitors ... Biotin synthase mechanism: An overview. Biochemical Society Transactions, 2005, 33, 820 - 823. B. Rüdiger, B. Tse Sum Bui, V. ... A total synthesis of biotin based on the stereoselective alkylation of sulfoxides. J. Amer. Chem. Soc., 1978, 100, 1558. 1961: ... Iron-sulfur clusters of biotin synthase in vivo: a Mössbauer study. Biochemistry, 2002, 41, 15000-15006. E. Davioud, A. ...
The native enzyme to biotin ratio has been determined to be one mole native enzyme to 4 moles biotin. The N1 of biotin is ... The biotin-binding pocket of PCC is hydrophobic and highly conserved. Biotin and propionyl-CoA bind perpendicular to each other ... Optimum pH was shown to be between 7.2 and 8.8 without biotin bound. With biotin, optimum pH is 8.0-8.5. The normal catalytic ... The alpha subunit of PCC contains the biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains. A domain ...
These conditions respond to biotin. Forms include: Holocarboxylase synthetase deficiency - neonatal; Biotinidase deficiency - ...
It employs one cofactor, biotin. Allophanate hydrolase Roon RJ; Levenberg B (1970). ATP-Urea amidolyase (ADP) (Candida utilis ...
It employs one cofactor, biotin. Seubert W, Fass E, Remberger U (1963). "Untersuchungen uber den bakteriellen Abbau von ...
Enzymatic biotinylation is most often carried out by E. coli biotin holoenzyme synthetase, also known as biotin ligase (BirA, ... is labeled with sufficient biotin molecules to purify or detect the molecule, but not so much that the biotin interferes with ... A protein fused by BCCP can be recognized by biotin molecules in vivo and attach to it. A few other small tags have been used ... The biotin tag can be used in affinity chromatography together with a column that has avidin (or streptavidin or neutravidin) ...
Izumi Y, Sato K, Tani Y, Ogata K (1975). "7,8-Diaminopelargonic acid aminotransferase, an enzyme involved in biotin synthesis ... This enzyme participates in biotin metabolism. It employs one cofactor, pyridoxal phosphate. As of late 2007, 11 structures ... An enzyme in the biotin biosynthetic pathway". J. Biol. Chem. 250: 4029-4036. Biology portal v t e. ... an enzyme involved in biotin synthesis, from Brevibacterium divaricatum". Agric. Biol. Chem. 37 (11): 2683-2684. doi:10.1271/ ...
... biotin-responsive; 607483; SLC19A3 Basal laminar drusen; 126700; HF1 BCG and salmonella infection, disseminated; 209950; IL12B ...
This enzyme participates in biotin metabolism. Izumi Y, Morita H, Sato K, Tani Y, Ogata K (1972). "Synthesis of biotin-vitamers ... Izumi Y, Morita H, Tani Y, Ogata K (1974). "The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by ...
Toh H, Kondo H, Tanabe T (August 1993). "Molecular evolution of biotin-dependent carboxylases". Eur. J. Biochem. 215 (3): 687- ... This domain carries out the following reaction: transcarboxylation from biotin to an acceptor molecule. There are two ... In molecular biology, proteins containing the carboxyl transferase domain include biotin-dependent carboxylases. ...
... such as biotin deficiency; and particular classes of prescription and over-the-counter medication. An adult who is compelled to ...
"Biotin, Fact Sheet for Health Professionals". Office of Dietary Supplements, US National Institutes of Health. 3 October 2017. ...
Biotin is an important water-soluble nutrient that aids in the metabolism of fats, carbohydrates, and proteins. Biotin ... and dietary deficiency of biotin) can be quite severe. A 2004 case study from Metametrix detailed the effects of biotin ... there is no significant difference between dietary biotin deficiency and genetic loss of biotin-related enzyme activity. In ... Biotin is a vitamin that is chemically bound to proteins. (Most vitamins are only loosely associated with proteins.) Without ...
0.2 mg each biotin and riboflavin; and 0.005 mg cyanocobalamin) Atlas RM, Snyder JW (2006). Handbook of Media for Clinical ...
The enzyme breaks down biotin amides, releasing free biotin and the amine. The main substrate is biocytin, or biotin linked to ... Biotinidase removes biotin from biocytin and makes it available to be reused by other enzymes. Biotin, sometimes called vitamin ... It is also capable of breaking apart biotin esters. This enzyme allows the body to use and to recycle the B vitamin biotin, ... sometimes called vitamin H. Biotinidase extracts biotin from food because the body needs biotin in its free, unattached form. ...
Yang H-C; Tani Y; Ogata K (1970). "Synthesis of biotin vitamers from biotin diaminocarboxylic acid or 7,8-diaminopelargonic ... This enzyme participates in biotin metabolism. As of late 2007, 14 structures have been solved for this class of enzymes, with ...
For example, avidin is a protein in raw egg whites that inhibits the absorption of biotin; it is deactivated by cooking. ... Roth KS (September 1981). "Biotin in clinical medicine--a review". The American Journal of Clinical Nutrition. 34 (9): 1967-74 ... microorganisms in the gut flora produce vitamin K and biotin; and one form of vitamin D is synthesized in skin cells when they ... biotin), vitamin B9 (folic acid or folate), vitamin B12 (cobalamins), vitamin C (ascorbic acid), vitamin D (calciferols), ...
"Biotin - Fact Sheet for Health Professionals". Office of Dietary Supplements, US National Institutes of Health. 8 December 2017 ... and Pyruvate carboxylase require biotin as a cofactor. These enzymes are involved in various biogenic pathways. In the EC ...
There is no evidence for biotin. Evidence for most other products is also insufficient. There was no good evidence for gingko, ... especially for products that contain biotin. Type 1 and 2 5α reductase enzymes are present at pilosebaceous units in papillae ...
Eisenberg MA, Star C (October 1968). "Synthesis of 7-oxo-8-aminopelargonic acid, a biotin vitamer, in cell-free extracts of ... This enzyme participates in biotin metabolism. It employs one cofactor, pyridoxal phosphate. This enzyme belongs to the family ... phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies ... Escherichia coli biotin auxotrophs". Journal of Bacteriology. 96 (4): 1291-7. doi:10.1128/JB.96.4.1291-1297.1968. PMC 252447. ...
Sources of Biotin. Food. Many foods contain some biotin. Foods that contain the most biotin include organ meats, eggs, fish, ... Biotin Deficiency. Biotin deficiency is rare [12,19], and severe biotin deficiency in healthy individuals eating a normal mixed ... in the intestinal lumen to release free biotin [6]. The free biotin is then absorbed in the small intestine, and most biotin is ... Most biotin in foods is bound to protein, although some dietary biotin is in the free form [1,3,4,6]. Gastrointestinal ...
... has role prosthetic group (CHEBI:26348) biotin (CHEBI:15956) is a biotins (CHEBI:51570) biotin (CHEBI: ... biotin (CHEBI:15956) has role B vitamin (CHEBI:75769) biotin (CHEBI:15956) has role coenzyme (CHEBI:23354) biotin (CHEBI:15956 ... biocytin (CHEBI:27870) has functional parent biotin (CHEBI:15956). biotin amide (CHEBI:16615) has functional parent biotin ( ... biotin (CHEBI:15956) has role Escherichia coli metabolite (CHEBI:76971) biotin (CHEBI:15956) has role Saccharomyces cerevisiae ...
Biotin deficiency can cause thinning of hair and rash around the eyes, nose, and mouth. ... Biotin is a vitamin found in foods like eggs, milk, and bananas. ... Taking biotin can help treat low blood levels of biotin. It can ... Biotin is a vitamin. Foods such as eggs, milk, or bananas contain small amounts of biotin.. Biotin is used for biotin ... Smoking: People who smoke might have low biotin levels and may need a biotin supplement.. Laboratory tests: Taking biotin ...
Biotin Description Biotin is a member of the B complex family, but is not actually a vitamin. It is a coenzyme that works with ... Biotin Medical Discoveries COPYRIGHT 1997 Thomson Gale. Biotin. Biotin is a member of the vitamin B family. It is water soluble ... Sources of biotin. Biotin is found in small quantities in many foods. Bacteria in the large intestine also make biotin. Unlike ... Biotin deficiency. Biotin deficiency is very rare worldwide. Only a few conditions are known to cause biotin deficiency. Two ...
Deficiency of biotin is also known to cause skin rash. This symptom occurs because biotin is necessary to build healthy fats in ... Nuts, root vegetables, and eggs are among our best sources of biotin. Each can contain more than a quarter of your daily biotin ... Most importantly, we see that biotin plays key roles in fat and sugar metabolism, roles that make deficiency of biotin show up ... Some of the difficulty we have in determining the food content of biotin lies in the shortcomings of our methods for biotin ...
52781 To read more about this Biotin hair gro... ... Biotin Review Before and After - Duration: 3:00. Sheriza R ... Biotin For Hair Growth, Strong Nails and Weight loss -Does it work? My Experience - Duration: 5:50. beautyklove 201,089 views ... Organix Biotin and Collagen Shampoo and Conditioner Review - Duration: 4:30. Sheriza R 167,741 views ... DIY Biotin Shake for Healthier and Thicker Hair - Duration: 4:29. Luxy Hair 381,584 views ...
WebMD explains the supplement biotin, a coenzyme also known as vitamin H, that is sometimes used for hepatitis, diabetes, ... What are the risks of taking biotin? Biotin is a coenzyme and a B vitamin. It is also known as vitamin H. Because biotin is ... Genuine biotin deficiency is quite rare.. Pregnant women sometimes have low levels of biotin, so some take biotin supplements. ... However, most people dont need biotin supplements. We get biotin in foods naturally. Our bodies also recycle the biotin weve ...
Learn more about the benefits and side effects of biotin in this article. Also, we tell you the best way to include biotin in ... Biotin is a B vitamin that has important benefits for hair, nails, skin, and many other aspects of good health. ... Can biotin help treat MS? Biotin is a vitamin also known as B7. It assists the body in converting food to energy and can help ... Biotin may benefit brittle nails (7).. In one study, 8 people with brittle nails were given 2.5 mg of biotin per day for 6 to ...
Biotin supplements are considered harmless, so theres no reason not to try them for psoriasis. But what does scientific ... Can biotin help?. We get biotin from foods such as eggs and avocado, so deficiency is rare, though not unheard of. Signs of ... What else can biotin help?. Biotin is a B vitamin (B-7), but its also sometimes called vitamin H. It supports healthy cell ... Biotin has been shown to stop baldness in limited cases, and to help smooth brittle fingernails. A 2015 study indicated that ...
BIOTIN, COENZYME R, HEXAHYDRO-2-OXO- [3AS-(3AA ,4B,6AA)]- 1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID, VITAMIN B7, VITAMIN H, [ ...
Biotin - formulated with 5,000 mcg per serving in strawberry flavor for the support of hair, skin, and nails* ... Its available in Multi-vitamins for children and adults, Vitamin C, Biotin, Melatonin, and Omega-3 with DHA to support healthy ... GummYum!, Biotin 1 Results (showing 1 - 1) Visit Manufacturers Website » @media(max-width: 576px){ .brands-banner-collapsible ...
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Biotin is a water-soluble B vitamin that helps you transform fat, protein and carbohydrates in your food to energy needed by ... Biotin is found in a wide variety of natural foods. Egg yolk, liver and wheat bran are rich sources. Generally, the more ... Thus far, no ill effects have been reported by humans eating large amounts of biotin. However, studies have not specifically ... In people consuming a healthy diet, biotin deficiency is rare. However, deficiencies have been reported in patients on tube ...
... http://www.chiro.org/nutrition/ABSTRACTS/Biotin_Monograph.shtml ... biotin (or simply D-biotin ). Pharmacokinetics Oral biotin is completely absorbed, even at high, pharmacological doses. Urinary ... suggesting 100-percent bioavailability of orally administered biotin. [2] Percutaneous absorption of biotin from a biotin- ... Biotin: Monograph This section is compiled by Frank M. Painter, D.C.. Send all comments or additions to: [email protected] ...
... Prescriber Update 40(3): 53-54. September 2019. Key Messages *Biotin may interfere with some laboratory tests, ... Biotin may interfere with laboratory tests that are based on biotin technology, leading to either falsely decreased or falsely ... and nail growth contain biotin at levels that may interfere with laboratory tests1,2. Biotin may be labelled as Vitamin B7 or ... Many laboratory tests that use biotin technology are potentially affected, including but not limited to cardiovascular ...
The vitamin Biotin improves the quality of keratin structures in cosmetic applications and hence has a positive effect on fine ... The vitamin Biotin improves the quality of keratin structures in cosmetic applications and hence has a positive effect on fine ... D-Biotin Safety Data Sheet. SAFETY DATA SHEET for the vitamin D-Biotin Safety according to Regulation (EC) No. 1907/2006. ... Although a key reputation for biotin is in hair-loss products, a combination of biotin and STAY-C® 50(patent granted) also ...
The biotin / lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic ... Biotin/lipoyl attachment (IPR000089). Short name: Biotin_lipoyl Overlapping homologous superfamilies *Single hybrid motif ( ... The importance of methionine residues for the catalysis of the biotin enzyme, transcarboxylase. Analysis by site-directed ...
... and biotin (B7) are types of B vitamins. They are water-soluble, which means that the body cant store them. If the body cant ... Pantothenic acid and biotin are needed for growth. They help the body break down and use food. This is called metabolism. They ... Lack of pantothenic acid is very rare, but can cause a tingling feeling in the feet (paresthesia). Lack of biotin may lead to ... Pantothenic acid (B5) and biotin (B7) are types of B vitamins. They are water-soluble, which means that the body cant store ...
In this article, we look at the effectiveness, risks, and alternatives to biotin for psoriasis. ... Some people use supplements of biotin, or vitamin B-7, to manage the symptoms of psoriasis. ... Other benefits of biotin. Biotin may help hair growth.. Biotin is essential in the human diet because it helps break down fats ... What you should know about biotin-rich foods Biotin helps maintain healthy hair, skin, and nails, among other functions. Biotin ...
Cardiac troponin assays may be influenced by ingestion of over-the-counter biotin, leading to overestimation or underestimation ... Control 0 ng/mL Biotin. Postdose 1-h 140 ng/mL Biotin. Postdose 2-h 100 ng/mL Biotin. Postdose 4-h 50 ng/mL Biotin. Control 0 ... Control 0 ng/mL Biotin. Postdose 1-h 140 ng/mL Biotin. Postdose 2-h 100 ng/mL Biotin. Postdose 4-h 50 ng/mL Biotin. Control 0 ... ng/mL Biotin. Postdose 1-h 140 ng/mL Biotin. Postdose 2-h 100 ng/mL Biotin. Postdose 4-h 50 ng/mL Biotin. ...
What Is Biotin?. Biotin, also known as B7, is a crucial vitamin for the body. It has gained a powerful reputation for helping ... Advantages of Using Biotin Shampoo and Conditioner. There has been a recent increase in the use of biotin is hair care products ... Of course, youll want to make sure the product you use containing biotin is all natural, as biotin will be ineffective when ... Pair these amazing advantages this with a biotin conditioner, to combat dryness and breakage on your ends. Biotin conditioner ...
Other names: Biotin, N,N-(trimethylsilyl)-, trimethylsilyl ester; Trimethylsilyl 5-[2-oxo-1,3-bis(trimethylsilyl)hexahydro-1H- ... Biotin, 3TMS derivative. *Formula: C19H40N2O3SSi3 ...
This article discusses biotin deficiency caused by deficiency of the enzyme biotinidase (see also Biotinidase Deficiency). ... Biotin deficiency is a rare nutritional disorder caused by a deficiency of the water-soluble B vitamin termed biotin. ... The biotin-avidin bond is essentially irreversible; as a result, biotin is not liberated from food, and the biotin-avidin ... Free biotin is released from biocytin and biotin-oligopeptides by the action of intestinal biotinidase. Free biotin is then ...
... Mara Michelle Casar mmc9 at acpub.duke.edu Tue Jan 30 08:47:29 EST 1996 *Previous message: ... Lou Hom wrote... , Does anyone know of any fluorescent molecules that tolerate conjugation to , biotin? Im wondering if there ... I havent come across anything talking about fluorescently-labeled biotin, though. You could check the Molecular Probes catalog ... are any biotin-fluorophore-protein , conjugates on record anywhere. Im about to start feeding a protein to cells to see how it ...
... a protein that binds biotin strongly. Once a biotin-avidin complex forms, the bond is essentially irreversible. The biotin- ... Biotin deficiency. Biotin deficiency is a rare metabolic genetic disorder. For that reason, statutory agencies in many ... Biotin deficiency rarely occurs in healthy individuals, since the daily requirements of biotin are low, many foods contain ... People with type 2 diabetes often have low levels of biotin. Biotin may be involved in the synthesis and release of insulin. ...
Biotin deficiency is rare as it is readily available in many foods. ... Biotin (vitamin B7) plays an important role in several of the human bodys metabolic reactions and cell growth. It is partially ... Foods Containing Biotin. There are a variety of foods rich in biotin. The richest source is nuts (peanuts, filberts, almonds, ... Biotin Daily Requirements. The daily requirements of biotin vary by age and sex as follows: Infants 0-12 months: 6 micrograms ...
Lower levels and availabilty of biotin in feeds. Different batches of the same feed may vary considerably in biotin. Biotin in ... which received 1,160 µg of biotin per day during pregnancy and 2,320 µg of biotin per day during lactation. Biotin had no ... reported that plasma biotin concentration gives a good indication of biotin intake in young pigs. All cells contain some biotin ... while pelleting has little effect on biotin content of feed (McGinnis, 1988). Losses of biotin during storage can occur. Biotin ...
Biotin (Vitamin B7) helps turn food into energy. Learn how much you need, good sources, deficiency symptoms, and health effects ... Home , Making Decisions , Dietary Supplement Fact Sheets , Biotin , Biotin - Consumer Biotin. Fact Sheet for Consumers ... What is biotin and what does it do?. Biotin is a B-vitamin found in many foods. Biotin helps turn the carbohydrates, fats, and ... What foods provide biotin?. Many foods contain some biotin. You can get recommended amounts of biotin by eating a variety of ...
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Get free shipping at $35 and view promotions and reviews for 21st Century Biotin 10,000 mcg, Tablets ... 21st Century Biotin 10,000 mcg, Tablets at Walgreens. ... Biotin is part of the B-complex vitamins. It supports the ... normal metabolism of carbohydrates, proteins and fats.* Biotin also helps to support skin and hair health.* ...
  • The FNB based its determination of AIs for all populations on the amount of biotin in human milk consumed by infants and then used body weight to extrapolate AIs for other groups [ 11 ]. (nih.gov)
  • Often the amount of biotin excreted in urine and feces together exceeds total dietary intake, whereas urinary biotin excretion is usually less than intake. (dsm.com)
  • The amount of biotin you need each day depends on your age. (nih.gov)
  • Because multiple sclerosis can be a serious illness, and because the amount of biotin used in this study was very large, this treatment should be monitored by a doctor. (adventisthealthcare.com)
  • The daily amount of biotin needed is defined in several different ways. (mayoclinic.org)
  • You're probably already getting the daily recommended amount of biotin from the food you eat. (healthline.com)
  • The amount of biotin can vary from food to food, too, so be sure to read the nutritional information whenever possible. (healthline.com)
  • The fluorescent signal is directly proportional to the amount of biotin in the sample and can be detected at Ex/Em=490/520 nm. (anaspec.com)
  • In those studies, they supplement with a small amount of biotin per day, and there was a small improvement in nail thickness. (goodhousekeeping.com)
  • There is no recommended daily allowance, but an adequate amount of biotin is thought to be 30 mcg a day. (goodhousekeeping.com)
  • Taking biotin supplements might interfere with the results of many different blood lab tests. (medlineplus.gov)
  • Tell your doctor if you are taking biotin supplements, especially if you are having lab tests done as you may need to stop taking biotin before your blood test. (medlineplus.gov)
  • Biotin supplements will also effectively treat weak, splitting nails. (encyclopedia.com)
  • Biotin supplements have been studied as a treatment for a number of conditions. (webmd.com)
  • However, most people don't need biotin supplements . (webmd.com)
  • Pregnant women sometimes have low levels of biotin, so some take biotin supplements . (webmd.com)
  • If you have any medical conditions -- or are pregnant or breastfeeding -- check with a doctor before using biotin supplements. (webmd.com)
  • If you take any drugs regularly, talk to your doctor before you start using biotin supplements. (webmd.com)
  • Biotin supplements are considered harmless for just about everyone, so there's no reason not to try them for psoriasis. (healthline.com)
  • Multivitamins, including prenatal multivitamins, biotin supplements, and dietary supplements for hair, skin, and nail growth contain biotin at levels that may interfere with laboratory tests 1,2 . (medsafe.govt.nz)
  • Uses: Supplements are prescribed to treat biotin deficiency, which is caused by rare genetic disorders. (latimes.com)
  • Dose: Biotin is available by itself and in many multi-ingredient supplements. (latimes.com)
  • Precautions: Biotin supplements are generally considered safe. (latimes.com)
  • Research: There's no good evidence that biotin supplements can reduce acne, tame cowlicks or reverse hair loss or graying. (latimes.com)
  • Some people use biotin supplements to manage symptoms of psoriasis. (medicalnewstoday.com)
  • Many people believe that biotin supplements can reduce psoriasis symptoms, which can include a scaly, red rash and thinning hair. (medicalnewstoday.com)
  • That said, getting extra biotin from food or supplements is generally safe, so some people may wish to try it. (medicalnewstoday.com)
  • There is little evidence that biotin can benefit skin and hair problems, and no studies have specifically looked at the effects of biotin supplements on psoriasis. (medicalnewstoday.com)
  • People who wish to take biotin supplements should choose high-quality products from reputable suppliers. (medicalnewstoday.com)
  • Biotin interference is possible at plasma concentrations achievable by ingestion of over-the-counter supplements that may lead to delayed or missed diagnosis of myocardial injury with the Gen5 cTnT assay. (medscape.com)
  • It is important to be aware that intake of biotin supplements may lead to interference with certain laboratory tests leading to false positive or false negative results. (medscape.com)
  • The treatment for biotin deficiency is to simply start taking some biotin supplements. (newworldencyclopedia.org)
  • Biotin supplements are often recommended as a natural product to counteract the problem of hair loss in both children and adults. (newworldencyclopedia.org)
  • What kinds of biotin dietary supplements are available? (nih.gov)
  • Biotin is found in some multivitamin/multimineral supplements , in B-complex supplements , and in supplements containing only biotin. (nih.gov)
  • Dietary supplements that contain biotin are often promoted to improve the health of your hair, skin, and nails, but there is little scientific evidence to support these claims. (nih.gov)
  • More research is needed before biotin supplements can be recommended for any of these conditions. (nih.gov)
  • However, supplements that contain biotin above recommended amounts may cause false results in some lab tests, including those that measure levels of certain hormones , like thyroid hormone. (nih.gov)
  • They can tell you if the dietary supplements might interact with your medicines or laboratory tests , or if the medicines might interfere with how your body absorbs , uses, or breaks down nutrients such as biotin. (nih.gov)
  • Biotin is available in dietary supplements, individually or as an ingredient in multivitamins. (wikipedia.org)
  • Also look for biotin supplements as biotin is an essential component of the hair growth process and will sometimes be combined with B vitamins to specifically target hair growth issues. (yourdictionary.com)
  • Biotin supplements may help lower high blood pressure. (livestrong.com)
  • A healthy diet and exercise, along with certain medications and supplements such as biotin may help regulate the blood pressure and prevent the complications associated with it. (livestrong.com)
  • In case of a deficiency, your doctor may recommend biotin supplements that are available as capsules, tablets and syrups. (livestrong.com)
  • Biotin supplements are generally safe and well-tolerated when used at recommended doses. (livestrong.com)
  • Although you do not require a prescription to buy biotin supplements in the United States, you must talk to a doctor before using them to lower your blood pressure. (livestrong.com)
  • Biotin supplements have been studied as a treatment for a number of conditions, including hair loss, brittle nails, and improving blood sugars and nerve function in individuals with type 2 diabetes. (healthcastle.com)
  • However, at this time there is not enough evidence to show the effectiveness of biotin supplements for these conditions. (healthcastle.com)
  • According to the American Academy of Dermatology, getting adequate amounts of biotin through food or supplements may improve nail care and help to grow and thicken hair . (foodinsight.org)
  • The adequate intake (AI) for biotin in adults ages 19 years and older is 30 micrograms (mcg) per day from all sources, including foods and supplements. (foodinsight.org)
  • The FDA has issued a warning that too much biotin from dietary supplements has been found to interfere with certain lab tests, so it's important to consume close to the recommended amounts and use any supplements with the approval of a health care provider. (foodinsight.org)
  • Take note that a lot of people reported that their skin got better almost instantly after getting off biotin supplements. (infobarrel.com)
  • Another thing that isn't a side effect of biotin itself but of the supplement is that often with biotin supplements, there are other things inside the pills. (hubpages.com)
  • Biotin is known as the hair and nail vitamin and people taking biotin supplements are often seeking to thicken their hair and grow stronger nails. (hubpages.com)
  • At first, I was skeptical of the claims of biotin supplements because the bio-availability of biotin was said to be low. (hubpages.com)
  • But after going through many different customer reviews, I found that most people who started taking biotin supplements noticed a marked difference in the quality of both their hair and nails. (hubpages.com)
  • Biotin supplements are used to prevent or treat biotin deficiency. (mayoclinic.org)
  • Claims that biotin supplements are effective in the treatment of acne, eczema (a type of skin disorder), or hair loss have not been proven. (mayoclinic.org)
  • Biotin supplements are available without a prescription. (mayoclinic.org)
  • If you don't think you're getting enough biotin from your diet, or if you're just looking to up your dosage, supplements may be an option. (healthline.com)
  • Biotin supplements are available over the counter in capsule or tablet form. (healthline.com)
  • You can find a great selection of biotin supplements here . (healthline.com)
  • Most people can take biotin supplements without any adverse effects, but minor side effects are possible. (healthline.com)
  • Most people do not require biotin supplements, as biotin is naturally derived from foods. (reference.com)
  • Suspected Testosterone-Producing Tumor in a Patient Taking Biotin Supplements. (nih.gov)
  • Very weak evidence suggests that biotin supplements may improve thin, splitting, or brittle toe and fingernails, as well as hair. (umm.edu)
  • However, no studies have shown that biotin supplements -- given in formula or breast milk -- effectively treat cradle cap. (umm.edu)
  • There have been reports that biotin supplements improve the symptoms of peripheral neuropathy for some people who developed this condition from either diabetes or ongoing dialysis for kidney failure. (umm.edu)
  • Biotin is available in multivitamins and B-vitamin complexes, and as individual supplements. (umm.edu)
  • As with all supplements, check with a health care provider before giving biotin to a child. (umm.edu)
  • The greatest risk to taking biotin supplements seems to be that you'll pee out what your body can't use and your hair and nails will look the same. (goodhousekeeping.com)
  • Do biotin supplements really improve hair and nails? (consumerlab.com)
  • Home / Vitamins and supplements / What is biotin and what are the benefits of this vitamin? (lloydspharmacy.com)
  • Whilst proper levels of biotin should be available through a varied and balanced diet, there are biotin supplements available to those who need some dietary support. (lloydspharmacy.com)
  • Supplements are important for those who may be deficient in this vitamin, but minimal effects will be experienced in healthy individuals who absorb enough biotin through their normal diet. (lloydspharmacy.com)
  • The findings suggest that biotin supplements are effective on individuals who have hair loss relating to a biotin deficiency, however, it won't slow down the progression of hair loss in healthy individuals. (lloydspharmacy.com)
  • In general, unless you're deficient in biotin, taking supplements will not lead to any drastic improvements in your skin and nails. (lloydspharmacy.com)
  • The most reliable individual markers of biotin status, including deficiency and sufficiency, are biotinylated MCC and propionyl-CoA carboxylase in white blood cells [ 7 ]. (nih.gov)
  • What are the health benefits of biotin? (medicalnewstoday.com)
  • But before we get into the side effects and benefits of biotin, lets have a quick review. (hubpages.com)
  • Important benefits of biotin prototrophy include cost reduction during the preparation of chemically defined industrial growth media as well as a lower susceptibility of biotin-prototrophic. (asm.org)
  • Am I getting enough biotin? (nih.gov)
  • Most people get enough biotin from the foods they eat. (nih.gov)
  • What happens if I don't get enough biotin? (nih.gov)
  • Biotin deficiency is very rare, as most people are able to get enough biotin naturally from foods. (healthcastle.com)
  • If you aren't getting enough biotin, you may experience hair loss or a scaly red rash. (healthline.com)
  • Some drastic weight-reducing diets may not supply enough biotin. (wholehealthmd.com)
  • Infants who don't have enough biotin often develop this scaly scalp condition. (umm.edu)
  • Many people have trouble getting enough biotin via diet and should supplement, especially those with thinning hair or brittle nails," says Arielle Levitan, M.D., an internal medicine physician in Highland Park, IL, and co-founder of Vous Vitamin, a company that creates personalized multivitamins. (goodhousekeeping.com)
  • Apart from being a vital cofactor to several enzymes, biotin is essential in carbohydrate metabolism and the synthesis of fatty acids. (encyclopedia.com)
  • High doses of biotin are sometimes used by the allopathic medical profession to treat diabetes since it enhances sensitivity to insulin and effectively increases levels of enzymes involved in glucose metabolism. (encyclopedia.com)
  • Most importantly, we see that biotin plays key roles in fat and sugar metabolism, roles that make deficiency of biotin show up in multiple and unrelated ways. (whfoods.com)
  • Biotin is a water-soluble B-vitamin that's important for energy metabolism. (medicalnewstoday.com)
  • Biotin-containing enzymes are involved in the metabolism of several important amino acids, including leucine. (medicalnewstoday.com)
  • Biotin is a water-soluble B vitamin that is an essential cofactor for four carboxylase enzymes, each of which catalyzes an essential step in intermediary metabolism. (chiro.org)
  • 1 ] Besides genetic inborn errors of metabolism, biotin deficiency can occur during extended parenteral nutrition, pregnancy, or long-term anticonvulsant therapy. (chiro.org)
  • Biotin deficiency in humans is rare and generally associated with extended parenteral nutrition, consumption of large quantities of raw egg whites, severe malnutrition, or inborn errors of metabolism (e.g., biotinidase deficiency, multiple carboxylase deficiency). (chiro.org)
  • Animal studies suggest biotin may also help improve glucose metabolism in people with Type 2 diabetes, but much more research is needed to confirm its effects. (latimes.com)
  • Biotin or B7, one of the B vitamins, is an essential nutrient that plays key roles in the metabolism of glucose, amino acids, and fatty acids. (medscape.com)
  • Patients affected by certain genetic defects affecting biotin metabolism present with a clinical picture of biotin deficiency. (medscape.com)
  • Through this carboxyl group, biotin is linked covalently to the β-amino group of lysine in 5 carboxylases that play critical roles in intermediary metabolism. (medscape.com)
  • Biotin functions as a coenzyme in carboxylation reactions involving lipid, glucose and amino acid metabolism. (medscape.com)
  • Biotin is important in a number of essential metabolic reactions in humans, including catalyzing the synthesis of fatty acids , metabolism of the amino acid leucine , and gluconeogenesis (generation of glucose from non- sugar carbon substrates like pyruvate , glycerol , and amino acids). (newworldencyclopedia.org)
  • The few animal studies of biotin metabolism revealed that biotin is absorbed as the intact molecule in the first third to half of the small intestine (Bonjour, 1984). (dsm.com)
  • Investigations into biotin metabolism in animals are difficult to interpret, as biotin-producing microorganisms exist in the intestinal tract distal to the cecum. (dsm.com)
  • Biotin deficiency can be caused by inadequate dietary intake (rare) or inheritance of one or more inborn genetic disorders that affect biotin metabolism. (wikipedia.org)
  • Biotin functions in fatty acid metabolism and the production of glucose. (livestrong.com)
  • A study published in the January 2011 issue of the journal 'Molecular Genetics and Metabolism' found that biotin deficiency impairs glucose and cholesterol regulation. (livestrong.com)
  • Biotin is a water-soluble B vitamin that is involved in the metabolism of protein, fats, and carbohydrates. (wegmans.com)
  • Humans can't store biotin, so eating biotin-rich foods daily is important for getting the adequate amounts needed for gene regulation and metabolism. (foodinsight.org)
  • Two hours after an intraventricular injection, [ 3 H]biotin was cleared from the CSF more rapidly than mannitol and minimal metabolism of the [ 3 H]biotin had occurred in brain. (springer.com)
  • These results show that biotin enters CSF and brain by saturable transport systems that do not depend on metabolism of the biotin. (springer.com)
  • Metabolism of carbonyl-labeled 14 C-biotin in the rat. (springer.com)
  • Biotin, a water-soluble B vitamin, acts as a coenzyme in the metabolism of protein, fats, and carbohydrates. (adventisthealthcare.com)
  • High doses of biotin have been suggested to reverse some of the negative effects of chronic low insulin levels on glucose metabolism. (adventisthealthcare.com)
  • For example, biotin is one of several B vitamins that supports a healthy metabolism. (healthline.com)
  • Biotin may also be referred to as vitamin H. This supplement promotes the health of nerves, the digestive tract, metabolism, skin and cells. (reference.com)
  • Biotin is one of the B vitamins necessary for the formation of glucose and fatty acids, and for the metabolism of amino acids and carbohydrates. (wholehealthmd.com)
  • It is suggested that in diabetes may exist a deficiency, inactivity or unavailability of Biotin, resulting in disordered activity of biotin-dependent enzyme, pyruvate carboxylase, leading to accumulation of pyruvate and/or depletion of aspartate, both of which play a significant role in nervous system metabolism. (nih.gov)
  • Biotin (vitamin B7) is a water-soluble vitamin and essential cofactor for the metabolism of fatty acids, glucose, and amino acids. (nih.gov)
  • Biotin is a coenzyme and vitamin B or vitamin H. It's not just for hair growth, as it's sometimes used for diabetes and supports the health of skin, nerves, digestive tract, metabolism and cells. (naturallycurly.com)
  • Consistent with the important roles of HLCS in biotin metabolism, no living HLCS null individual has ever been reported, suggesting embryonic lethality. (pubmedcentralcanada.ca)
  • Biotin deficiency causes low activity of MCC, thereby shunting metabolites from leucine metabolism to alternative pathways. (pubmedcentralcanada.ca)
  • Biotin is critical for the metabolism of fatty acids and carbs, but that's not what people are using it for. (goodhousekeeping.com)
  • Biotin serves an array of functions in the human body, but is particularly important for metabolism of fats, carbohydrates, and amino acids. (fsu.edu)
  • Dietary avidin, a glycoprotein in raw egg whites, binds tightly to dietary biotin and prevents biotin's absorption in the gastrointestinal tract [ 13 , 14 ]. (nih.gov)
  • Certain individuals are at risk for biotin deficiency, including infants fed biotin-deficient formula or with inherited deficiency disorders, patients who are fed intravenously, and anyone who habitually eats a lot of raw egg whites, because they contain a protein called avidin, which prevents the absorption of biotin. (encyclopedia.com)
  • Three primary methods of biotin analysis involve (1) bacterial growth studies, (2) studies in which biotin binds to a protein called avidin (or sometimes streptavidin), and (3) dye-based studies using a chemical called 4'-hydroxyazobenzene-2-carboxylic acid. (whfoods.com)
  • Raw egg whites contain a protein called avidin, which binds to biotin and prevents its absorption. (medicalnewstoday.com)
  • It was later discovered that uncooked egg whites contain a glycoprotein, avidin, that binds to biotin and prevents its absorption, whether biotin is from the diet or from intestinal bacterial synthesis. (chiro.org)
  • Avidin, a protein found in egg whites, binds strongly to biotin, impairing the absorption of the vitamin, leading to severe biotin deficiency in those who consume excessive amounts of raw eggs. (medscape.com)
  • The biochemical basis for egg-white injury syndrome was quickly elucidated when raw egg whites were found to contain the glycoprotein avidin, which has a remarkable affinity for biotin. (medscape.com)
  • as a result, biotin is not liberated from food, and the biotin-avidin complex is lost in the feces. (medscape.com)
  • The final step in solving the mystery of egg-white injury syndrome was the demonstration that the syndrome could be prevented by heating the egg whites, a process that denatures avidin and destroys its affinity for biotin. (medscape.com)
  • The ureido ring is involved in the high affinity binding of biotin to avidin, a glycoprotein found in egg-white. (medscape.com)
  • Egg-whites contain high levels of avidin, a protein that binds biotin strongly. (newworldencyclopedia.org)
  • Once a biotin-avidin complex forms, the bond is essentially irreversible. (newworldencyclopedia.org)
  • The biotin-avidin complex is not broken down nor liberated during digestion, and the biotin-avidin complex is lost in the feces. (newworldencyclopedia.org)
  • Uncooked eggs contain a protein called avidin that binds with biotin and prevents its absorption. (foodinsight.org)
  • Avidin is denatured by the cooking process, so eating cooked eggs does not put a person at risk for biotin deficiency. (foodinsight.org)
  • Avidin biotin-binding protein immobilized onto beaded agarose resin for affinity purification methods involving biotinylated proteins and ligands. (fishersci.com)
  • Avidin or streptavidin form strong complexes with biotin providing high signal amplification due to the large binding capacity of biotin (up to four molecules of avidin or streptavidin). (abcam.com)
  • Biotin forms large complexes with avidin or streptavidin for signal amplification. (abcam.com)
  • Biotin-labeled oligonucleotides have become extremely popular in DNA capture and detection applications, due to their very high sensitivity and strong, specific binding affinity with avidin and streptavidin proteins. (sigmaaldrich.com)
  • First, avidin (Reagent A tagged with a quencher dye) is briefly incubated with biotin samples/standards. (anaspec.com)
  • The HABA Biotin Quantitation assay employs HABA (4'-hydroxyazobenzene-2-carboxylic acid), a reagent that shows dramatic spectral changes when bound to avidin. (anaspec.com)
  • Biotin easily displaces HABA from the HABA/Avidin complex, resulting in a decrease of absorption at 500 nm. (anaspec.com)
  • Raw egg whites contain a protein called Avidin that interferes with the body's absorption of biotin. (umm.edu)
  • the biotin-binding protein avidin in raw egg white causes a substantial decrease in the bioavailability of biotin ( 1 ). (pubmedcentralcanada.ca)
  • So, the problem could be biotin-avidin problem. (bio.net)
  • Eating an excessive amount of raw egg whites, which contain the biotin antagonist avidin, can also induce the condition. (fsu.edu)
  • it has a better avidin-binding affinity than biotin. (anaspec.com)
  • Biotin, SE (d-Biotin-N-hydroxysuccinimide ester) contains a five-carbon spacer arm that reduces steric hindrance associated with binding four biotinylated molecules per one avidin and results in enhanced detection sensitivity. (anaspec.com)
  • Supplementation ranges from 100 - 600 mcg per day, and can be obtained in the form of brewer's yeast, which contains biotin as part of the B complex, or as an individual biotin supplement. (encyclopedia.com)
  • Urinary excretion of biotin and its metabolites is similar for intravenous dosing and oral supplementation at high doses, suggesting 100-percent bioavailability of orally administered biotin. (chiro.org)
  • 5 ] In healthy adults and children not receiving biotin supplementation, the kidneys clear biotin and creatinine in a ratio of approximately 0.4.1 Specific systems for transport of biotin from mother to fetus [ 6-8 ] and from mother to infant via breastmilk, [ 9, 10 ] have been described. (chiro.org)
  • 16 ] One study found 50 percent of pregnant women had increased urinary excretion of 3-hydroxyisovaleric acid (a reflection of biotin deficiency) that was reversed by supplementation of 300 mcg biotin for 14 days. (chiro.org)
  • However, no strong scientific evidence suggests that biotin supplementation effectively treats psoriasis or other skin problems in otherwise healthy people. (medicalnewstoday.com)
  • Similarly, a 2005 case report of a single infant with low biotin levels indicated that daily supplementation with 1 mg of biotin improved both dermatitis symptoms and hair growth. (medicalnewstoday.com)
  • cTn levels were measured in (1) plasma from healthy volunteers on 10-mg daily biotin supplementation mixed with a plasma with known elevated troponin, (2) plasmas with known elevated cTn after mixing in reagent biotin to simulate supplementation, and (3) biotin-spiked plasma specimens pretreated with streptavidin-agarose beads. (medscape.com)
  • Supplementation with biotin leads to clinical improvement in most cases. (medscape.com)
  • Selenium-based shampoos, topical applications of flax oil and/or olive oil, and biotin supplementation are among the therapies recommended for seborrheic dermatitis. (yourdictionary.com)
  • However, no significant change in glucose, insulin, triglycerides or cholesterol occurred from biotin supplementation in either group. (livestrong.com)
  • Researchers concluded that biotin and chromium picolinate supplementation shows potential for managing blood sugar and lipids in diabetic patients. (livestrong.com)
  • However, people who consume a large number of raw egg whites over long periods of time and those who have been on prolonged intravenous feeding (paranteral/TPN) without biotin supplementation are at risk for a deficiency. (healthcastle.com)
  • However, there is a lack of sufficient evidence for biotin supplementation in healthy individuals. (foodinsight.org)
  • In a preliminary study, supplementation with biotin was associated with an improvement in neurological function in patients with chronic progressive multiple sclerosis. (adventisthealthcare.com)
  • In a preliminary study, supplementation with large amounts of biotin (100 to 300 mg per day) for an average of 9 months was associated with an improvement in neurological function in a majority of patients with chronic progressive multiple sclerosis. (adventisthealthcare.com)
  • This is supported by field experiences but very occasionally a herd is investigated for lameness problems that appear to be improved with biotin supplementation of the diet. (thepigsite.com)
  • Recently, there has been a surge in biotin supplementation mainly for beauty reasons, including: stronger nails and healthier skin and hair, resulting in the biotin craze on Instagram. (randox.com)
  • Whilst biotin supplementation is beneficial for numerous health conditions, including: multiple sclerosis (MS), diabetes, elevated cholesterol, and metabolic dysfunction, the increasing use of biotin by patients has created a problem with in vitro diagnostic testing. (randox.com)
  • With numerous manufacturers using biotin-streptavidin technology to develop in vitro diagnostic tests, combined with the rise in biotin supplementation use, the FDA (food and drug administration) issued an alert regarding the potential for erroneous results triggered by high levels of biotin in patient samples, at the end of 2017. (randox.com)
  • Taking biotin can help treat low blood levels of biotin. (medlineplus.gov)
  • It can also prevent blood levels of biotin from becoming too low. (medlineplus.gov)
  • Low blood levels of biotin can cause thinning of the hair and rash around the eyes, nose, and mouth. (medlineplus.gov)
  • Cigarette smoking might also cause low blood levels of biotin. (medlineplus.gov)
  • In their book The Yeast Syndrome , John Parks Trowbridge and Morton Walker describe how adequate levels of biotin can prevent Candida albicans from developing from its yeast-like state into fungal form, in which it sends out mycelium that further invade body organs. (encyclopedia.com)
  • Women who are pregnant or breastfeeding may need higher levels of biotin. (healthline.com)
  • For most individuals, sufficient levels of biotin can be obtained through diet alone. (lorealparisusa.com)
  • Proper levels of biotin can be easily maintained through a varied and balanced diet. (lloydspharmacy.com)
  • Pregnant and breastfeeding women - despite normal biotin consumption, pregnant and breastfeeding women tend to have lower levels of biotin. (lloydspharmacy.com)
  • The FDA confirmed that a patient, who was consuming high levels of biotin, died when a troponin tested was skewed and failed to show that the patient was having a heart attack. (randox.com)
  • In the patient sample containing high levels of biotin, the biotin inhibits streptavidin's ability to capture the analyte-antibody complex, generating falsely lowered results. (randox.com)
  • Early research suggests that taking biotin by mouth for up to a year might increase the thickness of fingernails and toenails in people with brittle nails. (medlineplus.gov)
  • Seborrheic dermatitis , or Leiner's disease, which is a non-itchy, red scaling rash affecting infants during the first three months of life, is also treated with biotin and other B complex vitamins. (encyclopedia.com)
  • Biotin is one of the B-vitamins, also known as vitamin B7. (medicalnewstoday.com)
  • Pantothenic acid (B5) and biotin (B7) are types of B vitamins. (medlineplus.gov)
  • Biotin is available in supplement form alone, in combination with other B vitamins , or as part of a multivitamin supplement. (medicalnewstoday.com)
  • Like other B vitamins, biotin helps the body convert certain nutrients, proteins and fats into energy. (selfgrowth.com)
  • Biotin, vitamin B-7, is a member of the water-soluble family of B complex vitamins. (livestrong.com)
  • Another study in the January 2003 issue of the "Journal of Human Hypertension" reveals that reduced intake of B vitamins such as biotin and folic acid increased the risk of hypertension South African children. (livestrong.com)
  • Biotin is one of 8 B vitamins. (healthcastle.com)
  • Originally called vitamin H, biotin is now classified as one of the B vitamins (B7) and has gained commercial popularity for its proposed benefits for healthier hair and nails. (foodinsight.org)
  • They have increased needs and most prenatal vitamins don't contain biotin. (foodinsight.org)
  • The vitamins information pages - Biotin. (infobarrel.com)
  • Biotin is often classified with the family of B Vitamins, and for the purposes of this article, the differences aren't important. (hubpages.com)
  • 3a Vitamins, pro-vitamins and substances having similar effect: E300 Vitamin C 5000 mg, 5000 mg 3a314 niacin, pantothenic acid 4000 mg, 1500 mg folate 3a316, 3a890 choline (chloride) 1250 mg, 800 mg biotin, inositol 750 mg E672 vitamin A 500,000 IU. (viovet.co.uk)
  • Vitamin H, more commonly known as biotin, is part of the B complex group of vitamins. (umm.edu)
  • Biotin is a member of the B-complex family of vitamins. (vitamedica.com)
  • OGX's Biotin & Collagen Extra Volume Extra Strength Conditioner is a volume-creating powerhouse with an extra helping of vitamins and proteins to pump up flat strands. (ulta.com)
  • Some preliminary evidence suggests that biotin might help strengthen brittle nails. (webmd.com)
  • Biotin may benefit brittle nails ( 7 ). (medicalnewstoday.com)
  • In one study, 8 people with brittle nails were given 2.5 mg of biotin per day for 6 to 15 months. (medicalnewstoday.com)
  • Another study of 35 people with brittle nails found 2.5 mg of biotin per day for 1.5 to 7 months improved symptoms in 67% of participants ( 9 ). (medicalnewstoday.com)
  • Biotin has been shown to stop baldness in limited cases, and to help smooth brittle fingernails. (healthline.com)
  • The vitamin ingredient Biotin improves the quality of keratin structures and hence has a positive effect on fine and brittle hair and nails. (dsm.com)
  • Biotin is sometimes recommended to combat brittle hair and nails. (ehow.co.uk)
  • In a few small studies , some people with thin and brittle nails who took high doses of biotin had harder nails. (nih.gov)
  • As a result, Swiss researchers investigated the use of biotin in strengthening brittle fingernails in humans, despite the fact that it remains unclear exactly how biotin affects nail structure. (adventisthealthcare.com)
  • In an uncontrolled study of people who had been taking biotin for brittle nails in America, 63% showed improvement from taking biotin. (adventisthealthcare.com)
  • Although the amount of research on the subject is quite limited and positive effects do not appear in all people, those people having brittle nails may want to consider a trial period of at least several months, using 2.5 mg per day of biotin. (adventisthealthcare.com)
  • If you're biotin deficient, you may have hair loss or brittle nails. (chiroeco.com)
  • The thinking goes a little something like this: Because people who are deficient in biotin have certain symptoms - including facial rashes, pink eye, and yes, thinning hair and brittle nails - upping your biotin intake may help. (goodhousekeeping.com)
  • If you have dermatitis, dry skin, thinning hair, loss of hair color or brittle nails, you may be short in biotin. (vitamedica.com)
  • Oral administration of large doses of biotin increases serum concentrations of biotin and its metabolites [ 1 , 9 ]. (nih.gov)
  • Most multivitamins contain low doses of biotin, which are unlikely to interfere with blood tests. (medlineplus.gov)
  • Oral biotin is completely absorbed, even at high, pharmacological doses. (chiro.org)
  • Biotin at pharmacological doses (3.1 µM/day) to healthy adults resulted in decreased synthesis of cytokines (interleukin-1β and interleukin- 2) and decreased proliferation of peripheral blood mononuclear cells (PBMC) a combination of T-cells, B-cells, and granulocytes. (chiro.org)
  • Biotin is generally safe to take, even in high doses. (medicalnewstoday.com)
  • One small-scale 2015 study reported that high doses of biotin may slow the effects and progression of multiple sclerosis , a disease of the central nervous system . (medicalnewstoday.com)
  • Over-the-counter (OTC) biotin (vitamin B 7 ) sales have increased due to perceived health and cosmetic benefits at doses of 5 to 10 mg/d, which are more than 150 times the Adequate Intake recommendation. (medscape.com)
  • [ 3 ] Very high doses of biotin up to 300 mg/d are currently under investigation as a therapy for multiple sclerosis. (medscape.com)
  • Early detection and treatment with pharmacologic doses of biotin are important to prevent the development of irreversible complications. (medscape.com)
  • Doctors have also reported that in a few cases, high doses of biotin have improved a rare hair disorder in children and skin rash in infants. (nih.gov)
  • A study published in the December 2006 issue of the journal 'Diabetes Technology and Therapeutics' found that doses of 2 milligrams per day of biotin and 600 micrograms per day of chromium picolinate for four weeks significantly improved results of glucose tolerance tests for 43 diabetic study volunteers. (livestrong.com)
  • In a placebo-controlled trial, people with type 1 diabetes treated with biotin at doses of about 2-4 mg per day, depending on body weight, had improvements in blood glucose regulation and blood lipid levels after three months. (adventisthealthcare.com)
  • No serious side effects are associated with recommended doses of biotin. (wholehealthmd.com)
  • No problems are expected in older persons taking recommended doses of biotin. (wholehealthmd.com)
  • No problems are expected with the intake of recommended doses of biotin during pregnancy. (wholehealthmd.com)
  • Biotin in high doses was given for 1-2 years to three diabetic patients suffering from severe diabetic peripheral neuropathy. (nih.gov)
  • Nevertheless, biotin has not been associated with side effects, even in high doses, and is considered to be nontoxic. (umm.edu)
  • Some mutations respond well to pharmacological doses of biotin if diagnosed early. (pubmedcentralcanada.ca)
  • Afflicted patients are treated with pharmacological doses of biotin to compensate for the urinary loss of biotin. (pubmedcentralcanada.ca)
  • Likewise, biotin deficiency might be encountered in smokers, users of certain anticonvulsants, and after consumption of pharmacological doses of lipoic acid. (pubmedcentralcanada.ca)
  • Most biotin in foods is bound to protein, although some dietary biotin is in the free form [ 1 , 3 , 4 , 6 ]. (nih.gov)
  • Gastrointestinal proteases and peptidases break down the protein-bound forms of ingested biotin into biocytin and biotin-oligopeptides, which undergo further processing by biotinidase, an enzyme, in the intestinal lumen to release free biotin [ 6 ]. (nih.gov)
  • Biotin is a water-soluble B vitamin that helps you transform fat, protein and carbohydrates in your food to energy needed by the body. (eatingwell.com)
  • Biotin was originally recognized when rats fed protein derived from egg whites developed severe dermatitis, hair loss, and neuromuscular dysfunction. (chiro.org)
  • On the other hand, biotin reveals the importance of balance in one's diet, as excessive consumption of raw egg-whites over a long period of time can result in biotin deficiency, as a protein in the egg-whites binds with biotin and results in its removal. (newworldencyclopedia.org)
  • Naturally occurring biotin is found partly in the free state (fruit, milk, vegetables) and partly in a form bound to protein in animal tissues, plant seeds and yeast. (dsm.com)
  • Biotin is essential for the formation of fatty acids and for gluconeogenesis, the breakdown of protein for energy during starvation. (healthcastle.com)
  • Animal-based protein sources like beef liver, chicken liver, salmon and eggs have a high biotin content. (foodinsight.org)
  • Although dairy products are a source of animal protein, they contain only small amounts of biotin. (foodinsight.org)
  • In enzymology, a biotin carboxylase (EC 6.3.4.14) is an enzyme that catalyzes the chemical reaction ATP + biotin-carboxyl-carrier protein + CO2 ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + carboxybiotin-carboxyl-carrier protein The 3 substrates of this enzyme are ATP, biotin-carboxyl-carrier protein, and CO2, whereas its 3 products are ADP, phosphate, and carboxybiotin-carboxyl-carrier protein. (wikipedia.org)
  • The systematic name of this enzyme class is biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming). (wikipedia.org)
  • Bind biotinylated proteins and other ligands with a wide selection of high-quality agarose and acrylamide beads and columns of recombinant streptavidin biotin-binding protein. (fishersci.com)
  • Biotin is covalently attached to biotin-dependent carboxylase by biotin protein ligase, also known as holocarboxylase synthase in mammals, to form an active holocarboxylase. (genome.jp)
  • For example, in one 2015 study , women with thinning hair were given an oral marine protein supplement (MPS) containing biotin or a placebo pill twice per day for 90 days. (healthline.com)
  • This could lead to a difference in the mode of binding of (+)-epi-biotin to streptavidin, a natural protein receptor for (+)-biotin. (rcsb.org)
  • The Escherichia coli biotin holoenzyme synthetase, BirA, catalyzes transfer of biotin to the epsilon amino group of a specific lysine residue of the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase. (nih.gov)
  • We conclude that the 14-mer peptide efficiently mimics the biotin acceptor function of the much larger protein domain normally recognized by BirA. (nih.gov)
  • The SensoLyte® Biotin Assay Kits provide a convenient assay for estimating the molar ratio of biotin to protein in biotin-protein conjugates or for quantifying biotin concentration in a solution. (anaspec.com)
  • Your body needs biotin to metabolize carbohydrates, fats and amino acids, the building blocks of protein. (umm.edu)
  • They contain biotin carboxylase (BC), carboxyltransferase (CT), and biotin-carboxyl carrier protein components. (springer.com)
  • This shampoo is fortified with biotin, saw palmetto, and wheat protein to help control hair loss while the B-Complex helps healing damaged tresses. (naturallycurly.com)
  • Soy proteins and panthenol to strengthen, jojoba oil will moisturize, amino acids fortify, biotin, and folic acid help to grow hair while the vegetable protein conditions and reduces split ends. (naturallycurly.com)
  • A hair thickening shampoo that is rich with biotin, keratin, protein, and cysteine nourishes your hair and scalp. (naturallycurly.com)
  • The foreign protein is recognized and biotinated by biotin holoenzyme synthetase of E. coli. (pnas.org)
  • The succinimidyl ester (SE) reactive form of biotin reacts with the amine group on the protein and forms stable carboxamide bonds, which is identical to natural peptide bonds. (anaspec.com)
  • Biotin-protein conjugates are very stable and can withstand the conditions of immunofluorescent staining, fluorescence in situ hybridization, flow cytometry and other biological applications without hydrolysis. (anaspec.com)
  • The kit has all essential components for performing the conjugation reaction and for purifying the biotin-protein conjugates. (anaspec.com)
  • Among the World's Healthiest Foods, you will also find 5 additional very good sources of biotin and 13 good sources of this vitamin. (whfoods.com)
  • Nuts, root vegetables, and eggs are among our best sources of biotin. (whfoods.com)
  • Biotin may be labelled as Vitamin B7 or Vitamin H in these products. (medsafe.govt.nz)
  • Biotin (vitamin B7) plays an important role in several of the human body's metabolic reactions and cell growth. (ehow.co.uk)
  • Vitamin B7 Biotin infuses nutrients into every strand of hair, while collagen & keratin make it thick, full, and beautiful. (wegmans.com)
  • Taking vitamin B7 (biotin) pills might not influence your skin at all, it really depends on one's body. (infobarrel.com)
  • Foods rich in Biotin (vitamin B7). (shutterstock.com)
  • Biotin (vitamin B7). (shutterstock.com)
  • Chemical formula of Vitamin B7 (Biotin) with black pen. (shutterstock.com)
  • Biotin (vitamin H, vitamin B7). (shutterstock.com)
  • Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. (genome.jp)
  • Biotin, also known as vitamin B7 and vitamin H, occurs naturally in your body. (chiroeco.com)
  • Biotin , also known as Vitamin B7, is a water-soluble nutrient found in foods. (goodhousekeeping.com)
  • Biotin is often called vitamin H, Vitamin B7, it is a water-soluable vitamin classified as B complexs vitamin. (beauty-cosmetic-guide.com)
  • Biotin, also known as Vitamin B7, is a water-soluble coenzyme that is part of the complex B Vitamin family. (lorealparisusa.com)
  • Biotin is a water-soluble vitamin (vitamin B7) found naturally in a variety of foods. (lloydspharmacy.com)
  • Foods such as eggs, milk, or bananas contain small amounts of biotin. (medlineplus.gov)
  • While it can be found naturally in foods like salmon, avocado and cauliflower, you'll only absorb small amounts of biotin this way. (selfgrowth.com)
  • A harmonious relationship with symbiotic bacteria in the intestine of humans helps in preventing biotin deficiency as these bacteria synthesize small amounts of biotin. (newworldencyclopedia.org)
  • Deficiency of biotin, a water-soluble B vitamin, may occur from nutritional causes, but more commonly results from deficiencies of enzymes involved in biotin homeostasis (e.g. biotinidase deficiency ). (medscape.com)
  • People with diagnosed biotinidase deficiency, a rare genetic disorder in which the body cannot process biotin. (foodinsight.org)
  • Biotin and biotinidase deficiency. (lorealparisusa.com)
  • Streptavidin pretreatment blocked biotin interference in cTn assays. (medscape.com)
  • For cTn assays relying on this format, excess biotin could bind the streptavidin, thereby blocking binding of the cTn-antibody complexes. (medscape.com)
  • the low-cost alternative to streptavidin biotin-binding supports. (fishersci.com)
  • Diffraction data were collected to a maximum of 0.85 Angstrom resolution for structural analysis of the complex of streptavidin with a sample of (+)-epi-biotin and refinement was carried out at both 1.0 and 0.85 Angstrom resolution. (rcsb.org)
  • Complexes of biotin-antibody-analyte are captured to a streptavidin-coated well through strong interactions between biotin and streptavidin. (nih.gov)
  • As 70% of all clinical decisions are based on results from in vitro diagnostic tests, it is vital that laboratories are selecting in vitro diagnostic tests that do not adopt the biotin-streptavidin technology to ensure accurate patient testing. (randox.com)
  • Randox do not utilise the biotin-streptavidin technology in the development of the Biochip Array Technology (BAT). (randox.com)
  • This technology, free from biotin-streptavidin, uses capture antibodies bound to a solid substrate (biochip surface) as opposed to biotinylated antibodies used by other manufacturers. (randox.com)
  • In humans, biotin is required as a prosthetic group for four major carboxylase enzymes involved in several critical metabolic pathways, including gluconeogenesis, fatty acid synthesis, and amino acid catabolism. (chiro.org)
  • Biotin is essential in the human diet because it helps break down fats, glucose, and the amino acids that make up proteins. (medicalnewstoday.com)
  • Naturally occurring biotin is often bound to the amino acid lysine. (dsm.com)
  • Biotin has a wide variety of very necessary functions inside the human body, including aiding in the production of essential fatty acids, cell growth, and metabolizing things like fats and amino acids. (hubpages.com)
  • Biotin converts glucose from carbohydrates into energy for the body and aids amino acids in carrying out normal bodily functions. (healthline.com)
  • The amino acids, DHT inhibitors, and biotin make this an ideal shampoo for promoting hair growth. (naturallycurly.com)
  • When looking for the right shampoo or natural conditioner for women, consider swapping your conventional hair care products for an all-natural brand that includes biotin. (selfgrowth.com)
  • Biotin shampoo and conditioner will work wonders for your hair, and is known for combatting hair loss. (selfgrowth.com)
  • Of course, you'll want to make sure the product you use containing biotin is all natural, as biotin will be ineffective when combined with synthetic chemicals, commonly found in conventional bottles of shampoo. (selfgrowth.com)
  • Biotin shampoo will help rejuvenate hair and offers a deep cleanse to the scalp, removing dirt and oil build up, allowing the scalp to breathe better This will increase your hair's elasticity and strength, which ultimately creates healthier hair right from the root. (selfgrowth.com)
  • With this in mind, using both biotin shampoo and conditioner regularly will help promote new hair growth, making it essential for anyone suffering from hair loss. (selfgrowth.com)
  • Biotin in natural shampoo and conditioner for women, is the ingredient you'll want for the best results. (selfgrowth.com)
  • Biotin is most notably added to shampoo. (hubpages.com)
  • The worst side effect I came across was a person complaining that biotin shampoo dried out her hair excessively. (hubpages.com)
  • As far as biotin shampoo is concerned, the question needs to be asked, can the hair and the scalp actually absorb and utilize the biotin? (hubpages.com)
  • Person's who have bought a biotin shampoo and seen good results from it have more than likely benefited from some other chemical combination within the shampoo that's known to stimulate hair growth. (hubpages.com)
  • Jason Biotin Shampoo - Restora. (ethicalsuperstore.com)
  • The Restorative Biotin Shampoo from Jason is paraben, SLS and phthalate free to naturally clean and strengthen hair. (ethicalsuperstore.com)
  • The Jason Biotin Shampoo - Restorative - 500ml product ethics are indicated below. (ethicalsuperstore.com)
  • There are currently no questions to display about Jason Biotin Shampoo - Restorative - 500ml. (ethicalsuperstore.com)
  • For best results use with Jason Biotin Shampoo. (ethicalsuperstore.com)
  • The biotin in this thick shampoo is coupled with collagen for double benefit. (naturallycurly.com)
  • This is the perfect shampoo for removing excess sebum and infusing biotin into your scalp and pores. (naturallycurly.com)
  • Limp, thinning hair gets a boost with this scalp stimulating Biotin B-Complex therapy shampoo. (naturallycurly.com)
  • Here is an herbally infused ayurvedic shampoo that's enhanced with biotin and aloe vera. (naturallycurly.com)
  • A stimulant for weak hair, this biotin strengthening shampoo has seven nourishing, healthy hair nutrients that will make your hair vibrant and feel stronger. (naturallycurly.com)
  • The Biotin Repair Shampoo strengthens and restores the lost moisture back to your tresses and give your fine, thinning hair back its fullness. (naturallycurly.com)
  • Use silica and biotin augmented shampoo which prevents hair loss. (beauty-cosmetic-guide.com)
  • Because biotin is water soluble, excessive intake of biotin-containing foods has not shown to be toxic to humans. (healthcastle.com)
  • The adequate intake of biotin depends on the age of the person taking the supplement and varies from 5 to 35 micrograms per day, reports WebMD. (reference.com)
  • The recommended daily intake of biotin for adults is 30 µg/d. (nih.gov)
  • The human requirement of biotin is not known and, therefore, recommendations for adequate intake (AI) are based on the average intake of biotin in an apparently healthy population ( 2 , 3 ). (pubmedcentralcanada.ca)
  • In this article, we look at the effects of biotin on psoriasis, and we list some other ways to treat this chronic skin condition. (medicalnewstoday.com)
  • What are some effects of biotin on health? (nih.gov)
  • In instances such as this, the Academy sets adequate intakes (AIs) with the understanding that at some later date, when the physiological effects of biotin are better understood, AIs will be replaced by more exact information. (wikipedia.org)
  • Further research on the effects of biotin on blood sugar maintenance and diabetes in humans is warranted. (livestrong.com)
  • What about side effects of biotin cosmetics? (hubpages.com)
  • What are some other side effects of Biotin Sublingual Tablets? (drugs.com)
  • Research on the effects of biotin on hair growth is sparse. (healthline.com)
  • 2 ] Percutaneous absorption of biotin from a biotin-containing ointment has been demonstrated in healthy subjects and patients with atopic dermatitis. (chiro.org)
  • There is also absorption of biotin from the hind gut of the pig, with disappearance of 50% and 61% of infused biotin between the cecum and feces that was accompanied by a more than a four-fold increase of plasma biotin concentration and a more than six-fold increase of urinary biotin excretion (Barth et al. (dsm.com)
  • Individuals living with alcoholism - long term daily consumption of alcohol reduces the absorption of biotin, leaving individuals vulnerable to low levels of this vitamin. (lloydspharmacy.com)
  • The free biotin is then absorbed in the small intestine, and most biotin is stored in the liver [ 1 , 3 , 6 ]. (nih.gov)
  • 4 ] After transport from the intestines to the peripheral circulation, biotin is taken up by the liver and eventually crosses the blood-brain barrier into the central nervous system via a saturable system. (chiro.org)
  • Balanced diets normally provide all the biotin people need -- the vitamin is particularly plentiful in liver, egg yolks, yeast, salmon, carrots and peanuts. (latimes.com)
  • All cells contain some biotin, with largest quantities in liver and kidney. (dsm.com)
  • Depletion of biotin from brain and liver in biotin deficiency. (springer.com)
  • A biotin deficiency is somewhat rare, and is more likely to occur if you are pregnant, drink alcohol, smoke, have Crohn's or liver disease, or eat a lot of processed foods. (chiroeco.com)
  • You can get your biggest hit of biotin in beef liver (not exactly a family favorite). (goodhousekeeping.com)
  • Eat food eggs yolk and liver which contains lot of biotin to prevent hair loss and to maintain the health. (beauty-cosmetic-guide.com)
  • Healthy adults usually get 30 to 100 micrograms of biotin a day from their diets. (latimes.com)
  • A study from 1985 reported that infants with rash, dermatitis, or alopecia experienced improvements in symptoms after taking 100 micrograms (mcg) to 10 milligrams (mg) of biotin per day. (medicalnewstoday.com)
  • In order to reap the benefits that biotin has to offer, you should get between 30 and 100 micrograms (mcg) per day. (selfgrowth.com)
  • The supplement contains 3000 micrograms of biotin , 100 percent of your daily intake of vitamin A, 200 percent of your daily intake of vitamin C, 25 percent of your daily intake of vitamin D, and 50 percent of your daily intake of vitamin E. (yourdictionary.com)
  • A and pregnant woman and healthy person should consume 300 micrograms of Biotin in routine diet. (beauty-cosmetic-guide.com)
  • Breastfeeding mothers need about 350 micrograms of Biotin. (beauty-cosmetic-guide.com)
  • Biotin is LIKELY SAFE when used in recommended amounts during pregnancy and breast-feeding. (medlineplus.gov)
  • When PABA and biotin are taken together in adequate amounts they can restore hair color. (encyclopedia.com)
  • Soybeans, mushrooms, and pumpkin and sunflower seeds are examples of foods with substantial amounts of biotin that are not quantified in the databases we use to determine the biotin concentrations in foods. (whfoods.com)
  • Thus far, no ill effects have been reported by humans eating large amounts of biotin. (eatingwell.com)
  • Biotin deficiency rarely occurs in healthy individuals, since the daily requirements of biotin are low, many foods contain adequate amounts, intestinal bacteria synthesize small amounts, and the body effectively scavenges and recycles biotin from bodily waste. (newworldencyclopedia.org)
  • Consumption of large amounts as a dietary supplement results in absorption, followed by excretion into urine as biotin. (wikipedia.org)
  • When consumed as a biotin dietary supplement, absorption is nonsaturable, meaning that even very high amounts are absorbed effectively. (wikipedia.org)
  • Although biotin is found in varying amounts in a wide range of natural food sources in the diet, few are particularly rich sources. (healthcastle.com)
  • While most people get sufficient amounts of it in their diet, biotin may be prescribed as a dietary supplement for people on inadequate or unusual diets or with medical conditions that increase the need for it. (wholehealthmd.com)
  • If you have type 2 diabetes, your doctor may prescribe biotin to increase your glucose levels to functional amounts. (chiroeco.com)
  • Also, biotin can be produced naturally in your bowel and it's only needed in very small amounts by your body to support normal function. (lloydspharmacy.com)
  • Other carboxylases, decarboxylases, and a transcarboxylase are also dependent on biotin as an enzyme cofactor. (chiro.org)
  • There are 5 biotin-dependent carboxylases each of which exists as an inactive apoform. (medscape.com)
  • Intracellular distribution of biotin corresponds to known localization of biotin-dependent enzymes (carboxylases). (dsm.com)
  • Biotin-dependent carboxylases include acetyl-CoA carboxylase (ACC), propionyl-CoA carboxylase (PCC), 3-methylcrotonyl-CoA carboxylase (MCC), geranyl-CoA carboxylase, pyruvate carboxylase (PC), and urea carboxylase (UC). (springer.com)
  • In mammals, biotin serves as a covalently bound coenzyme for 5 carboxylases: acetyl-CoA carboxylases 1 and 2, propionyl-CoA carboxylase (PCC), 5 3-methylcrotonyl-CoA carboxylase (MCC), and pyruvate carboxylase ( 1 ). (pubmedcentralcanada.ca)
  • Holocarboxylase synthetase (HLCS) catalyzes the binding of biotin to all 5 carboxylases and, therefore, plays a pivotal role in biotin-dependent metabolic pathways ( 1 ). (pubmedcentralcanada.ca)
  • Biotinidase catalyzes the release of biotin from breakdown products of carboxylases and, therefore, plays a crucial role in biotin recycling ( 1 ). (pubmedcentralcanada.ca)
  • Biotin status is typically assessed by quantifying the urinary excretion of biotin and its major metabolites (~120 nmoles/d), the activity of PCC or MCC in lymphocytes, and the abundance of biotinylated carboxylases in cell extracts ( 1 ). (pubmedcentralcanada.ca)
  • Why do people take biotin? (webmd.com)
  • Can Men Safely Take Biotin? (livestrong.com)
  • What do I need to tell my doctor BEFORE I take Biotin Sublingual Tablets? (drugs.com)
  • What are some things I need to know or do while I take Biotin Sublingual Tablets? (drugs.com)
  • Back in the 1940s, a researcher demonstrated that adding high biotin foods into the diet of a lactating mother reduced symptoms of cradle cap in nursing infants. (whfoods.com)
  • For biotin, however, there is no UL because adverse effects of high biotin intake have not been determined. (wikipedia.org)
  • The biotin / lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. (ebi.ac.uk)
  • Egg whites however are said to contain a compound that binds to biotin and keeps it from being absorbed. (hubpages.com)
  • The 1.3S subunit binds the outer and central subunits of the enzyme together, and its biotin serves as carboxyl carrier between subsites on the central and outer subunits where each partial reaction occurs. (pnas.org)
  • The image above highlights that in biotin-free patient samples, the analyte to be tested successfully binds to the biotinylated antibody and the labelled antibody ultimately ensuring accurate measurement. (randox.com)
  • Biotin, a B vitamin, is an essential nutrient that is naturally present in some foods and available as a dietary supplement. (nih.gov)
  • People who smoke might have low biotin levels and may need a biotin supplement. (medlineplus.gov)
  • Those taking antibiotics should supplement their diets with biotin. (encyclopedia.com)
  • A supplement, lipoic acid, may also increase the need for biotin. (webmd.com)
  • If you're concerned you aren't getting enough from your diet , you can take a biotin supplement, or use external products that contain biotin (for nails, skin and hair). (selfgrowth.com)
  • Treatment is lifelong dietary supplement with biotin. (wikipedia.org)
  • A combination supplement that contains chromium picolinate and biotin may reduce health care costs by improving blood sugar management in people with Type 2 diabetes, according to a study published in the August 2005 issue of the journal 'Disease Management. (livestrong.com)
  • The benefits of the biotin-containing supplement enhanced the benefits of diabetes medications. (livestrong.com)
  • In a 2007 study published by The American Journal of the Medical Sciences , biotin was shown to lower fasting blood glucose levels in people with type 2 diabetes mellitus when combined with chromium picolinate, the supplement form of chromium. (foodinsight.org)
  • When biotin is used for hair and nail care, it is typically consumed in the form of a dietary supplement. (foodinsight.org)
  • Biotin is also widely available in supplement form. (foodinsight.org)
  • Unfortunately, some people won't be able to supplement themselves with biotin without suffering from pimples. (infobarrel.com)
  • Though most often biotin is taken in supplement form, it's also used in cosmetic products as well for topical use and other things. (hubpages.com)
  • In clinical studies that have been done, biotin has shown to not be very bio-available, meaning that when taken in supplement form, it's difficult for the digestive system to absorb it for use. (hubpages.com)
  • I took this directly from the label of a popular biotin supplement. (hubpages.com)
  • So while a person might not have an adverse reaction to the biotin itself, they made experience side effects or allergic reaction to the other components inside the supplement. (hubpages.com)
  • So obviously some of the biotin in the supplement was able to be absorbed and utilized by the body. (hubpages.com)
  • However, the need to supplement this nutrient is uncommon because it is rare to have biotin deficiency, says Mayo Clinic. (reference.com)
  • Keep reading to find out how to add biotin to your diet, what to look for in a biotin supplement, possible side effects, and more. (healthline.com)
  • You can fulfill your recommended biotin allowance through your diet or by taking a biotin supplement. (healthline.com)
  • If you want to correct a biotin deficiency or intensify biotin's effects, consider taking a nutritional supplement. (chiroeco.com)
  • And there, calling out to you from the packed shelves of the drug store, is a supplement containing biotin , a B vitamin that, according to the bottle, "Supports Healthy Hair, Skin & Nails! (goodhousekeeping.com)
  • There is no reliable blood test [for biotin deficiency] so sometimes it is helpful to supplement. (goodhousekeeping.com)
  • Biotin is often touted as a supplement that may help strengthen nails and improve the appearance of skin, however these claims are only supported by a small number of studies . (lloydspharmacy.com)
  • Early research shows that taking biotin with thiamine does not reduce symptoms more than taking thiamine alone. (medlineplus.gov)
  • There isn't a good laboratory test for detecting low biotin levels, so this condition is usually identified by its symptoms, which include thinning of the hair (frequently with loss of hair color) and red scaly rash around the eyes, nose, and mouth. (medlineplus.gov)
  • Because it is synthesized in the gut, deficiency symptoms of biotin are rare. (encyclopedia.com)
  • Symptoms of extreme biotin deficiency include elevation of cholesterol levels, heart problems, and paralysis. (encyclopedia.com)
  • Biotin might decrease insulin resistance and nerve symptoms related to type 2 diabetes . (webmd.com)
  • That could be why some people think biotin can cure psoriasis or reduce symptoms, but there have been no conclusive scientific studies to prove this. (healthline.com)
  • There are no known toxic symptoms from biotin. (medlineplus.gov)
  • Signs and symptoms of biotin deficiency can develop in persons of any age, race, or gender. (newworldencyclopedia.org)
  • The signs and symptoms of biotin deficiency include hair loss that progresses in severity to include loss of eye lashes and eye brows in severely deficient subjects. (newworldencyclopedia.org)
  • Symptoms of biotin deficiency in infants include weak muscle tone, sluggishness, and delayed development . (nih.gov)
  • What are the symptoms of Biotin Deficiency? (beauty-cosmetic-guide.com)
  • If you're experiencing these symptoms, we advise you visit your GP to rule out biotin deficiency as well as other health conditions. (lloydspharmacy.com)
  • Visible indicators of biotin deficiency include hair loss and a scaly red facial rash, while neurological symptoms include fatigue, depression, numbness or tingling sensations in the limbs, and hallucinations. (fsu.edu)
  • Nearly 50% of pregnant women appear to be deficient in biotin, which could result in birth defects (at least according to animal studies). (encyclopedia.com)
  • There are, however, no studies that show any benefit in any case where the subject is not actually biotin deficient. (newworldencyclopedia.org)
  • The role of biotin in nutrition and the changes that result when it is deficient are not clear. (thepigsite.com)
  • It's rare to be deficient in biotin. (umm.edu)
  • People who have been on parenteral nutrition -- nutrition given intravenously -- for a long period of time, those taking antiseizure medication or antibiotics long-term, and people with conditions like Crohn's disease that make it hard to absorb nutrients, are more likely to be deficient in biotin. (umm.edu)
  • Evidence suggests that biotin catabolism is accelerated in pregnancy and that about half of pregnant women in the United States are marginally biotin deficient ( 1 ). (pubmedcentralcanada.ca)
  • Not only is biotin important for the processing of our food into energy, it also helps support healthy hair, nails and skin and can assist in the re-growth of healthy skin and hair in those who are deficient in the vitamin. (lloydspharmacy.com)
  • The importance of methionine residues for the catalysis of the biotin enzyme, transcarboxylase. (ebi.ac.uk)
  • [ 3 ] The enzyme holocarboxylase synthetase (HCLS ) catalyzes the addition of biotin (biotinylation) to the inactive apoform, which leads to the formation of the active carboxylase. (medscape.com)
  • Low activity of this enzyme causes a failure to recycle biotin from biocytin. (wikipedia.org)
  • The intestinal enzyme biotinidase, found in pancreatic secretions and in the brush border membranes of all three parts of the small intestine, frees biotin, which is then absorbed from the small intestine. (wikipedia.org)
  • This enzyme is also called biotin carboxylase (component of acetyl CoA carboxylase). (wikipedia.org)
  • Such conditions include a genetic deficiency of the enzyme (biotinidase) needed by the body to utilize biotin, intestinal malabsorption, seborrheic dermatitis in infancy and an inability to absorb biotin as a result of surgical removal of the stomach. (wholehealthmd.com)
  • When deficiencies of the vitamin do occur it is usually due to one of two different genetic enzyme disorders that effectively result in an increase of the bodily requisite for biotin. (fsu.edu)
  • The body needs biotin on a daily basis since it is not stored to any great extent. (encyclopedia.com)
  • It's also known as vitamin H. Your body needs biotin to help convert certain nutrients into energy. (healthline.com)
  • Conversely, many drugs can lower biotin levels, including some antibiotics . (webmd.com)
  • Eating raw egg whites on a regular basis can also lower biotin levels in the body. (webmd.com)
  • For example, treatment for at least 1 year with antiseizure medications (used to treat epilepsy ) can significantly lower biotin levels. (nih.gov)
  • Although there is no evidence that biotin interacts with any medication, there are some medications that may lower biotin levels. (umm.edu)
  • Biotin helps turn the carbohydrates, fats, and proteins in the food you eat into the energy you need. (nih.gov)
  • Biotin in food is bound to proteins. (wikipedia.org)
  • Digestive enzymes reduce the proteins to biotin-bound peptides. (wikipedia.org)
  • Biotin is used as a cofactor for enzymes that break down carbohydrates, proteins and fats. (foodinsight.org)
  • However, 18 hours after an intraventricular injection, approximately 35% of the [ 3 H]biotin remaining in brain had been covalently incorporated into proteins, presumably into carboxylase apoenzymes. (springer.com)
  • However, [ 3 H]biotin is very slowly incorporated covalently into proteins in brain in vivo. (springer.com)
  • A high performance blend of powerful ProVitamin B7 biotin iNFuses nutrients into every strand, while plumping collagen adds volume and dimension, and hydrolyzed wheat proteins strengthen, for thicker, fuller, healthier looking hair. (goodguide.com)
  • Biotin can be a valuable tool to combat yeast infections , which are notoriously difficult to fight. (encyclopedia.com)
  • Standard preparations are available in 10 mcg, 50 mcg, and 100 mcg tablets and contain either simple biotin or a complex with brewer's yeast. (umm.edu)
  • Many foods contain some biotin. (nih.gov)
  • for example, plant variety and season can affect the biotin content of cereal grains, and certain processing techniques (e.g., canning) can reduce the biotin content of foods [ 12 ]. (nih.gov)
  • We also have only a partial understanding of how much biotin is found in commonly eaten foods. (whfoods.com)
  • Many of the foods that our charts say do not contain biotin actually more accurately contain an unknown quantity of the vitamin. (whfoods.com)
  • While we are still learning about how rich many of the World's Healthiest Foods are as biotin sources, we already know that we have tomatoes as an excellent source of biotin, and almonds as a very good source. (whfoods.com)
  • Happily, many of the biotin-rich foods we list are also strong sources of fiber, which make them great staples for people with blood sugar problems. (whfoods.com)
  • Although this research hasn't been followed up in more modern settings, we think that nursing moms could consider focusing on foods high in both biotin and omega-3 fatty acids , including salmon and eggs from pasture-raised chickens . (whfoods.com)
  • Although their contribution is not fully noted in the charts on this page, tofu, mushrooms, and many types of seeds can be biotin-rich foods. (whfoods.com)
  • Other animal foods like milk and meat can make up another chunk of your biotin requirement. (whfoods.com)
  • It is also known as vitamin H. Because biotin is present in so many different kinds of foods, deficiency is rare. (webmd.com)
  • We get biotin in foods naturally. (webmd.com)
  • Can you get biotin naturally from foods? (webmd.com)
  • Biotin occurs naturally in many foods. (webmd.com)
  • We get biotin from foods such as eggs and avocado, so deficiency is rare, though not unheard of. (healthline.com)
  • Biotin is found in a wide variety of natural foods. (eatingwell.com)
  • What foods contain biotin? (ehow.co.uk)
  • Biotin deficiency is rare as it is readily available in many foods. (ehow.co.uk)
  • There are a variety of foods rich in biotin. (ehow.co.uk)
  • http://www.ehow.co.uk/facts_4910664_what-foods-contain-biotin.html. (ehow.co.uk)
  • Biotin is a B-vitamin found in many foods. (nih.gov)
  • According to the Global Fortification Data Exchange, biotin deficiency is so rare that no countries require that foods be fortified. (wikipedia.org)
  • The U.S. Department of Agriculture's (USDA's) National Nutrient Database does not list the biotin content of foods or provide lists of foods containing biotin. (foodinsight.org)
  • But if you'd like to increase your intake, you can add more biotin-rich foods into your diet. (healthline.com)
  • Biotin is a vitamin found naturally in various foods (see Dietary Advice for more information). (wholehealthmd.com)
  • Less-processed versions of the foods listed above contain more biotin. (umm.edu)
  • As biotin is a water-soluble vitamin, it cannot be stored inside the body, and it needs to be constantly ingested through the foods we eat. (lloydspharmacy.com)
  • Biotin is an important component of enzymes in the body that break down certain substances like fats, carbohydrates, and others. (medlineplus.gov)
  • Biotin has been used in conjunction with other nutrients as part of weight loss programs, as it aids in the digestion and breakdown of fats. (encyclopedia.com)
  • This symptom occurs because biotin is necessary to build healthy fats in the skin. (whfoods.com)
  • Biotin is a B vitamin (B-7), but it's also sometimes called vitamin H. It supports healthy cell growth and helps our bodies metabolize fats. (healthline.com)
  • Its melting point is 232° to 233°C. Free biotin is soluble in dilute alkaline solutions and hot water and practically insoluble in fats and organic solvents. (dsm.com)
  • Adequate biotin is required for healthy nails and hair, and biotin deficiency is known to be a factor in balding and the premature graying of hair. (encyclopedia.com)
  • In addition, biotin is important for the health of your hair, skin and nails. (medicalnewstoday.com)
  • The clinical presentation of biotin deficiency involves abnormalities of the hair, skin, nails and the central nervous system. (medscape.com)
  • Biotin (pronounced BYE-oh-tin) is a water-soluble vitamin that our bodies need to provide us with energy and maintain the health of our hair, nails and skin. (foodinsight.org)
  • Biotin is widely promoted for its ability to enhance the health of our hair, nails and skin. (foodinsight.org)
  • But most notably, biotin has been known for a long time to have a positive effect on the hair and nails. (hubpages.com)
  • Biotin is an essential nutrient to help restore radiant, healthy hair and skin while building strong nails. (walgreens.com)
  • Biotin is often recommended for strengthening hair and nails, and it's found in many cosmetic products for hair and skin. (umm.edu)
  • So should you plunk down your dollars in hopes that biotin will get you the glossy, voluminous hair and long, strong nails you're hoping for? (goodhousekeeping.com)
  • Will biotin help improve my skin and nails? (lloydspharmacy.com)
  • At LloydsPharmacy we have a number of products designed to care for your nails, including Pink chewable biotin gummies . (lloydspharmacy.com)
  • Biotin requirements increase during pregnancy and lactation. (encyclopedia.com)
  • In 2002, an investigation outlined the need for supplemental biotin during pregnancy. (encyclopedia.com)
  • Studies of biotin status during pregnancy suggest marginal biotin deficiency, occurring in a significant number of otherwise normal pregnancies, may be teratogenic. (chiro.org)
  • Marginal biotin deficiency has been demonstrated in pregnancy and lactation, but the clinical significance is uncertain. (medscape.com)
  • The risks and benefits of taking biotin during pregnancy are uncertain. (reference.com)
  • The purpose of this study is to estimate the number of pregnant women who, during pregnancy, have low levels of the vitamin biotin. (clinicaltrials.gov)
  • This information will be used to later determine if low biotin levels during pregnancy cause certain birth defects. (clinicaltrials.gov)
  • Biotin is also important for normal embryonic growth, making it a critical nutrient during pregnancy. (umm.edu)
  • Adequate daily intakes for biotin from food, according to the National Academy of Sciences, are listed below. (umm.edu)
  • Researchers suggest that biotin be included in prenatal multivitamin formulas. (encyclopedia.com)
  • Animal studies suggest that biotin is necessary for healthy fetal development, but more research is needed in humans. (medicalnewstoday.com)
  • Intake recommendations for biotin and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine [ 1 ]. (nih.gov)
  • Recommendations for pantothenic acid and biotin, as well as other nutrients, are provided in the Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board at the Institute of Medicine. (medlineplus.gov)
  • Witch hazel extract helps to normalize oil production to prevent an oily scalp, while the super-vitamin biotin provides essential nutrients to the hair follicle to support healthy hair growth. (sephora.com)
  • Biotin: Provides essential nutrients to the hair follicle that support healthy hair growth. (sephora.com)
  • Abnormally low urinary excretion of biotin is an indicator of biotin deficiency, as is abnormally high excretion of 3-hydroxyisovaleric acid (higher than 3.3 mmol/mol creatinine) or 3-hydroxyisovalerylcarnitine (higher than 0.06 mmol/mol creatinine) resulting from reduced activity of MCC [ 2 , 7 , 8 ]. (nih.gov)
  • Consumption of biotin as part of a normal diet results in urinary excretion of biotin and biotin metabolites. (wikipedia.org)
  • Low MCC activity causes increased urinary excretion of 3-hydroxyisovaleric acid and its carnityl conjugate, which is used to diagnose biotin deficiency. (pubmedcentralcanada.ca)
  • Biotin first came to the attention of researchers for what is still its most famous characteristic-that raw egg whites can interfere with biotin nutrition. (whfoods.com)
  • Regular consumption of raw egg whites can cause biotin deficiency. (ehow.co.uk)
  • Because humans and other mammals cannot synthesize biotin, it must be derived from dietary sources and de novo synthesis by intestinal bacteria. (chiro.org)
  • In humans, biotin deficiency can cause lethargy, depression and a scaly rash around the eyes, nose and mouth. (latimes.com)
  • There is currently no evidence to suggest that taking large quantities of biotin is toxic to humans. (medicalnewstoday.com)
  • Information on biotin transport, tissue deposition and storage in animals and humans is very limited. (dsm.com)
  • Chronic alcoholics and those on long-term anticonvulsants could develop biotin deficiency because of impaired intestinal uptake of the vitamin. (medscape.com)
  • Efficient conservation of biotin, together with the recycling of biocytin released from the catabolism of biotin-containing enzymes, may be as important as intestinal bacterial synthesis of the vitamin in meeting biotin requirements (Bender, 1992). (dsm.com)
  • Biotin is also synthesized in the gastrointestinal tract by intestinal microorganisms, but not enough for this to be the sole source. (healthcastle.com)
  • In 2002, one company started clinical trials testing a combination of chromium picolinate and biotin for treatment of type 2 diabetes. (encyclopedia.com)
  • A clinical trial in the in Spring 2007 edition of the "Journal of Cardiometabolic Syndrome" points out that biotin along with chromium can help lower the blood cholesterol levels, which may in turn reduce the risk of high blood pressure and other cardiovascular diseases. (livestrong.com)
  • Preliminary research indicates that a combination of biotin and chromium might improve blood sugar control in some people with type 2 diabetes, but biotin alone doesn't seem to have the same effect. (umm.edu)
  • Taking biotin does not seem to help improve rash in infants. (medlineplus.gov)
  • However, the study only included three infants, and all had biotin deficiency before treatment. (medicalnewstoday.com)
  • These biotin-containing enzymes participate in important metabolic pathways, such as the production of glucose and fatty acids. (medicalnewstoday.com)
  • Biotin-containing enzymes help initiate this process. (medicalnewstoday.com)
  • Biotin assists enzymes that activate reactions important for the production of fatty acids. (medicalnewstoday.com)
  • 13 ] Biotin has been found to attach to histones, a process catalyzed by the enzymes holocarboxylase synthetase [ 14 ] and biotinidase. (chiro.org)
  • Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme [ PMID: 1526981 ]. (ebi.ac.uk)
  • A prominent nutrient-drug interaction is that biotin-dependent enzymes are reduced with the epilepsy drug carbamazepine (Rathman et al. (dsm.com)
  • Biotin is a coenzyme for five carboxylase enzymes, which are involved in the digestion of carbohydrates, synthesis of fatty acids, and gluconeogenesis. (wikipedia.org)
  • In the study, participants took 6 micro-moles per deciliter of biotin per day for 28 days and showed increased activity of several enzymes that regulate blood sugar in both the diabetic and non-diabetic participants. (livestrong.com)
  • 1973). In rats and pigs, biliary excretion of biotin and metabolites is negligible (Zempleni et al. (dsm.com)
  • 1989a, b) reported similar findings in that absorption of free biotin in the post-ileal digestive tract was about 8% as efficient as that from a similar labeled dose of orally administered biotin. (dsm.com)
  • After degradation of the biotinylated carboxylase into biocytin, it is further degraded by biotinidase to release free biotin, which is recycled in holocarboxylase synthesis. (genome.jp)
  • A prenatal multiple vitamin and mineral formula that contains biotin may help prevent a deficiency. (adventisthealthcare.com)
  • As biotin deficiency in pregnant animals results in birth defects, it seems reasonable to use a prenatal multiple vitamin and mineral formula that contains biotin. (adventisthealthcare.com)
  • But if you want give it a go, make sure you get a brand that, well, at least contains biotin. (goodhousekeeping.com)
  • Biotin deficiency is very rare in the United States. (nih.gov)
  • Biotin deficiency is very rare. (foodinsight.org)
  • Biotin may improve glucose levels and reduce pain from diabetic nerve damage. (adventisthealthcare.com)
  • Biotin is a B vitamin needed to process glucose. (adventisthealthcare.com)
  • In a pilot trial, people with type 1 diabetes given 16 mg of biotin per day for one week experienced 50% reductions in fasting glucose levels. (adventisthealthcare.com)
  • Biotin is necessary for formation of fatty acids and glucose, which are used as fuels by the body. (mayoclinic.org)
  • Biotin is utilized by every cell in the body and contributes to the health of skin, hair, nerves, bone marrow , sex glands, and sebaceous glands. (encyclopedia.com)
  • Other uses of biotin -- for conditions like cradle cap , hepatitis , hair loss , and depression -- are unsupported or untested. (webmd.com)
  • Signs of biotin deficiency include hair loss and skin rash . (healthline.com)
  • Although a key reputation for biotin is in hair-loss products, a combination of biotin and STAY-C® 50(patent granted) also demonstrated significant synergies in skin care applications, where it reduced age spots and evened the skin tone. (dsm.com)
  • Biotin is sometimes used in attempts to stop hair from graying or thinning. (latimes.com)
  • Biotin may help hair growth. (medicalnewstoday.com)
  • Biotin may improve hair growth, reduce skin rashes, and encourage healthy nail growth. (medicalnewstoday.com)
  • Although rare, biotin deficiency can occur and will result in dry skin and hair loss. (selfgrowth.com)
  • There has been a recent increase in the use of biotin is hair care products. (selfgrowth.com)
  • Both conventional and natural hair care companies are striving to include biotin in their products, because it has been proven to help nourish hair, while also conserving strength and increasing natural texture. (selfgrowth.com)
  • Biotin conditioner adds natural moisture back into your hair and boosting shine. (selfgrowth.com)
  • Items in Biotin Xtreme Hair Care store on eBay! (ebay.com)
  • Biotin has beneficial impact on the strength of the fingernails and boosts the growth of the hair. (infobarrel.com)
  • For those of you who have taken in Biotin for hair loss, how much did you take? (healingwell.com)
  • So can biotin be absorbed into the body topically through the skin and the hair? (hubpages.com)
  • Biotin for Hair Growth: Does It Work? (healthline.com)
  • To date, there's only limited evidence to suggest that increased biotin intake may help promote hair growth. (healthline.com)
  • Although more research is needed to assess its effects on hair growth, biotin does have several proven benefits. (healthline.com)
  • Does biotin work to grow new hair? (reference.com)
  • According to WebMD, any claims of biotin working to grow hair are not scientifically supported. (reference.com)
  • Biotin deficiency may lead to dermatitis, hair loss, high blood cholesterol levels, and heart problems. (wholehealthmd.com)
  • Many over-the-counter products, particularly those marketed for hair, skin, and nail growth, contain biotin 100-fold of recommended daily intake. (nih.gov)
  • Biotin and Vitamin B5 thicken hair and revitalise elasticity, while Ginseng and lavender extracts repair split ends and minimize future breakage. (ethicalsuperstore.com)
  • This natural Biotin conditioner from Jason works to strengthen and repair weak, damaged hair as it gently moisturises. (ethicalsuperstore.com)
  • Made with natural and organic ingredients, Jason Biotin Conditioner is paraben, SLS and phthalate free, enriched with biotin and Vitamin C to revitalise vitality and elasticity while jojoba seed oil deeply nourishes and ginseng extract repairs split ends, minimising future breakage so hair appears healthier and grows stronger. (ethicalsuperstore.com)
  • You get the ProVitamin B7 (biotin) that infuses into your hair strands while the collagen adds volume and dimension to give you thicker, fuller looking hair. (naturallycurly.com)
  • The biotin strengthens your hair and balances the pH levels while the aloe vera moisturizes and reduces inflammation and dandruff. (naturallycurly.com)
  • So why are people taking biotin for hair and nail growth? (goodhousekeeping.com)
  • There are tons of reasons you may have thinning hair, most of which have zero to do with a biotin deficiency. (goodhousekeeping.com)
  • Biotin is an important vitamin for hair health, It keeps skin and nail enamel in perfect health. (beauty-cosmetic-guide.com)
  • It plays a vital role in preventing hair loss and there are no side effects due to consumption of biotin. (beauty-cosmetic-guide.com)
  • Biotin makes your hair healthy, good looking, and strong. (beauty-cosmetic-guide.com)
  • Will biotin stop hair loss? (lloydspharmacy.com)
  • A number of studies have been carried out on the effects of taking biotin on hair loss . (lloydspharmacy.com)
  • Your GP will be able to help rule out biotin deficiency and determine the cause of your hair loss - always follow the treatment advice of a healthcare professional. (lloydspharmacy.com)
  • 2017. The FDA warns that biotin may interfere with lab tests: FDA Safety Communication . (medsafe.govt.nz)
  • Biotin is a coenzyme and a B vitamin. (webmd.com)
  • According to WebMD, biotin is a coenzyme and a B vitamin. (reference.com)
  • Brain pyruvate carboxylase and the pathophysiology of biotin-dependent diseases. (springer.com)