Biosensing Techniques
Nanotechnology
Conductometry
Silicon
Lab-On-A-Chip Devices
Microdevices that combine microfluidics technology with electrical and/or mechanical functions for analyzing very small fluid volumes. They consist of microchannels etched into substrates made of silicon, glass, or polymer using processes similar to photolithography. The test fluids in the channels can then interact with different elements such as electrodes, photodetectors, chemical sensors, pumps, and valves.
Electrochemical Techniques
Gold
Surface Plasmon Resonance
A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.
Molecular Imprinting
Streptavidin
Metal Nanoparticles
Transistors, Electronic
Nanowires
Semiconductors
Micro-Electrical-Mechanical Systems
Microtechnology
Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.
Nanostructures
Microfluidics
Nanopores
Graphite
Optical Phenomena
Electrochemistry
Microfluidic Analytical Techniques
Quantum Dots
Optical Devices
Nanotubes
Equipment Failure Analysis
Limit of Detection
Electrodes
Surface Properties
Glucose Oxidase
An enzyme of the oxidoreductase class that catalyzes the conversion of beta-D-glucose and oxygen to D-glucono-1,5-lactone and peroxide. It is a flavoprotein, highly specific for beta-D-glucose. The enzyme is produced by Penicillium notatum and other fungi and has antibacterial activity in the presence of glucose and oxygen. It is used to estimate glucose concentration in blood or urine samples through the formation of colored dyes by the hydrogen peroxide produced in the reaction. (From Enzyme Nomenclature, 1992) EC 1.1.3.4.
Aptamers, Nucleotide
Quartz Crystal Microbalance Techniques
Interferometry
Enzymes, Immobilized
Ion-Selective Electrodes
Electronics
Avidin
Polymers
Nanoparticles
Electric Power Supplies
Biotin
Porosity
Spectrum Analysis, Raman
Nanotubes, Carbon
Photons
Silicon Dioxide
Oxides
Silver
Immunoassay
Membranes, Artificial
Adsorption
Antibodies
Microscopy, Electron, Scanning
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Direct interaction of lignin and lignin peroxidase from Phanerochaete chrysosporium. (1/3180)
Binding properties of lignin peroxidase (LiP) from the basidiomycete Phanerochaete chrysosporium against a synthetic lignin (dehydrogenated polymerizate, DHP) were studied with a resonant mirror biosensor. Among several ligninolytic enzymes, only LiP specifically binds to DHP. Kinetic analysis revealed that the binding was reversible, and that the dissociation equilibrium constant was 330 microM. The LiP-DHP interaction was controlled by the ionization group with a pKa of 5.3, strongly suggesting that a specific amino acid residue plays a role in lignin binding. A one-electron transfer from DHP to oxidized intermediates LiP compounds I and II (LiPI and LiPII) was characterized by using a stopped-flow technique, showing that binding interactions of DHP with LiPI and LiPII led to saturation kinetics. The dissociation equilibrium constants for LiPI-DHP and LiPII-DHP interactions were calculated to be 350 and 250 microM, and the first-order rate constants for electron transfer from DHP to LiPI and to LiPII were calculated to be 46 and 16 s-1, respectively. These kinetic and spectral studies strongly suggest that LiP is capable of oxidizing lignin directly at the protein surface by a long-range electron transfer process. A close look at the crystal structure suggested that LiP possesses His-239 as a possible lignin-binding site on the surface, which is linked to Asp-238. This Asp residue is hydrogen-bonded to the proximal His-176. This His-Asp...proximal-His motif would be a possible electron transfer route to oxidize polymeric lignin. (+info)Absorption of solar radiation by an ellipsoid sensor simulated the human body. (2/3180)
Assessment of heat gain in man caused by solar radiation is one of the most important problems in research of the human heat balance outdoors. The purpose of the present study was to investigate a new method for estimation of solar heat income. Absorption of short wave radiation (direct, diffuse and reflected) was measured with an ellipsoid sensor representing a simple, physical model of man. Measurements were performed in climatic chamber with the use of an iodide CSI solar lamp. The absorbed quantity of solar radiation varied as a result of sun altitude as well as of a colour and insulation of fabric covering the ellipsoid sensor. The new coefficients derived from our investigations for estimating doses of absorbed solar radiation should be applicable for a standing man. They correlate better with mean skin temperature observed on subjects outdoor than previous results obtained based on a cylinder as an analogue model of man. The ellipsoid sensor covered by a black fabric absorbed about 6 times more of solar radiation than when covered by a white textile. (+info)T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics. (3/3180)
The T cell surface glycoprotein CD8 enhances T cell antigen recognition by binding to MHC class I molecules. We show that human CD8 alphaalpha binds to the MHC class I molecule HLA-A2 with an extremely low affinity (Kd approximately 0.2 mM at 37 degrees C) and with kinetics that are between 2 and 3 orders of magnitude faster than reported for T cell receptor/peptide-MHC interactions. Furthermore, CD8 alphaalpha had no detectable effect on a T cell receptor (TCR) binding to the same peptide-MHC class I complex. These binding properties provide an explanation as to why the CD8/MHC class I interaction is unable to initiate cell-cell adhesion and how it can enhance TCR recognition without interfering with its specificity. (+info)Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. (4/3180)
The kinetics of interaction between TCR and MHC-peptide show a general relationship between affinity and the biological response, but the reported kinetic differences between antigenic and antagonistic peptides are very small. Here, we show a remarkable difference in the kinetics of TCR interactions with strong agonist ligands at 37 degrees C compared to 25 degrees C. This difference is not seen with antagonist/positive selecting ligands. The interaction at 37 degrees C shows biphasic binding kinetics best described by a model of TCR dimerization. The altered kinetics greatly increase the stability of complexes with agonist ligands, accounting for the large differences in biological response compared to other ligands. Thus, there may be an allosteric, as well as a kinetic, component to the discrimination between agonists and antagonists. (+info)Evaluation of relative contributions of two enzymes supposed to metabolise hydrogen peroxide in Paracoccus denitrificans. (5/3180)
A biosensor exploiting an electrochemically mediated enzyme-catalysed reaction was used to quantify relative contributions of cytoplasmic catalase and periplasmic cytochrome c peroxidase to the overall rate of hydrogen peroxide breakdown in cells of Paracoccus denitrificans. The effects of antimycin (an inhibitor of electron flow to cytochrome c peroxidase), the reaction rate versus substrate concentration profiles for the whole cells and subcellular fractions, and the time courses of oxygen concentration demonstrated a profound decrease in the capacity of cytochrome c peroxidase to reduce H2O2 under in vivo conditions. The reason is suggested to be a competition for available electrons between the enzyme and terminal oxidases metabolising oxygen produced by catalase. (+info)Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. (6/3180)
Lipoprotein lipase and the receptor-associated protein (RAP) bind to overlapping sites on the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP). We have investigated if lipoprotein lipase interacts with the RAP binding but structurally distinct receptor sortilin/neurotensin receptor-3. We show, by chemical cross-linking and surface plasmon resonance analysis, that soluble sortilin binds lipoprotein lipase with an affinity similar to that of LRP. The binding was inhibited by heparin and RAP and by the newly discovered sortilin ligand neurotensin. In 35S-labeled 3T3-L1 adipocytes treated with the cross-linker dithiobis(succinimidyl propionate), lipoprotein lipase-containing complexes were isolated by anti-sortilin antibodies. To elucidate function in cells, sortilin-negative Chinese hamster ovary cells were transfected with full-length sortilin and shown to express about 8% of the receptors on the cell surface. These cells degraded 125I-labeled lipoprotein lipase much faster than the wild-type cells. The degradation was inhibited by unlabeled lipoprotein lipase, indicating a saturable pathway, and by RAP and heparin. Moreover, inhibition by the weak base chloroquine suggested that degradation occurs in an acidic vesicle compartment. The results demonstrate that sortilin is a multifunctional receptor that binds lipoprotein lipase and, when expressed on the cell surface, mediates its endocytosis and degradation. (+info)Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1. (7/3180)
Certain class II MHC-peptide complexes are resistant to SDS-induced dissociation. This property, which has been used as an in vivo as well as an in vitro peptide binding assay, is not understood at the molecular level. Here we have investigated the mechanistic basis of SDS stability of HLA-DR1 complexes by using a biosensor-based assay and SDS-PAGE with a combination of wild-type and mutant HLA-DR1 and variants of hemagglutinin peptide HA306-318. Experiments with wild-type DR1 along with previously published results establish that the SDS-stable complexes are formed only when the hydrophobic pocket 1 (P1) is occupied by a bulky aromatic (Trp, Phe, Tyr) or an aliphatic residue (Met, Ile, Val, Leu). To further explore whether the SDS sensitivity is primarily due to the exposed hydrophobic regions, we mutated residue beta Gly86 at the bottom of P1 to tyrosine, presumably reducing the depth of the pocket and the exposure of hydrophobic residues and increasing the contacts between subunits. In direct contrast to wild-type DR1, the peptide-free mutant DR1 exists as an alpha/beta heterodimer in SDS. Moreover, the presence of a smaller hydrophobic residue, such as alanine, as P1 anchor with no contribution from any other anchor is sufficient to enhance the SDS stability of the mutant complexes, demonstrating that the basis of SDS resistance may be localized to P1 interactions. The good correlation between SDS sensitivity and the exposure of hydrophobic residues provides a biochemical rationale for the use of this assay to investigate the maturation of class II molecules and the longevity of the complexes. (+info)Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin. (8/3180)
Domain IV of mouse perlecan, which consists of 14 immunoglobulin superfamily (IG) modules, was prepared from recombinant human cell culture medium in the form of two fragments, IV-1 (IG2-9, 100 kDa) and IV-2 (IG10-15, 66 kDa). Both fragments bound to a heparin column, being eluted at ionic strengths either below (IV-2) or above (IV-1) physiological level, and could thus be readily purified. Electron microscopy demonstrated an elongated shape (20-25 nm), and folding into a native structure was indicated by immunological assay and CD spectroscopy. Solid-phase and surface plasmon resonance assays demonstrated strong binding of fragment IV-1 to fibronectin, nidogen-1, nidogen-2 and the laminin-1-nidogen-1 complex, with Kd values in the range 4-17 nM. The latter binding apparently occurs through nidogen-1, as shown by the formation of ternary complexes. Only moderate binding was observed for fibulin-2 and collagen IV and none for fibulin-1 and BM-40. Fragment IV-2 showed a more restricted pattern of binding, with only weaker binding to fibronectin and fibulin-2. None of these activities could be demonstrated for recombinant fragments corresponding to the N-terminal perlecan domains I to III. This indicates a special role for domain IV in the integration of perlecan into basement membranes and other extracellular structures via protein-protein interactions. (+info)
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Novel biosensor of membrane protein proximity based on fluorogen activated proteins.
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Simultaneous live cell imaging using dual FRET sensors with a single excitation light<...
Droplet-based microfluidics
This technique is capable of running in excess of 2 million PCR reactions in addition to a 100,000-fold increase in the ... The above experiment by Shamsi et al, alludes to the main use for electrochemical detection in microfluidics; biosensing for ... Eventually a technique was developed to create monodisperse biodegradable microgels by making O/W emulsions in an in-line ... Another technique for creating particle-loaded microdroplets is the use of lipid-hydrogel nanoparticles that can be manipulated ...
Rolling circle replication
In addition to the amplification function in biosensing applications, RCA technique can be applied to the construction of DNA ... Selector-technique Ali, M. Monsur; Li, Feng; Zhang, Zhiqing; Zhang, Kaixiang; Kang, Dong-Ku; Ankrum, James A.; Le, X. Chris; ... This technique combines two fields: RCA, which allows nucleotide amplification, and immunoassay, which uses antibodies specific ... This amplification technique is named as Rolling circle amplification (RCA). Different from conventional DNA amplification ...
Mary Ryan (engineer)
She works with the heritage sector to develop new materials and conservation techniques. She has worked with the Science Museum ... including the toxicity of nanoparticles and development of plasmonic materials for biosensing. ... where she developed in situ electrochemical systems using synchrotron radiation-based techniques. Ryan is an expert in ...
Bio-MEMS
Optical detection includes fluorescence-based techniques, chemiluminescence-based techniques, and surface plasmon resonance ( ... The most common bioreceptors used in biosensing are based on antibody-antigen interactions, nucleic acid interactions, ... One common use for this technique is in detecting nucleotide mismatches in DNA because the variation in mass caused by the ... Conventional micromachining techniques such as wet etching, dry etching, deep reactive ion etching, sputtering, anodic bonding ...
Genetically modified organism
... a technique called phage display). These structures have potential uses for energy storage and generation, biosensing and ... A number of techniques are available for inserting the isolated gene into the host genome. Bacteria can be induced to take up ... A number of techniques are available for inserting the isolated gene into the host genome. Recent advancements using genome ... Gene targeting techniques, which creates double-stranded breaks and takes advantage on the cells natural homologous ...
Surface plasmon resonance microscopy
This technique is convenient to study the label free and real time interactions of cells on the surface. So SPRM can be served ... Anker, J, N; Hall, W, P; Lyandres, O; Shah, N, C; Zhao, J; Van Duyne, R, P (2008). "Biosensing with plasmonic nanosensors". ... In SPRM technique, plasmon surface polariton (PSP) waves are used for illumination. In simple words, SPRI technology is an ... As is seen in the image the remarkable contrast of the image is due to the high sensitivity of the technique.[citation needed] ...
Carbon nanotube supported catalyst
Inorganic compounds are directly formed on the surface of CNTs via a variety of techniques including electrochemical techniques ... Because of the excellent biological compatibility of Au, they are so frequently used in biosensing, medical and other related ... Hydrothermal techniques are developed in recent years. The advantage of this method is to get crystalline particles or films ... The characterization techniques of CNTs supported catalysts are varied. The most common methods include X-ray diffraction (XRD ...
Photonic metamaterial
A stacking technique for SRRs was published in 2007 that uses dielectric spacers to apply a planarization procedure to flatten ... Other potential applications include biosensing using nanoscale particles to deflect light to angles steep enough to travel ... Nanoscale fabrication techniques exist to accomplish subwavelength geometries. Metals such as gold, silver, aluminum and copper ... Fabrication techniques include electron beam lithography, nanostructuring with a focused ion beam and interference lithography ...
Biointerface
Being a FET device can also be taken advantage of when using single SiNWs as biosensing devices. SiNW sensors are nanowires ... scientists who have developed new spectroscopic techniques to interrogate these molecules at the solid-liquid interface, and ... and regenerative medicine Computational and modeling approaches to biointerfaces Membranes and membrane-based biosensing ...
IRIS (biosensor)
By using interferometric techniques, nanometer changes can be detected. Applications for IRIS include microarray format ... is a system that can be used as a biosensing platform capable of high-throughput multiplexing of protein-protein, protein-DNA, ...
Dawn Bonnell
The ability to visualize the atomic structure of surfaces and interfaces, and has applications in catalysis, biosensing and ... Techniques, and Applications. Wiley-Blackwell. ISBN 978-0471248248. Bonnell, Dawn (2013). Scanning Probe Microscopy For Energy ...
Single-walled carbon nanohorn
CO2 laser ablation technique is utilized to produce the first SWNHs at room temperature in absence of a metal catalyst. The CO2 ... Special designed SWNHs nanocomposites have versatile biosensing applications. One example is the sandwich nanohybrid of SWNHs- ... biosensing, drug delivery, gas storage and catalyst support for fuel cell. Single-walled carbon nanohorns are an example of the ... have been investigated by a combination of several techniques to show the electron-transfer process between the porphyrins and ...
Surface plasmon polariton
The excitation of SPPs is frequently used in an experimental technique known as surface plasmon resonance (SPR). In SPR, the ... These devices include ultra-compact plasmonic interferometers for applications such as biosensing, optical positioning and ...
Joseph Wang
His contributions in these directions have been of major impact in the development of electrochemical sensing techniques and ... a novel motion-based DNA biosensing, and nanomachine-enabled isolation of biological targets, such as cancer cell ... Monitoring of Environmental Pollutants in Field Electrochemistry of Nucleic Acids and Proteins Electrochemical Techniques in ...
Nanobiotechnology
Three American patients have received whole cultured bladders with the help of doctors who use nanobiology techniques in their ... biosensing, biological mechanisms such as mechanosensation), nanoscience of disease (e.g. genetic disease, cancer, organ/tissue ... Measurement in biology using wave guide techniques, such as dual-polarization interferometry, is another example. Applications ...
Jennifer Doudna
The CRISPR system created a new straightforward way to edit DNA and there was a rush to patent the technique. Doudna and UC ... The business is focused on improving access to bio sensing tests which address "challenges across healthcare, agriculture, ... Meanwhile, UC Berkeley and co-applicants' patent to cover the general technique was also granted. To further cloud the issue, ... "This court battle will decide who will make a fortune from gene-editing technique". Bloomberg. Retrieved September 2, 2018. ...
Biosensor
Many techniques exist to detect DNA, which is usually a means to detect organisms that have that particular DNA. DNA sequences ... The use of affinity binding receptors for purposes of biosensing has been proposed by Schultz and Sims in 1979 and was ... These techniques are mainly used in agriculture, food technology and biomedicine. In medical applications biosensors are ... Many optical biosensors are based on the phenomenon of surface plasmon resonance (SPR) techniques. This utilises a property of ...
Nanowire
The technique fuses wires as small as 10 nm. For nanowires with diameters less than 10 nm, existing welding techniques, which ... This method is investigated both for the synthesis of metallic nanowires in electronic components and for biosensing ... In one technique, the polyol synthesis, ethylene glycol is both solvent and reducing agent. This technique is particularly ... This technique allows to produce individual nanowires below 20 nm in width in a scalable way out of several metallic and metal ...
Porous silicon
Pentane drying The technique uses pentane as the drying liquid instead of water. In doing so the capillary stress is reduced ... Ouyang, Huimin (2005). "Biosensing using porous silicon photonic bandgap structures". In Du, Henry H (ed.). Photonic Crystals ... and Ingeborg Uhlir at the Bell Labs in the U.S. At the time, the Ulhirs were in the process of developing a technique for ... Hence, several appropriate techniques have been developed to minimize the risk of cracks formed during drying. Supercritical ...
A. A. Griffith Medal and Prize
He is renowned for his understanding of the mechanics of materials, and for pioneering techniques that led to the study of ... Her nano-materials for biosensing have enabled the most sensitive facile enzyme detection to date and she is actively pursuing ...
Printed electronics
This method uses techniques such as thermal, e-beam, sputter and other traditional production technologies to deposit materials ... 3.0.CO;2-E. Thomas, D.J. (2016). "Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing". ... This is an active research area, however, and print-compatible metal deposition techniques have been demonstrated that adapt to ... 2005). "Utilizing roll-to-roll techniques for manufacturing source-drain electrodes for all-polymer transistors". Synthetic ...
Stefan Seeger
He also developed techniques for the manipulation of biological particles. He has so far published more than 100 scientific ... 38 (4) 724-32 (1999) T. Ruckstuhl, M. Rankl, S. Seeger: Highly sensitive biosensing using a Supercritical Angle Fluorescence ( ...
E-textiles
This in Finished approach entails the use of textile fabrication techniques to form woven or nonwoven fabrics with the ... These properties render them ideal substrates for electrochemical biosensing, which has been demonstrated with the detection of ... finished garments by simply stitching the electrodes at the appropriate locations on the garment or using deposition techniques ...
Reverse transcription polymerase chain reaction
This technique is easy to use since designing of probes is not necessary given lack of specificity of its binding. However, ... the one-step approach is a relatively convenient solution for the rapid detection of target RNA directly in biosensing.[ ... The combined RT-PCR and qPCR technique has been described as quantitative RT-PCR or real-time RT-PCR (sometimes even called ... The emergence of novel fluorescent DNA labeling techniques in the past few years has enabled the analysis and detection of PCR ...
Bioactive paper
Zhao, W.; Brook, M.A.; Li, Y.F. "Design of gold nanoparticle-based colorimetric biosensing assays." ChemBioChem, 2008, 9 (15), ... Kong, Fanzhi; Hu, Yim Fun (2012). "Biomolecule immobilization techniques for bioactive paper fabrication". Analytical and ...
Protein detection
C and the time is set to 15 minutes for the current abstraction technique. The current abstraction technique can restrain the ... Engineering the bioelectronic interface : applications to analyte biosensing and protein detection. Davis, Jason J., Royal ... Three different techniques can be used in raw ground beef: the VIDAS ultraperformance E. coli test (ECPT UP), a noncommercial ... These methods and techniques can be conveyed to lab environment easily. The original and traditional methods were designed and ...
Plantago asiatica
Zhang, Shou-wen; Zhong, Wei-guang; Li, Feng-gin; Cao, Lan (2012). "Study on Optimal Fertilizer Techniques for Standardized ... Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method". Evidence-Based Complementary and ...
Cees Dekker
STM and nanolithography techniques were used to demonstrate that these nanotubes are quantum wires at the single-molecule level ... and resolved the mechanism of biosensing with carbon nanotubes 2008, first observation of protein-coated DNA translocation ... and discovery of a new technique for fabricating solid-state nanopores for DNA translocation 2004, discovery of new physics in ... and demonstration of an AFM technique for single-molecule manipulation of nanotubes 2001, discovery of single-electron ...
Helen Gleeson
Her current research includes liquid crystals for laser protection and biosensing. She looks to develop a flexible and cheap ... She is interested in novel experimental techniques to characterise liquid crystals, and in 2016 contributed a chapter on Raman ...
Nonlinear optics
Four-wave mixing technique[edit]. For the four-wave mixing technique, we can describe four beams (j = 1, 2, 3, 4) with electric ... "Optical trapping-assisted SERS platform for chemical and biosensing applications: Design perspectives". Coordination Chemistry ... The reversed beam is called a conjugate beam, and thus the technique is known as optical phase conjugation[21][22] (also called ... With this technique, the 1064 nm output from Nd:YAG lasers or the 800 nm output from Ti:sapphire lasers can be converted to ...
Nanomedicine
Wu P, Yan XP (June 2013). "Doped quantum dots for chemo/biosensing and bioimaging". Chemical Society Reviews. 42 (12): 5489-521 ... which is a clinically used technique for the purification of blood and is based on surface adsorption. These advantages are ...
Enzymatic biofuel cell
The beginning concept applying enzymatic biofuel cells for self-powered biosensing applications was introduced in 2001.[13] ... The former technique is possible only with certain types of enzymes whose activation sites are close to the enzyme's surface, ... which meant that it was unusable until after immobilization techniques were devised.[2] In addition, developers of enzymatic ...
Silver nanoparticle
A new, very promising wet-chemical technique was found by Elsupikhe et al. (2015).[12] They have developed a green ... "Metal-Enhanced Fluorescence from Silver Nanowires with High Aspect Ratio on Glass Slides for Biosensing Applications". J. Phys ... Though many different techniques for silver nanoprism synthesis exist, several methods employ a seed-mediated approach, which ... In addition to the seed mediated technique, silver nanoprisms can also be synthesized using a photo-mediated approach, in which ...
Nanomaterials
"Refinement of the Nanoparticle Emission Assessment Technique into the Nanomaterial Exposure Assessment Technique (NEAT 2.0)". ... which have been used for wide applications in such as biosensing, bioimaging, tumor diagnosis,[38] antibiofouling and more. In ... There are traditional techniques developed during the 20th century in interface and colloid science for characterizing ... There is also a group of traditional techniques for characterizing surface charge or zeta potential of nano-particles in ...
Plasmon
"New technique lights up the creation of holograms". Phys.org. Retrieved 24 September 2013.. ... 2011). "A review on functionalized gold nanoparticles for biosensing applications". Plasmonics. 6 (3): 491-506. doi:10.1007/ ... observed via near field infrared optical microscopy techniques[15][16] and infrared spectroscopy.[17] Potential applications of ...
Nanomaterial-based catalyst
Some techniques that can be used to characterize functionalized nanomaterial catalysts include X-ray photoelectron spectroscopy ... The nanozymes have found wide applications in many areas, from biosensing and bioimaging to therapeutics and water treatment. ...
Plasmonic metamaterial
More recently, researchers used a novel self-folding technique to create a three-dimensional array of split-ring resonators ... 2015). "Graphene-gold metasurface architectures for ultrasensitive plasmonic biosensing". Advanced Materials. 27 (40): 1-7. doi ... The material was created using epitaxy inside a vacuum chamber with a technique known as magnetron sputtering. The material ... Graphene also accommodates surface plasmons, observed via near field infrared optical microscopy techniques and infrared ...
Potential applications of graphene
In 2015 the technique was adapted to produce stacked, 3-D supercapacitors. Laser-induced graphene was produced on both sides of ... 2015). "Graphene-gold metasurface architectures for ultrasensitive plasmonic biosensing" (PDF). Advanced Materials. 27 (40): 1- ... Press Release (January 6, 2015). "'Flying Carpet' Technique Uses Graphene to Deliver One-Two Punch of Anticancer Drugs". North ... In February 2013 researchers announced a novel technique to produce graphene supercapacitors based on the DVD burner reduction ...
Transition metal dichalcogenide monolayers
This technique produces small samples of monolayer material, typically about 5-10 micrometers in diameter. Large quantities of ... Syu, Yu-Cheng; Hsu, Wei-En; Lin, Chih-Ting (2018-01-01). "Review-Field-Effect Transistor Biosensing: Devices and Clinical ... This technique is often used in the preparing electrical devices with molybdenum disulfide components because the nanosheets ... Electroplating Among the techniques that have been used to deposit molybdenum disulfide is electroplating. Ultra-thin films ...
Stöber process
Applying supercritical drying techniques, a Stöber silica aerogel with a specific surface area of 700 m2 g−1 and a density of ... a convenient approach to preparing silica nanoparticles for applications including intracellular drug delivery and biosensing. ... Highly effective thermal insulators known as aerogels can also be prepared using Stöber methods, and Stöber techniques have ... In addition, experimental data from techniques including microgravity analysis and variable pH analysis agree with predictions ...
Slot-waveguide
2008-03-28). "Label-free optical biosensing with slot-waveguides". Optics Letters. The Optical Society. 33 (7): 708-10. doi: ... and nano-fabrication techniques. These processing tools include electron beam lithography, photolithography, chemical vapour ... or photo-lithography and dry etching techniques whereas in horizontal slot-waveguides the slot and strips thicknesses are ... defined by a thin-film deposition technique or thermal oxidation. Thin film deposition or oxidation provides better control of ...
Surface plasmon resonance
Related complementary techniques include plasmon waveguide resonance, QCM, extraordinary optical transmission, and dual- ... Liedberg, Bo; Nylander, Claes; Lunström, Ingemar (1983). "Surface plasmon resonance for gas detection and biosensing". Sensors ... the technique can be extended to surface plasmon resonance imaging (SPRI). This method provides a high contrast of the images ...
I-motif DNA
Using a variety of biophysical techniques, i-motif DNA has been characterized to be derived from centromeres and promoter ... Applications of i-motifs are centered around biomedical topics, including bio-sensing, drug delivery systems, and molecular ...
Sangeeta N. Bhatia
She successfully applied techniques from photolithography to petri dishes, to create a substrate that would support growth of a ... She was a co-editor of Microdevices in Biology and Medicine (2009) and Biosensing: International Research and Development (2005 ... She and her coworkers have also used techniques from 3D printing to create a lattice of sugar as a framework for a synthetic ... July 15, 2006). Biosensing: International Research and Development. Springer Science & Business Media. ISBN 9781402040580. ...
Kinetic exclusion assay
An example of this technique has been employed for sensitive detection of environmental contaminants in near real-time. A ... Sensing and Bio-Sensing Research. 7: 115-120. doi:10.1016/j.sbsr.2016.02.003. PMC 4767017. PMID 26925369.. ...
Ion track
This technique is applied to the counting and sizing of individual red blood cells, bacteria, and virus particles. pH Sensor: ... "Developing synthetic conical nanopores for biosensing applications". Molecular BioSystems. 3 (10): 667-685. doi:10.1039/ ... The technique can be used to increase the aspect ratio. Repeated irradiation and processing: A two-step irradiation and etching ... "Counting and sizing of submicron particles by the resistive pulse technique". Review of Scientific Instruments. 41 (7): 909-916 ...
Electromagnetic metasurface
Metasurface-empowered novel bioimaging and biosensing devices have also emerged and reported recently. For many optically based ... Luo, Xiangang; Ishihara, Teruya (2004). "Surface plasmon resonant interference nanolithography technique". Appl. Phys. Lett. 84 ... R. Ahmed (2020). "Tunable Fano‐resonant metasurfaces on a disposable plastic‐template for multimodal and multiplex biosensing ... 2015). "Graphene-gold metasurface architectures for ultrasensitive plasmonic biosensing". Advanced Materials. 27: 6163-6169. ...
Timeline of biotechnology
"New technique makes thousands of semi-synthetic photosynthesis cells". New Atlas. 11 May 2020. Archived from the original on 25 ... The nanowires have a range of advantages over silicon nanowires and the memristors may be used to directly process biosensing ... "Scientists Create New, More Powerful Technique To Edit Genes". NPR. Archived from the original on 21 October 2019. Retrieved 21 ... 1983 - The Polymerase Chain Reaction (PCR) technique is conceived. 1990 - First federally approved gene therapy treatment is ...
Localized surface plasmon
Some techniques frequently used to characterize surface plasmons are dark-field microscopy, UV-vis-NIR spectroscopy, and ... "Nanoparticle enhanced surface plasmon resonance biosensing: Application of gold nanorods". Optics Express. 17 (21): 19041-19046 ... Nanostructures exhibiting LSP resonances are used to enhance signals in modern analytical techniques based on spectroscopy. ...
WikiGenes - Biosensing Techniques
High impact information on Biosensing Techniques. *Using a FRET biosensor, we find that LGN behaves as a conformational switch ... Psychiatry related information on Biosensing Techniques. *The biosensor operated at 0.450 V, had a fast response time (t90% , ... Associations of Biosensing Techniques with chemical compounds. *Using genetically targeted PIP2-sensitive inward rectifier ... Gene context of Biosensing Techniques. *Using an optical biosensor, we found that CD4-induced (CD4i) epitopes recognized by ...
Direct electrochemistry of hemoglobin at a graphene gold nanoparticle composite film for nitric oxide biosensing
... electrode through a simple dropping technique. Direct electr … ... Biosensing Techniques / instrumentation * Biosensing Techniques ... Direct electrochemistry of hemoglobin at a graphene gold nanoparticle composite film for nitric oxide biosensing Sensors (Basel ... electrode through a simple dropping technique. Direct electrochemistry and electrocatalysis of the hemoglobin-modified ...
OSA | Schottky-contact plasmonic dipole rectenna concept for biosensing
Microwave Theory and Techniques, IEEE Transactions on (1). J. McSpadden, L. Fan, and K. Chang, "Design and experiments of a ... Theoretical biosensing performance of surface plasmon polariton Bragg gratings Kholoud Gazzaz and Pierre Berini. Appl. Opt. 54( ... F. Mazzotta, G. Wang, C. Hgglund, F. Hk, and M. P. Jonsson, "Nanoplasmonic biosensing with on-chip electrical detection," ... F. Mazzotta, G. Wang, C. Hgglund, F. Hk, and M. P. Jonsson, "Nanoplasmonic biosensing with on-chip electrical detection," ...
Research Keyword Faculty Listing | Yale School of Medicine
Biosensing, Diagnostics & Imaging
Nanofabrication Techniques for Fully Integrated Sensing Platforms. M. Mujeeb-U-Rahman, D. Adalian, M. Sencan, A. Scherer. ... In vitro biosensing based on magnetically induced motion of magnetic nanoparticles. A. Dangl, G. Kokkinis, F. Keplinger, I. ... Biosensing, Diagnostics & Imaging Chapter 1. A Nanodiamond is Forever: Functionalizable fluorescent nanodiamonds that do not ...
Dynamic Luminescent Biosensors Based on Peptides for Oxygen Determination | IntechOpen
This chapter summarizes the fundamentals of biosensing techniques based on fluorescence spectroscopy and the protagonism of ... 2. Principles and evolution of biosensing techniques. Biosensors are devices that can perform the measurement of a ... This chapter summarizes the fundamentals of biosensing techniques based on fluorescence spectroscopy and the protagonism of ... In biosensing, materials based on graphene had promoted efficient detection of biomarkers and have proportioned an important ...
Predicting aggression to others in youth with autism using a wearable biosensor. - PubMed - NCBI
Quantum-Enhanced Plasmonic Sensing Could Improve Biosensing, Chemical Detection | Research & Technology | May 2018 | Photonics...
Characterization of a gold coated cantilever surface for biosensing applications | EPJ Techniques and Instrumentation | Full...
EPJ Techniques and Instrumentationvolume 2, Article number: 1 (2015) , Download Citation ... Characterization of a gold coated cantilever surface for biosensing applications. *Ann-Lauriene Haag1. , ... allowing signal averaging techniques to be used. If clean gold surfaces are used, the resultant reproducible time dependent ... different cleaning procedures by quantifying surface cleanliness electrochemically in situ and using surface science techniques ...
OMsignal's Biosensing Clothing That Monitors Heart Rate and Activity (VIDEO) | Medgadget
Theme: "Exploring the latest Techniques in Orthopedics and Osteoporosis". This conference concentrates on the newest and ... OMsignals Biosensing Clothing That Monitors Heart Rate and Activity (VIDEO). September 6th, 2013 Gaurav Diagnostics, Military ... OMSignals product stands out from the numerous biosensing smart products such as bracelets, watches and phones, as this ... techniques to identify those genetic pathways, and the use of genetics and genomics as tools to develop therapeutics. ...
Vullev Research Group
Dynamic biosensing. We explore the dynamics of fluorescence staining as an unprecedented source of information about the ... Print-and-peel (PAP) fabrication techniques, developed in our lab, allow for facile and expedient prototyping of microdevices, ... Bioinspired abiotic interfaces set the foundation for our biosensing research. Fundamental and advanced concepts of physical ... organic chemistry and biophysics, along with various synthetic, fabrication and analytical techniques, allow us to address ...
Category:Biotechnology - Wikimedia Commons
Category:Biotechnology - Wikimedia Commons
IJMS | Free Full-Text | Microfluidic Biosensing Systems Using Magnetic Nanoparticles | HTML
Their multi-functionality is what makes them ideal candidates as the active component in miniaturized on-chip biosensing ... sensitive and cost-effective on-chip biosensing systems that directly translate the presence of certain bioanalytes (e.g., ... magnetic fields can be well tuned and applied either externally or from a directly integrated solution in the biosensing system ... The reported technique for simultaneous MNP manipulation and detection was demonstrated on a linear array of bistable 1 μm × 8 ...
Analysis of the role of the interleukin-2 receptor gamma chain in ligand binding
David N. Beratan, R.J. Reynolds Professor of Chemistry
Materials | Free Full-Text | Graphene versus Multi-Walled Carbon Nanotubes for Electrochemical Glucose Biosensing | HTML
CV and amperometric i-t curve techniques were used for the electrochemical characterization of the biosensors. CV was also used ... Graphene versus Multi-Walled Carbon Nanotubes for Electrochemical Glucose Biosensing by Dan Zheng 1,2, Sandeep Kumar Vashist 1, ... Zheng, D.; Vashist, S.K.; Al-Rubeaan, K.; Luong, J.H.T.; Sheu, F.S. Mediatorless amperometric glucose biosensing using 3- ... Guo, C.X.; Li, C.M. Direct electron transfer of glucose oxidase and biosensing of glucose on hollow sphere-nanostructured ...
T. Randall Lee - PubMed - NCBI
Sensors | Free Full-Text | Augmented Reality as a Telemedicine Platform for Remote Procedural Training
Low Temperature Plasma Treatment of Cancer: Towards In-Vivo Implementation - Doctoral College
International Journal of Signal and Imaging Systems Engineering (IJSISE) Inderscience Publishers - linking academia, business...
Optical biosensing techniques. *External Reflection techniques, backscattering multispectral polarimetry. *Total internal ... Linear and Nonlinear Techniques for Image Processing. *Advanced image enhancement and processing algorithms ... Image System Design, Image Instrumentation and Measuring Techniques. *Image system design parameters, such as spectral response ... IJSISE provides the interface between basic research, algorithms and techniques in signal and image processing/analysis/ ...
Remote sensing of gene expression in Planta: transgenic plants as monitors of exogenous stress perception in extraterrestrial...
Oxidation etching induced dual-signal response of carbon dots/silver nanoparticles system for ratiometric optical sensing of HO...
... and reduce Rayleigh scattering based on a hyphenated technique of fluorescence and ... Biosensing Techniques; Blood Glucose; Carbon; Glucose Oxidase; Humans; Hydrogen Peroxide; Limit of Detection; Metal ... and reduce Rayleigh scattering based on a hyphenated technique of fluorescence and second-order Rayleigh scattering (SRS). The ...
Synthesis of Nano-Praseodymium Oxide for Cataluminescence Sensing of Acetophenone in Exhaled Breath. | AMERICAN ELEMENTS ®
Innovative optical lactate biosensing through the design of nanostructured materials
Faculté des sciences et techniques de lingénieur. Institut des matériaux. Laboratoire de technologie des poudres. Jury: Prof. ... Innovative optical lactate biosensing through the design of nanostructured materials. Pérez Anguiano, Oswaldo Javier. Advisors ... The functionalization of nanostructured silica films for L-lactate biosensing was explored using two different enzymes. As a ... These hybrid systems incorporate cytochrome C (CytC) as a biosensing element. Its optical properties depend on its oxidation ...
Biosensing, Diagnostics & Imaging
Nanofabrication Techniques for Fully Integrated Sensing Platforms. M. Mujeeb-U-Rahman, D. Adalian, M. Sencan, A. Scherer, ... Biosensing, Diagnostics & Imaging II - Posters 1:30. Expo Hall A. -. The scavenging of reactive oxygen species and the ... Biosensing, Diagnostics & Imaging I - Posters 4:00. Expo Hall A. -. Synthesis and Characterization of Functionalized Magnetic ... In vitro biosensing based on magnetically induced motion of magnetic nanoparticles. A. Dangl, G. Kokkinis, F. Keplinger, I. ...
Multilayer Thin Films: Sequential Assembly of Nanocomposite Materials / Edition 2 by Gero Decher | 9783527316489 | Hardcover |...
Washless (Titration) LbL Technique. Formation of LbL Shells on Nanocores. Drug Release Study. Conclusions. CELLULOSE FIBERS AND ... CONTROLLED ARCHITECTURES IN LBL FILMS FOR SENSING AND BIOSENSING. Introduction. LbL-Based Sensors and Biosensors. Special ... Experimental Techniques. Analysis of QCR Data. VOLUME 2. PART II: Applications. ELECTROSTATIC AND COORDINATIVE SUPRAMOLECULAR ... Preparation Techniques for Polyelectrolyte Multilayers. Types of Polyelectrolytes. Preparation Parameters. Influence of ...
Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing - Lab on a Chip (RSC...
The nanofluidic grating sensor was fabricated using standard microfabrication techniques as shown in Fig. 2. Silicon-on- ... Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing†. F. Purr ab, M. Bassu b, ... 14-17 and for biosensing.18-20 In chemical and biological sensing, many powerful device concepts have been proposed based on ... 3-5 and biosensing.6-10 Several technologies for refractive index measurement have been previously described in the literature ...
Biosensing with optical fiber gratings : Nanophotonics
Moreover, we review the recent development in OFG-based biosensing and identify some of the key challenges for practical ... Different nanofabrication techniques have been proposed in literature during the time, ranging from the classical techniques ( ... 4.2 Nucleic acid-based biosensing. 4.2.1 DNA probe-based biosensing. OFGs have been used in biosensor development coupled to ... 4.1 Antibody-based biosensing. In the development of the first grating-based immunoassay, DeLisa et al. [43] used an LPG, ...
NanoparticlesBiosensorsApplicationsNanostructuresElectrochemical TechniquesSensitivityInstrumentationOpticalDiagnosticsBiomoleculesBioelectronicsBiomedicalAntibodiesMembrane proteinsChemistryPlatformsFluorescentIsothermalNanomaterialsFluorescenceProteinsFunctionalizationEnzymesAdvantagesImagingRemotelyMagneticProtein componentsBiosensorMass spectrometryDevicesChipHighResearchSystemsConventional
Nanoparticles7
- Here, a new ratiometric optical sensing strategy for HO detection is developed by etching silver nanoparticles (AgNPs) to deactivate fluorescence resonance energy transfer (FRET) and reduce Rayleigh scattering based on a hyphenated technique of fluorescence and second-order Rayleigh scattering (SRS). (americanelements.com)
- At the nanobiofabrication group of Tufts University, we exploit several unique properties of tobacco mosaic virus (TMV) for facile synthesis of catalytically active palladium (Pd) nanoparticles and fabrication of high capacity biosensing platforms. (aiche.org)
- These functionalized nanoparticles were investigated with several techniques. (nsti.org)
- They have developed a device and technique , called bubble-pen lithography , that can efficiently handle nanoparticles-the tiny pieces of gold, silicon and other materials used in nanomanufacturing. (phys.org)
- This review discusses the recent advances in DNA biosensing techniques based on metal nanoparticles. (aspbs.com)
- This translational process relies on the availability of high-quality nanoparticles with precisely engineered surfaces and biosensing mechanisms that allow detection with high sensitivity and specificity. (sciencemag.org)
- Coupling this technique with gold nanoparticles in our research has produced new platforms for biosensors, chemical patterning, and anti-counterfeiting applications. (umass.edu)
Biosensors7
- This chapter summarizes the fundamentals of biosensing techniques based on fluorescence spectroscopy and the protagonism of state-of-the-art luminescent biosensors in a wide range of scientific areas, from environmental monitoring to diagnostics and decease treatment, focusing on the paramount contribution of biosensors based on the Förster Resonance Energy Transfer (FRET) transducing mechanism. (intechopen.com)
- The major in Biosensing and Bioelectronics combines both theoretical and practical studies in designing, developing, fabricating and characterizing biosensors, biomedical devices and medical instrumentations. (aalto.fi)
- The work described in this dissertation focused on the development of novel techniques for functionalization of carbon nanotubes to enable their use as components of biosensors for use in physiological conditions. (oregonstate.edu)
- The proposed research will be focused on characterisation of biochemically modified surfaces of electrodes using advanced scanning probe microscopic (SPM) techniques and application of the achieved results for development of advanced electrochemical biosensors. (muni.cz)
- Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. (schweitzer-online.de)
- Nanoparticle biosensors have the potential to enhance or supersede current analytical techniques, and their introduction could have a great impact in research and clinical practice. (sciencemag.org)
- Looking toward high-impact applications, the main challenges are to develop techniques to synthesize reproducible high-quality nanoparticle biosensors on a mass scale and to maximize performance in physiological conditions. (sciencemag.org)
Applications20
- Nanoantennas are key optical components for several applications including photodetection and biosensing. (osapublishing.org)
- These advantages make the fluorescence spectroscopy a powerful technique, paving the way to the most wished rapid and low-cost sensing in a wide range of biological and environmental applications and point-of-care diagnostics for real-time monitoring of physiological conditions. (intechopen.com)
- During the last several years magnetoresistive (MR)-based detection methods in combination with microfluidics have received significant research interest in biosensing applications [ 1 , 2 ]. (mdpi.com)
- The scope of this thesis is the synthesis of nanostructured materials, their functionalization and use for optical lactate biosensing applications. (epfl.ch)
- Moreover, we review the recent development in OFG-based biosensing and identify some of the key challenges for practical applications. (degruyter.com)
- Such readout techniques do not lend themselves to rapid automation, limiting screening applications to libraries of only a couple hundred or so molecules. (bio-medicine.org)
- UPecs: electrochemical techniques are on excellent level and the applications of SECM are internationally recognized. (muni.cz)
- Exploiting novel 1D/2D field-effect devices for biosensing applications. (lirmm.fr)
- We have evaluated five bioconjugation chemistries for immobilizing DNA onto silicon substrates for microfluidic biosensing applications. (springer.com)
- The technique forms the basis for a wide range of biosensing applications using modified metal surfaces. (queensu.ca)
- However these coatings lack robustness and are sensitive even to exposure to air, greatly limiting their applications and making the technique expensive. (queensu.ca)
- understanding the most common techniques in the field of magnetic biosensing and their applications. (fz-juelich.de)
- Sol-gel chemistry allows the immobilization of organic molecules of biological origin on suibtable solid supports, permitting their integration into biosensing devices widening the possibility of local applications. (eurekaselect.com)
- According to the researchers, the use of highly efficient GaN LEDs has distinct advantages for implanted biosensing applications where a long device life is required. (medgadget.com)
- In this review, we highlight the current state of research on NAAO addresses the formation, properties and numbers of applications are further demonstrated for the application of catalytic, biosensing and nanostructure templates synthesis. (eurekaselect.com)
- All the nanostructures used for the biosensing applications have two characteristics. (nanowerk.com)
- Label-free biosensing has been an active research area with applications to biomolecular interactions as well as early-stage disease diagnosis. (pnas.org)
- Optical sensing techniques are being employed in widespread applications ranging from aerospace to electronics, process control and medicine. (illinois.edu)
- These broad applications including optical biosensing, electrochemical DNA biosensing, molecular separation, optofluidics and drug delivery are reviewed in separated book chapters. (springer.com)
- En conséquence, on s'attend à ce que les nanotubes envahissent des applications clef telles que les écrans à émission de champ, le stockage d'énergie, les composites structuraux, la nanoélectronique, les capteurs et les actuateurs, etc. (archives-ouvertes.fr)
Nanostructures2
- Using microbubbles to gently transport the particles, the bubble-pen lithography technique can quickly arrange particles in various shapes, sizes, compositions and distances between nanostructures. (phys.org)
- Next, a novel and low-cost coating deposition technique capable of production of several types of nanostructures is introduced through simple calculations and several illustrations. (springer.com)
Electrochemical Techniques1
- The immunosensor design was targeted for carcinoembryonic antigen (CEA), an important biomarker for screening the colorectal cancer, by electrochemical techniques, namely electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SVW). (eurekaselect.com)
Sensitivity5
- Fluorescence spectroscopy has been revolutionizing the field of life sciences and clinical routines such as diagnostics and biosensing, due to its impressive sensitivity and the biocompatibility of many fluorescent organic compounds, which allows one to probe biological processes in vivo in noninvasive bioimaging procedures. (intechopen.com)
- Sensing methods of remarkable sensitivity, reliability, and selectivity based on fluorescence spectroscopy dominates the field of sensing and biosensing. (intechopen.com)
- A label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence ( Δ n ) to promote sensitivity in detecting biomolecules. (spiedigitallibrary.org)
- Agile R100 is based on a breakthrough electrical technique called Field Effect Biosensing that enables affordable kinetics without compromising sensitivity and reliability. (prweb.com)
- Unfortunately, current detection techniques such as ISO method 6579, fluorescent-antibody (FA), enzyme-linked immunosorbent assay (ELISA), or polymerase chain reaction (PCR) are time-consuming, cumbersome, and have limited sensitivity. (nanowerk.com)
Instrumentation1
- A time-domain-based amplifier concept is proposed to obtain high-voltage gains with low power consumption and at an ultra-low supply voltage of 0.35 V. A prototype instrumentation amplifier designed using the proposed technique in the 180 nm technology consumes 210 nW of power and 0.1 mm 2 of the active area. (digchip.com)
Optical5
- Optical fiber gratings (OFGs) are being increasingly proposed as optical platforms for label-free biosensing as promising alternatives to the most traditional ones based on surface plasmon resonance (SPR) or on interferometric configurations. (degruyter.com)
- In contrast, optical biosensing has benefited from in a large variety of specialized tools. (comsol.com)
- We are also pursuing other techniques, including optical biosensing, isothermal titration calorimetry and global multi-method modeling approaches. (nih.gov)
- The unique optical properties of many nanomaterials make them ideal for biosensing. (sciencemag.org)
- The research outlined in this paper summarizes the Army Aviation and Missile Research, Development, and Engineering Center's (AMRDEC's) comparative use of nanoporous membranes, carbon nanotubes, and optical spectroscopic configured sensing techniques for detecting degradation in rocket motor propellant. (spie.org)
Diagnostics1
- Nanomedical Diagnostics ("Nanomed") is a life science company based in San Diego, CA. Nanomed has developed a breakthrough electrical assay based on proprietary Field Effect Biosensing (FEB) technology that delivers sensitive label-free kinetic characterization of biomolecular interactions for accelerated drug discovery. (prweb.com)
Biomolecules2
- In recent years, there has been rapidly growing interest in developing hand held, sensitive and cost-effective on-chip biosensing systems that directly translate the presence of certain bioanalytes (e.g., biomolecules, cells and viruses) into an electronic signal. (mdpi.com)
- A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. (umassmed.edu)
Bioelectronics1
- The majors offered are Bioinformatics and Digital Health, Biomedical Engineering, Biosensing and Bioelectronics, Biosystems and Biomaterials Engineering, Complex Systems , and Human Neuroscience and Technology with a possibility to combine different fields with minor and elective studies. (aalto.fi)
Biomedical1
- The RCA mechanism is widely used in molecular biology and biomedical nanotechnology, especially in the field of biosensing (as a method of signal amplification). (wikipedia.org)
Antibodies1
- Capturing biological objects like EVs with antibodies is well described in the literature through different biosensing techniques. (rsc.org)
Membrane proteins1
- They are decorated with surface proteins, which are membrane proteins that can be targeted by biochemical techniques to isolate EVs from background particles. (rsc.org)
Chemistry4
- Fundamental and advanced concepts of physical organic chemistry and biophysics, along with various synthetic, fabrication and analytical techniques, allow us to address important scientific and engineering questions at a broad range of spatial and temporal scales: i.e., from sub-nanometer to hundreds of micrometers, and from femtoseconds to minutes. (google.com)
- Our core methods are X-ray crystallography, enzymology, and other classical protein chemistry techniques for biophysical characterization. (dtu.dk)
- Overall, simple sol-gel chemistry was effective at the biosensing design and the presented approach can be a potential method for screening CEA in point-of-care, due to the simplicity of fabrication, short response time and low cost. (eurekaselect.com)
- Liliana A.A.N.A. Truta and M. Goreti F. Sales, "Sol-Gel Chemistry in Biosensing Devices of Electrical Transduction: Application to CEA Cancer Biomarker", Current Topics in Medicinal Chemistry (2015) 15: 256. (eurekaselect.com)
Platforms2
- In the biosensing area, we have enlisted TMV's dual functionality coupled with robust replica molding (RM) for facile fabrication of high-capacity biomolecular assembly platforms. (aiche.org)
- We envision that our approach to seamlessly integrate these three traits would lead to promising fabrication schemes for high-capacity biosensing platforms. (aiche.org)
Fluorescent1
- Frog melanophores cultured on fluorescent microbeads: Biomimic-based biosensing. (diva-portal.org)
Isothermal1
- As a simplified version of natural rolling circle replication, an isothermal DNA amplification technique, rolling circle amplification was developed. (wikipedia.org)
Nanomaterials2
- Second, the technique has the potential for large-scale, low-cost manufacturing of nanomaterials and devices. (phys.org)
- Zheng says he hopes to advance bubble-pen lithography by developing a multiple-beam processing technique for industrial-level production of nanomaterials and nanodevices. (phys.org)
Fluorescence3
- DNA sequencing and fragment analysis, fluorescence staining for bioimaging and fluorescence immunoassays are all based on fluorescence techniques. (intechopen.com)
- The new technique relies on the same broad-spectrum probes previously used for ABPP, but instead of gel techniques, the team has shown that it can rapidly read experimental results by instead using a technique known as fluorescence polarization. (bio-medicine.org)
- Specific bioprobes with fluorescence turn-on response are highly desirable for high contrast biosensing and imaging. (semanticscholar.org)
Proteins2
- The scientists have developed the first widely applicable high-throughput screening technique that works even with proteins about which little is known, enabling searches for the molecules these proteins interact with, and for inhibitors that might block, the proteins' activity. (bio-medicine.org)
- While ABPP has indeed made work with uncharacterized proteins possible, one major drawback is that the technique requires laborious gel or mass spectrometry analyses to determine the results of a given experiment, such as a screen of a particular library of compounds for inhibitory activity. (bio-medicine.org)
Functionalization1
- The functionalization of nanostructured silica films for L-lactate biosensing was explored using two different enzymes. (epfl.ch)
Enzymes1
- Already, the new technique, described in the March 29, 2009 edition of the journal Nature Biotechnology , has allowed the team to identify inhibitors for two enzymes thought to play significant roles in cancer progression. (bio-medicine.org)
Advantages1
- Advantages and limitations of magnetic biosensing compared to other techniques are discussed. (fz-juelich.de)
Imaging1
- At the undergraduate level, the group is involved in Modern imaging, spectroscopy and diffraction techniques and several other courses. (chalmers.se)
Remotely1
- Understanding and designing of active and remotely powered biosensing systems. (epfl.ch)
Magnetic1
- This is because magnetic fields can be well tuned and applied either externally or from a directly integrated solution in the biosensing system. (mdpi.com)
Protein components1
- Using purified protein components and OLA, an on-chip liposome production technique that we have developed, we wish to understand, for example, blebbing motility exhibited by cells in 3D environments. (wur.nl)
Biosensor1
- This video introduces the field of biosensing, and reviews common types of biosensor technologies. (jove.com)
Mass spectrometry1
- In particular, this partnership offers the student the opportunity to study the effect of our DiP system on damage to amino acids and DNA, using HPLC and mass spectrometry complemented with other techniques such as RAMAN/FTIR. (ulster.ac.uk)
Devices1
- First, the technique can be used to test prototypes and ideas for devices and materials more quickly. (phys.org)
Chip2
- Their multi-functionality is what makes them ideal candidates as the active component in miniaturized on-chip biosensing systems. (mdpi.com)
- Specifically, they are compatible with standard silicon IC technology, and thus suitable for integration into a hand held, portable on-chip biosensing system. (mdpi.com)
High1
- New high-throughput screening technique makes probing puzzling protein. (bio-medicine.org)
Research4
- Bioinspired abiotic interfaces set the foundation for our biosensing research. (google.com)
- IJSISE provides the interface between basic research, algorithms and techniques in signal and image processing/analysis/transmission on one side and integral systems on the other. (inderscience.com)
- To nudge proteomics research forward, the Cravatt team several years ago developed a now widely used technique called Activity-Based Protein Profiling (ABPP). (bio-medicine.org)
- Her research activities include electrically small antennas, antennas in biological media, periodic structures, reflect- and tranmitarrays, and numerical techniques for electromagnetics. (epfl.ch)
Systems3
- These hybrid systems incorporate cytochrome C (CytC) as a biosensing element. (epfl.ch)
- As such, development of label-free immunodetection techniques is highly desired to reduce the cost of detection systems as well as to simplify cancer screening procedures. (spiedigitallibrary.org)
- Currently, there are a wide variety of biosensing systems that could fall under the banner of functional. (nap.edu)
Conventional2
- Conventional techniques are time-consuming and labour-intensive, and require special facilities and expensive laboratory instruments. (medicalnewstoday.com)
- With the proposed subsampling filtering technique, the subsampling mixer in a conventional DTR is eliminated, which can reduce power, cost and noise. (digchip.com)