AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Biological AvailabilityBiopharmaceuticsAuthorshipKnowledge BasesEditorial PoliciesScientific MisconductPublishingAluminumDiatomsSiliconGallionellaceaeSilicic AcidPhosphorusOligochaetaPolycyclic Hydrocarbons, AromaticSoil PollutantsSoilDrugs, EssentialSoil MicrobiologyIndustryGraphiteNanostructuresNanotechnologyTitaniumNanocompositesAccess to InformationPlasmaTasmaniaComputer SimulationResearchModels, BiologicalAlgorithmsRegression AnalysisModels, TheoreticalChemical TerrorismTerrorismVariola virusEmergency RespondersStrategic StockpileChemical WarfarePublic Health Administration
Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Biopharmaceutics: The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.Diatoms: The common name for the phylum of microscopic unicellular STRAMENOPILES. Most are aquatic, being found in fresh, brackish, and salt water. Diatoms are noted for the symmetry and sculpturing of their siliceous cell walls. They account for 40% of PHYTOPLANKTON, but not all diatoms are planktonic.Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Gallionellaceae: A family of gram-negative bacteria in the order Nitrosomonadales, class BETAPROTEOBACTERIA. It contains a single genus Gallionella.Silicic Acid: A hydrated form of silicon dioxide. It is commonly used in the manufacture of TOOTHPASTES and as a stationary phase for CHROMATOGRAPHY.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Oligochaeta: A class of annelid worms with few setae per segment. It includes the earthworms such as Lumbricus and Eisenia.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Soil Pollutants: Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.Soil: The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.Drugs, Essential: Drugs considered essential to meet the health needs of a population as well as to control drug costs.Soil Microbiology: The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.Industry: Any enterprise centered on the processing, assembly, production, or marketing of a line of products, services, commodities, or merchandise, in a particular field often named after its principal product. Examples include the automobile, fishing, music, publishing, insurance, and textile industries.Graphite: An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)Nanocomposites: Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)Access to Information: Individual's rights to obtain and use information collected or generated by others.Plasma: The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.Tasmania: An island south of Australia and the smallest state of the Commonwealth. Its capital is Hobart. It was discovered and named Van Diemen's Island in 1642 by Abel Tasman, a Dutch navigator, in honor of the Dutch governor-general of the Dutch East Indian colonies. It was renamed for the discoverer in 1853. In 1803 it was taken over by Great Britain and was used as a penal colony. It was granted government in 1856 and federated as a state in 1901. (From Webster's New Geographical Dictionary, 1988, p1190 & Room, Brewer's Dictionary of Names, p535)Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Chemical Terrorism: The use of chemical agents in TERRORISM. This includes the malevolent use of nerve agents, blood agents, blister agents, and choking agents (NOXAE).Terrorism: The use or threatened use of force or violence against persons or property in violation of criminal laws for purposes of intimidation, coercion, or ransom, in support of political or social objectives.Variola virus: A species of ORTHOPOXVIRUS causing infections in humans. No infections have been reported since 1977 and the virus is now believed to be virtually extinct.Emergency Responders: Personnel trained to provide the initial services, care, and support in EMERGENCIES or DISASTERS.Strategic Stockpile: Planned and coordinated pre-event accumulation of ESSENTIAL DRUGS and medical supplies.Chemical Warfare: Tactical warfare using incendiary mixtures, smokes, or irritant, burning, or asphyxiating gases.Public Health Administration: Management of public health organizations or agencies.

Advanced analysis of biotin metabolites in body fluids allows a more accurate measurement of biotin bioavailability and metabolism in humans. (1/3985)

In previous studies, the bioavailability of biotin in humans was estimated from the recovery of biotin in urine; urinary biotin was measured by microbial growth assays or assays of avidin-binding activity. These assays underestimate concentrations of biotin metabolites, which originate from beta-oxidation, sulfur oxidation or a combination. We have developed an HPLC/avidin-binding assay that is specific for biotin and its metabolites. With the use of the HPLC/avidin-binding assay, TLC and derivatization with p-dimethylaminocinnamaldehyde, we have identified and quantitated biotin and metabolites in urine from six healthy adults. Of that total, biotin accounted for 32+/-12%, bisnorbiotin for 52+/-15%, bisnorbiotin methyl ketone for 7.9+/-5.8%, biotin-d,l-sulfoxide for 4.0+/-3.2% and biotin sulfone for 3.6+/-1.9%. After intravenous administration of 18.4 micromol of biotin, the urinary excretion of biotin metabolites increased 21-130 times above baseline values. Because the biliary excretion of biotin is quantitatively minor (1.9+/-0.2% of an intravenous [14C]biotin dose in rats), intravenously administered biotin is not exposed to intestinal microorganisms. Thus we conclude that biotin metabolites in human urine originate from biotin catabolism in human tissues rather than biotin catabolism by intestinal microorganisms. With the use of the HPLC/avidin-binding assay, we estimated the bioavailability of biotin in adults from the urinary excretion of biotin and metabolites after ingestion of 2.1, 8.2 and 81.9 micromol of biotin. These data provide evidence that biotin is nearly completely absorbed.  (+info)

The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle. (2/3985)

No studies have singularly investigated the relationship between pyruvate availability, pyruvate dehydrogenase complex (PDC) activation, and anaplerosis in skeletal muscle. This is surprising given the functional importance attributed to these processes in normal and disease states. We investigated the effects of changing pyruvate availability with dichloroacetate (DCA), epinephrine, and pyruvate infusions on PDC activation and accumulation of acetyl groups and tricarboxylic acid (TCA) cycle intermediates (TCAI) in human muscle. DCA increased resting PDC activity sixfold (P < 0.05) but decreased the muscle TCAI pool (mmol/kg dry muscle) from 1.174 +/- 0.042 to 0.747 +/- 0.055 (P < 0.05). This was probably a result of pyruvate being diverted to acetyl-CoA and acetylcarnitine after near-maximal activation of PDC by DCA. Conversely, neither epinephrine nor pyruvate activated PDC. However, both increased the TCAI pool (1.128 +/- 0.076 to 1.614 +/- 0.188, P < 0.05 and 1.098 +/- 0.059 to 1.385 +/- 0.114, P < 0.05, respectively) by providing a readily available pool of pyruvate for anaplerosis. These data support the hypothesis that TCAI pool expansion is principally a reflection of increased muscle pyruvate availability and, together with our previous work (J. A. Timmons, S. M. Poucher, D. Constantin-Teodosiu, V. Worrall, I. A. Macdonald, and P. L. Greenhaff. J. Clin. Invest. 97: 879-883, 1996), indicate that TCA cycle expansion may be of little functional significance to TCA cycle flux. It would appear therefore that the primary effect of DCA on oxidative ATP provision is to provide a readily available pool of acetyl groups to the TCA cycle at the onset of exercise rather than increasing TCA cycle flux by expanding the TCAI pool.  (+info)

Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations. (3/3985)

High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced stage subcutaneous paediatric solid tumour xenografts. Because busulphan is highly insoluble in water, the use of several vehicles for enteral and parenteral administration was first investigated in terms of pharmacokinetics and toxicity. The highest bioavailability was obtained with busulphan in DMSO administered i.p. When busulphan was suspended in carboxymethylcellulose and given orally or i.p., the bioavailability was poor. Then, in the therapeutic experiments, busulphan in DMSO was administered i.p. on days 0 and 4. At the maximum tolerated total dose (50 mg kg(-1)), busulphan induced a significant tumour growth delay, ranging from 12 to 34 days in the three neuroblastomas evaluated and in one out of three medulloblastomas. At a dose level above the maximum tolerated dose, busulphan induced complete and partial tumour regressions. Busulphan was inactive in a peripheral primitive neuroectodermal tumour (PNET) xenograft. When busulphan pharmacokinetics in mice and humans were considered, the estimated systemic exposure at the therapeutically active dose in mice (113 microg h ml(-1)) was close to the mean total systemic exposure in children receiving high-dose busulphan (102.4 microg h ml(-1)). In conclusion, busulphan displayed a significant anti-tumour activity in neuroblastoma and medulloblastoma xenografts at plasma drug concentrations which can be achieved clinically in children receiving high-dose busulphan-containing regimens.  (+info)

Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG). (4/3985)

meta-iodobenzylguanidine (MIBG) radiolabelled with iodine-131 is used for diagnosis and treatment of neuroadrenergic neoplasms such as phaeochromocytoma and neuroblastoma. In addition, non-radiolabelled MIBG, administered i.v., is used in several clinical studies. These include palliation of the carcinoid syndrome, in which MIBG proved to be effective in 60% of the patients. Oral MIBG administration might be convenient to maintain palliation and possibly improve the percentage of responders. We have, therefore, investigated the feasibility of oral administration of MIBG in an animal model. Orally administered MIBG demonstrated a bioavailability of 59%, with a maximal tolerated dose of 60 mg kg(-1). The first and only toxicity encountered was a decrease in renal function, measured by a reduced clearance of [51Cr]EDTA and accompanied by histological tubular damage. Repeated MIBG administration of 40 mg kg(-1) for 5 sequential days or of 20 mg kg(-1) for two courses of 5 sequential days with a 2-day interval did not affect renal clearance and was not accompanied by histological abnormalities in kidney, stomach, intestines, liver, heart, lungs, thymus, salivary glands and testes. Because of a sufficient bioavailability in absence of gastrointestinal toxicity, MIBG is considered suitable for further clinical investigation of repeated oral administration in patients.  (+info)

A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. (5/3985)

2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is high (70-100%), nolatrexed was administered orally, 6 hourly for 10 days, at 3-week intervals, and dose escalated from 80 to 572 mg m(-2) day(-1) in 23 patients. Common toxicity criteria (CTC) grade 3 toxicities included nausea, vomiting, stomatitis and liver function test (LFT) abnormalities. Thrombocytopenia (grade 1 or 2) occurred at doses > or = 318 mg m(-2) day(-1) and neutropenia (grade 2) at 429 and 572 mg m(-2) day(-1). An erythematous maculopapular rash occurred at dosages > or = 318 mg m(-2) day(-1) (7 out of 19 patients). LFT abnormalities occurred in two out of six patients (grade 3 or 4 bilirubin and grade 3 alanine transaminase) at 572 mg m(-2) day(-1). Nolatrexed plasma concentrations 1 h after dosing were 6-16 microg ml(-1), and trough 3-8 microg ml(-1), at 572 mg m(-2) day(-1). Inhibition of thymidylate synthase was demonstrated by elevation of plasma deoxyuridine. Six-hourly oral nolatrexed for 10 days was associated with antiproliferative effects, but nausea and vomiting was dose limiting at 572 mg m(-2) day(-1). Nine patients were treated at 429 mg m(-2) day(-1); three out of nine experienced grade 3 nausea, but 17 out of 22 treatment courses were completed (with the co-administration of prophylactic antiemetics) and this dose level could be considered for phase II testing.  (+info)

Pharmacokinetics of recombinant human granulocyte colony-stimulating factor in rabbits and mice. (6/3985)

AIM: To study the pharmacokinetics of recombinant human granulocyte colony-stimulating factor (rhGCSF) in rabbits and mice. METHODS: 125I-rhGCSF was prepared by iodogen method and determined by size exclusive HPLC (SEHPLC). RESULTS: Concentration-time curves after i.v. 125I-rhGCSF in rabbits were best fitted with 2-compartment open model. The alpha and terminal elimination T1/2 were 0.25-0.33 and 3.2-4.6 h, respectively. AUC increased with doses, and Cls and K10 were similar. Tpeak was 0.59 +/- 0.25 h after s.c., and elimination T1/2 was similar to that after i.v. The bioavailability after sc was 1.0. In mice the highest level was found in renal system, the next was bile-enteric system. Levels in lymph nodes, bone marrow, and spleen were approximately equal to or slightly lower than that in plasma, while the levels in brain, fat, and muscles were the lowest. About 68%-86% were recovered in urine and feces. CONCLUSION: Pharamcokinetics of 125I-rhGCSF in rabbits and mice provided a useful index for clinical trial.  (+info)

Pharmacokinetics of bendazac lysine in 10 Chinese young men. (7/3985)

AIM: To compare the pharmacokinetics of domestic and imported tablets of bendazao lysine (BL). METHODS: A single oral dose of 500 mg BL of this 2 kinds of tablets was given to 10 Chinese volunteers of Han nationality in a randomized crossover study. Plasma levels were determined with HPLC-UV method. Data were analyzed automatically by using a CAPP program on microcomputer. RESULTS: The plasma concentration-time curve was fitted to 2-compartment open model, and the major pharmacokinetic parameters of domestic and imported BL tablets were shown respectively as following: Cmax 66 +/- 16 and 65 +/- 8 mg.L-1; Tmax 0.98 +/- 0.22 and 0.98 +/- 0.21 h; T1/2 beta 6.2 +/- 1.8 and 6.2 +/- 1.7 h; AUC 335 +/- 47 and 337 +/- 58 mg.h.L-1. There was no significant difference between domestic and imported tablets. The bioavailability of the domestic vs that of the imported tablet was 99 +/- 12%. The unchanged BL in urine were about 5.4% and 5.6% respectively of the dosage in 24 h after a single oral dose. CONCLUSION: The two kinds of tablets had the same biological effects.  (+info)

A study of the relative bioavailability of cysteamine hydrochloride, cysteamine bitartrate and phosphocysteamine in healthy adult male volunteers. (8/3985)

AIMS: Cysteamine, the only drug available for the treatment of cystinosis in paediatric patients, is available as the hydrochloride, the bitartrate and as sodium phosphocysteamine salts. It has been suggested that cysteamine bitartrate and phosphocysteamine are better tolerated and may have a better bioavailability than cysteamine hydrochloride. This has, however, never been demonstrated. METHODS: We compared the pharmacokinetics and tolerance of these three formulations of cysteamine in 18 healthy adult male volunteers in a double-blind, latin-square, three-period, single oral dose cross-over relative bioavailability study. RESULTS: No statistical difference was found between relative bioavailabilities, AUC (0, infinity) (geometric mean and s.d. in micromol l(-1) h: 169+/-51, 158+/-46, 173+/-49 with cysteamine hydrochloride, phosphocysteamine and cysteamine bitartrate respectively), Cmax (geometric mean and s.d. in micromol l(-1); 66+/-25.5, 59+/-12, 63+/-20) and tmax (median and range in h: 0.88 (0.25-2), 1.25 (0.25-2), 0.88 (0.25-2)) with each of the three forms of cysteamine tested. Bioequivalence statistics (90% confidence intervals) showed non equivalence of Cmax of cysteamine base as the only non equivalence of pharmacokinetics between the three formulations: 90% CI for Cmax relative ratios to cysteamine hydrochloride were [75.6-105.81 for phosphocysteamine and [74.2-124.2] for cysteamine bitartrate. The only significant adverse event was vomiting whose frequency was inversely correlated with body weight (Spearman's r=-0.76, P<0.001). The nature of the salt tested did not influence vomiting. CONCLUSIONS: While none of the three forms of cysteamine tested has a clear advantage over the others in terms of pharmacokinetics and tolerance profile, this should now however be addressed in patients treated for cystinosis during repeat administrations.  (+info)

The effect of stage of maturity on the biological availability of magnesuim from wheat and orchardgrass fed to sheepThe effect of stage of maturity on the biological availability of magnesuim from wheat and orchardgrass fed to sheep
Wheat, a tetany prone forage, and orchardgrass, a non-tetany prone forage, were cut at three stages of maturity to determine the magnesium availability in these forages for lambs. The forages were dried in forced air ovens and ground through a 2.5 cm screen. The nitrogen contents of the forages were not significantly different between forages but decreased quadratically with maturity in wheat (P < .Ol) and linearly in orchardgrass (P < .Ol). Nonprotein nitrogen was significantly higher in wheat than in orchardgrass. The magnesium content of the wheat was lower (P < .O1) than orchardgrass (.14 vs .21%). Magnesium content in wheat was similar at all maturities but decreased with maturity in orchardgrass. Potassium, calcium and phosphorous levels in the forages were similar between wheat and orchardgrass but decreased with advancing maturity in both forages.. In two metabolism trials with 18 wether lambs, the biological availability of magnesium was determined for the two forages cut at three ...
Organic salts: contribution of minerals with high bioavailability and solubility - QuimidrogaOrganic salts: contribution of minerals with high bioavailability and solubility - Quimidroga
In the dietary and beverage industry, and food in general, the supply of minerals is usually made through inorganic salts. However, these salts are inefficient as they are poorly absorbed (bioavailability).. As a result, the industry has been moving for some time towards other alternatives to solve this problem: organic salts.. For this reason, in Quimidroga we incorporated in its moment a wide range of organic salts as a contribution of minerals for feeding by Jungbunzlauer. These are salts obtained by fermentation with greater bioavailability than their corresponding inorganic salts. For example, calcium citrate absorbs between 22% and 27% more than calcium carbonate.. Now, given the growing demand for mineral beverages and responding to their needs, Jungbuzlauer has expanded its range of organic salts with the launch of magnesium lactate and zinc lactate, which in addition to good bioavailability, offers greater solubility compared to other organic salts.. An added advantage of these organic ...
Bioavailability - WikipediaBioavailability - Wikipedia
Therefore, a drug given by the intravenous route will have an absolute bioavailability of 100% (f = 1), whereas drugs given by other routes usually have an absolute bioavailability of less than one. If we compare the two different dosage forms having same active ingredients and compare the two drug bioavailability is called comparative bioavailability.. Although knowing the true extent of systemic absorption (referred to as absolute bioavailability) is clearly useful, in practice it is not determined as frequently as one may think. The reason for this is that its assessment requires an intravenous reference, that is, a route of administration that guarantees that all of the administered drug reaches the systemic circulation. Such studies come at considerable cost, not least of which is the necessity to conduct preclinical toxicity tests to ensure adequate safety, as well as there being potential problems due to solubility limitations. These limitations may be overcome, however, by administering ...
A Pivotal, Phase 1, Open-Label, Randomized, Crossover, Single-Dose, Comparative Bioavailability Study of Buprenorphine-Naloxone...A Pivotal, Phase 1, Open-Label, Randomized, Crossover, Single-Dose, Comparative Bioavailability Study of Buprenorphine-Naloxone...
The primary objective of this study is to compare the bioavailability of a test formulation of Buprenorphine Naloxone Sublingual (SL) spray to that of a single
A Comparative Bioavailability Study to Compare the Pharmacokinetic (PK)and Pharmacodynamic (PD) Effects of Fluticasone...A Comparative Bioavailability Study to Compare the Pharmacokinetic (PK)and Pharmacodynamic (PD) Effects of Fluticasone...
This trial will investigate the pharmacokinetics and pharmacodynamics effects of salmeterol/fluticasone propionate [Seretide; GlaxoSmithKline] delivered by
Comparative Bioavailability Study of Lisinopril Tablets, 10 mg - Full Text View - ClinicalTrials.govComparative Bioavailability Study of Lisinopril Tablets, 10 mg - Full Text View - ClinicalTrials.gov
At screening and check-in for each period, subjects must have blood pressure and pulse rate within the following ranges: Systolic blood pressure (110-150 mmHg); Diastolic blood pressure (70-95 mmHg); Pulse (50-105 bpm). Minor deviations (1-3 mmHg) at check-in may be acceptable at the discretion of the physician investigator. For all except the first period check-in, if a subjects vital signs measurements fall outside the range specified above, the subject may, at the discretion of the physician investigator, be allowed to remain enrolled until 0-hour measurements are made. If the 0-hour protocol vital signs requirements are met, the investigator may allow dosing and the subjects continuation in the study. If 0-hour vital signs requirements are not met, the subject will not be dosed and must be withdrawn from the study. The blood pressure and pulse will be measured after the subject has been seated at least three minutes. Subjects with blood pressure and pulse measurements outside the ranges ...
Comparative Bioavailability Study of Codeine Sulfate - Full Text View - ClinicalTrials.govComparative Bioavailability Study of Codeine Sulfate - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
The most complete multinutrient formulation for men of all ages. Contains a broad spectrum of food based, highly bioavailable...The most complete multinutrient formulation for men of all ages. Contains a broad spectrum of food based, highly bioavailable...
The most complete multinutrient formulation for men of all ages. Contains a broad spectrum of food based, highly bioavailable nutrients.
WikiGenes - Biological AvailabilityWikiGenes - Biological Availability
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
El estigma del Dr. VaPorEso: Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability -...El estigma del Dr. VaPorEso: Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability -...
Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process ...
Molecules | Free Full-Text | Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is...Molecules | Free Full-Text | Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is...
Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases. The poor bioavailability of resveratrol in humans has been a major concern for translating basic science findings into clinical utility. Although a number of positive findings have emerged from human clinical trials, there remain many conflicting results, which may partially be attributed to the dosing protocols used. A number of theoretical solutions have been developed to improve the bioavailability of resveratrol, including consumption with various foods, micronized powders, combining it with additional phytochemicals, controlled release devices, and nanotechnological formulations. While laboratory models indicate these approaches all have potential to improve bioavailability of resveratrol and optimize its clinical utility, there is surprisingly very little data regarding the bioavailability of resveratrol in humans. If bioavailability is indeed a
Magnesium (glycinate) - FarmacopiaMagnesium (glycinate) - Farmacopia
Highly bioavailable magnesium chelate for sensitive individuals.* Highly bioavailable magnesium chelate* Supports metabolism of carbohydrates, amino acids and fats* Made with hypoallergenic, vegan ingredients Magnesium (glycinate) is a highly bioavailable magnesium chelate, which supports the metabolism and utilization
News | LonzaNews | Lonza
Quote from Gordon Bates, President, Chemical Division, Lonza Pharma & Biotech:. "Chemistry is core to Lonza, and we continue to innovate and invest in flexible small molecule services and site network infrastructure that benefit our customers. We are pleased to launch SimpliFiH Solutions, which integrates our core capabilities and expertise in bioavailability enhancement and drug substance development, and accelerates the first-in-human pathway for candidate molecules.". Quote from Dr. Christian Dowdeswell, VP and Head of Dosage Forms & Delivery Systems, Lonza Pharma & Biotech:. "The majority of preclinical candidate molecules require bioavailability enhancement, many even for early phase studies. We have designed SimpliFiH Services to meet the needs of customers for flexible, truly integrated packages that address the bioavailability challenge in a time- and cost-efficient manner.". Basel, Switzerland, 30 April 2019 - Lonza Pharma & Biotech announced the launch of SimpliFiHTM Services, ...
Nutrition | everpupNutrition | everpup
Checkout some of the amazing ingredients that every jar of EverPup® contains to make it the ultimate dog supplement for dogs of all ages. With no muss and no fuss, EverPup may be able to replace several other individual supplements you may now be giving. Especially since EverPup is formulated for high bioavailability, using our technology Biovadex™! Because EverPup is formulated with Biovadex, the ingredients in EverPup are highly bioavailable which means they can perform optimally.. ...
Bioavailability Enhancement Webinar Series - Nanoparticle Dispersions & Drug Nanocrystals | CapsugelBioavailability Enhancement Webinar Series - Nanoparticle Dispersions & Drug Nanocrystals | Capsugel
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Polymer mobilization and drug release during tablet swelling : A 1H NMR and NMR microimaging studyPolymer mobilization and drug release during tablet swelling : A 1H NMR and NMR microimaging study
The number of poorly water-soluble drug substances in the pharmaceutical pipeline is increasing, and thereby also the need to design effective drug delivery systems providing high bioavailability. One favourable formulation approach is preparation of solid dispersions, where dispersing a poorly water-soluble drug in a water-soluble polymer matrix improves the dissolution behaviour and the bioavailability of the drug. However, in order to take full advantage of such formulations the impact of material properties on their performance needs to be investigated.. An experimental toolbox has been designed, and applied, for analysing the processes which govern the behaviour of solid pharmaceutical formulations in general, and that of solid dispersions in particular. For the purpose of monitoring multifaceted phenomena in situ during tablet dissolution, nuclear magnetic resonance (NMR) spectroscopy and NMR imaging are superior to many other techniques, both on macroscopic and molecular levels. The ...
The Concept of Bioavailability - Amino Acids - Barnard Health CareThe Concept of Bioavailability - Amino Acids - Barnard Health Care
The bioavailability of an AA refers to the proportion of that AA that is in a form that can be digested, absorbed, and used for metabolic functions.1-1-1 Bioavailability coefficients of AAs in feedstuffs are determined in slope ratio growth assays. These assays are laborious and time consuming and only allow determination of the bioavailability of a single AA at a time, which is costly. Consequently, there are only a limited number of ingredients and AAs for which bioavailability coefficients have been determined and such coefficients of AA are not routinely used in feed formulation.. The use of bioavailability coefficients is important for heat-processed or long-stored ingredients because of the negative impact of these treatments on the bioavailability of the AA lysine. Lysine is rendered biologically unavailable by complexing with reducing compounds in the feed.. There are considerable efforts to develop simpler methods for estimating AA bioavailability in feedstuffs. A method known as the ...
Eprosartan Mesilate and breastfeeding. Are they compatible?Eprosartan Mesilate and breastfeeding. Are they compatible?
At latest update, relevant published data on excretion into breast milk were not found. A high protein-binding capacity makes excretion into breast milk unlikely. In addition, a low oral bioavailability makes difficult the absorption towards the infants plasma from ingested milk, except in prematures or newborns who may show an increased absorption. Case report of kidney function impairment of a baby whose mother had taken Telmisartan in pregnancy. Until more data on this medication is available, safer alternative drugs are preferred, especially in premature babies or during the neonatal period. Should an ARA-II medication (Sartan type) be necessary, the associated risk may be decreased by choosing the one with a favorable pharmacokinetics (shorter half-life elimination time and lower bioavailability) like Eprosartan and Losartan
Antibiotics with enhanced oral bioavailabilityAntibiotics with enhanced oral bioavailability
Which antibiotics have good / near 100% oral bioavailability? Antibiotics with enhanced oral bioavailability allows conversion to oral therapy once a patient meets defined clinical criteria. This can result in reduced length of hospital stay, health care costs, and potential complications due to intravenous access.
Glucopro - Bioavailable glucosamine for horses - Mustcare ProGlucopro - Bioavailable glucosamine for horses - Mustcare Pro
Glucopro is a combination of Glucosamine with high bioavailability and Inulin that promotes and supports healthy joints and a good intestinal flora.
Our Applications - ISALTISOur Applications - ISALTIS
OUR FLAGSHIP ACTIVES. GIVOMAG (magnesium glycerophosphate) is a highly bioavailable magnesium chelate with no side effects on the metabolism, and is part of the 3rd generation mineral salts, called "premium". Its effectiveness is proven by clinical studies, and a study carried out with LALLEMAND has proven its synergistic effect with probiotics, thanks to the presence of phosphorus in its composition. It does not contain additives and has a very low level of heavy metals. ISALTIS owns the GIVOMAG trademark and can authorize its use under license.. GIVOMAG has its own website: www.givomag.com for more information. GIVOCAL (calcium glycerophosphate) is a highly bioavailable calcium chelate with no side effects on the metabolism, and is part of the 3rd generation mineral salts, called "premium". It is in particular the salt of choice for the most sensitive applications (example: milk for premature babies or babies suffering from serious diseases). The fact that it contains phosphorus and calcium in ...
MedleyMedley
Pregnancy is a period of increased metabolic demands, with changes in the womans physiology and the requirements of a growing fetus. Nutritional requirement in pregnancy increases for carbohydrate, vitamins and micronutrients especially for Iron, Zinc and Folic acid etc. Presenting R.B.TONE forte tablets containing ferrous ascorbate providing 100 mg of elemental iron which is integral part of many proteins and enzymes that maintain good health. Ferrous ascorbate have high bioavailability with least GI side effects. Folic acid is vital for cell division and growth while zinc is essential for many functions, including growth and neurobehavioral development, immune and sensory function. Thus combination in R.B. TONE FORTE improves fetal growth and develops immune system ensuring expected outcome of pregnancy - "no maternal complication and healthy baby ...
Buy Maclar (Clarithromycin) OnlineBuy Maclar (Clarithromycin) Online
Buy Maclar Online! Maclar is a semisynthetic macrolide antibiotic, structurally very similar to erythromycin. The absolute bioavailability of Maclar after oral administration is 50-55%, which probably underestimates its systemic activity, as it undergoes extensive first pass metabolism to its active metabolite, 14-hydroxyMaclar.
Test Boost Elite amazonSupplement Rating and ReviewsTest Boost Elite amazonSupplement Rating and Reviews
Muscle repair and protein replacement: Currently, this is the main goal sought by the Test Boost Elite consumers and was discovered through research carried out in the elderly, aiming to maintain their muscle strength and avoid accidents such as falls, so common at this age.. In this research, the researchers linked low levels of testosterone with lower muscle strength, thus indicating that it increases muscle capacity and function. Because it is a supplement of high biological value, when it is ingested by bodybuilders, it restores eventual muscle losses through the training effort, in order to reduce catabolism. The plasma biological availability of this protein also helps in gaining muscle mass.. - Decreased post workout symptoms: A survey conducted by Ball State University compared the symptoms of bodybuilders after a week of overtraining. While one group took Test Boost Elite supplement after exercise, the other group took a placebo, without either group knowing which of the two products ...
Test Boost Elite at gncSupplement Rating and ReviewsTest Boost Elite at gncSupplement Rating and Reviews
Muscle repair and protein replacement: Currently, this is the main goal sought by the Test Boost Elite consumers and was discovered through research carried out in the elderly, aiming to maintain their muscle strength and avoid accidents such as falls, so common at this age.. In this research, the researchers linked low levels of testosterone with lower muscle strength, thus indicating that it increases muscle capacity and function. Because it is a supplement of high biological value, when it is ingested by bodybuilders, it restores eventual muscle losses through the training effort, in order to reduce catabolism. The plasma biological availability of this protein also helps in gaining muscle mass.. - Decreased post workout symptoms: A survey conducted by Ball State University compared the symptoms of bodybuilders after a week of overtraining. While one group took Test Boost Elite supplement after exercise, the other group took a placebo, without either group knowing which of the two products ...
Title page for ETD etd-08062002-133454Title page for ETD etd-08062002-133454
The overall objective of this project was to investigate the role of locally derived growth factors and extracellular matrix proteins in regulating prepubertal heifer mammary development. In the first experiment, short-term treatment of heifers with GH or E increased proliferation of mammary epithelial cells. Coinciding with increased epithelial cell proliferation, IGF-I protein increased and IGFBP-3 protein decreased within mammary tissues. Thus, proliferation was associated with an apparent net increase in the biological availability of IGF-I within the mammary gland. In the second experiment, decreased mammary development and epithelial cell proliferation in response to ovariectomy coincided with decreased mammary expression of IGF-I mRNA and decreased binding of IGF-I to mammary microsomes. Taken together, these results imply an important role for locally derived IGF-I in regulating heifer mammary development. However, in contrast to our hypothesis, IGF-I mRNA did not differ between cleared ...
Plus itPlus it
There are few p.o. administered chemotherapeutics currently available with demonstrated efficacy against i.c. tumors. The principal finding in our study is that ZD1839, a p.o.-active EGFR-TKI, is efficacious against i.c. tumors expressing the wild-type EGFR. This is important not only for EGFR-expressing primary malignant tumors of the CNS but also metastatic tumors that also frequently overexpress EGFR and that commonly seek refuge within the CNS. Previous studies have shown that oral administration of ZD1839 to rats (5 mg/kg) yields a terminal half-life of approximately 3-13.8 h in male animals and 5-8.2 h in female animals (data on file at AstraZeneca). The absolute bioavailability after oral dosing at 5 mg/kg was 49.8%. Consequently, when dosage was increased to 12.5 mg/kg, the absolute bioavailability was 76.7 and 87.6% in male and female animals, respectively. On the basis of this information, we had reason to believe that in our experiments treating with nontoxic doses 10-20-fold higher ...
Vitae CalVita® 60 Tablets - i-Health UAEVitae CalVita® 60 Tablets - i-Health UAE
Description CalVita® is a combination based on calcium salts, phosphorus, vitamin D3 and bamboo dry extract, which has a high-efficiency thanks to its high bioavailability. This supplement is formulated to help improve bone health naturally. Instructions Take 2 to 4 tablets a day with food and a large glass of water, s
Peptides Archives - Nootro HackerPeptides Archives - Nootro Hacker
Ok so, Noopept has been proven to cause minimal negative effects when used based on recommended doses and has a really low toxicity levels.. A lot users who know anything about other Racetams, like Piracetam and Oxiracetam for example, are probably going to know that these types of nootropics have headache as a common side effect.. Noopept, on the other hand, can reduce headaches or not cause them at all.. Its able to avoid headaches because Noopept works to affect Glutamate and not Acetylcholine neurotransmitters that are going to use up your brains supply of choline.. Also, Noopept doesnt lead to digestive problems when it is being used at the ideal dosage.. Because of its really high bioavailability level almost all of it is going to get soaked up down in the GI tract and before it goes toward the brain so you probably wont have any problems.. With that being said there have been cases of where people who take abnormally large doses of Noopept do experience upset stomach and GI tract ...
Nootropics Archives - Nootro HackerNootropics Archives - Nootro Hacker
Ok so, Noopept has been proven to cause minimal negative effects when used based on recommended doses and has a really low toxicity levels.. A lot users who know anything about other Racetams, like Piracetam and Oxiracetam for example, are probably going to know that these types of nootropics have headache as a common side effect.. Noopept, on the other hand, can reduce headaches or not cause them at all.. Its able to avoid headaches because Noopept works to affect Glutamate and not Acetylcholine neurotransmitters that are going to use up your brains supply of choline.. Also, Noopept doesnt lead to digestive problems when it is being used at the ideal dosage.. Because of its really high bioavailability level almost all of it is going to get soaked up down in the GI tract and before it goes toward the brain so you probably wont have any problems.. With that being said there have been cases of where people who take abnormally large doses of Noopept do experience upset stomach and GI tract ...
Plant Protein - Norti ChocolatePlant Protein - Norti Chocolate
Raw Hemp Protein High Bioavailability (absorption into body) No psychotropic reaction - they are safe and healthy to eat Raw, Cold-processed Contains a Complete Amino Acid Profile Including the 9 Essential Amino Acids Ideal 3:1 Omega-3 vs. Omega-6 fatty acids Rich in GLAs (Gamma-Linoleic Acids) The hemp seeds, from wh
Digestion - Health ConcernsDigestion - Health Concerns
Dairy-free, great-tasting vegetarian protein powder with non-GMO pea yellow peas. High bioavailability and digestibility and a wide array of amino acids, very similar to whey. Supports healthy cholesterol and blood [...] ...
Nutrition‎ Archives - Page 7 of 7 - All about medicineNutrition‎ Archives - Page 7 of 7 - All about medicine
You should seize only do a weakly buffered Kerasal like Salicylic acid and urea topical. Salicylic acid and although urea topical is uniquely formulated with our bema drug delivery technology that allows approximately for assessing high bioavailability of Salvax duo in the bloodstream, and beliefs represents an important new option for patients and healthcare providers. Read More. ...
Determination of the Absolute Bioavailability of GSK2118436 Following a Single Oral Dose Co-Administered With an Intravenous...Determination of the Absolute Bioavailability of GSK2118436 Following a Single Oral Dose Co-Administered With an Intravenous...
GSK2118436 is an orally administered, potent and selective small molecule BRAF inhibitor that is currently being developed for the treatment of BRAF mut
Fascination About ketamine clinic start upFascination About ketamine clinic start up
Dr. David Hough, the crew chief on Janssens esketamine job, absolutely thinks so. He touts esketamines "high bioavailability"- which means that far more on the drug will make its way to the brain-and many stellar quantities: a sixty to 70 p.c response charge and 6 to 8 months of http://trainer-albuquerque60371.blogolize.com/The-2-Minute-Rule-for-start-a-ketamine-clinic-9793483 ...
Overcome Major Barriers To The Oral Delivery Of MacromoleculesOvercome Major Barriers To The Oral Delivery Of Macromolecules
Due to their poor oral bioavailability, oligosaccharides are formulated as solutions or suspensions and delivered by invasive intravenous (IV) or...
Pfizer Medische Informatie - Netherlands (Nederland)Pfizer Medische Informatie - Netherlands (Nederland)
Absorption - Oral absorption appears to be dose dependent. Peak plasma concentrations are reached within 0.75 to 6.0 hours following oral administration. At doses of 30 mg/m2 or less, methotrexate is generally well absorbed with a mean bioavailability of about 60%. The absorption of doses greater than 80 mg/m2 is significantly less, possibly due to a saturation effect.. In leukemic pediatric patients, oral absorption of methotrexate also appears to be dose dependent and has been reported to vary widely (23% to 95%). A twenty fold difference between highest and lowest peak levels (Cmax: 0.11 to 2.3 micromolar after a 20 mg/m2 dose) has been reported. Significant interindividual variability has also been noted in time to peak concentration (Tmax: 0.67 to 4 hrs after a 15 mg/m2 dose) and fraction of dose absorbed. The absorption of doses greater than 40 mg/m2 has been reported to be significantly less than that of lower doses. Food has been shown to delay absorption and reduce peak concentration. ...
microsoft word - k34b.spc.doc)microsoft word - k34b.spc.doc)
duration of action (inhibition of acid secretion). Biotransformation: Pantoprazoles serum protein binding is about 98%. The substance is almost exclusively metabolized in the liver. Renal elimination represents the major route of excretion (about 80%) for the metabolites of pantoprazole, the rest are excreted with the faeces. The main metabolite in both the serum and urine is desmethylpantoprazole which is conjugated with sulphate. The half-life of the main metabolite (about 1.5 h) is not much longer than that of pantoprazole. Bioavailability: Pantoprazole is completely absorbed after oral administration. The absolute bioavailability from the tablet was found to be about 77%. Concomitant intake of food had no influence on AUC, maximum serum concentration and thus bioavailability. Only the variability of the lag-time will be increased by concomitant food intake. Linearity: Pharmacokinetics do not vary after single or repeated administration. In the dose range of 10 to 80 mg, the plasma kinetics ...
Biomarker Development | PharmOptima LLCBiomarker Development | PharmOptima LLC
Your compounds can be tested in PharmOptimas 6500 square foot vivarium for in vivo bioavailability, metabolism, pharmacologic efficacy, and tolerance.
präsystemische Metabolisierung | first-pass effect/presystemic metabolizationpräsystemische Metabolisierung | first-pass effect/presystemic metabolization
(KudoZ) German to English translation of präsystemische Metabolisierung: first-pass effect/presystemic metabolization [Medical: Pharmaceuticals (Medical)].
CBD Bioavailability and First-Pass Effect - Canna-Pet®CBD Bioavailability and First-Pass Effect - Canna-Pet®
CBD Bioavailability and First-Pass Effect. First-Pass Metabolism Also known as the hepatic first pass effect - any product absorbed from the gastrointestinal tract is first delivered to the liver
Clinical trial: Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations...Clinical trial: Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations...
Clinical trial: Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations of Extended Release Metformin and Extended Release Glimepiride in Health Volunteers
Comparative Bioavailability of Two Oral Oseltamivir Formulations: Commercial Capsules and an Emergency Solution Prepared...Comparative Bioavailability of Two Oral Oseltamivir Formulations: Commercial Capsules and an Emergency Solution Prepared...
Comparative Bioavailability of Two Oral Oseltamivir Formulations: Commercial Capsules and an Emergency Solution Prepared During the 2009 Influenza a (H1n1) Outbreak in Mexico Abstract.
Quorns Mycoprotein bioavailability equivalent to animal proteinQuorn's Mycoprotein bioavailability 'equivalent' to animal protein
Bioavailability refers to how easy it is for the body to digest, absorb and use a protein in its metabolic processes. Some foods have a greater bioavailability than others. Animal proteins like milk are known to have high bioavailability, meaning that they support muscle building.. Researchers from the University of Exeter compared milk protein with Mycoprotein - the patent-protected protein used in Quorn products - and found "equivalent"​ bioavailability.. Detailing the study, which was published in British Journal of Nutrition​, the researchers said that they investigated the impact of mycoprotein ingestion, in a dose-response manner, on acute postprandial hyperaminoacidaemia and hyperinsulinaemia.. In all, 12 healthy young men completed five experimental trials in a randomised, single-blind, cross-over design. During each trial, volunteers consumed a test drink containing either 20 g milk protein, mass matched (not protein matched due to the fibre content) mycoprotein, or a protein ...
High Bioavailability Curcumin Supplements from Indena, Dolcas Biotech, Verdure Sciences, and Theravalues | EmediaHealthHigh Bioavailability Curcumin Supplements from Indena, Dolcas Biotech, Verdure Sciences, and Theravalues | EmediaHealth
There are some good choices today for curcumin supplements designed to improve bioavailability, much better than the options that existed even just five years ago. But even with these choices, if you are aiming to maintain significant levels of curcumin in your blood at all times for maximum effect, you are going to need to take two or three doses per day spaced evenly.. Ive not noted any particular digestive upset from taking curcumin with other supplements without a big meal, but this varies from person to person and also depends upon the other supplements you are taking. If you find that you need to take it with some food to minimize digestive upset, Id suggest you try taking one dose in the morning with breakfast and another shortly before bedtime with a small protein-rich snack with some fat content such as cottage cheese. If you choose to take a third dose each day, take it with an afternoon snack or an early dinner.. Consider taking curcumin along with other beneficial oils and fats to ...
endocrinology - why a testosterone pill cant be effective? - Biology Stack Exchangeendocrinology - why a testosterone pill can't be effective? - Biology Stack Exchange
As stated in the comments by Eliane B., testosterone can actually be administered orally when an undecanoate ester is attached. The reason regular testosterone cannot be adminstered orally is because it undergoes extensive first pass metabolism (oxidation of the 17b-hydroxyl group to a 17-keto group, catalyzed by 17b-hydroxysteroid dehydrogenase enzymes, which are active in the liver). The undecanoate ester makes the substance lipophilic enough to be transported by the lymphatic system to the circulation after absorption by the intestines. Without the ester it will first reach the liver via the portal vein, thus exposing it to first pass metabolism. Nevertheless, bioavailability of oral testosterone undecanoate is estimated to be less than 10% [1].. Besides that, there are also derivates of testosterone which have a high oral bioavailability. These derivates have an alpha-oriented alkyl group, usually methyl, at position C-17, which retards hepatic metabolism. However, this can lead to ...
Frontiers | A Relative Bioavailability Study of Two Misoprostol Formulations Following a Single Oral or Sublingual...Frontiers | A Relative Bioavailability Study of Two Misoprostol Formulations Following a Single Oral or Sublingual...
IntroductionMisoprostol (Cytotec) was primarily made for treating gastric ulcers. However today it is mostly used for abortion, treating postpartum hemorrhage, and for induction of labor. The tablet contains 200 µg of misoprostol, yet the dosages used for induction of labor are much smaller (25-50 µg), leading to uncertainty of dosage in daily use.AimTo evaluate and compare the relative bioavailability of two misoprostol products (Angusta 25 µg and Cytotec 200 µg tablets) administered orally or sublingually given in a daily clinical setting to women admitted for induction of labor at term.MethodsWomen carrying a live, singleton fetus in a cephalic position and with a gestational age between 259 and 296 days were included. Blood samples were collected at 0, 5, 10, 20, 30, 40, 50, 75, 100, 120, 180, and 240 minutes. A serum analytical assay was performed and pharmacokinetic parameters were calculated. Patients were assigned to one of three groups.ResultsA total of 72 patients were included. No
In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. | Sigma-AldrichIn vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Stavroula Stoupi, Gary Williamson, Florian Viton, Denis Barron, Laurence J King, Jonathan E Brown, Michael N Clifford].
Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice | Journal of...Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice | Journal of...
The current study indicates that administration of the dual ABCB1 and ABCG2 inhibitor tariquidar results in a statistically significantly increase in plasma, liver and brain exposure to imatinib. Since imatinib is known to have very high bioavailability (approximately 98%) [1], it is likely that the difference in plasma AUC is due to modified distribution and/or elimination of the drug, rather than a change in the extent of intestinal absorption. This hypothesis is supported by the fact that tariquidar increased the peak plasma concentration of imatinib by less than 20% and this change was not statistically significant. As expected, there was also no apparent change in the rate of absorption. Considering that imatinib is effluxed by both ABCB1 and ABCG2, the almost complete bioavailability may seem somewhat surprising. However, it is possible that the high concentrations of imatinib in the gut are actually leading to localized inhibition of these transporters, as has been suggested by inhibition ...
These highlights do not include all the information needed to use PRAVASTATIN SODIUM TABLETS safely and effectively. See full...These highlights do not include all the information needed to use PRAVASTATIN SODIUM TABLETS safely and effectively. See full...
General Absorption Pravastatin sodium is administered orally in the active form. In studies in man, peak plasma pravastatin concentrations occurred 1 to 1.5 hours upon oral administration. Based on urinary recovery of total radiolabeled drug, the average oral absorption of pravastatin is 34% and absolute bioavailability is 17%. While the presence of food in the gastrointestinal tract reduces systemic bioavailability, the lipid-lowering effects of the drug are similar whether taken with or 1 hour prior to meals.. Pravastatin plasma concentrations, including area under the concentration-time curve (AUC), Cmax, and steady-state minimum (Cmin), are directly proportional to administered dose. Systemic bioavailability of pravastatin administered following a bedtime dose was decreased 60% compared to that following an AM dose. Despite this decrease in systemic bioavailability, the efficacy of pravastatin administered once daily in the evening, although not statistically significant, was marginally more ...
DailyMed - PRAVASTATIN SODIUM tabletDailyMed - PRAVASTATIN SODIUM tablet
General Absorption Pravastatin sodium is administered orally in the active form. In studies in man, peak plasma pravastatin concentrations occurred 1 to 1.5 hours upon oral administration. Based on urinary recovery of total radiolabeled drug, the average oral absorption of pravastatin is 34% and absolute bioavailability is 17%. While the presence of food in the gastrointestinal tract reduces systemic bioavailability, the lipid-lowering effects of the drug are similar whether taken with or 1 hour prior to meals.. Pravastatin plasma concentrations, including area under the concentration-time curve (AUC), Cmax, and steady-state minimum (Cmin), are directly proportional to administered dose. Systemic bioavailability of pravastatin administered following a bedtime dose was decreased 60% compared to that following an AM dose. Despite this decrease in systemic bioavailability, the efficacy of pravastatin administered once daily in the evening, although not statistically significant, was marginally more ...
Lisinopril first pass metabolism - Metformin bivirkninger diarreLisinopril first pass metabolism - Metformin bivirkninger diarre
meilleur sites de piratage. http://testadsl.menara.ma/speed.php http://www.ratiatum.com/: pir to. such as children who pass to Hutchison Rudimentary School.Lisinopril hctz makes me tired Lisinopril make me tired Lisinopril. you`ll have to deal with it and wait for these phase to pass. Why dows lisinopril make.Long-term renoprotective effect of nisoldipine and lisinopril in type 1 diabetic patients with diabetic nephropathy. Diabetes Care, Dec 2000.. it was first described in medical literature. thus taking advantage of the blockade exerted by quinidine on the first-pass hepatic metabolism of.Emergency Cardiac Drugs by. • Oral nitroglycerin undergoes significant first-pass metabolism and has less than 1%. (Vasotec) • Lisinopril.. ...
First-pass hepatic uptake and utilization of glucose in the rat | Biochemical JournalFirst-pass hepatic uptake and utilization of glucose in the rat | Biochemical Journal
First-pass hepatic retention of glucose had previously been measured indirectly from the appearance of ingested labelled glucose into the systemic circulation. To determine the accuracy of the procedure, results obtained by this indirect method were compared with those of direct measurement of hepatic retention of labelled glucose given by instantaneous injection into the portal vein. In the rat, the indirect procedure gave a value of 13.7 +/- 2.3%. In the direct method, [14C]glucose was injected intraportally together with [3H]sucrose as a marker of extracellular distribution. Hepatic content of both labels was maximal immediately after administration; the content of sucrose fell to basal values by 15 s, indicating that the injected bolus had passed through the liver; the content of [14C]glucose continued to fall for 90 s. The difference in tissue retention between glucose and sucrose, representing intracellular glucose, was constant from 90 to 180 s, and indicated a first-pass retention of 13 ...
Assessment of iron bioavailability and protein quality of new fortified blended foods in broiler chickensAssessment of iron bioavailability and protein quality of new fortified blended foods in broiler chickens
Fortified-blended foods (FBFs), grain-legume porridges (most commonly corn and soy), are frequently used for food aid purposes. Sorghum and cowpea have been suggested as alternative FBF commodities because they are drought-tolerant, grown locally in food aid receiving countries, and are not genetically modified. The objective of this thesis was to determine the protein quality and iron bioavailability of newly formulated, extruded FBFs in broiler chickens, which have been suggested as a good model for assessing iron bioavailability. Five FBFs were formulated to contain whey or soy protein to compare protein quality, sugar, oil, and an improved micronutrient premix. These included three white sorghum-cowpea FBFs; two were extruded with either whey protein concentrate (WSC) or soy protein isolate (WSC+SPI) added, one was non-extruded (N-WSC). Two others were white sorghum-soy (WSS) and corn-soy (CSB14) FBFs. Two additional white-sorghum cowpea FBFs were reformulated and "over-processed" to contain ...
Review details growing scientific backing for curcumin benefitsReview details growing scientific backing for curcumin benefits
Curcumin is a molecule that is notoriously difficult to absorb. There is evidence that turmeric in its basal state, when used as a persistent part of the diet, can exert health benefits, including antimicrobial effects​​, even with its poor absorption profile. The curcumin content of turmeric samples tested in India recently varied widely​​, from a low of about 2.5% to a high of almost 9% by weight. The discussion among researchers then has been what dosages in a dietary supplement application are effective, given that so little of the active ingredients actually end up crossing the blood barrier. "Despite its reported benefits via inflammatory and antioxidant mechanisms, one of the​ major problems with ingesting curcumin by itself is its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. Several agents have been tested to improve curcumins bioavailability by addressing these various mechanisms," ​Drs Kalman and ...
Bioavailability - WikipediaBioavailability - Wikipedia
Therefore, a drug given by the intravenous route will have an absolute bioavailability of 100% (f = 1), whereas drugs given by other routes usually have an absolute bioavailability of less than one. If we compare the two different dosage forms having same active ingredients and compare the two drug bioavailability is called comparative bioavailability.[citation needed] Although knowing the true extent of systemic absorption (referred to as absolute bioavailability) is clearly useful, in practice it is not determined as frequently as one may think. The reason for this is that its assessment requires an intravenous reference; that is, a route of administration that guarantees all of the administered drug reaches systemic circulation. Such studies come at considerable cost, not least of which is the necessity to conduct preclinical toxicity tests to ensure adequate safety, as well as potential problems due to solubility limitations. These limitations may be overcome, however, by administering a ...
Abstract 17875: Endothelial Cell Insulin Sensitivity and Nitric Oxide Bioavailability Are Regulated by Insulin-Like Growth...Abstract 17875: Endothelial Cell Insulin Sensitivity and Nitric Oxide Bioavailability Are Regulated by Insulin-Like Growth...
The growth promoting hormone Insulin-like growth factor-1 (IGF-1) similar to insulin may be an important regulator of nitric oxide (NO) bioavailability. We have previously reported in two murine models of reduced IGF-1 receptor (global hemizygous knockout (IGFRKO) and endothelial cell specific IGF-1R knockout (ECIGFRKO)) evidence of increased basal NO production in the vasculature, with augmentation of this increase relative to decreasing IGF-1R number (WT v ECIGFRKO hemizygotes p=0.01, WT vs ECIGFRKO homozygotes p = 0.001). Furthermore, by decreasing IGF-1R numbers in the insulin resistant hemizygous insulin receptor knockout (IRKO) model (IRKO x IGFRKO) insulin sensitivity in the vasculature can be restored. In this study, we have investigated further these receptor interactions with the generation of a mouse overexpressing the human IGF-1R specifically in the endothelium under control of the Tie-2 promoter-enhancer (hIGFREO) and by targeted knockdown of the IGF-1R in human endothelial cells. ...
Relapse of rheumatoid arthritis after substitution of oral for parenteral administration of methotrexate | Annals of the...Relapse of rheumatoid arthritis after substitution of oral for parenteral administration of methotrexate | Annals of the...
After oral administration MTX is rapidly but incompletely absorbed. Its bioavailability is about 70% at low doses (≤10 mg/m2), approximately 15-20% lower than that of intramuscular (IM) or intravenous (IV) MTX.4,5 In addition, there is a marked interindividual and a moderate intraindividual variability in the extent of absorption of oral MTX.6 Oral administration in doses above 25 mg/day is associated with lower bioavailability due to the saturation of the absorption mechanism. Thus in high doses the parenteral administration is mandatory.7 IM MTX showed higher bioavailability than oral MTX either as tablets or as solution.8 However, other studies have shown a similar MTX concentration after oral, IM, or IV administration.5,9. To compare the relative bioavailability of oral versus intramuscular administration in patients with RA, the pharmacokinetics of MTX at both the usual starting dose of 7.5 mg and at established higher maintenance doses was examined in 21 patients.10 Pharmacokinetics ...
Factors Affecting the Bioaccessibility and Bioavailability o... : EpidemiologyFactors Affecting the Bioaccessibility and Bioavailability o... : Epidemiology
When assessing the risks to children and adults due to contaminated soil and/or house dust, it has become clear over the past 25 years that ingestion does not equal the absorbed dose. That is, not all of the chemical in these media will be absorbed due to a myriad of chemical interactions with the different types of soil and dust present in the environment. To characterize the likely absorbed dose, many factors need to be considered. Theoretically, physiochemical characteristics should govern interactions between the contaminant and soil matrix and may affect solubilization, gastrointestinal absorption, and subsequently absolute oral bioavailability. Once solubilized and bioaccessible, a chemical must undergo absorption from the gut into systemic circulation. Absorption is most affected by chemical ionization, lipophilicity, and solubility. However, nearly 3 decades of research have not given sufficient insight to develop a universal model for predicting bioaccessibility. In this paper, we ...
Astymin Forte | Welcome to TIL HealthcareAstymin Forte | Welcome to TIL Healthcare
Forte is utilization of the Maurmerization technology, providing more complete intake of the products ingredients.. Astymin Forte represents an encapsulated combination of 7 types of granules of different colors. Dissolution rate of each granule type is carefully calculated to allow the dissolution within the prescribed time and in certain regions of gastrointestinal tract. As a result the amino acids and vitamins, which can be found in Astymin Forte, are absorbed in the blood stream slowly and as much as possible, providing 98% bioavailability! So far, such a high bioavailability is completely unattainable for other amino acid and vitamin complexes!. Distribution of active ingredients in the granules of Astymin Forte furthermore provides a very short time to maximum blood amino acid concentration after the product administration - about 20-30 minutes.. As opposed to Astymin Forte most amino acid and vitamin complexes are manufactured in traditional presentation. Due to this active substances ...
Fundamental Toxicological SciencesFundamental Toxicological Sciences
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder. Although there is no established treatment for the core symptoms of ASD, recent research has indicated a potentially therapeutic effect of intranasally administered oxytocin. TTA-121 is a novel oxytocin nasal spray with high bioavailability and is expected to increase oxytocin delivery to the brain by adjusting osmolality and viscosity of the formulation. As nonclinical safety studies to support the conduct of the Phase 1 and Phase 2 studies of TTA-121, a 6-week repeated intranasal dose toxicity study of TTA-121 in rats was conducted. In the present study, TTA-121 was administered intranasally to male and female rats at 0 (placebo), 1.2, 6, and 30 U/body/day once daily for 6 weeks followed by a 4-week recovery period to evaluate potential toxicity and systemic exposure to oxytocin. The toxicokinetic analysis indicated that systemic exposure of oxytocin increased with a dose ranging from 1.2 to 30 U/body/day at the ...
Magnesium (glycinate) 120 mg - 180 Vegetarian Capsule by Pure EncapsulationsMagnesium (glycinate) 120 mg - 180 Vegetarian Capsule by Pure Encapsulations
Magnesium (glycinate) Magnesium (glycinate) is a highly bioavailable magnesium chelate, which supports the metabolism and utilization of carbohydrates, amino acids and fats for energy. Magnesium (glycinate) helps activate enzymes for physiological functions including cardiac health. Highly bioavailable magnesium chelat
Efficacy of highly bioavailable zinc from fortified water: a randomized controlled trial in rural Beninese children. | Sigma...Efficacy of highly bioavailable zinc from fortified water: a randomized controlled trial in rural Beninese children. | Sigma...
Sigma-Aldrich offers abstracts and full-text articles by [Valeria Galetti, Prosper Kujinga, Comlan Evariste S Mitchikpè, Christophe Zeder, Fabian Tay, Félicien Tossou, Joseph D Hounhouigan, Michael B Zimmermann, Diego Moretti].
ArtikkelitArtikkelit
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases ...
Geoscience Research Institute | Stability of Organic Molecules: Lessons from Vitamin CGeoscience Research Institute | Stability of Organic Molecules: Lessons from Vitamin C
Vitamin stability has been studied for decades under a variety of storage conditions, and it is interesting to see how chemical manufacturers address long term stability issues. As stated on the website of DSM (a chemical company located in the Netherlands): "The vitamin manufacturing industry has developed products of high purity and quality, with improved stability, high bioavailability and optimum handling and mixing properties…. However, when dealing with complex and reactive compounds such as the vitamins, no product form can offer complete and unlimited protection against destructive conditions, excessive periods of storage or severe manufacturing processes. The individual feed manufacturer must take responsibility for assuring customers that vitamins have been stored, handled and added to feeds in an optimum manner and that vitamin levels are routinely monitored for quality assurance.". Temperature, water content, pH, oxygen levels, light (type/intensity), catalysts (metals like Fe, Cu, ...
Organic PurePeaâ„¢ Chocolate - Protein/Amino Acid Formulas - Foundational - Product Category | Professional Choice VitaminsOrganic PurePeaâ„¢ Chocolate - Protein/Amino Acid Formulas - Foundational - Product Category | Professional Choice Vitamins
Organic PurePeaâ„¢, an organic, natural pea protein isolate, offers a high level of functionality and nutritional benefits. Organic PurePeaâ„¢ is a true vegan protein which has high bioavailability and excellent digestibility.* The raw materials, certified or
Selenium enriched yeast for animal feed: ALKOSEL R397 | Lallemand Animal NutritionSelenium enriched yeast for animal feed: ALKOSEL R397 | Lallemand Animal Nutrition
ALKOSELR397 is a specific inactivated whole cell yeast (Saccharomyces cerevisiae NCYC R397) product containing elevated levels of organic selenium (min. 98%).. It is registered and authorized in the European Union as a nutritional feed additive for all animal species (EC 3b8.11). It contains more than 98% of selenium in an organic form (this means the element selenium is metabolized by the yeast and part of the amino acids and proteins).. Due to its high bioavailability, ALKOSELR397 optimizes the animals selenium status, which helps realize their full growth and production potential. The product quality and consistency of ALKOSELR397 guarantees animal performance, which will, in turn, result in increased profitability.. ...
Antivirals - Health TipsAntivirals - Health Tips
n humans, they are converted to acyclovir and penciclovir.This causes their close morphological and histological properties.. mechanism of action of acyclovir is in the interaction with enzymes of the virus, and then interrupted their development cycle.The result is the death of the microorganism.This interaction ensures the structure of acyclovir, which is similar to dezoksiguanedina (purine nucleoside).The most sensitive to this drug is the herpes simplex virus.There are strains of microorganisms which are resistant to this drug.This effect can be explained by the use of immunosuppressive therapy.The mechanism of resistance is a mutation of the virus enzyme systems, changing the specificity of the drug.In the event of such situations are drugs of other pharmacological groups ("Foscarnet").Children antivirals include "Valacyclovir."The high bioavailability, which is more than fifty percent causes a similar effect.This means that to achieve the effect required much smaller doses of the drug ...
Magnesium Malate PowderMagnesium Malate Powder
Magnesium malate is a combination of magnesium molecules with malic acid. Magnesium malate is well tolerated and has a very high bioavailability. The exceptionally small particle size of magnesium and the fact that it is bound to malic acid guarantees
Could Ginger be Used Medicinally? | PuraTHRIVE Liposomal ProductsCould Ginger be Used Medicinally? | PuraTHRIVE Liposomal Products
Some of the studies cited above simply used raw ginger powder to achieve the reported results, so this approach certainly has proven merit (and its nearly always the least expensive).. Simply brewing tea with ginger powder (or even mixing the powder into room temperature water) can provide relief from nausea, headaches, and other everyday maladies. Raw ginger root also adds a nice kick to smoothies and cooked dishes, so for an extra antioxidant and anti-inflammatory boost, throw some in whenever you think of it.. If you want to implement ginger as an acute therapeutic agent for the prevention and treatment of disease, though, its best to work with concentrated full-spectrum extracts and oils (especially those that have been optimally formulated for high bioavailability).. This product is our favorite, especially if youre seeking out ginger for any kind of pain relief-its a powerful complex of liposomal ginger oil, curcumin (the famed healing component in turmeric), and vegan DHA (which also ...
Butycaps - Universal BiologyButycaps - Universal Biology
BUTYCAPS 900 mg Tributyrin (787 mg Butyric Acid) / sachet BUTYCAPS is a food supplement containing Microencapsulated Tributyrin.. Tributyrin is a triglyceride containing 3 molecules of butyric acid. It is a form of administration ensuring high bioavailability of butyric acid in all sections of the intestine.. Butyric acid has important actions for intestinal health, comprising both nutrition and trophism of the intestinal cells, such as favoring a balanced intestinal microbiota.. The microencapsulation technology of BUTYCAPS allows a slower and gradual release along the intestine.. BUTYCAPS are non-chewable granules.. Each sachet contains 900 mg of tributyrin microencapsulated, equivalent to 787 mg of butyric acid. Each box contains 30 sachets.. Recommended Dosage: 1 sachet per day. Other dosages may be followed after the advice of a healthcare professional.. How to Use: Open the sachet and add its content to a yogurt or to a pureed consistency food. It can also be poured directly into the mouth ...
Pharmacokinetics and bioavailability of digitoxin by a specific assay<...Pharmacokinetics and bioavailability of digitoxin by a specific assay<...
TY - JOUR. T1 - Pharmacokinetics and bioavailability of digitoxin by a specific assay. AU - MacFarland, R. T.. AU - Marcus, F. I.. AU - Fenster, P. E.. AU - Graves, P. E.. AU - Perrier, D.. PY - 1984/1. Y1 - 1984/1. N2 - The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 days. After oral administration, the elimination half-life was 5.8 days. The bioavailability was 81.5% using the specific assay. Using a non-specific, direct serum digitoxin radioimmunoassay the bioavailability was 98.0%. Assay of aqueous fractions from extracted serum samples indicated higher levels of water-soluble metabolites following oral compared to intravenous digitoxin administration. These findings suggest that previously reported values for digitoxin ...
Gonçalves MAD, Dritz SS, Tokach MD, et al. Fact sheet - Ingredient database management for swine: phosphorus. J Swine Health...Gonçalves MAD, Dritz SS, Tokach MD, et al. Fact sheet - Ingredient database management for swine: phosphorus. J Swine Health...
Bioavailable P is the proportion of P that can be absorbed and available for use or storage.4 The most common methods to estimate P bioavailability are the slope-ratio assay and digestibility experiments. The slope-ratio assay method theoretically estimates the digestible plus post-absorptive utilization of P at the tissue level and is known as available P (AvP), whereas digestibility experiments measure only digestible utilization, known as digestible P.5. Available P. In the slope-ratio assay method, linear regression is fitted to the response criterion (eg, growth performance or bone ash) for each set of titrated diets (new versus inorganic standard ingredient) and the slope of the equation from the ingredient is divided by the slope from the inorganic standard. The drawbacks of the slope-ratio assay method1,5 are mainly assumption that the inorganic standard is 100% bioavailable, thus it is important to use the same standard for all ingredients; dependence on the response criterion used ...
QualityCounts.com Newsletter of 4/13/11QualityCounts.com Newsletter of 4/13/11
As far as the synergy, I would think that most would be already taking the CoQ-10, resveratrol, B-vitamins and green tea.. Curcumin-soy formulation may boost absorption 60-fold: Indena study - Nutra USA, 4/6/11 - Curcumin has been a sort of forbidden fruit for biomedical research, since its poor oral bioavailability has substantially hampered clinical development, despite the very promising indications of the preclinical research ... The volunteers received five (low-dose - 209 mg total curcuminoids) or nine (high-dose - 376 mg total curcuminoids) hard-shell capsules of either the soybean-based phospholipid-curcumin formulation (Meriva) or five capsules of a non-formulated curcuminoid mixture containing 1799 mg of curcuminoids ... Total curcuminoid absorption was about 29-fold higher for Meriva than for its corresponding unformulated curcuminoid mixture, but only phase-2 metabolites could be detected, and plasma concentrations were still significantly lower than those required for the ...
Recent Progress in theEstimation of Druglike Molecules by the Nonlinear Regression of Multiwavelength Spectrophotometric pH...Recent Progress in theEstimation of Druglike Molecules by the Nonlinear Regression of Multiwavelength Spectrophotometric pH...
US Department of Health and Human Service, FDA Center for Drug Evaluation and Research (CDER) Draft Guidance: Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Dosage Forms Containing Certain Active Moieties/Active Ingredients Based on a Biopharmaceutic Drug Classification System. CDERGUID-2062 DFT.WPD, January 1999. ...
Best 5 Vitamin C Supplements For Boosting Immunity - Supplement ReviewsBest 5 Vitamin C Supplements For Boosting Immunity - Supplement Reviews
But we humans have BRAIN - Scientists successfully solved this by a path-breaking discovery of LIPOSOMAL DRUG DELIVERY SYSTEM.. Here Vitamin C is successfully encapsulated in a lipid carrier-liposome before ingestion. This lipid capsule insulates our fragile vitamin from the ruthless gastric acidity and enzyme attacks. By acquiring a smaller size and lipid soluble nature, this liposomal vitamin complex can then easily diffuse through intestinal mucosal lining bypassing the need of transporters. This facilitates a miraculous increase in absorption and intensifies bioavailability.. Along with the positive effect on bioavailability, liposomal complex also reduces the gastric discomfort caused by the acidic nature of vitamin C.. ...
CysteineCysteine
CysteineCysteine
Common firecrestCommon firecrest
Hauling-outHauling-out
FolateFolate
Alkaline earth metalAlkaline earth metal
Environment, health and safetyEnvironment, health and safety
Health management systemHealth management system
Karner blueKarner blue
Stazione ZoologicaStazione Zoologica
PersonalityPersonality
Eurasian woodcockEurasian woodcock
Susan GoldenSusan Golden
CompostCompost
BacteriaBacteria
CompostCompost
AcartiaAcartia
Alkaline earth metalAlkaline earth metal
Privet as an invasive plantPrivet as an invasive plant
CysteineCysteine
FolateFolate
Ludwig von BertalanffyLudwig von Bertalanffy
Goobang National ParkGoobang National Park
Nitrogen cycleNitrogen cycle
Hemidactylus kyaboboensisHemidactylus kyaboboensis
Hemidactylus eniangiiHemidactylus eniangii
CrepidulaCrepidula
Bowens KaleBowen's Kale
NicomorphineNicomorphine
Loop diureticLoop diuretic
EatingEating
QIAGEN Silicon ValleyQIAGEN Silicon Valley
Group 3 elementGroup 3 element
Positron emission tomographyPositron emission tomography
LeafLeaf
EbolaEbola
MallardMallard
TechnologyTechnology
MedicineMedicine
Cultured neuronal networkCultured neuronal network
Holocene extinctionHolocene extinction
Alkali metalAlkali metal
Species distributionSpecies distribution
BrassicaceaeBrassicaceae
ReptileReptile
World populationWorld population
Observational learningObservational learning
Competitive inhibitionCompetitive inhibition
Invasive speciesInvasive species
ParrotParrot
White-tailed eagleWhite-tailed eagle
AltruismAltruism
Web Ontology LanguageWeb Ontology Language
Brown ratBrown rat
Glycogen phosphorylaseGlycogen phosphorylase
Science in the Age of EnlightenmentScience in the Age of Enlightenment
IsotretinoinIsotretinoin
Artificial cardiac pacemakerArtificial cardiac pacemaker
BiodieselBiodiesel
StrepsirrhiniStrepsirrhini
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Biological AvailabilityBiopharmaceuticsAuthorshipKnowledge BasesEditorial PoliciesScientific MisconductPublishingAluminumDiatomsSiliconGallionellaceaeSilicic AcidPhosphorusOligochaetaPolycyclic Hydrocarbons, AromaticSoil PollutantsSoilDrugs, EssentialSoil MicrobiologyIndustryGraphiteNanostructuresNanotechnologyTitaniumNanocompositesAccess to InformationPlasmaTasmaniaComputer SimulationResearchModels, BiologicalAlgorithmsRegression AnalysisModels, TheoreticalChemical TerrorismTerrorismVariola virusEmergency RespondersStrategic StockpileChemical WarfarePublic Health Administration
WikiGenes - Biological AvailabilityWikiGenes - Biological Availability
The effect of stage of maturity on the biological availability of magnesuim from wheat and orchardgrass fed to sheepThe effect of stage of maturity on the biological availability of magnesuim from wheat and orchardgrass fed to sheep
Biological availability of sediment phosphorus inputs to the lower Great Lakes (Book, 1985) [WorldCat.org]Biological availability of sediment phosphorus inputs to the lower Great Lakes (Book, 1985) [WorldCat.org]
Federal Register :: Availability of an Environmental Assessment for a Biological Control Agent for Old World...Federal Register :: Availability of an Environmental Assessment for a Biological Control Agent for Old World...
Resource availability and fitness traits | Proceedings of the Royal Society of London B: Biological SciencesResource availability and fitness traits | Proceedings of the Royal Society of London B: Biological Sciences
Federal Register :: Draft Guidance for Industry on General Considerations for Pediatric Pharmacokinetic Studies...Federal Register :: Draft Guidance for Industry on General Considerations for Pediatric Pharmacokinetic Studies...
Influence of tensides and lipophilic substrates on the biological availability of polycyclic aromatic hydrocarbons (PAHs);...Influence of tensides and lipophilic substrates on the biological availability of polycyclic aromatic hydrocarbons (PAHs);...
Silicon, aluminium and the biological availability of phosphorus in algae | Proceedings of the Royal Society of London B:...Silicon, aluminium and the biological availability of phosphorus in algae | Proceedings of the Royal Society of London B:...
Influence of magnesium stearate on the dissolution and biological availability of sulphadiazine tablet formulations ...Influence of magnesium stearate on the dissolution and biological availability of sulphadiazine tablet formulations ...
Biological Sciences - Doctor of Philosophy - Thesis based | Page 4 | University of CalgaryBiological Sciences - Doctor of Philosophy - Thesis based | Page 4 | University of Calgary
Biological Sciences | Undergraduate Degrees | Study Here | The University of AberdeenBiological Sciences | Undergraduate Degrees | Study Here | The University of Aberdeen
Biological Sciences - Master of Science - Thesis based | Page 3 | University of CalgaryBiological Sciences - Master of Science - Thesis based | Page 3 | University of Calgary
Characterization of PAH-contaminated soils focusing on availability, chemical composition and biological effectsCharacterization of PAH-contaminated soils focusing on availability, chemical composition and biological effects
YOABS: yet other aligner of biological sequences--an efficient linearly scaling nucleotide aligner. - PubMed - NCBIYOABS: yet other aligner of biological sequences--an efficient linearly scaling nucleotide aligner. - PubMed - NCBI
DA 1.0: parameter estimation of biological pathways using data assimilation approach. - PubMed - NCBIDA 1.0: parameter estimation of biological pathways using data assimilation approach. - PubMed - NCBI
Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the...Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the...
Biological Effects of Plasma-Based Graphene Oxide Deposition on TitaniumBiological Effects of Plasma-Based Graphene Oxide Deposition on Titanium
Principal process analysis of biological models | SpringerLinkPrincipal process analysis of biological models | SpringerLink
USC02] 21 USC CHAPTER 9, SUBCHAPTER VII, Part C, subpart 8: fees relating to biosimilar biological productsUSC02] 21 USC CHAPTER 9, SUBCHAPTER VII, Part C, subpart 8: fees relating to biosimilar biological products
DynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks | SpringerLinkDynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks | SpringerLink
Frontiers | Learning Causal Biological Networks With the Principle of Mendelian Randomization | GeneticsFrontiers | Learning Causal Biological Networks With the Principle of Mendelian Randomization | Genetics
Frontiers | Biological Synthesis of CdS/CdSe Core/Shell Nanoparticles and Its Application in Quantum Dot Sensitized Solar Cells...Frontiers | Biological Synthesis of CdS/CdSe Core/Shell Nanoparticles and Its Application in Quantum Dot Sensitized Solar Cells...
Flowtrace: simple visualization of coherent structures in biological fluid flows | Journal of Experimental BiologyFlowtrace: simple visualization of coherent structures in biological fluid flows | Journal of Experimental Biology
S317 | Biological Science | Open UniversityS317 | Biological Science | Open University
Modelling Biological Data (KSM304) - Courses & Units - University of Tasmania, AustraliaModelling Biological Data (KSM304) - Courses & Units - University of Tasmania, Australia
Certificate Wildlife Ecology and Management | Biological SciencesCertificate Wildlife Ecology and Management | Biological Sciences
Author: Dai, Li-Shang / Journal: International journal of biological macromolecules / Publication Year: 2017 / Subject:...Author: 'Dai, Li-Shang' / Journal: International journal of biological macromolecules / Publication Year: 2017 / Subject:...
Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems | BMC Genomics | Full...Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems | BMC Genomics | Full...
Biological and Chemical Terrorism:Strategic Plan for Preparedness and ResponseBiological and Chemical Terrorism:Strategic Plan for Preparedness and Response
Difference between revisions of Biofilms on food preparation surfaces - microbewikiDifference between revisions of "Biofilms on food preparation surfaces" - microbewiki
Earn your Masters in Biology from NAU | Biological SciencesEarn your Master's in Biology from NAU | Biological Sciences
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Biological AvailabilityBiopharmaceuticsAuthorshipKnowledge BasesEditorial PoliciesScientific MisconductPublishingAluminumDiatomsSiliconGallionellaceaeSilicic AcidPhosphorusOligochaetaPolycyclic Hydrocarbons, AromaticSoil PollutantsSoilDrugs, EssentialSoil MicrobiologyIndustryGraphiteNanostructuresNanotechnologyTitaniumNanocompositesAccess to InformationPlasmaTasmaniaComputer SimulationResearchModels, BiologicalAlgorithmsRegression AnalysisModels, TheoreticalChemical TerrorismTerrorismVariola virusEmergency RespondersStrategic StockpileChemical WarfarePublic Health Administration
MetabolismSciencesPOLYCYCLIC AROMATIC HYDHistory of Biological WarfareControl of BiologicalMolecularCharacterizationEcologicalVariety of biologicalBiologyGenesImpactsOrganicAnthropologyGenomicsBehaviourDiversityHumansInvestigateAbstractSamplesInfrastructureBioinformaticsPsychiatryDataClinicalTraitsAnalysis of biologicalChemical and biologicalNitrogenPAHsResearchSequencingCertain biologicalImportant biologicalQuantitativeVisualizationInfluenceStudyPhysicalPrinciplesHandbookUniversityMagnesiumInorganicMultidimensionalAffectsGraduateDetectionEffectsWeaponsSystemsConceptsAspects
Metabolism1
  • In two metabolism trials with 18 wether lambs, the biological availability of magnesium was determined for the two forages cut at three stages of maturity. (vt.edu)
Sciences17
  • Thank you for your interest in spreading the word on Proceedings of the Royal Society of London B: Biological Sciences. (royalsocietypublishing.org)
  • Message Body (Your Name) thought you would like to see the Proceedings of the Royal Society of London B: Biological Sciences web site. (royalsocietypublishing.org)
  • Graduate study in Biological Sciences puts students on the front lines of discovery. (ucalgary.ca)
  • A PhD in biological sciences is usually considered a final degree. (ucalgary.ca)
  • Find new ways to pursue your passion for life in the University of Calgary's Biological Sciences department. (ucalgary.ca)
  • A master's degree in biological sciences will give you the pre-requisite for a PhD. (ucalgary.ca)
  • The zebrafish facility within the School of Biological and Chemical Sciences at QMUL is dedicated to the maintenance of wild type, mutant and transgenic stock lines (for available lines please contact facility manager). (qmul.ac.uk)
  • The biological sciences encompass numerous cutting-edge disciplines, with each offering a multitude of exciting career paths. (nau.edu)
  • Our Master of Science program helps you move further down one of those paths by training you in the biological sciences through coursework and research experience. (nau.edu)
  • The Biology M.S. program prepares students for research-focused professions in the biological sciences, emphasizing the development of a students' ability to develop experimental approaches that accurately capture information to solve questions and problems in their biological field of study. (nau.edu)
  • Geneticists study these processes in all types of organisms and discover how errors in them can cause disease, and they help discover how genes work across the biological sciences. (le.ac.uk)
  • By studying genetics alongside options in other biological sciences, you will be able to apply your knowledge across the boundaries of traditional disciplines and gain a valuable and powerful asset in scientific environments and in many other walks of life. (le.ac.uk)
  • The first three years of this course are identical to the Biological Sciences (Genetics) BSc , including the option to spend a Year in Industry or a Year Abroad between Years 2 and 3. (le.ac.uk)
  • The analytical and critical skills you acquire by studying an MBiolSci in Biological Sciences are particularly valued by PhD supervisors, researchers and employers in non-scientific fields. (le.ac.uk)
  • In addition, students become qualified to pursue graduate studies in any of several areas of study within the Biological Sciences and the health professions. (wiu.edu)
  • Spectroscopy for the Biological Sciences provides students and professionals with a working knowledge of the physical chemical aspects of spectroscopy, along with their applications to important biological problems. (wiley.com)
  • He is author of Thermodynamics and Kinetics for the Biological Sciences (also from Wiley) and more than 200 research articles. (wiley.com)
POLYCYCLIC AROMATIC HYD1
  • The risks associated with a soil contaminated by polycyclic aromatic hydrocarbons (PAHs) are generally assessed by measuring individual PAHs in the soil and correlating the obtained amounts to known adverse biological effects of the PAHs. (eugris.info)
History of Biological Warfare1
Control of Biological3
  • SMMC7721, Bel-7402, and MHCC97 human liver cancer cells used in this work were commercially available from the Beijing National Institute for the Control of Biological and Pharmaceutical Products (China). (hindawi.com)
  • As with emerging infectious diseases, early detection and control of biological or chemical attacks depends on a strong and flexible public health system at the local, state, and federal levels. (cdc.gov)
  • He's a professor of chemistry at Rutgers University who has long called for better control of biological research that could be misused. (npr.org)
Molecular9
  • they develop rigorous expertise in everything from foundational theory and the study of evolution to cutting-edge research methodologies as they investigate a broad range of biological problems ranging from the molecular level to the biosphere. (ucalgary.ca)
  • The availability and bioavailability of contaminants in soil also has to be studied further, and such future studies should focus on the molecular interactions between the contaminants and different compartments of the soil. (eugris.info)
  • Such studies would generate the data needed for molecular-based modelling of availability and bioavailability, which would be a big step forward compared to current risk assessment practices. (eugris.info)
  • MRPC learns a causal biological network efficiently and robustly from integrating individual-level genotype and molecular phenotype data, in which directed edges indicate causal directions. (frontiersin.org)
  • This module explores a range of advanced topics in biological science from evolution to cell and molecular biology. (open.ac.uk)
  • This unit applies the core principles of chemistry, molecular structure and chemical reactivity to biological molecules. (edu.au)
  • Biological Science covers major aspects of biology and molecular science across a wide range of organisms from bacteria and fungi to humans and plants. (le.ac.uk)
  • Here, all-atom molecular dynamics simulations are leveraged to investigate the capsid without symmetry bias, enabling study of capsid flexibility and its implications for biological function and cryo-EM resolution limits. (elifesciences.org)
  • In order to identify the molecular mechanism by which CD90 affects the biological behavior and energy metabolism of gastric cancer cells, the present study used Cell Counting Kit‑8 assays, lactate concentration determination and ATP content determination. (spandidos-publications.com)
Characterization1
  • The technique is based purely on image processing of the input data, rather than numerical reconstruction of scalar fields like vorticity, allowing it to be used as a straightforward 'first pass' characterization technique for biological systems where traditional techniques are either unnecessary to support qualitative observations or prohibitively difficult because of the length and time scales involved. (biologists.org)
Ecological3
  • With massive increases in the availability of ecological and other kinds of biological data, skill in developing models to describe and understand relationships in data and extrapolate beyond existing data, and an understanding of the nuances of particular kinds of data, is fundamental in modern biological research. (edu.au)
  • The biological and ecological factors liable to induce a change in the radio-sensitivity of a species are undoubtedly responsible for the large fluctuations observed during radio-biological experiments. (osti.gov)
  • Influence des facteurs biologiques et ecologiques sur la radiosensibilite des animaux de laboratoire} author = {Guenet, J L, and Legeay, G} abstractNote = {The biological and ecological factors liable to induce a change in the radio-sensitivity of a species are undoubtedly responsible for the large fluctuations observed during radio-biological experiments. (osti.gov)
Variety of biological3
Biology4
  • We contend that a possible hitherto unrecognized mechanism of silicon essentiality in biology is to increase the biological availability of phosphorus in the presence of aluminium. (royalsocietypublishing.org)
  • Anthropology 362, on the other hand, addresses itself to two main problem areas where race is concerned: (1) the common concept of race has an inadequate foundation in biology and must be dispensed with before we can make sense out of the very real aspects of human biological variation. (umich.edu)
  • 2) If the common concept of race has an inadequate biological base, how did we get stuck with our generally held assumptions when it would appear that they owe more to folklore than to biology? (umich.edu)
  • With a minimum of mathematics and a strong focus on applications to biology, this book will prepare current and future professionals to better understand the quantitative interpretation of biological phenomena and to utilize these tools in their work. (wiley.com)
Genes1
  • The enormous increase in scalability it provides empowers users to study complex and previously unassailable gene-set associations between genes and their biological functions in a hierarchical fashion and on a genome-wide scale. (biomedcentral.com)
Impacts4
  • Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. (clinicaltrials.gov)
  • In this study, we performed an analysis of inter-regional and inter-annual differences in temperature (T) conditions associated with MMEs of the red gorgonian Paramuricea clavata by analyzing high resolution T time series (hourly records for 3 to 8 years) from four regions of the NW Mediterranean with differing hydrological conditions and biological impacts. (plos.org)
  • This Funding Opportunity Announcement (FOA) is to promote the development and initial clinical validation of objective biological measures to be used for prognosing, and monitoring recovery of adolescents who either clinically present with or are at risk for developing prolonged/persistent concussive symptoms following exposure to repetitive head impacts and/or concussion. (nih.gov)
  • discovering, characterizing the selectivity and sensitivity, and externally validating biological measures to be used for assessing, prognosing, and monitoring recovery of adolescents who either clinically present with or are at risk for developing prolonged/persistent concussive symptoms following exposure to repetitive head impacts and/or concussion. (nih.gov)
Organic2
  • investigation of the influence of tensides and other dissolved organic compounds on the biological availability and degradation of PAHs. (osti.gov)
  • However, the link between the chemical analyses and the biological tests could be improved as as an organic solvent that solubilised virtually all of the contaminants was used during the chemical analysis while the biological tests were performed in an aqueous solution with limited solubility for a number of compounds. (eugris.info)
Anthropology2
Genomics1
  • Advances in such fields as proteomics and genomics place new demands on students and professionals to be able to apply quantitative concepts to the biological phenomena that they are studying. (wiley.com)
Behaviour3
Diversity1
Humans1
Investigate3
Abstract1
  • abstract = "The effect of glucose and other monosaccharide availability in culture medium on production of antibody by human hybridomas has been studied. (elsevier.com)
Samples7
Infrastructure2
  • Evaluation of this vulnerability has focused on the role public health will have detecting and managing the probable covert biological terrorist incident with the realization that the U.S. local, state, and federal infrastructure is already strained as a result of other important public health problems. (cdc.gov)
  • The public health infrastructure must be prepared to prevent illness and injury that would result from biological and chemical terrorism, especially a covert terrorist attack. (cdc.gov)
Bioinformatics1
  • Each biological problem is accompanied by precise formulations, providing graduate students and researchers in bioinformatics and computer science with a powerful toolkit for the emerging applications of high-throughput sequencing. (cambridge.org)
Psychiatry1
Data11
  • The validity of such a risk estimation is dependent on the presence of additional compounds, the availability of the compounds (including the PAHs), and the methods used to correlate the measured chemical data and biological effects. (eugris.info)
  • DA 1.0: parameter estimation of biological pathways using data assimilation approach. (nih.gov)
  • 5) The term 'biosimilar biological product development meeting' means any meeting, other than a biosimilar initial advisory meeting, regarding the content of a development program, including a proposed design for, or data from, a study intended to support a biosimilar biological product application. (house.gov)
  • The integrated data from various online databases makes it easy to identify the biological relevance of nodes in the network. (springer.com)
  • However, the regulatory ERA framework could be improved by (i) inclusion of the environment in the risk-benefit analysis for human pharmaceuticals, (ii) improvement of risk management options, (iii) generation of data on existing pharmaceuticals, and (iv) improving the availability of ERA data. (royalsocietypublishing.org)
  • In order to minimize the quantity of pharmaceuticals in the environment these should aim to (i) improve the existing legislation for pharmaceuticals, (ii) prioritize pharmaceuticals in the environment and (iii) improve the availability and collection of pharmaceutical data. (royalsocietypublishing.org)
  • The new method is streamlined, efficient, and particularly well-suited to the study of huge and diverse biological data. (biomedcentral.com)
  • Innovative Formalism for Biological Data Analysis. (igi-global.com)
  • This book constitutes the refereed proceedings of the 5th International Symposium on Biological and Medical Data Analysis, ISBMDA 2004, held in Barcelona, Spain in November 2004. (barnesandnoble.com)
  • Statistical Methods and Tools for Biological and Medical Data Analysis. (barnesandnoble.com)
  • The collected biological data set is also used by the Baltic Fisheries Assessment Working Group (ICES) to assess the flounder stocks size in Subdivision 25. (bodc.ac.uk)
Clinical1
Traits5
  • The availability of resources strongly influences an individual's ability to modulate investment in sexually selected traits. (royalsocietypublishing.org)
  • As the production and maintenance of traits mediated by pre- and postcopulatory sexual selection is energetically demanding [ 12 , 13 ], an increased investment in traits subject to both episodes of sexual selection can be expected under conditions of high resource availability. (royalsocietypublishing.org)
  • By contrast, under limitation an increased allocation in one function often results in a decreased resource availability for alternative functions [ 14 ], leading to one of the major predictions of sperm competition theory that a male's investment should be traded-off between pre- and postcopulatory traits [ 15 ]. (royalsocietypublishing.org)
  • Experimental manipulation of diet is a suitable approach to explore the impact of variation in resource availability on the expression of pre- and postcopulatory traits and their interrelationship. (royalsocietypublishing.org)
  • These will be contrasted with the biological traits that show regional clustering but which have no adaptive value and cannot therefore be hierarchically arranged. (umich.edu)
Analysis of biological1
  • We consider for this approach fuzzy set as a formalism of analysis of biological signals processing and we propose to be accomplished this goal by developing fuzzy operators for filtering the noise of biological signals measurement. (igi-global.com)
Chemical and biological1
Nitrogen3
  • Description: Molybdenum, Phosphorous, and Nitrogen Availability Control Rates of Biological N2-fixation in Boreal Peatlands / Katherine Dynarski. (villanova.edu)
  • Key chemical concepts such as bonding and structure (e.g. chirality) will be used to highlight the function of biological building blocks (lipids, carbohydrates, amino acids and the nitrogen bases) of large cellular molecules like proteins, DNA and RNA. (edu.au)
  • Our study therefore proposes a subsequent process of protein and partial cellular degradation caused by mutation of silk protein, which might be helpful for understanding its impact of the silk gland biological process, and further exploration the re-allocation of nitrogen in the silkworm. (biomedcentral.com)
PAHs1
  • It can be concluded from the results presented in the included papers that the PAHs in the studied soils from industrial sites were not generally physically trapped in soil material, indicating that the availability of the PAHs was not restricted in this sense. (eugris.info)
Research5
  • Weekly guest lectures about current research helps you to see how basic biological concepts are applied to real world problems. (abdn.ac.uk)
  • Communicate biological knowledge, including results of research undertakings, and the rationale underpinning their conclusions, to specialist and non-specialist audiences clearly and unambiguously. (nau.edu)
  • The government released a new policy on how to handle legitimate biological research that could be misused in the wrong hands. (npr.org)
  • And a new policy by the Obama administration aims to tighten oversight over potentially high-risk biological research. (npr.org)
  • This course examines key research findings and implications about the biological basis for addiction and mental health problems, including the causes, symptoms and course of addictions and mental illness, as well as drug classes and various drugs of abuse. (centennialcollege.ca)
Sequencing1
Certain biological1
  • Nevertheless, because of certain biological properties of UCB compared with bone marrow, UCB cells will grow or "engraft" in most patients and result in reconstitution of the haematopoietic and immune cells. (mja.com.au)
Important biological1
  • Its application has enabled researchers to address important biological questions, often for the first time. (cambridge.org)
Quantitative1
Visualization3
Influence1
  • Influence of magnesium stearate on the dissolution and biological availability of sulphadiazine tablet formulations [proceedings]. (semanticscholar.org)
Study2
  • Australian citizens, permanent residents and international students studying outside Australia may have the choice of full-time, part-time and external study, depending on course availability and in-country requirements. (edu.au)
  • Because her topic is a mixture of civil and biological engineering she's able to make practical use of her study and classes such as hydrology, fluid mechanics and hydraulics, statics and geographic information systems. (ncat.edu)
Physical2
Principles1
  • Medical Science allows you to select specialist modules that focus more closely on the application of biological principles to medicine. (le.ac.uk)
Handbook4
  • Save 12% on the Handbook of Biological Confocal Microscopy (The Language of Science) by Springer at Translate This Blog. (translateth.is)
  • Known as the USAMRIID Blue Book, this invaluable handbook supplies basic summary and treatment information quickly for the healthcare provider on the front lines of a biological incident. (gpo.gov)
  • The purpose of this handbook is to serve as a concise, pocket-sized manual that can be pulled off the shelf (or from a pocket) in a crisis to guide medical personnel in the prophylaxis and management of biological casualties. (gpo.gov)
  • The Medical Management of Biological Casualties Handbook, which has been known as the "Blue Book" has been enormously successful. (gpo.gov)
University4
  • The University reserves the right to amend or remove courses and unit availabilities, as appropriate. (edu.au)
  • At the University of Leicester, we offer seven Biological Science subjects and four Medical Bioscience subjects, all as both BSc (three years) and MBiolSci (four years), plus a Foundation Year option, giving you an impressive range of 23 different courses to choose from. (le.ac.uk)
  • Dr. Godfrey Gayle, a professor of biological engineering, has secured a $400,000 contract with the U.S. Department of Agriculture's Natural Resources Conservation Service to provide scholarships and other support to students studying biological engineering at North Carolina Agricultural and Technical State University. (ncat.edu)
  • North Carolina A&T State University senior, biological engineering student Madeline Keefer will spend nine months studying flood management in the Netherlands thanks to a Fulbright U.S. Student Programs Grant jointly sponsored by the Netherland-America Foundation. (ncat.edu)
Magnesium3
Inorganic1
  • Maha M. Hady ,Hoda A. Ali , Biological availability of manganese from several inorganic sources in Fayoumi chicks, Alex. (who.int)
Multidimensional1
Affects2
  • To test how dietary resource availability affects sexual ornamentation, sperm quality and their interrelationship in three-spined sticklebacks ( Gasterosteus aculeatus ), full-sibling groups were raised under three conditions differing in food quantity and/or quality (i.e. carotenoid content): (i) high-quantity/high-quality, (ii) high-quantity/low-quality or (iii) low-quantity/low-quality. (royalsocietypublishing.org)
  • These results suggest that change of glucose availability affects the antigen-binding activity of the antibody via the alteration of the glycosylation. (elsevier.com)
Graduate1
  • The two-year contract seeks to increase enrollment and improve retention of undergraduate and graduate students studying biological engineering, especially natural resources and agricultural engineering programs in the CAES. (ncat.edu)
Detection2
Effects3
  • The environmental assessment considers the effects of, and alternatives to, the release of a nonindigenous gall mite, Floracarus perrepae, for the biological control of Old World climbing fern in Florida. (federalregister.gov)
  • Finally, single compounds from this large set of compounds, which correlated with different biological effects, could be identified using the multivariate technique partial least squares projections to latent structures (PLS). (eugris.info)
  • Additional topics include health promotion measures to cope with biological aging and treatment measures for dysfunctional effects of common health problems. (centennialcollege.ca)
Weapons5
  • The U.S. national civilian vulnerability to the deliberate use of biological and chemical agents has been highlighted by recognition of substantial biological weapons development programs and arsenals in foreign countries, attempts to acquire or possess biological agents by militants, and high-profile terrorist attacks. (cdc.gov)
  • Recovering amphibious forces can be complicated if ashore forces are attacked with chemical, biological, or radiological weapons. (rand.org)
  • Medical professionals learn about effective available medical countermeasures against many of the bacteria, viruses, and toxins that might be used as biological weapons against military forces or civilian communities. (gpo.gov)
  • Since the first edition in 1993, the awareness of biological weapons in the U.S. has increased dramatically. (gpo.gov)
  • In-depth definitions of biological agents, biological weapons, and biological warfare (BW) are included, as well as an appendix of further reading on the subject. (gpo.gov)
Systems2
Concepts1
Aspects1
  • A greater in-depth discussion of the agents covered here may be found in the Army Surgeon General's Borden Institute Textbook of Military Medicine, "Medical Aspects of Biological Warfare" (2007) and in relevant infectious disease, tropical medicine, and disaster management textbooks. (gpo.gov)
Biological Sciences - Doctor of Philosophy - Thesis based | Page 4 | University of Calgary
Biological Sciences - Doctor of Philosophy - Thesis based | Page 4 | University of Calgary (ucalgary.ca)
Biological Sciences - Master of Science - Thesis based | Page 3 | University of Calgary
Biological Sciences - Master of Science - Thesis based | Page 3 | University of Calgary (ucalgary.ca)
Principal process analysis of biological models | SpringerLink
Principal process analysis of biological models | SpringerLink (link.springer.com)
Mapping ecoregions under climate change: a case study from the biological 'crossroads' of three continents, Turkey |...
Mapping ecoregions under climate change: a case study from the biological 'crossroads' of three continents, Turkey |... (link.springer.com)
Difference between revisions of Biofilms on food preparation surfaces - microbewiki
Difference between revisions of "Biofilms on food preparation surfaces" - microbewiki (microbewiki.kenyon.edu)
Peter John Dalby - WWOOF Australia
Peter John Dalby - WWOOF Australia (wwoof.com.au/members/pietro91/)
Hawkesbury River Cottage | WWOOF Australia
Hawkesbury River Cottage | WWOOF Australia (wwoof.com.au/members/hawkesbury/)
Helen Chambers & Julian Flack - WWOOF Australia
Helen Chambers & Julian Flack - WWOOF Australia (wwoof.com.au/members/vb084/)
Aidan Banfield - WWOOF Australia
Aidan Banfield - WWOOF Australia (wwoof.com.au/members/vb071/)
Adhi Bail - WWOOF Australia
Adhi Bail - WWOOF Australia (wwoof.com.au/members/cootharabafarm/)
Bird song biological themes and variations 2nd edition | Animal behaviour | Cambridge University Press
Bird song biological themes and variations 2nd edition | Animal behaviour | Cambridge University Press (cambridge.org)
Genome scale algorithm design biological sequence analysis era high throughput sequencing | Genomics, bioinformatics and...
Genome scale algorithm design biological sequence analysis era high throughput sequencing | Genomics, bioinformatics and... (cambridge.org)
Nonlinear mechanics shells and plates composite soft and biological materials | Solid mechanics and materials | Cambridge...
Nonlinear mechanics shells and plates composite soft and biological materials | Solid mechanics and materials | Cambridge... (cambridge.org)
Public Health Preparedness for Chemical, Biological, Radiological, and Nuclear Weapons | RAND
Public Health Preparedness for Chemical, Biological, Radiological, and Nuclear Weapons | RAND (rand.org)
Understanding trauma integrating biological clinical and cultural perspectives | Health and clinical psychology | Cambridge...
Understanding trauma integrating biological clinical and cultural perspectives | Health and clinical psychology | Cambridge... (cambridge.org)
Handbook bioelectronics directly interfacing electronics and biological systems | Electronic, optoelectronic devices, and...
Handbook bioelectronics directly interfacing electronics and biological systems | Electronic, optoelectronic devices, and... (cambridge.org)
Developing Navy Capability to Recover Forces in Chemical, Biological, and Radiological Hazard Environments | RAND
Developing Navy Capability to Recover Forces in Chemical, Biological, and Radiological Hazard Environments | RAND (rand.org)
Frontiers | Learning Causal Biological Networks With the Principle of Mendelian Randomization | Genetics
Frontiers | Learning Causal Biological Networks With the Principle of Mendelian Randomization | Genetics (frontiersin.org)
Aristotle's Revenge: The Metaphysical Foundations of Physical and Biological Science / Edition 1 by Edward Feser |...
Aristotle's Revenge: The Metaphysical Foundations of Physical and Biological Science / Edition 1 by Edward Feser |... (barnesandnoble.com)
Handbook of Biological Confocal Microscopy (The Language of Science)
Handbook of Biological Confocal Microscopy (The Language of Science) (translateth.is)
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model | Nature...
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model | Nature... (nature.com)
Nathan Lovejoy | Department of Biological Sciences
Nathan Lovejoy | Department of Biological Sciences (utsc.utoronto.ca)
Radiation and Environmental Biophysics - incl. option to publish open access
Radiation and Environmental Biophysics - incl. option to publish open access (springer.com)
Scientists making difference one hundred eminent behavioral and brain scientists talk about their most important contributions ...
Scientists making difference one hundred eminent behavioral and brain scientists talk about their most important contributions ... (cambridge.org)
Modern Engineering Thermodynamics - Textbook with Tables Booklet - 1st Edition
Modern Engineering Thermodynamics - Textbook with Tables Booklet - 1st Edition (elsevier.com)
Bariatric Surgery and Pharmacokinetics of Lisdexamphetamine - Full Text View - ClinicalTrials.gov
Bariatric Surgery and Pharmacokinetics of Lisdexamphetamine - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Molecules | Free Full-Text | Synthesis and Biological Evaluation of Unsymmetrical Curcumin Analogues as Tyrosinase Inhibitors ...
Molecules | Free Full-Text | Synthesis and Biological Evaluation of Unsymmetrical Curcumin Analogues as Tyrosinase Inhibitors ... (mdpi.com)