Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.
A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.
The application of TOXICOLOGY knowledge to questions of law.
The recording of images in three-dimensional form on a photographic film by exposing it to a laser beam reflected from the object under study.
A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
A technique for analysis of the chemical composition of molecules. A substance is bombarded with monochromatic ELECTRONS. Some of the electrons passing through the specimen will lose energy when they ionize inner shell electrons of the atoms in the specimen. The energy loss is element dependent. Analysis of the energy loss spectrum reveals the elemental composition of a specimen. ENERGY-FILTERED TRANSMISSION ELECTRON MICROSCOPY is a type of electron energy loss spectroscopy carried out in electron microscopes specially outfitted to analyze the spectrum of electron energy loss.
The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.
Centers for acquiring, characterizing, and storing organs or tissue for future use.
Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.
Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Fluorescence microscopy utilizing multiple low-energy photons to produce the excitation event of the fluorophore. Multiphoton microscopes have a simplified optical path in the emission side due to the lack of an emission pinhole, which is necessary with normal confocal microscopes. Ultimately this allows spatial isolation of the excitation event, enabling deeper imaging into optically thick tissue, while restricting photobleaching and phototoxicity to the area being imaged.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Methods of creating machines and devices.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Centers for storing various parts of the eye for future use.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Centers for collecting, characterizing and storing human blood.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The study of the origin, structure, development, growth, function, genetics, and reproduction of organisms which inhabit the OCEANS AND SEAS.
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.
A publication issued at stated, more or less regular, intervals.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). The sandfly genera Phlebotomus and Lutzomyia are the vectors.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Exclusive legal rights or privileges applied to inventions, plants, etc.
Elements of limited time intervals, contributing to particular results or situations.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
The privacy of information and its protection against unauthorized disclosure.
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.
The activities and endeavors of the public health services in a community on any level.

Accessory DNA in the genomes of representatives of the Escherichia coli reference collection. (1/285)

Different strains of the Escherichia coli reference collection (ECOR) differ widely in chromosomal size. To analyze the nature of the differential gene pool carried by different strains, we have followed an approach in which random amplified polymorphic DNA (RAPD) was used to generate several PCR fragments. Those present in some but not all the strains were screened by hybridization to assess their distribution throughout the ECOR collection. Thirteen fragments with various degrees of occurrence were sequenced. Three of them corresponded to RAPD markers of widespread distribution. Of these, two were housekeeping genes shown by hybridization to be present in all the E. coli strains and in Salmonella enterica LT2; the third fragment contained a paralogous copy of dnaK with widespread, but not global, distribution. The other 10 RAPD markers were found in only a few strains. However, hybridization results demonstrated that four of them were actually present in a large selection of the ECOR collection (between 42 and 97% of the strains); three of these fragments contained open reading frames associated with phages or plasmids known in E. coli K-12. The remaining six fragments were present in only between one and four strains; of these, four fragments showed no similarity to any sequence in the databases, and the other two had low but significant similarity to a protein involved in the Klebsiella capsule synthesis and to RNA helicases of archaeal genomes, respectively. Their percent GC, dinucleotide content, and codon adaptation index suggested an exogenous origin by horizontal transfer. These results can be interpreted as reflecting the presence of a large pool of strain-specific genes, whose origin could be outside the species boundaries.  (+info)

Intraspecific diversity of the 23S rRNA gene and the spacer region downstream in Escherichia coli. (2/285)

The molecular microevolution of the 23S rRNA gene (rrl) plus the spacer downstream has been studied by sequencing of different operons from some representative strains of the Escherichia coli ECOR collection. The rrl gene was fully sequenced in six strains showing a total of 67 polymorphic sites, a level of variation per nucleotide similar to that found for the 16S rRNA gene (rrs) in a previous study. The size of the gene was highly conserved (2902 to 2905 nucleotides). Most polymorphic sites were clustered in five secondary-structure helices. Those regions in a large number of operons were sequenced, and several variations were found. Sequences of the same helix from two different strains were often widely divergent, and no intermediate forms existed. Intercistronic variability was detected, although it seemed to be lower than for the rrs gene. The presence of two characteristic sequences was determined by PCR analysis throughout all of the strains of the ECOR collection, and some correlations with the multilocus enzyme electrophoresis clusters were detected. The mode of variation of the rrl gene seems to be quite similar to that of the rrs gene. Homogenization of the gene families and transfer of sequences from different clonal lines could explain this pattern of variation detected; perhaps these factors are more relevant to evolution than single mutation. The spacer region between the 23S and 5S rRNA genes exhibited a highly polymorphic region, particularly at the 3' end.  (+info)

Mouse ENU mutagenesis. (3/285)

The progress of human genome sequencing is driving genetic approaches to define gene function. Strategies such as gene traps and chemical mutagenesis will soon generate a large mutant mouse resource. Point mutations induced by N -ethyl- N -nitrosourea (ENU) provide a unique mutant resource because they: (i) reflect the consequences of single gene change independent of position effects; (ii) provide a fine-structure dissection of protein function; (iii) display a range of mutant effects from complete or partial loss of function to exaggerated function; and (iv) discover gene functions in an unbiased manner. Phenotype-driven ENU screens in the mouse are emphasizing relevance to human clinical disease by targeting cardiology, physiology, neurology, immunity, hematopoiesis and mammalian development. Such approaches are extremely powerful in understanding complex human diseases and traits: the base-pair changes may accurately model base changes found in human diseases, and subtle mutant alleles in a standard genetic background provide the ability to analyze the consequences of compound genotypes. Ongoing mouse ENU mutagenesis experiments are generating a treasure trove of new mutations to allow an in-depth study of a single gene, a chromosomal region or a biological system.  (+info)

Distribution of intervening sequences in the genes for 23S rRNA and rRNA fragmentation among strains of the Salmonella reference collection B (SARB) and SARC sets. (4/285)

Intervening sequences (IVSs) occur sporadically in several bacterial genera in the genes for 23S rRNA at relatively conserved locations. They are cleaved after transcription and lead to the presence of fragmented rRNA, which is incorporated into the ribosomes without religation but is nevertheless functional. The fragmentation of rRNA and the number of IVSs in all 72 strains of the Salmonella Reference Collection B set and 16 strains of the Salmonella Reference Collection C set, which have been established on the basis of multilocus enzyme electrophoresis (MLEE), were analyzed in the present study. Fragmentation of 23S rRNA was restricted to conserved cleavage sites located at bp 550 (helix 25) and bp 1170 (helix 45), locations where IVSs have been reported. Random cleavage at sites where IVSs could not be detected was not seen. Uncleaved IVSs were not detected in any case; thus, the IVSs invariably led to rRNA fragmentation, indicating a strong selection for maintenance of RNase III cleavage sites. The distribution of the number of IVSs carried by the different strains in the seven rrl genes is diverse, and the pattern of IVS possession could not be related to the MLEE pattern among the various Salmonella strains tested; this indicates that the IVSs are frequently exchanged between strains by lateral transfer. All eight subspecies of the genus Salmonella, including subspecies V represented by Salmonella bongori, have IVSs in both helix 25 and helix 45; this indicates that IVSs entered the genus after its divergence from Escherichia coli (more than 100 million years ago) but before separation of the genus Salmonella into many forms or that they were in the ancestor but have been lost from Escherichia.  (+info)

Differences in genotypes of Helicobacter pylori from different human populations. (5/285)

DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric pathogen. Five types of deletion, insertion, and substitution motifs were found at the right end of the H. pylori cag pathogenicity island. Of the three most common motifs, type I predominated in Spaniards, native Peruvians, and Guatemalan Ladinos (mixed Amerindian-European ancestry) and also in native Africans and U.S. residents; type II predominated among Japanese and Chinese; and type III predominated in Indians from Calcutta. Sequences in the cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native Peruvians were also more like those from Spaniards than those from Asians. These indications of relatedness of Latin American and Spanish strains, despite the closer genetic relatedness of Amerindian and Asian people themselves, lead us to suggest that H. pylori may have been brought to the New World by European conquerors and colonists about 500 years ago. This thinking, in turn, suggests that H. pylori infection might have become widespread in people quite recently in human evolution.  (+info)

Cancer gene discovery using digital differential display. (6/285)

The Cancer Gene Anatomy Project database of the National Cancer Institute has thousands of expressed sequences, both known and novel, in the form of expressed sequence tags (ESTs). These ESTs, derived from diverse normal and tumor cDNA libraries, offer an attractive starting point for cancer gene discovery. Using a data-mining tool called Digital Differential Display (DDD) from the Cancer Gene Anatomy Project database, ESTs from six different solid tumor types (breast, colon, lung, ovary, pancreas, and prostate) were analyzed for differential expression. An electronic expression profile and chromosomal map position of these hits were generated from the Unigene database. The hits were categorized into major classes of genes including ribosomal proteins, enzymes, cell surface molecules, secretory proteins, adhesion molecules, and immunoglobulins and were found to be differentially expressed in these tumorderived libraries. Genes known to be up-regulated in prostate, breast, and pancreatic carcinomas were discovered by DDD, demonstrating the utility of this technique. Two hundred known genes and 500 novel sequences were discovered to be differentially expressed in these select tumor-derived libraries. Test genes were validated for expression specificity by reverse transcription-PCR, providing a proof of concept for gene discovery by DDD. A comprehensive database of hits can be accessed at http:// www.fau.edu/cmbb/publications/cancergenes. htm. This solid tumor DDD database should facilitate target identification for cancer diagnostics and therapeutics.  (+info)

exl, an exchangeable genetic island in Neisseria meningitidis. (7/285)

The genetic structure and evolution of a novel exchangeable meningococcal genomic island was defined for the important human pathogen Neisseria meningitidis. In 125 meningococcal strains tested, one of three unrelated nucleotide sequences, designated exl (exchangeable locus), was found between a gene required for heme utilization, hemO, and col, encoding a putative Escherichia coli collagenase homologue. The 5' boundary of each exl cassette was the stop codon of hemO, whereas the 3' boundary was delineated by a 33-bp repeat containing neisserial uptake sequences located downstream of col. One of the three alternative exl cassettes contained the meningococcal hemoglobin receptor gene, hmbR (exl3). In other meningococcal strains, hmbR was absent from the genome and was replaced by either a nucleotide sequence containing a novel open reading frame, exl2, or a cassette containing exl3. The proteins encoded by exl2 and exl3 had no significant amino acid homology to HmbR but contained six motifs that are also present in the lipoprotein components of the lactoferrin (LbpB), transferrin (TbpB), and hemoglobin-haptoglobin (HpuA) uptake systems. To determine the evolutionary relationships among meningococci carrying hmbR, exl2, or exl3, isolates representing 92 electrophoretic types were examined. hmbR was found throughout the population structure of N. meningitidis (genetic distance, >0.425), whereas exl2 and exl3 were found in clonal groups at genetic distances of <0.2. The commensal neisserial species were identified as reservoirs for all of the exl cassettes found in meningococci. The structure of these cassettes and their correlation with clonal groups emphasize the extensive gene pool and frequent horizontal DNA transfer events that contribute to the evolution and virulence of N. meningitidis.  (+info)

Recent events and observations pertaining to smallpox virus destruction in 2002. (8/285)

To destroy all remaining stocks of variola virus on or before 31 December 2002 seems an even more compelling goal today than it did in 1999, when the 52d World Health Assembly authorized temporary retention of remaining stocks to facilitate the possible development of (1) a more attenuated, less reactogenic smallpox vaccine and (2) an antiviral drug that could be used in treatment of patients with smallpox. We believe the deadline established in 1999 should be adhered to, given the potential outcomes of present research. Although verification that every country will have destroyed its stock of virus is impossible, it is reasonable to assume that the risk of a smallpox virus release would be diminished were the World Health Assembly to call on each country to destroy its stocks of smallpox virus and to state that any person, laboratory, or country found to have virus after date x would be guilty of a crime against humanity.  (+info)

TY - JOUR. T1 - Cohort profile. T2 - Design and methods in the eye and vision consortium of UK Biobank. AU - UK Biobank Eye and Vision Consortium. AU - Chua, Sharon Yu Lin. AU - Thomas, Dhanes. AU - Allen, Naomi. AU - Lotery, Andrew. AU - Desai, Parul. AU - Patel, Praveen. AU - Muthy, Zaynah. AU - Sudlow, Cathie. AU - Peto, Tunde. AU - Khaw, Peng Tee. AU - Foster, Paul J.. AU - Trucco, Emanuele. PY - 2019/2/21. Y1 - 2019/2/21. N2 - Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, ...
This fact sheet provides information for NHS, Health Professionals Follow-up Study (HPFS), and Growing Up Today Study (GUTS) participants with biospecimens in the Brigham and Womens Hospital (BWH) / Harvard Cohorts Biorepository. Overview Thank you for participating in the BWH/Harvard Cohorts Biorepository. This fact sheet provides more information about the biorepository.
UK Biobank aims to assess the relevance of a very wide range of health-related outcomes. It is a large prospective study to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. During 2006-2010, UK Biobank conducted its recruitment phase of more than 500,000 participants who gave their consent, answered questions, had physical measurements and gave samples (blood, urine and saliva) at a Baseline assessment visit. Follow-up of their health is now being conducted through medical and other health-related records. Access systems have been developed to facilitate use of the UK Biobank Resource by bona fide researchers for health-related research that is in the public interest ...
Swiss Biobanking Platform just released two pre-analytical datasets (liquid & tissue) for consultation that Swiss biobanks are recommended to use.. The datasets were developed by a group including experts from all five university hospitals in Switzerland. They emphasise that documenting biological factors that are expected to have an influence on sample quality is absolutely essential.. Please click here for more information on the Liquid Working Group. Please click here for more information on the Tissue Working Group. Based on International Good Biobanking Practices, CEN specifications, the Standard PREanalytical code released by ISBER (SPREC), and Swiss practice, the datasets cover the different biobanking processes from sampling to retrieval and propose a common language to describe pre-analytical attributes of samples. They also include some health-related data required for initial searches of suitable samples. Finally, they cover fields related to quality in biobanking processes.. The ...
Biospecimens collected by the CONCERT Biobank are made available to researchers on the provision that use of specimens are for scientifically valid and ethically approved research projects.. Researcher access entails search facilities which allow for researchers to search biospecimen type and availability stored in the CONCERT Biobank using a link from the CONCERT TCRC website to the Biobanks database, which is currently still under development. All biospecimens and information are stored securely and de-identified however they are re-identifiable to CONCERT Biobank personnel who have signed confidentially agreements. Search facilities on the database protect all identifiable information of the participant.. Currently, as the CONCERT Biobank is still in the progress of developing and implementing its database, researchers can request the use of biospecimens by contacting the CONCERT Biobank manager through the Ingham Institute for Applied Medical Researchs Biobank page, ...
The goal of personalized medicine has ushered in the transition from empirical medicine to molecular medicine. Thus during research, biobanks are key infrastructures for biomedical R& D because at one time or another, these biospecimens have been stored in a biobank. Well-annotated biospecimens and their associated clinical data accelerate translational and clinical research discoveries. However, high-throughput molecular sequencing and increased biosample variety have introduced significant informatics challenges for biobanking infrastructures. Meanwhile, the lack of high-quality biospecimens both stalls projects and limits research advances. Cambridge Healthtech Institutes Ninth International Leaders in Biobanking Congress addresses biospecimen science, management, and applications, bringing together biomedical and biopharmaceutical researchers, regulators, biorepository managers and practitioners to investigate the best strategies for effective use of biospecimens within todays cutting-edge
How Biorepositories Can Help Your Research. Tatiana Foroud, Ph.D. Department of Medical and Molecular Genetics. Overview. Sample collection for genetic studies Typical DNA applications for genetic studies Results from several ongoing studies. Collecting Samples for Genetic Studies. Slideshow 6743902 by dominica-ronnie
In this webinar, we briefly discussed the regulatory considerations for biorepositories including the following: When HHS, FDA and HIPAA regulations apply, Whe…
Given the importance of results discovered by biorepositories and their implications for an individuals health care choices, I believe that the individual has the right to receive his results despite their lack of verification. However, this right to receive results should be premised upon the individuals explicit consent to receive his results, and upon the understanding that by receiving these results, the burden of their verification shifts from the biorepostory to the individual.. Biorepositories are collections of biospecimens that are tested and analyzed for scientific purposes. The testing performed on these biospecimens has become the basis for development of various molecular tests, which is becoming critical for the shift toward personalized medicine. Therefore, as technology advances, the quality and management of biorepositories is becoming more important. This is especially critical for the return of accurate patient data resulting from biospecimen analysis. However, managing and ...
Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK
Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK
UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3-4 dedicated UK Biobank imaging centres that will acquire and
1. Dekkers IA, Jansen PR, Lamb HJ. Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study. Radiology. 2019 Apr 23:181012.. 2. Hwang LD, Lin C, Gharahkhani P, Cuellar-Partida G, Ong JS, An Gordon SD, Zhu G, MacGregor S, Lawlor DA, Breslin PAS, Wright MJ, Martin NG, Reed DR. New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. Am J Clin Nutr. 2019 Apr 21. pii: nqz043.. 3. Machado-Fragua MD, Struijk EA, Ballesteros JM, Ortolá R, Rodriguez Artalejo F, Lopez-Garcia E. Habitual coffee consumption and risk of falls in 2 European cohorts of older adults. Am J Clin Nutr. 2019 Apr 21. pii: nqy369.. 4. Hajna S, White T, Panter J, Brage S, Wijndaele K, Woodcock J, Ogilvie D, Imamura F, Griffin SJ. Driving status, travel modes and accelerometer assessed physical activity in younger, middle-aged and older adults: a prospective study of 90 810 UK Biobank participants. Int J Epidemiol. 2019 Apr 19. pii: ...
From managing the storage and maintenance of annotated specimen data to following the chain of custody and making determinations about a sample quickly and accurately, a biobanking LIMS requires standard features to meet the needs of the community.. At LabVantage, for example, we designed our biobanking LIMS to address these concerns using a centralized LIMS for efficient, accurate, and secure tracking of biobank samples and consents.. Want to learn more? Read our latest article in Genetic Engineering & Biotechnology News.. Interested in learning how a LIMS built specifically for Biobanking can better support your organization by tearing down your data silos and maximizing the insights you draw from your biobank data? Contact us today.. ...
Biobanking strategies and regulative approaches in the EU: recent perspectives Katharina Beier,1 Christian Lenk2 1Department of Medical Ethics and History of Medicine, University Medical Center Göttingen, Göttingen, Germany; 2Institute of the History, Philosophy, and Ethics of Medicine, Ulm University, Ulm, Germany Abstract: Biobanks, ie, systematic collections of human biological materials and associated clinical and lifestyle data, provide an indispensable infrastructure for modern research. Although biobank research takes place on a global scale, there is no internationally binding framework for its ethical and legal regulation yet. A better understanding of existing regulative approaches is an important prerequisite for its ethical and legal harmonization and, thus, for improving the interoperability of biobank-based research in the future. This review focuses on biobanking strategies, regulative approaches, and recent developments in Europe. Specifically, we discuss selected ethical and
Biobank consent models – are we moving toward increased participant engagement in biobanking? Berge Solberg, Kristin Solum Steinsbekk Department of Public Health and General Practice, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Abstract: Engagement, involvement, and active participation are buzzwords used in today's ethical debate on research biobanking. There are a variety of context-sensitive governance frameworks for research biobanks. However, many biobanks, especially large-scale population-based ones, seem to endorse a framework of broad consent, participation with minimal or no ongoing engagement, and no return of results. An alternative vision of involvement and active participation in this type of research has become increasingly visible in the literature. The problem, seen from the biobankers' perspective, is that the alternative vision might be costly, cumbersome, and risky, while the prevailing system for governance will maximize the scientific
There are several characteristics of COLS that differentiate it from existing repositories.. First, most biobanks are created to study a given disease and consist of samples from ill patients. In contrast, COLS is disease inclusive by design. Many participants will be well when they enter the study; although, some will have chronic diseases at the outset. COLS will continue collecting samples for a decade. As people become ill that data will be captured in the bank. Therefore, both rare and common diseases will be represented over time because of the size of the cohort.. Second, COLS is omics exhaustive; that is blood and urine will be collected and stored in a way that preserves multiple molecules. Most biobanks are designed to preserve only one molecule, most commonly DNA. Previously, the dogma was that the genome was the key to understanding health and disease. We now understand that most diseases cannot be explained solely by ones genome, but instead by dynamic changes in molecules such as ...
CTSI Biorepository Biospecimen collection, processing and storage. Stored biospecimens can be used by any researcher with IRB approved protocols. Prospective biospecimen collection to fulfill investigator needs for IRB approved protocols. Storage for biospecimens collected by investigators. Stored biospecimens belong solely to the investigator. Oversight of the release of biospecimens from the UF Department of Pathology for other IRB approved research protocols. Pathology services including those provided by the Molecular Pathology Core and confirmation of diagnosis by a board certified pathologist upon request. The UF CTSI is supported in part by NIH awards UL1 TR000064, KL2 TR000065 and TL1 TR000066 One of two Hamilton 80 C automated sample management systems (Robotic freezers ). The biorepository also has eight Forma Thermo Scientific 80 C Freezers with back up CO 2 and sensaphone alarm systems including back up storage space, centrifuge for basic bodily fluid processing, QiaCube for small ...
How many clinics in Texas market stem cell procedures? What interventions do they promote? How many adult stem cell banks are located in Texas? How do they advertise their services?. There does not appear to be a comprehensive record of stem cell banks and clinics marketing stem cell procedures within the state of Texas. I am therefore trying to determine how many stem cell banks and clinics marketing stem cells in Texas can be found using an approach that a patient or customer might take when searching the Internet. In an effort to locate such businesses, I used Google search engine and entered such terms as stem cells Texas, stem cell clinics Texas, cosmetic surgery stem cell Texas, orthopedic surgery stem cell clinic Texas, and anti-aging stem cells Texas. In total, I found twenty businesses marketing what they describe as stem cell procedures as well as three stem cell banks. During my search I also noticed and recorded a spa marketing plant stem cells and a dentist who ...
The overall goal of this project is to identify strategies to reduce lung cancer incidence and mortality. Using a high-risk occupational cohort, our specific objectives are 1) to establish a biologic specimen bank and data bank that can be used for the validation and refinement of potential early markers of lung cancer, and 2) to establish a cohort for the study of environmental (including dietary) and genetic risk factors for lung cancer.. Lung cancer is the leading cause of death from malignant neoplasms in the United States and in many countries around the world. Potential strategies to reduce the incidence and mortality of lung cancer include new methods of early detection and identification and alteration of etiologic factors.. The Yunnan Tin Corporation (YTC), located in Yunnan Province in southern China, is a large, nonferrous-metals industry, formed in 1883 and nationalized after the establishment of the Peoples Republic in 1949. It is involved principally in the production of tin from ...
The EDRN Colorectal and Pancreatic Neoplasm Virtual Biorepository with a tangible translational biomedical informatics infrastructure facilitates translational research. The data query tool acts as a central source and provides a mechanism for researchers to efficiently query clinically annotated da …
OriGene has developed comprehensive human cancer and normal tissue products from its biorepository of over 140,000 high-quality human tissues. This includes TissueScan cDNA arrays for qPCR, total RNA, genomic DNA, protein lysates, TMAs, FFPE and Frozen Tissue Sections and Blocks, and IHC Control Slides.
Moffitt Cancer Center and M2Gen have been awarded a contract from the National Institutes of Healths National Heart, Lung, and Blood Institute to serve as the Central Laboratory and Biorepository for The National Myelodysplastic Syndromes Natural History Study (The National MDS Study).
ProteoGenex has a centralized biorepository of over 200,000 human clinical specimens in a wide variety of formats (FFPE & Frozen Tissues, Serum/Plasma, etc)
The Massachusetts General Hospital Cardiovascular Biorepository (CVBio) advances cardiovascular research by providing patient data and blood samples to help researchers understand how genes and other factors contribute to heart disease.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: National Gene Vector Biorepository and Coordinating Center (P40) RFA-RR-07-002. NCRR
The Biorepository and Pathology CoRE is a multi-dimensional service group providing consultation and technical support for the translational and basic science groups across MSHS.
Rogena, J., Kihara, A. and Kemp, S. 2014. Monitoring ILRIs biorepository. Poster presented at the 50th Anniversary Celebration and Annual Scientific Conference for the Society of Low Temperature Biology, London, UK, 8-10 October 2014 ...
Biobanking 2018 will bring together the worlds leading experts in biorepositories, policy makers, and scientific actors to strengthen knowledge in biobanking as well as explore future advances in the field of biosampling for precision medicine, drug development and health research.
Biorepositories are highly complex research facilities with expert staff to process, store, characterize and secure biological specimens and their corresponding clinical information. The Biopathology Center at Nationwide Childrens Hospital, the hospitals long-standing biorepository, has received accreditation from the College of American Pathologists, confirming that the biorepository operates to ensure that high-quality biospecimens and related data are available for the purpose of supporting cutting-edge medical research.
The aim of this thesis is to investigate the relationship between individuals and society in the context of healthcare and medical research, more specifically concerning the rights and duties of individuals in regard to biobank-based research. My starting point is that we all have a strong vested interest in improved healthcare, and therefore the possibilities to conduct important research should be optimized. In the first article, I investigate whether individual results from research using samples in large-scale biobanks should be returned. I conclude that there is good reason not to implement such policies, and instead to allocate available resources to pursuing medical advances. In the second article, I compare consent for using stored samples in research with consent for organ donation, whereby many countries have adopted opt-out strategies in order to increase the number of organs available. I claim that the default position should be changed in biobank research as well, i.e. it should be ...
Carolinas HealthCare System recently created a BioSpecimen Repository on its Mint Hill campus, which will ultimately enhance researchers understanding of how to more effectively treat a broad range of diseases. Carol J. Farhangfar, PhD, MBA, Assistant Vice President of Carolinas HealthCare Systems Tissue Procurement and Levine Cancer Institutes Translational Research, is overseeing the development of the Repository and discusses its significance for providers and patients. Q: Why was the Biospecimen Repository created at CHS, and how will it enhance our research efforts? The BioSpecimen Repository (BSR) was created at CHS to provide a comprehensive, enterprise-wide system to collect, process, store, and distribute high quality biospecimens for clinical and translational research. It will enhance the capabilities of dedicated CHS investigators and enable the evolution of CHS into a nationally recognized clinical service provider that can leverage tissues and other biospecimens to help us ...
Biobanks are an important resource for the research and development of cell and gene therapies, but biobanking requires the careful consideration of ethics and patient privacy, and carries issues around lack of inclusion of ethnic minorities. Furthermore, biobanks for cell therapies are still in their infancy in terms of potential to have a significant impact on healthcare: large, clinical-grade banks of cells, whether induced pluripotent stem cells or other, with diverse genetic backgrounds will be needed for widespread clinical application of cellular therapies. This channel includes content around all these different aspects, including the latest news and opinion, and top peer-reviewed articles.
Our DNA Banking and Storage service stores your DNA for up to 15 years, preserving your DNA for identification or to protect your estate.
Abstract Finland has enacted a Biobank Act that will come into force on 1 September 2013. Finland is regarded as a highly successful environment for medical research using population samples and data for many reasons. One of the rationales behind the new legislation was to solve the problems due to the overly strict informed consent doctrine hindering access to old samples and data and asking for multi-purpose consents. Yet although consent is the primary justification to use biobank samples and data, the Biobank Act allows asking for a consent for several unspecified future research purposes. The guiding principles of the Biobank Act are promotion of trust, equal access to data and samples, protection of privacy, acceleration of innovation activities, and bringing biobank activities under public scrutiny. To the authors knowledge, this is the first
OBJECTIVE: To estimate the effect of BMI on cause-specific hospital admissions and costs in men and women is not well understood, and this studys aim is to address this. METHODS: For 451,320 men and women aged 40 years or older recruited into the UK Biobank, followed up for 6 years on average, this study estimated annual rates and costs (at 2016 UK prices) of hospital admissions, overall and by diagnostic category (using International Classification of Diseases, Tenth Revision chapters), in relation to BMI. RESULTS: Among those who were never smokers, a 2-kg/m2 higher BMI (above 20 kg/m2 ) was associated with a 6.2% (99% CI: 5.3% to 7.2%) higher admission rate and an 8.6% (99% CI: 7.3% to 10.0%) higher annual cost in men and with a 5.7% (99% CI: 4.9% to 6.6%) higher admission rate and an 8.4% (99% CI: 7.5% to 9.3%) higher annual cost in women. Higher BMI was associated with higher admission rates and costs for many types of health conditions, particularly for endocrine, skin, and musculoskeletal
We investigated the association between genetic risk of stroke, lifestyle, and incident risk of stroke in 306 473 people within the population based UK Biobank study. Risk of incident stroke was 35% higher among those at high genetic risk compared with those at low genetic risk, and these associations were independent of lifestyle profile. Furthermore, an unfavourable lifestyle was associated with a 66% increased risk of incident stroke compared with a favourable lifestyle, and this increased risk was present within any genetic risk category. A high genetic risk combined with an unfavourable lifestyle profile was associated with a more than twofold increased risk of stroke compared with a low genetic risk and a favourable lifestyle.. The present study provides further support that common genetic variants are implicated in the development of stroke. Our findings showing that a polygenic risk score is associated with incident stroke is in line with both clinical and population based ...
Context: UK Biobank is a prospective study of half a million subjects, almost all aged 40-69 years, identified in 22 centres across the UK during 2006-2010. Objective: A healthy lifestyle has been described as better than any pill, and no side effects [5]. We therefore examined the relationships between healthy behaviours: low alcohol intake, non-smoking, healthy BMI, physical activity and a healthy diet, and the risk of all cancers, colon, breast and prostate cancers in a large dataset. Method: Data on lifestyle behaviours were provided by 343,150 subjects, and height and weight were measured at recruitment. 14,285 subjects were diagnosed with cancer during a median of 5.1 years of follow-up. Results: Compared with subjects who followed none or a single healthy behaviour, a healthy lifestyle based on all five behaviours was associated with a reduction of about one-third in incident cancer (hazard ratio [HR] 0.68; 95% confidence intervals [CI] 0.63-0.74). Colorectal cancer was reduced in subjects
Background: Policy makers are being encouraged to specifically target sugar intake in order to combat obesity. We examined the extent to which sugar, relative to other macronutrients, was associated with adiposity. Methods: We used baseline data from UK Biobank to examine the associations between energy intake (total and individual macronutrients) and adiposity [body mass index (BMI), percentage body fat and waist circumference]. Linear regression models were conducted univariately and adjusted for age, sex, ethnicity and physical activity. Results: Among 132 479 participants, 66.3% of men and 51.8% of women were overweight/obese. There was a weak correlation (r = 0.24) between energy from sugar and fat; 13% of those in the highest quintile for sugar were in the lowest for fat, and vice versa. Compared with normal BMI, obese participants had 11.5% higher total energy intake and 14.6%, 13.8%, 9.5% and 4.7% higher intake from fat, protein, starch and sugar, respectively. Hence, the proportion of ...
This is a full description of the quality control procedure undertaken and the derived files produced by the MRC-IEU associated with the full UK Biobank (July 2017) genetic data ...
Healthy living and cancer: evidence from UK Biobank Peter C Elwood1, Alex Whitmarsh1, John Gallacher2, Anthony Bayer1, Richard Adams3, Luke Heslop1
Health-care research relies largely on human materials stored in highly specialised biorepositories. Medical translational research on tissues can be performed using a variety of resources in distinct situations. The best known is the secondary use of pathology archives where paraffin-embedded tissues are stored for diagnostic reasons. Another is collecting and storing frozen material obtained from leftover surgical diagnosis. Such residual tissues can either be used directly in research projects or used in the context of a clinical trial with new interventional medicinal products. The latter can make the regulations governing the use of these materials for medical research much more complicated. The use of residual materials is very distinct from biobanking projects for which tissue is specifically collected. This article describes the consequences of using residual human material from different sources in distinct situations and why signed informed consent is not always the preferred choice of ...
Purpose: Biospecimens (e.g. tissues, bloods, fluids) are critical for translational cancer research to generate the necessary knowledge to guide implementation of precision medicine. Rising demand and the need for higher quality biospecimens are already evident. Methods: The recent increase in requirement for biospecimen complexity in terms of linked biospecimen types, multiple preservation formats, and longitudinal data was explored by assessing trends in cancer research publications from 2000 to 2014. Results: A Pubmed search shows that there has been an increase in both raw numbers and the relative proportion (adjusted for total numbers of papers in each period) of the subgroups of papers typically associated with the use of biospecimens and both dense treatment and/or outcomes data and multiple biospecimen formats. Conclusions: Increasing biospecimen complexity is a largely unrecognized and new pressure on cancer research biobanks. New approaches to cancer biospecimen resources are needed ...
Trans-Hit Bio is the worldwide biospecimen access CRO with the most extensive collection capability for biospecimens and clinical samples through an unrivaled worldwide partnered-network of state-of-the-art academic biorepositories and clinical sites.. ...
Trans-Hit Bio is the worldwide biospecimen access CRO with the most extensive collection capability for biospecimens and clinical samples through an unrivaled worldwide partnered-network of state-of-the-art academic biorepositories and clinical sites.. ...
Background: Coronary heart disease (CHD) poses a major health burden in the Gulf countries. Knowledge of novel genetic and proteomic markers of CHD will provide more precise estimates of risk while defining the pathways important in individual patients, revealing new targets for intervention, and ultimately enabling an individualized approach to care. We describe design of a biorepository with linkage to medical records to facilitate discovery of biomarkers for CHD. Methods: The goal of the Qatar Cardiovascular Biorepository (QCBio) is to archive plasma and DNA of 1000 Qatari patients with CHD and 1000 age, gender, and ethnicity-matched controls who have no history of CHD. Cases will include patients needing percutaneous intervention for symptomatic CHD or admitted with an acute coronary syndrome (myocardial infarction or unstable angina). Controls will be identified from the blood bank as adults who have no history of CHD. Relevant risk factors and comorbid conditions will be ascertained by electronic
In 2012, the College accredited RUDCR through its Biorepository Accreditation Program, making the operation at Rutgers one of the first in the world to earn this designation.. The program is intended to improve and validate the quality of biospecimens and biorepositories. It focuses on standardizing and improving the collection, processing, storage, and distribution of biospecimens, along with computerizing associated information. The program also is intended to ensure the quality of human specimens (e.g., blood, serum, saliva, tissue) and the genetic materials derived from them (e.g., DNA, RNA).. Were extremely pleased by this strong validation of our shared commitment to the highest levels of quality and service to the biomedical research community, said Jay A. Tischfield, Founder and Chief Executive Officer of RUCDR, Duncan and Nancy Macmillan Professor of Genetics, and Director of the Human Genetics Institute of New Jersey. There are thousands of biorepositories in the world, with a wide ...
US Biolab is a global biobank that have access to a diverse range of human biospecimens in various disease states to meet researchers research needs. Our biobank contains more than 500,000 huamn tissue (FFPE and fresh frozen), tissue array, serum, plasma, whole blood, DNA, and RNA samples. Our team collaborates with the major clinical and research center in the USA, Europe, and Asia on developing collection protocols that are approved by local IRBs and Ethical Committees and that comply with international and local regulations and guidelines. Our customers are major pharmaceutical and biotechnology companies as well as academic and government research organizations. Our samples are handled consistently according to validated protocol accommodate the quality requirements of most research methods used in the drug discovery and development process.. ...
TY - JOUR. T1 - Contrast-free microscopic assessment of glioblastoma bioposy specimens prior to biobanking. AU - Georges, Joseph. AU - Zehri, Aqib. AU - Carlson, Elizabeth. AU - Nichols, Joshua. AU - Mooney, Michael A.. AU - Martirosyan, Nikolay L.. AU - Ghaffari, Layla. AU - Kalani, M. Yashar S.. AU - Eschbacher, Jennifer. AU - Feuerstein, Burt. AU - Anderson, Trent. AU - Preul, Mark C.. AU - Van Keuren-Jensen, Kendall. AU - Nakaji, Peter. PY - 2014/2/26. Y1 - 2014/2/26. N2 - Glioblastoma is the most common primary brain tumor with a median 12- to 15-month patient survival. Improving patient survival involves better understanding the biological mechanisms of glioblastoma tumorigenesis and seeking targeted molecular therapies. Central to furthering these advances is the collection and storage of surgical biopsies (biobanking) for research. This paper addresses an imaging modality, confocal reflectance microscopy (CRM), for safely screening glioblastoma biopsy samples prior to biobanking to ...
Disposal of samples This issue was not addressed in Resolution CNS 347/05, although there are normative documents issued by National Agency for Sanitary Vigilance (ANVISA, Brasilia, Brazil) and the National Environmental Council (CONAMA, Brasilia, Brazil). The ACCHB and BNT-INCA currently discard samples due to inadequate quality. Samples may also be retrieved for additional diagnostic purposes or by consent-granted withdrawal. The possibility of bankruptcy also needs to be considered. It is illegal to sell biological human samples in Brazil, and biobanks like ACCHB and BNT-INCA are usually established with grant support from state, federal, and international funding agencies. However, as with biorepositories, such grants are limited in duration. In this case, both the Ministry of Health Ordinance No. 2201 and the Resolution CNS 441/11 state that, provided that the samples are adequate for research, their transfer to another institution should be considered, and destruction-in a manner not ...
The 2017 American College of Cardiology/American Heart Association guideline defines hypertension as a blood pressure ≥130/80 mm Hg, whereas the 2018 European Society of Cardiology (ESC) and 2019 National Institute for Health and Care Excellence (NICE) guidelines use a ≥140/90 mm Hg threshold. Our objective was to study the associations between isolated diastolic hypertension (IDH), diagnosed using these 2 blood pressure thresholds, and cardiovascular disease (CVD) in a large cohort of UK adults. We analyzed data from UK Biobank, which enrolled participants between 2006 and 2010 with follow-up through March 2019. We excluded persons with systolic hypertension or baseline CVD. We defined incident CVD as a composite of nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. We used Cox regression to quantify associations between IDH and CVD, as well as the individual outcomes included in the composite outcome. We studied 151 831 participants with normal systolic blood ...
BACKGROUND: With an estimated one billion hypertension cases worldwide, the role of the built environment in its prevention and control is still uncertain. The present study aims to examine the associations between neighbourhood walkability and hypertension in a large and diverse population-based cohort. MATERIALS AND METHODS: We examined the association between neighbourhood walkability and blood pressure outcomes for N = 429,334 participants drawn from the UK Biobank and aged 38-73 years. Neighbourhood walkability was objectively modelled from detailed building footprint-level data within multi-scale functional neighbourhoods (1.0-, 1.5- and 2.0-kilometer street catchments of geocoded dwelling). A series of linear and modified Poisson regression models were employed to examine the association between walkability and outcomes of diastolic blood pressure (DBP in mmHg), systolic blood pressure (SBP in mmHg) and prevalent hypertension adjusting for socio-demographic, lifestyle and related physical
Results 12 015 and 10 344 participants died during a median of 18.5 and 7.0 years of follow-up in the HUNT Study and UK Biobank, respectively. Linear mendelian randomisation analyses indicated an overall positive association between genetically predicted BMI and the risk of all cause mortality. An increase of 1 unit in genetically predicted BMI led to a 5% (95% confidence interval 1% to 8%) higher risk of mortality in overweight participants (BMI 25.0-29.9) and a 9% (4% to 14%) higher risk of mortality in obese participants (BMI ≥30.0) but a 34% (16% to 48%) lower risk in underweight (BMI ,18.5) and a 14% (−1% to 27%) lower risk in low normal weight participants (BMI 18.5-19.9). Non-linear mendelian randomisation indicated a J shaped relation between genetically predicted BMI and the risk of all cause mortality, with the lowest risk at a BMI of around 22-25 for the overall sample. Subgroup analyses by smoking status, however, suggested an always-increasing relation of BMI with mortality in ...
Note. This blog post should be read on a laptop. With smaller screens, some of the tables cannot be correctly formatted. Introduction: what has been found The UK Biobank is a large-scale biomedical database that includes genetc data on 500,000 UK citizens (Sudlow, C et al. 2015). Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is among the…
EPIC (European Prospective Investigation into Cancer and Nutrition) is a similar study that was started in 1992 and involves 520,000 men and women mostly between 35 and 70 years old from ten European countries. Participants are recontacted every three to five years. It is specifically designed to study the respective roles of diet and genes in the development of cancer.[11][39] In 1996 a private company deCODE genetics Inc. planned to obtain biobank samples, health and genealogical data from the whole population of Iceland - then about 270,000 people.[40] The company hoped to use the data to identify genes associated with diseases[41] and use that information to develop new drugs. deCODE genetics obtained data and DNA samples on 140,000 Icelanders[42] but filed for Chapter 11 bankruptcy in 2009[43] and as of January 2015 its systems and databanks had been spun off to another company NextCODE Health,[44] owned by WuXi PharmaTech.[45] In 2015, the Chief Executive of deCODE said that with the DNA ...
A capillary electrophoresis coupled to tandem mass spectrometry (CE-MS/MS) has been used to make a qualitative determination of hercynine-the main precursor of l-ergothioneine biosynthesis-in some key human biological specimens, such as urine, whole blood, plasma, and saliva. From semiquantitative analysis results, the highest concentrations of hercynine were detected in saliva and whole blood, whereas much lower concentrations were measured in urine and plasma. Whole blood was the biological matrix with the highest concentration of l-ergothioneine followed by plasma, saliva, and urine. The antioxidant effects attributed to l-ergothioneine, along with its peculiar antioxidant mechanism, offer a possible explanation for the presence of the hercynine, as well as its concentration, in the considered biological matrices ...
Dr. Katharine Hagerman and Lisa Harvey-Duren share their experience with the Stanford Biobank. Donating the tissue or other clinical specimens of a loved one will help advance treatments for myotonic dystrophy and provides hope that our family and friends will have a better future.
Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimers and Parkinsons Disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme - Neurodegenerative Disease Research (JPND), that aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimers disease (AD) and Parkinsons disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized preanalytical procedures (SOP) and stored at Integrated BioBank of Luxembourg (IBBL). The virtual biobank provides an overview of available CSF, plasma, serum, and ...
Introduction: Biobanks are repositories that store biospecimens and health information for research. Healthy control samples from diverse racial/ethnic groups must be represented in biobanks to better examine genetic and environmental risk factors for diseases such as cancer. However, the general public appears to be skeptical about the purpose of these repositories, with minority populations being less likely to donate samples. The Ponce School of Medicine-Moffitt Cancer Center Partnership conducted a study to examine communication channels for delivering biobanking education to healthy Hispanics. The purpose of this article is to describe the successful strategies used during the recruitment process.. Methods: The Outreach Core recruited community members (n=254) in Ponce, Puerto Rico and Tampa, Florida using a variety of in-person and media-based approaches. In-person strategies involved staffing booths at community events targeted to Hispanics such as health fairs, American Cancer Society ...
An overview is given of serum and urine prostate cancer markers that are currently under investigation and subsequently the P-Mark project is introduced. There are many markers showing promise to overcome the limitations of prostate specific antigen (PSA). Eventually, these markers should be able to increase the specificity in diagnosis, differentiate between harmless and aggressive disease and identify progression towards androgen independence at an early stage. In the P-Mark project, several recently developed, promising markers will be evaluated using clinically well-defined biorepositories. Following successful evaluation, these markers will be validated on a sample set derived from two large, European, prostate cancer studies and used for the identification of special risk groups in the general population. In addition, novel markers will be identified in the same biorepositories by different mass spectrometry techniques.
Stem cell bank. Labelled vials of embryonic stem cells at a stem cell bank, a place for storing the stem cells (by freezing) until they are needed. Stem cells are precursor cells from which all the bodys specialized tissue cells develop. Stem cell specialization can be initiated in the laboratory by the use of chemical growth factors. Stem cell research involves trying to use stem cells to repair or replace diseased tissues or organs. All the cells in young embryos are stem cells, and these cells were obtained from embryos that died of natural causes. Photographed at the Besta Neurological Institute, Milan, Italy. - Stock Image G442/0140
Last year the MCB Cell Bank obtained an authorization (PZ-T.04061.4.2015.ASI) from the Minister of Health for harvesting, processing, storing and distribution of human skin cells - keratinocytes, fibroblasts and melanocytes, human mezenchymal stem cells isolated from bone marrow and fat tissue, human chondrocytes isolated from cartilaginous tissue, human muscle cells, extracellular adipose matrix and we obtained also scientific recommendations on classification of our advanced therapy medicinal products from EMA which are required to obtain the approval of Main Pharmaceutical Inspectorate for production of the advanced therapy medicinal products with hospital exemption HE-ATMP. This year the MCB Cell Bank obtained the consent of the Main Pharmaceutical Inspectorate (GIF-IW-400/0490/01/460/UA2/15) for production of the advanced therapy medicinal products with hospital exemption HE-ATMP which include all mentioned above. ...
The Prostate Cancer Pathology Resource Network Award was established in 2009 to provide support for the development of a prostate cancer biorepository consortium that will facilitate the collection, processing, annotation, storage, and distribution of high-quality human prostate cancer biospecimens through a collaborative network across multiple institutions. The award is designed to support a biorepository that will enable the prostate cancer research community to address multiple areas of research such as biomarkers, therapy, genetics, and tumor biology to move toward the PCRP vision of conquering prostate cancer. FY13 Prostate Cancer Pathology Resource Network Awards. ...
Home , Papers , Implementation of the Uniformed Services University Pain Registry Biobank: A Military and Veteran Population Focused Biobank and Registry. ...
The study of multifactorial diseases, such as vitiligo, requires analysis of complex interplay of symptoms, treatments and outcomes across a large number of people. Population surveys and biobanks are indispensable research tools, required for downstream therapy development. Even small collections of biosamples may be extremely precious for researcher in academic institution or biopharma company.. Until recently, vitiligo researchers were generally limited to conducting studies on patient samples they could acquire themselves. When the Foundation started there were no centralized biological database along with the pre-existing body of the clinical management or the historical study data, which is required in order to proceed with the development of specific therapies. We have run a special investigation study to determine whether VRF shall establish its own biobank.. Then the projects leadership crafted a careful strategy for vitiligo biobank development, with special attention paid to the ...
The study of multifactorial diseases, such as vitiligo, requires analysis of complex interplay of symptoms, treatments and outcomes across a large number of people. Population surveys and biobanks are indispensable research tools, required for downstream therapy development. Even small collections of biosamples may be extremely precious for researcher in academic institution or biopharma company.. Until recently, vitiligo researchers were generally limited to conducting studies on patient samples they could acquire themselves. When the Foundation started there were no centralized biological database along with the pre-existing body of the clinical management or the historical study data, which is required in order to proceed with the development of specific therapies. We have run a special investigation study to determine whether VRF shall establish its own biobank.. Then the projects leadership crafted a careful strategy for vitiligo biobank development, with special attention paid to the ...
Mitochondrial diseases comprise a group of relatively rare (~1 in 5000 adults) but very serious genetic disorders. Mitochondria are often called the powerhouses of the cell because they provide the energy our cells need to live. Mitochondria have their own DNA (mtDNA), but they also rely on DNA from the nucleus (nDNA). Mitochondrial diseases are caused by mutations in either mitochondrial or nuclear DNA that result in poorly functioning mitochondria. This can cause a variety of symptoms including muscle weakness, seizures, mental retardation, dementia, hearing loss, blindness, strokes, diabetes, and premature death. Most mitochondrial diseases are progressive, and we are unable to cure most of these diseases with currently available treatments.. Research into mitochondrial diseases has been hampered by the low frequency of these disorders and by under-diagnosis by clinicians. This has hindered patient recruitment for research studies and clinical trials. The North American Mitochondrial ...
The National Ecological Observatory Network is a major facility fully funded by the National Science Foundation. Any opinions, findings and conclusions or recommendations expressed in this material do not necessarily reflect the views of the National Science Foundation. ...
The National Ecological Observatory Network is a major facility fully funded by the National Science Foundation. Any opinions, findings and conclusions or recommendations expressed in this material do not necessarily reflect the views of the National Science Foundation. ...
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IBBL (Integrated Biobank of Luxembourg) provides biospecimen related services and biobanking infrastructure for applied medical research.
Have you had a blood sample taken for research purposes? If so, youre not alone. Hundreds of pulmonary hypertension (PH) patients in Sheffield are taking part in a world-leading research programme aimed at bringing about new treatments for the disease.. The Pulmonary Hypertension Research Biobank is a growing store of blood products which are being analysed by scientists to better understand the basic biological workings underlying the development of PH.. The collection, held at the University of Sheffield Medical School and the Royal Hallamshire Hospital, includes 900 samples taken from 400 patients since it was set up in 2009. Where the study is unique is that it gathers samples from patients from before their diagnosis and over the longer-term as they undergo therapies.. Dr Allan Lawrie, who leads the talented team behind the research, believes it will lead to breakthroughs in treatment in the future as tools the scientists use for analysis become ever more sophisticated.. The Biobank was ...
A national repository of biological samples from traumatic brain injury (TBIs) patients at the University of Pittsburgh Department of Neurological Surgery. This biorepository supports the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study, a multi-center initiative funded by the National Institutes of Health (NIH).
The biological samples collected in biobanks are a resource with significant research potential, but may also be subject to various ethical and deontological conflicts.. Policies and practices about storage and use of residual newborn screening specimens vary considerably. Several studies show, and denounce, not only significant differences in national policies, but also fragmentations with in federal States (e.g. Australia, United States) [1, 2] and different regional practices within countries (e.g. Italy) [3]. In the European Union, although binding regulations give a common framework to Member States, national regulations, policies and practices vary as regards length of storage, possibility of research use of deidentified samples, parents information sheets, and so on. Moreover, many samples now stored in biobanks were collected years ago, in situations lacking standardization and in contexts where an awareness of the need to meticulously handle information and obtain consent was not yet ...
A new Michigan State University study, published in the Journal of the American Medical Association, indicates that most people are willing to donate just knowing that their contribution is going toward research. But, when specific scenarios are brought into the equation, that willingness changes.. We really wanted to document the concerns people have that may affect their desire to donate, said Tom Tomlinson, director of MSUs Center for Ethics and Humanities. Biobanks are becoming more and more important to health research, so its important to understand these concerns and how transparent these facilities need to be in the research they support.. Tomlinson, who led the study with co-author Raymond De Vries, a bioethics professor at the University of Michigan, surveyed nearly 1,600 people within the United States and found 68 percent were willing to donate using a blanket consent method. This approach gives a biobank one-time permission to use a donation for whatever research they deem ...
Bipolar Disorder Biobank at Mayo Clinic: Collects biological samples to establish and research Bipolar Type I and II disorder causes and treatment.
The Partners Biobank has released a second batch of genotype data to the research community at Partners HealthCare. Genotype data for nearly 9,500 subjects is now available for free. Imputed data will be available in a few weeks for a fee. The Partners Biobank will genotype another ~15,500 subjects over the next two years, releasing data every six months. The subjects are
The LBIH Biobank has been specifically created to provide SMEs and academic researchers with high quality biosamples, data, and analytical services. We house a vast array of biosamples, both cancerous and non-cancerous, and have the ability to collect bespoke samples and data to suit the needs of researchers. We have access to a wide variety of samples types including, but not limited to, frozen tissue, fresh tissue, blood products, urine and FFPE blocks. The LBIH Biobank can further process these into a number of products such as DNA, frozen sections, and cryo-aliquots. In order to offer a one-stop shop for research, we offer additional services such as IHC, next generation sequencing,TMA creation, and project management for studies and projects, to include storage of trial samples. ...
Bipolar Disorder Biobank at Mayo Clinic: Contact the biobank for questions about bipolar disorder or participant and researcher inquires.
Background: The Qatar Biobank aims to collect extensive lifestyle, clinical, and biological information from up to 60,000 men and women Qatari nationals and long-term residents (individuals living in the country for ≥15 years) aged ≥18 years (approximately one-fifth of all Qatari citizens), to follow up these same individuals over the long term to record any subsequent disease, and hence to study the causes and progression of disease, and disease burden, in the Qatari population. Methods: Between the 11th-December-2012 and 20th-February-2014, 1209 participants were recruited into the pilot study of the Qatar Biobank. At recruitment, extensive phenotype information was collected from each participant, including information/measurements of socio-demographic factors, prevalent health conditions, diet, lifestyle, anthropometry, body composition, bone health, cognitive function, grip strength, retinal imaging, total body dual energy X-ray absorptiometry, and measurements of cardiovascular and ...
Ex vivo microscopy is an emerging set of imaging modalities intended to enable histological imaging of whole tissue specimens at the point-of-procedure. Ex vivo microscopy holds much promise for enabling rapid verification of cancer biospecimen quantity and quality at the time of specimen acquisition. Two areas in which such technologies would be extremely helpful to pathologists are in 1) screening of biopsies collected during a biopsy procedure with the aim of providing guidance for collection of additional tissues, and 2) non-destructively assessing and verifying cancer content in biospecimens collected for banking and downstream molecular analysis. In prostate cancer diagnosis, for example, 70-80% of the 1 million biopsies collected for diagnosis each year are ultimately found to be benign on permanent histopathology review. For tissue banking, the major limiting pre- analytical factor for downstream molecular and genetic analysis is the amount of cancerous tissue present in the banked ...
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The Report Biobanking: Developing Smart, Sustainable and Ethically Compliant Biorepositories for the Future provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports. ...
The Biorepository Core serves as a resource to process, track, store, retrieve and prepare biological samples for the research projects within the Center for Molecular Epidemiology.. Critical to successful molecular epidemiologic research are high quality, accessible human biological samples. Automated specimen processing and freezer storage systems are being developed to provide specialized expertise to the proposed projects for the five-year COBRE award, and ultimately produce a sustainable institutional and regional resource Core for Molecular Epidemiology.. Read More ». ...
Tissue samples were obtained using the GTEx standard operating procedures for informed consent and tissue collection, in conjunction with the National Cancer Institute Biorepositories and Biospecimen. All tissue specimens were reviewed by pathologists to characterize and verify organ source. Images from stained tissue samples can be viewed via the NCI histopathology viewer. The Qiagen PAXgene non-formalin tissue preservation product was used to stabilize tissue specimens without cross-linking biomolecules.. RNA-seq was performed by the GTEx Laboratory, Data Analysis and Coordinating Center (LDACC) at the Broad Institute. The Illumina TruSeq protocol was used to create an unstranded polyA+ library sequenced on the Illumina HiSeq 2000 platform to produce 76-bp paired end reads at a depth averaging 50M aligned reads per sample. Sequence reads were aligned to the hg19/GRCh37 human genome using Tophat v1.4.1 assisted by the GENCODE v19 transcriptome definition. Gene annotations were produced by ...
Tissue samples were obtained using the GTEx standard operating procedures for informed consent and tissue collection, in conjunction with the National Cancer Institute Biorepositories and Biospecimen. All tissue specimens were reviewed by pathologists to characterize and verify organ source. Images from stained tissue samples can be viewed via the NCI histopathology viewer. The Qiagen PAXgene non-formalin tissue preservation product was used to stabilize tissue specimens without cross-linking biomolecules.. RNA-seq was performed by the GTEx Laboratory, Data Analysis and Coordinating Center (LDACC) at the Broad Institute. The Illumina TruSeq protocol was used to create an unstranded polyA+ library sequenced on the Illumina HiSeq 2000 platform to produce 76-bp paired end reads at a depth averaging 50M aligned reads per sample. Sequence reads were aligned to the hg19/GRCh37 human genome using Tophat v1.4.1 assisted by the GENCODE v19 transcriptome definition. Gene annotations were produced by ...

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  • Biodiversity, or biological diversity, is the variety of all life forms.Sum total of all the variety of living organisms on earth constitute biodiversity. (pscnotes.com)
  • Convention on Biological Diversity :-The objectives of the CBD are the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits arising from commercial and other utilization of genetic resources. (pscnotes.com)
  • The FitzPatrick Institute of African Ornithology aims to "To promote and undertake scientific studies involving birds, and contribute to the practice affecting the maintenance of biological diversity and the sustained use of biological resources. (adu.org.za)
  • Often with bare banks and a hard (like rocky) bottom. (adu.org.za)
  • Often with bare banks, rocks and a hard (rocky) and/or soft (muddy) bottom, probably especially pools in stream beds. (uct.ac.za)
  • The mangrove trees have breathing roots that emerge from the mud banks. (pscnotes.com)
  • With an eye on environmental stewardship and wildlife habitat protection, natural features of the property have been incorporated into the site plan including a six acre lake, wetlands, specimen trees, and abundant native plantings. (buildingengines.com)

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