Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Laws concerned with manufacturing, dispensing, and marketing of drugs.
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
Infections with viruses of the genus PESTIVIRUS, family FLAVIVIRIDAE.
The presence of organisms, or any foreign material that makes a drug preparation impure.
The process of protecting various samples of biological material.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.
Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.
Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)

Changes of neonatal mortality rate between 'pre' and 'post' surfactant period. (1/1706)

The objective of this study was to determine how the neonatal mortality rate has changed since surfactant (S) therapy was introduced in our Neonatal Intensive Care Unit (NICU), and to evaluate the efficacy of surfactant therapy in respiratory distress syndrome (RDS) patients. Incidences of risk babies such as outborns, prematurity, low birth weight infants and RDS, and neonatal mortality rates were compared between 'pre' (control, 1988 to 1991, n=4,861) and 'post' S period (study, 1993 to 1996, n=5,430). In RDS patients of 'post' S period, neonatal mortality rate was compared between S-treated and non-treated patients, and chest X-ray and ventilatory parameters were compared between pre- and post-72 hr of surfactant treatment. Surfactant therapy showed short term effects, judging by the decrease of early neonatal deaths and improvement of chest X-ray and ventilatory parameters in RDS patients. The overall neonatal mortality rate had a tendency to decrease in spite of increased incidences of risk babies in 'post' S period but it was less than expected. The reasons were thought to be that we had a high proportion of risk babies, and there was some bias in patient selection for surfactant therapy and its use. In conclusion, with the active prevention of risk baby delivery and appropriate use of surfactant, better results could be expected.  (+info)

Surfactant treatment for acute respiratory distress syndrome. (2/1706)

OBJECTIVE: To determine prospectively the efficacy of surfactant in acute respiratory distress syndrome. STUDY DESIGN: Twenty patients, 1 month to 16 years of age, diagnosed with an acute pulmonary disease with severe hypoxaemia (PaO2/FiO2 < 100) (13 with systemic or pulmonary disease and seven with cardiac disease) were treated with one to six doses of 50-200 mg/kg of porcine surfactant administered directly into the trachea. The surfactant was considered to be effective when the PaO2/FiO2 improved by > 20%. RESULTS: After initial surfactant administration the PaO2/FiO2 increased significantly in patients with systemic or pulmonary disease from 68 to 111, and the oxygenation index (OI) diminished significantly from 36.9 to 27.1. The PaO2/FiO2 and OI did not improve in children with cardiac disease. The improvement of the patients who survived was greater than that of those who died. CONCLUSIONS: Surfactant moderately improves oxygenation in some children with severe acute respiratory distress syndrome secondary to pulmonary or systemic disease.  (+info)

Preclinical development strategies for novel gene therapeutic products. (3/1706)

With over 220 investigational new drug applications currently active, gene therapy represents one of the fastest growing areas in biotherapeutic research. Initially conceived for replacing defective genes in diseases such as cystic fibrosis or inborn errors of metabolism with genes encoding the normal, or wild-type, gene product, gene therapy has expanded into other novel applications such as treatment of cancer or cardiovascular disease, where the risk:benefit profiles may be more acceptable in relation to the severity of the disease. Different types of vectors, including modified retroviruses, adenoviruses, adenovirus-associated viruses, and herpesviruses and plasmid DNA, are used to transfer foreign genetic material into patients' cells or tissues. Developing a toxicology program to determine the safety of these agents, therefore, requires a modified approach that encompasses the pharmacology and toxicity of both the gene product itself and the vector system used for delivery in the context of the application for the clinical trial. In general, the issues involved in designing and developing appropriate preclinical testing to determine the safety of these products are similar to those encountered for other recombinant molecules, including protein biotherapeutics. Limitations to some of the typical toxicology studies conducted for a traditional drug development program may exist for these agents, and nontraditional approaches may be required to demonstrate their safety. Many factors may affect the safety and clinical activity of these agents, including the route, frequency, and duration of exposure and the type of vector employed. Other safety considerations include quantitation of the duration and degree of expression of the vector in target and other tissues, the effects of gene expression on organ pathology and/or histology, evaluation of trafficking of gene-transduced cells or vector after injection, and interactions of the host immune system with the transduced cell population. Because of the unique concerns regarding each of these therapies, the Center for Biologics Evaluation and Research encourages sponsors to obtain toxicity data whenever possible while evaluating the pharmacologic activity of the vector in a species or animal model relevant to their clinical indication. Sponsors are encouraged to discuss preclinical study design and results with the Center during product development to facilitate early identification of safety concerns prior to entry of these novel agents into the clinical setting and to ensure an uninterrupted course of development while addressing issues required for licensure.  (+info)

Regulatory decision strategy for entry of a novel biological therapeutic with a clinically unmonitorable toxicity into clinical trials: pre-IND meetings and a case example. (4/1706)

The following material was derived from a synthesis of case histories taken from investigational new drug (IND) applications and drug sponsors' experiences, utilizing fictionalized data to avoid any resemblance to any proprietary information; any such resemblance is accidental. These examples are used as an instructional scenario to illustrate appropriate handling of a difficult toxicology issue. In this scenario, a drug caused a toxicity in animals that was detected only by histopathologic analysis; if it were to develop in patients, no conventional clinical methods could be identified to monitor for it. It is not unusual for a firm to cancel clinical development plans for a lead drug candidate that causes such a toxicity, especially if such a drug is intended for use as a chronic therapeutic in a population of patients with a chronic disease. This case synthesis was inspired by a Food and Drug Administration (FDA) agreement to allow such a product to proceed into clinical trials after substantive pre-IND discussions and agreement on well-considered toxicology program designs. The scientists most closely involved in the strategy development included the sponsor's toxicologist, veterinary toxicologic pathologist, and pharmacokineticist, as well as the FDA's reviewing pharmacologist. The basis of this decision was thorough toxicity characterization (1-month studies in 2 species); correlating toxicities with a particular cumulative area under the curve (AUC) in both species; identification of the most sensitive species (the species that showed the lower AUC correlating with toxicity); allometric assessment of clearance of the drug in 3 nonhuman species; construction of a model of human kinetics (based on extrapolation from animal kinetics); and finally, estimation of clinical safety factors (ratios of the human estimated cumulative AUC at the proposed clinical doses, over the animal cumulative AUC that correlated with the no adverse effect levels). Industry and FDA scientists negotiated a joint assessment of risk and benefit in patients, resulting in the FDA permitting such a compound to enter into clinical trials for a serious autoimmune disease. Such constructive, early communication starts with the pre-IND meeting, and the conduct and planning for this meeting can be very important in establishing smooth scientific and regulatory groundwork for the future of a drug under IND investigation.  (+info)

Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond. (5/1706)

Many scientific discussions, especially in the past 8 yr, have focused on definition of criteria for the optimal assessment of the preclinical toxicity of pharmaceuticals. With the current overlap of responsibility among centers within the Food and Drug Administration (FDA), uniformity of testing standards, when appropriate, would be desirable. These discussions have extended beyond the boundaries of the FDA and have culminated in the acceptance of formalized, internationally recognized guidances. The work of the International Committee on Harmonisation (ICH) and the initiatives developed by the FDA are important because they (a) represent a consensus scientific opinion, (b) promote consistency, (c) improve the quality of the studies performed, (d) assist the public sector in determining what may be generally acceptable to prepare product development plans, and (e) provide guidance for the sponsors in the design of preclinical toxicity studies. Disadvantages associated with such initiatives include (a) the establishment of a historical database that is difficult to relinquish, (b) the promotion of a check-the-box approach, i.e., a tendancy to perform only the minimum evaluation required by the guidelines, (c) the creation of a disincentive for industry to develop and validate new models, and (d) the creation of state-of-the-art guidances that may not allow for appropriate evaluation of novel therapies. The introduction of biotechnology-derived pharmaceuticals for clinical use has often required the application of unique approaches to assessing their safety in preclinical studies. There is much diversity among these products, which include the gene and cellular therapies, monoclonal antibodies, human-derived recombinant regulatory proteins, blood products, and vaccines. For many of the biological therapies, there will be unique product issues that may require specific modifications to protocol design and may raise additional safety concerns (e.g., immunogenicity). Guidances concerning the design of preclinical studies for such therapies are generally based on the clinical indication. Risk versus benefit decisions are made with an understanding of the nature of the patient population, the severity of disease, and the availability of alternative therapies. Key components of protocol design for preclinical studies addressing the risks of these agents include (a) a safe starting dose in humans, (b) identification of potential target organs, (c) identification of clinical parameters that should be monitored in humans, and (d) identification of at-risk populations. One of the distinct aspects of the safety evaluation of biotechnology-derived pharmaceuticals is the use of relevant and often nontraditional species and the use of animal models of disease in preclinical safety evaluation. Extensive contributions were made by the Center for Biologics Evaluation and Research to the ICH document on the safety of biotherapeutics, which is intended to provide worldwide guidance for a framework approach to the design and review of preclinical programs. Rational, scientifically sound study design and early identification of the potential safety concerns that may be anticipated in the clinical trial can result in preclinical data that facilitate use of these novel therapies for use in humans without duplication of effort or the unnecessary use of animals.  (+info)

Are there environmental forms of systemic autoimmune diseases? (6/1706)

A large number of drugs and an increasing number of environmental agents reportedly result in the appearance of a number of autoantibodies and in many instances in the appearance of a range of autoimmune clinical syndromes. The major disorders so recognized have marked resemblances to the autoimmune disease systemic lupus erythematosus. The commonly used term is drug-induced lupus; a better term is drug-related lupus. There is considerable interest at the present time in an increasing number of environmental agents. There have been two epidemics in recent years--one in Spain to a contaminant of rapeseed oil and one in the United States to a contaminant of l-tryptophan that caused an eosinophilic myositis. It is important for physicians and others involved in health care to recognize the potential associations of these diseases of unknown cause or causes.  (+info)

The role of the toxicologic pathologist in the preclinical safety evaluation of biotechnology-derived pharmaceuticals. (7/1706)

Biotechnology-derived pharmaceuticals, or biopharmaceuticals, represent a special class of complex, high molecular weight products, such as monoclonal antibodies, recombinant proteins, and nucleic acids. With these compounds, it is not appropriate to follow conventional safety testing programs, and the preclinical "package" for each biopharmaceutical needs to be individually designed. In addition to standard histopathology, the use of molecular pathology techniques is often required either in conventional animal studies or in in vitro tests. In this review, the safety evaluation of biopharmaceuticals is discussed from the perspective of the toxicologic pathologist, and appropriate examples are given of the use of molecular pathology procedures. Examples include the use of in situ hybridization to localize gene therapy vectors, the assessment of vector integration into genomic DNA by the polymerase chain reaction (PCR), and the use of immunohistochemistry to evaluate the potential cross-reactivity of monoclonal antibodies. In situ PCR techniques may allow for confirmation of the germ cell localization of nucleic acids and may therefore facilitate the risk assessment of germline transmission. Increased involvement with biopharmaceuticals will present challenging opportunities for the toxicologic pathologist and will allow for much greater use of molecular techniques, which have a critical role in the preclinical development of these compounds.  (+info)

Structures of surfactant films: a scanning force microscopy study. (8/1706)

The alveolar lining layer is thought to consist of a continuous duplex layer, i.e., an aqueous hypophase covered by a thin surfactant film which is a monolayer with dipalmitoyl-phosphatidylcholine (DPPC) as its most important component. Findings obtained by electron microscopy and results from in vitro experiments suggest, however, that the structure and hence the structure-function relations of surfactant films are more complex. In order to better define their structures films of surfactants were studied by scanning force microscopy. Four different surfactants were spread on a Langmuir-Wilhelmy balance, and then transferred onto a solid mica plate by the Langmuir-Blodgett technique, under various states of film compression. Imaging of the films by scanning force microscopy was performed in the contact (repulsive) mode in air. The scanning force micrographs revealed that surfactant films are not homogeneous, but rather undergo phase transitions depending on the surface pressures. Even at comparable surface pressures different surfactants show quite different surface patterns. Differences in surface structure can even be observed in films containing surfactant proteins (SP)-B and SP-C. These observations give further evidence that the widely accepted hypothesis of a regular monolayer of phospholipids governing the surface tension probably does not hold true, but that the structure-function relationship of surface active surfactant films is even more complex than hitherto thought.  (+info)

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Title:Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents. VOLUME: 16 ISSUE: 10. Author(s):Bin Yu, Yi-Chao Zheng, Xiao-Jing Shi, Ping-Ping Qi and Hong-Min Liu. Affiliation:School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, P. R. China.. Keywords:Anticancer agents, cancer therapy, MDM2 inhibitors, natural products, PLK4 inhibitors, spirooxindoles.. Abstract:The utility of natural products for identifying anticancer agents has been highly pursued in the last decades and over 100 drug molecules in clinic are natural products or natural product-derived compounds. Natural products are believed to be able to cover unexplored chemical space that is normally not occupied by commercially available molecule libraries. However, the low abundance and synthetic intractability of natural products have limited their applications in drug discovery. Recently, the identification ...
Pharmaceutical manufacturer Merck will donate its entire library of natural products to the Institute for Hepatitis and Virus Research along with a grant, the institute announced this week. The library, one of the worlds largest, will be open for researchers around the world.. This is an extraordinary opportunity for the Hepatitis B Foundation and our research institute, allowing us to make this treasure available to scientists from all over the world, Timothy Block, co-founder and president of the Hepatitis B Foundation and the IHVR, said in a press release. Block is also a professor of microbiology at Drexel University College of Medicine. The institute is located in Pennsylvania.. We will be able to create a screening center and provide access to this collection in a way that may lead to new discoveries and new companies in both Pennsylvania and New Jersey, he said.. The Merck (also known as MSD) natural products library is considered to be one of the most diverse and best curated ...
BioTek アプリケーションノート, 08/07 2012, Rapid Screening of a Cell-based Assay for GLP-1 Receptor Using a Natural Product Library
Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.
Im taking red yeast rice capsules to lower my cholesterol, and I noticed that some brands recommend taking it with food, while others dont. What should I do?. Take the red yeast rice supplement before you go to bed, whether your belly is full or not. Because the body naturally produces more cholesterol at night, youll wind up benefiting more from the supplement this way.. Theres no doubt that red yeast rice helps lower cholesterol. Like prescription statins, red yeast rice supplements work by blocking production of a liver enzyme that generates cholesterol. A UCLA School of Medicine study of 83 adults found that it lowered cholesterol levels by 16% in 8 weeks. Research in China involving thousands of people showed a 30% reduction in heart disease risk in those who took the supplement for 4 years.. Despite these benefits, statins may be a safer bet. The FDA doesnt regulate dietary supplements, so you may have a hard time selecting an effective red yeast product, while statins are FDA ...
Researchers at UCLA wondered whether red yeast rice might also be useful for preventing cancer. We know that lovastatin decreases blood cholesterol, but it also has an anti-inflammation effect, and inflammation is a primary risk factor in colon cancer development, explains Mee Young Hong, MD, who was a research fellow in the UCLA Center for Human Nutrition when she worked on the study, and is now assistant professor at San Diego State University. We thought that red yeast rice, which contains a natural source of lovastatin, might help with cancer prevention. Past research has found that cancerous tumors need cholesterol to grow, and studies have shown that people who take statins have a reduced risk of colon cancer.. Dr. Hong and her colleagues compared the effects of different Chinese red yeast rice formulations with the drug lovastatin on colon cancer cells in a laboratory.* The red yeast rice triggered tumor cell death, and it reduced tumor cell growth by as much as 41%--an even greater ...
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KALAMAZOO--Dr. Gunda I. Georg, an expert in medicinal chemistry, drug discovery and natural products chemistry, will deliver the 2012 Harmon Lecture at Western Michigan University from 4 to 5:15 p.m. Monday, April 9, in Room 1260 of the Chemistry Building.. Georg will address Natural Products as Leads for Anticancer Drug Discovery. The U.S. Food and Drug Administration has approved more than 1,000 new small molecule drugs in the past 30 years. Of the approved anticancer agents, 74 percent are natural product-derived. Thus, natural products continue to be an excellent source as drugs or leads for drug discovery efforts.. A reception will follow the lecture, which is open to the public free of charge.. Tuesday, April 10, from 11 a.m. to 12:15 p.m., Georg will speak on The Evolving Landscape for Drug Discovery Innovation, also in Room 1260 of the Chemistry Building. The second talk will provide an overview of the health care challenges in the future, including increases in world population, ...
The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically in recent decades. On the other hand, known compounds were re-discovered again and again, possibly from related producing organisms, making natural products discovery an expensive and time-consuming endeavor. Therefore, in recent years, efforts for discovering new natural products have been redirected towards organisms from unique and untapped areas of the globe with remarkable biodiversity potential and/or extreme environment, such as deep-sea vents, caves, and other unusual ecosystems. This dissertation describes our efforts to discover new bioactive natural products from microorganisms isolated from a unique black water ecosystem in Indonesia. Indonesia is recognized as a major ...
Thus, alternatives to the statins are often sought by people experiencing negative side effects. It should be noted that a recent study published in the Annals of Internal Medicine do support the use of red yeast rice, actually a by-product of cooked rice on which red yeast is grown. The study found that red yeast rice in supplement form was effective in patients who had been unable to take statin drugs because the drugs caused muscle problems. The study also found that that red yeast rice did not cause liver impairment (Garloch, 2010 ...
Link for Professor OConnor. Abstract: Plants, which make thousands of complex natural products, are outstanding chemists. Through the concerted action of enzymes that are assembled into metabolic pathways, nature creates chemical complexity from simple starting materials. I will highlight some of the unusual enzymatic transformations that plants use to make complex, bioactive natural products, and will also discuss methods by which these pathways can be harnessed for metabolic engineering. The focus is on the biosynthesis of the monoterpenes called iridoids, and the alkaloids derived from iridoids, known as the monoterpene indole alkaloids. The discovery, functional characterization and mechanistic study of enzymes involved in the biosynthesis of these important compounds in several medicinal plant species will be discussed.. ...
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Beyond Red Yeast Rice 60 Tablets Directions: As a dietary supplement, take 2 tablets daily, preferably with meals. Store in a cool, dry place. Caution: Do not take if you are pregnant or nursing. This product is not to be used by anyone under 20 years of age. Consult with your physician before using this product if you are taking any medication or if you are under physician supervision. Description:Red Yeast Rice contains beneficial unsaturated fatty acids (>125 mg/g) including mono- and polyunsaturated fatty acids, as well as proteins, amino acids and phytonutrients. All are elements of a healthy diet.Artichoke extract has flavonoid constituents that demonstrate antioxidant activity and are intended to provide nutritional support for healthy digestion.Guggul, a plant that has been used in traditional Ayurvedic medicine for centuries, is intended to provide nutritional support for healthy cardiac enzymes and heart function.Vitamin B-12, B6, and Folic Acid have been added and are intended to
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Description: The KAL brand offers this incredible combination of 600 mg Red Yeast Rice and 30 mg CoQ-10 in a base of 500 mg Omega 3 Fish Oil. This easy-to-swallow, once daily softgel provides triple support for a normal, healthy lifestyle. Red Yeast Rice contains beneficial unsaturated fatty acids including mono and polyunsaturated fatty acids, as well as proteins, amino acids and phytonutrients. CoQ-10 is intended to provide nutritive support for antioxidant activity, as well as other potential health benefits. The Omega 3 Fish Oil is a source of essential fatty acids EPA & DHA and is molecularly distilled. Size: 60ct Directions: Take 1 softgel daily, preferably with food. Serving Size: 1 N/A 60 Servings per container Ingredients: Amount per serving: - % Daily Value: + Trans Fat 0 g ~ Calories 10 ~ Coenzyme Q-10 30 mg ~ Calories from Fat 5 ~ Omega 3 Fish Oil Concentrate (Supplying 90 mg EPA and 60 mg DHA) 500 mg ~ Red Yeast Rice 600
Using two capsules of Red Yeast Rice a day, and eliminating butter and cheese from my diet, I was able to reduce my cholesterol by 12% (from 240 to 210). Note that Red Yeast Rice is identical to statin drugs like Lipitor (according to my doctor) except its possibly cheaper, and an herbal version. All the same issues with statin drugs still apply. I also use 2 daily capsules of 100mg NOW Co-Q10 along with the Red Yeast Rice, and I also take them with a meal containing healthy fats (eating sardines or avocado, or otherwise Ill take some fish oil capsules at the same time). You still have to watch your diet and limit saturated fats, but these help a little. ...
Covering up to February 2015 Phenylglycine-type amino acids occur in a wide variety of peptide natural products, including glycopeptide antibiotics and biologically active linear and cyclic peptides. Sequencing of biosynthesis gene clusters of chloroeremomycin, balhimycin and pristinamycin paved the wa
A recent report in BMC Biology on the discovery and analysis of biosynthetic genes for ribosomal peptide natural products confirms that these pathways are much more common and diverse than previously suspected, contributing substantially to the chemical arsenal employed by bacteria. See research article http://www.biomedcentral.com/1741-7007/8/70
Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.
The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well as the synthesis of structural analogues, bioactivity testing, biodistributional and biosynthetic studies. Here I also report on how well these compounds conform to Lipinskis rule of five for druglikeness and their predicted receptor binding and enzyme inhibitor activity. The composition of mycosporine-like amino acids, fatty acids and sterols has also been described in the egg masses of D. orbita. The combination of bioactive compounds produced by D. orbita is of interest for further studies in chemical ecology, as well as for future nutraceutical development. Biological insights into the life history of this species, as well as ongoing research on the gene expression, microbial symbionts
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: New Methodologies for Natural Products Chemistry (R01) RFA-RM-09-005. Roadmap
Peers Alley Media Invites Experts and Performers to Participate at Natural Product Chemistry Conferences. The event will welcome more than 300+ attendees from Europe, USA, Asia, Middle East, Canada,Japan and Australia.
The marine habitat represents an untapped source of bioactive compounds with promising therapeutic potential and clinical applications. As a result of intensive bioprospecting efforts in the search of bioactive secondary metabolites from the marine environment, during the last decade there has been a considerable increase in the number of marine natural products that have been successfully launched into the drug market (i.e., Yondelis®, Adcertis®, Halaven®). In addition, numerous potential marine-derived drug candidates are currently in advanced stages of clinical development. This has partly been driven by advances in sampling and analytical techniques as well as by novel high-throughput screening platform technologies. Nevertheless, the limited supply of promising bioactive metabolites from their natural sources remains one of the major bottlenecks in marine natural products drug discovery and development.As an alternative to the environmentally unsustainable wild harvesting, marine invertebrate
Meet industrialists, professors, researchers, drug manufactures, Pharmaceutical Companies, nano medicine scientists, Analytical Techniques industries from Europe, USA, Asia Pacific, Dubai at Drug discovery congress, Pharmaceutical Conferences, medicinal chemistry events, biomedical meetings 2018, 2019
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Plant natural product research can be facilitated through genome and transcriptome sequencing approaches that generate informative sequence and expression datasets that enable characterization of biochemical pathways of interest. As the overwhelming majority of plant-derived natural products are derived from Modern Methods in Plant Natural Products
Title:Thiazole: A Privileged Motif in Marine Natural Products. VOLUME: 16 ISSUE: 1. Author(s):Sunil Kumar* and Ranjana Aggarwal. Affiliation:Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Department of Chemistry, Kurukshetra University, Kurukshetra-136119. Keywords:Marine natural products, thiazoles, alkaloids, cytotoxic activity, privileged, secondary metabolite.. Abstract:Marine natural products have proven to be a rich source of drugs and drug leads. These natural products are secondary metabolites and show biological activity against bacteria, fungi and viruses. Natural products containing thiazole ring occur often in marine sources. They exhibit diverse and remarkable biological activities, including antitumor, antibacterial, anti-inflammatory and cytotoxic activities, to name a few. This review surveys the natural thiazole derivatives that have been isolated from marine microorganisms, with emphasis on biological implications in last three decades.. ...
Natures Way Red Yeast Rice Description: Red Yeast Rice is a unique natural product traditionally used in Asian culture. Disclaimer These statements have not be
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Red Yeast Rice list and information including what is Red Yeast Rice, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Red Yeast Rice list and information including what is Red Yeast Rice, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Real Natural Remedies Red Yeast Rice contains the same red yeast rice used to manage cholesterol in the research studies published in the Annals of Internal Medicine, the Archives of Internal Medicine and Mayo Clinic proceedings.
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This study will divide into two groups, single and multiple doses groups. In single dose group, the subjects will receive one, two and four red yeast rice capsules under fed state in period one to three, respectively. In multiple doses group, the subjects will receive red yeast rice capsules under fed state twice daily for 4.5 days. There is a minimum of a 5-days washout period before crossover of treatments.. In single dose treatment, the blood samples will be drawn prior to the dosing, and 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8 and 12 hours after the dosing.. In multiple doses treatment, the blood samples will be drawn prior to the 1st dosing, prior to the 7th dosing, prior to the 8th dosing, prior to the 9th dosing, and 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8 and 12 hours after the 9th dosing. ...
Red yeast rice vs niacin to lower cholesterol - I am 34 years old, 365 pds, I take niacin, red yeast rice and fish oil, for high cholesterol, hbp at what age should I consider a asprian regimen? Probably 50. Because of your age, your risk is still on the low side, so instead of starting aspirin, you should do your best to lose weight. I know I am not offering groundbreaking news to you, but often we discount the most important thing that we can do and look for the esoteric. A 34 year old non-diabetic, does not need to be on aspirin, you need to lose weight, no matter what length youd have to go to.
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Red yeast rice have favorable effects on lowering cholesterol. Solaray Red Yeast Rice 600 mg 120 caps is available on discount price at NutroVita.com ...
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China 100% Natural Red Yeast Rice Extract: 0.4%-3% Lovastatin; 0.4%, 1.5% Monacolin K., Find details about China Red Yeast Rice Extract, Monascus Purpureus from 100% Natural Red Yeast Rice Extract: 0.4%-3% Lovastatin; 0.4%, 1.5% Monacolin K. - Kingherbs Limited
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Red Yeast Rice helps reduce cholesterol. Taking Red Yeast Rice supplements can increase HDL (good) cholesterol and decrease in LDL (bad) cholesterol By lowering cholesterol levels Red Yeast Rice can also help prevent heart disease.
Red yeast rice (Monascus purpureus), a traditional Chinese medication, has been used for many years to effectively lower cholesterol.1,2 As a natural alternative to treat dyslipidemia, red yeast rice has the same chemical identity as lovastatin.1 Lovastatin along with the other HMG Co-A reductase inhibitors (statins) have been associated with statin-associated myopathy (SAM). This clinical syndrome can occur in 5% to 10% of statin users.2,3 Myopathy may be further categorized as myalgias (muscle pain), myositis (enzyme leak with increased creatine kinase levels), or rhabdomyolysis (creatine kinase elevations >10,000 u/L associated with acute renal failure). There is no consensus on how to treat dyslipidemias in patients who cannot tolerate statin therapy due to SAM. While, red yeast rice has been associated with the development of symptomatic myopathies only in case reports, it is perceived by some to be a real alternative to statin therapy.4 A recent clinical trial evaluated the effectiveness ...
On One Hand: Possibly an Effective Way to Fight Cholesterol.Red yeast rice is made by growing the yeast strain Monascus purpureus on rice. The end product is a reddish grain similar to white rice but with its own subtle flavor. Red yeast rice extract can be used for coloring and flavoring a variety of foods and is used in making certain rice wines and vinegars. At least one study conducted by the University of California Los Angeles Center for Human Nutrition showed positive health effects (including reducing cholesterol and high triglyceride levels) from the consumption of red yeast rice extract in a test group. Even so, the substance has...
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In 1994, U.S. Senators Harkins and Hatch got Congress to pass a law that prevented the FDA from regulating food, which in effect prevents the FDA from regulating any dietary supplements. In 2007 the FDA introduced new manufacturing standards for dietary supplements, but this study confirms that many manufacturers still are not checking the potency of their pills as they should. In 2010, the FDA issued further manufacturing guidelines designed to give consumers greater confidence that any dietary supplement they use has been manufactured to ensure its identity, purity, strength, and composition. However, the rate of adverse reactions to red yeast rice (muscle pain, gastrointestinal symptoms and muscle and liver damage) appears to be as common as it is for prescription statins (British Journal of Clinical Pharmacology, Jan. 19, 2017).. In 2014, the FDA sent a warning letter to a company whose red yeast rice product had 4mg of monacolin K/daily dose, a dose high enough to make it a drug that ...
Botanical names: Monascus purpureus How It Works In addition to rice starch, protein, fiber, sterols, and fatty acids, red yeast rice contains numerous active constituents, including monacolin K, dihydromonacolin, and monacolin I to VI. Researchers have determined that one of the ingredients in red yeast rice, called...
Natures Aid Red Yeast Rice provides 10mg of Monacolin K per daily serving. Monacolin K may help maintain normal blood cholesterol levels. Natures Aid Red Yeast Rice capsules have been manufactured using the finest Non-GM European approved rice.
Natures Aid Red Yeast Rice provides 10mg of Monacolin K per daily serving. Monacolin K may help maintain normal blood cholesterol levels. Natures Aid Red Yeast Rice capsules have been manufactured using the finest Non-GM European approved rice.
Founded: In 2004, as the PHCOG.NET - a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs. Pharmacognosy Journal (Phcog J.) is one of the six journals published by Phcog.Net, Each issue covers different topics in natural product drug discovery, and also publishes manuscripts that describe pharmacognostic investigations, evaluation reports, methods, techniques and applications of all forms of medicinal plant research ...
Founded: In 2004, as the PHCOG.NET - a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs. Pharmacognosy Journal (Phcog J.) is one of the six journals published by Phcog.Net, Each issue covers different topics in natural product drug discovery, and also publishes manuscripts that describe pharmacognostic investigations, evaluation reports, methods, techniques and applications of all forms of medicinal plant research ...
nbsp 0183 32 Red Yeast Monascus purpureus Red yeast rice or red rice yeast is the dried version of a red yeast Monascus purpureus that is grown on rice Originally from China known as Zhi Tai in Mandarin it has been used in Chinese Medicine as a blood vitalizer since the Tang dynasty 800 C E Many of the class of medicinals known as blood ...
Red Yeast Rice (RYR) is a natural product that has been used by Asian traditional herbalists for centuries and is produced by fermenting Red Yeast (Monascus purpureus) with rice. It is commonly used in cooking to enhance the color/flavor of foods. This NO
Red Yeast Rice (Monascus purpureus) has been used for centuries in the Chinese diet as a staple food and for its health benefits.*. Directions: As a dietary supplement, adults take two (2) capsules with any meal daily or as directed by a healthcare provider. Do not exceed four (4) capsules in a 24 hour period. Individual results may vary.. Keep out of reach of children. Do not use if product appears to be tampered with or seal is broken. Store at room temperature.. Warning: Do not use if you are pregnant, may become pregnant, or are breast feeding because using this product may cause birth defects. If you are taking any medications, or have any medical conditions (including liver disease), consult your doctor before use. Stop use and contact a physician if adverse reactions occur. Not intended for use by persons under the age of 18.. No added Sugar, Salt, Preservatives or Artificial Flavors. Gluten Free. This information may differ from the product you purchased. Please refer to the supplement ...
This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays in the field of natural products chemistry has led to the development of several novel pulse sequences. Hectochlorin was discovered during a phytochemical investigation of a cultured L. majuscula originally collected off the coast of the Caribbean Island, Jamaica. The absolute stereochemistry was determined by X-ray crystallography. Through a series of biological evaluations, this compound was found to stimulate actin polymerization. The jamaicamide class of compound was isolated from the same organism that yielded hectochlorin. The structures were elucidated utilizing a variety of NMR methods, including a newly developed pulse ...
Pharmacognosy Reviews (Phcog Rev.). [ISSN: Print -0973-7847, Online - 0976-2787] [http://www.phcogrev.com], a publication of Phcog.Net, Bangalore, INDIA. It is published Semi-annual, serves the need of different scientists and others involved in medicinal plant research and development. Each issue covers different reviews on related topics of natural product drug discovery, Biotechnology, Marine Pharmacognosy and Medicinal Plants. Review articles that are of broad readership interest to users in industry, academia, and government. Phcog Rev. is an important and most cited review journal for medicinal Plant researchers -and its an Open Access Publication.. Abstracting and Indexing Information. The journal is registered with the following abstracting partners ...
Pharmacognosy Reviews (Phcog Rev.). [ISSN: Print -0973-7847, Online - 0976-2787] [http://www.phcogrev.com], a publication of Phcog.Net, Bangalore, INDIA. It is published Semi-annual, serves the need of different scientists and others involved in medicinal plant research and development. Each issue covers different reviews on related topics of natural product drug discovery, Biotechnology, Marine Pharmacognosy and Medicinal Plants. Review articles that are of broad readership interest to users in industry, academia, and government. Phcog Rev. is an important and most cited review journal for medicinal Plant researchers -and its an Open Access Publication.. Abstracting and Indexing Information. The journal is registered with the following abstracting partners ...
Pharmacognosy Reviews (Phcog Rev.). [ISSN: Print -0973-7847, Online - 0976-2787] [http://www.phcogrev.com], a publication of Phcog.Net, Bangalore, INDIA. It is published Semi-annual, serves the need of different scientists and others involved in medicinal plant research and development. Each issue covers different reviews on related topics of natural product drug discovery, Biotechnology, Marine Pharmacognosy and Medicinal Plants. Review articles that are of broad readership interest to users in industry, academia, and government. Phcog Rev. is an important and most cited review journal for medicinal Plant researchers -and its an Open Access Publication.. Abstracting and Indexing Information. The journal is registered with the following abstracting partners ...
Matthies S, Stallforth P, Seeberger PH (2015) Total Synthesis of Legionaminic Acid as Basis for Serological Studies J Am Chem Soc 137, 2848-2851. ...
Phcog.Net - A Platform for Natural Product Researchers was created to combat these problems. It makes innovative use of the best tools for information dissemination to overcome the hurdles to Natural Product Research. Phcog.Net is a private organization dedicated to Natural Products Research in order to develop promising drugs.. Learn more, visit www.phcog.net. BEMS Reports - [ISSN: 2454 - 6895] An official publication of Phcog.Net and the journals and its contents owned by Phcog.Net are licensed under a Creative Commons Attribution-Non Commercial-No Derivs 4.0 License. Permissions beyond the scope of this license may be available with [email protected] Copyright 2015-16 Phcog.Net , Publishing partner: EManuscript Services. ...
Phcog.Net - A Platform for Natural Product Researchers was created to combat these problems. It makes innovative use of the best tools for information dissemination to overcome the hurdles to Natural Product Research. Phcog.Net is a private organization dedicated to Natural Products Research in order to develop promising drugs.. Learn more, visit www.phcog.net. BEMS Reports - [ISSN: 2454 - 6895] An official publication of Phcog.Net and the journals and its contents owned by Phcog.Net are licensed under a Creative Commons Attribution-Non Commercial-No Derivs 4.0 License. Permissions beyond the scope of this license may be available with [email protected] Copyright 2015-16 Phcog.Net , Publishing partner: EManuscript Services. ...
Four new iridoid glycosides named cornusphenosides A-D (1-4) were isolated from an ethanol extract of the fruits of Cornus officinalis (shan zhu yu). The structures of these compounds were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, and 1D and 2D NMR) and chemical evidence. The neuroprotective effects of compounds 1-4 were also assessed in vitro ...
BioNatH is a central research group within Pharmacognosy.. The research deals with isolation and structurally elucidation of biologically active components from plants used as medicines and food. Testing of relevant bioactivities is also part of the research.. ...
"Shenzhen Kangtai Biological Products Co Ltd". Bloomberg. Retrieved 1 August 2021. "Kangtai Biological's COVID-19 vaccine gets ... Coordinates: 22°32′48″N 113°56′37″E / 22.5467°N 113.9437°E / 22.5467; 113.9437 Shenzhen Kangtai Biological Products (Chinese ... manufactures and markets vaccines and other vaccine products. Kangtai develops the Minhai COVID-19 vaccine and has the ...
The Wuhan Institute of Biological Products (WIBP Chinese: 武汉生物制品研究所) or Wuhan Institute of Biology for short is a subsidiary of ... Philippidis, Alex (May 18, 2020). "Sinopharm Group (Wuhan Institute of Biological Products) and Chinese Academy of Sciences ( ... and operates one of the main production facilities for biological products in China, with over 1,000 employees. The commercial ... which is primarily focused on the production distribution of blood products including human albumin, human immune globulin and ...
Full Prescribing Information" (PDF). Janssen Products, Dec 2012. Retrieved 24 February 2020. Nikolas C Papanikolaou; Eleftheria ... Polonium in the body has a biological half-life of about 30 to 50 days. Caesium in the body has a biological half-life of about ... Lead in bone has a biological half-life of about ten years. Cadmium in bone has a biological half-life of about 30 years. ... Plutonium in bone has a biological half-life of about 100 years. Plutonium in the liver has a biological half-life of about 40 ...
Biosimilars are defined by the FDA as, "a biological product that is highly similar to and has no clinically meaningful ... which often does not include traditional biological substances like vaccines. Today, biological therapy most commonly refers to ... Biological therapy has found a niche in the management of cancer, autoimmune diseases, and diseases of unknown cause that ... The advancements in biological therapy greatly changed how IBD is treated. Patients with Crohn's disease and ulcerative colitis ...
Drug discovery Environmental impact of pharmaceuticals and personal care products Raffa RB, Porreca F (1989). "Thermodynamic ... Databases containing biological targets information: Therapeutic Targets Database (TTD) DrugBank Binding DB These biological ... A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is ... Biological targets are most commonly proteins such as enzymes, ion channels, and receptors. The external stimulus (i.e., the ...
Bandaranayake WM (April 2006). "The nature and role of pigments of marine invertebrates". Natural Product Reports. 23 (2): 223- ... Biological pigments include plant pigments and flower pigments. Many biological structures, such as skin, eyes, feathers, fur ... However, some biological pigments in animals, such as heme groups that help to carry oxygen in the blood, are colored as a ... Biological pigments, also known simply as pigments or biochromes, are substances produced by living organisms that have a color ...
... and conversion of livestock waste to energy and products. They awarded this grant to 24 renewable energy projects at the ... The College of Biological Sciences at the University of Minnesota is one of the few colleges nationwide devoted to biological ... "Biochemistry , College of Biological Sciences". cbs.umn.edu. Retrieved 2022-07-29. "Biology , College of Biological Sciences". ... "Microbiology , College of Biological Sciences". cbs.umn.edu. Retrieved 2022-07-29. "Neuroscience , College of Biological ...
In addition, gene products rarely act alone. Instead, they perform their function by interacting together in pathways and ... but there are five main methods used to investigate the biological basis of personality. The biological data from these methods ... The biological basis of personality is the collection of brain systems and mechanisms that underlie human personality. Human ... From a biological perspective, these traits can be traced back to brain structures and neural mechanisms. However, this ...
Frozen or dried berries may be preferable for some baked berry products. Fresh berries are also often incorporated into baked ... Thiem B (2003). "Rubus chamaemorus L. - a boreal plant rich in biologically active metabolites: a review" (PDF). Biological ... Consequently, it is not permitted to claim that foods containing polyphenols have antioxidant health value on product labels in ... Yanyun Zhao (6 June 2007). Berry Fruit: Value-Added Products for Health Promotion. CRC Press. ISBN 978-1-4200-0614-8. Pritts, ...
Bee products, Dietary supplements, Beekeeping, Animal glandular products). ... Biological Reviews. 89 (2): 255-269. doi:10.1111/brv.12052. PMID 23855350. S2CID 29361726. Albert, Stefan; Bhattacharya, ... "Value-added products from beekeeping. Chapter 6". Buttstedt, Anja; Moritz, Robin F. A.; Erler, Silvio (May 2014). "Origin and ... "Federal Government Seizes Dozens of Misbranded Drug Products: FDA warned company about making medical claims for bee-derived ...
"Approved Products - ACAM2000". www.fda.gov. Retrieved 2018-09-08. "Biological Threats". Emergent BioSolutions. Retrieved 2018- ... Smallpox is considered a biological threat. Biological agents are toxins or organisms that can cause illness or death in humans ... Exposure can come from an intentional biological terrorist attack, accidental release of the agent, or a natural accident. ... enhances the emergency preparedness of the United States against the use of smallpox as a dangerous biological weapon." The ...
doi:10.1016/S0034-4257(99)00023-1. Battersby AR (December 2000). "Tetrapyrroles: the pigments of life". Natural Product Reports ... Biological Bulletin. 136 (1): 54-62. doi:10.2307/1539668. JSTOR 1539668. Gilpin L (21 March 2001). "Methods for analysis of ... Willows RD (June 2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports. 20 (3): 327-41. doi: ... Journal of Biological Education. 56 (5): 1-8. doi:10.1080/00219266.2020.1858930. May P. "Chlorophyll". University of Bristol. " ...
ISBN 1-4757-1856-X. John W. Blunt, Murray H. G. Munro (2013). Dictionary of Marine Natural Products. CRC Press. ISBN 0-8493- ... Biological Control. 44: 24. doi:10.1016/j.biocontrol.2007.10.005. Stewart, M; Capon, R. J.; Lacey, E; Tennant, S; Gill, J. H. ( ... Journal of Natural Products. 68 (4): 581-4. doi:10.1021/np049614y. PMID 15844954. Capon, R. J.; Stewart, M; Ratnayake, R; Lacey ... Journal of Natural Products. 70 (11): 1746-52. doi:10.1021/np0702483. PMID 17958395. Stewart, M; Capon, R. J.; Lacey, E; ...
Public understanding and responsible uses of biological engineering products. Through publications, meetings, distribution of ... The Institute of Biological Engineering or IBE is a non-profit professional organization which encourages inquiry and interest ... The IBE was established in 1995 to encourage inquiry and interest in biological engineering in the broadest and most liberal ... IBE promotes the view that biological engineering is a science-based, application-independent discipline that is aligned with ...
No biological tests confirm major depression. In general, investigations are not repeated for a subsequent episode unless there ... Duff G (31 May 2006). "Updated prescribing advice for venlafaxine (Efexor/Efexor XL)". Medicines and Healthcare products ... Adolf Meyer put forward a mixed social and biological framework emphasizing reactions in the context of an individual's life, ... The biopsychosocial model proposes that biological, psychological, and social factors all play a role in causing depression. ...
The products are primarily marketed as biological and biochemical fertilizer catalysts that increase nutrient availability, ... In July 2012, Agricen entered a strategic partnership with Loveland Products, Inc., a provider of crop input products and part ... Products are also available through Nutrien Ag Solutions locations in Canada, Australia and several countries in South America ... Agricen's products, which are manufactured in Denton, Texas and Victoria, Australia, are derived from natural microorganisms ...
If the product being tested causes the endotoxin recovery to be less than expected, the product is inhibitory to the LAL test. ... Series B, Physical and Biological Sciences. 83 (4): 110-9. Bibcode:2007PJAB...83..110I. doi:10.2183/pjab.83.110. PMC 3756735. ... In the United States, the FDA has published a guideline for validation of the LAL test as an endotoxin test for such products. ... Proper endotoxin recovery must be proven before LAL can be used to release product. The LAL test is a major source of animal ...
The compound is the first natural product that has in vivo potential against the T. brucei. Cynaropicrin is a compound with ... Its γ-butyrolactone ring is involved in most of its biological functions. The unsaturated carbonyl group on the lactone ring ... On hydrogenation products of cynaropicrin, the bitter principle of artichoke (Cynara scolymus L.)". Collection of Czechoslovak ... Mander, Lewis N. Liu, Hung-wen, 1952- (2012). Comprehensive natural products II : chemistry and biology. Elsevier. ISBN 978-1- ...
The company provides product development and cell culture services to the pharmaceutical and biological industries, including ... "Biological Industries named exclusive distributor of ATCC products in Israel". (Articles needing additional references from ... Biological Industries (BI) was founded in 1982 in the northern Kibbutz Beit Haemek, Israel. The company has expanded in the ... Biological Industries is an Israel multinational, chemicals and biotechnology company, headquartered in Israel, with R&D and ...
"Veterinary Biological Products" (PDF). USDA. April 1, 2020. Legendre, Al (2017). "Polyprenyl Immunostimulant in Feline ...
Dewick, Paul M (2009). Medicinal Natural Products: a biosynthetic approach (3rd ed.). Chichester U.K.: Wiley. p. 312. ISBN ... Journal of Biological Chemistry. 264 (20): 11744-11749. doi:10.1016/S0021-9258(18)80128-4. PMID 2745415. ...
"Biological Abstracts - Journal List". Intellectual Property & Science. Thomson Reuters. Archived from the original on 2016-01- ... "Journal of Natural Products". Library of Congress Catalog. Library of Congress. Retrieved 2016-01-19. Beall, Jeffrey. "Another ... "Journal of Natural Products". 2021 Journal Citation Reports. Web of Science (Science ed.). Clarivate. 2022. Official website ( ... The Journal of Natural Products is a monthly peer-reviewed scientific journal covering all aspects of research on the chemistry ...
... as well as spills of refined petroleum products (such as gasoline, diesel) and their by-products, heavier fuels used by large ... They are any biological species or group of species whose function, population, or status can reveal what degree of ecosystem ... Various chemical compounds found in personal hygiene and cosmetic products. Disinfection by-products found in chemically ... Biological testing involves the use of plant, animal or microbial indicators to monitor the health of an aquatic ecosystem. ...
Journal of Biological Chemistry. 290 (23): 14729-14739. doi:10.1074/jbc.M114.633065. ISSN 0021-9258. PMC 4505538. PMID 25911105 ... A Tax Gene Product (Tax) is a nuclear protein that has a molecular weight of about 37,000 to 40,000 daltons. Tax is produced by ... The Journal of Biological Chemistry. 279 (31): 31991-4. doi:10.1074/jbc.r400009200. PMID 15090550. Charoenthongtrakul, Soratree ...
Products commonly used for household disinfection such as Clorox® and Lysol® disinfecting wipes do not work against these ... 1994). Rabbit Haemorrhagic Disease: Issues in Assessment for biological control. Canberra: Bureau of Resource Sciences. ISBN ... "EPA's registered antimicrobial products effective against Norovirus". US Environmental Protection Agency. 28 September 2015. ... "CVMP assessment report for ERAVAC" (PDF). Committee for Medicinal Products for Veterinary Use, European Medicines Agency. ...
Masters, Bettie Sue Siler (2009-07-24). "A Professional and Personal Odyssey". Journal of Biological Chemistry. 284 (30): 19765 ... Mosbach, K. (1969). "Biosynthesis of Lichen Substances, Products of a Symbiotic Association". Angewandte Chemie International ...
Other biological functions for which CSGAGs are known to play critical functions in include inhibition of axonal growth and ... 2002). "Heparin and heparan sulfate: structure and function". Natural Product Reports. 19 (3): 312-31. doi:10.1039/B100916H. ... It is believed that through differences in enzyme activity and expression, the wide spectrum of biological functions mediated ... Heparan sulfate (HS) has numerous biological activities and functions, including cell adhesion, regulation of cell growth and ...
Journal of Biological Chemistry. 274 (28): 19919-19924. doi:10.1074/jbc.274.28.19919. Liu, Ting; Zhang, Lingyun; Joo, Donghyun ... Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They are ... Yan, Hai-dong; Li, Xue-zhu; Xie, Jun-mei; Li, Man (May 2007). "Effects of advanced glycation end products on renal fibrosis and ... Finally, AGEs can bind to RAGE (receptor for advanced glycation end products) and cause oxidative stress as well as activation ...
... household product ingredient, industrial additive, personal care product/cosmetic ingredient, pesticide ingredient, plastic/ ... Burton G. W., Ingold K. U. (1981). "Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related ... Household Products Database. [1] Archived 2015-09-05 at the Wayback Machine.US EPA. InertFinder. [2]. US National Library of ... Some food companies have voluntarily eliminated BHT from their products or have announced that they were going to phase it out ...
Natural Product Letters. 6 (3): 181-185. doi:10.1080/10575639508043156. Kim, J.-C.; Choi, G. J.; Park, J.-H.; Kim, H. T.; Cho, ... Agricultural and Biological Chemistry. 55 (8): 2037-2042. doi:10.1080/00021369.1991.10870928. Harwooda, John S.; Cutler, Horace ... Journal of Asian Natural Products Research. 11 (11): 962-6. doi:10.1080/10286020903339614. PMID 20183261. Hudson, H. J. ( ...
In the presence of OMP, the product of the OPRTase, the dimer changes to a faster-sedimenting form S20,w 5.6. These separate ... In the biological reaction, a proton transference to the pyrophosphate (PPi) molecule could minimize negative charge ... UMPS is subject to complex regulation by OMP, the product of its OPRTase and the substrate for the ODCase. OMP is an allosteric ... Selenilation products have also been used. Abdo et al. (2010) performed reactions on 2-ethoxiethanselenic acid using electron- ...
Crameri R, Jaussi R, Menz G, Blaser K (November 1994). "Display of expression products of cDNA libraries on phage surfaces. A ... US patent 5866363, Pieczenik G, "Method and means for sorting and identifying biological information", published 1999-02-02 ... versatile screening system for selective isolation of genes by specific gene-product/ligand interaction". Eur. J. Biochem. 226 ...
Furthermore, the product of PTGS2 (COX-2), PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can ... The two 15-HETE stereoisomers have intrinsic biological activities but, perhaps more importantly, can be further metabolized to ... Furthermore, aspirin-treated COX-2 metabolizes arachidonic acid almost exclusively to 15(R)-HETE which product can be further ... The absence of endoperoxide-containing products derived from 10,10-difluoroarachidonic acid has been thought to indicate the ...
... medical product and food industries, health care providers, and at large representatives with relevant expertise and experience ... Reagan-Udall Foundation convened a Systems Toxicology Project with the ultimate goal of directly identifying common biological ... regulatory science and technology in order to enhance the safety and effectiveness of FDA regulated products. Although it was ... and methodologies for post-market product surveillance under a program called Innovation in Medical Evidence Development and ...
One non-biological area where DIC is used is in the analysis of planar silicon semiconductor processing. The thin (typically ... The interference of the two parts at recombination is sensitive to their optical path difference (i.e. the product of ... DIC is used for imaging live and unstained biological samples, such as a smear from a tissue culture or individual water borne ...
According to a 2022 report from World Animal Protection and the Center for Biological Diversity around 235 million pounds of ... The report argues consumers should reduce their consumption of animal products and to transition towards plant-based diets in ... A substantial reduction of impacts would only be possible with a substantial worldwide diet change, away from animal products. ... Other than climate change, environmental concerns about the production of animal products may also relate to biodiversity loss ...
231-235, in Walter Davis, Stephan Tanneberger "The Control of tumour growth and its biological bases" Springer, 1983, ISBN 0- ... Schaunardimycin". Journal of Natural Products. 47 (4): 698-701. doi:10.1021/np50034a022. PMID 6491682. Dodion, P.; Rozencweig, ... Journal of Natural Products. 69 (11): 1626-8. doi:10.1021/np0602721. PMID 17125235. Doyle, Terrence W.; Nettleton, Donald E.; ... Journal of Natural Products. 43 (2): 242-58. doi:10.1021/np50008a003. PMID 7381507. Richard Alan Strehlow Standardization of ...
González, Miguel A. (2015). "Aromatic abietane diterpenoids: their biological activity and synthesis". Natural Product Reports ... are of interest to the pharmacology and natural products communities for their potential biological activities. In the rock ... The ratio of oxidation products of abietanes including dehydroabietic acid and de-7-oxo-dehydroabietic acid and 15-hydroxyl-7- ... biological activities, and therapeutic uses". Planta Medica. 59 (6): 485-490. doi:10.1055/s-2006-959744. PMID 8302943. Otto, A ...
It read, "Doubt is our product since it is the best means of competing with the 'body of fact' that exists in the mind of the ... A cornerstone of modern scientific biological theory is that all forms of life on Earth are related by common descent with ... "Original "Doubt is our product..." memo". University of California, San Francisco. 21 August 1969. Retrieved 3 October 2012. ...
When Jia's biological mother refused to accept her, Jennifer adopted her. Unable to deal with the guilt, Jennifer's husband ... "well-crafted product". David Parkinson of Radio Times wrote that the film "retains a distinctive Bollywood flavour", despite ...
Hemophilia and Obesity Products, Other Small Molecule and Biological Therapeutics, Vaccines Strategic Investments: ARNO ... Vitamin D and Phosphate Management Products, Growth Hormone, ...
The Journal of Biological Chemistry. 245 (2): 390-401. doi:10.1016/S0021-9258(18)63404-0. PMID 4904482.[permanent dead link] ... whereas its two products are tetrahydropteroyltri-L-glutamate and L-methionine. This enzyme participates in methionine ...
Like all biological systems, the mind is optimised to promote survival and reproduction in the evolutionary environment. On ... An alternative explanation is that religious psychology is a by-product of many parts of the mind that originally evolved for ... Our brains are, after all, biological objects, and the best naturalistic account of their development in nature is Darwin's ... who first argued that religious cognition represents a by-product of various evolutionary adaptations, including folk ...
The primary decay products before 142Nd are element Pr (praseodymium) isotopes and the primary products after are element Pm ( ... Neodymium is otherwise not known to have a biological role in any other organisms. Neodymium metal dust is combustible and ... The product is then dried and leached with water, leaving the early lanthanide ions, including lanthanum, in solution. ... Von Welsbach confirmed the separation by spectroscopic analysis, but the products were of relatively low purity. Didymium was ...
This is done by deformation (to control the depth to which the bullet penetrates) which, as a by-product, causes more damage ... More rarely, others are used to release chemical or biological agents, either on impact or when over the target area; designing ...
These findings suggest that the CMTM5 gene may act as a tumor suppressor gene, i.e. a normal gene whose product(s) inhibit the ... Wu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical ... to determine if expression of the CMTM5 gene's or its products can be used as makers for patient susceptibilities to coronary ... International Journal of Biological Sciences. 15 (12): 2576-2583. doi:10.7150/ijbs.33733. PMC 6854381. PMID 31754330. Cai B, ...
... drew attention to the heritage of lay people's sustainable products and their lifestyle. Likewise, in 2001, the first Textile ... and Bomdeling Wildlife Sanctuary established in 1993 UN Framework Convention on Climate Change and Convention on Biological ... advocated the use of a Gross National Happiness index to measure the well-being of citizens rather than Gross domestic product ...
... which define the paths from precursors to final products by identifying radioactively labelled intermediates and products. The ... Series B, Biological Sciences. 293 (1063): 5-22. Bibcode:1981RSPTB.293....5B. doi:10.1098/rstb.1981.0056. PMID 6115423. Pilkis ... Although some more ATP is generated in the citric acid cycle, the most important product is NADH, which is made from NAD+ as ... Capaldi RA, Aggeler R (March 2002). "Mechanism of the F(1)F(0)-type ATP synthase, a biological rotary motor". Trends in ...
Chemical transfer pathway between Earth's biological and non-biological parts Consumer-resource interactions Ecological network ... In food web terminology, complexity is a product of the number of species and connectance. Connectance is "the fraction of all ... Linkages connect to nodes in a food web, which are aggregates of biological taxa called trophic species. Trophic species are ... as well as products secreted, excreted or exuded from organisms (e.g. extra-cellular polymers, nectar, root exudates and ...
The impact of product production depends on how the product is created. Substrate inhibition will affect products produced by ... "Overcoming substrate inhibition during biological treatment of monoaromatics: recent advances in bioprocess design". Applied ... However, if a product is being produced by cells, then substrate inhibition will narrow product formation by limiting the ... is the product concentration. The product formation and cell growth are both directly linked to the amount of substrate ...
Mulder LC, Muesing MA (Sep 2000). "Degradation of HIV-1 integrase by the N-end rule pathway". The Journal of Biological ... Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... The CP and RPs pertain distinct structural characteristics and biological functions. In brief, 20S sub complex presents three ... To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be ...
As a result, structural proteins, resulting from polypeptide products of gag and gag-pol genes, that are necessary for the HIV ... Brazilian Journal of Medical and Biological Research. 39 (8): 1065-70. doi:10.1590/s0100-879x2006000800009. PMID 16906281. ...
The privately funded Computational Sciences Facility and Biological Sciences Facility house about 310 staff who support PNNL's ... Within BSEL, researchers are developing technology for converting agricultural byproducts into chemicals for products like ... APEL provides engineering- and manufacturing-scale space and chemical, biological, and electronic laboratories and equipment ... for developing, validating, and commercializing new products. Three research facilities were constructed on PNNL's Richland, ...
"β-Catenin". Sino Biological Inc.: Biological Solution Specialist. Reynolds AB (June 2011). "Epithelial organization: new ... These gene products are important in determining cell fates during normal development and in maintaining homeostasis, or they ... a tumor suppressor gene product), CSNK1A1, and GSK3B. Following phosphorylation of the N-terminal Ser and Thr residues of β- ...
It stars Jessica De Gouw as the co-founder of Otherlife, a company that developed a form of biological virtual reality. When ... A week before the product launch, she is testing its code on herself under the supervision of engineer Byron Finbar. Unknown to ... Sam pitches OtherLife to investors, telling them they can market the product as a near-instantaneous experience that can last ... Using nanotechnology, Ren invents a biological form of virtual reality called OtherLife that can create realistic memories. ...
Ray's research has focused on understanding the biological role of methylglyoxal, a side-product of several metabolic pathways ... 1975: Indian National Science Academy (INSA) Young Scientist Medal in Biological Science 1989: Shanti Swarup Bhatnagar Prize ... Biological Sciences'. Ray graduated from the prestigious Science college campus of Calcutta University with degrees in M.Sc. in ... Recipients of the Shanti Swarup Bhatnagar Award in Biological Science, Women scientists from West Bengal). ...
Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc ... The Journal of Biological Chemistry. 255 (23): 11247-52. PMID 6449507. Beta-1,3-galactosyl-O-glycosyl-glycoprotein+beta-1,6-N- ... Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis". Carbohydrate ... leads to GalNAc) beta 6-N-acetylglucosaminyltransferase". The Journal of Biological Chemistry. 255 (23): 11253-61. PMID 6449508 ...
EuroChem invested in biological crop nutrition company Agrinos for research and development into a new generation of products. ... EuroChem products are sold in more than 100 countries. EuroChem Group has raised funds on the international capital markets. In ... EuroChem produces commodity and specialty fertilizers including inhibitor products that allow slow release of nutrients into ... including advanced slow-release products aimed at reducing the environmental footprint of the agricultural sector. EuroChem ...
Kimura (2013). "Natural products and biological activity of the pharmacologically active cauliflower mushroom Sparassis crispa ... Experiments suggest that S. crispa contains chemicals that may stimulate the immune system and has many biological properties ... "Biological peculiarities of a rare mushroom Sparassis nemecii (Sparassidaceae, Polyporales) on plant substrates in pure culture ...
Series B, Containing Papers of a Biological Character Volume 95, Issue 666, pp. 157-163 Publication Date: 8/1923 Ooi (2004) " ... salted fish and other products. The Dusun has a special term to describe this type of trading activity, i.e. mongimbadi. This ...
Includes Human Tissue and Cellular and Tissue-Based Product (HCT/P) Deviation Reporting. ... The product codes are used to identify the product(s) affected.. Biological product deviations reports required by 21 CFR ... Biological Product Deviation Reporting and HCT/P Deviation Reporting - Deviation Codes. *Biological Product Deviation Reporting ... Biological product deviations reports required by 21 CFR 600.14, involving a therapeutic product regulated by the Center for ...
Quality of biological products moving in international commerce: draft resolution proposed by the delegations of Argentina, ...
Currently Licensed Veterinary Biological Products (includes imported under permit). Current Veterinary Biologics Product ... The lack of data for those products does not mean those products are any less efficacious or less safe than those products for ... studies used to license a particular USDA-regulated veterinary biological product. Product summaries are published for vaccines ... All products must provide a significant, clinically meaningful effect.. *Efficacy studies are conducted with a product batch ...
Biosafety guidelines for personnel engaged in the production of vaccines and biological products for medical use  ... Biological substances, international standards and reference reagents : 1990  World Health Organization (‎World Health ... WHO Expert Committee on Biological Standardization; World Health Organization (‎Organisation mondiale de la Santé, 1955)‎ ... WHO Expert Committee on Biological Standardization; World Health Organization (‎Organisation mondiale de la Santé, 1963)‎ ...
Workshop Products. Workshop Products. Meetings & Workshops. Primary meetings and workshops held to bring about community input ... The Distributed Biological Observatory: A Change Detection Array to track Ecosystem Responses to Physical Drivers in the ... 2014 Distributed Biological Observatory (DBO). October 29-31, 2014. * 2nd Data Workshop Final Report ...
means a biological product as that term is defined in 42 USC 262. ... Biological drug product. means a biological product as that ... follow-on biological product, follow-on protein product, similar biological medicinal product, or biosimilar product) that has ... Examples of Biological drug product in a sentence. *. Biological drug product - A finished dosage form that contains an active ... Reference biological product means the single biological product licensed pursuant to 42 U.S.C. ...
... regulatory and biological aspects. Download Prime PubMed App to iPhone, iPad, or Android ... UVA filters in sun-protection products: regulatory and biological aspects.. Photochem Photobiol Sci. 2012 Jan; 11(1):81-9.PP ... Fourtanier A, Moyal D, Seite S. UVA filters in sun-protection products: regulatory and biological aspects. Photochem Photobiol ... Fourtanier A, Moyal D, Seite S. UVA Filters in Sun-protection Products: Regulatory and Biological Aspects. Photochem Photobiol ...
... small pilot research plants to large commercial multi-dryer industrial Laboratory Freeze Dryer for Drying Biological Product ... Laboratory Freeze Dryer for Drying Biological Product manufactures a range of Laboratory Freeze Dryer for Drying Biological ... Product from pilot models to large capacity industrial Industrial Freeze Dryer Machine. From 5.5kg to 1500kg ice condenser ... Home,Products,Industrial Freeze Dryer Machine,Laboratory Freeze Dryer for Drying Biological Product ...
Portland, magnesium phosphate binders sprout biological concrete. January 11, 2013. Concrete News ... In order to obtain the biological concrete, pH factor aside, other parameters influencing the materials bioreceptivity have ... From an environmental perspective, the new concrete absorbs and reduces atmospheric carbon dioxide due to its biological ... UPC officials cite the potential for commercialization of the product through a Catalan architectural precast producer, Escofet ...
... lay out their preferred organic and biological products that they use and explain why. ... This article is tagged with biological products, biologicals, Clean Air Lawn Care, McPherson Turf Care, organic products, ... What organic and biological products do you use and why?. Katie Felts-Martin ... Many lawn care companies say theyve switched to biological and organic products just within the past few years. (Photo: ...
Fly Eliminators® - Biological Fly Control * How To Build Your Fly Control Program ...
New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product Thomas J. Divers, Bud C ... website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products ...
Identification and quantification of degradation products from ceramics ... Biological evaluation of medical devices - Part 14: Identification and quantification of degradation products from ceramics. ... Sign up to our newsletter for the latest news, views and product information. ...
Phytochemical studies on natural products and their biological activities against Trypanosoma Author: Alenzi, Naif ISNI: 0000 ... Different biological effects have been allocated to propolis extracts by earlier studies and their phytoconstituents have been ... Propolis is also receiving ample attention in the context of initiatives to discover novel drugs, thanks to its biological and ... One plant considered to have biological effects is Holy Basil (Ocimum sanctum L.), with pre-clinical screening uncovering many ...
The applicants of similar biological medicinal products, who have applied for scientific advice from the CHMP, expressed the ... The applicants of similar biological medicinal products, who have applied for scientific advice from the CHMP, expressed the ... to be addressed within the development programs of similar biological medicinal products. ... Eudralex Volume 3 GUIDELINE ON SIMILAR BIOLOGICAL MEDICINAL PRODUCTS. Internet:. https://www.gmp-compliance.org/files/guidemgr/ ...
New Government Action Aims to Increase Competition among Biological Products: FDA and FTC Step Up Industry Pressure By Joanne S ... market for biological products…[which] might include anticompetitive reverse payment agreements, abusive regulatory filings, or ... "Promotional Labeling and Advertising Considerations for Prescription Biological Reference and Biosimilar Products: Questions ... related implications when bringing a new FDA-regulated product to market and how to ensure continued compliance after a product ...
610.60(a) (21 CFR 610.60(a)) specifies which items must appear on the label affixed to each container of a biological product ... 610.60(a) (21 CFR 610.60(a)) specifies which items must appear on the label affixed to each container of a biological product ... Human drugs, biological products, and animal drugs; foreign and domestic establishment registration and listing requirements, * ... the products potential adverse reactions which have been associated with the products use. 21 C.F.R. §§ 610.60-610.65. The ...
null New publication on an EDQM Biological Standardisation Programme study for standardisation of allergen products ... New publication on an EDQM Biological Standardisation Programme study for standardisation of allergen products ...
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  • Potency assays based on GM cell lines are currently used for the quality control of biological products including cytokines , hormones , therapeutic antibodies , vaccines and gene therapy products. (bvsalud.org)
  • The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. (fda.gov)
  • According to the report published by Zion Market Research, global demand for biological safety testing market was valued at approximately USD 2,200 Million in 2019, and is expected to generate revenue of around USD 4,658 Million by end of 2026, growing at a CAGR of around 12.5% between 2020 and 2026. (zionmarketresearch.com)
  • Product licensing efficacy and safety data will be available on the website within 30 days of licensure for veterinary biologics licensed after December 15, 2016. (usda.gov)
  • The five-page Joint Statement provides a brief history of biosimilar products in the U.S. since Congress created the abbreviated pathway for follow-on biologics in 2010 and notes that although FDA has approved 26 biosimilars so far, many of them have not been launched commercially due to "business and intellectual property concerns. (mintz.com)
  • The applicants of similar biological medicinal products, who have applied for scientific advice from the CHMP, expressed the need for specific guidance. (gmp-compliance.org)
  • The advances as well as the limitations of methods and techniques available today for the full characterization of such medicinal products have already prompted the CHMP to initiate a number of specific guidelines relevant to quality, non-clinical and clinical issues, to be addressed within the development programs of similar biological medicinal products. (gmp-compliance.org)
  • The Act amends the Public Health Service Act in order to extend, fund, and improve several programs designed to prepare the United States and health professionals in the event of a pandemic, epidemic, or biological, chemical, radiological, or nuclear accident or attack. (govtrack.us)
  • and (4) strategic initiatives to advance countermeasures to diagnose, mitigate, prevent, or treat harm from any biological agent or toxin or any chemical, radiological, or nuclear agent or agents, whether naturally occurring, unintentional, or deliberate. (govtrack.us)
  • The ASP IFU and User Guide library allows users to search by language, country and product to locate the appropriate instructions for use of ASP Products. (asp.com)
  • This study focuses on assessing the effectiveness of a rhamnolipid biosurfactant (JBR 425(TM)) and two other commercial biological products on biodegradation of weathered light crude oil, heavy crude oil, and diesel fuel spilled on saline water following the USEPA's biological effectiveness test method. (concordia.ca)
  • While mechanical and chemical processes have proven to have limited effectiveness, in many cases biological techniques are promising alternatives because of the lower costs, environmental friendliness associated with them. (concordia.ca)
  • The National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention announced the availability of a draft chapter to be published in the NIOSH Manual of Analytical Methods (NMAM) entitled "Application of Biological Monitoring Methods for Chemical Exposures in Occupational Health" for public comment. (cdc.gov)
  • NIOSH researchers have written an updated chapter covering the application and validation of biological monitoring methods for chemical exposures in occupational health and safety to be included in NMAM. (cdc.gov)
  • Increasing awareness regarding the adverse effect of chemical seed treatment among the health-conscious population is boosting the utilization of biological seed treatment solutions. (reportsanddata.com)
  • Paper presents diverse modes of governance of chemical and biological risks in agri-food sector, assesses their efficiency, complementarities, and challenges, and suggests recommendations for public policies improvement. (repec.org)
  • Management of chemical and biological risks in agri-food chain ," MPRA Paper 30905, University Library of Munich, Germany. (repec.org)
  • The receptor for advanced glycation end products is required for �-catenin stabilization in a chemical-induced asthma model. (rndsystems.com)
  • Some sources of exposure remain hidden due to insufficient chemical identification in many household or industrial products. (medscape.com)
  • December 16, 2021 - Univar Solutions Inc. (NYSE: UNVR), a global chemical and ingredient distributor and provider of value-added services, today announced a new agreement with Novozymes, the world leader in biological solutions, expanding the partnership between the two companies into the homecare and industrial cleaning market for Brazil, Mexico, Paraguay, Uruguay and Bolivia. (novozymes.com)
  • Tabulates key information on the availability and specifications of international biological standards and international biological reference reagents. (who.int)
  • It is important to identify the nature of the patient's current and previous jobs, exposure to irritant or allergenic products, and physical environmental factors, such as temperature, humidity, airflow or exposure to ultraviolet light. (medscape.com)
  • Biotechnology is an interdisciplinary field that studies biological matter at cellular level. (idp.com)
  • In this review , we have discussed the general principles of designing and developing GM cells -based potency assays, including identification of cellular signaling pathways and detectable biological effects, generation of responsive cell lines and constitution of test systems, based on the current research progress. (bvsalud.org)
  • Literature that either focuses on the allele or contains information about function, biological role, cellular location, phenotype, regulation, structure, or disease homologs in other species for the allele or gene product. (yeastgenome.org)
  • Fingerprinting commercial products as well as Bt deposited in public collections was accomplished using a technique known as Cellular Fatty Acid analysis, based on Gas-Liquid Chromatography (GLC). (usda.gov)
  • North American and European scientists review the processes that control habitat availability, explore the issues impacting the quality of this habitat, and assess the biological factors affecting habitat use and the interaction between habitat quality and salmon reproductive success. (fisheries.org)
  • The estimated amount of time this product will be on the market is based on a number of factors, including faculty input to instructional design and the prior revision cycle and updates to academic research-which typically results in a revision cycle ranging from every two to four years for this product. (mheducation.com)
  • Moreover, the key factors which drive the market of the biological seed treatment product are its low-cost, scarcity of arable land, and the wide range of benefits provided by the biological seed treatment solutions. (reportsanddata.com)
  • Biological factors include different forms of disease organisms in food and water, and those that can be transmitted by insects and animals, and person-to-person contact. (cdc.gov)
  • Scientists usually attempt to quantify the rate of biological ageing - that is to say, how rapidly a person's cells and tissues are ageing - by measuring factors in the blood or changes to the DNA. (gowinglife.com)
  • Fourtanier A, Moyal D, Seite S. UVA filters in sun-protection products: regulatory and biological aspects. (unboundmedicine.com)
  • The agencies explain that strengthening their partnership and coordinating their efforts in this area "will help each agency address and deter anticompetitive behavior in the U.S. market for biological products…[which] might include anticompetitive reverse payment agreements, abusive regulatory filings, or misuse of restricted drug distribution practices. (mintz.com)
  • Patient-focused medical product development is a mechanism by which stakeholders, including but not limited to medical product developers, academics, and regulators, form a partnership with patients to enhance medical product development, throughout the research, regulatory, and reimbursement processes. (nationalhealthcouncil.org)
  • As stakeholders across the health care ecosystem embrace patient centeredness and integrate the patient voice into their processes, decisions, and organizations, meaningful patient engagement has become increasingly important during drug development, regulatory product review, and value assessment. (nationalhealthcouncil.org)
  • This approach does not change the applicable regulatory standards, such as the device approval or clearance standards, nor the applicable requirements, including premarket submission content requirements, the requirement for valid scientific evidence, and the FDA's gold standard for product review. (fda.gov)
  • Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. (elsevier.com)
  • There's a multi-billion-dollar yearly trade in medicines, foodstuffs and industrial products derived from plants, animals, fungi and bacteria. (earthjournalism.net)
  • The F.D.A. is responsible for the safety of most food products and medicines. (51voa.com)
  • Efficacy studies are conducted with a product batch formulated to the minimum approved potency (strength). (usda.gov)
  • Development and application of potency assays based on genetically modified cells for biological products. (bvsalud.org)
  • Potency assays are key to the development, registration, and quality control of biological products . (bvsalud.org)
  • The research presented in this review provides insights for the development and application of novel GM cells -based potency assays for biological products . (bvsalud.org)
  • Many technologies are used to characterize biological products, manufacturing processes, and raw materials. (bioprocessintl.com)
  • Few players, little product diversity, and a very narrow, inexpensive price range characterize the meat production industry status quo. (nextnature.net)
  • FDA and FTC are holding this public workshop to engage with stakeholders about certain aspects of a competitive market for biological products, including biosimilars and interchangeable products, and to discuss the important impact these products have on public health. (mintz.com)
  • FDA and FTC also encourage comments from stakeholders and the public relating to steps FDA and FTC can take to facilitate a competitive market for biological products. (mintz.com)
  • Increasing adoption of organic farming in the region is expected to drive the market for biological seed treatment solutions. (reportsanddata.com)
  • We started using liquid fertilizer blends and adding humic (acid), fulvic acid, kelp and various biological products like bacillus and other unique things like molasses to help break down thatch and spur microbial activity in our soils. (landscapemanagement.net)
  • Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Dongcheng District, Beijing 100050, China. (bvsalud.org)
  • When implants degrade or corrode, the immune system also responds to surface changes and degradation products. (medscape.com)
  • Rising demand in the agriculture sector for food grains and growing R&D to increase crop yield and seed potential is expected to drive the growth of the biological seed treatment market. (reportsanddata.com)
  • The rising need to increase the availability of plant nutrients in the root system is driving the demand for biological seed treatment solutions. (reportsanddata.com)
  • The growing focus on organic farming in the agricultural sector is most likely to fuel the demand for biological seed treatment over the forecast period. (reportsanddata.com)
  • At the same time that the agencies announced their Joint Statement and the FDA/FTC public workshop, FDA published a long-awaited draft guidance for industry entitled, "Promotional Labeling and Advertising Considerations for Prescription Biological Reference and Biosimilar Products: Questions and Answers. (mintz.com)
  • A. This procedure includes guidance on removing biological growth such as lichens, algae, mold and mildew from masonry and stucco. (gsa.gov)
  • This includes reducing or reforming outdated burdens that can add to development costs or forestall beneficial innovations without also adding to our assurance of safety or our knowledge about a product's benefits," said FDA Commissioner Scott Gottlieb, M.D. "Today, we're finalizing guidance that outlines how we're applying the 'least burdensome' means of assuring the safety and effectiveness of medical devices across the total product lifecycle. (fda.gov)
  • In a study including 11 cases where periprosthetic tissue contained corrosive elements (solid chromium orthophosphate corrosion products) after aseptic loosening of articular implants, immune-response tissue reactions were identified in every case. (medscape.com)
  • Thus nicotinamide is involved in numerous oxidation-reduction reactions in mammalian biological systems acting as an antioxidant. (enzolifesciences.com)
  • The cabinet offers a high level of personal and product protection from biological hazards and contamination, ease of use with an intuitive touchscreen display, and eco-friendly LED lighting for a brighter work environment. (labmanager.com)
  • Interacts with membrane insulin receptor to cause its biological actions. (sigmaaldrich.com)
  • We should also scrutinize nonoccupational sources, including hobbies and leisure activities, and domestic exposures, such as personal skin care products and fragrances, clothing and accessories, plants, and previous and current treatments. (medscape.com)
  • People who consumed raw milk or raw milk products from this dairy since January 2016 may have been exposed. (cdc.gov)
  • Please see the diagram below for information on developing an evaluation and treatment plan for patients who consumed raw milk or raw milk products from Miller's Biodiversity Farm since January 2016, and are still within the six-month window following their last known exposure . (cdc.gov)
  • Different biological effects have been allocated to propolis extracts by earlier studies and their phytoconstituents have been extensively characterised, especially flavonoids, polyphenols, phenolic aldehydes, sesquiterpene quinines, coumarins, amino acids, steroids and inorganic compounds. (bl.uk)
  • All crudes extracts, fractions as well as 12 isolated compounds then were subjected for biological testing against Trypanosoma, T. brucei S427 WT, and their cytotoxicity against mammalian cells was also determined. (bl.uk)
  • Jagdish Patel worked with Canadian scientists to identify a natural product from actinomycete extracts that might be useful in combating cancer. (uidaho.edu)
  • You must provide a thorough description of the product you are intending to import, including identification to both genus and species level wherever possible. (agriculture.gov.au)
  • This web page provides the public with summaries of safety and effectiveness (efficacy) studies used to license a particular USDA-regulated veterinary biological product. (usda.gov)
  • The Thermo Scientific 1500 Series Biological Safety Cabinet (BSC) combines safety, energy efficiency, and user convenience for today's modern laboratory. (labmanager.com)
  • This video will explain how to safely operate your Labconco Logic+ or Axiom biological safety cabinet. (labconco.com)
  • All labels describing substances in a product must be truthful. (51voa.com)
  • Il s'agit d'une source d'informations unique sur les substances chimiques fabriquées et importées en Europe. (europa.eu)
  • Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that have been used in consumer products around the world since about the 1950s. (medlineplus.gov)
  • Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay. (bvsalud.org)
  • ASP is not responsible for the content of the Third-Party Site and does not guarantee or endorse the information, recommendations, products or services offered on any Third-Party Site unless expressly stated by ASP. (asp.com)
  • Please let us know what you think of our products and services. (mdpi.com)
  • Educational webinars on Lime Works .us products, services, and hands-on workshops. (limeworks.us)
  • Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms - with the latter requiring reconstitution in the clinical setting. (bioprocessintl.com)
  • METHODS: For the 135 countries that have ever used asbestos , per capita asbestos use (kilograms per capita per year) was compared with per capita gross domestic product (GDP) in 1990 Geary-Khamis dollars (GKD) for the period 1920-2003. (cdc.gov)
  • When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online). (rndsystems.com)
  • MBG excels in basic research, answering key biological questions with application in understanding the molecular basis of human diseases. (europa.eu)
  • Growing awareness among consumers regarding the adverse effect of synthetic chemicals has resulted in the increasing adoption of biological seed treatment solutions. (reportsanddata.com)
  • Here, we employ DNA nanotechnology to design a synthetic enzyme that substantially outperforms its biological archetypes. (nature.com)
  • Consumers can buy synthetic cannabinoids in convenience stores, from individual drug dealers, friends, or online as incense or natural herbal products. (cdc.gov)
  • The current working hypothesis is that brodifacoum was mixed with synthetic cannabinoids products. (cdc.gov)
  • The global Biological Seed Treatment market is forecasted to grow at a rate of 11.2%, from USD 914.3 million in 2019 to USD 2,037.5 million in 2027. (reportsanddata.com)
  • Seed enhancement accounted for the largest market share in the biological seed treatment market in 2019 and is expected to maintain steady growth over the forecast period. (reportsanddata.com)
  • North America accounted for the largest market share in the biological seed treatment market in 2019. (reportsanddata.com)
  • Emerging products have been directly targeted at youth using icons such as famous musicians, actors and models for paid social media content. (com.pk)
  • In nuclear power plant decommissioning large components, such as reactor pressure vessel (RPV), RPV internals, steam generators and the biological shield, form the critical path of the decommissioning schedule. (fortum.com)
  • Propolis is also receiving ample attention in the context of initiatives to discover novel drugs, thanks to its biological and pharmacological qualities. (bl.uk)
  • For the most part, scientists and ethicists say introduced species are a danger to the ecosystem, but that may not be the case for biological pest control. (saferbrand.com)
  • Today, we are taking it another step further to increase root hair mass by using acetate-based products that are fertilizer catalysts and that help release nutrients, indolebutyric acid and kinetin and root-promoting peptides. (landscapemanagement.net)
  • Typically a Product Summary will contain an efficacy study summary for each microbial agent/disease against which the product is claimed to be effective. (usda.gov)
  • Products may be considered effective without producing 100% protection against disease. (usda.gov)
  • Many products instead reduce the severity of disease. (usda.gov)
  • Here , researchers trained a deep neural network to estimate rates of biological ageing and disease risk using motion data from wearable/carriable devices, such as smart watches and smartphones. (gowinglife.com)
  • This allows you to engage with biological psychology through a range of real world applications, getting you to apply your learning to conditions such as epilepsy, PTSD and Parkinson's, and treatments such as gene therapy and brain-computer interfaces for spinal cord injuries. (sagepub.com)
  • The two products contain bacterial consortia and nutrients and were used as supplementary additives to enhance the biodegradation rate and extent of hydrocarbon compounds. (concordia.ca)
  • True" Bugs - A variety of true bugs, defined as insects that suck up juicy nutrients rather than rending it with mouth parts, can be used in biological pest control. (saferbrand.com)
  • Herbal therapies can be natural or biological with practices or products made of herbs and nutrients like antioxidants and vitamins. (safemenopausesolutions.com)
  • Shandong Radisson Biological Technology Co. Ltd. (tradekey.com)
  • Shandong Radisson Biological Technology Co. Ltd.was established in ***4, is completely dedicated to the manufacture of high quality pharmaceutical raw materials of Hyaluronic acid (Sodium Hyaluronate or HA), Chondroitin Sulfate, and Biological Products of hyaluronic acid Filler, skin care products, beauty and health capsules, etc. (tradekey.com)
  • Since the Food and Drug Administration Modernization Act of 1997 (FDAMA), Congress has directed FDA to take a "least burdensome" approach to aspects of medical device premarket evaluation in a manner that eliminates unnecessary burdens that may delay the marketing of beneficial new products. (fda.gov)
  • Purifier Logic+ Class II, Type A2 Biosafety Cabinets provide personnel, product and environmental protection from hazardous particulates such as agents that require Biosafety Level 1, 2 or 3 containment. (labconco.com)
  • Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition. (medlineplus.gov)
  • This least burdensome definition considers the type of information, different approaches to generating or providing information, and when-during the total product lifecycle-information should be generated or provided to the FDA. (fda.gov)
  • Most products out there deplete and strip your natural skin resources while attempting to solve the problems of aging, and wear and tear. (dnaskin.com)
  • Hard materials (metals) and specialty steels now account for more than half of Swedish materials sales (excluding forest products), while glass and energy materials are the strongest growth areas. (abbaworld.com)
  • The facility bases many of its products on the manipulation of copper sheets and/or the use of abrasive-blasting to engrave impressions on stock materials. (cdc.gov)
  • With Univar Solutions' dedicated industry team, supply chain expertise, and global network of innovative laboratories, together we are well-positioned to help customers develop innovative products that use raw materials more efficiently, reduce energy consumption and replace traditional chemicals with more sustainable alternatives. (novozymes.com)
  • ASP is dedicated to providing a complete solution of STERRAD ® System sterilizers and compatible biological indicators. (asp.com)
  • Established in 2013 , we, Norvamed are well known Exporter and Manufacturer and Supplier and Trading Company of biological indicators, name label etc. (tradeindia.com)
  • 2] According to Huber et al, the presence of corrosion products and a hypersensitivity reaction in patients suggests that there is a relation between corrosion and implant-related hypersensitivity. (medscape.com)
  • Media can play a strong role to counter the deceptive campaigns of tobacco industry to promote harmful emerging tobacco products in Pakistani youth, said health activists during a consultation organized by Society for the Protection of the Rights of the Child (SPARC). (com.pk)
  • Prohibition of Smoking and Protection of Non-Smokers Ordinance 2002 provides key guidelines regarding advertisement, promotion and sale of tobacco products to children. (com.pk)
  • Shariq urged the media websites to take down these advertisements and raise awareness on harms of nicotine, second hand smoking, and adverse impacts of tobacco products on public economy and environment. (com.pk)
  • FDA also is responsible for the safety and security of our nation's food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products. (fda.gov)
  • As the biosimilar marketplace has expanded over the past several years, multiple companies have requested that FDA issue such guidelines to address perceived miscommunications by competitors about what biosimilars are or how they compare to the applicable reference biological products. (mintz.com)
  • References to products and suppliers serve as general guidelines and do not constitute a federal endorsement nor a determination that a product or method is the best alternative or compliant with current environmental regulations and safety standards. (gsa.gov)
  • Also, efficacy and safety data for some products licensed many years ago may no longer be available for various legitimate reasons. (usda.gov)
  • The lack of data for those products does not mean those products are any less efficacious or less safe than those products for which efficacy and safety data are available. (usda.gov)
  • Questions regarding product licensing data or the supporting regulation may be directed to [email protected] . (usda.gov)
  • These data demonstrate in vitro and in vivo that only well-balanced UVA-UVB sunscreens, absorbing over the entire UV spectrum are able to prevent or significantly reduce the associated biological damage. (unboundmedicine.com)
  • View more applications data for this product in our Scientific Poster Library . (biolegend.com)
  • USDA policy has evolved over the years to address increasing scientific knowledge and demands for product quality. (usda.gov)