Sharp instruments used for puncturing or suturing.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Conducting a fine needle biopsy with the aid of ENDOSCOPIC ULTRASONOGRAPHY.
A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).
Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.
The use of needles usually larger than 14-gauge to remove tissue samples large enough to retain cellular architecture for pathology examination.
Infection of the lymph nodes by tuberculosis. Tuberculous infection of the cervical lymph nodes is scrofula.
Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)
Tumors or cancer of the THYROID GLAND.
The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Pathological processes of the BREAST.
Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
Pathological processes involving the THYROID GLAND.
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
Pathological processes of the PANCREAS.
Methods used to study CELLS.
Tumors or cancer of the human BREAST.
An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.
Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)
The removal of secretions, gas or fluid from hollow or tubular organs or cavities by means of a tube and a device that acts on negative pressure.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)
An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)
Tumors or cancer of the PAROTID GLAND.
The part of a human or animal body connecting the HEAD to the rest of the body.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Use of ultrasound for imaging the breast. The most frequent application is the diagnosis of neoplasms of the female breast.
Usage of a single needle among two or more people for injecting drugs. Needle sharing is a high-risk behavior for contracting infectious disease.
A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (From Dorland, 28th ed & Stedman, 26th ed)
Inflammatory diseases of the THYROID GLAND. Thyroiditis can be classified into acute (THYROIDITIS, SUPPURATIVE), subacute (granulomatous and lymphocytic), chronic fibrous (Riedel's), chronic lymphocytic (HASHIMOTO DISEASE), transient (POSTPARTUM THYROIDITIS), and other AUTOIMMUNE THYROIDITIS subtypes.
Disorders of the mediastinum, general or unspecified.
Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).
Surgical removal of the thyroid gland. (Dorland, 28th ed)
Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.
Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.
Tumors or cancer of the MEDIASTINUM.
Endoscopic examination, therapy or surgery of the rectum.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
A rare malignant neoplasm of the sweat glands. It most often develops as a form of degenerative progression from a benign ECCRINE POROMA.
Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).
A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Surgical procedures conducted with the aid of computers. This is most frequently used in orthopedic and laparoscopic surgery for implant placement and instrument guidance. Image-guided surgery interactively combines prior CT scans or MRI images with real-time video.
Endoscopic examination, therapy or surgery of the bronchi.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.
A malignant epithelial tumor with a glandular organization.
Tumors or cancer of the LUNG.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
Tumors or cancer of the UVEA.
Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.
Inflammation of the lymph nodes.
A mass of histologically normal tissue present in an abnormal location.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.
Application of fingers with light pressure to the surface of the body to determine consistence of parts beneath in physical diagnosis; includes palpation for determining the outlines of organs.
A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.
Radiographic examination of the breast.
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)
The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
A type of connective tissue neoplasm typically arising from intralobular stroma of the breast. It is characterized by the rapid enlargement of an asymmetric firm mobile mass. Histologically, its leaf-like stromal clefts are lined by EPITHELIAL CELLS. Rare phyllodes tumor of the prostate is also known.
INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.
Penetrating stab wounds caused by needles. They are of special concern to health care workers since such injuries put them at risk for developing infectious disease.
The conic organs which usually give outlet to milk from the mammary glands.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The sentinel lymph node is the first lymph node to receive drainage from a neoplasm.
Methods of creating machines and devices.
Tumors or cancer of the SALIVARY GLANDS.
Calculi occurring in a salivary gland. Most salivary gland calculi occur in the submandibular gland, but can also occur in the parotid gland and in the sublingual and minor salivary glands.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
A general term for various neoplastic diseases of the lymphoid tissue.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A benign epithelial tumor with a glandular organization.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Liquid material found in epithelial-lined closed cavities or sacs.
A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.
Tumors or cancer of the LIVER.
Elements of limited time intervals, contributing to particular results or situations.
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
A space in which the pressure is far below atmospheric pressure so that the remaining gases do not affect processes being carried on in the space.
Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Neoplasms of the bony orbit and contents except the eyeball.
Incision of tissues for injection of medication or for other diagnostic or therapeutic procedures. Punctures of the skin, for example may be used for diagnostic drainage; of blood vessels for diagnostic imaging procedures.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
Pathological processes of the LIVER.
Tumors or cancer of the SKIN.
A plant species of the genus PINUS that contains isocupressic acid.
All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).
Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.
Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
Tumors or cancer of the PROSTATE.
Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
Minimally invasive procedures guided with the aid of magnetic resonance imaging to visualize tissue structures.
DNA present in neoplastic tissue.
Apparatus, devices, or supplies intended for one-time or temporary use.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Techniques used mostly during brain surgery which use a system of three-dimensional coordinates to locate the site to be operated on.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
Surgical procedure to remove one or both breasts.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. They are evergreen trees mainly in temperate climates.
Introduction of substances into the body using a needle and syringe.
Tapping fluid from the subarachnoid space in the lumbar region, usually between the third and fourth lumbar vertebrae.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
A plant species of the genus PINUS which is the source of pinosylvin. It is sometimes called Scotch pine or Scots pine, which is also a common name for other species of this genus.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Production of an image when x-rays strike a fluorescent screen.
Treatment of disease by inserting needles along specific pathways or meridians. The placement varies with the disease being treated. It is sometimes used in conjunction with heat, moxibustion, acupressure, or electric stimulation.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Space between the dura mater and the walls of the vertebral canal.
Particles of any solid substance, generally under 30 microns in size, often noted as PM30. There is special concern with PM1 which can get down to PULMONARY ALVEOLI and induce MACROPHAGE ACTIVATION and PHAGOCYTOSIS leading to FOREIGN BODY REACTION and LUNG DISEASES.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Biochemical identification of mutational changes in a nucleotide sequence.
The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.
Antibodies produced by a single clone of cells.
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.
The application of electronic, computerized control systems to mechanical devices designed to perform human functions. Formerly restricted to industry, but nowadays applied to artificial organs controlled by bionic (bioelectronic) devices, like automated insulin pumps and other prostheses.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Relating to the size of solids.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Analgesia produced by the insertion of ACUPUNCTURE needles at certain ACUPUNCTURE POINTS on the body. This activates small myelinated nerve fibers in the muscle which transmit impulses to the spinal cord and then activate three centers - the spinal cord, midbrain and pituitary/hypothalamus - to produce analgesia.
Inanimate objects that become enclosed in the body.
Endoscopes for the visualization of the interior of the bronchi.
Procedure in which an anesthetic is injected directly into the spinal cord.
Removal of bone marrow and evaluation of its histologic picture.
A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.

Tissue harmonic imaging: utility in breast sonography. (1/1235)

OBJECTIVE: To determine the impact of tissue harmonic imaging on visualization of focal breast lesions and to compare gray scale contrast between focal breast lesions and fatty tissue of the breast between tissue harmonic imaging and fundamental frequency sonography. METHODS: A prospective study was performed on 219 female patients (254 lesions) undergoing sonographically guided fine-needle biopsy. The fundamental frequency and tissue harmonic images of all lesions were obtained on a scanner with a wideband 7.5-MHz linear probe. Twenty-three breast carcinomas, 6 suspect lesions, 9 fibroadenomas, 1 papilloma, 1 phyllodes tumor, 162 unspecified solid benign lesions, and 40 cysts were found. In 12 cases the fine-needle aspiration did not yield sufficient material. The gray scale intensity of the lesions and adjacent fatty tissue was measured with graphics software, and the gray scale contrast between lesions and adjacent fatty tissue was calculated. RESULTS: Tissue harmonic imaging improved the gray scale contrast between the fatty tissue and breast lesions in 230 lesions (90.6%; P < .001) compared with fundamental frequency images. The contrast improvement was bigger in breasts with predominantly fatty or mixed (fatty/glandular) composition than in predominantly glandular breasts. The overall conspicuity, lesion border definition, lesion content definition, and acoustic shadow conspicuity were improved or equal in the harmonic mode for all lesions. CONCLUSIONS: The tissue harmonic imaging technique used as an adjunct to conventional breast sonography may improve lesion detectability and characterization.  (+info)

Adenomatoid tumor of the pancreas: a case report with comparison of histology and aspiration cytology. (2/1235)

We present a 58-year-old woman who presented with a 1.5-cm, hypodense lesion in the head of the pancreas. Endoscopic ultrasound-guided fine-needle aspiration yielded bland, monotonous cells with wispy cytoplasm, slightly granular chromatin, and small nucleoli. A presumptive diagnosis of a neuroendocrine lesion was rendered. Whipple procedure yielded a well-circumscribed, encapsulated lesion with dense, hyalinized stroma and a peripheral rim of lymphocytes. Spindled and epithelioid cells formed short tubules, cords, and nests. The neoplasm stained for CK 5/6, calretinin, vimentin, CD 99, pancytokeratin, and EMA, consistent with mesothelial origin. This characteristic histology and immunohistochemistry is consistent with an adenomatoid tumor. We believe we are the first to report this benign neoplasm in such an unusual location. Herein we address the diagnosis of adenomatoid tumor by histology, immunohistochemistry, and aspiration cytology. Our case is particularly unique in that the histology and cytology are compared and correlated.  (+info)

Computed tomography-guided biopsy of mediastinal lesions: fine versus cutting needles. (3/1235)

PURPOSE: To report the experience of a radiology department in the use of computed tomography guided biopsies of mediastinal lesions with fine and cutting needles, describing the differences between them. The results of adequacy of the sample and histologic diagnoses are presented according to the type of needle used. METHODS: We present a retrospective study of mediastinal biopsies guided by computed tomography performed from January 1993 to December 1999. Eighty-six patients underwent mediastinal biopsy in this period, 37 with cutting needles, 38 with fine needles, and 11 with both types (total of 97 biopsies). RESULTS: In most cases, it was possible to obtain an adequate sample (82.5%) and specific diagnosis (67.0%). Cutting-needle biopsy produced a higher percentage of adequate samples (89.6% versus 75.5%, P = 0.068) and of specific diagnosis (81.3% versus 53.1%, P = 0.003) than fine-needle biopsy. There were no complications that required intervention in either group. CONCLUSION: Because they are practical, safe, and can provide accurate diagnoses, image-guided biopsies should be considered the procedure of choice in the initial exploration of patients with mediastinal masses. In our experience, cutting needles gave higher quality samples and diagnostic rates. We recommend the use of cutting needles as the preferred procedure.  (+info)

Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors. (4/1235)

PURPOSE: The purpose of this study was to determine whether comprehensive transcriptional profiles (TPs) can be obtained from single-passage fine-needle aspirations (FNAs) of breast cancer and to explore whether profiles capture routine clinicopathological parameters. EXPERIMENTAL DESIGN: Expression profiles were available on 38 patients with stage I-III breast cancer who underwent FNA at the time of diagnosis. [(33)P]dCTP-labeled cDNA probes were generated and hybridized to cDNA membrane microarrays that contained 30,000 human sequence clones, including 10,890 expressed sequence tags. RESULTS: The median total RNA yield from the biopsies was 2 micro g (range, 1-25 micro g). The cellular composition of each biopsy was examined and, on average, 79% of the cells were cancer cells. TP was successfully performed on all 38 of the biopsies. Unsupervised complete-linkage hierarchical clustering with all of the biopsies revealed an association between estrogen receptor (ER) status and gene expression profiles. There was a strong correlation between ER status determined by TP and measured by routine immunohistochemistry (P = 0.001). A similar strong correlation was seen with HER-2 status determined by fluorescent in situ hybridization (P = 0.0002). Using the first 18 cases as the discovery set, we established a cutoff of 2.0 and 18.0 for ER and HER-2 mRNA levels, respectively, to distinguish clinically-negative from -positive cases. We also identified 105 genes (excluding the ER gene) the expression of which correlated highly with clinical ER status. Twenty tumors were used for prospective validation. HER-2 status was correctly identified in all 20 of the cases, based on HER-2 mRNA content detected by TP. ER status was correctly identified in 19 of 20 cases. When the marker set of 105 genes was used to prospectively predict ER status, TP-based classification correctly identified 9 of 10 of the ER-positive and 7 of 10 of the ER-negative tumors. We also explored supervised cluster analysis using various functional categories of genes, and we observed a clear separation between ER-negative and ER-positive tumors when genes involved in signal transduction were used for clustering. CONCLUSIONS: These results demonstrate that comprehensive TP can be performed on FNA biopsies. TPs reliably measure conventional single-gene prognostic markers such as ER and HER-2. A complex pattern of genes (not including ER) can also be used to predict clinical ER status. These results demonstrate that needle biopsy-based diagnostic microarray tests may be developed that could capture conventional prognostic information but may also contain additional clinical information that cannot currently be measured with other methods.  (+info)

Endoscopic transesophageal and endoscopic transbronchial real-time ultrasound-guided biopsy. (5/1235)

The goal of preoperative staging of non-small-cell lung cancer is to identify patients who will benefit from surgical resection. Various imaging and less invasive modalities are now available to improve therapy decision-making, and with the introduction of multimodality treatment of lung cancer, proper staging of this disease is becoming more and more important. This staging process is therefore not only a question of determining the prognosis, but it is also necessary information for institution of the right treatment. Proper staging and restaging of lung cancer should also be a must in the evaluation of the different treatments of lung cancer in controlled clinical trials. In lung cancer, endoscopic ultrasound scanning (EUS) is emerging as an accurate, nonsurgical alternative to staging the mediastinum through EUS-fine-needle aspiration (EUS-FNA). The author presents publications on evaluating EUS in diagnosing lymph node involvement in lung cancer and tumor ingrowths in the mediastinum. With EUS it is possible to guide FNA with direct visualization of the needle path into the lymph nodes in real time. Although this method is only able to visualize the posterior path and the inferior parts of the mediastinum, it makes it possible to visualize the aortopulmonary window. The limitation of EUS is a sensitivity of about 90%; nonetheless, this method is more precise than other staging procedures except for mediastinoscopy, which is limited to only the anterior parts of the mediastinum.  (+info)

Detection of gene promoter hypermethylation in fine needle washings from breast lesions. (6/1235)

PURPOSE: Fine needle aspiration (FNA) is used widely in diagnostic assessment of breast lesions. However, cytomorphological evaluation depends heavily on the proficiency of cytopathologists. Because epigenetic alterations are frequent and specific enough to potentially augment the accuracy of malignant disease detection, we tested whether hypermethylation analysis of a panel of genes would distinguish benign from malignant breast FNA washings. EXPERIMENTAL DESIGN: FNA washings were collected from 123 female patients harboring suspicious mammary lesions. Sodium bisulfite-modified DNA was amplified by methyl-specific PCR (MSP) for CDH1, GSTP1, BRCA1, and RARbeta to detect gene promoter CpG island methylation. Paired samples of 27 breast cancer tissue and 7 fibroadenomas and 12 samples of normal breast tissue, collected postoperatively, were also analyzed. MSP results were compared with conventional cytomorphological diagnosis. RESULTS: FNAs were cytomorphologically diagnosed as benign (25 cases), malignant (76 cases), suspicious for malignancy (6 cases), and unsatisfactory (16 cases). Percentages of methylated CDH1, GSTP1, BRCA1, and RARbeta in FNA washings were 60, 52, 32, and 16%, and 65.8, 57.9, 39.5, and 34.2% for benign and malignant lesions, respectively. These differences did not reach statistical significance. In all of the paired benign lesions tested, there was absolute concordance. Sixty-seven percent (18 of 27) of FNA washings displayed hypermethylation patterns identical to malignant paired tissue. No methylation was found in the normal breast samples for any of the genes. CONCLUSIONS: Detection of gene hypermethylation in FNA washings by MSP analysis is feasible, but the selected gene panel does not discriminate between benign and malignant breast lesions.  (+info)

BREASTAID: Clinical results from early development of a clinical decision rule for palpable solid breast masses. (7/1235)

OBJECTIVE: To develop a clinical decision rule (entitled BREASTAID) that will predict the probability of malignancy in women with palpable solid breast masses. SUMMARY BACKGROUND DATA: Currently, 80% of open breast biopsies are benign, resulting in excessive economic, psychologic, and physical morbidity. METHODS: A total of 452 solid breast masses were evaluated in a surgical breast clinic between November 1994 and February 1998. Breast cancer status was defined histologically as ductal carcinoma in situ or invasive cancer. Noncancer status included benign histology, mass resolution, or stability at 12-month follow-up. Data were collected on risk factors, clinical breast examination, mammography, and cytology results. Three multiple logistic regression models were used to generate the probability of cancer at 3 logical steps in the workup; Bayes' theorem was applied in a stepwise fashion to generate a final probability of cancer. RESULTS: A model incorporating only clinical breast examination and mammography resulted in an excessive number of either missed cases or biopsies compared with one that included cytology. Using a cut-point of 4%, this latter BREASTAID model had 97.6% sensitivity and 85.1% specificity. Compared with triple diagnosis, BREASTAID would have reduced the open biopsy rate from 39.8% (180 of 452) to 22.3% (101 of 452), improving the diagnostic yield from 22.7% to 40.6%. CONCLUSIONS: This study convincingly demonstrates that at minimum, clinical, radiologic, and cytologic evaluations are required to accurately evaluate a solid breast mass. BREASTAID has the potential to minimize the number of open biopsies performed while allowing safe triage to follow-up. Before widespread application, further validation studies are required.  (+info)

Yield of endoscopic ultrasound-guided fine-needle aspiration biopsy in patients with suspected pancreatic carcinoma. (8/1235)

BACKGROUND: Although atypical or suspicious cytology may support a clinical diagnosis of a malignancy, it is often not sufficient for the implementation of therapy in patients with pancreatic carcinoma. Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is a relatively new method for obtaining cytology samples, and one that may decrease the number of atypical/suspicious diagnoses. The goals of the current study were to prospectively evaluate the yield of EUS-FNAB in the diagnosis of patients presenting with solid pancreatic lesions and to evaluate the significance of atypical, suspicious, and false-negative aspirates. METHODS: All patients who presented with a solid pancreatic lesion and underwent EUS-FNAB over a 13-month period were included in the current study. One endoscopist performed all EUS-FNABs. On-site evaluation of specimen adequacy by a cytopathologist was available for each case. Follow-up included histologic correlation (n = 21) and clinical and/or imaging follow-up (n = 80), including 38 patients who died of the disease. RESULTS: EUS-FNABs were obtained from 101 patients (mean age, 62 +/- 11.8 years; age range, 34-89 years). The male-to-female ratio was 2:1. Sixty-five percent of the lesions were located in the head of the pancreas, 12% were located in the uncinate, 17% were located in the body, and 6% were located in the tail. The mean size of the tumors was 3.3 cm (range, 1.3-7 cm). A median of 4 needle passes were performed (range, 1-11 needle passes). Sixty-two biopsies (61.4%) were interpreted as malignant on cytologic evaluation, 5 (5%) as suspicious for a malignancy, 6 (5.9%) as atypical/indeterminate, and 26 (25.7%) as benign processes. Of the 76 malignant lesions, 71 were adenocarcinomas, 3 were neuroendocrine tumors, 1 was a lymphoma, and 1 was a metastatic renal cell carcinoma. All except one of the suspicious/atypical aspirates were subsequently confirmed to be malignant. Agreement was complete for the atypical cases. Among the suspicious cases, 2 of the 5 were identified as carcinoma by one cytopathologist and as suspicious lesions by the other, yielding a 40% disagreement rate between the 2 cytopathologists. Therefore, for the 10 atypical or suspicious cases that later were confirmed to be malignant, the final diagnosis of malignant disease was not made due to scant cellularity that could be attributed to sampling error in 8 cases and to interpretative disagreement in 2 cases (20%). All four false-negative diagnoses were attributed to sampling error. Two percent of all biopsies were inadequate for interpretation. Of the 99 adequate specimens, 72 yielded true-positive results, 23 yielded true-negative results, and 4 yielded false-negative results. No false-positives were encountered. Therefore, the sensitivity, specificity, positive predictive value, and negative predictive value of EUS-FNAB for solid pancreatic masses were 94.7% (95% confidence interval [CI], 89.7-99.8%), 100%, 100%, and 85.2% (95% CI, 71.8-98.6%), respectively. CONCLUSIONS: EUS-FNAB is a safe and highly accurate method for tissue diagnosis of patients with solid pancreatic lesions. Patients with suspicious and atypical EUS-FNAB aspirates deserve further clinical evaluation.  (+info)

Looking for online definition of endoscopic ultrasound-guided fine-needle aspiration in the Medical Dictionary? endoscopic ultrasound-guided fine-needle aspiration explanation free. What is endoscopic ultrasound-guided fine-needle aspiration? Meaning of endoscopic ultrasound-guided fine-needle aspiration medical term. What does endoscopic ultrasound-guided fine-needle aspiration mean?
TY - JOUR. T1 - Quantitative examination of mechanophysical tumor cell enrichment in fine-needle aspiration specimens. AU - Ernst, Linda M.. AU - Rimm, David L.. PY - 2002/10/25. Y1 - 2002/10/25. N2 - BACKGROUND. The advent of cDNA microarrays and other molecular technologies necessitates the acquisition of tumor cell-enriched material because nonmalignant cells often decrease the sensitivity of the assays. Fine-needle aspiration (FNA) specimens from carcinoma have long been noted to be enriched in malignant cells. The current study quantitated the relative representation of tumor versus nontumor cells in FNA specimens compared with tissue sections using breast carcinoma as a model. METHODS. Five patients who had undergone both a diagnostic FNA and a surgical excision for breast carcinoma between January and July of 1996 were selected. Five random cellular fields from representative slides of the FNA (using the ThinPrep preparation of the wash) and surgical excision specimens were photographed ...
TY - JOUR. T1 - Anaplastic thyroid cancer. T2 - Ultrasonographic findings and the role of ultrasonography-guided fine needle aspiration biopsy. AU - Suh, Hee Jung. AU - Moon, Hee Jung. AU - Kwak, Jin Young. AU - Choi, Ji Soo. AU - Kim, Eun Kyung. PY - 2013. Y1 - 2013. N2 - Purpose: To investigate the ultrasonographic (US) features of anaplastic thyroid cancer (ATC) and the diagnostic performance of US-guided fine needle aspiration biopsy (FNAB) therein. Materials and Methods: Eighteen cases of ATC diagnosed between January 2001 and May 2011 were included. FNAB was performed in all cases. Initial FNAB results were divided into three groups: 1) the cytological ATC group, cytological diagnosis of ATC; 2) the underestimated group, cytological diagnoses of malignancy other than ATC; and 3) the false negative group, cytological diagnoses of atypical, benign and non-diagnostic lesions. We retrospectively reviewed US findings and compared treatment modalities between each group. Results: Among the 18 ...
Evaluation of the effectivity of the new thyroid fine needle aspiration biopsy (FNAB) apparatus of which patented from Turkish Patent Institute.
The aim of this study was to compare the results of palpation-versus ultrasound-guided thyroid fine-needle aspiration (FNA) biopsies. Clinical data, cytology and histopathology results were retrospectively analyzed on all patients who underwent thyroid FNA biopsy in our outpatient endocrinology clinic between January 1998 and April 2003. The same investigators performed all thyroid FNAs (ASC) and cytological evaluations (KP). Subjects in the ultrasound-guided group were older, otherwise there were no differences in baseline characteristics (gender, thyroid function, the frequency of multinodular goiter, nodule diameter and nodule location) between groups. Cytology results in nodules aspirated by palpation (n = 202) versus ultrasound guidance (n = 184) were as follows: malignant 2.0% versus 2.7% (p = 0.74), benign 69.8% versus 79.9% (p = 0.02), indeterminate 1.0% versus 4.9% (p = 0.02), inadequate 27.2% versus 12.5% (p | 0.01). Malignant results were compared with Fishers exact test. Other cytology
Fine-needle aspiration biopsy of lymph nodes. Fine-needle aspiration biopsy (FNAB), when performed by trained operators, and for the correct indications, is a safe and minimally invasive procedure, with an excellent diagnostic ...
TY - JOUR. T1 - Complications of ultrasound-guided fine-needle biopsy of the spleen. T2 - Report on 110 patients and review of the literature. AU - Di Stasi, M.. AU - Buscarini, L.. AU - Cavanna, L.. AU - Rossi, S.. AU - Buscarini, E.. AU - Silva, M.. PY - 1996. Y1 - 1996. N2 - The data on 110 patients who underwent ultrasound-guided fine-needle biopsies of the spleen (either with focal lesions or with a homogeneous echo pattern) were reviewed. Aspiration needles were employed in 41% of the biopsies and cutting needles in 59%. All patients were assessed 24 h after the biopsy by clinical examination, abdominal ultrasound and a full blood count. Only one minor complication occurred, that of a spontaneously resolving subcapsular haematoma undetected at the assessment 24-h post-FNB, which was subsequently diagnosed 1 week post biopsy. Eight other similar series were found in the literature. In these series, five non-fatal complications were reported out of a total of 364 patients (morbidity rate ...
TY - JOUR. T1 - Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management. AU - Faulkner-Jones, Beverly E.. AU - Foster, William J.. AU - Harbour, J. William. AU - Smith, Morton E.. AU - Dávila, Rosa M.. PY - 2005/1/1. Y1 - 2005/1/1. N2 - Objective: To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors. Study Design: Thirty-three consecutive adults undergoing FNAB of suspected intraocular tumors were studied. Clinical, cytologie and histologic diagnoses were correlated. The positive predictive value, sensitivity and specificity of FNAB for detecting malignancy, the effeet of IHC on the final cytologic diagnosis and the number of patients in whom clinical management was altered as a result of cytologic evaluation were determined. Results: The positive predictive value was 96% with and 93% without adjunct IHC. The sensitivity and specificity of FNAB for ...
A total of 113 fine needle aspirates of the breast masses were evaluated in which the subsequent biopsy or mastectomy specimen were also available for histological examination. The age ranged from 16 to 80 years with a mean of 42 years. In benign conditions the mean age was 34.7 years while in malignant cases it was 48 years. The cytological diagnoses were compared with the histological results which revealed that the specificity and sensitivity of fine needle aspiration cytology in the palpable breast lesions was 86.1% and 89.2% respectively with a positive predictive value of 93% and efficiency of 88.2%. Similar statistics from other series in which the cytological results of breast lesions were compared with histological results, revealed almost same results which suggest that fine needle aspiration cytology is an effective and accurate technique for the diagnosis and management of palpable breast lumps.
Fingerprint Dive into the research topics of Ultrasound-guided fine-needle aspiration biopsy of internal mammary nodes: Technique and preliminary results in breast cancer patients. Together they form a unique fingerprint. ...
Fine needle aspiration cytology and flow cytometry immunophenotyping of non-Hodgkin lymphoma: can we do better?. Objective: To evaluate the diagnostic efficiency of fine needle aspiration cytology/flow cytometry (FNAC/FC) in the diagnosis and classification of non-Hodgkin lymphoma (NHL) in a series of 446 cases and to compare the results with those of previous experiences to evaluate whether there had been an improvement in FNAC/FC diagnostic accuracy.. Methods: FNAC/FC was used to analyse 446 cases of benign reactive hyperplasia (BRH), NHL and NHL relapse (rNHL) in 362 lymph nodes and 84 extranodal lesions. When a diagnosis of NHL was reached, a classification was attempted combining FC data and cytological features. Sensitivity, specificity and positive and negative predictive values (PPV and NPV) of FNAC/FC in the diagnosis and classification of NHL were calculated and compared with those available in the literature.. Results: FNAC/FC provided a diagnosis of NHL and rNHL in 245 cases and of ...
Fine needle aspiration cytology (FNAC) and open biopsy of same enlarged lymph nodes were performed in 59 patients with lymphadenopathy. When histopathological and cytological examinations were compared, an accuracy of 91.5% was achieved with FNAC in the cases of lymphadenopathy of various etiologies. Thus, fine needle aspiration cytology being reliable, safe, rapid and economical procedure, is useful as an outdoor diagnostic procedure for diagnosing lymphadenopathy of various etiologies.
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The study by Zevallos et al., aimed to determine if the increased thyroid cancer incidence observed corresponded with a similar increase in the use of diagnostic investigations. Thyroid ultrasound and fine needle aspiration. This was achieved by examining the Veterans Affairs health system records. The number of cases of thyroid cancer and the numbers of diagnostic investigations performed in the period between the years 2000 and 2012 were compared. At the commencement of the study in 2000, the incidence of thyroid cancer was 10.3 cases per 100,000 people. In comparison, at the studys conclusion in 2012, the incidence of thyroid cancer was 21.5 cases per 100,000 people.. As with the incidence of thyroid cancer during the study period, the use of ultrasound and fine needle aspiration biopsy also exhibited an increase. In 2000, the rate of thyroid ultrasound was 125.6 per 100,000 people, which had increased to 572.1 per 100,000 people in 2012. Similarly, in 2000 the rate of fine needle ...
South Korea has experienced rapid modernization both socially and economically, leading to the improved health status of South Koreans but an
SUMMARY: The use of transoral sonography-guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. There were 14 patients with a history of thyroid cancer, 7 with mucosal squamous cell carcinoma, 1 with renal cell carcinoma, 1 with parotid acinic cell cancer, 1 with metastatic colon adenocarcinoma, and 2 with no history of cancer. Intraoperative transoral sonography was performed using a commercially available endovaginal transducer. A transoral sonography-guided fine-needle aspiration was performed with a 25-cm-long 20-ga Chiba needle through a needle guide attached to the transducer shaft. Cytopathologic results were categorized as malignant, benign, or nondiagnostic. Transoral sonography ...
Results The final diagnosis was adenocarcinoma in 156 patients (67%), neuroendocrine tumor in 27 (12%), lymphoma in 6 (3%), metastatic malignancy in 8 (4%), and benign etiologies in 35 (15%). CP was identified in 44/234 (19%) patients. The overall diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for EUS-FNA were 92.9%, 97.1%, 99.5%, 70.8%, and 93.5%, respectively. The sensitivity (80% vs. 95%, P=0.020) and accuracy (86% vs. 95%, P=0.043) were significantly lower in patients with CP compared to those without CP. ...
In a great majority of cases, uveal tumours are diagnosed and treated based solely upon clinical examination and ancillary diagnostic studies such as ultrasonography and angiography.1 In general, diagnostic fine needle aspiration biopsy (FNAB) is limited to situations presenting as a diagnostic dilemma such as differentiation between an amelanotic uveal melanoma and a metastatic uveal tumour.2-5 The other major indication for ophthalmic FNAB is for prognostication purposes of uveal melanoma being treated with radiation therapy.6. Most ophthalmic surgeons have used available needles without customisation ranging in size from 22 gauge (G) to 30G, with the 25G needle being the most commonly used.2 7 8 … ...
A fine needle aspiration biopsy (FNAB)) device was designed to utilize a steel spring located between the syringe and its plunger which exerts a constant negative pressure (auto-vacuum). In 43 rats inoculated with breast tumor cells the technique was compared with the standard procedure of FNAB (21 Sp1 and 22 Walker 256 carcinosarcoma). Malignant cells were cytologically confirmed in all cases. Sufficient material was obtained in 95% of FNAB by auto-vacuum system versus 86% by standard technique. The superior results obtained with the auto-vacuum system was seen for both soft and hard tumours ...
In this blog, Neighborhood Radiology Services in metro New York explain more about fine needle aspiration biopsy, including how long the procedure takes:
Learn all about the thyroid Fine Needle Aspiration Biopsy (FNAB) from preparing for the procedure to what to expect after it is finished.
Fine-needle aspiration biopsy (FNAB) of the breast is a minimally invasive yet maximally diagnostic method. However, the clinical use of FNAB has been questioned. The purpose of our study was to establish the overall value of FNAC in the diagnosis of breast lesions. After a review and quality assessment of 46 studies, sensitivity, specificity and other measures of accuracy of FNAB for evaluating breast lesions were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize overall accuracy. The sensitivity and specificity for the studies data (included unsatisfactory samples) and underestimation rate of unsatisfactory samples were also calculated. The summary estimates for FNAB in diagnosis of breast carcinoma were as follows (unsatisfactory samples was temporarily exluded): sensitivity, 0.927 (95% confidence interval [CI], 0.921 to 0.933); specificity, 0.948 (95% CI, 0.943 to 0.952); positive likelihood ratio, 25.72 (95% CI, 17.35 to 28.13); negative
TY - JOUR. T1 - Characterization of endoscopic ultrasound fine-needle aspiration cytology by targeted next-generation sequencing and theranostic potential. AU - Gleeson, Ferga C.. AU - Kipp, Benjamin R.. AU - Kerr, Sarah E.. AU - Voss, Jesse S.. AU - Lazaridis, Konstantinos N.. AU - Katzka, David A.. AU - Levy, Michael J.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Determination of tumor genetic architecture based on tissue analysis yields important information on signaling pathways involved in cancer pathogenesis and plays a growing role in choosing the optimal medical management of malignancies. Specifically, the advent of next-generation sequencing has led to a rapidly evolving era of relatively inexpensive, high-throughput DNA sequencing of tumors. One such example is multiplexed tumor genotyping (ie, panel testing) of more than 2800 mutations across 50 commonly mutated cancer-associated genes. This resulting mutational landscape shows medically actionable pathogenic alterations to optimize ...
By Dr Rishu Agarwal, MD (Pathology)Fine needle aspiration cytology (FNAC) is a diagnostic procedure where a needle is inserted into your body, and a small amount of tissue is sucked out for examin
TY - JOUR. T1 - Fine-needle biopsy of chest lesions. AU - Samuelsson, L.. AU - Albrechtsson, U.. AU - Tylen, Ulf. PY - 1982. Y1 - 1982. UR - UR - M3 - Article. C2 - 7178480. AN - SCOPUS:0020412864. VL - 22. SP - 493. EP - 496. JO - Der Radiologe. JF - Der Radiologe. SN - 0033-832X. IS - 11. ER - ...
By Liang-Che Tao. The target of this booklet is to proportion authors mixed 30 years event within the fine-needle aspiration biopsy analysis of organs underneath the diaphragm with normal pathologists. ranging from the fundamentals, this publication progresses to in-depth cytomorphologic research with histologic and immunohistochemical affirmation of particular entities. Cytohistological correlation is emphasised by utilizing composite photos from both resected tumor or the mobilephone block each time attainable. ...
HTGFN : An adjunct to cytologic examination of fine-needle aspiration specimens in athyrotic individuals treated for differentiated thyroid cancer, to confirm or exclude metastases in enlarged or ultrasonographically suspicious lymph nodes   This test is not useful for screening asymptomatic individuals for neoplastic disease.
This book discusses a broad selection of interesting cases of fine needle aspiration cytology (FNAC), which offer valuable insights into the diagnosis of cytology cases in routine practice. It provide
Read The coherence between fine needle aspiration cytology and histopathology of palpable neck nodes in lower lip carcinoma patients, European Journal of Plastic Surgery on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Optimizing the development of targeted agents in pancreatic cancer: Tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays Academic Article ...
To the editor: In their evaluation of fine-needle aspiration biopsies of lymph nodes in patients with the acquired immunodeficiency syndrome (AIDS)-related conditions, Bottles and colleagues (1) emphasize the usefulness of this method for diagnosing malignancy, Kaposi sarcoma, and mycobacterial infection. We report a case in which the diagnosis of disseminated cryptococcosis was made on the basis of a routine May-Grünwald-Giemsa-stained lymph node specimen from fine-needle aspiration biopsy.. A 33-year-old black patient from Angola had lost weight and had night sweats and fever. Physical examination showed cervical, nontender small lymph nodes (0.5 to 1 cm). Mild splenomegaly was present. ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
PURPOSE: To report on the heterogeneity of monosomy 3 in a fine needle aspiration biopsy obtained transsclerally from choroidal melanoma for prognosis. METHODS: All clinical records for patients who had been diagnosed with choroidal melanoma and underwent iodine-125 plaque brachytherapy with intraoperative transscleral fine needle aspiration biopsy from January 2005 to August 20, 2011, and who had a positive result for monosomy 3 according to fluorescence in situ hybridization as reported by clinical cytogenetics testing were collected. Patient age and sex, total number of cells evaluated and number of cells positive for monosomy 3, tumor size, and metastatic outcome were recorded for each patient. RESULTS: A positive result for monosomy 3 was reported in 93 patients who underwent transscleral fine needle aspiration biopsy. Two patients were lost to follow-up immediately post-operatively, and the remaining 91 patients were included in this study. The mean number of cells evaluated in the biopsy ...
To date several published series have documented the difficulty in diagnosing follicular patterned lesions of the thyroid in cytology preparations 513-15]. The histologic follow-up of cases diagnosed as follicular lesions of neoplasm includes hyperplastic/adenomatoid nodules, follicular adenoma, follicular carcinoma and follicular variant of papillary carcinoma 615]. An earlier study published by Schlinkert et al from Mayo clinic showed that only 12% cases diagnosed as suspicious for follicular neoplasm on FNA were malignant on histologic follow-up. Interestingly, 27% were papillary carcinomas (majority were follicular variant) 4. Tuttle et al reported malignancy rate of 21% in their series of 149 patients diagnosed as follicular neoplasm on cytology 8. In our previous study the malignancy rate was 31% in 122 patients diagnosed as follicular neoplasm and almost half of these cases were follicular variant of papillary carcinoma.. In view of these above-mentioned studies we retrospectively ...
Most of pancreatic masses are represented by neoplastic processes, primarily ductal adenocarcinoma and less frequently neuroendocrine tumor, lymphoma and metastasis. On the contrary, non neoplastic lesions are represented by chronic, autoimmune pancreatitis and cysts [1, 2]. Pancreatic cancer is the fourth and fifth most common cancer in men and women respectively [3]. Due to local invasion or distant metastasis, only 15-20% of patients are surgical candidates at presentation. Among them, the 5-year survival rate is only 10-15% [4]. About 70% of pancreatic cancers develop in the head while 10-20% in the body and tail [5]. In many cases, pancreatic cancer is diagnosed in the advanced stage of the disease and at this point the tumor cannot be submitted to surgical resection. In fact, at the moment of diagnosis, 52% patients show distant disease and 26% have regional spread [6]. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a rapid, safe, cost-effective and accurate technique to evaluate
Purpose To study cytomorphology and cytologic diagnostic criteria of bone malignant lymphoma(MLB) by fine needle aspiration cytology(FNAC). Methods To use multiform stainings to observe the cytologic samples and compared with histologic results of same patients to analyse the morphologic appearances. Results Of eight cases of bone non Hodgkins lymphoma, seven were accurately diagnosed by FNAC, they showed monotypic immatare lymphocytes in cytomorphology. Conclusion The cytologic result to diagnose MLB by FNAC is dependable. The diagnostic basis of cytomorphology is consistent with cytologic diagnostic criteria of lymphoma.
TY - JOUR. T1 - Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules. T2 - Results of a multicenter study. AU - Natali, P. G.. AU - Mottolese, M.. AU - Perrone Donnorso, R.. AU - Buffa, R.. AU - Bussolati, G.. AU - Coggi, G.. AU - Corradi, G.. AU - Coscia-Porrazzi, L.. AU - Ferretti, M.. AU - Rondanelli, E.. AU - Castagna, M.. AU - Vecchione, A.. AU - Siccardi, G. A.. PY - 1990. Y1 - 1990. N2 - Fine-needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre-surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 FNAs, show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% ...
Boland MR, Prichard RS;Daskalova I;Lowery AJ;Evoy D;Geraghty J;Rothwell J;Quinn CM;ODoherty A;McDermott EW (2015) Axillary nodal burden in primary breast cancer patients with positive pre-operative ultrasound guided fine needle aspiration cytology: management in the era of ACOSOG Z011. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 41 (4):559-565. [DOI] [Details] ...
TY - JOUR. T1 - Stability of DNA, RNA, cytomorphology, and immunoantigenicity in residual thinprep® specimens. AU - Kim, Younghye. AU - Choi, Kap Ro. AU - Chae, Moon Jung. AU - Shin, Bong Kyung. AU - Kim, Han Kyeom. AU - Kim, Aeree. AU - Kim, Baek hui. PY - 2013/11. Y1 - 2013/11. N2 - The aim of this study was to evaluate the quality of residual liquid-based preparation (LBP) sample after cytopathologic diagnosis. Cervical swab, body fluid, and thyroid fine-needle aspiration (FNA) samples preserved in ThinPrep PreservCyt® solution were tested. Samples kept frozen at -80 °C and stored at room temperature were tested 12 months after the initial sample collection. Gel electrophotography of GAPDH multiplex PCR, RNA integrity number (RIN) values obtained from Agilent bioanalyzer, cytomorphologic changes, and immunohistochemical staining (cytokeratin, thyroid transcription factor-1 (TTF-1), and D2-40) were used for the evaluation of sample quality. All available samples showed successful ...
1. Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011 Jan; 35(1):15-25. 2. Tacha D, et al. A Six Antibody Panel for the Classification of Lung Adenocarcinoma versus Squamous Cell Carcinoma. Appl Immunohistochem Mol Morphol. 2012 May; 20(3):201-7. 3. Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol. 2007 Dec; 15(4):415-20. 4. Khayyata S, et al. Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. Diagn Cytopathol. 2009 Mar; 37:178-83. 5. Terry J, et al. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol. 2010 Dec; ...
Here's what you should know regarding fine needle aspiration biopsies of thyroid nodules to diagnose or rule out thyroid cancer.
title:Fine Needle Aspiration Cytology of Neck Lesion- An Experience at Tertiary Care Hospital in Central Gujarat. Author:Chauhan Savitri, Darad Dimple, Dholakia Aditi. Keywords:Aspiration, Lymphnode, Histologically, FNAC. Type:Original Article. Abstract:Introduction: Fine needle aspiration cytology has become a rapid, cost effective investigative method for obtaining reliable tissue diagnosis especially for the sites like neck where considerable overlapping of various structures makes it difficult to reach to exact diagnosis. Objective: Present study was taken up to evaluate role of FNA in management and diagnosis of various neck lesions and to compare FNA with conventional biopsy for providing correct tissue diagnosis. Method: Total 641 cases of neck lesions were subjected to FNA and out of these, 71 were further subjected to conventional surgical biopsy and results were correlated histologically. FNACs were performed in outpatient department of a tertiary care hospital by 23-24 gauge needle ...
What is the effect of ultrasound-guided needle dye injection in localization of intraoperative tumors? Background: Locating and surgically excising non-palpable neck tumors in an accurate, efficient and safe manner, particularly in previously operated areas, can be a challenge. Preoperative imaging with computed tomography, magnetic resonance, positron emission tomography, or ultrasound-guided fine-needle aspiration biopsy are tools typically […]. ...
A 40-year-old Caucasian female presented with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1-month period. There was no personal or family history of malignancy or diabetes mellitus. On examination, she was jaundiced with pale mucous membranes and capillary glucose was 23.1 mmol/L. Initial investigations showed iron deficiency anaemia and obstructive pattern of liver function tests. HbA1c was diagnostic of diabetes mellitus at 79 mmol/mol. Malignancy was suspected and CT chest, abdomen and pelvis showed significant dilatation of intra- and extra-hepatic biliary tree including pancreatic duct, with periampullary 30 mm mass lesion projecting into lumen of duodenum. Enlarged nodes were seen around the superior mesenteric artery. This was confirmed on MRI liver. Fasting gut hormones were normal except for a mildly elevated somatostatin level. Chromogranin A was elevated at 78 pmol/L with normal chromogranin B. Duodenoscopy and biopsy showed possible tubovillous adenoma with ...
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UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Womens Health, Oncology, Pediatrics, Pulmonary, Critical Care, Sleep Medicine, Rheumatology, Surgery, and more.
PUBLICATIONS, RESEARCH PROJECTS, ACHIEVEMENTS & AWARDS. 1) Toshniwal H P, Chada P K. Evaluation of Male Infertility and Physiological Role of Zinc. International Journal of Scientific Research. March 2016, 5 (3): 44-46. ISSN No. 2277-8179. 2) Chada P K, Toshniwal H P. Evaluation of Glycated Haemoglobin and Risk of Microalbuminuria in Patient with type II Diabetes Mellitus International Journal of Scientific Research. May 2016, 5 (3): 73-76. ISSN No. 2277-8179. 3) Toshniwal H P, Chada P K. Evaluation of serum Iron and Copper status in Pregnant Women with Iron Deficiency Anaemia. Global Journal for Research Analysis. April 2016, 5 (3): 75-78. ISSN No. 2277-8160.. 4) Toshniwal H P, Chada P K. Study on Sensitivity and Specificity of Thyroid lesion on Fine Needle Aspiration Cytology: A Hospital Based Study Global Journal for Research Analysis. March 2016, 5 (3): 65-68. ISSN No. 2277-8160.. 5) Toshniwal S H, Toshniwal H P. Evaluation of Incidental Findings of tumour in Cholecystectomy cases in ...
Background and Aim: A recently carried out randomized controlled trial showed the benefit of a novel 20-G fine-needle biopsy (FNB) over a 25-G fine-needle aspiration (FNA) needle. The current study evaluated the reproducibility of these findings among expert academic and non-academic pathologists. Methods: This study was a side-study of the ASPRO (ASpiration versus PROcore) study. Five centers retrieved 74 (59%) consecutive FNB and 51 (41%) FNA samples from the ASPRO study according to randomization; 64 (51%) pancreatic and 61 (49%) lymph node specimens. Samples were re-reviewed by five expert academic and five non-academic pathologists and rated in terms of sample quality and diagnosis. Ratings were compared between needles, expert academic and non-academic pathologists, target lesions, and cytology versus histological specimens. Results: Besides a higher diagnostic accuracy, FNB also provided for a better agreement on diagnosing malignancy (ĸ = 0.59 vs ĸ = 0.76, P , 0.001) and classification ...
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TY - JOUR. T1 - Predictive factors for inaccurate diagnosis of swollen lymph nodes in endoscopic ultrasound-guided fine needle aspiration. AU - Fujii, Yuki. AU - Kanno, Yoshihide. AU - Koshita, Shinsuke. AU - Ogawa, Takahisa. AU - Kusunose, Hiroaki. AU - Masu, Kaori. AU - Sakai, Toshitaka. AU - Yonamine, Keisuke. AU - Kawakami, Yujiro. AU - Murabayashi, Toji. AU - Kozakai, Fumisato. AU - Noda, Yutaka. AU - Okada, Hiroyuki. AU - Ito, Kei. N1 - Publisher Copyright: © 2019 Korean Society of Gastrointestinal Endoscopy.. PY - 2019. Y1 - 2019. N2 - Background/Aims: This study aimed to identify the predictive factors for inaccurate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) diagnosis of swollen lymph nodes without rapid on-site cytopathological evaluation. Methods: Eighty-three consecutive patients who underwent EUS-FNA for abdominal or mediastinal lymph nodes from January 2008 to June 2017 were included from a prospectively maintained EUS-FNA database and retrospectively reviewed. ...
TY - JOUR. T1 - Is pancreatitis a complication of endoscopic ultrasound guided fine needle aspiration of the pancreas?. AU - Gress, F.. AU - Ikenberry, S.. AU - Ciaccia, D.. AU - Kiel, J.. AU - Lehman, Glen. PY - 1997. Y1 - 1997. N2 - Introduction: Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of the pancreas is increasingly being utilized to diagnose pancreatic masses. We have previously reported 2 cases of clinical pancreatitis following EUS guided FNA of the pancreas. Aim of Study: To determine the frequency of chemical and clinical pancreatitis following EUS guided FNA of the pancreas. Methods: All patients having EUS guided FNA biopsy of the pancreas were eligible. Exclusion criteria included: All patients with acute pancreatitis or having ERCP within 48 hours of the EUS FNA. Serum amylase and lipase levels were measured immediately prior to and 2 hours post EUS FNA. Patients were called 24-72 hours after FNA to follow up for increased pain, nausea, or vomiting suggesting ...
The aspiration smear revealed low cellularity with a clean background devoid of mucin. A few small collections of cuboidal epithelial cells with uniform round nuclei and pale cytoplasm were observed (Fig. 2A). The nuclear membranes were smooth, the chromatin was finely granular, and the nucleoli were small. The nuclear-cytoplasmic ratio was low. In a liquid-based preparation, two different cell populations were identified. The first population was composed of loose cell clusters of cuboidal cells with small, round nuclei and undefined cell borders (Fig. 2B). Sheets of atypical cells with disorderly arranged nuclei, occasional nuclear overlapping and nuclear grooves comprised the second cell population (Fig 2C). The cell borders were relatively well defined. These atypical cells were regarded as low-grade adenocarcinoma cells during the initial cytological diagnosis, but they were identified as gastric epithelial cells with degenerating atypia during retrospective review. Epithelial sheets with ...
TY - JOUR. T1 - Ultrasound-guided fine needle aspiration versus core needle biopsy. T2 - comparison of post-biopsy hematoma rates and risk factors. AU - Chae, In Hye. AU - Kim, Eun Kyung. AU - Moon, Hee Jung. AU - Yoon, Jung Hyun. AU - Park, Vivian Y.. AU - Kwak, Jin Young. N1 - Publisher Copyright: © 2017, Springer Science+Business Media New York.. PY - 2017/7/1. Y1 - 2017/7/1. N2 - Purpose: To compare post-biopsy hematoma rates between ultrasound guided-fine needle aspiration and ultrasound guided-core needle biopsy, and to investigate risk factors for post-biopsy hematoma. Methods: A total of 5304 thyroid nodules which underwent ultrasound guided biopsy were included in this retrospective study. We compared clinical and US features between patients with and without post-biopsy hematoma. Associations between these features and post-biopsy hematoma were analyzed. Results: Post-biopsy hematoma rate was 0.8% (43/5121) for ultrasound guided-fine needle aspiration and 4.9% (9/183) for ultrasound ...
Castlemans disease (CD) is an uncommon lymphoproliferative disorder typically presenting as Mediastinal lymph node swelling. Clinical presentation can range from asymptomatic to generalised lymphadenopathy and hepatosplenomegaly. Two histological variants are hyaline vascular type and plasma cell type. Hyaline vascular type CD presents as unicentric mass mimicking various infectious and malignant causes of lymphadenopathy. Cytological features vary depending upon the extent of the lesion, thus, fine needle aspiration cytology (FNAC) is not always conclusive and histopathology is required to reach a definitive diagnosis. Here we present a case of unicentric castlemans disease (UCD) diagnosed on FNAC with histological correlation.. ...
Objectives To evaluate the effectiveness of fine-needle aspiration cytology (FNAC) & ultrasound scanning (US) in the diagnosis and management of solitary thyroid nodules.. Materials & Methods A retrospective study was carried out on 63 patients who were euthyroid and had a clinically palpable solitary thyroid nodule, who underwent either total or hemi-thyroidectomy, during a period of two years (January 2018 to December 2019) in the ENT unit of a tertiary care hospital in Sri Lanka. All patients with FNAC of Bethesda ≥5 underwent total thyroidectomy. Diagnostic hemi-thyroidectomy was performed only in patients with a FNAC of Bethesda ≤4, irrespective of US suspicious features.. Results Mean age was 46.9 years (±13.2). 53(84.1%) patients were females and 10 (15.9%) of them were male. 28(44.4%) patients had histologically proven malignancy while the other 35(55.6%) had benign histology. Sensitivity, specificity, positive predictive values and negative predictive values for FNAC and ultrasound ...
article{b4dd06dd-ccd1-448e-9856-ef0297979410, abstract = {,p,For preoperative localization of enlarged parathyroid glands, several imaging techniques have been used. In this study we demonstrate the feasibility of using ultrasonography with fine needle aspiration for parathyroid hormone assay as a preoperative localization procedure in 21 patients with primary hyperparathyroidism. A single adenoma was found in 18 patients while 3 patients had multiglandular disease. Ultrasonically guided fine needle biopsy was possible in 11 cases. In 8 of these aspirates, a high parathyroid hormone content was found. In all 8 cases the localization was confirmed at surgery. We conclude that the efficiency to preoperatively localize enlarged parathyroid glands is enhanced by fine needle aspiration.,/p,}, author = {Bergenfelz, A and Forsberg, L and Hederström, Esbjörn and Ahrén, B}, issn = {0284-1851}, keyword = {Adult,Aged,Aged, 80 and over,Biopsy, Needle,Female,Humans,Hyperparathyroidism,Male,Middle ...
Objective: We aimed to investigate the ultrasound (US) features and malignancy rates of thyroid nodules, below and above 1 centimeter diameter, according to fine needle aspiration biopsy (FNAB) results.. Materials and Methods: Total 157 nodular goiter patients, 60 patients nodules were below 1 cm and 97 patients nodules were above 1 cm, analyzed retrospectively. The nodules with pure cystic, peripheral calcification and inadequate cytological result were excluded. As a malignancy criterion at US, including hypo echoic pattern, solid structure, micro calcification features of nodule and not having peripheral halo feature of nodule were used. In statistical analyze, P,0.05 was accepted as significant.. Results: The malignancy or suspicions cytology rate was found 5% in nodules with below 1 cm, 17.5% in nodules with above 1 cm (total malignancy or suspicions cytology rate: 12.7%) and statistically it was not observed significant difference (P=0.548). The statistical significant differences was not ...
Fine-needle aspiration biopsy (FNAB) of the thyroid gland is the most cost-effective examination in the evaluation of thyroid nodules. The aim of this study was to present our experience from all patients who underwent thyroid FNA in the University Hospital of Ioannina, Greece, in the period 1993-2003, and its value in the diagnostic management of patients with thyroid nodules. FNA was performed in 900 patients of whom 753 were females and 147 males. The cases were classified according to diagnosis into five groups: benign/negative 628, primary carcinoma 28, metastatic carcinoma 5, suspicious/indeterminate 60 and non-diagnostic 179. Cytological findings were compared with histopathological findings and the statistical analysis in our data yielded the following results: sensitivity 92.1%, specificity 93.2%. These results are in accordance with the already published data in the international literature. In cases of differential diagnosis between adenomatoid hyperplasia and follicular neoplasia, ...
TY - JOUR. T1 - Fine needle aspiration cytology of a male breast carcinoma exhibiting neuroendocrine differentiation. T2 - Report of a case with immunohistochemical, flow cytometric and ultrastructural analysis. AU - Feczko, J. D.. AU - Rosales, R. N.. AU - Cramer, H. M.. AU - Goulet, R. J.. AU - Tao, L. C.. PY - 1995. Y1 - 1995. N2 - We present the cytologic, immunohistochemical, flow cytometric and ultrastructural findings of a case of invasive ductal carcinoma of the breast with features of neuroendocrine differentiation occurring in an 83-year-old male. Fine needle aspiration (FNA) cytology of the patients tumor demonstrated a markedly cellular specimen of discohesive tumor cells, present primarily singly, with occasional loose groups. The cells were relatively large, with pleomorphic, eccentrically placed, round to oval nuclei. The cytoplasm was abundant and contained prominent red granules (Papanicolaou stain) that were also argyrophilic. Immunohistochemical studies performed on the ...
Endoscopic ultrasound-guided sampling of solid pancreatic masses: the fine needle aspiration or fine needle biopsy dilemma. Is the best needle yet to come?
MRI depicts a 3 cm submucosal lesion on the anterior wall of the rectum, located 8.5 cm from the anal verge. The lesion has circumscribed smooth margins with intermediate signal intensity on T1-weighted images (Figure 1), low signal on T2-weighted images (Figure 2a, 2b) and low signal intensity on Diffusion Weighted Imaging with high b-value (Figure 3). Intravenous Gadolinium post contrast study revealed no contrast uptake (Figure 5). An endoscopic ultrasound-guided fine needle aspiration biopsy was suggested (Figure 6). There was also a small nodular focus, deep on the recto-uterine pouch, of high sinal intensity on T1-weighted fat-saturated images (Figure 4 ...
The optimum technique for biopsy assessment of the nature of a major salivary gland mass remains controversial. Fine needle aspiration cytology (FNAC) has been the traditional and popular choice, but sampling of cellular clusters is largely associated with high non-diagnostic and false-negative rates, even under optimised circumstances. Ultrasound-guided core biopsy (USCB) provides a core of tissue that allows preservation of tissue architecture and that can be histologically and immunohistochemically examined, thereby improving the chances of a meaningful diagnosis. Although relatively recently applied in the pre-operative investigation of salivary lesions, USCB shows higher levels of accuracy and reduced non-diagnostic rates when compared with FNAC, in addition to good patient tolerability. A degree of caution should, however, be exercised because of the potential for tumour seeding, and time delays inherent to histological processing are also unavoidable. Where available, USCB may be given preference
Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As approximately 25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a pre-operative clinical setting, including considerations regarding cost-effectiveness, availability, and feasibility of combining techniques. Addressed diagnostics include gene mutation analysis, microRNA, immunocytochemistry, ultrasonography, elastosonography, CT, sestamibi scintigraphy, FDG-PET and diffusion-weighted MRI.The best rule-out tests for malignancy were the Afirma® GEC and FDG-PET. The most accurate rule-in test was sole BRAF mutation analysis. No diagnostic had both near-perfect sensitivity and specificity, and ...
Before the 1980s, the application of diagnostic cytology in Taiwan was limited to exfoliative cytology, such as sputum, body fluid, and Pap test. The utilization of interventional cytology began with thyroid FNA. Prof. Tien-Chun Chang, an endocrinologist at National Taiwan University Hospital, is considered to be the pioneer of thyroid FNA in Taiwan. In 1979, he performed the first thyroid FNA on a patient with follicular thyroid carcinoma. After this initial attempt, which demonstrated promising diagnostic value, he began an on-site aspiration and cytologic diagnosis service at bedsides and in his thyroid clinic. Instead of using standard May-Grünwald-Giemsa staining, which usually takes less than 10 minutes, he applied Liu staining on cytologic smears, which produced similar staining quality for rapid diagnosis [3]. The Liu stain is a modified Romanowsky stain invented by Prof. Chen-Hui Liu in 1953 for hematologic smears. The entire staining procedure is simple and takes only 2 minutes [3]. ...
Price of a print issue: €25.00 AIM: The aim of this study is to compare the diagnostic accuracy in detecting axillary node metastases between preoperative ultrasound with percutaneous core biopsy or fine needle aspiration cytology, in patients with breast cancer. MATERIAL AND METHODS: All cases with newly diagnosed ipsilateral primary breast cancer that underwent axillary ultrasound guided biopsies in a 2 year period were reviewed and the biopsy outcome was compared to the final histopathology from sentinel lymph node biopsy or axillary node dissection. Comparison was also attempted in a subgroup including only patients who underwent one method and in a second subgroup of patients who had both techniques performed. RESULTS: Within the total population results are in favor of core biopsy which correlates statistically significantly with the final histology after excluding neoadjuvant related false negatives. Within the single modality subgroup results are again in favor of core biopsy which ...
TY - JOUR. T1 - Early detection of occult thyroid cancer metastases in small cervical lymph node by genetic analysis of fine-needle aspiration specimens. AU - Lee, M. T.. AU - Lin, S. Y.. AU - Yang, H. J.. AU - Lee, T. I.. AU - Lin, H. D.. AU - Tang, K. T.. PY - 2000. Y1 - 2000. UR - UR - M3 - Article. C2 - 11108495. AN - SCOPUS:0033672041. VL - 29. SP - 322. EP - 326. JO - Journal of Otolaryngology - Head and Neck Surgery. JF - Journal of Otolaryngology - Head and Neck Surgery. SN - 1916-0208. IS - 5. ER - ...
Background: Differentiating potentially malignant thyroid nodules among those undetermined by cytology avoid unnecessary surgical procedures. Aberrant DNA methylation is ubiquitous in human cancers, including thyroid tumors. Biomarkers based on methylation profiles have been successfully used to diagnose early stage malignancy in many human cancers.. Objective and hypotheses: To determine the genome-wide promoter methylation status of cytologically indeterminate thyroid nodules.. Methods: We obtained genomic DNA from frozen samples of three classical (CV PTC) and three follicular variant papillary (FV PTC), two follicular adenomas (FA) and three adenomatous goiter (AG) removed from 11 unrelated patients. The DNA methylation fraction was enriched using methyl-DNA immunoprecipitation and interrogated on Affymetrix human promoter 1.0 array. For control, DNA from normal thyroid tissue patients were also extracted and pooled in a single reaction. All array data analysis were performed using ...
A randomised prospective comparison of liquid-based cytology with conventional smear cytology for endoscopic ultrasound-guided fine needle aspiration of solid pancreatic ...
Author: Prakash H MuddeGowda , Jyothi B Lingegowda , Shankar S Hiremath , Kishanprasad HL , Dr.Ramaswamy AS , Aravinda P. Category: Pathology. [Download PDF]. Abstract:. Background :. Fine needle aspiration cytology is a diagnostic tool used in the clinical workup of solitary thyroid nodules, to triage them into operative and non-operative lesions, as they have higher incidence of malignancy.. Methods :. Prospective study to find the utility of fine needle aspiration cytology (FNAC) in solitary thyroid nodules,. conducted at JJM Medical College, Davanagere. Fine needle aspiration specimens from 162 patients with solitary thyroid nodule were analyzed. In 70 patients histopathological study was made and cytohistopathological correlationwas done.. Results:. Out of 162 cases, female sex was found predominant (87.65%) and mean age of the patients was 35.67 yrs. Sensitivity, specificity and efficacy of the study for malignancy were 66.66%, 98.4% and 95.71% respectively.. Conclusions:. Although FNAC is ...
Background: Lymphadenopathy is a common clinical problem in our country among all age groups and in both sexes. In this study an attempt has been made to evaluate the clinical presentation and diagnosis of peripheral lymphadenopathy, which is commonly encountered in medical wards and diagnostic value of FNAC has been evaluated.. Methodology: This hospital-based descriptive study was done in thirty adult cases, of clinically apparent peripheral lymphadenopathy of at least more than two weeks of duration. Study was conducted over a period of 6 months from July, 2005 to December, 2005 in inpatients and outpatients of Rajshahi Medical College Hospital. After thorough examination, fine needle aspiration from several accessible enlarged lymph node groups were taken and sent for cytopathological examination and later biopsy of the significantly enlarged lymph node from the same anatomical region was performed and was sent for histopathological examination.. Results: Cytopathological study was ...
TY - JOUR. T1 - Comparison of differential diagnostic capabilities of 201Tl scintigraphy and fine-needle aspiration of thyroid nodules. AU - Okumura, Yoshihiro. AU - Takeda, Yoshihiro. AU - Sato, Shuhei. AU - Komatsu, Megumi. AU - Nakagawa, Tomio. AU - Akaki, Shiro. AU - Kuroda, Masahiro. AU - Joja, Ikuo. AU - Hiraki, Yoshio. PY - 1999/12/1. Y1 - 1999/12/1. N2 - We assessed the ability of 201Tl planar scintigraphy and fine-needle aspiration (FNA) biopsy to differentiate malignant from benign lesions by comparing the findings of these techniques with those of surgical histopathology for 107 patients with 109 thyroid nodules. Methods: 201Tl (74 MBq) was injected intravenously, and an early image and a delayed image were acquired after 10 and 120 min, respectively, for 10 min each. For 201Tl planar scintigraphy, accumulation of the tracer in the nodules was visually scored and the nodules were grouped. Group A showed high activity in both early and delayed images. Group B revealed high activity in ...
We present here a first-of-its-kind assay by which miRNA material is successfully extracted from routinely stained FNA cytology smears and classified as suspicious for malignancy by miRNA profiling or benign. In contrast to currently available tests,6 ,8 ,9 ,30 the test presented here does not require an additional FNA biopsy and can be performed on the same specimen as that initially used to categorise the sample as indeterminate. In addition, this test does not require specially designated preservation material, or unique shipment conditions. Instead, a single routinely prepared cytological slide, stained with Papanicolaou stain or Romanowsky type stains (Diff-Quik and Giemsa), can be used. The test does not require a large amount of cytological material, and the failure rate is quite low if there is minimal adequate cellularity, with 94% of the samples in the validation set being successfully processed.. The assays performance was evaluated based on a validation set composed of blinded, ...
These data suggest consideration of a more conservative approach for most patients with thyroid nodules that are cytologically indeterminate on fine-needle aspiration and benign according to gene-expression classifier results. (Funded by Veracyte.).
Of 8,936 endoscopic ultrasound examinations, 73 repeated procedures were identified, and 24 were excluded.. The 49 initial endoscopic ultrasound procedures were done in Indiana or another state, by one of 15 physicians in private practice, or at a teaching hospital.. The researchers performed an endoscopic ultrasound-guided fine-needle aspiration during an initial endoscopic ultrasound in 21 patients.. This method was not attempted in 14 patients.. The principle indication for a repeated endoscopic ultrasound in 35 patients was for an endoscopic ultrasound fine-needle aspiration after the initial tissue sampling was benign, nondiagnostic, or not done.. The researchers noted that a second endoscopic ultrasound had no clinical impact in 37% of patients.. The team found that in the remaining 63% of patients, a repeated endoscopic ultrasound provided a new or changed clinical diagnosis.. Dr DeWitts team commented, In this study, a repeated endoscopic ultrasound at a tertiary-referral center had a ...
Nodules in the thyroid are frequent. Preoperative investigations including fine-needle cytology and ultrasound cannot in all patients rule out malignancy. Thus, surgical excision for histopathologic examination is often needed. In this narrative review, we examine aspects of the surgical management of indeterminate thyroid nodules, using a comprehensive review of the available literature. The authors manually searched PubMed for relevant literature, including recently published guidelines. Hemithyroidectomy without lymph node dissection remains the recommended management in indeterminate thyroid nodules, i.e., the complete removal of one lobe of the thyroid, for indeterminate thyroid nodules, defined as nodules with fine-needle cytology fulfilling the criteria of Bethesda III or IV categories. At surgery, it is important to preserve the recurrent and superior laryngeal nerves, and intraoperative neuromonitoring is a useful adjunct. Recent data also suggest that parathyroid autofluorescent ...
© 2019 American Medical Association. All rights reserved. Importance: Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can be avoided for these patients if the nodules are reliably diagnosed as benign without surgery. Objective: To determine the diagnostic accuracy of a multigene classifier (GC) test (ThyroSeq v3) for cytologically indeterminate thyroid nodules. Design, Setting, and Participants: Prospective, blinded cohort study conducted at 10 medical centers, with 782 patients with 1013 nodules enrolled. Eligibility criteria were met in 256 patients with 286 nodules; central pathology review was performed on 274 nodules. Interventions: A total of 286 FNA samples from thyroid nodules underwent molecular analysis using the multigene GC (ThyroSeq v3). Main Outcomes and Measures: The primary outcome was diagnostic accuracy of the test for thyroid nodules with Bethesda III and IV cytology.
Accurate lymph node staging is essential for adequate prognostication and therapy planning in patients with non-small cell lung cancer (NSCLC). FDG-PET/CT is a sensitive tool for the detection of metastases, including non-palpable supraclavicular lymph node (SCLN) metastases. Histological proof of metastatic spread and mutation analysis is crucial for optimal staging and therapy. The aim of this study was to investigate the value of ultrasound-guided fine needle aspiration cytology (FNAC) and core biopsy (CB) of FDG active, non-palpable SCLNs in patients with suspicion for lung cancer. Twelve consecutive patients with suspected lung cancer and FDG-positive SCLN underwent FNAC (n = 11) and/or CB (n = 10) and were included and evaluated retrospectively in this study. Cytologic and/or histologic evaluation was performed to confirm initially suspected diagnosis (lung cancer), to confirm N3 stage, and to screen for driver mutations in lung adenocarcinoma. FNAC alone showed diagnostic success in 11/11 cases
Introduction: Thyroid nodules are a common clinical problem and Fine Needle Aspiration (FNA) is the principal method used for preoperative diagnosis. This study was designed to evaluate the diagnostic accuracy of FNA for detection of malignancy in thyroid nodules. Materials and Methods: In this retrospective study, 1016 patients with thyroid nodule ...
Recently Columbia oncologists diagnosed a toddler with acute myelogenous leukemia, and thanks to The Sohn Foundation for Precision Medicine, the entire family underwent genetic testing. Three of his siblings were found to have a gene linked to thyroid cancer. Their father was the carrier. Dr. Kuo found a suspicious thyroid nodule in his neck and with ultrasound-guided fine needle aspiration biopsy diagnosed medullary thyroid cancer, a rare and aggressive form of this disease. She operated the following week. With our early intervention, she says, there is a very good chance that the father has been completely cured and will remain cancer-free ...
Objectives Fine-needle aspiration (FNA) of thyroid lesions may result in infarction and diagnostic difficulties on subsequent thyroidectomy specimens. Next-generation sequencing (NGS) methods for detection of hallmark driver BRAF V600E mutations may help characterize such tumors in which histologic alterations preclude definitive tissue diagnosis. Methods Thyroidectomy specimens with both malignant FNA diagnoses and resultant infarction were identified from our institutional database. NGS methods were used to detect BRAF V600E mutations in the infarcted thyroid carcinomas. Results Nine thyroid carcinomas with infarction were characterized as BRAF-like papillary thyroid carcinoma based on molecular driver categorization and histologic diagnosis. BRAF V600E mutations were detected in the infarcted tissue in four (67%) of six lesions. Conclusions We demonstrate detection of hallmark BRAF V600E mutations by NGS within infarcted tissue of thyroid carcinomas after FNA. This suggests a potential ...
Several extrathoracic tumors metastasize to the mediastinum. Mediastinoscopy is the standard method to obtain tissue proof of mediastinal spread, but drawbacks are its invasiveness, requirement for general anesthesia and costs. Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is indicated in lung cancer staging guidelines as a minimally invasive alternative for surgical staging. The diagnostic values in patients with suspected mediastinal metastases and various (previous) extrathoracic malignancies were assessed. ...
2019 Wiley Periodicals, Inc.Background: In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine (RAI) for hyperthyroidism years ago. Methods: Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated with fine-needle aspiration biopsy (FNAB) were included in the study. Results: There were 27 patients (22 female and 5 male) with a mean age of 59.3 ± 13.5. The indication for RAI treatment was Graves in 5 (18.6%), toxic nodular or multinodular goiter in 16 (69.2%), and unknown in 6 (22.2%) patients. A total of 48 thyroid nodules were evaluated with FNAB and cytological diagnosis were benign in 24 (50.0%), nondiagnostic in 15 (31.2%), atypia of undetermined significance in 5 (10.4%), suspicous for malignancy in 2 (4.2%), and malignant in 2 (4.2%) nodules. Thyroidectomy was performed in 10 patients, 5 were benign (50.0%), and 5 (50.0%) were malignant ...
Discussion: Adenomyoepithelioma was first reported by Hamperl in 1970 as an uncommon biphasic tumor composed of epithelial and myoepithelial cells (3). Adenomyoepitheliomas usually present as a single circumscribed mammary nodule. The fine needle aspiration findings in adenomyoepitheliomas have been described in only a few reports (1, 2, 4-11). It is important to recognize this entity as the radiologic and cytologic features can mimic malignancy. On cytology single enlarged atypical epithelial cells, presumed to be of myoepithelial origin due to staining with S-100 protein have been noted and led to the erroneous diagnosis of carcinoma (6). Only rarely can this diagnosis be made definitively on fine-needle aspiration biopsy (7). Histologic patterns include the tubular, lobulated and spindle cell variants (12). Biphasic pattern consists of tubules lined by cuboidal or columnar shaped epithelial cells surrounded by myoepithelial cell layer, Malignant adenomyoepitheliomas are usually characterized ...
MPM Medical Supply offers a number of FNA needles used for fine needle aspiration including Chiba Needles, Franseen Needles, and Westcott Needles. Our high-quality aspiration needles can be used for fine needle biopsy procedures and are manufactured in the United States.
OBJECTIVE: Fine-needle aspiration cytology is the risk stratification device for thyroid nodules, and ultrasound elastography isnt useful for the differential diagnosis of thyroid cancer routinely. value elevated from harmless to malignant nodules, and the current presence of Rolapitant autoimmune thyroid illnesses did not influence the outcomes (fine-needle aspiration cytology for the differential medical diagnosis of thyroid nodules, by using surgical pathology being a guide standard. Components AND Strategies Ethics acceptance and consent to participant The initial process from the scholarly research (XPH/CL/15/19 dated Sept 4, 2019) was accepted by the review panel of Xingtai Individuals Hospital. The analysis adheres to the rules from the Building up the Confirming of Observational Research in Epidemiology for cross-sectional research as well as the V2008 Declaration of Helsinki (Chinese language edition). All individuals provided up to date consent for medical diagnosis, radiological ...
The Acquire Pulmonary EBUS-FNB Device is designed to be used with EBUS scopes for fine needle biopsy (FNB) of submucosal and extramural lesions of the tracheobronchial tree and the gastrointestinal tract.
For years, thyroid nodules have been evaluated using fine needle aspiration (FNA). For most patients, this approach works reasonably well. But what about the roughly 30 percent of thyroid nodules characterized as having indeterminate cytology?. ...
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Study methods: To establish FNA biopsy requirements for gene expression-based subtype classification of NSCLC, patients with presumed newly diagnosed NSCLC, where radiographic studies and clinical description favor a probable diagnosis of NSCLC, will undergo FNA biopsy according to current standard techniques . For this part of the study, approximately 40 biopsies of confirmed NSCLC will be collected for analysis.. To define a fixed statistical model of histologic subtype prediction in NSCLC, we will prospectively collect 50 FNAs. These FNAs will represent Adenocarcinoma (AC) and Squamous Cell Carcinoma (SCC) cases at a ratio of approximately 1:1. Additional cases of not otherwise specified (NOS), should they be encountered, may also be collected for later analysis. FNA samples qualified based on cell number or ribonucleic acid (RNA) yield (depending on the findings of our primary objective)will be assayed on the QGS platform. ...
ObjectiveTo evaluate the diagnostic utility of image-guided fine-needle aspiration (FNA) in the head and neck.DesignAll image-guided FNAs of the head and neck p
Thyroid nodules are frequent in general population, found in 3.7-7% of people by palpation and 42-67% by ultrasonography (US). The differential diagnosis ranges from papillary (PC), follicular (FC) and medullary (MC) carcinomas to follicular adenoma (FA) and colloid goitre. Cancer risk in thyroid nodules varies: 5% in masses found by palpation, 1.6-15% by US, 3.9-11.3% by computed tomography (CT), 5-6% by magnetic resonance imaging (MRI) and 30-50% by positron emission tomography (PET). The final diagnosis depends on fine needle aspiration (FNA) findings and histopathology. The recent WHO classification (2017) is based on classic morphology, including assessment of invasion and nuclei. New entities are defined to designate tumours with doubtful invasion or controversial nuclear features. By immunohistochemistry, PC expresses HBME-1, TROP-2, CITED1 and CK19. Notably, PC can stain for CD20. MC is recognised by neuroendocrine differentiation. To distinguish FA vs. FC, evaluation of HBME-1, p27 and galectin
Conclusions.- Identifying factors that affect NGS success rates in cytology specimens is crucial for a better understanding of specimen adequacy requirements and for proper use of limited-volume tissue samples. In our practice, which uses direct smears as well as cell block sections, NGS success rates in core needle biopsy and fine-needle aspiration samples are comparable. The chance of successful testing is further increased by procuring concurrent fine-needle aspiration and core needle biopsy samples. The type of glass slides used for direct smears and the method of tissue extraction affect our DNA yield. Validating a DNA input for cytology samples that is lower than that recommended by the manufacturer has significantly increased our NGS success rate ...
This study will evaluate the technical feasibility of using fine needle aspiration (FNA) of liver tissue to obtain vaniprevir (MK-7009) liver pharmacokinetic (PK) data, working towards identifying a minimally invasive, reproducible platform to measure liver PK. The study will be done in 2 parts. In Part 1, participants will be randomized to one of five FNA/core needle biopsy (CNB) time-point collection sequences. In Part 2, participants will be randomized to one of two possible doses of vaniprevir and will be assigned to one of five FNA/CNB time-point collection sequences; participants in Part 2 will also receive background therapy with pegylated interferon alpha-2b (Peg-IFN alpha-2b) and ribavirin (RBV). The primary hypothesis is that there is a greater than 80% posterior probability that vaniprevir concentrations are successfully obtained at least 60% of the time from FNA liver samples collected at 2 of 3 specified timepoints ...
In this present study, we have shown that both RPFNA and DL are highly tolerable procedures (none of our subjects experienced bleeding, pain, or other complications with either procedure), and that once adequate samples are obtained, cytology was similar in DL and RPFNA samples. However, when the entire subject cohort was considered, the success rate of obtaining adequate samples was higher for the RPFNA versus the DL procedure.. Compared with long-term phase III breast cancer prevention trials, the advantage of short-term breast cancer prevention trials is that they do not require a large cohort of participants, are conducted over shorter periods of time, and are therefore more cost-effective. Cancer incidence is not the end point; instead, the aim of short-term prevention trials is to evaluate tissue surrogate end point biomarkers and the effect of potential preventive agents on such biomarkers over time (8). Besides, being used to monitor response to a preventive intervention, biological ...
a b Aziza Nassar Core Needle Biopsy Versus Fine Needle Aspiration Biopsy in Breast-A Historical Perspective and Opportunities ... a b S.-M. Vimpeli, I. Saarenmaa Large-Core Needle Biopsy versus Fine-Needle Aspiration Biopsy in Solid Breast Lesions: ... a b Hukkinen K, Kivisaari L Unsuccessful preoperative biopsies. Fine needle aspiration cytology or core needle biopsy, lead to ... fine needle aspiration biopsy, FNAB)[3]. W krajach zachodnich przeważa biopsja gruboigłowa (ang. core-needle biopsy, CNB)[4] ...
Fine Needle Aspiration. The removal of cells for biopsy, using a needle ...
"Fine needle aspiration biopsy of retinal tumors". Monogr Clin Cytol. Monographs in Clinical Cytology. 21: 72-81. doi:10.1159/ ... "Fine needle aspiration cytology in diagnosis of metastatic sebaceous gland carcinoma of the eyelid to the lymph nodes with ... "Primary Simple Limbal Epithelial Transplantation Along With Excisional Biopsy in the Management of Extensive Ocular Surface ...
The needle used in this procedure is slightly larger than the one used for a fine-needle biopsy because the procedure is ... There are four main types of breast biopsies that may be performed. A fine-needle aspiration biopsy is usually ordered when the ... A newer type of breast biopsy is the stereotactic biopsy that relies on a three-dimensional X-ray to guide the needle biopsy of ... Biopsy or fine needle aspiration are rarely warranted. Fibrocystic breast disease is primarily diagnosed based on the symptoms ...
Fine needle biopsy for cytopathology is also used. Thyroid nodules are extremely common in young adults and children. Almost 50 ... "Fine-Needle Aspiration Biopsy of the Thyroid Gland". Thyroid Disease Manager. Archived from the original on 12 July 2017. ... and for guiding fine needle aspiration cytology (FNAC) or biopsy. Ultrasonographic findings will also guide the indication to ... Fine Needle Aspiration Cytology (FNAC) is a cheap, simple, and safe method in obtaining cytological specimens for diagnosis by ...
Local injury of seminiferous tubules caused by fine-needle biopsies in humans does not cause testicular inflammation (orchitis ... Mallidis C, Baker HW (1994). "Fine needle tissue aspiration biopsy of the testis". Fertility and Sterility. 61 (2): 367-375. ... Experiments in rats have examined, in fine detail, the course of testicular events during a bacterial infection. In the short ... Evidence for their role in the fine regulation of the reproductive endocrine response". European Journal of Endocrinology. 136 ...
Tissue biopsy is often by fine needle aspiration biopsy. Repeated examination may be required. Treatment depends on the ... Yu, YH; Wei, W; Liu, JL (25 January 2012). "Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic ... Biopsy-removal involves using a vacuum-assisted biopsy device to remove the fibroadenoma bit by bit. This procedure can be ... Diagnosis is typically by examination, medical imaging, and tissue biopsy. ...
Diana S. Dean, M.D. Hossein Gharib, M.D. (10 October 2010). "Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d". ... Diana S. Dean, M.D. Hossein Gharib, M.D. (10 October 2010). "Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d". ... the determination of the kind of thyroid nodule is done by fine needle aspiration biopsy. Colloid nodules are distinguished by ...
Diagnosis of benign lesions require a fine-needle-like aspiration biopsy. With various benign lesions, most commonly the ... is inserted into the duct of a salivary gland to assess blockages Biopsy This can be done by fine needle aspiration biopsy, ... A biopsy is crucial in aiding diagnosis. There are common signs that can highlight the presence of a malignant lesion. These ... Salivary gland biopsy with histopathologic examination is needed to make the distinction between whether Sjoren's syndrome or ...
The liver biopsy is a simple procedure done with a fine thin needle under local anaesthesia. The tissue sample is sent to a ... Testing for chronic liver disease involves blood tests, imaging including ultrasound and a biopsy of the liver. ... raised blood lipids Health care professionals who are exposed to body fluids and infected blood Sharing infected needle and ...
A fine needle aspiration (FNA) biopsy can be fast and least painful. A very thin, hollow needle and slight suction will be used ... Using a local anesthetic to numb the skin may not be necessary since a thin needle is used for the biopsy. Receiving an ... injection to prevent pain from the biopsy may be more painful than the biopsy itself. Some men develop a condition known as ...
A fine needle biopsy is often performed to differentiate it from malignancy. v t e. ...
There are three types of biopsies: Fine-needle aspiration, core-needle biopsy and surgical biopsy. The method of biopsy depends ... Fibroadenoma, Fine Needle Aspiration Biopsy (Papanicolou stain). The image shows a sheet of epithelial cells in the typical ... Fibroadenoma, Fine Needle Aspiration Biopsy (Giemsa or DiffQuick stain). The image shows abundant bare bipolar stromal nuclei ... "Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow- ...
Methods used to determine malignancy include fine needle aspirate, biopsy, or complete removal. To determine if the tumor has ...
After detection, the mass is tested using an invasive fine-needle aspiration biopsy. Hürthle cell adenoma is the benign ...
Thyroid tissue may be obtained for biopsy by fine needle aspiration (FNA) or by surgery.[citation needed] Fine needle ... Dean DS, MD, Gharib H. "Fine-Needle Aspiration Biopsy of the Thyroid Gland". The Journal of Clinical Endocrinology & Metabolism ... Needle biopsies became widely used in the 1980s, but it was recognized that the accuracy of identification of cancer was good, ... The reliability of fine needle aspiration is increased when sampling can be guided by ultrasound, and over the last 15 years, ...
Bone biopsy Biopsy Fine-needle aspiration eMedicine "Specialties > Hematology > Diagnostic Procedures > Bone Marrow Aspiration ... Subsequently, the biopsy is performed if indicated. A different, larger trephine needle is inserted and anchored in the bony ... MedlinePlus: Bone marrow biopsy eMedicine: Bone Marrow Aspiration and Biopsy. ... this is the role of bone marrow aspiration and biopsy. Bone marrow samples can be obtained by aspiration and trephine biopsy. ...
"Bone metastasis of glioblastoma multiforme confirmed by fine needle biopsy". Acta Neurochirurgica. 141 (5): 551-52. doi:10.1007 ... The result is then often confirmed by a biopsy.[1] Based on the findings, the tumors are divided into different grades of ... brain tumor can only be confirmed by histological examination of tumor tissue samples obtained either by means of brain biopsy ...
This mass is normally referred to a fine needle aspiration biopsy (FNA) for investigation. FNA accuracy is very high and it is ... Grani, G; Fumarola, A (Jun 2014). "Thyroglobulin in Lymph Node Fine-Needle Aspiration Washout: A Systematic Review and Meta- ...
Analysis with clinicopathologic correlation of 152 fine-needle aspiration biopsies of supraclavicular lymph nodes". Archives of ...
This might be done with scalpel biopsy, punch biopsy, fine or core needle biopsy. In this procedure, the surgeon cuts all, or a ... may also be completed such as fine needle aspiration, biopsy of lymph nodes, and sentinel node biopsy. When the cancer has ... Brush biopsies are not considered accurate for the diagnosis of oral cancer. With the first biopsy, the pathologist will ... Diagnosis is made by biopsy of the concerning area, followed by investigation with CT scan, MRI, PET scan, and examination to ...
Fine needle aspiration (FNA) biopsy: The removal of tissue or fluid using a thin needle. An FNA is the most common type of ... Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer ... biopsy used for salivary gland cancer, and has been shown to produce accurate results when differentiating between benign and ...
Tissue for diagnosis can be obtained via fine-needle aspiration, skin biopsy, or excisional biopsy. Under the microscope, IHs ... Erhardt CA, Vesoulis Z, Kashkari S (2000). "Fine needle aspiration cytology of cellular hemangioma of infancy. A case report". ... A minimally proliferative IH is an uncommon type that presents with fine macular telangiectasias with an occasional bright-red ...
Ultrasonography and fine needle aspiration biopsy (FNAB) are also sometimes helpful in confirming the diagnosis. Enucleation ( ...
Marti, JL; Ayo, D; Levine, P; Hernandez, O; Rescigno, J; Axelrod, DM (2012). "Nonimage-guided fine needle aspiration biopsy of ...
"Preoperative metabolic classification of thyroid nodules using mass spectrometry imaging of fine-needle aspiration biopsies". ... Within her laboratory, the device has been used to analyze human tissue biopsies, including normal and cancerous breast, lung, ... The MasSpec Pen is currently being evaluated for use on freshly excised tissue biopsies and for intraoperative use during ... The device was initially used to analyze 253 human tissue biopsies, including normal and cancerous breast, lung, ovary, and ...
... s can be definitively diagnosed through biopsy, including fine-needle aspiration (FNA), core biopsy, or subtotal ... needle or surgical biopsy, direct washing or brushing of tumor tissue, sputum cytopathology, etc. A pathologist then examines ...
2008). "Evaluation of whole slide image immunohistochemistry interpretation in challenging prostate needle biopsies". Human ... Fine, Jeffrey L.; Grzybicki, Dana M.; Silowash, Russell; Ho, Jonhan; Gilbertson, John R.; Anthony, Leslie; Wilson, Robb; ...
p. 4. ISBN 978-3-13-143161-5. Giorgio Gherardi (14 August 2010). Fine-Needle Biopsy of Superficial and Deep Masses: ...
A core needle biopsy is discouraged except in case a lymph node is not easily accessible. Fine-needle aspiration is only ... an incisional or excisional biopsy is preferred. ...
Breast biopsy *Fine-needle aspiration *Interventions on the Lactiferous ducts *Ductal lavage ...
Thyroid nodule, if fine needle aspirate (FNA) results are unclear[1]. TypesEdit. ... A thyroidotomy can be performed to get access for a median laryngotomy, or to perform a biopsy. (Although technically a biopsy ...
In the eastern portion of their range, there are so few whales that researchers have described it looking for a needle in a ... This information allowed researchers to find visually the whales and photograph, biopsy dart (to collect genetic samples) and ... very fine baleen trapping the copepods, and then out over their large lower lips. ...
Small-cell lung carcinoma (microscopic view of a core needle biopsy). In small-cell lung carcinoma (SCLC), the cells contain ... Fine particulates (PM2.5) and sulfate aerosols, which may be released in traffic exhaust fumes, are associated with slightly ... Techniques used for this include transthoracic needle aspiration, transbronchial needle aspiration (with or without ... It is based on the results of imaging studies (such as CT scans and PET scans) and biopsy results. Surgical staging is ...
Breast biopsy *Fine-needle aspiration. Medical imaging. *X-ray *Mammography. *Xeromammography. *MRI *Breast MRI ...
Early histological features expected to be seen on examination of gynecomastic tissue attained by fine-needle aspiration biopsy ...
Breast biopsy *Fine-needle aspiration *Interventions on the Lactiferous ducts *Ductal lavage ...
Micrograph of melanoma, fine-needle aspiration (FNA), field stain. A malignant epithelial tumor that primarily originates in ... Diagnosis is by biopsy and histopathological examination.[3] Non-invasive skin cancer detection methods include photography, ...
Fine Gael (50). Bailey · Barrett · Breen · Brophy · Bruton · Burke · C. Byrne · Cannon · Carey · Corcoran Kennedy · Coveney · ... Images are used for guidance and the primary instruments used during the procedure are needles and tiny tubes called catheters ... Ultrasound is useful for image-guided interventions like biopsies and drainages such as thoracentesis). Small portable ... Fine Gael (50). Bailey · Barrett · Breen · Brophy · Bruton · Burke · C. Byrne · Cannon · Carey · Corcoran Kennedy · Coveney · ...
Oftentimes a biopsy is performed A fine needle aspiration (FNA) biopsy can be fast and least painful. A very thin, hollow ... Using a local anesthetic to numb the skin may not be necessary since a thin needle is used for the biopsy. Receiving an ... injection to prevent pain from the biopsy may be more painful than the biopsy itself.[25] ... needle and slight suction will be used to remove a small sample from under the nipple. ...
Ultrasounds is useful as a guide to performing biopsies to minimise damage to surrounding tissues and in drainages such as ... PET/MRI fusion, largely practiced in academic and research settings, could potentially play a crucial role in fine detail of ... Images are used for guidance, and the primary instruments used during the procedure are needles and catheters. The images ... With rapid administration of intravenous contrast during the CT scan, these fine detail images can be reconstructed into three- ...
A biopsy by fine needle aspiration, often guided by endoscopic ultrasound, may be used where there is uncertainty over the ... Medical imaging, blood tests, tissue biopsy[3][4]. Prevention. Not smoking, maintaining a healthy weight, low red meat diet[5] ... biopsy).[3][4] The disease is divided into stages, from early (stage I) to late (stage IV).[11] Screening the general ...
Diagnosis of small fiber involvement in peripheral neuropathy may also involve a skin biopsy in which a 3 mm-thick section of ... Symptoms depend on the nerves involved, but may include pain, paresthesia (pins-and-needles), paresis (weakness), hypoesthesia ... Neuropathy may cause painful cramps, fasciculations (fine muscle twitching), muscle loss, bone degeneration, and changes in the ... About 25% of the patients will have evidence of enteropathy on biopsy (CD [celiac disease]) but the presence or absence of an ...
A fine needle aspiration biopsy may be taken concurrently of thyroid tissue to determine the nature of a lesion. These biopsies ... A needle aspiration biopsy may then be performed, and the sample undergoes cytology, in which the appearance of cells is viewed ... which may undergo fine needle aspiration. Thyroid function tests will help reveal whether the nodule produces excess thyroid ...
Types of biopsies include core biopsies, which are obtained through the use of large-bore needles, sometimes under the guidance ... data necessary to establish baseline features of anatomy and physiology so as to increase the accuracy with which early or fine ... Brain biopsy under stereotaxy. A small part of the tumor is taken via a needle with a vacuum system. ... Excisional biopsies of skin lesions and gastrointestinal polyps are very common. The pathologist's interpretation of a biopsy ...
In 1985 a robot, the Unimation Puma 200, was used to orient a needle for a brain biopsy while under CT guidance during a ... and fine instruments, gave an opportunity for highly complex procedures to be completed in a minimally invasive fashion. ... Using the robotic system, gynecologists can perform hysterectomies, myomectomies, and lymph node biopsies.[10] ...
... ultrasound-guided fine needle aspiration of the abscess with an 18 gauge needle, under saline lavage until clear.[38] The ... Mammograms or breast biopsies are normally performed on women who do not respond to treatment or on non-breastfeeding women. ... An abscess (or suspected abscess) in the breast may be treated by ultrasound-guided fine-needle aspiration (percutaneous ... For small breast abscesses, ultrasound-guided fine needle aspiration such as to completely drain the abscess is widely ...
... a procedure known as fine needle aspiration, or fine needle aspiration and cytology-FNAC) to help establish the diagnosis. The ... Other options for biopsy include a core biopsy or vacuum-assisted breast biopsy,[83] which are procedures in which a section of ... Most types of breast cancer are easy to diagnose by microscopic analysis of a sample-or biopsy-of the affected area of the ... One or more lymph nodes may be biopsied during the surgery; increasingly the lymph node sampling is performed by a sentinel ...
Alternatively, a fine-needle aspiration biopsy may be performed and is often used to test masses. ... Incisional biopsies such as punch biopsies are usually contraindicated in suspected melanomas, because of the possibility of ... Biopsy[edit]. Following a visual examination and a dermatoscopic exam,[61] or in vivo diagnostic tools such as a confocal ... the preferred surgical margin for the initial biopsy should be narrow (1 mm). The biopsy should include the epidermal, dermal, ...
For cases suspicious enough to proceed to biopsy, small biopsies can be obtained by core needle or bronchoscopy are commonly ... nodules can also be sampled through the airways using bronchoscopy or through the chest wall using fine-needle aspiration ( ... "Transthoracic needle biopsy with a coaxially placed 20-gauge automated cutting needle: results in 122 patients". Radiology. 198 ... CT guided percutaneous transthoracic needle biopsies have also proven to be very helpful in the diagnosis of SPN.[5] ...
Breast biopsy *Fine-needle aspiration *Interventions on the Lactiferous ducts *Ductal lavage ... Mannu, Gurdeep S.; Navi, Ali; Hussien, Maged (2015). "Sentinel lymph node biopsy before mastectomy and immediate breast ... "Sentinel lymph node biopsy before mastectomy and immediate breast reconstruction may predict post-mastectomy radiotherapy, ...
Elliott Baker's 1964 novel and 1966 film version, A Fine Madness, portrays the dehumanizing lobotomy of a womanizing, ... while sometimes substituting a leucotome for a hypodermic needle, it is estimated that he leucotomised about 100 patients in ... Meningeal biopsy. Spinal cord and spinal canal. *Spinal cord and roots *Cordotomy ...
Fine-needle aspiration biopsy and the diagnosis of thyroid cancer. The British journal of surgery. 1987, 74 (4): 292-296. PMID ... 其他部位包括乳房活檢(英语:breast biopsy)、淋巴结活检(英语:lymph node biopsy)、肌肉活檢(英语:muscle biopsy)及皮膚活檢(英语:skin biopsy) ... 形式包括腦活檢(英语:brain biopsy)、神經活檢(英语:nerve biopsy)及腦膜活檢(英语:meningeal
... and biopsy (FNB) has been widely accepted as a fundamental procedure for the diagnosis and staging of lesions of the ... Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) ... EUS-fine needle aspiration (FNA) vs. EUS-fine needle biopsy ( ... Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and biopsy (FNB) has been widely accepted as a fundamental ... Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination. HPB ( ...
... a team of pediatric pathologists who diagnose a vast array of tissue biopsies. ... Pediatric Fine Needle Aspirate Biopsy Pediatric Fine Needle Aspirate Biopsy Superficial fine needle aspirates of superficially ...
... is a procedure in which a small-caliber needle is placed into a mass, cellular material is removed, and a cytologic diagnosis ... encoded search term (Biopsy%2C Fine Needle%2C Neck Mass) and Biopsy, Fine Needle, Neck Mass What to Read Next on Medscape. ... One fatality resulting from a fine needle biopsy of a neck mass has been reported. The death followed fine needle biopsy of a ... Twenty-one-gauge needles provide more cellular samples than twenty-five-gauge needles in fine-needle aspiration biopsy of the ...
Cells are removed through a small, hollow needle. The sample is sent to the lab for analysis. ... A thyroid fine needle aspiration biopsy is a procedure that removes a small sample of tissue from your thyroid gland. ... What is a thyroid fine needle aspiration biopsy?. A thyroid fine needle aspiration biopsy is a procedure that removes a small ... What are the risks of thyroid fine needle aspiration biopsy?. Thyroid fine needle aspiration biopsy is a very safe procedure, ...
Letter: Fatality after fine-needle aspiration biopsy of liver. Br Med J 1975; 1 :517 ... Letter: Fatality after fine-needle aspiration biopsy of liver.. Br Med J 1975; 1 doi: ...
You have been referred for a Fine Needle Aspiration biopsy (FNA) by your health care provider. This is because a lump was ... Question What is a Fine Needle Aspiration biopsy (FNA)?. Answer. You have been referred for a Fine Needle Aspiration biopsy ( ... Biopsies. What is a Fine Needle Aspiration biopsy (FNA)?. How is the FNA biopsy performed?. How long does it take?. When do I ... Almost all biopsies of suspicious breast masses used to be open surgical biopsies. Now more options are available. Fine needle ...
A biopsy is a procedure to remove and examine a sample of tissue from a lump or suspicious area of the body. Visit Nuffield ... Fine needle biopsy A biopsy is a procedure to remove and examine a sample of tissue from a lump or suspicious area of the body ... What happens during fine needle biopsy?. A local anaesthetic is injected first to numb the area. If the lump is near the ... A fine needle is put into the lump to take a sample of cells. Several samples may be taken. ...
A Diagnostic Approach to Fine Needle Aspiration Biopsy - 1st Edition. Print Book & E-Book. ISBN 9781416057697, 9781455728558 ... Chapter 2: Fine Needle Aspiration Biopsy Cytology of Salivary Gland/Head and Neck Lesions: A Diagnostic Approach Based on ... Chapter 8: Fine Needle Aspiration Biopsy Cytology of Lung/Mediastinum: A Diagnostic Approach Based on Pattern Recognition ... Chapter 3: Fine Needle Aspiration Biopsy Cytology of Lymph Nodes: A Diagnostic Approach Based on Pattern Recognition ...
To determine whether the increasing use of percutaneous fine-needle biopsy of abdominal lesions is associated with an increase ... Complications of percutaneous abdominal fine-needle biopsy. Review Radiology. 1991 Jan;178(1):253-8. doi: 10.1148/radiology. ... To determine whether the increasing use of percutaneous fine-needle biopsy of abdominal lesions is associated with an increase ... Of the 23 instances of needle tract seeding, 10 occurred after biopsies of pancreatic malignancies. The frequencies of needle ...
Learn more about Fine Needle Biopsy at St. Davids HealthCare DefinitionReasons for ProcedurePossible ComplicationsWhat to ... A biopsy is a procedure to remove a tissue sample. In a fine needle biopsy (FNB), fluid and cells are removed with a thin, ... Fine needle aspiration, fluid aspiration, and/or core biopsy. National Institute of Health Patient Education website. Available ... Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. UCSF Health website. Available at: https://www.ucsfhealth. ...
Learn more about Fine Needle Biopsy at St. Davids HealthCare DefinitionReasons for ProcedurePossible ComplicationsWhat to ... A biopsy is a procedure to remove a tissue sample. In a fine needle biopsy (FNB), fluid and cells are removed with a thin, ... Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. University of California San Francisco Medical Center ... Fine needle aspiration, fluid aspiration, and/or core biopsy. National Institute of Health Patient Education website. Available ...
Care guide for Fine Needle Breast Biopsy (Ambulatory Care). Includes: possible causes, signs and symptoms, standard treatment ... Learn more about Fine Needle Breast Biopsy (Ambulatory Care). Micromedex® Care Notes. *Core Needle Breast Biopsy ... What you need to know about a fine needle breast biopsy (FNBB):. A FNBB is a procedure to remove a sample of fluid or tissue ... The biopsy needle may make a hole in your lung and cause trouble breathing. You may need other treatments to fix the hole. ...
A fine needle aspiration biopsy of a thyroid nodule is a simple and safe procedure performed in the doctors office. Typically ... For the biopsy, your doctor will use a very thin needle to withdraw cells from the thyroid nodule. The needle used is smaller ... WHAT IS A FINE NEEDLE ASPIRATION BIOPSY (FNA OR FNAB) OF A THYROID NODULE? ... Fine Needle Aspiration Biopsy of Thyroid Nodules. Procedure and interpretation of results ...
... biopsy if a lump is discovered in your breast. Learn more. ... Your health care providers may refer you for a fine needle ... Your health care providers may refer you for a fine needle aspiration biopsy (FNA) if a lump is discovered in your breast. The ... When carried out by an experienced practitioner, a fine needle aspiration biopsy is virtually free of significant complications ... Biopsy for Breast Cancer Diagnosis: Stereotactic Core Biopsy Stereotactic core biopsy was developed as an alternative to ...
Home , What Is A Fine Needle Aspiration Biopsy? - Dr. Terris (VIDEO). What Is A Fine Needle Aspiration Biopsy? - Dr. Terris ( ... ...
Read our Fine-Needle Aspiration Biopsy of the Breast encyclopedia resources online. ... In a fine-needle aspiration biopsy of the breast, your doctor inserts a thin needle into a lump and removes a sample of cells ... Fine-Needle Aspiration Biopsy of the Breast. Based on a photograph courtesy of the National Cancer Institute. All rights ... Fine-Needle Aspiration Biopsy of the Breast. « Previous Page En Español ...
Advances in molecular diagnostics in the last 15 to 20 years have moved fine-needle aspiration biopsy (FNAB) beyond mere ... noted that core needle biopsies provide a larger sample than fine-needle biopsies but have a much higher complication rate. As ... Fine-Needle Aspiration Biopsy for Ocular and Orbital Tumors Written By: Marianne Doran, Contributing Writer. Interviewing J. ... Advances in molecular diagnostics in the last 15 to 20 years have moved fine-needle aspiration biopsy (FNAB) beyond mere ...
The accuracy of 250 fine needle biopsies of renal tumors.. Wunderlich H1, Hindermann W, Al Mustafa AM, Reichelt O, Junker K, ... Re: The accuracy of 250 fine needle biopsies of renal tumors. [J Urol. 2005] ... After radical or partial nephrectomy 250 renal tumor biopsies were performed in 50 patients. All biopsies were performed by 1 ... Core biopsy of renal lesions is accurate enough for histopathological evaluation and determination of therapeutic procedure. ...
Current and accurate information for patients about thyroid biopsy. Learn what you might experience, how to prepare for the ... What is Ultrasound-Guided Fine Needle Aspiration Biopsy of the Thyroid?. During a fine needle aspiration biopsy of the thyroid ... The needle used is a thin, fine-gauge needle that is smaller in diameter than the needle used in most blood draws (usually a 25 ... An ultrasound-guided fine needle aspiration biopsy uses sound waves to help locate a nodule or abnormality within the thyroid ...
Fine Needle Biopsy. (FNB). by Cynthia M. Johnson, MA. Definition. A biopsy is a procedure to remove a tissue sample. In a fine ... needle_aspiration_biopsy/index.html. Accessed March 26, 2018.. Fine needle aspiration biopsy. American Academy of ... Fine needle aspiration, fluid aspiration, and/or core biopsy. National Institute of Health Patient Education website. Available ... Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. UCSF Health website. Available at: https://www.ucsfhealth. ...
... fine needle aspiration biopsy of orbital lesions is an invaluable adjunct diagnostic technique. In experienced hands, the ... Complications of Fine Needle Aspiration Biopsy of the Orbit Ophthalmology. 1985 Dec;92(12):1768-71. doi: 10.1016/s0161-6420(85) ... When properly used in well-indicated patients, fine needle aspiration biopsy of orbital lesions is an invaluable adjunct ... were seen by an oculoplastic or orbital surgeon in consultation for complications arising from a fine needle aspiration biopsy ...
Solitary pleural amyloid nodules occurring as coin lesions diagnosed by fine-needle aspiration biopsy.. Kaw YT1, Esparza AR. ... This report describes two cases of this entity diagnosed by fine-needle aspiration biopsy in patients without systemic amyloid ...
Evaluation of the effectivity of the new thyroid fine needle aspiration biopsy (FNAB) apparatus of which patented from Turkish ... New Thyroid Fine Needle Biopsy Apparatus. The author group of this investigation produced a new thyroid fine needle aspiration ... New Thyroid Fine Needle Biopsy Apparatus. Trial Phase:. N/A. Minimum Age:. 17 Years. Maximum Age:. 85 Years ... fine needle aspiration biopsy indicated noduler goiter patients. Exclusion Criteria:. - diffuse goiter. ...
... needle_aspiration_biopsy/index.html. Accessed January 13, 2021.. Fine needle aspiration biopsy. American Academy of ... A biopsy is a procedure to remove a tissue sample. In a fine needle biopsy (FNB), fluid and cells are removed with a thin, ... A review of the use of fine-needle aspiration biopsy of mammary tumors for diagnosis and research. Acta Cytologica 2017;61:305- ... Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. UCSF Health website. Available at: https://www.ucsfhealth. ...
... ... BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the preferred modality for the cytological ... The total number of needle passes was 105 in group I (mean 2.14 passes per patient; range one to five needle passes) and 158 in ... This appears to be independent of the total number of needle passes undertaken for tissue sampling. ...
Fine Needle Aspiration Biopsy. As with all forms of cancer, thyroid cancer is diagnosed from the results of a biopsy. To ... To get more details about FNA, read our article about fine needle aspiration biopsy. ... benefit of ultrasound is that it helps doctors accurately guide the needle when they perform a fine needle aspiration biopsy. ... doctors use a fine needle aspiration biopsy (FNA). This is usually the first test doctors will use if they suspect thyroid ...
Fine-Needle Biopsy of Pancreatic Masses Article, Author, and Disclosure Information Author, Article, and Disclosure Information ... Fine-Needle Aspiration Biopsy of the Thyroid: An Appraisal Annals of Internal Medicine; 118 (4): 282-289 ... To see whether fine-needle biopsies of the pancreas guided by endoscopic ultrasound are effective at finding cancer in patients ... Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy of Suspected Pancreatic Cancer Annals of Internal Medicine; 134 ...
of Endoscopic ultrasound-guided fine-needle aspiration biopsy in the gastrointestinal tract. 5 ... The optimal number of fine needle passes during EUS-guided FNA has not been determined in a prospective study. The aim of this ... METHODS: Seven or more passes were made with a fine needle into a variety of lesions during EUS-guided FNA. Adequacy of the ... CONCLUSIONS: During EUS-guided FNA, at least 7 passes with a fine needle into pancreatic and miscellaneous lesions, and 5 ...
of Endoscopic ultrasound-guided fine-needle aspiration biopsy in the gastrointestinal tract. 32 ... Endoscopic ultrasound-guided fine needle aspiration is superior to lymph node echofeatures: a prospective evaluation of ... BACKGROUND AND OBJECTIVE: The additional diagnostic value of endoscopic ultrasound-fine needle aspiration (EUS-FNA) over lymph ... Locations of the biopsied LNs included 31% subcarinal, 21% celiac, 21% peripancreatic, 13% periesophageal, 4.4% aortopulmonary ...
Background Since the development of fine-needle aspiration biopsy (FNAB) techniques, preoperative diagnosis and subsequent ... Twenty-one-gauge needles provide more cellular samples than twenty-five-gauge needles in fine-needle aspiration biopsy of the ... Haddadi-Nezhad S, Larijani B, Tavangar SM et al (2003) Comparison of fine-needle-nonaspiration with fine-needle-aspiration ... Gharib H, Goellner JR (1993) Fine-needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med 118:282-289PubMedGoogle ...
  • Advances in molecular diagnostics in the last 15 to 20 years have moved fine-needle aspiration biopsy (FNAB) beyond mere diagnosis of uveal melanoma and into the realm of personalized prognosis. (
  • Since the development of fine-needle aspiration biopsy (FNAB) techniques, preoperative diagnosis and subsequent strategies for patient treatment have changed and evolved greatly. (
  • 1 In general, diagnostic fine needle aspiration biopsy (FNAB) is limited to situations presenting as a diagnostic dilemma such as differentiation between an amelanotic uveal melanoma and a metastatic uveal tumour. (
  • Presented is a case of a chest wall metastasis due to tumor seeding along the needle tract from a percutaneous fine-needle aspiration biopsy (FNAB) of a lung carcinoma. (
  • Ultrasound-guided fine-needle aspiration biopsy (US-FNAB) is frequently used to characterize thyroid nodules as benign or malignant lesions in adults, but its use in children is not. (
  • Since the first intraocular biopsy performed in 1868 [1] by Hirshberg and experience published by Jackobiec in 1979, fine-needle aspiration biopsy (FNAB) in the eye has been used for several intraocular tumors [2]. (
  • Since then fine-needle aspiration (FNAB) biopsy in the eye, has been used for several intraocular tumors [2]. (
  • The role of fine needle aspiration biopsy (FNAB) in the evaluation of focal liver lesions has evolved. (
  • When a biopsy is indicated, core needle biopsy is favored over FNAB. (
  • Until recently, guided fine needle aspiration biopsy (FNAB) was accepted as a safe procedure to procure tissue diagnosis in the management of patients with focal liver lesions. (
  • Objective: We aimed to investigate the ultrasound (US) features and malignancy rates of thyroid nodules, below and above 1 centimeter diameter, according to fine needle aspiration biopsy (FNAB) results. (
  • To determine if the prognostic value of monosomy 3 testing in fine needle aspiration biopsies (FNAB) of choroidal melanoma can be improved by the inclusion of fluorescent probes specific for the subtelomeric regions of chromosome 6pq. (
  • Fine‐needle‐aspiration biopsy (FNAB) of the liver represents a safe and atraumatic method that allows frequent cytological sampling. (
  • Zurück zum Zitat Dostalova L, Kalfert D, Jechova A, Koucky V, Novak S, Kuchar M et al (2020) The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls. (
  • Fine-needle aspiration biopsy (FNAB) of the breast is a minimally invasive yet maximally diagnostic method. (
  • FNAB is an accurate biopsy for evaluating breast malignancy if rigorous criteria are used. (
  • However, the role of FNAB has been challenged of late by better overall results attained by core biopsies. (
  • With the introduction of stereotactic and ultrasonographically (US) guided methods for nonpalpable lesions, fine-needle aspiration biopsy (FNAB) have been used more widely in the evaluation of nonpalpable breast lesions [ 4 - 6 ]. (
  • Cytological verification of the angiographic, sonographic, and/or intraoperative diagnosis of pancreatic or ampullary carcinoma may be achieved by fine-needle aspiration biopsy (FNAB). (
  • The needle used in FNAB is usually smaller than the type of needle used for taking blood tests. (
  • A hollow "core" needle is used, similar to the one in FNAB, but slightly larger in diameter. (
  • Comparison of endoscopic ultrasonography-guided fine-needle aspiration cytology results with and without the stylet in 3364 cases. (
  • Solymosi T, Toth GL, Bodo M (2001) Diagnostic accuracy of fine needle aspiration cytology of the thyroid: impact of ultrasonography and ultrasonographically guided aspiration. (
  • Gharib H, Goellner JR, Johnson DA (1993) Fine-needle aspiration cytology of the thyroid. (
  • Traditionally, these masses have been evaluated by surgical biopsy or exfoliative cytology. (
  • Biopsy or fine needle puncture (FNP) Cytology and histology. (
  • Background: Core needle biopsy (CNB) and fine needle aspiration cytology (FNAC) are useful methods to diagnose cystic lesions of the breast. (
  • Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy? (
  • While fine-needle aspiration cytology (FNAC) was the only preoperative diagnostic procedure to distinguish benign versus malignant neoplasms over the past decades, core needle biopsy (CNB) has been increasingly used over the last few years. (
  • Neither clinical examination nor imaging studies can substitute for fine-needle aspiration cytology (FNAC) or core needle biopsy (CNB) in the preoperative diagnosis of parotid malignancies. (
  • Ratings were compared between needles, expert academic and non-academic pathologists, target lesions, and cytology versus histological specimens. (
  • US-CNB has diagnostic value similar to that of fine-needle aspiration cytology. (
  • Zurück zum Zitat Shkedy Y, Alkan U, Mizrachi A, Shochat T, Dimitstein O, Morgenstern S et al (2018) Fine-needle aspiration cytology for parotid lesions, can we avoid surgery? (
  • Zurück zum Zitat Henrys CE, Grigg R (2015) Use of fine-needle aspiration cytology in the diagnosis of parotid neoplasms. (
  • BRAFV600E mutation analysis via fine-needle aspiration improved 27.8% of the diagnosis rate of PTMC when combined with cytology. (
  • INTRODUCTION Core needle biopsy (CNB) has progressively replaced fine needle aspiration cytology (FNAC) in the diagnosis of breast lesions. (
  • A sensitivity and specificity comparison of fine needle aspiration cytology and core needle biopsy in evaluation of suspicious breast lesions: A systematic review and meta-analysis. (
  • Cytomorphologic patterns of breast lesions in Sudanese patients: lessons learned from fine needle aspiration cytology. (
  • Unsuccessful preoperative biopsies, fine needle aspiration cytology or core needle biopsy, lead to increased costs in the diagnostic workup in breast cancer. (
  • A comparative analysis of core needle biopsy and fine-needle aspiration cytology in the evaluation of palpable and mammographically detected suspicious breast lesions. (
  • Clinical Application of Ultrasound-Guided Thyroid Fine Needle Aspiration Biopsy and Thinprep Cytology Test in Diagnosis of Thyroid Disease', Asian Pacific Journal of Cancer Prevention , 17(10), pp. 4689-4692. (
  • Wei, Y., Lu, Y., Li, C. Clinical Application of Ultrasound-Guided Thyroid Fine Needle Aspiration Biopsy and Thinprep Cytology Test in Diagnosis of Thyroid Disease. (
  • To study the clinical application value of ultrasound guided thyroid fine needle aspiration biopsy and thinprep cytology testing in diagnosis of thyroid disease. (
  • It is demonstrated that ultrasound-guided thyroid fine needle aspiration biopsy and thinprep cytology testing have diagnostic value in clinical application for thyroid disease,showing good diagnostic coincidence rates with histopathological examination. (
  • Clinical data, cytology and histopathology results were retrospectively analyzed on all patients who underwent thyroid FNA biopsy in our outpatient endocrinology clinic between January 1998 and April 2003. (
  • We prospectively recorded the clinical information and cytology results of all consecutive patients who underwent FNA biopsy of thyroid nodules in the outpatient endocrinology clinic of our hospital in a computerized database. (
  • Procedures to gather cells for cytology are often less invasive than other forms of biopsy , and therefore may cause less discomfort, be less likely to result in serious complications, and cost less to perform. (
  • Fine Needle Aspiration Cytology of Pulmonary Lesions: A Reliable Diagnostic Test" Pathology 33 (2001): 13-16. (
  • Fine-needle biopsy is used to sample diseased tissue for microscopic evaluation of cells (ie, cytology), which may be helpful in the initial or definitive diagnosis of infection, neoplasia, or other clinical states. (
  • Mir F, Alnajar H, Rohra P, Naumaan A, Cheng L, Gattuso P. Metastatic granular cell tumor to the breast diagnosed by fine needle aspiration cytology: A case report with review of the literature. (
  • Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and biopsy (FNB) has been widely accepted as a fundamental procedure for the diagnosis and staging of lesions of the gastrointestinal tract or non-gastrointestinal lesions within reach of the aspiration needle. (
  • This chapter focuses on common technical aspects of EUS-FNA and FNB, such as the choice of needle and use of the stylet and suction, and performs a short review of the current applications of EUS-guided FNA in gastrointestinal and extra-intestinal lesions, along with a brief review of the adverse events that have been associated with the procedure. (
  • The diagnostic accuracy of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided FNA of solid pancreatic lesions: a meta-analysis. (
  • Comparison of endoscopic ultrasound guided 22-gauge core needle with standard 25-gauage fine-needle aspiration for diagnosing solid pancreatic lesions. (
  • Optimal number of needle passes in endoscopic ultrasound-guided fine needle aspiration for pancreatic lesions. (
  • Fine needle biopsy helps to distinguish inflammatory, reactive, or cystic lesions from neoplasms as well as benign neoplastic lesions from malignant ones. (
  • However, a mass in the area of the carotid bifurcation may represent a carotid body tumor , and many clinicians are reluctant to biopsy these lesions. (
  • To determine whether the increasing use of percutaneous fine-needle biopsy of abdominal lesions is associated with an increase in serious complications, the author updated a literature search and evaluated a questionnaire (distributed among selected hospitals in the United States in 1986 and 1987) that followed up a questionnaire distributed in 1983. (
  • In some cases of uncertain lesions in the kidney it would be helpful to perform biopsies for preoperative histopathological evaluation. (
  • Core biopsy of renal lesions is accurate enough for histopathological evaluation and determination of therapeutic procedure. (
  • This document contains recommended procedures for performing fine needle aspiration biopsies of superficial (palpable) and deep-seated (nonpalpable) lesions/masses, from patient preparation through staining the smear. (
  • When properly used in well-indicated patients, fine needle aspiration biopsy of orbital lesions is an invaluable adjunct diagnostic technique. (
  • Solitary pleural amyloid nodules occurring as coin lesions diagnosed by fine-needle aspiration biopsy. (
  • METHODS: Seven or more passes were made with a fine needle into a variety of lesions during EUS-guided FNA. (
  • CONCLUSIONS: During EUS-guided FNA, at least 7 passes with a fine needle into pancreatic and miscellaneous lesions, and 5 passes into lymph nodes are needed to ensure a high degree of certainty for making a correct diagnosis. (
  • The Acquire Pulmonary EBUS-FNB Device is designed to be used with EBUS scopes for fine needle biopsy (FNB) of submucosal and extramural lesions of the tracheobronchial tree and the gastrointestinal tract. (
  • FNB of lung lesions may be performed during EBUS procedures when the tip design of a traditional Fine Needle Aspiration (FNA) needle is not optimal. (
  • An exclusive fine needle biopsy approach to sampling solid lesions under EUS guidance: a case controlled study. (
  • This atlas of fine needle aspirate preparations from benign and maligant liver lesions, both primary and metastatic processes, is a comprehensive guide to the indications for, and techniques and interpretations of, needle aspirations of the liver. (
  • Opening sections discuss pre-procedure evaluations as well as actual needle biopsy techniques, with the remainder of text devoted to 200 colour micrographs that provide illustrations of lesions that may currently be found by cytopathologists. (
  • Fine Needle Biopsy (FNB) is often done during EUS procedures of pancreatic and non-pancreatic lesions where the tip of the FNA needle is not optimal. (
  • Fine needle aspiration (FNA) biopsy has been rarely used in oral and oropharyngeal lesions. (
  • The goal of this study was to assess the value and accuracy of FNA biopsy in the diagnosis of oral and oropharyngeal lesions particularly in regards to discriminating benign from malignant tumors. (
  • Sixteen cases of FNA biopsies obtained of various intraoral and oropharyngeal masses or lesions performed at our institution during the eight-year period from 1998 to 2006 were retrospectively reviewed. (
  • Sixteen cases of intraoral lesions evaluated by FNA biopsies during the period of 1998-2006 were reviewed. (
  • FNA biopsy of intraoral and oropharyngeal masses is a valuable procedure for the initial evaluation of various lesions. (
  • It provides helpful information about these lesions and avoids hasty or unnecessary surgical biopsy. (
  • Furthermore, aspiration biopsy is an important tool in the diagnosis and management of these lesions, both neoplastic and non-neoplastic, and can be sometimes complemented by ancillary studies for more accurate interpretation. (
  • This is probably due to the superficial nature and small size of these lesions, the limited space for maneuvering the needle and difficulty in immobilizing the lesion to obtain adequate samples, rather than to interpretation or inherent limitations of the technique itself. (
  • In this study, we retrospectively reviewed 16 cases of intraoral and oropharyngeal lesions sampled by FNA biopsy with particular attention to the cytologic features of specific tumors, diagnostic accuracy and cytologic- histologic correlation. (
  • Sixteen cases of intraoral and pharyngeal masses and lesions that were sampled by FNA biopsies during the period of 1998-2006 were retrieved from the archives of the pathology department of the Detroit Medical Center, Detroit, Michigan. (
  • To determine the advantages and limitations of a combined stereotaxic fine-needle aspiration biopsy and needle-core biopsy in the diagnosis of 353 nonpalpable breast lesions with special attention given to the collection of follow-up data. (
  • 353 nonpalpable breast lesions underwent 'one pass' stereotaxic fine-needle aspiration (21 gauge needle) and needle-core biopsy (18 gauge needle) at our institution from January 1990 to October 1993. (
  • Following the combined needle biopsy technique procedure, surgery was recommended for 83 lesions. (
  • Close radiologic surveillance of high-risk cirrhotic patients has resulted in the increasing detection of smaller lesions with many subjected to biopsy for tissue characterization. (
  • CT guided FNAC and/or Biopsy of lung mass is an effective modality to diagnose lung cancer, especially in peripherally situated lesions. (
  • Accuracy of needle biopsy of breast lesions visible on ultrasound: audit of fine needle versus core needle biopsy in 3233 consecutive samplings with ascertained outcomes. (
  • Less information is available on how these tests perform for biopsy of ultrasound (US) visible breast lesions. (
  • Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: The Institut Curie's Experience. (
  • Accuracy of sonographically guided 14-gauge core-needle biopsy: results of 715 consecutive breast biopsies with at least two-year follow-up of benign lesions. (
  • This discussion will focus on fine-needle biopsy of solid peripheral tissues, such as peripheral lymph nodes and solid skin lesions. (
  • Fine needle biopsy (FNB) is a procedure in which a small-caliber needle is placed into a mass, cellular material is removed, and a cytologic diagnosis is rendered. (
  • In the less frequent occurrence of a non-definitive diagnosis, either repetition of the FNA or a surgical biopsy is usually recommended. (
  • A needle biopsy, also called a needle aspiration , involves removing some cells-in a less invasive procedure involving a hollow needle-from a suspicious area within the body and examining them under a microscope to determine a diagnosis. (
  • Available at: (
  • A review of the use of fine-needle aspiration biopsy of mammary tumors for diagnosis and research. (
  • BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the preferred modality for the cytological diagnosis of various cancers. (
  • Optimal number of EUS-guided fine needle passes needed to obtain a correct diagnosis. (
  • Fine-needle aspiration biopsy of the thyroid gland is safe, inexpensive, minimally invasive, and highly accurate in the diagnosis of nodular thyroid disease. (
  • Cost comparison between benign diagnosis with core-needle biopsy plus ultrasound stability for more than one year versus uncomplicated lobectomy. (
  • To determine the reliability of the core-needle biopsy findings, we compared the diagnosis from the core-needle specimen versus the histologic findings in the surgical specimens when core-needle biopsy findings indicated malignancy or follicular proliferation and versus the stability of the nodule on ultrasound follow-up for one year when core-biopsy findings indicated benignity. (
  • Core-needle biopsy yielded a diagnosis for 179 (91.7%) nodules, of which 122 (62.5%) were classified as benign, 50 (25.6%) as follicular proliferation, and 7 (3.6%) as malignant. (
  • We hypothesized that the increase in biopsies could significantly affect diagnosis of thyroid cancer, and possibly lead to overdiagnosis. (
  • The current study aims to identify an increase in the number of unnecessary thyroid fine-needle aspiration biopsies, and to determine whether it contributes to increasing diagnosis of thyroid cancer. (
  • This study was planned to compare the role of CT guided lung FNAC and Biopsy in diagnosis of Lung cancer. (
  • Conclusions: CT guided lung FNAC and Biopsy is a simple and safe method with high diagnostic accuracy for diagnosis of Lung cancer. (
  • Free-hand CT-guided tissue-core biopsy and aspiration appears to be a safe and very accurate procedure for use in the diagnosis of bone-associated diseases in small animals. (
  • The traditional diagnosis mode of breast mass is excisional biopsy, which gives a precise diagnosis but may yield a benign pathological result in most cases. (
  • We also confirm the high sensitivity and specificity of thyroid FNA biopsy in the diagnosis of thyroid cancer. (
  • Since this method is more accurate and is safer and simpler than the traditional wedge or core biopsy of suspected pancreatic or ampullary tumors, and since it may eliminate the need for laparotomy in selected cases, we consider it the preferred method for immediate diagnosis of these neoplasms. (
  • In some situations, however, where a piece of tissue is removed rather than individual cells, a different type of biopsy may be required to confirm the cytologic diagnosis. (
  • Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis. (
  • Fine needle biopsy makes it possible to achieve an accurate diagnosis without surgery. (
  • If the diagnosis is not clear, the doctor may recommend a different biopsy procedure. (
  • It can also be used if the tissue removed during a fine needle aspiration did not yield a definitive diagnosis. (
  • A surgical biopsy may be done if other biopsy procedures do not provide a definitive diagnosis. (
  • Fine needle biopsy is the most useful procedure indicated in the evaluation of neck masses. (
  • A thyroid fine needle aspiration biopsy is a procedure that removes a small sample of tissue from your thyroid gland. (
  • The procedure is less invasive than open and closed surgical biopsies. (
  • Thyroid fine needle aspiration biopsy is a very safe procedure, but it does carry some slight risks. (
  • Before the actual biopsy is performed the doctor will give you an opportunity to ask any questions or express any concerns you might have about the procedure. (
  • A biopsy is a procedure to remove and examine a sample of tissue from a lump or suspicious area of the body. (
  • A biopsy is a procedure to remove a tissue sample. (
  • A fine needle aspiration biopsy of a thyroid nodule is a simple and safe procedure performed in the doctor's office. (
  • During the procedure you may feel some neck pressure from the ultrasound probe and from the needle. (
  • Some neck discomfort at the site of the biopsy is expected following the procedure. (
  • The procedure is less invasive than surgical biopsy, leaves little to no scarring and does not involve exposure to ionizing radiation. (
  • If an HMO or community does not have practitioners with expertise in performing FNA, or there are not cytopathologists available to do the unique form of interpretation needed for FNA results, patients are likelier to have a core needle biopsy, as this procedure, while more invasive for patients, requires less skill to obtain a valid sample, and less skill for pathologists to read and interpret. (
  • The biopsy would also probably need him to have some pain meds for a little while, at least if he were a mammal that is standard procedure for any surgery. (
  • This procedure is called histology and requires the use of a thicker needle to obtain more sample. (
  • Fine needle aspiration (FNA) is a procedure used to obtain a sample of cells from a breast lump to determine whether it's a cyst , an infection, a benign tumor, or cancer. (
  • Having a fine needle aspiration may seem scary, but it's a safe, minor procedure that provides clear information about the nature of a lump. (
  • There's little you need to do to prepare for fine needle aspiration, but the following information may be helpful to know in advance of the procedure. (
  • Fine needle aspiration is an outpatient procedure performed in a healthcare provider's office or a medical clinic that has professionals trained in the technique and access to a pathology lab that can examine the fluid collected. (
  • Core biopsy is definitely a robust and reliable diagnostic modality, but carries disadvantages in terms of a longer turn-around due to the tissue processing time, and patient discomfort during the procedure. (
  • FNA is a percutaneous procedure, which means the needle is passed through the skin to get to the area to be sampled. (
  • A breast biopsy is a simple medical procedure in which a sample of breast tissue is removed and sent to a laboratory for testing. (
  • Although a breast biopsy is relatively simple and its risks are low, every surgical procedure carries a risk. (
  • During this procedure, your doctor uses a larger needle to collect several samples, each about the size of a grain of rice. (
  • During this procedure, the doctor inserts a very thin needle into the suspicious area of the breast. (
  • A fine needle aspiration biopsy is a quick, minimally invasive diagnostic procedure used to help figure out what that lump or bump (mass or nodule) is. (
  • Studies have shown that the diagnostic accuracy increases when the doctor performing the biopsy procedure is the same as the doctor analyzing the biopsy material. (
  • When you arrive at Dr. Nadelman's office for the biopsy, you will be shown to a procedure room where Dr. Nadelman will perform a focused history and physical exam. (
  • Also, as Dr. Nadelman has a microscope in the procedure room, she can determine if the biopsy sample is adequate for analysis or further testing. (
  • An FNA biopsy is quick, and a relatively simple procedure. (
  • It's a minimally invasive procedure that utilizes a thin needle to take a small sample of abnormal-looking tissue. (
  • Thyroid nodules with a hyperthyroid picture on TSH are rarely cancerous and most of the time, do not need a biopsy. (
  • He or she will examine your thyroid and will order a thyroid ultrasound to see if you have any nodules requiring a fine needle aspiration biopsy. (
  • Gharib H (1994) Fine-needle aspiration biopsy of thyroid nodules: advantages, limitations, and effect. (
  • The introduction of fine-needle aspiration has had a substantial effect on the management of patients with thyroid nodules. (
  • To determine the diagnostic performance of ultrasound-guided core-needle biopsy in thyroid nodules after two inconclusive fine-needle aspiration biopsies. (
  • American Association of Clinical Endocrinologists (AACE) recommends ultrasound (USG)-guided fine-needle aspiration (FNA), universally for all thyroid nodules that are ≥ 10 mm in diameter in euthyroid subjects [ 1 ]. (
  • How to select nodules for fine-needle aspiration biopsy in multinodular goitre. (
  • The doctor who did the analysis has high confidence that I do not have cancer and I have faith that I do not either, so I am not going to do another biopsy unless my yearly ultrasound indicates that the nodule has grown in size or if I have new nodules. (
  • SLUCare's Fine Needle Biopsy Clinic evaluates thyroid enlargement and nodules in children, adolescents and adults. (
  • Patients with thyroid nodules are examined using advanced ultrasound and fine needle biopsy of the thyroid . (
  • Benign - This accounts for up to 70% of biopsies when using the Bethesda System (one of the most common ways that cytopathologists classify nodule biopsy specimens). (
  • Old-school biopsies seem simplistic in comparison, with their verdicts of benign or malignant and their basic information on cell type and proliferative potential. (
  • Additionally, biopsy could be used for identifying benign renal lesion for observation. (
  • Limitations of fine-needle aspiration are related to the skill of the aspirator, the expertise of the cytologist, and the difficulty in distinguishing some benign cellular adenomas from their malignant counterparts. (
  • To measure the economic impact of avoiding lobectomies in patients with benign core-needle biopsy findings. (
  • Zurück zum Zitat Mikaszewski B, Markiet K, Smugała A, Stodulski D, Szurowska E, Stankiewicz C (2017) Diffusion- and perfusion-weighted magnetic resonance imaging-an alternative to fine needle biopsy or only an adjunct test in preoperative differential diagnostics of malignant and benign parotid tumors? (
  • Fine-needle biopsy of the thyroid mass was consistent with benign adenomatoid goiter. (
  • In this case, Drs. Cruz, Villamin, Ranjan, and Suntay perform a fine-needle aspiration biopsy and an excision biopsy followed by histological examination, which revealed a benign lesion. (
  • A breast biopsy can help determine if a lump in your breast is cancerous or benign, which means noncancerous. (
  • This article explains the most common diagnostic tests for thyroid cancer -fine needle aspiration biopsy, ultrasound, and blood tests. (
  • BACKGROUND AND OBJECTIVE: The additional diagnostic value of endoscopic ultrasound-fine needle aspiration (EUS-FNA) over lymph node (LN) echofeatures alone in evaluating lymphadenopathy is unknown. (
  • Note: a special test is available on FNA biopsy results, called the Afirma Thyroid Analysis , from Veracyte, that eliminates the majority of non-diagnostic, indeterminate, or inconclusive FNA results. (
  • To review the literature on the utility of fine-needle aspiration biopsy in the diagnostic management of nodular thyroid disease. (
  • Some prospective cohort studies (Kim et al and Dewit et al) have shown a significant improvement in diagnostic yield with FNB needles on nonpancreatic lesion and gastric subepithelial masses. (
  • As cytological aspirates from endoscopic-ultrasound-guided fine needle aspiration (EUS-FNA) has limited diagnostic sensitivity and are suboptimal for molecular profiling and morphological characterisation of certain neoplasms, a fine needle biopsy (FNB) with three-pronged (Franseen geometry) cutting edge has been developed to procure histology. (
  • Fine needle aspiration biopsy or FNA is a diagnostic test that involves the removal of all or part of a tissue sample for examination under a microscope by a pathologist. (
  • In underdeveloped countries this diagnostic tool has been left aside, because the fear of tumoral seeding in to the needle tract [3], the lack of technology for adequate specimen processing and accurate interpretation. (
  • Conclusion: This study shows that the 20-G FNB outperforms the 25-G FNA needle in terms of diagnostic agreement, independent of the background and experience of the pathologist. (
  • To investigate the diagnostic value of ultrasound-guided core needle biopsy (US-CNB) in suspected cases of lymph node metastasis from cutaneous melanoma. (
  • This study aimed to evaluate the diagnostic value of BRAFV600E mutation and DNA ploidy determination for Papillary Thyroid Micro-Carcinoma (PTMC) through fine-needle aspiration. (
  • Where available, we recommend universal application of ultrasound guidance for thyroid FNA biopsy as a standard component of this diagnostic technique. (
  • Any physician can perform a biopsy, but very few get diagnostic results. (
  • Fine needle aspiration (FNA) biopsy is frequently used and entails placing a very thin needle inside the mass and extracting cells for microscopic evaluation. (
  • Holding the lump with one hand, the doctor will precisely sample the lump with a thin needle held in a needle holder, which provides greater control. (
  • For the biopsy, your doctor will use a very thin needle to withdraw cells from the thyroid nodule. (
  • With FNA, a sample of the lump is obtained using a small, thin needle. (
  • In a fine-needle aspiration biopsy of the breast, your doctor inserts a thin needle into a lump and removes a sample of cells or fluid. (
  • Finding out whether a pancreatic mass is cancer usually involves biopsy-putting a thin needle into the pancreatic mass to obtain a tissue sample that can be examined under a microscope. (
  • In an FNA, a very fine, thin needle is inserted into your thyroid, to aspirate (or 'suction out') cells and/or fluid from your thyroid nodule or mass into the needle. (
  • During a fine-needle biopsy of the thyroid, your doctor uses a thin needle to remove a small sample of tissue from your thyroid gland. (
  • 0.9-millimetre-thin needle, using sonographic testing. (
  • During one of these tests, your doctor may place a thin needle or wire into the area of the lump so the surgeon can easily find it. (
  • A fine needle aspiration (FNA) biopsy, on the other hand, is performed with a very thin needle and a local anesthetic. (
  • Dr. Nadelman will insert a very thin needle through the skin into the area of abnormal tissue. (
  • This report describes two cases of this entity diagnosed by fine-needle aspiration biopsy in patients without systemic amyloid deposits. (
  • We can now sample your lump using only a thin small needle which will leave a mark no bigger than a needle stick from a blood test. (
  • If the lump is near the surface of your body and can easily be felt, the doctor will probably just feel it to guide the needle in. (
  • If the lump is deep within the body (such as in the abdomen) or is harder to feel, the doctor will use an ultrasound scan or sometimes a CT scan to see where the needle is going and guide it into the right place. (
  • A fine needle is put into the lump to take a sample of cells. (
  • For most people a needle biopsy will show whether the lump is a sarcoma. (
  • Your health care providers may refer you for a fine needle aspiration biopsy (FNA) if a lump is discovered in your breast. (
  • The FNA biopsy is used to assess the lump. (
  • Her rationale: an anesthetic needle creates a lump and swelling around the injection site that can interfere with the ability to get an accurate sample. (
  • You may be having the biopsy to find what is causing a lump or growth in your thyroid. (
  • This machine, which uses high-frequency sound waves to provide an ongoing image of the lump, enables the healthcare provider to guide the needle to exactly the right spot. (
  • Fine needle biopsy is also used to determine the nature of a lump, nodule, or when general swelling occurs in the area. (
  • The doctor may recommend a biopsy if the patient has an abnormal mammogram or a lump in the breast. (
  • If a mammogram, ultrasound or MRI reveals an area in the breast that looks suspicious, or if a lump is felt in the breast, or in a nearby lymph node, a biopsy may be recommended. (
  • If there is a palpable lump, a biopsy may be recommended. (
  • In a fine needle aspiration biopsy, the surgeon, pathologist, or radiologist uses a very fine needle and a syringe to withdraw, or aspirate, a few cells from a palpable lump. (
  • If the lump or suspicious area can be felt, the doctor can guide the needle to its target by touch. (
  • If a lump is palpable, which means it can be felt with the hand, the needle may be guided by palpating the mass. (
  • A breast biopsy is the best way to evaluate if a suspicious lump or portion of your breast is cancerous. (
  • A breast biopsy is typically performed to investigate a lump in the breast. (
  • Your doctor will usually order a biopsy if they become concerned about the results of a mammogram or breast ultrasound, or if a lump was found during a physical exam. (
  • During a fine needle biopsy, you'll lie on a table while your surgeon inserts a small needle and syringe into the lump and extracts a sample. (
  • Fluid from a breast lump can be removed with a needle. (
  • If you or your doctor has detected a suspicious lump, your doctor may ask you to have a fine needle aspiration biopsy to gather more information about it. (
  • Letter: Fatality after fine-needle aspiration biopsy of liver. (
  • Riska H , Friman C . Letter: Fatality after fine-needle aspiration biopsy of liver. (
  • Fine-Needle Aspiration Biopsy of the Rat Liver Edition by G. Zbinden and Publisher Pergamon. (
  • The vet is recommending either a liver biopsy or fine needle aspiration (both of which would require anesthesia) to discover the cause of a mass that's either on or near Z's liver. (
  • Has anybody had a similar experience, or had a gecko undergo either a liver biopsy or fine needle aspiration? (
  • We have several biopsy techniques to achieve a sample of liver tissue for analysis. (
  • Rohra P, Mir F, Lin DM, Furlan K, Javidiparsijani S, Lucero D, Gattuso P. Role of fine-needle aspiration in post liver transplant patients: A clinical/cytological review. (
  • This biopsy is used to evaluate organ or tumor tissue. (
  • This assay allows a very small number of tumor cells from a needle biopsy to be analyzed with great precision, such that the biopsy can be performed more safely with a smaller needle using a less aggressive technique," Dr. Harbour said. (
  • In this study we evaluated the accuracy of and the impact on tumor management of core biopsy for histopathological evaluation of small solid renal masses. (
  • After radical or partial nephrectomy 250 renal tumor biopsies were performed in 50 patients. (
  • In 49 of 50 cases (98%) we could define the malignant behavior of the tumor when performing 1 central and 4 peripheral biopsies of each tumor. (
  • In renal tumors 4 cm or smaller in diameter the accuracy of 1 central and 1 peripheral biopsy each regarding definition of tumor origin, tumor grading and cell type/growth pattern was 96% and 95.5%, 84% and 84.4%, and 87.5% and 89.5%, respectively. (
  • We present the cytologic findings observed in a fine needle aspiration biopsy specimen of a rare myxoid variant of leiomyosarcoma with epithelioid features and the tumor had metastasized to the abdominal wall. (
  • Conclusions: NGS assays demonstrated clinical utility in solid tumor specimens, including those taken by biopsy or FNA. (
  • Fine needle aspiration (FNA) is a type of biopsy in which tumor samples are taken through thin needles. (
  • Endoscopic ultrasound-guided fine needle aspiration is superior to lymph node echofeatures: a prospective evaluation of mediastinal and peri-intestinal lymphadenopathy. (
  • After thorough examination, fine needle aspiration from several accessible enlarged lymph node groups were taken and sent for cytopathological examination and later biopsy of the significantly enlarged lymph node from the same anatomical region was performed and was sent for histopathological examination. (
  • Fine needle biopsy of lymph node in the neck. (
  • Almost all biopsies of suspicious breast masses used to be open surgical biopsies. (
  • 1-3 Therefore, clinical trials evaluating personalised treatment in pancreatic cancer prefer tissue procurement via percutaneous or surgical biopsies over EUS-FNA. (
  • Complications of percutaneous abdominal fine-needle biopsy. (
  • Sing RF, Kefalides PT, Mette SA, Fallahnejad M. Chest wall metastasis after percutaneous fine-needle aspiration biopsy. (
  • Sahai AV, Paquin SC, Gariepy G. A prospective comparison of endoscopic ultrasound-guided fine needle aspiration results obtained in the same lesion, with and without the needle stylet. (
  • The more commonly used aspiration technique uses syringe-created negative pressure as well as the shearing effect of the needle to collect material from the biopsied lesion. (
  • In contrast, Zajdela et al described a technique in which only a bare fine needle without suction was used to obtain material from the target lesion. (
  • Advocates for the nonaspiration (Zajdela) technique believe that grasping the needle hub directly improves operator sensitivity in placing the needle tip within a small lesion. (
  • When we use ultrasound, we confirm it by visualizing the needle in the lesion on the screen. (
  • In the present study, 21 dogs and two cats underwent a free-hand CT-guided tissue-core biopsy (17 animals) or fine-needle aspiration (six animals) of a bone lesion. (
  • However, fine-needle capillary sampling may be used to reduce blood contamination when the lesion is suspected to be highly vascularized (eg, thyroid gland, hemangiosarcoma) or when the aspiration pressure results in ruptured cells (eg, cells of the thyroid gland and some lymphomas). (
  • Insert the needle into the lesion e.g. 21-23G needle and a 2-5ml syringe. (
  • Whilst maintaining the vacuum, redirect the tip of the needle along multiple planes within the lesion. (
  • Before withdrawing the needle from the lesion, release the plunger thereby nullifying the vacuum. (
  • Withdraw the needle and syringe from the lesion. (
  • If the negative pressure (vacuum) is not released before the needle is withdrawn from the lesion, cells will be sucked into the barrel and the syringe and will be very difficult to recover. (
  • In humans, free-hand computed tomography (CT)-guided biopsy is an accurate method to obtain a tissue sample. (
  • Formalin fixed paraffin embedded biopsies were evaluated by 1 pathologist. (
  • A pathologist examined the biopsy samples under a microscope to look for cancer cells. (
  • Your healthcare provider will use a very fine needle (much smaller than a blood draw needle) to draw out some fluid, which will be examined under a microscope by a pathologist. (
  • You will interact with the physician performing the fine needle aspiration, but not the pathologist who will examine the sample and, ultimately, deliver the results. (
  • A core needle biopsy may be used if the pathologist needs a larger tissue sample than what can be obtained with a fine needle aspiration. (
  • Not only does Dr. Nadelman have extensive experience in FNA biopsy techniques, she is also a board certified cytopathologist and pathologist. (
  • Higher failure rates were observed in specimens submitted for lung cancer panel and melanoma panel (3.1% and 3.7% vs 1.0% colorectal cancer panel), metastatic bone specimens (36% vs 2.6% nonbone specimens), referred specimens (5.0% vs 1.8% in-house specimens), and small biopsy and FNA specimens (5.8% and 3.1% vs 0.7% resection/excision specimens). (
  • Test feasibility was higher in in-house specimens than referred specimens (99.1% vs 96.9% in resection specimens, 94.4% vs 87.3% in small biopsy specimens, and 94.3% vs 58.8% in FNA specimens). (
  • In some cases, your healthcare provider might inject a local anesthetic to the area before inserting the needle. (
  • A local anesthetic is often used to numb the area prior to a core biopsy. (
  • A core needle biopsy requires a local anesthetic. (
  • Superficial fine needle aspirates of superficially palpable masses are performed by pathologists and radiologists at Children's Health℠ under imaging guidance. (
  • No absolute contraindications exist to performing fine needle biopsy of neck masses. (
  • Fine-needle biopsies guided by endoscopic ultrasound may be useful for evaluating pancreatic masses, particularly when other biopsy methods have had negative results and pancreatic cancer is still suspected. (
  • In a randomised trial of 46 patients with pancreatic masses, procurement of histological core tissue as evidenced by total tissue and tumour areas was significantly higher for 22G FNB than FNA needle. (
  • We conducted a randomised trial comparing tissue acquisition between the 22-gauge (G) Franseen biopsy (Acquire, Boston Scientific) and 22G standard bevel FNA (Expect, Boston Scientific) ( figure 1B ) needles in patients undergoing EUS-guided sampling of pancreatic masses. (
  • However, aspiration biopsy studies of the intraoral and oropharyngeal masses are few and limited [ 13 - 16 ]. (
  • Endoscopic ultrasound-guided sampling of solid pancreatic masses: the fine needle aspiration or fine needle biopsy dilemma. (
  • Fine needle aspiration (FNA) is currently the standard of care for sampling pancreatic solid masses by using endoscopic ultrasound (EUS). (
  • The most common method for evaluation of a suspicious thyroid nodule or mass is a technique known as fine needle aspiration biopsy, abbreviated as FNA. (
  • Surgical biopsy was usually recommended for highly suspicious radiologic patterns and/or needle biopsy reports classified as atypical or malignant. (
  • If the suspicious area cannot be felt, then a radiologist can use imaging techniques to biopsy the area. (
  • A surgical biopsy is also performed if the suspicious area is too deep or too shallow for a core needle biopsy. (
  • If any of the three indicate a high degree of concern for cancer, then an open biopsy is carried out. (
  • By using this combination method, the frequency of missed cancers can be brought to 1% or less, which is comparable to the miss rate when using open biopsy alone. (
  • furthermore a subsequent curative parotid surgery can be complicated by a previous open biopsy. (
  • Stereotactic core biopsy was developed as an alternative to surgical biopsy. (
  • In stereotactic needle biopsy, the exact location of the mass is mapped using mammograms taken from two angles. (
  • This is also known as image-guided stereotactic breast biopsy. (
  • During a stereotactic biopsy, you'll lie face down on a table with a hole in it. (
  • The aspiration may be done with a needle or with a needle that is attached to a syringe. (
  • Most biopsies are performed with a very fine needle and a syringe that is attached to it to aspirate some cells that will be stained and analyzed. (
  • Conjuctival incision at 4 mm from limbus followed by the insertion of a 23 gauge needle attached to a syringe using a connector tubbing. (
  • Fine-needle biopsy may be performed with a needle attached to a syringe (ie, fine-needle aspiration) or with only a needle (ie, fine-needle capillary sampling). (
  • With the other hand, insert the needle tip (bevel side up) into the tissue, then retract and release the syringe plunger. (
  • Detach the needle from the syringe, then retract the plunger to fill the syringe with air. (
  • Reattach the needle to the syringe. (
  • Attach the needle and syringe, and coat the needle and syringe hub with sterile 4% disodium EDTA, then remove the needle from the syringe. (
  • The tissue biopsy is carried out using a syringe with a max. (
  • Detach the needle from the syringe. (
  • This enables your healthcare provider to guide the needle to exactly the right spot. (
  • Your doctor may use images of the inside of your body to help guide the needle. (
  • The provider may use x-ray, ultrasound, or MRI pictures to help guide the needle to the correct place. (
  • Images may be taken to help guide the needle. (
  • Another benefit of ultrasound is that it helps doctors accurately guide the needle when they perform a fine needle aspiration biopsy. (
  • If it cannot be felt, ultrasound may be used to help guide the needle to the right location by watching it on a screen. (
  • In some cases, an ultrasound is used to guide the needle. (
  • Accuracy and inter-observer agreement of the Procore 25-gauge needle for endoscopic ultrasound-guided tissue core biopsy. (
  • Another option is a core needle biopsy which uses a larger bore needle that extracts a thin core of tissue. (
  • The accuracy of FNA and core biopsies is similar when carried out by specifically trained practitioners. (
  • Fine needle aspiration, fluid aspiration, and/or core biopsy. (
  • How Does FNA Differ From Needle Core Biopsy? (
  • In a needle core biopsy, a thicker, large needle is used to obtain a 'core' tissue sample for analysis, and the larger sample that can be recut for smaller samples that can be sent out for further analysis. (
  • The 22G Franseen design with a crown-shaped needle tip revealing the three symmetrical planes for histological core tissue acquisition (A). The standard bevel needle used at fine needle aspiration for procurement of cytological aspirates (B). (
  • There was no significant difference between the sensitivity and the specificity of one pass fine-needle aspiration biopsy (57% and 96% respectively) and needle-core biopsy (60% and 97% respectively), but noncontributive samples were not included in the false negative diagnoses and atypical samples were included in the true positive diagnoses. (
  • Cost comparison between ultrasound-guided core needle biopsy of the thyroid gland and uncomplicated lobectomy. (
  • Correlation between core-needle biopsy and surgery. (
  • To assess the complications of core-needle biopsy. (
  • To analyze the reliability of diagnoses obtained with core-needle biopsy. (
  • This retrospective study reviewed 195 core-needle biopsies in 178 patients. (
  • Patients with invasive breast cancer undergo axillary ultrasound ± ultrasound fine needle aspiration (US-FNA)/core biopsy for preoperative staging depending on the ultrasound appearance. (
  • Our aims were to evaluate the accuracy of preoperative US + US-FNA/core biopsy for detecting axillary metastatic disease. (
  • Of the total 21 false negative US biopsies from the 18 patients, 81% (17/21) were performed via FNA and 19% (4/21) via core biopsy. (
  • An increase in the use of core biopsies may yield greater accuracy in correctly identifying axillary nodal disease. (
  • With core needle biopsy (CNB), the doctor removes small, solid samples of tissue. (
  • A core needle biopsy is similar to a fine needle biopsy. (
  • During an MRI-guided core needle biopsy, you'll lie face down on a table with your breast in a depression on the table. (
  • A small incision is made, and a sample is taken with a core needle. (
  • There is also a small risk that the fine needle aspiration biopsy will not show for sure whether the nodule is cancerous. (
  • To determine if a thyroid nodule is cancerous, doctors use a fine needle aspiration biopsy (FNA). (
  • As the needle is thin, it might miss nearby cancerous cells. (
  • Fine Needle Aspiration Biopsy, when carried out by an experienced practitioner is virtually free of significant complications. (
  • The potential complications will depend on the location of the biopsy. (
  • In 138 patients, the biopsy was performed by an oculoplastic or orbital surgeon, and 10 minor complications were reported. (
  • Eleven out of the 14 remaining patients were seen by an oculoplastic or orbital surgeon in consultation for complications arising from a fine needle aspiration biopsy of the orbit performed by someone else. (
  • It is associated with a low rate of complications due to the small caliber of the needle used. (
  • Complications like haemorrhage limit the frequent performance of tissue‐needle biopsies (TB), and the cells of peripheral blood have to be used as surrogate markers instead. (
  • Complications from a biopsy are rare. (
  • Preoperative US correctly identified 60/120 (50%) patients with axillary metastatic disease, 42/60 (70%) had subsequent true positive US biopsies. (
  • A FNA (fine needle aspirate) will be much less invasive and a little less risky - basically Z will need just enough sedation to not wiggle while the vet pokes the mass with a regular sized needle through the skin - like one you would give an injection with. (
  • FNA is a less invasive option for patients than a surgical biopsy. (
  • A thyroid fine needle aspiration biopsy can take a sample from the nodule to test for cancer. (
  • Not everyone who has a thyroid nodule needs a fine needle aspiration biopsy. (
  • He or she will slowly advance the needle into the nodule itself, moving it back and forth several times. (
  • Typically, the biopsy is performed under ultrasound guidance to ensure accurate placement of the needle within the thyroid nodule. (
  • Your doctor will insert the needle through the skin and into the thyroid nodule. (
  • An ultrasound-guided fine needle aspiration biopsy uses sound waves to help locate a nodule or abnormality within the thyroid and remove a tissue sample for examination under a microscope. (
  • Thyroid biopsy is used to find the cause of a nodule in the thyroid gland. (
  • Ultrasound is used to guide accurate placement of the needle within the thyroid nodule. (
  • The physician inserts a fine gauge needle through the skin and advances it into the thyroid nodule. (
  • The radiologist will insert the needle through the skin under direct imaging guidance, advance it to the site of the thyroid nodule and aspirate samples of tissue. (
  • My doctor asked me to take an ultrasound guided biopsy due to the discovery of a nodule. (
  • Under conscious sedation or basic numbing medicine, a fine needle is inserted in your throat, directly into the nodule, which is located in the thyroid. (
  • Some mild pain may be experienced if the nodule is deeper inside the thyroid, and you will be asked to hold your breath, not move, and to not swallow for the brief time the needle is injected. (
  • It is uncommon for bleeding to occur into the biopsied nodule. (
  • Swelling of the nodule or pressure in the area of the biopsy is a symptom of bleeding and should be reported to the doctor. (
  • If there is suspicion of a thyroid carcinoma, it can be beneficial to carry out a fine-needle aspiration biopsy of a non-enhancing nodule. (
  • Bang JY, Hebert-Magee S, Varadarajulu S. Objective assessment of reasons for needle change during endoscopic ultrasound-guided fine-needle aspiration. (
  • Wani S. Basic techniques in endoscopic ultrasound-guided fine-needle aspiration: role of a stylet and suction. (
  • A comparative study of endoscopic ultrasound guided fine needle aspiration with and without a stylet. (
  • Does Onsite Cytotechnology Evaluation Improve the Accuracy of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy? (
  • Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has been integral in transforming endoscopic GI practice from just an imaging model to more of an interventional tool. (
  • The summary below is from the full report titled "Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy of Suspected Pancreatic Cancer. (
  • To see whether fine-needle biopsies of the pancreas guided by endoscopic ultrasound are effective at finding cancer in patients whose previous biopsies using other methods did not show cancer. (
  • All of the patients had previous negative results on biopsies that had used methods other than endoscopic ultrasound. (
  • Tissue Is the Issue: Is Endoscopic Ultrasonography with or without Fine-Needle Aspiration Biopsy in the Staging of Non-Small-Cell Lung Cancer an Advance? (
  • Image-guided, minimally invasive procedures such as fine needle aspiration of the thyroid are most often performed by a specially trained radiologist with experience in needle aspiration and ultrasound. (
  • Because of this limitation, biopsy results are looked at in combination with palpation (what the mass felt like) and any image study including mammogram and ultrasound. (
  • Results of the thyroid biopsy are given as one of six possible diagnoses, according to the Bethesda System for Reporting Thyroid Cytopathology. (
  • As with all forms of cancer, thyroid cancer is diagnosed from the results of a biopsy. (
  • Biopsy results showed cancer cells in 57 of the 102 patients. (
  • Of the remaining patients, 37 had negative biopsy results and 8 had inconclusive findings. (
  • Articles were reviewed to assess the results of fine-needle aspiration biopsy and its effect on thyroid management and cost of care. (
  • Our enthusiasm with the sensitivity of this double stereotaxic needle sampling has been tempered by the results of this reanalysis in the light of a mean theoretical follow-up of three years. (
  • The results highlight the need for a review of our biopsy criteria, which may result in a decrease in our biopsy threshold. (
  • The aim of this study was to compare the results of palpation-versus ultrasound-guided thyroid fine-needle aspiration (FNA) biopsies. (
  • As established guidelines differ on the utility of ultrasound guidance, we aimed to compare the results of palpation-guided and ultrasound-guided thyroid fine-needle aspiration biopsies in our clinical case series. (
  • A biopsy is done if the results of either a physical examination or imaging tests, such as a mammogram or ultrasound, show a concerning change in the breast. (
  • You'll usually get the results of your fine needle aspiration biopsy within just a few days. (
  • In some cases, the results may be less clear, and in this case, you may need to have a surgical biopsy to gather more information. (
  • Healthcare providers perform these procedures much less often than fine needle aspiration biopsy. (
  • Needle biopsies are typically done using local anesthesia, and these procedures have a slightly greater risk of bleeding associated with them, so they are more often done by a surgeon in outpatient or ambulatory surgical facilities. (
  • It usually causes little or no discomfort, since the needle is smaller than what's normally used in biopsy procedures. (
  • The cytologic features of fine needle aspiration biopsies from 30 well- and 16 poorly differentiated HCC were reviewed and the adjunctive role of serum α-fetoprotein (AFP), hepatitis B virus (HBV) markers and radiologic findings evaluated. (
  • Yan L, Jakate S, Reddy V, Gattuso P. Metastatic hepatocellular carcinoma diagnosed by fine needle aspiration: A clinical and cytologic study. (
  • They also believe that less bleeding occurs with the nonaspiration technique, an advantage in the biopsy of more vascular tissue such as the thyroid gland. (
  • After cleaning the area, your provider will insert the thin, fine needle into your thyroid gland. (
  • Roh JL (2006) Intrathyroid hemorrhage and acute upper airway obstruction after fine needle aspiration of the thyroid gland. (
  • The biopsy is done in a hospital, a clinic, or your doctor's office. (
  • Be sure to follow your doctor's instructions for care after the biopsy. (
  • An FNA biopsy can be performed in a doctor's office and in most cases, you can return to your normal activities soon afterwards. (
  • If ultrasound guidance is needed, the biopsy is usually done in a radiology department. (
  • Cells are removed through a small, hollow needle. (
  • In a fine needle biopsy (FNB), fluid and cells are removed with a thin, hollow needle. (
  • A thin, hollow needle will then be inserted through the skin to the site. (
  • In an FNA biopsy, a doctor inserts a thin, hollow needle into the thyroid tissues and removes a sample of cells. (
  • The hollow needle withdraws cores, or small cylinders, of tissue from the mass. (
  • The doctor inserts a larger, hollow needle into the breast. (
  • When the needle reaches the fluid or tissue, samples will be taken. (
  • New needles are used for additional samples. (
  • The biopsy samples may be used to make slides immediately and/or collected in a solution to wash excess blood. (
  • A physician used a fine needle to take one or more biopsy samples from the site identified by ultrasound. (
  • If you specifically require biopsy or needle aspirates samples rather than tissue obtained from surgery, we can help with sourcing them for you. (
  • There can be up to 5 needle passes to collect enough cell samples. (
  • Your surgeon will make a small incision and remove samples with a needle or a vacuum-powered probe. (
  • The samples from your biopsy will be sent to a laboratory. (
  • A prospective comparison of EUS-guided FNA using 25-gauge and 22-gauge needles. (
  • The needle used is a thin, fine-gauge needle that is smaller in diameter than the needle used in most blood draws (usually a 25 or 27 gauge 1.5 inch needle). (
  • Most ophthalmic surgeons have used available needles without customisation ranging in size from 22 gauge (G) to 30G, with the 25G needle being the most commonly used. (
  • The accuracy of 250 fine needle biopsies of renal tumors. (