Biological products. Medical search

Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.

ATPases that are members of the AAA protein superfamily (ATPase family Associated with various cellular Activities). The NSFs functions, acting in conjunction with SOLUBLE NSF ATTACHMENT PROTEINS (i.e. SNAPs, which have no relation to SNAP 25), are to dissociate SNARE complexes.

Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)

A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of medical care.

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The reduction or regulation of the population of noxious, destructive, or dangerous plants, insects, or other animals. This includes control of plants that serve as habitats or food sources for animal pests.

Use of naturally-occuring or genetically-engineered organisms to reduce or eliminate populations of pests.

The reduction or regulation of the population of noxious, destructive, or dangerous insects through chemical, biological, or other means.

Systems of agriculture which adhere to nationally regulated standards that restrict the use of pesticides, non-organic fertilizers, genetic engineering, growth hormones, irradiation, antibiotics, and non-organic ANIMAL FEED.

Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.

Bugs of the family CIMICIDAE, genus Cimex. They are flattened, oval, reddish insects which inhabit houses, wallpaper, furniture, and beds. C. lectularius, of temperate regions, is the common bedbug that attacks humans and is frequently a serious pest in houses, hotels, barracks, and other living quarters. Experiments have shown that bedbugs can transmit a variety of diseases, but they are not normal vectors under natural conditions. (From Dorland, 27th ed; Borror, et al., An Introduction to the Study of Insects, 4th ed, p272)

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.

Exclusive legal rights or privileges applied to inventions, plants, etc.

Sequential operating programs and data which instruct the functioning of a digital computer.

A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.

Method of analyzing chemicals using automation.

Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)

Computer-based representation of physical systems and phenomena such as chemical processes.

A plant genus of the family ONAGRACEAE. Members contain oenotheins.

Individuals responsible for various duties pertaining to the medical office routine.

Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.

Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.

Infections with true tapeworms of the helminth subclass CESTODA.

A subclass of segmented worms comprising the tapeworms.

A plant genus of the family VIOLACEAE. Some species in this genus are called bouncing bet which is a common name more often used with SAPONARIA OFFICINALIS. Members contain macrocyclic peptides.

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.

BIOLOGIC PRODUCTS that are imitations but not exact replicas of innovator products.

The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Laws concerned with manufacturing, dispensing, and marketing of drugs.

Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.

The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.

An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.

Procedures that render the female sterile by interrupting the flow in the FALLOPIAN TUBE. These procedures generally are surgical, and may also use chemicals or physical means.

Procedures to block or remove all or part of the genital tract for the purpose of rendering individuals sterile, incapable of reproduction. Surgical sterilization procedures are the most commonly used. There are also sterilization procedures involving chemical or physical means.

A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.

Procedures to reverse the effect of REPRODUCTIVE STERILIZATION and to regain fertility. Reversal procedures include those used to restore the flow in the FALLOPIAN TUBE or the VAS DEFERENS.

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.

Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The removal of LEUKOCYTES from BLOOD to reduce BLOOD TRANSFUSION reactions and lower the chance of transmitting VIRUSES. This may be performed by FILTRATION or by CYTAPHERESIS.

The collective name for the boron hydrides, which are analogous to the alkanes and silanes. Numerous boranes are known. Some have high calorific values and are used in high-energy fuels. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Changes of neonatal mortality rate between 'pre' and 'post' surfactant period. (1/1706)

The objective of this study was to determine how the neonatal mortality rate has changed since surfactant (S) therapy was introduced in our Neonatal Intensive Care Unit (NICU), and to evaluate the efficacy of surfactant therapy in respiratory distress syndrome (RDS) patients. Incidences of risk babies such as outborns, prematurity, low birth weight infants and RDS, and neonatal mortality rates were compared between 'pre' (control, 1988 to 1991, n=4,861) and 'post' S period (study, 1993 to 1996, n=5,430). In RDS patients of 'post' S period, neonatal mortality rate was compared between S-treated and non-treated patients, and chest X-ray and ventilatory parameters were compared between pre- and post-72 hr of surfactant treatment. Surfactant therapy showed short term effects, judging by the decrease of early neonatal deaths and improvement of chest X-ray and ventilatory parameters in RDS patients. The overall neonatal mortality rate had a tendency to decrease in spite of increased incidences of risk babies in 'post' S period but it was less than expected. The reasons were thought to be that we had a high proportion of risk babies, and there was some bias in patient selection for surfactant therapy and its use. In conclusion, with the active prevention of risk baby delivery and appropriate use of surfactant, better results could be expected. (+info)

Surfactant treatment for acute respiratory distress syndrome. (2/1706)

OBJECTIVE: To determine prospectively the efficacy of surfactant in acute respiratory distress syndrome. STUDY DESIGN: Twenty patients, 1 month to 16 years of age, diagnosed with an acute pulmonary disease with severe hypoxaemia (PaO2/FiO2 < 100) (13 with systemic or pulmonary disease and seven with cardiac disease) were treated with one to six doses of 50-200 mg/kg of porcine surfactant administered directly into the trachea. The surfactant was considered to be effective when the PaO2/FiO2 improved by > 20%. RESULTS: After initial surfactant administration the PaO2/FiO2 increased significantly in patients with systemic or pulmonary disease from 68 to 111, and the oxygenation index (OI) diminished significantly from 36.9 to 27.1. The PaO2/FiO2 and OI did not improve in children with cardiac disease. The improvement of the patients who survived was greater than that of those who died. CONCLUSIONS: Surfactant moderately improves oxygenation in some children with severe acute respiratory distress syndrome secondary to pulmonary or systemic disease. (+info)

Preclinical development strategies for novel gene therapeutic products. (3/1706)

With over 220 investigational new drug applications currently active, gene therapy represents one of the fastest growing areas in biotherapeutic research. Initially conceived for replacing defective genes in diseases such as cystic fibrosis or inborn errors of metabolism with genes encoding the normal, or wild-type, gene product, gene therapy has expanded into other novel applications such as treatment of cancer or cardiovascular disease, where the risk:benefit profiles may be more acceptable in relation to the severity of the disease. Different types of vectors, including modified retroviruses, adenoviruses, adenovirus-associated viruses, and herpesviruses and plasmid DNA, are used to transfer foreign genetic material into patients' cells or tissues. Developing a toxicology program to determine the safety of these agents, therefore, requires a modified approach that encompasses the pharmacology and toxicity of both the gene product itself and the vector system used for delivery in the context of the application for the clinical trial. In general, the issues involved in designing and developing appropriate preclinical testing to determine the safety of these products are similar to those encountered for other recombinant molecules, including protein biotherapeutics. Limitations to some of the typical toxicology studies conducted for a traditional drug development program may exist for these agents, and nontraditional approaches may be required to demonstrate their safety. Many factors may affect the safety and clinical activity of these agents, including the route, frequency, and duration of exposure and the type of vector employed. Other safety considerations include quantitation of the duration and degree of expression of the vector in target and other tissues, the effects of gene expression on organ pathology and/or histology, evaluation of trafficking of gene-transduced cells or vector after injection, and interactions of the host immune system with the transduced cell population. Because of the unique concerns regarding each of these therapies, the Center for Biologics Evaluation and Research encourages sponsors to obtain toxicity data whenever possible while evaluating the pharmacologic activity of the vector in a species or animal model relevant to their clinical indication. Sponsors are encouraged to discuss preclinical study design and results with the Center during product development to facilitate early identification of safety concerns prior to entry of these novel agents into the clinical setting and to ensure an uninterrupted course of development while addressing issues required for licensure. (+info)

Regulatory decision strategy for entry of a novel biological therapeutic with a clinically unmonitorable toxicity into clinical trials: pre-IND meetings and a case example. (4/1706)

The following material was derived from a synthesis of case histories taken from investigational new drug (IND) applications and drug sponsors' experiences, utilizing fictionalized data to avoid any resemblance to any proprietary information; any such resemblance is accidental. These examples are used as an instructional scenario to illustrate appropriate handling of a difficult toxicology issue. In this scenario, a drug caused a toxicity in animals that was detected only by histopathologic analysis; if it were to develop in patients, no conventional clinical methods could be identified to monitor for it. It is not unusual for a firm to cancel clinical development plans for a lead drug candidate that causes such a toxicity, especially if such a drug is intended for use as a chronic therapeutic in a population of patients with a chronic disease. This case synthesis was inspired by a Food and Drug Administration (FDA) agreement to allow such a product to proceed into clinical trials after substantive pre-IND discussions and agreement on well-considered toxicology program designs. The scientists most closely involved in the strategy development included the sponsor's toxicologist, veterinary toxicologic pathologist, and pharmacokineticist, as well as the FDA's reviewing pharmacologist. The basis of this decision was thorough toxicity characterization (1-month studies in 2 species); correlating toxicities with a particular cumulative area under the curve (AUC) in both species; identification of the most sensitive species (the species that showed the lower AUC correlating with toxicity); allometric assessment of clearance of the drug in 3 nonhuman species; construction of a model of human kinetics (based on extrapolation from animal kinetics); and finally, estimation of clinical safety factors (ratios of the human estimated cumulative AUC at the proposed clinical doses, over the animal cumulative AUC that correlated with the no adverse effect levels). Industry and FDA scientists negotiated a joint assessment of risk and benefit in patients, resulting in the FDA permitting such a compound to enter into clinical trials for a serious autoimmune disease. Such constructive, early communication starts with the pre-IND meeting, and the conduct and planning for this meeting can be very important in establishing smooth scientific and regulatory groundwork for the future of a drug under IND investigation. (+info)

Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond. (5/1706)

Many scientific discussions, especially in the past 8 yr, have focused on definition of criteria for the optimal assessment of the preclinical toxicity of pharmaceuticals. With the current overlap of responsibility among centers within the Food and Drug Administration (FDA), uniformity of testing standards, when appropriate, would be desirable. These discussions have extended beyond the boundaries of the FDA and have culminated in the acceptance of formalized, internationally recognized guidances. The work of the International Committee on Harmonisation (ICH) and the initiatives developed by the FDA are important because they (a) represent a consensus scientific opinion, (b) promote consistency, (c) improve the quality of the studies performed, (d) assist the public sector in determining what may be generally acceptable to prepare product development plans, and (e) provide guidance for the sponsors in the design of preclinical toxicity studies. Disadvantages associated with such initiatives include (a) the establishment of a historical database that is difficult to relinquish, (b) the promotion of a check-the-box approach, i.e., a tendancy to perform only the minimum evaluation required by the guidelines, (c) the creation of a disincentive for industry to develop and validate new models, and (d) the creation of state-of-the-art guidances that may not allow for appropriate evaluation of novel therapies. The introduction of biotechnology-derived pharmaceuticals for clinical use has often required the application of unique approaches to assessing their safety in preclinical studies. There is much diversity among these products, which include the gene and cellular therapies, monoclonal antibodies, human-derived recombinant regulatory proteins, blood products, and vaccines. For many of the biological therapies, there will be unique product issues that may require specific modifications to protocol design and may raise additional safety concerns (e.g., immunogenicity). Guidances concerning the design of preclinical studies for such therapies are generally based on the clinical indication. Risk versus benefit decisions are made with an understanding of the nature of the patient population, the severity of disease, and the availability of alternative therapies. Key components of protocol design for preclinical studies addressing the risks of these agents include (a) a safe starting dose in humans, (b) identification of potential target organs, (c) identification of clinical parameters that should be monitored in humans, and (d) identification of at-risk populations. One of the distinct aspects of the safety evaluation of biotechnology-derived pharmaceuticals is the use of relevant and often nontraditional species and the use of animal models of disease in preclinical safety evaluation. Extensive contributions were made by the Center for Biologics Evaluation and Research to the ICH document on the safety of biotherapeutics, which is intended to provide worldwide guidance for a framework approach to the design and review of preclinical programs. Rational, scientifically sound study design and early identification of the potential safety concerns that may be anticipated in the clinical trial can result in preclinical data that facilitate use of these novel therapies for use in humans without duplication of effort or the unnecessary use of animals. (+info)

Are there environmental forms of systemic autoimmune diseases? (6/1706)

A large number of drugs and an increasing number of environmental agents reportedly result in the appearance of a number of autoantibodies and in many instances in the appearance of a range of autoimmune clinical syndromes. The major disorders so recognized have marked resemblances to the autoimmune disease systemic lupus erythematosus. The commonly used term is drug-induced lupus; a better term is drug-related lupus. There is considerable interest at the present time in an increasing number of environmental agents. There have been two epidemics in recent years--one in Spain to a contaminant of rapeseed oil and one in the United States to a contaminant of l-tryptophan that caused an eosinophilic myositis. It is important for physicians and others involved in health care to recognize the potential associations of these diseases of unknown cause or causes. (+info)

The role of the toxicologic pathologist in the preclinical safety evaluation of biotechnology-derived pharmaceuticals. (7/1706)

Biotechnology-derived pharmaceuticals, or biopharmaceuticals, represent a special class of complex, high molecular weight products, such as monoclonal antibodies, recombinant proteins, and nucleic acids. With these compounds, it is not appropriate to follow conventional safety testing programs, and the preclinical "package" for each biopharmaceutical needs to be individually designed. In addition to standard histopathology, the use of molecular pathology techniques is often required either in conventional animal studies or in in vitro tests. In this review, the safety evaluation of biopharmaceuticals is discussed from the perspective of the toxicologic pathologist, and appropriate examples are given of the use of molecular pathology procedures. Examples include the use of in situ hybridization to localize gene therapy vectors, the assessment of vector integration into genomic DNA by the polymerase chain reaction (PCR), and the use of immunohistochemistry to evaluate the potential cross-reactivity of monoclonal antibodies. In situ PCR techniques may allow for confirmation of the germ cell localization of nucleic acids and may therefore facilitate the risk assessment of germline transmission. Increased involvement with biopharmaceuticals will present challenging opportunities for the toxicologic pathologist and will allow for much greater use of molecular techniques, which have a critical role in the preclinical development of these compounds. (+info)

Structures of surfactant films: a scanning force microscopy study. (8/1706)

The alveolar lining layer is thought to consist of a continuous duplex layer, i.e., an aqueous hypophase covered by a thin surfactant film which is a monolayer with dipalmitoyl-phosphatidylcholine (DPPC) as its most important component. Findings obtained by electron microscopy and results from in vitro experiments suggest, however, that the structure and hence the structure-function relations of surfactant films are more complex. In order to better define their structures films of surfactants were studied by scanning force microscopy. Four different surfactants were spread on a Langmuir-Wilhelmy balance, and then transferred onto a solid mica plate by the Langmuir-Blodgett technique, under various states of film compression. Imaging of the films by scanning force microscopy was performed in the contact (repulsive) mode in air. The scanning force micrographs revealed that surfactant films are not homogeneous, but rather undergo phase transitions depending on the surface pressures. Even at comparable surface pressures different surfactants show quite different surface patterns. Differences in surface structure can even be observed in films containing surfactant proteins (SP)-B and SP-C. These observations give further evidence that the widely accepted hypothesis of a regular monolayer of phospholipids governing the surface tension probably does not hold true, but that the structure-function relationship of surface active surfactant films is even more complex than hitherto thought. (+info)

Since the product is perishable, producers must have immediate access to proper cold storage (e.g., a household refrigerator or ... Biological Reviews. 89 (2): 255-269. doi:10.1111/brv.12052. PMID 23855350. Albert, Stefan; Bhattacharya, Debashish; Klaudiny, ... "Value-added products from beekeeping. Chapter 6". Buttstedt, Anja; Moritz, Robin F. A.; Erler, Silvio (May 2014). "Origin and ... "Federal Government Seizes Dozens of Misbranded Drug Products: FDA warned company about making medical claims for bee-derived ...

https://en.wikipedia.org/wiki/Royal_jelly

"Approved Products - ACAM2000". www.fda.gov. Retrieved 2018-09-08. "Biological Threats". Emergent BioSolutions. Retrieved 2018- ... Smallpox is considered a biological threat. Biological agents are toxins or organisms that can cause illness or death in humans ... Exposure can come from an intentional biological terrorist attack, accidental release of the agent, or a natural accident. ... enhances the emergency preparedness of the United States against the use of smallpox as a dangerous biological weapon." The ...

https://en.wikipedia.org/wiki/ACAM2000

ISBN 1-4757-1856-X. John W. Blunt, Murray H. G. Munro (2013). Dictionary of Marine Natural Products. CRC Press. ISBN 0-8493- ... Biological Control. 44: 24. doi:10.1016/j.biocontrol.2007.10.005. Stewart, M; Capon, R. J.; Lacey, E; Tennant, S; Gill, J. H. ( ... Journal of Natural Products. 68 (4): 581-4. doi:10.1021/np049614y. PMID 15844954. Capon, R. J.; Stewart, M; Ratnayake, R; Lacey ... Journal of Natural Products. 70 (11): 1746-52. doi:10.1021/np0702483. PMID 17958395. Stewart, M; Capon, R. J.; Lacey, E; ...

https://en.wikipedia.org/wiki/Penicillium_striatisporum

doi:10.1016/S0034-4257(99)00023-1. Battersby AR (December 2000). "Tetrapyrroles: the pigments of life". Natural Product Reports ... Biological Bulletin. 136 (1): 54-62. doi:10.2307/1539668. JSTOR 1539668. Gilpin L (21 March 2001). "Methods for analysis of ... Willows RD (June 2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports. 20 (3): 327-41. doi: ... Biological Chemistry. 383 (11): 1769-78. doi:10.1515/BC.2002.198. PMID 12530542. S2CID 3099209. Eckhardt U, Grimm B, ...

https://en.wikipedia.org/wiki/Chlorophyll

"The fluid dynamical context of chemosensory behavior." The Biological Bulletin 198 (2000): 188-202. Legrand, C, K Rengefors, GO ... Journal of Natural Products. American Chemical Society (ACS). 80 (5): 1287-1293. doi:10.1021/acs.jnatprod.6b00860. ISSN 0163- ... The Biological Bulletin. 198 (2): 225-244. CiteSeerX 10.1.1.317.7878. doi:10.2307/1542526. JSTOR 1542526. PMID 10786943. ... Shimizu Excreted toxins may help deter predators and bacteria which are drawn in by phytoplankton waste products. Phytoplankton ...

https://en.wikipedia.org/wiki/Phycotoxin

The products are primarily marketed as biological and biochemical fertilizer catalysts that increase nutrient availability and ... In July 2012, Agricen entered a strategic partnership with Loveland Products, Inc., a provider of crop input products and part ... Loveland Products. Retrieved 7 January 2020. CS1 maint: discouraged parameter (link) Ruen, Jim (18 January 2017). "Biological ... Commercially available products in the United States include Accomplish LM, Extract Powered by Accomplish, Maritime, and Titan ...

https://en.wikipedia.org/wiki/Agricen

Nohara, T; Yahara, S.; Kinjo, J (1998). "Bioactive Glycosides from Solanaceous and Leguminous Plants". Natural Product Sciences ... March 2000). "Anti-herpes virus activity of Solanum steroidal glycosides". Biological & Pharmaceutical Bulletin. 23 (3): 363-4 ... "Wonderberry". Center for New Crops & Plant Products, Purdue University. Vasileiadis; Vasileios, P.; Robert, J.; Froud‐Williams ... a corn meal product). In the rest of Kenya, S. nigrum (managu) is eaten in a similar way. In Tanzania, S. nigrum (mnafu or ...

https://en.wikipedia.org/wiki/Solanum_nigrum

Washroom and Hygiene Products. Retrieved 2021-04-14. "Biological Safety: Disinfection , Office of Environmental Health and ... resistant products, such as Bayer AG's DK Excited Bacteriostatic agent Disinfectant Enveloped virus List of cleaning products# ... "List of cleaning products", Wikipedia, 2021-03-27, retrieved 2021-04-17 "Help & Support". www.lysol.com. Retrieved 2021-04-12 ... Disinfecting uses a chemical product, which is a process that kills the germs on the surfaces. In most situations, regular ...

https://en.wikipedia.org/wiki/Virucide

The compound is the first natural product that has in vivo potential against the T. brucei. Cynaropicrin is a compound with ... Its γ-butyrolactone ring is involved in most of its biological functions. The unsaturated carbonyl group on the lactone ring ... On hydrogenation products of cynaropicrin, the bitter principle of artichoke (Cynara scolymus L.)". Collection of Czechoslovak ... Mander, Lewis N. Liu, Hung-wen, 1952- (2012). Comprehensive natural products II : chemistry and biology. Elsevier. ISBN 978-1- ...

https://en.wikipedia.org/wiki/Cynaropicrin

No biological tests confirm major depression. In general, investigations are not repeated for a subsequent episode unless there ... Gordon Duff (31 May 2006). "Updated prescribing advice for venlafaxine (Efexor/Efexor XL)". Medicines and Healthcare products ... Adolf Meyer put forward a mixed social and biological framework emphasizing reactions in the context of an individual's life, ... The biopsychosocial model proposes that biological, psychological, and social factors all play a role in causing depression. ...

https://en.wikipedia.org/wiki/Major_depressive_disorder

Some laboratory research has investigated the biological activity of erythravine, but the relevance to effects in humans is ... Journal of Natural Products. 70 (1): 48-53. doi:10.1021/np060254j. PMID 17253849. Flausino Jr, OA; Pereira, AM; Da Silva ... Biological & Pharmaceutical Bulletin. 30 (2): 375-8. doi:10.1248/bpb.30.375. PMID 17268084. Faggion, Silmara Aparecida; Cunha, ...

https://en.wikipedia.org/wiki/Erythravine

Principal contributors Ya Cai (1994). Dictionary of natural products (1. ed.). London [u.a.]: Chapman & Hall. ISBN 0-412-46620- ... Kamel, Zeinat; Khalil, Mary S.; Shalaby, Ahmed M. (1989). "Calcium and the biological activities of twoStreptomyces species ... Agricultural and Biological Chemistry. 48 (8): 2163-2166. doi:10.1271/bbb1961.48.2163. ...

https://en.wikipedia.org/wiki/Streptomyces_violaceochromogenes

PMID 11548049.CS1 maint: multiple names: authors list (link) Dewick, P.M. (2009). Medicinal Natural Products, 3rd. Ed. Wiley. p ... Roberson, D.J. & Strobel, G.M. (1982). "Monocerin, a Phytotoxin from Exserohilum turcicum". Agricultural and Biological ... S2CID 22721253.CS1 maint: multiple names: authors list (link) Grove, J.F. & Pople M. (1979). "Metabolic Products of Fusarium ... Staunton, J., Weissman, K.J. (2001). "Polyketide biosyntheis: a millennium review". Natural Product Reports. 18 (4): 380-416. ...

https://en.wikipedia.org/wiki/Monocerin

Other biological functions for which CSGAGs are known to play critical functions in include inhibition of axonal growth and ... 2002). "Heparin and heparan sulfate: structure and function". Natural Product Reports. 19 (3): 312-331. doi:10.1039/B100916H. ... It is believed that through differences in enzyme activity and expression, the wide spectrum of biological functions mediated ... Heparan sulfate (HS) has numerous biological activities and functions, including cell adhesion, regulation of cell growth and ...

https://en.wikipedia.org/wiki/Glycosaminoglycan

... household product ingredient, industrial additive, personal care product/cosmetic ingredient, pesticide ingredient, plastic/ ... Burton G. W., Ingold K. U. (1981). "Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related ... Household Products Database. [2] Archived 2015-09-05 at the Wayback Machine.US EPA. InertFinder. [3]. US National Library of ... Some food companies have voluntarily eliminated BHT from their products or have announced that they were going to phase it out ...

https://en.wikipedia.org/wiki/Butylated_hydroxytoluene

Natural Product Letters. 6 (3): 181-185. doi:10.1080/10575639508043156. Kim, J.-C.; Choi, G. J.; Park, J.-H.; Kim, H. T.; Cho, ... Agricultural and Biological Chemistry. 55 (8): 2037-2042. doi:10.1080/00021369.1991.10870928. Harwooda, John S.; Cutler, Horace ... Journal of Asian Natural Products Research. 11 (11): 962-6. doi:10.1080/10286020903339614. PMID 20183261. Hudson, H. J. ( ...

https://en.wikipedia.org/wiki/Nigrospora_sphaerica

... is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia ... Isolation of norambreinolide from cigar tobacco". Agricultural and Biological Chemistry. 35 (9): 1461-1462. doi:10.1080/ ... Journal of Natural Products. 59 (2): 113-116. doi:10.1021/np960028h. CS1 maint: discouraged parameter (link) Kaneko, Hajime ( ...

https://en.wikipedia.org/wiki/Sclareolide

Journal of Biological Chemistry. 264 (20): 11744-11749. Dewick, Paul M (2009). Medicinal Natural Products: a biosynthetic ...

https://en.wikipedia.org/wiki/Spermine

Dewick, P. (2009). Medicinal Natural Products: A Biosynthetic Approach (3rd ed.). West Sussex, England: Wiley. p. 357. ISBN 978 ... Chemico-biological Interactions. 293: 115-123. doi:10.1016/j.cbi.2018.07.022. PMID 30086269. ... Dewick, P. (2009). Medicinal Natural Products: A Biosynthetic Approach (3rd ed.). West Sussex, England: Wiley. p. 358. ISBN 978 ... Product 7 is then oxidized to form the methylenedioxy ring from the ortho-methoxyphenol, via an O2-, NADPH- and cytochrome P450 ...

https://en.wikipedia.org/wiki/Berberine

The end product can also be moved to a secondary system - usually another composting step - to allow more time for mesophilic ... A composting toilet is a type of dry toilet that treats human waste by a biological process called composting. This process ... Compost products like compost tea and compost extracts have been found to have an inhibitory effect on Fusarium oxysporum, ... Composting toilets, together with the secondary composting step, produce a humus-like end product that can be used to enrich ...

https://en.wikipedia.org/wiki/Compost

Journal of Natural Products. 48 (4): 559-63. doi:10.1021/np50040a007. INIST:8569626. Maruyama, Hiroe; Sumitou, Yoshiki; ... Biological & Pharmaceutical Bulletin. 32 (7): 1244-50. doi:10.1248/bpb.32.1244. INIST:21802341. v t e. ...

https://en.wikipedia.org/wiki/Dihydrokaempferide

"Albatross mortality and associated bait loss in the Japanese longline fishery in the southern ocean." Biological Conservation ... "Fleet Safety Fact Sheet: Amendment 80 Factory Trawlers". CDC - NIOSH Publications and Products. August 10, 2015. Retrieved 2016 ... "Fleet Safety Fact Sheet: Freezer Longliners (2015-238)". CDC - NIOSH Publications and Products. September 10, 2015. Retrieved ...

https://en.wikipedia.org/wiki/Longline_fishing

Alternative splicing of transcription products". The Journal of Biological Chemistry. 272 (28): 17843-50. doi:10.1074/jbc. ... The Journal of Biological Chemistry. 270 (24): 14659-65. doi:10.1074/jbc.270.24.14659. PMID 7782328. Oda H, Nakabeppu Y, ... The Journal of Biological Chemistry. 277 (10): 8579-87. doi:10.1074/jbc.M110566200. PMID 11756418. Fujikawa K, Yakushiji H, ... The Journal of Biological Chemistry. 278 (39): 37965-73. doi:10.1074/jbc.M306201200. PMID 12857738. Kamiya H, Dugué L, ...

https://en.wikipedia.org/wiki/2-hydroxy-dATP_diphosphatase

Butler, Alison (2007). Biological Inorganic Chemistry: Structure & Reactivity. pp. 151-156. ISBN 978-1891389436. Van der Helm D ... Hider RC, Kong X (May 2010). "Chemistry and biology of siderophores". Natural Product Reports. 27 (5): 637-657. doi:10.1039/ ...

https://en.wikipedia.org/wiki/Rhodotorulic_acid

Volume III contains biological products." British Pharmacopoeia Chinese herbology Chinese Medical Herbology and Pharmacology ... ISBN 978-7-5067-7343-0 Biological Preparations, ISBN 978-7-5067-7336-2 General rules and common inactive ingredients, ISBN 978- ...

https://en.wikipedia.org/wiki/Pharmacopoeia_of_the_People's_Republic_of_China

Plant Biological and Molecular Processes; Plant Diseases; Plant Genetic Resources, Genomics, and Genetic Improvement; Quality ... and Utilization of Agricultural Products; Rangeland, Pasture, and Forages; Soil Resource Management; Veterinary, Medical, and ...

https://en.wikipedia.org/wiki/Henry_A._Wallace_Beltsville_Agricultural_Research_Center

... has been used to detect peroxide production in biological systems. As superoxide is produced, the number of ... Natural Product Reports. 25 (6): 1118-30. doi:10.1039/b717196j. PMC 2654777. PMID 19030605. Neupert W (1997). "Protein import ... An enzymic function for erythrocuprein (hemocuprein)". The Journal of Biological Chemistry. 244 (22): 6049-55. PMID 5389100. ... The Journal of Biological Chemistry. 269 (23): 16311-7. PMID 8206937. Gao B, Eisenberg E, Greene L (July 1996). "Effect of ...

https://en.wikipedia.org/wiki/Cytochrome_c

The Panel on Dietetic Products for the European Food Safety Authority reported safe daily limits of 2.82 mg/kg of body weight ... Hand CE, Honek JF (February 2005). "Biological chemistry of naturally occurring thiols of microbial and marine origin". Journal ... Genghof DS, Inamine E, Kovalenko V, Melville DB (November 1956). "Ergothioneine in microorganisms". The Journal of Biological ... The Journal of Biological Chemistry. 234 (5): 1195-8. doi:10.1016/S0021-9258(18)98157-3. PMID 13654346. Seebeck FP (May 2010 ...

https://en.wikipedia.org/wiki/Ergothioneine

Natural Product Reports. 18 (5): 503-19. doi:10.1039/a804532a. PMID 11699883. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6- ... The Journal of Biological Chemistry. 243 (10): 2665-72. PMID 4967958. van Heijenoort J (October 2001). "Recent advances in the ...

https://en.wikipedia.org/wiki/UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate_ligase

Bioactive Marine Natural Products (PDF). Full text. 2005: Springer.CS1 maint: location (link) "Awards and Honors". Central Drug ... 101-. ISBN 978-1-4615-9322-5. S.W. Pelletier (22 October 2013). Alkaloids: Chemical and Biological Perspectives. Elsevier. pp. ... Bhakuni has documented his researches in a book, Bioactive Marine Natural Products and over 300 articles published in peer- ... 334-. ISBN 978-0-08-086572-0. Dewan S. Bhakuni; D.S. Rawat (30 June 2006). Bioactive Marine Natural Products. Springer. pp. 101 ...

https://en.wikipedia.org/wiki/Dewan_Singh_Bhakuni

425 per product up to fifty products and a maximum of $20,000 per company.[4] For each product over fifty, the fee is $100, for ... limitations when the Fish and Wildlife service express a potential adverse effect on a particular species based on a biological ... Registration of pesticide productsEdit. Before a company can register its pesticide products with the EPA, it must know what ... If this NOA is not complete the product would not make it through customs. The NOA lists the identity of the product, the ...

https://en.m.wikipedia.org/wiki/Federal_Insecticide,_Fungicide,_and_Rodenticide_Act

In food web terminology, complexity is a product of the number of species and connectance.[70][71][72] Connectance is "the ... Linkages connect to nodes in a food web, which are aggregates of biological taxa called trophic species. Trophic species are ... biological, physical, and social interactions that affect, sustain, or are modified by living organisms, including humans".[77] ... as well as products secreted, excreted or exuded from organisms (e.g. extra-cellular polymers, nectar, root exudates and ...

https://en.wikipedia.org/wiki/Food_web

"Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas. 39 (8): 1065-70. ... As a result, structural proteins, resulting from polypeptide products of gag and gag-pol genes, that are necessary for the HIV ...

https://en.wikipedia.org/wiki/Indinavir

... includes not just the use of plant products, but may also include the use of animal and mineral products.[74] It is among the ... that has a biological or psychological effect on a patient may also have potential to possess dangerous biological or ... animal and fungal products, and minerals, including use of these products in traditional medical practices that may also ... FDA, Use Caution With Ayurvedic Products *^ Niggemann, B.; Grüber, C. (22 February 2003). "Side-effects of complementary and ...

https://en.wikipedia.org/wiki/Integrative_medicine

"β-Catenin". Sino Biological Inc.: Biological Solution Specialist. Reynolds AB (June 2011). "Epithelial organization: new ... These gene products are important in determining cell fates during normal development and in maintaining homeostasis, or they ... a tumor suppressor gene product), CSNK1A1, and GSK3B. Following phosphorylation of the N-terminal Ser and Thr residues of β- ...

https://en.wikipedia.org/wiki/Catenin

Gurib-Fakim, A.; Subratty, H.; Narod, F.; Govinden-Soulange, J.; Mahomoodally, F.. «Biological activity from indigenous ... Industrial Crops and Products. doi:10.1016/j.indcrop.2015.03.058. ... Biological & Pharmaceutical Bulletin. doi:10.1248/bpb.27.1814. ... Biological & Pharmaceutical Bulletin. doi:10.1248/bpb.27.216. ...

https://el.wikipedia.org/wiki/Αμινά_Γκουρίμπ

Biological decomposition accelerates and the microbiota mass increases at the expense of other organic matter, adversely ... The Rishi Kheti use cow products like buttermilk, milk, curd and its waste urine for preparing growth promoters. The Rishi ... Ladybirds consume aphids and are considered beneficial by natural farmers that apply biological control. ...

https://en.m.wikipedia.org/wiki/Natural_farming

... to analyze complex biological systems. QIAGEN Silicon Valley's first product, IPA, was introduced in 2003, and is used to help ... Resulting information can be used to build biological models, design experiments, or get up to speed in an area of research. ... "New Products: Randox Laboratories' Beta-Lactams Array; Ingenuity Systems' iReport". BioArray News. GenomeWeb. January 24, 2012 ... All QIAGEN Silicon Valley use the Ingenuity Knowledge Base, which contains biological and chemical interactions and functional ...

https://en.wikipedia.org/wiki/QIAGEN_Silicon_Valley

The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products,[1] including ... "Synthesis and biological evaluation of Vinca alkaloids and phomopsin hybrids". Journal of Medicinal Chemistry. 52 (1): 134-142 ... Sears, Justin E.; Boger, Dale L. (2015). "Total Synthesis of Vinblastine, Related Natural Products, and Key Analogues and ... "Recent applications of Cp2TiCl in natural product synthesis". Organic Chemistry Frontiers. 1 (1): 15-33. doi:10.1039/c3qo00024a ...

https://en.wikipedia.org/wiki/Vinca_alkaloids

"Proceedings of the Royal Society B: Biological Sciences. 276 (1654): 121-127. doi:10.1098/rspb.2008.0858. PMC 2614250. PMID ... The products of photosynthesis are called "assimilates". In ferns and most flowering plants, the mesophyll is divided into two ... Specialized cells that differ markedly from surrounding cells, and which often synthesize specialized products such as crystals ... minor veins collect the products of photosynthesis (photosynthate) from the cells where it takes place, while major veins are ...

https://en.m.wikipedia.org/wiki/Cauline

Blood products such as packed red blood cells, platelets, or fresh frozen plasma may also be used.[135] Other regulators of ... May 2002). "Hemorrhagic fever viruses as biological weapons: medical and public health management". Journal of the American ... "FDA warns consumers about fraudulent Ebola treatment products" (Press release). Archived from the original on 11 January 2017. ... In late 1989, Hazelton Research Products' Reston Quarantine Unit in Reston, Virginia, suffered an outbreak of fatal illness ...

https://en.m.wikipedia.org/wiki/Ebola_virus_disease

The Thatcher filing was then followed by an FDA filing by BRC Operations PTY Limited, with their BRC Software Product[8] in ... Neural network (biological). *Detection theory. *Intraoperative neurophysiological monitoring. *Neurochip. *Neurodegeneration. ...

https://en.wikipedia.org/wiki/Neurometrics

... the body of literature that used these approaches seem to have mistaken and interpreted mathematical artifacts as the products ...

https://en.wikipedia.org/wiki/DunningKruger_effect

"Cooking as a biological trait" (PDF). Comp Biochem Physiol a Mol Integr Physiol. 136 (1): 35-46. doi:10.1016/S1095-6433(03) ...

https://en.wikipedia.org/wiki/Paleolithic

Examples of these classifications include gender, nationality, ethnicity, language, genre, style, biological species, and form. ... I found that they formed invariant products of not one but two distinct kinds. ... The first group of limits were calculable a ...

https://en.wikipedia.org/wiki/Numerical_data

Series B, Biological Sciences. 365 (1541): 729-48. doi:10.1098/rstb.2009.0103. PMC 2817223. PMID 20124341.. ... Curiously, around half of the protein products of transferred genes aren't even targeted back to the chloroplast. Many became ... The Journal of Biological Chemistry. 271 (11): 6545-54. doi:10.1074/jbc.271.11.6545. PMID 8626459.. ... Some transferred chloroplast DNA protein products get directed to the secretory pathway[27] (though many secondary plastids are ...

https://en.m.wikipedia.org/wiki/Chloroplast_DNA

In this context, it is the current state of humanity's knowledge of how to combine resources to produce desired products, to ... including the possibility of the permanent alteration of our biological nature. These concerns are shared by other philosophers ... Many technological processes produce unwanted by-products known as pollution and deplete natural resources to the detriment of ... "New products, new industries, and more jobs require continuous additions to knowledge of the laws of nature ... This essential ...

https://en.m.wikipedia.org/wiki/Technological

Biomechanics is the study of the structure and function of biological systems by means of the methods of Mechanics. ... Throughout history and in Europe right until the late 18th century, not only animal and plant products were used as medicine, ... Biophysics is an interdisciplinary science that uses the methods of physics and physical chemistry to study biological systems. ... Histology is the study of the structures of biological tissues by light microscopy, electron microscopy and ...

https://en.wikipedia.org/wiki/Medical

The maximum value of U is the product of the sample sizes for the two samples. In such a case, the "other" U would be 0. ... Biological Reviews of the Cambridge Philosophical Society. 82 (4): 591-605. doi:10.1111/j.1469-185X.2007.00027.x. PMID 17944619 ...

https://en.wikipedia.org/wiki/Mann-Whitney_U_test

... biological) material. Specifically, diagenesis "is the cumulative physical, chemical and biological environment; these ... This transformation occurs in the first few hundred meters of burial and results in the creation of two primary products: ... or biological change undergone by a sediment after its initial deposition, after its lithification. This process excludes ...

https://en.wikipedia.org/wiki/Diagenesis

"Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas. 40 (4): 443-56. ... a product should be sprayed on the tick to cause it to freeze and then drop off.[142] A doctor would use liquid nitrogen, but ... Newby, Kris (2019). Bitten: the Secret History of Lyme Disease and Biological Weapons. HarperCollins. ISBN 9780062896278. .. ... epidemiologist Jorge Benach provided Willy Burgdorfer, a researcher at the Rocky Mountain Biological Laboratory, with ...

https://en.wikipedia.org/wiki/Lyme_disease

"Proceedings of the Royal Society B: Biological Sciences. 278 (1708): 1090-1097. doi:10.1098/rspb.2010.1579. PMC 3049027. PMID ... Humans' extensive 'technosphere', now reaches ~30 Tt, including waste products from non-renewable resources.. ... "Secretariat of the Convention on Biological Diversity. Retrieved 9 January 2017.. *^ Glowka, Lyle; Burhenne-Guilmin, Françoise ... We have driven the rate of biological extinction, the permanent loss of species, up several hundred times beyond its historical ...

https://en.m.wikipedia.org/wiki/Sixth_mass_extinction

Product[edit]. Processing[edit]. A combination of gravity, screens and air flow is used to clean and sort lentils based on ... Biological nitrogen fixation or other rotational effects could be the reason for higher yields after lentils.[11] ...

https://en.wikipedia.org/wiki/Lentils

"ASTM Products and Services. Retrieved 15 June 2014.. *^ a b "ASTM F3208 - 17 Standard Guide for Selecting Test Soils for ... "11.100.20: Biological evaluation of medical devices". Retrieved 10 April 2009.. *^ International Organization for ... "ASTM International Products and Services. Retrieved 15 June 2014.. *^ "Standard Practice for Reporting and Assessment of ... "ASTM International - Products and Services. Retrieved 15 June 2014.. *^ "Standard Guide for Blood Cleaning Efficiency of ...

https://en.m.wikipedia.org/wiki/Medical_device

Lithium naturally only occurs in traces in biological systems and has no known biological role, but does have effects on the ... Francium-223, the only naturally occurring isotope of francium,[58][59] is the product of the alpha decay of actinium-227 and ... Biological role and precautionsEdit. MetalsEdit. Pure alkali metals are dangerously reactive with air and water and must be ... Rubidium has no known biological role, but may help stimulate metabolism,[234][235][236] and, similarly to caesium,[234][237] ...

https://en.m.wikipedia.org/wiki/Alkali_metal

The three major histatins are 1, 3, and 5. Histatin 2 is a degradation product of histatin 1, and all other histatins are ... "The Journal of Biological Chemistry. 263 (16): 7472-7477. ISSN 0021-9258. PMID 3286634.. .mw-parser-output cite.citation{font- ... degradation products of histatin 3. Therefore there are only two genes, HTN1 and HTN3. ...

https://en.wikipedia.org/wiki/Histatin

Earthjustice, the Sierra Club, the Center for Biological Diversity and other environmental groups announced a campaign in 2015 ... Products. Coal. Revenue. $ 4.2 billion (FY 2012)[2]. Operating income. $ (682) million (FY 2012)[2]. ...

https://en.wikipedia.org/wiki/Arch_Coal

Biological data visualization. *Chemical imaging. *Crime mapping. *Data visualization. *Educational visualization. *Flow ... Product visualization. *Scientific visualization. *Software visualization. *Technical drawing. *User interface design. *Visual ...

https://en.wikipedia.org/wiki/Computer_graphics_

These differences probably reflect some biological differences as well as differences in pathologic diagnosis and reporting.[51 ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ...

https://en.m.wikipedia.org/wiki/Brain_tumors

Standard Terminology Of Ceramic Whiteware and Related Products. ASTM Standard C242. *^ Mason, Robert B. (1995). "New Looks at ... mirip dengan pakaian dipakai oleh askar-askar moden untuk perlindungan terhadap senjata biological, kimia dan nukelar. Oleh ...

https://ms.wikipedia.org/wiki/Reka_cipta_pada_zaman_pertengahan_Islam

... Page Content. Overview. Human cells, tissues, and cellular and tissue-based products (HCT/Ps) that do not ... Some examples of HCT/Ps regulated as biological products are listed below: *. Allogeneic peritoneal membrane product in guided ... Home , Advocacy , Regulatory Affairs , Cellular Therapies , Biological Products Home , Advocacy , Regulatory Affairs , Cellular ... 351 products. For these HCT/Ps regulated as biological products, the FDA requires premarket review of safety and efficacy data ...

http://www.aabb.org/advocacy/regulatorygovernment/ct/biologicalproducts/Pages/default.aspx

... immunoglobulin products, products containing cells or microorganisms, and most protein products. Biological products subject to ... What is a biological product? Biological products, like other drugs, are used for the treatment, prevention or cure of disease ... Are the biologic development requirements different than the requirements for a new drug product? Biological products are a ... A sponsor may be able to demonstrate product comparability between a biological product made after a manufacturing change and a ...

https://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/TherapeuticBiologicApplications/ucm113522.htm

A) A copy of all adverse biological product experience reports submitted to the licensed manufacturer of the final product;. (B ... Any adverse event associated with the use of a biological product in humans, whether or not considered product related, ... Unexpected adverse experience: Any adverse experience that is not listed in the current labeling for the biological product. ... Expedited Safety Reporting Requirements for Human Drug and Biological Products. AGENCY: Food and Drug Administration, HHS.. ...

https://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/ucm120262.htm

The development and manufacture of biopharma products is set to be one of the fastest growing sections of the industry. ... The rapidly changing international regulatory demands and expectations for these products. *How these requirements can be ... "Excellent overview of production of biotech products!"Sandra Grote / Beverborg, Organon, The Netherlands ... reduce product losses and improve yields? This course shows how - using case studies, team-based exercises and discussion of ...

http://www.nsf.org/training-education/training-entry/2019868-gmp-for-biological-and-biotechnology-products

This book presents an updated discussion of the chemical composition and biological properties of the main bee products. ... Bee Products - Chemical and Biological Properties. Editors. * José M. Alvarez-Suarez Copyright. 2017. Publisher. Springer ... Bee Products - Chemical and Biological Properties. Editors: Alvarez-Suarez, José M. (Ed.) ... Presents an updated discussion on the chemical composition and biological properties of the main bee products, which until now ...

https://www.springer.com/gp/book/9783319596884

Free Shipping and expert advice on a wide range of do it yourself pest control products, pest control supplies, pest control ...

https://www.domyownpestcontrol.com/koppert-biological-systems-m-190.html?features%255B10%255D=10&features%255B12%255D=12&features%255B11%255D=11&page=3

Proposed Categorization of Products-Proposed Order. Category I. Licensed biological products determined to be safe and ... The comment stated that because all biological products are prescription products administered by health care providers, the ... product standards, or other conditions necessary or appropriate for a biological products safety and effectiveness. ... PART 610-GENERAL BIOLOGICAL PRODUCTS STANDARDS. End Part 3. The authority citation for 21 CFR part 610 continues to read as ...

https://www.federalregister.gov/documents/2004/12/29/04-28322/biological-products-bacterial-vaccines-and-toxoids-implementation-of-efficacy-review

The present invention is to present a biological sample analyzer, comprising: a characteristic information obtainer for ... The present invention relates to a biological sample analyzer and computer program product for analyzing biological samples ... A computer program product for enabling a computer to control a biological sample analyzer, comprising: a computer readable ... A computer program product for enabling a computer to control a biological sample analyzer, comprising: a computer readable ...

http://www.freepatentsonline.com/y2009/0248317.html

... to revise and clarify procedures for application holders of an approved drug or biological product to change the product ... Licenses for biological products are to be issued only upon a showing that the biological product is safe, pure, and potent (42 ... include drugs approved under the FD&C Act and biological products licensed under the PHS Act, other than biological products ... FDAs regulations in 21 CFR part 201 apply to all prescription drug products, including biological products. ...

https://www.federalregister.gov/documents/2013/11/13/2013-26799/supplemental-applications-proposing-labeling-changes-for-approved-drugs-and-biological-products

... biochemical products market in China and the trend in recent years ... This report presents a clear picture about the overall development of biological & ... CHAPTER 1 PRODUCT DEFINITION. CHAPTER 2 MARKET SIZE. 2.1 Analysis On The Biological & Biochemical Products Market Size. 2.2 An ... Product definition. Biological & biochemical products mentioned in this report is a general concept, it shall include the ...

https://marketpublishers.com/report/medicine_pharmaceuticals_biotechnology/drugs_biotechnology/china_biological_biochemical_products_market_report.html

Find septic tank biological product articles on Environmental XPRT, the worlds largest environmental industry marketplace and ... septic tank biological product Articles. Related terms for "septic tank biological product ": septic tank articles ... All Products Services Software Training Applications Companies News Articles Books Magazines Events Downloads Videos ... This by-product is named as sludge. Typically in solid, semi-solid or liquid state, it is in fact an amalgamation of all the ...

https://www.environmental-expert.com/articles/keyword-septic-tank-biological-product-26968

Results for advanced biological wastewater treatment product equipment from Aero-Fac, BioMaxx, Dow FILMTEC and other leading ... advanced biological wastewater treatment product equipment Related terms for "advanced biological wastewater treatment product ... biological wastewater treatment equipment , biological wastewater treatment product equipment , advanced biological wastewater ... Bio Augmentation Products. Advanced/BIO is a new range of biological wastewater treatment products that contain both Bacteria ...

https://www.environmental-expert.com/products/keyword-advanced-biological-wastewater-treatment-product-70958

Compare Anti-NFASC Antibody Products from Sino Biological, Inc. from leading suppliers on Biocompare. View specifications, ... Selected Products. You havent selected any products. Find products. Stay up to date on news and special offers related these ... Anti-NFASC Antibody Products from Sino Biological, Inc.. Anti-NFASC antibodies are offered by a number of suppliers. This ... Biocompare is the leading resource for up-to-date product information, product reviews, and new technologies for life ...

https://www.biocompare.com/pfu/110447/soids/313123/Antibodies/NFASC?vids=104292

C) a biological product, the agency center charged with premarket review of biological products shall have primary jurisdiction ... iii) a biological product, the agency center charged with premarket review of biological products shall have primary ... M) the distribution of a collection of finished medical devices, which may include a product or biological product, assembled ... or biological product.. (B) The Secretary shall conduct the premarket review of any combination product under a single ...

http://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section353&num=0&edition=prelim

Find China Product Listings in Alphabetical Order on Alibaba.com for China Naturals Big, China Naturals Biological, China ... Browse Products Alphabetically: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9 ... China Naturals Biological. China Naturals Biology. China Naturals Black. China Naturals Blue. China Naturals Blues. China ... Browse by:Manufacturers - Online Shopping - China Gold Suppliers - All Products - Countries - Importers - Buying Leads - China ...

http://www.alibaba.com/countrysearch/CN/China/products/N_709.html

Start Early and Finish Strong with DiPel Biological Insecticide. Begin your growing season right with an early application of ... Leap ES Bacterial Disease Management / Biological Insecticide Emulsifiable Suspension Info Label/SDS ... Valent BioSciences LLC , Sumitomo Chemical Co., Ltd. , Valent Canada - Crop and Professional Products ...

https://www.valent.com/agriculture/products/dipel/index.cfm

Several categories of drugs are identical to or derived from biological products. Some hormones given as drugs, for example, ... Nomenclature for Biological Products Nomenclature for Biological Products. Chapter:. (p. 529) Nomenclature. Author(s):. ... Several categories of drugs are identical to or derived from biological products. Some hormones given as drugs, for example, ...

http://www.amamanualofstyle.com/view/10.1093/jama/9780195176339.001.0001/med-9780195176339-div2-411?rskey=yaJWjV&result=1&q=

"Reference product" is defined as the single biological product licensed under Section 351, Subsection (a) of the PHS Act ... The biological product and reference product utilize the same mechanism or mechanisms of action for the condition or conditions ... Biological Products Previously Approved as New Drugs. In general, a marketing application for a biosimilar product must be ... The biological product is highly similar to the reference product, notwithstanding minor differences in clinically inactive ...

https://www.morganlewis.com/pubs/healthcare-reform-law-a-new-regulatory-pathway-for-biosimilar-biological-products

such biological product is in a product class for which a biological product in such product class is the subject of an ... i) "Biological product" definedIn this section: (1) The term "biological product" means a virus, therapeutic serum, toxin, ... B) each package of the biological product is plainly marked with- (i) the proper name of the biological product contained in ... h) Exportation of partially processed biological productsA partially processed biological product which- (1) is not in a form ...

https://www.law.cornell.edu/uscode/text/42/262

... substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological ... The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a ... biological composition, or biological fluid obtained by the inventive method be an in vitro produced product, but will be ... said biological composition comprising at least one of a cell-containing biological composition and a biological fluid ...

http://www.google.com/patents/US6548242?dq=6446111

The subject of the invention is an elastin-based product consisting of an adduct containing elastin and at least one protein ... Elastin-based product, a procedure for its preparation and its biological applications; in particular as biomaterials and ... The invention also relates to a procedure for its preparation as well as to the biological applications of this product, in ... In the remainder of the text, the products thus prepared will also designated by the special description of biological patch. ...

http://www.google.co.uk/patents/US5223420

Fly Eliminators® - Biological Fly Control * How To Build Your Fly Control Program ...

https://www.arbico-organics.com/?a=2016

Development of mineral membranes and processes for separating biological fermentation products. New process for the preparation ... Development of a new process for the preparation of pharmaceutical products of fermentation, based on the use of new mineral ... of pharmaceutical products. of fermentation, based on new mineral membranes. characterised by their separating capacity ...

https://www.eurekanetwork.org/project/id/160

1) Biosimilar biological product development program fees. (A) Initial biosimilar biological product development fee. (i) In ... C) One fee per product per year. The biosimilar biological product fee shall be paid only once for each product for each fiscal ... ii) biosimilar biological product application fees under subsection (a)(2); and. (iii) biosimilar biological product program ... C) One fee per product per year. The biosimilar biological product program fee shall be paid only once for each product for ...

https://uscode.house.gov/view.xhtml?req=granuleid%3AUSC-prelim-title21-chapter9-subchapter7-partC-subpart8&saved=%7CZ3JhbnVsZWlkOlVTQy1wcmVsaW0tdGl0bGUyMS1zZWN0aW9uMzc5ai01MQ%3D%3D%7C%7C%7C0%7Cfalse%7Cprelim&edition=prelim

Predictive Analyses of Biological Effects of Natural Products: From Plant Extracts to Biomolecular Laboratory and Computer ... Roberto Gambari, "Predictive Analyses of Biological Effects of Natural Products: From Plant Extracts to Biomolecular Laboratory ...

https://www.hindawi.com/journals/ecam/2011/383290/cta/

Once considered a biological waste product, umbilical cord blood (UCB) has emerged as a viable source of haematopoietic stem ... Nevertheless, because of certain biological properties of UCB compared with bone marrow, UCB cells will grow or "engraft" in ... or total nucleated cell dose are surrogate measures of the stem cell dose in the transplant product. ...

https://www.mja.com.au/journal/2006/184/8/no-longer-biological-waste-product-umbilical-cord-blood

... Mohamed, Yasser Mahmoud Ali ... another PUFA derived marine natural product was used as a lead compound for making analogs that were subjected to biological ... Among those natural products, several polyunsaturated fatty acids (PUFAs) and their metabolites have been isolated.. This ... An efficient stereocontrolled synthesis of this natural product has been achieved. During the work towards the total synthesis ...

https://www.duo.uio.no/handle/10852/36040

Biological indicators - Part 7: Guidance for the selection, use and interpretation of results ... Sterilization of health care products - Biological indicators - Part 7: Guidance for the selection, use and interpretation of ... It does not specify requirements for the selection and use of biological indicators intended to monitor vaporised hydrogen ... This document provides guidance for the selection, use and interpretation of results from application of biological indicators ...

https://www.iso.org/standard/74113.html?browse=tc

China Industrial Dryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing, Find details about ... Home,Products,Microwave thawing machine,Dryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing ... Dryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing. *. Place of Origin:. Shandong, China ( ... offers a full range of Microwave thawing machine for microwave thawing applicationsDryer Vacuum Microwave products biological ...

http://www.epier.com/industrial-48277954-dryer-vacuum-microwave-products-biological-temperature-microwave-microwave-low-thawing.html

11 • December 2013 BRIEF REPORTS The Difference Between Statistical Significance and Biological Meaningfulness A recent paper1 ... The Difference Between Statistical Significance and Biological Meaningfulness The Durk Pearson & Sandy Shaw®. Life Extension ... Biological importance and statistical significance. J Agric Food Chem. 61:8340-8 (2013). ... The Difference Between Statistical Significance and Biological Meaningfulness. A recent paper1 discusses the importance of ...

https://life-enhancement.com/pages/the-difference-between-statistical-significance-and-biological-meaningfulness

If the clinical studies in humans demonstrate the biological product is safe and effective and the relative benefits outweigh the risks, the sponsor may pursue licensure by submitting a Biologics License Application (BLA). (aabb.org)
Whereas a new drug application (NDA) is used for drugs subject to the drug approval provisions of the FDC Act, a biologics license application (BLA) is required for biological products subject to licensure under the PHS Act. (fda.gov)
The Patient Protection and Affordable Care Act of 2010, as amended by the Health Care and Education Reconciliation Act of 2010 (the Healthcare Reform Law), establishes an abbreviated licensure pathway for biosimilar biological products, with provisions covering exclusivity periods, and payment for biosimilars. (morganlewis.com)
42 U.S.C. Section 262), which provides the statutory framework for Biologics License Applications (BLAs) to allow licensure of biological products as biosimilar or interchangeable. (morganlewis.com)
4)(A) Subject to subparagraph (B), the term 'biosimilar biological product application' means an application for licensure of a biological product under section 262(k) of title 42 . (house.gov)
iv) an application for licensure under section 262(k) of title 42 that is submitted by a State or Federal Government entity for a product that is not distributed commercially. (house.gov)
This guideline can be adopted as a whole, or partially, by NRAs worldwide or used as a basis for establishing national regulatory frameworks for licensure of these products. (who.int)
The repackaging of biological products not subject to licensure under section 351 is addressed in a separate draft guidance document. (gmp-compliance.org)

FDA regulations and policies have established that biological products include blood-derived products, vaccines, in vivo diagnostic allergenic products, immunoglobulin products, products containing cells or microorganisms, and most protein products. (fda.gov)
Most proteins intended for therapeutic use, including cytokines (e.g., interferons), enzymes (e.g. thrombolytics), and other novel proteins, except for those that are specifically assigned to the Center for Biologics Evaluation and Research (CBER) (e.g., vaccines and blood products). (fda.gov)
The report also goes into detail on the most commonly reported issues for non-blood products licensed by CBER, which include allergenic products, blood derivatives, IVDs, vaccines and licensed HCT/Ps. (raps.org)
For vaccines, which accounted for the highest number of reports in this category, FDA says it saw an increase in reports of products not meeting specification, most of which had to do with the product's appearance. (raps.org)
The Chapter applies to all biological medicinal products (reference products, biosimilars and related products) except for vaccines and advanced therapy medicinal products. (lexology.com)
Mixing, diluting, or repackaging of blood and blood components for transfusion, vaccines, cell therapy products, or gene therapy products The guidance does not alter FDA's existing approach to regulating the collection and processing of blood and blood components. (gmp-compliance.org)
In addition, FDA intends to consider regulatory action if licensed vaccines, cell therapy products, and gene therapy products are subject to additional manufacturing, including mixing, diluting, or repackaging, in ways not specified in the product's approved BLA as described in the approved labelling for the product. (gmp-compliance.org)
Active pharmaceutical ingredients (API), vaccines serum, and hematological products (whole blood and plasma derivatives), recombinant DNA products, cell cultures (micro-organisms or eukaryotic cells), gene therapy and cell therapy products, antigens, allergens, antivenoms, etc. are some examples of biological products. (sbwire.com)

The new chapter addresses the specific challenges of pharmacovigilance relating to biological medicinal products. (lexology.com)
The chapter entitled " Product- or population-specific considerations II: Biological medicinal products " ("the Chapter") came into effect on 16 August 2016. (lexology.com)
The Chapter is intended to be read alongside process-related GVP Modules that apply to all medicinal products, and highlights specific issues to be taken into account when monitoring and managing the safety of biological medicinal products post-authorisation. (lexology.com)
The Chapter outlines the roles and responsibilities of marketing authorisation holders, competent authorities and the EMA on how to better monitor and manage the safety of biological medicinal products. (lexology.com)
The particular risk areas identified in the Chapter that relate to biological medicinal products are immunogenicity, manufacturing variability, non-adherence to good distribution practices and product traceability. (lexology.com)
While all medicinal products have the potential to cause immunogenicity, the risk is greater for biological medicinal products and requires specific consideration. (lexology.com)
The Chapter provides that pre-marketing authorisation studies on biological medicinal products cannot usually adequately assess the risk of immunogenicity arising from all of these factors. (lexology.com)
The manufacturing variability risks relates to the fact that minor variations at various stages of the manufacturing process of biological medicinal products (such as changes in choice of cell line, starting materials, fermentation, purification) can have a significant effect on product quality, safety and efficacy. (lexology.com)
The safety of biological medicinal products may change over time for the same product, and the quality assessment of reference products may differ from that of biosimilars and related products. (lexology.com)
Quality of biological medicinal products may also differ between specific batches as a consequence of standards specified at later stages of the supply chain not being properly complied with such as storage and handing conditions, cold chain and good distribution practices. (lexology.com)
The Chapter further provides that non-adherence to appropriate storage and handling conditions, cold chain and good distribution practices may affect the stability and quality of biological medicinal products, which in turn may introduce or alter immunogenicity or contamination. (lexology.com)
Life-cycle pharmacovigilance is therefore an important aspect for biological medicinal products. (lexology.com)
Another key requirement for pharmacovigilance of biological medicinal products identified in the Chapter is the need to ensure continuous product and batch traceability in clinical use. (lexology.com)
The term "generic" medicine is used to describe chemical, small molecule medicinal products that are structurally and therapeutically equivalent to an originator product whose patent and/or data protection period has expired. (who.int)
The Central Drugs Standard Control Organization (CDSCO), India's Authority for Medicinal Product, has published a draft Guideline on Good Distribution Practice (GDP) for biological products. (gmp-compliance.org)
The distribution of medicinal products has called the attention of the regulators worldwide. (gmp-compliance.org)
This document is an annex to the guideline on similar biological medicinal products containing monoclonal antibodies: non-clinical and clinical issues . (europa.eu)
It lays down the non-clinical and clinical requirements for somatropin-containing medicinal products claiming to be similar to another one already marketed. (europa.eu)

Most wastewater treatment processes produce a by-product that purifies wastewater before it is released into local waterways. (environmental-expert.com)
These systems typically consist of a multi-stage treatment process that includes filtration, biological treatment, and disinfection of wastewater prior to discharge. (environmental-expert.com)
Membrane Bio-Reactor (MBR) is an advanced wastewater treatment technology which combines membrane separation with biological wastewater treatment. (environmental-expert.com)
GAC is used to adsorb small quantities of soluble organics and inorganic compounds such as nitrogen, sulfides and heavy metals remaining in the wastewater following biological or physical-chemical treatment. (environmental-expert.com)
Advanced/BIO is a new range of biological wastewater treatment products that contain both Bacteria and 'extremophile' microorganisms. (environmental-expert.com)
In this article, recent advances in predicting organic micropollutant abatement during ozonation of municipal wastewater effluents are reviewed with a focus on (i) principle-based approaches for describing and modeling the reaction kinetics of ozone and ˙OH, (ii) transformation products and pathways, (iii) changes of biological activities, and (iv) biodegradation of transformation products in biological post-treatment. (rsc.org)
Biological treatment has long been used in the treatment of wastewater. (kwrwater.nl)

However, only biological products are licensed under section 351 of the PHS Act. (fda.gov)
Reference product" is defined as the single biological product licensed under Section 351, Subsection (a) of the PHS Act against which a biological product is evaluated. (morganlewis.com)
Within this draft document, FDA shows their policy regarding the mixing, diluting, and repackaging of certain types of biological products that have been licensed under section 351 of the Public Health Service Act (PHS Act) when such activities are not within the scope of the product's approved biologics license application (BLA) as described in the approved labelling for the product. (gmp-compliance.org)

What's less well-known is that each year, hundreds of new inventions are produced in the laboratories of NIH, the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA), and these inventions are licensed out to private companies in the US and internationally for further research and development, with the hopes of bringing new products to market. (raps.org)
LAMPIRE Biological Laboratories specializes in polyclonal and monoclonal antibody development, cell culture devices and services, and a wide variety of blood-derived products. (lampire.com)
LAMPIRE Biological Laboratories, Inc., announced it has completed the acquisition of H. B. Custom Media, based out of the Ben Franklin Tech Ventures Business Center, in Bethlehem, PA. (lampire.com)
In that moment, life sciences company Lampire Biological Laboratories Inc. had found its name. (lampire.com)
Global Bovine Serum Albumin Market Top Players 2017: Lampire Biological Laboratories. (lampire.com)
However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. (ucsd.edu)
Immuno-Biological Laboratories Co., Ltd. (ibl-japan.co.jp)

This document provides guidance for the selection, use and interpretation of results from application of biological indicators when used in the development, validation and routine monitoring of sterilization processes. (iso.org)
It does not specify requirements for the selection and use of biological indicators intended to monitor vaporised hydrogen peroxide processes for isolator and room biodecontamination processes at atmospheric pressure. (iso.org)
This is due to the complexity of biological active substance molecules, and complexity of manufacturing processes with many steps that can each have an effect on product quality and safety. (lexology.com)
This Kat is grateful to his colleague Andrew Sharples , head of practice group EIP Life , for preparing this report of recent news from the European Patent Office about the patentability of products of essentially biological processes. (blogspot.com)
This decision did not go unnoticed by the powers of the EU, and in December 2015, the European Parliament adopted a resolution asking the European Commission to look into the patentability of products of essentially biological processes. (blogspot.com)
Nevertheless, the Commission has concluded that animals and plants derived from essentially biological processes should not be patentable. (blogspot.com)
Processes for importing products, organisms, or animals related to biological products are set out elsewhere on this website. (mpi.govt.nz)
Here the EBA conducted a lengthy and in-depth legal analysis leading to the conclusion that a narrow interpretation of Art 53(b) EPC was appropriate and as a result plants and animals derived from essentially biological processes were in principle patentable, even if they were inevitably derived from such processes. (blogspot.com)
The exclusion to patentability in the Biotech Directive is framed much like that in Article 53(b) EPC i.e. it expressly excludes from patentability essentially biological processes for the production of plants and animals but does not mention products derived from such processes. (blogspot.com)
The processes of freezing a formulation, followed by sublimation of the solvent to produce a lyo-cake, is extremely complicated, and demands further investigation of formulation design, stability, cycle development, and process scale-up to produce the highest quality lyo-product. (europeanpharmaceuticalreview.com)
BS EN ISO 11138-5:2006 provides specific requirements for test organisms, suspensions, inoculated carriers, biological indicators and test methods intended for use in assessing the performance of sterilization processes employing low-temperature steam and formaldehyde as the sterilizing agent. (bsigroup.com)
This project will research a treatment concept for the removal of PPPs that is new to greenhouse horticulture and which is based on two processes: biological treatment and adsorption. (kwrwater.nl)
The project's researchers will focus on the applicability in horticulture of physical/chemical and biological processes from water technology. (kwrwater.nl)

Both the FDA's Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER) have regulatory responsibility for therapeutic biological products, including premarket review and oversight. (fda.gov)
Please refer to the Transfer of Therapeutic Biological Products to the Center for Drug Evaluation and Research for updates that further define the categories of biological products that are regulated by CDER and CBER. (fda.gov)
For information concerning human drug products: Audrey A. Thomas, Center for Drug Evaluation and Research (HFD-7), Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, 301-594-5625. (fda.gov)
For information concerning human biological products: Valerie A. Butler, Center for Biologics Evaluation and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852-1448, 301-594-3074. (fda.gov)
The US Food and Drug Administration's (FDA) Center for Biologics Research and Evaluation (CBER) on Wednesday released its annual summary of manufacturing deviations reported by biologics, blood and blood component, and human cells, tissues, and cellular and tissue-based products (HCT/P) manufacturers. (raps.org)
Guidelines on Evaluation of Similar Biotherapeutic Products (SBPs). (who.int)

This statistic shows the direct export value of biological products from Taiwan between 2008 and 2017. (statista.com)
In 2017, the direct export value of biological products from Taiwan had amounted to approximately 598.29 million New Taiwan dollars. (statista.com)
At the end of June the EPO published a notice (see here ) stating from 1 July 2017 plants and animals exclusively obtained by means of an essentially biological process will no longer be patentable. (blogspot.com)
Albany, NY -- ( SBWIRE ) -- 06/12/2017 -- Biological products or biologics are therapeutic preparations that consist of natural complex biomolecules derived from living things. (sbwire.com)

The agency also says it saw an increase in the number of reporting establishments from 1,907 in FY2015 to 1,950 in FY2016, including three more allergenic product manufacturers, five more blood derivative manufacturers and five more in vitro diagnostic (IVD) manufacturers. (raps.org)
Based on end-user, the biological product manufacturing market has been segmented into hospitals, research and academic institutes, clinics and specialty trials, diagnostic labs, and others. (sbwire.com)
Rising incidence of chronic diseases across the world, availability of better diagnostic facilities, advances in the drug discovery and pharmaceutical R&D sector, and rising government initiatives are some of the factors attributed to the high growth of the biological product manufacturing market. (sbwire.com)
Lampire sells human and animal blood antibodies and related products, including serum and plasma, that are used in diagnostic testing by some of the world's leading pharmaceutical and life science companies, Krug said. (lampire.com)
The product indicated as " Research reagents " in the column Intended Use cannot be used for diagnostic nor any medical purpose. (ibl-japan.co.jp)

For these HCT/Ps regulated as biological products, the FDA requires premarket review of safety and efficacy data before these cellular therapy products are introduced into commercial market. (aabb.org)

This book presents an updated discussion of the chemical composition and biological properties of the main bee products. (springer.com)
He has extensively studied the quality parameters of honey, especially that from monofloral origin, as well as the relationship between its chemical composition and biological properties. (springer.com)
Reaction rule-based models in combination with the chemical kinetics information will enable the prediction of transformation product evolution during ozonation. (rsc.org)
The Fulbright Program in Ukraine is pleased to invite you to a seminar "Total Synthesis of Natural Products as a Driving Force for Chemical and Biological Discovery" by Fulbright Ph.D. student 2011-2016 Nataliia Shymanska , to be held on Tuesday, December 1, 2015, 6:00 p.m. , at the Fulbright Office (20 Esplanadna Street, Suite 904, M "Palats Sportu", Kyiv). (org.ua)
We are professional manufacture and develope of high quality and standard hot products, standard extract, plant extract by rate, herb database, chemical product, health products etc. (locateindia.com)
Recycling of Almond By-Products for Intestinal Inflammation: Improvement of Physical-Chemical, Technological and Biological Characteristics of a Dried Almond Skins Extract. (nutfruit.org)

The Commission reviewed the context and provisions of the Biotech Directive and published a notice on 3 November 2016 ( Notice 2016/C 411/03 ) concluding that the European Union legislators' intention when adopting the Biotech Directive was to exclude such products from patentability. (blogspot.com)
In the May 4, 2016, Federal Register , FDA issued both a proposed and direct final rule amending the general biological products standards relating to dating periods and removing certain standards relating to standard preparations and limits of potency. (mondaq.com)

In addition, the fermentation products wine and vinegar showed a similar nutritional composition that were present at a higher concentration than in juice, which indicated that fermentation helps in the dissolution of nutrient substances, while the thermal processing products dried slices and jam showed a similar nutritional composition. (rsc.org)
And Gold Millet has advanced biological fermentation producing equipment, first-class testing method, modernized scientific management and high quality employees. (indiabizclub.com)

The Healthcare Reform Law does not require FDA to issue a guidance document to articulate the policies for each product class, and the nonissuance of guidance does not preclude approval of a biosimilar. (morganlewis.com)
The Healthcare Reform Law gives FDA discretion in deciding whether to approve a product, except for any recombinant protein, through the biosimilar framework if "science and experience" do not allow such approval. (morganlewis.com)
[5] Importantly, FDA may indicate in a guidance document that the "science and experience" for a product or product class does not allow approval through the biosimilar framework. (morganlewis.com)
3) The term 'biosimilar biological product' means a specific strength of a biological product in final dosage form for which a biosimilar biological product application has been approved. (house.gov)
5) The term 'biosimilar biological product development meeting' means any meeting, other than a biosimilar initial advisory meeting, regarding the content of a development program, including a proposed design for, or data from, a study intended to support a biosimilar biological product application. (house.gov)
6) The term 'biosimilar biological product development program' means the program under this subpart for expediting the process for the review of submissions in connection with biosimilar biological product development. (house.gov)
ii) at which one or more biosimilar biological products are manufactured in final dosage form. (house.gov)
D) collecting fees under section 379j-52 of this title and accounting for resources allocated for the review of submissions in connection with biosimilar biological product development, biosimilar biological product applications, and supplements. (house.gov)
10) The term 'final dosage form' means, with respect to a biosimilar biological product, a finished dosage form which is approved for administration to a patient without substantial further manufacturing (such as lyophilized products before reconstitution). (house.gov)
A variety of terms, such as "biosimilar products", "follow-on protein products" and "subsequent-entry biologics" have been coined by different jurisdictions to describe these products. (who.int)

Biological products, like other drugs, are used for the treatment, prevention or cure of disease in humans. (fda.gov)
In contrast to chemically synthesized small molecular weight drugs, which have a well-defined structure and can be thoroughly characterized, biological products are generally derived from living material--human, animal, or microorganism-- are complex in structure, and thus are usually not fully characterized. (fda.gov)
Biological products subject to the PHS Act also meet the definition of drugs under the Federal Food, Drug and Cosmetic Act (FDC Act) . (fda.gov)
Note that hormones such as insulin, glucagon, and human growth hormone are regulated as drugs under the FDC Act , not biological products under the PHS Act . (fda.gov)
Following initial laboratory and animal testing that show that investigational use in humans is reasonably safe, biological products (like other drugs), can be studied in clinical trials in humans under an investigational new drug application (IND) in accordance with the regulations at 21 CFR 312. (fda.gov)
Several categories of drugs are identical to or derived from biological products. (amamanualofstyle.com)
The emergence of biological drugs has led to an increase in lyophilised drug products in the market. (europeanpharmaceuticalreview.com)
On 3 April 2012, the Brazilian government decided in Decree no. 7.713 to apply a margin of preference of 8% to 25% for the public procurement of nationally produced pharmaceutical drugs and biological medical products. (globaltradealert.org)

The National Institute of Biological Sciences (NIBS), Beijing, recently became the owners of the 100th Opera® High Content Screening System to be installed across the globe. (perkinelmer.com)
Thank you for your interest in spreading the word on Proceedings of the Royal Society of London B: Biological Sciences. (royalsocietypublishing.org)
Message Body (Your Name) thought you would like to see the Proceedings of the Royal Society of London B: Biological Sciences web site. (royalsocietypublishing.org)

In addition to the hypoxia (HIF1a) pathway products, SwitchGear offers the following reporter assay profiling sets in both plate format and biomarker subsets: CREB, NF-kB, heat shock (HSF), p53, STAT, serum response factor (SRF), and cholesterol biosynthesis (SREBP). (mtbeurope.info)
We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products. (cdc.gov)
Theiler's disease has been described in horses in many areas of the world after treatment with a variety of equine serum products, including tetanus antitoxin ( 3 - 8 ), botulinum antitoxin ( 9 ), antiserum against Streptococcus equi ( 4 , 10 ), pregnant mare's serum ( 4 ), and equine plasma ( 1 , 2 , 5 , 11 ). (cdc.gov)

These frequently asked questions have been developed for the CDER Small Business and Industry Assistance Web site to help small pharmaceutical businesses understand the regulatory process for therapeutic biological products. (fda.gov)
In terms of product type, the market is classified into bio-pharmaceutical products and biotechnological/biological products. (sbwire.com)

These products rely, in part, for their licensing on prior information regarding safety and efficacy obtained with the originator products. (who.int)
The intention of this document is to provide globally acceptable principles for licensing biotherapeutic products that are claimed to be similar to biotherapeutic products of assured quality, safety, and efficacy that have been licensed based on a full licensing dossier. (who.int)

Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. (ucsd.edu)

What Center has the regulatory responsibility for therapeutic biological products? (fda.gov)
This category includes therapeutic proteins derived from plants, animals, humans, or microorganisms, and recombinant versions of these products. (fda.gov)
As previously noted, some therapeutic protein products are approved under section 505 of the FDC Act, not under the PHS Act. (fda.gov)
The demonstration of bioequivalence of the generic medicine with a reference product is usually appropriate and sufficient to infer therapeutic equivalence between the generic medicine and the reference product. (who.int)
However, competitive costs of therapeutic products, requirement of highly skilled labor for high value low volume biological product manufacturing, limited availability foreign capital, and stringent regulatory affairs regarding the manufacture of biological products are restraining the global biological product manufacturing market. (sbwire.com)

The development and manufacture of biopharma products is set to be one of the fastest growing sections of the industry. (nsf.org)
It also discusses the use of the activity unit to define a quality attribute during product manufacture and control. (europa.eu)

Roberto Gambari, "Predictive Analyses of Biological Effects of Natural Products: From Plant Extracts to Biomolecular Laboratory and Computer Modeling," Evidence-Based Complementary and Alternative Medicine , vol. 2011, Article ID 383290, 4 pages, 2011. (hindawi.com)
Win big with SelectScience by sharing your opinion on laboratory products! (selectscience.net)
Our products are for laboratory research use only: Not for administration to humans! (biomol.com)

Digest™ contains extremely high counts of dozens of different strains of naturally occurring, beneficial microorganisms that significantly speed up the biological breakdown of cellulose and lignin. (farm-equipment.com)

There is a guidance document for biological products, including samples, to help you meet the IHS requirements. (mpi.govt.nz)

Biological Insecticide, 32 Oz Concentrate, Omri from Sears. (westfield.com)

BioTek Field Applications Scientists (FAS) and Product Specialists provide unparalleled scientific support, assisting with experimental planning and assay optimization on BioTek's instrumentation and software. (biotek.com)
Research indicates this product presents better Igg1 isotype blocking, reducing false positive assay results. (lampire.com)

Review the statutory definitions of a biological product as well as distinctions that drive jurisdiction and regulatory pathway. (fdli.org)

We recently initiated a Phase 1/2a study of this promising product in solid tumors, as both monotherapy and in combination with checkpoint inhibitors, and we anticipate initial top-line results from this important study by the end of 2020. (pharmiweb.com)

From bacteria to plants, biological agents pose serious risks to the preservation of cultural heritage. (nhbs.com)

When combined with Stormdry Masonry Protection Cream , Safeguard's biocidal solution can protect walls from both damp and biological growth. (buildingtalk.com)
Safeguard's SoluGuard Multi-Surface Biocide is a biocidal solution, which has been designed to remove biological growth and tackle moss and algae. (buildingtalk.com)
Once the combined system has been applied, the wall will be protected from both damp and biological growth. (buildingtalk.com)
Increasing focus on discovery of heat labile or temperature sensitive products, advanced biopharmaceutical research in medicine, and invention of effective means to treat various diseases are expected to boost the growth of the biological product manufacturing market. (sbwire.com)
Coping with Biological Grown on Stone Heritage Objects provides many case studies of removal of biological growth with practical advice for making the right choices. (nhbs.com)
Results on new substances with antimicrobic properties and alternative methods for the control of biological growth are presented as well. (nhbs.com)
Coping with Biological Grown on Stone Heritage Objects also emphasize issues on bioreceptivity of stones and the factors influencing biological growth and includes an outline of the various organisms able to develop on stones, a discussion on the bioprotection of stones by biofilms and lichens, a review of the main analytical techniques, and a section on bioremediation. (nhbs.com)
However, stringent regulatory framework and the requirement of skilled personnel for the effective use of biosurgery products may challenge market growth to a certain extent in the coming years. (marketresearch.com)
The growth of this segment can be attributed to a large number of commercially available sealants and their higher utilization (as compared to other biosurgery products) by surgeons in various surgeries. (marketresearch.com)
The report analyzes the biosurgery market and aims at estimating the market size and future growth potential of this market based on various segments such as product, application, and region. (marketresearch.com)

The biological activities of transformation products have been assessed by an effect-driven approach using in vitro bioassays. (rsc.org)

In addition, the report figures out the structure and concentration ratio of the current biological & biochemical products market in China by means of Bain's Market Structure Classification and Index of CR4. (marketpublishers.com)
This classification as a biological product is very significant, since it provides us with additional valuable exclusivity and confirms the FDA's acceptance of AGI-134's main mechanism of action as a vaccine," said Philip Serlin, Chief Executive Officer of BioLineRx. (pharmiweb.com)

SwitchGear Genomics, Inc., a provider of products for studying regulatory elements in the human genome, has launched cost-effective, high-throughput research tools for screening transcriptional activation and repression in a number of key biological pathways. (mtbeurope.info)
The new SwitchGear pathway sets utilize experimentally-validated luciferase reporter vectors to accurately quantify human promoter activity from complete sets of genes associated with inflammation, cholesterol biosynthesis, oncology, vascular biology, nuclear hormone receptor signalling, and many other important biological pathways. (mtbeurope.info)

A brief overview of the phases of the regulatory development pathway for HCT/Ps regulated as biological products is shown below. (aabb.org)

Shandong Microwave Machinery Co.,Ltd. offers a full range of Microwave thawing machine for microwave thawing applicationsDryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing. (epier.com)
Shandong Microwave Machinery Co.,Ltd. can supply products Microwave thawing machinefor operation at 915 MHz in a variety of Dryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing configurations. (epier.com)
Shandong Microwave Machinery Co.,Ltd. can also provide Dryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing for applications where the magnetron needs to be separate from the power supply and controls. (epier.com)
Shandong Microwave Machinery Co.,Ltd.is a Microwave thawing machine factory specializing in the production of Dryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing, scientific research,manufacturing,installation, commissioning.Shandong Microwave Machinery Co.,Ltd.can provide Microwave thawing machinecustomers with design and services of 1-2000 tons Dryer Vacuum Microwave products biological temperature Microwave Microwave Low thawing. (epier.com)

Once adequate nonclinical safety data has been collected, the sponsor may submit an Investigational New Drug (IND) application to study the effects of the biological product in humans. (aabb.org)
If the data generated by the studies demonstrate that the product is safe and effective for its intended use, the data are submitted as part of a marketing application. (fda.gov)
The Healthcare Reform Law provides only for one reference product per application. (morganlewis.com)
If you're applying to include a product catalogue or product list, you'll need to mention this in your permit application. (mpi.govt.nz)
A copy of the product catalogue, or product list, and a declaration of potential risk goods should be sent with the application. (mpi.govt.nz)
The global biological product manufacturing market has been segmented based on product type, end-user, application, and region. (sbwire.com)
BioTek's application notes present the latest-breaking scientific content covering the vast range of applications across our entire product line. (biotek.com)
Browse applications by topic, detection and product or use the simple keyword search to find the application notes that will facilitate your research. (biotek.com)
Our webinar archives are available for on-demand viewing - search to find a topic, application or product of interest. (biotek.com)
The report analyzes this market by product, application, and region. (marketresearch.com)

The biopharmaceuticals products segment accounted for the largest share of the global biological product manufacturing market. (sbwire.com)

A2085 was therefore selected as an active ingredient for biocontrol products and deposited under provisions of the Budapest Treaty in the Belgian Co-Ordinated Collections of Micro-Organisms (BCCM/MUCL) collection (accession MUCL54911). (mdpi.com)
Biological pigments, also known simply as pigments or biochromes, are substances produced by living organisms that have a color resulting from selective color absorption. (wikipedia.org)

The biotechnological/biological products segment includes micro-organism or eukaryotic cell culture, recombinant DNA technology products, gene therapy product, and cell therapy product. (sbwire.com)

For example, if there is no licensed pediatric strength and/or dosage form for the product defined and licensed, it must be diluted for use in pediatric patients. (gmp-compliance.org)
Upon receipt of a patient-specific prescription, a licensed pharmacy removing from one container the quantity of solid oral dosage form biological products necessary to fill the prescription and placing it in a smaller container to dispense directly to its customer. (gmp-compliance.org)

In recent years, marine natural products have gained attention from scientists within diverse research fields, such as biology, pharmacology, medicine and chemistry. (uio.no)

This ELISA kit can be used for measuring intact proinsulin, not including cleaved intermediate products, in mouse and rat samples. (ibl-japan.co.jp)

FDA also says it saw an uptick in the number of reports related to CBER-licensed IVDs, mostly related to unexpected reactions in testing, leaking vials or containers and products being received upside-down or on their side inside their shipping container. (raps.org)

Search by Keyword, Part #, Product or Accessory Type. (biotek.com)
Browse or search the topics or products of interest. (biotek.com)
Search the more than 3,000 scientific citations for BioTek's products within our database to learn more about the applications for our life science instrumentation as they're used around the world. (biotek.com)

Issuance of a biologics license is a determination that the product, the manufacturing process, and the manufacturing facilities meet applicable requirements to ensure the continued safety, purity and potency of the product. (fda.gov)
There are no clinically meaningful differences between the biological product and the reference product in terms of the safety, purity, and potency of the product. (morganlewis.com)

But they manifest in ways that make products simply easier for us as emotional irrational humans to love (or at least makes it easier to occasionally forgive them). (uxmag.com)
The biological half-life of caesium in humans is between one and four months. (wikipedia.org)

For some substances, it is important to think of the human or animal body as being made up of several parts, each with their own affinity for the substance, and each part with a different biological half-life (physiologically-based pharmacokinetic modelling). (wikipedia.org)

This designation provides the Company with eligibility to obtain 12 years of market exclusivity upon approval of the product for commercial use by the FDA. (pharmiweb.com)

Aristotle's Revenge: The Metaphysical Foundations of Physical and Biological Science / Edition 1 by Edward Feser |... (barnesandnoble.com)

Monkeys edge ecology and management long tailed macaques and their interface humans | Biological anthropology and primatology |... (cambridge.org)

Lifegard Aquatics TRIO Kit 1022 GPH Pond Filter with Quiet Pump with Mechanical and Biological Filtration R440023 - The Home... (homedepot.com)

Development Studies: Environment & the Developing World - Routledge (routledge.com)

Arteries and Arterial Blood Flow: Biological and Physiological Aspects: C. M. Rodkiewicz: : 9780387816357: Powell's Books (powells.com)

First in Fly - Stephanie Elizabeth Mohr | Harvard University Press (hup.harvard.edu)

Regulatory Strategy and Submissions - NSF International (nsf.org)

Microbiology | Book | English | Springer (springer.com)

Persil Powercaps Biological Washing Capsules 38 Wash 1.026Kg - Tesco Groceries (tesco.com)

Analysis of Free Radicals in Biological Systems | SpringerLink (link.springer.com)

Fertility Farming
- Acres USA — Fertility Farming - Acres USA (acresusa.com)

Talking Chicken by Kelly Klober
- Acres USA — Talking Chicken by Kelly Klober - Acres USA (acresusa.com)

Chemistry Archives - Page 10 of 43 - Nova Science Publishers (novapublishers.com)

2-(DIETHYLAMINO)-ETHYL ACRYLATE By Hebei Supai Biological Technology Co., Ltd., China (tradekey.com)

A biological profile for diagnosis and outcome of COVID-19 patients (degruyter.com)

Organisms4

Diseases2

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes2

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture6

Information Science7

Named Groups1

Health Care13

Geographicals1

Changes of neonatal mortality rate between 'pre' and 'post' surfactant period. (1/1706)

Surfactant treatment for acute respiratory distress syndrome. (2/1706)

Preclinical development strategies for novel gene therapeutic products. (3/1706)

Regulatory decision strategy for entry of a novel biological therapeutic with a clinically unmonitorable toxicity into clinical trials: pre-IND meetings and a case example. (4/1706)

Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond. (5/1706)

Are there environmental forms of systemic autoimmune diseases? (6/1706)

The role of the toxicologic pathologist in the preclinical safety evaluation of biotechnology-derived pharmaceuticals. (7/1706)

Structures of surfactant films: a scanning force microscopy study. (8/1706)

Biotechnology

Consumer Product Safety

N-Ethylmaleimide-Sensitive Proteins

Cyclic GMP

Medical Audit

Water

Libraries, Medical

Pest Control

Pest Control, Biological

Insect Control

Organic Agriculture

Agrochemicals

Bedbugs

Insecticides

Patents as Topic

Computers

Software

Inventions

Autoanalysis

Intellectual Property

Computer Simulation

Oenothera

Medical Secretaries

Methoprene

Biological Products

Cestode Infections

Cestoda

Viola

Substance P

Practice Guidelines as Topic

Biosimilar Pharmaceuticals

Terminology as Topic

Legislation, Drug

Pharmaceutic Aids

Sterilization

Erythema Nodosum

Sterilization, Tubal

Sterilization, Reproductive

Leprosy, Lepromatous

Sterilization Reversal

Elastin

Thrombin

Foramen Ovale, Patent

Search Engine

Acetals

Stereoisomerism

Leukocyte Reduction Procedures

Boranes

Molecular Structure

Cyclization

Changes of neonatal mortality rate between 'pre' and 'post' surfactant period. (1/1706)

Surfactant treatment for acute respiratory distress syndrome. (2/1706)

Preclinical development strategies for novel gene therapeutic products. (3/1706)

Regulatory decision strategy for entry of a novel biological therapeutic with a clinically unmonitorable toxicity into clinical trials: pre-IND meetings and a case example. (4/1706)

Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond. (5/1706)

Are there environmental forms of systemic autoimmune diseases? (6/1706)

The role of the toxicologic pathologist in the preclinical safety evaluation of biotechnology-derived pharmaceuticals. (7/1706)

Structures of surfactant films: a scanning force microscopy study. (8/1706)

China Red Yeast Rice Extract / Red Yeast Rice / Red Rice Yeast - China Red Yeast Rice Extract, Red Yeast Rice Powder

Natural products - Drug discovery and therapeutic medicine - Zh Torrent Download - LimeTorrents

Solaray - Red Yeast Rice 600 mg 120 Capsules - Save 45%

Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents |...

Merck Donates Natural Products Library For Research - Intellectual Property Watch

Natural Product Chemistry for Drug Discovery: RSC (RSC Biomolecular Sciences) direct download | bukmekerskajakontora.ru

Red Yeast Rice Supplements for High Cholesterol | Prevention

Colon Cancer and Red Yeast Rice - Article Preview

Red Yeast Rice Extract - Red Yeast Rice Extract Suppliers, Buyers, Wholesalers and Manufacturers - ecplaza.net

Red Yeast Rice Extract | Article about Red Yeast Rice Extract by The Free Dictionary

Expert discusses natural products chemistry and anticancer drug discovery | WMU News | Western Michigan University

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

The Study Botanical: Coenzyme Q-10 and Red Yeast Rice

Harnessing the Chemistry of Plant Natural Product Biosynthesis | Duke Chemistry

Red Yeast Rice With Co Q 10 - List Owel Food Fair

Kal Red Yeast Rice - KAL - Red Yeast Rice Once Daily 1200mg - 30ct Tab

Buy Protocol for Life Balance Red Yeast Rice Extract - 600 mg - 90 VCapsules - eVitamins Australia

KAL - Red Yeast Rice, CoQ10, Omega 3 600/30/500mg - 60ct Sg

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products - Natural Product Reports ...

Metabolites | Free Full-Text | A Historical Overview of Natural Products in Drug Discovery

Marine Drugs | Free Full-Text | Natural Product Research in the Australian Marine Invertebrate Dicathais orbita

RFA-RM-09-005: New Methodologies for Natural Products Chemistry (R01)