We are interested in questions of how the genetic components of an organism are organized on the genome to carryout functions such as development even in the face of significant environmental variations. However, to rigorously answer these questions, we need to first understand how changes in genome organization lead to changes in the timing and level of gene expression. However our efforts to create empirical computational models based on observations of the primary genetic elements and mechanisms governing gene expression have fallen short of providing system-level predictive capacity. It is unclear whether the differences between our measurements and models are due to our inability to parameterize and simulate the complex biophysical processes involved, or our understanding of the biophysical processes is just incorrect or incomplete. Moving forward, instead of further studying wild-type T7, we can try encoding our understanding of the biophysical processes onto a new genome. We will try to ...

Light and Skin Interactions immerses you in one of the most fascinating application areas of computer graphics: appearance simulation. The book first illuminates the fundamental biophysical processes that affect skin appearance, and reviews seminal...

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced that its technology is being used by the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) to make advancements in tackling specific problems in human health and disease such as understanding different biophysical processes, including mechanisms of viral diseases and immunity. Due to the vital research conducted within the LMB, best i

Coupled models of ecology and economic growth can provide key insights into the formation of poverty traps that arise from complex interactions between biosocial and biophysical processes.

Competing models of mitochondrial energy metabolism in the heart are highly disputed. In addition, the mechanisms of reactive oxygen species (ROS) production and scavenging are not well understood. To deepen our understanding of these processes, a computer model was developed to integrate the biophysical processes of oxidative phosphorylation and ROS generation. The model was calibrated with experimental data obtained from isolated rat heart mitochondria subjected to physiological conditions and workloads. Model simulations show that changes in the quinone pool redox state are responsible for the apparent inorganic phosphate activation of complex III. Model simulations predict that complex III is responsible for more ROS production during physiological working conditions relative to complex I. However, this relationship is reversed under pathological conditions. Finally, model analysis reveals how a highly reduced quinone pool caused by elevated levels of succinate is likely responsible for the ...

Two limitations of Dynamic clamp are entirely technical: it has to be fast and temporally consistent. The time required for reading the membrane potential and calculating the current to inject has to be faster than the fastest time constant in the real neuron. This becomes problematic when the model is computationally intensive (as with stochastic Markov models). With ever increasing computer processor speeds, the speed limitation of dynamic clamp is constantly being pushed back. The update interval of the dynamic clamp has to be reliable and reproducible. Modern operating systems (OS) such as Linux, Mac OS, and Windows suffer from the inability of a program running on the OS to be guaranteed a requested operation will be performed precisely when it is requested. Operating systems that can guarantee a request is performed within a well defined time window are Linux with the RTLinux kernel extension, LabView with the real time module, and DOS. A version of dynamic clamp developed by R. Pinto ...

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The early extraction is important, since the active ingredient is at the peak then.. • Only released after control of possible residues (e.g. antibiotics). • Freed from all undesired components (fat, large-molecule proteins, germs and others) by means of newly-developed gentle and biophysical processes. • After degreasing, it is de-caseinated. This way, a clearing of the liquid and a high active ingredient in the final product is secured. The ingredients are found in free form. That is a huge advantage since the gut absorbs the ingredients directly without the stomach having to digest it. The consequence: a clearly quicker perception of the desired effect.*. • During the entire production, chemical substances and preservatives are dispensed with so that the colostral agents remain bioactive. • Preservation according to pharmaceutical standards by cold sterile filtration. It is thus free of all kinds of germs.. • Turned into powder by a gentle lyophilisation process. The ...

The early extraction is important, since the active ingredient is at the peak then.. • Only released after control of possible residues (e.g. antibiotics). • Freed from all undesired components (fat, large-molecule proteins, germs and others) by means of newly-developed gentle and biophysical processes. • After degreasing, it is de-caseinated. This way, a clearing of the liquid and a high active ingredient in the final product is secured. The ingredients are found in free form. That is a huge advantage since the gut absorbs the ingredients directly without the stomach having to digest it. The consequence: a clearly quicker perception of the desired effect.*. • During the entire production, chemical substances and preservatives are dispensed with so that the colostral agents remain bioactive. • Preservation according to pharmaceutical standards by cold sterile filtration. It is thus free of all kinds of germs.. • Turned into powder by a gentle lyophilisation process. The ...

apr/05_0213.htm.. Robert Burton, an English Anglican priest, was one of the most educated and widely read men of his day. He lived from 1577 to 1640 and is remembered for his influential treatise, The Anatomy of Melancholy (1). Lacking knowledge of biophysical processes, early healers sought to develop models for the treatment of mental illness. In Anatomy, Burton reviews this history as well as the most modern theories of the 17th century. At that time, melancholy referred to all mental diseases and conditions and was considered one of four humours that controlled body systems: blood was a hot, sweet, red humour; phlegm was cold and moist; and choler was hot and dry. But melancholy was "cold and dry, thick, black, and sour, begotten of the more feculent part of nourishment, and purged from the spleen." In the 17th century, treatment for an imbalance in melancholy might have included teas, infusions, or broths of laurel, white hellebore, bugloss, marigold, or pennyroyal - or even bloodletting ...

Rioting historically has been known to cause changes in individual cognition, with heightened emotionality, increased excitement and reduced reflective thought. A cross-disciplinary literature review hypothesises emotional states generate corresponding metabolic bio magnetic fields that radiate in patterns reflecting these emotional states. The oscillatory phase of these waves is advanced as being more significant than the power of signal, permitting stochastic effects to magnify signals by appropriating ambient noise. Possible transmission and detection structures in the body are discussed, induced paramagnetic sensitivity in crowd participants in a phase transition process is hypothesised, the effect may be proportional to crowd numbers. It is suspected that positive effects seen in Transcranial Magnetic Therapy used to treat depression may be operating on this mechanism, acting on natural receptors in the limbic system which also capture light and are implicated in mood transitions. A number of

Zeng, Y. [曾毅博]. (2009). Biophysical characterization hpn-like (HPNL), a histidine- and glutamine-rich protein. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_ ...

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Representative input-output curves between P1 and P9.A: P2 cell: example individual traces and input-output curve in the VCN-LSO pathway. As shown here, input-o

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Purpose: : To search for proteins that bind to the Usher syndrome type 3 protein Clarin-1. Methods: : Yeast two-hybrid screening (Fields method) was performed using three baits representing the two predicted extra-cellular loops and the intracellular C-terminal region of the mouse Clarin-1 protein. The expression of recombinant GAL4-baits was confirmed by Western blot analysis. Suitability of the baits for screening was additionally confirmed by transactivation activity tests. Each of the baits was used to screen approximately 1.5 million mouse brain cDNAs for interaction. Isolated positive clones were identified by DNA sequencing and database searching. Potential interaction partners of Clarin-1 were subjected to the mating assay. Results: : Screening the mouse cDNA library with three GAL4-Clarin-1 baits identified 125 positive clones that potentially bind to Clarin-1. 110 of the clones were sequenced, of which 41 were in the correct reading frame with GAL4. Most of those 41 clones were ...

Downloadable (with restrictions)! Â Crop-livestock farms are complex systems. The interactions operating in such systems involve decisional, biophysical, structural, and environmental factors. Moreover, as farmers face a large range of management options, tools are needed to support their decision-making to enable them to reach production levels meeting their objectives and compatible with their human and physical resources, while controlling their effects on the environment. Gamede, a whole-dairy-farm model, has been developed to explore this complexity and to represent dynamically the effect of management decisions on biomass and nitrogen flows and on numerous sustainability indicators, such as milk and forage crop productivity, labour requirements, nitrogen balance, and nitrogen efficiency. This article describes the integration of six modules accounting for biophysical processes in a dairy farm (forage production; forage conditioning; herd demography; milk, excreta and animal biomass productions;

Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images ...

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Congratulations to Tri Pham and Clemens Cabernard for their recent publication in iScience!. The paper describes cellular and biophysical mechanisms underlying the formation of sibling cell size asymmetry. They show how during cell division a big and small cell are being formed simultaneously. Sibling cell size asymmetry occurs across animal cells but the underlying mechanisms are not clear. Summary:. Metazoan cells can generate unequal sized sibling cells during cell division. This form of asymmetric cell division depends on spindle geometry and Myosin distribution, but the underlying mechanics are unclear. Here, we use atomic force microscopy and live cell imaging to elucidate the biophysical forces involved in the establishment of physical asymmetry in Drosophila neural stem cells. We show that initial apical cortical expansion is driven by hydrostatic pressure, peaking shortly after anaphase onset, and enabled by a relief of actomyosin contractile tension on the apical cell cortex. An ...

Background/Purpose: Circulating multipotential stromal cells (MSCs) also termed mesenchymal stem cells have previously been implicated in fibroblast mediated polyarticular joint destruction in rheumatoid arthritis (RA). We hypothesized that skeletal trauma (a biophysical process) rather than a biological basis related to RA may account for any MSC circulation. Methods: Deep (femoral) and matched peripheral (antecubital) vein blood was collected from 36 patients undergoing lower limb orthopaedic procedures. Peripheral blood was also taken from 15 early and 11 established RA patients as well as 12 healthy controls. Colony-forming unit-fibroblast (CFU-F) assays and cytometric phenotyping of cells were performed. Molecular characterisation of genes related to MSC function was undertaken in comparison to MSCs from iliac crest and femoral marrows, bone, periosteum, adipose tissue and dermal fibroblasts.. Results: 17/36 femoral vein samples contained CFU-Fs, but only 7/74 peripheral vein samples almost ...

Duties: To support, develop and execute research in sensory biophysics, as part of the research team. The research planned is aimed at elucidating the biophysical mechanisms of electroreception in honeybees and bumblebees. As research progresses, electroreception in other arthropod species will also be investigated. The successful candidate will have a track record in the field of sensory biophysics and/or insect electrophysiology. A key asset will be the capacity to identify and solve problems ... | Requirements: Experience in electrophysiology. Experience in sensory ecological research. Flexible, rigorous, innovative and conscientious approach to work, attention to details in data acquisition and analysis. PhD in Life Sciences. Record of oral and poster presentations at international conference. Publications in peer reviewed journals. Evidence of capability to work in multidisciplinary team...

HANDBOOK OF MODERN BIOPHYSICS Series Editor Thomas Jue, PhD Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-

Correlations in sensory neural networks have both extrinsic and intrinsic origins. Extrinsic or stimulus correlations arise from shared inputs to the network and, thus, depend strongly on the stimulus ensemble. Intrinsic or noise correlations reflect biophysical mechanisms of interactions between neurons, which are expected to be robust to changes in the stimulus ensemble. Despite the importance of this distinction for understanding how sensory networks encode information collectively, no method exists to reliably separate intrinsic interactions from extrinsic correlations in neural activity data, limiting our ability to build predictive models of the network response. In this paper we introduce a general strategy to infer population models of interacting neurons that collectively encode stimulus information. The key to disentangling intrinsic from extrinsic correlations is to infer the couplings between neurons separately from the encoding model and to combine the two using corrections ...

My research focuses on the physical ecology of microorganisms and on microscale transport phenomena. With specific expertise in fluid mechanics, I use carefully controlled microfluidic experiments to understand how physical forces and chemical signals shape the behavior of microorganisms, particuarly in the ocean. My vision is that understanding microscale biophysical mechanisms is paramount to predicting ecosystem-level dynamics.. ...

Medical biophysics is a new field in which researchers use knowledge derived from physics to study the human body for medical purposes. As of 2013, the medical biophysics discipline was so new that ...

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Berkeley Lab researchers have shown that complexes of proteins touted for their potential use as a tool for editing DNA might also serve as an engineering tool for RNA, the molecule that translates DNAs genetic instructions into the production of proteins.. ...

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The SWATT, which is located in southwest Western Australia, incorporates an internationally recognised biodiversity hotspot, the Southwest Botanical Province; a national biodiversity hotspot, the Central and Eastern Avon Wheatbelt; and the evolutionary significant species-rich southwest Interzone, which includes the globally significant Great Western Woodlands. The SWATT also intercepts two nationally significant phytogeographic transitional zones; the Triodia-Acacia line and the Menzies line.. The SWATT captures several biophysical gradients that drive species selection, influence community composition and determine assemblage distributional patterns across the landscape. Some of the ecosystem science questions the SWATT aims to inform include how biodiversity is partitioned across the landscape a) at a gene, species and community level in response to biophysical processes, b) how species, population and regional scale genetic variability responds to biophysical gradients and c) to what extent ...

Giving Blueday 2017 provides a special opportunity to continue the Universitys bicentennial commemoration, and you are asked to consider joining in that day to support the Biophysics programs that you feel most passionate about.. While there will be special donor and social media challenges throughout this day to multiply the impact of your gifts, giving to Biophysics can be done at this or any other time by visiting our website at https://lsa.umich.edu/biophysics. Simply click on the "Give Online" button in the "Be a Victor" box and select the Biophysics program area that you would like to support.. Gifts of all sizes are welcome and can make a big difference for growing our program, so please consider whether you are able to join in on November 28, 2017 and celebrate 200 years at U of M!. To find out more about Giving Blueday, please see http://givingblueday.org/home ...

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Biophysics interfaces physics with biology and medicine and is one of the most rapidly developing areas of physics. Because of their specialized training and knowledge, physicists have made major contributions in revealing the secrets of life and in the treatment of disease. These contributions are of great value to humanity. Moreover, biophysics provides challenging research

2017/Nov/28] Dr. Irene Frischauf and Dr. Rainer Schindl made the cover of Science Signaling with their publication: Calcium regulates many vitally important functions in the body - if the calcium balance is defective, diseases like cancer develop... ... more of Biophysics Researchers: Constant Calcium Uptake Causes Cancer in Cells (Titel) ...

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2017/Nov/28] Dr. Irene Frischauf and Dr. Rainer Schindl made the cover of Science Signaling with their publication: Calcium regulates many vitally important functions in the body - if the calcium balance is defective, diseases like cancer develop... ... more of Biophysics Researchers: Constant Calcium Uptake Causes Cancer in Cells (Titel) ...

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During the course in the classroom and out-of-doors you will learn about: ----- describing the role of radiation, pressure and atmospheric moisture on the development of weather phenomena, including cloud formation, fronts, tornadoes, and cyclones; ----- interpreting data to explain spatial and temporal patterns associated with key biophysical processes, such as hydrology and biologic productivity; ----- interpreting maps to explain the spatial distribution of world climate zones, landforms, and biomes; ----- how to apply your new-found knowledge --- opening your eyes as you travel about the world - be it in the nooks and crannies of Vermont or across the continents and seas. ...

We introduce three- and two-dimensional biophysical models of cardiac excitability derived from a 14-dimensional model of the sinus venosus [Rasmusson, R., et al., 1990. Am. J. Physiol. 259, H352-369]. The reduced models capture normal pacemaking dynamics with a small complement of ionic currents. The two-dimensional model bears some similarities with the Morris-Lecar model [Morris, C., Lecar, H., 1981. Biophysical Journal, 35, 193-213]. Because they were reduced from a biophysical model, both models depend on parameters that were obtained from experimental data. Even though the correspondence with the original model is not exact, parameters may be adjusted to tune the reductions to fit experimental traces. As a consequence, unlike other generic low-dimensional models, the models introduced here provide a means to relate physiologically relevant characteristics of pacemaker potentials such as diastolic depolarization, plateau, and action potential frequency, to biophysical variables such as the relative

We like to bring to your attention the 9th Biophysics and Structure Course of the Intl School of Biological Magnetic Resonance (ISBMR). We kindly ask you share this information with graduate students, postdoctoral fellows, and other colleagues and interested individuals, particularly in the areas of Structural Biology, NMR, Biophysics, Crystallography, Computational Biology, and Biochemistry. Details follow: COURSE TITLE: ISBMR 9th Course: Biophysics and Structure WHEN: 22 June - 2 July 2009 WHERE: Ettore Majorana Foundation and Centre for Scientific Culture, Erice-Sicily, Italy. URL: http://smrl.stanford.edu/erice2009/ Apply online: http://www.stanford.edu/~manolia/erice2009app.fb * COURSE FORMAT and PURPOSE: The format is an Advanced Study Institute (ASI). This course will provide an overview of physical and structural methods in biology and will present technologies related to pathogen detection and treatment using these methods. Both, basic principles and concrete examples will be presented ...

Retinal waves are bursts of activity occurring spontaneously in the developing retina of vertebrate species, contributing to the shaping of the visual system organization and disappear short after birth. Waves during development are a transient process which evolves dynamically exhibiting different features. Based on our previous modelling work [1,2], we now propose a classification of stage II retinal waves patterns as a function of acetylcholine coupling strength and a possible mechanism for waves generation. Our model predicts that spatiotemporal patterns evolve upon maturation or pharmacological manipulation and that waves emerge from a complete homogeneous state without the need of the variability of a neural population. Context & Motivation SACs dynamically change their synaptic coupling upon maturation Coupled cholinergic SACs [3] Cholinergic current evolution upon maturation [4]-70 mV 60mV 0 0.8 88 nM 300 nM 0.2 0.4 0.4 0.2 Bursting sAHP Increase of Calcium load during bursting Calcium controls

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Regulatory and biophysical mechanisms of cell-cell fusion are largely unknown, despite the fundamental requirement for fused cells in eukaryotic development. Only two cellular fusogens that are not of obvious viral origin have been identified to date, both in nematodes. EFF-1 and AFF-1 comprise the FF family and together they are necessary for virtually all somatic cell fusions in C. elegans. Unregulated EFF-1 expression causes lethality due to ectopic fusion between cells not developmentally programmed to fuse, highlighting the necessity of tight fusogen regulation for proper development. ^ Identifying factors that regulate EFF-1 and its paralog AFF-1 could lead to discovery of molecular mechanisms that control cell fusion upstream of the action of a membrane fusogen. Yet, FF proteins are sufficient to fuse heterologous invertebrate cell types, suggesting that they function autonomously in foreign molecular and proteomic environments. The work presented here examines whether a predicted 14-3-3

Epithelial cells maintain an essential barrier despite continuously undergoing mitosis and apoptosis. Biological and biophysical mechanisms have evolved to remove dying cells while maintaining that barrier. Cell extrusion is thought to be driven by a multicellular filamentous actin ring formed by neighbouring cells, the contraction of which provides the mechanical force for extrusion, with little or no contribution from the dying cell. Here, we use live confocal imaging, providing time-resolved three-dimensional observations of actomyosin dynamics, to reveal new mechanical roles for dying cells in their own extrusion from monolayers. Based on our observations, the clearance of dying cells can be subdivided into two stages. The first, previously unidentified, stage is driven by the dying cell, which exerts tension on its neighbours through the action of a cortical contractile F-actin and myosin ring at the cell apex. The second stage, consistent with previous studies, is driven by a multicellular ...

Equilibrium constants of the main dissociation scheme of cryolite complex anions and corresponding solvation energies are calculated using both the Hartree-Fock and density-functional schemes with direct inclusion of the reaction field into the Hamiltonian in a self-consistent way. The results are compared with previous ,i,a posteriori,/i, static-reaction-field calculations. ,p, ...

The top half concerns calibration of the Teensys input (how it relates a given ADC reading with a membrane potential Vm ). The bottom half concerns calibration of the Teensys output (how it relates a desired dynamic clamp current IDC with an output signal to send to the Teensys DAC output). In other words, the top half calculates the values of inputSlope and inputIntercept, and the bottom half calculates the values of outputSlope and outputIntercept.. First, we run the top half of the GUI, thus fixing inputSlope and inputIntercept. Then we run the bottom half, fixing outputSlope and outputIntercept. The order matters: we need the Teensy to be able to take a good measurement of Vm in order to get the output parameters right.. (5) Change your patch clamp amplifier to I-clamp mode and connect your DAQ systems analog output directly to the command input of your amplifier, bypassing the summing circuit of Fig. 2E. That is, instead of connecting the DAQ systems analog output to VDAQ, connect it ...

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Yan Nieng, a female professor from Beijing-based Tsinghua University, won the 2015 Raymond & Beverly Sackler International Prize in Biophysics on October 7 for seminal

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Tim Mitchison is a systems biologist and a pioneer in the study of cell division. As a graduate student, he proposed the idea of dynamic instability in microtubules. The paradigm-shifting concept that microtubules can switch between growing and shrinking, along with his subsequent discoveries, had a profound effect on the understanding of an important cellular process.. In recent years, Mitchison has been applying his experimental and theoretical expertise on cell divisions key molecular players and basic biophysical processes, particularly those related to the mitotic spindle, to the design of anticancer drugs. He discovered several small-molecule drug leads, including an inhibitor of cell division that progressed to a promising new class of experimental anticancer drugs. After the drug class ultimately failed in the clinic, Mitchison returned to his basic studies to investigate how chemotherapy drugs work at the cellular level in mouse cancer models.. At Harvard Medical School, Mitchison is ...

the congress ensured everyone departed with a distinct memory of the event.. Local hosts for this triennial congress were the British Biophysical Society and the IOPs Biological Physics Group, with support from the International Union of Biophysics (IUPAB) and the European Biophysics Societies (EBSA). When compiling the scientific programme, expert opinion was sought from highly experienced chairs in a very democratic way, resulting in a good global representation of the. vibrant nature of biophysics. The cross-, multi- and interdisciplinary nature of biophysics was evident throughout the five parallel sessions each day.. ...

Understanding the dynamics of biochemical networks is important for understanding life at the systems level and has practical implications for Medicine, Engineering, Biology, and Chemistry. The complex network of hemostasis consists of over 100 coupled reactions and has the death-defying function of regulating blood coagulation. Research in my laboratory focuses on three problems related to blood coagulation: i) understanding the biophysical mechanisms by which blood clots form and degrade, ii) controlling these processes to eliminate unwanted coagulation, and iii) using coagulation as a scaffold for delivering therapeutics to diseased vasculature. This research lies at the interface of Chemical Biology, Bioengineering and Medicine. The techniques we use include microfluidics, reconstituted protein systems, biomaterial synthesis, numerical simulations, and disease models of coagulation and atherosclerosis. For more information, please visit the Kastrup Lab website: http://kastruplab.msl.ubc.ca/ ...

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Please write to the educational manager, dr. Zsolt Fazekas to the further email addresses in connection with any educational questions: ...

Please write to the educational manager, dr. Zsolt Fazekas to the further email addresses in connection with any educational questions: ...

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Biophysics new findings the science that studies the behavior of individuals, households, and organizations, when they manage or use scarce resources, whic..

I am happy to announce that BIOPHYSICAL-SOCIETY/bionet.prof-society.biophysics is ready for operation. This is a moderated newsgroup intended solely for use by the Biophysical Society for posting official announcements and information. It is not a discussion forum. If you are lucky, you can participate via USENET news, the prefered way. However, e-mail subscriptions can be requested from the U.K. BIOSCI node by contacting biosci at daresbury.ac.uk if you are located in Europe, Africa, or Central Asia. If you are located in the Americas or Pacific Rim, please send the line subscribe bphyssoc to the Internet address biosci-server at net.bio.net and you will be automatically added to the mailing list. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help at net.bio.net ...

Solvent-induced two-photon absorption cross sections are calculated for a push-pull molecule in solutions using both self-consistent reaction field and internal finite field approaches. It is shown analytically and numerically that the results from the two methods can be connected through induced local reaction field factors. The two-photon cross sections of the studied push-pull polyene are found to be rather insensitive to the choice of cavity shape. The solvent dependence of the two-photon absorption displays a pattern different from that of the first hyperpolarizability.. ...

The transition of the human uterus from a quiescent to a contractile state takes place over a number of weeks. On such biological time scales, cellular phenotype is modified by changes in the transcriptome, which in turn is under the control of the underlying endocrine, paracrine, and biophysical processes resulting from the ongoing pregnancy. In this study, we characterize the transition of the human myometrial transcriptome at term from not in labour (NIL) to in labour (LAB) using high throughput RNA sequencing (RNA-seq). RNA was isolated from the myometrium of uterine biopsies from patients at term who were not in labour (n = 5) and at term in spontaneous labour (n = 5) without augmentation. A total of 143.6 million separate reads were sequenced, achieving, on average, ∼13 times coverage of the expressed human transcriptome per sample. Principal component analysis indicated that the NIL and LAB transcriptomes could be distinguished as two distinct clusters. A comparison of the NIL and LAB ...