Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Idiopathic Pulmonary Fibrosis: A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Lung Diseases, Interstitial: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.Bronchoalveolar Lavage Fluid: Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Myofibroblasts: Spindle-shaped cells with characteristic CONTRACTILE PROTEINS and structures that contribute to the WOUND HEALING process. They occur in GRANULATION TISSUE and also in pathological processes such as FIBROSIS.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Cystic Fibrosis Transmembrane Conductance Regulator: A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)Alveolitis, Extrinsic Allergic: A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Endomyocardial Fibrosis: A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Peplomycin: An antineoplastic agent derived from BLEOMYCIN.Mice, Inbred C57BLRespiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.Transforming Growth Factor beta1: A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Pulmonary Emphysema: Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.Antibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Sarcoidosis, Pulmonary: Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)Bronchoalveolar Lavage: Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.Hermanski-Pudlak Syndrome: Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.Asbestosis: A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.Pyridones: Pyridine derivatives with one or more keto groups on the ring.Retroperitoneal Fibrosis: A slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.Lung Diseases: Pathological processes involving any part of the LUNG.Macrophages, Alveolar: Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.Pulmonary Surfactant-Associated Protein C: A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.Pneumocytes: Epithelial cells that line the PULMONARY ALVEOLI.Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Asbestos: Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.Idiopathic Interstitial Pneumonias: A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.Cryptogenic Organizing Pneumonia: An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Vital Capacity: The volume of air that is exhaled by a maximal expiration following a maximal inspiration.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Lung Injury: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Pulmonary Diffusing Capacity: The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the BLOOD-AIR BARRIER.Respiratory Mucosa: The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Pneumonia: Infection of the lung often accompanied by inflammation.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Image-Guided Biopsy: Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Silicon Dioxide: Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Sarcoidosis: An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.Silicosis: A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.HSP47 Heat-Shock Proteins: Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Respiratory System Agents: Drugs used for their effects on the respiratory system.Smad3 Protein: A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.Total Lung Capacity: The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.Biopsy, Large-Core Needle: The use of needles usually larger than 14-gauge to remove tissue samples large enough to retain cellular architecture for pathology examination.Connective Tissue Growth Factor: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Biopsy, Fine-Needle: Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.Mucin-5B: A gel-forming mucin that is predominantly expressed by submucosal glands of airway tissues and the SUBLINGUAL GLAND. It is one of the principal components of high molecular weight salivary mucin.Pleural DiseasesRadiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Pulmonary Surfactant-Associated Protein A: An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Oral Submucous FibrosisSensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Dyspnea: Difficult or labored breathing.Epithelial-Mesenchymal Transition: Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Liver Cirrhosis, Experimental: Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Smad2 Protein: A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. It regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Respiratory Aspiration: Inhaling liquid or solids, such as stomach contents, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Expectorants: Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Bronchi: The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Pneumoconiosis: A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Scleroderma, Diffuse: A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Smad Proteins: A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.Telomerase: An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.Interleukin-13: A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.Paraquat: A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.Forced Expiratory Volume: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Hepatic Stellate Cells: Perisinusoidal cells of the liver, located in the space of Disse between HEPATOCYTES and sinusoidal endothelial cells.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Gammaherpesvirinae: A subfamily of HERPESVIRIDAE characterized by variable reproductive cycles. The genera include: LYMPHOCRYPTOVIRUS and RHADINOVIRUS.Ureteral Obstruction: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.Therapeutic Irrigation: The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.Bronchoscopy: Endoscopic examination, therapy or surgery of the bronchi.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Emphysema: A pathological accumulation of air in tissues or organs.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Scleroderma, Limited: The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.Pleura: The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.Pulmonary Surfactant-Associated Protein D: An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.Sentinel Lymph Node Biopsy: A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The sentinel lymph node is the first lymph node to receive drainage from a neoplasm.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Instillation, Drug: The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.Leukocyte Elastase: An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 220.127.116.11.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Acute Disease: Disease having a short and relatively severe course.Fibronectins: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)Cell Line: Established cell cultures that have the potential to propagate indefinitely.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Lung Neoplasms: Tumors or cancer of the LUNG.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Matrix Metalloproteinase 7: The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression.Chemokine CCL17: A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Peritoneal Fibrosis: Disorder characterized by a wide range of structural changes in PERITONEUM, resulting from fibrogenic or inflammatory processes. Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Asbestos, Serpentine: A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)Primary Graft Dysfunction: A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.Acetylcysteine: The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Bronchiectasis: Persistent abnormal dilatation of the bronchi.Microscopic Polyangiitis: A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.Rats, Inbred F344Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Chemokine CXCL5: A CXC chemokine that is predominantly expressed in EPITHELIAL CELLS. It has specificity for the CXCR2 RECEPTORS and is involved in the recruitment and activation of NEUTROPHILS.Radiation Injuries, Experimental: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Wound Healing: Restoration of integrity to traumatized tissue.
Although lung biopsy is usually not necessary, the presence of asbestos bodies in association with pulmonary fibrosis ... Lung cancer, mesothelioma, pleural fibrosis, pulmonary heart disease. Usual onset. ~10-40 years after long-term exposure[ ... fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. ... CT or high-resolution CT (HRCT) are more sensitive than plain radiography at detecting pulmonary fibrosis (as well as any ...
... and pulmonary inclusions as seen with cystic fibrosis. It can be dangerous to biopsy a number of types of tumor in which the ... pulmonary inclusions, or gastrointestinal duplications) due to outflow obstructions or narrowings, or abnormal connections, may ... biopsy or surgical exploration/excision in an attempt to avoid such severe complications. ... or by a pathologist after examination of the tissue from a biopsy or a surgical specimen. ...
When fibrosis develops in chronic hypersensitivity pneumonitis, the differential diagnosis in lung biopsies includes the ... idiopathic pulmonary fibrosis), are very poor and the treatments of little help. This contrasts the prognosis (and treatment) ... Lung biopsies can be diagnostic in cases of chronic hypersensitivity pneumonitis, or may help to suggest the diagnosis and ... Thus, a lung biopsy, in some cases, may make a decisive difference. Hypersensitivity pneumonitis may also be called many ...
These include pulmonary fibrosis which can occur when the lung is inflamed for a long period of time. Fibrosis in the lung ... Once a cancer is identified it is staged using scans such as a CT scan and a sample of tissue (a biopsy) is taken. Cancers may ... A pulmonary embolism is a blood clot that becomes lodged in the pulmonary arteries. The majority of emboli arise because of ... Pulmonary hypertension describes an increased pressure at the beginning of the pulmonary artery that has a large number of ...
... idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India". Lung India. 32 (5 ... Lung biopsy also plays a role in the diagnosis of interstitial lung disease. Any approach to lung biopsy risks causing a ... A lung biopsy is an interventional procedure performed to diagnose lung pathology by obtaining a small piece of lung which is ... A lung biopsy can be performed percutaneously (through the skin, typically guided by a CT Scan), via bronchoscopy with ...
The diagnosis can be confirmed by lung biopsy. A videoscopic assisted thoracoscopic wedge biopsy (VATS) under general ... There is no known cure for the scars and damage in the lung due to pulmonary fibrosis. Symptoms of pulmonary fibrosis are ... Misdiagnosis is common because, while overall pulmonary fibrosis is not rare, each individual type of pulmonary fibrosis is ... of pulmonary fibrosis]". Mayo Foundation for Medical Education and Research. Retrieved 26 July 2014. "Pulmonary Fibrosis". ...
In later stages hilar lymphadenopathy, intersitial pulmonary fibrosis and pleural thickening. Berylliosis is an occupational ... documented beryllium sensitivity and granulomatous inflammation on lung biopsy. Given the invasive nature of a lung biopsy ... pulmonary function testing and radiography. Once clinical symptoms or significant abnormalities in pulmonary function testing ... Eventually, the final outcome is fibrosis of the lung. Several studies have shown that there is a genetic component to ...
On 30 December 2001 Sherlock died in London from pulmonary fibrosis, two after her golden wedding anniversary. Her daughter ... She pioneered the use of needle liver biopsy, which had been used purely as a research tool, based on the technique of Sir John ... She was awarded her MD with a thesis on The Liver in Disease: with special reference to aspiration liver biopsy, receiving a ... Sherlock, S. "Aspiration liver biopsy. Technique and diagnostic application". The Lancet, 1945; 2: pp. 397-401 D. Doniach, I.M ...
Idiopathic pulmonary fibrosis
Small biopsies, such as those obtained via transbronchial lung biopsy (performed during bronchoscopy) are usually not ... 2011). "Familial pulmonary fibrosis is the strongest risk factor for idiopathic pulmonary fibrosis". Respir Med. 105 (12): 1902 ... Canine Pulmonary Fibrosis. Akcchf.org. Retrieved 2013-04-11.  "Research Demonstrates Reversal Of Pulmonary Fibrosis With ... The number of published studies on the role of pulmonary rehabilitation in idiopathic pulmonary fibrosis is small, but most of ...
Usual interstitial pneumonia
Pneumoconiosis Silicosis Asbestosis Idiopathic pulmonary fibrosis Pulmonary fibrosis Emphysema Travis WD, King TE, Bateman ED, ... pattern of the fibrosis. Appearance of honeycomb change in a surgical lung biopsy at low magnification. The dilated spaces seen ... In case of idiopathic pulmonary fibrosis, certain medications like pirfenidone can help slow the progression. Lastly, lung ... Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline". American Journal of Respiratory ...
For patients with pulmonary involvement, the most serious complication of this syndrome is pulmonary fibrosis and subsequent ... creatine kinase Anti-Jo-1 antibody testing Electromyography Muscle biopsy Pulmonary function testing Lung biopsy In certain ... Prognosis is largely determined by the extent of pulmonary damage. Bergoin, C.; Bure M; Tavernier JY; Lamblin C; Maurage CA; ... This anti-histidyl tRNA Synthetase antibody is commonly seen in patients with pulmonary manifestations of the syndrome. The ...
"Pulmonary hyalinizing granuloma" is a lesion characterized by keloid-like fibrosis in the lung, and is not granulomatous. ... The finding of food particles in lung biopsies is diagnostic. Necrotizing granulomas can develop in patients with rheumatoid ... In the lungs, this scarring can cause a condition known as pulmonary fibrosis that impairs breathing. In the heart, it can lead ... The diagnosis is established by finding Pneumocystis yeasts within the granulomas on lung biopsies. Aspiration pneumonia is ...
High-resolution computed tomography
While HRCT may be able to identify pulmonary fibrosis, it may not always be able to further categorize the fibrosis to a ... Where HRCT is unable to reach a definitive diagnosis, it helps locate an abnormality, and so helps planning a biopsy, which may ... Gotway, M. B; Freemer, M. M; King, T. E (1 June 2007). "Challenges in pulmonary fibrosis · 1: Use of high resolution CT ... HRCT is used for diagnosis and assessment of interstitial lung disease, such as pulmonary fibrosis, and other generalized lung ...
Flock worker's lung
"Pulmonary hyalinizing granuloma" is a lesion characterized by keloid-like fibrosis in the lung, and is not granulomatous. ... The finding of food particles in lung biopsies is diagnostic.. Rheumatoid arthritisEdit. Necrotizing granulomas can develop ... In the lungs, this scarring can cause a condition known as pulmonary fibrosis that impairs breathing. In the heart, it can lead ... These include lymphocytes, neutrophils, eosinophils, multinucleated giant cells, fibroblasts and collagen (fibrosis). The ...
It is defined as diffuse interstitial pulmonary fibrosis secondary to asbestos exposure. It initially affects the lung bases ... A biopsy is needed to confirm a diagnosis of malignant mesothelioma. Mesothelioma has a poor prognosis, with most patients ... Asbestos-related diseases include non-malignant disorders such as asbestosis (pulmonary fibrosis due to asbestos), diffuse ... Asbestos-related fibrosis is progressive because it continues to progress in the lung even if no further asbestos is inhaled. ...
Lung biopsy is not part of the routine diagnostic workup of tropical pulmonary eosinophilia. The dramatic response to a ... as delay before treatment may lead to progressive interstitial fibrosis and irreversible impairment. The condition of marked ... Tropical pulmonary eosinophilia is a rare, but well recognised, syndrome characterised by pulmonary interstitial infiltrates ... Tropical (pulmonary) eosinophilia, or TPE, is characterized by coughing, asthmatic attacks, and an enlarged spleen, and is ...
BHL with pulmonary infiltrates Stage III: pulmonary infiltrates without BHL Stage IV: fibrosis. Use of the Scadding scale only ... CT-guided biopsy, mediastinoscopy, open lung biopsy, bronchoscopy with biopsy, endobronchial ultrasound, and endoscopic ... including improvement in pulmonary function, remodeling of lung parenchyma and prevention of pulmonary fibrosis in separate ... In some persons, it can progress to pulmonary fibrosis and death. About half of cases resolve without treatment or can be cured ...
Interstitial lung disease
Prolonged ILD may result in pulmonary fibrosis, but this is not always the case. Idiopathic pulmonary fibrosis is interstitial ... In cases where a lung biopsy is indicated, a trans-bronchial biopsy is usually unhelpful, and a surgical lung biopsy is often ... Lower lung predominance Idiopathic pulmonary fibrosis, pulmonary fibrosis associated with connective tissue diseases, ... Pulmonary edema Chronic: Idiopathic pulmonary fibrosis, connective tissue associated interstitial lung diseases, asbestosis, ...
Transfusion transmitted virus
Viral infection in acute exacerbation of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. Maggi F, Pifferi M, ... "Detection and phylogenetic analysis of Torque Teno Virus in salivary and tumor biopsy samples from head and neck carcinoma ... The presence of this virus in acute lung injury and exacerbations of idiopathic lung fibrosis has been reported. Increased ...
Acute interstitial pneumonitis
... but it is distinguished from the chronic forms of interstitial pneumonia such as idiopathic pulmonary fibrosis. The most common ... Other diagnostic tests are useful in excluding other similar conditions, but history, x-ray, and biopsy are essential. These ... Hamman L.; Rich A.R. (1944). "Acute diffuse interstitial fibrosis of the lungs". Bull. Johns Hopkins Hosp. 74: 177-212. Bouros ... Hamman, L; Rich AR (1935). "Fulminating diffuse interstitial fibrosis of the lungs". Transactions of the American Clinical and ...
Rheumatoid lung disease
This is more common in cases of bronchiolitis obliterans, pulmonary fibrosis, or pulmonary hypertension. Most complications are ... 1961, Cudkowicz described the first pulmonary function tests and lung biopsies were done in RA patients. RA is a complex and ... Rheumatoid lung disease is characterized by pleural effusion, pulmonary fibrosis, lung nodules and pulmonary hypertension. ... The diagnosis of rheumatoid lung disease is based on evaluation of pulmonary function, radiology, serology and lung biopsy. ...
On radiological imaging, pulmonary infiltrates induced by amiodarone are usually high in attenuation. On biopsy, the presence ... Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis. Semin Oncol. ... Pulmonary = lung. Pulmonary toxicity = pulmonary injury = lung injury = lung toxicity. And instead of pulmonary toxicity (a ... Pulmonary toxicity is the medical name for side effects on the lungs. Although most cases of pulmonary toxicity in medicine are ...
... pulmonary fibrosis, pulmonary hypertension) Physical diagnostics are as important as in the other fields of medicine. ... endobronchial and transbronchial biopsy and epithelial brushing Chest X-rays CT scanning Scintigraphy and other methods of ... emphysema and pulmonary fibrosis). When this is insufficient, the patient might require mechanical ventilation. Pulmonary ... This is believed by many to be the first scientific description of pulmonary circulation. Although pulmonary medicine only ...
Pulmonary alveolar microlithiasis
Many authors argue that this pattern precludes the need for a lung biopsy in most cases. After PAM is diagnosed in a given ... lung inflammation and fibrosis, elevated pressures in the lung blood vessels, and respiratory failure ensue, usually in middle ... causing pulmonary alveolar microlithiasis". Proc Am Thorac Soc. 3: A102. Hagiwara, K; Johkoh, T; Tachibana, T (2009). Pulmonary ... Pulmonary alveolar microlithiasis (PAM) is a rare, inherited disorder of lung phosphate balance that is associated with small ...
These include pulmonary fibrosis which can occur when the lung is inflamed for a long period of time. Fibrosis in the lung ... Once a cancer is identified it is staged using scans such as a CT scan and a sample of tissue (a biopsy) is taken. Cancers may ... A pulmonary embolism is a blood clot that becomes lodged in the pulmonary arteries. The majority of emboli arise because of ... Congenital disorders include cystic fibrosis, pulmonary hypoplasia (an incomplete development of the lungs)congenital ...
A bone marrow biopsy will reveal collagen fibrosis, replacing the marrow that would normally occupy the space. ... These cases are associated with hypertension in the pulmonary arteries.. The bone marrow in a typical case is hypercellular ... Diagnosis is made on the basis of bone marrow biopsy. Fibrosis grade 2 or 3 defines overt PMF whereas grade 0 or 1 defines ... The primary feature of primary myelofibrosis is bone marrow fibrosis, but it is often accompanied by: *Abdominal fullness ...
Although resting pulmonary hypertension appears to be unusual in LAM, pulmonary arterial pressure often rises with low levels ... Video-assisted thoracoscopic lung biopsy is the most definitive technique, but transbronchial biopsy has a yield of over 50% ... Chyle does not generally cause pleural inflammation or fibrosis. Small stable chylous effusions rarely require intervention ... Pulmonary function testing in patients with LAM may be normal or may reveal obstructive, restrictive or mixed patterns. ...
These include pulmonary fibrosis which can occur when the lung is inflamed for a long period of time. Fibrosis in the lung ... Once a cancer is identified it is staged using scans such as a CT scan and a sample of tissue (a biopsy) is taken. Cancers may ... "Secondary pulmonary lobule". radiopaedia.org. Retrieved 10 August 2019.. *^ a b c d e f g h i Stanton, Bruce M.; Koeppen, Bruce ... A pulmonary embolism is a blood clot that becomes lodged in the pulmonary arteries. The majority of emboli arise because of ...
Hematopoietic stem cell transplantation
In addition to inflammation, chronic graft-versus-host disease may lead to the development of fibrosis, or scar tissue, similar ... The most common severe adverse reactions were pulmonary edema/deep vein thrombosis, splenic rupture, and myocardial infarction ... researchers cannot detect HIV in the transplant recipient's blood or in various biopsies of his tissues. Levels of HIV- ...
Non-small-cell lung carcinoma
People with severe pulmonary fibrosis and severe emphysema with a life expectancy ,1 year should be considered poor candidates ... This is most often the case when a pathologist examines a small amount of malignant cells or tissue in a cytology or biopsy ... small-cell lung carcinoma and broncho-pulmonary carcinoid tumors. With TNM staging, the cancer is classified based on the ...
Surgical biopsy with histological identification of the vascular or lymphatic proliferation within a generous section of the ... which leads to resorption and replacement of bone with angiomas and/or fibrosis. Current treatments are experimental only. The ... from the mid-1950s through the early 1960s conducted and reported the classical clinicopathological investigations of pulmonary ... Positive biopsy with the presence of angiomatous tissue Absence of cellular atypia Minimal or no osteoblastic response or ...
Upper gastrointestinal series
... fibrosis, wall thickening, loss of haustration, and stenosis in Barium X-rays. Anisakiasis is demonstrated by Barium X-rays ... Liver biopsy. *Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal ... Pulmonary CT. *Head CT. *Thyroid CT. *Whole body imaging *Full-body CT scan ...
H&E stain of a biopsy of the normal esophageal wall, showing the stratified squamous cell epithelium of the esophageal wall. ... From the bifurcation of the trachea downwards, the esophagus passes behind the right pulmonary artery, left main bronchus, and ... A Schatzki ring is fibrosis at the gastro-esophageal junction. Strictures may also develop in chronic anemia, and Plummer- ... During an endoscopy, a biopsy may be taken. If cancer of the esophagus is being investigated, other methods, including a CT ...
... pulmonary fibrosis). It can cause disease in those with normal immune function, although immunosuppression increases the ... exudates and biopsies. Histopathological study with Gomori methenamine silver (GMS) stain or hematoxylin and eosin (H&E) stain ... Queiroz-Telles, Flavio; Escuissato, Dante (December 2011). "Pulmonary Paracoccidioidomycosis". Seminars in Respiratory and ... Both pulmonary and extrapulmonary involvement is common. ...
Special tests (blood tests, radiology, scans, a biopsy, etc.) also allow a hypothesis to be tested. These special tests are ... cystic fibrosis) and obstructive diseases (in which the lung volume is normal but the air flow rate is impeded; e.g., emphysema ... pulmonary embolism *Hampton hump. *Westermark sign. *pulmonary edema *Kerley lines. *Hamman's sign ...
Lung biopsy:risks *^ Hitchens, TK; Ye, Q; Eytan, DF; Janjic, JM; Ahrens, ET; Ho, C (Apr 2011). "19F MRI detection of acute ... The term chronic rejection initially described long-term loss of function in transplanted organs via fibrosis of the ... and the patient eventually succumbs to pulmonary insufficiency or secondary acute infection. ... Tissue biopsy is restricted, however, by sampling limitations and risks/complications of the invasive procedure. ...
Primary biliary cholangitis
Liver biopsyEdit. On microscopic examination of liver biopsy specimens, PBC is characterized by interlobular bile duct ... Stage 2 - Periportal Stage: Enlarged triads; periportal fibrosis and/or inflammation. Typically characterized by the finding of ... pulmonary, or dermatological condition, suggesting shared genetic and immune abnormalities. Common associations include ... A liver biopsy may help, and if uncertainty remains as in some patients, an endoscopic retrograde cholangiopancreatography ( ...
Positron emission tomography
1986). "Stereotaxic biopsy of the brain under MR imaging control". AJNR American Journal of Neuroradiology. 7 (1): 161-163. ... May 2008). "Estimation of the radiation dose from CT in cystic fibrosis". Chest. 133 (5): 1289-91; author6 reply 1290-1. doi: ... Pulmonary. *Computed tomography of the head. *Quantitative computed tomography. *Spiral computed tomography ...
ന്യുമോണിയ - വിക്കിപീഡിയ
Idiopathic Pulmonary Fibrosis, IPF), അനിയത അന്തരാളകലാ ന്യുമോണിയ (Nonspecific Interstitial Pneumonia, NSIP), ഗുപ്തജന്യ ... comparative validation using immediate post-mortem lung biopsies. Thorax. 1999 Oct;54(10):867-73. PMID: 10491448. ... fibrosis). External agents/. occupational. lung disease. Pneumoconiosis (Asbestosis, Baritosis, Bauxite fibrosis, Berylliosis, ... 16.0 16.1 16.2 16.3 16.4 Simon HB (2005).Infectious Disease:XX:Pneumonia and Other Pulmonary Infections.in David C. Dale, ...
Biopsies. Extracardiac biopsies of tissues of the kidney, liver, peripheral nerve, or abdominal fat can be used to ... Amyloid deposits in biopsy samples are confirmed through the use of Congo red dye, which produces a green birefringence when ... For light-chain amyloidosis patients, bone marrow biopsies could be conducted to determine baseline percentage of plasma cells ... This test is more invasive and would be performed after inconclusive endomyocardial biopsy samples. ...
idiopathic pulmonary fibrosis. *connective tissue disease. *sarcoidosis. *radiation fibrosis. *asbestosis. *lymphangitis ... high-resolution CT of the chest is usually required and sometimes a lung biopsy. The following features should be noted: *type ... Enlargement of the right descending pulmonary artery can indirectly reflect changes of pulmonary hypertension, with a size ... "Diagnosis of pulmonary hypertension from radiographic estimates of pulmonary arterial size". Thorax. 43 (2): 127-31. doi: ...
... pulmonary hypertension, pulmonary fibrosis and scleroderma renal crisis. People with scleroderma are also at a heightened risk ... Diagnosis is typically based on a person's symptoms and may be supported by a skin biopsy or blood tests. While there is no ... Nephrogenic systemic fibrosis, a condition usually caused by kidney failure that causes fibrosis (thickening) of the tissues. ... Pulmonary: progressive worsening of shortness of breath, chest pain (due to pulmonary artery hypertension) and dry, persistent ...
A kidney biopsy may also be used as a more specific and invasive test method. A study of a sample's anatomical pathology may ... Pulmonary edema: the loss of proteins from blood plasma and the consequent fall in oncotic pressure causes an abnormal ... In addition, imaging of the kidneys (for structure and presence of two kidneys) is sometimes carried out, and/or a biopsy of ... A solution of 25% albumin is used that is administered for only 4 hours in order to avoid pulmonary edema. ...
Diagnostic tests - Brain biopsy (T), C-reactive protein, CSF tap test (T), CT pulmonary angiogram, Des-gamma carboxyprothrombin ... Nephrogenic systemic fibrosis, Neuroleptic malignant syndrome (T), Neuromyelitis optica (T), Neurosarcoidosis, Neutropenia, ... Pulmonary edema, Pulmonary embolism (T), Pulmonary hypertension, Pulseless electrical activity (Talk), Pyroluria, Purpura ... Liver biopsy (was redirect, got onto DYK), Nissen fundoplication, Outpatient parenteral antibiotic therapy (T), ...
The cause for the myocarditis can be only diagnosed by a biopsy. Endomyocardial biopsy samples are assessed for histopathology ... The gold standard is the biopsy of the myocardium, in general done in the setting of angiography. A small tissue sample of the ... Electrocardiogram, blood troponin, heart MRI, heart biopsy. Treatment. Medications, implantable cardiac defibrillator, ... Endomyocardial biopsy specimen with extensive eosinophilic infiltrate involving the endocardium and myocardium (hematoxylin and ...
Combined pulmonary fibrosis and emphysema. *Pulmonary edema. *Löffler's syndrome/Eosinophilic pneumonia. *Respiratory ... For cases suspicious enough to proceed to biopsy, small biopsies can be obtained by core needle or bronchoscopy are commonly ... fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. ... A lung nodule or pulmonary nodule is a relatively small focal density in the lung. A solitary pulmonary nodule (SPN) or coin ...
Primary biliary cirrhosis, ulcerative colitis, Crohn's disease, diabetes mellitus, Pulmonary fibrosis. ... Biopsy. Biopsy of the cartilage tissue (for example, ear) may show tissue inflammation and destruction, and may help with ... Pulmonary function tests. It is useful to do a full set of pulmonary function tests, including inspiratory and expiratory ... Pulmonary function tests (flow-volume loops) provide a useful noninvasive means of quantifying and following the degree of ...
Tuberkulosis, ang malayang ensiklopedya
Textbook of pulmonary and critical care medicine. New Delhi: Jaypee Brothers Medical Publishers. pa. 549. ISBN 978-93-5025-073- ... Ang pagkakapinsala ng tisyu at necrosis ay madalas na binabalanse ng pagpapagaling at fibrosis. Ang naapektuhan na tisyu ay ... o ang biopsy tisyu). Gayun pa man, ang mahirap na culture process para sa mabagal na lumaking organismo na maaaring tumagal ng ... Textbook of pulmonary and critical care medicine. New Delhi: Jaypee Brothers Medical Publishers. pa. 525. ISBN 978-93-5025-073- ...
How do lung biopsies help diagnose idiopathic pulmonary fibrosis (IPF)?
... ANSWER The best way for your doctor to diagnose IPF is ... How can oxygen therapy help treat idiopathic pulmonary fibrosis (IPF)? * How can pulmonary rehab help treat idiopathic ... How do exercise tests help diagnose idiopathic pulmonary fibrosis (IPF)? NEXT QUESTION: What can make me feel better if I have ... What medications may keep your idiopathic pulmonary fibrosis (IPF) from getting worse? ...
Idiopathic Pulmonary Fibrosis Diagnosis
The diagnosis of idiopathic pulmonary fibrosis (IPF) typically involves questioning about medical history and examinations to ... Lung Biopsy. Video-assisted thoracoscopic surgery (VATS) is a technique used to obtain a biopsy of the lung tissue, which may ... Idiopathic Pulmonary Fibrosis Diagnosis. News-Medical. https://www.news-medical.net/health/Idiopathic-Pulmonary-Fibrosis- ... The diagnosis of idiopathic pulmonary fibrosis (IPF) typically involves questioning about medical history and examinations to ...
Idiopathic pulmonary fibrosis (IPF) is a rare lung disease that causes scar tissue to grow inside your lungs. Learn more about ... Biopsy. The doctor removes small pieces of your lung tissue and looks at them under a microscope. This may be done with surgery ... Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis - Idiopathic Pulmonary Fibrosis (IPF) * Pulmonary Fibrosis ... Pulmonary Fibrosis Treatment What Is Idiopathic Pulmonary Fibrosis (IPF)?. Idiopathic pulmonary fibrosis (IPF) is a serious ...
Idiopathic Pulmonary Fibrosis (IPF) Among Dental Personnel | NIOSH | CDC
Surgical lung biopsy. *Additional diagnostic tests to exclude other lung diseases. *Limited treatment options are available for ... Idiopathic pulmonary fibrosis (IPF) is most often diagnosed in people aged 50-60 years. More men than women are diagnosed with ... Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease without a known cause. Typical symptoms include ... Idiopathic pulmonary fibrosis in United States automated claims. Incidence, prevalence, and algorithm validation. Am J Respir ...
Medical Sciences | Free Full-Text | Prognosis and Follow-Up of Idiopathic Pulmonary Fibrosis | HTML
Idiopathic pulmonary fibrosis (IPF), a devastating progressive interstitial lung disease (ILD) with no known cause, is the most ... It is possible to detect it with a lung biopsy . Finding lots of fibroblast foci in different sites of surgical lung biopsy ... Clinical features and outcomes in combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis. Chest 2013, 144, ... Idiopathic pulmonary fibrosis is characterized by pulmonary function tests (PFT) disorders with a typical restrictive pattern ...
Pulmonary Fibrosis / Interstitial Lung Disease | Digital Naturopath
A physical examination, chest X-ray, pulmonary function tests, bronchoscopy, bronchoalveolar lavage, lung biopsy and blood ... Pulmonary Fibrosis. Pulmonary Fibrosis (PF) is a disease of inflammation that results in scarring, or fibrosis, of the lungs. ... The terms interstitial lung disease, pulmonary fibrosis and interstitial pulmonary fibrosis are often used to describe the same ... Absence of pulmonary fibrosis. Pulmonary Fibrosis / Interstitial Lung Disease suggests the following may be present. Autoimmune ...
Idiopathic pulmonary fibrosis: MedlinePlus Medical Encyclopedia
Idiopathic pulmonary fibrosis (IPF) is scarring or thickening of the lungs without a known cause. ... Idiopathic pulmonary fibrosis. www.nhlbi.nih.gov/health-topics/idiopathic-pulmonary-fibrosis. Accessed January 13, 2020. ... Idiopathic diffuse interstitial pulmonary fibrosis; IPF; Pulmonary fibrosis; Cryptogenic fibrosing alveolitis; CFA; Fibrosing ... Pulmonary Fibrosis Foundation -- www.pulmonaryfibrosis.org/life-with-pf/support-groups. *American Lung Association -- www.lung. ...
Procurement and Analysis of Specimens From Individuals With Pulmonary Fibrosis - Full Text View - ClinicalTrials.gov
Pulmonary Fibrosis. Lung Biopsy (Clinically-Indicated). Hereditary Pulmonary Fibrosis. Healthy Volunteer. HV. ... Idiopathic pulmonary fibrosis (defined by either an open lung biopsy demonstrating pulmonary fibrosis and/or HRCT scan findings ... Familial pulmonary fibrosis (defined as idiopathic pulmonary fibrosis in two or more first-degree relatives) ... extra-pulmonary biopsies, or post-mortem examination from subjects with pulmonary fibrosis. In addition, blood, genomic DNA, ...
PatientsLikeMe | Pulmonary fibrosis symptoms, treatments & patient forums | PatientsLikeMe
Pulmonary Rehabilitation, and N-Acetylcysteine NAC to treat their PF and its symptoms. ... Pulmonary fibrosis: Find the most comprehensive real-world symptom and treatment data on PF at PatientsLikeMe. 453 patients ... 2 evaluations from pulmonary fibrosis patients report major effectiveness of Lung Biopsy for idiopathic pulmonary fibrosis (33 ... 0 evaluations from pulmonary fibrosis patients report slight effectiveness of Lung Biopsy for idiopathic pulmonary fibrosis (0 ...
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. ...
Surgical lung biopsy specimens demonstrating UIP pattern. (A) Scanning power microscopy showing a patchy process with honeycomb ... New idiopathic pulmonary fibrosis guidelines: some unresolved questions. [Am J Respir Crit Care Med. 2012] ... Review: Current drug treatments do not reduce mortality in idiopathic pulmonary fibrosis. [Ann Intern Med. 2011] ... An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. ...
What is the role of open lung biopsy in the workup of fungal pneumonia?
... performing an open lung biopsy is the only way to prove invasive disease for Aspergillus or Candida organisms. However, this ... Idiopathic Pulmonary Fibrosis: Killer Without a Cause Most Popular Articles. According to Pulmonologists ... Pulmonary Physiology Laboratory, Director of Research in Pulmonary Medicine, Department of Medicine, Section of Pulmonary ... Jesus Lanza, MD Fellow in Pulmonary and Critical Care Medicine, Department of Medicine, Section of Pulmonary Medicine, Lenox ...
Which biopsy findings are characteristic of fungal pneumonia?
Biopsy specimens show the following: Caseating or necrotizing granulomas with intracellular organisms inside macrophages (eg, H ... Idiopathic Pulmonary Fibrosis: Killer Without a Cause Most Popular Articles. According to Pulmonologists ... Pulmonary Physiology Laboratory, Director of Research in Pulmonary Medicine, Department of Medicine, Section of Pulmonary ... Jesus Lanza, MD Fellow in Pulmonary and Critical Care Medicine, Department of Medicine, Section of Pulmonary Medicine, Lenox ...
Idiopathic Pulmonary Fibrosis (IPF): Diagnosis
Correlating Outcomes With Biochemical Markers to Estimate Time-progression in Idiopathic Pulmonary Fibrosis (IPF)
The disease course of idiopathic pulmonary fibrosis (IPF) is variable. During the course of the disease some... ... lung biopsy.. Description. The objectives of this study are as follows:. Specific Aim 1: Assemble a network of clinical centers ... Pirfenidone for the Treatment of Patients With Pulmonary Fibrosis/Idiopathic Pulmonary Fibrosis (PF/IPF) ... in a limited number of patients with pulmonary fibrosis/idiopathic pulmonary fibrosis (PF/IPF) ...
Rapidly Progressive Pulmonary Apical Fibrosis and Parenchymal Destruction in a Patient with Ankylosing Spondylitis
Biopsy revealed no finding of malignancy, granulomatous inflammation, or vasculitis. The results of cultures were negative. So ... Herein, we are presenting a patient with AS who rapidly developed pulmonary apical fibrosis in a 3-year period despite ... However, thoracic computed tomography of the patient performed 3 years ago did not reveal pulmonary apical fibrosis and ... the patient was diagnosed as pulmonary involvement of AS, which developed in a 3-year period. This case has shown that extra- ...
Could prominent airway-centered fibroblast foci in lung biopsies predict underlying chronic microaspiration in idiopathic...
Pirfenidone in idiopathic pulmonary fibrosis | European Respiratory Society
Surgical lung biopsy. 26 (24.1). 16 (29.1). 28 (26.9). 0.78. VC mL. 2400.8±638.4. 2437.8±684.8. 2472.3±698.9. 0.74. ... Pirfenidone in idiopathic pulmonary fibrosis. H. Taniguchi, M. Ebina, Y. Kondoh, T. Ogura, A. Azuma, M. Suga, Y. Taguchi, H. ... Pirfenidone in idiopathic pulmonary fibrosis. H. Taniguchi, M. Ebina, Y. Kondoh, T. Ogura, A. Azuma, M. Suga, Y. Taguchi, H. ... Pirfenidone in idiopathic pulmonary fibrosis. H. Taniguchi, M. Ebina, Y. Kondoh, T. Ogura, A. Azuma, M. Suga, Y. Taguchi, H. ...
Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis? - PubMed - NCBI
All diagnoses were confirmed or supported by open lung biopsy. Three of the patients with idiopathic pulmonary fibrosis had ... three had a definite diagnosis of idiopathic pulmonary fibrosis. The patients with idiopathic pulmonary fibrosis and usual ... Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis?. Lynch DA1, Newell JD, Logan PM, King TE Jr ... Our results show that CT can be used to distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis in most but ...
Positive Antinuclear Factor in Patients with Unexplained Pulmonary Fibrosis | Annals of Internal Medicine | American College of...
Four lung biopsies were available. Three showed histological evidence of interstitial pulmonary fibrosis. Immunofluorescent ... A Multidimensional Index and Staging System for Idiopathic Pulmonary Fibrosis Annals of Internal Medicine; 156 (10): 684-691 ... study of one of the biopsy sections with pulmonary fibrosis from a patient with only IgM serum antinuclear factor showed IgM in ... Positive Antinuclear Factor in Patients with Unexplained Pulmonary Fibrosis HIROSHI NAGAYA, M.D.; C. EDWARD BUCKLEY III, M.D.; ...
Pulm Flashcards by Kush Sharma | Brainscape
pulm fibrosis NOTHING, but if biopsy shows white cell or inflammatory infiltrate, prednisone can be used; can treat berylliosis ... Pressure measured during an inspiratory hold maneuver when pulmonary airflow and thus resistive pressures are both 0 ... Most accurate: Lung biopsy; high res. CT scan less accurate, but more accurate than CXR ...
Vascular dysfunction by myofibroblast activation in patients with idiopathic pulmonary fibrosis and prognostic significance
Open lung biopsies. Pulmonary specimens were obtained by surgical lung biopsy from 27 patients with IPF/UIP (14 males and 13 ... using 27 surgical lung biopsies from patients with idiopathic pulmonary fibrosis (IPF). Telomerase+, myofibroblasts α-SMA+, ... Phan SH, Varani J, Smith D. Rat lung fibroblast collagen metabolism in bleomycin-induced pulmonary fibrosis. J Clin Invest 1985 ... Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax 2006; 61: 980-985. [ Links ]. ...
Pulmonary fibrosis - Symptoms and causes - Mayo Clinic
Pulmonary fibrosis - Learn about the symptoms, causes and treatment of this serious lung disease that occurs when lung tissue ... Role of lung biopsy in the diagnosis of interstitial lung disease. http://www.uptodate.com/home. Accessed June 9, 2016. ... Pulmonary fibrosis. Pulmonary fibrosis. Pulmonary fibrosis scars and thickens the tissue around and between the air sacs ( ... As pulmonary fibrosis worsens, you become progressively more short of breath.. The scarring associated with pulmonary fibrosis ...
Dental Personnel Treated for Idiopathic Pulmonary Fibrosis at a Tertiary Care Center - Virginia, 2000-2015 | MMWR
Nine cases of idiopathic pulmonary fibrosis were identified among dental personnel treated at a tertiary care center in ... Nine cases of idiopathic pulmonary fibrosis were identified among dental personnel treated at a tertiary care center in ... no biopsy specimens were available for examination to assess histological commonalities among the patients. ... ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary ...
Pulmonary Fibrosis | Annals of Internal Medicine | American College of Physicians
In these patients, it has been a variance in the clinical and laboratory features from those found on initial lung biopsy that ... To the editor: We wish to make a few comments in reference to the NIH conference on idiopathic pulmonary fibrosis (1). ... Pulmonary Fibrosis RICHARD A. DEREMEE, M.D.; HOWARD A. ANDERSEN, M.D. ... Idiopathic Pulmonary Fibrosis: Clinical, Histologic, Radiographic, Physiologic, Scintigraphic, Cytologic, and Biochemical ...
Interstitial (Nonidiopathic) Pulmonary Fibrosis Medication: Corticosteroids, Immunosuppressants, Anti-inflammatories, Pulmonary...
Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2001 Jul 15. 164(2):193 ... encoded search term (Interstitial (Nonidiopathic) Pulmonary Fibrosis) and Interstitial (Nonidiopathic) Pulmonary Fibrosis What ... et al for the Idiopathic Pulmonary Fibrosis Study Group. High-resolution computed tomography in idiopathic pulmonary fibrosis: ... Interstitial (Nonidiopathic) Pulmonary Fibrosis Medication. Updated: Oct 16, 2018 * Author: Eleanor M Summerhill, MD, FACP, ...
Open lung biopsy | definition of open lung biopsy by Medical dictionary
What is open lung biopsy? Meaning of open lung biopsy medical term. What does open lung biopsy mean? ... Looking for online definition of open lung biopsy in the Medical Dictionary? open lung biopsy explanation free. ... Facts about idiopathic pulmonary fibrosis. Diagnosis of SH generally requires an open lung biopsy.. Sclerosing hemangioma ... Biopsy, Lung. Synonym/acronym: Transbronchial lung biopsy, open lung biopsy. Common use. To assist in diagnosing lung cancer ...
JCI - WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic...
Human tissues. Lung tissue biopsy samples were obtained from 10 patients with IPF (UIP pattern; mean age, 51 ± 11 years; 4 ... WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary ... Fibroblast phenotypes in pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 29:S87-S92. View this article via: PubMed Google ... Idiopathic pulmonary fibrosis. N. Engl. J. Med. 345:517-525. View this article via: CrossRef PubMed Google Scholar ...
Pulmonary Fibrosis - What You Need to Know
Care guide for Pulmonary Fibrosis. Includes: possible causes, signs and symptoms, standard treatment options and means of care ... A lung biopsy may be needed to confirm that you have pulmonary fibrosis. A sample of your lung tissue is sent to a lab for ... How is pulmonary fibrosis treated?. There is no cure for pulmonary fibrosis. The goal of treatment is to slow the progress of ... The cause of pulmonary fibrosis may not be known. The following may increase your risk:. *Family history of pulmonary fibrosis ...
935. Malathion (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental)
Mild interstitial pulmonary fibrosis was observed in a lung biopsy sample. Matsushita et al. (1985) reported allergic contact ... Dinsdale, D. (1992) Pulmonary toxicity of anticholinesterases. In: Ballantyne, B. & Marrs, T.C., eds, Clinical and Experimental ... A typical cholinergic crisis was followed by cardiac, pulmonary, neurological, and renal manifestations, and the patient was ... 1985) and Dinsdale (1992)]. These compounds are notable for their pulmonary toxicity. Furthermore, isomalathion has a greater ...
Overlap connective tissue disease, pulmonary fibrosis, and extensive subcutaneous calcification | Annals of the Rheumatic...
An HRCT scan of the lung showed pulmonary fibrosis. Transbronchial biopsy revealed pulmonary fibrosis with a lymphocytic ... The pattern of pulmonary fibrosis and extensive subcutaneous buttock calcification in both our cases may be seen in overlap ... 5 We describe two patients who had pulmonary fibrosis and extensive subcutaneous calcification of the buttocks in the same ... Skin biopsy showed degeneration of the basal cell layer with vacuolar changes and a mononuclear cell infiltrate in the upper ...
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- Advances in HRCT scanning and interpretation have facilitated and improved accuracy for use in diagnosing idiopathic pulmonary fibrosis (IPF), eliminating the need for a surgical biopsy in many patients. (springeropen.com)
- Surgical lung biopsy is difficult in many cases, and consequently, efforts are being made to limit the need for this measure to reach a diagnosis (e.g., by considering clinical and radiographic features as well as PFT) [ 5 ]. (springeropen.com)
- The extent of honeycombing and reticulation has been used as a predictor of mortality in patients with idiopathic pulmonary fibrosis (IPF) [ 9 ]. (springeropen.com)
- HRCT may be used to identify sites for bronchoalveolar lavage and lung biopsy, guide treatment strategies, and predict treatment outcomes [ 6 ]. (springeropen.com)
- Honeycombing is a feature of established fibrosis and is considered as an important criterion when diagnosing UIP and IPF, although recent evidence suggests that honeycombing may not be required for an HRCT-based diagnosis of IPF in selected patients. (springeropen.com)
Diagnosis of idiopathic pulmonar8
- The diagnosis of idiopathic pulmonary fibrosis (IPF) typically involves questioning about medical history and examinations to classify the condition and eliminate other possible conditions. (news-medical.net)
- Current guidelines for the diagnosis of idiopathic pulmonary fibrosis (IPF) provide specific criteria for diagnosis in the setting of multidisciplinary discussion (MDD). (bioportfolio.com)
- In these patients, the CT diagnosis was correct in 35 cases (90%): 23 of 26 patients with a CT diagnosis of idiopathic pulmonary fibrosis and 12 of 13 patients with a CT diagnosis of hypersensitivity pneumonitis. (nih.gov)
- three had a definite diagnosis of idiopathic pulmonary fibrosis. (nih.gov)
- In April 2016, a Virginia dentist who had recently received a diagnosis of idiopathic pulmonary fibrosis (IPF) and was undergoing treatment at a specialty clinic at a Virginia tertiary care center contacted CDC to report concerns that IPF had been diagnosed in multiple Virginia dentists who had sought treatment at the same specialty clinic. (cdc.gov)
- Two guidance documents for the diagnosis of idiopathic pulmonary fibrosis (IPF) have been recently published by international experts representing major respiratory and radiological societies [ 1 , 2 ]. (ersjournals.com)
- In 1969 Liebow and Carrington 4 described a group of idiopathic interstitial pneumonias that included usual interstitial pneumonia (UIP) which is associated with the clinical diagnosis of idiopathic pulmonary fibrosis. (jabfm.org)
- The diagnosis of idiopathic pulmonary fibrosis: current and future approaches. (mayoclinic.org)
- A stethoscope can be used to listen to the sound of breathing in the lungs, as a crackling sound can be suggestive of fibrosis. (news-medical.net)
- Pulmonary function tests are designed to assess the function of the lungs, including the passage of air in and out, the total capacity and the ability to transfer oxygen into the blood. (news-medical.net)
- This is usually carried out under general anesthetic and involves a number of small incisions and the insertion of an endoscope into the lungs, which can be used to take the biopsy. (news-medical.net)
- Idiopathic pulmonary fibrosis (IPF) is scarring or thickening of the lungs without a known cause. (medlineplus.gov)
- Pulmonary fibrosis is a chronic, progressive fibrosing interstitial pneumonia of unknown cause and results in the lungs becoming thick and stiff, or scarred, over time. (patientslikeme.com)
- Telomerase activity in minimal fibrosis areas was directly associated with diffusing capacity of the lung for oxygen/alveolar volume and ET-1 expression and indirectly associated with diffusing capacity of the lungs for carbon monoxide and severe fibrosis in vascular areas. (scielo.br)
- Pulmonary fibrosis scars and thickens the tissue around and between the air sacs (alveoli) in your lungs, as shown on the right. (mayoclinic.org)
- Pulmonary fibrosis scars and thickens the tissue around and between the air sacs (alveoli) in your lungs. (mayoclinic.org)
- Biopsies from fibrotic human lungs demonstrate epithelial cells with mesenchymal features, suggesting EMT. (pnas.org)
- Pulmonary function tests are a group of tests that measure breathing and how well the lungs are functioning. (limamemorial.org)
- Interstitial fibrosis' is the term used to refer to the scarring of the lungs that can result from prolonged interstitial inflammation. (medicinenet.com)
- Researchers performed extensive lab and genetic analyses on biopsied human lungs donated by IPF patients and mouse models of IPF to find out that when FOXF1 is repressed its sister gene FOXM1 increases and fuels the disease. (cincinnatichildrens.org)
- Idiopathic pulmonary fibrosis (ipf) is a progressive, unrelenting scarring of the lungs. (healthtap.com)
- Idiopathic pulmonary fibrosis means that there is scarring of the lungs and the underlying reason for the scarring is not known. (healthtap.com)
- Bronchoscopy with biopsy (viewing the lungs by inserting a flexible tube with a camera through the mouth and taking a sample of tissue for analysis) may be performed to confirm the diagnosis. (healthcentral.com)
- The outlook for recovery is generally poor for occupational dust diseases and idiopathic (no-known cause) interstitial pulmonary fibrosis in which the lungs progressively stiffen. (healthcentral.com)
- Pulmonary fibrosis is a condition in which the tissue deep in your lungs becomes scarred over time. (medlineplus.gov)
- Pulmonary fibrosis is a disease that affects the lungs. (checkbiotech.org)
- Pulmonary fibrosis (literally "scarring of the lungs") is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems. (wikipedia.org)
- Idiopathic pulmonary fibrosis (IPF) is a chronic disease of the lungs. (denverhealth.org)
- Idiopathic pulmonary fibrosis (IPF) is a serious condition that causes the tiny air sacs in the lungs (known as the alveoli) and the surrounding tissue to become damaged. (medic8.com)
- Pulmonary fibrosis is an interstitial lung disease, part of a group of conditions that cause inflammation and scarring around the tiny alveoli (air sacs) in the lungs. (nm.org)
- Idiopathic pulmonary fibrosis (IPF) is a progressive disease isolated to the lungs. (clevelandclinic.org)
- Interstitial lung diseases are named after the tissue between the air sacs of the lungs called the interstitium -- the tissue affected by fibrosis (scarring). (mydochub.com)
- Idiopathic pulmonary fibrosis (IPF) is a rare form of fibrotic lung disease with no known aetiology that progresses over the course of several years and is characterised by scar tissue formation within the lungs, dyspnoea, and a significantly shortened lifespan after diagnosis. (bmj.com)
- Because it can be difficult to obtain lung biopsy samples for some types of interstitial lung disease, the Simmons Center investigators collaborated with researchers in Mexico to obtain samples for another type of pulmonary fibrosis known as hypersensitivity pneumonitis - a pneumonia-like inflammation of the lungs caused by the body's immune reaction to small air-borne particles that is more prevalent in countries such as Mexico where pet birds are common. (biologynews.net)
- This can be obtained by bronchoscopy (a procedure of inserting a small flexible tube into your mouth or nose down into your lungs to obtain a small sample of lung tissue), or by a surgical lung biopsy (a surgery involving small incisions in the side of your chest to remove small pieces of lung tissue). (piedmont.org)
- Asbestos is is pulmonary fibrosis caused by accumulation of airborne asbestos in the lungs. (cdc.gov)
- 1992) Absolute quantification of gallium-67 citrate accumulation in the lungs and its importance for the evaluation of disease activity in pulmonary sarcoidosis. (springer.com)
- Pulmonary fibrosis is an interstitial lung disease of the lower respiratory tract involving damage to the alveoli (air sacs) of the lungs, leading to reduced transfer of oxygen into the bloodstream. (earthclinic.com)
- At other times this fibrosis of the lungs (fiber build-up) is of unknown cause and therefore termed idiopathic pulmonary fibrosis. (earthclinic.com)
Surgical lung biopsy8
- Surgical lung biopsy specimens demonstrating UIP pattern. (nih.gov)
- Diagnosis requires HRCT and in some cases surgical lung biopsy. (merckmanuals.com)
- A surgical lung biopsy is indicated for patients without an HRCT appearance of UIP to differentiate between histological UIP and NSIP. (bmj.com)
- Several recent studies have shown that examination of surgical lung biopsy specimens allows identification of histopathological subsets of idiopathic interstitial pneumonia (IIP) with different prognoses. (bmj.com)
- There are several methods for performing a surgical lung biopsy so your doctor will recommend which procedure is best for you. (healthline.com)
- Surgical lung biopsy may be necessary for a definitive diagnosis. (ovid.com)
- Diagnostic yield and postoperative mortality associated with surgical lung biopsy for evaluation of interstitial lung diseases: A systematic review and meta-analysis. (mayoclinic.org)
- Surgical lung biopsy: Surgery used in some cases to diagnose the type of lung disease. (massgeneral.org)
- In general, the presence of a honeycomb effect in the lung tissue often reflects scarring in the area and is indicative of fibrosis. (news-medical.net)
- Video-assisted thoracoscopic surgery (VATS) is a technique used to obtain a biopsy of the lung tissue, which may be required to eliminate other conditions in the diagnostic process. (news-medical.net)
- 3. Scarring (or fibrosis) begins in the interstitium (or tissue between the air sacs), and the lung becomes stiff. (digitalnaturopath.com)
- When scarring of the lung tissue takes place, the condition is called pulmonary fibrosis . (digitalnaturopath.com)
- Fibrosis, or scarring of the lung tissue, results in permanent loss of that tissue's ability to transport oxygen. (digitalnaturopath.com)
- A ) Scanning power microscopy showing a patchy process with honeycomb spaces ( thick arrow ), some preserved lung tissue regions ( thin arrow ), and fibrosis extending into the lung from the subpleural regions. (nih.gov)
- B ) Adjacent to the regions of more chronic fibrosis ( thick arrow ) is a fibroblast focus ( asterisk ), recognized by its convex shape and composition of edematous fibroblastic tissue, suggestive of recent lung injury. (nih.gov)
- In previous studies, we found a direct relationship between progressive vascular occlusion by collagen/elastic fiber deposition and tissue remodeling in surgical lung biopsies from patients with IPF (4,5). (scielo.br)
- Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. (mayoclinic.org)
- Pulmonology A procedure in which the chest cavity is opened to allow visually directed biopsy of lung tissue Indications Diagnose bronchiolitis, chronic interstitial lung disease, lung CA, eosinophilic granuloma, honeycomb lung, lymphoma, pulmonary HTN, sarcoidosis Pros Greater diagnostic yield than transbronchial Bx Cons ↑ complications Complications Pneumothorax, hemorrhage, air embolism. (thefreedictionary.com)
- A biopsy of the lung is performed to obtain lung tissue for examination of pathological features. (thefreedictionary.com)
- In an open lung biopsy, the chest is opened and a small thoracic incision is made to remove tissue from the chest wall. (thefreedictionary.com)
- 5 We describe two patients who had pulmonary fibrosis and extensive subcutaneous calcification of the buttocks in the same sequence as part of an overlap connective tissue disease. (bmj.com)
- The key histologic findings are subpleural fibrosis with sites of fibroblast proliferation (fibroblast foci) and dense scarring, alternating with areas of normal lung tissue (heterogeneity). (merckmanuals.com)
- The diagnosis of interstitial lung disease typically involves imaging tests, measurement of blood oxygen levels, and sometimes, biopsies or tissue sampling. (medicinenet.com)
- In this microscopic photo of tissue from a mouse lung with idiopathic pulmonary fibrosis (IPF), extensive fibrosis and collagen deposits (shown in red) have extensively infiltrated the tissue. (cincinnatichildrens.org)
- Causes of pulmonary fibrosis include environmental pollutants, some medicines, some connective tissue diseases, and interstitial lung disease. (medlineplus.gov)
- In cases when the diagnosis is unclear, a tissue sample, or biopsy, may be necessary. (healthline.com)
- Scar formation, the accumulation of excess fibrous connective tissue (the process called fibrosis), leads to thickening of the walls, and causes reduced oxygen supply in the blood. (wikipedia.org)
- Infections Certain medications, e.g. amiodarone, bleomycin (pingyangmycin), busulfan, methotrexate, apomorphine, and nitrofurantoin Radiation therapy to the chest Pulmonary fibrosis involves gradual exchange of normal lung parenchyma with fibrotic tissue. (wikipedia.org)
- The replacement of normal lung with scar tissue causes irreversible decrease in oxygen diffusion capacity, and the resulting stiffness or decreased compliance makes pulmonary fibrosis a restrictive lung disease. (wikipedia.org)
- A videoscopic assisted thoracoscopic wedge biopsy (VATS) under general anesthesia may be necessary to obtain enough tissue to make an accurate diagnosis. (wikipedia.org)
- The removed tissue is examined histopathologically by microscopy to confirm the presence and pattern of fibrosis as well as presence of other features that may indicate a specific cause e.g. specific types of mineral dust or possible response to therapy e.g. a pattern of so-called non-specific interstitial fibrosis. (wikipedia.org)
- The scarring related to pulmonary fibrosis causes lung tissue to get thick and stiff, making it hard for the body to take in oxygen. (nm.org)
- ILDs include forms of pulmonary fibrosis and interstitial pneumonia, as well as ILDs associated with connective tissue diseases, tobacco use, and exposure to environmental and occupational toxins. (clevelandclinic.org)
- characteristic histologic changes of lung tissue obtained by bronchoscopic or open lung biopsy. (medicalcriteria.com)
- Moreover, in a related study, the investigators identified a protein found in excess amounts in the lung tissue of patients with idiopathic pulmonary fibrosis, which may be a more appropriate target for therapy. (biologynews.net)
- Idiopathic pulmonary fibrosis is characterized by the increased expression of genes involved in the re-growth of lung tissue. (biologynews.net)
- Pulmonary Fibrosis is a form of interstitial lung disease (ILD) that causes inflammation and eventual scarring (fibrosis) in place of normal healthy lung tissue. (piedmont.org)
- A lung biopsy process extracts a small piece of lung tissue which can be examined under a microscope. (altiusdirectory.com)
- In a lung biopsy procedure, the health professional will take out a piece of lung tissue to examine it below the microscope. (medicalhealthtests.com)
- Bronchoscope lung biopsy is done with a bronchoscope that is put through the nose or mouth, and into the airways, and then used to take out a sample piece of tissue. (medicalhealthtests.com)
- This method is chosen when the other two methods of lung biopsy have not been successful, or if a large piece of tissue is needed. (medicalhealthtests.com)
- Fibrosis, the progressive accumulation of connective tissue that occurs in response to injury, causes irreparable organ damage and may result in organ failure. (jci.org)
- Here we review currently available molecular imaging probes for detecting fibrosis and fibrogenesis, the active formation of new fibrous tissue, and their application to models of fibrosis across organ systems and fibrotic processes. (jci.org)
- Liquid biopsy may be a suitable alternative to the standard gold tissue biopsy to detect clinically relevant mutations and help guide their course of treatment, suggests a new study. (medindia.net)
- Liquid biopsies captured clinically relevant mutations not found in tissue biopsies as patients' disease progressed. (medindia.net)
- In patients with advanced non-small cell lung cancer (NSCLC) treated at Penn's ACC, mutations detected from liquid biopsies (cell-free circulating tumor DNA (ctDNA) captured from blood) closely paralleled the mutations from tissue biopsies identified in next generation sequencing tests: EGRF, TP53, and ALK, to name a few. (medindia.net)
- These data add to the growing evidence supporting the use of liquid biopsies, particularly when tissue samples are nonexistent or hard to obtain, as is often the case with lung cancer and other cancers that have metastasized throughout the body. (medindia.net)
- About half of the 102 patients in this study did not have sequenceable biopsy tissue, so researchers relied on blood tests to detect mutations. (medindia.net)
- Keeping up with such an evolution is not as feasible with traditional tissue biopsies, the authors said, but much more plausible with serial blood samples. (medindia.net)
- The tissue biopsy sequencing result has been considered the gold standard against which one compares the ctDNA result. (medindia.net)
- Serial liquid biopsies were also performed on six patients as part of disease surveillance, and in all six cases, the results helped guide clinical decision making, either by identifying a driver or resistance mutation amenable to targeted therapy, or by confirming that chemotherapy was likely the best course of action when a tissue sample was not possible. (medindia.net)
- A number of habits, respiratory toxins, and health issues can cause scarring of your lung tissue, which is the principle symptom of pulmonary fibrosis. (earthclinic.com)
Type of pulmonary fibrosis3
- People with the severe type of pulmonary fibrosis do become ill rapidly, as compared to people with moderate severity. (checkbiotech.org)
- Misdiagnosis is common because, while overall pulmonary fibrosis is not rare, each individual type of pulmonary fibrosis is uncommon and the evaluation of patients with these diseases is complex and requires a multidisciplinary approach. (wikipedia.org)
- It is classified as a type of pulmonary fibrosis and not a form of cancer. (pleuralmesothelioma.com)
Open lung biopsy6
- What is the role of open lung biopsy in the workup of fungal pneumonia? (medscape.com)
- Occasionally, performing an open lung biopsy is the only way to prove invasive disease for Aspergillus or Candida organisms. (medscape.com)
- All diagnoses were confirmed or supported by open lung biopsy. (nih.gov)
- The specimen can be obtained transbronchially or by open lung biopsy. (thefreedictionary.com)
- To define the diagnosis of lung lesion, open lung biopsy was promptly performed. (lww.com)
- At 2 months after open lung biopsy, follow-up chest images showed combined pulmonary fibrosis and emphysema [ Figure 1f ]. (lww.com)
- Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis? (nih.gov)
- The clinical management of patients with idiopathic pulmonary fibrosis differs markedly from that of patients with hypersensitivity pneumonitis. (nih.gov)
- Thirty-six patients with idiopathic pulmonary fibrosis and 27 patients with hypersensitivity pneumonitis were studied. (nih.gov)
- The patients with idiopathic pulmonary fibrosis and usual interstitial pneumonia were more likely to have honeycombing and peripheral or lower lung zone predominance of disease, and less likely to have micronodules, than were patients with chronic hypersensitivity pneumonitis. (nih.gov)
- The patients with idiopathic pulmonary fibrosis and desquamative interstitial pneumonia had widespread ground-glass opacity indistinguishable from some cases of acute or subacute hypersensitivity pneumonitis. (nih.gov)
- Our results show that CT can be used to distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis in most but not all cases. (nih.gov)
- Perhaps the earliest known cause of fibrosis was inhaled antigen-mediated hypersensitivity pneumonitis. (jabfm.org)
- Chronic hypersensitivity pneumonitis (CHP) and fibrotic sarcoidosis (S4), which are not listed as idiopathic fibrosis, further complicate diagnosis because of their relative frequency and similar presenting features. (jabfm.org)
- Our results show that interstitial pulmonary fibrosis and hypersensitivity pneumonitis, which clinically often look quite similar, are really two vastly different conditions," said Dr. Kaminski. (biologynews.net)
- Two of the eight cases exhibited interstitial pulmonary fibrosis-like gene expression patterns, one closely resembled the gene expression pattern of hypersensitivity pneumonitis, while the other five expression patterns resembled neither. (biologynews.net)
Shortness of bre6
- A year later she developed shortness of breath, and a high resolution computed tomography (HRCT) scan of the lung disclosed basal fibrosis with areas of ground glass shadowing. (bmj.com)
- At the end of life pulmonary fibrosis patients mainly develope severe shortness of breath/dyspnea. (healthtap.com)
- Some of the signs and symptoms of pulmonary fibrosis include shortness of breath, chronic dry cough, chest discomfort, loss of weight, loss of appetite, and so on. (checkbiotech.org)
- Patients affected by pulmonary fibrosis would likely have a history of a progressive shortness of breath with exertion. (checkbiotech.org)
- Symptoms of pulmonary fibrosis are mainly: Shortness of breath, particularly with exertion Chronic dry, hacking coughing Fatigue and weakness Chest discomfort including chest pain Loss of appetite and rapid weight loss Pulmonary fibrosis is suggested by a history of progressive shortness of breath (dyspnea) with exertion. (wikipedia.org)
- A pulmonary fibrosis diagnosis likely comes after you have experienced symptoms including shortness of breath, weight loss, exhaustion, and possibly sore muscles. (earthclinic.com)
- Biopsy revealed no finding of malignancy, granulomatous inflammation, or vasculitis. (hindawi.com)
- The pathologic hallmarks of IPF include heterogeneous injury/fibrosis, scattered foci of fibroblast accumulation beneath flattened alveolar epithelial cells (AECs), and scant inflammation ( 1 ). (pnas.org)
- The response to corticosteroids is better in patients with more inflammation and less fibrosis noted on lung biopsy. (healthcentral.com)
- Pulmonary fibrosis is perpetuated by aberrant wound healing, rather than chronic inflammation. (wikipedia.org)
- Pulmonary Fibrosis caused by chronic inhalation of agents that injure the lung, by causing inflammation and eventually leading to scarring (fibrosis) of the lung. (mountsinai.org)
- and varying degrees of inflammation, fibrosis, or both on lung biopsy. (bmj.com)
- In an article in the Jan. 15 issue of the American Journal of Respiratory Critical Care Medicine, University of Pittsburgh researchers report that a serious, life-threatening form of pulmonary fibrosis, called idiopathic pulmonary fibrosis, lacks all the hallmarks of inflammation and is probably unnecessarily treated with anti-inflammatory drugs. (biologynews.net)
- The latter is characterized by inflammation and fibrosis that occurs suddenly and progresses rapidly over a relatively short period of time. (biologynews.net)
- In contrast, there was almost no genetic evidence of inflammation in the idiopathic pulmonary fibrosis samples. (biologynews.net)
- Although pleural biopsy showed chronic inflammation, the effusion was exudates dominantly with lymphocyte cells and adenosine deaminase was 136.2 IU/L, highly suggesting TB pleurisy. (lww.com)
- Biopsy at right lower lobe revealed chronic interstitial inflammation with fibrosis [ Figure 1e ]. (lww.com)
- Interstitial pneumonia (IP) refers to involvement of the lung parenchyma by varying degrees of inflammation and fibrosis, in contrast to airspace disease typically seen in bacterial pneumonia. (intechopen.com)
- Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmonary Disease? (mdpi.com)
- Specific Aim 2: Correlate and integrate biologically plausible biomarkers of disease activity obtained from multiple compartments (SLB, BAL, TBB, blood) from the same subject with longitudinal measures of disease progression (change in forced vital capacity, change in diffusion capacity for carbon monoxide, acute exacerbation of pulmonary fibrosis, and death). (bioportfolio.com)
- Physicians usually prescribe antibiotics and corticosteroids for the treatment of the acute exacerbation of pulmonary fibrosis. (checkbiotech.org)
- A physical examination, chest X-ray, pulmonary function tests, bronchoscopy, bronchoalveolar lavage, lung biopsy and blood tests may be needed. (digitalnaturopath.com)
- To investigate the direct relationship between fibrosis and cancer development, the real concordance rate of the two lesions in the chest computed tomography (CT) was analysed and compared to the histological types of lung cancer. (ersjournals.com)
- This study was performed to investigate whether the fibrosis is directly related to cancer development by the analysis of the real concordance rate of the lesions on the chest CT, and to compare the histological types of lung cancer in 63 patients with lung cancer and IPF. (ersjournals.com)
- A high resolution CT scan of the chest showed pulmonary fibrosis with no hilar adenopathy. (ispub.com)
- This kind of biopsy involves placement of several tubes through the chest wall, one of which is used to cut off a piece of lung to send for evaluation. (wikipedia.org)
- Although UIP can be detected by high-resolution computed tomography of the chest, the results are frequently inconclusive, and pathology from transbronchial biopsy (TBB) has poor sensitivity. (ovid.com)
- The Massachusetts General Hospital Interstitial Lung Disease Program multidisciplinary team includes lung specialists, chest radiologists, pulmonary pathologists, thoracic surgeons and research scientists. (massgeneral.org)
- Lung biopsy helps to examine any abnormalities witnessed on other tests, like chest X-ray or a CT scan. (altiusdirectory.com)
- If there are any abnormalities in some of the other tests like CT scan or chest X-ray, then a lung biopsy might be essential. (medicalhealthtests.com)
- Your doctor will start with standard lung function tests but will have to progress at least to chest imaging and perhaps to a lung biopsy for conclusive diagnosis of pulmonary fibrosis. (earthclinic.com)
- This study identifies a novel anti-fibrotic drug target that inhibits pulmonary fibrosis in our preclinical models," said lead investigator Tanya Kalin, MD, PhD , Division of Pulmonary Biology . (cincinnatichildrens.org)
- Co-trimoxazole treatment has no effect on pulmonary function or 6 min walk distance in patients with fibrotic idiopathic interstitial pneumonia (the majority of whom had idiopathic pulmonary fibrosis) but, given adequate adherence to the medication, may lead to a significant reduction in all-cause mortality associated with reduction in frequency of respiratory tract infections and improved overall health-related quality of life. (bmj.com)
- Idiopathic pulmonary fibrosis (IPF) is the commonest form of fibrotic idiopathic interstitial pneumonia (IIP). (bmj.com)
- Usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic pulmonary fibrotic diseases and has the worst prognosis with a mean life expectancy of 3.8 years. (jabfm.org)
- Idiopathic pulmonary fibrosis (IPF) is a rare fibrotic interstitial lung disease with a relentlessly progressive course and fatal outcome. (biomedcentral.com)
- Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis. (mdedge.com)
- Thoracic high-resolution computed tomography showed a consolidation accompanied with traction bronchiectases compatible with chronic fibrosis in the upper lobe of the right lung. (hindawi.com)
- However, thoracic computed tomography of the patient performed 3 years ago did not reveal pulmonary apical fibrosis and parenchymal destruction. (hindawi.com)
- Lung biopsies are used to differentiate between infection and other sources of disease indicated by initial radiology studies, computed tomography scans, or sputum analysis. (thefreedictionary.com)
- and 3) pathological confirmation by surgical (open or thoracoscopic) lung biopsy, or high-resolution computed tomography (HRCT) showing typical patterns of IPF such as subpleural reticular densities or honeycombing lesions predominantly in lower lobes 15 - 18 . (ersjournals.com)
- The mainstream of IPF diagnosis is thoracic radiology, in particular high-resolution computed tomography, combined with lung biopsy in some cases. (biomedcentral.com)
- High-resolution computed tomography is particularly useful for diagnosing interstitial lung disease, idiopathic pulmonary fibrosis, bronchiectasis, or pulmonary embolism. (aafp.org)
Cure for idiopathic pulmonar2
- There is currently no cure for idiopathic pulmonary fibrosis, however, treatments are available to suppress and ease symptoms. (medic8.com)
- The mission of the Pulmonary Fibrosis Foundation (PFF) is to help find a cure for idiopathic pulmonary fibrosis (IPF), advocate for the pulmonary fibrosis community, promote disease awareness, and provide a compassionate environment for patients and their families. (greatnonprofits.org)
Symptoms of idiopathic pulmonar1
Treatment of idiopathic pulmonar3
- Supportive treatment options include oxygen and pulmonary rehabilitation. (cdc.gov)
- Go to pulmonary rehabilitation (PR). (drugs.com)
- Important supportive measures include smoking cessation, pulmonary rehabilitation, and supplemental oxygen when appropriate. (bmj.com)
- This can often be managed with use of supplemental oxygen, participation in a pulmonary rehabilitation program, preventive care, and treating other health conditions appropriately. (piedmont.org)
- Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies, or post-mortem examination from individuals with this disorder may contribute to our understanding of the pathogenic mechanisms of pulmonary fibrosis. (clinicaltrials.gov)
- The purpose of this protocol is to procure and analyze blood, genomic DNA, and specimens by bronchoscopy, lung biopsy, lung transplantation, extra-pulmonary biopsies, or post-mortem examination from subjects with pulmonary fibrosis. (clinicaltrials.gov)
- Prompt treatment is necessary for complicating pulmonary disease such as cor pulmonale (oxygen, diuretics), pulmonary embolism (anticoagulants), and infection (antibiotics). (medscape.com)
- Pulmonary function tests (PFTs) will show how much oxygen your body is getting. (drugs.com)
- Relief of symptoms can be achieved through pulmonary treatments and oxygen therapy. (clevelandclinic.org)
- Fibrosis results in permanent loss of that tissue's ability to breathe and carry oxygen. (mydochub.com)
Causes of pulmonary3
- Several causes of pulmonary fibrosis are known. (digitalnaturopath.com)
- What Are The Causes Of Pulmonary Fibrosis? (checkbiotech.org)
- Some known causes of pulmonary fibrosis include occupational and environmental exposure to asbestos, metal dust, farming chemicals and mold, an inflammatory disease called sarcoidosis, radiation, drug reactions, autoimmune disorders and possibly a genetic predisposition, according to the American Lung Association. (innovations-report.com)
Chronic fibrosing in2
- Idiopathic pulmonary fibrosis (IPF) is a devastating chronic fibrosing interstitial pneumonia of unknown etiology that typically increases in prevalence with advanced age, characterized by excessive collagen deposition and irreversible remodeling of the lung parenchyma (1,2). (scielo.br)
- Idiopathic pulmonary fibrosis is defined as a chronic fibrosing interstitial pneumonia limited to the lung, of unknown cause, with poor prognosis and few treatment options. (archbronconeumol.org)
Idiopathic pulmonary fibrosi3
- Descriptive prospective non-interventional multicenter study based on newly collected data of Idiopathic Pulmonary Fibrosis patients followed-up for one year in secondary care settings (Pu. (bioportfolio.com)
- Could prominent airway-centered fibroblast foci in lung biopsies predict underlying chronic microaspiration in idiopathic pulmonary fibrosis patients? (elsevier.com)
- These findings suggest that in combined lung cancer and idiopathic pulmonary fibrosis patients, the features of the lung cancer are similar to the total lung cancer population. (ersjournals.com)
- Data from patients with pulmonary fibrosis, who reported starting treatments within the last 5 years. (patientslikeme.com)
- Review: Current drug treatments do not reduce mortality in idiopathic pulmonary fibrosis. (nih.gov)
- Differentiation of fibrosis is important because treatments are different as well as prognosis. (jabfm.org)
- research:the pulmonary fibrosis foundation (pff) places enormous importance on creating an environment that will assist in the development of effective treatments for pulmonary fibrosis (pf). (greatnonprofits.org)
- Idiopathic pulmonary fibrosis (IPF), the prototype of interstitial lung diseases, has the worst prognosis and is the only interstitial lung disease for which approved pharmacological treatments are available. (biomedcentral.com)
- The few available antifibrotic treatments modify the rate of fibrosis progression, but there are no available treatments to reverse established fibrosis. (jci.org)
Treat idiopathic pulmonar1
Department of Pulmonary Medicine1
- Telomerase and ET-1 expression was inversely correlated with minimal fibrosis in areas of fibroblast foci and directly associated with severe fibrosis in vascular areas. (scielo.br)
- a)-(c): Photomicrographs demonstrate active young fibroblast proliferation (fibrosis) and tumor cells that are entrapped within the central desmoplasia. (hindawi.com)
- Mechanisms leading to fibroblast accumulation during pulmonary fibrogenesis remain unclear. (pnas.org)
- Pulmonary fibrosis is characterized by fibroblast proliferation and extracellular matrix remodelling, leading to respiratory insufficiency. (nature.com)
- PI3K/AKT acts upstream of ER stress to affect lung fibroblast proliferation, resulting in bleomycin-induced pulmonary fibrosis. (nature.com)
- Treatment with ER stress inhibitors or a PI3K inhibitor caused a reduction in fibroblast proliferation and improved pulmonary function. (nature.com)
- ER stress is also involved in lung fibrosis through the control of fibroblast proliferation and myofibroblastic differentiation 16 . (nature.com)
Treated for idiopathic1
European Respiratory Society1
- This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association. (nih.gov)
Forms of interstitial lung di1
- Three of the patients with idiopathic pulmonary fibrosis had desquamative interstitial pneumonia, and the remainder had usual interstitial pneumonia. (nih.gov)
- In this study, we demonstrated the importance of telomerase protein expression and determined the relationships among telomerase, endothelin-1 (ET-1) and myofibroblasts during early and late remodeling of parenchymal and vascular areas in usual interstitial pneumonia (UIP) using 27 surgical lung biopsies from patients with idiopathic pulmonary fibrosis (IPF). (scielo.br)
- The histologic pattern associated with IPF is the usual interstitial pneumonia (UIP), characterized by patchy and temporally heterogeneous fibrosis with excessive extracellular matrix (ECM) and honeycomb change, interspersed with normal and collapsed areas (1). (scielo.br)
- Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis. (ovid.com)
Lead to pulmonary fibrosis1
Cause of pulmonary fibrosis2
People with pulmonary fibrosis2
Familial Pulmonary Fibrosis1
- In a transbronchial biopsy, forceps pass through the bronchoscope to obtain the specimen. (thefreedictionary.com)
- Transbronchial biopsy revealed pulmonary fibrosis with a lymphocytic infiltrate. (bmj.com)
- Transbronchial biopsy had shown a mild chronic inflammatory interstitial infiltrate and mild fibrosis, but no granulomas or vasculitis. (bmj.com)