Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Biomarkers, Pharmacological
Prognosis
Gene Expression Profiling
C-Reactive Protein
ROC Curve
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Metabolomics
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Protein Array Analysis
Sensitivity and Specificity
Early Diagnosis
Lipocalins
A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Mass Spectrometry
Neoplasms
Inflammation
Disease Progression
Oligonucleotide Array Sequence Analysis
MicroRNAs
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Metabolome
Tandem Mass Spectrometry
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Acute-Phase Proteins
Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
Immunoassay
Risk Factors
Blood Proteins
Oxidative Stress
Individualized Medicine
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Prospective Studies
Environmental Exposure
Natriuretic Peptide, Brain
Environmental Monitoring
Validation Studies as Topic
F2-Isoprostanes
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Risk Assessment
Gene Expression Regulation, Neoplastic
Genetic Markers
Interleukin-6
Electrophoresis, Gel, Two-Dimensional
tau Proteins
Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
Saliva
Keratin-18
Isoprostanes
A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
Treatment Outcome
Acute Kidney Injury
Immunohistochemistry
Peptide Fragments
Cluster Analysis
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Severity of Illness Index
Inflammation Mediators
Cystatin C
Urinalysis
Principal Component Analysis
Microarray Analysis
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Cardiovascular Diseases
Endpoint Determination
DNA Adducts
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Magnetic Resonance Imaging
Troponin T
Amyloid beta-Peptides
Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Troponin I
Molecular Targeted Therapy
Early Detection of Cancer
Linear Models
CA-125 Antigen
Algorithms
Multivariate Analysis
Mild Cognitive Impairment
Fibrin Fibrinogen Degradation Products
Pilot Projects
Transcriptome
Follow-Up Studies
Ovarian Neoplasms
Neuroimaging
Specimen Handling
Occupational Exposure
Disease Models, Animal
Diagnostic Imaging
Tissue Array Analysis
Exosomes
Cotinine
Reverse Transcriptase Polymerase Chain Reaction
Pathology, Molecular
Environmental Pollutants
Translational Medical Research
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
DNA Methylation
Real-Time Polymerase Chain Reaction
Longitudinal Studies
Neoplasm Staging
Cross-Sectional Studies
Serum
Cognition Disorders
Gas Chromatography-Mass Spectrometry
Colorectal Neoplasms
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Calcitonin
Positron-Emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Antibodies, Immobilized
Gingival Crevicular Fluid
A fluid occurring in minute amounts in the gingival crevice, believed by some authorities to be an inflammatory exudate and by others to cleanse material from the crevice, containing sticky plasma proteins which improve adhesions of the epithelial attachment, have antimicrobial properties, and exert antibody activity. (From Jablonski, Illustrated Dictionary of Dentistry, 1982)
Statistics, Nonparametric
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Limit of Detection
Cartilage Oligomeric Matrix Protein
Computational Biology
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Chromatography, High Pressure Liquid
Toxicity Tests
Carcinogens
Growth Differentiation Factor 15
A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.
S100 Calcium Binding Protein beta Subunit
Toxicogenetics
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Discriminant Analysis
Aging
Biological Specimen Banks
Logistic Models
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Neoplasms, Glandular and Epithelial
Water Pollutants, Chemical
Carcinoma, Squamous Cell
Meconium
Serum Amyloid A Protein
Reference Values
Pharmacogenetics
Matrilin Proteins
PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.
Epigenesis, Genetic
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.
Glycomics
Analysis of Variance
Dose-Response Relationship, Drug
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Spectrometry, Mass, Electrospray Ionization
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Research Design
Autoantibodies
Precancerous Conditions
Lipid Peroxidation
Pregnancy
Proportional Hazards Models
Models, Biological
Antioxidants
Dietary Supplements
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Epididymal Secretory Proteins
Double-Blind Method
Ki-67 Antigen
S100 Proteins
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Gene Expression
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Plasma
Molecular Imaging
Volatile Organic Compounds
Phenotype
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Haptoglobins
Fibrinogen
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Regression Analysis
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Matrix Metalloproteinase 8
Inhalation Exposure
Genes, Neoplasm
Phthalic Acids
Clusterin
Models, Statistical
Natriuretic Peptides
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. (1/311)
Phosphodiesterase (PDE) 4 inhibitors are a class of drugs that can provide novel therapies for asthma and chronic obstructive pulmonary disease. Their development is frequently hampered by the induction of vascular toxicity in rat mesenteric tissue during preclinical studies. Whereas these vascular lesions in rats have been well characterized histologically, little is known about their pathogenesis and in turn, sensitive and specific biomarkers for preclinical and clinical monitoring do not exist. In order to investigate the early molecular mechanisms underlying vascular injury, time-course studies were performed by treating rats for 2-24 h with high doses of the PDE4 inhibitor CI-1044. Transcriptomics analyses in mesenteric tissue were performed using oligonucleotide microarray and real-time RT-PCR technologies and compared to histopathological observations. In addition, protein measurements were performed in serum samples to identify soluble biomarkers of vascular injury. Our results indicate that molecular alterations preceded the histological observations of inflammatory and necrotic lesions in mesenteric arteries. Some gene expression changes suggest that the development of the lesions could follow a primary modulation of the vascular tone in response to the pharmacological effect of the compound. Activation of genes coding for pro- and antioxidant enzymes, cytokines, adhesion molecules, and tissue inhibitor of metalloproteinase 1 (TIMP-1) indicates that biomechanical stimuli may contribute to vascular oxidant stress, inflammation, and tissue remodeling. TIMP-1 appeared to be an early and sensitive predictive biomarker of the inflammatory and the tissue remodeling components of PDE4 inhibitor-induced vascular injury. (+info)Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches. (2/311)
The Organization for Economic Cooperation and Development (OECD) is currently funding the validation of the Hershberger assay as a rapid in vivo means of identifying (anti-) androgens. However, as the assay measures weight changes in the androgen-sensitive tissues of castrated rats, the evaluation of the androgen-stimulated intact weanling as a more ethical model to use in the assay has been requested. As part of the OECD validation exercise two weak antiandrogens, 1,1-dichloro-2,2-bis(4 chlorophenyl)ethane (DDE) and linuron (LIN), were investigated in our laboratory at several dose levels in the testosterone propionate (TP)-stimulated weanling using flutamide (FM) as a positive control. In addition to weight measurements (sex accessory tissues [SATs], epididymides, and testes), histopathological assessment of the seminal vesicles, prostate, and testes was conducted for vehicle control, TP-stimulated, and TP-stimulated animals treated with FM or the top dose level of DDE or LIN. The modulation of a novel prostate protein associated with apoptosis, L-amino acid oxidase (LAO), was evaluated in these same treatment groups. Our gravimetric data (supported by the histopathology data) indicated that the weanling assay can detect SAT and epididymal weight changes induced by the antiandrogens evaluated. Inconsistent and variable data were recorded for the testicular weight and histopathological effects, suggesting that the testis is of little value in the identification of antiandrogens using this model. Three isoforms of LAO were identified, and all were regulated by TP. Modulation of LAO by the antiandrogens indicated that this protein could be a biomarker for endocrine disruption in male rodents. (+info)Toxicogenomics of drug-induced hemolytic anemia by analyzing gene expression profiles in the spleen. (3/311)
Hemolytic anemia is a serious adverse effect of therapeutic drugs that is caused by increased destruction of drug-damaged erythrocytes by macrophages in the spleen and liver. We previously applied a toxicogenomic approach to the toxicity by analyzing microarray data of the liver of rats dosed with two hemolytic agents: phenylhydrazine and phenacetin. In the present study, we analyzed gene expression profiles in the spleen, the primary organ for destruction of damaged erythrocytes, of the same models in order to identify splenic gene expression alterations that could be used to predict the hematotoxicity. Microarray analyses revealed hundreds of genes commonly deregulated under all severe hemolytic conditions, which included genes related to splenic events characteristic of the hematotoxicity, such as proteolysis and iron metabolism. Eleven upregulated genes were selected as biomarker candidates, and their expression changes were validated by quantitative real-time PCR. The transcript levels of most of these genes showed strong correlation with the results of classical toxicological assays (e.g., histopathology and hematology). Furthermore, hierarchical clustering analysis suggested that altered expression patterns of the 11 genes sensitively reflected the erythrocyte damage even under a condition that caused no decrease in erythrocyte counts. Among the selected genes, heme oxygenase 1 was one of the most promising biomarker candidates, the upregulation of which on the protein level was confirmed by immunohistochemistry. These results indicate that altered splenic expression of a subset of genes may allow detection of drug-induced hemolytic anemia, with better sensitivity than that of erythrocyte counts in the blood. (+info)Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing. (4/311)
Although imatinib is clearly the treatment of choice for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia (CEL), little is known about optimal dosing, duration of treatment, and the possibility of cure in this disorder. To address these questions, 5 patients with FIP1L1/PDGFRA-positive CEL with documented clinical, hematologic, and molecular remission on imatinib (400 mg daily) and without evidence of cardiac involvement were enrolled in a dose de-escalation trial. The imatinib dose was tapered slowly with close follow-up for evidence of clinical, hematologic, and molecular relapse. Two patients with endomyocardial fibrosis were maintained on imatinib 300 to 400 mg daily and served as controls. All 5 patients who underwent dose de-escalation, but neither of the control patients, experienced molecular relapse (P < .05). None developed recurrent symptoms, and eosinophil counts, serum B12, and tryptase levels remained suppressed. Reinitiation of therapy at the prior effective dose led to molecular remission in all 5 patients, although 2 patients subsequently required increased dosing to maintain remission. These data are consistent with suppression rather than elimination of the clonal population in FIP1L1/PDGFRA-positive CEL and suggest that molecular monitoring may be the most useful method in determining optimal dosing without the risk of disease exacerbation. This trial was registered at http://www.clinicaltrials.gov as no. NCT00044304. (+info)Biomarker method validation in anticancer drug development. (5/311)
Over recent years the role of biomarkers in anticancer drug development has expanded across a spectrum of applications ranging from research tool during early discovery to surrogate endpoint in the clinic. However, in Europe when biomarker measurements are performed on samples collected from subjects entered into clinical trials of new investigational agents, laboratories conducting these analyses become subject to the Clinical Trials Regulations. While these regulations are not specific in their requirements of research laboratories, quality assurance and in particular assay validation are essential. This review, therefore, focuses on a discussion of current thinking in biomarker assay validation. Five categories define the majority of biomarker assays from 'absolute quantitation' to 'categorical'. Validation must therefore take account of both the position of the biomarker in the spectrum towards clinical end point and the level of quantitation inherent in the methodology. Biomarker assay validation should be performed ideally in stages on 'a fit for purpose' basis avoiding unnecessarily dogmatic adherence to rigid guidelines but with careful monitoring of progress at the end of each stage. These principles are illustrated with two specific examples: (a) absolute quantitation of protein biomarkers by mass spectrometry and (b) the M30 and M65 ELISA assays as surrogate end points of cell death. (+info)Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants. (6/311)
Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants used in a variety of consumer products. In the past 25 years, PBDEs have become ubiquitous environmental contaminants. They have been detected in soil, air, sediments, birds, marine species, fish, house dust, and human tissues, blood and breast milk. Diet and house dust appear to be the major sources of PBDE exposure in the general population, though occupational exposure can also occur. Levels of PBDEs in human tissues are particularly high in North America, compared to Asian and European countries, and have been increasing in the past 30 years. Concentrations of PBDEs are particularly high in breast milk, resulting in high exposure of infants. In addition, for toddlers, dust has been estimated to account for a large percentage of exposure. PBDEs can also cross the placenta, as they have been detected in fetal blood and liver. Tetra-, penta- and hexaBDEs are most commonly present in human tissues. The current greatest concern for potential adverse effects of PBDEs relates to their developmental neurotoxicity. Pre- or postnatal exposure of mice or rats to various PBDEs has been shown to cause long-lasting changes in spontaneous motor activity, mostly characterized as hyperactivity or decreased habituation, and to disrupt performance in learning and memory tests. While a reduction in circulating thyroid hormone (T(4)) may contribute to the developmental neurotoxicity of PBDEs, direct effects on the developing brain have also been reported. Among these, PBDEs have been shown to affect signal transduction pathways and to cause oxidative stress. Levels of PBDEs causing developmental neurotoxicity in animals are not much dissimilar from levels found in highly exposed infants and toddlers. (+info)Current opinion: safety evaluation of drug metabolites in development of pharmaceuticals. (7/311)
Safety assessment of drug metabolites in the development of pharmaceuticals was discussed in January 2007 at the kick-off meeting of a "Drug Evaluation Forum", with reference to the views of clinicians and other academic representatives. Safety evaluation of metabolites cannot readily be based on a single theoretical framework, and basically a case-by-case approach is called for. These evaluations should be performed precisely and an accurate profile secured taking into account adverse reactions that are unpredictable from the parent compound administered in clinical studies and any signs or symptoms that may be associated with the metabolites. In addition, elimination of scientifically meaningless metabolite safety assessment studies is essential for prompt supply of high-quality drugs to the medical frontline. Preparation of an outline concept paper would be useful for achievement of shared understanding of issues of this type. Collective viewpoints obtained in this fashion are also relevant to the discussion on the need for guidance, and given a degree of flexibility may also be helpful for drug development and, in turn, society at large. (+info)Gene expression profiling of rat liver treated with serum triglyceride-decreasing compounds. (8/311)
We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for interpretation of plasma triglyceride (TG) decrease, we extracted 218 probe sets of rat hepatic genes from data of 15 drugs that decreased the plasma TG level but differentially affected food consumption. Pathway and gene ontology analysis revealed that the genes belong to amino acid metabolism, lipid metabolism and xenobiotics metabolism. Principal component analysis (PCA) showed that 12 out of 15 compounds were separated in the direction of PC1, and these 12 were separated in the direction of PC2, according to their hepatic gene expression profiles. It was found that genes with either large or small eigenvector values in principal component PC 2 were those reported to be regulated by peroxisome proliferator-activated receptor (PPAR)alpha or constitutive androstane receptor (CAR), respectively. In fact, WY-14,643, clofibrate, gemfibrozil and benzbromarone, reported to be PPARalpha activators, distributed to the former, whereas propylthiouracil, omeprazole, phenobarbital, thioacetamide, methapyrilene, sulfasalazine and coumarin did to the latter. We conclude that these identified 218 probe sets could be a useful source of biomarkers for classification of plasma TG decrease, based on the mechanisms involving PPARalpha and CAR. (+info)
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CRAN - Package changepoint
Predictive Biomarkers Featured in New Report | PIH
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Natural Factors - PGX Daily Singles - 30pkts
PGX Diet Pills Review - PGX Fiber Pill - PGX Weight Loss - PGX Reviews
Pharmacogenomics (PGx): Harboring Personalized Medicines | Dec 22, 2014 - ReleaseWire
Bayesian probability - Lesswrongwiki
Global Pharmacogenomics Market Is Expected To Reach USD 11.94 Bn By 2024 - Credence Research | Albany News Now
Pharmacogenomic Market Gaining Greater Acceptance Across Europe
Pharmacogenomics (for Parents) - Hospital Sant Joan de Deu
Probably Overthinking It: October 2011
Is PD-L1 really a predictive biomarker? - ecancer
Dating Site Matches Users By Their DNA; Says That Two Biomarkers Are Essential For Compatibility
AllerGen Investigators - AllerGen
PGX®Daily Ultra Matrix 750 mg - 120 Softgels
DMOZ - Health: Medicine: Pharmacology: Pharmacogenomics
Pharmacogenomics (PGx) Results and Clinical Data of Established Patients with Liver Disease to Assess Current and Future...
Pharmacogenomics: Benefits and Barriers
Biomarkers in Biovista Vizit | Biovista Vizit
pharmacogenomics | Mendelspod
AMANTADIN - UK
BUTAMIRATE - UK
uBiome gone? - Biomarkers & Genes - LONGECITY
Response-driven imaging biomarkers for predicting radiation necrosis of the brain<...
View source for Bayesian probability - Lesswrongwiki
Natural Factors SlimStyles Strawberry Weight Loss Drink Mix with PGX 1 - VitaminLife
Pharmacogenomics Testing Fort Worth | Drug-Gene Testing | Pharmacogenetics TX
The Emerging Role Of Pharmacogenomics In The Treatment Of Patients With Hypertension for Shabeb Reda Abd Elazeem Mohammed
What is Bayesianism? - LessWrong 2.0
Is there a role for pharmacogenetics in the dosing of fentanyl? - Neuro Central
Neuropsychopharmacology
At present, novel pharmacological approaches to diseases or conditions are reported at a rate of almost one per week.[3] So far ... Other cutting-edge studies have focused on genetics to identify specific biomarkers that may predict an individual's specific ... Trends in Pharmacological Sciences. doi:10.1016/j.tips.2018.10.007 Kwako, L. E., Bickel, W. K., & Goldman, D. (2018). Addiction ... It is at this point known with relative certainty that the primary shared effects of a broad pharmacological group of ...
Bipolar disorder
"Brain biomarkers of treatment for multi-domain dysfunction: pharmacological FMRI studies in pediatric mania" ... There are a number of pharmacological and psychotherapeutic techniques used to treat bipolar disorder. Individuals may use self ... Pharmacological treatment of mania increases ventral prefrontal cortex (vPFC) activity, normalizing it relative to controls, ... The literature examining the pharmacological treatment of rapid cycling is sparse and there is no clear consensus with respect ...
Mania
"Brain biomarkers of treatment for multi-domain dysfunction: pharmacological FMRI studies in pediatric mania" ... Goodman, Brunton L, Chabner B, Knollman B (2011). Goodman Gilman's pharmacological basis of therapeuti (Twelfth ed.). New York ... Pharmacological treatment of mania increases ventral prefrontal cortex(vPFC) activity, normalizing it relative to controls, ...
Meldonium
Biochemical mechanisms and biomarkers of cardiometabolic activity". Pharmacological Research. 113 (Pt B): 771-780. doi:10.1016/ ... Dambrova, M; Makrecka-Kuka, M; Vilskersts, R; Makarova, E; Kuka, J; Liepinsh, E (2 February 2016). "Pharmacological effects of ... This has made meldonium a possible pharmacological agent for ischemic preconditioning. The mechanisms underlying the central ...
Doping in figure skating
"Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity". Pharmacological ... A review of its pharmacological properties and therapeutic potential". Drugs. 41 (1): 81-103. doi:10.2165/00003495-199141010- ...
Pharmacoepigenetics
These epigenetic biomarkers are being considered in clinical use as a tool to detect disease, classify tumors, and understand ... Trends in Pharmacological Sciences. 35 (8): 384-96. doi:10.1016/j.tips.2014.05.004. PMID 24993164. Kelly, Theresa K; De ... Ingelman-Sundberg, M; Cascorbi, I (2016). "Pharmacogenomic or -Epigenomic Biomarkers in Drug Treatment: Two Sides of the Same ...
Mate (drink)
Yerba mate: Pharmacological Properties Research and Biotechnology[dead link] "Yerba mate drinking methods". 2011. Archived from ... Biomarkers & Prevention. Cebp.aacrjournals.org. 17 (5): 1262-1268. doi:10.1158/1055-9965.EPI-08-0025. PMID 18483349. Retrieved ...
Brassica oleracea
Pharmacological Research. 55 (3): 224-236. doi:10.1016/j.phrs.2007.01.009. ISSN 1043-6618. PMC 2737735. PMID 17317210. Dixon, G ... Biomarkers & Prevention. 5 (9): 733-748. ISSN 1055-9965. PMID 8877066. Higdon, Jane V.; Delage, Barbara; Williams, David E.; ...
Jason S. Lewis
These probes can be used for biomarkers in clinical trials as well as used as an agent for oncological diagnostics. He has ... "Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer". Proceedings of the National Academy ... "Applying PET to Broaden the Diagnostic Utility of the Clinically Validated CA19.9 Serum Biomarker for Oncology". Journal of ... these probes span from oncological metabolic detection to understanding the biological processes of cancer and pharmacological ...
Aticaprant
... pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker ...
Phosphodiesterase 3
PDE3a expression has been described as a biomarker for sensitivity for PDE3-inhibitor Zardaverine in different types of cancer ... PDE3A and PDE3B have strikingly similar pharmacological and kinetic properties, but the distinction is in expression profiles ... Pharmacological Reviews. 58 (3): 488-520. doi:10.1124/pr.58.3.5. PMID 16968949. S2CID 7397281. Lugnier C (March 2006). "Cyclic ...
Telomerase RNA component
Due to its overexpression in a range of cancer phenotypes, TERC has been investigated as a potential cancer biomarker. It was ... European Review for Medical and Pharmacological Sciences. 24 (2): 526-534. doi:10.26355/eurrev_202001_20029. PMID 32016954. ... February 2020). "Telomere-associated genes and telomeric lncRNAs are biomarker candidates in lung squamous cell carcinoma (LUSC ... found to be an effective biomarker of lung squamous cell carcinoma (LUSC). "Human PubMed Reference:". National Center for ...
Kotinin - Википедија
Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.. ... Kotinin se koristi kao biomarker za izlaganje duvanskom dimu. On je u prodaji kao antidepresiv pod imenom Scotine.[1] ...
Trace amine
A systematic review of ADHD biomarkers also indicated that urinary phenethylamine levels could be a diagnostic biomarker for ... Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends in Pharmacological ... Similarly, urinary biogenic trace amine PEA levels could be a biomarker for the diagnosis of ADHD,20,57,58 for treatment ... In particular, because amphetamine has remained the most effective pharmacological treatment in ADHD for many years, a ...
Hepatocellular carcinoma
A biomarker named six-miRNA signature allows effective treatment of patients with HCC and is able to predict its recurrence in ... it is hoped that identifying the aberrant genes and the resultant proteins could lead to the identification of pharmacological ... biomarkers and therapeutic targets". Journal of Hepatology. 67 (3): 603-618. doi:10.1016/j.jhep.2017.04.009. ISSN 1600-0641. ... and other predictive biomarkers. As similar research is yielding results in various other malignant diseases, ...
Darko Šarović
... and therapeutic biomarkers that can be used to follow up on the effect of pharmacological and therapeutic interventions. " ... He coordinates a project titled "Neurophysiological biomarkers in autism - A magnetoencephalographic study" with the aim of ... both diagnostic biomarkers that can aid the clinical diagnostic procedure, ... finding structural and functional biomarkers for autism using magnetic resonance imaging (MRI) and magnetoencephalography (MEG ...
Medical imaging
Imaging biomarkers (a characteristic that is objectively measured by an imaging technique, which is used as an indicator of ... pharmacological response to a therapy) and surrogate endpoints have shown to facilitate the use of small group sizes, obtaining ...
Multiple sclerosis biomarkers
... pathogenic processes or pharmacological responses to a therapeutic intervention. Type 0 biomarkers are those related to the ... They can be of several types like body fluid biomarkers, imaging biomarkers or genetic biomarkers. They are expected to play an ... It is common to classify them according to their source (imaging biomarkers, body fluid biomarkers and genetic biomarkers) or ... Though biomarkers are normally assumed to be chemical compounds in body fluids, image can also be considered a biomarker. For ...
Hes3 signaling axis
Pharmacological activation of this pathway opposed the progression of neurodegenerative disease in rodent models. More recent ... July 2014). "A defined, controlled culture system for primary bovine chromaffin progenitors reveals novel biomarkers and ... Several pieces of evidence suggest that in the adult brain, pharmacological activation of the STAT3-Ser/Hes3 signaling axis ... Hes3 has been used as a biomarker to identify putative endogenous stem cells in tissues. The pathway is an example of non- ...
Biomarker (medicine)
For instance, pharmacodynamic (PD) biomarkers are markers of a certain pharmacological response, which are of special interest ... or biopsy biomarkers. Molecular biomarkers refer to non-imaging biomarkers that have biophysical properties, which allow their ... disease prognosis biomarkers (cancer biomarkers), and biomarkers for monitoring the clinical response to an intervention (HbAlc ... biomarker is becoming a synonym for molecular biomarker, such as elevated prostate specific antigen as a molecular biomarker ...
Biomarker (cell)
... or pharmacological responses to a therapeutic intervention."Biomarkers characterize disease progression starting from the ... Biomarkers can be classified on their clinical applications as molecular biomarkers, cellular biomarkers or imaging biomarkers ... Four of the main types of molecular biomarkers are genomic biomarkers, transcriptomic biomarkers, proteomic biomarkers and ... Three broad classes of biomarkers are prognostic biomarkers, predictive biomarkers and pharmacodynamic biomarkers. Prognostic ...
Autism Speaks
... supports the Clinical Trials Network, which focuses on new pharmacological treatments. It also supports the ... Diagnosis includes epidemiology, early diagnosis, and biomarkers. Autism therapies include medication, behavioral, and ...
PSMB6
For instance, pharmacological drug therapy with Periplocin in the treatment of rheumatoid arthritis, is also found to inhibit ... predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. As aforementioned, the proteasome ...
Vamorolone
... with blood biomarker data suggesting possible loss of safety concerns of the corticosteroid class In Phase 2a dose-ranging ... Pharmacological Research. 136: 140-150. doi:10.1016/j.phrs.2018.09.007. PMC 6218284. PMID 30219580. Hoffman, Eric P.; Schwartz ... and showed blood biomarker data consistent with a myofiber membrane stabilization and anti-inflammatory effects, and possible ... Week 2 changes of proinflammatory PD biomarkers showed exposure-dependent decreases. The E50 was 260 ng·h/mL for insulin-like ...
Serotonin-norepinephrine-dopamine reuptake inhibitor
2008). "Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen ... "Assessment of biomarkers of drug-induced kidney injury in cynomolgus monkeys treated with a triple reuptake inhibitor". ... Cocaine is a short-acting SNDRI that also exerts auxiliary pharmacological actions on other receptors. Cocaine is a relatively ... 2010). "The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor ...
Plomestane
Morton IK, Hall JM (1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer. p. 227. ISBN 978-0- ... January 1998). "Aromatase inhibitors as potential cancer chemopreventives". Cancer Epidemiology, Biomarkers & Prevention. 7 (1 ... Minamestane Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1635. ISBN 978-0-412-46630-4. Retrieved 19 ...
Calcitonin gene-related peptide
Ferrari MD, Saxena PR (June 1993). "On serotonin and migraine: a clinical and pharmacological review". Cephalalgia. 13 (3): 151 ... Edvinsson L (2006). "Neuronal signal substances as biomarkers of migraine". Headache. 46 (7): 1088-94. doi:10.1111/j.1526- ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacological Reviews. 54 ... Pharmacological Research. 111: 592-599. doi:10.1016/j.phrs.2016.07.015. PMID 27438459. Wang W, Wang EQ, Balthasar JP (November ...
Non-alcoholic fatty liver disease
In terms of pharmacological treatment, the AASLD and EASL do not recommend metformin, but vitamin E may improve liver health ... Some biomarker-based blood tests have been developed and may be useful for diagnosis. Although blood tests cannot diagnose ... Weight loss is associated with improvements in biomarkers, NAFLD grade, and reduced chances of NASH, but their impact on long- ... Wong VW, Adams LA, de Lédinghen V, Wong GL, Sookoian S (August 2018). "Noninvasive biomarkers in NAFLD and NASH - current ...
Genetics of amyotrophic lateral sclerosis
... a valid pharmacological target?". British Journal of Pharmacology. 171 (8): 2191-2205. doi:10.1111/bph.12476. ISSN 0007-1188. ... models and biomarkers in amyotrophic lateral sclerosis". Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14 (1): ...
Glycogen phosphorylase
The brain isoform of glycogen phosphorylase (PYGB) has been proposed as a biomarker for gastric cancer.[21] ... Current Pharmacological Design. 9 (15): 1177-89. doi:10.2174/1381612033454919. PMID 12769745.. ...
Autophagy
Recent pharmacological and biochemical studies have proposed that survival and lethal autophagy can be distinguished by the ... "Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies". Apoptosis: 1-20. doi ...
Phenethylamine
An ADHD biomarker review also indicated that urinary phenethylamine levels could be a diagnostic biomarker for ADHD.[16][25] ... Many of these psychoactive compounds exert their pharmacological effects primarily by modulating monoamine neurotransmitter ... Similarly, urinary biogenic trace amine PEA levels could be a biomarker for the diagnosis of ADHD,20,57,58 for treatment ... Scassellati C, Bonvicini C, Faraone SV, Gennarelli M (October 2012). "Biomarkers and attention-deficit/hyperactivity disorder: ...
Epigenetics
Various pharmacological agents are applied for the production of induced pluripotent stem cells (iPSC) or maintain the ... Epigenetic changes have been found to be reflective of lifestyle and may act as functional biomarkers of disease before ... as well as use it as a biomarker for assessing the efficacy of therapeutic interventions (121,122,124). Some of these proposed ... "Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment". BioMed Research ...
Posttraumatic stress disorder
Part II: focus on pharmacological treatment". Dialogues in Clinical Neuroscience (in English, Spanish, and French). 16 (2): 227 ... Heightened startle responses and a smaller hippocampal volume have been identified as biomarkers for the risk of developing ... Amos T, Stein DJ, Ipser JC (July 2014). "Pharmacological interventions for preventing post-traumatic stress disorder (PTSD)". ... guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first ...
Ataxia
Clinical and pharmacological considerations and treatment". Drug Safety. 6 (4): 247-65. doi:10.2165/00002018-199106040-00003. ... the immune ataxia remains of unknown origin and lacks biomarkers. This entity is called primary auto-immune ataxia (PACA).[32] ... The movement disorders associated with ataxia can be managed by pharmacological treatments and through physical therapy and ...
Atrial fibrillation
Multiple studies have compared pharmacological rate and rhythm strategies but have failed to identify a superior therapy, a ... "Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?". Biomed Res Int. 2015: ...
Parkinson's disease
2006). "Symptomatic pharmacological therapy in Parkinson's disease". Parkinson's Disease. London: Royal College of Physicians. ... "Blood-based biomarkers for Parkinson's disease". Parkinsonism & Related Disorders. 20 Suppl 1: S99-103. doi:10.1016/S1353-8020 ... Connolly BS, Lang AE (23-30 April 2014). "Pharmacological treatment of Parkinson disease: a review". JAMA. 311 (16): 1670-83. ... Tolosa E, Katzenschlager R (2007). "Pharmacological management of Parkinson's disease". In Tolosa E, Jankovic JJ. Parkinson's ...
Sepsis
Biomarkers[edit]. A 2013 review concluded moderate-quality evidence exists to support the use of the procalcitonin level as a ... "Therapeutic interventions in sepsis: Current and anticipated pharmacological agents". British Journal of Pharmacology. 171 (22 ... to try to identify biomarkers and drug targets for intervention.[119] ...
ಹಂಟಿಂಗ್ಟನ್ನ ಕಾಯಿಲೆ - ವಿಕಿಪೀಡಿಯ
"Molecular genetics and biomarkers of polyglutamine diseases". Curr. Mol. Med. 8 (3): 221-34. doi:10.2174/156652408784221298 ... "Advances in the Pharmacological Management of Huntington's Disease". Drugs. 70 (5): 561-71. doi:10.2165/11534430-000000000- ...
Anorexia nervosa
Evidence from physiological, pharmacological and neuroimaging studies suggest serotonin may play a role in anorexia. While ... "Can Interoception Improve the Pragmatic Search for Biomarkers in Psychiatry?". Frontiers in Psychiatry. 7: 121. doi:10.3389/ ...
મદ્યપાન - વિકિપીડિયા
2008). "Biomarkers of alcoholism: an updated review.". Scand J Clin Lab Invest 68 (2): 81-92. doi:10.1080/00365510701532662 . ... Soyka, M.; Rösner, S. (Nov 2008). "Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review ...
Alzheimers sygdom, den frie encyklopædi
Trends in Pharmacological Sciences. 1991;12(10):383-88. doi:10.1016/0165-6147(91)90609-V. PMID 1763432. ... "Alzheimer disease: Epidemiology, Diagnostic Criteria, Risk Factors and Biomarkers". Biochemical Pharmacology. 88 (4): 640-651 ...
13-Hydroxyoctadecadienoic acid
Niki, Etsuo (2014). "Biomarkers of lipid peroxidation in clinical material". Biochimica et Biophysica Acta (BBA) - General ... may be responsible for the airways damage which occurs in the more severe forms of asthma and that pharmacological inhibitors ... "Chemistry of Lipid Peroxidation Products and Their Use as Biomarkers in Early Detection of Diseases". Journal of Oleo Science. ... "Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo". Journal of Clinical ...
Green fluorescent protein
Journal of Pharmacological and Toxicological Methods. 51 (1): 1-23. doi:10.1016/j.vascn.2004.07.006. PMID 15596111.. ... "Fluorescent proteins as biomarkers and biosensors: throwing color lights on molecular and cellular processes". Current Protein ...
Stem-cell therapy
Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery ...
Functional magnetic resonance imaging
Pharmacological fMRI, assaying brain activity after drugs are administered, can be used to check how much a drug penetrates the ... Other biomarkers now looked at to provide better contrast include temperature, acidity/alkalinity (pH), calcium-sensitive ... Newer methods which improve both spatial and time resolution are being researched, and these largely use biomarkers other than ...
GPER
... plays a role in breast cancer progression and tamoxifen resistance.[20] GPER has also been proposed as a biomarker in ... Pharmacological Research. 71: 53-60. doi:10.1016/j.phrs.2013.02.008. PMID 23466742.. ... acts as a vitamin although neither activates the GPR109A nor exhibits the pharmacological properties of nicotinic acid. In the ...
Chronic fatigue syndrome
There is no certain pharmacological treatment or cure for CFS[2] although various drugs have been or are being investigated.[85 ... "Myalgic Encephalomyelitis: Symptoms and Biomarkers". Current Neuropharmacology. 13 (5): 701-734. doi:10.2174/ ...
Ugonjwa wa Alzheimer, kamusi elezo huru
Robinson L, Hutchings D, Dickinson HO, et al. (2007). "Effectiveness and acceptability of non-pharmacological interventions to ... Marksteiner J, Hinterhuber H, Humpel C (Juni 2007). "Cerebrospinal fluid biomarkers for diagnosis of Alzheimer's disease: beta- ... Hermans DG, Htay UH, McShane R (2007). "Non-pharmacological interventions for wandering of people with dementia in the domestic ... Sink KM, Holden KF, Yaffe K (2005). "Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the ...
Neural oscillation
These biomarkers are often named "EEG biomarkers" or "Neurophysiological Biomarkers" and are quantified using Quantitative ... "Oscillatory properties of guinea-pig inferior olivary neurones and their pharmacological modulation: an in vitro study". J ... EEG biomarkers can be extracted from the EEG using the open-source Neurophysiological Biomarker Toolbox. ... Neural oscillations are sensitive to several drugs influencing brain activity; accordingly, biomarkers based on neural ...
Exercise
Biomarkers of inflammation such as C-reactive protein, which are associated with chronic diseases, are reduced in active ... Valero T (2014). "Mitochondrial biogenesis: pharmacological approaches". Curr. Pharm. Des. 20 (35): 5507-09. doi:10.2174/ ... Research that includes direct indices of change in such biomarkers will help to determine the mechanisms by which exercise may ... When compared to psychological or pharmacological therapies, exercise appears to be no more effective, though this conclusion ...
GPR55
Ross RA (Mar 2009). "The enigmatic pharmacology of GPR55". Trends in Pharmacological Sciences. 30 (3): 156-63. doi:10.1016/j. ... in cancer and opens the possibility of considering this orphan receptor as a new therapeutic target and potential biomarker in ... Trends in Pharmacological Sciences. 27 (1): 1-4. doi:10.1016/j.tips.2005.11.003. PMID 16318877.. ...
Strength training
"Physiological Biomarkers for Predicting Performance".. *^ Sell, Aaron; Cosmides, Leda; Tooby, John; Sznycer, Daniel; Rueden, ... "Non-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club". Osteoporos Int. 22 (11): 2769-88. doi ...
Մասնակից:ArmArtificial Intelligence/Ավազարկղ - Վիքիպեդիա՝ ազատ հանրագիտարան
Biomarkers[խմբագրել , խմբագրել կոդը]. A 2013 review concluded moderate-quality evidence exists to support use of the ... Therapeutic interventions in sepsis: current and anticipated pharmacological agents»։ British Journal of Pharmacology 171 (22 ... to try to identify biomarkers and drug targets for intervention.[110] ...
Flavonoid
Biological and pharmacological activities which have been investigated in greater depth are described below. Research at the ... Chukwumah Y, Walker LT, Verghese M (2009). "Peanut skin color: a biomarker for total polyphenolic content and antioxidative ... Flavonoids have been shown to have a wide range of biological and pharmacological activities in in vitro studies. Examples ...
Alzheimer's disease
A blood test for circulatory miRNA and inflammatory biomarkers is a potential alternative indicator.[296] ... Trends in Pharmacological Sciences. 12 (10): 383-88. doi:10.1016/0165-6147(91)90609-V. PMID 1763432.. ... "Effectiveness and acceptability of non-pharmacological interventions to reduce wandering in dementia: a systematic review". ... "Exploring Biomarkers for Alzheimer's Disease". Journal of Clinical and Diagnostic Research (Review). 10 (7): KE01-06. doi ...
Cardiovascular Disease in COPD: Evidences from Epidemiology, Genetics, Bio-Markers, Animal Models, Clinical Studies &...
Cardiovascular Disease in COPD: Evidences from Epidemiology, Genetics, Bio-Markers, Animal Models, Clinical Studies & ... Pharmacological treatments. Executive Summary. The National Heart, Lung, and Blood Institute convened a meeting of ... Cardiovascular Disease in COPD: Evidences from Epidemiology, Genetics, Bio-Markers, Animal Models, Clinical Studies & ...
Application # 2017/0191057. RNA EDITING BIOMARKERS FOR DIAGNOSIS, PHARMACOLOGICAL SCREENING AND
PROGNOSTICATION IN CANCER ...
RNA EDITING BIOMARKERS FOR DIAGNOSIS, PHARMACOLOGICAL SCREENING AND PROGNOSTICATION IN CANCER Abstract. Compositions and ... 21, 26, 27). These data show that RESSq-PCR for these and other RNA editing biomarkers can form the basis of screening methods ... 14--shows the selection of CSC-specific RNA editing biomarkers used for RESSq-PCR assay primer design. [0040] FIG. 15--shows ... This will also allow one to use edited miRNA signature, instead of a general miRNA profile as disease biomarkers. Moreover, the ...
Leicester Research Archive: Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological...
Pharmacological targets and biomarkers | Centre de Biophysique Moléculaire, CNRS - Orléans
Accueil,Cell biology, Molecular Targets and innovative therapies,Research teams,Research,,Pharmacological targets and ... identify novel biomarkers and (3) screen for small synthetic and natural libraries to identify compounds unable to modulate ... to identify potent pharmacological tools and novel biological targets involved in cancer and neurological disorders. We are ...
DNA damage and aberrant crypt foci as putative biomarkers to evaluate
Pharmacological Inhibition and Activation of the Ca Activated Cl Channel TMEM16A. | Physician's Weekly
Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β-glucuronidase in tumors | Cancer Gene Therapy
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report...
High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting | Nature Biomedical Engineering
Catalase Up-Regulation | GreenMedInfo | Pharmacological Action
Dietary strawberries selectively increase antioxidant biomarkers in obese adults with elevated serum lipids.Dec 31, 2015. ... Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation. Additional Keywords : Plant ... Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation. Additional Keywords : Anti- ... Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation. Additional Keywords : Gene ...
Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance - Tabular View...
Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine | SpringerLink
Despite intense investigation, no specific pharmacological treatment for ARDS has been shown to affect the mortality, even ... Septic shock biomarkers: ProCESS study. A large biomarker study of 1341 individuals enrolled in the Protocolized Care of Early ... Biomarkers. In ARDS biomarkers have promise in diagnosis and stratification, assessment of prognosis and to evaluate response ... MicroRNAs as biomarkers of acute lung injury. Ann Transl Med. 2018;6:34.PubMedPubMedCentralCrossRefGoogle Scholar ...
Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18) - Full Text...
Other: Pharmacological Study Correlative Studies. Other: Laboratory Biomarker Analysis Correlative Studies. Biological: Anti- ... Biological: Anti-LAG-3 Monoclonal Antibody BMS 986016 Biological: Anti-PD-1 Other: Pharmacological Study Other: Laboratory ... To explore potential associations between biomarker measures and anti-tumor activity by analyzing markers of inflammation, ... on biomarkers in peripheral blood, including the T cell compartments, and serum proteins (cytokines and other immune modulators ...
Anti-LAG-3 or Urelumab Alone and in Combination With Nivolumab in Treating Patients With Recurrent Glioblastoma - Full Text...
Endocrine Disruptor | GreenMedInfo | Adverse Pharmacological Action
Search of: bavituximab - List Results - ClinicalTrials.gov
Physio-pharmacological Investigations About the Anti-inflammatory and Antinociceptive Efficacy of (+)-Limonene Epoxide |...
Inflammatory mediators as biomarkers in brain disorders. Inflammation 37: 639-648.PubMedGoogle Scholar ... Physio-pharmacological Investigations About the Anti-inflammatory and Antinociceptive Efficacy of (+)-Limonene Epoxide. ... Regulatory T cell levels and cytokine production in active non-infectious uveitis: in vitro effects of pharmacological ...
Hypothermia News, Research
Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers
... Antiviral Res. 2010 Dec;88 Suppl 1:S10-8. ... Biomarkers, Pharmacological * Dosage Forms * Drug Evaluation, Preclinical * Drug and Narcotic Control * Endpoint Determination ... Incorporation of new models, assays and biomarkers has expanded our ability to understand the mechanisms of action underlying ...
Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children
Other oxidative stress biomarkers such as malondialdehyde, reduced glutathione, total antioxidant capacity, catalase activity, ... Pharmacological Research, 2020. DOI:10.1016/j.phrs.2020.104918 [3] The Contribution of Fluoride to the Pathogenesis of Eye ... "Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children" written by Omar M. E. Abdel-Salam, ... Biomarkers in autism spectrum disorders: Current progress. Clinica Chimica Acta, 2020. DOI:10.1016/j.cca.2019.12.009 ...
PA4303: Current Topics in Pharmacological Research - Catalogue of Courses
To enhance understanding of the use of biomarkers in pharmacology and toxicology. ... To develop advanced understanding of the processes surrounding pharmacological drug design and molecular targeting using ... PA4303: CURRENT TOPICS IN PHARMACOLOGICAL RESEARCH (2019-2020). Last modified: 25 Sep 2019 09:58 ...
Medical Research - Association ELA
2 biomarkers for the treatment of leukodystrophies. Manager: A. PUJOL, Fundació Privada Institut dInvestigacio Biomedica de ... 3 pharmacological strategies to treat leukodystrophies. Responsibles for : H. WERNER, Max Planck Gesellschaft zur Foerderung ... Objective: To determine, in biological samples collected from patients, markers (biomarkers) of the disease or its severity in ...
Glaucoma | GreenMedInfo | Disease | Natural Medicine | Alternative
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, ... Mindfulness meditation reduces intraocular pressure, lowers stress biomarkers and modulates gene expression in glaucoma.Nov 30 ... Pharmacological Actions : Antihypertensive Agents, Antioxidants, Neuroprotective Agents. Additional Keywords : Antihypertensive ... Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, ...
Interdisciplinary Safety Evaluation and Quantitative Safety Monitoring: Introduction to a Series of Papers.
Alzheimer's Disease Research | Charles River
Pharmacological MRI. Biomarkers identification. *Immunohistochemistry of amyloid plaques, phosphorylated Tau, GFAP, Iba1 and ... In CVN mice, the motor deficit is reproducible but is used more as a biomarker endpoint and less to assess efficacy. The ... Either aged or scopolamine-treated animals (to impair cognition) are used for touchscreen and biomarker assessment of ... and biomarker measurement using immunohistochemical staining at just 5 months of age. ...
Nicholas Michael Dalesio, M.D.
Molecular Medicine Reports
Open Access Articles ::: Current Pharmaceutical Biotechnology
Glutamatergic Deficits in Schizophrenia - Biomarkers and Pharmacological Interventions within the Ketamine Model , 2018; 19(4 ... Role of MicroRNA 21 in Mesenchymal Stem Cell (MSC) Differentiation: A Powerful Biomarker in MSCs Derived Cells. , 2015; 16(1): ... He is one of the author of the patent "Nanoconstructs with pharmacological activity" (n° WO2014013473-A1), and co-founder of ... Global Cell Proteome Profiling, Phospho-signaling and Quantitative Proteomics for Identification of New Biomarkers in Acute ...
Current Pharmaceutical Biotechnology, Volume 19 - Number 4
Glutamatergic Deficits in Schizophrenia - Biomarkers and Pharmacological Interventions within the Ketamine Model , 19(4): 293 ... Glutamatergic Deficits in Schizophrenia - Biomarkers and Pharmacological Interventions within the Ketamine Model ... He is one of the author of the patent "Nanoconstructs with pharmacological activity" (n° WO2014013473-A1), and co-founder of ...
InhibitionInterventionsBiologicalMolecularClinicalRepresents a pharmacologicalTumorPutative biomarkersPrognosticNeurodegenerative DiseasesSerumInflammatoryPredictiveInterventionTargetsTherapeuticDIAGNOSISCANCERSubstancesFMRIStudyOutcomeOutcomesTreatmentDrugProteinNeurologicalProcessesDiseaseCognitivePatientsInhibitorPhMRIResearchTreatments
Inhibition5
- Pharmacological Inhibition and Activation of the Ca Activated Cl Channel TMEM16A. (physiciansweekly.com)
- We will test the ability of pharmacological general PHD inhibition to prevent iron and redox dysregulation, mitochondrial dysfunction and midbrain dopaminergic cell loss associated with a chronic, age-related pre-clinical model of PD recently established by our laboratory, inducible dopaminergic glutathione depletion (Chinta et al. (michaeljfox.org)
- Pharmacological inhibition of JAK2 with tyrphostin B42 (AG490) attenuated STAT3 activation and GFAP expression in the MPTP model. (cdc.gov)
- S. Alban, " Pharmacological Strategies for Inhibition of Thrombin Activity", Current Pharmaceutical Design (2008) 14: 1152. (eurekaselect.com)
- TRPV4 inhibition also diminished renal IR-induced increase in AKI biomarkers. (clinsci.org)
Interventions4
- This Funding Opportunity Announcement (FOA) invites applications that propose to develop and implement Phase I or II clinical trials of promising pharmacological and non-pharmacological interventions in individuals with age-related cognitive decline and in individuals with Alzheimer's disease (AD) across the spectrum from pre-symptomatic to more severe stages of disease, as well as to stimulate studies to enhance trial design and methods. (nih.gov)
- Pharmacological interventions for hypertensive emergencies. (biomedsearch.com)
- The Biomarker and Intervention Development for Childhood-Onset Mental Disorders Branch supports research leading to the development of novel, mechanism-based treatments, and preventive interventions for childhood-onset mental disorders. (nih.gov)
- The programs within this branch support research to develop novel cognitive, behavioral, psychosocial, pharmacological, and device-based interventions. (nih.gov)
Biological4
- We have developed expertise in a large variety of screening methods (BRET, TR-FRET, Alpha screen, RILES) to identify potent pharmacological tools and novel biological targets involved in cancer and neurological disorders. (cnrs-orleans.fr)
- He examines this central question from both psychological and biological perspectives, particularly using pharmacological methods. (edu.au)
- A biological marker, commonly known as a biomarker, measures and evaluates biological and pathogenic processes. (openpr.com)
- Since the development of alcohol-related diseases is a complex multi-step process involving many biological pathways as well as environmental factors, NIAAA is especially interested in the pattern-based molecular fingerprints which consist of multiple genes, RNAs, proteins, metabolites, or combination of them for novel biomarkers with high sensitivity, specificity, and accuracy. (nih.gov)
Molecular5
- Biomarker panels have potential applications in molecular phenotyping for identifying patients at risk of developing ARDS, diagnosis of ARDS, risk stratification and monitoring. (springer.com)
- The increasing evidence for heterogeneity of asthma, the growing emphasis on asthma subphenotypes, including molecular phenotypes identified by omics technologies, and their possible implications for different asthma severity and progression and therapeutic response, are changing the paradigm of treating patients with asthma only based on classification of their disease severity to a pharmacological strategy more focused on the individual asthmatic patient. (frontiersin.org)
- Both techniques rely on molecular detection: optofluidic microscopy relies on molecular biomarkers, and scanning ion conductance microscopy on functional imaging of molecular structures. (europa.eu)
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites small business grant applications to use genomic, proteomic, and/or metabolomic technologies to identify molecular fingerprints as novel biomarkers for alcohol exposure and alcohol induced organ damage. (nih.gov)
- The course aims to develop an understanding of pharmacological targeting and molecular toxicology at an advanced level. (abdn.ac.uk)
Clinical3
- Many researchers have now focused their efforts on developing biomarkers for depression-tests for aspects of a patient's physiology that can predict a clinical outcome. (dana.org)
- The pharmacological MRI (phMRI) technique is being increasingly used in both pre-clinical and clinical models to investigate pharmacological effects on task-free brain function. (semanticscholar.org)
- The branch also supports the identification of reliable and valid biomarkers useful for stratification of research participants in clinical trials or for use as objective predictors or indicators of treatment response (surrogate endpoints). (nih.gov)
Represents a pharmacological1
- Targeting TLR4 signaling therefore represents a pharmacological strategy to prevent intractable fibrosis. (frontiersin.org)
Tumor4
- To explore potential associations between biomarker measures and anti-tumor activity by analyzing markers of inflammation, immune activation, host tumor growth factors, and tumor-derived proteins in the pre-treatment and on-treatment setting. (clinicaltrials.gov)
- Here we review estrogen receptor-related putative breast cancer biomarkers, including those of putative breast cancer stem cells, a minor population of estrogen receptor negative tumor cells that retain the stem cell property of self renewal. (mdpi.com)
- We analyzed PAC cultivation and pharmacological perturbation of tumor tissue slices from patients. (fraunhofer.de)
- Conclusion: The PAC system facilitates the cultivation and pharmacological perturbation of tumor tissue slices in the context of the complex tumor microenvironment. (fraunhofer.de)
Putative biomarkers2
- DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis. (greenmedinfo.com)
- Sang, Q.-X. Putative Biomarkers and Targets of Estrogen Receptor Negative Human Breast Cancer. (mdpi.com)
Prognostic2
- NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer. (physiciansweekly.com)
- Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments. (europa.eu)
Neurodegenerative Diseases1
- 3) identification of potential targets and biomarkers for neurological/neurodegenerative diseases. (stanford.edu)
Serum3
- Dietary strawberries selectively increase antioxidant biomarkers in obese adults with elevated serum lipids. (greenmedinfo.com)
- I. To assess the pharmacodynamic effects of anti-LAG-3 antibody (BMS-986016), anti-CD137 antibody (BMS- 663513), and/or anti-PD-1 antibody (BMS-936558) on biomarkers in peripheral blood, including the T cell compartments, and serum proteins (cytokines and other immune modulators). (clinicaltrials.gov)
- Serum levels of high sensitivity C-reactive protein (hs-CRP) concentration were determined by chemiluminescence and serum levels of all other biomarkers by ELISA. (scielo.br)
Inflammatory3
- Two subphenotypes of ARDS have been identified on the basis of blood biomarkers: hypo-inflammatory and hyper-inflammatory. (springer.com)
- This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. (hindawi.com)
- It concerns a Phase 2, randomized, placebo-controlled, 5-way cross-over pharmacological study, with a classical inhalation combination of an anti-inflammatory corticoid (ICS) - beclomethasone- and a long-acting beta-agonist (LABA) - formoterol. (sgs.com)
Predictive1
- Our results suggest RAC1 P29S status may offer a predictive biomarker for RAF inhibitor resistance in melanoma patients, where it should be evaluated clinically. (nih.gov)
Intervention3
- It also measures pharmacological responses to a therapeutic intervention. (openpr.com)
- Objectives Development of digital biomarkers to predict treatment response to a digital behavioural intervention. (bmj.com)
- Digital biomarkers have potential to improve treatment outcomes in a digital behavioural intervention. (bmj.com)
Targets1
- Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers. (nih.gov)
Therapeutic1
- Conclusions Machine learning was used to transform data from a digital therapeutic into digital biomarkers that predicted treatment response in individual participants. (bmj.com)
DIAGNOSIS2
- He is one of the author of the patent "Nanoconstructs with pharmacological activity" (n° WO2014013473-A1), and co-founder of the spin-off company inTHEna srl, aiming to design and development of molecules, nanostructures and technologies for biomedical studies and diagnosis, prevention and therapy of human and animal diseases. (benthamscience.com)
- Her2/neu, CA15.3, estrogen receptor (ER), progesterone receptor (PR), and cytokeratins are biomarkers that have been approved by the Food and Drug Administration for disease diagnosis, prognosis, and therapy selection. (mdpi.com)
CANCER4
- A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer. (yale.edu)
- The structural and functional complexity of protein biomarkers and the heterogeneity of the breast cancer pathology present challenges to the scientific community. (mdpi.com)
- PURPOSE: This phase I trial is studying biomarker-guided fluorouracil in treating patients with colorectal cancer receiving combination chemotherapy. (bioportfolio.com)
- We conclude that NAC has the potential to impact upon tobacco smoke carcinogenicity in humans because it can modulate certain cancer-associated biomarkers in specific organs. (aacrjournals.org)
Substances1
- Drugs such as opium, alcohol, and certain plants have been used for millennia by humans to ease suffering or change awareness, but until the modern scientific era knowledge of how the substances actually worked was quite limited, most pharmacological knowledge being more a series of observation than a coherent model. (wikipedia.org)
FMRI1
- Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry. (semanticscholar.org)
Study2
- The aim of the present study was to characterize the systemic response of biomarkers known to be involved in the vascular response to coronary stenting and determine if oral sirolimus has any effect on the behavior of these biomarkers. (scielo.br)
- In the present study, we show that pharmacological activation of TRPV4 channels constricted preglomerular microvessels and elicited renal hypoperfusion in neonatal pigs. (clinsci.org)
Outcome2
- Outcome trials are needed to determine whether improvement in biomarkers translates into a reduction in cardiovascular events in patients with type 2 diabetes. (diabetesjournals.org)
- In this chapter, we review the recent findings on the detrimental cross‐talk between sepsis and AKI and the identification of new, early biomarkers and targeted therapies aimed at improving the outcome of these critically ill patients. (biomedcentral.com)
Outcomes2
- Outcomes for COPD pharmacological trials: from lung function to biomarkers. (semanticscholar.org)
- Proof-of-concept biomarkers demonstrated good power to predict treatment outcomes despite the small size of the training dataset. (bmj.com)
Treatment7
- Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area. (springer.com)
- Chapter "Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities" is available open access under a via link.springer.com. (springer.com)
- Pharmacological treatment of asthma is going toward a personalized approach. (frontiersin.org)
- Asthma control is the primary goal of pharmacological treatment of patients with asthma. (frontiersin.org)
- There are few available pharmacological therapies for treatment of renal disease [ 4 ]. (hindawi.com)
- National and international guidelines for the pharmacological treatment of IPF recommend 2 antifibrotic drugs, nintedanib and pirfenidone. (archbronconeumol.org)
- In addition, selective pharmacological and genetic tools have been developed both to explore alternative metabolic routes and to produce eCB‐based drugs as therapeutics for the prevention/treatment of a variety of diseases. (els.net)
Drug3
- Incorporation of new models, assays and biomarkers has expanded our ability to understand the mechanisms of action underlying microbicide toxicity and efficacy, enabling a more rational selection of drug and formulation candidates. (nih.gov)
- The CRC's Imaging Unit with high-end large-scale equipment will allow the following unique opportunities: for example, identification of MR-based biomarkers to assess the effect of drugs (surrogate parameters), establishment of normal levels and reference ranges for MRI-based biomarkers, evaluation of the most relevant MRI sequences for drug monitoring in outpatient care. (fraunhofer.de)
- To investigate the drug effects common biomarkers (Ki67, γH2AX, HIF1α, GMNN, cleaved caspase-3) were analyzed in IHC staining. (fraunhofer.de)
Protein1
- The following biomarkers were evaluated: high sensitivity C-reactive protein (hs-CRP), soluble interleukin-2 receptor alpha (IL-2sRα), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9), tissue inhibitor of MMP-1 (TIMP-1), intercellular adhesion molecule-1 (ICAM-1), and P-selectin. (scielo.br)
Neurological1
- Ligands and effectors associated with activation of this pathway may serve as early 'biomarkers' of neurological/neurotoxic hazards. (cdc.gov)
Processes1
- Biomarkers serve as indicators of pathological, physiological, or pharmacological processes. (mdpi.com)
Disease1
- IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease. (europa.eu)
Cognitive2
- Validated using multiple endpoints including cognitive testing, measurement of the levels of soluble and insoluble beta amyloid, and biomarker measurement using immunohistochemical staining at just 5 months of age. (criver.com)
- This includes validating new and existing nutritional products that may have a pharmacological profile useful in cognitive enhancement - for example, the bacopa extract CDRI08. (edu.au)
Patients1
- For pharmacological perturbation experiments culture medium was supplemented with 13 μM Cisplatin and constantly delivered to slices for 72 h, mimicking the in vivo situation in patients. (fraunhofer.de)
Inhibitor2
- Biomarkers of particular interest have included interleukins (IL-6 and IL-8), interferon gamma (IFN-γ), surfactant proteins (SPD and SPB), von Willebrand factor antigen, angiopoietin 1/2 and plasminogen activator inhibitor-1 (PAI-1). (springer.com)
- Cytokines and haemostatic biomarkers remained associated with nephropathy after adjustments (use of statin, acetylsalicylic acid, angiotensin converting enzyme inhibitor, and angiotensin antagonist). (hindawi.com)
PhMRI1
- Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, induces a strong phMRI response and represents a promising pharmacological model to investigate the role of glutamatergic abnormalities in psychiatric symptomatology. (semanticscholar.org)
Research2
- The market dominance of North America is attributed to the high concentration of pharmaceutical company and their research and development (R&D) center in this region, also the aging population and rising healthcare expenditure in North America is fueling the demand of biomarker in this region. (openpr.com)
- NIAAA is also interested in research applications to develop or improve the technologies or methodologies in these areas that would benefit the biomarker discovery for alcohol-induced organ damage. (nih.gov)
Treatments2
- The finding could lead to new pharmacological treatments for depression and could change the way schools deal with the condition. (newscientist.com)
- Teenagers could be screened for the biomarker and those at risk provided with targeted treatments. (newscientist.com)