Biological Phenomena: Biological processes, properties, and characteristics of the whole organism in human, animal, microorganisms, and plants, and of the biosphere.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Biological Assay: A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.Biological Therapy: Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Biological Warfare: Warfare involving the use of living organisms or their products as disease etiologic agents against people, animals, or plants.Time Factors: Elements of limited time intervals, contributing to particular results or situations.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.Immunologic Memory: The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.Memory, Short-Term: Remembrance of information for a few seconds to hours.Quantum Dots: Nanometer sized fragments of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY TECHNIQUES.Pancreas, Artificial: Devices for simulating the activity of the pancreas. They can be either electromechanical, consisting of a glucose sensor, computer, and insulin pump or bioartificial, consisting of isolated islets of Langerhans in an artificial membrane.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Insulin Infusion Systems: Portable or implantable devices for infusion of insulin. Includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor.Diagnostic Equipment: Nonexpendable items used in examination.Planets: Celestial bodies orbiting around the sun or other stars.Hafnia alvei: The type species for the genus HAFNIA. It is distinguished from other biochemically similar bacteria by its lack of acid production on media containing sucrose. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Elements: Substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.Earth (Planet): Planet that is the third in order from the sun. It is one of the four inner or terrestrial planets of the SOLAR SYSTEM.Environment: The external elements and conditions which surround, influence, and affect the life and development of an organism or population.

The molluscicidal activity of the latex of Euphorbia splendens var. hislopii on Melanoides tuberculata (Thiaridae), a snail associated with habitats of Biomphalaria glabrata (Planorbidae). (1/15)

The use of the latex of Euphorbia splendens var. hislopii was considered as an effective control method for Biomphalaria glabrata in Sumidouro, Rio de Janeiro. However, the appearance and expansion of the snail Melanoides tuberculata since August 1997, with the concomitant reduction of the population of B. glabrata suggest that competitive exclusion might be taking place. Depending on the susceptibility of the thiarid to the E. splendens toxin, the natural control that is occurring could be interrupted by the employment of the latex if the planorbid were less susceptible to the toxin. The aim of this study is to investigate the molluscicidal activity of the latex on M. tuberculata. We used 420 M. tuberculata, from Sumidouro. Fourteen different latex concentrations were tested using World Health Organization general methodology. Probit analysis was used for LD90 and LD50 determination. The LD50 was 3.57 mg/l and LD90 was 6.22 mg/l. At the highest concentration (10 mg/l) there was no survival. No significant differences among replicas (chi2 = 8.31; gl = 13; p > 0.05) were found. The LD90 dose for M. tuberculata was 13.8 times greater than that for B. glabrata, so that the molluscicide in the presence of the thiarid may have a synergic effect on reduction of Biomphalaria populations.  (+info)

Coevolutionary networks: a novel approach to understanding the relationships of humans with the infectious agents. (2/15)

Human organism is interpenetrated by the world of microorganisms, from the conception until the death. This interpenetration involves different levels of interactions between the partners including trophic exchanges, bi-directional cell signaling and gene activation, besides genetic and epigenetic phenomena, and tends towards mutual adaptation and coevolution. Since these processes are critical for the survival of individuals and species, they rely on the existence of a complex organization of adaptive systems aiming at two apparently conflicting purposes: the maintenance of the internal coherence of each partner, and a mutually advantageous coexistence and progressive adaptation between them. Humans possess three adaptive systems: the nervous, the endocrine and the immune system, each internally organized into subsystems functionally connected by intraconnections, to maintain the internal coherence of the system. The three adaptive systems aim at the maintenance of the internal coherence of the organism and are functionally linked by interconnections, in such way that what happens to one is immediately sensed by the others. The different communities of infectious agents that live within the organism are also organized into functional networks. The members of each community are linked by intraconnections, represented by the mutual trophic, metabolic and other influences, while the different infectious communities affect each other through interconnections. Furthermore, by means of its adaptive systems, the organism influences and is influenced by the microbial communities through the existence of transconnections. It is proposed that these highly complex and dynamic networks, involving gene exchange and epigenetic phenomena, represent major coevolutionary forces for humans and microorganisms.  (+info)

Dewetting and hydrophobic interaction in physical and biological systems. (3/15)

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The challenge of lipid rafts. (4/15)

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Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease. (5/15)

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Kinetic modeling of biological systems. (6/15)

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The cattle genome reveals its secrets. (7/15)

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Exploratory research on bioactive natural products with a focus on biological phenomena. (8/15)

The discovery of new basic compounds holds the key for advancing material sciences. We have focused on the identification and characterization of natural key compounds that control biologically and physiologically intriguing phenomena. The discovery of new bioactive molecules, facilitated by a deeper understanding of nature, should advance our knowledge of biological processes and lead to new strategies to treat disease. The structure and function of natural compounds are sometimes unexpectedly original. Based on our past experience and results, we have carried out research to find new directions for compound exploration by directly learning from dynamic biological phenomena in the field, and have succeeded in creating a new research field in biological molecular sciences.  (+info)

*Female sperm storage

The internal phenomena of reproduction in Drosophila. Biological Bulletin. 1920; 39(4):207-230. Omura S. Structure and function ... Biological Reviews. 63:509-549. Den Boer SPA, Baer B, Dreier S, Aron S, Nash DR, Boomsma JJ. 2009. Prudent sperm use by leaf- ... Biological Journal of the Linnean Society. 50:295-311. Holt W. 2011. Mechanisms of sperm storage in the female reproductive ... Female sperm storage is a biological process and often a type of sexual selection in which sperm cells transferred to a female ...

*DNA computing

In March 2013, researchers created a transcriptor (a biological transistor).[11] In August 2016, researchers used the CRISPR ... Nonlinear Phenomena. 237 (9): 1165-1172. Bibcode:2008PhyD..237.1165K. doi:10.1016/j.physd.2008.01.027.. . Also available here: ... Kahan, M.; Gil, B.; Adar, R.; Shapiro, E. (2008). "Towards molecular computers that operate in a biological environment". ...

*Symbiosis

This article is about the biological phenomenon. For other uses, see Symbiosis (disambiguation). ... is any type of a close and long-term biological interaction between two different biological organisms, be it mutualistic, ... Vane-Wright, R. I. (1976). "A unified classification of mimetic resemblances". Biological Journal of the Linnean Society. 8: 25 ... Muller's ratchet phenomenon together with less effective population sizes leads to an accretion of deleterious mutations in the ...

*Protein

Lectins typically play a role in biological recognition phenomena involving cells and proteins.[35] Receptors and hormones are ... Journal of Biological Chemistry. 69 (2): 435-41.. *^ Pauling L, Corey RB, Branson HR (1951). "The structure of proteins: two ... Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and ... Protein is generally used to refer to the complete biological molecule in a stable conformation, whereas peptide is generally ...

*Protein

Lectins typically play a role in biological recognition phenomena involving cells and proteins.[39] Receptors and hormones are ... Journal of Biological Chemistry. 69 (2): 435-41.. *^ Pauling L, Corey RB (May 1951). "Atomic coordinates and structure factors ... Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and ... Protein is generally used to refer to the complete biological molecule in a stable conformation, whereas peptide is generally ...

*Protein

Lectins typically play a role in biological recognition phenomena involving cells and proteins.[39] Receptors and hormones are ... Journal of Biological Chemistry. 69 (2): 435-41.. *^ Pauling L, Corey RB (May 1951). "Atomic coordinates and structure factors ... Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and ... Protein is generally used to refer to the complete biological molecule in a stable conformation, whereas peptide is generally ...

*CFD-ACE+

These equations enable coupled simulations of fluid, thermal, chemical, biological, electrical and mechanical phenomena.[1] ... CFD-ACE+ was used by the Indian Institute of Technology Bombay to model the interplay of multiphysics phenomena involved in ...

*Emergence

Emergent structures can be found in many natural phenomena, from the physical to the biological domain. For example, the shape ... For instance, the phenomenon of life as studied in biology is an emergent property of chemistry, and psychological phenomena ... In other words, emergence itself... has been the underlying cause of the evolution of emergent phenomena in biological ... Epiphenomenon - Secondary phenomenon that occurs alongside or in parallel to a primary phenomenon ...

*Hans Driesch

Driesch, H. (1924). The Biological Setting of Psychical Phenomena. The Quest 15 (July): 433-456. Driesch, H. (1925). The Crisis ... From 1891 Driesch worked in Naples at the Marine Biological Station, where until 1901 he continued to experiment and seek a ... He became interested in parapsychology and published on such phenomena as telepathy, clairvoyance, and telekinesis. His concept ...

*Stage hypnosis

Braid's quote is at p.512 of Braid, J., "Electro-Biological Phenomena Physiologically and Psychologically Considered, by James ... Ormond McGill, The New Encyclopedia of Stage Hypnosis, 1996: 24 Braid, J. (1851). Electro-Biological Phenomena, etc., p.530. ... phenomena; he never used it to treat anyone at any time (in public or private). Braid always maintained that he had gone to ... phenomena created by stage hypnotists is easily done without hypnosis. However the photos of his examples always show support ...

*Hebbian theory

Klopf's model reproduces a great many biological phenomena, and is also simple to implement. ... A variation of Hebbian learning that takes into account phenomena such as blocking and many other neural learning phenomena is ... It also provides a biological basis for errorless learning methods for education and memory rehabilitation. In the study of ... "A computational study of the diffuse neighbourhoods in biological and artificial neural networks" (PDF). International Joint ...

*James Braid (surgeon)

Braid, Electro-Biological Phenomena, etc., p.530. M'Neile, H., "Satanic Agency and Mesmerism; A Sermon Preached at St Jude's ... Braid, J., "Electro-Biological Phenomena Physiologically and Psychologically Considered, by James Braid, M.R.C.S. Edinburgh, &c ... those phenomena]. [Braid] considered that the mental phenomena were only rendered possible by previous physical changes; and, ... Braid investigated the phenomenon of "table-turning" and clearly confirmed Michael Faraday's conclusion that the phenomenon was ...

*History of hypnosis

Braid, Electro-Biological Phenomena, etc., p.530. Braid, J. "Magic, Mesmerism, Hypnotism, etc., Historically and ... As he later wrote, Inasmuch as patients can throw themselves into the nervous sleep, and manifest all the usual phenomena of ... Hypnosis, which at the end of the 19th century had become a popular phenomenon, in particular due to Charcot's public hypnotism ... But my experiments have proved that the ordinary phenomena of mesmer- ism may be realised through the subjective or personal ...

*George Truskey

"Book Review: Transport Phenomena in Biological Systems" (PDF). Annals of Biomedical Engineering. Retrieved 14 March 2014. [ ... Truskey, George; Yuan F; Katz D (2009). Transport Phenomena in Biological Systems (Second ed.). Prentice Hall. p. 888. ISBN 978 ... George Alexander Truskey is an American biomedical engineer noted for his research on transport phenomena in biological systems ... a biomedical engineering textbook entitled Transport Phenomena in Biological Systems, over 6 book chapters, and over 180 ...

*Lévy flight

"Lévy flight random searches in biological phenomena". Physica A: Statistical Mechanics and its Applications. 314: 208-213. doi: ... Biological flight data can also apparently be mimicked by other models such as composite correlated random walks, which grow ... related to chaos theory and is useful in stochastic measurement and simulations for random or pseudo-random natural phenomena. ...

*Apoptosis

In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in a wide variety ... a basic biological phenomenon with wide-ranging implications in tissue kinetics". Br. J. Cancer. 26 (4): 239-57. doi:10.1038/ ... Journal of Biological Chemistry. 280 (49): 40985-40995. doi:10.1074/jbc.M502190200. PMID 16188880.. ... Following the publication of a paper describing the phenomenon, Kerr was invited to join Alastair R. Currie, as well as Andrew ...

*قلادة ملكية - ويكيبيديا، الموسوعة الحرة

"For his statistical inquiries into biological phenomena.". 1887. ألكسندر كلارك [الإنجليزية]. علم شكل الأرض ومساحتها. "For his ... "For his researches in the kinetic theory of gases, in terrestrial magnetism and in the phenomena of the upper atmosphere.". ... "In recognition of his distinguished studies of the biological activity of peptide hormones in relation to their structure.". ... "For his services to biological science and oceanography in connection with the "Challenger" reports, and for his original ...

*Boris Kholodenko

"Control analysis of periodic phenomena in biological systems". J. Phys. Chem. 101: 2070-2081. doi:10.1021/jp962336u. CS1 maint ...

*Creation science

"Evolution pervades all biological phenomena. To ignore that it occurred or to classify it as a form of dogma is to deprive the ... No other biological concept has been more extensively tested and more thoroughly corroborated than the evolutionary history of ... With federal grant funding, the Biological Sciences Curriculum Study (BSCS) drafted new standards for the public schools' ... Scientists also deem creation science's attacks against biological evolution to be without scientific merit. Those views of the ...

*Alpena Community College

It stresses mathematics and biological factors in psychological phenomena. It can provide a foundation for clinical psychology ...

*Reynolds number

3-11 (1977)[2] Truskey, G. A., Yuan, F, Katz, D. F. (2004). Transport Phenomena in Biological Systems Prentice Hall, pp. 7. ... What is the explanation for this phenomenon? A large Reynolds number indicates that viscous forces are not important at large ... Bird R.B., Stewart W.E., Lightfoot E.N. Transport phenomena Batchelor, G. K. (1967). An Introduction to Fluid Dynamics. ...

*Robert Arp

Arp, R. (2008). "Life and the homeostatic organization view of biological phenomena". Cosmos and History: The Journal of ... He calls this position the homeostatic organization view of biological phenomena. With Alexander Rosenberg, Arp has edited ... The Infectious Disease Ontology is one of the ontologies in the Open Biological and Biomedical Ontologies Foundry, also known ... emergent phenomena because of the way in which the components are organized to maintain homeostasis of the organism at the ...

*Glass ceiling

596 (62). Schulpen, Tom W.J. (September 2017). "The glass ceiling: A biological phenomenon". Medical Hypotheses. 106: 41-43. ... Thereby, this phenomenon is related to gender differentials at the bottom of the wage distribution. Building on the seminal ... Similar to the sticky floor, the frozen middle describes the phenomenon of women's progress up the corporate ladder slowing, if ... a parallel phenomenon called the "glass escalator" is occurring. This can be defined as how more men are joining fields that ...

*Computational neuroscience

... collaborate closely with experimentalists in analyzing novel data and synthesizing new models of biological phenomena. ... Biological neurons are connected to each other in a complex, recurrent fashion. These connections are, unlike most artificial ... Main article: Biological neuron models. Even single neurons have complex biophysical characteristics and can perform ... Hence there is a drive to produce simplified neuron models that can retain significant biological fidelity at a low ...

*Roger Masters

Ostracism: A Social and Biological Phenomenon. http://www.bepress.com/gruterclassics/ostracism (ISBN 0-317-55376-3). Masters, ... The Sense of Justice: Biological Foundations of Law. Newbury Park, CA: Sage Publications (ISBN 0-8039-4398-9). Masters, Roger D ... The central concern of his career has been how biological circumstances influence individual behavior and social outcomes. ... https://www.jstor.org/stable/2827464 Masters, Roger D. (1983), The Biological Nature of the State. World Politics, Vol. 35, No ...

*Piotr Lenartowicz

His main interests revolve around philosophy of biology including integration of biological phenomena, theory of the genetic ... Lenartowicz, P. Philosophy of Biological Phenomena (in Polish), WAM, Cracow, 1985. Lenartowicz, P. Theory of cognition (polish ... In his dissertation Phenotype-Genotype Dichotomy published in 1975, he described irreducibility of certain biological phenomena ... working on theory of biological phenomena, in 1986. In 1999 he became a full professor. Lenartowicz participated in seminars in ...

*Ariosa v. Sequenom

If a method of detecting a natural phenomenon is always "directed to" that natural phenomenon, as the Federal Circuit suggests ... especially in biological sciences, is undesirable. But he insisted that "any further guidance must come from the Supreme Court ... the claimed naturally occurring phenomenon into a patent-eligible application"of the phenomenon. ... 1) a researcher is the first to discover a natural phenomenon;. (2) that unique knowledge motivates him to apply a new ...

*پروتئین - ویکی‌پدیا، دانشنامهٔ آزاد

Lectins typically play a role in biological recognition phenomena involving cells and proteins.[35] Receptors and hormones are ... Journal of Biological Chemistry. 69 (2): 435-41.. *^ Pauling L, Corey RB (May 1951). "Atomic coordinates and structure factors ... Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and ... Protein is generally used to refer to the complete biological molecule in a stable conformation, whereas peptide is generally ...
Abstract: Recent years have witnessed extensive research activity in modeling biological phenomena as well as in developing intervention strategies for such phenomena. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of biological phenomena. In this paper, two different intervention strategies, namely direct and indirect, are proposed for the S-system model. In the indirect approach, the prespecified desired values for the target variables are used to compute the reference values for the control inputs, and two control algorithms, namely simple sampled-data control and model predictive control (MPC), are developed for transferring the control variables from their initial values to the computed reference ones. In the direct approach, a MPC algorithm is developed that directly guides the target variables to their desired values. The proposed intervention strategies are applied to the ...
EONS modeling platform is a resourceful learning and research tool to study the mechanisms underlying the non-linear dynamics of synaptic transmission with the aid of mathematical models. Mathematical modeling of information processing in CNS pathways, in particular modeling of molecular events and synaptic dynamics, have not been extensively developed owing to the complex computations involved in integrating a multitude of parameters. In this paper, we discuss the development of a strategy to adapt the EONS synaptic modeling platform to a multi-node environment using a parallel computational framework to compute data intensive long simulations in a shorter time frame. We describe how this strategy can be applied to (i) determine the optimal values of the numerous parameters required for fitting experimental data, (ii) determine the impact of all parameters on various aspects of synaptic transmission (under normal conditions or conditions mimicking pathological conditions) and (iii) study the ...
A sequence of measured quantities is determined for a chemical reactor and a data generator generates a curve in normal coordinates from a respective predetermined normal form that describes a type of critical state. Each normal form is imaged onto the sequence of measured quantities by neural networks whereby a respective neural network is allocated to a data generator. The imaging is optimized by applying parameter optimization methods. The neural network that converges best through use of parameter optimization method describes the critical state that lies closest to the actual state of the chemical reactor.
In object-based image analysis (OBIA), the appropriate parametrization of segmentation algorithms is crucial for obtaining satisfactory image classification results. One of the ways this can be done is by unsupervised segmentation parameter optimi...
Abstract. As one of the drinking water sources for Xuzhou city, Yuquan River has been polluted seriously in recent years. In this paper, enhanced coagulation t
The formation of filaments from naturally occurring protein molecules is a process at the core of a range of functional and aberrant biological phenomena, such as the assembly of the cytoskeleton or the appearance of aggregates in Alzheimers disease. The macroscopic behaviour associated with such processes
In order to study a complex biological phenomenon such as tumor cell metastasis, one must focus on examining discrete aspects of the process which are amenable to experimentation. In this thesis, I made use of xenograft ...
Aging process is a biological phenomenon, which everyone has to undergo at a certain point of life. It is accentuated by a few factors, details of which are explained in the article below.
012492543X: Biochemistry, 2 Vol. Set, Metzler D.E. - |p align=justify|Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Bioche
JC just returned from two back-to-back meetings in Snowmass, CO. He presented work on small-helix partitioning in membranes at the first meeting on Free Energy Methods and structures of BamA and a new complex between SecY and a nascent chain at the second meeting on Membrane Proteins. Not all the time was spent in front of a screen though, as the picture to the right clearly shows!. ...
Fit biologically meaningful distribution functions to time-sequence data (phenology), estimate parameters to draw the cumulative distribution function and probability density function and calculate standard statistical moments and percentiles.
The work presented has highlighted the many disadvantages of parameter optimisation. Whilst significant improvements in the r.m.s.e were achieved in some areas, this was only after extensive testing and regeneration of the same model. The large number of strategy parameters used in OrthoMAX means that to test every parameter combination would be an enormous undertaking and clearly impracticable in normal circumstances. The data and results from the study prove the extreme variability of the software in certain areas, and the importance and criticality of the strategy parameters. Whilst the parameters have proved to have a significant effect in certain areas, the data has shown that manipulation of the parameters has little if any effect in areas well suited to the matching algorithm. Improvements in the accuracy of these areas are likely to be marginal through manipulation of the strategy parameters. The tests in this study were all carried out on data with checkpoint information. If this data ...
Despite recent advances in the field of image-guided interventions (IGI), the bottleneck for Angiography/X-ray guided procedures in particular is accurate and robust 2D-3D image alignment. The conventional, straight-forward parameter optimisation approach is known to be ill-posed and less efficient. Retrieval-based approaches may be of superior choice here. However, this requires salient and robust image features, which can handle the difficulties of Angiographic images such as high level of noise and contrast variance. In this paper, we investigate state-of-the-art features of the field of computer vision regarding the applicability and reliability in the challenging scenario of Angiography ...
Polymeric thin films coated on non-wettable substrates undergo film-instabilities, which are usually manifested as surface deformation in the form of dewetting or wrinkling. The former takes place in fluidic films, whereas the latter occurs in solid films. Therefore, there have rarely been reports of systems
The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena.Papers should either provide biological insight as a ...
Cocoa is a dense annotator for biological text. It annotates macromolecules, chemicals, protein/DNA parts, organisms, processes, anatomical parts, locations, physiological terms, parameters, values, experimental techniques, and foods. It should be noted that Cocoas coverage of general biological phenomena (i.e. evolution) tends to be poor. Cocoa provides a RESTful API that returns information in JSON.
At the onset of our experiments with gemcitabine in pancreatic cancer cells, we were surprised to find that there was a large inconsistency in the published results (Fig. 1B and SI Appendix, Table S1). The same cell lines in different studies were reported as sensitive or resistant, and this was true in all 15 cell lines tested. We found that differences in sensitivity depended very strongly on the cell density (Fig. 1D), and this stands as the most likely explanation for these findings and perhaps for others in drug-profiling efforts (6). Discrepancy in experimental findings is often blamed on sloppiness and has been excoriated as part of an epidemic of irreproducible scientific experiments (51). A fairer lesson is that inconsistency may reflect the extreme sensitivity of some biological phenomena to experimental conditions. History has shown that trying to resolve these can inspire discovery, as we believe has happened here. The resolution to the discrepant findings with gemcitabine is in ...
Programmed cell death or apoptosis is a widespread biological phenomenon. Apoptosis is characterized by typical cell features such as membrane blebbing, chromatin condensation, and DNA fragmentation....
Calpain represents a family of Ca(2+)-dependent cytosolic cysteine proteases found in almost all eukaryotes and some bacteria, and is involved in a variety of biological phenomena, including brain function. Several substrates of calpain are aggressively proteolyzed under pathological conditions, e.g …
Malvern MicroCal microcalorimeters enable characterization of biomolecular interactions in solution measurements of binding affinity thermodynamics and stability.
!%Plexera LLC%! has launched the PlexArray HT system, a high-throughput, label-free, surface plasmon resonance-based biomolecular interaction detecti
Pterygium is a common ocular surface disease characterized by fibrovascular invasion of the cornea and is sight-threatening due to astigmatism, tear film disturbance, or occlusion of the visual axis. However, the mechanisms for formation and post-surgical recurrence of pterygium are not understood, and a valid animal model does not exist. Here, we investigated the possible mechanisms of pterygium pathogenesis and recurrence. First we performed a genome wide expression analysis (human Affymetrix Genechip, >22000 genes) with principal component analysis and clustering techniques, and validated expression of key molecules with PCR. The controls for this study were the un-involved conjunctival tissue of the same eye obtained during the surgical resection of the lesions. Interesting molecules were further investigated with immunohistochemistry, Western blots, and comparison with tear proteins from pterygium patients. Principal component analysis in pterygium indicated a signature of matrix-related structural
Just about everyone on this planet would dearly love to honor any research scientist who can find a cure for cancer. Despite all the money and time already poured into extensive research efforts in labs and hospitals, the goal of curing this devastating clinical disease still remains elusive; about 589,000 cancer patients are expected to die from cancer in 2015 [1]. A big question thus arises, "What good is all the research and money spent on trying to conquer cancer, if a cure still has not been found after all these years?" The more you know about cancer as a biological phenomenon, the better will you be able to understand why attaining a general cure is so very, very difficult. This brief essay will teach you about the reasons for this frustrating situation that seems to damn the efforts of dedicated researchers in both basic and clinical science.. A brief background of essentials about cancer. At its most fundamental level, the biological phenomenon of cancer takes place in our cells. All ...
Just about everyone on this planet would dearly love to honor any research scientist who can find a cure for cancer. Despite all the money and time already poured into extensive research efforts in labs and hospitals, the goal of curing this devastating clinical disease still remains elusive; about 589,000 cancer patients are expected to die from cancer in 2015 [1]. A big question thus arises, "What good is all the research and money spent on trying to conquer cancer, if a cure still has not been found after all these years?" The more you know about cancer as a biological phenomenon, the better will you be able to understand why attaining a general cure is so very, very difficult. This brief essay will teach you about the reasons for this frustrating situation that seems to damn the efforts of dedicated researchers in both basic and clinical science.. A brief background of essentials about cancer. At its most fundamental level, the biological phenomenon of cancer takes place in our cells. All ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Cad Dynamic Freeware - Free Software Listing (Page3). Companion Software for the Dynamic Modeling and Control of Engineering Systems, 2e book by J. This book starts with a review of parameter optimization and then treats dynamic optimization, first with fixed final time and no constraints, next with terminal contraints, and finally with terminal constraints and open final time.
CHANG Hung-Jen , FREEMAN Walter J. , BURKE Brian C. Neural networks : the official journal of the International Neural Network Society 11(3), 449-466, 1998-04-01 参考文献21件 被引用文献1件 ...
Recent advances in the use of plasmonic metamaterials to improve absorption of light in thin-film solar photovoltaic devices has created a demand for a scalable method of patterning large areas with metal nanostructures deposited in an ordered array. This article describes two methods of fabricating ordered 2D nanosphere colloidal films: spin coating and interface coating. The two methods are compared and parameter optimization discussed. The study reveals that: ...
Lipids are a different and ubiquitous cluster of compounds having key biological functions like structural constituents of cell membranes, aiding as energy storage bases and play a part in cell signaling pathways. Compound research in structural diversity of lipids benefits developments in the field of membrane lipids which in turn explains biological phenomena at the nanoscale sphere. Multiple roles can be performed by Phospholipids in cells by creating the permeability blockade for cells and cell organelles and by providing the matrix for the association and utility of a wide diversity of catalytic developments, also by substitute as donors in the production of macromolecules, and by keenly inducing the functional properties of membrane-associated developments.. ...
If you have a question about this talk, please contact Lorena Escudero.. Location matters in biology. Both the inner workings of tissues and organs and their dysregulation, which leads to disease, depend on the tight web of relationships between different cell populations, and on the concerted regulation of their function mediated by genetic and environmental effects. In the last 10 years and more, it has become clear that many biological phenomena cannot be studied by analyzing cells in bulk and outside of their natural environment, but their underlying mechanisms can only be mechanistically investigated if observed both at the single-cell level and in situ. While technologies allowing either the former or the latter of these features are now available, combining both is extremely challenging, at least with the throughput necessary to obtain reliable results. In our laboratory, we have recently launched a project, named IMAXT (Imaging and Molecular Annotation of Xenografts and Tumours), that ...
Location matters in biology. Both the inner workings of tissues and organs and their dysregulation, which leads to disease, depend on the tight web of relationships between different cell populations, and on the concerted regulation of their function mediated by genetic and environmental effects. In the last 10 years and more, it has become clear that many biological phenomena cannot be studied by analyzing cells in bulk and outside of their natural environment, but their underlying mechanisms can only be mechanistically investigated if observed both at the single-cell level and in situ. While technologies allowing either the former or the latter of these features are now available, combining both is extremely challenging, at least with the throughput necessary to obtain reliable results. In our laboratory, we have recently launched a project, named IMAXT (Imaging and Molecular Annotation of Xenografts and Tumours), that aims to produce a comprehensive tri-dimensional map of breast tumours in ...
Bioengineering applies engineering principles and methodologies to biological and medical sciences to better understand biological phenomena, to devel...
A STRESSFUL life in the womb is known to affect adult behaviour in both animals and humans. But stress is a complex biological phenomenon, so scientists have found it hard to pin down the mechanism for this link. Now a team of researchers in France says that the stress hormone corticosterone is to blame. They …
We use the tools of Structural Biology to investigate the key biomolecular interactions that underpin the molecular mechanisms of life and disease.. Read More ». ...
Mathematical Problems in Engineering is a peer-reviewed, Open Access journal that publishes results of rigorous engineering research carried out using mathematical tools. Contributions containing formulations or results related to applications are also encouraged. The primary aim of Mathematical Problems in Engineering is rapid publication and dissemination of important mathematical work which has relevance to engineering. All areas of engineering are within the scope of the journal. In particular, aerospace engineering, bioengineering, chemical engineering, computer engineering, electrical engineering, industrial engineering and manufacturing systems, and mechanical engineering are of interest. Mathematical work of interest includes, but is not limited to, ordinary and partial differential equations, stochastic processes, calculus of variations, and nonlinear analysis.
Most loaches will eat these snails. Whilst the Clown Loach is the most often quoted as doing this function it can grow quite large. If you want a smaller fish there are several species of loaches (like the Zebra Loach, Pakistan loach (Yo Yo)) that remain under 4" in length and will eat the snails when small. Puffers like the Ceylon Puffer will eat any type of snail once it grows bigger enough ...
In collaboration with the Theoretical and Computational Biophysics Group at the University of Illinois, we will be hosting a workshop on using computational techniques to simulate and analyze biological systems. The focus of the workshop is on the programs NAMD and VMD, developed by the TCB Group. The workshop will be from Nov. 3 - 7 on the Georgia Tech campus. More information can be found here: http://www.ks.uiuc.edu/Training/Workshop/Atlanta2014/. ...
Purpose : The development of stem cell-derived retinal organoid systems has opened previously unimaginable possibilities for the study and potential treatment of retinal degenerative diseases. However their variability and the lack of high throughput platforms for their analysis pose severe limitations for their use in drug development applications. Hence, the purpose of this work was to develop a platform (3D- ARQ) that enables fluorescence quantification-based large-scale drug screening in complex human iPSC-derived retinal organoids, while providing the speed, sensitivity and reproducibility necessary for this kind of assays. Methods : Transgenic hiPSC lines harboring GFP or YFP fluorescent reporters were generated and induced to differentiate into retinal organoids. Wild type retinal organoids were stained with various fluorescent dyes and used for parameter optimization purposes. Non-stained organoids were used as controls in all experiments. Organoids were seeded into v-bottom 96 well ...
Offered as CHEM 408 and BCBP 408.) This advanced seminar will focus on the ways in which chemical approaches have been used to study and engineer biological systems. We will explore a series of case studies in which the tools of chemistry have been brought to bear on biological questions and seek to answer the following: Did the application of small molecules that were designed and synthesized by chemists allow the researchers to elucidate biological phenomena that would have remained opaque using genetic and biochemical approaches? Do the findings suggest further experiments? If so, could follow-up experiments be carried out with known techniques, or would development of further chemical tools be required? Topics will include: the design and synthesis of chemical modulators of gene expression, signal transduction, and protein-protein interactions; chemical approaches to protein engineering and drug-target validation; activity-based proteomics; and chemical tagging of biomolecular targets. ...
Compugen discovers novel drug targets through a unique, predictive, computational process. We call this process "Predictive Discovery" because our in silico findings predict the biological function and therapeutic relevance of novel proteins which were not previously considered as drug target candidates. For over a decade, we have been developing predictive platforms for a variety of biological processes and phenomena, that are continuously being improved and diversified to address the need for novel targets in areas of interest to the industry.. Biological knowledge: For each biological phenomenon or process, we first screen the available biological literature on the topic. Our scientists study and critically evaluate the publically available information to discern the key components from a computational perspective.. Genome and proteome analysis: The genome is the most complex encryption system known to mankind, and Compugens discovery team has made exceptional progress in understanding and ...
Climate Model Problems: III. Deserts: Whereas climate models based solely on physical and chemical phenomena predict that earths deserts will expand as the airs CO2 content rises, it is found that including the effects of two biological phenomena reverses the predicted trend and suggests that the total area of earths deserts will actually decline as CO2 accumulates in the atmosphere.. Medieval Warm Period Record of the Week ...
If you have a question about this talk, please contact Fiona Roby.. Sentient creatures are ones that have a capacity for feeling; they have the potential to suffer and it is valid to be concerned about their well-being. But the problem with sentience is that it is difficult and problematic to make assumptions about. If we assume that a particular species is sentient, we can be accused of being unparsimonious in our explanations of its behaviour and anthropomorphic in our inferences. If we assume that it isnt, we may find ourselves denying the moral status of an ethically relevant being. In this talk I argue that one pragmatic assumption can and should be made about sentience - that it evolved. Taking this simple step allows us to think about sentience as a biological phenomenon that is present in humans and is likely to have antecedents in other animal species. Even if a completely human-like sentience is not a part of the biological make up of many animals, facets of sentience may be present, ...
A person with pain often asks whether or not pain can be measured and whether pain should be discussed with a physician. To answer this question, its very important to understand that although pain is a natural, biological phenomenon without which a person could not survive, when pain is acute and severe or pain becomes chronic, theres no biological advantage.
We begin from reviewing two concepts, motility in living systems, and active matter (also known as active materials). The main part of the talk is concerned with PDE models of two specific types of active matter: (i) suspensions of swimming bacteria and (ii) active gels that are networks of cross linked filaments subjected to action of energy transducing molecular motors. First we present a brief review of our past work on bacteria swimming in Newtonian fluids and current work in progress of bacteria swimming in liquid crystals. These has been preformed in a close collaboration with experimental group of I. Aronson, who will present a talk on this subject. Next we consider PDE models of motility of eukaryotic cells on a substrate. Our goal is to capture mathematically the key biological phenomena such as steady motion with no external stimuli and spontaneous breaking of symmetry. To this end we study two models of the cells cytoskeleton (active gel): the phase-field model and the free boundary ...
Background Bistability underlies basic biological phenomena, such as cell division, differentiation, cancer onset, and apoptosis. So far biologists identified two necessary conditions for bistability:...
What are the molecular principles of recognition and regulation that underlie such complex biological phenomena? Our attention currently focuses on a pair of molecular adapters - the signal recognition particle (SRP) and the SRP receptor (SR) - that deliver newly synthesized proteins to particular membrane systems within the cell. This process is responsible for the sorting of all the ER resident and secretory proteins within the cell (accounting for roughly one third of cellular proteins) and is essential to establish and maintain the amazing degree of order and organization required to sustain life. ...
NYU School of Medicines Molecular Biophysics PhD Training Program focuses on the molecular mechanisms of a wide array of biological phenomena.
Microfluidic, Devices, Microfluidic Devices, Cell, Cells, Lead, Adsorption, Biotechnology, Concentration, Concentrations, Dyes, Fluorescent Dyes, Glass, Hydrophobicity, Polymer, Polystyrene, Porosity, Time, Antibodies, Biological Phenomena
Surely once you publish a DNA sequence it becomes part of the public domain, and anybody can use it in a manner they see fit (eg. phylogenetic analysis), as long as they cite their source - otherwise there appears to be no point in publishing sequences in the first place. DNA sequence data are no different in this regard from descriptions of morphological characters, being simply observations of tangible biological phenomena. ******************************************************************************* Andrew Mitchell Department of Entomology E-MAIL: moths at phelix.umd.edu University of Maryland College Park, MD 20742 U.S.A ...
According to the beliefs of some scientists (I. S. Shklovsky), life on our planet began approximately 4-4,5 billion years ago. Due to a number of features of development of the Land during the period of its existence has created favorable conditions for the formation of complex organic belkooptorg and other high-molecular compounds in the primary atmosphere (under the influence of electric discharges) and in the water that covered much of the planet (ultraviolet rays). These organic substances, consisting mainly of carbon, hydrogen, oxygen, nitrogen, and many other chemical elements contained in the oceans in large numbers (their concentration in some settlements reached 1%). Their main feature was the ability to retain their chemical composition and physical properties when interacting with countless different chemicals with which they come into contact. This ability was provided education at first very primitive systems - koatservatov it. "The emergence of such systems is not something ...
Howle LE, Weber PW, Vann RD, Campbell MC. Marginal DCS events: their relation to decompression and use in DCS models. J Appl Physiol 107: 1539-1547, 2009. First published August 20, 2009; doi: 10.1152/japplphysiol.00185.2009.-We consider the nature and utility of marginal decompression sickness (DCS) events in fitting probabilistic decompression models to experimental dive trial data. Previous works have assigned various fractional weights to marginal DCS events, so that they contributed to probabilistic model parameter optimization, but less so than did full DCS events. Inclusion of fractional weight for marginal DCS events resulted in more conservative model predictions. We explore whether marginal DCS events are correlated with exposure to decompression or are randomly occurring events. Three null models are developed and compared with a known decompression model that is tuned on dive trial data containing only marginal DCS and non-DCS events. We further investigate the technique by which ...
NAMD is a production molecular dynamics application for biomolecular simulations that include assemblages of proteins, cell-membranes and water molecules. NAMD has demonstrated its performance on several parallel computer architectures. In a biomolecular simulation, the problem-size is fixed and a large number of iterations need to be executed to understand interesting biological phenomenon. Hence we need MD applications to scale to thousands of processors, even though the individual time step available for parallelization is quite small. The Blue Gene/L machine has tens of thousands of embedded Power PC 440 processors. In this paper, we present the challenges we had to overcome to get good sequential performance on the embedded 440 core, by the use of various compiler optimization techniques that use SIMD instructions. We also present several techniques to scale NAMD to 20,480 nodes of Blue Gene/L. These include topology specific optimizations to localize communication, new messaging protocols ...
Trait" is a ubiquitous term in biology, but its precise meaning and theoretical foundations remain opaque. After distinguishing between "trait" and "character," I argue for the value of adopting Theodosius Dobzhanskys 1956 definition and framework for understanding "trait," which holds that traits are just "semantic devices" that artificially impose order on continuous biological phenomena. I elaborate on this definition to distinguish between trait validity (compliance with Dobzhanskys trait definition) and trait utility (usefulness of a trait). As a consequence of this elaboration of the meaning of "trait," it becomes clear that considerations of adaptation, function, homogeneity and natural kinds have clouded discussions of the meaning of "trait" per se. Combining this account with work by David Hull and examples from contemporary biology, I demonstrate that even broad or heterogeneous traits (including multiple sub-traits) can qualify as valid and useful. As a test case for this ...
Molecular Life Sciences: An Encyclopedic Reference will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes.
What makes a living system a living system? What kind of biological phenomenon is the phenomenon of cognition? These two questions have been frequently considered, but, in this volume, the authors, Humberto Maturana and Francisco Varela, consider them as concrete biological questions. Their analysis is bold and provocative, for the authors have constructed a systematic…
Author Summary Recent technology has made it possible to do experiments that show hundreds or even thousands of genes that play a role in a disease or other biological phenomena. Interpreting these experimental results in the light of everything that has ever been published about any of those genes is often overwhelming, and the failure to take advantage of all prior knowledge may impede biomedical research. The computer program described in this paper
Among vertebrate species of the major vertebrate classes in the wild, a seasonal rhythm of whole body fuel metabolism, oscillating from lean to obese condition, is a common biological phenomenon. This annual cycle is driven in part by annual changes in the circadian dopaminergic signaling at the suprachiasmatic nuclei (SCN), with diminution of circadian peak dopaminergic activity at the SCN facilitating development of the seasonal obese insulin resistant condition. The present study investigated whether such an ancient circadian dopamine-SCN activity system for expression of the seasonal obese, insulin resistant phenotype may be operative in animals made obese, insulin resistant by high fat feeding and if so whether reinstatement of the circadian dopaminergic peak at the SCN would be sufficient to reverse the adverse metabolic impact of the high fat diet without alteration of caloric intake ...
What doesnt kill a bug sometimes makes it stronger…or bigger, or longer lived, or able to lay lots and lots of eggs. This biological phenomenon is ca...
The MicroCal PEAQ-ITC is a highly sensitive, low volume isothermal titration calorimeter for the label-free in solution study of biomolecular interactions. It delivers direct measurement of all binding parameters in a single experiment and can analyze weak to high affinity binders, using as little as 10µg sample. Semi-automated maintenance minimizes operator intervention and the system is upgradable to the fully automated MicroCal PEAQ-ITC Automated, making it ideal for laboratories where speed, sensitivity and the ability to accommodate higher workloads in the future are paramount.. ...
Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.
Thin films play an important role in nature and many areas of technological applications. In particular on micro- and nanoscales technological processes such as dewetting or epitaxial growth are used to design surfaces with specific material properties. Apart from the need to derive mathematical decriptions, analyis and numerical simulation, that serve to accelerate the development of new technologies, it is also exciting to understand material behaviour on these small scales.. ...
Computational Intelligence and Neuroscience is a forum for the interdisciplinary field of neural computing, neural engineering and artificial intelligence, where neuroscientists, cognitive scientists, engineers, psychologists, physicists, computer scientists, and artificial intelligence investigators among others can publish their work in one periodical that bridges the gap between neuroscience, artificial intelligence and engineering.
We demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions, specifically peptide-protein interactions. Molecular rotors undergo twisted intramolecular charge transfer upon irradiation, relax via the nonradiative torsional relaxation pathway, and have been typically used as viscosity probes. Their utility as a tool for detecting specific biomolecular interactions has not been explored. Using the well characterized p53-Mdm2 interaction as a model system, we designed a 9-(2-carboxy-2-cyanovinyl) julolidine-based p53 peptide reporter, JP1-R, which fluoresces conditionally only upon Mdm2 binding. The reporter was used in a rapid, homogeneous assay to screen a fragment library for antagonists of the p53-Mdm2 interaction, and several inhibitors were identified. Subsequent validation of these hits using established secondary assays suggests increased sensitivity afforded by JP1-R. The fluorescence of molecular rotors contingent upon target binding makes them ...
We demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions, specifically peptide-protein interactions. Molecular rotors undergo twisted intramolecular charge transfer upon irradiation, relax via the nonradiative torsional relaxation pathway, and have been typically used as viscosity probes. Their utility as a tool for detecting specific biomolecular interactions has not been explored. Using the well characterized p53-Mdm2 interaction as a model system, we designed a 9-(2-carboxy-2-cyanovinyl) julolidine-based p53 peptide reporter, JP1-R, which fluoresces conditionally only upon Mdm2 binding. The reporter was used in a rapid, homogeneous assay to screen a fragment library for antagonists of the p53-Mdm2 interaction, and several inhibitors were identified. Subsequent validation of these hits using established secondary assays suggests increased sensitivity afforded by JP1-R. The fluorescence of molecular rotors contingent upon target binding makes them ...
The work described in this thesis involves the application of direct real-time biomolecular interaction analysis using existing SPR-based biosensors and the development of novel alternative SPR-based technologies. These systems were applied to the investigation of whole cell binding to an immobilised ligand. Solid-phase blood typing was demonstrated by employing monoclonal anti- A IgG and anti-B IgM as affinity ligands for the capture of washed whole red blood cells (RBC). Protein A affinity-capture of anti-A IgG was used as an alternative to direct immobilisation thereby facilitating surface regeneration. A new non-real-time fibre optic-based system (BIACORE Probe) was evaluated using the same affinity-capture format and was successfully applied to direct whole blood typing. Non-real time analysis limited the data quality. Therefore, a similar real-time fibre optic device was constructed. In addition, a miniature SPR-based biosensor employing a single platform optical configuration was ...
Super-resolution optical fluctuation imaging (SOFI) allows one to perform sub-diffraction fluorescence microscopy of living cells. By analyzing the acquired image sequence with an advanced correlation method, i.e. a high-order cross-cumulant analysis, super-resolution in all three spatial dimensions can be achieved. Here we introduce a software tool for a simple qualitative comparison of SOFI images under simulated conditions considering parameters of the microscope setup and essential properties of the biological sample. This tool incorporates SOFI and STORM algorithms, displays and describes the SOFI image processing steps in a tutorial-like fashion. Fast testing of various parameters simplifies the parameter optimization prior to experimental work. The performance of the simulation tool is demonstrated by comparing simulated results with experimentally acquired data.. ...
http://cran.r-project.org/web/packages/aphid. Designed for the development and application of hidden Markov models and profile HMMs for biological sequence analysis. Contains functions for multiple and pairwise sequence alignment, model construction and parameter optimization, file import/export, implementation of the forward, backward and Viterbi algorithms for conditional sequence probabilities, tree-based sequence weighting, and sequence simulation. Features a wide variety of potential applications including database searching, gene-finding and annotation, phylogenetic analysis and sequence classification.. Maintainer: Shaun Wilkinson ...
Advances in such fields as proteomics and genomics place new demands on students and professionals to be able to apply quantitative concepts to the biological phenomena that they are studying. Spectroscopy for the Biological Sciences provides students and professionals with a working knowledge of the physical chemical aspects of spectroscopy, along with their applications to important biological problems ...
Bioengineering combines the analytical and experimental methods of the engineering profession with the biological and medical sciences to achieve a more detailed understanding of biological phenomena and to develop new techniques and devices. The engineers quantitative and analytical approach; traditional competence in the processing and control of information, energy, and materials; and ability to design and analyze systems are powerful tools when applied to biology, medicine; and …
My name is Clemente Aguilar and I love science. I am a postdoctoral fellow at the National Institute for Mathematical and Biological Synthesis (NIMBioS) and my way to understand biological phenomena is by mixing knowledge from the areas of biology, statistics, and computer programming. In the past I have worked in the development of computational methods for mass spectrometry data analysis, particularly in the identification of glycolipids and proteins. Most recently I have become interested in anything related with the immune system; specifically my current research is focused on developing efficient algorithms for epitope prediction ...
This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including ... More. This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including humans). The scope extends beyond the target organism to consider the ecosystem-level dynamics of migration. Rather than simply reviewing the field of migration as it stands today, the book highlights the lacunae in our knowledge and understanding. The emphasis is on exciting new research avenues that are now opening up, whether because of advances in our understanding of migration as a biological phenomenon or through the availability of a range of new technologies. Broad themes that emerge include smoothly integrating migration into the broad spectrum of movement behaviour; the need for a comparative ...
This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including ... More. This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including humans). The scope extends beyond the target organism to consider the ecosystem-level dynamics of migration. Rather than simply reviewing the field of migration as it stands today, the book highlights the lacunae in our knowledge and understanding. The emphasis is on exciting new research avenues that are now opening up, whether because of advances in our understanding of migration as a biological phenomenon or through the availability of a range of new technologies. Broad themes that emerge include smoothly integrating migration into the broad spectrum of movement behaviour; the need for a comparative ...
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.[138] Model organisms are in vivo models and are widely used to research human disease when human experimentation would be unfeasible or unethical.[139] This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution.[140] Studying model organisms can be informative, but care must be taken when extrapolating from one organism to another.[141]. In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming a human. The species chosen will usually meet a determined taxonomic equivalency to humans, so as to react to disease or its treatment in a way that resembles human ...
Chai, J., Shiozaki, E., Srinivasula, S. M., Wu, Q., Datta, P., Alnemri, E. S., Shi, Y., Dataa, P. (2001). Structural basis of caspases-7 inhibition by XIAP. Cell. 104:769-780 El-Deiry, W. S., Jin, Z. (2005). Overview of cell death signalling pathways. Cancer biology and therapy. 4(2):139-163 Fadeel, B., Orrenius, S. (2005). Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. Journal of internal medicine. 258:479-517 Fischer, U., Schulze-Osthoff, K. (2005). Apoptosis-based therapies and drug targets. Cell death and differentiation. 12:942-961 Gewies, A. (2003). Introduction to apoptosis. Aporeview. 1-26 Mazumder, S., Plesca, D., Almasan, A. (2005). Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods in molecular biology. 414:13-21 Ranger, A. M., Malynn, B. A., Korsmeyer, S. J. (2001). Mouse models of cell death. Nat genet. 28:113-118 Riedl, S. J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S. W., ...
This course will explore a diverse collection of striking biological phenomena associated with the X chromosome. We will examine the genetic basis and
Unique coherent compendium of the theoretical underpinnings of thin film dynamics, in particular their instabilities Presents a large range of
A method for processing image data includes estimating initial factor images from image data, transforming the estimated initial factor images by a transformation variable to obtain transformed factor images, providing an objective function that is a function of the transformed factor images, and minimizing the objective function to obtain unique factor images from the estimated initial factor images.
The paper presents simulation studies targeting high-power narrow-linewidth emission from semiconductor distributed feedback (DFB) lasers. The studies contain analytic and numerical calculations of emission linewidth, side mode suppression ratio and output power for DFB lasers without phase shifts and with 1 × λ/ 4 and 2 × λ/ 8 phase shifts, taking into account the grating and facets reflectivities, the randomness of the spontaneous emission and the longitudinal photon and carrier density distributions in the laser cavity. Single device structural parameter optimization is generally associated with a trade-off between achieving a narrow linewidth and a high output power. Correlated optimization of multiple structural parameters enables the evaluation of achievable ranges of narrow linewidth and high power combinations. Devices with long cavities and low grating coupling coefficients, κ (keeping κL values below the levels that promote re-broadening), with AR-coated facets and with a ...
M. Amin, Sri Yulis and Jamaludin, Khairur Rijal and Muhamad, Norhamidi (2009) Rheological properties of SS316l MIM feedstock prepared with different particle sizes and powder loadings. The Journal of the Institution of Engineers, Malaysia, 7 (2). pp. 59-63. ISSN 0126-513X Mazlan, Khalid (Penyelenggara) (2009) Gaya & panduan penerbitan book chapters. Penerbit UTM, Skudai, Johor Bahru. ISBN 978-983-52-0703-7 Md. Zain, Ahmad Rifqi (2009) One - dimensional photonic crystal/photonic wire cavities based on silicon - on - insulator (SOL). PhD thesis, University of Glasgow. Mohamad, Khairul Azmi and Othman, Nooraini (2009) Nilai yang mendasari integriti dan amalan masyarakat hadhari. In: Ke Arah Umat Hadhari. Yayasan Ilmuwan, Kuala Lumpur, Malaysia. ISBN 978-983-44372-1-3 Mohamad Nor, Nor Hafiez and Muhamad, Norhamidi and Ismail, M. H. and Jamaludin, Khairur Rijal and Ahmad, S. and Ibrahim, M. H. I. (2009) Injection molding parameter optimization of titanium alloy powder mix with palm stearin and ...
As a graduate student in physics, I recognized the immense opportunities offered by using physical methods and physics-based approaches to study biological function. At the time, I became intrigued by the complexity of biological phenomena, and was captivated by the challenges of reducing this complexity to basic physical principles at the molecular level. I was impressed by advances in structural and computational biology, based largely on physical techniques, that enabled us to look intimately into three-dimensional structures of biological molecules and study forces that keep structures together, influence biomolecular dynamics, and drive biomolecular interactions. As time passed, I developed an appreciation for pathways and networks within and between cells, tissues, organs, and organisms, as well as for bioengineering applications based on biophysical studies.. Why did you decide to get involved with publishing?. Scientific research and publication are interweaved. Publication is the only ...
This dataset contains the digitized treatments in Plazi based on the original journal article Pérez-González, Abel, Sharma, Prashant P., Proud, Daniel N. (2016): Morphological tricks and blessed genitalia: rectifying the family placement of Fijicolana tuberculata (Opiliones: Laniatores: Zalmoxidae). Zootaxa 4061 (3): 253-260, DOI: http://doi.org/10.11646/zootaxa.4061.3.3 ...
The new theoretical physics and statistical mechanics group at Universite Montpellier II in Montpellier, France is seeking candidates for 1 PhD student position (3 years - start: September/October 2012) and 1 postdoctoral fellow position (1 year + possibilities for extension - start: Fall-Winter 2012-2013). Topics to be studied include: i) motor protein dynamics in intracellular phenomena; ii) non-equilibrium classical transport at molecular scales; iii) collective transport phenomena on complex networks; and iv) interface theory/experiments. Candidates profile: interest for analytical/numerical approaches in biophysics and theoretical physics inspired by biological phenomena, statistical mechanics, stochastic processes, nonlinear phenomena. Contact Prof. Andrea Parmeggiani at [email protected] ...
2016. Grulich M, Brezovsky J, Stepanek V, Palyzova A, Maresova H, Zahradnik J, Kyslikova E, Kyslik P, 2016: In-silico Driven Engineering of Enantioselectivity of a Penicillin G Acylase towards Active Pharmaceutical Ingredients. Journal of Molecular Catalysis B: Enzymatic 133: S53-S59. full text.. Brezovsky J,* Babkova P,* Degtjarik O, Fortova A, Gora A, Iermak I, Rezacova P, Dvorak P, Kuta Smatanova I, Prokop Z, Chaloupkova R, Damborsky J, 2016: Engineering a De Novo Transport Tunnel. ACS Catalysis 6: 7597-7610. full text Marques SM, Daniel L, Buryska T, Prokop Z, Brezovsky J, Damborsky J, 2016: Enzyme Tunnels and Gates as Relevant Targets in Drug Design. Medicinal Research Reviews 37: 1095-1139. full text. Bendl J, Musil M, Stourac J, Zendulka J, Damborsky J,# Brezovsky J,# 2016: PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions. PLoS Computational Biology 12: e1004962. full text. Bendl J, ...
This meeting united participants from the fields of experimental epigenetics, mathematics and computational biology, to discuss results and challenges in the endeavour to explore points of synergy between these fields. The design shown here expresses the idea of moving complex biological phenomena (left nucleosome) towards precise mathematical descriptions (right nucleosome). ...
Our group is interested in using computers to understand biological phenomena, via data analysis, modelling and prediction. Our main focus at present is on the area of quantitative proteomics: how can we measure the levels of all the individual proteins in cells and tissues, and understand how these levels change in different conditions, as well as under stress. We are working on methods to do this in collaboration with mass spectrometrists and protein chemists, developing software for experimental design and downstream analysis of results, using yeast and the fruit fly as model systems. In parallel, we are analysing experimental RNA sequencing data in yeast to understand how cells regulate the translation of mRNA in to proteins, a fundamental process of molecular biology which is now know to play a significant role in the regulation of gene expression, particularly under stress conditions.. ...
For our final project, we chose to help Quentin organize some information that he had been acquiring for his preliminary exam. At first, Emily and Kate had little idea what Quentins project was on. Quentin was quoted to say "Glycosyltransferase…it puts sugars on lots of stuff". To unravel the mystery surrounding this enzyme, the trio worked together with a few tools that were learned during this weeks workshop.. Wordle: Generation of the wordle showed key words and phrases that hinted at the functioning of this enzyme. We used the first paragraph from wikipedia to create this wordle. End-note: The main method that Quentin used to organize his literary resources was End-Note. Emily and Kate created accounts so they could have access to the journal articles. We found that EndNote was a great tool to not only organize resources but to create in-text citations and bibliographies. Some of the journal articles listed above pointed out how glycolsylation is a pivotal biological phenomena that allows ...
Adenosine, Forebrain, Sleep, Eeg, Rats, Sleep Deprivation, Neurons, ATP, Brain, Eye, Eye Movement, Movement, Rapid Eye Movement, Membrane, Nitric Oxide, Wakefulness, Time, AMP, Amp-activated Protein Kinase, Biological Phenomena
In life, timing is everything. There is a new buzzword in cancer therapy, Chronobiology. Simply put, this means the study of clocklike stuff in living things. Or you can use the brainier definition, Chronobiology is the quantitative study of rhythmic temporal relationships in biological phenomena. Our bodies go through a day as if multiple clocks were hardwired into our brains, organs, and very cells telling us what to do and when to do it. In recent years scientists have just begun to understand these multiple rhythms of activity and rest that different systems in the body go through on a daily basis. These daily, or circadian, cycles repeat themselves every 24 hours. Cells dont grow at a constant rate; rather there are bursts of frantic cell division followed by rest spells. Hormones are not generated at a steady flow rate but have high points when they are dumped into the blood and low points throughout the day. All animals have built in clocks in not just their bodies but in their ...
As if that werent enough, from time to time I get an email with a photo of some biological oddity or other (usually something I cant myself identify). This photo in particular caught my eye. One, because it is truly strange, and 2) because it represents one of the coolest and weirdest biological phenomena I know.. The strange plant part in the photo is called a gall. A gall is a structure that a plant creates, not of its own accord, but after being induced to do so, usually by an insect or a mite. The animal injects a particular chemical into the plant, and the plant responds by growing a very distinctive, protective structure that provides shelter to the animal. Often, the galls are also filled with nutritious starch, feeding the growing larvae as well as housing it.. This particular gall was found on a Sitka spruce, and is known as a Cooley spruce gall. In it lives the larvae of a spruce adelgid, and insect much like an aphid. The galls are induced generally on the new growth of the trees, ...
AMHERST, Mass. -- Scoffing at or cutting funds for basic biological research on unusual animal adaptations from Gila monster venom to snail sex, though politically appealing to some, is short-sighted and only makes it more likely that important economic and social benefits will be missed in the long run, say a group of evolutionary biologists at the University of Massachusetts Amherst.. Writing in a recent issue of BioScience, researchers Patricia Brennan, Duncan Irschick, Norman Johnson and Craig Albertson argue that "innovations often arise from unlikely sources" and "reducing our ability to creatively examine unique biological phenomena will ultimately harm not only education and health but also the ability to innovate, a major driver of the global economy.". First author Brennan, known for her duck genitalia studies that could eventually aid human medical science points out, "Basic science has increasingly come under attack, and there is a growing perception that studying odd science ideas ...
The MAMBE curriculum is founded on the idea that interdisciplinary thinking enhances in-depth understanding of biological phenomena. For example, the complexity that are characteristic for many molecular processes can often only be understood by taking into account their evolutionary origin. Similarly, the evolution of particular trait functions may also often depend on the underlying molecular mechanisms. MAMBE will foster such interdisciplinary connections. In the first two semesters, you will learn about the basic mechanisms and processes of molecules and evolution. Additionally, you will enhance your skill set in scientific communication and management (e.g., preparation of seminar talks, or writing of grant applications, etc). During the third semester, the acquired competences will be applied to real research life in the laboratory and field. The fourth semester will consist of your Master thesis.. ...
Click here to receive the Jeff Zeig show guide! Stages of Love: Love is a biological phenomenon that has three different stages, each with their own neurobiology. The first is the Stage of Attraction; this is when we discover someone who we feel drawn to. The next is the Stage of Attachment; this is a stage of luminance, which is marked with high sexual activity, an intense desire to find similarities, and a sense that you cannot get enough of each other. This stage then evolves into the Bonding stage in which we choose our partner as our mate. At this stage the neurochemicals secreted naturally drive down sexual desire. This decrease in dopamine rich sexual activity can become a crisis for couples who do not understand that there is a biological context influencing this change and instead create stories of lost connection or attraction.. Shakespeare was right- love is blind. In the luminance stage we are nearly incapable of seeing our partner for who they truly are. In fact, we see them through ...
Author Summary Coevolution between hosts and parasites is believed to be central to a number of biological phenomena, most notably the observed patterns of biodiversity and the origins of sexual reproduction. However, classical mathematical models of host-parasite coevolution account neither for the hosts use of bacterial symbionts for protection from parasites, nor for the potential and observed complexity of genetic interactions between the coevolving species. In this article we address both challenges by simulating a large number of models of host-symbiont-parasite coevolution based on randomly generated genotype interaction patterns. We demonstrate that the degree of
Colorectal tumors originate and develop within intestinal crypts. Even though some of the essential phenomena that characterize crypt structure and dynamics have been effectively described in the past, the relation between the differentiation process and the overall crypt homeostasis is still partially understood. We here investigate this relation and other important biological phenomena by introducing a novel multiscale model that combines a morphological description of the crypt with a gene regulation model: the emergent dynamical behavior of the underlying gene regulatory network drives cell growth and differentiation processes, linking the two distinct spatio-temporal levels. The model relies on a few a priori assumptions, yet accounting for several key processes related to crypt functioning, such as: dynamic gene activation patterns, stochastic differentiation, signaling pathways ruling cell adhesion properties, cell displacement, cell growth, mitosis, apoptosis and the presence of ...
Its easy to brush Qi under the table as laughable prescientific vitalism, but one should keep it firmly in mind that this concept is actually one of the things that tends to attract people to alternative views. As its used in TCM, it is totally vitalism: I grant that without the slightest reservation or hesitation. But, there is an empirical phenomenon here that you shouldnt overlook, which has a very strong amount of sway on people. I know that statement will sound immediately woo-y, but please allow me to elaborate.. Qi comes out of a culture that made a series of observations about biological phenomena but lacked any sort of framework of names to grant to those observations or to explain how those observations related to one another. There was no theory of cells, no notion of hormones and certainly no practical concept of nerves or any microscopic structures, but they did have observations about their bodies that they needed to some catch-all term to identify. In China, you have Taoist and ...
Biological phenomena are so complex that they can be logically explained only in the light of evolution. Evolution therefore has to be brought into picture while studying any aspect of zoology, namely, anatomy, embryology, cytology or physiology. The fact that animals and plants change and do not remain static during the course of time is the backbone of evolutionary reasoning. Dobzhanskys view that nothing makes sense in biology except in the light of evolution outlines the importance of this branch of science. The word evolution simply means a change with time, and organic evolution means change in plants and animals from generation to generation, which Darwin called, "descent with modification".. Evolution is the outcome of interaction of organisms with their environment. As animals try to adapt to the changing environment, adaptive structures arise by gradual change in the existing organs, which over a period of time accumulate to form large anatomical changes that we call marvels of ...
Biological phenomena are so complex that they can be logically explained only in the light of evolution. Evolution therefore has to be brought into picture while studying any aspect of zoology, namely, anatomy, embryology, cytology or physiology. The fact that animals and plants change and do not remain static during the course of time is the backbone of evolutionary reasoning. Dobzhanskys view that nothing makes sense in biology except in the light of evolution outlines the importance of this branch of science. The word evolution simply means a change with time, and organic evolution means change in plants and animals from generation to generation, which Darwin called, "descent with modification".. Evolution is the outcome of interaction of organisms with their environment. As animals try to adapt to the changing environment, adaptive structures arise by gradual change in the existing organs, which over a period of time accumulate to form large anatomical changes that we call marvels of ...
The electrical double layer (EDL) is formed due to the accumulation of charge at the interface of a metal surface in contact with an electrolyte. The total charge in the EDL compensates the charge on the metal surface. As EDL is the layer that "connects" the electrode to the "bulk", all electrode mediated transport and redox reaction depends on the structure and dynamics of the ions in the EDL. Thus the ion dynamics in the EDL are critical to a wide range of physical and biological phenomena such as electrochemical reaction, flow in channels of nanofluidic devices, wetting of fluids; to biology, for example, folding and function of proteins, conformation change of DNA and ionic flow through cell membranes. EDL polarization is the ion accumulation or depletion in the EDL due to the potential of the metal surface. The conventional method of measuring the EDL polarization is by monitoring the current flowing through the electrochemical system. Thus, the electrical characteristics of the EDL are ...
Kathrin Stavenhagen: Glycopeptide analysis remains challenging because of its sample heterogeneity resulting from the degree of glycosylation site occupancy (macroheterogeneity) and the different glycoforms attached to individual glycosylation sites (microheterogeneity).. With respect to the latter one, qualitative site-specific glycosylation information of glycoproteins can be obtained by unspecific protease treatment resulting in small amino acid stretches carrying the glycan. This improves determination of the glycosylation sites. However, detecting these glycopeptides by 1D-LC-ESI-MS/MS is challenging due to insufficient or irreversible retention on the stationary phase and thus multiple analyses with different LC-setups are required. Since biological sample amounts are usually limited, methods for acquiring comprehensive information in a single run are necessary.. To obtain qualitative information of the glycosylation site we set up an integrated C18-porous graphitized carbon ...
Wind speed forecasting plays a key role in wind-related engineering studies and is important in the management of wind farms. Current forecasting models based on different optimization algorithms can be adapted to various wind speed time series data. However, these methodologies cannot aggregate different hybrid forecasting methods and take advantage of the component models. To avoid these limitations, we propose a novel combined forecasting model called SSA-PSO-DWCM, i.e., particle swarm optimization (PSO) determined weight coefficients model. This model consisted of three main steps: one is the decomposition of the original wind speed signals to discard the noise, the second is the parameter optimization of the forecasting method, and the last is the combination of different models in a nonlinear way. The proposed combined model is examined by forecasting the wind speed (10-min intervals) of wind turbine 5 located in the Penglai region of China. The simulations reveal that the proposed combined model

Memory Booster, Aha Moments and Biological Quantum Phenomena | ScienceBlogsMemory Booster, Aha Moments and Biological Quantum Phenomena | ScienceBlogs

That phenomenon is spin selection - a preference for one of the two directions of angular momentum in subatomic particles. A ... Yet, it turns out that a phenomenon that physicists can normally only observe at extremely low temperatures can take place in ... Memory Booster, Aha Moments and Biological Quantum Phenomena Memory Booster, Aha Moments and Biological Quantum Phenomena * ...
more infohttps://scienceblogs.com/weizmann/2011/03/31/memory-booster-aha-moments-and

The Biological Significance of Evolution in Autoimmune PhenomenaThe Biological Significance of Evolution in Autoimmune Phenomena

... Carlos A. Cañas1 and Felipe Cañas2 ... Teleost fish has TNF-α and TNF-α receptors and the human recombinant TNF-α produces biological effects such as macrophage ... Delineation of a new class of IL-1R-related proteins based on signaling," Journal of Biological Chemistry, vol. 275, no. 39, pp ... 2. Influence of the First Form of Evolutionary Memory on the Autoimmune Phenomena. Innate immunity is a system that does not ...
more infohttps://www.hindawi.com/journals/ad/2012/784315/

9780131569881 - Transport Phenomena in Biological | eCampus.com9780131569881 - Transport Phenomena in Biological | eCampus.com

9780131569881 Our cheapest price for Transport Phenomena in Biological Systems is $123.86. Free shipping on all orders over $ ... Transport Phenomena in Biological Systems. by Truskey, George A.; Yuan, Fan; Katz, David F. *ISBN13: 9780131569881. ... of research and their research has involved various aspects of momentum and mass transport related to biological phenomena and ... Presenting engineering fundamentals and biological applications in a unified way, this book provides learners with the skills ...
more infohttps://www.ecampus.com/transport-phenomena-biological-systems/bk/9780131569881

Transport Phenomena in Biological SystemsTransport Phenomena in Biological Systems

... (BOK) George A. Truskey, Fan Yuan, David F. Katz Del ... Presenting engineering fundamentals and biological applications in a unified way, this text provides students with the skills ... with engineering concepts motivated by specific biological problems. ... necessary to develop and critically analyze models of biological transport and reaction processes. It covers topics in fluid ...
more infohttps://www.platekompaniet.no/bok/transport-phenomena-in-biological-systems-george-a-truskey/

New publication in J. Phys. Chem. B |  Quantum Phenomena and Nanoscale Biological SystemsNew publication in J. Phys. Chem. B | Quantum Phenomena and Nanoscale Biological Systems

Quantum Phenomena and Nanoscale Biological Systems. News. * New publication in Elife with new optical tweezer data on molecular ... thereby controlling a wide variety of biological processes including brain function and heartbeat. Ion channels are generally ...
more infohttps://www.univie.ac.at/qunabios/?p=1765

Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological PhenomenaCharacterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena

... Carina Trojahn, Gabor ... Despite extensive research over the past decades, there is no consensus upon a biological marker for human ageing [13]. The ... Although conceptually distinct, the clinical phenomena facial skin ageing, wrinkling and sagging seem to be closely related to ... Furthermore we tried to disentangle primarily intrinsic from extrinsic ageing phenomena.. Most of the investigated parameters ...
more infohttps://www.hindawi.com/journals/bmri/2015/318586/

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.  - PubMed - NCBIApoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. - PubMed - NCBI

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.. Kerr JF, Wyllie AH, Currie AR. ... Its morphological features suggest that it is an active, inherently programmed phenomenon, and it has been shown that it can be ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/4561027?dopt=Abstract

Probing Biological Light-Harvesting Phenomena by Optical CavitiesProbing Biological Light-Harvesting Phenomena by Optical Cavities

... Physical Review B 85(12): 125424. ... This approach provides us with a spectroscopic tool to interrogate biological systems in terms of quantum optical phenomena ...
more infohttps://dash.harvard.edu/handle/1/8641796?gathStatIcon=true

Biological clock found in fungal parasite sheds more light on zombie ants phenomenon | EurekAlert! Science NewsBiological clock found in fungal parasite sheds more light on 'zombie ants' phenomenon | EurekAlert! Science News

A working biological clock has been found in a fungal parasite that infects ants to control their behavior and lead them away ... biological-clock-found-fungal-parasite-sheds-light-zombie-ants-phenomenon/. More in Biology. * Making an eye for you Kyoto ... Biological clock found in fungal parasite sheds more light on zombie ants phenomenon. University of Central Florida ... Biological clock found in fungal parasite sheds more light on zombie ants phenomenon ...
more infohttps://eurekalert.org/pub_releases/2017-11/uocf-bcf110617.php

Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses - Journal of Materials...Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses - Journal of Materials...

Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses N. P. Murphy and K. J. ... Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2014/tb/c5tb01045d

BJNANO - Biological and biomimetic surfaces: adhesion, friction and wetting phenomenaBJNANO - Biological and biomimetic surfaces: adhesion, friction and wetting phenomena

... friction and wetting phenomena is a Thematic Issue edited by Stanislav N. Gorb, Kerstin Koch and Lars Heepe in the Open Access ... Biological and biomimetic surfaces: adhesion, friction and wetting phenomena. *. *Editors. Prof. Stanislav N. Gorb, Christian- ... Biological and biomimetic surfaces: adhesion, friction and wetting phenomena *Stanislav N. Gorb, ... Biological surfaces are the interface between organisms and the environment and serve a multitude of different functions. This ...
more infohttps://www.beilstein-journals.org/bjnano/series/62

Numerical modelling of the growth and remodelling phenomena in biological tissuesNumerical modelling of the growth and remodelling phenomena in biological tissues

CitationComellas Sanfeliu, E. "Numerical modelling of the growth and remodelling phenomena in biological tissues". Tesi ... Living biological tissues are complex structures that have the capacity of evolving in response to external loads and ... A growth model considering biological availability is used and extended to include directional growth. In addition, a novel ... The adequate modelling of soft biological tissue behaviour is a key issue in successfully reproducing biomechanical problems ...
more infohttps://upcommons.upc.edu/handle/2117/108955

Review article  Motor activity phenomenon in anorexia nervosa - biological aspects	
	Review article Motor activity phenomenon in anorexia nervosa - biological aspects

Motor activity phenomenon in anorexia nervosa - biological aspects. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and ... Motor activity phenomenon in anorexia nervosa - biological aspects. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and ... Motor activity phenomenon in anorexia nervosa - biological aspects". Neuropsychiatria i Neuropsychologia/Neuropsychiatry and ... Motor activity phenomenon in anorexia nervosa - biological aspects. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and ...
more infohttps://www.termedia.pl/Review-article-Motor-activity-phenomenon-in-anorexia-nervosa-8211-biological-aspects,46,12603,0,1.html

Condensed Matter seminar: Life as an emergent phenomenon: how local interactions lead to biological function at the global...Condensed Matter seminar: 'Life as an emergent phenomenon: how local interactions lead to biological function at the global...

Condensed Matter seminar: Life as an emergent phenomenon: how local interactions lead to biological function at the global ... Life exists by virtue of collective phenomena. From the cells in a tissue down to the proteins inside a cell, cooperation is ... We study the physics of these many-component systems, looking for the emergent behaviour that underlies many biological ...
more infohttps://www.physics.upenn.edu/events/condensed-matter-seminar-tba-14

Connecting empirical phenomena and theoretical models of biological coordination across scales - Complexity Digests blog -...Connecting empirical phenomena and theoretical models of biological coordination across scales - Complexity Digest's blog -...

Connecting empirical phenomena and theoretical models of biological coordination across scales. Mengsen Zhang , Christopher ... It also connects empirically validated models of large- and small-scale biological coordination-the Kuramoto and extended Haken ... Analyses and modelling of empirically observed patterns of biological coordination often focus either on ensemble-level ... Bunz (HKB) models-and the hallmark phenomena that each is known to capture. For example, it exhibits both multistability and ...
more infohttps://www.moneyscience.com/pg/blog/ComplexityDigest/read/882580/connecting-empirical-phenomena-and-theoretical-models-of-biological-coordination-across-scales

Connecting empirical phenomena and theoretical models of biological coordination across scales - Complexity Digests blog -...Connecting empirical phenomena and theoretical models of biological coordination across scales - Complexity Digest's blog -...

Connecting empirical phenomena and theoretical models of biological coordination across scales. Mengsen Zhang, Christopher ... It also reconciles in a single formulation two well-studied models of large- and small-scale biological coordination (Kuramoto ... We show that second-order coupling is indispensable for reproducing empirically observed phenomena and gives rise to a phase ... The present work bridges this gap with a theoretical model of biological coordination that captures key experimental ...
more infohttp://www.moneyscience.com/pg/blog/ComplexityDigest/read/839232/connecting-empirical-phenomena-and-theoretical-models-of-biological-coordination-across-scales

Biological role for synthesis and release of isoprene by photosynthesizing cells in view of the entropy phenomenon, Russian...Biological role for synthesis and release of isoprene by photosynthesizing cells in view of the entropy phenomenon, Russian...

"Biological role for synthesis and release of isoprene by photosynthesizing cells in view of the entropy phenomenon, Russian ... Biological role for synthesis and release of isoprene by photosynthesizing cells in view of the entropy phenomenon. Biological ... Biological role for synthesis and release of isoprene by photosynthesizing cells in view of the entropy phenomenon. Sanadze, G. ... The cell functioning can be viewed as energy flows and matter conversions occurring on biological matrices. The flows of ...
more infohttps://www.deepdyve.com/lp/springer_journal/biological-role-for-synthesis-and-release-of-isoprene-by-0wrzMDAsQW

Modeling of transport phenomena of nano-particles in biological media in electromagnetic fields - IOS PressModeling of transport phenomena of nano-particles in biological media in electromagnetic fields - IOS Press

The mathematical formulation of the transport phenomena given in the article is based on sys ... This article introduces a theory of studying transport phenomena of charged or polarizable nano-particles in some biological ... Modeling of transport phenomena of nano-particles in biological media in electromagnetic fields Article type: Research Article ... The theory may be used not only for analyzing transport phenomena of some nano-drug carriers in drug delivery systems, but also ...
more infohttps://content.iospress.com/articles/international-journal-of-applied-electromagnetics-and-mechanics/jae00781

Fundamentals of Cryobiology: Physical Phenomena and Mathematical Models (Biological and Medical Physics, Biomedical Engi -...Fundamentals of Cryobiology: Physical Phenomena and Mathematical Models (Biological and Medical Physics, Biomedical Engi -...

Biological and Medical Physics, Biomedical Engi, Alexander I. Zhmakin - 9783540887843. Find the lowest prices on SlugBooks ... Fundamentals of Cryobiology: Physical Phenomena and Mathematical Models (Biological and Medical Physics, Biomedical Engi. by ... covering the basics and the state-of-the-art of cryobiology and its applications emphasizes the underlying physical phenomena. ...
more infohttps://www.slugbooks.com/9783540887843-fundamentals-of-cryobiology-physical.html

Transport Phenomena | MIT Department of Biological EngineeringTransport Phenomena | MIT Department of Biological Engineering

Transport Phenomena. Transport phenomena is the study of transfers. Typically, it refers to three thransfer studies: Heat ... there are faculty studying the exclusion or passage of molecules through mucus barriers and other transport phenomena-related ... Transfer, Mass Transfer, and Fluid Mechanics(Momentum Transfer). In Biological Engineering, ...
more infohttps://be.mit.edu/research-areas/transport-phenomena

Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide...Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide...

The finding suggests that recurrence is a distinct biological phenomenon from the formation of primary pterygium, even though ... Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide ... Biological function of dysfunctional genes. Pie Charts showing the percentage of genes with different biological functions that ... The identities and biological/molecular functions of these relationships are shown in Additional files 2 and 3.. ...
more infohttps://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-2-14

An Introduction to Maturanas BiologyAn Introduction to "Maturana's" Biology

Observing Biological Phenomena. At this point, let us take stock of the ground we have covered so far. We can make some useful ... Observing Biological Phenomena *Implications for Human Behaviour *Our Culture Perhaps we can be forgiven for trying to ... Along with growth and development, reproduction is described in our view as one of the biological phenomena - observable only ... We are going to say a lot about matters which we will distinguish as biological autonomy and the process of cognition. These ...
more infohttps://www.univie.ac.at/constructivism/pub/seized/matsbio.html

Medical search (Biological Phenomena • Definitions)Medical search (Biological Phenomena • Definitions)

Intervention in Biological Phenomena Modeled by S-Systems - CBGSE. Intervention in Biological Phenomena Modeled by S-Systems. ... Transport Phenomena in Biological Systems (Second ed. (wikipedia.org). *Book Review: Transport Phenomena in Biological Systems ... and other interesting biological phenomena , Page 6. and other interesting biological phenomena. Search. Main menu. Skip to ... and other interesting biological phenomena , Page 5. and other interesting biological phenomena. Search. Main menu. Skip to ...
more infohttps://lookformedical.com/search.php?lang=1&q=Biological+Phenomena

Spying minority in biological phenomenaSpying minority in biological phenomena

... A Grant-in-Aid for Scientific Research on Innovative Areas, MEXT (2011-2016) ...
more infohttp://paradigm-innovation.jp/en/index.html

Spying minority in biological phenomenaSpying minority in biological phenomena

The phenomenon of life is considered to be based on the "cooperative" functioning of nanosystems composed of a small number of ... In this project, we aim to establish an appropriate theory that will aid in future experiments on biological systems. ...
more infohttp://paradigm-innovation.jp/en/outline/outline_index.html
  • Pkhachiashvili, S. 2016-04-01 00:00:00 In this review, the issues of photobiological synthesis and release of isoprene by chlorophyll-containing cells are considered from the viewpoint of thermodynamics of open nonequilibrium systems, with an emphasis on fundamental significance of the entropy phenomenon. (deepdyve.com)
  • The authors are leaders in their respective fields of research and their research has involved various aspects of momentum and mass transport related to biological phenomena and technologies. (ecampus.com)
  • The active behaviour of tissues is characterized through constitutive models capable of reproducing the growth and remodelling phenomena. (upc.edu)
  • A growth model considering biological availability is used and extended to include directional growth. (upc.edu)
  • For example, it exhibits both multistability and metastability observed in small-scale empirical research (via the second-order coupling and symmetry breaking in extended HKB) and the growth of biological complexity as a function of scale (via the scalability of the Kuramoto model). (moneyscience.com)
  • In particular, we intent to cover all aspects of the biomimetic process, starting from biological prototypes, characterization of surface-related phenomena, fabrication of biomimetic materials, to novel concepts. (beilstein-journals.org)
  • Biological role for synthesis and release of isoprene by photosynthesizing cells in view of the. (deepdyve.com)
  • Es basa en models fenomenològics que, usats en combinació amb la teoria de mescles generalitzada, permeten reproduir numèricament un ampli ventall de comportaments materials. (upc.edu)
  • Primer, el comportament passiu dels teixits es caracteritza amb models hiperelàstics i de dany en grans deformacions. (upc.edu)
  • Llavors, es descriu l'ús d'aquests models constitutius en conjunt amb la teoria generalitzada de mescles, desenvolupada en el marc de grans deformacions, i es presenten eines que permeten incorporar les propietats anisòtropes dels teixits. (upc.edu)
  • Neuropsychological aspects and the hyperactivity phenomenon in animal models of anorexia nervosa were reviewed. (termedia.pl)
  • Living biological tissues are complex structures that have the capacity of evolving in response to external loads and environmental stimuli. (upc.edu)
  • De Bekker sees the role of biological clocks in infectious diseases as the next big thing for scientists to study. (eurekalert.org)
  • In western societies females seem to be very concerned about their facial appearance and visible ageing phenomena indicated by increasing expenditures for cosmetic products and aesthetic procedures [ 12 ]. (hindawi.com)
  • Scientists can better understand how diseases internally impact humans by knowing more about parasites and their impact on the biological clock. (eurekalert.org)