We are interested in questions of how the genetic components of an organism are organized on the genome to carryout functions such as development even in the face of significant environmental variations. However, to rigorously answer these questions, we need to first understand how changes in genome organization lead to changes in the timing and level of gene expression. However our efforts to create empirical computational models based on observations of the primary genetic elements and mechanisms governing gene expression have fallen short of providing system-level predictive capacity. It is unclear whether the differences between our measurements and models are due to our inability to parameterize and simulate the complex biophysical processes involved, or our understanding of the biophysical processes is just incorrect or incomplete. Moving forward, instead of further studying wild-type T7, we can try encoding our understanding of the biophysical processes onto a new genome. We will try to ...

Fowler, David; Leith, Ian. 1985 Biophysical mechanisms in the update of air-pollutants. Staub Reinhaltung der Luft, 45. 253-256. Full text not available from this repository. (Request a copy ...

Molecular and Biophysical Mechanisms of Arousal Alertness | D Pfaff | Blackwell Science. Książki i inne produkty w niskich cenach w księgarni internetowej czytam.pl.

Aggregation of amyloid proteins is believed to play a central role in many neurodegenerative diseases, including Parkinsons disease. Now, a collaborative study by Indian researchers has explored certain key biophysical processes that are involved in the initial steps of this process, providing u...

The distribution of survival times of rats subjected to acceleration stress of 20 Gz conforms to the Roginsky-Zeldovich or Elovich equation. This equation is derived from the hypothesis of electron or ion conduction across an activation energy barrier at the surface of a cell or subcellular particle, which suggests that tolerance to this acceleration stress is dependent upon such a biophysical process. Author

Light and Skin Interactions immerses you in one of the most fascinating application areas of computer graphics: appearance simulation. The book first illuminates the fundamental biophysical processes that affect skin appearance, and reviews seminal...

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced that its technology is being used by the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) to make advancements in tackling specific problems in human health and disease such as understanding different biophysical processes, including mechanisms of viral diseases and immunity. Due to the vital research conducted within the LMB, best i

Breathing is the biophysical process which involves the inhaling and exhaling of air through lungs, whereas respiration is the biochemical process which involves in generating the energy by breaking down the glucose which is further used by cells in various function.

Coupled models of ecology and economic growth can provide key insights into the formation of poverty traps that arise from complex interactions between biosocial and biophysical processes.

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Competing models of mitochondrial energy metabolism in the heart are highly disputed. In addition, the mechanisms of reactive oxygen species (ROS) production and scavenging are not well understood. To deepen our understanding of these processes, a computer model was developed to integrate the biophysical processes of oxidative phosphorylation and ROS generation. The model was calibrated with experimental data obtained from isolated rat heart mitochondria subjected to physiological conditions and workloads. Model simulations show that changes in the quinone pool redox state are responsible for the apparent inorganic phosphate activation of complex III. Model simulations predict that complex III is responsible for more ROS production during physiological working conditions relative to complex I. However, this relationship is reversed under pathological conditions. Finally, model analysis reveals how a highly reduced quinone pool caused by elevated levels of succinate is likely responsible for the ...

Proceedings of the symposium held on 11-14 September 2001 at the University of Sheffield, UK. This Symposium provided a snapshot of where we currently stand in exploiting SAR data to understand geophysical and biophysical processes. It identified important areas for future research, in terms of specific problems and general trends: in total, 80 papers were presented on Forestry, Agriculture and Land Cover, Hazards and DTM, Soils and Hydrology, Snow and Ice, Process Modelling.. ...

Proceedings of the symposium held on 11-14 September 2001 at the University of Sheffield, UK. This Symposium provided a snapshot of where we currently stand in exploiting SAR data to understand geophysical and biophysical processes. It identified important areas for future research, in terms of specific problems and general trends: in total, 80 papers were presented on Forestry, Agriculture and Land Cover, Hazards and DTM, Soils and Hydrology, Snow and Ice, Process Modelling.. ...

Two limitations of Dynamic clamp are entirely technical: it has to be fast and temporally consistent. The time required for reading the membrane potential and calculating the current to inject has to be faster than the fastest time constant in the real neuron. This becomes problematic when the model is computationally intensive (as with stochastic Markov models). With ever increasing computer processor speeds, the speed limitation of dynamic clamp is constantly being pushed back. The update interval of the dynamic clamp has to be reliable and reproducible. Modern operating systems (OS) such as Linux, Mac OS, and Windows suffer from the inability of a program running on the OS to be guaranteed a requested operation will be performed precisely when it is requested. Operating systems that can guarantee a request is performed within a well defined time window are Linux with the RTLinux kernel extension, LabView with the real time module, and DOS. A version of dynamic clamp developed by R. Pinto ...

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We aimed at providing an accurate estimation of human brain tissue electrical conductivity in clinico, using local, low-intensity pulsed stimulation. Methods: Using the quasi-static approximation of Maxwell equations, we derived an analytical model of the electric field generated by intracerebral stereotactic-EEG (SEEG) electrodes. We coupled this electric field model with a model of the electrode-electrolyte interface to provide an explicit, analytical expression of brain tissue conductivity based on the recorded brain tissue response to pulse stimulation. Results: We validated our biophysical model using: i) saline solutions calibrated in electrical conductivity, ii) rat brain tissue, and iii) electrophysiological data recorded in clinico from two epileptic patients during SEEG. Conclusion: This new model-based method offers a fast and reliable estimation of brain tissue electrical conductivity by accounting for contributions from the electrode-electrolyte interface. Significance: This method

Bioengineering research at the University of Vermont focuses on the application of quantitative engineering analysis to the study of biological systems.. The goal of this program is the development and implementation of computational and experimental engineering approaches for describing, analyzing, and predicting the behavior of complex biological systems at multiple scales. We consider scales ranging from the molecular level to the cell, tissue, organ, organism, and population levels. Emphasis is placed on understanding how biochemical, biomechanical and/or other biophysical processes interact and influence emergent properties at these different levels.. Areas of expertise in the program are:. Regenerative Medicine. Tissue ...

I am a Research Geologist for the USGS Southwest Biological Science Center (SBSC), and the Grand Canyon Monitoring and Research Center (GCMRC), in Flagstaff, Arizona. I am also an adjunct professor of the School of Earth and Sustainability (SES) at Northern Arizona University. Previously, I was a Mendenhall Fellow with the USGS Western Geographic Science Center located at the University of Arizona in Tucson. I have a Ph.D. in Engineering and Applied Science from the Geosciences Department at Idaho State University.. Overall, my research focus is on geomorphic and ecosystem processes and function of rivers and upland environments. I characterize and interpret physical and biological land surface change that occurs contemporarily at intra-annual to decadal time scales. I study changes that occur as a function of soil erosion and sediment transport. I also study biophysical processes that change the distribution and composition of vegetation. Many of the land surface changes I study are driven by ...

Research Interests: Understanding ecosystems and landscapes as complex systems in which human and biophysical processes are coupled across multiple scales of space and time; incorporating complexity into natural resource management approaches; regional-scale landscape modelling; social-ecological networks; agent and individual-based modelling approaches; landscape science and scenario building ...

The early extraction is important, since the active ingredient is at the peak then.. • Only released after control of possible residues (e.g. antibiotics). • Freed from all undesired components (fat, large-molecule proteins, germs and others) by means of newly-developed gentle and biophysical processes. • After degreasing, it is de-caseinated. This way, a clearing of the liquid and a high active ingredient in the final product is secured. The ingredients are found in free form. That is a huge advantage since the gut absorbs the ingredients directly without the stomach having to digest it. The consequence: a clearly quicker perception of the desired effect.*. • During the entire production, chemical substances and preservatives are dispensed with so that the colostral agents remain bioactive. • Preservation according to pharmaceutical standards by cold sterile filtration. It is thus free of all kinds of germs.. • Turned into powder by a gentle lyophilisation process. The ...

The early extraction is important, since the active ingredient is at the peak then.. • Only released after control of possible residues (e.g. antibiotics). • Freed from all undesired components (fat, large-molecule proteins, germs and others) by means of newly-developed gentle and biophysical processes. • After degreasing, it is de-caseinated. This way, a clearing of the liquid and a high active ingredient in the final product is secured. The ingredients are found in free form. That is a huge advantage since the gut absorbs the ingredients directly without the stomach having to digest it. The consequence: a clearly quicker perception of the desired effect.*. • During the entire production, chemical substances and preservatives are dispensed with so that the colostral agents remain bioactive. • Preservation according to pharmaceutical standards by cold sterile filtration. It is thus free of all kinds of germs.. • Turned into powder by a gentle lyophilisation process. The ...

apr/05_0213.htm.. Robert Burton, an English Anglican priest, was one of the most educated and widely read men of his day. He lived from 1577 to 1640 and is remembered for his influential treatise, The Anatomy of Melancholy (1). Lacking knowledge of biophysical processes, early healers sought to develop models for the treatment of mental illness. In Anatomy, Burton reviews this history as well as the most modern theories of the 17th century. At that time, melancholy referred to all mental diseases and conditions and was considered one of four humours that controlled body systems: blood was a hot, sweet, red humour; phlegm was cold and moist; and choler was hot and dry. But melancholy was cold and dry, thick, black, and sour, begotten of the more feculent part of nourishment, and purged from the spleen. In the 17th century, treatment for an imbalance in melancholy might have included teas, infusions, or broths of laurel, white hellebore, bugloss, marigold, or pennyroyal - or even bloodletting ...

TY - GEN. T1 - Robustness and optimality of decision making under norepinephrine modulation: A biophysical model of the neural substrate. AU - Eckhoff, Philip. AU - Wong-Lin, KongFatt. AU - Holmes, Philip. PY - 2008. Y1 - 2008. M3 - Conference contribution. BT - Unknown Host Publication. PB - Society for Neuroscience. T2 - Society for Neuroscience meeting 2008. Y2 - 1 January 2008. ER - ...

Rioting historically has been known to cause changes in individual cognition, with heightened emotionality, increased excitement and reduced reflective thought. A cross-disciplinary literature review hypothesises emotional states generate corresponding metabolic bio magnetic fields that radiate in patterns reflecting these emotional states. The oscillatory phase of these waves is advanced as being more significant than the power of signal, permitting stochastic effects to magnify signals by appropriating ambient noise. Possible transmission and detection structures in the body are discussed, induced paramagnetic sensitivity in crowd participants in a phase transition process is hypothesised, the effect may be proportional to crowd numbers. It is suspected that positive effects seen in Transcranial Magnetic Therapy used to treat depression may be operating on this mechanism, acting on natural receptors in the limbic system which also capture light and are implicated in mood transitions. A number of

New interdisciplinary facility will house 38 researchers across a variety of disciplines and aims to become a world-leading institute in understanding biophysical mechanisms of disease.

Zeng, Y. [曾毅博]. (2009). Biophysical characterization hpn-like (HPNL), a histidine- and glutamine-rich protein. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_ ...

Biophysics is the study of the interaction of biological systems and physical forces with which they come in contact. There are only 3 types of general forces that can affect biology and they effect it in only one of two ways. Beneficial/Nourishment or Detrimental/Poison. 1) Biochemical- Man made chemicals, foods,

Learn about Regis College biophysics. There are a variety of engineering training programs that may appeal to you, such as mechanics, vehicle design, and alternative energy production.

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Representative input-output curves between P1 and P9.A: P2 cell: example individual traces and input-output curve in the VCN-LSO pathway. As shown here, input-o

INTRODUCTION: Multi-Regional Input-Output (MRIO) analysis makes it possible to track how an impact on any of the 546 IMPLAN Industries in...

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Purpose: : To search for proteins that bind to the Usher syndrome type 3 protein Clarin-1. Methods: : Yeast two-hybrid screening (Fields method) was performed using three baits representing the two predicted extra-cellular loops and the intracellular C-terminal region of the mouse Clarin-1 protein. The expression of recombinant GAL4-baits was confirmed by Western blot analysis. Suitability of the baits for screening was additionally confirmed by transactivation activity tests. Each of the baits was used to screen approximately 1.5 million mouse brain cDNAs for interaction. Isolated positive clones were identified by DNA sequencing and database searching. Potential interaction partners of Clarin-1 were subjected to the mating assay. Results: : Screening the mouse cDNA library with three GAL4-Clarin-1 baits identified 125 positive clones that potentially bind to Clarin-1. 110 of the clones were sequenced, of which 41 were in the correct reading frame with GAL4. Most of those 41 clones were ...

Capturing patient- or condition-specific intervertebral disk (IVD) properties in finite element models is outmost important in order to explore how biomechanical and biophysical processes may interact in spine diseases. However, disk degenerative changes are often modeled through equations similar to those employed for healthy organs, which might not be valid. As for the simulated effects of degenerative changes, they likely depend on specific disk geometries. Accordingly, we explored the ability of continuum tissue models to simulate disk degenerative changes. We further used the results in order to assess the interplay between these simulated changes and particular IVD morphologies, in relation to disk cell nutrition, a potentially important factor in disk tissue regulation. A protocol to derive patient-specific computational models from clinical images was applied to different spine specimens. In vitro, IVD creep tests were used to optimize poro-hyperelastic input material parameters in these ...

Dead sporulating female fly cadavers infected by the house fly-pathogenic fungus Entomophthora muscae are attractive to healthy male flies, which by their physical inspection may mechanically trigger spore release and by their movement create whirlwind airflows that covers them in infectious conidia. The fungal artillery of E. muscae protrudes outward from the fly cadaver, and consists of a plethora of micrometric stalks that each uses a liquid-based turgor pressure build-up to eject a jet of protoplasm and the initially attached spore. The biophysical processes that regulate the release and range of spores, however, are unknown. To study the physics of ejection, we design a biomimetic soft cannon that consists of a millimetric elastomeric barrel filled with fluid and plugged with a projectile. We precisely control the maximum pressure leading up to the ejection, and study the cannon efficiency as a function of its geometry and wall elasticity. In particular, we predict that ejection velocity ...

Downloadable (with restrictions)! Â Crop-livestock farms are complex systems. The interactions operating in such systems involve decisional, biophysical, structural, and environmental factors. Moreover, as farmers face a large range of management options, tools are needed to support their decision-making to enable them to reach production levels meeting their objectives and compatible with their human and physical resources, while controlling their effects on the environment. Gamede, a whole-dairy-farm model, has been developed to explore this complexity and to represent dynamically the effect of management decisions on biomass and nitrogen flows and on numerous sustainability indicators, such as milk and forage crop productivity, labour requirements, nitrogen balance, and nitrogen efficiency. This article describes the integration of six modules accounting for biophysical processes in a dairy farm (forage production; forage conditioning; herd demography; milk, excreta and animal biomass productions;

Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images ...

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The Biophysical Society offers a summer research program, resources on how to find a biophysics program and guidelines on how to start a biophysics program.

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Biophysics or biological physics is an interdisciplinary science that applies the approaches and methods of physics to study biological systems.

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Det medisinske fakultet (UiO), ble grunnlagt i 1814 og er landets eldste medisinske fakultet. Fakultetets kjernevirksomhet er forskning, utdanning og formidling til pasientens og samfunnets beste.