Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.
The discarding or destroying of liquid waste products or their transformation into something useful or innocuous.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Methods for cultivation of cells, usually on a large-scale, in a closed system for the purpose of producing cells or cellular products to harvest.
Methods for maintaining or growing CELLS in vitro.
Testing for the amount of biodegradable organic material in a water sample by measuring the quantity of oxygen consumed by biodegradation of those materials over a specific time period.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Devices for simulating the activities of the liver. They often consist of a hybrid between both biological and artificial materials.
Contaminated water generated as a waste product of human activity.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
The study, utilization, and manipulation of those microorganisms capable of economically producing desirable substances or changes in substances, and the control of undesirable microorganisms.
Condition under normal Earth gravity where the force of gravity itself is not actually altered but its influence or effect may be modified and studied. (From ASGSB Bull 1992;5(2):27)
A group of different species of microorganisms that act together as a community.
Refuse liquid or waste matter carried off by sewers.
The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Any of several processes in which undesirable impurities in water are removed or neutralized; for example, chlorination, filtration, primary treatment, ion exchange, and distillation. It includes treatment of WASTE WATER to provide potable and hygienic water in a controlled or closed environment as well as provision of public drinking water supplies.
A gram-negative, facultatively chemoautotrophic bacterium, formerly called Wautersia eutropha, found in water and soil.
A family of gram-negative aerobic bacteria in the class BETA PROTEOBACTERIA, encompassing the acidovorans rRNA complex. Some species are pathogenic for PLANTS.
Apparatus, devices, or supplies intended for one-time or temporary use.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
A biocompatible polymer used as a surgical suture material.
Total mass of all the organisms of a given type and/or in a given area. (From Concise Dictionary of Biology, 1990) It includes the yield of vegetative mass produced from any given crop.
Methods of creating machines and devices.
A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A technique for maintaining or growing TISSUE in vitro, usually by DIFFUSION, perifusion, or PERFUSION. The tissue is cultured directly after removal from the host without being dispersed for cell culture.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.
The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.
The recording of images in three-dimensional form on a photographic film by exposing it to a laser beam reflected from the object under study.
A plant genus of the family APOCYNACEAE. It is a very poisonous plant that contains cardioactive agents.
Materials in intermediate state between solid and liquid.
Silicone polymers which consist of silicon atoms substituted with methyl groups and linked by oxygen atoms. They comprise a series of biocompatible materials used as liquids, gels or solids; as film for artificial membranes, gels for implants, and liquids for drug vehicles; and as antifoaming agents.
Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).
Discussions, descriptions or catalogs of public displays or items representative of a given subject.
Prohibition against tobacco smoking in specific areas to control TOBACCO SMOKE POLLUTION.
Endoscopes for examining the pleural cavity.
An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae.
Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.
Transmission of live or pre-recorded audio or video content via connection or download from the INTERNET.
Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)
The science which utilizes psychologic principles to derive more effective means in dealing with practical problems.
Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.

Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum. (1/1439)

We examined the effectiveness of antisense RNA (as RNA) strategies for metabolic engineering of Clostridium acetobutylicum. Strain ATCC 824(pRD4) was developed to produce a 102-nucleotide asRNA with 87% complementarity to the butyrate kinase (BK) gene. Strain ATCC 824(pRD4) exhibited 85 to 90% lower BK and acetate kinase specific activities than the control strain. Strain ATCC 824(pRD4) also exhibited 45 to 50% lower phosphotransbutyrylase (PTB) and phosphotransacetylase specific activities than the control strain. This strain exhibited earlier induction of solventogenesis, which resulted in 50 and 35% higher final concentrations of acetone and butanol, respectively, than the concentrations in the control. Strain ATCC 824(pRD1) was developed to putatively produce a 698-nucleotide asRNA with 96% complementarity to the PTB gene. Strain ATCC 824(pRD1) exhibited 70 and 80% lower PTB and BK activities, respectively, than the control exhibited. It also exhibited 300% higher levels of a lactate dehydrogenase activity than the control exhibited. The growth yields of ATCC 824(pRD1) were 28% less than the growth yields of the control. While the levels of acids were not affected in ATCC 824(pRD1) fermentations, the acetone and butanol concentrations were 96 and 75% lower, respectively, than the concentrations in the control fermentations. The lower level of solvent production by ATCC 824(pRD1) was compensated for by approximately 100-fold higher levels of lactate production. The lack of any significant impact on butyrate formation fluxes by the lower PTB and BK levels suggests that butyrate formation fluxes are not controlled by the levels of the butyrate formation enzymes.  (+info)

Steady-state nitrogen isotope effects of N2 and N2O production in Paracoccus denitrificans. (2/1439)

Nitrogen stable-isotope compositions (delta15N) can help track denitrification and N2O production in the environment, as can knowledge of the isotopic discrimination, or isotope effect, inherent to denitrification. However, the isotope effects associated with denitrification as a function of dissolved-oxygen concentration and their influence on the isotopic composition of N2O are not known. We developed a simple steady-state reactor to allow the measurement of denitrification isotope effects in Paracoccus denitrificans. With [dO2] between 0 and 1.2 microM, the N stable-isotope effects of NO3- and N2O reduction were constant at 28.6 per thousand +/- 1.9 per thousand and 12.9 per thousand +/- 2.6 per thousand, respectively (mean +/- standard error, n = 5). This estimate of the isotope effect of N2O reduction is the first in an axenic denitrifying culture and places the delta15N of denitrification-produced N2O midway between those of the nitrogenous oxide substrates and the product N2 in steady-state systems. Application of both isotope effects to N2O cycling studies is discussed.  (+info)

Immobilization patterns and dynamics of acetate-utilizing methanogens immobilized in sterile granular sludge in upflow anaerobic sludge blanket reactors. (3/1439)

Sterile granular sludge was inoculated with either Methanosarcina mazeii S-6, Methanosaeta concilii GP-6, or both species in acetate-fed upflow anaerobic sludge blanket (UASB) reactors to investigate the immobilization patterns and dynamics of aceticlastic methanogens in granular sludge. After several months of reactor operation, the methanogens were immobilized, either separately or together. The fastest immobilization was observed in the reactor containing M. mazeii S-6. The highest effluent concentration of acetate was observed in the reactor with only M. mazeii S-6 immobilized, while the lowest effluent concentration of acetate was observed in the reactor where both types of methanogens were immobilized together. No changes were observed in the kinetic parameters (Ks and mumax) of immobilized M. concilii GP-6 or M. mazeii S-6 compared with suspended cultures, indicating that immobilization does not affect the growth kinetics of these methanogens. An enzyme-linked immunosorbent assay using polyclonal antibodies against either M. concilii GP-6 or M. mazeii S-6 showed significant variations in the two methanogenic populations in the different reactors. Polyclonal antibodies were further used to study the spatial distribution of the two methanogens. M. concilii GP-6 was immobilized only on existing support material without any specific pattern. M. mazeii S-6, however, showed a different immobilization pattern: large clumps were formed when the concentration of acetate was high, but where the acetate concentration was low this strain was immobilized on support material as single cells or small clumps. The data clearly show that the two aceticlastic methanogens immobilize differently in UASB systems, depending on the conditions found throughout the UASB reactor.  (+info)

The role of benzoate in anaerobic degradation of terephthalate. (4/1439)

The effects of acetate, benzoate, and periods without substrate on the anaerobic degradation of terephthalate (1, 4-benzene-dicarboxylate) by a syntrophic methanogenic culture were studied. The culture had been enriched on terephthalate and was capable of benzoate degradation without a lag phase. When incubated with a mixture of benzoate and terephthalate, subsequent degradation with preference for benzoate was observed. Both benzoate and acetate inhibited the anaerobic degradation of terephthalate. The observed inhibition is partially irreversible, resulting in a decrease (or even a complete loss) of the terephthalate-degrading activity after complete degradation of benzoate or acetate. Irreversible inhibition was characteristic for terephthalate degradation only because the inhibition of benzoate degradation by acetate could well be described by reversible noncompetitive product inhibition. Terephthalate degradation was furthermore irreversibly inhibited by periods without substrate of only a few hours. The inhibition of terephthalate degradation due to periods without substrate could be overcome through incubation of the culture with a mixture of benzoate and terephthalate. In this case no influence of a period without substrate was observed. Based on these observations it is postulated that decarboxylation of terephthalate, resulting in the formation of benzoate, is strictly dependent on the concomitant fermentation of benzoate. In the presence of higher concentrations of benzoate, however, benzoate is the favored substrate over terephthalate, and the culture loses its ability to degrade terephthalate. In order to overcome the inhibition of terephthalate degradation by benzoate and acetate, a two-stage reactor system is suggested for the treatment of wastewater generated during terephthalic acid production.  (+info)

Identification of a novel group of bacteria in sludge from a deteriorated biological phosphorus removal reactor. (5/1439)

The microbial diversity of a deteriorated biological phosphorus removal reactor was investigated by methods not requiring direct cultivation. The reactor was fed with media containing acetate and high levels of phosphate (P/C weight ratio, 8:100) but failed to completely remove phosphate in the effluent and showed very limited biological phosphorus removal activity. Denaturing gradient gel electrophoresis (DGGE) of PCR-amplified 16S ribosomal DNA was used to investigate the bacterial diversity. Up to 11 DGGE bands representing at least 11 different sequence types were observed; DNA from the 6 most dominant of these bands was further isolated and sequenced. Comparative phylogenetic analysis of the partial 16S rRNA sequences suggested that one sequence type was affiliated with the alpha subclass of the Proteobacteria, one was associated with the Legionella group of the gamma subclass of the Proteobacteria, and the remaining four formed a novel group of the gamma subclass of the Proteobacteria with no close relationship to any previously described species. The novel group represented approximately 75% of the PCR-amplified DNA, based on the DGGE band intensities. Two oligonucleotide rRNA probes for this novel group were designed and used in a whole-cell hybridization analysis to investigate the abundance of this novel group in situ. The bacteria were coccoid and 3 to 4 microm in diameter and represented approximately 35% of the total population, suggesting a relatively close agreement with the results obtained by the PCR-based DGGE method. Further, based on electron microscopy and standard staining microscopic analysis, this novel group was able to accumulate granule inclusions, possibly consisting of polyhydroxyalkanoate, inside the cells.  (+info)

Fluorescence in situ hybridization using 16S rRNA-targeted oligonucleotides reveals localization of methanogens and selected uncultured bacteria in mesophilic and thermophilic sludge granules. (6/1439)

16S rRNA-targeted in situ hybridization combined with confocal laser scanning microscopy was used to elucidate the spatial distribution of microbes within two types of methanogenic granular sludge, mesophilic (35 degrees C) and thermophilic (55 degrees C), in upflow anaerobic sludge blanket reactors fed with sucrose-, acetate-, and propionate-based artificial wastewater. The spatial organization of the microbes was visualized in thin sections of the granules by using fluorescent oligonucleotide probes specific to several phylogenetic groups of microbes. In situ hybridization with archaeal- and bacterial-domain probes within granule sections clearly showed that both mesophilic and thermophilic granules had layered structures and that the outer layer harbored mainly bacterial cells while the inner layer consisted mainly of archaeal cells. Methanosaeta-, Methanobacterium-, Methanospirillum-, and Methanosarcina-like cells were detected with oligonucleotide probes specific for the different groups of methanogens, and they were found to be localized inside the granules, in both types of which dominant methanogens were members of the genus Methanosaeta. For specific detection of bacteria which were previously detected by whole-microbial-community 16S ribosomal DNA (rDNA)-cloning analysis (Y. Sekiguchi, Y. Kamagata, K. Syutsubo, A. Ohashi, H. Harada, and K. Nakamura, Microbiology 144:2655-2665, 1998) we designed probes specific for clonal 16S rDNAs related to unidentified green nonsulfur bacteria and clones related to Syntrophobacter species. The probe designed for the cluster closely related to Syntrophobacter species hybridized with coccoid cells in the inner layer of the mesophilic granule sections. The probe for the unidentified bacteria which were clustered with the green nonsulfur bacteria detected filamentous cells in the outermost layer of the thermophilic sludge granule sections. These results revealed the spatial organizations of methanogens and uncultivated bacteria and their in situ morphologies and metabolic functions in both mesophilic and thermophilic granular sludges.  (+info)

High-rate anaerobic treatment of wastewater at low temperatures. (7/1439)

Anaerobic treatment of a volatile fatty acid (VFA) mixture was investigated under psychrophilic (3 to 8 degrees C) conditions in two laboratory-scale expanded granular sludge bed reactor stages in series. The reactor system was seeded with mesophilic methanogenic granular sludge and fed with a mixture of VFAs. Good removal of fatty acids was achieved in the two-stage system. Relative high levels of propionate were present in the effluent of the first stage, but propionate was efficiently removed in the second stage, where a low hydrogen partial pressure and a low acetate concentration were advantageous for propionate oxidation. The specific VFA-degrading activities of the sludge in each of the modules doubled during system operation for 150 days, indicating a good enrichment of methanogens and proton-reducing acetogenic bacteria at such low temperatures. The specific degradation rates of butyrate, propionate, and the VFA mixture amounted to 0.139, 0.110, and 0.214 g of chemical oxygen demand g of volatile suspended solids-1 day-1, respectively. The biomass which was obtained after 1.5 years still had a temperature optimum of between 30 and 40 degrees C.  (+info)

Functional arteries grown in vitro. (8/1439)

A tissue engineering approach was developed to produce arbitrary lengths of vascular graft material from smooth muscle and endothelial cells that were derived from a biopsy of vascular tissue. Bovine vessels cultured under pulsatile conditions had rupture strengths greater than 2000 millimeters of mercury, suture retention strengths of up to 90 grams, and collagen contents of up to 50 percent. Cultured vessels also showed contractile responses to pharmacological agents and contained smooth muscle cells that displayed markers of differentiation such as calponin and myosin heavy chains. Tissue-engineered arteries were implanted in miniature swine, with patency documented up to 24 days by digital angiography.  (+info)

Global Perfusion Bioreactors Sales Market Report 2017 1 Perfusion Bioreactors Market Overview 1.1 Product Overview and Scope of Perfusion Bioreactors 1.2 Classification of Perfusion Bioreactors by Product Category 1.2.1 Global Perfusion Bioreactors Market Size (Sales) Comparison by Type (2012-2022) 1.2.2 Global Perfusion Bioreactors Market Size (Sales) Market Share by Type (Product Category) in 2016 1.2.3 Small Scale(50 Liters to 1,000 Liters) 1.2.4 Large Scale(>1,000 Liters) 1.3 Global Perfusion Bioreactors Market by Application/End Users 1.3.1 Global Perfusion Bioreactors Sales (Volume) and Market Share Comparison by Application (2012-2022) 1.3.2 Biopharmaceutical Companies 1.3.3 Biotechnology Companies 1.3.4 Others 1.4 Global Perfusion Bioreactors Market by Region 1.4.1 Global Perfusion Bioreactors Market Size (Value) Comparison by Region (2012-2022) 1.4.2 United States Perfusion Bioreactors Status and Prospect (2012-2022) 1.4.3 China Perfusion Bioreactors Status and Prospect (2012-2022) ...
The report on the Global Membrane Bioreactor Systems market offers complete data on the Membrane Bioreactor Systems market. Components, for example, main players, analysis, size, situation of the business, SWOT analysis, and best patterns in the market are included in the report. In addition to this, the report sports numbers, tables, and charts that offer a clear viewpoint of the Membrane Bioreactor Systems market. The top contenders GE Water, Veolia Water Solutions & Technologies, Koch Membrane Systems, Hitachi Aqua-Tech Engineering, Mitsubishi Rayon, Wehrle Umwelt GmbH, Degremont(SUEZ), Kubota, United Envirotech, WesTech Engineering, Bio-Microbics, Ovivo, Aqua-Aerobic Systems, Evac, Toray, Evoqua Water Technologies, Beijing Grant Membrane Separation Equipment of the global Membrane Bioreactor Systems market are further covered in the report .. Access to the sample pages of the report at: http://www.extentresearch.com/request-for-sample.html?repid=20111. The report also segments the global ...
Title:In Vitro Osteogenesis of Human Stem Cells by Using a Three-Dimensional Perfusion Bioreactor Culture System: A Review. VOLUME: 7 ISSUE: 1. Author(s):Gabriele Ceccarelli, Nora Bloise, Marco Vercellino, Rosalia Battaglia, Lucia Morgante, Maria Gabriella Cusella De Angelis, Marcello Imbriani and Livia Visai. Affiliation:Dep. of Molecular Medicine, University of Pavia, Viale Taramelli 3/B, 27100 Pavia, Italy.. Keywords:Biomaterials, extracellular matrix, induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSC), osteogenesis, perfusion bioreactor, scaffolds, tissue engineering. Abstract:Tissue engineering (by culturing cells on appropriate scaffolds, and using bioreactors to drive the correct bone structure formation) is an attractive alternative to bone grafting or implantation of bone substitutes. Osteogenesis is a biological process that involves many molecular intracellular pathways organized to optimize bone modeling. The use of bioreactor systems and especially the perfusion ...
Fixed thin film, gas/vapor phase bioreactors were assessed relative to their potential for the bioprocessing of methane, trichloroethylene (TCE), and p-xylene. Methanotrophic bacteria were used to process the methane and TCE while a xylene resistant strain of Pseudomonas putida was used to process the p-xylene. Comparisons between the gas phase bioreactors and conventional shaken cultures and sparged liquid bioreactors showed that the gas phase bioreactors offer advantages over the other two systems for the degradation of methane in air. Rates of methane removal with the gas phase bioreactors were 2.1 and 1.6 fold greater than those exhibited by the shaken cultures and sparged liquid bioreactors, respectively. The gas phase bioreactors were shown to have application for the removal of TCE vapors from air with a removal rate of approximately 9 μg TCE d-1 bioreactor-1. Xylene vapors were also scrubbed from air using gas phase bioreactors. At a feed rate of 140 μg of xylene min-1, approximately ...
TY - JOUR. T1 - Bioreactor design for protein enrichment of agricultural residues by solid state fermentation. AU - Robinson, T. AU - Singh - Nee Nigam, Poonam. PY - 2003/3. Y1 - 2003/3. N2 - This paper reviews bioreactor designs and their use for protein production under solid state fermentation (SSF) conditions using various agricultural by-products. The advantages and disadvantages of various bioreactors and their potential for scale-up are described. SSF is proposed as a suitable low-tech strategy for protein enrichment for animal feed by converting a previously low value substance into a more nutritionally valuable one. The use of various substrates and microorganisms for protein enrichment are also listed. (C) 2002 Elsevier Science B.V. All rights reserved.. AB - This paper reviews bioreactor designs and their use for protein production under solid state fermentation (SSF) conditions using various agricultural by-products. The advantages and disadvantages of various bioreactors and their ...
During the past decade, single-use bioreactors have become widely accepted as an alternative to conventional stainless steel or glass bioreactors for clinical manufacturing and process development. In the biopharmaceutical industry, glass bioreactors are used mainly for process development and optimization, but also scale-down models for process characterization. So it is of significant importance that such vessels replicate the design of production-scale bioreactors for both reusable and single-use applications. Stirred-tank bioreactors with 2-L, 5-L, and 10-L working volumes have proven to…. ...
Adipose tissue engineering holds promise to address the unmet need in plastic and reconstructive surgery for strategies that promote the stable and predictable regeneration of adipose tissue for volume augmentation applications. Previous studies have demonstrated that decellularized adipose tissue (DAT) scaffolds can provide a pro-adipogenic microenvironment, and that seeding with adipose-derived stromal cells (ASCs) can enhance in vivo angiogenesis and adipogenesis within DAT implants. Recognizing that bioreactor systems can promote cell expansion and infiltration on tissue-engineered scaffolds, this study evaluated the effects of culturing human ASCs on DAT scaffolds within a perfusion bioreactor. Using this system, the impact of both shear stress stimulation and hypoxic preconditioning were explored in vitro and in vivo. Initial studies compared the effects of 14 days of culture within the perfusion bioreactor under 2% O2 or ~20% O2 on human ASC expansion and hypoxic inducible factor 1 alpha ...
The amblr® 250 modular bioreactor system is an expandable benchtop workstation, which offers a simple approach to process development for fermentation and cell culture.. Sartorius Stedim Biotech (SSB) introduced the ambr® 250 modular to offer bioprocess scientists access to advanced benchtop bioreactor technology for process development. This system combines a unique single-use bioreactor vessel and consists of a workstation with 2, 4, 6, or 8 single-use bioreactors, with a working volume range of 100mL to 250mL.. These mini bioreactors are based on the same stirred tank bioreactors in the well-established ambr® 250 high-throughput system and contain impellers suitable for fermentation or cell culture. They are also fully integrated with liquid reservoirs and syringe pumps, allowing rapid experimental set up and turn around, significantly increasing lab efficiency.. The system brings simplicity to the lab bench. By following three easy steps, a bioreactor and all required accessories can be ...
In one aspect, the inventive process comprises a process for pyrolyzing a hydrocarbon feedstock containing nonvolatiles in a regenerative pyrolysis reactor system. The inventive process comprises: (a) heating the nonvolatile-containing hydrocarbon feedstock upstream of a regenerative pyrolysis reactor system to a temperature sufficient to form a vapor phase that is essentially free of nonvolatiles and a liquid phase containing the nonvolatiles; (b) separating said vapor phase from said liquid phase; (c) feeding the separated vapor phase to the pyrolysis reactor system; and (d) converting the separated vapor phase in said pyrolysis reactor system to form a pyrolysis product.
Biological treatment of dairy wastewater was investigated using a laboratory scale aerobic sequencing batch flexible fibre biofilm reactor (SBFFBR). The SBFFBR system was modified from a typical sequencing batch reactor system by using eight flexible fibre bundles with a very high specific surface area, which served as support for microorganisms. The reactor was operated under different influent chemical oxygen demand (COD) concentrations (610, 2041 and 4382 mg l-1) and constant hydraulic retention times of 1.6 days. The results have shown successful applicability of the SBFFBR system to treat this dairy wastewater. High COD removal efficiencies between 89.7 and 97% were achieved at average organic loading rates of 0.4 and 2.74 kg COD m-3 d-1, respectively ...
Orbitally shaken bioreactors (OSRs) support the suspension cultivation of animal cells at volumetric scales up to 200 L and are a potential alternative to stirred-tank bioreactors (STRs) due to their rapid and homogeneous mixing and high oxygen transfer rate. In this study, a Chinese hamster ovary cell line producing a recombinant antibody was cultivated in a 5L OSR and a 3L STR, both operated with or without pH control. Effects of bioreactor type and pH control on cell growth and metabolism and on recombinant protein production and glycosylation were determined. In pH-controlled bioreactors, the glucose consumption and lactate production rates were higher relative to cultures grown in bioreactors without pH control. The cell density and viability were higher in the OSRs than in the STRs, either with or without pH control. Volumetric recombinant antibody yields were not affected by the process conditions, and a glycan analysis of the antibody by mass spectrometry did not reveal major ...
SAF ENGINEERS - Exporter and Manufacturer of Membrane Bioreactor Systems in Khureji, Delhi, Delhi, India. Get deals on Membrane Bioreactor Systems at Tradeindia.
Membrane Bioreactor Systems Market - by Types [Hollow Fiber, Flat Sheet, Multi Tubular], Configuration [Internal (Submerged/Immersed) & External (Sidestream)] & Applications [Municipal & Industrial Wastewater Treatment] - Trends & Forecasts to 2017 new market research report added to ReportsnReports.com store.. Dallas, Texas (PRWEB) December 30, 2012 This report Membrane Bioreactor (MBR) Systems Market, By Application (Municipal & Industrial), Type (Hollow Fiber, Flat Sheet & Multi Tubular) & Configuration (Submerged & Sidestream) - Global Trends & Forecasts to 2017 analyses the Membrane bioreactor (MBR) market by geography, applications, configurations, and types of MBR. By geography, the report is segmented into Asia-Pacific, Europe, North America, and Rest of the World. The MBR type segment included in this report is based on design of the membrane, i.e. hollow fiber, flat sheet, and multi tubular. The end-users of this technology are spread across various industries - food & beverage, ...
Woodchip bioreactors are recognized as an effective best management practice in the Iowa Nutrient Reduction Strategy. This edge-of-field practice intercepts and removes NO₃-N, thereby reducing the NO₃-N concentration in tile drainage before being discharged into surface water. Actual NO₃-N load reductions realized by woodchip bioreactors are impacted by bioreactor size, hydraulic retention time (H ...
TY - JOUR. T1 - Optimizing the medium perfusion rate in bone tissue engineering bioreactors. AU - Grayson, Warren L. AU - Marolt, Darja. AU - Bhumiratana, Sarindr. AU - Fröhlich, Mirjam. AU - Guo, X. Edward. AU - Vunjak-Novakovic, Gordana. PY - 2011/5. Y1 - 2011/5. N2 - There is a critical need to increase the size of bone grafts that can be cultured in vitro for use in regenerative medicine. Perfusion bioreactors have been used to improve the nutrient and gas transfer capabilities and reduce the size limitations inherent to static culture, as well as to modulate cellular responses by hydrodynamic shear. Our aim was to understand the effects of medium flow velocity on cellular phenotype and the formation of bone-like tissues in three-dimensional engineered constructs. We utilized custom-designed perfusion bioreactors to culture bone constructs for 5 weeks using a wide range of superficial flow velocities (80, 400, 800, 1,200, and 1,800μm/s), corresponding to estimated initial shear stresses ...
The worldwide Bioreactors Market is anticipated to generate revenues over USD 550 million by 2024. It will grow at a CAGR above 18% in the forecast period (2016-2024). The industry is driven by the demand for biologics and adoption of single-use bioreactors (SUBs) & hybrid bioreactors. Rising popularity of SUBs in pharmaceutical manufacturing companies is yet another key driver.. SUBs or disposable bioreactors contain disposable bags instead of cultural vessels. They face high demand from the medical sector. These reactors are adopted by pharmaceutical companies to manufacture drugs without any negotiations on their quality. These systems differ in view of flexibility and cultural medium. Commercial bioreactors include CellMarket Regular from Cellexus and HyClone SUB from Thermo Fisher Scientific.. Browse Details of Report @ https://www.hexaresearch.com/research-report/bioreactors-market. Low functional costs of SUBs and low maintenance required for them can propel market demand from 2016 to ...
The worldwide Bioreactors Market is anticipated to generate revenues over USD 550 million by 2024. It will grow at a CAGR above 18% in the forecast period (2016-2024). The industry is driven by the demand for biologics and adoption of single-use bioreactors (SUBs) & hybrid bioreactors. Rising popularity of SUBs in pharmaceutical manufacturing companies is yet another key driver.. SUBs or disposable bioreactors contain disposable bags instead of cultural vessels. They face high demand from the medical sector. These reactors are adopted by pharmaceutical companies to manufacture drugs without any negotiations on their quality. These systems differ in view of flexibility and cultural medium. Commercial bioreactors include CellMarket Regular from Cellexus and HyClone SUB from Thermo Fisher Scientific.. Browse Details of Report @ https://www.hexaresearch.com/research-report/bioreactors-market. Low functional costs of SUBs and low maintenance required for them can propel market demand from 2016 to ...
Reactor systems are provided for the catalytic conversion of liquid feedstocks to synthesis gases and other noncondensable gaseous products. The reactor systems include a heat exchange reactor configured to allow the liquid feedstock and gas product to flow concurrently in a downflow direction. The reactor systems are particularly useful for producing hydrogen and light hydrocarbons from biomass-derived oxygenated hydrocarbons using aqueous phase reforming. The generated gases may find used as a fuel source for energy generation via PEM fuel cells, solid-oxide fuel cells, internal combustion engines, or gas turbine gensets, or used in other chemical processes to produce additional products. The gaseous products may also be collected for later use or distribution.
Global Membrane Aerated Biofilm Reactor (MABR) Market offered by Market Research Outlet gives several advantages and enhances the adoption of absorption among several industrial users. The report researches the Membrane Aerated Biofilm Reactor (MABR) Market to evaluate its current and future potential. Membrane Aerated Biofilm Reactor (MABR) Market Report also describes the supply and demand situation, market landscape, and competitive scenario. The report researches the Membrane Aerated Biofilm Reactor (MABR) Market to evaluate its current and future potential.. The Global Membrane Aerated Biofilm Reactor (MABR) Market is estimated to value at nearly US$ XX Mn in 2019 and is expected to register a CAGR of XX.X%.. Download FREE Sample of this Report : https://www.marketresearchoutlet.com/report/membrane-aerated-biofilm-reactor-mabr-market-report-1/request-sample. Global Membrane Aerated Biofilm Reactor (MABR) Market competition by leading manufacturers, with production, price, and revenue ...
The physical and biochemical characteristics of the biomass in three lab-scale sequencing batch reactors (SBR) treating a synthetic wastewater at a 20-day target solids retention time (SRT) were investigated. The synthetic wastewater feed contained biogenic compounds and 22 organic priming compounds, chosen to represent a wide variety of chemical structures with different N, P and S functional groups. At a two-day hydraulic retention time (HRT), the oxidation-reduction potential (ORP) cycled between -100 (anoxic) and 100 mV (aerobic) in the anoxic/aerobic SBR, while it remained in a range of 126+/-18 and 249+/-18 mV in the aerobic sequencing batch biofilm reactor (SBBR) and the aerobic SBR reactor, respectively. A granular activated sludge with excellent settleability (SVI=98+/-31 L mg(-1)) developed only in the anoxic/aerobic SBR, compared to a bulky sludge with poor settling characteristics in the aerobic SBR and SBBR. While all reactors had very good COD removal (|90%) and displayed nitrification,
Bioreactors are integral to development of high value products and reducing reliance on existing chemical based commodity processes. The design of bioreactors for large scale production is complex process. Hydrodynamic condition in bioreactor plays a very important role in process performance and it is very important to get detailed insight into hydrodynamics for successful scale-up. Experimental testing at lab and pilot scale is both time consuming and expensive and does not always help to understand the underlying influence of reactor hardware and operating protocols on process yields.. This webinar discusses how MixIT - An Enterprise Mixing Analysis Solutions developed by Tridiagonal Solutions helps the process engineers to get more insights into hydrodynamics in bioreactors using advanced CFD based analysis.. Case studies will be demonstrated involving scale-up and troubleshooting of the bioreactors.. Who Should Attend? ...
Cell culture process development requires the screening of large numbers of cell lines and process conditions. The development of miniature bioreactor systems has increased the throughput of such studies; however, there are limitations with their use. One important constraint is the limited number of offline samples that can be taken compared to those taken for monitoring cultures in large-scale bioreactors. The small volume of miniature bioreactor cultures (15 mL) is incompatible with the large sample volume (600 µL) required for bioanalysers routinely used. Spectroscopy technologies may be used to resolve this limitation. The purpose of this study was to compare the use of NIR, Raman, and 2D-fluorescence to measure multiple analytes simultaneously in volumes suitable for daily monitoring of a miniature bioreactor system. A novel design-of-experiment approach is described that utilizes previously analyzed cell culture supernatant to assess metabolite concentrations under various conditions ...
TY - JOUR. T1 - Effects of scaffold architecture on mechanical characteristics and osteoblast response to static and perfusion bioreactor cultures. AU - Bartnikowski, Michal. AU - Klein, Travis J.. AU - Melchels, Ferry P. W.. AU - Woodruff, Maria A.. PY - 2014/7. Y1 - 2014/7. N2 - Tissue engineering focuses on the repair and regeneration of tissues through the use of biodegradable scaffold systems that structurally support regions of injury while recruiting and/or stimulating cell populations to rebuild the target tissue. Within bone tissue engineering, the effects of scaffold architecture on cellular response have not been conclusively characterized in a controlled-density environment. We present a theoretical and practical assessment of the effects of polycaprolactone (PCL) scaffold architectural modifications on mechanical and flow characteristics as well as MC3T3-E1 preosteoblast cellular response in an in vitro static plate and custom-designed perfusion bioreactor model. Four scaffold ...
Myozyme Produced at the 2000 L Bioreactor Scale to Receive Accelerated Approval Myozyme Produced at the 2000 L Bioreactor Scale to Receive Accelerated Approval Date: November 17, 2008 New PDUFA Date Set for February 28, 2009 Genzyme Corporation (Nasdaq: GENZ) today announced that the FDA plans an Accelerated Approval f
Biogas and biofertilizer production from anaerobic digestion of local organic solid waste in Algeria is an attractive choice for greener and cleaner environment. In this paper, the study focused on the effect of co-digestion of municipal solid organic wastes (MSW) and camel dung (CD) for the quality production of biogas (methane) and bio fertilizer products. The concentration of methane production is the preeminent aim of this work. The experiment was set by feedstocks preparation where organic waste was mixed with tap water at 1:1 ratio and it allowed to digest at temperature of 40 °C. The operating hydraulic retention time (HRT) was set at 35 days. Physicochemical properties of feedstocks and constituent elements of the digestate were determined by American Public Health Association methods. The experimental study indicated that underdefined operational conditions such as constant organic loading rate (OLR) of 0.6 kg per day, hydraulic retention time (HRT) of 35 days and temperature of 40C ...
Validation of a model for process development and scale-up of packed-bed solid-state bioreactors | Frans J. Weber; Jaap Oostra; Johannes Tramper; Arjen Rinzema | download | BookSC. Download books for free. Find books
Validation of a model for process development and scale-up of packed-bed solid-state bioreactors | Frans J. Weber; Jaap Oostra; Johannes Tramper; Arjen Rinzema | download | BookSC. Download books for free. Find books
This project will develop and demonstrate a prototype Modular Perfusion Bioreactor (MPB) for tissue engineering applications. While many unique styles of bioreactors have been proposed for various types of stem cell and tissue cultures, there is not a single, easy-to-use device that accommodates the multiple diverse needs of multiple tissue culture types.. In order to take advantage of recent advances in stem cell culture, biomaterials, and tissue engineering techniques, Resodyn Corporation proposes to develop, design, fabricate, and test a multi-functional bioreactor platform system. As a starting point for this multi-functional system, Resodyn Corporation will use its highly scalable (50-1,500ml) and successful (>1x108 cells/ml) hypoxia perfusion bioreactor. The focus of the proposed work will be to design additional culture modules that can be plugged into an advanced platform system developed by Resodyn Corporation. Modules that allow the culture of cellular monolayers, encapsulated cells, ...
Organic matter is the dominant pool of reduced carbon in marine and freshwater systems. Mineralization of organic matter is largely attributed to complex and diverse microbial communities that mediate degradation and ultimately yield the terminal respiratory product, carbon dioxide (CO2). The factors that constrain the lability and degradation of organic matter remain unclear, but they involve a complex interplay between structural and chemical properties of the compounds, physical properties of the matrices, and the functional potential of the microorganisms that are present. To investigate these relationships, we developed a novel bioreactor system-called Isotopic Carbon Respirometer-Bioreactor (IsoCaRB)-that permits real-time monitoring of microbial CO2 production rates and collects sequential samples of this CO2 for off-line isotopic analyses (C-13, C-14). Application of this system to organic-rich sediments from Salt Pond, MA reveals that organic matter is oxidized both abiotically and ...
Tissue engineering is an emerging field with the aim to produce artificial organs and tissues for transplant treatments. Cultivating cells on scaffolds by means of bioreactors is a critical step to forming the organ or tissue substitutes prior to transplantation. Among various bioreactors, the perfusion bioreactor is known for its enhanced convection through the cell-scaffold constructs. The enhanced convection will significantly increase the mass transport and at the same time, will increase the shear stress acting on the cells and scaffolds. To manipulate the scaffold-based cell culture process, knowledge of the mass transport and fluid flow (featured by flow velocity and shear stress) in bioreactors is required. Due to the complicated microstructure and multiphase flow involved in this process, the development of models for capturing the aforementioned knowledge has proven to be a challenging task. In this research, the mass transport and fluid flow in scaffolds cultivated in perfusion ...
DASGIP Parallel Bioreactor Systems for R&D and process development in both cell culture and microbiology allow for advanced bioprocess control and automation. Parallel processing, precise control of all relevant parameters, user-defined profiles and innumerable automation features result in accelerated and highly efficient process development. Our DASware software solutions support DoE, process historians and comprehensive data management. Configurable solutions address the unique requirements of microbial, phototrophic, mammalian and human cells, stem cell applications, as well as biofuel and biopolymer processes.. ...
Avid Bioservices is a dedicated contract development and manufacturing organization (CDMO) focused on development and CGMP manufacturing of biopharmaceutical drug substances derived from mammalian cell culture. The company provides a comprehensive range of process development, CGMP clinical and commercial manufacturing services for the biotechnology and biopharmaceutical industries. With 27 years of experience producing monoclonal antibodies and recombinant proteins, Avids services include CGMP clinical and commercial drug substance manufacturing, bulk packaging, release and stability testing and regulatory submissions support. For early-stage programs the company provides a variety of process development activities, including upstream and downstream development and optimization, analytical methods development, testing and characterization. The scope of our services ranges from standalone process development projects to full development and manufacturing programs through commercialization. ...
Each bioreactor is equipped with a process stand for ensuring the automated fermentation, cleaning, sterilization, heating and cooling processes. Each bioreactor container and process stand is equipped with pneumatic elements, mixer, circulation pump and peristaltic pumps. The bioreactors have in-built рН, рО2, temperature, maximum liquid level, foam level and pressure sensors. All sensors and control elements are connected to a corresponding bioreactor control local system, where the local control is performed from a color touch screen display (with a 7 or 9.6). In the given example, the bioreactor control systems have Siemens Simatic controllers.. Thus the local control of each particular bioreactor was ensured independently from the rest bioreactors. The central cascade control system (CCCS) ensured interconnection between different bioreactors and the CIP/SIP system, as well as with the computerized SCADA system. For this purpose a more powerful Siemens Simatic controller was used in ...
IKAs innovative laboratory reactor systems are modular solutions that have been developed to assist in the optimisation and reproduction of laboratory-level chemical reaction, mixing, dispersal and homogenising activities.. The reactor systems can be adapted individually to a wide range of tasks. This includes, and is not limited to, the manufacture of creams and lotions, the grinding and reduction to fibres of solids in liquids or polymers, and the mixing and drying of powders.. Single-walled or double-walled vessels made from borosilicate glass or stainless steel are available, either with or without a bottom discharge valve.. LR 1000 basic control. The LR 1000 basic is an entry-level modular laboratory reactor designed for optimising chemical reaction processes and mixing, dispersing and homogenisation applications.. The reactor is especially designed for the unique application requirements on a laboratory scale that define the cosmetic and pharmaceutical industries.. The temperature of the ...
This study used vertical and horizontal subsurface constructed wetlands with continuous inflow, to compare and analyze the effects of four hydraulic residence times on the removal efficiency of conventional pollutants. Using the optimal hydraulic retention time, the two types of wetlands were examined in terms of the stromal layer nitrification, denitrification, and ammonia oxidation abundance of functional genes, as well as the intensity of nitrification and denitrification. In addition, redundancy analysis and variance decomposition analysis were used to determine the main factors affecting nitrogen removal in the two kinds of wetlands, so that targeted improvement measures can be suggested. The best removal efficiency of conventional pollutants (COD, TP, TN, and NH4+-N) was achieved with a hydraulic retention time of 24 h, resulting in a removal rate of more than 70%. With a 24 h retention time, the removal rate of NH4+-N and TN and the intensity of nitrification and denitrification exhibited ...
Fine bubble oxygen transfer efficiencies fluctuated throughout the study. A nitrifying aeration system, operated at an 8-day sludge age, exhibited significantly higher αF values compared with a nonnitrifying system operated at a 2-day sludge age. Differences in organic loading, over the range investigated (0.50 to 1.2 kg biochemical oxygen demand [BOD]5/m3·d), did not show an effect on fine bubble αF performance. At a short sludge age (2 days) and a high volumetric organic loading rate, a pilot system operated at a higher recycle rate (100% versus 33%) exhibited improved aF values. The addition of either an aerobic or an anoxic upstream biological selector (13-minute hydraulic retention time) improved ceramic diffuser oxygen transfer performance at high volumetric organic loading rates ...
http://www.marketsandmarkets.com/Market-Reports/membrane-bioreactor-market-484.html. This market research report categorizes the MBR into submarkets on the basis of types, configurations, and application sectors. The report covers all the major types of MBR, i.e. hollow fiber, flat sheet, and multi tubular. The membrane bioreactor system combines filtration technology with biological treatment for municipal and industrial waste water treatment and water reuse applications. The system incorporates reinforced hollow fiber, flat sheet or multi tubular membranes specifically designed to meet the requirements of wastewater treatment.. The report  defines and segments the global MBR demand market with analysis and forecasting of the global volume (000 cubic meter/day for main regions) and revenue ($million for all segments) for MBRs. The market is segmented and forecasted on the basis of major regions such as North America, Europe, Asia-Pacific, and Rest of the World. The key countries are ...
How is Sequencing Batch Biofilm Reactor abbreviated? SBBR stands for Sequencing Batch Biofilm Reactor. SBBR is defined as Sequencing Batch Biofilm Reactor somewhat frequently.
MarketResearchReports.Biz presents this most up-to-date research on Global Membrane Bioreactor Systems Market Professional Survey Report 2017 Description
McFetridge, P. S., Abe, K., Horrocks, M. and Chaudhuri, J. B., 2007. Vascular tissue engineering: Bioreactor design considerations for extended culture of primary human vascular smooth muscle cells. Asaio Journal, 53 Sep-Oct (5), pp. 623-630.. ...
DASGIP Parallel Bioreactor Systems for R&D and process development in both cell culture and microbiology allow for advanced bioprocess control and automation. Parallel processing, precise control of all relevant parameters, user-defined profiles and innumerable automation features result in accelerated and highly efficient process development. Our DASware software solutions support DoE, process historians and comprehensive data management. Configurable solutions address the unique requirements of microbial, phototrophic, mammalian and human cells, stem cell applications, as well as biofuel and biopolymer processes.. ...
This study investigated the use of biological powdered activated carbon (PAC) for the removal of natural organic matter (NOM) and ammonia from drinking water. The impact of solids retention time (SRT), hydraulic retention time (HRT), PAC diameter and PAC concentration on the process efficiency was evaluated. Five bioreactors were filled with a slurry using two PAC concentrations (5 or 25 g l−1), two PAC mean diameters (25 or 200 μm) and two SRTs (30 or 100-160 days). The bioreactors were operated during 161 days using post-ozonated water as influent. It was determined that the PAC concentration in the bioreactors was a key parameter for the improvement of biological removal. The higher PAC concentration (25 g l−1) was more efficient for the removal of ammonia, dissolved organic carbon (DOC) and biodegradable dissolved organic carbon (BDOC). Full nitrification was observed after 90 days in bioreactors with 25 g l− of PAC. The PAC diameter (25 vs. 200 μm) did not significantly influence ...
Both aerobic and anaerobic membrane bioreactors (MBRs) are able to remove contaminants of emerging concern from wastewater at high efficiencies. However, the main bottleneck of this technology is membrane biofouling. Coating heavy metal nanoparticles on the surface of membrane has been proposed as an effective antifouling strategy. Nevertheless, metal nanoparticles can potentially result in detrimental impact on the overall functionality of the MBRs. This book chapter aims to understand how nanoparticles impact MBRs. To achieve this aim, the chapter starts off by illustrating the antibacterial mechanisms of nanoparticles. The chapter then critically reviews past studies that illustrate the antibacterial effect of nanoparticles against pure bacterial cultures and biofilm-associated populations. Finally, the chapter evaluates if the presence of nanoparticles would affect the overall performance of aerobic and anaerobic biological processes. Specifically, the impact of heavy metal nanoparticles on ...
Anaerobic reactors with ferric iron addition have been experimentally demonstrated to be able to simultaneously improve sulfate reduction and organic matter degradation during sulfate-containing wastewater treatment. In this work, a mathematical model is developed to evaluate the impact of ferric iron addition on sulfate reduction and organic carbon removal as well as the volatile fatty acids (VFA) composition in anaerobic reactor. The model is successfully calibrated and validated using independent long-term experimental data sets from the anaerobic reactor with Fe (III) addition under different operational conditions. The model satisfactorily describes the sulfate reduction, organic carbon removal and VFA production. Results show Fe (III) addition induces the microbial reduction of Fe (III) by iron reducing bacteria (IRB), which significantly enhances sulfate reduction by sulfate reducing bacteria (SRB) and subsequently changes the VFA composition to acetate-dominating effluent. ...
Human mesenchymal stem cells (hMSC) are a promising cell source for the manufacturing of cell therapeutic or tissue engineered implants. In part A of this publication a fixed-bed bioreactor system based on non-porous borosilicate glass spheres and procedures for the automated expansion of hMSC with high yield and vitality has been introduced. Part B of this study deals with the modeling of the process in order to transfer the bioreactors system from the laboratory to the production scale. Relevant model parameters have been obtained by fitting them to the experimental data of hMSC-TERT cultivations in scales up to 300 cm3. Scale-up calculations were carried out exemplarily for a target cell number of twenty billion cells ...
The new Corning Mini Bioreactors are ideal for high throughput process optimization for suspension cell culture. Consisting of a 50mL centrifuge polyprene tube with a vented cap, Corning Mini Bioreactors are sterile, nonpyrogenic, RNase-/DNase-free and are suitable for cell line development, clone selection, media optimization and recombinant protein development.
Wood chip bioreactors are simple trenches that can be constructed on farms to clean the water that flows out of tile drains. Although the bioreactors are already a proven practice, more work remains to be done.
Described in this poster is how to convert existing glass benchtop bioreactors to single use bioreactors with minimal capital investment.
TY - JOUR. T1 - Effect of NaCl on nitrate removal from ion-exchange spent brine in the membrane biofilm reactor (MBfR). AU - Van Ginkel, Steven W.. AU - Kim, Bi O.. AU - Yang, Ziming. AU - Sittmann, Robby. AU - Sholin, Mark. AU - Micelli, Joe. AU - Rittmann, Bruce. PY - 2012/1/20. Y1 - 2012/1/20. N2 - The H 2-based membrane biofilm reactor was used to remove nitrate from synthetic ion-exchange brine at NaCl concentrations from ∼3 to 30 g/L. NaCl concentrations below 20 g/L did not affect the nitrate removal flux as long as potassium was available to generate osmotic tolerance for high sodium, the H 2 pressure was adequate, and membrane fouling was eliminated. Operating pHs of 7-8 and periodic citric acid washes controlled membrane fouling and enabled reactor operation for 650 days. At 30 psig H 2 and high nitrate loading rates of 15 to 80 g/m 2 d, nitrate removal fluxes ranged from 2.5 to ∼6 g/m 2 d, which are the highest fluxes observed when treating 30 g/L IX brine. However, percent ...
The following chapter summarizes principles of fluid dynamics in bioreactor design with a focus on mammalian cell-culture systems.
Bioreactor design issues[edit]. *Restriction of photosynthetic hydrogen production by accumulation of a proton gradient. ...
Porous Substrate Bioreactor (PSBR), being developed at University of Cologne, also known as the twin-layer system, uses a new ... A photobioreactor (PBR) is a bioreactor that utilizes a light source to cultivate phototrophic microorganisms. These organisms ... "Current achievements in the production of complex biopharmaceuticals with moss bioreactors". Bioprocess and Biosystems ...
... bioreactors may be followed by a physical phase separation to remove biological solids from the treated ... Membrane bioreactors (MBR) are activated sludge systems using a membrane liquid-solid phase separation process. The membrane ... The technology permits bioreactor operation with considerably higher mixed liquor suspended solids (MLSS) concentration than ... Fixed-film or attached growth secondary treatment bioreactors are similar to a plug flow reactor model circulating water over ...
1000 liters Bioreactors. Vialing Station. In January 2009, JNIMC acquired Biocor vaccine manufacture facilities, a subsidiary ...
"Anaerobic Bioreactors Becoming Economical". Water Technology. 2 (4). July 1994. "Researchers Engineer New Methane-production ... In 1985, Shimizu Construction developed a bioreactor that uses Methanosarcina to treat waste water from food processing plants ... According to a 1994 report in Chemistry and Industry, bioreactors utilizing anaerobic digestion by Methanothrix soehngenii or ...
Decker, E. L.; Reski, R. (2007). "Moss bioreactors producing improved biopharmaceuticals". Current Opinion in Biotechnology. 18 ... implications for crop improvement or human health and the safe production of complex biopharmaceuticals in the moss bioreactor ...
In 2011, Reski and coworkers produced recombinant, biologically active human factor H in a moss bioreactor. In 2017 the first ... In the same year, Reski invented the moss bioreactor and founded "greenovation Biotech GmbH", a biotechnology company utilizing ... Decker, Eva L.; Reski, Ralf (2007). "Moss bioreactors producing improved biopharmaceuticals". Current Opinion in Biotechnology ... Bioreactor Technique May Offer Hope to People With Age-Related Blindness "Tough as old moss" - Ralf Reski explains in The ...
automated cell banking (cryovial handling) system Single use bioreactors Scaledown bioreactors Membrane chromatography devices ... BBI, the world's leading manufacturer of fermenters (bioreactor) and cell culture systems at the time, was integrated into the ... Retrieved 1 December 2017 - via BusinessWire.[self-published source] "Sartorius, Nova to Combine Bioreactor and Cell Analyzer ... DePalma, Angelo (1 August 2017). "True to Scale: Benchtop Bioreactors". Feature Articles. Genetic Engineering & Biotechnology ...
Eva L. Decker & Ralf Reski (2007). "Moss bioreactors producing improved biopharmaceuticals". Current Opinion in Biotechnology. ... Moss bioreactor with P. patens Four different ecotypes of P. patens stored at the International Moss Stock Center Protonema ... implications for crop improvement or human health and the safe production of complex biopharmaceuticals in moss bioreactors. By ...
Woodlawn Bioreactor. The parish has begun to be used as commuter zone for the nearby city of Canberra. The Woodlawn Wind Farm ...
"Bioreactor design." Basic biotechnology (2001): 151-72. Clean In Place Logic Programming Clean-in-place in pictures and ... Chisti, Y., Moo-Young, M. Clean-in-place systems for industrial bioreactors: Design, validation and operation. Journal of ... CIP is commonly used for cleaning bioreactors, fermenters, mix vessels, and other equipment used in biotech manufacturing, ... procedure for a bioreactor. PDA journal of pharmaceutical science and technology, 48(5), 236-240. Ostrove, Steve (2016). How to ...
Biological hydrogen can be produced in an algae bioreactor. In the late 1990s it was discovered that if the algae are deprived ... Biohydrogen can be produced in bioreactors. The process involves bacteria consuming hydrocarbons and producing hydrogen and CO2 ...
"Cultivation of Mammalian Cells in Bioreactors". Biotechnology Progress. 1 (4): 209-215. doi:10.1002/btpr.5420010404. "Dr. Wei- ...
They produce trachea scaffolds and bioreactors. Biostage has litigation over wrongful death pending that may affect Harvard ...
Bacteria digest waste in the lowest portion of the upflow reactor; the bioreactor zone. In between these two stages is the ...
Plants as bioreactors for vaccine production. Transgenic plants have been identified as promising expression systems for ... Bacteria are grown in bioreactors (e.g., Haemophilus influenzae type b). Likewise, a recombinant protein derived from the ...
Plants as bioreactors for vaccine production. The idea of vaccine production via transgenic plants was identified as early as ... Bacteria are grown in bioreactors (e.g., Haemophilus influenzae type b). Likewise, a recombinant protein derived from the ...
By 2001, the Aspen seep bioreactor treated 2.5 million gallons of ARD. The design evolved over time and in 2003, at the behest ... "Compost-Free Bioreactors Remove Metals from Acid Rock Drainage." Technology News and Trends. U.S. Environmental Protection ... In 1993 the State of California set up a pilot scale one-cell bioreactor with manure substrate for AMD treatment at Leviathan ... The sulfide effluent is passed into Bioreactor No. 2 for additional metal removal. Next, sodium hydroxide is added to the ...
... (EBR) is a type of a bioreactor used in water treatment. EBR is a high-efficiency denitrification, ... Higgins, J.; Mattes, A.; Stiebel, W.; Wootton, B. (2017). Eco-Engineered Bioreactors: Advanced Natural Wastewater Treatment. ... In conventional bioreactors, these electrons are provided by excess organic electron donors (e.g., organic carbon sources such ... metals, and inorganics removal technology that provides electrons directly to the EBR bioreactor as a substitute for using ...
Cyanobacteria bioreactors require high energy to operate. Cultures require constant mixing, and the harvesting of biosynthetic ... This susceptibility could potentially shut down entire bioreactors. Furthermore, the native reaction pathway for isobutanol in ... helping prevent contamination during growth in industrial bioreactors. S. cerevisiae cannot be affected by bacteriophages ...
"High Density Vertical Bioreactor". Valcent Products, Inc. Archived from the original on 2008-06-01. Retrieved 2008-06-18. " ... uses the High Density Vertical Bioreactor Virgin Green Fund Algae.Tec - an advanced biofuels company focused on commercializing ...
Introduced 'BioWiz' Smart Bioreactor. Praj Foundation is the CSR arm of PRAJ Industries Limited, established in 2004. ... CS1 maint: discouraged parameter (link) "Praj HiPurity Systems introduces BioWiz Smart Bioreactor". Financial Express. 23 ...
Algae filled bioreactors. *Polymer membrane gas separators. *Reversing heat exchangers. See also[edit]. *Carbon capture and ...
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BALs are essentially bioreactors, with embedded hepatocytes (liver cells) that perform the functions of a normal [liver]. They ... Currently, hollow-fibre bioreactors are the most commonly accepted design for clinical use due to their capillary-network ... After the experiment, they found that the cell-seeded bioreactors had reduced the levels of bilirubin and ammonia in the plasma ... This demonstrated that the HepG2 cells in the bioreactor were able to carry out detoxifying and synthetic functions of normal ...
The Membrane Bioreactor Book: Principles and Applications of Membrane Bioreactors for Water and Wastewater Treatment. Elsevier ... Relatively recent developments are membrane bioreactors (MBR) which combine microfiltration and a bioreactor for biological ... doi:10.1016/S0015-1882(05)70556-5. Pierre Le-Clech; Vicki Chen; Tony A.G. Fane (2006). "Fouling in membrane bioreactors used in ... Sun, Y; Huang, X.; Chen, E; Wen, X. (2004). "dual functional filtration/aeration membrane bioreactor for domestic wastewater ...
These systems are sometimes called "wetlands" or "bioreactors." Passive treatment systems differ from active systems (water ...
Other options for bioreactors are biopolymers and biofuels. Unlike bacteria, plants can modify the proteins post- ... Plants and plant cells have been genetically engineered for production of biopharmaceuticals in bioreactors, a process known as ... Lehr F, Posten C (June 2009). "Closed photo-bioreactors as tools for biofuel production". Current Opinion in Biotechnology. 20 ...
To date, many of the bioreactors used in cultured meat research have been at lab scale. The bioreactors used at the industrial ... Scaffolds are placed inside bioreactors so that cell growth and specialization can occur. Bioreactors are large machines ... Fixed bed bioreactors are commonly used for adherent cultures. They feature strips of fibres that are packed together to form a ... In airlift bioreactors, the culture media is aerated into a gaseous form using air bubbles which are then scattered and ...
Sharma, Arun K.; Sharma, Manoj K. (2009). "Plants as Bioreactors: Recent Developments and Emerging Opportunities". ...
In this work, a set of poly anhydride and poly(ethylene glycol) bioreactors are demonstrated with PuSL technology. The ... Further developments of this 3D microfabricated bioreactors are expected to have direct impact on applications such as analyte ... an innovative three dimensional microfabrication technology that will serve as a vehicle to enable vascularized bioreactors for ... and enhanced transport of nutrient and oxygen through advection represent the key advantages of the microfabricated bioreactors ...
England in October and Dutch company AlgaeLink will take the wraps off their latest bioreactors. The equip ... The resultant output of the bio-reactors could come out cleaner than it went in.. [Source: AutoIndustry.co.uk]. ... England in October and Dutch company AlgaeLink will take the wraps off their latest bioreactors. The equipment is designed to ...
These bioreactors are essentially flat containers with transparent walls that can be illuminated by sunshine or artificial ... These bioreactors produce biomass yields an order-of-magnitude greater than conventional cultivation methods. In their research ... The Ben-Gurion team created a physics model that explains some of the principal observations obtained in novel bioreactors that ... time scales characteristic of photosynthesis can be synchronized with the flow patterns and illumination of the bioreactors in ...
Sartorius Stedim Biotech supplies the widest range of bioreactors and fermentors for lab, pilot and process scale applications ... Sartorius Stedim Biotech supplies the widest range of bioreactors and fermentors for lab, pilot and process scale applications ...
The DASbox system is a system for parallel operation of four, eight, or more mini-bioreactors, which is suited for design of ... Benefits of Disposable Bioreactor Solutions. Novel Configurations Feature Control Capabilities Similar to Traditional Systems ... Both the BioBLU 0.3c and BioBLU 0.3f are specifically designed for use with the compact DASbox® mini-bioreactor system. ... The BioBLU 0.3f single-use bioreactor features working volumes of 65 to 250 mL. Integrated dip tubes permit the controlled ...
... and increasing the biomass concentration in the bioreactor. Two Phase Partitioning Bioreactors are able to reduce the aqueous ... With regards to bioreactor cell growth, substrate refers to the nutrients that the cells consume and is contained within the ... Substrate inhibition in bioreactors occurs when the concentration of substrate (such as glucose, salts, or phenols) exceeds the ... Cell growth in bioreactors depends on a wide range of environmental and physiological conditions such as substrate ...
Fouling can harm the overall efficiency of the bioreactor, especially the heat exchangers. To avoid it, the bioreactor must be ... An example of a continuous bioreactor is the chemostat.[citation needed] Organisms growing in bioreactors may be submerged in ... A typical bioreactor consists of following parts: Agitator - Used for the mixing of the contents of the reactor which keeps the ... These bioreactors are commonly cylindrical, ranging in size from litres to cubic metres, and are often made of stainless steel ...
This BCC Research report evaluates the global market membrane bioreactors (MBRs) used for wastewater treatment. Projections are ... accessing the global demand for membrane bioreactors.. SCOPE OF REPORT. The study is divided into chapters dealing with the ... Membrane bioreactor systems (MBRs) have, over the past years, emerged as an effective solution. to transforming various ... The global market for membrane bioreactor systems (MBRs) totaled $425.7 million in 2014 and is projected to approach $777.7 ...
... Yanli Wang,1,2 Sihai Zhao,1,2 Liang Bai,1,2 Jianglin Fan ... The term bioreactor, which originally meant a tank in which cells, cell extracts, or enzymes carried out a biological reaction ... Therefore, transgenic animal bioreactors show a financial advantage over cell culture or other systems, even when all costs are ... A. J. Harvey and R. Ivarie, "Validating the hen as a bioreactor for the production of exogenous proteins in egg white," Poultry ...
... Yanli Wang,1,2 Sihai Zhao,1,2 Liang Bai,1,2 Jianglin Fan ... A. J. Harvey and R. Ivarie, "Validating the hen as a bioreactor for the production of exogenous proteins in egg white," Poultry ... L. M. Houdebine, "Transgenic animal bioreactors," Transgenic Research, vol. 9, no. 4-5, pp. 305-320, 2000. View at Google ... D. E. Kerr, F. Liang, K. R. Bondioli et al., "The bladder as a bioreactor: urothelium production and secretion of growth ...
... Sartorius, Eppendorf, Chemtrix - published on openPR.com ... the report Global Micro Bioreactors Market 2017 describes Micro Bioreactors industry expansion game plan, the Micro Bioreactors ... The Micro Bioreactors report provides the past, present and future Micro Bioreactors industry Size, trends and the forecast ... Micro Bioreactors Market. Recent market study " Micro Bioreactors Market " analyses the crucial factors of the Micro ...
Bioreactor  Components of Bioreactor  Configurations  Operation modes  Summary * What is a bioreactor?  Bioreactor: ... Bioreactor-Load cell  A load cell is a scale that measures the weight of the bioreactor.  The weight of the bioreactor can be ... Bioreactor Operations Modes * 1. Batch Operation  A foam breaker may be installed to disperse foam. A batch bioreactor is ... Bioreactor-Vessel  The bioreactor vessel is a container which holds the media and the cells  Vessels can be made of glass, ...
Global Bioreactors and Fermenters Market to Reach $4.8 Billion by 2027 - Amid the COVID-19 crisis, the global market for ... The Bioreactors and Fermenters market in the U.S. is estimated at US$623.3 Million in the year 2020. China, the world`s second ... Single-use Bioreactors, one of the segments analyzed in the report, is projected to record 12.7% CAGR and reach US$2.2 Billion ... Global Bioreactors and Fermenters Market to Reach $4.8 Billion by 2027 - Amid the COVID-19 crisis, the global market for ...
Purchase On-line Estimation and Adaptive Control of Bioreactors, Volume 1 - 1st Edition. Print Book & E-Book. ISBN ... Software sensors for bioreactors. Adaptive control of bioreactors. Conclusions and perspectives. References and bibliography. ... Other parameter estimation issues in bioreactors. References and bibliography. Chapter 5. Adaptive Control of Bioreactors. ... a significant contribution to the problem of modelling, estimation and adaptive control of bioreactors. It is a highly valuable ...
Expansion of Human Induced Pluripotent Stem Cells in Stirred Suspension Bioreactors. In: Turksen K. (eds) Bioreactors in Stem ... Induced pluripotent stem cells Bioreactor Pluripotency Energy metabolism This is a preview of subscription content, log in to ... Shafa M, Day B, Yamashita A, Meng G, Liu S, Krawetz R, Rancourt DE (2012) Derivation of iPSCs in stirred suspension bioreactors ... dos Santos FF, Andrade PZ, da Silva CL, Cabral JM (2013) Bioreactor design for clinical-grade expansion of stem cells. ...
... algal droplet bioreactors on a chip the size of a quarter. ... bioreactors-on-a-chip-renew-promises-for-algal-biofuels/. ... In a chip housing millions of droplets of cells, each droplet is like a flask or a bioreactor, and thats how we can get ... Each droplet is a micro-bioreactor, a highly-controlled environment in which algal cells can grow and replicate for several ... Bioreactors on a chip renew promises for algal biofuels. Boyce Thompson Institute ...
Although the bioreactors are already a proven practice, more work remains to be done. ... Wood chip bioreactors are simple trenches that can be constructed on farms to clean the water that flows out of tile drains. ... Water pollution from agriculture: how wood chip bioreactors could help search for solutions Wood chip bioreactors are simple ... depends on the flow rate and the size of the bioreactor. Another challenge is that bioreactors work best in late summer, when ...
In vivo engineering of organs: The bone bioreactor. Molly M. Stevens, Robert P. Marini, Dirk Schaefer, Joshua Aronson, Robert ... In vivo engineering of organs: The bone bioreactor. Molly M. Stevens, Robert P. Marini, Dirk Schaefer, Joshua Aronson, Robert ... In vivo engineering of organs: The bone bioreactor. Molly M. Stevens, Robert P. Marini, Dirk Schaefer, Joshua Aronson, Robert ... Relevance of bioreactors and whole tissue cultures for the translation of new therapies to humans ...
Algae bioreactor absorbs CO2 better than trees. Posted A U.S.-based tech startup is using algae to play what could be an ...
This presentation offers information on the China membrane bioreactor market outlook and the ambitious water reuse targets ... Membrane bioreactor (mbr) case study by Fanny Zhang 1996 views * Membrane Bioreactor (MBR) Technolog... by Buzzards Bay Coal... ... Global Membrane Bioreactor (MBR) Ma... by Technavio 622 views * Membrane Bioreactor Technology - An... by Vaibhav Nautiyal ... China Membrane Bioreactor (mbr) Market Outlook- Ambitious Water Reuse Targets Boosting Membrane Industry ...
Bioreactors. Latest News. Single screen reactor control The METTLER TOLEDO RX-10 Reactor Control from LABTEX connects and ...
BR 10 Bioreactor is a progressive step forward, with an ... For more information about the IKA BR 10 Bioreactor, including ... The unit takes up less than half the space―and is priced at about half the price―of a traditional bioreactor. Yet, with ... Created in collaboration with marine scientists, the IKA® BR 10 Bioreactor is a progressive step forward, with an interface ...
View low-priced textbook options for Membrane BioReactors WEF Manual of Practice No. 36 on the eCampus.com Marketplace from our ... Membrane BioReactors WEF Manual of Practice No. 36. by WATER ENVIRONMENT FEDERATION *ISBN13: 9780071753661. ...
... by 2025 - published on openPR.com ... perfusion bioreactors and Large Scale (>1,000 liters) perfusion bioreactors. Small scale perfusion bioreactors are more often ... Perfusion bioreactor technology is thus expected to be a dominant single-use bioreactor technology over the forecast period of ... Unlike traditional fed-batch bioreactors, perfusion bioreactors culture cells for a long period of time and by continuously ...
Results for bioreactor control equipment from Solida-Biotech, FerMac, bbi and other leading brands. Compare and contact a ... Pro Mill - Bioreactor. Bioreactor is a device, in which a biological process is carried out, especially on industrial scale. ... FerMac - Model 320 - Bioreactor Fermenters. Outstanding value-for-money package- An autoclavable, bench-top bioreactor control ... FerMac - Model 200 - Bioreactor Control System. A low maintenance, modular, autoclavable cost effective bioreactor control ...
Combined application of bioreactors and membrane separations are considered as membrane bioreactors (MBRs). Examples for the ... Combined application of bioreactors and membrane separations are considered as membrane bioreactors (MBRs). Examples for the ... When the bioreactor is integrated by a membrane gas separation unit (MBR), higher productivity was possible to achieve, as ... "As per definition, the bioreactor is the designed space where biochemical reactions take place" [1]. If some compounds should ...
So far, membrane bioreactors for waste gas treatment have only been tested on laboratory scale. If the long-term stability of ... The membrane bioreactor combines the advantages of membrane devices with the clean technology of biological air purification. ... In this type of bioreactor gaseous pollutants are transferred through a membrane to the liquid phase, where micro-organisms ... these reactors can be demonstrated, we expect membrane bioreactors to be useful tools in the treatment of gas streams ...
Fermentation bioreactor. Fabrice Martin. This web site aggregates information about life sciences and biotechs. It has been ... Benjamin Neel was in Canada during its third year of PhD when he started to think about his fermentation bioreactor: a web ...
Development of magnetically active scaffolds as intrinsically-deformable bioreactors - Volume 7 Issue 3 - Darina A. Gilroy, ... 6.Plunkett, N. and OBrien, F.J.: Bioreactors in tissue engineering. Technol. Health Care. 19, 55 (2011). ... 25.Schulz, R.M. and Bader, A.: Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of ... 8.Martin, Y. and Vermette, P.: Bioreactors for tissue mass culture: design, characterization, and recent advances. Biomaterials ...
"The bioreactor device created a supportive environment for the wound where the tissue could grow as it did during embryogenesis ... The scientists 3D printed the bioreactor out of silicon and filled it with hydrogel--a sticky glob of polymers. They laced the ... They saw that, unlike in the control and sham groups, the regenerating limbs of the bioreactor-treated frogs were thicker with ... When they looked at the experimental group frogs at different time points over 9.5 months, they noticed that the bioreactor ...
  • This BCC Research report evaluates the global market membrane bioreactors (MBRs) used for wastewater treatment. (reportlinker.com)
  • Evaluate the global market for membrane bioreactors (MBRs) used for wastewater treatment by regions and major market segments for a five-year horizon. (reportlinker.com)
  • The Bioprocess Intelligent Optimization System (BIOS) is an integrated hardware and software system that enables real-time monitoring and control of wastewater treatment operations based on the dynamically changing biological activity occurring in the bioreactor . (environmental-expert.com)
  • Membrane bioreactor (MBR) technology is a wastewater treatment method combining biological pollutant treatment with physical membrane separation. (environmental-expert.com)
  • Principles of Membrane Bioreactors for Wastewater Treatment Is a practical handbook for Membrane Bioreactor design and operation Provides an understanding of how membrane fouling and channel cleaning can impact plant operation and how to optimize operating parameter values. (environmental-expert.com)
  • This has led to the examination of membrane bioreactor (MBR) technology for wastewater treatment, since it offers the best and most consistent treated water quality of all biotreatment processes. (bl.uk)
  • Biopharmaceutical industry is striving to drive the product yield yet reducing the operational cost and perfusion bioreactors offer legacy of cost saving, increase productivity & efficiency of protein production. (openpr.com)
  • Unlike traditional fed-batch bioreactors, perfusion bioreactors culture cells for a long period of time and by continuously feeding fresh media to cell culture and remove the used media while keeping the cells in culture. (openpr.com)
  • Use of perfusion bioreactors also eliminates chances of protein degradation due to toxic effects produced by accumulation of cellular waste products in the culture media. (openpr.com)
  • Other advantages of perfusion bioreactors over traditional fed-batch reactors is that they are smaller in size and provide easy scalability in case of increased demand. (openpr.com)
  • Perfusion bioreactor technology is thus expected to be a dominant single-use bioreactor technology over the forecast period of 2017-2025. (openpr.com)
  • Some of the applications of perfusion bioreactors include manufacturing of hybridoma-based monoclonal antibodies, stem cell culturing, protein production, in vitro cell based drug screening, production of cell based assays, CHO-based biopharmaceutical manufacturing and many other. (openpr.com)
  • Perfusion bioreactors require cell retention or filtration devices during the continuous feed and removal of exhausted culture media. (openpr.com)
  • Perfusion bioreactors can be used at small scale as well as large scale bioproduction. (openpr.com)
  • For instance, Remicade - blockbuster antibody preparation by Janssen Biotech, Inc. employs perfusion bioreactor technology for production. (openpr.com)
  • Primary factors driving the growth of global perfusion bioreactors market are size advantage, cost-effective, requirement of less capital investment, reduced operating cost, improvement in equipment reliability etc. (openpr.com)
  • Several other factors influencing the global market for perfusion bioreactors are increasing budget of biopharmaceutical companies in all areas related to bioprocessing, investment in adoption of new technologies, continuous discovery of numerous cost and performance advantages of perfusion technology, technological advances such as 3Dperfusion technology etc. (openpr.com)
  • However, the global market for perfusion bioreactors is expected to be deter by apparent lack of innovation in bioprocessing equipment, reliability of cell retention devices when used on industrial plant scale, etc. (openpr.com)
  • Based on product type, the global perfusion bioreactors market has been classified as small scale (50 liters to 1,000 liters capacity) perfusion bioreactors and Large Scale (>1,000 liters) perfusion bioreactors. (openpr.com)
  • Small scale perfusion bioreactors are more often used by biopharmaceutical companies. (openpr.com)
  • However, demand for large scale perfusion bioreactors is increasing with increasing efforts to expand the production capacity by the companies. (openpr.com)
  • Based on end user, the global perfusion bioreactors market has been segmented into biopharmaceutical companies, biotechnology companies and contract manufacturing organizations. (openpr.com)
  • Biopharmaceutical companies are expected to contribute highest share in the global perfusion bioreactors market over the forecast period. (openpr.com)
  • On the basis of regional presence, global perfusion bioreactors market is segmented into five key regions viz. (openpr.com)
  • Some of the players operating in global perfusion bioreactors market are Sigma Aldrich Co. LLC (Merck & Co. Inc.), FiberCell Systems Inc., Zellwerk GmbH, Cell Culture Company, ATMI Incorporated, PBS Biotech, Inc., GE Healthcare Life Sciences, Applikon Biotechnology, WAVE Life Sciences etc. (openpr.com)
  • Previously, we developed a novel tubular perfusion system (TPS) bioreactor, which allows the dynamic culture of bead-encapsulated cells and increases the supply of nutrients to the entire cell population. (nih.gov)
  • Abstract This project will develop and demonstrate a prototype Modular Perfusion Bioreactor (MPB) for tissue engineering applications. (sbir.gov)
  • As a starting point for this multi-functional system, Resodyn Corporation will use its highly scalable (50-1,500ml) and successful (>1x108 cells/ml) hypoxia perfusion bioreactor. (sbir.gov)
  • As a result of this collaboration, end users will stand to benefit from a single control system for 50 L to 2,000 L bioreactors used in perfusion cell culture applications. (biospace.com)
  • Through the partnership, Sartorius Stedim Biotech and Repligen will further collaborate to equip SSB's recently launched ambr® 250ht perfusion single-use mini bioreactor system with Repligen's KrosFlo® hollow fiber filter technology. (biospace.com)
  • The integration of our market-leading XCell™ ATF control technology with SSB's high-performance bioreactors offers a simplified perfusion-enabled bioreactor solution for end users to develop cell culture processes more quickly and implement perfusion more efficiently. (biospace.com)
  • Bose Corporation has introduced the 3DCulturePro™ system, a new multi-specimen perfusion bioreactor designed for biologists, biomedical researchers and scientists who require reproducible and reliable tissue growth. (news-medical.net)
  • Retrieved on November 25, 2020 from https://www.news-medical.net/news/20141112/New-multi-specimen-perfusion-bioreactor-for-reliable-tissue-growth-introduced-by-Bose.aspx. (news-medical.net)
  • The Applikon® miniBio bioreactor can be seen on benchtops around the world being used for small-scale operations such as screening studies, media optimization, process optimization, microbial and cell culture batch, fed-batch, perfusion and continuous cultivation. (coleparmer.com)
  • The global market for membrane bioreactor systems (MBRs) totaled $425.7 million in 2014 and is projected to approach $777.7 million by 2019, registering a compound annual growth rate (CAGR) of 12.8% through 2019. (reportlinker.com)
  • Membrane bioreactor systems (MBRs) have, over the past years, emerged as an effective solution to transforming various wastewaters into high-quality effluent suitable for discharge to the environment and increasingly into a reusable product. (reportlinker.com)
  • Combined application of bioreactors and membrane separations are considered as membrane bioreactors (MBRs). (intechopen.com)
  • Application of membranes integrated in bioreactions is often considered as membrane bioreactors (MBRs). (intechopen.com)
  • The global market for membrane bioreactors (MBRs) should grow from $1.9 billion in 2018 to reach $3.8 billion by 2023 at a compound annual growth rate (CAGR) of 14.7% for the period of 2018-2023. (bccresearch.com)
  • Challenge testing has demonstrated high protozoa and virus log reduction values (LRV) by membrane bioreactors (MBRs) , greater than six in many cases. (wwdmag.com)
  • Microorganisms in membrane bioreactors (MBRs) play important roles on degradation of organic/inorganic substances in wastewaters, while microbial deposition/growth and microbial product accumulation on membranes potentially induce membrane fouling. (mdpi.com)
  • Fermenter: Fermenter is a type of bioreactor in which the biocatalyst is a living cell. (speakerdeck.com)
  • In this type of bioreactor gaseous pollutants are transferred through a membrane to the liquid phase, where micro-organisms degrade the pollutants. (wur.nl)
  • The simplest type of bioreactor is the batch reactor, which is a closed system containing cell culture media and a population of cells. (jove.com)
  • Amid the COVID-19 crisis, the global market for Bioreactors and Fermenters estimated at US$2.3 Billion in the year 2020, is projected to reach a revised size of US$4.8 Billion by 2027, growing at aCAGR of 10.9% over the period 2020-2027. (reportlinker.com)
  • The Bioreactors and Fermenters market in the U.S. is estimated at US$623.3 Million in the year 2020. (reportlinker.com)
  • Bioreactors, also known as fermenters, are cell culture systems that provide suitable growth environments. (jove.com)
  • Application of bioreactors, including fermenters, are for production of bioethanol and other biofuels, pharmaceutical products, fine chemical products, food and beverages and tissue growth. (bronkhorst.com)
  • In one case, a bioreactor is a vessel in which a chemical process is carried out which involves organisms or biochemically active substances derived from such organisms. (wikipedia.org)
  • The term bioreactor, which originally meant a tank in which cells, cell extracts, or enzymes carried out a biological reaction, now often refers to a growth chamber (fermenter or fermentation vessel) for cells or microorganisms used in the production of recombinant proteins. (hindawi.com)
  • Fed-Batch: The bioreactor is a batch process in the beginning and after a certain point a feed input is introduced and the volume of the vessel increases. (speakerdeck.com)
  • All the additional parts of a bioreactor connect to the vessel. (speakerdeck.com)
  • If possible, use an external temperature sensor for the autoclave temperature mounted in the temperature sensor pocket of the bioreactor vessel. (pressebox.de)
  • We have developed a biomimetic microfluidic platelet bioreactor that recapitulates bone marrow and blood vessel microenvironments. (bloodjournal.org)
  • Simply said, a bioreactor is a vessel in which biological processes take place. (bronkhorst.com)
  • The relatively low solubility of oxygen, however, makes the choice of mixer impeller configuration a critical design factor for the bioreactor vessel. (pharmtech.com)
  • This article describes a series of experiments and computational fluid dynamics (CFD) simulations to detail the effect of mixer configuration on the efficiency and effectiveness of a bioreactor vessel with respect to blend time and mass transfer. (pharmtech.com)
  • Two types of bioreactors are commonly used in cell culture, batch and continuous stirred tank bioreactors. (jove.com)
  • Recent studies on cell culture in stirred tank bioreactors indicate that mechanical forces resulting from the interaction of the cells with the turbulent eddies significantly affect the differentiation propensity of stem cells. (nsti.org)
  • The environmental conditions inside the bioreactor, such as temperature, nutrient concentrations, pH, and dissolved gases (especially oxygen for aerobic fermentations) affect the growth and productivity of the organisms. (wikipedia.org)
  • Bubble columns maintain aeration and low shear conditions inside the bioreactor. (marketsandmarkets.com)
  • article{95aeff23-01d1-4b7b-b21a-f77d899813c5, abstract = {Analysis of bioreactors is central for successful design and operation of biotechnical processes. (lu.se)
  • In their research the scientists explain that it's critical to account for the unique interplay between physics and biology: Intrinsic time scales characteristic of photosynthesis can be synchronized with the flow patterns and illumination of the bioreactors in which the algae are grown. (redorbit.com)
  • Astronauts on the International Space Station will begin testing an innovative algae-powered bioreactor to assess its feasibility for future long-duration space missions. (space.com)
  • The algae-powered bioreactor, called the Photobioreactor, represents a major step toward creating a closed-loop life-support system, which could one day sustain astronauts without cargo resupply missions from Earth. (space.com)
  • AUSTIN, Texas , Sept. 17, 2019 /PRNewswire/ -- Hypergiant Industries, the AI products and solutions company, announces the launch of the Eos Bioreactor, a green energy solution that captures and sequesters carbon from the atmosphere using algae. (prnewswire.com)
  • This device uses AI to optimize algae growth, carbon capture and algae output creating a product that is more sustainable, efficient, manageable and smaller in size than other bioreactor prototypes. (prnewswire.com)
  • This has been studied deeply in the past decade with the biggest challenge being our ability to create efficient bioreactors that harness the power of algae efficiently and effectively. (prnewswire.com)
  • Solix officials estimate that widespread construction of its photo-bioreactor system could meet the demand for the U.S. consumption of diesel fuel - about 4 million barrels a day - by growing algae on less than 0.5 percent of the U.S. land area, which is otherwise unused land adjacent to power plants and ethanol plants. (coloradoindependent.com)
  • These bioreactors produce biomass yields an order-of-magnitude greater than conventional cultivation methods. (redorbit.com)
  • Use of a special bioreactor for the cultivation of a new flexible polyurethane scaffold for aortic valve tissue engineering. (springer.com)
  • By using the IKA photo bioreactors, the cultivation of phototrophic microorganisms such as microalgae or cyanobacteria are, under carefully controlled conditions in a closed system, easily possible. (ika.com)
  • DASGIP AG develops and manufactures technologically advanced Parallel Bioreactor Systems for the cultivation of microbial, plant, animal and human cells at bench top scale. (innovations-report.com)
  • Scientists explain why a microalgae bioreactor redesign provides an order-of-magnitude improvement over conventional cultivation methods. (phys.org)
  • Disposable Bioreactors are used for cell cultivation because they improve process flexibility, decrease turn over time and eliminate the cleaning and sterilization process. (medgadget.com)
  • citation needed] On the basis of mode of operation, a bioreactor may be classified as batch, fed batch or continuous (e.g. a continuous stirred-tank reactor model). (wikipedia.org)
  • An example of a continuous bioreactor is the chemostat. (wikipedia.org)
  • Continuous: The bioreactor starts with an initial volume and media is constantly introduced and product is constantly taken out. (speakerdeck.com)
  • BPC® BioReactor Simulator (BRS) is a universal platform for simulating anaerobic fermentation processes in a continuous mode of operation. (environmental-expert.com)
  • This video presents batch and continuous reactors and demonstrates the use of bioreactors to grow bacteria in the laboratory. (jove.com)
  • With SCHOTT ViewPort™ process analytical technology (PAT) components, continuous in-situ measurement is possible without penetrating the bioreactor barrier. (schott.com)
  • Continuous optimization, design improvements and characterization of bioreactors are crucial factors placing high demands for innovation in biopharmaceutical manufacturing. (ispe.org)
  • We present here an innovative three dimensional microfabrication technology that will serve as a vehicle to enable vascularized bioreactors for in vitro tissue culture. (nsti.org)
  • Further developments of this 3D microfabricated bioreactors are expected to have direct impact on applications such as analyte controlled and modulated drug and protein delivery, drug targeting, tissue engineering, and micro- or nano-devices. (nsti.org)
  • The bioreactor device created a supportive environment for the wound where the tissue could grow as it did during embryogenesis," says Levin. (eurekalert.org)
  • A very brief application of bioreactor and its payload triggered months of tissue growth and patterning. (eurekalert.org)
  • Dynamic Bioreactor Culture of High Volume Engineered Bone Tissue. (nih.gov)
  • More interestingly, the versatility of TPS bioreactor allows a large range of engineered tissue volumes to be cultured, including large bone grafts. (nih.gov)
  • Bioreactors for heart valve tissue engineering: a review. (springer.com)
  • Aim of the present project is the modelling and numerical simulation of soft-tissue growth in rotating bioreactors and related morphological evolution. (findaphd.com)
  • Developed in 1986 by a group of NASA engineers and researchers at the agency's Johnson Space Center in Houston, the device, known as the bioreactor, enables the growth of tissue, cancer tumors and virus cultures outside the body in space and on Earth. (spaceref.com)
  • However, tissues grown in the bioreactor are larger and three-dimensional, with structural and chemical characteristics similar to normal tissue. (spaceref.com)
  • While many unique styles of bioreactors have been proposed for various types of stem cell and tissue cultures, there is not a single, easy-to-use device that accommodates the multiple diverse needs of multiple tissue culture types. (sbir.gov)
  • In order to take advantage of recent advances in stem cell culture, biomaterials, and tissue engineering techniques, Resodyn Corporation proposes to develop, design, fabricate, and test a multi-functional bioreactor platform system. (sbir.gov)
  • The mPath benchtop bioreactor control system is a first-of-its-kind solution to deliver accurate measurement and control of single-use process development-scale bioprocesses. (medindia.net)
  • Benchtop and industrial bioreactors can benefit from Bronkhorst's reliable, accurate, compact and robust flow instruments. (bronkhorst.com)
  • DASGIP AG, a leading provider of parallel bioreactor systems at benchtop scale, is giving users of its technology the freedom and flexibility to access their bioprocesses online. (innovations-report.com)
  • With the Remote Control Suite, DASGIP Parallel Bioreactor Systems are offering unmatched bioprocess control at benchtop scale. (innovations-report.com)
  • Both the BioBLU 0.3c and BioBLU 0.3f are specifically designed for use with the compact DASbox® mini-bioreactor system. (genengnews.com)
  • This presentation offers information on the China membrane bioreactor market outlook and the ambitious water reuse targets boosting membrane industry. (slideshare.net)
  • Based on the various configurations of membrane bioreactor system the global membrane bioreactor market can be divided in two broad segments namely internal membrane bioreactor system, and exterior membrane bioreactor system. (automation.com)
  • Sartorius Stedim Biotech supplies the widest range of bioreactors and fermentors for lab, pilot and process scale applications. (sartorius.com)
  • Christine Gebski, Vice President of Product Management at Repligen, stated, "We are excited to partner with Sartorius Stedim Biotech, a global innovator in bioreactor technology. (biospace.com)
  • Apart from aforementioned factors, cellbag bioreactor chambers market is driven by increased research and development activities by governmental institutions and biopharmaceutical companies in the field of drug discovery and rising product pipeline of biologics of several biotech and Pharma companies expected drive the market revenue growth in foreseeable future. (medgadget.com)
  • Some of the players in the global cellbag bioreactor chambers market are GE Healthcare, Merck Millipore, Thermo Fisher Scientific, Inc., Danaher Corporation, Sartorius Stedim Biotech S.A. to name a few. (medgadget.com)
  • By slowly adding substrate into the medium, fed-batch bioreactor systems can help alleviate substrate inhibition. (wikipedia.org)
  • In this paper, we compared different systems capable of producing therapeutic proteins (bacteria, mammalian cells, transgenic plants, and transgenic animals) and found that transgenic animals were potentially ideal bioreactors for the synthesis of pharmaceutical protein complexes. (hindawi.com)
  • Compared with other systems of production for recombinant proteins, transgenic animal bioreactors are, overall, an attractive platform because transgenic animal bioreactors represent powerful tools to address the growing need for therapeutic recombinant proteins. (hindawi.com)
  • Although direct comparison of the production costs associated with these different systems is rather difficult, a previous study suggested that building a large-scale (10,000 liter bioreactor) manufacturing facility for mammalian cells takes 3-5 years and costs US$ 250-500 million, whereas a transgenic farm with a single purification facility should not cost more than US$ 80 million and would most likely cost less [ 7 ]. (hindawi.com)
  • Therefore, transgenic animal bioreactors show a financial advantage over cell culture or other systems, even when all costs are taken into account. (hindawi.com)
  • The company's systems include patented processes such as membrane bioreactors (MBR), anaerobic digesters, sequenced batch reactors, and membrane filtration, in addition to techniques such as absorption, dissolved air flotation, sand filtration, oxidation and activated carbon amongst many others. (edie.net)
  • These membrane bioreactor systems, combined with Ultrafiltration separation, have been used on a variety of effluent streams across Europe. (edie.net)
  • Process engineers, scientists and product developers from biotechnological, pharmaceutical and chemical companies as well as research institutions use DASGIP Parallel Bioreactor Systems for their biotechnological processes and benefit from increased productivity, high reproducibility, and ease of scale up, resulting in accelerated product development cycles. (innovations-report.com)
  • By product, the SUB systems segment is expected to account for the largest share of the global single use bioreactor market. (marketsandmarkets.com)
  • On the basis of products, the single use bioreactor (SUBs) market is categorized into media bags, SUB systems, filtration assemblies, and other products such as tubing, connectors, sampling systems, and probes/sensors. (marketsandmarkets.com)
  • However, the actual translation of such developments into therapeutic applications demands robust, flexible, and cost-effective bioreactor systems. (marketsandmarkets.com)
  • PURON® PLUS MBR Packaged Systems are skid-mounted membrane bioreactor plants that provide full scope of supply, from prescreening and biological treatment through to final membrane clarification step. (thomasnet.com)
  • This new generation of bioreactors will produce large quantities of cell mass in a quarter of the time taken by conventional systems. (eurekanetwork.org)
  • Disposable bioreactor systems are technologies commonly used in bioprocessing. (bioprocessintl.com)
  • Applikon Biotechnology is a global leader in developing and supplying advanced bioreactor systems for the production of vaccines, antibodies, tissues, bio-pharmaceuticals, nutraceuticals and biosimilars in the pharmaceutical industry, as well as enzymes, food, feed, bio-fuel, bio-chemicals and bio-plastics for industrial biotechnology. (coleparmer.com)
  • SCHOTT ViewPort™ is suitable for bioreactors of varying sizes and includes a standard port diameter and flange size for easy integration into existing systems and designs. (schott.com)
  • Currently, a number of teams have shown that engineered erythrocytes can behave as circulating bioreactors for the degradation of toxic metabolites or the inactivation of xenobiotics, as drug delivery systems, as carriers of antigens of vaccinal interest, and in many others biomedical applications. (waterstones.com)
  • These Applikon turnkey bioreactor systems are equipped with all necessary components and accessories to get started r. (getinge.com)
  • Catering to the diverse requirements of our esteemed clients, we offer Membrane Bioreactor Systems to recycle and RO feed of the contaminated water & get high quality processed water. (tradeindia.com)
  • In waste water treatment activities, we use Membrane Bioreactor Systems to purify water from sewages and effluents. (tradeindia.com)
  • The mass transfer coefficient (k L )and the value of the interfacial area (a), is used to characterize bioreactor systems for their oxygen transfer capability. (ispe.org)
  • The miniBio range of bioreactors (250 mL, 500 mL and 1000 mL total volume) is a true scale down of the laboratory-scale bioreactor. (coleparmer.com)
  • If the long-term stability of these reactors can be demonstrated, we expect membrane bioreactors to be useful tools in the treatment of gas streams containing poorly water-soluble pollutants and highly chlorinated hydrocarbons, which are difficult to treat with the conventional methods for biofiltration. (wur.nl)
  • When considering bioreactor configurations, it is helpful to keep in mind that batch reactors are often used because of their simplicity and low cost, although cell density is limited. (jove.com)
  • For projects proposing clinical grade bioreactors and clinical investigations, an applicant must provide evidence that they have contacted the Food and Drug Administration (FDA) for guidance concerning the development of their bioreactor device, such as correspondence regarding investigational new drug (IND) application and status of their project in a timeline related to Federal regulatory approval processes. (nih.gov)
  • Enable safe and sterile processes by enabling in-situ measurement through hermetically sealed optical windows without having to open the bioreactor for physical sampling. (schott.com)
  • Bioreactors are devices that maintain a specific environment to allow organisms or their derivative substances to undergo chemical processes. (sciencephoto.com)
  • Analysis of bioreactors is central for successful design and operation of biotechnical processes. (lu.se)
  • Vessels, or bioreactors, capable of supporting these processes in microgravity must be developed. (sae.org)
  • Biotechnological processes are conducted in a bioreactor, where substances are being synthesized with the help of bacterial, yeast- and cell strains. (bronkhorst.com)
  • In short, reliability and reproducibility are key in bioreactor processes , especially for flow control. (bronkhorst.com)
  • A bioreactor refers to any manufactured device or system that supports a biologically active environment. (wikipedia.org)
  • The DASbox system is a system for parallel operation of four, eight, or more mini-bioreactors, which is suited for design of experiment, bioprocess development screening, and for use as a scale-down model. (genengnews.com)
  • A low maintenance, modular, autoclavable cost effective bioreactor control system. (environmental-expert.com)
  • Fiber cable for pH and DO control , to be used with the ReadyToProcess WAVE 25 bioreactor system. (environmental-expert.com)
  • A versatile fermenter designed with the modern laboratory in mind- An autoclavable, bench-top bioreactor control system. (environmental-expert.com)
  • Outstanding value-for-money package- An autoclavable, bench-top bioreactor control system. (environmental-expert.com)
  • The consulting engineer selected a membrane bioreactor (MBR) system to avoid the need for huge tank volumes and to provide the future possibility of water re-use. (ingentaconnect.com)
  • In order to advance a wide variety of TEHV approaches, the goal of this study was to develop a cardiac valve bioreactor system capable of conditioning living valves with a range of hydrodynamic conditions as well as capable of assessing hydrodynamic performance to ISO 5840 standards. (springer.com)
  • A bioreactor system was designed based on the Windkessel approach. (springer.com)
  • The bioreactor system was able to produce a range of pressure and flow conditions from static to resting adult left ventricular outflow tract to pathological including hypertension. (springer.com)
  • We have developed a single bioreactor system that allows for step-wise conditioning protocols to be developed for each unique TEHV design as well as allows for hydrodynamic performance assessment. (springer.com)
  • Design and validation of a novel splashing bioreactor system for use in mitral valve organ culture. (springer.com)
  • is pleased to introduce the mPath bioreactor control system to the biopharmaceutical market. (medindia.net)
  • Throughout the development of the mPath bioreactor control system, our team was focused on simplifying single-use lab-scale bioprocesses with a functional, integrated user experience," explained Loe Cameron , Director of Analytics and Controls at Pall. (medindia.net)
  • Additionally, the mPath bioreactor control system has been designed to support characterization and optimization and is compliant with cGMP regulations. (medindia.net)
  • An expandable control and data management system includes both bioreactor control towers and an advanced supervisory control and data acquisition (SCADA) software package. (medindia.net)
  • The launch of the mPath bioreactor control system represents the first in our next generation of unifying technologies for a seamless, fully controlled, and value-based user experience. (medindia.net)
  • The Urea Bioreactor Electrochemical (UBE) system is the closest thing we have yet to the "Mr Fusion" Home Energy Reactor, which Doc Brown affixed to his DeLorean time machine after his first visit to 2015. (news.com.au)
  • The Advanced Control Bioreactor System BR1000 automates lab-scale mammalian cell culture with highly accurate real-time monitoring and advanced process control. (yokogawa.com)
  • The bioreactor system provides advanced process control driven by innovative hardware and software technologies to improve reproducibility and stability of cell culture conditions for better biopharmaceuticals. (yokogawa.com)
  • SSB's new bioreactor is designed for scale-out expansion of cells including patient-specific T cells and is a closed system, consisting of an automated control unit and a up to two rocking platforms to gently agitate single-use Flexsafe® RM TX bags (up to 5L working volume). (ecmconnection.com)
  • Utilizing this bioreactor system, manufacturers can attach a second rocking platform and Flexsafe® RM TX bag to each BIOSTAT® B control unit to scale-out their production. (ecmconnection.com)
  • Membrane bioreactor system (MBR) is very effective against some of the most commonly found pathogens such as cryptosporidium and giardia witch cannot be eliminated with other traditional waste water treatment process such as chorine. (automation.com)
  • On the basis of the various application of membrane bioreactor system the overall market can be divided into two broad categories namely, industrial waste water treatment and municipal waste water treatment. (automation.com)
  • Asia Pacific is the fasted growing region for membrane bioreactor system fueled mainly from growing manufacturing industries of India and China. (automation.com)
  • The system studied here is the ReadyToProcess WAVE 25 bioreactor (GE Healthcare Life Sciences). (bioprocessintl.com)
  • The bioreactor system will be sold by SSB as a complete single-use assembly. (biospace.com)
  • The Applikon bioreactor system portfolio covers the whole upstream bioprocess, ranging from laboratory scale and pilot plant scale to production scale. (getinge.com)
  • The global membrane bioreactor is going through many merger and acquisition in recent years in order to enhance technological base, geographical reach, product portfolio and larger consumers' base. (automation.com)
  • The bioreactors are used for growing organisms such as yeast, bacteria, or animal cells in a biologically active environment. (marketpublishers.com)
  • Small-scale bioreactor used for studying bacteria. (sciencephoto.com)
  • The majority of bioreactors need to be supplied with gases and nutrients for growing bacteria, yeast or cells for the desired biological synthesis to take place. (bronkhorst.com)
  • An annular flow bioreactor has been conceived. (sae.org)
  • It is shown analytically that liquid film thickness is limited only by vane geometry and that an annular flow bioreactor capable of managing 284 liters would occupy 0.7 m 3 , less than half the volume of a Spacelab experiment rack. (sae.org)
  • Deb Audino from Great Bay Community College demonstrates how to end a run in the Applikon Bioreactor and take it apart. (bio-link.org)
  • You might also like to see how to assemble and run an Applikon Bioreactor . (bio-link.org)
  • Bioreactor design: reactor size, tank geometry, aeration amount. (environmental-expert.com)
  • The gases that are commonly used for the aeration of bioreactors are: Air, O2 (Oxygen), N2 (Nitrogen) and CO2 (Carbon dioxide). (bronkhorst.com)
  • Day B, Rancourt DE (2013) Metabolic status of pluripotent cells and exploitation for growth in stirred suspension bioreactors. (springer.com)
  • Benjamin Neel was in Canada during its third year of PhD when he started to think about his 'fermentation bioreactor': a web site which would use all 'web 2.0' technologies to bring together all possible information scattered on the Internet about his disciplinary field: Life science and biotechnologies. (asso.fr)
  • Typically, the bioreactor process is a batch process and the time between start and harvesting is called a campaign. (bronkhorst.com)
  • The U.S. is the largest market for membrane bioreactor in North America mainly attributed to the high share of sludge treatment plant and manufacturing industries of this region. (automation.com)
  • North America dominates the market for bioreactors followed by Europe. (marketpublishers.com)
  • North America and Europe will remain key market for global cellbag bioreactor chambers market due to rising R&D activities by key players, increasing biologics patent expiries and governments initiatives helps to maintain larger market share in the globalcellbag bioreactor chambers market by the region. (medgadget.com)
  • Large scale immobilized cell bioreactors are: moving media, also known as moving bed biofilm reactor (MBBR) packed bed fibrous bed membrane Bioreactor design is a relatively complex engineering task, which is studied in the discipline of biochemical/bioprocess engineering. (wikipedia.org)
  • Hunt MM, Meng G, Rancourt DE, Gates ID, Kallos MS (2014) Factorial experimental design for the culture of human embryonic stem cells as aggregates in stirred suspension bioreactors reveals the potential for interaction effects between bioprocess parameters. (springer.com)
  • Further, extensive technological advancement in the field of bioprocess equipment will drive the growth of the bioreactor market in the North American Region. (marketpublishers.com)
  • If some compounds should be removed from the bioreactor, a separation step can be connected to the reactor. (intechopen.com)
  • In membrane bioreactor treatment process, membrane unit are exposed to the sludge that has be treated combine with biological process and the solid-liquid separation process together in single stage. (automation.com)
  • Membrane bioreactors (MBR) combines membrane separation process with biological treatment of wastewater. (ecolab.com)
  • This book discusses recent trends and developments in the microbial conversion process, which serves as an important route for biofuel production, with particular attention to bioreactors. (books.com.tw)
  • Applikon bioreactors can easily be configured to match your microbial or cell culture application. (getinge.com)
  • By leaving the source of light apart the device can be used as a conventional bioreactor as well as a fermenter. (ika.com)
  • Substrate inhibition in bioreactors occurs when the concentration of substrate (such as glucose, salts, or phenols) exceeds the optimal parameters and reduces the growth rate of the cells within the bioreactor. (wikipedia.org)
  • With regards to bioreactor cell growth, substrate refers to the nutrients that the cells consume and is contained within the bioreactor medium. (wikipedia.org)
  • Krawetz R, Taiani JT, Liu S, Meng G, Li X, Kallos MS, Rancourt DE (2010) Large-scale expansion of pluripotent human embryonic stem cells in stirred-suspension bioreactors. (springer.com)
  • Kehoe DE, Jing D, Lock LT, Tzanakakis ES (2010) Scalable stirred-suspension bioreactor culture of human pluripotent stem cells. (springer.com)
  • dos Santos FF, Andrade PZ, da Silva CL, Cabral JM (2013) Bioreactor design for clinical-grade expansion of stem cells. (springer.com)
  • Each droplet is a micro-bioreactor, a highly-controlled environment in which algal cells can grow and replicate for several days, forming a genetically homogenous colony that goes through its typical biological reactions, including the production of lipids. (eurekalert.org)
  • In a chip housing millions of droplets of cells, each droplet is like a flask or a bioreactor, and that's how we can get results faster from just a tiny chip," explained author and BTI post-doc, Shih-Chi Hsu . (eurekalert.org)
  • RNA sequencing and transcriptome analysis revealed that the bioreactor had altered the gene expression occurring in cells at the amputation site. (eurekalert.org)
  • The core objective of the PhD is to develop a new pneumatic (hydrostatic) pressure bioreactor for manufacturing mesenchymal stem cells. (findaphd.com)
  • Attribute Sciences, Process Development, Amgen Biopharmaceuticals are drugs manufactured bygrowing genetically engineered cells in bioreactors to produce a therapeutic protein. (brighttalk.com)
  • Based on the type of cell, the global single use bioreactor (SUBs) market is categorized into mammalian cells, bacterial cells, yeast cells and other cells (insect and plant cells). (marketsandmarkets.com)
  • On the basis of molecule type, the global single use bioreactor market is categorized into monoclonal antibodies (mAbs), vaccines, gene-modified cells, stem cells, and other molecules (recombinant proteins, including growth factors & interferons, antisense, and RNA interference). (marketsandmarkets.com)
  • A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells. (nih.gov)
  • In these bioreactors cells are grown in a pre-sterilized, inflated chamber called cell bag bioreactor. (medgadget.com)
  • Furthermore, the opportunities and the threats to the development of Micro Bioreactors market Forecast period from 2017 to 2022. (openpr.com)
  • Finally, the report Global Micro Bioreactors Market 2017 describes Micro Bioreactors industry expansion game plan, the Micro Bioreactors industry data source, appendix, research findings and the conclusion. (openpr.com)
  • It will support the Allegro XRS 25 bioreactor, with further expansions planned for the mPath portfolio in 2017 and beyond. (medindia.net)
  • On the other hand, extractability and leachability issues regarding disposable components used in bioreactors and regulatory concerns related to SUBs are the major factors restraining the growth of this market. (marketsandmarkets.com)
  • Discover the iCELLis ® ​, a scalable line of disposable high-cell density bioreactors. (in-pharmatechnologist.com)
  • Increased demand for local production of drugs in various countries are easily achieved through use of these disposable cellbag bioreactors which is helping to adhere to the local regulations through flexible access to the products. (medgadget.com)
  • This week, researchers from Boyce Thompson Institute and Texas A&M University report in Plant Direct exciting new technology that may revolutionize the search for the perfect algal strain: Algal droplet bioreactors on a chip. (eurekalert.org)
  • The Micro Bioreactors report provides the past, present and future Micro Bioreactors industry Size, trends and the forecast information related to the expected Micro Bioreactors sales revenue, growth, Micro Bioreactors demand and supply scenario. (openpr.com)
  • Countries such as China and India are significantly contributing in the bioreactor market during the forecast period. (marketpublishers.com)
  • Asia-Pacific bioreactors market is anticipated to be the fast-growing market in the forecast period with a CAGR of 8.0% from 2023-2029. (visiongain.com)
  • Cellbag bioreactor chambers market is driven by increasing acceptance of these reactor chambers among small biopharmaceutical or start-ups owing to decent return on investment and ease of usage i.e. decrease in automation complexity are major factors contributing to the growth of cellbag bioreactor chambers market over the forecast period. (medgadget.com)
  • Cellbag bioreactor chambers market hindered by the concerns regarding leachables, extractables and stringent regulatory requirements for the cellbag bioreactors approvals may affect the market negatively over the forecast period. (medgadget.com)
  • The membrane bioreactor combines the advantages of membrane devices with the clean technology of biological air purification. (wur.nl)
  • This thesis proposes a simple submerge membrane bioreactor (sMBR) dynamic model that comprises physical and biological process behaviors. (inria.fr)
  • These bioreactors are commonly cylindrical, ranging in size from litres to cubic metres, and are often made of stainless steel. (wikipedia.org)
  • Plastic single-use bioreactors are of interest to biopharmaceutical drug manufacturers due to their significant environmental and cost benefits and flexibility over stainless steel bioreactors. (brighttalk.com)
  • Software sensors for bioreactors. (elsevier.com)
  • SCHOTT ViewPort™ for multi-use bioreactors feature a hermetic sealed optical window, which acts as a receptacle for optical sensors or spectrometers on the bioreactor for real-time process monitoring. (schott.com)
  • These cellbag bioreactors are attached with sensors that optically measures the level of O2 dissolved and pH of the culture medium. (medgadget.com)
  • When referring to this article, please cite it as A. Strand and N. Courtemanche, 'Impact of Agitator Design on Bioreactor Performance,' Pharmaceutical Technology Biologics and Sterile Drug Manufacturing eBook (May 2018). (pharmtech.com)
  • In December, 2010, Emerging Healthcare Solutions Inc. acquired a sublicense from Regenetech to use the bioreactor. (spaceref.com)
  • Cell growth in bioreactors depends on a wide range of environmental and physiological conditions such as substrate concentration. (wikipedia.org)
  • The bladder as a bioreactor: urothelium production and secretion of growth hormone into urine," Nature Biotechnology , vol. 16, no. 1, pp. 75-79, 1998. (hindawi.com)
  • Recent market study " Micro Bioreactors Market " analyses the crucial factors of the Micro Bioreactors market based on present industry situations, market demands, business strategies adopted by Micro Bioreactors market players and their growth scenario. (openpr.com)
  • After an early analysis of the business implications of the pandemic and its induced economic crisis, growth in the Multiple-use Bioreactors segment is readjusted to a revised 9.6% CAGR for the next 7-year period. (reportlinker.com)
  • They were dynamically cultured in the TPS bioreactor setup with adjustable growth chamber, media reservoir, and peristaltic pump. (nih.gov)
  • Membrane bioreactor (MBR) is a combination of membrane filtration techniques such as microfiltration and ultra filtration and suspended growth bioreactor. (automation.com)
  • Bioreactors enable the control over temperature, moisture, pH, oxygen, and stirring rate for optimal cell growth and productivity. (marketpublishers.com)
  • The factors contributing to the growth of the market are the growing technological advancements in bioreactor design, growing demand for therapeutically effective vaccines, and new product in development. (marketpublishers.com)
  • However, challenges associated with the use of bioreactors such as non-customizable and difficult to scale may hinder the global bioreactor market growth. (marketpublishers.com)
  • The global bioreactor market is analyzed on the basis of the geographical regions that are contributing significantly towards the growth of the market. (marketpublishers.com)
  • China bioreactor market is expected to be a major country due to rising R&D investment, and government initiatives to boost the growth of the market. (marketpublishers.com)
  • Created in collaboration with marine scientists, the IKA® BR 10 Bioreactor is a progressive step forward, with an interface that controls all of the photosynthetic variables of lighting, motion, pH value, and temperature. (prweb.com)
  • The bioreactor should provide optimum conditions, with respect to temperature, pH and substrate condition, for example, besides its basic function of containment. (lu.se)
  • Fermentor and Bioreactor features Allen-Bradley PLC. (thomasnet.com)
  • Fermentor/Bioreactor is available with 1.3-14 L capacities. (thomasnet.com)
  • The ability to control the substrate concentration is an important function of the bioreactor. (lu.se)
  • Recycle enables a higher concentration of microorganisms to be maintained in the bioreactor, which allows the reactor to run at much greater flow-rates and increases its efficiency. (edu.au)
  • This report isolates the Micro Bioreactors market based on the key players, Type, Application and Regions. (openpr.com)
  • The study of emerging Micro Bioreactors market segments and the existing market segments will help the readers in planning the business strategies. (openpr.com)
  • In the current market scenario, there is a growing demand for single-use bioreactor products. (marketsandmarkets.com)
  • On the basis of type, the single use bioreactor market is categorized into wave-induced SUBs, stirred-tank SUBs, bubble-column SUBs, and other bioreactors. (marketsandmarkets.com)
  • The U.K. is the largest market for membrane bioreactor in Europe. (automation.com)
  • Asia-Pacific is expected to be the fastest growing market due to the increasing adoption of advanced bioreactors by CROs to increase their manufacturing capabilities. (marketpublishers.com)
  • The market study of bioreactors market is incorporated by extensive primary and secondary research conducted by the research team at OMR. (marketpublishers.com)
  • Our study gives qualitative analysis of the bioreactors market. (visiongain.com)
  • Cellbag bioreactor chambers market has been segmented on the basis of application, scale, end user, and region. (medgadget.com)
  • Cellbag bioreactor chambers market is witnessing significant changes due to increasing buyer's interest in choosing single use cellbag bioreactors to retain control over manufacturing process. (medgadget.com)
  • Geographically, global cellbag bioreactor chambers market is classified into regions viz. (medgadget.com)
  • Kinetic Modelling, Estimation and Control in Bioreactors: An Overview. (elsevier.com)
  • Adaptive control of bioreactors. (elsevier.com)
  • A general solution to the linearizing control problem for a class of CST bioreactors. (elsevier.com)
  • a significant contribution to the problem of modelling, estimation and adaptive control of bioreactors. (elsevier.com)
  • The Thermo Scienti﫿c HyClone S.U.B. (Single-Use Bioreactor ) with BioNet control provides all the advantages of single-use bioprocessing with the power and 﫿exibility of DeltaV control . (environmental-expert.com)
  • Integrated control of bioreactors , bulk tanks, transfer lines and downstream processing equipment. (environmental-expert.com)
  • They saw that, unlike in the control and sham groups, the regenerating limbs of the bioreactor-treated frogs were thicker with more developed bones, innervation, and vascularization. (eurekalert.org)
  • The Ranger Solo from Stratophase Ltd. , Romsey, U.K., lets you perform real-time, in-process monitoring for single-use bioreactors to control feeding to the reactor and increase yields of fully functional biologics. (sensorsmag.com)
  • The architecture makes plug-and-play connectivity a reality, while providing access to features of Pall bioreactors that other commercial control options do not allow. (medindia.net)
  • We offer solid constructed solutions for bioreactor gas and liquid flow control. (bronkhorst.com)
  • This paper describes how the Yokogawa BR1000 bioreactor can be used to automate through real-time sensing and improve productivity through accurate and efficient glucose control. (yokogawa.com)
  • A benefit of using the BIOSTAT® RM TX bioreactor in combination with the Flexsafe® RM TX bag for cell culture is the possibility for walk-away monitoring and culture control. (ecmconnection.com)
  • The bioreactors are equipped with either a simple manual control or more complex, fully automated, PLC control. (bronkhorst.com)
  • Flow controllers play a significantly important role in the process control of Bioreactors. (bronkhorst.com)
  • The bioreactor device triggered very complex downstream outcomes that bioengineers cannot yet micromanage directly. (eurekalert.org)
  • Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies. (bioprocessintl.com)
  • Principles of Membrane Bioreactors for Wastewater Treatmentᅠdescribes the state-of-the-art of MBR technology, principles of MBR and design and operation of plants. (environmental-expert.com)
  • For example, Veolia Water Solutions & Technologies (US based membrane bioreactor manufacturer) has came into an agreement with Shell Canada (Canadian based membrane bioreactor company) to design and manufacture a waste water treatment equipment to recover the water used for steam production at Shell's Carmon Creek project. (automation.com)
  • Herein, we describe a scalable, low-cost protocol for expanding hiPSCs as aggregates in a lab-scale bioreactor. (springer.com)
  • The Applikon Biotechnology team was developing a small laboratory-scale bioreactor that would be flexible and ideal for small-scale operations and be able to generate more data, save time, and take up less bench space all the while producing scalable results. (coleparmer.com)
  • In the UK Wehrle has designed and built a membrane bioreactor to treat rendering plant effluent at Argent By-Products Group Ltd at Motherwell. (edie.net)
  • In a bioreactor with recycle the effluent emerging from the reactor is fed into a settling unit. (edu.au)
  • Photo bioreactors create a natural environment to grow microorganisms for scientific purposes such as for drug discovery or translational science. (ika.com)
  • Bioreactors sometimes employ a permeable membrane, such as a microfiltration membrane, to physically retain microorganisms inside the reactor. (edu.au)
  • As per 12th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production report, industry demands more innovations in bioreactor technology with single-use bioreactors requiring most needed innovation area. (openpr.com)
  • 100/mm2) in the polymer matrix and enhanced transport of nutrient and oxygen through advection represent the key advantages of the microfabricated bioreactors to the traditional foam based scaffolds. (nsti.org)
  • Compared with other mammalian species (pig, goat, sheep, and cow) that are currently being studied as bioreactors, rabbits offer many advantages: high fertility, easy generation of transgenic founders and offspring, insensitivity to prion diseases, relatively high milk production, and no transmission of severe diseases to humans. (hindawi.com)
  • N2 is used to calibrate the Oxygen sensor (pO2) and to reduce the O2-content in the bioreactor at the beginning of the process. (bronkhorst.com)
  • A bioreactor is usually controlled by checking the partial oxygen pressure pO2 and the pH in the suspension. (bronkhorst.com)
  • Dynamic culture in TPS bioreactor not only resulted in high cell viability throughout the femur graft, but also showed early signs of stem cell differentiation through increased expression of osteogenic genes and proteins, consistent with our previous models of smaller bone constructs. (nih.gov)
  • To take advantage of known physiological drivers of thrombopoiesis, we have developed a microfluidic human platelet bioreactor that recapitulates bone marrow stiffness, extracellular matrix composition, micro-channel size, hemodynamic vascular shear stress, and endothelial cell contacts, and it supports high-resolution live-cell microscopy and quantification of platelet production. (bloodjournal.org)
  • The bioreactor has no internal moving parts, which minimizes forces that might damage the delicate cell cultures. (spaceref.com)
  • A case study on extractables from single-use bioreactors and impact on cell culture performance will be presented. (brighttalk.com)
  • One of the most popular types of single-use bioreactors uses a rocking platform in place of a traditional shaft and agitator assembly to aerate and mix cell culture material within a presterilized, single-use plastic bag (1). (bioprocessintl.com)
  • Versatile and portable, the Bose® 3D CulturePro bioreactor is built for multiple experiment usage, completely biocompatible and can be moved in and out of standard cell incubators. (news-medical.net)
  • To establish function, we perfused and ventilated cell-seeded constructs in a bioreactor simulating the physiologic environment of developing lung. (medgadget.com)
  • The culture in the cell bags are agitated by shaking the cellbag attached to the bioreactor tray. (medgadget.com)
  • Such distant cell "bioreactors" could modulate the observed post-injury pro-inflammatory environment and lead to neuroprotection. (nih.gov)