Thymopentin: Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Breast Neoplasms: Tumors or cancer of the human BREAST.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Biotin: A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Karyotyping: Mapping of the KARYOTYPE of a cell.Ploidies: The degree of replication of the chromosome set in the karyotype.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Cell Line, Tumor: A cell line derived from cultured tumor cells.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Leukemia, Lymphocytic, Chronic, B-Cell: A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Translocation, Genetic: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.DNA, Neoplasm: DNA present in neoplastic tissue.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Carbon-Nitrogen Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Biological Assay: A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.Mesocricetus: A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Biological Therapy: Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Lung Neoplasms: Tumors or cancer of the LUNG.Sarcoglycans: A family of transmembrane dystrophin-associated proteins that play a role in the membrane association of the DYSTROPHIN-ASSOCIATED PROTEIN COMPLEX.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Infant, Newborn: An infant during the first month after birth.Recurrence: The return of a sign, symptom, or disease after a remission.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Biological Warfare: Warfare involving the use of living organisms or their products as disease etiologic agents against people, animals, or plants.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Biological Processes: Biological activities and function of the whole organism in human, animal, microorgansims, and plants, and of the biosphere.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Programming Languages: Specific languages used to prepare computer programs.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Pest Control, Biological: Use of naturally-occuring or genetically-engineered organisms to reduce or eliminate populations of pests.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Phosphorous Acids: Inorganic derivatives of phosphorus trihydroxide (P(OH)3) and its tautomeric form dihydroxyphosphine oxide (HP=O(OH)2). Note that organic derivatives of phosphonic acids are listed under are ORGANOPHOSPHONATES.Interdisciplinary Studies: Programs of study which span the traditional boundaries of academic scholarship.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Protein Interaction Mapping: Methods for determining interaction between PROTEINS.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Kinetics: The rate dynamics in chemical or physical systems.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Pyruvate Carboxylase Deficiency Disease: An autosomal recessive metabolic disorder caused by absent or decreased PYRUVATE CARBOXYLASE activity, the enzyme that regulates gluconeogenesis, lipogenesis, and neurotransmitter synthesis. Clinical manifestations include lactic acidosis, seizures, respiratory distress, marked psychomotor delay, periodic HYPOGLYCEMIA, and hypotonia. The clinical course may be similar to LEIGH DISEASE. (From Am J Hum Genet 1998 Jun;62(6):1312-9)Sulfurtransferases: Enzymes which transfer sulfur atoms to various acceptor molecules. EC 2.8.1.Cilazapril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Hajdu-Cheney Syndrome: Rare, autosomal dominant syndrome characterized by ACRO-OSTEOLYSIS, generalized OSTEOPOROSIS, and skull deformations.Biological Clocks: The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.Integrin alpha4beta1: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.Methylmalonyl-CoA Decarboxylase: A carboxy-lyase that catalyzes the decarboxylation of (S)-2-Methyl-3-oxopropanoyl-CoA to propanoyl-CoA. In microorganisms the reaction can be coupled to the vectorial transport of SODIUM ions across the cytoplasmic membrane.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Biotinylation: Incorporation of biotinyl groups into molecules.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Autoanalysis: Method of analyzing chemicals using automation.Glycogen Synthase Kinase 3: A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Relative Biological Effectiveness: The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Artificial Intelligence: Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.Genetic Complementation Test: A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Carbon-Carbon Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.Biological Control Agents: Organisms, biological agents, or biologically-derived agents used strategically for their positive or adverse effect on the physiology and/or reproductive health of other organisms.Centrifugation: Process of using a rotating machine to generate centrifugal force to separate substances of different densities, remove moisture, or simulate gravitational effects. It employs a large motor-driven apparatus with a long arm, at the end of which human and animal subjects, biological specimens, or equipment can be revolved and rotated at various speeds to study gravitational effects. (From Websters, 10th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Phenylurea Compounds: Compounds that include the amino-N-phenylamide structure.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Oligopeptides: Peptides composed of between two and twelve amino acids.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Proteome: The protein complement of an organism coded for by its genome.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Databases, Nucleic Acid: Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Biological Warfare Agents: Living organisms or their toxic products that are used to cause disease or death of humans during WARFARE.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Biological Psychiatry: An interdisciplinary science concerned with studies of the biological bases of behavior - biochemical, genetic, physiological, and neurological - and applying these to the understanding and treatment of mental illness.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Toxins, Biological: Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.Biological Phenomena: Biological processes, properties, and characteristics of the whole organism in human, animal, microorganisms, and plants, and of the biosphere.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Biological Specimen Banks: Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Jurkat Cells: A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Semantics: The relationships between symbols and their meanings.Environmental Monitoring: The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Bacteriophage lambda: A temperate inducible phage and type species of the genus lambda-like viruses, in the family SIPHOVIRIDAE. Its natural host is E. coli K12. Its VIRION contains linear double-stranded DNA with single-stranded 12-base 5' sticky ends. The DNA circularizes on infection.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Some graduates have become top managers in bio-industry (Glaxosmithkline, Pfizer, etc.). The highest standard in biology ... Georgiy vinberg naroch biological station The scientific and research centre Georgiy Vinberg Naroch Biological Station is the ... The international collaboration is another strong feature of the Faculty. The Faculty routinely organises several key ... Note that the number of lecture and practical classes is significantly higher (sometimes by 10-15 times) in BSU's High ...
... in the synthesis of bio-inspired materials through processing methods and strategies that are characteristic of biological ... Fuel efficiency of the engine is also higher at high temperature, as shown by Carnot's theorem. In a conventional metallic ... The distinguishing feature of these methods is self-organization in the absence of any external forces.[citation needed] In ... Airframes: used as a high-stress, high-temp and lightweight bearing and structural component. Missile nose-cones: shielding the ...
Kimmerer Bio May Memorial Unitarian Universalist Society Podcast featuring Kimmerer reading a poem, February 11, 2007 ... Kimmerer is also a part of the United States Department of Agriculture's Higher Education Multicultural Scholars Program. The ... "Weaving Traditional Ecological Knowledge into Biological Education: A Call to Action", Oxford Journal, BioScience, Volume 52, ... 22 February 2007). "Another Frame of Mind". In Diverse: Issues in Higher Education. Tompkins, Joshua. (30 November 2004). "Moss ...
Biological micropatterning can be used for high-throughput single cell analysis, precise control of cellular microenvironment, ... as well as quantitative predictions of the biological environment of cells and biochemical reactions Microfluidic features can ... Bio-MEMS is an abbreviation for biomedical (or biological) microelectromechanical systems. Bio-MEMS have considerable overlap, ... high material and processing costs make silicon-based bio-MEMS less economically attractive. In vivo, silicon-based bio-MEMS ...
Among other features, the software supports read mapping of Sanger and high-throughput sequencing data, de novo assembly of ... CLC bio develops widely cited desktop and backend server software for analysis of biological data. While offering some open ... CLC bio's software is platform independent and can be used for Mac OS X, Windows, and Linux. CLC bio's analysis platform has ... CLC bio is no longer developing their own hardware-based products, but they are partnering with companies like SciEngines and ...
The Department of Biological Sciences' undergraduate BSc Bio Sciences is accredited by the Royal Society of Biology (RSB). IBSS ... In Dezember 2011, XJTLU was given the title of Most Influential Sino-Foreign Higher Education Institution in China at the ... Architecturally it contrasts the North Campus and features modern designs that complement the surrounding area. British ... "Review of Transnational Education in Mainland China". The Quality Assurance Agency for Higher Education. Retrieved 18 April ...
"Geoffrey Ling Bio on DARPA's Biological Technologies Office". DARPA. Retrieved 22 May 2014. Abdullah, Stephanie P. (June 13, ... Ling and his work have been featured twice on the TV show 60 Minutes, in 2009 and 2012. Ling is also an Adjunct Associate ... Geoffrey Ling, MD, PhD Geoffrey Ling Nifty Fifty - Bring a Top Scientist to your Middle or High School. ... Geoffrey Ling Bio". DARPA. Archived from the original on June 17, 2013. Retrieved June 3, 2013. "Geoffrey Ling, M.D., Ph.D., ...
Being able to degrade in biological environment lowers potential toxicity of polymers to a great extent and therefore, enhances ... At the same time, their reversible and dynamic nature make supramolecular polymers bio-degradable, which surmounts hard-to- ... Then a light-to-charge conversion system with faster photoinduced electron transfer and higher electron-transfer efficiency can ... Such formation manner endows supramolecular polymers with features, being more sensitive to external stimuli and able to render ...
... one of the highest Indian science awards, in 2005, for his contributions to biological sciences. He is also a recipient of the ... He has delivered a number of featured lectures and is one of the organizers of the Asian Forum for the Chromatin and Chromosome ... "Biographical Information". Jawaharlal Nehru Centre for Advanced Scientific Research. 2016. Retrieved October 20, 2016. " ... Kundu is a life member and a former vice president of the Society of Biological Chemists, India and is its incumbent president ...
Bio Assay Bio Assay tests the health of the creek's water using the indicator species Ceriodaphnia dubia which is highly ... Biological Assessment Biological Assessment monitors populations of macroinvertebrates in the creek bed. Large populations of ... permanent dead link] "Mira Loma High School Awards". 2004. Retrieved 2010-04-03. "Sacramento Bee - Mira Loma High wins ... Habitat The Habitat Study measures various physical features of the creek to provide a general description of its health. The ...
Bio-derived gasoline can be produced from DME via high-pressure catalytic condensation reaction. Bio-derived gasoline is ... The distinguishing feature is the technology involved in producing the intermediary product, rather than the ultimate off-take ... Chemical and biological processes that are currently used in other applications are being adapted for second-generation ... in that the higher alcohols have higher energy content. Also, when blending, the higher alcohols increase compatibility of ...
She received the Linnean Medal, the highest award of the Linnean Society, in 1990. She was also featured in a 1975 Vogue ... The Biographical Dictionary of Women in Science. 2. Marilyn Ogilvie and Joy Harvey (editors). New York and London: Routledge. p ... She was also Chairman of the School of Biological Studies (1972-3) and acting Head of Department (1948, 1969, 1970). During her ... 3 July 1906-4 October 1994: Elected F.R.S. 1971". Biographical Memoirs of Fellows of the Royal Society. 43: 445. doi:10.1098/ ...
"Biological aerosol detection with the tactical biological (TAC-BIO) detector". Optically Based Biological and Chemical ... Since these materials have a high index of refraction, design features of the devices such as special optical coatings and die ... the Edgewood Chemical Biological Center (ECBC) initiated the effort to create a biological detector named TAC-BIO. The program ... The TAC-BIO detector's response time was one minute from when it sensed a biological agent. It was also demonstrated that the ...
ISBN 978-0-323-29082-1. Ritchson, G. "BIO 554/754 - Ornithology: Avian respiration". Department of Biological Sciences, Eastern ... The highest expression of lung specific proteins are different surfactant proteins, such as SFTPA1, SFTPB and SFTPC, and napsin ... The left lung, unlike the right, does not have a middle lobe, though it does have a homologous feature, a projection of the ... Janis, C.M.; Keller, J.C. (2001). "Modes of ventilation in early tetrapods: Costal aspiration as a key feature of amniotes" ( ...
The resulting jacket was tiny, about 2 inches high and 1,4 inches wide and would just fit a mouse. To idealize the "victimless ... The victimless leather was featured in the exhibition "Design and the Elastic Mind" at The Museum of Modern Art in New York ... He has also worked with numerous other bio-medical laboratories in several different countries. Ionat Zurr was born in London, ... Zurr specialises in video production and biological and digital imaging. She works as an assistant professor and academic ...
Although higher magnifications are possible, it becomes increasingly difficult to maintain image clarity as the magnification ... Bright-field microscopy typically has low contrast with most biological samples, as few absorb light to a great extent. ... or polarizing filter on the light source to highlight features not visible under white light. The use of filters is especially ... BIOS Scientific Publishers (1998) Microbiology: Principles and Explorations by Jacquelyn G. Black, John Wiley & Sons, Inc. ( ...
Inspire with motives high For work and School. For students here and past Grant thankfulness, And endless rest at last. In 2001 ... George Skipper biography Retrieved 5 February 2014 Sexey's School. "Sexey's School - A Brief History". Archived from the ... that featured 12 pictures of boys and girls in seductive poses. Child protection groups criticised the calendar for its ... Vice President and Biological Secretary of the Royal Society Sir Harold Richard Scott, Commissioner of the Metropolitan Police ...
She attended Western High School in Baltimore where she participated in an accelerated program and graduated in three years. ... "Nancy Grace Roman Bio." NASA Science For Researchers. National Aeronautics and Space Administration, 29 Aug 2011. Web. 5 Nov ... In 2017, a "Women of NASA" LEGO set went on sale featuring (among other things) mini-figurines of Roman, Margaret Hamilton, Mae ... Biological, and Related Sciences. Ed. Andrea Kovacs Henderson. 30th ed. Vol. 6. Detroit: Gale, 2012. 339. Gale Virtual ...
The standing stock of grazers is higher than that of primary producers in the sea, the reverse of the situation on land. In the ... After the Earth Summit in Rio, 1992 and the adoption of the Convention on Biological Diversity, the term biodiversity has ... 2004). Marine organisms play crucial roles in many bio-geochemical processes that sustain the biosphere, and provide a variety ... on both global and regional scales come mainly from the terrestrial environment despite the marked distinctive features of ...
Biological fluid mechanics, or biofluid mechanics, is the study of both gas and liquid fluid flows in or around biological ... The next major bio-mechanic, Giovanni Alfonso Borelli, was the first to understand that "the levers of the musculature system ... Da Vinci tended to mimic some animal features in his machines. For example, he studied the flight of birds to find means by ... as these have strong connections to the organism's fitness and impose high mechanical demands. Animal locomotion, has many ...
Her findings of high suicide and psychosis rates on the island are closely related to these sketches and life stories. In a ... Nunivak biographies and genealogies". Science. New Series. 133: 1591. doi:10.1126/science.133.3464.1591. PMID 17781124. "Native ... With 18 autobiographical accounts and biological sketches from Nunivak Island in east Bering Sea, the book reveals the strains ... the Nunivak life histories present certain intriguing features that may help other field studies. Lantis contributed studies ...
First released in 2014, the "Bio-Trainer" is the worlds first all-natural, biological handmade sneaker. Produced from vegetable ... "FEIT PNTHA Hi Cork". Retrieved 9 December 2015. "FEIT Semi-Cordovan 8-Eye Lace Up Boot". ... According to an article published by The New York Times, the 420-square-foot space features "Large slabs of raw wood float ... "FEIT Bio Trainer". Retrieved 8 December 2015. "Sneaker of the Week: Feit Biotrainer". Retrieved 8 ...
He began playing the drums at age seven, and went on to play drums in high school jazz bands. Later on, he began performing at ... He was adopted at birth by two parents, who had previously lost three of their four biological children to a house fire. ... In advance of the album's release, he released a three-song extended play featuring "The Call" and two other songs from the ... "Matt Kennon biography". Allmusic. Retrieved 5 March 2010. "Digging Up Bones Xclusive: Interview With Matt Kennon". Randy Travis ...
She was born a 'love child' in Haight Ashbury and did not know of her biological father until she was seven. She grew up in New ... She is one of the "notable alumni" of The Mirman School for Gifted Children in Los Angeles, and of South Hampstead High School ... Aslan sees subtle detail that others don't...with the gently practiced air of a surgeon.". Madalyn has been featured on The ... Today Show, The Oprah Winfrey Show, PBS, Biography, BBC, CNN and other specials. Her horoscopes have been translated into seven ...
He also has a Ph.D in bio-chemistry from Duke University. The Johnson family produced Thomas (electrical engineer); Hazel ( ... Sugg created a school that consisted of the best features of the classical and vocational models of schooling that predominated ... ranging from geometry to calculus and the school had a storied tradition of winning local and state awards in the biological ... H.B. Sugg High School was a top K-12 educational institution founded in 1903, based at S. George St., Farmville, NC. It was ...
... models formulated in computational neuroscience are useful since they capture the essential features of the biological system ... Computational modeling of higher cognitive functions has only recently[when?] begun. Experimental data comes primarily from ... arXiv:q-bio/0512013. Bibcode:2006Natur.440.1007S. doi:10.1038/nature04701. PMC 1785327. PMID 16625187.. ... Biological neurons are connected to each other in a complex, recurrent fashion. These connections are, unlike most artificial ...
High Efficiency Ceramic Biological Rings In Filter Bag -Bio Balls -Final Stage 9 Watt Ultraviolet Sterilizer.. Features:. - ... High Efficiency Ceramic Biological Media. -3 Mechanical Fine Filter Pads. -Bio Ball. Im also getting a SR# protein skimmer for ... Mercs are listed as one of the higher escaping octos but this had not been my experience but you do need to keep them from ... It is your primary biological filter. The barnacles look ideal but you can even go with a small cluster with shells about the ...
C or higher in BIO 202; BIO 205 or BIO 207 Advisory Pre- or Corequisite: One of the following: BIO 320, BIO 321, BIO 351, or ... Major features of human social and sexual behavior are examined from a biological perspective. Insights from ethology, ... Corequisite: BIO 204 or BIO 311 or BIO 327 or BIO 486 or BIO 487 or BIO 488 or BIO 489 or departmental permission ... Prerequisite: BIO major with Neuroscience Specialization or departmental permission; C or higher in BIO 203; C or higher in BIO ...
Galvanically isolated differential biological amplifiers optimized for the measurement of a variety of biological signals and ... ADInstruments Bio Amps are galvanically isolated, high-performance differential biological potential amplifiers optimized to ... Features. *Full electrical isolation from power-line (mains) circuitry to guarantee subject safety ... The Bio Amp is a galvanically isolated, high-performance differential bio amplifier optimized for the measurement of a wide ...
Conventional approaches for ultrastructural high-resolution imaging of biological specimens induce profound changes in bio- ... In sheep aorta, for example, the tip may be located over features that appear to correspond to elastic lamellae. The ... b) High magnification bright field image of the inset in panel (a). The start (S) and end (E) points of a series of 5 μm AFM ... This tissue section AFM technique is capable of: i) resolving nm-microm scale features of intra- and extracellular structures ...
Methods of scientific inquiry and behavior of matter and energy in biological systems are explored. ... Biological Sciences Summer 2020 Courses. Featured Courses. BIO 223 - Vertebrate Zoology Accordion Closed. ... In this class students will learn about: how to have a high-altitude garden in an arid landscape, companion plantings, managing ... BIO 365W - Writing in the Biological Sciences. Provides students with practice in biological writing for both technical and non ...
Obtain reproducible results with Macro-Prep high S strong cation exchange resin. Exceptional capacity, resolution, and ... Key Features. *High capacity for biomolecules. *High resolution of complex biological mixtures ... Macro-Prep® High S Support Product Information Sheet, Rev A. Click to download [ Add to Cart (Free) ] Check Out ... Macro-Prep High S Support 156-0032 5 L, strong cation exchange chromatography media, for analytical, semi-preparative, and ...
series of Class II Biological Safety ... certification to the worlds highest safety ... the cabinets cannot be adjusted out ... Copyright © 2003-2012 Bio-Medicine. All rights reserved.. ABOUT , CONTACT US , DISCLAIMER , PRIVACY POLICY , TERMS AND ... Oven with circular clear acrylic chamber for ... HybriCycler Oven features microprocessor operation for precise ... the unit., ... Class II Biological Safety Cabinets provide ... comfort while incorporating the latest technology ... environment and product ...
Features and Benefits of Macro-Prep CM Resin. *High capacity for biomolecules ... High resolution of complex biological mixtures. *Rigid polymer matrix that allows high flow rates at moderate pressures ... If you are an educator at the high school or college level, visit our Education Discount Policy page to establish an education ... For more than 15 years, Bio-Rad has made science education a major priority. To support this effort, the company has ...
... circulating miRNA expression profile features higher accuracy exact than circulating mRNA expression profiles (Lu et al., 2005 ... Increasing evidence indicates that miRNA expression profiles measured in bio fluids may reflect biological processes in ... To identify the biomarkers with a high credibility during early pregnancy, DE miRNAs with , log2 (fold change), , 2 from ... For the first time, we applied several molecular biological techniques that allowed the detection of exosomal miRNAs in ...
Features,High,Yields,and,One-Step,,,Purification,biological,advanced biology technology,biology laboratory technology,biology ... The ESP system provides high-yield protein production in a eukaryot...Stratagenes EPS yeast protein expression and ... Copyright © 2003-2012 Bio-Medicine. All rights reserved.. ABOUT , CONTACT US , DISCLAIMER , PRIVACY POLICY , TERMS AND ... Yeast Protein Production System Features High Yields and One-Step,,,Purification. ... The ESP system provides high-yield ...
Biological micropatterning can be used for high-throughput single cell analysis, precise control of cellular microenvironment, ... as well as quantitative predictions of the biological environment of cells and biochemical reactions Microfluidic features can ... Bio-MEMS is an abbreviation for biomedical (or biological) microelectromechanical systems. Bio-MEMS have considerable overlap, ... high material and processing costs make silicon-based bio-MEMS less economically attractive. In vivo, silicon-based bio-MEMS ...
Among other features, the software supports read mapping of Sanger and high-throughput sequencing data, de novo assembly of ... CLC bio develops widely cited desktop and backend server software for analysis of biological data. While offering some open ... CLC bios software is platform independent and can be used for Mac OS X, Windows, and Linux. CLC bios analysis platform has ... CLC bio is no longer developing their own hardware-based products, but they are partnering with companies like SciEngines and ...
Some graduates have become top managers in bio-industry (Glaxosmithkline, Pfizer, etc.). The highest standard in biology ... Georgiy vinberg naroch biological station The scientific and research centre Georgiy Vinberg Naroch Biological Station is the ... The international collaboration is another strong feature of the Faculty. The Faculty routinely organises several key ... Note that the number of lecture and practical classes is significantly higher (sometimes by 10-15 times) in BSUs High ...
Higher-order feature maps using Neurogrid My thesis work demonstrates that we can generate an orientation map in a neuromorphic ... However, biological vision systems do not use just orientation to represent the visual world. They use a number of other maps ... also works as for extracting these higher-order features. Neurogrid is an ideal platform for modeling a cascade of pattern ... Exploring Map Formation with a Neuromorphic Model Bumps of activity, localized regions of high firing rates (hot colors), ...
The first one features spike characteristics, which correlate well with a biological neuron model. The second one is a ... The second one is a simplification of the first, designed to exhibit higher spiking frequencies, targeting large scale bio- ... The first one features spike characteristics, which correlate well with a biological neuron model. ... targeting large scale bio-inspired information processing applications. The most important feature of the fabricated circuits ...
High,Yield,Protein,Production,from,Pichia,pastoris,Yeast:,A,Protocol,for,Benchtop,Fermentation,biological,advanced biology ... High-level expression and efficient assembly of hepatitis B surface antigen in the methylotrophic yeast, Pichia pastoris. BIO / ... Yeast Protein Production System Features High Yields and One-Step Purification. 2. Efficient Cleavage of Fusion Proteins to ... High Yield Transcription for Every Application. 7. Maximize Viral RNA Yield from Biological Fluid. 8. Recover High Yields of ...
... in the synthesis of bio-inspired materials through processing methods and strategies that are characteristic of biological ... Fuel efficiency of the engine is also higher at high temperature, as shown by Carnots theorem. In a conventional metallic ... The distinguishing feature of these methods is self-organization in the absence of any external forces.[citation needed] In ... Airframes: used as a high-stress, high-temp and lightweight bearing and structural component. Missile nose-cones: shielding the ...
C or higher in BIO 202; BIO 205 or BIO 207 Advisory Pre- or Corequisite: One of the following: BIO 320, BIO 321, BIO 351, or ... Major features of human social and sexual behavior are examined from a biological perspective. Insights from ethology, ... Prerequisites: BIO 201, BIO 202, or BIO 203; BIO 205 or BIO 207; MAT 126 or higher ... Prerequisites: C or higher BIO 201; BIO 202; BIO 205 or BIO 207 ... Prerequisites: BIO 202; BIO 205 or BIO 207; MAT 126 or higher ...
The objective of this application note is to demonstrate that the ACQUITY UPLC H-Class Bio System with 2D Technology is a ... The heart-cut feature offered with the system is well suited for fractionation and desalting of challenging biological samples ... The Waters Protein-Pak Hi Res SP, 7 μm, 4.6 x 100 mm, strong cation exchange column (p/n 186004930) and ACQUITY UPLC Protein ... ACQUITY UPLCH-Class Bio System with 2D Technology featuring heart-cut technology. As described in part 1 of this three part ...
It covers the occurrence, biosynthesis and biological functions of these compound types in diverse organisms including bacteria ... This book describes the structural features and properties of important types of hydrocarbons and lipids and gives an overview ... It covers the occurrence, biosynthesis and biological functions of these compound types in diverse organisms including bacteria ... Discusses the environmental context both from a bio- as well as the geoscience perspective ...
High-Resolution Biological Dynamics in Your Lab Is a Reality Today. In-situ high-resolution dynamic studies with nanoscale ... FastScan Bios high-resolution and high-speed scanning provide the best available bio tool for the observation of molecules, ... FastScan Bios high-resolution and high-speed scanning provide the best available bio tool for the observation of molecules, ... Providing worlds fastest and highest resolution biological AFM imaging. *Measuring biological dynamics in real-time with ...
... features with high resolution and/or to identify correlations between structural features and conditions of interest with high ... Accordingly, certain geometric features of blood vessels may be used as biomarkers indicative of particular biological ... An abnormally high vascularity (measured as a higher than normal blood vessel number, density, length, or combination of the ... includes a method of analyzing geometric features of blood vessels and correlating one or more features with a biological ...
NYSE: A) today introduced the 1260 Infinity bio-inert quaternary liquid chromatography (LC) system designed to characterize and ... It features a completely inert, metal-free sample-flow path, and a stainless steel-free solvent delivery path to protect sample ... The system tolerates a very wide pH range from 1 to as high as 14. Agilent also offers a family of BioHPLC ion exchange and ... Agilent Technologies Launches Bio-Inert LC to Characterize Large Biomolecules, New Biological Entities. ...
... biological recognition unit and the transducers. The biological recognition unit deals with the given biological responses, bio ... Global High Temperature Exhaust Hoses Market Share, Overview, Scope, Trends, Key Players, Suppliers, Future and Forecast Until ... Parallax Media Ventures Announces B.C. - BACK TO CIVILIZATION, the first feature film adaptation of the Perennial Classic Comic ... They transform the signals produced with the contact of bio-elements with biological recognition unit into electric signal. ...
Our goal is the employment of the SERS technique for (bio)analytical devices. A main feature in order to achieve a versatile ... These devices feature significantly higher saturation power than conventional semiconductor optical amplifiers and can thus ... bio)chemical and biological analysis. Because the reproducibility of established SERS arrays (e. g. roughened metal electrodes ... High resolution SPRi is obtained by the surface plasmon lauching with a high numerical aperture objective lens. The advantages ...
  • The Faculty routinely organises several key international conferences, such as «Lake Ecosystems: Biological Processes, Anthropogenic Transformation, Quality of Water», «Xenobiotics and Living Systems», etc., usually involving several hundred participants. (
  • Finally, it addresses important aspects of their environmental chemistry and transfer processes between different compartments of bio- and geosphere. (
  • High-quality production processes ensure that every container contains pure, safe bacterial colonies, free of undesirable contaminants. (
  • The understanding of energy transfer processes in biological systems occurring among optical centres which exhibit in homogeneously broadened spectral bands is of paramount importance to determine time constants and spatial distribution of energy flow. (
  • The Division of Applied Science & Technology (Bioimaging) supports the development of biomedical imaging technologies to understand biological and disease processes for improving diagnostics, image-guided therapies, and human health. (
  • It has taken biological systems and physiological processes millions of years to evolve with the precise properties and functions they have today. (
  • By studying and mimicking complex biological structures and processes, engineers can now design materials and devices with novel features and enhanced properties to help solve problems in a wide variety of disciplines, from health care to small-scale electromechanical devices. (
  • By taking measurements faster and at higher resolutions, scientists can reduce run times and not repeat processes due to poor quality. (
  • About eighty graduates have received the 'Doctor of Sciences' degree (highest scientific degree, equivalent to Habilitation or old style UK D.Sc. (
  • seven hundreds graduates obtained the 'Candidate of Sciences' degree (equivalent to Ph.D.). A number of world-class researchers and outstanding managers of high education started their career in the Faculty. (
  • He also co-organized summer camps for high school students on the applications of computer science in biomedical sciences. (
  • The conference covers topics such as the latest techniques, methodologies and findings, spanning nano-to-macroscopic scales, and advances in fields such as nanotechnology, biological and clinical sciences, materials science, 3D manufacturing, and metallurgy. (
  • Industry biochemists and biophysicists received just a 3.6 percent increase over the same time and those in the academic biological sciences a mere 4.6 percent. (
  • Laura Lagomarsino, Director, Shirley C. Tucker Herbarium and Assistant Professor of Biological Sciences and colleagues from 25 institutions across the US received a $3.6 million grant from the National Science Foundation to image and digitize associated metadata for close to 1.2 million lichen and bryophyte specimens housed in their collections. (
  • she had each of them pick and interview a faculty member from Biological Sciences whose research they find interesting or exciting. (
  • This year, Amanda Hussein and Hailey Simpson from Biological Sciences are recognized among the 12. (
  • The development resulted from an unusual interdisciplinary collaboration between two groups of biologists-one from the Division of Biological Sciences and San Diego Center for Algae Biotechnology, which had been engineering algae to produce bio-products and biofuels, and another from the Center for Tropical Medicine and Emerging Infectious Diseases in the School of Medicine that is working to develop ways to diagnose, prevent and treat malaria. (
  • BUFFALO, N.Y. -- One of the nation's newest and most innovative biotechnology centers, the New York State Center of Excellence in Bioinformatics and Life Sciences, will open in June with a full schedule of scientific and community events, including a science and industry symposium featuring world renowned researchers in the fields of genomics, neuroscience and biomedical informatics. (
  • In medical and biological sciences, applications for light-based microscopy are both numerous and varied. (
  • Among other features, the software supports read mapping of Sanger and high-throughput sequencing data, de novo assembly of Sanger and high-throughput sequencing data, SNP detection on whole genomes of any size, detection of structural variations on whole genomes of any size, ChIP-seq analysis, RNA-Seq analysis, small RNA analysis and BLAST. (
  • CLC bio's software allows the user to analyze, visualize, and compare genomic, transcriptomic, and epigenomic data from all major high-throughput sequencing platforms such as Illumina, Life Technologies, Roche 454, Pacific Biosciences, and Complete Genomics. (
  • One of the critical issues is, of course, that measuring only a couple of hundred samples, control and case, would need to be done at a high enough throughput, and these measurements must be reproducible," says Ruedi Aebersold, a professor of systems biology at the Swiss Federal Institute of Technology in Zurich. (
  • Recent advances in high-throughput technologies yielded an explosion of the amount of -omics data available to scientists for many different research topics. (
  • Advancements in lab-on-a-chip technology promise to revolutionize both research and medicine through lower costs, better sensitivity, portability, and higher throughput. (
  • In Science this week: approach to measure microRNA targeting efficiency, strategy to conduct high-throughput chemical screens at single-cell resolution, and more. (
  • Lensfree On-Chip Fluorescence Microscopy for High-throughput Imaging of Bio-Chips. (
  • CompacT SelecT - Automated cell culture system for high quality cells and assay ready plates suitable for small & medium throughput laboratories. (
  • The Intellicyt® iQue Platform is an advanced flow cytometry technology featuring high throughput multiplex capability and fast acquisition speed, which is tailored for high content screening and biomarker profiling. (
  • The shortcomings of current biomass pretreatment and conversion options are described as a backdrop for BESC's research programs to develop a one-pot process (combining biomass deconstruction and fuel synthesis in one reactor vessel), a capability to conduct high throughput screening of potential biomass samples, and the opportunity to discover microbes with new enzymes in locations such as hot pools in Yellowstone. (
  • Stem cells are fuelling the development of many new disease models and with high levels of translation to human biology and disease these phenotypic assays are increasingly being used in early toxicity testing. (
  • Phenotypic assays share a common feature, ie there must be high confidence in their translation to human biology and disease. (
  • The search for innovative therapies via candidate drug screening requires a funnel of biological assays to characterize drug signatures and move candidates into clinical trials. (
  • Bio-Rad Benchmark has a Peltier thermal control and records both endpoint and kinetics assays (with various plate configurations including 96 and 384 wells). (
  • Bio-MEMS have considerable overlap, and is sometimes considered synonymous, with lab-on-a-chip (LOC) and micro total analysis systems (μTAS). (
  • Similarly, micro total analysis systems may not have biological applications in mind, and are usually dedicated to chemical analysis. (
  • However, biological vision systems do not use just orientation to represent the visual world. (
  • Bio Tree Systems, Inc. (
  • A remarkable feature of the implemented method is that it remains efficient for challenging condensed phase systems even if large accurate basis sets are used. (
  • In the case of non-biological systems, we present detailed protocols relating to quantifying the heat liberated by highly-concentrated NP colloids. (
  • For biological systems, in the case of in vitro experiments, we describe the techniques and conditions which must be adhered to in order to effectively expose cancer cells to RF energy without bulk media heating artifacts significantly obscuring the data. (
  • Bio-inspired algorithms and techniques feature fault-tolerant and self-adaptive behaviours that help to boost the autonomic nature of distributed systems (Germain-Renaud and Rana 2009 ), and are proving effective to solve highly parallel and distributed problems. (
  • These techniques sometimes rely on the operations of agents, whose behaviour is inspired by biological systems, including ant colonies, bird flocks, honey bees, bacteria, and many more. (
  • Bio-inspired algorithms and systems are applied to hard and large problems in a variety of areas. (
  • The authors presented their preliminary works in the 3rd Workshop on Bio-Inspired and Self-* Algorithms for Distributed Systems, BADS 2011 (Folino et al. (
  • The paper "The grid, the load and the gradient: a bio-inspired approach to load balancing", by Amos Brocco, presents a fully distributed load balancing mechanism, called Ozmos, which aims at increasing the efficiency of distributed computing systems through peer-to-peer interaction between nodes. (
  • Imaging systems and algorithms to analyze biological samples in real-time using mobile phone microscopy. (
  • Sparse coding is also believed to be a key mechanism by which biological neural systems can efficiently process a large amount of complex sensory data while consuming very little power. (
  • In looking at this, we should note too that in state space approaches to control systems, matrix elements can be in effect complex domain transfer functions, giving a higher dimension of power to matrix based processing. (
  • Nanowerk News ) Park Systems, a leading manufacturer of atomic force microscopy (AFM) products, announces PinPoint™ Nanomechanical Mode a new application designed to measure and map mechanical properties in materials and biological cells simultaneously and in real-time from high speed force-distance (F-d) curves with accurate control of both contact force and time. (
  • The Division of Discovery Science & Technology (Bioengineering) supports the development of mathematical and computational methods, bio-transducer technologies, and engineered systems to interface with biology to open a new paradigm of biomedical intervention for human health. (
  • O ne of the key features of current phenotypic approaches is the biological relevance of the assay systems deployed and in this respect the commercial availability of unlimited quantities of pure human cell types, particularly those derived from induced pluripotent stem cells, is having an impact. (
  • P henotypic drug discovery has also been powered by recent advances of high content imaging systems, facilitating the rapid analysis of increasingly complex multi-parametric measurements of cellular phenotypes or biomarkers. (
  • One of the key features of current phenotypic approaches is the biological relevance of the assay systems deployed and in this respect the commercial availability of unlimited quantities of pure human cell types, particularly those derived from induced pluripotent stem cells, is having a major impact. (
  • To the best of our knowledge, as the first study in NGS network marker discovery, our work not only bridges transcriptomics and systems biology, but also contributes to clinical diagnostics, large scale biological data mining, and information fusion. (
  • It is seen that people who are involved in biological research buy varieties systems that helps them to do their research very well. (
  • If you are also looking to buy quality gel imaging systems then you must purchase them from Bio Olympics Ltd (bioolympics). (
  • The self-organization of functional proteins directly onto solid materials is attractive to a wide range of biomaterials and systems that need to accommodate a biological recognition element. (
  • In such systems, inorganic binding peptides may be an essential component due to their high affinity and selective binding features onto different types of solid surfaces. (
  • Because the dioxin concentrations in these samples areextremely low, ultra high sensitivity is one of the critical features required for analytical systems. (
  • biological systems to affect these behaviors? (
  • The Center for Advanced Biomaterials for [email protected] develops materials and technologies to engineer bio-logically inspired platforms and systems for applications in the biomedical sector. (
  • This includes operation of digital imaging systems offered by CRAIC Technologies including those for high resolution color, ultraviolet and near infrared imaging. (
  • Nobel Laureate Paul Greengard, Ph.D., winner of the 2000 Noble Prize in Physiology or Medicine and professor of molecular and cellular neuroscience at The Rockefeller University, will be among the distinguished speakers at the "Frontiers in Biological Systems" symposium to be held June 13-15 in the Center of Excellence and the Hyatt Regency in Buffalo. (
  • Engineers have only recently developed an appreciation of the sophistication of biological systems, and they are looking to them for inspiration in the rational design of materials and systems. (
  • Philips Healthcare of Andover, Mass., saw this as an opportunity to introduce the PowerSave feature in its Achieva and Panorama lines of MRI systems, to reduce energy consumption by up to 50 percent. (
  • While offering some open source algorithms with their tools, CLC bio have their own implementations of several popular applications, which have been accelerated using SIMD technology. (
  • Early on, the company presented own-developed high-performance computing solutions, focusing on accelerating open source algorithms such as HMMER, Smith-Waterman and ClustalW, using FPGA technology. (
  • Machine learning methods, and particularly feature selection algorithms, have proven very effective over the years at identifying small but relevant subsets of variables from a variety of application domains, including -omics data. (
  • We compare RGIFE against five well-known feature selection algorithms using both synthetic and real (cancer-related transcriptomics) datasets. (
  • Bio-inspired algorithms have been successfully used as alternative and/or superior solutions to the problems that traditional algorithms cannot solve satisfactorily. (
  • Here, we report the experimental implementation of sparse coding algorithms in a bio-inspired approach using a 32 × 32 crossbar array of analog memristors. (
  • When coupled to a mass spectrometer, the ACQUITY UPLC H-Class Bio System with 2D Technology renders an efficient method for combining complementary orthogonal techniques employed in the monitoring of C-terminal lysine variants in therapeutic monoclonal antibodies without compromising productivity. (
  • The objective of this application note is to demonstrate that the ACQUITY UPLC H-Class Bio System with 2D Technology is a viable option for interfacing IEX to electrospray ionization (ESI)-MS. A therapeutic monoclonal antibody, infliximab, was used as a model protein to evaluate the functionality. (
  • BOSTON, Mass., HPLC 2010, Agilent Technologies Inc. ( NYSE: A ) today introduced the 1260 Infinity bio-inert quaternary liquid chromatography (LC) system designed to characterize and confirm large biomolecules, especially new biological entities (NBEs) and therapeutic monoclonal antibodies. (
  • Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. (
  • In addition, patient stratification is critical in bio-therapeutic drug discovery, including chimeric antigen receptor T (CAR-T) cell therapy, to stratify patients based on biomarkers. (
  • Agilent also offers a family of BioHPLC ion exchange and size exclusion columns designed for these specific types of analyses, contributing to the robust, reproducible high-resolution performance. (
  • At the time, the application of MEMS to biology was limited because this technology was optimized for silicon or glass wafers and used solvent-based photoresists that were not compatible with biological material. (
  • The highest standard in biology teaching is maintained due to the strong linkage between educational process and the scientific research in the Faculty. (
  • The Faculty also organises students' research conferences and paper contests, Annual Belarusian Biology Olympiad for High Education Students. (
  • The CSF hosts high-performance computing for biology and national security research. (
  • Therefore, the solution to the obesity epidemic to bridge the factors that influence obesity-related behav- lies in policies and interventions that alter those contextu- iors at the macro level (typical y policies that shape and al features, taking individual biology and preferences into govern the food, physical, social, and economic environ- account. (
  • Nanoparticles for luminescent probes in bio-imaging have recently attracted widespread interest in biology and medicine. (
  • Recently, with the increased biological interest in the evolution of animal social behavior ("sociobiology"), there has been renewed interest by philosophers in the possibility of fruitful connections between biology and morality. (
  • The connecting thread among these talks is the diverse role biology plays in contemporary engineering, as bio-derived or bio-inspired technologies are pivotal to novel engineering solutions in a number of fields. (
  • With several biological drugs expected to lose patents by 2020, this segment is expected to experience an annual growth rate of more than 30.0% by 2020. (
  • Conventional approaches for ultrastructural high-resolution imaging of biological specimens induce profound changes in bio-molecular structures. (
  • By combining tissue cryo-sectioning with non-destructive atomic force microscopy (AFM) imaging we have developed a methodology that may be applied by the non-specialist to both preserve and visualize bio-molecular structures (in particular extracellular matrix assemblies) in situ. (
  • Biomagnetic technologies rely on the ability of biological substances to form supra-molecular structures when they are mixed with magnetic nanoparticles. (
  • Our results can be easily applied to any kind of efficient interacting chromophore pairs embedded in inhomogeneous scattering structures such as biological tissues. (
  • Carbohydrate-active enzymes are the biological catalysts that synthesize and break down the multitude of complex carbohydrate structures found in nature. (
  • Ultrastructure: Top-class microscopes enable to investigate material morphology and structures with ultra-high resolution. (
  • The yeast S. pombe is a unicellular eukaryotic organism, with properties that closely resemble higher eukaryotic organisms regarding chromosome structure and function, cell cycle control and RNA splicing. (
  • These rocky buildups have a patchy distribution and a variety of benthic calcareous constituents contribute to their growth, including bryozoans, mollusks, serpulid polychaetes, scleractinians and calcareous algae, the latter acting as the main bio-concretionning organisms [ref. 7 and references therein]. (
  • For over 80 years, Carolina has been providing the highest-quality living organisms and cultures available. (
  • It enables features such as individual neurons to be visually isolated and viewed in multiple orientations using computer graphics. (
  • different types of biological spiking neurons. (
  • They do show features exhibited to one degree or another and in differing combinations in real neurons. (
  • In other words, it really doesn't make any sense to try to categorize Izhikevich types to specific brain areas or functions because biological neurons are not divided specifically into those types. (
  • It is useful to see what kinds of unanticipated 'behavior' is produced by computational circuits composed of Izhikevich types and it is useful to consider what kinds of Izhikevich categories of behavior are exhibited by particular biological neurons and how those particular aspects of their behavior contribute to their function. (
  • Stratagene's EPS yeast protein expression and purification system llll provides novel opportunities for rapid, inexpensive and high-yield production of proteins in a eukaryotic organism. (
  • This system retains many eukaryotic posttranslational modifications of proteins that can be critical for the biological activity of expressed proteins. (
  • This type of experiments allows the analysis of the relationships and the properties of many biological entities (e.g. gene, proteins, etc.) at once. (
  • Around the same time, on other side of the globe, muscle physiologist Karyn Esser, then at the University of Illinois at Chicago, also stumbled upon a surprising discovery: genes encoding essential elements of biological clocks being expressed in rat muscle tissue. (
  • This automated tool creates high-resolution three-dimensional images from biological tissue. (
  • He hypothesized that if boron could be selectively concentrated in a tumoral tissue and then exposed to a neutrons beam, a higher radiation dose to the tumor relative to surrounding normal cells would result. (
  • With this new contrast agent the aim is to obtain higher resolution, tissue specific images and cell- and molecular imaging. (
  • Guided, smart, targeting nanoparticulate magnetic resonance imaging (MRI) contrast agents inducing high MRI signal will be valuable tools for future tissue specific imaging and investigation of molecular and cellular events. (
  • Emission occurs in a spectral window of low absorption, which is attractive for biological labeling due to greater penetration of light in surrounding tissue. (
  • Macro-Prep High S strong cation exchange support meets the demands of analytical, semipreparative, and process-scale applications. (
  • This book describes the structural features and properties of important types of hydrocarbons and lipids and gives an overview of their analytical characterization in biological and environmental matrices. (
  • The new Agilent bio-inert LC system can accommodate both bioanalysis and bio-purification tasks, offering analytical flow rates and fraction collection as high as 10 ml/min. (
  • The Biosensors are the medical devices that provide analytical information with the help of the given biological responses available in micro-volumes. (
  • A high dimensional data set with enormous data points presents analytical challenges to unravel the complex biochemistry needed to provide meaningful biological signatures of drug candidates and samples from potential patients for insight-driven decision making. (
  • For analytical and bioanalytical chemical analyses, there are additional instruments such as a Bio-Rad Benchmark UV-Vis plate reader and BioTek Synergy MX fluorescence plate reader which utilize standard 96 well plates for analysis. (
  • Thirdly, DARPA of the US Department of Defense supported a series of microfluidic research programs in the 1990s after realizing there was a need to develop field-deployable microsystems for the detection of chemical and biological agents that were potential military and terrorist threats. (
  • The standard detector and the 600-bar power range combine to provide the lowest detection limits and highest resolution per time for any bio-inert LC-based bioseparation system, from low-pressure methods up through small-particle, high-pressure column technology. (
  • 0.9935), low-detection limit (?0.42 nM, SNR?3), and higher sensitivity (?74.3 µA µM(-1) cm(-2)), lowest-small sample volume (50.0 ?L), good stability, and reproducibility. (
  • To the best of our knowledge, this is the first statement with a very high sensitivity, low-detection limit, and low-sample volumes are required for cholesterol biosensor using Au/TGA/ChOx-chips assembly. (
  • The resulting high signal-to-noise ratio makes for very responsive detection. (
  • We herein report combined heavy metal probes that will enable detection and spatially resolved chemical analysis of biological samples. (
  • We recently demonstrated that functionalized heavy atom carbonyl cluster labeled reagents can be used for bio-sensing/bio-recognition using Fourier transform infrared (FTIR) spectroscopy, albeit with lower detection sensitivities than competing technologies [ 6 ]. (
  • Addressing these challenges involves mimicking and exploiting biological recognition and/or function with detection at high fidelity. (
  • In vivo MR imaging at 7T offers many advantages, including increased signal-to-noise ratio, higher spatial res. (
  • We demonstrate that even in the case of spectral overlap between donor and acceptor (monomer and dimer) emissions, this kind of spectroscopy may resolve not only the spectral features of the system but also provide a high speed picture of the energy transfer and excited state relaxation of the involved optical probes. (
  • A nano drop spectrometer makes spectral experiments on small volume biological/biochemical samples easily accomplished. (
  • One of the major research field in bioinformatics involves the discovery of driving factors, biomarkers, from disease-related datasets where the samples belong to different categories representing different biological or clinical conditions (e.g. healthy vs. disease affected patients). (
  • The goal is to identify a subset of features (biomarkers), commonly called signature , that can build a model able to discriminate the category (label) of the samples and eventually provide new biological or clinical insights. (
  • Importantly, effective longitudinal water proton relaxivities of these nanoparticles are higher than those of positive contrast agents based on gadolinium complexes such as Gd-DOTA, which are currently used clinically for clinical magnetic resonance imaging (MRI). (
  • The challenges to bio-inspired engineering are many, but the benefits will be tremendous in determining mechanisms of disease, drug candidates, and clinical molecular diagnostics. (
  • SICM's in-liquid imaging capability allows biologists to observe morphology of biological features as never before possible with scanning electron microscopy (SEM). (
  • By adjusting contact force and time, PinPoint™ Nanomechanical imaging can reveal embedded details of material components on and under the sample surface, enabling a distribution map of material components in a high resolution of nanometer scale and analysis comparing with a surface morphology directly. (
  • The process is done using Park Systems's unique methodology, while measuring a morphology of the sample, the XY scanner stops at each data acquisition point for taking the high speed force-distance curves with well defined control of contact force(or distance) and contact time between the tip and the sample. (
  • This course will guide students through the morphology of amphipods focusing on features used in identification at the family level. (
  • STED and multiphoton confocal microscopes are specifically used to biological specimens with unparalleled spatial and temporal resolution, even in living conditions. (
  • Biosensors are advanced and innovative technological medical devices that are used in ultra-microanalysis providing high level output, accuracy, specification, sensitivity within reasonable rates. (
  • CLC bio maintains a scientific focus by initializing and participating in various research projects around the world, including multiple projects funded by grants. (
  • The Faculty also owes a research base on Naroch Lake (large lake in the Northern Belarus), which is called «Vinberg's Naroch Biological Station» and used both for teaching and research purposes. (
  • In-situ high-resolution dynamic studies with nanoscale resolution are a reality for a rapidly evolving branch of biological research. (
  • He is also a Janelia Farm Scientist, spending one month per year at the Janelia Farm Research Campus, part of the Howard Hughes Medical Institute, in Virginia, where scientists are freed from grant application writing, administration and teaching, and instead encouraged to pursue high-risk ventures. (
  • The combined Biological and Computational Science buildings support the Department of Energy's environmental, national security and fundamental science research. (
  • The lobby also houses educational materials including showcasing ongoing research and displaying an interactive screen explaining the building's sustainable features. (
  • This new feature is compatible with Park AFM products Park NX10, Park NX20 and Park NX-Bio used world-wide for unparalleled accuracy in AFM imaging for industry and research. (
  • A robot baby was used to determine how much biological material crawling infants stir up from carpets by a research team led by Brandon E. Boor, an assistant professor at Purdue University. (
  • The students were instructed to ask questions related to a recent publication, an ongoing research project, or other topics (biography, career path) of interest to the interviewer. (
  • After a long research, adding some new features, this item was upgraded to UV illuminator. (
  • Pel-Freez Biologicals produces high quality raw materials and intermediates for biological research and diagnostic manufacturing. (
  • 2). Evidence in behavioral economics suggests that these a climate of training, funding, and academic and institu- powerful biological and contextual forces often place eat- tional support for obesity research that wil offer sustain- ing and exercise behavior beyond an individual's rational able solutions to the obesity problem. (
  • The control and the guidance of the interactions between synthetic materials and biological entities is the leitmotif of the research activities. (
  • Mayfield is co-director of the Center for Food & Fuel for the 21st Century, a new Organized Research Unit that sponsored the three-day symposium and will be bringing together researchers from across the campus to develop renewable ways of improving the nation's food, fuel, pharmaceutical and other bio-based industries. (
  • The December 8, 2008 edition of C&EN provides extensive coverage of DOE's bioenergy research. (
  • In addition, Research and Markets were extremely helpful and willing to provide a few extra custom features to make the report even more useful. (
  • Extensive analysis of the PepCVAE-generated sequences reveals superior performance of our model in comparison to a plain VAE, as PepCVAE generates novel AMP sequences with higher long-range diversity, while being closer to the training distribution of biological peptides. (
  • Despite remarkable recent progress in linear-scaling density function theory, the computational cost of existing methods remains too high for routine ab initio molecular dynamics (AIMD) simulations. (
  • Physical organic chemistry uses physical methods to study the structure of organic molecules as well as the interrelationships between molecular structure and chemical, physical and biological properties of organic compounds. (
  • The Laboratory of Physical Organic Chemistry at IOS features state-of-the-art equipment and high level expertise in nuclear magnetic resonance (NMR), X-ray diffraction, masspectrometry, electrochemistry, electron paramagnetic resonance (EPR), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) to perform studies of the molecular structure and its relationships to chemical reactivity, (bio)physical properties and biological activity of organic compounds. (
  • There is an increasing need in the military sector for high-strength, robust materials which have the capability to transmit light around the visible (0.4-0.7 micrometers) and mid-infrared (1-5 micrometers) regions of the spectrum. (
  • Compared with the network markers from other omics data (e.g. microarray), the disease network markers demonstrated high diagnostic accuracy and reproducibility, in addition to its effective gene marker inference capability. (
  • Lifegard Aquatic's product line features filtration units, ultraviolet (UV) sterilizers, pumps of every conceivable size and performance, automatic fish feeders, digital thermometers, filter media, Fittings, valves and other support equipment required for maintaining indoor or outdoor installations. (
  • Combined UV and biological filtration for crystal clear, purified water. (
  • Municipal Wastewater Treatment is experiencing tremendous change with effluent discharge permits requiring higher levels of advanced treatment, including tertiary filtration. (
  • The Little Giant 566881 PBF-2000 Pressurized Biological Filter uses two different types of media to filter the water in small ponds. (
  • This Little Giant 566881 PBF-2000 Pressurized Biological Filter can be installed above or underground. (
  • The Little Giant 566881 PBF-2000 Pressurized Biological Filter is covered by a limited warranty of 36 months from purchase date. (
  • We're glad that you are interested in our Little Giant 566881 PBF-2000 pressurized biological filter. (
  • For chemical product characterization, there are two FT-IRs, a Bruker multi-nuclear high field NMR ( 1 H at 400 MHz), two Agilent 8453 UV-Vis diode array spectrometers, and a Perkin-Elmer LS50B scanning fluorimeter. (
  • This paper will show how two of the techniques, Structured Illumination Microscopy (SIM) and PhotoActivated Localization Microscopy (PALM), complement each other in imaging of biological samples beyond the resolution of classical widefield fluorescence microscopy. (
  • As a reference the properties of two well known standard imaging techniques in this field, confocal Laser Scanning Microscopy (LSM) and Total Internal Reflection (TIRF) microscopy, are compared to the properties of the two high resolution techniques. (
  • We introduce a new non-labeling high resolution microscopy method for cellular imaging. (
  • X-ray microscopy ( XRM ) and computed tomography ( CT ) equipment from Rigaku enable nondestructive analysis of large samples at high resolution. (
  • X-ray microscopy is suited to a range of materials, from low-density substances such as biological samples to high-density materials such as ceramics and steels. (
  • Scanning ion conductance microscopy (SICM) is a new nanoscalemicroscopy specially developed for biological object observation in liquid environments. (
  • The nanoscale high-resolution of SICM enables visualizing the details of biologically important features of a size not observable with conventional optical microscopy. (
  • We have commercialized combined fluorescent and heavy metal probes that enable collection of complimentary sets of data, from fluorescence and electron microscopy, for correlative microscopic studies of biological targets at different spatial resolutions . (
  • We used state-of-the-art aerosol instrumentation to track the biological particles floating in the air around the infant in real-time, second by second. (
  • Most bacterial cells, fungal spores, and pollen particles are fluorescent, so they can be reliably distinguished from non-biological material in the air," Boor says. (
  • The researchers found that a concentrated cloud of resuspended particles forms around the Pig-Pen wannabes, and that the concentrations around them can be as much as 20 times greater than the levels of material higher in the room. (
  • For an adult, a significant portion of the biological particles are removed in the upper respiratory system, in the nostrils and throat. (
  • Recently, we and others reported construction of electron density maps of tetra-iridium (Ir 4 ) cluster labeled virus capsids and ribosome particles by cryo-EM and X-ray crystallography respectively at medium to high resolution [ 1 , 4 ]. (
  • Nanodiamonds are synthesized by detonation of carbon-containing explosives (called detonation nanodiamonds, as shown in Fig. 1) 5 or by fragmentation of micron-sized diamond particles produced by phase transformation of carbon precursors under high pressure and high temperature. (
  • Vacancies can be produced by irradiating the diamond with high-energy particles. (
  • Part 1 of this three-part application series demonstrated that the Waters ACQUITY UPLC H-Class Bio System with 2D Technology offers an efficient solution for increasing productivity in the fractionation and desalting of charge variants in complex biotherapeutic samples. (
  • For 3D and 4D imaging of micro-scale morphologies, Rigaku offers the Rigaku CT Lab HX high-performance benchtop X-ray micro CT system, a compact yet powerful micro CT system that can provide three-dimensional X-ray images of a wide variety of samples. (
  • In addition to conventional environ-mental samples such as fly ash and exhaust gas, biological and water samples such as blood, breastmilk, and tap water are being analyzed. (
  • Recognizing the initial steps of bio-concretionned rocky buildups developing in a loose silicilastic sedimentary context has been always hampered by the difficulty of getting samples of diagnostic value, especially for the recurrent conditions of poor visibility due to the high water turbidity encountered by divers. (
  • Nanodrop UV-Vis instrument allows studying very small samples with high precision. (
  • It features a completely inert, metal-free sample-flow path, and a stainless steel-free solvent delivery path to protect sample integrity and to minimize unspecific surface interaction and corrosion of the instrument. (
  • Structural features of the ND surface include a layer of functional groups (oxygen atoms and hydrocarbon chains are shown in red and green, correspondingly) and patches of graphitic sp 2 carbon (shown in black). (
  • Further investigation highlighted marked erosion along the northern Adriatic shelf suggesting that the bio-concretions likely grew on structural relicts of exhumed sedimentary horizons e.g. ref. 13 . (
  • However, it is the more recent class of Spiking Neural Networks (SNNs), often referred to as the third generation of neural networks, that are known to be bio-realistic and more computationally potent compared with their predecessors ( Maass, 1997 ). (
  • The article explains challenges to the biological production of biofuels, especially the recalcitrance of lignocellulosic material to degradation. (
  • An international study on how much and the types of biological material babies stir up by crawling on carpet was led by Purdue University's Brandon Boor. (
  • High-resolution image of DNA Lambda digest DNA was adsorbed on a mica surface and imaged using TappingMode under aqueous conditions. (
  • High resolution SPRi is obtained by the surface plasmon lauching with a high numerical aperture objective lens. (
  • The Rigaku nano3DX X-ray microscope images an entire sample from multiple angles, using a high-powered rotating anode X-ray source and a high-resolution CCD imager, enabling reconstruction of a 3D image at 0.27 µm resolution. (
  • Computed tomography reveals, at high-speed, the high-resolution, three-dimensional structure of an object by means of computer-processed combinations of numerous X-ray images taken from different angles. (
  • Park's AFM provides highest data accuracy at nanoscale resolution, superior productivity, and lowest operating cost thanks to its unique technology and innovative engineering. (
  • According to Mary, "The NIJ GRF has enabled me to push at the technological boundaries of my field, moving from traditional histology to cutting-edge, high-resolution micro-computed tomography. (
  • 2 Additionally, optically detectable spin properties of selected color centers - particularly the nitrogen vacancy center - have stimulated developments in high-resolution magnetometers, atomic-sized sensors for electric fields, and quantum measurements of temperature gradients within living cells. (
  • a ) A high-resolution transmission electron microscope image of a ~6-nm detonation nanodiamond (ND) particle, demonstrating the perfect crystallographic structure of the diamond nanoparticle core. (
  • High-resolution geophysical surveys and underwater SCUBA diving reconnaissance revealed meandering shaped morphologies underneath bio-concretionned rocky buildups. (
  • The antimicrobial efficacy, shown as a result of high-yield design of AgNPs, may inadvertently cause variation in host cells biological responses. (
  • Fluval Biological Enhancer provides consistent results thanks to our unique and proprietary bio-floc technology that ensures product stability, efficacy and shelf life. (
  • I will present evidence that we and others have accumulated in recent years demonstrating that BZT derivatives show psychopharmacological features consistent with those of an ideal replacement or substitute treatment. (
  • The military requirements of World War II encouraged developments, which created a need for high-performance materials and helped speed the development of ceramic science and engineering. (
  • Everything is designed not only with energy savings and sustainable materials in mind, but also with the comfort of the occupants.The wide variety of sustainable design features employed throughout the project means that every occupant will see the benefit of ecological design in their daily routine. (
  • Careful selection of raw materials ensures a high. (
  • These Ir 4 clusters contain carbonyl ligands that exhibit extremely intense infrared (IR) absorptions in the region where most of the biological materials do not absorb (Fig. 1b). (
  • The intelligent, automated self cleaning mechanism uses high pressure water jets to periodically cleanse the stainless steel filter sieves, minimising the need to service the filter module. (
  • Professor Sergey A. Usanov (graduated in 1973) is a Head of the Institute of Bio-organic Chemistry of the NASB. (
  • the authors observe that bio-inspired self-organizing mechanisms have been applied to different domains, achieving results beyond traditional approaches, and intend to respond to the needs for an ensemble overview of such mechanisms in terms of modular and reusable design patterns organized into different layers. (