The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.
An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.
Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.
Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.
Geological formations consisting of underground enclosures with access from the surface.
Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
The time period of daily exposure that an organism receives from daylight or artificial light. It is believed that photoperiodic responses may affect the control of energy balance and thermoregulation.
A broad category of proteins that regulate the CIRCADIAN RHYTHM of an organism. Included here are proteins that transmit intracellular and intercellular signals in a chronological manner along with proteins that sense light and time-dependent changes in the environment such as the PHOTOPERIOD.
A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
The absence of light.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).
A species of ascomycetous fungi of the family Sordariaceae, order SORDARIALES, much used in biochemical, genetic, and physiologic studies.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Elements of limited time intervals, contributing to particular results or situations.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
Collections of systematically acquired and organized information resources, and usually providing assistance to users. (ERIC Thesaurus, http://www.eric.ed.gov/ accessed 2/1/2008)
The science of breeding, feeding and care of domestic animals; includes housing and nutrition.
The normal length of time of an organism's life.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
A chronobiologic disorder resulting from rapid travel across a number of time zones, characterized by insomnia or hypersomnolence, fatigue, behavioral symptoms, headaches, and gastrointestinal disturbances. (From Cooper, Sleep, 1994, pp593-8)
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
A genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several lodopodia, one of which is dominant at a given time. Reproduction occurs asexually by binary fission.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

Characterization of K+ currents underlying pacemaker potentials of fish gonadotropin-releasing hormone cells. (1/2760)

Endogenous pacemaker activities are important for the putative neuromodulator functions of the gonadotropin-releasing hormone (GnRH)-immunoreactive terminal nerve (TN) cells. We analyzed several types of voltage-dependent K+ currents to investigate the ionic mechanisms underlying the repolarizing phase of pacemaker potentials of TN-GnRH cells by using the whole brain in vitro preparation of fish (dwarf gourami, Colisa lalia). TN-GnRH cells have at least four types of voltage-dependent K+ currents: 1) 4-aminopyridine (4AP)-sensitive K+ current, 2) tetraethylammonium (TEA)-sensitive K+ current, and 3) and 4) two types of TEA- and 4AP-resistant K+ currents. A transient, low-threshold K+ current, which was 4AP sensitive and showed significant steady-state inactivation in the physiological membrane potential range (-40 to -60 mV), was evoked from a holding potential of -100 mV. This current thus cannot contribute to the repolarizing phase of pacemaker potentials. TEA-sensitive K+ current evoked from a holding potential of -100 mV was slowly activating, long lasting, and showed comparatively low threshold of activation. This current was only partially inactivated at steady state of -60 to -40 mV, which is equivalent to the resting membrane potential. TEA- and 4AP-resistant sustained K+ currents were evoked from a holding potential of -100 mV and were suggested to consist of two types, based on the analysis of activation curves. From the inactivation and activation curves, it was suggested that one of them with low threshold of activation may be partly involved in the repolarizing phase of pacemaker potentials. Bath application of TEA together with tetrodotoxin reversibly blocked the pacemaker potentials in current-clamp recordings. We conclude that the TEA-sensitive K+ current is the most likely candidate that contributes to the repolarizing phase of the pacemaker potentials of TN-GnRH cells.  (+info)

An intrinsic oscillation in interneurons of the rat lateral geniculate nucleus. (2/2760)

By using the whole cell patch recording technique in vitro, we examined the voltage-dependent firing patterns of 69 interneurons in the rat dorsal lateral geniculate nucleus (LGN). When held at a hyperpolarized membrane potential, all interneurons responded with a burst of action potentials. In 48 interneurons, larger current pulses produced a bursting oscillation. When relatively depolarized, some interneurons produced a tonic train of action potentials in response to a depolarizing current pulse. However, most interneurons produced only oscillations, regardless of polarization level. The oscillation was insensitive to the bath application of a combination of blockers to excitatory and inhibitory synaptic transmission, including 30 microM 6,7-dinitroquinoxaline-2,3-dione, 100 microM (+/-)-2-amino-5-phosphonopentanoic acid, 20 microM bicuculline, and 2 mM saclofen, suggesting an intrinsic event. The frequency of the oscillation in interneurons was dependent on the intensity of the injection current. Increasing current intensity increased the oscillation frequency. The maximal frequency of the oscillation was 5-15 Hz for most cells, with some ambiguity caused by the difficulty of precisely defining a transition from oscillatory to regular firing behavior. In contrast, the interneuron oscillation was little affected by preceding depolarizing and hyperpolarizing pulses. In addition to being elicited by depolarizing current injections, the oscillation could also be initiated by electrical stimulation of the optic tract when the interneurons were held at a depolarized membrane potential. This suggests that interneurons may be recruited into thalamic oscillations by synaptic inputs. These results indicate that interneurons may play a larger role in thalamic oscillations than was previously thought.  (+info)

Gating of afferent input by a central pattern generator. (3/2760)

Intracellular recordings from the sole proprioceptor (the oval organ) in the crab ventilatory system show that the nonspiking afferent fibers from this organ receive a cyclic hyperpolarizing inhibition in phase with the ventilatory motor pattern. Although depolarizing and hyperpolarizing current pulses injected into a single afferent will reset the ventilatory motor pattern, the inhibitory input is of sufficient magnitude to block afferent input to the ventilatory central pattern generator (CPG) for approximately 50% of the cycle period. It is proposed that this inhibitory input serves to gate sensory input to the ventilatory CPG to provide an unambiguous input to the ventilatory CPG.  (+info)

The biological clock of very premature primate infants is responsive to light. (4/2760)

Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light.  (+info)

Loss of the circadian clock-associated protein 1 in Arabidopsis results in altered clock-regulated gene expression. (5/2760)

Little is known about plant circadian oscillators, in spite of how important they are to sessile plants, which require accurate timekeepers that enable the plants to respond to their environment. Previously, we identified a circadian clock-associated (CCA1) gene that encodes an Myb-related protein that is associated with phytochrome control and circadian regulation in plants. To understand the role CCA1 plays in phytochrome and circadian regulation, we have isolated an Arabidopsis line with a T DNA insertion that results in the loss of CCA1 RNA, of CCA1 protein, and of an Lhcb-promoter binding activity. This mutation affects the circadian expression of all four clock-controlled genes that we examined. The results show that, despite their similarity, CCA1 and LHY are only partially redundant. The lack of CCA1 also affects the phytochrome regulation of gene expression, suggesting that CCA1 has an additional role in a signal transduction pathway from light, possibly acting at the point of integration between phytochrome and the clock. Our results indicate that CCA1 is an important clock-associated protein involved in circadian regulation of gene expression.  (+info)

How does beta-adrenergic stimulation increase the heart rate? The role of intracellular Ca2+ release in amphibian pacemaker cells. (6/2760)

1. The mechanism by which sympathetic transmitters increase the firing rate of pacemaker cells was explored in isolated cells from the sinus venosus of the cane toad Bufo marinus. Intracellular calcium concentration ([Ca2+]i) was measured with indo-1 and membrane potential and currents were recorded with the nystatin perforated-patch technique. 2. Adrenaline or isoprenaline (2 microM) increased the transient rise in [Ca2+]i and increased the firing rate; these effects were blocked by propranolol (2 microM). 3. To determine whether the changes in [Ca2+]i might influence the firing rate we studied agents which affect either the loading or the release of Ca2+ from the sarcoplasmic reticulum (SR). Rapid application of caffeine (10 mM) to spontaneously firing cells caused a large Ca2+ release from the SR and the cells were then quiescent for 24 s. In the presence of beta-adrenergic stimulation the caffeine-induced [Ca2+]i was 14 % larger but the period of quiescence after application was reduced to 12 s. 4. Ryanodine, at either low (1 microM) or high (> 10 microM) concentration, stopped firing. However, when the SR store content of Ca2+ was tested with caffeine, at low ryanodine concentration the SR Ca2+ store was empty whereas at the high concentration the SR store was still loaded with Ca2+. beta-Adrenergic stimulation was not able to restore firing at the low concentration of ryanodine but did restore firing at the high ryanodine concentration. 5. An SR Ca2+ pump blocker, 2, 5-di(tert-butyl)-1,4-hydroquinone (TBQ) which depletes the SR store of Ca2+, also rapidly and reversibly stopped spontaneous firing. 6. The relation between the amplitude of the [Ca2+]i transient and firing rate established in the presence of ryanodine was similar when firing was restored by beta-stimulation. 7. In both spontaneously firing and voltage-clamped cells, depleting the SR store with either ryanodine or TBQ suggested that about half of the Ca2+ which contributes to the calcium transient is released from the SR. 8. These results show that the amplitude of the [Ca2+]i transient is an important factor in the firing rate of toad pacemaker cells and consequently agents which modify SR Ca2+ release influence firing rate. The effects of beta-stimulation on firing rate seem to be largely mediated by changes in amplitude of the [Ca2+]i transient.  (+info)

Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle. (7/2760)

1. Development of the pacemaker system in the small intestine depends upon signalling via tyrosine kinase (Kit) receptors. The downstream pathways initiated by Kit in interstitial cells of Cajal (ICC) have not been investigated. Wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002), inhibitors of phosphatidylinositol 3'-kinase (PI3-kinase), were used to test the involvement of this pathway in the development and maintenance of ICC and electrical rhythmicity in the murine small intestine. 2. ICC and electrical slow waves were present in the murine jejunum at birth. ICC and electrical rhythmicity continued to develop in neonates such that adult activity was recorded after 1 week. Development of ICC and rhythmicity were maintained in organ culture. 3. Wortmannin or LY 294002 inhibited the development of slow waves and blocked rhythmicity within 2-4 days. Loss of slow waves was preceded by disappearance of Kit-positive cells from the myenteric (IC-MY) and deep muscular plexus (IC-DMP) regions. Wortmannin or LY 294002 had no acute effect on slow waves. 4. Muscles from older animals (day 10-day 30) developed resistance to wortmannin treatment, but when the exposure to wortmannin was increased to 35 days, damage to ICC networks and electrical dysrhythmias were observed. 5. PI3-kinase appears to be a critical downstream signalling element linking Kit receptors to ICC development and maintenance of phenotype. ICC are more sensitive to Kit or PI3-kinase blockade at birth, but the importance of the PI3-kinase signalling in the maintenance of ICC persists into adulthood. Interference with PI3-kinase signalling in immature or adult animals could result in disruption of ICC and gastrointestinal dysrhythmias.  (+info)

Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. (8/2760)

Circadian rhythms of mammals are entrained by light to follow the daily solar cycle (photoentrainment). To determine whether retinal rods and cones are required for this response, the effects of light on the regulation of circadian wheel-running behavior were examined in mice lacking these photoreceptors. Mice without cones (cl) or without both rods and cones (rdta/cl) showed unattenuated phase-shifting responses to light. Removal of the eyes abolishes this behavior. Thus, neither rods nor cones are required for photoentrainment, and the murine eye contains additional photoreceptors that regulate the circadian clock.  (+info)

The tick-tock of your biological clock may have just gotten a little louder.. Researchers at the University of Georgia report that the number of genes under control of in living things than suspected only a few years ago. The biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies that the clock may be much more important. This new finding may help to explain why the clock is so far-reaching in its effects on the organism, said Jonathan Arnold, a professor in the UGA department of genetics and director of the research project. We found that some 25 percent of the genes in our model organism appear to be under clock control. I wasnt suspecting anything remotely like that.. The new research, just published in the Public Library of Science One, also shows how Arnolds team used a new methodology called Computing Life to yield these new discoveries about biological clocks. And this tool of systems biology was the key to showing ...
December 31, 2008. Science Daily/Hebrew University of Jerusalem. Indulgence in a high-fat diet can not only lead to overweight because of excessive calorie intake, but also can affect the balance of circadian rhythms - everyones 24-hour biological clock, Hebrew University of Jerusalem researchers have shown.. The biological clock regulates the expression and/or activity of enzymes and hormones involved in metabolism, and disturbance of the clock can lead to such phenomena as hormone imbalance, obesity, psychological and sleep disorders and cancer.. While light is the strongest factor affecting the circadian clock, Dr. Oren Froy and his colleagues of the Institute of Biochemistry, Food Science and Nutrition at the Hebrew Universitys Robert H. Smith Faculty of Agriculture, Food and Environment in Rehovot, have demonstrated in their experiments with laboratory mice that there is a cause-and-effect relation between diet and biological clock imbalance.. To examine this thesis, Froy and his ...
Ivanhoe Newswire) -- If you regularly experience the pangs of jet lag or a crazy work schedule, then you may not be the biggest fan of your bodys biological clock. Fortunately, a new molecular compound dubbed longdaysin has recently shown the ability to trick it into slowing down or speeding up to potentially meet different needs.. Researchers at the University of California San Diego and three other research centers found longdaysin by conducting an automated screening of over 120,000 compounds using a robot designed to test the effects of the compounds on a series of human bone cancer cells. These cells were genetically altered with two genes: an attached clock gene, which stimulates the cells circadian rhythm, and a luciferase gene, which lights up when the biological clock was triggered (also seen in the glow of fireflies). The robot was programmed to isolate the molecules that showed the greatest effects on the cells biological clocks. After discovering longdaysin to be the most ...
NYU (US) - Biologists have uncovered one way that biological clocks control neuronal activity-a discovery that sheds new light on sleep-wake cycles. The findings answer a significant question-how biological clocks drive the activity of clock neurons, which, in turn, regulate behavioral rhythms, explains Justin Blau, an associate professor in New York Universitys department of biology and the studys senior author.. Their findings, which also offer potential new directions for research into ways to address sleep disorders and jetlag, appear in the Journal of Biological Rhythms.. [sources]. Scientists have known that our biological clocks control neuronal activity. But not previously understood is how this process occurs-that is, how does information from biological clocks drive rhythms in the electrical activity of pacemaker neurons that, in turn, drives daily rhythms?. To understand this mechanism, the researchers examined the biological, or circadian, clocks of Drosophila fruit flies, which ...
I am using vegetable juicing for many things. Not just weight loss but also to help me block the biological clock. That clock that ticks, ticks, ticks and lets me know I am getting older. Yes, the truth is there is more than one biological clock for a woman. Once the worry of children and…
2010. 26cm. Pp.280. Hardbound.Biological Clock in Fish reviews the state of knowledge in sufficient detail and presents the latest contributions to the field, showing fish provide a unique model of the circadian biological clock. 1578086752
Cellular and Molecular Bases of Biological Clocks: Models and Mechanisms for Circadian Timekeeping by Leland N. Jr. Edmunds and a great selection of similar Used, New and Collectible Books available now at AbeBooks.com.
Published in the journal BMC Biology, these results show for the first time that directly targeting the biological clock in a cancerous tumour has an impact on its development.. Most of the cells in the human body have an internal clock that sets a rhythm for the activities of our organs according to the time of the day. Cancer cells, however, often have a non-functioning or malfunctioning clock.. There were indications suggesting that the malfunctioning clock contributed to rapid tumour growth, but this had never been demonstrated. Thanks to the use of a chemical or a thermic treatment, we succeeded in repairing these cells clock and restoring it to its normal functioning. In these conditions, tumour growth drops nearly in half, explains Cermakian, who is also Director of the Laboratory of Molecular Chronobiology at the Douglas Mental Health University Institute, one of the research centres of the CIUSSS de lOuest-de-lÎle-de-Montréal.. Although this preclinical demonstration was done ...
Many observed rhythms in physiology and behavior often crucially depend on the presence of endogenous cycles and their production through biological clocks. Periodic rhythms, which are not simply responses to external periodic cues, have been documented for most living beings, including bacteria, fungi, plants, and animals. Biological clocks are self sustaining oscillators which will continue a period of free-running cycling even in the absence of external cues. However, clocks are usually linked to and can be reset by the environment via cues (i.e., Zeitgeber). Such entrainment keeps an organisms clock synched to its surrounding conditions. Circadian clocks must contain a minimum of three basic elements: (1) input pathway(s) relay environmental information to a circadian pacemaker; (2) the endogenous pacemaker (oscillator) generates temporal patterns; and (3) output pathway(s) for the pacemaker to regulate output rhythms. A search for biological clocks commonly attempts to isolate an organism ...
NADH oxidases at the external surface of plant and animal cells (ECTO-NOX proteins) exhibit stable and recurring patterns of oscillations with potentially clock-related, entrainable, and temperature-compensated period lengths of 24 min. To determine if ECTO-NOX proteins might represent the ultradian time keepers (pacemakers) of the biological clock, COS cells were transfected with cDNAs encoding tNOX proteins having a period length of 22 min or with C575A or C558A cysteine to alanine replacements having period lengths of 36 or 42 min. Here we demonstrate that such transfectants exhibited 22, 36, or 40 to 42 h circadian patterns in the activity of glyceraldehyde-3-phosphate dehydrogenase, a common clock-regulated protein, in addition to the endogenous 24 h circadian period length. The fact that the expression of a single oscillatory ECTO-NOX protein determines the period length of a circadian biochemical marker (60 X the ECTO-NOX period length) provides compelling evidence that ECTO-NOX proteins ...
A new study of molecular interactions central to the functioning of biological clocks explains how certain mutations can shorten clock timing, making some people extreme morning larks because their internal clocks operate on a 20-hour cycle instead of being synchronized with the 24-hour cycle of day and night.
The day and night cycle influences the body function in health and disease through the modulation of the biological clock in via the suprachiasmatic nucleus (SCN) which i..
The influence of noise is unavoidable in all living systems. Its impact on a model of a biological clock, normally running in regular oscillating modes, is examined. It is shown that in a specific system in which endogenous rhythmicity is produced by a beat oscillator acting on a feedback coupled metabolic pool system, noise can act coherently to produce unexpected dynamic behaviour, running from regular over pseudo-regular to irregular time-structures. If the biological system consists of a set of identical weakly coupled cells, stochasticity may lead to phase decoupling producing irregular spatio-temporal patterns. Synchronization via phase resetting can be achieved by external short-time temperature pulses. Explicit results are obtained for the well-studied circadian photosynthesis oscillations in plants performing crassulacean acid metabolism. Because of the generic structure of the underlying nonlinear dynamics they can, however, be regarded as a general property of the influence of noise ...
Alarm Clock Gene KDM5A Explains Wake-up Function of Biological Clock. Ever wondered why you wake up in the morning-even when the alarm clock isnt making jarring noises? Wonder no more.
Women in their 30s and early 40s who want to know whether their biological clocks are running out should skip fertility testing, a new study suggests.
Tricking algaes biological clock to remain in its daytime setting can dramatically boost the amount of valuable compounds these simple marine plants can produce when grown in constant light.
Washington, Aug 16 (ANI): Eyes use light to regulate the biological clock through a mechanism that is different from the ability to see, according to researchers at the University of Virginia. The finding
Researchers from the Vanderbilt University say that constant exposure to artificial light may interfere with the normal development of premature babies biological clocks.
Today I am grateful to science - it is som amazing, discovering and verifying the most amazing things! I was listening to the lecture of this Soviet scientist, Simon Shnoll, and he was telling about biological clocks that run in every living organism, and how they are aligned with the movements of earth, moon, and the…
Does the biological clock in cancer cells influence tumour growth? Yes, according to a study conducted by Nicolas Cermakian, a professor in McGill Universitys Department of Psychiatry.
Jennifer L. Fleissner; The Biological Clock: Edith Wharton, Naturalism, and the Temporality of Womanhood. American Literature 1 September 2006; 78 (3): 519-548. doi: https://doi.org/10.1215/00029831-2006-024. Download citation file:. ...
The homodimeric, growth-related and time-keeping constitutive hydroquinone oxidase ENOX1 of the eukaryotic cell surface capable of oxidizing extracellular NAD(P)H and intracellular hydroquinones...
In modern societies, the risk of developing metabolic disorders such as obesity or type-2 diabetes is associated with the prevalence of psychosocial stress. Therefore, an improved understanding of adaptive stress responses and their underlying molecular mechanisms is of high clinical interest. In response to an acute stressor, animals activate the sympathetic nervous system and the hypothalamus pituitary adrenal (HPA) axis releasing catecholamines and glucocorticoids (GCs) into the circulation. Recent data suggest that stress responses are also regulated by the endogenous circadian clock adapting physiology and behavior to the environmental changes brought about by the Earth s rotation around its axis. Thus, the timing of stress may critically affect adaptive responses to and the pathological effects of repetitive stressor exposure. We have studied the role of different tissue clocks on the regulation of HPA axis activity in mice. We further characterized the impact of predictable social defeat ...
Our bodies run on an in-built 24-hour clock embedded in a part of the brain called the suprachiasmatic nucleus (SCN). Its 20,000 nerve cells sit in the middle of the brain above the back of the eyes and on top of a structure called the hypothalamus. These are the bodys master timekeepers, setting the rhythm…
The general behavior of coupled neural oscillators is very difficult to analyze, however limiting cases can be treated ([22]). We will describe one method, the method of averaging, that has been used successfully to study the dynamics of two or more neural oscillators that are weakly coupled (e.g., Hansel [16] and Ermentrout and Kopell [9]). In this limit the coupling is sufficiently weak that each oscillators trajectory remains close to its intrinsic limit cycle. The primary effect of the coupling is to perturb the relative phase between the oscillators much as we described above. However, since the perturbation per cycle is small (with weak coupling) the net effect occurs only over many cycles and the per cycle effect is seen as averaged. For illustration, we summarize the use of averaging to describe the phase-locking properties of two identical Morris-Lecar oscillators when coupled with identical mutually excitatory synapses. Detailed derivations of the equations can be found in the above ...
γ oscillations are observed in the local field potential (LFP), which emerges as a result of spatially organized, summed current flow largely due to synaptic activity within a neural network (Mitzdorf, 1985; Barth et al., 1989; Einevoll et al., 2013). γ is the result of rhythmic synaptic output from cohorts of neurons with precise temporal relationships. However, there are varied mechanisms by which these temporal patterns occur within local neural circuits.. In the hippocampus, extensive exploration of computational and experimental models has identified multiple network mechanisms by which γ oscillations can be generated. Experimental work using pharmacological manipulations of the in vitro hippocampal slice preparation found that the 40 Hz-range field potential oscillations evoked under different circumstances exhibited different reliance on synaptic excitation and inhibition. γ oscillations induced by activating mGluR (Whittington et al., 1995) or kainate (Fisahn et al., 2004) receptors ...
BeWellBuzz) Circadian rhythm refers to any biological process which displays an endogenous oscillation of 24-hours. In simpler terms, it refers to your bodys internal biological clock. The term circadian comes from the Latin word circa meaning around and diem meaning day. Our biological clocks are governed by a group of interacting molecules throughout the body. A ... Continue Reading ...
Hendricks, J. C., Lu, S. M., Kume, K., Yin, J. C. P., Yang, Z. H., Sehgal, A. (2003) Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. Journal of Biological Rhythms, 18 (1). pp. 12-25. ISSN 0748-7304 Hengartner, M. O. (1997) Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans. Experimental Gerontology, 32 (4-5). pp. 363-74. ISSN 0531-5565 (Print) ...
body clock We live in a world that changes its levels of illumination and temperature every day and night of our lives. To make the best of opportunities and to avoid the risks posed by this variability, living things have evolved internal timing mechanisms, called biological clocks, which co-ordinate their metabolism and behaviour with the daily rhythm of the world. Source for information on body clock: The Oxford Companion to the Body dictionary.
Using the clock, researchers can gauge the age of diverse human organs and tissues. Unexpectedly, they found some parts of the anatomy, like womens breast ...
Numerous processes in our body fluctuate in a regular pattern during the day. These circadian (or daily) variations can be driven by local oscillators present within our cells or by systemic signals controlled by the master ...
division and reproduction of all cells from the single-celled amoeba to cells in the human body. The complexity and coordination of this cycle is staggering. The cell cycle is divided into four primary phases: G1, S, G2, and M.. G1, or the Gap 1 phase, is the time in which cells carry out all of the normal processes of the cell. Some cells remain in this phase for very long periods of time. But, when appropriate stimuli are encountered by a cell, a round of cell division is triggered. This point of no return is known as the restriction point. Once a cell passes this point, it must complete the entire cell cycle and return once more to G1. After a cell reproduces, it must prepare for the next phase of the cell cycle: S-phase or DNA synthesis phase. This preparation requires activating countless genes and making many new proteins that are used only during this one phase of the cell cycle. Once every component is ready, S-phase may begin.. During the DNA synthesis phase, the cell must make an exact ...
division and reproduction of all cells from the single-celled amoeba to cells in the human body. The complexity and coordination of this cycle is staggering. The cell cycle is divided into four primary phases: G1, S, G2, and M.. G1, or the Gap 1 phase, is the time in which cells carry out all of the normal processes of the cell. Some cells remain in this phase for very long periods of time. But, when appropriate stimuli are encountered by a cell, a round of cell division is triggered. This point of no return is known as the restriction point. Once a cell passes this point, it must complete the entire cell cycle and return once more to G1. After a cell reproduces, it must prepare for the next phase of the cell cycle: S-phase or DNA synthesis phase. This preparation requires activating countless genes and making many new proteins that are used only during this one phase of the cell cycle. Once every component is ready, S-phase may begin.. During the DNA synthesis phase, the cell must make an exact ...
Prior to dying the cell creates an offspring which carries on the same cellular characteristics as the mother cell. Because of the cellular damage done by cancer cells, the biological clock is altered and cancer cells do not die but proliferate. So not only does the mother cancer cell not die, but the offspring inherit the same characteristics as the mother which includes a broken biological clock.. As a result of this cancer cell population explosion, tumors are formed.. Haelan repairs the cellular damage and as a by product of this repair restores the normal programmed cell death (apoptosis) and cells resume their normal biologically determined cell death cycle. Since all cells resume their death cycle, cancer cells cease to grow and consequently die off.. 4. Increases the cyto-toxic effect of the NK Killer cells - Natural Killer cells (or NK cells) constitute a major component of the innate immune system. They play a major role in the rejection of tumors and cells infected by viruses. The ...
During the years 1976 through 1980, 15% of U.S. adults were obese. Today, about 40% of adults are obese. Another 33% are overweight.
The acceleration in genome sequencing capacity is just incredible. In May 2010, I posted on the sequencing of the complete genomes of two parents and two of their kids. Now in August of 2012 we have the results on the complete genomes of 78 parent children trios, along with 1,859 complete sequences from the same…
They dont really supply proper data for survivorship at 1 year, while at 2 years, a close analysis shows 13% and 9% increases in mean and max LS (vs. GFP), but ALL of these animals are well within the historical norm for C57Bl/6 LS. Again - husbandry is a huge, huge issue in these types of studies - if I can get to the same or greater max or mean LS through proper husbandry, then your entire study is invalidated, because whatever treatment you are giving might merely be alleviating bad husbandry, and not a true life extension (example, if the diet you give the animals, lacks in f.ex. a vital vitamin, and you supply that vitamin and now extend the life span of the supplemented animals vs the improperly fed ones, what kind of life extension is this - it certainly is not compared to animals properly fed... i.e. your vitamin supplement would fail to extend the lifespan of properly fed animals). This is why it is critical to show max or mean LS extension against lifespan records of a given line ...
A new method for egg freezing called vitrification-a technology that its architects say will revolutionize the world of assisted reproduction -- is making the process of in vitro fertilization (IVF) less costly and more efficient than ever before.
Japanese researchers have developed a compound that can speed up the flowering of plants, a finding that could be used to allow agriculture even in colder
For this study, AMH levels were measured in 144 healthy, fertile women and the data were used to determine an estimate of mean AMH as a function of age. This information was then used to estimate the distribution of the age of menopause in a sample of 3,384 women between the ages of 50 and 70. Researchers were then able to develop a model based on AMH level and age that could predict age at menopause for individual women ...
Films Media Group, an Infobase Learning Company, is the premier source of high-quality academic streaming video and DVDs for schools, colleges, and libraries.
MangaHelpers is a place where you can find translations and scanlations for Shonen Manga, Shoujo Manga, Jyousei Manga as well as downloads for all your favorite manga series. MangaHelpers also is a community resource that helps translators and scanlators get their work known to a wider audience and thus increasing the popularity of lesser known Manga.
Modern reproductive technologies can give older women the same chances of having a baby as younger women, researchers reported Wednesday. The new study
From a young age Ive preferred babies to animals. Babies laugh at things adults find unamusing. They coo freely as if cantillating inner satisfaction. They are squishy and snuggly and impressed by my singing voice.
Journalists may submit queries online for fastest response. Journalists can also mail [email protected] or call 212-305-3900 to reach a member of the CUMC news office team.. Patients, please visit ColumbiaDoctors. ...
When Sarah Gardner was 34, she started getting really worried about whether she'd ever have kids. "I bought this kit online that said that they
Sustained molecular oscillations are ubiquitous in biology. The obtained oscillatory patterns provide vital functions as timekeepers, pacemakers and spacemarkers. Control-theory type models have been introduced to explain how specific oscillatory behaviors stem from protein interaction feedbacks, whereas the energy dissipation through the oscillating processes and its role in the regulatory function remain elusive. Here we developed a general framework to assess oscillators regulation performance at different dissipation levels. Using Escherichia coli MinCDE oscillator as model system, we showed that, unlike stationary regulators monotonic performance-to-cost relation, excess dissipation at certain steps in the oscillating process damages the oscillators regulatory performance. We further discovered that ATP hydrolysis energy has to be strategically assigned to the MinE-aided MinD release and the MinD immobilization steps for optimal performance, and higher energy budget improves the ...
Everyone is equipped with a biological clock, a region in the brain of the size of a corn kernel, which dictates our sleep-wake cycles. A research conducted by Kent State professor David Glass has shown that this clock can be re-set, reported science portal EurekAlert ...
Single and alternating hand tapping were compared to test the hypothesis that coordination during rhythmic movements is mediated by the control of specific time intervals. In Experiment 1, an auditory metronome was used to indicate a set of timing patterns in which a 1-s interval was divided into 2 …
How does the body know how old it is? Our metabolisms change as we get older, even though our DNA doesnt change. Different genes are activated at different times of life, and the timing of gene expression is what controls growth, development, sexual maturity, and perhaps aging as well. The body keeps accurate track of how old it is, though there has been no scientific agreement about where the clocks are, or how they work. Recently, some biologists have suggested that one such biological clock might reside in the epigenetic state of the DNA. If this is true, epigenetics will become an attractive, though challenging, target for anti-aging research. If we knew where the body kept its clock, then perhaps we could target the clock itself with biochemical interventions. We would not just be able to slow the progress of aging, but reset the clock to an earlier age.. DNA is decorated with methyl groups, small molecular add-ons that act like Do Not Disturb signs for the underlying gene. A gene that ...
The human "biological clock". Sleep timing depends greatly on hormonal signals from the circadian clock, or Process C, a ... The circadian clock has its own set of genes.[39] Genes which may influence sleep include ABCC9,[40] DEC2,[41][42] and variants ... "Sleep and Biological Rhythms. 14: 89-99. doi:10.1007/s41105-015-0018-6. PMC 4732678. PMID 26855610.. ... The internal circadian clock is profoundly influenced by changes in light, since these are its main clues about what time it is ...
Lewis, Alan (1999). Melatonin and the Biological Clock. McGraw-Hill. p. 23. ISBN 978-0-87983-734-1.. ... Perreau-Lenz S, Pévet P, Buijs RM, Kalsbeek A (January 2004). "The biological clock: the bodyguard of temporal homeostasis". ... Guardiola-Lemaître B (December 1997). "Toxicology of melatonin". Journal of Biological Rhythms. 12 (6): 697-706. doi:10.1177/ ... Many animals use the variation in duration of melatonin production each day as a seasonal clock.[87] In animals including ...
Ishida N, Kaneko M, Allada R (August 1999). "Biological clocks". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8819-20. Bibcode: ... A homolog of CLOCK plays the same role in the human clock, and CYC is replaced by BMAL1. CRY has two human homologs, CRY1 and ... per has also been implicated in the regulation of several output processes of the biological clock, including mating activity ... Spanagel R, Rosenwasser AM, Schumann G, Sarkar DK (August 2005). "Alcohol consumption and the body's biological clock". Alcohol ...
Ishida, N; Kaneko, M; Allada, R (1999). "Biological clocks". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8819-20. Bibcode:1999PNAS ... Clock - The clock gene in Drosophila encodes for the CLOCK protein and forms a heterodimer with the protein CYCLE in order to ... In the mammalian circadian clock, for example, transcription factors CLOCK and BMAL1 are the positive regulators. CLOCK and ... Clock - Clock, also known as Circadian Locomotor Output Cycles Kaput, is a transcription factor in the circadian pacemaker of ...
Ishida N, Kaneko M, Allada R (August 1999). "Biological clocks". Proceedings of the National Academy of Sciences of the United ... Vrille mRNA and protein product (VRI) oscillate predictably on a 24-hour timescale and interact with other circadian clock ... Ohno T, Onishi Y, Ishida N (March 2007). "The negative transcription factor E4BP4 is associated with circadian clock protein ... Blau J, Young MW (December 1999). "Cycling vrille expression is required for a functional Drosophila clock". Cell. 99 (6): 661- ...
Ishida N, Kaneko M, Allada R (August 1999). "Biological clocks". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8819-20. Bibcode: ... Konopka and Orr found that light pulses reset the mutant clock to a greater extent than the wild type clock (about 10 hours for ... In contrast to Clock, Andante lengthens the period of eclosion, and locomotor activity by 1.5-2 hours, and was also shown to ... In 1990, Konopka collaborated with Mitchell S. Dushay and Jeffery C. Hall to further investigate the effects of the clock gene ...
ISBN 0-691-02402-2. Arthur T. Winfree (1987). Timing of Biological Clocks. Scientific American Library, No 19. ISBN 0-7167-5018 ... University of Chicago 1972-1979 Associate professor of biological sciences, Purdue University 1979-1986 Professor of biological ... Winfree was noted for his work on the mathematical modeling of biological phenomena (see Complexity and Singularity (system ... CS1 maint: discouraged parameter (link) Cohen, Joel E. (1982). "Review: The geometry of biological time, by Arthur T. Winfree ...
"Men Have Biological Clocks, Too". Retrieved September 15, 2015. "A Social History of Sperm". Barlow, Jim. "UO sociologist wins ...
Galileo project entry SEDS Biography At the dawn of chronobiology Biological Clocks - Garden Variety Experiments Clock Classics ... "Biological Clocks - Garden Variety Experiments". HHMI. Archived from the original on 10 June 2013. Retrieved 5 April 2011. de ... Despite Marchant's publication of de Mairan's work, which might have suggested the existence of endogenous biological clocks, ... However, de Mairan did not infer that heliotropes have internal clocks driving leaf rhythms, but rather that they were able "to ...
CS1 maint: discouraged parameter (link) Urist, Jacoba (October 21, 2013). "Men Have Biological Clocks, Too". The Atlantic. ...
Millar AJ (4 January 2002). "Biological clocks in Arabidopsis thaliana". New Phytologist. 141 (2): 175-197. doi:10.1046/j.1469- ... the two sides of the Drosophila circadian clock". Journal of Biological Rhythms. 27 (6): 433-42. doi:10.1177/0748730412463181. ... "Clk Clock [Drosophila melanogaster (fruit fly)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-04-11. "FlyBase Allele ... Mapping and cloning of the gene indicates that it is the Drosophila homolog of the mouse gene CLOCK (mClock). The Jrk mutation ...
The Physiological Clock, 1958) Biological clocks; Chairman's Address; Cold Spring Harbor Symposium (1960) Interference of ... "XXV: Biological Clocks 1960". CSHL Digital Photo Archives. Retrieved 7 April 2015. CS1 maint: discouraged parameter (link) ... From his results, Bünning proposed that biological clocks have sensors for both light and dark, and their relationship aids ... In 1960, he chaired in the 25th Cold Spring Harbor Symposium, "Biological Clocks". The next year, Bünning was elected ...
"Biological clocks 'beat quicker' in cities". BBC. 5 June 2013. Retrieved 5 June 2013. Wilford, John Noble (5 June 2013). "Palm- ... The clock's measurements could form a new basis for global time standards, replacing the present generation of atomic clocks.[ ... 10 July French scientists construct an ultra-precise optical lattice clock that misses only one second in 300 million years. ... Following a large-scale genome study, researchers identify some of the biological roots of migraine, a chronic neurological ...
The Biological Clock. Two Views. Academic Press. 1970. Frank A. Brown Jr. The "Clocks" Timing Biological Rhythms: Recent ... Brown envisioned the biological clock as being a duality in which an internal responder to subtle information from the ... Cole, Lamont C. Biological Clock in the Unicorn. Science, Volume 125, Issue 3253, pp. 874-876. 1957 Heusner, A. 1965. "Sources ... The Biological Clock Phenomenon: Exogenous Timing Hypothesis. J. interdiscipl. Cycle Res., Vol. 14, number 2, pp. 137·162. Webb ...
In addition, the biological clock (which is regulated by the hypothalamus) stimulates hunger. Processes from other cerebral ...
Fisch H, Braun S (2005). The male biological clock: the startling news about aging, sexuality, and fertility in men. New York: ... "Male biological clock: a critical analysis of advanced paternal age". Fertil. Steril. 103: 1402-6. doi:10.1016/j.fertnstert. ... The paternal age effect is the statistical relationship between paternal age at conception and biological effects on the child. ... "Contrasting Effects of Maternal and Paternal Age on Offspring Intelligence: The clock ticks for men too". PLoS Med. 6 (3): e42 ...
Evolving Biological Clocks using Genetic Regulatory Networks - Information page with model source code and Java applet. ... At one level, biological cells can be thought of as "partially mixed bags" of biological chemicals - in the discussion of gene ... Knabe JF, Nehaniv CL, Schilstra MJ, Quick T (2006). "Evolving Biological Clocks using Genetic Regulatory Networks". Proceedings ... Trajectories correspond to the unfolding of biological pathways and transients of the equations to short-term biological events ...
Pittendrigh is regarded as the "father of the biological clock," and founded the modern field of chronobiology alongside Jürgen ... Here, he continued his studies of biological clocks, working with the faculty and lecturing at Montana State University - ... "Perspectives in the study of biological clocks." Perspectives in Marine Biology, AA Buzati-Traverso, ed, 239-268, University of ... in establishing many of the key criteria that a biological system must have in order to be considered a biological clock. His ...
Biological clocks and circadian timing in cells". EMBO Reports. 6 Spec No (Suppl 1): S9-13. doi:10.1038/sj.embor.7400424. PMC ... In 2005, Tei, G. Lundkvist, Y. Kwak, E. Davis, and G. Block proposed that the molecular clock was linked to neurons' membrane ... In 2000, using their rodent model, they discovered the existence of circadian clocks in peripheral organs of mammals. This ... In 2016, a research team that included Tei discovered that clock genes, most specifically Bmal1 and Per1, are rhythmically ...
This suggests that animals have a biological clock that can serve as a CS. This method has also been used to study timing ... An example of conditioned hunger is the "appetizer effect." Any signal that consistently precedes a meal, such as a clock ... As an adaptive mechanism, emotional conditioning helps shield an individual from harm or prepare it for important biological ...
Yuferov V, Butelman ER, Kreek MJ (October 2005). "Biological clock: biological clocks may modulate drug addiction". European ... which is essential for resetting the biological clock.[citation needed] Recent research suggests that, outside the SCN, clock ... "Human Biological Clock Set Back an Hour". Harvard Gazette. 1999-07-15. Retrieved 2019-01-28. Azzi, A; Evans, JA; Leise, T; ... In mammals, circadian clock genes behave in a manner similar to that of flies. CLOCK (circadian locomotor output cycles kaput) ...
Lewis A (1999). Melatonin and the Biological Clock. McGraw-Hill. p. 23. ISBN 978-0-87983-734-1. Valdés-Tovar M, Estrada-Reyes R ... Perreau-Lenz S, Pévet P, Buijs RM, Kalsbeek A (January 2004). "The biological clock: the bodyguard of temporal homeostasis". ... Nearly 70% of biological damage caused by ionizing radiation is estimated to be attributable to the creation of free radicals, ... Lincoln GA, Andersson H, Loudon A (October 2003). "Clock genes in calendar cells as the basis of annual timekeeping in mammals- ...
clock". J. Exp. Biol. 97: 121-136. PMID 7201003. Dunlap, J.; Hastings, J.W. (1981). "The biological clock in Gonyaulax. ... For over 50 years he also had an affiliation with the Marine Biological Laboratory in Woods Hole, Massachusetts. He was the ... In 1953 he joined the faculty in the Department of Biological Sciences at Northwestern University. In 1954 he began a long ... Wilson, T. and Hastings, J.W. (1970) Chemical and biological aspects of singlet excited molecular oxygen. Photophysiology (A.C ...
The Biological Clocks that Control the Daily Lives of Every Living Thing[14][15] and Seasons of Life: The Biological Rhythms ... Leon Kreitzman; Russell G. Foster (2004). Rhythms of life: the biological clocks that control the daily lives of every living ... Leon Kreitzman; Russell G. Foster (2009). Seasons of Life: The Biological Rhythms That Enable Living Things to Thrive and ... From 1988 to 1995 Foster was a member of the National Science Foundation Center for Biological Rhythms at the University of ...
In most cases, it is not known what causes the abnormality in the biological clocks of DSPD patients. DSPD tends to run in ... DSPD is a disorder of the body's timing system-the biological clock. Individuals with DSPD might have an unusually long ... biological clock), compared to those of the general population and societal norms. The disorder affects the timing of sleep, ... hour and have extreme difficulty waking because their biological clocks are not in phase with that schedule. Non-DSPD people ...
"Transhumanist science will free women from their biological clocks". Quartz. "The Language of Aliens Will Always Be ...
They are genetic experiments with their biological clocks stopped. They encounter Toothpick, a companion cyber from the days ...
This regular oscillation is attributed to the maintenance of biological clock NADH activity of ENOX2 has been shown to be ... 2002). "Biochemical basis for the biological clock". Biochemistry. 41 (40): 11941-5. doi:10.1021/bi020392h. PMID 12356293. ... "Biochemical basis for the biological clock". Biochemistry. 41 (40): 11941-11945. doi:10.1021/bi020392h. ISSN 0006-2960. PMID ...
CS1 maint: discouraged parameter (link) Ingle, Roisin (September 15, 2007). "Tick-tock goes the biological clock". Irish Times ...
... basing it on their biological clocks rather than on the brightness or darkness of their environments. The researchers believe ... Biological Sciences. 286 (1910). doi:10.1098/rspb.2019.1161. PMC 6742986. PMID 31506058.. ... "Biological Journal of the Linnean Society. 109 (2): 257-270. doi:10.1111/bij.12039.. ... Biological Sciences, vol. 286, no. 1910, 2019, p. 20191161., doi:10.1098/rspb.2019.1161. ...
Biological process. • anterior/posterior pattern specification. • multicellular organism development. • anterior/posterior axis ...
Measurements bound to a range and repeating (like degrees in a circle, clock time, etc.), graded membership categories, and ... Examples of these classifications include gender, nationality, ethnicity, language, genre, style, biological species, and form. ...
... windmills and clocks. The Renaissance brought forth many of these innovations, including the printing press (which facilitated ... including the possibility of the permanent alteration of our biological nature. These concerns are shared by other philosophers ...
Sharov, Alexei A (2006). "Genome increase as a clock for the origin and evolution of life". Biology Direct. 1 (1): 17. doi: ... The evolution of biological complexity is one important outcome of the process of evolution.[1] Evolution has produced some ... From a biological perspective, there is no such thing as devolution. All changes in the gene frequencies of populations--and ... Later scientists regarded biological devolution as nonsense; rather, lineages become simpler or more complicated according to ...
Rubidium and caesium are often used in atomic clocks.[205] Caesium atomic clocks are extraordinarily accurate; if a clock had ... Lithium naturally only occurs in traces in biological systems and has no known biological role, but does have effects on the ... Biological role and precautionsEdit. MetalsEdit. Pure alkali metals are dangerously reactive with air and water and must be ... Rubidium has no known biological role, but may help stimulate metabolism,[234][235][236] and, similarly to caesium,[234][237] ...
Khalid al-Kaysarani contructed the first striking clock in 1154 as part of a clock tower, similar to the Big Ben, near the ... mirip dengan pakaian dipakai oleh askar-askar moden untuk perlindungan terhadap senjata biological, kimia dan nukelar. Oleh ... Ia adalah clock in which an automaton reacted pertama selepas sesetengah interval waktu, yang mana dalam kes ini adalah sebuah ... Striking clock: According to a 1202 manuscript written by Ridhwan al-Sa'ati, Abu 'Abdullah Muhammad b. Naser b. Saghir b. ...
Research has identified health-behavioral and biological factors that are related to increased risk for CVD. These risk factors ...
Biological Reviews. 78 (2): 251-345. doi:10.1017/S1464793102006103. PMID 12803423.. *^ a b Sahney, S., Benton, M.J. & Falcon- ... Lee, Michael SY; Cau, Andrea; Darren, Naish; Gareth J., Dyke (2013). "Morphological Clocks in Paleontology, and a Mid- ... "Proceedings of the Royal Society B: Biological Sciences. 274 (1610): 635-640. doi:10.1098/rspb.2006.3763. PMC 2197205. PMID ... Biological and Biomedical Sciences. 39 (3): 298-313. doi:10.1016/j.shpsc.2008.06.004. PMID 18761282.. ...
To determine when subjects felt the intention to move, he asked them to watch the second hand of a clock. After making a ... Other forms of determinism are more relevant to compatibilism, such as biological determinism, the idea that all behaviors, ... and biological, cultural and psychological determinism feed the development of compatibilist models. Separate classes of ... in which case it represents a form of biological determinism.[94] ... movement, the volunteer reported the time on the clock when ...
Biological classification * sw:Uainishaji wa kisayansi. Biological materials * sw:Biological materials. Biology * sw:Biology. ... Clock * sw:Clock. Clothing * sw:Clothing. Cloud * sw:Cloud. Coffee * sw:Coffee. Cold War * sw:Cold War. Colonialism * sw: ...
Doomsday Clock. *End time. *List of dates predicted for apocalyptic events. *Nibiru cataclysm ... Biological data visualization. *Ecocline. *Ecological economics. *Ecological footprint. *Ecological forecasting. *Ecological ...
"Official population clock". BBS.gov.bd. Archived from the original on September 4, 2011. Retrieved October 4, 2014.. ... "Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines". PNAS ... "World Population Clock: 7.7 Billion People (2019) - Worldometers". www.worldometers.info. Retrieved April 27, 2019.. .mw-parser ... "Chinese Official Population Clock (updated daily, in Chinese)". National Bureau of Statistics of China. Retrieved August 23, ...
Michael's parents gifted him one of Darwin's books on evolution and biological mysteries. The book described biological clocks ... The location and composition of these clocks were unknown, and this sparked Michael Young's interest at an early age.[6] ... This discovery solidified doubletime as a necessary part of the circadian clock.[18] ... 2006: Pittendrigh/Aschoff Award from the Society for Research on Biological Rhythms[2] ...
Water accelerates corrosion of metal parts and is a favorable medium for biological growth. Dissolved minerals in natural water ... but it started to become noticeably more prevalent after the introduction of the first Gigahertz-clocked processors in the ...
Proceedings of the Royal Society B: Biological Sciences. 276 (1676): 4087-4094. doi:10.1098/rspb.2009.1339. PMC 2821352. PMID ... Both molecular clock data and new fossil finds suggest that the lemuriform divergence from the other primates and the ... A sample of strepsirrhine diversity; eight biological genera are depicted (from top, left to right): Lemur, Propithecus, ... Molecular clock estimates indicate that lemurs and the lorisoids diverged in Africa during the Paleocene, approximately 62 mya ...
Gregory Scott Charak (2007). Between Soul and Precision: Ernst Mach's Biological Empiricism and the Social Democratic ... "molecular clock", which enabled the neutral theory of molecular evolution.[365] ... He was the first person to use the term genetics to describe the study of heredity and biological inheritance, and the chief ... He is best known for arguing that the complexity of biological systems and organisms might result as much from self- ...
"Argument from biological development": At the end of this section there is, quite rightly, a "citation needed" tag. ... However, neuroscientists don't traffic in mind-body dualism (not while they're on the clock anyway). Any suggestion to contrary ...
"The Journal of Biological Chemistry. 223 (2): 897-905. PMID 13385237.. *^ Burns JJ, Moltz A, Peyser P (December 1956). "Missing ... According to molecular clock dating, these two suborder primate branches parted ways about 63 to 60 million years ago.[143] ... "The Journal of Biological Chemistry. 289 (5): 2515-2525. doi:10.1074/jbc.M113.514828. PMC 3908387. PMID 24347170.. ... In biological systems, ascorbic acid can be found only at low pH, but in solutions above pH 5 is predominantly found in the ...
Ereshefsky, M. (2001). The Poverty of the Linnaean Hierarchy: A Philosophical Study of Biological Taxonomy. Cambridge ... These "molecular clocks", however, are fallible, and provide only a very approximate timing: for example, they are not ... "Neoproterozoic - Cambrian Biological Revolutions" (PDF). Paleontological Society Papers. 10: 67-78. Archived from the original ... Main articles: Biological classification, Cladistics, Phylogenetic nomenclature, and Evolutionary taxonomy. .mw-parser-output ...
Two-Potato Clock - Science Kit and Boreal Laboratories[permanent dead link]. Accessed 10 April 2007. ... Sony has developed a biological battery that generates electricity from sugar in a way that is similar to the processes ... "Two-potato clocks" are also widely available in hobby and toy stores; they consist of a pair of cells, each consisting of a ... wired in series to form a battery with enough voltage to power a digital clock.[74] Homemade cells of this kind are of no ...
"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 64A (4): 481-486. doi:10.1093/gerona/gln045. ... A third option is assisted living where 24-hour round-the-clock supervision is given with aid in eating, bathing, dressing, etc ... Key Concepts in Social Gerontology lists four dimensions: chronological, biological, psychological, and social.[24]:12-3 Wattis ... Old age is not a definite biological stage, as the chronological age denoted as "old age" varies culturally and historically.[6 ...
The American Institute of Biological Sciences published a similar paper in support of this concept in 2009.[10] In addition, ... Doomsday Clock. *Gray goo. *Kinetic bombardment *Relativistic kinetic kill vehicle. *Mutual assured destruction *Dead Hand ...
"Philosophical Transactions: Biological Sciences. 353 (1372): 1081-91. doi:10.1098/rstb.1998.0267. PMC 1692311. PMID 9720106.. ... Molecular clock and fossil dating suggest platypuses split from echidnas around 19-48 million years ago.[71] ... "Philosophical Transactions: Biological Sciences. 353 (1372): 1115-25. doi:10.1098/rstb.1998.0270. PMC 1692310. PMID 9720109.. ... "Philosophical Transactions: Biological Sciences. 353 (1372): 1221-37. doi:10.1098/rstb.1998.0278. PMC 1692306. PMID 9720117.. ...
... the Clock Mosque in Peqin and the two domed mosques in Elbasan dating from the 17th century.[70] Of the roughly 1,127 Islamic ... racist and biological terminology has been used by some Albanian intellectuals when discussing Islam and Albanians.[158][159] ...
خلقیات study of natural or biological character. *اقدار study of economic and ethical principles of a society ... Horography art of constructing sundials or clocks. *ساعتیات science of time measurement ...
"Chronobiology International: The Journal of Biological and Medical Rhythm Research. 25 (1): 65-81. doi:10.1080/ ... entering the eye that affects the human body's clock. ...
Cryptochromes absorb blue light and UV-A. Cryptochromes entrain the circadian clock to light.[6] It has been found that both ... A number of biological and behavioural changes are dependent on this knowledge. Together with temperature changes, photoperiod ... Fankhauser, Christian (2001). "The Phytochromes, a Family of Red/Far-red Absorbing Photoreceptors". Journal of Biological ... with the rhythms of the circadian clock that allows plants to measure the length of the night. Other than flowering, ...
The Journal of Biological Chemistry. 265 (33): 20602-8. PMID 2173715.. *^ a b Raikhinstein M, Hanukoglu I (November 1993). " ... organization and coordination of central and peripheral clocks". Annual Review of Physiology. 72: 517-49. doi:10.1146/annurev- ... ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological ...
Doomsday Clock. *End time. *List of dates predicted for apocalyptic events. *Nibiru cataclysm ...
"Proceedings of the Royal Society B: Biological Sciences. 278 (1716): 2333-2337. PMC 3119002 . PMID 21208965. doi:10.1098/rspb. ... Birds that use the sun compensate for the changing position of the sun during the day by the use of an internal clock.[62] ... Biological exuberance: Animal homosexuality and natural diversity. New York: St. Martin's, 1999. pp. 479-655. One hundred ... Based on fossil and biological evidence, most scientists accept that birds are a specialised subgroup of theropod dinosaurs,[19 ...
Media in category "Biological clocks". The following 77 files are in this category, out of 77 total. ... A-Proposed-Mechanism-for-the-Interaction-of-the-Segmentation-Clock-and-the-Determination-Front-in-pone.0001561.s001.ogv 20 s, ... A-Proposed-Mechanism-for-the-Interaction-of-the-Segmentation-Clock-and-the-Determination-Front-in-pone.0001561.s002.ogv 20 s, ... A-Spatio-Temporal-Model-of-Notch-Signalling-in-the-Zebrafish-Segmentation-Clock-Conditions-for-pone.0016980.s002.ogv 1 min 0 s ...
Scientists are still debating how and why the circadian clocks that govern biological timekeeping evolved. ... "Theres a clock in the liver. Theres a clock in the adipose [fat] tissue. Theres a clock in the spleen," says Barbara Helm, a ... The origin of biological clocks. The evolutionary story of circadian rhythms is under scrutiny. ... The original biological timepiece may not have resembled the precision body clocks that scientists study today. The ancestral ...
... A new treatment for infertility eventually could improve womens prospects for having babies later ... Should these treatments change the way we think about the biological clock? ...
Biological clocks underlie many of the biorhythms [1] seen in organisms (e.g. hibernation in animals). ... biological clock* The mechanism, presumed to exist within many animals and plants, that produces regular periodic changes in ... Biological clocks underlie many of the biorhythms seen in organisms (e.g. hibernation in animals). They continue to run even ... biological clock The mechanism, presumed to exist within many animals and plants, that produces regular periodic changes in ...
... your biological clock may not be running as far ahead as you think. ... your biological clock may not be running as far ahead as you think. ... you know that having a biological family one day is really, really important to you and you dont have any imminent plans to ... you know that having a biological family one day is really, really important to you and you dont have any imminent plans to ...
... so knowledge that the process is under clock control adds a dramatic new dimension to the clocks inherent biological value as ... Biological clocks hold the key to much of life and disease processes. In February 2007, Arnolds team reported in the ... The biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies ... "It appears the clock influences a number of biological processes, including cell cycling, protein metabolism and varied ...
... A mans age when he has children is turning out to be an important factor in that childs ... Kelsey Hubbard talks to the author about the role a mans biological clock plays in a childs risk for diseases and disorders ... I ... its the thought that unlike when in mens biological clocks had no alarm ... it certainly is alarming that new findings ...
Is your biological clock ticking? Find out how long you really have. ... Biological Clock at Conception : Women are having children later and later these days. ... Is your biological clock ticking? [offsite link]. Keeping Positive Waiting for something robs you of time you have today....how ... Is your biological clock ticking? Find out how long you really have. At Home Pregnancy Tests [offsite link]. Very sensitive, ...
The biggest tick of my biological clock, the pivotal event in my relationship with my parents, came from someone elses. I had ... Yes, I feel like I am racing against a clock, but its a bit more complicated than that. ... with MTV blaring in a language you barely understand while you watch the clock slowly tick off the minutes until the misery of ...
Hunky bachelor Matthew McConaughey showed his paternal side by going gaga over a baby Down Under.The ever-shirtless bongo player, hanging at an Australian…
Resetting the biological clock. May 15, 2012 2:46 PM Subscribe. First Gene Therapy Successful Against Aging-Associated Decline ... slows down the biological clock -- was successful. The research provides a proof-of-principle that this feasible and safe ... Cancer comes from the accumulation of mutations in key biological pathways over time. Exist for more time and youre likely to ...
... believe they have discovered a new mechanism by which the brain sends signals to the rest of the body to control biological ... New Insights on Biological Clock. By Rick Nauert PhD Associate News Editor ... Experts believe learning how the human biological clock works is an essential step toward correcting sleep problems like ... But Forgers British colleagues were able to separate clock cells from non-clock cells by zeroing in on the ones that expressed ...
Fighting the male biological clock by banking sperm By Elizabeth Cohen, Senior Medical Correspondent ... Fisch, author of the book "The Male Biological Clock: The Startling News About Aging, Sexuality, and Fertility in Men," said he ...
Purchase Circadian Rhythms and Biological Clocks Part B, Volume 552 - 1st Edition. Print Book & E-Book. ISBN 9780128033807, ... Circadian Rhythms and Biological Clocks Part B, Volume 552 1st Edition. 0 star rating Write a review ... Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area ... Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms ...
The researchers next tested longdaysin on zebrafish larvae and found that it augmented their biological clocks by more than 10 ... The robot was programmed to isolate the molecules that showed the greatest effects on the cells biological clocks. After ... "A compound that makes the clock slow down or speed up can also be used to phase-shift the clock - in other words, to bump or ... biological clocks. They found that the molecules three different protein kinesis were responsible for the effect and that one ...
A newly designed epigenetic clock gives new clues and accurately predicts lifespan. ... Could our body clock help to prevent cancer?. Researchers reveal how a newly discovered role for our biological clock, or ... Epigenetic clock can calculate biological age, predict lifespan Written by Tim Newman on September 30, 2016 ... Our current focus is on understanding what biological mechanisms control the 'ticking' of the epigenetic clock and ...
They helped uncover the mechanisms behind the biological clock present in the cells of all living things, called the circadian ... The work of the biological clock is obvious after cross-country or intercontinental flights, when jet lag leaves you tired and ... Three Americans won the Nobel Prize for biological clocks find. They study the rhythm of our cells. ... Everybody has a cellular "clock."ikukevk via Unsplash. U.S. scientists Jeffrey C. Hall, Michael Rosbash and Michael W. Young ...
The body clock controls circadian rhythms, the 24-hour cycle that governs biological processes in humans, animals, plants, and ... Biological clocks control much of human biology, including aging, hormones, sleep, fertility, and seasonal cycles. ... The Body Clock. Every tissue and organ in your body operates according to biological rhythms. The so-called body clock keeps ... Body Clock Over Time. The body clock undergoes many changes as a person ages. The clocks of newborn babies induce them to sleep ...
... plants have a biological clock. Scientists suggest that following plant biological clocks when making decisions on herbicide ... New research suggests that timing herbicide application to the biological clocks of plants may improve both its efficacy and ... 19 (UPI) -- Like humans, plants have a circadian rhythm, or biological clock. Scientists suggest that following plant circadian ... we might be able to refine the use of some chemicals that are used in agriculture by taking advantage of the biological clock ...
Guys may have a biological clock, too. By Josh Rosenblatt Published July 03, 2017 Newser ... This article originally appeared on Newser: Bad News, Guys: Your Biological Clock Is Ticking, Too ...
A new study has provided direct evidence that biological clocks can influence the activity of a large number of different genes ... Daylight Saving Time Interferes With Human Biological Clock. When people in some parts of the world advance their clocks by one ... "This is one of the first pieces of evidence that the biological clock exerts its effect on DNA structure through the coiling of ... A new study has provided direct evidence that biological clocks can influence the activity of a large number of different genes ...
How they work to keep the biological clock ticking is amazing!. Cyclin-dependent kinases function as enzymes, with the ability ... In a physical clock or watch, a system of gears and shafts are designed to keep the clock moving, keeping precise, accurate ... the cell division cycle-our own biological clock. [NOTE: The following discussion of cell division is based on Alberts, et al ... Just as clocks are constructed by an intelligent designer, the cell cycle is clear evidence for intelligent design in the ...
Carskadon points out that teenagers "biological clocks" are telling them that they should be home in bed at 7:30 a.m. and not ... Heed teenagers biological clocks. Posted Thursday, April 4, 2013 1:00 pm ...
Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration. Tetsuhiro S. ... Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration ... Circadian clocks-ubiquitous in life forms ranging from bacteria to multicellular organisms-often exhibit intrinsic temperature ... Circadian clocks-ubiquitous in life forms ranging from bacteria to multicellular organisms-often exhibit intrinsic temperature ...
Biological clocks regulate everything from behavior to metabolism and play a crucial role in our health. ... Three scientists have won the Nobel prize in Medicine for research into our internal clocks. ... Three scientists have won the Nobel prize in Medicine for research into our internal clocks. Biological clocks regulate ... Three scientists have won the Nobel prize in Medicine for research into our internal clocks. Biological clocks regulate ...
As a result, physicians remain divided on just how much weight to give the notion of a male biological clock. ... The conventional wisdom is clearly inaccurate: Men have as important a biological clock as women for having healthy babies, ...
... explores how anaesthesia affects the bodys biological clock and whether light therapy could help reduce sleep disruption post ... "All organisms that you choose to look at have got innate, endogenous biological clocks and those clocks are adjusted on a daily ... Shining a light on our biological clock. From Our Changing World, 9:20 pm on 17 September 2015 ... It drives our daily rhythms and sleep cycles, but this biological clock can get out of sync during general anaesthesia. The ...
"Our research suggests that men, too, have a biological time clock-only it is different," she added. "Men seem to have a gradual ... "We know that women have a biological time clock, with an increase in risk of miscarriage and producing children with trisomy-an ...
Tick-tock biological clock. By Razib Khan , June 27, 2010 12:46 am ... Tweets that mention Tick-tock biological clock , Gene Expression , Discover Magazine -- Topsy.com , June 27, 2010 ...
Tag Archives: topic:biological clocks. Amherst College, School, Smith College, Uncategorized Oscillations in biological clock ... category:projectsfaculty:Mary Harringtonfaculty:Tanya Leiseschool:Amherst Collegeschool:Smith Collegetopic:biological clocks ... "clock genes" generated through negative feedback loops in the expression of these genes. Recently, oscillations in clock gene ... In mice, the source of the internal clock that maintains internal physiological rhythms in the absence of external cues, is a ...
  • Researchers believe they have discovered a new mechanism by which the brain sends signals to the rest of the body to control biological rhythms. (psychcentral.com)
  • Every tissue and organ in your body operates according to biological rhythms. (medicinenet.com)
  • It drives our daily rhythms and sleep cycles, but this biological clock can get out of sync during general anaesthesia. (radionz.co.nz)
  • In mice, the source of the internal clock that maintains internal physiological rhythms in the absence of external cues, is a region of the hypothalamus called the suprachiasmatic nucleus (SCN). (smith.edu)
  • In the context of the current topic of biological time then Foster and Kreitzman's highly accessible book "Rhythms of Life" (2004) deals with this in detail as well as providing a more in depth review of the whole field than can be achieved in a short essay. (gresham.ac.uk)
  • PER proteins are part of a complex feedback loop in which changes in their abundance set the timing of circadian rhythms, so mutations that increase the rate of PER degradation throw off the clock. (news-medical.net)
  • Partch noted that it is important to understand how these clock proteins regulate our circadian rhythms, because those rhythms affect not only the sleep cycle but almost every aspect of our physiology. (news-medical.net)
  • Drosophila fruit flies are commonly used for research on biological, or circadian, clocks because of the relative ease of finding mutants with non-24-hour rhythms and then identifying the genes underlying the altered behavior. (innovations-report.com)
  • Since circadian rhythms are important for almost every aspect of our physiology, when the biological clock is not properly aligned with Earth's 24-hour day, it can cause a variety of problems ranging from social jet lag to metabolic and degenerative diseases," explained UC San Diego's Clarisse Ricci, a McCammon Group researcher who co-authored the research paper recently published in eLife . (ucsd.edu)
  • Many people with sleep phase disorders have changes in their clock proteins," said Carrie Partch, associate professor of chemistry and biochemistry at UC Santa Cruz and a lead author of the paper, explaining that PER proteins are part of a complex feedback loop in which changes in their abundance set the timing of circadian rhythms, while mutations that increase the rate of PER degradation throw off the clock. (ucsd.edu)
  • A new study led by UC Santa Cruz researchers has found that a protein associated with cancer cells is a powerful suppressor of the biological clock that drives the daily ('circadian') rhythms of cells throughout the body. (fiercebiotech.com)
  • The discovery, published in the June 4 issue of Molecular Cell (and online now), adds to a growing body of evidence suggesting a link between cancer and disruption of circadian rhythms, while offering new insights into the molecular mechanisms of the biological clock. (fiercebiotech.com)
  • The clock is not always disrupted in cancer cells, but studies have shown that disrupting circadian rhythms in mice causes tumors to grow faster, and one of the things the clock does is set restrictions on when cells can divide,' she said. (fiercebiotech.com)
  • While biological clocks are vital to maintaining healthy patterns of sleep, metabolism, physiology and behavior, under certain environmental conditions strict adherence to these rhythms can be disadvantageous," said Michael Sesma of the National Institute of General Medical Sciences, which partially funded the work. (bio-medicine.org)
  • The potential importance of changes in synonymous codon usage in adapting to environmental factors is magnified by the fact that they can influence the operation of biological clocks, which function as a key adaptation to daily environmental rhythms. (bio-medicine.org)
  • This study therefore suggests that biological rhythms may play a role in controlling immune function in night-shift workers," added Dr. Marc Cuesta, a postdoctoral fellow who works in the laboratories of Dr. Boivin and Dr. Cermakian. (science20.com)
  • Daily rhythms of sleep and metabolism are driven by a biological clock in the suprachiasmatic nucleus (SCN), a structure in the brain made up of 20,000 neurons, all of which can keep daily (circadian) time individually. (kurzweilai.net)
  • Biological Clocks, Rhythms, and Oscillations Edition by Daniel B. Forger and Publisher The MIT Press. (vitalsource.com)
  • We found that in both LD and DD, the overall rhythm of the clock nucleus is composed of individual cellular rhythms that peak in distinct phase groups at 3-4 hr intervals. (jneurosci.org)
  • It is clear that these "clock genes" produce ∼24 hr rhythms in individual cells through interlocked transcription-translation feedback loops ( Albrecht, 2002 ). (jneurosci.org)
  • Bancroft discusses how dawn and dusk, alarm clocks, and daily routines indicate circadian rhythms. (films.com)
  • The Clock, Per, and Tim genes regulate circadian rhythms. (films.com)
  • A biological clock pertains to any of the various mechanisms that regulate biological rhythms such as sleep and wakefulness cycle, body temperature, patterns of hormone secretion, blood pressure, digestive secretions, alertness levels, reaction times, etc. 1 Biological rhythms is the synchronized cyclic pattern demonstrated by an organism as its response to a particular stimulus. (biology-online.org)
  • Biological Rhythms. (biology-online.org)
  • Ueli Schibler, profes- sor at the University of Geneva (UNIGE), Switzerland, unveils a mo- lecular mechanism by which body temperature rhythms influence the expression of 'clock genes' and synchronize local oscillators. (phys.org)
  • This developmental process, called eclosion, served as a powerful tool to study the complicated biological process of circadian rhythms. (theconversation.com)
  • It's the same type of biological balancing act that keeps everything from your blood sugar levels to your circadian rhythms in line throughout your body. (theconversation.com)
  • Circadian Rhythms and Biological Clocks Part A Edition by Sehgal, Amita and Publisher Academic Press. (vitalsource.com)
  • Daily rhythms of physiology and behaviour are governed by an endogenous timekeeping mechanism (a circadian 'clock'), with the alternation of environmental light and darkness synchronizing (entraining) these rhythms to the natural day-night cycle. (royalsocietypublishing.org)
  • Central to this adaptation is the evolution of an endogenous, self-sustained, 24 h (circadian) timekeeping mechanism ('clock') that orchestrates body rhythms for concerted action and synchronizes (entrains) them to the local time of day [ 1 ]. (royalsocietypublishing.org)
  • By recording the daily rhythms of hormones and body temperatures in 24 healthy young and old men and women over a one-month period, the researchers conclude that our internal clocks run on a daily cycle of 24 hours, 11 minutes. (harvard.edu)
  • Our biological clock drives circadian rhythms - physical, mental, and behavioral changes that follow a roughly 24-hour cycle. (cancertutor.com)
  • The study of circadian rhythms is called chronobiology - and now there is science behind the theory that targeting the biological clock could slow the progression of cancer. (cancertutor.com)
  • Circadian biology assumes that biological rhythms maximize fitness by enabling organisms to coordinate with their environment. (royalsocietypublishing.org)
  • Circadian clocks underlie biological rhythms with a periodicity of approximately 24 h across a range of taxa, spanning from bacteria to plants, insects and vertebrates. (royalsocietypublishing.org)
  • Both the evolutionary and mechanistic explanations of this periodicity are poorly understood, but that it is always a multiple of 24 h suggests that circadian clocks regulate parasite rhythms. (royalsocietypublishing.org)
  • Reflects the recent advances in the study of biological rhythms in different areas such as molecular genetics, cell functions, neurobiology, biochemistry, physiology and pharmacology. (nhbs.com)
  • Molecular, Cellular and Genetic Aspects of Biological Rhythms. (nhbs.com)
  • Models of temperature compensation in biological rhythms (P. Ruoff). (nhbs.com)
  • The study of endogenous rhythms in human beings owes a great deal to the fruit fly, Drosophila , because it was in this insect that genes homologous to those involved in the human biological clock were first identified. (mcgill.ca)
  • CLOCK (Circadian Locomotor Output Cycles Kaput) or Clock is a gene encoding a basic helix-loop-helix-PAS transcription factor that is believed to affect both the persistence and period of circadian rhythms. (wikipedia.org)
  • Research shows that the CLOCK gene plays a major role as an activator of downstream elements in the pathway critical to the generation of circadian rhythms. (wikipedia.org)
  • Dr. Paolo Sassone-Corsi and colleagues demonstrated in vitro that CLOCK mediated HAT activity is necessary to rescue circadian rhythms in Clock mutants. (wikipedia.org)
  • These cells were genetically altered with two genes: an attached clock gene, which stimulates the cell's circadian rhythm, and a luciferase gene, which lights up when the biological clock was triggered (also seen in the glow of fireflies). (redorbit.com)
  • U.S. scientists Jeffrey C. Hall, Michael Rosbash and Michael W. Young received the 2017 Nobel Prize in Physiology or Medicine today for their work uncovering the mechanisms behind the biological clock-present in the cells of all living things-called the circadian rhythm. (popsci.com)
  • Aug. 19 (UPI) -- Like humans, plants have a circadian rhythm, or biological clock. (upi.com)
  • Scientists have long known that animals and plants are governed by a circadian rhythm-a roughly 24-hour cycle guiding biological processes that is linked to alternating periods of light and dark. (medgadget.com)
  • There are a lot of articles on how some light can affect your circadian rhythm aka your internal body clock. (simplyled.co.uk)
  • Circadian clock refers to the various mechanisms that result in a circadian rhythm . (biology-online.org)
  • In many ways, the various circadian rhythm disorders may occur due to biologic clocks that have lost their synchrony to the natural environment. (verywellhealth.com)
  • Researcher examining a white laboratory rat during research into its biological clock or circadian rhythm. (sciencephoto.com)
  • Matching the host circadian rhythm appears to be achieved using output from host clocks as a time cue for scheduling progression throughout the cell (replication) cycle. (royalsocietypublishing.org)
  • Our biological clock-or circadian rhythm-adapts our body's cells and organs to changing requirements at different times of day. (medicalxpress.com)
  • TUESDAY, Oct. 10, 2017 (HealthDay News) -- Women in their 30s and early 40s who want to know whether their biological clocks are running out should skip fertility testing, a new study suggests. (medicinenet.com)
  • TUESDAY, Oct. 10, 2017 -- Women in their 30s and early 40s who want to know whether their biological clocks are running out should skip fertility testing, a new study suggests. (upi.com)
  • The ancestral clock may have started out as simple as a sundial, researchers say, but it provided a foundation for building the more elaborate mechanisms that now control everything from blood pressure to bedtime. (sciencenews.org)
  • Studies in the fruit fly Drosophila have revealed the molecular basis of the biological clock, and similar mechanisms are thought to occur in other animals, including mammals. (encyclopedia.com)
  • To simulate day and night cycles, the researchers modified the bacteria to glow and blink whenever arabinose-a chemical that triggered the oscillatory clock mechanisms of the bacteria-was flushed through the microfluidic chip. (medgadget.com)
  • Understanding these molecular mechanisms may enable scientists to develop therapies for intervening in the clock to alleviate disruptions, whether they are caused by inherited conditions or by shift work or jet lag. (news-medical.net)
  • Once Kay's group had isolated longdaysin, it turned to biological chemists in Peter Schultz's laboratory at The Scripps Research Institute to characterize the molecule and figure out the mechanisms of how it lengthened the biological clock. (scienceblog.com)
  • Partch's lab is continuing to investigate the biochemical mechanisms involved in the protein's interactions with the molecular clock. (fiercebiotech.com)
  • Science does not fully understand the mechanisms through which peripheral biological clocks adapt to night-shift work in humans, but it is thought that these clocks essentially depend on the central clock. (science20.com)
  • With that gene in their sights, the labs of Hall, Rosbash and Young ushered in the molecular era of circadian biology as they untangled the molecular mechanisms of biological timekeeping. (theconversation.com)
  • First, the majority of recent research in the field of chronobiology has focused on asking questions about clock mechanisms [ 7 - 11 ]. (royalsocietypublishing.org)
  • We hypothesize that a perturbed interaction between neutrophil elastase and serpins or other substrates may regulate mechanisms governing the clock-like timing of haematopoiesis. (nih.gov)
  • The resulting molecular mechanism or genetic network for the clock identified by this mode-guided discovery process will have a broad appeal to geneticists, physiologists and those with an interest in signaling pathways," said Arnold. (redorbit.com)
  • The UGA scientists discovered how three genes in Neurospora make such a clock tick at the molecular level. (redorbit.com)
  • Andrade RP, Palmeirim I, Bajanca F (2007) Molecular clocks underlying vertebrate embryo segmentation: a 10-year-old hairy-go-round. (springer.com)
  • A new study of molecular interactions central to the functioning of biological clocks explains how certain mutations can shorten clock timing, making some people extreme 'morning larks' because their internal clocks operate on a 20-hour cycle instead of being synchronized with the 24-hour cycle of day and night. (news-medical.net)
  • Digging deeper into the molecular workings of the clock, Panda and his colleagues found that each morning, JARID1a reactivates CLOCK and BMAL1 by countering the action of a brake protein HDAC1. (scienceblog.com)
  • Understanding circadian proteins at the molecular level can enable scientists to develop innovative therapies for fixing clock dysfunctions caused by inherited conditions, modern habits, shift working or aging," said Ricci. (ucsd.edu)
  • The conformational switch mechanism and the molecular details revealed by our work could help in the development of drugs targeting the kinase component of the clock. (ucsd.edu)
  • A master clock in the brain, tuned to the daily cycle of light and dark, sends out signals that synchronize the molecular clocks ticking away in almost every cell and tissue of the body. (fiercebiotech.com)
  • A series of experiments in Partch's lab revealed how the protein interacts with the molecular machinery of the biological clock. (fiercebiotech.com)
  • There are four main clock genes, and the interactions of these genes and the proteins they encode create a feedback loop that drives molecular oscillations on a 24-hour cycle. (fiercebiotech.com)
  • In another recent paper from Partch's lab, published May 11 in Nature Structural & Molecular Biology, researchers at UC Santa Cruz and the University of Memphis worked out important details of the interactions between two of the main clock proteins. (fiercebiotech.com)
  • The dates of the divergences of these new species can now be timed with molecular clocks based on the evolution of DNA. (theconversation.com)
  • However, molecular clocks do not tick uniformly. (theconversation.com)
  • Scientists in Scotland are already researching how biological clocks are involved in malaria, and a team of medical researchers last month won the Nobel Prize for research on the molecular structure of the biological clock of fruit flies. (eurekalert.org)
  • However, the organization of these individual molecular oscillators into a "biological clock" controlling behavior and physiology remains to be fully elucidated. (jneurosci.org)
  • Other concepts related to biological clock are senescence , circadian clock, epigenetic clock, and molecular clock. (biology-online.org)
  • In 2004, Johnson was a member of the team that determined the molecular structure of a circadian clock protein for the first time. (nanowerk.com)
  • Arnold's team uncovered a remarkable 295 genes that are influenced by the biological clock""and that number could be dramatically higher, given the conservative controls the researchers put on their work. (redorbit.com)
  • After discovering longdaysin to be the most powerful, the researchers analyzed the molecule to determine its characteristics and find out how it managed to lengthen the cells' biological clocks. (redorbit.com)
  • The researchers next tested longdaysin on zebrafish larvae and found that it augmented their biological clocks by more than 10 hours. (redorbit.com)
  • The conventional wisdom is clearly inaccurate: Men have as important a biological clock as women for having healthy babies,' says Dr. Dolores Malaspina of Columbia University , one of several researchers of this 'paternal age' effect. (baltimoresun.com)
  • To remedy the problem, UC San Diego biology professor Jeff Hasty led a team of researchers to develop a model biological system that is simpler than that of an organism. (medgadget.com)
  • While scientists have known for several years that our body's internal clock helps regulate many biological processes, researchers have found that the reverse is also true: Many common biological processes - including insulin metabolism - regulate the clock, according to a new study by investigators at the University of Pennsylvania School of Medicine, the Genomics Institute of the Novartis Research Foundation, and the University of California at San Diego. (emaxhealth.com)
  • The clock-influencing genes are involved in a large number of biological processes, but the researchers found that components of insulin metabolism, folate metabolism, and the cell cycle were overrepresented in the gene screen, suggesting that these pathways are closely linked to the clock. (emaxhealth.com)
  • The biological clock - timekeeper for virtually every activity within living things, from sleep patterns to respiration - is a single protein, Purdue University researchers report. (innovations-report.com)
  • Although researchers suspect the slowing down of an aging person's biological clock has many causes, there might be a simple solution: dietary supplements. (acs.org)
  • If the work extends to humans-and the researchers caution that this has not yet been established-supplementing with polyamines could help keep biological clocks running on time. (acs.org)
  • In the new study, researchers focused on mutations in an enzyme called casein kinase 1 (CK1), which regulates a core clock protein called PERIOD (or PER). (news-medical.net)
  • Using an automated screening technique developed by pharmaceutical companies to find new drugs, a team of researchers from UC San Diego and three other research institutions has discovered a molecule with the most potent effects ever seen on the biological clock. (scienceblog.com)
  • The researchers demonstrated the dramatic effects of longdaysin by lengthening the biological clocks of larval zebra fish by more than 10 hours. (scienceblog.com)
  • The researchers then showed that longdaysin had the same effect of lengthening the biological clock in mouse tissue samples and zebra fish larvae that carried luciferase genes attached to their clock genes. (scienceblog.com)
  • In the new study, the researchers identified the DNA uptake machinery in the cyanobacterium Synechococcus elongatus and discovered that the internal circadian clocks within their cells prevent DNA uptake early in the day and enhance the process early at night. (newswise.com)
  • Researchers from the Vanderbilt University say that constant exposure to artificial light may interfere with the normal development of premature babies' biological clocks. (medindia.net)
  • The researchers found that the lighting in the hospital interferes with the master biological clock in the babies. (medindia.net)
  • At the University of Georgia researchers are discovering that the biological clock of organisms is tied to a much larger set of genes than was previously thought. (medgadget.com)
  • Researchers at the Salk Institute for Biological Studies have identified a new component of the biological clock, a gene responsible for starting the clock from its restful state every morning. (scienceblog.com)
  • aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Biological Clocks and Evolution. (waset.org)
  • A study by researchers at New York University and the University of London offers additional evidence that mammals and fruit flies share a common genetic makeup that determines the function of their internal biological clocks. (innovations-report.com)
  • The researchers sought to determine additional roles for Cry in fruit flies by testing the rhythmic expression of clock genes in flies with either a mutant version of Cry, or with Cry produced at artificially high levels. (innovations-report.com)
  • According to Ricci, researchers have been showing that a healthy and robust clock can delay the onset of degenerative diseases and revert metabolic conditions such as diabetes and obesity. (ucsd.edu)
  • When the researchers looked at the 88 "clock sites" from the mouse rDNA in white blood cells from healthy adult humans and human embryonic stem cells, the latter were found to be much younger. (plos.org)
  • The researchers also studied cancer cell lines that express PASD1 and showed that blocking the protein (using RNA interference techniques) turned the clock cycle back on in those cells. (fiercebiotech.com)
  • An interdisciplinary team of researchers at Vanderbilt University has analyzed the simplest known biological clock and figured out what makes it tick. (science20.com)
  • In 2005, a group of Japanese researchers surprised the scientific community by showing that the three proteins which make up the biological clock in blue green algae will establish a 24-hour cycle on their own when placed in a test tube with adenosine triphosphate (ATP), the chemical that powers biological reactions. (science20.com)
  • aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Biological Clocks and Immune System. (waset.org)
  • A study by Vanderbilt University researchers published online Feb. 17 by the journal Nature provides compelling new evidence that at least some species can alter the way that their biological clocks function by using different "synonyms" that exist in the genetic code. (bio-medicine.org)
  • Researchers have long surmised diabetes and obesity could be the result of problems with our internal clock, leading biologists at University of California, San Diego to explore whether there is indeed a link. (emaxhealth.com)
  • Researchers have reported the discovery of a crucial part of the biological clock in the brain: wiring that sets its accuracy to within a few minutes out of the 1440 minutes per day. (kurzweilai.net)
  • The researchers discovered that the clock consisted of three proteins: KaiA, KaiB and KaiC. (nanowerk.com)
  • In the current study, the researchers discovered that two components of the clock, KaiA and KaiC, act as switches that turn the cell s daytime and nighttime genes on and off. (nanowerk.com)
  • 24] A novel technique developed by researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) will help shine new light on biological questions by improving the quality and quantity of information that can be extracted in fluorescence microscopy. (vixra.org)
  • Many scientists favor the view that multiple organisms independently evolved their own circadian clocks, each reinventing its own wheel. (sciencenews.org)
  • The original biological timepiece may not have resembled the precision body clocks that scientists study today. (sciencenews.org)
  • Three scientists have won the Nobel prize in Medicine for research into our internal clocks. (npr.org)
  • This is a story we first told you back in 2015, which we revived today because three scientists have won the Nobel Prize in physiology or medicine for their research into how these clocks work. (npr.org)
  • We've known for a long time about the master clock in our brains that synchronizes our body to the 24-hour, light-dark cycle, but in recent years, scientists have made a pretty cool discovery. (npr.org)
  • In this way, the scientists were able to simulate periodic day-night cycles over a period of only minutes instead of days to better understand how a population of cells synchronizes its biological clocks. (medgadget.com)
  • Even in the early 1960s, scientists knew that cancer patients and the elderly often experienced disorders thought to be related to the biological clock. (innovations-report.com)
  • IVF success rates halve by the time a man turns 50 irrespective of their female partner's age, according to a group of Melbourne scientists who are pushing for greater awareness of the male biological clock. (brisbanetimes.com.au)
  • Dubbed by the scientists "longdaysin," for its ability to dramatically slow down the biological clock, the new compound and the application of their screening method to the discovery of other clock-shifting chemicals could pave the way for a host of new drugs to treat severe sleep disorders or quickly reset the biological clocks of jet-lagged travelers who regularly travel across multiple time zones. (scienceblog.com)
  • Now scientists at the University of California San Diego studying photosynthetic bacteria called cyanobacteria, or "blue-green algae," have identified the roots of a behavior that is regulated by the circadian clock. (newswise.com)
  • Before the team's latest research, scientists had found only 16 clock-controlled genes in Neurospora, in more than 40 years of research. (medgadget.com)
  • Nobody else has used such a model to dig for genes under the control of a biological clock, so the possibility of what comes next makes both scientists-normally serious and fairly quiet-sit up with obvious delight. (medgadget.com)
  • Scientists knew that two genes, CLOCK and BMAL1, served as the key drivers for raising PER protein levels. (scienceblog.com)
  • Scientists from UC San Diego, UC Santa Cruz and Duke University synchronized their research watches to study what makes our biological clocks tick. (ucsd.edu)
  • Scientists have uncovered a molecule that affects our biological clock that they say can easily be developed into a drugs to treat metabolic disorders like diabetes and obesity. (emaxhealth.com)
  • Now knowing that the parasite has its own biological clock, scientists such as de Bekker can hone in on answering how and why this phenomenon occurs. (eurekalert.org)
  • De Bekker sees the role of biological clocks in infectious diseases as the next big thing for scientists to study. (eurekalert.org)
  • Scientists can better understand how diseases internally impact humans by knowing more about parasites and their impact on the biological clock. (eurekalert.org)
  • This year's Nobel Prize in Physiology or Medicine was awarded to three American scientists , Jeffrey Hall and Michael Rosbash of Brandeis University and Michael Young of Rockefeller University, for shedding light on how time is measured each day in biological systems, including our own bodies. (theconversation.com)
  • When the scientists examined the master biological clocks in the mouse brains, using a gene that makes the clock cells glow green when active, they found a similar pattern: slowing of the gene clocks in winter-born mice compared to those born on a summer light cycle. (vanderbilt.edu)
  • You know, the biological clock is every woman's demon, really. (npr.org)
  • But the truth of the matter is the biological clock governs every phase of a woman's reproductive system. (indigo.ca)
  • As an example, if a woman's biological clock is ticking, it means that she is becoming older and her ability to conceive and carry a healthy child to term may be in decline. (verywellhealth.com)
  • While slowing down a woman's biological clock remains as futile as turning back time, reproductive medicine is finding a way to peer inside the clock to gauge just how fast it is ticking. (aruplab.com)
  • At particular times of day, certain clock proteins switch on production of messenger RNA, used by the cell to bake fresh batches of other clock proteins. (sciencenews.org)
  • Taking the example of circadian clocks with cyanobacterial proteins KaiABC, consisting of several phosphorylation sites, we show that this temperature compensation mechanism is indeed valid. (pnas.org)
  • Neurons in the SCN exhibit oscillations in mRNA and proteins levels of "clock genes" generated through negative feedback loops in the expression of these genes. (smith.edu)
  • Many people with sleep phase disorders have changes in their clock proteins. (news-medical.net)
  • The whole feedback loop involving CK1, PERIOD, and other core clock proteins is found in all animals from insects to humans. (news-medical.net)
  • But, until now, the precise nature of the nighttime brake and what let CLOCK and BMAL proteins overcome this brake to raise PER protein levels again each morning was a mystery. (scienceblog.com)
  • The rDNA of the new clock encodes those ribosomal proteins. (plos.org)
  • Two proteins, CLOCK and BMAL1, form a complex that turns on the Period and Cryptochrome genes. (fiercebiotech.com)
  • The Period and Cryptochrome proteins then combine to turn off the genes for CLOCK and BMAL1. (fiercebiotech.com)
  • Although the biological clock consists of only three basic parts - proteins that have been labeled KaiA, KaiB and KaiC - when they began analyzing what was taking place in the test tube they discovered a lot more was going on than they had imagined. (science20.com)
  • PER and CRY proteins form a heterodimer which acts on the CLOCK-BMAL heterodimer to repress the transcription of per and cry. (wikipedia.org)
  • PER and CRY proteins accumulate and dimerize during subjective night, and translocate into the nucleus to interact with the CLOCK:BMAL1 complex, directly inhibiting their own expression. (wikipedia.org)
  • In February 2007, Arnold's team reported in the Proceedings of the National Academy of Sciences the first working model that explains how biological clocks operate. (redorbit.com)
  • This would help your body catch up when it is jet lagged or reset it to a normal day-night cycle when it has been thrown out of phase by shift work," Steve Kay, UCSD Division of Biological Sciences dean, and head researcher was quoted as saying. (redorbit.com)
  • The fact that oscillations can act as a regulatory mechanism is telling us something important about how DNA works: It is something DNA jockeys really need to think about," said Vanderbilt University Professor of Biological Sciences Carl Johnson, who headed the research. (medindia.net)
  • Hogenesch is a co-senior author on the paper with Steve Kay, Dean of the Division of Biological Sciences at UCSD. (emaxhealth.com)
  • In a study published this week in the Proceedings of the National Academy of Sciences , they report how a critical white blood cell called the macrophage, when exposed to bacteria, makes the biological clock inside the macrophage stop, allowing it to become inflamed. (medicalnewstoday.com)
  • Theoretically, longdaysin or a compound like it could be used to correct sleep disorders such as the genetic disorder familial advanced sleep syndrome, which is characterized by a clock that's running too fast," said Steve Kay, dean of UCSD's Division of Biological Sciences, who headed the research team, which published its findings in the December 14 issue of the journal PLoS Biology . (scienceblog.com)
  • That was a big surprise," says Carl Johnson, the professor of biological sciences who headed the new study. (science20.com)
  • This provides organisms with a novel and previously unappreciated mechanism for responding to changes in their environment," said Professor of Biological Sciences Carl Johnson. (bio-medicine.org)
  • He and Associate Professor of Biological Sciences Antonis Rokas collaborated on the study. (bio-medicine.org)
  • The cryptochrome discovery was made by Steve Kay, dean of the Division of Biological Sciences at UC San Diego. (emaxhealth.com)
  • We have shown that manipulating cyanobacteria s clock genes can increase its production of commercially valuable biomolecules, said Carl Johnson , Stevenson Professor of Biological Sciences at Vanderbilt University, who performed the study with collaborators at the J. Craig Venter Institute in Rockville, MD and Waseda University in Tokyo. (nanowerk.com)
  • The experiment provides the first evidence for seasonal imprinting of biological clocks in mammals and was conducted by Professor of Biological Sciences Douglas McMahon, graduate student Chris Ciarleglio, post-doctoral fellow Karen Gamble and two undergraduate students at Vanderbilt University. (vanderbilt.edu)
  • Graduate student Chris Ciarleglio (left) and Douglas McMahon, professor of biological sciences. (vanderbilt.edu)
  • We demonstrate for the first time that smoking status can be predicted using blood biochemistry and cell count results and the recent advances in AI and machine learning," says Dr. Olga Kovalchuk, a professor in the Department of Biological Sciences, Board of Governors Chair in Epigenetics of Health and Disease, and Canadian Institute of Health Research Chair in Gender and Health. (uleth.ca)
  • They govern the flow of hormones and regulate the body's response to sugar and many other important biological processes ( SN: 4/10/10, p. 22 ). (sciencenews.org)
  • This is one of the first pieces of evidence that the biological clock exerts its effect on DNA structure through the coiling of the chromosome and that this, in turn, allows it to regulate all the genes in the organism," said co-author Mark A Woelfle. (medindia.net)
  • Biological clocks regulate everything from behavior to metabolism and play a crucial role in our health. (npr.org)
  • Though it is well established that light is the primary factor regulating our body's biological clock, it was unknown if or how physiological factors could regulate the SCN. (medicalxpress.com)
  • Our study is the first to show that the SCN is listening to physiological signals and that such signals can in fact regulate clock time," says Bourque. (medicalxpress.com)
  • biological clock The mechanism, presumed to exist within many animals and plants, that produces regular periodic changes in behaviour or physiology. (encyclopedia.com)
  • The work done in his laboratory focuses on maximizing our understanding of "the gears in the biological clock" and their impacts on physiology. (eurekalert.org)
  • The ticking of the biological clock drives fluctuations in gene activity and protein levels that give rise to daily cycles in virtually every aspect of physiology in humans and other animals. (fiercebiotech.com)
  • A critical question is how these individual oscillators are organized into an internal clock that times behavior and physiology. (jneurosci.org)
  • A cornerstone of chronobiology is the idea that organisms have evolved circadian clocks to allow coordination of physiology and behaviour with the Earth's daily rotation [ 2 ]. (royalsocietypublishing.org)
  • It appears the clock influences a number of biological processes, including cell cycling, protein metabolism and varied signaling processes," said Arnold. (redorbit.com)
  • Biological clocks hold the key to much of life and disease processes. (redorbit.com)
  • The so-called body clock keeps body processes running according to a schedule. (medicinenet.com)
  • This ensures that there is a periodicity with necessary biological processes. (medicinenet.com)
  • Future research, they say, should be focused on identifying the specific biological processes to determine how to better optimize the use of glyphosate and other herbicides. (upi.com)
  • Previous studies have discovered that biological clocks help organize a dizzying range of biochemical processes in the body. (medindia.net)
  • The new data, published online in Cell this week, suggest that someday physicians may be able to use small molecules that inhibit or stimulate these biological processes in order to influence a person's clock when it gets out of sync due to jetlag or shift work. (emaxhealth.com)
  • Clock biologists all appreciated that the communication went one direction - from the clock to biological processes - but I don't think anyone anticipated that there would be this level of integration with cell metabolism and the cell cycle, or all these other pathways impinging on clock function," says John Hogenesch, PhD, Associate Professor of Pharmacology in the Institute for Translational Medicine and Therapeutics at Penn. (emaxhealth.com)
  • The idea that biological processes might have feedback systems with the circadian clock makes some sense to Hogenesch. (emaxhealth.com)
  • Hogenesch stresses that while the new experiments show a feedback loop between biological processes and the clock in individual cells in culture, it is not yet clear how feedback systems work in the whole organism. (emaxhealth.com)
  • New research provides a striking example of the importance of keeping the internal biological clock aligned with the external environment so that processes occur at the right time of day. (newswise.com)
  • When our activities and internal circadian clocks are out of step with the natural day-night cycle-for example, in cases of irregular shift work, jet lag and poor sleep-wake habits -we increase our risk of disease because of the mistiming of important biological processes. (newswise.com)
  • Falling PER protein levels at night causes our biological systems to slow: our blood pressure drops, our heart rate slows and our mental processes wind down. (scienceblog.com)
  • In addition to finding a new function for Cryptochrome, the results reinforce that notion that fruit flies provide an excellent model for understanding the human biological clock that drives sleep/wake cycles and many other processes that contribute to our overall health," said Blau. (innovations-report.com)
  • The circadian clocks that control and influence dozens of basic biological processes have an unexpected "snooze button" that helps cells adapt to changes in their environment. (bio-medicine.org)
  • Instead, the biological clock refers to the body's ability to time innate processes to the external environment, most notably the timing of light and darkness, temperature, and resource accessibility. (verywellhealth.com)
  • Cryptochrome is also regulates the biological clock in plants and animals. (emaxhealth.com)
  • Discover where the body's biological clock resides, how it regulates circadian patterns like sleep and wakefulness, and how disorders result when the timing of the clock becomes misaligned with the natural patterns of light and darkness. (verywellhealth.com)
  • We know that the biological clock regulates mood in humans. (vanderbilt.edu)
  • Sodium regulates clock time and output via an excitatory GABAergic pathway, Nature (2020). (medicalxpress.com)
  • They do so using the world's most important timekeepers: daily, or circadian, clocks that allow organisms to schedule their days so as not to be caught off guard by sunrise and sunset. (sciencenews.org)
  • Just as Rolex, Timex, Swatch and Seiko make their own versions of a wristwatch, organisms including cyanobacteria, fungi, plants and insects have all invented their own varieties of circadian clocks. (sciencenews.org)
  • There's no doubt that today's circadian clocks are must-have accessories for most organisms living on Earth's surface. (sciencenews.org)
  • Biological clocks underlie many of the biorhythms seen in organisms (e.g. hibernation in animals). (encyclopedia.com)
  • biological clock An endogenous, physiological mechanism, whose exact nature has not been determined, that keeps time independently of external events, enabling organisms to determine and to respond to daily, lunar, seasonal, and other periodicities. (encyclopedia.com)
  • This internal clock keeps the activity of everything , from single-celled organisms to humans, coordinated with the rotation of the planet and the cycles of day and night. (popsci.com)
  • All organisms that you choose to look at have got innate, endogenous biological clocks and those clocks are adjusted on a daily basis by light. (radionz.co.nz)
  • Answer: All biological organisms from single cells to whole organs from plants to animals, including humans, have, use and depend upon internal biological clocks to function normally. (gresham.ac.uk)
  • The aim has not been an all-embracing survey of experimental facts on the subject, but rather to emphasize the physiological kinship of phenomena having a wide variety of names, and to show thereby the great extent to which the physio- logical clock influences quite different phenomena in the "behaviour" of uni- cellular organisms, of higher plants, of animals, and of human beings. (springer.com)
  • This work shows how organisms can ignore the clock under certain circumstancesmuch like hitting a biological snooze button on the internal timepieceand enhance their survival in the face of ever-changing circumstances. (bio-medicine.org)
  • Therefore, the biological clock is the mechanism found within living organisms that coordinates the timing of physiological functions and behaviors to the natural day-night cycle. (verywellhealth.com)
  • For the most part, these analyses have been carried out using model organisms in standard laboratory housing, but to begin to understand the adaptive significance of the clock, we must expand our scope to study diverse animal species from different taxonomic groups, showing diverse activity patterns, in their natural environments. (royalsocietypublishing.org)
  • Since the dawn of life, most organisms have had to adapt to environmental cycles of light and darkness, and restrict many of their biological activities to specific times of day and night. (royalsocietypublishing.org)
  • Recently, oscillations in clock gene expression have been observed in tissues throughout the body, including lung, liver, and muscle, implying that clocks are in fact distributed throughout the body, synchronized by the master pacemaker in the SCN. (smith.edu)
  • Within each bacterium, the genetic machinery responsible for the biological clock oscillations was tied to green fluorescent protein, which caused the bacteria to periodically fluoresce. (medgadget.com)
  • The homodimeric, growth-related and time-keeping constitutive hydroquinone oxidase ENOX1 of the eukaryotic cell surface capable of oxidizing extracellular NAD(P)H and intracellular hydroquinones exhibits properties of the ultradian driver of the biological 24-h circadian clock by exhibiting a complex 2 + 3 set of oscillations with a period length of 24 min (repeats 60 times over 24 h). (springer.com)
  • That the oscillations result from physical rather than chemical events accounts for the temperature independence of the period length of clock-related phenomena. (springer.com)
  • An opportunity to link the ultradian ENOX oscillation to downstream activation of clock genes may be provided by responses of transcriptional factors to levels of NADH and especially to NAD + generated by ENOX oscillations. (springer.com)
  • And this tool of systems biology was the key to showing what makes a biological clock tick. (redorbit.com)
  • Experts agree that it is best to try to work with your natural body clock and biology, not against it, if possible. (medicinenet.com)
  • Published in the journal BMC Biology , these results show for the first time that directly targeting the biological clock in a cancerous tumour has an impact on its development. (eurekalert.org)
  • The article "Enhancing circadian clock function in cancer cells inhibits tumor growth" was published in the journal BMC Biology on February 14, 2017. (eurekalert.org)
  • I think this paper demonstrates the importance of having internal biological time coincide with environmental time," said UC San Diego Distinguished Professor Susan Golden, director of the Center for Circadian Biology and senior author of the paper. (newswise.com)
  • The body is essentially a collection of clocks," says Satchidananda Panda, an associate professor in Salk's Regulatory Biology Laboratory, who led the research along with Luciano DiTacchio, a post-doctoral research associate. (scienceblog.com)
  • The field of modern circadian biology got its start in the 1970s, when geneticist Seymour Benzer and his student Ron Konopka undertook a revolutionary study to track down the genes that encode biological timing in fruit flies. (theconversation.com)
  • Johnson's team performed the study with cyanobacteria (blue-green algae), the simplest organism known to possess a biological clock. (medindia.net)
  • The problem with this hypothesis was shown by Johnson and Rokas' study of the effect of changing codon usage on the simple biological clock found in single-celled cyanobacteria (blue-green algae) and a similar study of the more complex biological clock found in bread mold performed by a team led by Yi Liu that were published together. (bio-medicine.org)
  • The study found that when the biological clocks of cyanobacteria (blue-green algae) were stopped in their daylight setting, the amount of several biomolecules that they were genetically altered to produce increased by as much as 700 percent when grown in constant light. (nanowerk.com)
  • Throughout her career, she's found evidence that the parasite may manipulate the ants' behavior, in part, by hijacking their biological clocks. (eurekalert.org)
  • This biological clock seems to give the organism a sense of time as evidenced by a rhythmic pattern on its behavior. (biology-online.org)
  • Our biological clocks measure the day length and change our behavior according to the seasons. (vanderbilt.edu)
  • What is particularly striking about our results is the fact that the imprinting affects both the animal's behavior and the cycling of the neurons in the master biological clock in their brains," said Ciarleglio. (vanderbilt.edu)
  • The biological clocks and behavior of summer-born mice remain stable and aligned with the time of dusk while that of the winter-born mice varied widely when they were placed in a summer light cycle. (vanderbilt.edu)
  • Biological clock that synchronizes with biological rhythm may be endogenous or exogenous. (biology-online.org)
  • An endogenous type is one in which the internal biological clock is the one that controls it. (biology-online.org)
  • The pacemaker works as a clock because its endogenous period is adjusted to the external 24 h period, primarily by light-induced phase shifts that reset the pacemaker's oscillation. (royalsocietypublishing.org)
  • Variations in photic sensitivity, in concert with changes in the pacemaker's endogenous period and amplitude, can dramatically affect the phase of entrainment of clock-controlled events. (royalsocietypublishing.org)
  • Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. (biomedsearch.com)
  • Drosophila larvae were the lab subject for the early circadian clock research. (theconversation.com)
  • Because Drosophila pupae emerge only at a specific time of the day, Konopka could measure the timing between rounds of eclosion for different strains of flies and identify those that had a bad clock. (theconversation.com)
  • In Drosophila, newly synthesized CLOCK (CLK) is hypophosphorylated in the cytoplasm before entering the nucleus. (wikipedia.org)
  • This cycle of post-translational phosphorylation suggest that temporal phosphorylation of CLK helps in the timing mechanism of the circadian clock. (wikipedia.org)
  • LIFE'S CYCLES Throughout the human body, circadian clocks keep activities running on a daily schedule of day and night. (sciencenews.org)
  • Just as they rely on the clockmaker adjusting and resetting them to maintain accuracy, so our biological clocks rely on external zeitgebers (particularly light/dark cycles) to do this. (gresham.ac.uk)
  • The biological clock also appears important to the development of disease, most likely due to its daily influence over metabolic cycles. (scienceblog.com)
  • They found that Cryptochrome interacts with a particular section of BMAL1, and that mutations causing structural changes in that section can alter the timing of the clock, resulting in cycles as short as 19 hours or as long as 26 hours. (fiercebiotech.com)
  • Seasonal Affective Disorder, some types of depression, sleep disorders and problems adjusting to changes in work cycles all can occur when an individual's biological clock acts up. (science20.com)
  • When forced to operate in a 24-hour daily light/dark cycles, the bacteria with the optimized clock grew significantly slower than "wild-type" cells. (bio-medicine.org)
  • The connections make the clock precise but also let it adjust to changes in day/night cycles. (kurzweilai.net)
  • We have discovered that temperature cycles modulate the rhythmic expression of a protein called CIRP, and that this molecule is required for a robust activation of clock genes on a daily basis', says Jörg Morf, researcher at the NCCR Frontiers in Genetics and first author of the article. (phys.org)
  • Regular 24-hour cycles of day and night on Earth led to the evolution of biological clocks that reside within our cells. (theconversation.com)
  • Experts believe learning how the human biological clock works is an essential step toward correcting sleep problems like insomnia and jet lag. (psychcentral.com)
  • Since humans are fundamentally diurnal creatures, staying awake at night can significantly disrupt all of the body's internal biological clocks. (science20.com)
  • The tick-tock of your biological clock may have just gotten a little louder. (redorbit.com)
  • The biological clock ramps up our metabolism early each day, initiating important physiological functions that tell our bodies that it's time to rise and shine. (scienceblog.com)
  • The most obvious reason is the odd hours throw a person's 24-hour biological clock-and metabolism-out of sync. (georgetown.edu)
  • The key role that Clock plays in metabolic and circadian loops highlights the close relationship between metabolism and circadian clocks. (wikipedia.org)
  • Fisch, author of the book "The Male Biological Clock: The Startling News About Aging, Sexuality, and Fertility in Men," said he thinks that what Hudson and other men are doing "may be excessive. (cnn.com)
  • We know that women have a biological time clock, with an increase in risk of miscarriage and producing children with trisomy-an extra chromosome, such as in Down's syndrome-as women age, and with a seemingly abrupt end of fertility around perimenopause," added Brenda Eskenazi, Ph.D., of the University of California at Berkeley School of Public Health, a co-author. (medpagetoday.com)
  • In reality we know that men are not immune to the biological effects of ageing, but it is far less discussed than the effects of age on women's fertility,' she said. (brisbanetimes.com.au)
  • And lately I've been thinking about how ladies are basically required to find love and settle down and have a career at an earlier stage than guys are because their biological clocks mean that fertility/the chances of having healthy babies decline after the age of 35. (metafilter.com)
  • Biological clock may also pertain to female fertility wherein there is a gradual decrease of fertility from puberty to menopause. (biology-online.org)
  • First Gene Therapy Successful Against Aging-Associated Decline: Mouse Lifespan Extended Up to 24% With a Single Treatment A new study consisting of inducing cells to express telomerase, the enzyme which -- metaphorically -- slows down the biological clock -- was successful. (metafilter.com)
  • KL001 slows down the biological clock because it stops crypotochrome from being sent to the proteasomes - protein complexes that degrade damaged cellular material. (emaxhealth.com)
  • These studies in fruit flies have allowed the identification of similar "clock genes" in mammals, which function in a similar manner in mammals as they do in a fly s clock. (innovations-report.com)
  • In fruit flies, Cry is a circadian photoreceptor, which helps light reset the biological clock with changing seasons, or in jet lag-style experiments (in which light is manipulated to mimic the experience of traveling over multiple time zones) in the lab. (innovations-report.com)
  • The NYU and London studies of fruit flies have allowed the identification of "clock genes" in mammals, which function in a similar manner in mammals as they do in a fly's clock. (phys.org)
  • In fruit flies, Cry is a circadian photoreceptor, which helps light reset the biological clock with changing seasons. (phys.org)
  • The husband-and-wife team has discovered a protein that is responsible for setting the length of periods of activity and inactivity within cells in the body, acting as a biological clock. (innovations-report.com)
  • To confirm that the protein was responsible not just for regulating growth but for all activities set by the biological clock, Pin-Ju Chueh, then a microbiology graduate student in Dorothy Morré s lab, isolated the gene which produced the protein within cells. (innovations-report.com)
  • The central player of our biological clock is a protein called PERIOD (PER). (scienceblog.com)
  • As the level of PER protein rises during the daytime, reaching its peak around evening, it somehow puts a break on CLOCK and BMAL, thereby reducing its own level during nighttime. (scienceblog.com)
  • Their studies suggest that what gut microbes "say" influences the activity of a key clock-driven protein called NFIL3, which can set intestinal cells up to absorb and store more fat from the diet while operating at hours that might run counter to our fixed biological clocks. (georgetown.edu)
  • We examined the neural organization of the suprachiasmatic nucleus (SCN) through time-lapse imaging of a short-half-life green fluorescent protein (GFP) reporter of the circadian clock gene Period 1 ( Per1 ). (jneurosci.org)
  • This gene causes the manufacture of a transcription factor-the CLOCK protein-that binds to a strand of DNA on another gene to transcribe copies of it in the form of messenger RNA. (mcgill.ca)
  • In mice, the CLOCK protein binds to and thus activates the per gene. (mcgill.ca)
  • CLOCK protein has been found to play a central role as a transcription factor in the circadian pacemaker. (wikipedia.org)
  • The CLOCK-BMAL dimer activates transcription of the Nampt gene, which codes for the NAMPT protein. (wikipedia.org)
  • This suppression results in less transcription of the NAMPT, less NAMPT protein, less NAD made, and therefore less SIRT1 and less suppression of the CLOCK-BMAL dimer. (wikipedia.org)
  • The team determined that polyamine levels in elderly mice drop at the same time their circadian clocks start slowing down. (acs.org)
  • Feeding animals the supplement restored their circadian clocks to the timing of younger mice. (acs.org)
  • Mice and canids split 80 million years ago, so the rDNA clock is ancient. (plos.org)
  • A new study from McGill University shows that increases in the concentrations of blood sodium can have an influence on the biological clock of mice, opening new research avenues for potentially treating the negative effects associated with long distance travel or shift work. (medicalxpress.com)
  • The findings, published in Nature by former McGill Ph.D. student Claire Gizowski and Charles Bourque, a professor in McGill's Department of Neurology-Neurosurgery, are the first to show that injecting mice with a salt solution leads to the activation of neurons associated with the brain's master circadian clock-the suprachiasmatic nucleus (SCN). (medicalxpress.com)
  • In 1997, U.S. neurobiologist Joseph Takahashi and his team provided part of the answer when they discovered the clock gene in mice. (mcgill.ca)
  • A similar model is found in mice, in which BMAL1 dimerizes with CLOCK to activate per and cryptochrome (cry) transcription. (wikipedia.org)
  • The binding of CLOCK-BMAL to an E-box promoter element activates transcription of clock genes such as per1, 2, and 3 and tim in mice. (wikipedia.org)
  • It has been shown in mice that CLOCK-BMAL also activates the Nicotinamide phosphoribosyltransferase gene (also called Nampt), part of a separate feedback loop. (wikipedia.org)
  • The "clock" inside each SCN neuron depends on the cyclic expression of a family of genes such as the Period (PER) genes. (kurzweilai.net)
  • and have tested the effects of cyclic light input on the temporal organization of the clock nucleus. (jneurosci.org)
  • Most of our body's cells possess one of them, formed by a group of 'clock genes' displaying a cyclic activity that peaks every twenty-four hours. (phys.org)
  • Most of our cells possess an internal clock, a group of genes displaying a cyclic expression pattern that reaches a peak once a day. (phys.org)
  • A compound that makes the clock slow down or speed up can also be used to phase-shift the clock - in other words, to bump or reset the hands of the clock. (redorbit.com)
  • The finding, published online in the journal Science, means an entirely new way for treating type 2 diabetes and possibly other metabolic diseases like obesity with drugs that reset the biological clock. (emaxhealth.com)
  • But, he says, since this biological "reset button" evolved long before mechanical clocks, artificial lights, and high-speed travel, it doesn't introduce enough jitter to allow us to adjust quickly to the extreme time shifts of modern life, such as flying "backward" (east) through several time zones. (kurzweilai.net)
  • How does body temperature reset the biological clock? (phys.org)
  • A master clock in the human brain appears to synchronize sleep and wake with light. (sciencenews.org)
  • In 2005 they reported that the neurons in the clock network communicate by means of a neuropeptide (vasoactive intestinal polypeptide, or VIP) that pushes them to synchronize with one another. (kurzweilai.net)
  • Together these two networks (VIP and GABA) ensure the clock runs as coordinated, precise timepiece, but one that can still adjust its timing to synchronize with the environment. (kurzweilai.net)
  • If the SCN as a whole is to function as a clock, its neurons need to synchronize with one another. (kurzweilai.net)
  • Clocks in organ tissues synchronize with the central clock. (films.com)
  • it is easier to synchronize the body clock flying west. (films.com)
  • These results indicated that Cry normally inhibits clock gene expression in many clock cells - just as it does in the mammalian clock. (innovations-report.com)
  • The circadian clock nucleus of the mammalian brain is composed of thousands of oscillator neurons, each driven by the cell-autonomous action of a defined set of circadian clock genes. (jneurosci.org)
  • Physiological "dissection" of the mammalian biological clock (R. Silver, M.-T. Romero, J. LeSauter) Non-SCN rhythm in the circadian domain (K. Honma, S. Honma). (nhbs.com)
  • That showed that "intact Clock genes" are necessary for normal mammalian circadian function[how? (wikipedia.org)
  • Moreover, taking a simpler model, we demonstrate the generality of the proposed compensation mechanism, suggesting relevance not only to circadian clocks but to other (bio)chemical oscillators as well. (pnas.org)
  • The master clock also controls coordination signals that are sent to subsidiary oscillators. (phys.org)
  • The master clock is an area called the suprachiasmatic nucleus , a small region of the brain found within the anterior hypothalamus . (verywellhealth.com)
  • Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. (biomedsearch.com)
  • The paper, published this week in the journal Aging , explains how a higher biological age - regardless of chronological age - predicts an earlier death. (medicalnewstoday.com)
  • It's almost as if when we have an infection, the alarm in the macrophage clock goes off," explains co-first author Annie Curtis, PhD, senior research fellow Trinity College. (medicalnewstoday.com)
  • Bancroft explains the Clock gene's dysfunction in bipolar disease. (films.com)
  • This suggests that there could be ways by which we could speed up the clock, which could be useful to adapt more quickly to the time change associated with long distance travel , or when our work schedule is shifted by several hours," explains Gizowski. (medicalxpress.com)
  • The team's new discoveries about the extent of genes under the control of the biological clock and the utility of Computing Life came from studying genes in Neurospora crassa""bread mold. (redorbit.com)
  • Then they recorded electrical signals produced exclusively by those clock cells. (psychcentral.com)
  • And during the day, when we're active, our biological clock shuts down those fasting signals that tell our liver to make more glucose because that's when we're eating. (emaxhealth.com)
  • Animal studies have shown that our central clock (in the brain) sends signals to the clocks in our other organs. (science20.com)
  • We were curious to see if light signals could shape the development of the biological clock," said McMahon. (vanderbilt.edu)
  • Is your biological clock ticking? (bellaonline.com)
  • How they work to keep the biological clock ticking is amazing! (apologeticspress.org)
  • Today in Your Health, we'll listen to the ticking of your biological clock. (npr.org)
  • In short our bodies resemble the classic nightmare shop full of ticking and chiming clocks which only stop when you, or individual cells in your body, die. (gresham.ac.uk)
  • I hired a dating service for 10K, (which at the time was the best way to deal with my ticking clock) and the guys who were coming up were great investors for my company and lousy husband prospects. (penelopetrunk.com)
  • Still, I wasn't thrilled to receive yet another reminder that my biological clock is ticking. (thoughtcatalog.com)
  • Deeper implications will be explored through modeling the circadian clock as a dynamical system using differential equations. (smith.edu)
  • The SCN contains both clock cells (which express a gene called per1) and non-clock cells. (psychcentral.com)
  • But Forger's British colleagues were able to separate clock cells from non-clock cells by zeroing in on the ones that expressed the per1 gene. (psychcentral.com)
  • The old theory was that the cells in the SCN which contain the clock are firing fast during the day but slow at night. (psychcentral.com)
  • But now we've shown that the cells that actually contain the clock mechanism are silent during the day, when everybody thought they were firing fast," Diekman said. (psychcentral.com)
  • The robot was programmed to isolate the molecules that showed the greatest effects on the cells' biological clocks. (redorbit.com)
  • TUREK: Yes, there are clocks in all the cells of your body. (npr.org)
  • Does the biological clock in cancer cells influence tumour growth? (eurekalert.org)
  • Most of the cells in the human body have an internal clock that sets a rhythm for the activities of our organs according to the time of the day. (eurekalert.org)
  • Cancer cells, however, often have a non-functioning or malfunctioning clock. (eurekalert.org)
  • Thanks to the use of a chemical or a thermic treatment, we succeeded in 'repairing' these cells' clock and restoring it to its normal functioning. (eurekalert.org)
  • This was done by attaching in the cells a clock gene to a luciferase gene used by fireflies to glow at night, so that the cells glowed when the biological clock was activated. (scienceblog.com)
  • They found that when darkness occurs at the time the cells' internal clock tells them it's dusk, DNA uptake and incorporation increase dramatically. (newswise.com)
  • They treated mouse cells with a drug that mimics JARID1a, which allowed their biological clocks to operate normally. (scienceblog.com)
  • The best-studied measure of biological age is the shrinking of chromosome tips, or telomeres, that do so with each division of most types of cells. (plos.org)
  • KL001 was accidentally discovered when Tsuyoshi Hirota, a postdoctoral fellow in Kay's laboratory isolated a compound called "longdaysin" that lengthens it the daily biological clocks of human cells by more than 10 hours. (emaxhealth.com)
  • These results show, for the first time, that the peripheral biological clocks located in white blood cells can be synchronized through the administration of glucocorticoid tablets. (science20.com)
  • We studied the rhythmic expression of clock genes in white blood cells to see how they adjusted in response to glucocorticoids. (science20.com)
  • This wiring uses the GABA (γ-amino-butyric acid) neurotransmitter to connect the individual cells of the biological clock in a fast network that changes strength with time of day. (kurzweilai.net)
  • The goal of the recent work in the Herzog lab has been to figure out how the clock cells are connected to each other. (kurzweilai.net)
  • They found that the cells with the locked clocks produced 200 percent more hydrogenase, 500 percent more insulin and 700 percent more luciferase when grown in constant light than they did when the genes were inserted in cells with normally functioning clocks. (nanowerk.com)
  • To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation, Cermakian's team compared growth and cell cycle events of B16 melanoma cells and tumors with either a functional or dysfunctional clock. (cancertutor.com)
  • For this study, Silke Kiessling, a postdoctoral fellow on Cermakian's team, successfully adjusted the gears of the internal clocks in two types of cancer cells - skin and colon - to make them function properly. (cancertutor.com)
  • 2017). Enhancing circadian clock function in cancer cells inhibits tumor growth. (cancertutor.com)
  • 26] A Virginia Commonwealth University researcher has developed a procedure for identifying the source of cells present in a forensic biological sample that could change how cell types are identified in samples across numerous industries. (vixra.org)
  • In mammals, however, Cry assists in the 24-hour rhythmic expression of clock genes and has nothing to do with re-setting the clock. (innovations-report.com)
  • Graduate student Chris Ciarleglio who performed the study in the McMahon Lab that found the circadian clock in mammals is imprinted by the day/night cycle when an individual is born. (vanderbilt.edu)
  • Jet lag occurs when you travel to different time zones, but your body clock is still on the schedule of the time zone where you normally live. (medicinenet.com)
  • the reply would most certainly be "No." Clocks are complex instruments designed to accurately and repeatedly keep time to the millisecond. (apologeticspress.org)
  • In a physical clock or watch, a system of gears and shafts are designed to keep the clock moving, keeping precise, accurate time. (apologeticspress.org)
  • And then when they try to go to sleep, their body clock is saying, hey, time to get up. (npr.org)
  • Our research suggests that men, too, have a biological time clock-only it is different," she added. (medpagetoday.com)
  • As time passed, it also became clear that astronauts suffered bone loss and muscle wastage due, in part, to space travel s effects on their internal clocks, and air travelers began experiencing the clock-related ailment of jet lag. (innovations-report.com)
  • Morré spent time on other projects, but the biological clock never escaped his mind or efforts completely. (innovations-report.com)
  • As humans we live in a world where time can be measured by atomic clocks to accuracies in nanoseconds across millennia. (gresham.ac.uk)
  • Question: With all these external zeitgebers (time-givers) to provide us with accurate time information is there any need to have a biological clock? (gresham.ac.uk)
  • However, a similar understanding of what controls biological time and time perception by complex nervous systems is equally fascinating. (gresham.ac.uk)
  • This lecture will therefore focus on revealing the nature and location of our biological clocks and then consider how we and other species may perceive, use and even experience time. (gresham.ac.uk)
  • Furthennore, an attempt has been made to make as thorough an analysis of the mechanism of the clock as is possible at the present time. (springer.com)
  • However, he added "when inflammation is present for long periods of time, as is the case for patients with a chronic disease like rheumatoid arthritis , this constant targeting of the clock may actually worsen disease. (medicalnewstoday.com)
  • We have known for a long time that the immune system and body clock are interconnected, with our immune system responding differently to bacteria depending on the time of day. (medicalnewstoday.com)
  • In the cyanobacterium it makes a very big difference for biological time and external environment time to be aligned. (newswise.com)
  • In contrast, darkness at times that do not match the internal clock time fails to provide a boost in DNA uptake and incorporation. (newswise.com)
  • But measuring biological aging isn't as easy as noting the passage of time. (plos.org)
  • The coolest part is that a simple biological machine can do such an astounding thing as keeping time," says Williams. (science20.com)
  • The first hint that the fungal parasite may hijack the ants' biological clock came from field studies that observed infected ants all actively searched for an elevated piece of vegetation to bite down on at the same time of day. (eurekalert.org)
  • These clocks help us unconsciously pick the best time to rest, search for food, or anticipate danger or predation. (theconversation.com)
  • If you just imagine how a biological clock might best keep track of time over a day, you might jump to a mental picture of an hourglass timer. (theconversation.com)
  • Was PER the substance that kept biological time by gradually changing throughout the day? (theconversation.com)
  • because they need to know along wat directions they are flying according to the position of the sun.therefore, they have to know at wat time wat position the sun would be found.this is done by using an internal clock. (biology-online.org)
  • Biological clock is commonly used to apply to women, who of course do have a more limited time to reproduce than men do. (thethinkingatheist.com)
  • This strategy disconnected the biological pacemaker from clock time. (harvard.edu)
  • According to a study conducted by Nicolas Cermakian, a professor in McGill University's Department of Psychiatry, the results show for the first time that directly targeting the biological clock in a cancerous tumor has an impact on its development. (cancertutor.com)
  • A creature's biological clock controls the time at which it is active or asleep. (sciencephoto.com)
  • Gizowski and Bourque were able to show that salt-sensitive neurons found in a specific region of the brain-the organum vasculosum of the lamina terminalis-are capable of activating the brain's master circadian clock at a time of day when it is normally silent. (medicalxpress.com)
  • In both cases, they found that the clock had stopped - with high levels of clock gene expression when Cry was mutated, and low levels when Cry was over-produced. (innovations-report.com)
  • All levels of biological organization within an organism, from gene expression to immune function, behaviour and seasonal patterns of reproduction are subject to regulation by the clock [ 1 ]. (royalsocietypublishing.org)
  • The biological clock in a much-studied model organism is dramatically higher than previously reported. (redorbit.com)
  • This new finding may help to explain why the clock is so far-reaching in its effects on the organism," said Jonathan Arnold, a professor in the UGA department of genetics and director of the research project. (redorbit.com)
  • We found that some 25 percent of the genes in our model organism appear to be under clock control. (redorbit.com)
  • A new study has provided direct evidence that biological clocks can influence the activity of a large number of different genes in an ingenious fashion, just by causing chromosomes to coil more tightly during the day and to relax at night. (medindia.net)
  • This study illustrates the important role of the body clock in the immune response and provides a new rationale for a broad array of therapies. (medicalnewstoday.com)
  • Professor Andrew Shennan, an expert in obstetrics for Tommy's, said the study was interesting, 'As a result of this research the potential benefit of reducing unnecessary light exposure must now be investigated, as it would seem that there is a strong possibility that this could improve the development of the body clock. (medindia.net)
  • A small study may open new therapeutic avenues for improving the synchronization of the body's different biological clocks. (science20.com)
  • To begin to understand the functional significance of the clock and the selection pressures at the evolutionary scale that have shaped patterns of animal rhythmicity, we must expand our scope to study diverse animal species from different taxonomic groups showing diverse activity patterns and in their natural environments, with, for example, changing temperature and humidity, limited resources, cooperation or competition from conspecifics and the presence of predators. (royalsocietypublishing.org)
  • AUBREY: Now, the master clock in our brains is like the symphony conductor keeping all of the players in sync. (npr.org)
  • Most people know that our biological functions use a circadian system comprised of a central clock located deep within the center of our brains and multiple clocks located in different parts of the body. (science20.com)
  • And that's just one example among many of the troubles we cause ourselves when we override the biological clocks in our brains and pay attention instead to the mechanical clocks on our wrists. (kurzweilai.net)
  • Kelsey Hubbard talks to the author about the role a man's biological clock plays in a child's risk for diseases and disorders. (wsj.com)
  • The new insights about the body's central pacemaker might also, someday, advance efforts to treat diseases influenced by the internal clock, including cancer , Alzheimer's disease and mood disorders, said University of Michigan mathematician Daniel Forger. (psychcentral.com)
  • He also studies the consequences of dysfunctional clocks on health including psychiatric disorders, infectious diseases and cancer. (eurekalert.org)
  • For example, approaches that restore clock function in treating inflammatory disorders and, perhaps attacking cancers at certain times of the day, may benefit from understanding this complex system of control. (medicalnewstoday.com)
  • Our objectives are to define the scope and problems related to biological clock disorders in children with ONH and to develop effective treatments for this condition. (clinicaltrials.gov)
  • By understanding what makes the clock tick and how it is regulated, we may be able to identify points where we can intervene pharmacologically to treat disorders in which the clock is disrupted,' she said. (fiercebiotech.com)
  • New work is shedding light on the origin and evolution of biological clocks. (sciencenews.org)
  • The thing about sperm is that they're freshly made on a regular basis - which is one reason why the male biological clock doesn't tick as loudly, or grind to a halt as finitely, as the female's. (kidspot.com.au)
  • The first scientific investigations trying to establish the presence of internal biological clocks seem to have been made by the French astronomer de Mairan in 1729. (gresham.ac.uk)
  • We knew since the 1990s that some bacteria have clocks. (plos.org)
  • Many of our physiological functions, such as heart beat frequency, hormone secretion or body temperature, are regulated by internal clocks . (phys.org)
  • The new research, just published in the Public Library of Science One, also shows how Arnold's team used a new methodology called Computing Life to yield these new discoveries about biological clocks. (redorbit.com)
  • Before the current research, only 16 clock-controlled genes had been discovered in Neurospora in more than 40 years of research. (redorbit.com)
  • New research suggests that timing herbicide application to the biological clocks of plants may improve both its efficacy and crop production. (upi.com)
  • This proof of concept research suggests that, in future, we might be able to refine the use of some chemicals that are used in agriculture by taking advantage of the biological clock in plants," Dodd said in a press release. (upi.com)
  • Also, high quality research contributions describing original and unpublished results of conceptual, constructive, empirical, experimental, or theoretical work in all areas of Biological Clocks and Evolution are cordially invited for presentation at the conference. (waset.org)
  • The new biological ticker, the rDNA clock, makes its debut in the latest issue of Genome Research . (plos.org)
  • Also, high quality research contributions describing original and unpublished results of conceptual, constructive, empirical, experimental, or theoretical work in all areas of Biological Clocks and Immune System are cordially invited for presentation at the conference. (waset.org)
  • At Vanderbilt, Research Associate Professor Yao Xu optimized the codons in the cyanobacteria's biological clock. (bio-medicine.org)
  • In her latest research published Nov. 3 in the peer-review journal Plos One , findings show that the parasite itself has a working biological clock, too, that may be the driving force behind the timing of when and how the parasite infects and manipulates the ants. (eurekalert.org)
  • De Bekker and her team, which consists of UCF undergraduate and graduate students, now plan to further this new avenue of research to hopefully one day better understand how biological clocks are disturbed by parasites. (eurekalert.org)
  • Our results provide a mechanistic foundation to understand the essentially universal role of CK1 as a regulator of eukaryotic circadian clocks,' Partch said. (news-medical.net)
  • According to Carrie Partch, a professor of chemistry and biochemistry at UC Santa Cruz and corresponding author of the paper, the connection between clock disruption and cancer is still unclear. (fiercebiotech.com)
  • Beyond its role in cancer, Partch is also interested in understanding the normal role of PASD1 and why it is silencing the clock in the human germ line. (fiercebiotech.com)
  • Partch and her colleagues found that PASD1 is structurally related to CLOCK and interferes with the function of the CLOCK-BMAL1 complex. (fiercebiotech.com)
  • It shuts the clock off very efficiently,' Partch said. (fiercebiotech.com)
  • If we can control this process with small molecules, we can affect the timing of the clock,' Partch said. (fiercebiotech.com)
  • Longdaysin is the champion by far in how much it can move the clock," said Kay, whose laboratory at UCSD had found compounds in previous studies that could shift the biological clock by as much as several hours at most. (scienceblog.com)
  • We were really encouraged to find that when we added longdaysin to these living zebra fish, we lengthened the biological clock and didn't see any obvious deleterious effects," said Kay. (scienceblog.com)
  • The body clock undergoes many changes as a person ages. (medicinenet.com)
  • When your body clock is off, your whole system suffers. (medicinenet.com)
  • When their body clock is telling them to go to sleep, they have to be awake. (npr.org)
  • An important link between the human body clock and the immune system has relevance for better understanding inflammatory and infectious diseases, discovered collaborators at the Perelman School of Medicine at the University of Pennsylvania and Trinity College, Dublin. (medicalnewstoday.com)
  • Your internal body clock is what makes you wake up in the morning and go to sleep at night disruption to your internal body clock can affect your sleeping pattern leading to a reduced amount of sleep which affects mental and physical wellbeing. (simplyled.co.uk)
  • Their sleep pattern shifted by seven hours each week, but their body clock only shifted by two hours. (films.com)
  • By recording age-related changes to human DNA and calculating an individual's biological age, the team found that they could accurately estimate someone's lifespan. (medicalnewstoday.com)
  • the team found that by comparing an individual's chronological age with their blood's biological age, they could predict life expectancy. (medicalnewstoday.com)
  • In earlier experiments, his team used honey bees and other animal models, and found that when bees are given a general anaesthetic, their clocks shifts and they, too, experience jet lag. (radionz.co.nz)
  • Did your biological clock go off when you were in your 30s, had hit the ceiling in your career, found the perfect partner, and wanted to share that love with a baby? (yourtango.com)
  • A chemical robot screened more than 120,000 potential compounds from a chemical library into individual micro-titer wells, a system used by drug companies called high-throughput screening, and automatically singled out those molecules found to have the biggest effects on the biological clock. (scienceblog.com)
  • A fresh example supporting the old saying has been found in connection with the systems regulated by biological clocks. (newswise.com)
  • Schuttler and Arnold found a stunning 295 genes that are influenced by the clock. (medgadget.com)
  • Now that we've found it, we can explore more deeply how our biological clocks malfunction as we get older and develop chronic illness. (scienceblog.com)
  • What the Liu team found was that optimizing all the codons used by the fungal biological clock knocked the clock out, which was totally unexpected! (bio-medicine.org)
  • Subsequent work mapped the entire clock mechanism in cyanobacteria, which is the simplest bioclock found in nature. (nanowerk.com)
  • In addition, their experiments found that the imprinting of clock gene activity near birth had dramatic effects on the reaction of the biological clock to changes in season later in life. (vanderbilt.edu)
  • Kay's team has been working on finding molecules that lengthen the biological clock for 20 years. (emaxhealth.com)
  • However, these results lead us to believe that we may one day be able to use a combined therapy that targets the central clock (inverting work schedules, administering controlled light therapy) with a pharmacological treatment that targets the peripheral clocks to ensure that all clocks are adjusted. (science20.com)
  • Changing meal times uncouples peripheral clocks from the central clock by twelve hours. (films.com)
  • It exerts hormonal control to peripheral clocks that have been described in many cell types, including everything from heart to liver to fat tissues. (verywellhealth.com)
  • Activating the biological clock in tumours could become an innovative approach in slowing their growth or that of metastases. (eurekalert.org)
  • Pituitary adenylate cyclase activating peptide (PACAP) in the retinohypothalamic tract phase shifts the circadian clock (J.D. Mikkelsen et al. (nhbs.com)