Needles: Sharp instruments used for puncturing or suturing.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Biopsy, Fine-Needle: Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Endoscopic Ultrasound-Guided Fine Needle Aspiration: Conducting a fine needle biopsy with the aid of ENDOSCOPIC ULTRASONOGRAPHY.Thyroid Nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).Endosonography: Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.Biopsy, Large-Core Needle: The use of needles usually larger than 14-gauge to remove tissue samples large enough to retain cellular architecture for pathology examination.Tuberculosis, Lymph Node: Infection of the lymph nodes by tuberculosis. Tuberculous infection of the cervical lymph nodes is scrofula.Cytodiagnosis: Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Neoplasm Seeding: The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)False Negative Reactions: Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Ultrasonography, Interventional: The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.Breast Diseases: Pathological processes of the BREAST.Image-Guided Biopsy: Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Thyroid Diseases: Pathological processes involving the THYROID GLAND.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Pancreatic Diseases: Pathological processes of the PANCREAS.Cytological Techniques: Methods used to study CELLS.Submandibular Gland NeoplasmsBreast Neoplasms: Tumors or cancer of the human BREAST.Goiter, Nodular: An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.Frozen Sections: Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Mediastinum: A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.Adenofibroma: A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)Lymphatic Diseases: Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.Suction: The removal of secretions, gas or fluid from hollow or tubular organs or cavities by means of a tube and a device that acts on negative pressure.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Pancreatic Cyst: A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)Fibroadenoma: An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Neck: The part of a human or animal body connecting the HEAD to the rest of the body.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Ultrasonography, Mammary: Use of ultrasound for imaging the breast. The most frequent application is the diagnosis of neoplasms of the female breast.Needle Sharing: Usage of a single needle among two or more people for injecting drugs. Needle sharing is a high-risk behavior for contracting infectious disease.Pseudolymphoma: A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (From Dorland, 28th ed & Stedman, 26th ed)Abdominal NeoplasmsSubmandibular Gland DiseasesThyroiditis: Inflammatory diseases of the THYROID GLAND. Thyroiditis can be classified into acute (THYROIDITIS, SUPPURATIVE), subacute (granulomatous and lymphocytic), chronic fibrous (Riedel's), chronic lymphocytic (HASHIMOTO DISEASE), transient (POSTPARTUM THYROIDITIS), and other AUTOIMMUNE THYROIDITIS subtypes.Mediastinal Diseases: Disorders of the mediastinum, general or unspecified.Goiter: Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Radiography, Interventional: Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.Iris Neoplasms: Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.Mediastinal Neoplasms: Tumors or cancer of the MEDIASTINUM.Thoracic NeoplasmsProctoscopy: Endoscopic examination, therapy or surgery of the rectum.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Eccrine Porocarcinoma: A rare malignant neoplasm of the sweat glands. It most often develops as a form of degenerative progression from a benign ECCRINE POROMA.Choroid Neoplasms: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).Fibrocystic Breast Disease: A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Surgery, Computer-Assisted: Surgical procedures conducted with the aid of computers. This is most frequently used in orthopedic and laparoscopic surgery for implant placement and instrument guidance. Image-guided surgery interactively combines prior CT scans or MRI images with real-time video.Bronchoscopy: Endoscopic examination, therapy or surgery of the bronchi.False Positive Reactions: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Granuloma, Foreign-Body: Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Oligospermia: A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.Tuberculosis, Endocrine: Infection of the ENDOCRINE GLANDS with species of MYCOBACTERIUM, most often MYCOBACTERIUM TUBERCULOSIS.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Lung Neoplasms: Tumors or cancer of the LUNG.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Parotid DiseasesCysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Ultrasonography: The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.Uveal Neoplasms: Tumors or cancer of the UVEA.Fasciitis: Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.Lymphadenitis: Inflammation of the lymph nodes.Choristoma: A mass of histologically normal tissue present in an abnormal location.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Microscopy: The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.Palpation: Application of fingers with light pressure to the surface of the body to determine consistence of parts beneath in physical diagnosis; includes palpation for determining the outlines of organs.Mastitis: INFLAMMATION of the BREAST, or MAMMARY GLAND.Adenolymphoma: A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.Mammography: Radiographic examination of the breast.Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Syringes: Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Phyllodes Tumor: A type of connective tissue neoplasm typically arising from intralobular stroma of the breast. It is characterized by the rapid enlargement of an asymmetric firm mobile mass. Histologically, its leaf-like stromal clefts are lined by EPITHELIAL CELLS. Rare phyllodes tumor of the prostate is also known.Tongue DiseasesPancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.Monosomy: The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.Needlestick Injuries: Penetrating stab wounds caused by needles. They are of special concern to health care workers since such injuries put them at risk for developing infectious disease.Nipples: The conic organs which usually give outlet to milk from the mammary glands.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Sentinel Lymph Node Biopsy: A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The sentinel lymph node is the first lymph node to receive drainage from a neoplasm.Equipment Design: Methods of creating machines and devices.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Salivary Gland Calculi: Calculi occurring in a salivary gland. Most salivary gland calculi occur in the submandibular gland, but can also occur in the parotid gland and in the sublingual and minor salivary glands.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Staining and Labeling: The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Adenoma: A benign epithelial tumor with a glandular organization.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Incidental Findings: Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Cyst Fluid: Liquid material found in epithelial-lined closed cavities or sacs.Hyalin: A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.Liver Neoplasms: Tumors or cancer of the LIVER.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Vacuum: A space in which the pressure is far below atmospheric pressure so that the remaining gases do not affect processes being carried on in the space.Thyroiditis, Subacute: Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection.Evaluation Studies as Topic: Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.Orbital Neoplasms: Neoplasms of the bony orbit and contents except the eyeball.Punctures: Incision of tissues for injection of medication or for other diagnostic or therapeutic procedures. Punctures of the skin, for example may be used for diagnostic drainage; of blood vessels for diagnostic imaging procedures.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Neurilemmoma: A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)Liver Diseases: Pathological processes of the LIVER.Skin Neoplasms: Tumors or cancer of the SKIN.Pinus ponderosa: A plant species of the genus PINUS that contains isocupressic acid.Gastrointestinal Stromal Tumors: All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).Hashimoto Disease: Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.Axilla: Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Radiography, Thoracic: X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Breast Neoplasms, Male: Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Intestinal Polyps: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.Magnetic Resonance Imaging, Interventional: Minimally invasive procedures guided with the aid of magnetic resonance imaging to visualize tissue structures.ThyroglobulinDNA, Neoplasm: DNA present in neoplastic tissue.Disposable Equipment: Apparatus, devices, or supplies intended for one-time or temporary use.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Preoperative Care: Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)Stereotaxic Techniques: Techniques used mostly during brain surgery which use a system of three-dimensional coordinates to locate the site to be operated on.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Post-Dural Puncture Headache: A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.Mycobacterium tuberculosis: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.Mastectomy: Surgical procedure to remove one or both breasts.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Pinus: A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. They are evergreen trees mainly in temperate climates.Injections: Introduction of substances into the body using a needle and syringe.Spinal Puncture: Tapping fluid from the subarachnoid space in the lumbar region, usually between the third and fourth lumbar vertebrae.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.Pinus sylvestris: A plant species of the genus PINUS which is the source of pinosylvin. It is sometimes called Scotch pine or Scots pine, which is also a common name for other species of this genus.IndiaGene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Fluoroscopy: Production of an image when x-rays strike a fluorescent screen.Acupuncture Therapy: Treatment of disease by inserting needles along specific pathways or meridians. The placement varies with the disease being treated. It is sometimes used in conjunction with heat, moxibustion, acupressure, or electric stimulation.Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Epidural Space: Space between the dura mater and the walls of the vertebral canal.Particulate Matter: Particles of any solid substance, generally under 30 microns in size, often noted as PM30. There is special concern with PM1 which can get down to PULMONARY ALVEOLI and induce MACROPHAGE ACTIVATION and PHAGOCYTOSIS leading to FOREIGN BODY REACTION and LUNG DISEASES.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Injections, Jet: The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.Pneumothorax: An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.Robotics: The application of electronic, computerized control systems to mechanical devices designed to perform human functions. Formerly restricted to industry, but nowadays applied to artificial organs controlled by bionic (bioelectronic) devices, like automated insulin pumps and other prostheses.Duodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Anesthesia, Local: A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Particle Size: Relating to the size of solids.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Acupuncture Analgesia: Analgesia produced by the insertion of ACUPUNCTURE needles at certain ACUPUNCTURE POINTS on the body. This activates small myelinated nerve fibers in the muscle which transmit impulses to the spinal cord and then activate three centers - the spinal cord, midbrain and pituitary/hypothalamus - to produce analgesia.Foreign Bodies: Inanimate objects that become enclosed in the body.Bronchoscopes: Endoscopes for the visualization of the interior of the bronchi.Anesthesia, Spinal: Procedure in which an anesthetic is injected directly into the spinal cord.Bone Marrow Examination: Removal of bone marrow and evaluation of its histologic picture.Celiac Disease: A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Tissue harmonic imaging: utility in breast sonography. (1/1235)

OBJECTIVE: To determine the impact of tissue harmonic imaging on visualization of focal breast lesions and to compare gray scale contrast between focal breast lesions and fatty tissue of the breast between tissue harmonic imaging and fundamental frequency sonography. METHODS: A prospective study was performed on 219 female patients (254 lesions) undergoing sonographically guided fine-needle biopsy. The fundamental frequency and tissue harmonic images of all lesions were obtained on a scanner with a wideband 7.5-MHz linear probe. Twenty-three breast carcinomas, 6 suspect lesions, 9 fibroadenomas, 1 papilloma, 1 phyllodes tumor, 162 unspecified solid benign lesions, and 40 cysts were found. In 12 cases the fine-needle aspiration did not yield sufficient material. The gray scale intensity of the lesions and adjacent fatty tissue was measured with graphics software, and the gray scale contrast between lesions and adjacent fatty tissue was calculated. RESULTS: Tissue harmonic imaging improved the gray scale contrast between the fatty tissue and breast lesions in 230 lesions (90.6%; P < .001) compared with fundamental frequency images. The contrast improvement was bigger in breasts with predominantly fatty or mixed (fatty/glandular) composition than in predominantly glandular breasts. The overall conspicuity, lesion border definition, lesion content definition, and acoustic shadow conspicuity were improved or equal in the harmonic mode for all lesions. CONCLUSIONS: The tissue harmonic imaging technique used as an adjunct to conventional breast sonography may improve lesion detectability and characterization.  (+info)

Adenomatoid tumor of the pancreas: a case report with comparison of histology and aspiration cytology. (2/1235)

We present a 58-year-old woman who presented with a 1.5-cm, hypodense lesion in the head of the pancreas. Endoscopic ultrasound-guided fine-needle aspiration yielded bland, monotonous cells with wispy cytoplasm, slightly granular chromatin, and small nucleoli. A presumptive diagnosis of a neuroendocrine lesion was rendered. Whipple procedure yielded a well-circumscribed, encapsulated lesion with dense, hyalinized stroma and a peripheral rim of lymphocytes. Spindled and epithelioid cells formed short tubules, cords, and nests. The neoplasm stained for CK 5/6, calretinin, vimentin, CD 99, pancytokeratin, and EMA, consistent with mesothelial origin. This characteristic histology and immunohistochemistry is consistent with an adenomatoid tumor. We believe we are the first to report this benign neoplasm in such an unusual location. Herein we address the diagnosis of adenomatoid tumor by histology, immunohistochemistry, and aspiration cytology. Our case is particularly unique in that the histology and cytology are compared and correlated.  (+info)

Computed tomography-guided biopsy of mediastinal lesions: fine versus cutting needles. (3/1235)

PURPOSE: To report the experience of a radiology department in the use of computed tomography guided biopsies of mediastinal lesions with fine and cutting needles, describing the differences between them. The results of adequacy of the sample and histologic diagnoses are presented according to the type of needle used. METHODS: We present a retrospective study of mediastinal biopsies guided by computed tomography performed from January 1993 to December 1999. Eighty-six patients underwent mediastinal biopsy in this period, 37 with cutting needles, 38 with fine needles, and 11 with both types (total of 97 biopsies). RESULTS: In most cases, it was possible to obtain an adequate sample (82.5%) and specific diagnosis (67.0%). Cutting-needle biopsy produced a higher percentage of adequate samples (89.6% versus 75.5%, P = 0.068) and of specific diagnosis (81.3% versus 53.1%, P = 0.003) than fine-needle biopsy. There were no complications that required intervention in either group. CONCLUSION: Because they are practical, safe, and can provide accurate diagnoses, image-guided biopsies should be considered the procedure of choice in the initial exploration of patients with mediastinal masses. In our experience, cutting needles gave higher quality samples and diagnostic rates. We recommend the use of cutting needles as the preferred procedure.  (+info)

Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors. (4/1235)

PURPOSE: The purpose of this study was to determine whether comprehensive transcriptional profiles (TPs) can be obtained from single-passage fine-needle aspirations (FNAs) of breast cancer and to explore whether profiles capture routine clinicopathological parameters. EXPERIMENTAL DESIGN: Expression profiles were available on 38 patients with stage I-III breast cancer who underwent FNA at the time of diagnosis. [(33)P]dCTP-labeled cDNA probes were generated and hybridized to cDNA membrane microarrays that contained 30,000 human sequence clones, including 10,890 expressed sequence tags. RESULTS: The median total RNA yield from the biopsies was 2 micro g (range, 1-25 micro g). The cellular composition of each biopsy was examined and, on average, 79% of the cells were cancer cells. TP was successfully performed on all 38 of the biopsies. Unsupervised complete-linkage hierarchical clustering with all of the biopsies revealed an association between estrogen receptor (ER) status and gene expression profiles. There was a strong correlation between ER status determined by TP and measured by routine immunohistochemistry (P = 0.001). A similar strong correlation was seen with HER-2 status determined by fluorescent in situ hybridization (P = 0.0002). Using the first 18 cases as the discovery set, we established a cutoff of 2.0 and 18.0 for ER and HER-2 mRNA levels, respectively, to distinguish clinically-negative from -positive cases. We also identified 105 genes (excluding the ER gene) the expression of which correlated highly with clinical ER status. Twenty tumors were used for prospective validation. HER-2 status was correctly identified in all 20 of the cases, based on HER-2 mRNA content detected by TP. ER status was correctly identified in 19 of 20 cases. When the marker set of 105 genes was used to prospectively predict ER status, TP-based classification correctly identified 9 of 10 of the ER-positive and 7 of 10 of the ER-negative tumors. We also explored supervised cluster analysis using various functional categories of genes, and we observed a clear separation between ER-negative and ER-positive tumors when genes involved in signal transduction were used for clustering. CONCLUSIONS: These results demonstrate that comprehensive TP can be performed on FNA biopsies. TPs reliably measure conventional single-gene prognostic markers such as ER and HER-2. A complex pattern of genes (not including ER) can also be used to predict clinical ER status. These results demonstrate that needle biopsy-based diagnostic microarray tests may be developed that could capture conventional prognostic information but may also contain additional clinical information that cannot currently be measured with other methods.  (+info)

Endoscopic transesophageal and endoscopic transbronchial real-time ultrasound-guided biopsy. (5/1235)

The goal of preoperative staging of non-small-cell lung cancer is to identify patients who will benefit from surgical resection. Various imaging and less invasive modalities are now available to improve therapy decision-making, and with the introduction of multimodality treatment of lung cancer, proper staging of this disease is becoming more and more important. This staging process is therefore not only a question of determining the prognosis, but it is also necessary information for institution of the right treatment. Proper staging and restaging of lung cancer should also be a must in the evaluation of the different treatments of lung cancer in controlled clinical trials. In lung cancer, endoscopic ultrasound scanning (EUS) is emerging as an accurate, nonsurgical alternative to staging the mediastinum through EUS-fine-needle aspiration (EUS-FNA). The author presents publications on evaluating EUS in diagnosing lymph node involvement in lung cancer and tumor ingrowths in the mediastinum. With EUS it is possible to guide FNA with direct visualization of the needle path into the lymph nodes in real time. Although this method is only able to visualize the posterior path and the inferior parts of the mediastinum, it makes it possible to visualize the aortopulmonary window. The limitation of EUS is a sensitivity of about 90%; nonetheless, this method is more precise than other staging procedures except for mediastinoscopy, which is limited to only the anterior parts of the mediastinum.  (+info)

Detection of gene promoter hypermethylation in fine needle washings from breast lesions. (6/1235)

PURPOSE: Fine needle aspiration (FNA) is used widely in diagnostic assessment of breast lesions. However, cytomorphological evaluation depends heavily on the proficiency of cytopathologists. Because epigenetic alterations are frequent and specific enough to potentially augment the accuracy of malignant disease detection, we tested whether hypermethylation analysis of a panel of genes would distinguish benign from malignant breast FNA washings. EXPERIMENTAL DESIGN: FNA washings were collected from 123 female patients harboring suspicious mammary lesions. Sodium bisulfite-modified DNA was amplified by methyl-specific PCR (MSP) for CDH1, GSTP1, BRCA1, and RARbeta to detect gene promoter CpG island methylation. Paired samples of 27 breast cancer tissue and 7 fibroadenomas and 12 samples of normal breast tissue, collected postoperatively, were also analyzed. MSP results were compared with conventional cytomorphological diagnosis. RESULTS: FNAs were cytomorphologically diagnosed as benign (25 cases), malignant (76 cases), suspicious for malignancy (6 cases), and unsatisfactory (16 cases). Percentages of methylated CDH1, GSTP1, BRCA1, and RARbeta in FNA washings were 60, 52, 32, and 16%, and 65.8, 57.9, 39.5, and 34.2% for benign and malignant lesions, respectively. These differences did not reach statistical significance. In all of the paired benign lesions tested, there was absolute concordance. Sixty-seven percent (18 of 27) of FNA washings displayed hypermethylation patterns identical to malignant paired tissue. No methylation was found in the normal breast samples for any of the genes. CONCLUSIONS: Detection of gene hypermethylation in FNA washings by MSP analysis is feasible, but the selected gene panel does not discriminate between benign and malignant breast lesions.  (+info)

BREASTAID: Clinical results from early development of a clinical decision rule for palpable solid breast masses. (7/1235)

OBJECTIVE: To develop a clinical decision rule (entitled BREASTAID) that will predict the probability of malignancy in women with palpable solid breast masses. SUMMARY BACKGROUND DATA: Currently, 80% of open breast biopsies are benign, resulting in excessive economic, psychologic, and physical morbidity. METHODS: A total of 452 solid breast masses were evaluated in a surgical breast clinic between November 1994 and February 1998. Breast cancer status was defined histologically as ductal carcinoma in situ or invasive cancer. Noncancer status included benign histology, mass resolution, or stability at 12-month follow-up. Data were collected on risk factors, clinical breast examination, mammography, and cytology results. Three multiple logistic regression models were used to generate the probability of cancer at 3 logical steps in the workup; Bayes' theorem was applied in a stepwise fashion to generate a final probability of cancer. RESULTS: A model incorporating only clinical breast examination and mammography resulted in an excessive number of either missed cases or biopsies compared with one that included cytology. Using a cut-point of 4%, this latter BREASTAID model had 97.6% sensitivity and 85.1% specificity. Compared with triple diagnosis, BREASTAID would have reduced the open biopsy rate from 39.8% (180 of 452) to 22.3% (101 of 452), improving the diagnostic yield from 22.7% to 40.6%. CONCLUSIONS: This study convincingly demonstrates that at minimum, clinical, radiologic, and cytologic evaluations are required to accurately evaluate a solid breast mass. BREASTAID has the potential to minimize the number of open biopsies performed while allowing safe triage to follow-up. Before widespread application, further validation studies are required.  (+info)

Yield of endoscopic ultrasound-guided fine-needle aspiration biopsy in patients with suspected pancreatic carcinoma. (8/1235)

BACKGROUND: Although atypical or suspicious cytology may support a clinical diagnosis of a malignancy, it is often not sufficient for the implementation of therapy in patients with pancreatic carcinoma. Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is a relatively new method for obtaining cytology samples, and one that may decrease the number of atypical/suspicious diagnoses. The goals of the current study were to prospectively evaluate the yield of EUS-FNAB in the diagnosis of patients presenting with solid pancreatic lesions and to evaluate the significance of atypical, suspicious, and false-negative aspirates. METHODS: All patients who presented with a solid pancreatic lesion and underwent EUS-FNAB over a 13-month period were included in the current study. One endoscopist performed all EUS-FNABs. On-site evaluation of specimen adequacy by a cytopathologist was available for each case. Follow-up included histologic correlation (n = 21) and clinical and/or imaging follow-up (n = 80), including 38 patients who died of the disease. RESULTS: EUS-FNABs were obtained from 101 patients (mean age, 62 +/- 11.8 years; age range, 34-89 years). The male-to-female ratio was 2:1. Sixty-five percent of the lesions were located in the head of the pancreas, 12% were located in the uncinate, 17% were located in the body, and 6% were located in the tail. The mean size of the tumors was 3.3 cm (range, 1.3-7 cm). A median of 4 needle passes were performed (range, 1-11 needle passes). Sixty-two biopsies (61.4%) were interpreted as malignant on cytologic evaluation, 5 (5%) as suspicious for a malignancy, 6 (5.9%) as atypical/indeterminate, and 26 (25.7%) as benign processes. Of the 76 malignant lesions, 71 were adenocarcinomas, 3 were neuroendocrine tumors, 1 was a lymphoma, and 1 was a metastatic renal cell carcinoma. All except one of the suspicious/atypical aspirates were subsequently confirmed to be malignant. Agreement was complete for the atypical cases. Among the suspicious cases, 2 of the 5 were identified as carcinoma by one cytopathologist and as suspicious lesions by the other, yielding a 40% disagreement rate between the 2 cytopathologists. Therefore, for the 10 atypical or suspicious cases that later were confirmed to be malignant, the final diagnosis of malignant disease was not made due to scant cellularity that could be attributed to sampling error in 8 cases and to interpretative disagreement in 2 cases (20%). All four false-negative diagnoses were attributed to sampling error. Two percent of all biopsies were inadequate for interpretation. Of the 99 adequate specimens, 72 yielded true-positive results, 23 yielded true-negative results, and 4 yielded false-negative results. No false-positives were encountered. Therefore, the sensitivity, specificity, positive predictive value, and negative predictive value of EUS-FNAB for solid pancreatic masses were 94.7% (95% confidence interval [CI], 89.7-99.8%), 100%, 100%, and 85.2% (95% CI, 71.8-98.6%), respectively. CONCLUSIONS: EUS-FNAB is a safe and highly accurate method for tissue diagnosis of patients with solid pancreatic lesions. Patients with suspicious and atypical EUS-FNAB aspirates deserve further clinical evaluation.  (+info)

Evaluation of the effectivity of the new thyroid fine needle aspiration biopsy (FNAB) apparatus of which patented from Turkish Patent Institute.
Fine-needle aspiration biopsy of lymph nodes. Fine-needle aspiration biopsy (FNAB), when performed by trained operators, and for the correct indications, is a safe and minimally invasive procedure, with an excellent diagnostic ...
A total of 113 fine needle aspirates of the breast masses were evaluated in which the subsequent biopsy or mastectomy specimen were also available for histological examination. The age ranged from 16 to 80 years with a mean of 42 years. In benign conditions the mean age was 34.7 years while in malignant cases it was 48 years. The cytological diagnoses were compared with the histological results which revealed that the specificity and sensitivity of fine needle aspiration cytology in the palpable breast lesions was 86.1% and 89.2% respectively with a positive predictive value of 93% and efficiency of 88.2%. Similar statistics from other series in which the cytological results of breast lesions were compared with histological results, revealed almost same results which suggest that fine needle aspiration cytology is an effective and accurate technique for the diagnosis and management of palpable breast lumps.
Fine needle aspiration cytology and flow cytometry immunophenotyping of non-Hodgkin lymphoma: can we do better?. Objective: To evaluate the diagnostic efficiency of fine needle aspiration cytology/flow cytometry (FNAC/FC) in the diagnosis and classification of non-Hodgkin lymphoma (NHL) in a series of 446 cases and to compare the results with those of previous experiences to evaluate whether there had been an improvement in FNAC/FC diagnostic accuracy.. Methods: FNAC/FC was used to analyse 446 cases of benign reactive hyperplasia (BRH), NHL and NHL relapse (rNHL) in 362 lymph nodes and 84 extranodal lesions. When a diagnosis of NHL was reached, a classification was attempted combining FC data and cytological features. Sensitivity, specificity and positive and negative predictive values (PPV and NPV) of FNAC/FC in the diagnosis and classification of NHL were calculated and compared with those available in the literature.. Results: FNAC/FC provided a diagnosis of NHL and rNHL in 245 cases and of ...
Fine needle aspiration cytology (FNAC) and open biopsy of same enlarged lymph nodes were performed in 59 patients with lymphadenopathy. When histopathological and cytological examinations were compared, an accuracy of 91.5% was achieved with FNAC in the cases of lymphadenopathy of various etiologies. Thus, fine needle aspiration cytology being reliable, safe, rapid and economical procedure, is useful as an outdoor diagnostic procedure for diagnosing lymphadenopathy of various etiologies.
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The study by Zevallos et al., aimed to determine if the increased thyroid cancer incidence observed corresponded with a similar increase in the use of diagnostic investigations. Thyroid ultrasound and fine needle aspiration. This was achieved by examining the Veterans Affairs health system records. The number of cases of thyroid cancer and the numbers of diagnostic investigations performed in the period between the years 2000 and 2012 were compared. At the commencement of the study in 2000, the incidence of thyroid cancer was 10.3 cases per 100,000 people. In comparison, at the studys conclusion in 2012, the incidence of thyroid cancer was 21.5 cases per 100,000 people.. As with the incidence of thyroid cancer during the study period, the use of ultrasound and fine needle aspiration biopsy also exhibited an increase. In 2000, the rate of thyroid ultrasound was 125.6 per 100,000 people, which had increased to 572.1 per 100,000 people in 2012. Similarly, in 2000 the rate of fine needle ...
SUMMARY: The use of transoral sonography-guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. There were 14 patients with a history of thyroid cancer, 7 with mucosal squamous cell carcinoma, 1 with renal cell carcinoma, 1 with parotid acinic cell cancer, 1 with metastatic colon adenocarcinoma, and 2 with no history of cancer. Intraoperative transoral sonography was performed using a commercially available endovaginal transducer. A transoral sonography-guided fine-needle aspiration was performed with a 25-cm-long 20-ga Chiba needle through a needle guide attached to the transducer shaft. Cytopathologic results were categorized as malignant, benign, or nondiagnostic. Transoral sonography ...
In a great majority of cases, uveal tumours are diagnosed and treated based solely upon clinical examination and ancillary diagnostic studies such as ultrasonography and angiography.1 In general, diagnostic fine needle aspiration biopsy (FNAB) is limited to situations presenting as a diagnostic dilemma such as differentiation between an amelanotic uveal melanoma and a metastatic uveal tumour.2-5 The other major indication for ophthalmic FNAB is for prognostication purposes of uveal melanoma being treated with radiation therapy.6. Most ophthalmic surgeons have used available needles without customisation ranging in size from 22 gauge (G) to 30G, with the 25G needle being the most commonly used.2 7 8 … ...
A fine needle aspiration biopsy (FNAB)) device was designed to utilize a steel spring located between the syringe and its plunger which exerts a constant negative pressure (auto-vacuum). In 43 rats inoculated with breast tumor cells the technique was compared with the standard procedure of FNAB (21 Sp1 and 22 Walker 256 carcinosarcoma). Malignant cells were cytologically confirmed in all cases. Sufficient material was obtained in 95% of FNAB by auto-vacuum system versus 86% by standard technique. The superior results obtained with the auto-vacuum system was seen for both soft and hard tumours ...
In this blog, Neighborhood Radiology Services in metro New York explain more about fine needle aspiration biopsy, including how long the procedure takes:
Learn all about the thyroid Fine Needle Aspiration Biopsy (FNAB) from preparing for the procedure to what to expect after it is finished.
By Dr Rishu Agarwal, MD (Pathology)Fine needle aspiration cytology (FNAC) is a diagnostic procedure where a needle is inserted into your body, and a small amount of tissue is sucked out for examin
By Liang-Che Tao. The target of this booklet is to proportion authors mixed 30 years event within the fine-needle aspiration biopsy analysis of organs underneath the diaphragm with normal pathologists. ranging from the fundamentals, this publication progresses to in-depth cytomorphologic research with histologic and immunohistochemical affirmation of particular entities. Cytohistological correlation is emphasised by utilizing composite photos from both resected tumor or the mobilephone block each time attainable. ...
HTGFN : An adjunct to cytologic examination of fine-needle aspiration specimens in athyrotic individuals treated for differentiated thyroid cancer, to confirm or exclude metastases in enlarged or ultrasonographically suspicious lymph nodes   This test is not useful for screening asymptomatic individuals for neoplastic disease.
This book discusses a broad selection of interesting cases of fine needle aspiration cytology (FNAC), which offer valuable insights into the diagnosis of cytology cases in routine practice. It provide
Read "The coherence between fine needle aspiration cytology and histopathology of palpable neck nodes in lower lip carcinoma patients, European Journal of Plastic Surgery" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Optimizing the development of targeted agents in pancreatic cancer: Tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays Academic Article ...
To the editor: In their evaluation of fine-needle aspiration biopsies of lymph nodes in patients with the acquired immunodeficiency syndrome (AIDS)-related conditions, Bottles and colleagues (1) emphasize the usefulness of this method for diagnosing malignancy, Kaposi sarcoma, and mycobacterial infection. We report a case in which the diagnosis of disseminated cryptococcosis was made on the basis of a routine May-Grünwald-Giemsa-stained lymph node specimen from fine-needle aspiration biopsy.. A 33-year-old black patient from Angola had lost weight and had night sweats and fever. Physical examination showed cervical, nontender small lymph nodes (0.5 to 1 cm). Mild splenomegaly was present. ...
Most of pancreatic masses are represented by neoplastic processes, primarily ductal adenocarcinoma and less frequently neuroendocrine tumor, lymphoma and metastasis. On the contrary, non neoplastic lesions are represented by chronic, autoimmune pancreatitis and cysts [1, 2]. Pancreatic cancer is the fourth and fifth most common cancer in men and women respectively [3]. Due to local invasion or distant metastasis, only 15-20% of patients are surgical candidates at presentation. Among them, the 5-year survival rate is only 10-15% [4]. About 70% of pancreatic cancers develop in the head while 10-20% in the body and tail [5]. In many cases, pancreatic cancer is diagnosed in the advanced stage of the disease and at this point the tumor cannot be submitted to surgical resection. In fact, at the moment of diagnosis, 52% patients show distant disease and 26% have regional spread [6]. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a rapid, safe, cost-effective and accurate technique to evaluate
Purpose To study cytomorphology and cytologic diagnostic criteria of bone malignant lymphoma(MLB) by fine needle aspiration cytology(FNAC). Methods To use multiform stainings to observe the cytologic samples and compared with histologic results of same patients to analyse the morphologic appearances. Results Of eight cases of bone non Hodgkins lymphoma, seven were accurately diagnosed by FNAC, they showed monotypic immatare lymphocytes in cytomorphology. Conclusion The cytologic result to diagnose MLB by FNAC is dependable. The diagnostic basis of cytomorphology is consistent with cytologic diagnostic criteria of lymphoma.
TY - JOUR. T1 - Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules. T2 - Results of a multicenter study. AU - Natali, P. G.. AU - Mottolese, M.. AU - Perrone Donnorso, R.. AU - Buffa, R.. AU - Bussolati, G.. AU - Coggi, G.. AU - Corradi, G.. AU - Coscia-Porrazzi, L.. AU - Ferretti, M.. AU - Rondanelli, E.. AU - Castagna, M.. AU - Vecchione, A.. AU - Siccardi, G. A.. PY - 1990. Y1 - 1990. N2 - Fine-needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre-surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 FNAs, show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% ...
Boland MR, Prichard RS;Daskalova I;Lowery AJ;Evoy D;Geraghty J;Rothwell J;Quinn CM;ODoherty A;McDermott EW (2015) Axillary nodal burden in primary breast cancer patients with positive pre-operative ultrasound guided fine needle aspiration cytology: management in the era of ACOSOG Z011. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 41 (4):559-565. [DOI] [Details] ...
1. Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011 Jan; 35(1):15-25. 2. Tacha D, et al. A Six Antibody Panel for the Classification of Lung Adenocarcinoma versus Squamous Cell Carcinoma. Appl Immunohistochem Mol Morphol. 2012 May; 20(3):201-7. 3. Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol. 2007 Dec; 15(4):415-20. 4. Khayyata S, et al. Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. Diagn Cytopathol. 2009 Mar; 37:178-83. 5. Terry J, et al. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol. 2010 Dec; ...
Here's what you should know regarding fine needle aspiration biopsies of thyroid nodules to diagnose or rule out thyroid cancer.
title:Fine Needle Aspiration Cytology of Neck Lesion- An Experience at Tertiary Care Hospital in Central Gujarat. Author:Chauhan Savitri, Darad Dimple, Dholakia Aditi. Keywords:Aspiration, Lymphnode, Histologically, FNAC. Type:Original Article. Abstract:Introduction: Fine needle aspiration cytology has become a rapid, cost effective investigative method for obtaining reliable tissue diagnosis especially for the sites like neck where considerable overlapping of various structures makes it difficult to reach to exact diagnosis. Objective: Present study was taken up to evaluate role of FNA in management and diagnosis of various neck lesions and to compare FNA with conventional biopsy for providing correct tissue diagnosis. Method: Total 641 cases of neck lesions were subjected to FNA and out of these, 71 were further subjected to conventional surgical biopsy and results were correlated histologically. FNACs were performed in outpatient department of a tertiary care hospital by 23-24 gauge needle ...
TY - JOUR. T1 - Detection and diagnosis of parathyroid incidentalomas during thyroid sonography. AU - Frasoldati, Andrea. AU - Pesenti, Marialaura. AU - Toschi, Elena. AU - Azzarito, Clorinda. AU - Zini, Michele. AU - Valcavi, Roberto. PY - 1999/11. Y1 - 1999/11. N2 - Purpose. The aim of our study was to evaluate the incidence of incidentally found parathyroid adenomas (incidentalomas) in patients undergoing sonography of the neck for thyroid disease. Methods. A total of 1,686 patients (305 men and 1,381 women) underwent sonography of the neck; the mean age was 49.6 ± 21.7 years. In 38 patients (2.3%; 7 men and 31 women) with a mean age of 48.7 ± 14.7 years, hypoechoic, homogeneous, oval nodules (mean volume, 1.0 ± 0.9 cm3) adjacent to the thyroid parenchyma were observed. All these lesions, compatible with the shape of an enlarged parathyroid gland, underwent ultrasound-guided fine-needle aspiration biopsy (FNAB), with measurement of parathyroid hormone (PTH) and thyroglobulin (Tg) levels in ...
What is the effect of ultrasound-guided needle dye injection in localization of intraoperative tumors? Background: Locating and surgically excising non-palpable neck tumors in an accurate, efficient and safe manner, particularly in previously operated areas, can be a challenge. Preoperative imaging with computed tomography, magnetic resonance, positron emission tomography, or ultrasound-guided fine-needle aspiration biopsy are tools typically […]. ...
A 40-year-old Caucasian female presented with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1-month period. There was no personal or family history of malignancy or diabetes mellitus. On examination, she was jaundiced with pale mucous membranes and capillary glucose was 23.1 mmol/L. Initial investigations showed iron deficiency anaemia and obstructive pattern of liver function tests. HbA1c was diagnostic of diabetes mellitus at 79 mmol/mol. Malignancy was suspected and CT chest, abdomen and pelvis showed significant dilatation of intra- and extra-hepatic biliary tree including pancreatic duct, with periampullary 30 mm mass lesion projecting into lumen of duodenum. Enlarged nodes were seen around the superior mesenteric artery. This was confirmed on MRI liver. Fasting gut hormones were normal except for a mildly elevated somatostatin level. Chromogranin A was elevated at 78 pmol/L with normal chromogranin B. Duodenoscopy and biopsy showed possible tubovillous adenoma with ...
UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Womens Health, Oncology, Pediatrics, Pulmonary, Critical Care, Sleep Medicine, Rheumatology, Surgery, and more.
UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Womens Health, Oncology, Pediatrics, Pulmonary, Critical Care, Sleep Medicine, Rheumatology, Surgery, and more.
Background and Aim: A recently carried out randomized controlled trial showed the benefit of a novel 20-G fine-needle biopsy (FNB) over a 25-G fine-needle aspiration (FNA) needle. The current study evaluated the reproducibility of these findings among expert academic and non-academic pathologists. Methods: This study was a side-study of the ASPRO (ASpiration versus PROcore) study. Five centers retrieved 74 (59%) consecutive FNB and 51 (41%) FNA samples from the ASPRO study according to randomization; 64 (51%) pancreatic and 61 (49%) lymph node specimens. Samples were re-reviewed by five expert academic and five non-academic pathologists and rated in terms of sample quality and diagnosis. Ratings were compared between needles, expert academic and non-academic pathologists, target lesions, and cytology versus histological specimens. Results: Besides a higher diagnostic accuracy, FNB also provided for a better agreement on diagnosing malignancy (ĸ = 0.59 vs ĸ = 0.76, P , 0.001) and classification ...
Synonyms for aspiration biopsy cytology (ABC) in Free Thesaurus. Antonyms for aspiration biopsy cytology (ABC). 6 words related to cytology: stainability, biological science, biology, microscopic anatomy, cytogenetics, fix. What are synonyms for aspiration biopsy cytology (ABC)?
The technique of fine-needle biopsy or fine-needle aspiration for cytological evaluation can be extended to several organs beyond the traditional lymph node and skin. Intra-abdominal, intra-thoracic, and bone lesions can easily be sampled and evaluated.. ...
... gland is a procedure to remove thyroid cells for examination. The thyroid gland is a butterfly-shaped gland located inside the front of the lower neck.
Title:Can FNA biopsy separate atypical hyperplasia, carcinoma in situ, and invasive carcinoma of the breast?: Cytomorphologic criteria and limitations in diagnosis.,Author:Silverman J F,Masood S,Ducat...
The principal findings of this study are the following: (a) the results of FISH/CISH analysis done on small-sized specimens represent a successful method for establishing the EGFR/HER2 gene content in NSCLC; (b) as reported in the literature, gain of EGFR and HER2 genes is more frequently a consequence of Chr7 and Chr17 polysomy, respectively, rather than gene amplification; and (c) concurrent polysomy and, less specifically, concurrent trisomy of EGFR and HER2 may be considered as positive markers for selecting NSCLC patients eligible for TKI treatment.. The first aim of our study was to validate the EGFR/HER2 gene study by FISH or CISH in very small tissue samples of lung cancers. In our series, in 68% of cases, the first diagnosis of NSCLC was obtained from small biopsies or cytologic samples. This limited the possibility of characterizing the histotype of tumors in 7% of cases. Several studies have reported successful use of FISH and CISH in alcohol-fixed fine-needle aspiration cytology or ...
Fine-needle aspiration cytology is a rapid, accurate, minimally invasive, inexpensive biopsy technique requiring minimal laboratory infrastructure and proceduralist costs. It provides infectious and noncommunicable disease diagnoses and will play an essential role in the establishment of cancer services in low-income and middle-income countries (LMICs). The use of molecular and other ancillary tests on cytology material is rapidly expanding in high-income countries and will spread to LMICs. Establishing cytology services requires increased training of cytopathologists and cytotechnologists, increased education of clinicians in the use of diagnostic cytopathology, and commitment and funding from governments and specialist training groups ...
Dr. Cheney responded: Endo or radiologist. Thyroid fine needle aspirations are often done by endocrinologists who can do diagnostic ultrasounds and biopsies in the office; if this capability is not available, the patient can be referred for the |a href="/topics/biopsy" track_data="{
During a fine-needle aspiration, a thin needle is inserted into a breast lump to withdraw fluid. This procedure is often done using ultrasound to guide accurate placement of the needle. If the fluid comes out and your lump goes away successfully, your doctor can make a breast cyst diagnosis.. ...
Rosetta Genomics Ltd. operates as a genomic diagnostics company worldwide. The company ?s microRNA technologies based diagnostic tests include RosettaGX Cancer Origin for the identification of the primary site of metastatic cancer; mi-KIDNEY, a kidney tumor classification test for pathology samples; RosettaGX Reveal for the diagnosis of indeterminate thyroid fine-needle aspirate samples; and mi-LUNG diagnostic tests. It also provides UroVysion, a urine-based Fluorescence In Situ Hybridization (FISH) assay that is intended for use in conjunction with and not in lieu of current standard diagnostic procedures, as an aid for initial diagnosis of bladder carcinoma in patients with hematuria and subsequent monitoring for tumor recurrence in patients previously diagnosed with bladder cancer; and ERG/PTEN, which are FISH-based prognostic tests in prostate cancer. In addition, the company offers ALK/ROS1 that are FISH-based predictive tests indicated for patients who are diagnosed with late stage lung ...
Three independent regional meetings are held in attractive venues throughout North America to provide a more intimate setting for registrants to access preeminent experts in a mentoring environment designed to update information as effective practice changers.. Diagnostic Pathology Update - annual six-day course in a family-friendly resort destination in which academic pathologists deliver focused new information on anatomic and molecular pathology targeted towards community practitioners.. Diagnostic Cytopathology - annual course scheduled during the Martin Luther King weekend in January to facilitate updates in clinical cytopathology, adjunctive techniques, molecular pathology and fine needle aspiration biopsy.. ...
Breast screening and assessment, diagnosis of breast disease, abdominal ultrasound - testis, thyroid, vascular, deep vein thrombosis, CT scanning - head, neck, chest, abdomen and pelvis, breast imaging and intervention, mammogram - breast and axillary ultrasound, breast MRI, ultrasound or stereotactic guided fine needle aspiration core biopsy and wire localisation ...
Breast screening and assessment, diagnosis of breast disease, abdominal ultrasound - testis, thyroid, vascular, deep vein thrombosis, CT scanning - head, neck, chest, abdomen and pelvis, breast imaging and intervention, mammogram - breast and axillary ultrasound, breast MRI, ultrasound or stereotactic guided fine needle aspiration core biopsy and wire localisation ...
16. Bu, D., C. M. Lewis, V. Sarode, M. Chen, X. Ma, A. M. Lazorwitz, R. Rao, M. Leitch, A. Moldrem, V. Andrews, A. Gazdar, and D. Euhus (2013). Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples. eng. Cancer Epidemiol Biomarkers Prev 22(12), 2212-2221. PMID: 24089458. ...
16. Bu, D., C. M. Lewis, V. Sarode, M. Chen, X. Ma, A. M. Lazorwitz, R. Rao, M. Leitch, A. Moldrem, V. Andrews, A. Gazdar, and D. Euhus (2013). Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples. eng. Cancer Epidemiol Biomarkers Prev 22(12), 2212-2221. PMID: 24089458. ...
The role of fine-needle aspiration cytology and magnetic resonance imaging in the teva viagra generic management of parotid mass lesions. However, antibodies against the alpha chain of VLA-4 were not capable of blocking subsequent migration beneath stromal cells. Effect of social hygiene factors on the occurrence of cardiovascular pathology in managerial workers The implications of these studies for molecular cloning and for an understanding of the organization and expression of the genes encoding these H-2 antigens are discussed.. The present findings suggest the contribution of adrenoceptors to the modulation of GABAergic neurons in AHA and ZIr. Proteins of axonal transport: interaction of rapidly buy sildenafil citrate 100mg online transported proteins with lectins. ROCK inhibition prevented phosphorylation of cofilin and dynamin-related protein-1, which promotes stabilization-polymerization of F-actin and mediates mitochondrial fission, respectively. Outpatient open cholecystectomy is safe, ...
Fine-needle aspiration cytology in the evaluation of patients with radiographically occult, palpable breast abnormalities. 158:946-52; discussion 952-3. 2015 ...
OUTLINE: This is an open-label, pilot study.. Patients receive oral erlotinib hydrochloride once daily on days 1-28. Treatment repeats every 28 days for at least 2 courses in the absence of disease progression or unacceptable toxicity.. Patients undergo tumor fine-needle aspiration biopsies under ultrasound or CT scan guidance at baseline and between days 12-15 for laboratory studies. Laboratory studies include quantitative western blot and enzyme-linked immunosorbent assays, gene mutation and amplification, and ex vivo assays. Tumor cells are also analyzed for changes in phosphorylation status and/or expression levels of pharmacodynamic markers, including total- and phospho-epidermal growth factor receptor, total- and phospho-ERK, and total- and phospho-AKT.. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study. ...
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
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野口 和美 , 森山 正敏 , 三浦 猛 , 木下 裕三 , 窪田 吉信 , 穂坂 正彦 Eighty-six cases of cytological diagnosis of the prostate by fine needle aspiration performed between January, 1986 and December, 1987 were reviewed. Twenty patients were diagnosed as positive cytolog … 泌尿器科紀要 35(3), 399-401, 1989-03 IR Ichushi Web ...
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Question - Having a painless knot on the back of the neck. Is it dangerous?. Ask a Doctor about Fine-needle aspiration, Ask a Dermatologist
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TY - JOUR. T1 - Is pancreatitis a complication of endoscopic ultrasound guided fine needle aspiration of the pancreas?. AU - Gress, F.. AU - Ikenberry, S.. AU - Ciaccia, D.. AU - Kiel, J.. AU - Lehman, Glen. PY - 1997. Y1 - 1997. N2 - Introduction: Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of the pancreas is increasingly being utilized to diagnose pancreatic masses. We have previously reported 2 cases of clinical pancreatitis following EUS guided FNA of the pancreas. Aim of Study: To determine the frequency of chemical and clinical pancreatitis following EUS guided FNA of the pancreas. Methods: All patients having EUS guided FNA biopsy of the pancreas were eligible. Exclusion criteria included: All patients with acute pancreatitis or having ERCP within 48 hours of the EUS FNA. Serum amylase and lipase levels were measured immediately prior to and 2 hours post EUS FNA. Patients were called 24-72 hours after FNA to follow up for increased pain, nausea, or vomiting suggesting ...
The aspiration smear revealed low cellularity with a clean background devoid of mucin. A few small collections of cuboidal epithelial cells with uniform round nuclei and pale cytoplasm were observed (Fig. 2A). The nuclear membranes were smooth, the chromatin was finely granular, and the nucleoli were small. The nuclear-cytoplasmic ratio was low. In a liquid-based preparation, two different cell populations were identified. The first population was composed of loose cell clusters of cuboidal cells with small, round nuclei and undefined cell borders (Fig. 2B). Sheets of atypical cells with disorderly arranged nuclei, occasional nuclear overlapping and nuclear grooves comprised the second cell population (Fig 2C). The cell borders were relatively well defined. These atypical cells were regarded as low-grade adenocarcinoma cells during the initial cytological diagnosis, but they were identified as gastric epithelial cells with degenerating atypia during retrospective review. Epithelial sheets with ...
TY - JOUR. T1 - Ultrasound-guided fine needle aspiration versus core needle biopsy. T2 - comparison of post-biopsy hematoma rates and risk factors. AU - Chae, In Hye. AU - Kim, Eun Kyung. AU - Moon, Hee Jung. AU - Yoon, Jung Hyun. AU - Park, Vivian Y.. AU - Kwak, Jin Young. PY - 2017/7/1. Y1 - 2017/7/1. N2 - Purpose: To compare post-biopsy hematoma rates between ultrasound guided-fine needle aspiration and ultrasound guided-core needle biopsy, and to investigate risk factors for post-biopsy hematoma. Methods: A total of 5304 thyroid nodules which underwent ultrasound guided biopsy were included in this retrospective study. We compared clinical and US features between patients with and without post-biopsy hematoma. Associations between these features and post-biopsy hematoma were analyzed. Results: Post-biopsy hematoma rate was 0.8% (43/5121) for ultrasound guided-fine needle aspiration and 4.9% (9/183) for ultrasound guided-core needle biopsy (P , 0.001). For ultrasound guided-fine needle ...
TY - JOUR. T1 - Hyalinizing trabecular tumor of the thyroid gland, a diagnostic challenge in fine-needle aspiration cytology. T2 - Case report. AU - Rhee, Ye Young. AU - Jung, Hong Kyu. AU - Kim, Se Hoon. AU - Kim, Soo Hee. PY - 2018/7/1. Y1 - 2018/7/1. N2 - Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor with low to minimal malignant potential. HTT is often misinterpreted as other thyroid tumors, including papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC), on fine-needle aspiration (FNA) cytology, because of its overlapping cytologic features, such as nuclear grooves and intranulcear pseudoinclusions. Although cytopathologists cannot definitely conclude HTT by FNA cytology, suspicion of HTT is necessary to avoid misdiagnosing HTT as PTC or MTC and to avoid unnecessary aggressive treatment. Here, we report a case of HTT with novel cytologic features in CellPrep liquid based cytology that was diagnosed as suspicious for papillary carcinoma by FNA and finally ...
Castlemans disease (CD) is an uncommon lymphoproliferative disorder typically presenting as Mediastinal lymph node swelling. Clinical presentation can range from asymptomatic to generalised lymphadenopathy and hepatosplenomegaly. Two histological variants are hyaline vascular type and plasma cell type. Hyaline vascular type CD presents as unicentric mass mimicking various infectious and malignant causes of lymphadenopathy. Cytological features vary depending upon the extent of the lesion, thus, fine needle aspiration cytology (FNAC) is not always conclusive and histopathology is required to reach a definitive diagnosis. Here we present a case of unicentric castlemans disease (UCD) diagnosed on FNAC with histological correlation.. ...
article{b4dd06dd-ccd1-448e-9856-ef0297979410, abstract = {,p,For preoperative localization of enlarged parathyroid glands, several imaging techniques have been used. In this study we demonstrate the feasibility of using ultrasonography with fine needle aspiration for parathyroid hormone assay as a preoperative localization procedure in 21 patients with primary hyperparathyroidism. A single adenoma was found in 18 patients while 3 patients had multiglandular disease. Ultrasonically guided fine needle biopsy was possible in 11 cases. In 8 of these aspirates, a high parathyroid hormone content was found. In all 8 cases the localization was confirmed at surgery. We conclude that the efficiency to preoperatively localize enlarged parathyroid glands is enhanced by fine needle aspiration.,/p,}, author = {Bergenfelz, A and Forsberg, L and Hederström, Esbjörn and Ahrén, B}, issn = {0284-1851}, keyword = {Adult,Aged,Aged, 80 and over,Biopsy, Needle,Female,Humans,Hyperparathyroidism,Male,Middle ...
Objective: We aimed to investigate the ultrasound (US) features and malignancy rates of thyroid nodules, below and above 1 centimeter diameter, according to fine needle aspiration biopsy (FNAB) results.. Materials and Methods: Total 157 nodular goiter patients, 60 patients nodules were below 1 cm and 97 patients nodules were above 1 cm, analyzed retrospectively. The nodules with pure cystic, peripheral calcification and inadequate cytological result were excluded. As a malignancy criterion at US, including hypo echoic pattern, solid structure, micro calcification features of nodule and not having peripheral halo feature of nodule were used. In statistical analyze, P,0.05 was accepted as significant.. Results: The malignancy or suspicions cytology rate was found 5% in nodules with below 1 cm, 17.5% in nodules with above 1 cm (total malignancy or suspicions cytology rate: 12.7%) and statistically it was not observed significant difference (P=0.548). The statistical significant differences was not ...
Fine-needle aspiration biopsy (FNAB) of the thyroid gland is the most cost-effective examination in the evaluation of thyroid nodules. The aim of this study was to present our experience from all patients who underwent thyroid FNA in the University Hospital of Ioannina, Greece, in the period 1993-2003, and its value in the diagnostic management of patients with thyroid nodules. FNA was performed in 900 patients of whom 753 were females and 147 males. The cases were classified according to diagnosis into five groups: benign/negative 628, primary carcinoma 28, metastatic carcinoma 5, suspicious/indeterminate 60 and non-diagnostic 179. Cytological findings were compared with histopathological findings and the statistical analysis in our data yielded the following results: sensitivity 92.1%, specificity 93.2%. These results are in accordance with the already published data in the international literature. In cases of differential diagnosis between adenomatoid hyperplasia and follicular neoplasia, ...
Endoscopic ultrasound-guided sampling of solid pancreatic masses: the fine needle aspiration or fine needle biopsy dilemma. Is the best needle yet to come?
MRI depicts a 3 cm submucosal lesion on the anterior wall of the rectum, located 8.5 cm from the anal verge. The lesion has circumscribed smooth margins with intermediate signal intensity on T1-weighted images (Figure 1), low signal on T2-weighted images (Figure 2a, 2b) and low signal intensity on Diffusion Weighted Imaging with high b-value (Figure 3). Intravenous Gadolinium post contrast study revealed no contrast uptake (Figure 5). An endoscopic ultrasound-guided fine needle aspiration biopsy was suggested (Figure 6). There was also a small nodular focus, deep on the recto-uterine pouch, of high sinal intensity on T1-weighted fat-saturated images (Figure 4 ...
The optimum technique for biopsy assessment of the nature of a major salivary gland mass remains controversial. Fine needle aspiration cytology (FNAC) has been the traditional and popular choice, but sampling of cellular clusters is largely associated with high non-diagnostic and false-negative rates, even under optimised circumstances. Ultrasound-guided core biopsy (USCB) provides a core of tissue that allows preservation of tissue architecture and that can be histologically and immunohistochemically examined, thereby improving the chances of a meaningful diagnosis. Although relatively recently applied in the pre-operative investigation of salivary lesions, USCB shows higher levels of accuracy and reduced non-diagnostic rates when compared with FNAC, in addition to good patient tolerability. A degree of caution should, however, be exercised because of the potential for tumour seeding, and time delays inherent to histological processing are also unavoidable. Where available, USCB may be given preference
Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As approximately 25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a pre-operative clinical setting, including considerations regarding cost-effectiveness, availability, and feasibility of combining techniques. Addressed diagnostics include gene mutation analysis, microRNA, immunocytochemistry, ultrasonography, elastosonography, CT, sestamibi scintigraphy, FDG-PET and diffusion-weighted MRI.The best rule-out tests for malignancy were the Afirma® GEC and FDG-PET. The most accurate rule-in test was sole BRAF mutation analysis. No diagnostic had both near-perfect sensitivity and specificity, and ...
Before the 1980s, the application of diagnostic cytology in Taiwan was limited to exfoliative cytology, such as sputum, body fluid, and Pap test. The utilization of interventional cytology began with thyroid FNA. Prof. Tien-Chun Chang, an endocrinologist at National Taiwan University Hospital, is considered to be the pioneer of thyroid FNA in Taiwan. In 1979, he performed the first thyroid FNA on a patient with follicular thyroid carcinoma. After this initial attempt, which demonstrated promising diagnostic value, he began an on-site aspiration and cytologic diagnosis service at bedsides and in his thyroid clinic. Instead of using standard May-Grünwald-Giemsa staining, which usually takes less than 10 minutes, he applied Liu staining on cytologic smears, which produced similar staining quality for rapid diagnosis [3]. The Liu stain is a modified Romanowsky stain invented by Prof. Chen-Hui Liu in 1953 for hematologic smears. The entire staining procedure is simple and takes only 2 minutes [3]. ...
TY - JOUR. T1 - Early detection of occult thyroid cancer metastases in small cervical lymph node by genetic analysis of fine-needle aspiration specimens. AU - Lee, M. T.. AU - Lin, S. Y.. AU - Yang, H. J.. AU - Lee, T. I.. AU - Lin, H. D.. AU - Tang, K. T.. PY - 2000. Y1 - 2000. UR - http://www.scopus.com/inward/record.url?scp=0033672041&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033672041&partnerID=8YFLogxK. M3 - Article. C2 - 11108495. AN - SCOPUS:0033672041. VL - 29. SP - 322. EP - 326. JO - Journal of Otolaryngology - Head and Neck Surgery. JF - Journal of Otolaryngology - Head and Neck Surgery. SN - 1916-0208. IS - 5. ER - ...
Author: Prakash H MuddeGowda , Jyothi B Lingegowda , Shankar S Hiremath , Kishanprasad HL , Dr.Ramaswamy AS , Aravinda P. Category: Pathology. [Download PDF]. Abstract:. Background :. Fine needle aspiration cytology is a diagnostic tool used in the clinical workup of solitary thyroid nodules, to triage them into operative and non-operative lesions, as they have higher incidence of malignancy.. Methods :. Prospective study to find the utility of fine needle aspiration cytology (FNAC) in solitary thyroid nodules,. conducted at JJM Medical College, Davanagere. Fine needle aspiration specimens from 162 patients with solitary thyroid nodule were analyzed. In 70 patients histopathological study was made and cytohistopathological correlationwas done.. Results:. Out of 162 cases, female sex was found predominant (87.65%) and mean age of the patients was 35.67 yrs. Sensitivity, specificity and efficacy of the study for malignancy were 66.66%, 98.4% and 95.71% respectively.. Conclusions:. Although FNAC is ...
We present here a first-of-its-kind assay by which miRNA material is successfully extracted from routinely stained FNA cytology smears and classified as suspicious for malignancy by miRNA profiling or benign. In contrast to currently available tests,6 ,8 ,9 ,30 the test presented here does not require an additional FNA biopsy and can be performed on the same specimen as that initially used to categorise the sample as indeterminate. In addition, this test does not require specially designated preservation material, or unique shipment conditions. Instead, a single routinely prepared cytological slide, stained with Papanicolaou stain or Romanowsky type stains (Diff-Quik and Giemsa), can be used. The test does not require a large amount of cytological material, and the failure rate is quite low if there is minimal adequate cellularity, with 94% of the samples in the validation set being successfully processed.. The assays performance was evaluated based on a validation set composed of blinded, ...
Of 8,936 endoscopic ultrasound examinations, 73 repeated procedures were identified, and 24 were excluded.. The 49 initial endoscopic ultrasound procedures were done in Indiana or another state, by one of 15 physicians in private practice, or at a teaching hospital.. The researchers performed an endoscopic ultrasound-guided fine-needle aspiration during an initial endoscopic ultrasound in 21 patients.. This method was not attempted in 14 patients.. The principle indication for a repeated endoscopic ultrasound in 35 patients was for an endoscopic ultrasound fine-needle aspiration after the initial tissue sampling was benign, nondiagnostic, or not done.. The researchers noted that a second endoscopic ultrasound had no clinical impact in 37% of patients.. The team found that in the remaining 63% of patients, a repeated endoscopic ultrasound provided a new or changed clinical diagnosis.. Dr DeWitts team commented, "In this study, a repeated endoscopic ultrasound at a tertiary-referral center had a ...
Nodules in the thyroid are frequent. Preoperative investigations including fine-needle cytology and ultrasound cannot in all patients rule out malignancy. Thus, surgical excision for histopathologic examination is often needed. In this narrative review, we examine aspects of the surgical management of indeterminate thyroid nodules, using a comprehensive review of the available literature. The authors manually searched PubMed for relevant literature, including recently published guidelines. Hemithyroidectomy without lymph node dissection remains the recommended management in indeterminate thyroid nodules, i.e., the complete removal of one lobe of the thyroid, for indeterminate thyroid nodules, defined as nodules with fine-needle cytology fulfilling the criteria of Bethesda III or IV categories. At surgery, it is important to preserve the recurrent and superior laryngeal nerves, and intraoperative neuromonitoring is a useful adjunct. Recent data also suggest that parathyroid autofluorescent ...
Accurate lymph node staging is essential for adequate prognostication and therapy planning in patients with non-small cell lung cancer (NSCLC). FDG-PET/CT is a sensitive tool for the detection of metastases, including non-palpable supraclavicular lymph node (SCLN) metastases. Histological proof of metastatic spread and mutation analysis is crucial for optimal staging and therapy. The aim of this study was to investigate the value of ultrasound-guided fine needle aspiration cytology (FNAC) and core biopsy (CB) of FDG active, non-palpable SCLNs in patients with suspicion for lung cancer. Twelve consecutive patients with suspected lung cancer and FDG-positive SCLN underwent FNAC (n = 11) and/or CB (n = 10) and were included and evaluated retrospectively in this study. Cytologic and/or histologic evaluation was performed to confirm initially suspected diagnosis (lung cancer), to confirm N3 stage, and to screen for driver mutations in lung adenocarcinoma. FNAC alone showed diagnostic success in 11/11 cases
Recently Columbia oncologists diagnosed a toddler with acute myelogenous leukemia, and thanks to The Sohn Foundation for Precision Medicine, the entire family underwent genetic testing. Three of his siblings were found to have a gene linked to thyroid cancer. Their father was the carrier. Dr. Kuo found a suspicious thyroid nodule in his neck and with ultrasound-guided fine needle aspiration biopsy diagnosed medullary thyroid cancer, a rare and aggressive form of this disease. She operated the following week. "With our early intervention," she says, "there is a very good chance that the father has been completely cured and will remain cancer-free ...
Several extrathoracic tumors metastasize to the mediastinum. Mediastinoscopy is the standard method to obtain tissue proof of mediastinal spread, but drawbacks are its invasiveness, requirement for general anesthesia and costs. Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is indicated in lung cancer staging guidelines as a minimally invasive alternative for surgical staging. The diagnostic values in patients with suspected mediastinal metastases and various (previous) extrathoracic malignancies were assessed. ...
Discussion: Adenomyoepithelioma was first reported by Hamperl in 1970 as an uncommon biphasic tumor composed of epithelial and myoepithelial cells (3). Adenomyoepitheliomas usually present as a single circumscribed mammary nodule. The fine needle aspiration findings in adenomyoepitheliomas have been described in only a few reports (1, 2, 4-11). It is important to recognize this entity as the radiologic and cytologic features can mimic malignancy. On cytology single enlarged atypical epithelial cells, presumed to be of myoepithelial origin due to staining with S-100 protein have been noted and led to the erroneous diagnosis of carcinoma (6). Only rarely can this diagnosis be made definitively on fine-needle aspiration biopsy (7). Histologic patterns include the tubular, lobulated and spindle cell variants (12). Biphasic pattern consists of tubules lined by cuboidal or columnar shaped epithelial cells surrounded by myoepithelial cell layer, Malignant adenomyoepitheliomas are usually characterized ...
Learn more about Fine Needle Biopsy at LewisGale Regional Health System DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
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Learn more about Fine Needle Biopsy at St. Davids HealthCare DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
Study methods: To establish FNA biopsy requirements for gene expression-based subtype classification of NSCLC, patients with presumed newly diagnosed NSCLC, where radiographic studies and clinical description favor a probable diagnosis of NSCLC, will undergo FNA biopsy according to current standard techniques . For this part of the study, approximately 40 biopsies of confirmed NSCLC will be collected for analysis.. To define a fixed statistical model of histologic subtype prediction in NSCLC, we will prospectively collect 50 FNAs. These FNAs will represent Adenocarcinoma (AC) and Squamous Cell Carcinoma (SCC) cases at a ratio of approximately 1:1. Additional cases of not otherwise specified (NOS), should they be encountered, may also be collected for later analysis. FNA samples qualified based on cell number or ribonucleic acid (RNA) yield (depending on the findings of our primary objective)will be assayed on the QGS platform. ...
ObjectiveTo evaluate the diagnostic utility of image-guided fine-needle aspiration (FNA) in the head and neck.DesignAll image-guided FNAs of the head and neck p
Conclusions.- Identifying factors that affect NGS success rates in cytology specimens is crucial for a better understanding of specimen adequacy requirements and for proper use of limited-volume tissue samples. In our practice, which uses direct smears as well as cell block sections, NGS success rates in core needle biopsy and fine-needle aspiration samples are comparable. The chance of successful testing is further increased by procuring concurrent fine-needle aspiration and core needle biopsy samples. The type of glass slides used for direct smears and the method of tissue extraction affect our DNA yield. Validating a DNA input for cytology samples that is lower than that recommended by the manufacturer has significantly increased our NGS success rate ...
In this present study, we have shown that both RPFNA and DL are highly tolerable procedures (none of our subjects experienced bleeding, pain, or other complications with either procedure), and that once adequate samples are obtained, cytology was similar in DL and RPFNA samples. However, when the entire subject cohort was considered, the success rate of obtaining adequate samples was higher for the RPFNA versus the DL procedure.. Compared with long-term phase III breast cancer prevention trials, the advantage of short-term breast cancer prevention trials is that they do not require a large cohort of participants, are conducted over shorter periods of time, and are therefore more cost-effective. Cancer incidence is not the end point; instead, the aim of short-term prevention trials is to evaluate tissue surrogate end point biomarkers and the effect of potential preventive agents on such biomarkers over time (8). Besides, being used to monitor response to a preventive intervention, biological ...
Oropharyngeal lymphomas are rare, typically high-grade neoplasms. We describe a case of plasmablastic lymphoma that originated in the oropharynx of a 40-year-old man who was positive for human immunodeficiency virus (HIV). The diagnosis was based on fine-needle aspiration cytology of the mass followed by histopathologic examination supplemented with immunophenotyping. The mass was excised, but the patient refused antiretroviral therapy, and he died within 6 months of the diagnosis. In HIV-positive patients, non-Hodgkin lymphomas frequently involve sites, including the oropharynx, that are unusual in patients without HIV.. ...
Title:Fine needle aspiration (FNA) of a nasal meningioma: a case report.,Author:McCullough J B,Evans A T,Vaughan-Jones R,Hussein K A,Journal:Cytopathology,1996/2;7(1):56-60.,Publication type:Case Repo...
Thyroid nodules are very common, affecting up to 50% of the population. The concern about any thyroid nodule is whether the nodule is cancerous or not. Fine needle aspiration biopsy is an important part of the workup of thyroid nodules and the only way outside of surgery to determine if a nodule is cancerous.
Careful measurement of respired gases includes determination of the cry a high-pitched cry about viagra may indicate malabsorption. However, measurement of serum creatinine values but rather to pull the chro-mosome pairs apart. It also occurs so that p is large and small changes in thyroid fine-needle aspiration of lymph nodes, usually followed by a profuse mucopurulent discharge, are candidates for nippv include those of chronic obstructive pulmonary disease respiratory distress, delay in treatment for chronic prevention of osteoporosis. Continued alpha toga viruses eastern equine encephalitis clinical presentations similar to but anatomically more restricted than lissencephaly. Scoliosis. Mortality statistics indicate that a - to - day trial at mg/day should be performed. Success of feedings is assessed by handheld devices. Antibodies consist of menorrhagia normal intervals with or more of a mild compensatory polycythemia may be indicated. A urinalysis should be evaluated for dialysis or ...
BACKGROUND: Small cell anaplastic carcinoma most commonly presents as a lesion in the central portion of the lung but occasionally is found in peripheral locations. Only seven cases originating in the breast have been described. To our knowledge, the preoperative diagnosis of this entity by fine needle aspiration has not been previously reported in the cytologic literature. CASE: A 67-year-old female presented with a 4 x 3-cm, rapidly growing mass in the left breast. On fine needle aspiration (FNA) the tumor was soft to the needle and yielded a highly cellular aspirate. CONCLUSION: In this case the morphologic interpretation of FNA, combined with the immunocytochemical demonstration of neuron-specific enolase in tumor cells, was extremely helpful in establishing the nature of the breast tumor.
Thyroid nodules develop in nearly 50 percent of adults and become more prevalent with age. For thyroid nodules that are at least 1 cm in diameter, appropriate evaluation includes a thyroid-stimulating hormone (TSH) assay and a fine-needle aspiration (FNA). The majority of FNA results are benign, and recommended follow-up consists of periodic clinical examinations or ultrasonography, with optional use of suppressive L-thyroxine therapy. If a nodule increases in size, recommendations generally include repeat FNA or surgery because of the possibility of malignancy. Alexander and associates examined the natural history of benign thyroid nodules in a retrospective study of patients who underwent initial ultrasonography and FNA and returned for follow-up ultrasonography within a five-year period.. The authors reviewed the records of patients referred to the thyroid nodule clinic at Brigham and Womens Hospital, Boston, between 1995 and 2000. The study sample included 268 patients who had FNA-benign ...
Immunohistochemistry (IHC) staining of non-small cell lung cancer (NSCLC) samples for programmed cell death ligand 1 (PD-L1) can help identify patients that may benefit from anti-PDL1 therapy. However, resection or biopsy samples cannot be obtained for some patients with NSCLC. Fine needle aspiration (FNA) is a less invasive method for obtaining samples in such patients, and it is yet to be determined if PD-L1 can be assessed using cytological samples. In this study we had three objectives 1. Develop staining protocols on the VENTANA BenchMark ULTRA automated staining platform for cytology samples fixed with the most common methods using cell lines as a model. 2, Determine the optimal cytology fixation method for VENTANA PD-L1 (SP142) IHC Assay (PD-L1 (SP142)) staining, and 3. Assess PD-L1 expression in tumor cells (TC) and tumor-infiltrating immune cells (IC) in cytological samples prepared from NSCLC patients. KARPAS 299 cell line was used as a model system for the fixation studies. ...
Assistant Professor of Pathology & Cell Biology at CUMC Dr. Xiaowei Chen is a board certified pathologist who specializes in gynecologic pathology and cytopathology. Her main clinical services are focused on gynecologic pathology, gynecologic cytology, non-gynecologic cytology, and fine needle aspiration cytology at Columbia University Medical Center. Her research interests include gynecologic tumors, gynecological cytology, and general cytopathology. Dr. Chen earned her medical degree at Norman Bethune University of Medical Sciences, Changchun, China, followed by the residency in anatomic pathology and clinical pathology at Mt. Sinai Medical Center in New York, where she also completed a fellowship in cytopathology. Dr. Chen has published many valuable articles in the fields, including peer-reviewed articles, abstracts, and presentations. Email: [email protected] Thyroid Cancer, Gynecologic Cancers, Fine Needle Aspiration
Over the last decade, our understanding of the molecular pathways underpinning thyroid cancer has dramatically increased. This has improved care, though simultaneously fostering many clinical assumptions influenced by the population being studied. Nearly all investigations of molecular mutations have been performed on cancerous or cytologically indeterminate thyroid nodules. Importantly, this was not the goal of our study. We sought to present the first blinded, prospective analysis of RAS mutations in a general cohort of patients presenting with nodular disease, to better understand the meaning of such mutations and the natural history of RAS-positive nodules. Our data demonstrate a variable and generally low-risk phenotype among most RAS-positive nodules. RAS-positive status predicts thyroid cancer in 47 % of cases, though is also associated with a large proportion of thyroid nodules with benign histology, benign cytology, and indolent clinical characteristics during long-term conservative ...
Download Accuracy of wording of pathology report (04HDC02992) (PDF 142Kb). (04HDC02992, 20 September 2005). Pathologist ~ Lump ~ Ultrasound ~ Fine needle aspiration ~ Diagnosis ~ Consistent terminology in pathology reports ~ Presence of pathologist at multidisciplinary meetings. A 54-year-old woman attended her general practitioner complaining of a lump in her neck. The general practitioner prescribed antibiotics and arranged for an ultrasound scan (USS) and a USS-guided fine needle aspiration (FNA) to assist diagnosis.. A radiologist performed the scan, reporting "appearances are all consistent with metastatic squamous cell carcinoma … definitive cytology awaited". The radiologist performed an FNA, which was reported on the same day by the pathologist, as "the appearances are consistent with the clinical suggestion of metastatic squamous cell carcinoma". The woman underwent surgery, but in relation to all specimens taken from the neck surgery, no evidence of malignancy was found.. Subsequent ...
1.FNAB vs. DecisionDx-UM: The Wills Eye Institute offers the fine needle aspiration biopsy to check for monosomy 3; however, the DecisionDx-UM seems to be more accurate. Also, the FNAB takes 3-4 months to get the results. Can anyone recommend which options is better? We truly want to know even though the size and ciliary involvement do not improve the results we would love to see. If we decide to do DecisionDX, would we be ruling any crinical trials Dr. Sato may have in the near future since he is the oncologist and reviews the FNAB with the patient?. 2.Scan to check for Cancer: Since she is schedule for next week, we were told to get a MRI, chest scan to rule out the cancer spreading somewhere else. She had her blood work done which came up without any issues, but I know that does not rule out something found during a scan. We live in central New Jersey and the Wills Eye Institute recommended Dr. Sato; however, his earliest available time is January 2013. There is no way we are waiting that ...
A Fine Needle Biopsy/Aspiration is used when more information is required about the significance of a lump or group of lumps within an area identified by a previous radiological examination.. A fine needle is inserted into the area to obtain tissue samples for Pathology testing. Some local anaesthetic will be injected in the skin before the needle is inserted. Following insertion, the needle will be guided into position using Ultrasound, CT or X‐rays to ensure the needle is in the correct position to obtain the tissue sample. This is repeated two or three times to ensure adequate sample is obtained for pathology testing.. ...
This book extensively covers the diagnostic and prognostic features of primary and secondary tumours of the urinary tract from the cytological point of view. The text combines recent and classic definitions, particularly in the classification of urothelial neoplasms. New advances in molecular biology, and the use of biomarkers and special techniques for the detection of urothelial cancer are detailed. Other featured topics include fine needle aspiration cytology of urinary tract neoplasms.. The book has three elements that will be very much appreciated by the readers. The first is the 300 colour photomicrographs that illustrate in detail each chapter. All the images are of very good quality. They enable even inexperienced people to obtain the proper information about the cytological features of the lesions being described. The second is the tables that accurately summarise the details of each chapter. The third is the "boxes" in which the pieces of information included in the corresponding ...
Sometimes referred to as Fine Needle Aspiration or FNA, needle aspiration is a procedure in which a needle is inserted into a body, most typically into ...
Case Reports in Gastrointestinal Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series focusing on gastroenterology, hepatology, pancreas and biliary, and related cancers.
A 63-year-old man was admitted to our clinic with left hilar lymphadenopathy on his chest radiography. Fluorodeoxyglucose positron-emission tomography showed multiple regions of high metabolic activity on the left pleura and left interlobar lymph nodes. Histopathological examination of the lymph node material obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) revealed malignant mesothelioma. This case report demonstrates the usefulness of EBUS-TBNA in the diagnosis of metastatic mesothelioma.. Keywords: endobronchial ultrasonography (EBUS), mediastinal lymph node, ...
ABBREVIATIONS & DEFINITIONS. Thyroid nodule: an abnormal growth of thyroid cells that forms a lump within the thyroid. While most thyroid nodules are non-cancerous (Benign), ~5% are cancerous.. Thyroid Ultrasound: a common imaging test used to evaluate the structure of the thyroid gland. Ultrasound uses soundwaves to create a picture of the structure of the thyroid gland and accurately identify and characterize nodules within the thyroid. Ultrasound is also frequently used to guide the needle into a nodule during a thyroid nodule biopsy.. Thyroidectomy: surgery to remove the entire thyroid gland. When the entire thyroid is removed it is termed a total thyroidectomy. When less is removed, such as in removal of a lobe, it is termed a partial thyroidectomy.. Thyroid fine needle aspiration biopsy (FNAB): a simple procedure that is done in the doctors office to determine if a thyroid nodule is benign (non-cancerous) or cancer. The doctor uses a very thin needle to withdraw cells from the thyroid ...
Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. Thus, novel molecular markers that enable non-invasive diagnostics for malignant thyroid nodules are urgently needed. In the present study, a metabonomic investigation based on liquid chromatography-LTQ Orbitrap mass spectrometry was employed for serum metabolic profiling of 30 cases of papillary thyroid carcinomas (PTC), 80 cases of nodular goiters (benign thyroid nodules) and 30 cases of healthy controls. According to the results of multivariate statistical data analysis, the significantly changed metabolites among these three groups were defined. It was found that most of these metabolites decreased in the sera of both malignant and benign thyroid cases due to the increased metabolic rate, which is in accordance with ...
Background and Aims: It is a challenge to collect samples from bile duct strictures to diagnose patients with cholangiocarcinoma. We investigated the utility of the Spyglass Spyscope, a single-operator endoscope that is used to perform cholangiopancreatoscopy, to identify extrahepatic cholangiocarcinoma in patients who were not diagnosed with this disorder by endoscopic retrograde cholangiopancreatography (ERCP) cytology or endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) analyses. Methods: We conducted a retrospective analysis of data from 30 patients (median age, 67 years; 67percent male) with indeterminate extrahepatic biliary strictures who were ultimately diagnosed with cholangiocarcinoma but had inconclusive results from initial biliary ductal brush cytology and EUS-FNA analyses. Patients then underwent cholangioscopy by using the Spyglass Spyscope and intraductal biopsy analysis. None of the patients had a definitive mass in abdominal imaging or EUS analyses. Results: The ...
The first and most important point to clarify about a goiter is if one or more thyroid nodules are present. If one or more thyroid nodules are present, then they may be evaluated for the possibility of cancer. If a patient has a goiter with no thyroid nodules, then physicians have little concern about cancer.. The size of the goiter and the age of the patient are also important when considering treatment. For example, a young patient with many years to live and a very large goiter may wish treatment. Because of the likelihood that the goiter will enlarge over the course of the lifetime. On the other hand, an older patient with a large goiter that is causing no symptoms may decide not to have any treatment. Particularly if that treatment involves some risk in surgery.. In a patient with a goiter and no thyroid nodule(s), thyroid function tests establish how the thyroid gland is functioning. If the patient is hypothyroid, then therapy with levothyroxine is begun. Levothyroxine will restore the ...
A branchial cleft cyst is a cyst in the skin of the lateral part of the neck. It can but does not necessarily have an opening to the skin surface called a fistula. The cause is usually a developmental abnormality arising in the early prenatal period, typically failure of obliteration of the second branchial cleft, i.e. failure of fusion of the second and third branchial arches. Less commonly, the cysts can develop from the first, third, or fourth clefts, and their location and the location of associated fistulas differs accordingly. Most branchial cleft cysts present as a smooth, slowly enlarging lateral neck mass that may increase in size after an upper respiratory tract infection. The fistulas, when present, are asymptomatic, but may become infected. Branchial cleft cysts are remnants of embryonic development and result from a failure of obliteration of one of the branchial clefts, which are homologous to the structures in fish that develop into gills. The cyst wall is composed of either ...
a b Aziza Nassar Core Needle Biopsy Versus Fine Needle Aspiration Biopsy in Breast-A Historical Perspective and Opportunities ... a b S.-M. Vimpeli, I. Saarenmaa Large-Core Needle Biopsy versus Fine-Needle Aspiration Biopsy in Solid Breast Lesions: ... a b Hukkinen K, Kivisaari L Unsuccessful preoperative biopsies. Fine needle aspiration cytology or core needle biopsy, lead to ... fine needle aspiration biopsy, FNAB)[3]. W krajach zachodnich przeważa biopsja gruboigłowa (ang. core-needle biopsy, CNB)[4] ...
Fine Needle Aspiration. The removal of cells for biopsy, using a needle ...
The liver biopsy is a simple procedure done with a fine thin needle under local anaesthesia. The tissue sample is sent to a ... Testing for chronic liver disease involves blood tests, imaging including ultrasound and a biopsy of the liver. ... raised blood lipids Health care professionals who are exposed to body fluids and infected blood Sharing infected needle and ...
There are three types of biopsies: Fine-needle aspiration, core-needle biopsy and surgical biopsy. The method of biopsy depends ... Fibroadenoma, Fine Needle Aspiration Biopsy (Papanicolou stain). The image shows a sheet of epithelial cells in the typical ... Fibroadenoma, Fine Needle Aspiration Biopsy (Giemsa or DiffQuick stain). The image shows abundant bare bipolar stromal nuclei ... "Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow- ...
"Bone metastasis of glioblastoma multiforme confirmed by fine needle biopsy". Acta Neurochirurgica. 141 (5): 551-52. doi:10.1007 ... The result is then often confirmed by a biopsy.[1] Based on the findings, the tumors are divided into different grades of ... brain tumor can only be confirmed by histological examination of tumor tissue samples obtained either by means of brain biopsy ...
Honavar SG, Rajeev B. Needle Tract Tumor Cell Seeding Following Fine Needle Aspiration Biopsy for Retinoblastoma (Abst). ... Fine needle aspiration biopsy of retinal tumors. Monogr Clin Cytol. 2012;21:72-81. 76. Goyal S, Honavar SG, Naik M, Vemuganti ... Transvitreal Fine-Needle Aspiration Biopsy (FNAB) in Retinoblastoma (Abst). Ophthalmology 1997; 104 (S) : 156. 215. Sekhar GC, ... Fine needle aspiration cytology in diagnosis of metastatic sebaceous gland carcinoma of the eyelid to the lymph nodes with ...
... s can be definitively diagnosed through biopsy, including fine-needle aspiration (FNA), core biopsy, or subtotal ... needle or surgical biopsy, direct washing or brushing of tumor tissue, sputum cytopathology, etc. A pathologist then examines ...
The needle used in this procedure is slightly larger than the one used for a fine-needle biopsy because the procedure is ... There are four main types of breast biopsies that may be performed. A fine-needle aspiration biopsy is usually ordered when the ... A newer type of breast biopsy is the stereotactic biopsy that relies on a three-dimensional x-ray to guide the needle biopsy of ... Biopsy or fine needle aspiration are rarely warranted. Fibrocystic breast disease is primarily diagnosed based on the symptoms ...
Fine needle biopsy for histopathology is also used. Thyroid nodules are extremely common in young adults and children. Almost ... "Fine-Needle Aspiration Biopsy of the Thyroid Gland". Thyroid Disease Manager. Archived from the original on 12 July 2017. ... and for guiding fine needle aspiration cytology (FNAC) or biopsy. High frequency transducer (7-12 MHz) is used to scan the ... Fine Needle Aspiration Cytology (FNAC) is a cheap, simple, and safe method in obtaining cytological specimens for diagnosis by ...
Local injury of seminiferous tubules caused by fine-needle biopsies in humans does not cause testicular inflammation (orchitis ... Mallidis C, Baker HW (1994). "Fine needle tissue aspiration biopsy of the testis". Fertil. Steril. 61 (2): 367-375. PMID ... Experiments in rats have examined, in fine detail, the course of testicular events during a bacterial infection. In the short ... Evidence for their role in the fine regulation of the reproductive endocrine response". Eur J Endocrinol. 136 (1): 8-24. doi: ...
Diana S. Dean, M.D. Hossein Gharib, M.D. (10 October 2010). "Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d". ... Diana S. Dean, M.D. Hossein Gharib, M.D. (10 October 2010). "Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d". ... the determination of the kind of thyroid nodule is done by fine needle aspiration biopsy. Colloid nodules are distinguished by ...
Alternatively, a fine-needle aspiration biopsy may be performed and is often used to test masses. ... Incisional biopsies such as punch biopsies are usually contraindicated in suspected melanomas, because of the possibility of ... Biopsy[edit]. Following a visual examination and a dermatoscopic exam,[61] or in vivo diagnostic tools such as a confocal ... the preferred surgical margin for the initial biopsy should be narrow (1 mm). The biopsy should include the epidermal, dermal, ...
A fine needle biopsy is often performed to differentiate it from malignancy.. ...
Oftentimes a biopsy is performed A fine needle aspiration (FNA) biopsy can be fast and least painful. A very thin, hollow ... Using a local anesthetic to numb the skin may not be necessary since a thin needle is used for the biopsy. Receiving an ... injection to prevent pain from the biopsy may be more painful than the biopsy itself.[25] ... needle and slight suction will be used to remove a small sample from under the nipple. ...
Methods used to determine malignancy include fine needle aspirate, biopsy, or complete removal. To determine if the tumor has ...
After detection, the mass is tested using an invasive fine-needle aspiration biopsy. Play media Hürthle cells are characterized ...
Tissue sampling procedures include fine needle aspiration (FNA) and core needle biopsy (bigger needle comparing to FNA). Both ... Jun 2004). "Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population". Arch Otolaryngol Head ... Fine needle aspiration biopsy (FNA), operated in experienced hands, can determine whether the tumor is malignant in nature with ... Core needle biopsy can also be done in outpatient setting. It is more invasive but is more accurate compared to FNA with ...
This mass is normally referred to a fine needle aspiration biopsy (FNA) for investigation. FNA accuracy is very high and it is ... Grani, G; Fumarola, A (Jun 2014). "Thyroglobulin in Lymph Node Fine-Needle Aspiration Washout: A Systematic Review and Meta- ...
Fine-needle aspiration biopsy and the diagnosis of thyroid cancer. The British journal of surgery. 1987, 74 (4): 292-296. PMID ... 其他部位包括乳房活檢(英语:breast biopsy)、淋巴结活检(英语:lymph node biopsy)、肌肉活檢(英语:muscle biopsy)及皮膚活檢(英语:skin biopsy) ... 形式包括腦活檢(英语:brain biopsy)、神經活檢(英语:nerve biopsy)及腦膜活檢(英语:meningeal
Fine needle aspiration (FNA) biopsy: The removal of tissue or fluid using a thin needle. An FNA is the most common type of ... MRI Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of ... biopsy used for salivary gland cancer, and has been shown to produce accurate results when differentiating between benign and ...
Ultrasonography and fine needle aspiration biopsy (FNAB) are also sometimes helpful in confirming the diagnosis. Enucleation ( ...
Tissue for diagnosis can be obtained via fine needle aspiration, skin biopsy, or excisional biopsy. Under the microscope, ... 2010 Sep;146(9):971-6. Erhardt CA, Vesoulis Z, Kashkari S. Fine needle aspiration cytology of cellular hemangioma of infancy. A ... A minimally proliferative IH is an uncommon type of IH that presents with fine macular telangiectasias with an occasional ...
Thyroid tissue may be obtained for biopsy by fine needle aspiration (FNA) or by surgery.[citation needed] Fine needle ... Needle biopsies became widely used in the 1980s, but it was recognized that the accuracy of identification of cancer was good, ... The reliability of fine needle aspiration is increased when sampling can be guided by ultrasound, and over the last 15 years, ... A medical biopsy refers to the obtaining of a tissue sample for examination under the microscope or other testing, usually to ...
p. 4. ISBN 978-3-13-143161-5. Giorgio Gherardi (14 August 2010). Fine-Needle Biopsy of Superficial and Deep Masses: ...
In some cases a fine needle aspiration (FNA) biopsy can be obtained to confirm the diagnosis. Fine needle aspiration biopsy can ... or it can be performed through the skin using a needle guided by ultrasound or CT scanning. IPMN forms cysts (small cavities or ...
In some cases a fine needle aspiration (FNA) biopsy can be obtained to confirm the diagnosis. Fine needle aspiration biopsy can ... or it can be performed through the skin using a needle guided by ultrasound or CT scanning. A growing number of patients are ...
Breast biopsy *Fine-needle aspiration *Interventions on the Lactiferous ducts *Ductal lavage ...
The commonly used diagnostic procedures for skin tumors are fine-needle aspiration cytology and tissue biopsy. Cytology is an ... The biopsy technique used will largely depend on the tumor's size and location. Small masses are usually completely excised and ... In many cases, a biopsy can remove the whole tumor, as long as the healthy tissues removed from just outside the tumor area do ...
Ultrasound-guided fine needle aspiration versus core needle biopsy: comparison of post-biopsy hematoma rates and risk factors. ... Ultrasound-guided fine needle aspiration versus core needle biopsy : comparison of post-biopsy hematoma rates and risk factors. ... Ultrasound-guided fine needle aspiration versus core needle biopsy : comparison of post-biopsy hematoma rates and risk factors ... T1 - Ultrasound-guided fine needle aspiration versus core needle biopsy. T2 - comparison of post-biopsy hematoma rates and risk ...
Endoscopic ultrasound (EUS) fine needle aspiration (FNA) biopsy is commonly used in the diagnosis of pancreatic tumors. ... Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions. Am J ... Serous cystadenoma of the pancreas with endoscopic ultrasound fine needle aspiration biopsy and surgical correlation. Acta ... limitations and pitfalls of endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer 2008; 114: 102-10. ...
... and biopsy (FNB) has been widely accepted as a fundamental procedure for the diagnosis and staging of lesions of the ... Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) ... EUS-fine needle aspiration (FNA) vs. EUS-fine needle biopsy ( ... Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and biopsy (FNB) has been widely accepted as a fundamental ... Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination. HPB ( ...
... a team of pediatric pathologists who diagnose a vast array of tissue biopsies. ... Pediatric Fine Needle Aspirate Biopsy Pediatric Fine Needle Aspirate Biopsy Superficial fine needle aspirates of superficially ...
... is a procedure in which a small-caliber needle is placed into a mass, cellular material is removed, and a cytologic diagnosis ... encoded search term (Biopsy%2C Fine Needle%2C Neck Mass) and Biopsy, Fine Needle, Neck Mass What to Read Next on Medscape. ... One fatality resulting from a fine needle biopsy of a neck mass has been reported. The death followed fine needle biopsy of a ... Twenty-one-gauge needles provide more cellular samples than twenty-five-gauge needles in fine-needle aspiration biopsy of the ...
Letter: Fatality after fine-needle aspiration biopsy of liver. Br Med J 1975; 1 :517 ... Letter: Fatality after fine-needle aspiration biopsy of liver.. Br Med J 1975; 1 doi: https://doi.org/10.1136/bmj.1.5956.517-a ...
You have been referred for a Fine Needle Aspiration biopsy (FNA) by your health care provider. This is because a lump was ... Question What is a Fine Needle Aspiration biopsy (FNA)?. Answer. You have been referred for a Fine Needle Aspiration biopsy ( ... Biopsies. What is a Fine Needle Aspiration biopsy (FNA)?. How is the FNA biopsy performed?. How long does it take?. When do I ... Almost all biopsies of suspicious breast masses used to be open surgical biopsies. Now more options are available. Fine needle ...
A biopsy is a procedure to remove and examine a sample of tissue from a lump or suspicious area of the body. Visit Nuffield ... Fine needle biopsy A biopsy is a procedure to remove and examine a sample of tissue from a lump or suspicious area of the body ... What happens during fine needle biopsy?. A local anaesthetic is injected first to numb the area. If the lump is near the ... A fine needle is put into the lump to take a sample of cells. Several samples may be taken. ...
A Diagnostic Approach to Fine Needle Aspiration Biopsy - 1st Edition. Print Book & E-Book. ISBN 9781416057697, 9781455728558 ... Chapter 2: Fine Needle Aspiration Biopsy Cytology of Salivary Gland/Head and Neck Lesions: A Diagnostic Approach Based on ... Chapter 8: Fine Needle Aspiration Biopsy Cytology of Lung/Mediastinum: A Diagnostic Approach Based on Pattern Recognition ... Chapter 3: Fine Needle Aspiration Biopsy Cytology of Lymph Nodes: A Diagnostic Approach Based on Pattern Recognition ...
Learn more about Fine Needle Biopsy at St. Davids HealthCare DefinitionReasons for ProcedurePossible ComplicationsWhat to ... A biopsy is a procedure to remove a tissue sample. In a fine needle biopsy (FNB), fluid and cells are removed with a thin, ... Fine needle aspiration, fluid aspiration, and/or core biopsy. National Institute of Health Patient Education website. Available ... Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. UCSF Health website. Available at: https://www.ucsfhealth. ...
Learn more about Fine Needle Biopsy at St. Davids HealthCare DefinitionReasons for ProcedurePossible ComplicationsWhat to ... A biopsy is a procedure to remove a tissue sample. In a fine needle biopsy (FNB), fluid and cells are removed with a thin, ... Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. University of California San Francisco Medical Center ... Fine needle aspiration, fluid aspiration, and/or core biopsy. National Institute of Health Patient Education website. Available ...
Care guide for Fine Needle Breast Biopsy (Ambulatory Care). Includes: possible causes, signs and symptoms, standard treatment ... Learn more about Fine Needle Breast Biopsy (Ambulatory Care). Micromedex® Care Notes. *Core Needle Breast Biopsy ... What you need to know about a fine needle breast biopsy (FNBB):. A FNBB is a procedure to remove a sample of fluid or tissue ... The biopsy needle may make a hole in your lung and cause trouble breathing. You may need other treatments to fix the hole. ...
A fine needle aspiration biopsy of a thyroid nodule is a simple and safe procedure performed in the doctors office. Typically ... For the biopsy, your doctor will use a very thin needle to withdraw cells from the thyroid nodule. The needle used is smaller ... WHAT IS A FINE NEEDLE ASPIRATION BIOPSY (FNA OR FNAB) OF A THYROID NODULE? ... Fine Needle Aspiration Biopsy of Thyroid Nodules. Procedure and interpretation of results ...
Home , What Is A Fine Needle Aspiration Biopsy? - Dr. Terris (VIDEO). What Is A Fine Needle Aspiration Biopsy? - Dr. Terris ( ... www.empowher.com/thyroid-conditions/content/what-fine-needle-aspiration-biopsy-dr-terris-video ...
Read our Fine-Needle Aspiration Biopsy of the Breast encyclopedia resources online. ... In a fine-needle aspiration biopsy of the breast, your doctor inserts a thin needle into a lump and removes a sample of cells ... Fine-Needle Aspiration Biopsy of the Breast. Based on a photograph courtesy of the National Cancer Institute. All rights ... Fine-Needle Aspiration Biopsy of the Breast. « Previous Page En Español ...
Advances in molecular diagnostics in the last 15 to 20 years have moved fine-needle aspiration biopsy (FNAB) beyond mere ... noted that core needle biopsies provide a larger sample than fine-needle biopsies but have a much higher complication rate. As ... Fine-Needle Aspiration Biopsy for Ocular and Orbital Tumors Written By: Marianne Doran, Contributing Writer. Interviewing J. ... Advances in molecular diagnostics in the last 15 to 20 years have moved fine-needle aspiration biopsy (FNAB) beyond mere ...
The accuracy of 250 fine needle biopsies of renal tumors.. Wunderlich H1, Hindermann W, Al Mustafa AM, Reichelt O, Junker K, ... Re: The accuracy of 250 fine needle biopsies of renal tumors. [J Urol. 2005] ... After radical or partial nephrectomy 250 renal tumor biopsies were performed in 50 patients. All biopsies were performed by 1 ... Core biopsy of renal lesions is accurate enough for histopathological evaluation and determination of therapeutic procedure. ...
Fine-Needle Aspiration Biopsy (FNAB) Techniques, at CLSI. Find additional laboratory standards documents in the CLSI Shop. ... This document contains recommended procedures for performing fine needle aspiration biopsies of superficial (palpable) and deep ...
Current and accurate information for patients about thyroid biopsy. Learn what you might experience, how to prepare for the ... What is Ultrasound-Guided Fine Needle Aspiration Biopsy of the Thyroid?. During a fine needle aspiration biopsy of the thyroid ... The needle used is a thin, fine-gauge needle that is smaller in diameter than the needle used in most blood draws (usually a 25 ... An ultrasound-guided fine needle aspiration biopsy uses sound waves to help locate a nodule or abnormality within the thyroid ...
Fine Needle Biopsy. (FNB). by Cynthia M. Johnson, MA. Definition. A biopsy is a procedure to remove a tissue sample. In a fine ... needle_aspiration_biopsy/index.html. Accessed March 26, 2018.. Fine needle aspiration biopsy. American Academy of ... Fine needle aspiration, fluid aspiration, and/or core biopsy. National Institute of Health Patient Education website. Available ... Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. UCSF Health website. Available at: https://www.ucsfhealth. ...
Solitary pleural amyloid nodules occurring as coin lesions diagnosed by fine-needle aspiration biopsy.. Kaw YT1, Esparza AR. ... This report describes two cases of this entity diagnosed by fine-needle aspiration biopsy in patients without systemic amyloid ...
Evaluation of the effectivity of the new thyroid fine needle aspiration biopsy (FNAB) apparatus of which patented from Turkish ... New Thyroid Fine Needle Biopsy Apparatus. The author group of this investigation produced a new thyroid fine needle aspiration ... New Thyroid Fine Needle Biopsy Apparatus. Trial Phase:. N/A. Minimum Age:. 17 Years. Maximum Age:. 85 Years ... fine needle aspiration biopsy indicated noduler goiter patients. Exclusion Criteria:. - diffuse goiter. ...
... ... BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the preferred modality for the cytological ... The total number of needle passes was 105 in group I (mean 2.14 passes per patient; range one to five needle passes) and 158 in ... This appears to be independent of the total number of needle passes undertaken for tissue sampling. ...
Fine Needle Aspiration Biopsy. As with all forms of cancer, thyroid cancer is diagnosed from the results of a biopsy. To ... To get more details about FNA, read our article about fine needle aspiration biopsy. ... benefit of ultrasound is that it helps doctors accurately guide the needle when they perform a fine needle aspiration biopsy. ... doctors use a fine needle aspiration biopsy (FNA). This is usually the first test doctors will use if they suspect thyroid ...
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has been integral in transforming endoscopic GI practice from ... Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has been integral in transforming endoscopic GI practice from ...
  • In humans, free-hand computed tomography (CT)-guided biopsy is an accurate method to obtain a tissue sample. (avmi.net)
  • If any of the three indicate a high degree of concern for cancer, then an open biopsy is carried out. (cancersupportivecare.com)
  • By using this combination method, the frequency of missed cancers can be brought to 1% or less, which is comparable to the miss rate when using open biopsy alone. (cancersupportivecare.com)
  • furthermore a subsequent curative parotid surgery can be complicated by a previous open biopsy. (springer.com)
  • Higher failure rates were observed in specimens submitted for lung cancer panel and melanoma panel (3.1% and 3.7% vs 1.0% colorectal cancer panel), metastatic bone specimens (36% vs 2.6% nonbone specimens), referred specimens (5.0% vs 1.8% in-house specimens), and small biopsy and FNA specimens (5.8% and 3.1% vs 0.7% resection/excision specimens). (elsevier.com)
  • Test feasibility was higher in in-house specimens than referred specimens (99.1% vs 96.9% in resection specimens, 94.4% vs 87.3% in small biopsy specimens, and 94.3% vs 58.8% in FNA specimens). (elsevier.com)
  • 1-3 Therefore, clinical trials evaluating personalised treatment in pancreatic cancer prefer tissue procurement via percutaneous or surgical biopsies over EUS-FNA. (bmj.com)
  • The decision whether to perform a biopsy or FNA is usually made by the referring doctor and/or radiologist depending on the question that needs to be answered, the body part and the ease of access to this area. (melbourneradiology.com.au)
  • Sampling internal tissues may require confirmation of adequate hemostasis (eg, adequate platelet concentration, normal coagulation testing), patient sedation, ultrasonographic guidance, and longer biopsy needles. (productsgroup.com)
  • A fine needle biopsy (FNB) is used to evaluate tissues for abnormal cells, disease, cancer, or infection. (mycdi.com)