Biological Specimen Banks: Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.Microscopy, Electron, Scanning Transmission: A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.Forensic Toxicology: The application of TOXICOLOGY knowledge to questions of law.Holography: The recording of images in three-dimensional form on a photographic film by exposing it to a laser beam reflected from the object under study.Electron Microscope Tomography: A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Spectroscopy, Electron Energy-Loss: A technique for analysis of the chemical composition of molecules. A substance is bombarded with monochromatic ELECTRONS. Some of the electrons passing through the specimen will lose energy when they ionize inner shell electrons of the atoms in the specimen. The energy loss is element dependent. Analysis of the energy loss spectrum reveals the elemental composition of a specimen. ENERGY-FILTERED TRANSMISSION ELECTRON MICROSCOPY is a type of electron energy loss spectroscopy carried out in electron microscopes specially outfitted to analyze the spectrum of electron energy loss.Tissue Embedding: The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Microscopy: The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.Tissue Banks: Centers for acquiring, characterizing, and storing organs or tissue for future use.Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.Cryoelectron Microscopy: Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.Imaging, Three-Dimensional: The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.Microscopy, Fluorescence, Multiphoton: Fluorescence microscopy utilizing multiple low-energy photons to produce the excitation event of the fluorophore. Multiphoton microscopes have a simplified optical path in the emission side due to the lack of an emission pinhole, which is necessary with normal confocal microscopes. Ultimately this allows spatial isolation of the excitation event, enabling deeper imaging into optically thick tissue, while restricting photobleaching and phototoxicity to the area being imaged.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Electrons: Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Equipment Design: Methods of creating machines and devices.Microscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Eye Banks: Centers for storing various parts of the eye for future use.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Blood Banks: Centers for collecting, characterizing and storing human blood.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Bankruptcy: The state of legal insolvency with assets taken over by judicial process so that they may be distributed among creditors.BrazilTraining Support: Financial support for training including both student stipends and loans and training grants to institutions.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Papillomavirus Infections: Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Human papillomavirus 16: A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Human papillomavirus 18: A type of human papillomavirus especially associated with malignant tumors of the genital and RESPIRATORY MUCOSA.Oncogene Proteins, Viral: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.BooksGenomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Genetics, Medical: A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Health Policy: Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.Public Health Practice: The activities and endeavors of the public health services in a community on any level.Education, Nursing, Continuing: Educational programs designed to inform nurses of recent advances in their fields.Race Relations: Cultural contacts between people of different races.TexasCurriculum: A course of study offered by an educational institution.Rehabilitation Centers: Facilities which provide programs for rehabilitating the mentally or physically disabled individuals.Interdepartmental Relations: The interactions between representatives of institutional departments.Nutritional Sciences: The study of NUTRITION PROCESSES as well as the components of food, their actions, interaction, and balance in relation to health and disease.

Accessory DNA in the genomes of representatives of the Escherichia coli reference collection. (1/285)

Different strains of the Escherichia coli reference collection (ECOR) differ widely in chromosomal size. To analyze the nature of the differential gene pool carried by different strains, we have followed an approach in which random amplified polymorphic DNA (RAPD) was used to generate several PCR fragments. Those present in some but not all the strains were screened by hybridization to assess their distribution throughout the ECOR collection. Thirteen fragments with various degrees of occurrence were sequenced. Three of them corresponded to RAPD markers of widespread distribution. Of these, two were housekeeping genes shown by hybridization to be present in all the E. coli strains and in Salmonella enterica LT2; the third fragment contained a paralogous copy of dnaK with widespread, but not global, distribution. The other 10 RAPD markers were found in only a few strains. However, hybridization results demonstrated that four of them were actually present in a large selection of the ECOR collection (between 42 and 97% of the strains); three of these fragments contained open reading frames associated with phages or plasmids known in E. coli K-12. The remaining six fragments were present in only between one and four strains; of these, four fragments showed no similarity to any sequence in the databases, and the other two had low but significant similarity to a protein involved in the Klebsiella capsule synthesis and to RNA helicases of archaeal genomes, respectively. Their percent GC, dinucleotide content, and codon adaptation index suggested an exogenous origin by horizontal transfer. These results can be interpreted as reflecting the presence of a large pool of strain-specific genes, whose origin could be outside the species boundaries.  (+info)

Intraspecific diversity of the 23S rRNA gene and the spacer region downstream in Escherichia coli. (2/285)

The molecular microevolution of the 23S rRNA gene (rrl) plus the spacer downstream has been studied by sequencing of different operons from some representative strains of the Escherichia coli ECOR collection. The rrl gene was fully sequenced in six strains showing a total of 67 polymorphic sites, a level of variation per nucleotide similar to that found for the 16S rRNA gene (rrs) in a previous study. The size of the gene was highly conserved (2902 to 2905 nucleotides). Most polymorphic sites were clustered in five secondary-structure helices. Those regions in a large number of operons were sequenced, and several variations were found. Sequences of the same helix from two different strains were often widely divergent, and no intermediate forms existed. Intercistronic variability was detected, although it seemed to be lower than for the rrs gene. The presence of two characteristic sequences was determined by PCR analysis throughout all of the strains of the ECOR collection, and some correlations with the multilocus enzyme electrophoresis clusters were detected. The mode of variation of the rrl gene seems to be quite similar to that of the rrs gene. Homogenization of the gene families and transfer of sequences from different clonal lines could explain this pattern of variation detected; perhaps these factors are more relevant to evolution than single mutation. The spacer region between the 23S and 5S rRNA genes exhibited a highly polymorphic region, particularly at the 3' end.  (+info)

Mouse ENU mutagenesis. (3/285)

The progress of human genome sequencing is driving genetic approaches to define gene function. Strategies such as gene traps and chemical mutagenesis will soon generate a large mutant mouse resource. Point mutations induced by N -ethyl- N -nitrosourea (ENU) provide a unique mutant resource because they: (i) reflect the consequences of single gene change independent of position effects; (ii) provide a fine-structure dissection of protein function; (iii) display a range of mutant effects from complete or partial loss of function to exaggerated function; and (iv) discover gene functions in an unbiased manner. Phenotype-driven ENU screens in the mouse are emphasizing relevance to human clinical disease by targeting cardiology, physiology, neurology, immunity, hematopoiesis and mammalian development. Such approaches are extremely powerful in understanding complex human diseases and traits: the base-pair changes may accurately model base changes found in human diseases, and subtle mutant alleles in a standard genetic background provide the ability to analyze the consequences of compound genotypes. Ongoing mouse ENU mutagenesis experiments are generating a treasure trove of new mutations to allow an in-depth study of a single gene, a chromosomal region or a biological system.  (+info)

Distribution of intervening sequences in the genes for 23S rRNA and rRNA fragmentation among strains of the Salmonella reference collection B (SARB) and SARC sets. (4/285)

Intervening sequences (IVSs) occur sporadically in several bacterial genera in the genes for 23S rRNA at relatively conserved locations. They are cleaved after transcription and lead to the presence of fragmented rRNA, which is incorporated into the ribosomes without religation but is nevertheless functional. The fragmentation of rRNA and the number of IVSs in all 72 strains of the Salmonella Reference Collection B set and 16 strains of the Salmonella Reference Collection C set, which have been established on the basis of multilocus enzyme electrophoresis (MLEE), were analyzed in the present study. Fragmentation of 23S rRNA was restricted to conserved cleavage sites located at bp 550 (helix 25) and bp 1170 (helix 45), locations where IVSs have been reported. Random cleavage at sites where IVSs could not be detected was not seen. Uncleaved IVSs were not detected in any case; thus, the IVSs invariably led to rRNA fragmentation, indicating a strong selection for maintenance of RNase III cleavage sites. The distribution of the number of IVSs carried by the different strains in the seven rrl genes is diverse, and the pattern of IVS possession could not be related to the MLEE pattern among the various Salmonella strains tested; this indicates that the IVSs are frequently exchanged between strains by lateral transfer. All eight subspecies of the genus Salmonella, including subspecies V represented by Salmonella bongori, have IVSs in both helix 25 and helix 45; this indicates that IVSs entered the genus after its divergence from Escherichia coli (more than 100 million years ago) but before separation of the genus Salmonella into many forms or that they were in the ancestor but have been lost from Escherichia.  (+info)

Differences in genotypes of Helicobacter pylori from different human populations. (5/285)

DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric pathogen. Five types of deletion, insertion, and substitution motifs were found at the right end of the H. pylori cag pathogenicity island. Of the three most common motifs, type I predominated in Spaniards, native Peruvians, and Guatemalan Ladinos (mixed Amerindian-European ancestry) and also in native Africans and U.S. residents; type II predominated among Japanese and Chinese; and type III predominated in Indians from Calcutta. Sequences in the cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native Peruvians were also more like those from Spaniards than those from Asians. These indications of relatedness of Latin American and Spanish strains, despite the closer genetic relatedness of Amerindian and Asian people themselves, lead us to suggest that H. pylori may have been brought to the New World by European conquerors and colonists about 500 years ago. This thinking, in turn, suggests that H. pylori infection might have become widespread in people quite recently in human evolution.  (+info)

Cancer gene discovery using digital differential display. (6/285)

The Cancer Gene Anatomy Project database of the National Cancer Institute has thousands of expressed sequences, both known and novel, in the form of expressed sequence tags (ESTs). These ESTs, derived from diverse normal and tumor cDNA libraries, offer an attractive starting point for cancer gene discovery. Using a data-mining tool called Digital Differential Display (DDD) from the Cancer Gene Anatomy Project database, ESTs from six different solid tumor types (breast, colon, lung, ovary, pancreas, and prostate) were analyzed for differential expression. An electronic expression profile and chromosomal map position of these hits were generated from the Unigene database. The hits were categorized into major classes of genes including ribosomal proteins, enzymes, cell surface molecules, secretory proteins, adhesion molecules, and immunoglobulins and were found to be differentially expressed in these tumorderived libraries. Genes known to be up-regulated in prostate, breast, and pancreatic carcinomas were discovered by DDD, demonstrating the utility of this technique. Two hundred known genes and 500 novel sequences were discovered to be differentially expressed in these select tumor-derived libraries. Test genes were validated for expression specificity by reverse transcription-PCR, providing a proof of concept for gene discovery by DDD. A comprehensive database of hits can be accessed at http:// www.fau.edu/cmbb/publications/cancergenes. htm. This solid tumor DDD database should facilitate target identification for cancer diagnostics and therapeutics.  (+info)

exl, an exchangeable genetic island in Neisseria meningitidis. (7/285)

The genetic structure and evolution of a novel exchangeable meningococcal genomic island was defined for the important human pathogen Neisseria meningitidis. In 125 meningococcal strains tested, one of three unrelated nucleotide sequences, designated exl (exchangeable locus), was found between a gene required for heme utilization, hemO, and col, encoding a putative Escherichia coli collagenase homologue. The 5' boundary of each exl cassette was the stop codon of hemO, whereas the 3' boundary was delineated by a 33-bp repeat containing neisserial uptake sequences located downstream of col. One of the three alternative exl cassettes contained the meningococcal hemoglobin receptor gene, hmbR (exl3). In other meningococcal strains, hmbR was absent from the genome and was replaced by either a nucleotide sequence containing a novel open reading frame, exl2, or a cassette containing exl3. The proteins encoded by exl2 and exl3 had no significant amino acid homology to HmbR but contained six motifs that are also present in the lipoprotein components of the lactoferrin (LbpB), transferrin (TbpB), and hemoglobin-haptoglobin (HpuA) uptake systems. To determine the evolutionary relationships among meningococci carrying hmbR, exl2, or exl3, isolates representing 92 electrophoretic types were examined. hmbR was found throughout the population structure of N. meningitidis (genetic distance, >0.425), whereas exl2 and exl3 were found in clonal groups at genetic distances of <0.2. The commensal neisserial species were identified as reservoirs for all of the exl cassettes found in meningococci. The structure of these cassettes and their correlation with clonal groups emphasize the extensive gene pool and frequent horizontal DNA transfer events that contribute to the evolution and virulence of N. meningitidis.  (+info)

Recent events and observations pertaining to smallpox virus destruction in 2002. (8/285)

To destroy all remaining stocks of variola virus on or before 31 December 2002 seems an even more compelling goal today than it did in 1999, when the 52d World Health Assembly authorized temporary retention of remaining stocks to facilitate the possible development of (1) a more attenuated, less reactogenic smallpox vaccine and (2) an antiviral drug that could be used in treatment of patients with smallpox. We believe the deadline established in 1999 should be adhered to, given the potential outcomes of present research. Although verification that every country will have destroyed its stock of virus is impossible, it is reasonable to assume that the risk of a smallpox virus release would be diminished were the World Health Assembly to call on each country to destroy its stocks of smallpox virus and to state that any person, laboratory, or country found to have virus after date x would be guilty of a crime against humanity.  (+info)

*List of MeSH codes (N02)

... biological specimen banks MeSH N02.278.065.200 --- blood banks MeSH N02.278.065.600 --- milk banks MeSH N02.278.065.700 --- ... sperm banks MeSH N02.278.065.900 --- tissue banks MeSH N02.278.065.900.205 --- bone banks MeSH N02.278.065.900.400 --- eye ... banks MeSH N02.278.080 --- birthing centers MeSH N02.278.192 --- dental facilities MeSH N02.278.192.250 --- dental clinics MeSH ...

*Breast International Group

... incorporate a substantial translational research component and emphasise the collection and banking of biological specimens for ... will leave a lasting legacy in the form of a biological materials bank ("biobank"). Extremely valuable for translational ... and biological therapies, or to special groups of patients, such as the young or the elderly. BIG trials ...

*EM Data Bank

... collects 3D EM maps and associated experimental data determined using electron microscopy of biological specimens. It was ... The EM Data Bank or Electron Microscopy Data Bank (EMDB) ... EM Data Bank also provides the EMsearch search tool and data ... Software tools for molecular microscopy EM Data Bank US and UK Search pages Japan Search page (EM Navigator in PDBj). ... EMBL-EBI and PDBj EMDB is an archive for three-dimensional density maps of all types of biological assemblies, including ...

*Biorepository

Biobank Biological database Gene bank Genetic fingerprinting Genomics Genotype ISBER Newsletter Volume No.1, Issue No. 1 " ... The purpose of a biorepository is to maintain biological specimens, and associated information, for future use in research. The ... distribution of biological specimens. (i) Collection or accession is the first operation, whereby samples are recorded as ... Tissue Banks and Biorepositories National Institute of Allergies and Infectious Diseases HIV/AIDS Specimen Repository ...

*Biomedical tissue

When it is used for research it is a biological specimen. Such tissues and organs may be referred to as implant tissue, ... Tissue banks in the US are monitored by the Food and Drug Administration (FDA). The Code of Federal Regulations sets out the ... Tissue is stored in tissue establishments or tissue banks under cryogenic conditions. Fluids such as blood, blood products and ... 1] The UK Human Tissue Act 2004 Specimen Central biorepository list A worldwide listing of active biobanks and biorepositories ...

*Cell bank

In January 2003, the UK Stem Cell Bank was established to serve as a central unit for specimen collection and human testing. ... Organization established a reference cell bank to provide a resource for the development of vaccines and other biological ... A cell bank is a facility that stores cells of specific genome for the purpose of future use in a product or medicinal needs. ... Cell banks can be used to generate detailed characterizations of cell lines and can also help mitigate cross-contamination of a ...

*International Thylacine Specimen Database

... high-resolution digital images of the specimens are included. The ITSD specimen image bank forms the largest single ... All biological material deteriorates over time and these unique digital images will act as a permanent record of the specimens ... Wet specimens are whole animals, organs or body parts that have been preserved in either alcohol or formalin. Specimens of the ... The International Thylacine Specimen Database is a unique and precise database of the largest modern day marsupial carnivore. I ...

*Laboratory Response Network

They provide specialized reagents to lower level laboratories and have the ability to bank specimens, perform serotyping, and ... Cieslak, Theodore J. and George W. Christopher (2007), "Medical Management of Potential Biological Casualties: A Stepwise ... to handle specimens safely, and to forward specimens to higher-level labs within the network. These laboratories (more than 100 ... can rule on the presence of the various biological threat agents. They can use BSL-3 practices and can often conduct nucleic ...

*Specimen

... a biological laboratory specimen held by a biorepository for research Laboratory specimen, a biological specimen taken by ... for distribution to central banks to aid in the recognition of banknotes from a country other than their own Specimen stamp, a ... Specimen may refer to: Sample (material), a limited quantity of something which is intended to be similar to and represent a ... sampling Type specimen (mineralogy), a reference sample by which a mineral is defined Zoological specimen, an animal or part of ...

*Karl Ernst von Baer

Baer was interested in the northern part of Russia, and explored Novaya Zemlya in 1837, collecting biological specimens. Other ... erosion occurs mostly on the right banks of rivers, and in the Southern Hemisphere on the left banks. In its more thorough ... Before the Estonian conversion to the euro, the 2-kroon bank note bore his portrait. Baer Island in the Kara Sea was named ... He was a pioneer in studying biological time - the perception of time in different organisms. In 1849, he was elected a foreign ...

*International Society for Biological and Environmental Repositories

... and managerial issues relevant to repositories of biological and environmental specimens. ISBER is a professional society of ... ethical principles and innovation in biospecimen banking by uniting the global biobanking community. ISBER invites all sub- ... USA The availability of high quality biological and environmental specimens for research purposes requires the development of ... The score is based on possible risk to the specimens, frequency of implementation of each practice, and the ease with which ...

*Suzanne Anker

... tangled bank'." Anker frequently works with "pre-defined and found materials" botanical specimens, medical museum artifacts, ... Considered a pioneer in Bio Art., she has been working at the relationship of art and the biological sciences for more than ... The show focused on the intersection of art and the biological sciences, and the ethical and aesthetic dimensions therein. It ... "SUZANNE ANKER "Genetic Seed Bank" Lecture , Exhibition , UCLA Art , Sci Center + Lab". artsci.ucla.edu. Retrieved 2017-02-01. " ...

*Genomic Medicine Institute

The biorepository has received, cataloged, processed, and banked, in excess of 40,000 specimens. These samples are received ... and provides essential support for high-throughput biological studies on the genomic level. The Scientific Director is Prof ... and provides essential analysis for the integration of complex biological and clinical data to researchers across Lerner ... controlled absorption of plant sterols for cholesterol The Genomic Medicine Biorepository is a sample processing and banking ...

*Croatian Natural History Museum

The zoological collection consists of 1,135,000 animal specimens, including a tissue bank for DNA analysis. It also holds the ... In 1992, the museum began publishing Natura Croatica, a peer-reviewed biological and geological academic journal. The natural ... including over 1.1 million animal specimens. It was founded in 1846 as the "National Museum". The National Museum was later ...

*Scotian Shelf

About 230 individual specimens have been recorded there. Other species, such as the sperm whale and harbour seal, are also ... The water flow over the banks is weaker and tends have greater variation. The Scotian Shelf contains a canyon called the "Gully ... "Biological Importance of Scotian Shelf Water" (PDF). Grampus.umeoce.maine.edu. Retrieved 27 November 2017. Image Benthic ... The Scotian Shelf is characterized by shallow, offshore banks 25 m to 100 m under the ocean surface, with deep basins and ...

*ZooBank

Type Specimens record the biological type specimens of animals which are provisionally registered, until the bodies responsible ... "Zoologists bank on database". Information World Review. Archived from the original on 12 April 2006. Pyle, Richard L.; Michel, ... Ellinor (2008). "ZooBank: Developing a nomenclatural tool for unifying 250 years of biological information" (PDF). Zootaxa ( ...

*Craugastor phasma

The holotype was found on a rocky stream bank in lower montane rainforest at 1,850 m (6,070 ft) above sea level. The site was ... It is unusual in its ghost-like, gray-white coloration, and it was initially thought that the specimen was an albino form of ... Proceedings of the Biological Society of Washington. 109: 744-748. Frost, Darrel R. (2017). "Craugastor phasma (Lips and Savage ... However, the specimen is also morphologically distinct, although some uncertainty regarding the validity of this species ...

*Badgeworth SSSI, Gloucestershire

Ripe seed was collected in 1991, and sent for storage in the Kew Seed bank. A fuller description is available in the reserve ... Badgeworth SSSI (grid reference SO 911206) is a 3.08-hectare (7.6-acre) biological Site of Special Scientific Interest in ... of a Badgeworth specimen) Guy, C, Haigh, D, Harris, Lucy, Harris, Lyn, Parker, J, Ralphs, I, Tandy, C, (1977 edition edited ... This could be an old seed bank or spread on the feet of animals or birds. Hanbury, F J, (1890), 'Ranunculus ophioglossifolius ...

*Richard C. Banks

Banks, Richard C.; Goodman, S. M.; Lanyon, S. M.; and Schulenberg, T. S. (1993). "Type Specimens and Basic Principles of Avian ... Banks, Richard C. (2011). "Taxonomy of Greater White-fronted Geese", (Aves: Anatidae), Proceedings of the Biological Society of ... Hubbard, John P.; and Banks, Richard C. (1970). "The Types of Taxa of Harold H. Bailey", Proceedings of the Biological Society ... Woolfenden, G. E.; and Banks, Richard C. (2004). "A specimen of the Varied Thrush from Florida", Florida Field Naturalist, 32: ...

*Type site

The use of this term is therefore similar to that of the specimen type in biology (see biological types) or locus typicus (type ... For example, the type site of the Pre-Pottery Neolithic A culture is Jericho, in the West Bank. A type site is also often the ...

*Teratohyla adenocheira

... although a specimen has also been collected in a secondary forest on a river bank, on the surface of the palm Lepidocaryum. The ... Proceedings of the Biological Society of Washington. 118 (2): 428-441. doi:10.2988/0006-324X(2005)118[428:BGFACW]2.0.CO;2. ... Adult males in the type series (three specimens) measure 21.4-22.4 mm (0.84-0.88 in) in snout-vent length (SVL). An unsexed ... specimen from Rondônia measured 25 mm (0.98 in) SVL. The head wider than the body. The snout is short and round in dorsal view ...

*Aspatria Agricultural College

Returned J. Banks, Middlesex Yeomanry; W.B. Caverhill, Berwick Yeomanry; T. Custance, Strathcona's Horse; Lieut. D.H. Greig, ... The biological laboratory occupied the tower. The room furnished with microscopes and other apparatus associated with Botanical ... In addition to a section devoted to soils and specimens of rocks and fossils the museum housed a variety of animal curiosities ... There was a collection of natural history specimens displayed in each corner of the hall. These included a magnificent Bengal ...

*Repository for Germinal Choice

... who searches for his biological father. Heritability of IQ David Plotz (February 23, 2001). "The Myths of the Nobel Sperm Bank ... intending to donate specimens, only to leave after Sheldon suffers a moral crisis over committing "genetic fraud" by donating ... The genius sperm bank "Pilot". The Big Bang Theory. Season 1. 2007-09-24. CBS. Escobedo, Tricia. "A sperm bank just for ... a businessman from Ohio who had shown interest in the bank. At the time of Graham's death, the bank claimed to have produced ...

*USC&GS A. D. Bache (1871)

... the ship engaged in bottom dredging to sample the bottom and obtain biological specimens. During dredging in the Gulf, largely ... When weather offshore was unfavorable the ship developed the vicinity of the rock and rock ledges nearby with a new bank ... Bache left the Gulf for New York, arriving May 23, for repairs before engaging in hydrographic surveys of Georges Bank off ... Atlantic service The Story Of The Bureau Of Commercial Fisheries Biological Laboratory Woods Hole, Massachusetts (6.24mb .pdf ...

*Health Sciences Authority

The agency is also a United Nations International Drug Control Programme Reference Laboratory for Biological Specimens and ... HSA has been internationally accredited by the AABB (formerly known as the American Association of Blood Banks), and also the ... It runs the [email protected] in Outram, as well as three satellite blood banks - [email protected], [email protected] and ... it secures the national blood supply through its operation of the national blood bank - [email protected]; and it represents the ...

*Cycadales

They typically grow very slowly and live very long, with some specimens known to be as much as 1,000 years old. Because of the ... In January 1697, Dutch sailors landed on the banks of the Swan River in Western Australia, part of the crew of the Nyptang, one ... Cycadales belong to the biological division Cycadophyta along with the fossil order Medullosales. The three extant families of ... 76 Endeavour Journal of Joseph Banks, Vol. 2, pg. 115 Hawksworth 1785, An account of the voyages for making discoveries in the ...
TY - JOUR. T1 - Cohort profile. T2 - Design and methods in the eye and vision consortium of UK Biobank. AU - UK Biobank Eye and Vision Consortium. AU - Chua, Sharon Yu Lin. AU - Thomas, Dhanes. AU - Allen, Naomi. AU - Lotery, Andrew. AU - Desai, Parul. AU - Patel, Praveen. AU - Muthy, Zaynah. AU - Sudlow, Cathie. AU - Peto, Tunde. AU - Khaw, Peng Tee. AU - Foster, Paul J.. AU - Trucco, Emanuele. PY - 2019/2/21. Y1 - 2019/2/21. N2 - Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, ...
This fact sheet provides information for NHS, Health Professionals Follow-up Study (HPFS), and Growing Up Today Study (GUTS) participants with biospecimens in the Brigham and Womens Hospital (BWH) / Harvard Cohorts Biorepository. Overview Thank you for participating in the BWH/Harvard Cohorts Biorepository. This fact sheet provides more information about the biorepository.
UK Biobank aims to assess the relevance of a very wide range of health-related outcomes. It is a large prospective study to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. During 2006-2010, UK Biobank conducted its recruitment phase of more than 500,000 participants who gave their consent, answered questions, had physical measurements and gave samples (blood, urine and saliva) at a Baseline assessment visit. Follow-up of their health is now being conducted through medical and other health-related records. Access systems have been developed to facilitate use of the UK Biobank Resource by bona fide researchers for health-related research that is in the public interest ...
Biospecimens collected by the CONCERT Biobank are made available to researchers on the provision that use of specimens are for scientifically valid and ethically approved research projects.. Researcher access entails search facilities which allow for researchers to search biospecimen type and availability stored in the CONCERT Biobank using a link from the CONCERT TCRC website to the Biobanks database, which is currently still under development. All biospecimens and information are stored securely and de-identified however they are re-identifiable to CONCERT Biobank personnel who have signed confidentially agreements. Search facilities on the database protect all identifiable information of the participant.. Currently, as the CONCERT Biobank is still in the progress of developing and implementing its database, researchers can request the use of biospecimens by contacting the CONCERT Biobank manager through the Ingham Institute for Applied Medical Researchs Biobank page, ...
The goal of personalized medicine has ushered in the transition from empirical medicine to molecular medicine. Thus during research, biobanks are key infrastructures for biomedical R& D because at one time or another, these biospecimens have been stored in a biobank. Well-annotated biospecimens and their associated clinical data accelerate translational and clinical research discoveries. However, high-throughput molecular sequencing and increased biosample variety have introduced significant informatics challenges for biobanking infrastructures. Meanwhile, the lack of high-quality biospecimens both stalls projects and limits research advances. Cambridge Healthtech Institutes Ninth International Leaders in Biobanking Congress addresses biospecimen science, management, and applications, bringing together biomedical and biopharmaceutical researchers, regulators, biorepository managers and practitioners to investigate the best strategies for effective use of biospecimens within todays cutting-edge
How Biorepositories Can Help Your Research. Tatiana Foroud, Ph.D. Department of Medical and Molecular Genetics. Overview. Sample collection for genetic studies Typical DNA applications for genetic studies Results from several ongoing studies. Collecting Samples for Genetic Studies. Slideshow 6743902 by dominica-ronnie
In this webinar, we briefly discussed the regulatory considerations for biorepositories including the following: When HHS, FDA and HIPAA regulations apply, Whe…
Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK
1. Dekkers IA, Jansen PR, Lamb HJ. Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study. Radiology. 2019 Apr 23:181012.. 2. Hwang LD, Lin C, Gharahkhani P, Cuellar-Partida G, Ong JS, An Gordon SD, Zhu G, MacGregor S, Lawlor DA, Breslin PAS, Wright MJ, Martin NG, Reed DR. New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. Am J Clin Nutr. 2019 Apr 21. pii: nqz043.. 3. Machado-Fragua MD, Struijk EA, Ballesteros JM, Ortolá R, Rodriguez Artalejo F, Lopez-Garcia E. Habitual coffee consumption and risk of falls in 2 European cohorts of older adults. Am J Clin Nutr. 2019 Apr 21. pii: nqy369.. 4. Hajna S, White T, Panter J, Brage S, Wijndaele K, Woodcock J, Ogilvie D, Imamura F, Griffin SJ. Driving status, travel modes and accelerometer assessed physical activity in younger, middle-aged and older adults: a prospective study of 90 810 UK Biobank participants. Int J Epidemiol. 2019 Apr 19. pii: ...
From managing the storage and maintenance of annotated specimen data to following the chain of custody and making determinations about a sample quickly and accurately, a biobanking LIMS requires standard features to meet the needs of the community.. At LabVantage, for example, we designed our biobanking LIMS to address these concerns using a centralized LIMS for efficient, accurate, and secure tracking of biobank samples and consents.. Want to learn more? Read our latest article in Genetic Engineering & Biotechnology News.. Interested in learning how a LIMS built specifically for Biobanking can better support your organization by tearing down your data silos and maximizing the insights you draw from your biobank data? Contact us today.. ...
Biobanking strategies and regulative approaches in the EU: recent perspectives Katharina Beier,1 Christian Lenk2 1Department of Medical Ethics and History of Medicine, University Medical Center Göttingen, Göttingen, Germany; 2Institute of the History, Philosophy, and Ethics of Medicine, Ulm University, Ulm, Germany Abstract: Biobanks, ie, systematic collections of human biological materials and associated clinical and lifestyle data, provide an indispensable infrastructure for modern research. Although biobank research takes place on a global scale, there is no internationally binding framework for its ethical and legal regulation yet. A better understanding of existing regulative approaches is an important prerequisite for its ethical and legal harmonization and, thus, for improving the interoperability of biobank-based research in the future. This review focuses on biobanking strategies, regulative approaches, and recent developments in Europe. Specifically, we discuss selected ethical and
Biobank consent models – are we moving toward increased participant engagement in biobanking? Berge Solberg, Kristin Solum Steinsbekk Department of Public Health and General Practice, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Abstract: Engagement, involvement, and active participation are buzzwords used in today's ethical debate on research biobanking. There are a variety of context-sensitive governance frameworks for research biobanks. However, many biobanks, especially large-scale population-based ones, seem to endorse a framework of broad consent, participation with minimal or no ongoing engagement, and no return of results. An alternative vision of involvement and active participation in this type of research has become increasingly visible in the literature. The problem, seen from the biobankers' perspective, is that the alternative vision might be costly, cumbersome, and risky, while the prevailing system for governance will maximize the scientific
There are several characteristics of COLS that differentiate it from existing repositories.. First, most biobanks are created to study a given disease and consist of samples from ill patients. In contrast, COLS is disease inclusive by design. Many participants will be well when they enter the study; although, some will have chronic diseases at the outset. COLS will continue collecting samples for a decade. As people become ill that data will be captured in the bank. Therefore, both rare and common diseases will be represented over time because of the size of the cohort.. Second, COLS is omics exhaustive; that is blood and urine will be collected and stored in a way that preserves multiple molecules. Most biobanks are designed to preserve only one molecule, most commonly DNA. Previously, the dogma was that the genome was the key to understanding health and disease. We now understand that most diseases cannot be explained solely by ones genome, but instead by dynamic changes in molecules such as ...
CTSI Biorepository Biospecimen collection, processing and storage. Stored biospecimens can be used by any researcher with IRB approved protocols. Prospective biospecimen collection to fulfill investigator needs for IRB approved protocols. Storage for biospecimens collected by investigators. Stored biospecimens belong solely to the investigator. Oversight of the release of biospecimens from the UF Department of Pathology for other IRB approved research protocols. Pathology services including those provided by the Molecular Pathology Core and confirmation of diagnosis by a board certified pathologist upon request. The UF CTSI is supported in part by NIH awards UL1 TR000064, KL2 TR000065 and TL1 TR000066 One of two Hamilton 80 C automated sample management systems (Robotic freezers ). The biorepository also has eight Forma Thermo Scientific 80 C Freezers with back up CO 2 and sensaphone alarm systems including back up storage space, centrifuge for basic bodily fluid processing, QiaCube for small ...
How many clinics in Texas market stem cell procedures? What interventions do they promote? How many adult stem cell banks are located in Texas? How do they advertise their services?. There does not appear to be a comprehensive record of stem cell banks and clinics marketing stem cell procedures within the state of Texas. I am therefore trying to determine how many stem cell banks and clinics marketing stem cells in Texas can be found using an approach that a patient or customer might take when searching the Internet. In an effort to locate such businesses, I used Google search engine and entered such terms as "stem cells Texas", "stem cell clinics Texas", "cosmetic surgery stem cell Texas", "orthopedic surgery stem cell clinic Texas", and "anti-aging stem cells Texas". In total, I found twenty businesses marketing what they describe as stem cell procedures as well as three stem cell banks. During my search I also noticed and recorded a spa marketing "plant stem cells" and a dentist who ...
The overall goal of this project is to identify strategies to reduce lung cancer incidence and mortality. Using a high-risk occupational cohort, our specific objectives are 1) to establish a biologic specimen bank and data bank that can be used for the validation and refinement of potential early markers of lung cancer, and 2) to establish a cohort for the study of environmental (including dietary) and genetic risk factors for lung cancer.. Lung cancer is the leading cause of death from malignant neoplasms in the United States and in many countries around the world. Potential strategies to reduce the incidence and mortality of lung cancer include new methods of early detection and identification and alteration of etiologic factors.. The Yunnan Tin Corporation (YTC), located in Yunnan Province in southern China, is a large, nonferrous-metals industry, formed in 1883 and nationalized after the establishment of the Peoples Republic in 1949. It is involved principally in the production of tin from ...
ProteoGenex has a centralized biorepository of over 200,000 human clinical specimens in a wide variety of formats (FFPE & Frozen Tissues, Serum/Plasma, etc)
The Massachusetts General Hospital Cardiovascular Biorepository (CVBio) advances cardiovascular research by providing patient data and blood samples to help researchers understand how genes and other factors contribute to heart disease.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: National Gene Vector Biorepository and Coordinating Center (P40) RFA-RR-07-002. NCRR
The Biorepository and Pathology CoRE is a multi-dimensional service group providing consultation and technical support for the translational and basic science groups across MSHS.
Rogena, J., Kihara, A. and Kemp, S. 2014. Monitoring ILRIs biorepository. Poster presented at the 50th Anniversary Celebration and Annual Scientific Conference for the Society of Low Temperature Biology, London, UK, 8-10 October 2014 ...
Biobanking 2018 will bring together the worlds leading experts in biorepositories, policy makers, and scientific actors to strengthen knowledge in biobanking as well as explore future advances in the field of biosampling for precision medicine, drug development and health research.
Biorepositories are highly complex research facilities with expert staff to process, store, characterize and secure biological specimens and their corresponding clinical information. The Biopathology Center at Nationwide Childrens Hospital, the hospitals long-standing biorepository, has received accreditation from the College of American Pathologists, confirming that the biorepository operates to ensure that high-quality biospecimens and related data are available for the purpose of supporting cutting-edge medical research.
The aim of this thesis is to investigate the relationship between individuals and society in the context of healthcare and medical research, more specifically concerning the rights and duties of individuals in regard to biobank-based research. My starting point is that we all have a strong vested interest in improved healthcare, and therefore the possibilities to conduct important research should be optimized. In the first article, I investigate whether individual results from research using samples in large-scale biobanks should be returned. I conclude that there is good reason not to implement such policies, and instead to allocate available resources to pursuing medical advances. In the second article, I compare consent for using stored samples in research with consent for organ donation, whereby many countries have adopted opt-out strategies in order to increase the number of organs available. I claim that the default position should be changed in biobank research as well, i.e. it should be ...
Carolinas HealthCare System recently created a BioSpecimen Repository on its Mint Hill campus, which will ultimately enhance researchers understanding of how to more effectively treat a broad range of diseases. Carol J. Farhangfar, PhD, MBA, Assistant Vice President of Carolinas HealthCare Systems Tissue Procurement and Levine Cancer Institutes Translational Research, is overseeing the development of the Repository and discusses its significance for providers and patients. Q: Why was the Biospecimen Repository created at CHS, and how will it enhance our research efforts? The BioSpecimen Repository (BSR) was created at CHS to provide a comprehensive, enterprise-wide system to collect, process, store, and distribute high quality biospecimens for clinical and translational research. It will enhance the capabilities of dedicated CHS investigators and enable the evolution of CHS into a nationally recognized clinical service provider that can leverage tissues and other biospecimens to help us ...
Biobanks are an important resource for the research and development of cell and gene therapies, but biobanking requires the careful consideration of ethics and patient privacy, and carries issues around lack of inclusion of ethnic minorities. Furthermore, biobanks for cell therapies are still in their infancy in terms of potential to have a significant impact on healthcare: large, clinical-grade banks of cells, whether induced pluripotent stem cells or other, with diverse genetic backgrounds will be needed for widespread clinical application of cellular therapies. This channel includes content around all these different aspects, including the latest news and opinion, and top peer-reviewed articles.
Abstract Finland has enacted a Biobank Act that will come into force on 1 September 2013. Finland is regarded as a highly successful environment for medical research using population samples and data for many reasons. One of the rationales behind the new legislation was to solve the problems due to the overly strict informed consent doctrine hindering access to old samples and data and asking for multi-purpose consents. Yet although consent is the primary justification to use biobank samples and data, the Biobank Act allows asking for a consent for several unspecified future research purposes. The guiding principles of the Biobank Act are promotion of trust, equal access to data and samples, protection of privacy, acceleration of innovation activities, and bringing biobank activities under public scrutiny. To the authors knowledge, this is the first
Health-care research relies largely on human materials stored in highly specialised biorepositories. Medical translational research on tissues can be performed using a variety of resources in distinct situations. The best known is the secondary use of pathology archives where paraffin-embedded tissues are stored for diagnostic reasons. Another is collecting and storing frozen material obtained from leftover surgical diagnosis. Such residual tissues can either be used directly in research projects or used in the context of a clinical trial with new interventional medicinal products. The latter can make the regulations governing the use of these materials for medical research much more complicated. The use of residual materials is very distinct from biobanking projects for which tissue is specifically collected. This article describes the consequences of using residual human material from different sources in distinct situations and why signed informed consent is not always the preferred choice of ...
Purpose: Biospecimens (e.g. tissues, bloods, fluids) are critical for translational cancer research to generate the necessary knowledge to guide implementation of precision medicine. Rising demand and the need for higher quality biospecimens are already evident. Methods: The recent increase in requirement for biospecimen complexity in terms of linked biospecimen types, multiple preservation formats, and longitudinal data was explored by assessing trends in cancer research publications from 2000 to 2014. Results: A Pubmed search shows that there has been an increase in both raw numbers and the relative proportion (adjusted for total numbers of papers in each period) of the subgroups of papers typically associated with the use of biospecimens and both dense treatment and/or outcomes data and multiple biospecimen formats. Conclusions: Increasing biospecimen complexity is a largely unrecognized and new pressure on cancer research biobanks. New approaches to cancer biospecimen resources are needed ...
Trans-Hit Bio is the worldwide biospecimen access CRO with the most extensive collection capability for biospecimens and clinical samples through an unrivaled worldwide partnered-network of state-of-the-art academic biorepositories and clinical sites.. ...
Trans-Hit Bio is the worldwide biospecimen access CRO with the most extensive collection capability for biospecimens and clinical samples through an unrivaled worldwide partnered-network of state-of-the-art academic biorepositories and clinical sites.. ...
These results demonstrate the potential to leverage existing biorepositories to support research in a powerful new way. While tissue banks in various forms have existed for over 60 years, demand for human tissue for personalized medicine and associated genetic studies, which require large biorepositories, has accelerated the rate of establishment of new facilities [11, 12]. A recent survey has identified at least 636 U.S. biobanks, 36% of which have postmortem tissue, 9% exclusively (largely brain banks) [11]. Archival specimens that were not intended for iPSC generation at the time of harvesting have the potential to be unlocked for functional studies to test mechanistic hypotheses. Preliminary results suggest other banked brain tissues, including leptomeninges and the large artery associated with the choroid plexus, can also produce outgrowths both morphologically similar and distinct from fibroblasts (data not shown). In addition, while many collections store solid tissues, there are other ...
Owing to the system now being developed at Karolinska Institutet in Stockholm, and that was presented this week at an international conference on biobanks, the universitys biobank will now be based on informatics as well as tissue and blood samples. The system will enable researchers to seek biobank samples linked to the vast databases of phenotype and genotype information on the individual donors and to a variety of other data sources.. ...
Under the direction of Kevan Herold, MD, YCCIs deputy director of translational science and professor of immunobiology and of medicine (endocrinology), YCCIs biospecimen unit can help investigators manage biospecimens electronically. YCCI has staff members to help investigators manage biospecimens electronically and develop case report forms for specimen collection. Staff can help investigators make the most of OnCores Biospecimen Management (BSM) module, which keeps track of sample inventory, collection, processing, storage, and distribution in a secure environment. BSM is paired with a Unified Registries Management (URM) module that uses electronic case report forms for research subject registries and is able to track clinical outcomes. Implemented in 2013, this service provides easy access to data while storing them in a HIPAA-secure environment. Additional security features help investigators manage specimens associated with multicenter trials by allowing collaborating institutions to ...
We have said that informed consent, problems it faces in biobanking and the need for alternative models are a key source of issues in biobanking ethics. Unsurprisingly then, several of the papers in this issue concern or touch on the questions of informed consent. In their analysis of the New Belgian Law on Biobanks Sigrid Sterckx and Kristof Van Assche note some of the legal and ethical implications of this law regarding consent, for example that it allows for presumed consent to research in the case of residual materials. Interestingly, and worryingly for Sterckx and Van Assche, such material is deemed residual if it was extracted for diagnostic purposes, but unless the patient explicitly requests otherwise their consent to its use in research is, apparently, not merely tacitly assumed but presumed.Tacit consent to certain instances of research is one thing when a donor has agreed that their material at least may be used in some kind of research, but it is quite another in cases ...
Molecular Medicine Ireland, in partnership with UCD School of Medicine & Medical Science, held its first Biobanking Course in the UCD Clinical Research Centre (CRC) at the Mater Misericordiae University Hospital from 17-19 April. The course was run in conjunction with the Biorepositories module of UCDs Graduate Certificate in Clinical and Translational Research.. There were 25 attendees on the MMI Biobanking Course comprising clinicians, research nurses, lab managers, scientists and post-graduate researchers from a number of institutions including MMI partner institutions and their associated teaching hospitals: UCD, UCC, Trinity College, Dublin City University, the Mater Misericordiae and St Vincents University Hospitals, St Jamess Hospital, Mercy University Hospital and the Mid-Western Regional Hospital. The MMI Biobanking Course featured both practical and theoretical sessions in subject areas relating to the collection, processing and storage of biological samples for use in clinical and ...
Addition of leading suppliers bolsters Precisions biomarker service offerings - bringing unparalleled science, scale, and service to the biospecimen industry. BETHESDA, MD - August 1, 2019 - Precision for Medicine, part of Precision Medicine Group, announced it has acquired leading biospecimen providers ProMedDx and GLAS, significantly expanding its capabilities and expertise in the biospecimen solutions space. With the acquisitions, Precision now offers an unmatched level of scientific understanding, high-quality specimen solutions, and global scale.. The addition of ProMedDx and GLAS establishes an unrivaled biospecimen solutions platform within Precision, which operates one of the largest biorepositories in the world. ProMedDx is known throughout the diagnostics industry for its high-quality biofluid specimens, while GLAS is a leader in tissue-based samples. With an expanded sourcing network and client base, along with an enhanced global laboratory infrastructure, Precision can effectively ...
TTP Labtech will showcase its affordable and compact automated biobanking systems at the upcoming SLAS 2013 conference and exhibition in Orlando, FL, USA from 12-16 January. The company will be demonstrating the unique benefits of comPOUND® and arktic™ fully automated storage modules and its lab2lab® sample transport solution. As part of the biobanking sample management workflow the fully automated capper, decapper and mosquito®, the low volume liquid pipetting solution for assay prepara
Biobanking Market - Global Analysis, regional market share, growth, trends, forecast, Global Biobanking Market Outlook (2016-2022)
The UK Stem Cell Line Registry (PDF, 113KB) lists human embryonic stem cell lines that have been approved by the Steering Committee for use in the UK (including importation).. However, whilst the individual lines have been approved for use in the UK, UK researchers wishing to use/import these cell lines must in addition apply to the Steering Committee for specific approval of their research project.. An increasing number of lines are being made available through the UK Stem Cell Bank. It is considered best practice to use the UK Stem Cell Bank where possible, in order to ensure that researchers are working with high quality, standardised cell lines.. ...
Current restrictions for human cell-based therapies have been related to technological limitations with regards to cellular proliferation capacity, maintenance of differentiated phenotype for primary human cell culture, and transmission of communicable diseases. We have seen that cultured primary fetal cells from one organ donation could possibly meet the exigent and stringent technical aspects for development of therapeutic products. We could develop a master cell bank (MCB) of 50 homogenous ampoules of 4-5 million cells each from one fetal organ donation (skin) in short periods of time compared to other primary cell types. Safety tests were performed at all stages of the cell banking. MCB ampoules could create a working cell bank to be used for clinical or research use. Monolayer culture of fetal skin cells had a life span of 12-17 passages, and independent cultures obtained from the same organ donation were consistent for protein concentration (with 1.4-fold maximal difference between ...
Authoritative yet accessible, Human Biological Variation, Second Edition, opens with an engaging introduction to basic genetics and the evolutionary forces that set the stage for understanding human diversity. It goes on to offer a clear and detailed discussion of molecular genetics, including its uses and its relationship to anthropological and evolutionary models.
Here is the best resource for homework help with INTEG BIO 35AC : HUMAN BIOLOGICAL VARIATION at Berkeley. Find INTEG BIO35AC study guides, notes, and practice
Cureline is a global human biospecimens biotech company providing effective solutions for scientific and clinical research projects. The company was founded by a group of scientists and biotech entrepreneurs, who established the human tissue biorepository for SUGEN (acquired by Pharmacia/ Pfizer) and contributed in the development the successful cancer therapy sunitinib Sutent® (Pfizer).
SHREWSBURY, Mass. (AP) - The stem cell bank at the University of Massachusetts is set to run out of cash and close at the end of this year.State and university officials tell The Boston Globe (http://bo.st/LQi71Z ) that changes in technology and federal policies around stem cell research have made obsolete the facility at the U-Mass Medical Centers Shrewsbury campus.The stem cell bank was established in 2008 with the help of $8.6 million state funding, part of Gov. Deval Patricks effort
Regulatory agencies require cell bank manufacturers to ensure continued stability and safety of cell lines producing products for human use. Recommendations for cell line or cell bank testing are dependent on the species being used and the intended purpose of the product produced. Regulatory agencies determine which tests must be performed based on the species and the product, but the testing will include identity, stability, and purity.
We next analyzed UK Biobank population structure in conjunction with ancient DNA samples. Modern European populations are known to have descended from three ancestral populations: Steppe, Mesolithic Europeans and Neolithic farmers 21,22 . We projected ancient samples from these three populations as well as ancient Saxon samples 24 onto the UK Biobank PCs (Figure 3, Supplementary Figure 4, see Online Methods). These populations were primarily differentiated along PC1 and PC3, indicating higher levels of Steppe ancestry in northern UK populations. Additionally, the lack of any ancient sample correlation with PC2 suggests that Welsh populations are not differentially admixed with any ancient population in our data set, and likely underwent Welsh-specific genetic drift. We confirmed these findings by projecting pan- European POPRES 26 samples onto the UK Biobank PCs (see Online Methods, Supplementary Figure 5) noting that of the continental European populations, Russians (who have the most Steppe ...
The purpose of this acquisition is to support infrastructure and capacity to store and maintain biospecimens and clinical data collected from participants enrolled in the Sjogrens International Collaborative Clinical Alliance (SICCA) study and to distribute these specimens and the accompanying clinical data to qualified investigators.. ...
SBPs vision is to help Switzerland consolidate its position at the forefront of biomedical research by facilitating access and optimal usage of its existing and future biobanked specimens.. Considering the fact that sample quality is the cornerstone of a biobanks reputation, the SBP mission is to develop a reliable customer-oriented network of biobanks in Switzerland with harmonized processes in terms of:. ...
Ademuyiwa FO, Bshara W, Attwood K, Morrison C, Edge SB, Ambrosone CB, OConnor TL, Levine EG, Miliotto A, Ritter E, Ritter G, Gnjatic S, Odunsi K. NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer. PLoS One. 2012; 7(6):e38783. PMCID: PMC3386262 Choi JY, James SR, Link PA, McCann SE, Hong CC, Davis W, Nesline MK, Ambrosone CB, Karpf AR.Association between global DNA hypomethylation in leukocytes and risk of breast cancer.Carcinogenesis. 2009 Nov;30(11):1889-97. PMCID: PMC2783000
The Molecular Core accepts samples from the NTM Culture, Biorepository, and Coordinating Core. Samples are analyzed using whole genome sequencing (WGS) and comparative phylogenomic methods. These results are communicated back to the NTM Culture, Biorepository, and Coordinating Core, for dissemination to the referring Centers.
AHRI reserves the right in special circumstances to accept late applications or to extend the above date to facilitate further searches. Furthermore, AHRI reserves the right not to make an appointment. Please consider your application unsuccessful if you have not been contacted within 4 weeks of the closing date ...
Brooks Life Science Systems has announced that Karolinska Institute Biobank (KI Biobank) is successfully using Brooks REMP single-use heat sealed sample tubes to secure the long-term storage of plasma, serum and urine samples in its automated biorepositories.
The UNICORN consists of two collaborating biobanks, one in Utrecht and one in Singapore. From these two sites we include all patients who undergo a coronary catheterization for any reason.. At the moment of catheterization we draw blood, which will be stored in a biobank and we collect clinical characteristics. Patients are followed-up for 5 years for the occurrence of major cardiovascular events.. By including from two sites in the world we include 4 major ethnic groups: Caucasians, Chinese, Indians and Malays. We aim at including at least 2000 patients per ethnic group.. Our hypothesis is that there are differences in the risk factor burden, clinical presentation of CAD, and biochemical patterns in the blood among the ethnic groups.. Furthermore, this biobank offers a platform for multi-ethnic biomarker discovery. ...
Press Release issued Jul 22, 2015: The purpose of this global strategic report is to prepare executives, company management, and industry investors with the data and knowledge necessary to make informed, educated decisions about commercial opportunities within the stem cell biobanking market.
According to Stratistics MRC, the Global Biobanking Market is expected to grow at a CAGR of 9.5% during the forecast period. Factors such as occurrence of chronic diseases, increase
The UK Biobank plans to collect DNA samples from 5,00,000 Britons to unravel the genetic basis of several killer diseases including cancer, heart disease, diabetes, dementia and joint problems
The mission of the DNASU Plasmid Repository is to accelerate research by providing high-quality, annotated plasmid samples and online plasmid resources to the research community through the curated DNASU database, website and repository (http://dnasu.asu.edu or http://dnasu.org). The collection includes plasmids from grant-funded, high-throughput cloning projects performed in our laboratory, plasmids from external researchers, and large collections from consortia such as the ORFeome Collaboration and the NIGMS-funded Protein Structure Initiative: Biology (PSI:Biology). Through DNASU, researchers can search for and access detailed information about each plasmid such as the full length gene insert sequence, vector information, associated publications, and links to external .... ...
Although restrictions on clinical trials on animals are far less than on humans, TANUVAS has decided against using embryonic cells because of the ongoing moral debate about using human embryos. Dr Jestin Williams, principal investigator, TANUVAS, who will be in charge of the stem cell bank, says a small sample (about two tablespoons) of a dogs own fat drawn from the animals belly would be given to NCRM to isolate regenerative cells. The cells will then be returned either in ready-to-inject syringes for therapy or research, or in vials for storage. The stem cells will then be injected directly into the animals joint or any other area that needs treatment, he says ...
HSLF-FS 2018:7 3. PA/PH/SG (17) 63 PUB CHARACTERISATION OF THE PRODUCER MICRO-ORGANISM. The history of the micro-organism used for production is documented. The. micro-organism is adequately characterised. This may include determination of. the phenotype of the micro-organism, macroscopic and microscopic methods. and biochemical tests and, if appropriate, determination of the genotype of the. micro-organism and molecular genetic tests.. PROCESSES USING A SEED-LOT SYSTEM. The master cell bank is a homogeneous suspension or lyophilisate of the original cells. distributed into individual containers for storage. The viability and productivity of. the cells under the selected storage conditions and their suitability for initiating a. satisfactory production process after storage must be demonstrated.. Propagation of the master cell bank may take place through a seed-lot system that uses a. working cell bank.. The working cell bank is a homogeneous suspension or lyophilisate of the cell ...
Stem Cells Bank este un laborator dedicat procesarii sangelui ombilicoplacentar si depozitarii valoroaselor celule stem care pot fi gasite in sangele ombilicoplacentar.
The Swedish Biobanks in Medical Care Act (SFS 2002:297) allows the use of human biological specimens that have been collected and/or stored within healthcare, for research and clinical trials if t...
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Results By 2023, ,900 new cases of each of wet (neovascular) and dry age-related macular degeneration, ,1200 cases of primary open angle glaucoma and almost 15 000 cases of cataracts are expected to have accrued in the subcohort of 68 500 participants who had ocular assessment at baseline, with around seven times as many cases of each disease in the whole cohort of 500 000 participants. These predicted incident case numbers generate good or substantial statistical power for a range of nested case-control studies of potential genetic, lifestyle and environmental determinants of disease. ...
Sex differences in human brain structure and function are of substantial scientific interest because of sex-differential susceptibility to psychiatric disorders and because of the potential to explain sex differences in psychological traits. Males are known to have larger brain volumes, though the patterns of differences across brain subregions have typically only been examined in small, inconsistent studies. In addition, despite common findings of greater male variability in traits like intelligence, personality, and physical performance, variance differences in the brain have received little attention. Here we report the largest single-sample study of structural and functional sex differences in the human brain to date (2,750 female and 2,466 male participants aged 44-77 years). Males had higher cortical and sub-cortical volumes, cortical surface areas, and white matter diffusion directionality; females had thicker cortices and higher white matter tract complexity. Considerable overlap between ...
In our study, the first to examine the relationship between PA and LV trabeculation extent in a community-based cohort using CMR imaging, the following observations were made. First, there was no linear relationship between PA and maximal NC/C ratio for both PA measurement methods. Second, there was no significant difference in maximal NC/C ratio between the lowest and highest PA extreme groups for both PA measurement methods. Third, PA (measured in total MET-min/week) augmented the negative relationship between LVEF and maximal NC/C ratio. Finally, age and LVEDV exhibited a significantly positive linear relationship with maximal NC/C ratio, while male sex, BMI, LV mass and LVEF exhibited a significantly negative linear relationship with maximal NC/C ratio.. Studies that previously hypothesised that LV trabeculation extent may participate in the exercise-induced cardiac remodelling process using models of pregnancy and extreme athletically trained PA levels found increased trabeculation extent ...
For innovative biomedical research scientists need high-quality biomaterials such as blood, urine and tissue samples and treatment data. The biobank service not only includes all steps of the processing chain from surgery to storage but also includes services covering many aspects of tissues such as histology, immunphenotyping, RNA/DNA extraction and all steps of quality control. A major focus is the handling and storage of fresh tumor tissues. The Charité Biobank ZeBanC provides a total number of 2.5 Mill FFPE samples (10,000 cancer patients/per year = 100,000 FFPE samples per year) and 100,000 fresh frozen samples. With the joint biobank, in which Charité and BIH invest a total of 3.9 million euros, better conditions for successful, independent and internationally competitive translational research will be provided. The new biobank building will be located at the Charité Campus and completed by April 2016. Charité is also the host for the BMBF-funded German Biobank Node (GBN) and acts via ...
Research Manager is a database for health research projects including biobanks at Health, Aarhus University. It helps researchers organize and share with collaborators all data about a research project. Furthermore, it can be used for research dating, that is, for collaboration about biobank samples and research methods. Login to Research Manager is with your AU ID username and password. Help texts are available in the menu to the left. We welcome suggestions for new topics, please contact us at [email protected] Help pages still in preparation will be clearly marked. We apologize for any inconvenience this may cause. Read more about Research Manager: A tool to manage research projects Which information can be registered? ...
The AIDS Specimen Bank (ASB) Core provides expertly collected and cryopreserved biological specimens, linked to detailed clinical information to enable multidis...
DARPA STTR 12.B Topic Descriptions. ST12B-001 TITLE: Advanced Materials and Methods for Biospecimen Collection for Infectious. Disease. TECHNOLOGY AREAS: Biomedical. OBJECTIVE: Develop advanced materials and technologies for swab or swab-like collection of biospecimens that can be used by a minimally-trained individual, can be shipped/stored under ambient conditions, and provide high efficiency recovery of analytes from the material. Desired technologies would advance methods to collect biospecimens, such as naso/oropharyngeal swabs, for the diagnosis of appropriate respiratory diseases. Developed swabs should be optimized for biospecimen collection and recovery with materials that maintain and preserve activity of viral or bacterial targets, while reducing the need for cold chain requirements (e.g., compatible with ambient temperature transport and storage). Swab designs that maintain sample collection efficiency, while decreasing the complexity or patient discomfort in the collection process ...
In eMERGE Phase I (September 2007 - July 2011), each participating institution led studies of the relationship between genetic variation and at least two common human traits among the network participants. Sites also explored the ethical and social issues associated with large-scale genomic research.. The Northwestern eMERGE team led the implementation of diabetes, asthma, lipids and several other phenotype algorithms. During Phase I, investigators successfully analyzed genome-wide association study (GWAS) data to discover new and validate known genetic associations with type II diabetes and height in African-Americans. The NUgene Project biobank, Northwesterns hospital-based biorepository, served as the source of DNA samples and data used for the eMERGE studies. The Northwestern team also led studies on the public perception of participation in genetic research and data sharing of genomic research results and the understanding of IRB professionals of data sharing for genomic research. In Phase ...
For the patient, there is a dangerous potential for incorrect treatment if that treatment is based on flawed biomarkers.. "HER2 is a powerful example of this," Dr. Compton said. "The decision to give Herceptin to a patient is entirely dependent on the result of the assay on the biospecimen without any other clinical information or input from any other source.. "So therapy is directly linked to a diagnostic test, and if you get either a false-positive or a false-negative [on HER2 status]-which we learned happened until recently about 20% of the time-you are subjecting a patient to a very expensive therapy that may not have any effect on their tumor.". Alternately, an incorrect diagnostic test on a biospecimen may result in withholding a potentially lifesaving therapy from a patient who merits it, she said.. "The effects on outcomes in the research world-the Journal of Irreproducible Results-are rife with these, while the misinterpretation of artifacts as biomarkers is already rampant in our ...
The ARLG biorepositories were created to aid in the development and evaluation of novel diagnostic tests and laboratory techniques, study mechanisms of resistance, generate preliminary data for study concepts, and support/mentor early-stage investigators pursuing research in the field of antibact. ...
The ARLG biorepositories were created to aid in the development and evaluation of novel diagnostic tests and laboratory techniques, study mechanisms of resistance, generate preliminary data for study concepts, and support/mentor early-stage investigators pursuing research in the field of antibact. ...
Dr. Lifshitz is the Director of the Translational Neurotrauma Research Program through the College of Medicine - Phoenix, which brings together clinicians and scientists as faculty to address the pathophysiology and recovery from animal models of acquired neurological injury (e.g. stroke, hemorrhage, concussion). These studies are guided by gaps in clinical knowledge to empower healthcare providers to improve quality of life for survivors. To this end, they use public databases, biorepositories, and animal models to address questions across the lifespan. Specific strengths include inflammation, rehabilitation, puberty, sleep, and neuronal morphology ...
INSTRUCTIONS: To answer a question, click the button in front of your choice. A response will appear in the window below the question to let you know if you are correct. Be sure to read the feedback. It is designed to help you learn the material. You can also learn by reading the feedback for incorrect answers. ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Research Using Subjects From The Type 1 Diabetes TrialNet Natural History Study (Living Biobank) (DP3) PAR-11-349. NIDDK
Press releases - The first journal to provide a unifying forum for the peer-reviewed communication of recent advances in the emerging and evolving field of biospecimen procurement, processing, preservation, and banking.
The purpose of the biobank is to enable future genomic based research on this Head and Neck Cancer patient population. The investigators will try to ide
Setting up the scientific and clinical infrastructure within a single-institution biobank to support research into personalized medicine requires standardization and consistency.
Biorepository Core in the Moores Cancer Center is a developing collection of plasma, serum, RNA stabilized buffy coat, urine, viable tumor samples, and formalin-fixed paraffin-embedded tumor; with associated clinical information. The tumor collection is predominately from breast and gastrointestinal malignancies. The core can provide anonymized samples from the repository, or ongoing sample collection.. Gene Transfer, Targeting and Therapeutics Core (GT3) in the Salk Institute Cancer Center GT3 (formerly called the Viral Vectors core) provides expert consultation for the safe and effective use of viral vector technologies, and offer custom design and production services for multiple viral vector types. The core supports production of custom lentiviral, retroviral, rAAV, G-deleted rabies, and adenoviral vectors.. The Chemical Library Screening core in the Sanford Burnham Prebys Medical Discovery Institute is also a part of the C3 collaborative agreement. The core includes: the Assay Development ...
A critical component of BioFIND is the standardized, longitudinal collection of biospecimens, which include plasma, blood, urine, saliva, cerebrospinal fluid (CSF), DNA and RNA. Investigators interested in incorporating BioFIND samples in their biomarker research can review an inventory of the available biospecimens by visiting the NINDS Repository at Coriell. Clinical data and biospecimens from BioFIND are now available for request. To request access to available BioFIND samples, please visit the National Institue of Neurological Disorders and Stroke, or email [email protected] for additional information. ...
Gatidis et al. discuss existing epidemiological imaging studies and the challenges that population imaging poses to big data research and biobanking.
Dr Seth champions the first and largest study of its kind on the genetics of ALD funded by the NIH/NIAAA under the multinational GenomALC Consortium (www.genomalc.org). Recruitment of thousands of drinkers at multiple sites across Australia, USA, UK, Germany, France and Switzerland is ongoing. The DNA from 5000 participants will be used for genotyping single nucleotide polymorphisms (SNPs) in a genome-wide association (GWA) approach. Under her direction the study has built a valuable and unique resource of over 2600 patients drinking history and other well characterised phenotype data, as well as linked clinical specimens for the GenomALC biorepository. This study has been successful in producing 5 publications, 10 presentations, 2 symposia and several media releases.. Dr Seth leads another concurrent international Australia India Stratgic Research Fund (AISRF) project investigating the angiogenic and immunomodulatory role of bone-marrow (BM) derived endothelial progenitor cells (EPCs) in liver ...
BioServes Global BioRepository provides leading academic and industry researchers with access to over 600,000 human DNA, tissue and serum samples linked to detailed clinical and demographic data from 120,000 consented and anonymized patients on four continents.. ...
Inflammatory bowel disease microbiome biorepository of well-defined studies or patient groups that will allow longitudinal sampling and analysis of the same microbiome species over the course of treatment, progression, or clinical ...
Once the sample reaches -50°C it is then moved from the CRF and is placed in an unique location for storage. It can then be independently retrieved without compromising other samples cell ...
GENEWIZ can characterize samples for identity and stability from preclinical stages through the manufacturing pipeline. We utilize validated methods according to ICH Q2 guidelines to support analysis of your monoclonal antibody therapeutics, immunotherapeutics, viral vectors, vaccines, and agricultural products.. Simply provide your master cell bank (MCB), working cell bank (WCB), viral particles, viral vector, master virus stock (MVS), gDNA, mRNA, plasmids or PCR products. GENEWIZ will design, develop, and optimize assays to verify identity and stability. Our experienced scientists and Quality Assurance Unit ensure that your samples are processed and results reported according to applicable regulatory standards to support IND, NDA, ANDA and BLA applications.. ...
NCRM N I C H E is a day of commemorative events to celebrate the Birth Anniversary of Nichi-In Centre for Regenerative Medicine, conducted every year in the month of October in Chennai,India.
Master Cell bank (MCB) and Working Cell Bank (WCB) generation for clinical trials at International Quality standards. Fill and Finish capability. Isolator based GMP cell production keeps costs low while maximising product safety and quality.
With new data from 23andMe and the UK Biobank, the GIANT Consortium is expanding opportunities to understand the genetics and biology of height and obesity.
RESULTS 347,130 UK Biobank participants with full data available (mean age 55.9 years, BMI 27.2 kg/m2, 54.2% women) were included in the analysis, of which 13,373 (4.0%) had diabetes. Over a median follow-up of 4.9 years (range 3.3-7.8 years), 6,209 died (594 as a result of CVD), and 4,301 developed CVD. Participants with diabetes were at higher risk of all-cause and CVD mortality and CVD incidence. Significant interactions (P , 0.05) existed whereby the risk of CVD mortality was higher in participants with diabetes with low (hazard ratio [HR] 4.05 [95% CI 2.72, 5.80]) versus high (HR 1.46 [0.87, 2.46]) grip strength. Similar results were observed for all-cause mortality and CVD incidence. ...
Author summary We develop a new method, MultiXcan, to test the mediating role of gene expression variation on complex traits, integrating information available across multiple tissue studies. We show this approach has higher power than traditional single-tissue methods. We extend this method to use only summary-statistics from public GWAS. We apply these methods to 222 complex traits available in the UK Biobank cohort, and 109 complex traits from public GWAS and discuss the findings.
Ninety per cent of the human population has been right-handed since the Paleolithic, yet the brain signature and genetic basis of handedness remain poorly characterized. Here, we correlated brain imaging phenotypes from ∼9000 UK Biobank participants with handedness, and with loci found significantly …
This deposit provides full details of the genome wide association stuy (GWAS) pipeline developed by the MRC-IEU for the full UK Biobank (July 2017) genetic data. For any issues ...
Danny Mitry; Kris Zutis; Baljean Dhillon; Tunde Peto; Shabina Hayat; Kay-Tee Khaw; James E. Morgan; Wendy Moncur; Emanuele Trucco; Paul J. Foster; 1 for the UK Biobank Eye and Vision ...
Danny Mitry; Kris Zutis; Baljean Dhillon; Tunde Peto; Shabina Hayat; Kay-Tee Khaw; James E. Morgan; Wendy Moncur; Emanuele Trucco; Paul J. Foster; 1 for the UK Biobank Eye and Vision ...
The concept of molecularly directed medicine has long been cogent, elegant, and appealing, but it never could have been realized without the stunning technology development that has made it possible to generate and analyze colossal amounts of molecular analysis data rapidly, efficiently, and accurately. Advances in biomolecular analysis technologies and information technologies have transformed both the biomedical sciences and the practice of medicine. These technologies have provided unprecedented power to probe disease pathobiology, uncover meaningful associations amid vast data sets, and provide new insights into the functional significance of molecular characteristics. Thanks to these technologies, the amount of clinically meaningful and biologically significant data that can be generated from patient biospecimens has increased by orders of magnitude.. The power of these sophisticated analysis platforms, however, has raised the biomolecular quality bar for the biospecimens that are the ...
In 2012, the College accredited RUDCR through its Biorepository Accreditation Program, making the operation at Rutgers one of the first in the world to earn this designation.. The program is intended to improve and validate the quality of biospecimens and biorepositories. It focuses on standardizing and improving the collection, processing, storage, and distribution of biospecimens, along with computerizing associated information. The program also is intended to ensure the quality of human specimens (e.g., blood, serum, saliva, tissue) and the genetic materials derived from them (e.g., DNA, RNA).. "Were extremely pleased by this strong validation of our shared commitment to the highest levels of quality and service to the biomedical research community," said Jay A. Tischfield, Founder and Chief Executive Officer of RUCDR, Duncan and Nancy Macmillan Professor of Genetics, and Director of the Human Genetics Institute of New Jersey. "There are thousands of biorepositories in the world, with a wide ...
Results from this study are consistent with the findings from other empirical research that there is a high level of public support for biomedical research and willingness to donate HBSs for this purpose.3-5 ,7 ,17-19 However, by presenting participants with scenarios consisting of a variety of HBS types across a number of settings, and by using qualitative as well as quantitative methods, we have been able to build a richer understanding of public attitudes. While it is important to bear in mind that the opinions expressed are hypothetical and therefore do not necessarily correspond with how people would actually behave in practice, they still offer an intriguing insight into public attitudes which can help inform policy and practice.. The general willingness of the UK public to donate residual HBSs is consistent with findings from other studies conducted in the UK, the USA and Scandinavia where willingness to donate varied from 67% to 88%.3-5 ,7 ,17 ,18 Interestingly, people who themselves had ...
Aims: This study aimed to investigate the effects of long-term exposure to road traffic noise on incident CVD in three large cohorts: HUNT, EPIC-Oxford and UK Biobank. Methods: In a complete-case sample (N=361,699), 4,014 IHD and 2,109 cerebrovascular incident cases were ascertained between baseline (1993-2010) and end of follow-up (2008- 2015) through medical record linkage. Annual mean road traffic noise exposure was modelled at baseline address. Individual-level covariate data were harmonised and data were pooled. Analyses used Cox proportional hazards model with adjustments for confounders, including air pollution. Results: For an interquartile range (IQR) (3.9 dBA) higher daytime noise, a non-significant association with incident IHD was seen (Hazard ratio (HR): 1.015, 95% Confidence Interval (CI): 0.989-1.042), fully adjusted. Statistically significant associations and interaction terms were seen in obese individuals (HR: 1.099, 95%CI: 1.029-1.174), and current-smokers (HR: 1.054, 95%CI: ...
The ability to undertake controlled human malaria infection (CHMI) studies for preliminary evaluation of malaria vaccine candidates and anti-malaria drug efficacy has been limited by the need for access to sporozoite infected mosquitoes, aseptic, purified, cryopreserved sporozoites or blood-stage malaria parasites derived ex vivo from malaria infected individuals. Three different strategies are described for the manufacture of clinical grade cultured malaria cell banks suitable for use in CHMI studies. Good Manufacturing Practices (GMP)-grade Plasmodium falciparum NF54, clinically isolated 3D7, and research-grade P. falciparum 7G8 blood-stage malaria parasites were cultured separately in GMP-compliant facilities using screened blood components and then cryopreserved to produce three P. falciparum blood-stage malaria cell banks. These cell banks were evaluated according to specific criteria (parasitaemia, identity, viability, sterility, presence of endotoxin, presence of mycoplasma or other viral agents
Dr. Swati Goels research focuses on patients with blood disorders and blood-related cancers. Dr. Swati Goel specializes in the field of myeloproliferative disorders like myelofibrosis, polycythemia vera, and essential thrombocytosis. She is the leader of Myeloproliferative Disorder Clinical Trial Program at Montefiore Medical Center and Albert Einstein College of Medicine.She is actively recruiting patients in various clinical trials in these diseases for treatment. She is also a co-investigator in Hematology Biobank protocol which acts as the biorepository for various hematological disorders.. ...
Introduction. Contents 1. Introduction 2. Summary 3. What are stem cells? 3.1 Adult stem cells 3.2 Core blood stem cells 3.3 Embryonic stem cells 4. Potentially of embryonic stem cells 5. UK Stem Cell bank. 6. Controversial Issues 7. Bibliography 1. Introduction This is a report on stem cells and the stem cell bank The aim of this report to overview stem cell research, including stem cell banks and pitched at general readers of non scientific background. 2 Summary This report consists of brief information on what stem cells are and their sources, the UK Stem Cell Bank and the controversy surrounding embryonic stem cell research. The main point of this report is the potential for treatment of illness using embryonic stem cells. 3. What are Stem Cells? Stem cells are unspecialized (cells of no particular function) that reproduce themselves continually and under the right conditions develop from simple to more complex cells which are specialized to perform particular functions, this is termed cell ...
Sir Richard Branson has launched a new company under his Virgin brand which will offer umbilical cord blood banking facilities to parents of newborn babies. Cord blood transfusions are already used for the treatment of blood related disorders but some believe that umbilical cord blood, which is rich in stem cells, may have some future potential to treat diseases such as Parkinsons and diabetes. The expectation behind private cord blood banking is that the individuals whose blood is stored might benefit in the future should stem cell treatments became available to treat such conditions.. Private companies offering umbilical cord blood banking facilities to parents already exist in the UK, but Virgins Health bank will develop a novel approach by splitting each collection and donating part of it for the treatment of others. Sir Richard said, we will take an individuals cord blood and we will divide it into two. Part of it will go into a national blood centre that anyone can get access to and ...
Background. Commonly tested Loss-of-function (LOF) alleles in CYP2C19 are present in 30-40% of patients who experience stent thrombosis. The objective of this study was to identify novel genetic variants in CYP2C19 gene associated with stent thrombosis.. Methods. We included 70 patients with definite stent thrombosis while on clopidogrel who had stored DNA samples in our institutional (n=12) or PLATO trial (n=70) biorepository. Cases were matched 1:1 with controls for age, race, sex, diabetes, type of stent, and presentation. All controls were on clopidogrel and free of recurrent events. Clinical Pharmacogenetics (PGx) Implementation Consortium (CPIC) guidelines were used to determine the list of known PGx variants and dbSNP version 142 was used to assess novel variants. Whole exome sequencing was performed using the protocol for Agilents SureSelect Human All Exon v5 + UTRs 75 MB kit and additional custom primers were designed to cover the entire CYP2C19 gene.. Results. Mean age was 63 ± 12 ...
Dr. Dawson is chair of the Observational Studies Monitoring Board of the NIA-funded Longevity Consortium and a member of the NIDCR Data Safety and Monitoring Board, Adult Caries Prevention Trial. She also serves on the NIDCR Protocol Review Committee for the Dental Practice Based Research Networks and three external scientific advisory boards for NIH-supported research. She is a core member of the Clinical Trials Special Emphasis Panels sponsored by the National Institute of Dental and Craniofacial Research. She has served on the Clinical Aging Study Section of the National Institute on Aging (NIH). Past service includes appointments to the Cooperative Studies Evaluation Committee for the Health Services Research and Development Service, Veterans Health Administration Research Program, Department of Veterans Affairs, Washington, D.C. (1997-2004); the Veterans Affairs Biorepository Project Planning Committee (2001-2003); and the DNA Bank Scientific Advisory Committee for the VA Cooperative ...

Core Facilities - School of Public Health and Health Professions - University at BuffaloCore Facilities - School of Public Health and Health Professions - University at Buffalo

Biological Specimen Bank. This facility houses specimens collected as part of the departments epidemiological studies and ... The EEH specimen bank currently houses about 700,000 samples from approximately 20,000 participants. ... The specimens are stored either in -80°C freezers and in cryogenic containers, or immersed in liquid nitrogen (-196 °C). A ... biological and radiological agents. We do this by improving knowledge and understanding of the physiological stresses that ...
more infohttp://sphhp.buffalo.edu/home/research/core-facilities.html

Plus itPlus it

Biological specimen banks. *informed consent. *research subjects. *confidentiality. *trust. Introduction. Biorepositories are ... The application of molecular technologies to collections of human biological specimens represents an unparalleled opportunity ... Efforts to compile health information and collect biological specimens from large populations are already under way in the ... As one stated: "Its kind of like a blood bank except that its not for people who need blood to live, its for people who need ...
more infohttp://cebp.aacrjournals.org/content/17/6/1440

Saúde Pública - Biobanking for health research in Brazil: present challenges and future directions Biobanking for health...Saúde Pública - Biobanking for health research in Brazil: present challenges and future directions Biobanking for health...

Keywords: biological specimen banks; ethics, research; informed consent; health research policy; incidental findings; Brazil. ... Cell Tissue Bank. 2007;8(4):287-95. 16. McNelly E, Cambon-Thomsen A. Twenty-five recommendations on the ethical, legal, and ... f) Steps will be taken to ensure anonymity in any form of disclosure of information derived from the use of his/her biological ... a) Biological human samples are sent to other countries for experiments that cannot be performed locally. ...
more infohttps://scielosp.org/scielo.php?script=sci_abstract&pid=S1020-49892012000600012&lng=es&nrm=iso&tlng=es

Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)

Categories: Biological Specimen Banks Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
more infohttps://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Biological+Specimen+Banks&parentid=12249&catid=32967

Human Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide. - NextBio articleHuman Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide. - NextBio article

Biological Specimen Banks Carcinoma, Squamous Cell Case-Control Studies Continental Population Groups DNA-Binding Proteins ... providing a comprehensive reference for phylogenetic classification of HPV18 sublineages for epidemiological and biological ...
more infohttp://www.nextbio.com/b/search/article.nb?id=26269181

Chapter 26|HuGE 2010|Books|Resources|Genomics|CDCChapter 26|HuGE 2010|Books|Resources|Genomics|CDC

Nørgaard-Pedersen B, Simonsen H. Biological specimen banks in neonatal screening. Acta Paediatr Suppl. 1999;88(432):106-109. ... along with a matched sample of control specimens. Ideally, specimens should be retrieved for all children who died in infancy ... linked 32 specimens positive for CH by thyroid stimulating hormone (TSH) screening to childrens records, and 31 of these ... If the primary endpoint for a disorder is mortality, a less expensive alternative is to link stored blood spot specimens with ...
more infohttps://www.cdc.gov/genomics/resources/books/2010_HuGE/chap26.htm

Bland and Altman plot of both measurements of number id | Open-iBland and Altman plot of both measurements of number id | Open-i

Biological Specimen Banks. *Databases, Factual. *Humans. *Sensitivity and Specificity. Related in: MedlinePlus ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4220929_pone.0110289.g004&req=4

Biobankinganforderungen aus Sicht des Klinikers | Springer for Research & DevelopmentBiobankinganforderungen aus Sicht des Klinikers | Springer for Research & Development

Biological specimen banks Biomedical research Clinical medicine Clinical trial Clinical registries This is a preview of ...
more infohttps://rd.springer.com/article/10.1007/s00292-018-0434-x

EUROGIN 2019 : OFFICIAL WEBSITEEUROGIN 2019 : OFFICIAL WEBSITE

1994 Founder, Nordic Biological Specimen Banks on Cancer Causes&Control (NBSBCCC). 2000- PI, Clinical trials in ,50 000 ...
more infohttps://www.eurogin.com/2019/

Monitoring Environmental Materials and Specimen Banking : Proceedings of the International Workshop, Berlin (West), 23-28...Monitoring Environmental Materials and Specimen Banking : Proceedings of the International Workshop, Berlin (West), 23-28...

Monitoring Environmental Materials and Specimen Banking : Proceedings of the International Workshop, Berlin (West), 23-28 ... State-of-the-art of biological specimen banking in the Federal Republic of Germany.- Ecological action of mercury by-products ... Use of oysters and related molluscs as biological monitors of synthetic organic pollutants.- Specimen banking marine organisms ... Experiences in monitoring and banking human biological specimen.- Organohalogenated compounds in plants and soil.- Terrestrial ...
more infohttp://www.worldcat.org/title/monitoring-environmental-materials-and-specimen-banking-proceedings-of-the-international-workshop-berlin-west-23-28-october-1978/oclc/840307092

China suboptimal health cohort study: rationale, design and baseline characteristics | Journal of Translational Medicine | Full...China suboptimal health cohort study: rationale, design and baseline characteristics | Journal of Translational Medicine | Full...

Haematology, biochemistry and biological specimen banking in the COACS. Analysate. Red blood cells ... Continuous collection of multiple biomarkers, together with banking of biological samples (serum, plasma, DNA and RNA) will ... Blood samples were processed and separated onsite for biospecimen banking (−80 °C). DNA and RNA were extracted and stored in ... lack of biological samples to measure biomarkers [24, 25], or limited definite information on environmental exposures and ...
more infohttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1046-y

Empty Backbone Plasmids at Addgene. The number of backb | Open-iEmpty Backbone Plasmids at Addgene. The number of backb | Open-i

Biological Specimen Banks. *Gene Library. *Genetic Vectors. *Internet. © Copyright Policy - creative-commons Related In: ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4384007_gku893fig2&req=4

Search of: Genital Diseases, Female - List Results - ClinicalTrials.govSearch of: 'Genital Diseases, Female' - List Results - ClinicalTrials.gov

Tissue Bank of Biological Specimens From Patients With Gynecologic Disease. *Endometrial Neoplasms ... progression-free survival according to RECIST 1.1 and cancer antigen 125 (CA 125) (for ovarian cancer) (biological progression- ... Biological: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 20/40/40/20 ... Biological: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 40/40/40/40 ...
more infohttps://clinicaltrials.gov/ct2/results?cond=%22Genital+Diseases%2C+Female%22&show_rss=Y&sel_rss=mod14

Search Results -   - 11 Results - The Portal to Texas HistorySearch Results - - 11 Results - The Portal to Texas History

... biological specimen banks, and cell preservation. The interview continues with a discussion of his sentiments regarding the re- ...
more infohttps://texashistory.unt.edu/explore/collections/THC/browse/?fq=dc_type%3Asound&display=list

WHO HQ Library catalog ›  MARC details for record no. 40924WHO HQ Library catalog › MARC details for record no. 40924

Biological Specimen Banks. General subdivision. Standards. --. Organization & Administration. --. Methods. 650 02 - SUBJECT ...
more infohttps://kohahq.searo.who.int/cgi-bin/koha/opac-MARCdetail.pl?biblionumber=40924

sg:pub.10.1038/ejcn.2017.43 - Springer Nature SciGraphsg:pub.10.1038/ejcn.2017.43 - Springer Nature SciGraph

"Biological Specimen Banks", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "Biomarkers ... Knowledge of biological pathways implicated in FLD is limited. An untargeted metabolomic approach might unravel novel pathways ... Knowledge of biological pathways implicated in FLD is limited. An untargeted metabolomic approach might unravel novel pathways ... Knowledge of biological pathways implicated in FLD is limited. An untargeted metabolomic approach might unravel novel pathways ...
more infohttps://scigraph.springernature.com/pub.10.1038/ejcn.2017.43

Bring on the biomarkers<...Bring on the biomarkers<...

Biological Specimen Banks Specimen Handling Precision Medicine Pharmacogenetics Medical Genetics Gene Expression Profiling ...
more infohttps://asu.pure.elsevier.com/en/publications/bring-on-the-biomarkers

The Malmö biological bank.  - PubMed - NCBIThe Malmö biological bank. - PubMed - NCBI

... there is high scientific value in banking biological specimens for future use in the Malmö Diet and Cancer Study. The banking ... The Malmö biological bank.. Pero RW1, Olsson A, Berglund G, Janzon L, Larsson SA, Elmståhl S. ... It is hoped that these banking procedures will encourage a high activity in biomarker development in the future. ... Currently there are no available biological markers that have been satisfactorily validated clinically as intermediate end- ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8429289?dopt=Abstract

WHO | In this months <em...WHO | In this month's <em...

Banks of biological specimens. Haidan Chen & Tikki Pang (113‒117) call for global governance of these collections. ...
more infohttp://origin.who.int/entity/bulletin/volumes/93/2/15-000215/en/

Where can I have dental implants in Croatia? - lookformedical.comWhere can I have dental implants in Croatia? - lookformedical.com

Biological Specimen Banks (0) * Birthing Centers (0) * Dental Facilities (2) * Dental Clinics (1) ...
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  • I thought you might be interested in this item at http://www.worldcat.org/oclc/840307092 Title: Monitoring Environmental Materials and Specimen Banking : Proceedings of the International Workshop, Berlin (West), 23-28 October 1978 Author: N -P Luepke Publisher: Dordrecht : Springer Netherlands, 1980. (worldcat.org)
  • Selection of environmental materials and specimens related to terrestrial ecosystems and pollutants or pollutant categories. (worldcat.org)
  • Efforts to compile health information and collect biological specimens from large populations are already under way in the United States and around the world ( 2 ), with the ultimate goal of unlocking the genomic basis of disease and ushering in an era of personalized medicine ( 3 ). (aacrjournals.org)