Biogenic polyamines. Medical search

Biogenic amines having more than one amine group. These are long-chain aliphatic compounds that contain multiple amino and/or imino groups. Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA.

A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.

A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.

A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.

A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.

A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)

A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.

Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.

A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.

An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.

An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.

A foul-smelling diamine formed by bacterial decarboxylation of lysine.

An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-aminopropyl-(1), methylsulfonium salt. It is one of the enzymes responsible for the synthesis of spermidine from putrescine. EC 4.1.1.50.

Organic chemicals which have two amino groups in an aliphatic chain.

Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.

An amino acid produced in the urea cycle by the splitting off of urea from arginine.

An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.

Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.

A plant genus in the family THEACEAE, order THEALES best known for CAMELLIA SINENSIS which is the source of Oriental TEA.

The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

A genus of protozoa, formerly also considered a fungus. Its natural habitat is decaying forest leaves, where it feeds on bacteria. D. discoideum is the best-known species and is widely used in biomedical research.

A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Substances that reduce the growth or reproduction of BACTERIA.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.

Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.

Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.

Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.

A peptide which is a homopolymer of lysine.

An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.

A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.

A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.

The family Sturnidae, in the order PASSERIFORMES. The starling family also includes mynahs and oxpeckers.

Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.

A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.

A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.

Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. (1/216)

We recently generated a transgenic mouse line overexpressing spermidine/spermine N1-acetyltransferase (SSAT) gene under its own promoter. The tissue polyamine pools of these animals were profoundly affected and the mice were hairless from early age. We have now generated another transgenic-mouse line overexpressing the SSAT gene under the control of a heavy-metal-inducible mouse metallothionein I (MT) promoter. Even in the absence of heavy metals, changes in the tissue polyamine pools indicated that a marked activation of polyamine catabolism had occurred in the transgenic animals. As with the SSAT transgenic mice generated previously, the mice of the new line (MT-SSAT) suffered permanent hair loss, but this occurred considerably later than in the previous SSAT transgenic animals. Liver was the most affected tissue in the MT-SSAT transgenic animals, revealed by putrescine overaccumulation, significant decrease in spermidine concentration and >90% reduction in the spermine pool. Even though hepatic SSAT mRNA accumulated to massive levels in non-induced transgenic animals, SSAT activity was only moderately elevated. Administration of ZnSO4 further elevated the level of hepatic SSAT message and induced enzyme activity, but not more than 2- to 3-fold. Treatment of the transgenic animals with the polyamine analogue N1,N11-diethylnorspermine (DENSPM) resulted in an immense induction, more than 40000-fold, of enzyme activity in the liver of transgenic animals, and minor changes in the SSAT mRNA level. Liver spermidine and spermine pools were virtually depleted within 1-2 days in response to the treatment with the analogue. The treatment also resulted in a marked mortality (up to 60%) among the transgenic animals which showed ultrastructural changes in the liver, most notably mitochondrial swelling, one of the earliest signs of cell injury. These results indicated that, even without its own promoter, SSAT is powerfully induced by the polyamine analogue through a mechanism that appears to involve a direct translational and/or heterogenous nuclear RNA processing control. It is likewise significant that overexpression of SSAT renders the animals extremely sensitive to polyamine analogues. (+info)

Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1. (2/216)

Inward rectifying K channels are essential for maintaining resting membrane potential and regulating excitability in many cell types. Previous studies have attributed the rectification properties of strong inward rectifiers such as Kir2.1 to voltage-dependent binding of intracellular polyamines or Mg to the pore (direct open channel block), thereby preventing outward passage of K ions. We have studied interactions between polyamines and the polyamine toxins philanthotoxin and argiotoxin on inward rectification in Kir2.1. We present evidence that high affinity polyamine block is not consistent with direct open channel block, but instead involves polyamines binding to another region of the channel (intrinsic gate) to form a blocking complex that occludes the pore. This interaction defines a novel mechanism of ion channel closure. (+info)

Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells. (3/216)

We investigated the effects of polyamine biosynthesis inhibition on the estrogenic signaling pathway of MCF-7 breast cancer cells using a protein-protein interaction system. Estrogen receptor (ER) linked to glutathione-S-transferase (GST) was used to examine the effects of two polyamine biosynthesis inhibitors, difluoromethylornithine (DFMO) and CGP 48664. ER was specifically associated with a 45 kDa protein in control cells. In cells treated with estradiol, nine proteins were associated with ER. Cells treated with polyamine biosynthesis inhibitors in the absence of estradiol retained the binding of their ER with a 45 kDa protein and the ER also showed low-affinity interactions with a number of cellular proteins; however, these associations were decreased by the presence of estradiol and the inhibitors. When samples from the estradiol+DFMO treatment group were incubated with spermidine prior to GST-ER pull down assay, an increased association of several proteins with ER was detected. The intensity of the ER-associated 45 kDa protein increased by 10-fold in the presence of 1000 microM spermidine. These results indicate a specific role for spermidine in ER association of proteins. Western blot analysis of samples eluted from GST-ER showed the presence of chicken ovalbumin upstream promoter-transcription factor, an orphan nuclear receptor, and the endogenous full-length ER. These results show that multiple proteins associate with ER and that the binding of some of these proteins is highly sensitive to intracellular polyamine concentrations. Overall, our results indicate the importance of the polyamine pathway in the gene regulatory function of estradiol in breast cancer cells. (+info)

Influence of polyamines on DNA binding of heat shock and activator protein 1 transcription factors induced by heat shock. (4/216)

Polyamine depletion, obtained in FAO cells with specific inhibitors of biosynthetic enzymes, prevents or decreases the accumulation of hsp 70 mRNA following heat shock [Desiderio et al., Hepatology 24 (1996) 150-156]. The present study shows that under conditions of spermidine depletion caused by alpha-difluoromethylornithine, the DNA binding capacity of the transcription factor HSF induced by heat shock undergoes a severe and prompt deactivation. Replenishment of the spermidine pool before heat shock re-establishes the DNA binding activity of HSF and the inducibility of hsp 70 mRNA. Similar to HSF, but with a different time-course, the DNA binding of the transcription factor AP-1 activated by heat shock is also impaired in spermidine-depleted cells and reversed by exogenous spermidine. STAT3 provides an example of a transcription factor slightly activated by heat shock but insensitive to polyamine decrease. (+info)

Inhibition of polyamine synthesis arrests trichomonad growth and induces destruction of hydrogenosomes. (5/216)

Trichomonad parasites such as Tritrichomonas foetus produce large amounts of putrescine (1,4-diaminobutane), which is transported out of the cell via an antiport mechanism which results in the uptake of a molecule of spermine. The importance of putrescine to the survival of the parasite and its role in the biology of T. foetus was investigated by use of the putrescine analogue 1, 4-diamino-2-butanone (DAB). Growth of T. foetus in vitro was significantly inhibited by 20 mM DAB, which was reversed by the addition of exogenous 40 mM putrescine. High-performance liquid chromatography analysis of 20 mM DAB-treated T. foetus revealed that putrescine, spermidine, and spermine levels were reduced by 89, 52, and 43%, respectively, compared to those in control cells. The DAB treatment induced several ultrastructural alterations, which were primarily observed in the redox organelles termed hydrogenosomes. These organelles were progressively degraded, giving rise to large vesicles that displayed material immunoreactive with an antibody to beta-succinyl-coenzyme A synthetase, a hydrogenosomal enzyme. A protective role for polyamines as stabilizing agents in the trichomonad hydrogenosomal membrane is proposed. (+info)

Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport. (6/216)

The antizyme family consists of closely homologous proteins believed to regulate cellular polyamine pools. Antizyme1, the first described, negatively regulates ornithine decarboxylase, the initial enzyme in the biosynthetic pathway for polyamines. Antizyme1 targets ornithine decarboxylase for degradation and inhibits polyamine transport into cells, thereby diminishing polyamine pools. A polyamine-stimulated ribosomal frameshift is required for decoding antizyme1 mRNA. Recently, additional novel conserved members of the antizyme family have been described. We report here the properties of one of these, antizyme2. Antizyme2, like antizyme1, binds to ornithine decarboxylase and inhibits polyamine transport. Using a baculovirus expression system in cultured Sf21 insect cells, both antizymes were found to accelerate ornithine decarboxylase degradation. Expression of either antizyme1 or 2 in Sf21 cells also diminished their uptake of the polyamine spermidine. Both forms of antizyme can therefore function as negative regulators of polyamine production and transport. However, in contrast to antizyme1, antizyme2 has negligible ability to stimulate degradation of ornithine decarboxylase in a rabbit reticulocyte lysate. (+info)

The non-enzymatic hydrolysis of oligoribonucleotides VI. The role of biogenic polyamines. (7/216)

Single-stranded oligoribonucleotides containing UA and CA phosphodiester bonds can be hydrolyzed specifically under non-enzymatic conditions in the presence of spermidine, a biogenic amine found in a wide variety of organisms. In the present study, the rate of oligonucleotide and tRNA(i)(Met)hydrolysis was measured in the presence of spermidine and other biogenic amines. It was found that spermine [H(3)N(+)(CH(2))(3)(+)NH(2)(CH(2))(4)(+)NH(2)(CH(2))(3)(+)NH(3)] and putrescine [H(3)N(+)(CH(2))(4)(+)NH(3)] can replace spermidine [H(3)N(+)-(CH(2))(4)(+)NH(2)(CH(2))(3)(+)NH(3)] to induce the hydrolysis. For all three polyamines, a bell-shaped cleavage rate versus concentration relationship was observed. The maximum rate of hydrolysis was achieved at 0.1, 1.0 and 10 mM spermine, spermidine and putrescine, respectively. Moreover, we found that the hydrolysis requires at least two linked amino groups since two aminoalcohols, 2-aminoethanol and 3-aminopropanol, were not able to induce the cleavage of the phospho-diester bond. The optimal cleavage rate of the oligo-ribonucleotides was observed when amino groups were separated by tri- or tetramethylene linkers. The methylation of the amino groups reduced the ability of diamines to induce oligoribonucleotide hydrolysis. Non-enzymatic cleavage of tRNA(i)(Met)from Lupinus luteus and tRNA(i)(Met)from Escherichia coli demonstrate that both RNAs hydrolyze as expected from principles derived from oligoribonucleotide models. (+info)

Polyamine regulation of plasma membrane phospholipid flip-flop during apoptosis. (8/216)

During apoptosis, phosphatidylserine (PS) is moved from the plasma membrane inner leaflet to the outer leaflet where it triggers recognition and phagocytosis of the apoptotic cell. Although the mechanisms of PS appearance during apoptosis are not well understood, it is thought that declining activity of the aminophospholipid translocase and calcium-mediated, nonspecific flip-flop of phospholipids play a role. As previous studies in the erythrocyte ghost have shown that polyamines can alter flip-flop of phospholipids, we asked whether alterations in cellular polyamines in intact cells undergoing apoptosis would affect PS appearance, either by altering aminophospholipid translocase activity or phospholipid flip-flop. Cells of the human leukemic cell line, HL-60, were incubated with or without the ornithine decarboxylase inhibitor, difluoromethylornithine (DFMO), and induced to undergo apoptosis by ultraviolet irradiation. Whereas DFMO treatment resulted in profound depletion of putrescine and spermidine (but not spermine), it had no effect on caspase activity, DNA fragmentation, or plasma membrane vesiculation, typical characteristics of apoptosis. Notably, DFMO treatment prior to ultraviolet irradiation did not alter the decline in PS inward movement by the aminophospholipid translocase as measured by the uptake of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS detected in the flow cytometer. Conversely, the appearance of endogenous PS in the plasma membrane outer leaflet detected with fluorescein isothiocyanate-labeled annexin V and enhanced phospholipid flip-flop detected by the uptake of 1-palmitoyl-1-[6-[(7-nitro-2-1, 3-benzoxadiazol-4-yl)aminocaproyl]-sn-glycero-3-phosphocholine (NBD-PC) seen during apoptosis were significantly inhibited by prior DFMO treatment. Importantly, replenishment of spermidine, by treatment with exogenous putrescine to bypass the metabolic blockade by DFMO, restored both enhanced phospholipid flip-flop and appearance of PS during apoptosis. Such restoration was seen even in the presence of cycloheximide but was not seen when polyamines were added externally just prior to assay. Taken together, these data show that intracellular polyamines can modulate PS appearance resulting from nonspecific flip-flop of phospholipids across the plasma membrane during apoptosis. (+info)

... concentration of DNA can be artificially increased by adding condensing agents such as cobalt hexamine and biogenic polyamines ... Raae AJ, Kleppe RK, Kleppe K (December 15, 1975). "Kinetics and effect of salts and polyamines on T4 polynucleotide ligase". ...

https://en.wikipedia.org/wiki/Ligation_(molecular_biology)

Trimethylamine N-oxide Indoleamines Melatonin 6-Hydroxymelatonin N-Acetylserotonin Examples of notable biogenic polyamines ... A biogenic amine is a biogenic substance with one or more amine groups. They are basic nitrogenous compounds formed mainly by ... However, food containing high amounts of biogenic amines may have toxicological effects. Biogenic amines are naturally present ... Biogenic amines can be found in all foods containing proteins or free amino acids and are found in a wide range of food ...

https://en.wikipedia.org/wiki/Biogenic_amine

"Origin of supposedly biogenic magnetite in the Martian meteorite Allan Hills 84001" (PDF).. ... "KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis". Nature Communications. 6 ... Biomagnetism is usually related to the presence of biogenic crystals of magnetite, which occur widely in organisms.[24] These ... Hence, the presence of trace levels of biogenic magnetite in virtually all human tissues examined suggests that similar ...

https://en.wikipedia.org/wiki/Magnetite

Polyamine metabolism. Agmatine is a precursor for polyamine synthesis, competitive inhibitor of polyamine transport, inducer of ... Huisman H, Wynveen P, Nichkova M, Kellermann G (August 2010). "Novel ELISAs for screening of the biogenic amines GABA, glycine ... Satriano J (July 2004). "Arginine pathways and the inflammatory response: interregulation of nitric oxide and polyamines: ... synthesis and polyamine metabolism and this provides bases for further research into potential applications. Agmatine was ...

https://en.wikipedia.org/wiki/Agmatine

The biogenic silica composing the cell wall is synthesised intracellularly by the polymerisation of silicic acid monomers. This ... including a higher number of polyamines than most genomes, as well as three distinct silica transport genes. In a phylogenetic ... Other researchers have suggested that the biogenic silica in diatom cell walls acts as an effective pH buffering agent, ... Kidder, David L.; Erwin, Douglas H. (2001). "Secular Distribution of Biogenic Silica through the Phanerozoic: Comparison of ...

https://en.wikipedia.org/wiki/Diatom

Sarcosine; Polyamine site agonists: Neomycin. *Spermidine. *Spermine; Other positive allosteric modulators: 24S- ... Biogenic amines: Monoamines: 6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ...

https://en.wikipedia.org/wiki/Spaglumic_acid

Sarcosine; Polyamine site agonists: Neomycin. *Spermidine. *Spermine; Other positive allosteric modulators: 24S- ... Biogenic amines. Monoamines. *6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ...

https://en.wikipedia.org/wiki/Glycine

Here, we briefly summarize the current knowledge on the physiological roles of biogenic polyamines and the role of Ero1 at the ... In this review, we focus on the roles of biogenic polyamines and oxidative protein folding in the endoplasmic reticulum (ER) ... Polyamines act as ROS scavengers, however, their catabolism is accompanied by H2O2 production. Hydrogen peroxide is also ... 2. Biogenic Polyamines at the Crossroads of Redox Status. Biogenic polyamines are low molecular weight compounds composed of an ...

https://www.mdpi.com/1422-0067/19/4/1219/htm

Several polynuclear Pt(II) chelates with biogenic polyamines were synthesized and screened for their potential ... Cytotoxic Activity of Metal Complexes of Biogenic Polyamines: Polynuclear Platinum(II) Chelates. por. ...

https://estudogeral.uc.pt/handle/10316/45151?mode=full

Polyamines and biogenic amines are chemicals derived from amino acids. Polyamines are involved in intracellular signals. ... Green Tea, Polyamines and Biogenic Amines.. Posted on January 14, 2014. by Dr. Gary Pack ... Epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) targets the pathways of biogenic amines and polyamines. ... Miscellaneous: Biogenic amines, Caffeine, Cyclooxygenase, Dopamine, l-DOPA, Lipoxygenase inhibitor, Methylxanthine, ...

https://www.rainbow.coop/nutritional-library/miscellaneous/cyclooxygenase/

https://www.rainbow.coop/nutritional-library/condition/parkinsons-disease/page/2/

A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth ... Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally ... Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism. ...

https://www.rcsb.org/ligand/SPM

The role of biogenic polyamines. Nucleic Acids Res 27:3931-3937PubMedCrossRefGoogle Scholar ...

https://link.springer.com/article/10.1007%2Fs11084-011-9239-0

Given that polyamines can interact with many molecules, it is not surprising that they affect aging via several mechanisms. ... Molecular basis of the anti-aging effect of spermidine and other natural polyamines - a mini-review Gerontology. 2014;60(4): ... Objectives: An up-to-date overview of the so far identified mechanisms of action of spermidine and other polyamines on aging is ... Methods: Studies of aging and of the molecular effects of polyamines in general and spermidine in particular are used to ...

https://pubmed.ncbi.nlm.nih.gov/24481223/

Biogenic Polyamines / analysis * DNA, Bacterial / genetics * DNA, Ribosomal / genetics * Fatty Acids / analysis ...

https://pubmed.ncbi.nlm.nih.gov/11491340/?dopt=Abstract

... coli polyamine biosynthesis pathway. C. Analysis of polyamine content in E. coli polyamine mutants grown on antibiotic-free ... Exposure to biogenic ammonia increases the intracellular pool of E. coli polyamines. A. Effect of supplementation of LB agar ... Here we show that bacterial uptake and metabolism of biogenic ammonia increases the intracellular level of polyamines and ... the use of combined multiple mutations of polyamine synthesis genes demonstrated that the reduction or absence of polyamines ( ...

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2011.07724.x/full

... and polyamine. It is clear that CD spectroscopy is extremely sensitive and relatively inexpensive, as compared with other ... DNA interaction with antitumor polyamine analogues: A comparison with biogenic polyamines. Biomacromolecules 2008, 9, 2712-2718 ... Ouameur, A.A.; Bourassa, P.; Tajmir-Riahi, H.A. Probing tRNA interaction with biogenic polyamines. RNA 2010, 16, 1968-1979. [ ... Ouameur, A.A.; Tajmir-Riahi, H.A. Structural analysis of DNA interactions with biogenic polyamines and cobalt(III)hexamine ...

http://www.mdpi.com/1422-0067/13/3/3394/htm

... biogenic polyamine; anti-oxidant)19, niacinamide (vitamin B3; neuroprotective)20, and squalene (terpenoid phenolic; anti- ...

https://joannenova.com.au/2021/07/men-worse-for-climate-change-than-women-so-if-enough-transition-will-that-stop-the-floods/?replytocom=2445769

Biogenic amines (BA) are potentially unsafe nitrogenous compounds that result from the decarboxylation of some amino acids. ... Biogenic amines (BA) are potentially unsafe nitrogenous compounds that result from the decarboxylation of some amino acids. ... On the other hand, Staphylococcus xylosus and Debaryomyces hansenii strains have been reported to degrade biogenic amines in ... particularly biogenic amines, nitrosamines, polycyclic aromatic hydrocarbons (PAH), and mycotoxins. ...

https://www.frontiersin.org/articles/10.3389/fmicb.2019.00853/full

Biogenic Polyamines without derivatization *Analytical. Related Product：Triart PFP Data No. F130703B_polyamines 2013/10/03 ...

http://www.ymc.co.jp/en/technical/

Tat protein induces spermine oxidase (SMO), an enzyme involved in catabolism of biogenic polyamines, and may impact ... and biogenic polyamines, protein folding in the lumen of endoplasmic reticulum (ER), and so forth [3-7]. The most reactive type ... an enzyme involved in the catabolism of biogenic polyamines [88, 97]. The third relies on mitochondrial dysfunction [98] but ... and A. E. Pegg, "Polyamine catabolism and disease," Biochemical Journal, vol. 421, no. 3, pp. 323-338, 2009. View at: Publisher ...

https://www.hindawi.com/journals/omcl/2016/8910396/

Biogenic polyamines spermine and spermidine participate in numerous cellular processes including transcription, RNA processing ... homogenate on polyamine biosynthesis and polyamine degradation as well as on resulting polyamine levels in HGC-27 human gastric ... METHODS: Dietary polyamine data were available for 188 of 267 patients completing the study. Total dietary polyamine content ... Polyamines are synthesised endogenously and obtained from dietary sources. Here we investigate dietary polyamine intake and ...

http://www.cancerindex.org/geneweb/ODC1.htm

Putrescine is a biogenic polyamine and precursor of spermidine. It is formed via decarboxylation of ornithine or by ... Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. Spermidine has a role in cell growth ... Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine. ...

http://www.thomassci.com/nav/cat1/aminoacids/manufacturer/mpbiomedicals/0

Ramirez, F. J.; Thomas, T. J.; Antony, T.; Ruiz-Chica, J.; Thomas, T.: Effects of aminooxy analogues of biogenic polyamines on ... Antony, T.; Hoyer, W.; Cherny, D. I.; Heim, G.; Jovin, T. M.; Subramaniam, V.: Cellular polyamines promote the aggregation of α ... Formation of DNA nanoparticles in the presence of novel polyamine analogues: a laser light scattering and atomic force ...

https://www.mpibpc.mpg.de/publication-search/106332?person=%2Fpersons%2Fresource%2Fpersons14784

Atmospheric CO_2 captured by biogenic polyamines is transferred as a possible substrate to Rubisco for the carboxylation ...

https://ci.nii.ac.jp/author?q=Hirose+Mina

Certain endogenous biogenic D,L-amino acids, polyamines, and advanced glycation end-products (AGEs) have been detected in ... ...

http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-72.html

Structural analysis of DNA interactions with biogenic polyamines and cobalt(III)hexamine studied by Fourier transform infrared ... Effect of polyamines on mitochondrial F-ATPase from Crithidia fasciculata and Trypanosoma cruzi. ...

https://www.ncbi.nlm.nih.gov/pubmed?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=6151349

Biogenic polyamines promote the aggregation of α‐synuclein and may constitute endogenous agents modulating the pathogenesis of ... A) No polyamine (0), and 100 μM putrescine (1), spermidine (2), spermine (3) and the synthetic polyamines 4‐4‐4 (4) and BE‐4‐4‐ ... A) The different polyamines are designated as in Figure 1. Solid lines, global fits (for each polyamine, assigning the same ... ii) a constant fraction, β, of monomer (free or aggregated) in a polyamine‐liganded form, dictated by polyamine type and ...

http://emboj.embopress.org/content/23/10/2039?ijkey=9f443b0d60b3282bff04b41701fc239e767fce48&keytype2=tf_ipsecsha

E. Standarová, L. Vorlová, and L. Gallas, "The distribution of biogenic amines and polyamines in pheasant meat," Maso ...

https://www.hindawi.com/journals/tswj/2014/364602/ref/

It can also be used for separation of moderately hydrophobic amines, including biogenic amines, alkyldiamines, and polyamines. ... For polyvalent and moderately hydrophobic amines, including diamines and biogenic amines *Optimized for simple acidic gradient ... including biogenic amines and diamines, using simple aqueous eluents and elevated temperature (40 °C). The Dionex IonPac CS17 ... including biogenic amines and diamines, using simple aqueous eluents and elevated temperature (40 °C). The Dionex IonPac CS17 ...

http://www.selectscience.net/products/ionpac-cs17-cation-exchange-column/?prodID=103986

The main mechanism of biogenic formation is the decarboxylation of free amino acids by specific enzymes of microbial origin, ... the production of biogenic amines. The physiological effects of tyramine include peripheral vasoconstriction, increased cardiac ... This chapter discusses the formation and degradation of biogenic amines, their occurrence in foods, their significance in food ... Kalac, P.,, and M. Krizek. 2003. A review of biogenic amines and polyamines in beer. J. Inst. Brew. 109:123-128.. ...

http://www.asmscience.org/content/book/10.1128/9781555815936.ch16

This odor has been associated with increases in several biogenic amines (BAs) that may serve as important biomarkers. Within ... This odor has been associated with increases in several biogenic amines (BAs) that may serve as important biomarkers. Within ... One clinical feature of BV, malodor, has been linked to increases in vaginal biogenic amines (BAs), including the polyamines ... Determining Biogenic Amine Levels Corresponding to CSTs. Sample Set for Measuring Biogenic Amine Levels. Analyses were ...

https://www.frontiersin.org/articles/10.3389/fphys.2015.00253/full

Biogenic Amines;Foods of Animal Origin;Korean Domestic Markets; ... Quantitative Analysis of Biogenic Amines in Raw and Processed ... Biogenic amine and polyamine contents in meat and meat products. J. Agric. Food Chem. 45:2098-2102. ... Distribution of biogenic amines and polyamines in cheese. J. Food Sci. 68(3):750-755. ... Quantitative Analysis of Biogenic Amines in Raw and Processed Foods of Animal Origin on Korean Domestic Market. Min, Joong-Seok ...

http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1DMBP_2004_v17n12_1764

In particular photosensitive polyamines have been recently used to photo-trigger the hybridization/melting of DNA as well as to ... Direct comparison of our results achieved by using photosensitive polyamines with those previously reported for biogenic and ... In particular photosensitive polyamines have been recently used to photo-trigger the hybridization/melting of DNA as well as to ... Probing the binding mechanism of photoresponsive azobenzene polyamine derivatives with human serum albumin M. Deiana, Z. ...

http://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA26033K

Biogenic Amines;Volatile Basic Nitrogen;Beef;Pork;Chicken; ... Relationship between the Concentration of Biogenic Amines and ... Biogenic amine and polyamine contents in meat and meat products. J. Agric. Food Chem. 45:2098-2102. ... Polyamines in food and their consequences for food quality and human health. Trends in Food Sci. Technol. 6:341-346. ... Determination of biogenic amines in fresh unpacked and vacuum-packed beef during storage at 4. $^{\circ}$. C. Food Chem. 74:515 ...

http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1DMBP_2007_v20n8_1278

Putrescine is a biogenic polyamine naturally produced in peri-ovulatory ovaries in all animal species studied thus far. Peri- ...

http://www.xenbase.org/community/person.do?method=display&personId=3915&personName=Liu

Polar amines (alkanolamines and methylamines) and moderately hydrophobic amines (biogenic amines, diamines and polyamines) in ... Moderately low-capacity cation-exchange column for analysis of aliphatic amines, aromatic amines, and polyamines using MSA or ... Gradient separation of polyvalent and more hydrophobic amines, biogenic amines, and diamines. This newer column replaces the ... They are excellent for separations of alkali metals, alkaline earth metals, alkylamines, alkanolamines and biogenic amines. ...

https://www.thermofisher.com/us/en/home/industrial/chromatography/ion-chromatography-ic/ion-chromatography-columns/cation-exchange-ic-columns.html

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. (cancerindex.org)
Putrescine is a biogenic polyamine naturally produced in peri-ovulatory ovaries in all animal species studied thus far. (xenbase.org)
When present in wines in high amount, biogenic amines may cause not only organoleptic defects but also adverse effects in sensitive human individuals, namely due to the toxicity of histamine, tyramine and putrescine. (wikipedia.org)
Biogenic amines such as putrescine, tyramine and cadaverine can potentiate histamine toxicity. (biomedsearch.com)
in particular, tyramine, serotonin, L-norepinephrine, (-)-epinephrine and dopamine owing to their (poly)phenolic structure too, while aliphatic polyamines-spermine, spermidine, putrescine and cadaverine - histamine, melatonin and tryptamine appear to act specifically on the oxygen-consuming species involved in the lipid peroxidation of polyunsaturated fatty acids. (scirp.org)
Spermidine is a polyamine formed from putrescine. (drugbank.ca)
Histamine and other polyamines such as Putrescine, Cadaverine, Spermidine and Spermine are products of decomposition. (environmental-expert.com)
The anti-senescence biogenic polyamines (PAs) putrescine (Put), spermidine (Spd) and spermine (Spm) are involved in plant growth processes and responses to stress. (ac.ir)
Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. (hornweed.info)
The polyamines are spermine, spermidine, and putrescine. (kieranmacphail.com)
Biogenic amines putrescine, spermidine and spermine are ubiquitous in nature and have interested researchers because they are essential for cell division and viability, and due to a large body of their pharmacological effects on growth and development in most living cells. (ox.ac.uk)

Spermine is a polyamine. (rcsb.org)
Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. (rcsb.org)
I. G. Sava, V. Battaglia, C. A. Rossi, M. Salvi and A. Toninello, "Free Radical Scavenging Action of the Natural Polyamine Spermine in Rat Liver Mitochondria," Free Radicals Biology & Medicine, Vol. 41, No. 8, 2006, pp. 1272-1281. (scirp.org)
The present work describes the development and optimization of electrochemical biosensors for specific determination of the biogenic polyamine spermine (Spm) and spermidine. (naver.com)
Spermidine/spermine-N1-acetyltransferase (SSAT) is a highly inducible and tightly controlled enzyme that is the rate-limiting step for polyamine catabolism. (qscience.com)
Polyamine concentration is solutions of spermine and spermidine as well as in lyophilisate of MCF-7 cells was measured by luminescence of the samples excited by laser beam at 380 nm. (exp-oncology.com.ua)

Some prominent examples of biogenic monoamines include: Monoamine neurotransmitters Imidazoleamines Histamine - a substance derived from the amino acid histidine that acts as a neurotransmitter mediating arousal and attention, as well as a pro-inflammatory signal released from mast cells in response to allergic reactions or tissue damage. (wikipedia.org)
Even though there are no legal limits for the concentration of biogenic amines in wines, some European countries only recommend maximum limits for histamine. (wikipedia.org)
There are several toxicological effects of biogenic amines on humans, especially histamine. (biomedsearch.com)
Histamine is the most pleiotropic biogenic amine. (uma.es)
Histamine (Hia) is the most multifunctional biogenic amine. (uma.es)
Biogenic amines in foods: histamine and food processing. (utb.cz)
In recent years, there has been a great interest in biogenic amines such histamine, as they are associated with the quality and safety of some kinds of fermented foods. (sciendo.com)
17. Kim S.H., Gigry B., Barros B., Price R.G.: Histamine and biogenic amines production by M. morganii isolated form temperature abused albacore. (sciendo.com)

Cytotoxic effects of metal complexes of biogenic polyamines. (uc.pt)

18. Komprda T., Smělá D., Novická K., Kalhotka L., Šustová K., Pechová P.: Content and distribution of biogenic amines in Dutch-type hard cheese. (sciendo.com)

Low-Capacity Cation-Exchange Column for Gradient Profiling and Amine Determination The Thermo Scientific Dionex IonPac* CS17 carboxylate-functionalized cation-exchange column is tailored for gradient separation of polyvalent and moderately hydrophobic amines, including biogenic amines and diamines, using simple aqueous eluents and elevated temperature (40 °C). The Dionex IonPac CS17 is an excellent column for use with Reagent-Free* IC systems using eluent generation, which requires only a deion. (selectscience.net)
The Thermo Scientific Dionex IonPac* CS17 carboxylate-functionalized cation-exchange column is tailored for gradient separation of polyvalent and moderately hydrophobic amines, including biogenic amines and diamines, using simple aqueous eluents and elevated temperature (40 °C). The Dionex IonPac CS17 is an excellent column for use with Reagent-Free* IC systems using eluent generation, which requires only a deionized water source to produce methanesulfonic acid eluent. (selectscience.net)
2000. Combined ion-pair extraction and gas chromatography - mass spectrometry for the simultaneous determination of diamines, polyamines and aromatic amines in Port wine and grape juice. (koreascience.or.kr)
Polar amines (alkanolamines and methylamines) and moderately hydrophobic amines (biogenic amines, diamines and polyamines) in diverse sample matrices, including foods and beverages. (thermofisher.com)
Gradient separation of polyvalent and more hydrophobic amines, biogenic amines, and diamines. (thermofisher.com)

It can also be used for separation of moderately hydrophobic amines, including biogenic amines, alkyldiamines, and polyamines. (selectscience.net)

The addition of preservatives to foods influences the microbial population dynamics and, consequently, the production of biogenic amines. (asmscience.org)

A combined model of hepatic polyamine and sulfur amino acid metabolism to analyze S-adenosyl methionine availability. (uma.es)
Several studies show that cancer cell proliferation is dependent on polyamine levels and that there are higher concentrations in cancer cells compared to normal cells, or that there are relationships between polyamine metabolism and cancers. (viralmuffin.com)

Lozanov, V., Petrov, S., Mitev, V. (2004) Simultaneous analysis of amino acid and biogenic polyamines by high-performance liquid chromatography after pre-column derivatization with N-(9-fluorenylmethoxycarbonyloxy) succinimide. (springer.com)
9. Durlu-Özkaya F., Ayhal K., Özkan G.: Biogenic amines determination in Tulum cheese by high performance liquid chromatography (HPLC). (sciendo.com)

This review covers some common aspects of the biosynthesis, interconversion pathways and biochemical functions of polyamines. (bvsalud.org)
DFMO is an irreversible inhibitor of ornithine decarboxilase (ODC), the key enzyme in mammalian polyamine biosynthesis, and has been shown to induce apoptosis. (bvsalud.org)

1993. Liquid chromatographic determination of biogenic amines in dry sausages. (koreascience.or.kr)
2001. Determination of biogenic amines in fresh unpacked and vacuum-packed beef during storage at 4 $^{\circ}$ C. Food Chem. (koreascience.or.kr)
Determination of biogenic amines in foods using ultra-performance liquid chromatography (UPLC). (utb.cz)

1994. Biogenic amines and their production by microorganisms in food. (koreascience.or.kr)
In fermented foods, one can expect the presence of many kinds of microorganisms, some of them being capable of producing biogenic amines. (wikipedia.org)
The problem of biogenic amines in fermented foods and the use of potential biogenic amine-degrading microorganisms as a solution. (utb.cz)
2012. Selection of biogenic amine-reducing microorganisms from a traditional Korean-style fermented food, Cheonggukjang. (koreascience.or.kr)
Biogenic amine formation and degradation by potential fish silage starter microorganisms. (koreascience.or.kr)
Biogenic amine concentrations in meat are associated with the proliferation of contaminating microorganisms. (maso-international.cz)

In our complexes, the Pt(II) or Pd(II) ion is not bound to ammonia as in cisplatin but it is bound to NH 2 and NH groups of linear polyamines. (stfc.ac.uk)
Vibrational spectroscopy [both Raman and INS (inelastic neutron scattering)], coupled to quantum mechanical calculations, was used in order to perform a thorough structural analysis of linear polyamines and polynuclear polyamine metal chelates [e.g. with Pt(II) and Pd(II)] with potential anticancer activity. (portlandpress.com)

Some lactic acid bacteria isolated from commercial bottled yoghurt have been shown to produce biogenic amines. (wikipedia.org)
DB1022 were found to be able to produce biogenic amines. (koreascience.or.kr)

Technological factors affecting biogenic amine content in foods: A review. (koreascience.or.kr)

The same visual stimulation protocol also induces a polyamine synthesis-dependent reduction in Ca2+-permeable AMPAR-mediated synaptic drive, suggesting that the increased excitability may compensate for this reduction. (ox.ac.uk)
Accordingly, the change in excitability was prevented by blocking polyamine synthesis during visual stimulation and was rescued when Ca2+-permeable AMPAR-mediated transmission was selectively reduced. (ox.ac.uk)
Deregulation of the level of polyamines and enzymes of their synthesis is often associated with pathological conditions, in particular, tumor growth, and their level in urine and plasma can be used as a diagnostic indicator of cancer. (exp-oncology.com.ua)
By allowing in particular to initiate the synthesis of DNA and proteins, polyamines are thus closely related to the growth processes of cells, including cancer cells. (viralmuffin.com)
Alterations in synaptic transmission are implicated in brain dysfunction in PKU, and several experimental data suggest that the principal cause for this dysfunction is the impairment in biogenic amine synthesis (5). (thefreedictionary.com)
Inhibition of polyamine uptake potentiates the anti-proliferative effect of polyamine synthesis inhibition and preserves the contractile phenotype of vascular smooth muscle cells. (lu.se)

Changes in the concentrations of biogenic amines (BAs) in fresh beef, pork, and chicken breast and leg were investigated during storage, and the relationship between the content of volatile basic nitrogen (VBN) and BAs was evaluated. (koreascience.or.kr)
A higher level of luminescence intensity of nanoparticles was found during analysis the polyamines in MCF-7 lyophilisate allowing for detecting polyamines at concentrations from 100 cells/ml to 100,000 cells/ml. (exp-oncology.com.ua)

We show that the inability to import ammonia via the Amt gas channel or to synthesize polyamines prevent modification in the resistance profile of aerially exposed bacteria. (wiley.com)

We have shown that the ability to enhance SSAT activity is a useful tool for cancer research, perhaps especially so for prostate cancer since the polyamine pathway is particularly active in this organ. (qscience.com)

1. The effect of natural polyamines on KATP channels was studied using inside-out patches from guinea-pig ventricular myocytes. (meta.org)
6. Our results indicate that natural polyamines influence native KATP channel gating in cardiac myocytes. (meta.org)

Under this context, we provide an overview over the most widely employed analytical techniques for biogenic amines determination such as chromatographic techniques and biosensors, emphasizing on new approaches. (intechopen.com)

Studies of aging and of the molecular effects of polyamines in general and spermidine in particular are used to synthesize our knowledge on what molecular mechanisms spermidine and other polyamines trigger to positively affect aging. (nih.gov)
Biogenic amines are organic bases with low molecular weight and are synthesized by microbial, vegetable and animal metabolisms. (wikipedia.org)
Biogenic amines are low-molecular-mass substances, essential for proper health for all organisms. (intechopen.com)
Biogenic amines (BAs) are small molecular organic nitrogenous compounds (bases), polar or semipolar. (intechopen.com)
Polyamines are low molecular weight molecules that cause strong electrostatic interaction with other molecules. (viralmuffin.com)
Polyamines are molecules of low molecular weight, consisting of a carbon chain having at least two amino groups positively charged at physiological pH. (viralmuffin.com)
In recent years, molecular aspects of polyamine action have also begun to emerge. (ox.ac.uk)

ROS are produced in various cellular processes and organelles: electron leakage from the mitochondrial electron transport chain (ETC), degradation of lipids, amino acids, and biogenic polyamines, protein folding in the lumen of endoplasmic reticulum (ER), and so forth [ 3 - 7 ]. (hindawi.com)
This chapter discusses the formation and degradation of biogenic amines, their occurrence in foods, their significance in food safety, their potential use as quality indicators, and the available methods for their determination. (asmscience.org)
Biogenic Amine Degradation by Bacillus Species Isolated from Traditional Fermented Soybean Food and Detection of Decarboxylase- Related Genes. (utb.cz)

13. El-Zahar K.M., El-Zaher A.M.A., Ramadan M.F.: Levels of biogenic amines in cheeses and their impact on biochemical and histological parameters in rats. (sciendo.com)

However, food containing high amounts of biogenic amines may have toxicological effects. (wikipedia.org)

Mastilović, J. (2015) The optimisation of traditional fermentation process of white cabbage (in relation to biogenic amines and polyamines content and microbiological profile). (ceon.rs)
12. El-Zahar K.M.: Biogenic amines and microbiological profile of Egyptian cheeses. (sciendo.com)

Biogenic amines are amino acid-derived compounds involved in the most important physiological functions: cell proliferation and differentiation, immunity, neurotransmission and neuroendocrine system, fertility. (uma.es)

Polyamines act as ROS scavengers, however, their catabolism is accompanied by H 2 O 2 production. (mdpi.com)
Using Escherichia coli K12 as a model organism, and increased resistance to tetracycline as the phenotypic read-out, we demonstrate that exposure to ammonia generated by the catabolism of l -aspartate increases the level of intracellular polyamines, in turn leading to modifications in membrane permeability to different antibiotics as well as increased resistance to oxidative stress. (wiley.com)

Moderately low-capacity cation-exchange column for analysis of aliphatic amines, aromatic amines, and polyamines using MSA or sulfuric acid eluents. (thermofisher.com)

Inhibition of Polyamine Formation Antagonizes Vascular Smooth Muscle Cell Proliferation and Preserves the Contractile Phenotype. (lu.se)

Several polynuclear Pt(II) chelates with biogenic polyamines were synthesized and screened for their potential antiproliferative and cytotoxic activity in different human cancer cell lines. (uc.pt)

Here we review the recent CD spectroscopic studies of the induction of DNA conformational changes by different ligands, which includes metal derivative complex of aureolic family drugs, actinomycin D, neomycin, cisplatin, and polyamine. (mdpi.com)

1997. Biogenic amine and polyamine contents in meat and meat products. (koreascience.or.kr)

2002) Biogenic amine formation in bottled beer. (aimspress.com)
Therefore, changes to soil environment caused by agricultural management can affect SOM production, thereby modifying the route for biogenic and physicogenic aggregate formation (Pulleman 2002). (thefreedictionary.com)

Biogenic polyamines that are toxic to humans can be measured in distilled drinks using a direct mass spectrometric method after trapping them in inclusion complexes. (spectroscopynow.com)
Ingestion of a large quantity of biogenic amines in food may produce negative toxic symptoms in humans. (maso-international.cz)

Biogenic Amines in Foods, p 248-274. (asmscience.org)
This study was performed to examine the levels of biogenic amines (BAs) in foods of animal origin such as egg, ham, sausage, milk, cheese and yoghurt distributed on Korean domestic markets, and to compare the results with those of western countries. (koreascience.or.kr)
Biogenic amines can be found in all foods containing proteins or free amino acids and are found in a wide range of food products including fish products, meat products, dairy products, wine, beer, vegetables, fruits, nuts and chocolate. (wikipedia.org)
In non-fermented foods the presence of biogenic amines is mostly undesired and can be used as indication for microbial spoilage. (wikipedia.org)
Finally, we focus on foods in which biogenic amines mainly occur such as fish, meat and wine and other fermented products. (intechopen.com)
Scientific opinion on risk based control of biogenic amine formation in fermented foods. (utb.cz)
In conclusion, the two probiotic Bacillus strains may be considered as the suitable starter for manufacture of fermented soybean foods with low biogenic amines content. (koreascience.or.kr)
2006. Evaluation of biogenic amines in Korean commercial fermented foods. (koreascience.or.kr)
3. Bodmer S., Imark C., Kneubuhl M.: Biogenic amines in foods. (sciendo.com)
15. Ercan S.S., Bozkurt H., Soysal C.: Significance of biogenic amines in foods and their reduction methods. (sciendo.com)
The use of such a diet may, however, raise questions because of the exclusion of certain foods normally considered to be beneficial to health, but this is a specific protocol, the possible benefits of which may justify its temporary application without questioning the long-term interests of foods that are rich in polyamines. (viralmuffin.com)

In this review, we focus on the roles of biogenic polyamines and oxidative protein folding in the endoplasmic reticulum (ER) and their interplay with viruses. (mdpi.com)
Biogenic amines in fish: roles in intoxication, spoilage, and nitrosamine formation. (koreascience.or.kr)
The roles of food in the prevention and support of certain pathologies are more and more highlighted, the example of polyamines is significant. (viralmuffin.com)
Differential and functional interactions emphasize the multiple roles of polyamines in plants. (ox.ac.uk)

Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties. (nih.gov)
Biogenic amines are naturally present in grapes or can occur during the vinification and aging processes, essentially due to the microorganism's activity. (wikipedia.org)

Cellular polyamines promote the aggregation of α-synuclein. (mpg.de)
Thus, transcriptome, limited protein profiling, and metabolome studies of transgenic tomato fruit have yielded significant new information on cellular processes impacted by polyamine manipulation. (ox.ac.uk)

1996. Biogenic amines in dry sausages as affected by starter culture and contaminant amine-positive lactobacillus. (koreascience.or.kr)
1996. Biogenic amine sources in cooked cured shoulder pork. (koreascience.or.kr)

R. Kaur-Sawhney, A. Altman and W. Galston, "Dual Mechanisms in Polyamine-Mediated Control of Ribonuclease Activity in Oat Leaf Protoplasts," Plant Physiology, Vol. 2, 1978, pp. 158-160. (scirp.org)

Besides their potential toxicity, biogenic amines are used for the evaluation of hygienic quality of different marine and freshwater species. (biomedsearch.com)

Condensing agents such as cobalt hexamine and biogenic polyamines such as spermidine, also crowding agents such as polyethylene glycol can be used to effectively increases the concentration of enzymes. (mybiosource.com)
The minimum concentration for the detection of polyamines in model solutions is 10 ng/ml, and maximum one is 100 ng/ml. (exp-oncology.com.ua)

2001. Biogenic amines produced by Enterobacteriaceae isolated from meat products. (koreascience.or.kr)

Biogenic polyamines promote the aggregation of α‐synuclein and may constitute endogenous agents modulating the pathogenesis of PD. (embopress.org)

Given that polyamines can interact with many molecules, it is not surprising that they affect aging via several mechanisms. (nih.gov)
Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA. (bvsalud.org)
SSAT can be induced by small molecules, including the biogenic polyamines themselves, which activate the negative feedback mechanism used to remove excess levels of these polyamines. (qscience.com)

Biogenic amines in processed cheese available in Egypt. (utb.cz)

Polyamines are involved in intracellular signals. (rainbow.coop)
Polyamine potentiation and inhibition of NMDA-mediated increases of intracellular free Ca2+ in cultured chick cortical neurons. (harvard.edu)

IJMS | Free Full-Text | Polyamine Metabolism and Oxidative Protein Folding in the ER as ROS-Producing Systems Neglected in... (mdpi.com)

Catalytic effects of Murchison Material: Prebiotic Synthesis and Degradation of RNA Precursors | SpringerLink (link.springer.com)

Men worse for climate change than women (so if enough transition, will that stop the floods?) « JoNova (joannenova.com.au)

Frontiers | Role of Starter Cultures on the Safety of Fermented Meat Products | Microbiology (frontiersin.org)

ODC1 | Cancer Genetics Web (cancerindex.org)

Publications | Max Planck Institute for Biophysical Chemistry (mpibpc.mpg.de)

ASMscience | Biogenic Amines in Foods (asmscience.org)

Thermo Scientific™ IonPac® CS17 Cation-Exchange Column from Thermo Fisher Scientific | SelectScience (selectscience.net)

NMR of α‐synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation | The EMBO Journal (emboj.embopress.org)

Johné Liu - Xenbase Personal Page (xenbase.org)

Effect of Foliar Feeding on Nitrogen Assimilation in Alfalfa Plants at Insufficient Molybdenum Supply | SpringerLink (rd.springer.com)

Two sides of the same coin? Unraveling subtle differences between human embryonic and induced pluripotent stem cells by Raman... (stemcellres.biomedcentral.com)

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The effect of polyamines on KATP channels in guinea-pig ventricular myocytes | Meta (meta.org)

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Fundamentals of Sour Beer Fermentation - Sour Beer Blog (sourbeerblog.com)

Frontiers | Effect of Natural Zeolite (Clinoptilolite) on in vitro Biogenic Amine Production by Gram Positive and Gram Negative... (frontiersin.org)

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Anatomy1

Organisms7

Diseases3

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes6

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Information Science1

Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. (1/216)

Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1. (2/216)

Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells. (3/216)

Influence of polyamines on DNA binding of heat shock and activator protein 1 transcription factors induced by heat shock. (4/216)

Inhibition of polyamine synthesis arrests trichomonad growth and induces destruction of hydrogenosomes. (5/216)

Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport. (6/216)

The non-enzymatic hydrolysis of oligoribonucleotides VI. The role of biogenic polyamines. (7/216)

Polyamine regulation of plasma membrane phospholipid flip-flop during apoptosis. (8/216)

Biogenic Polyamines

Polyamines

Spermine

Putrescine

Spermidine

Biogenic Amines

Electrophoresis, Capillary

Spectroscopy, Fourier Transform Infrared

Receptors, Biogenic Amine

Ornithine Decarboxylase

Eflornithine

Octopamine

Cadaverine

Adenosylmethionine Decarboxylase

Diamines

Biogenic Monoamines

Ornithine

Tyramine

Camellia sinensis

Camellia

Tea

Amines

Catechin

Dictyostelium

Ammonia

Bacteria

Molecular Sequence Data

Anti-Bacterial Agents

Drug Resistance, Bacterial

Circular Dichroism

Nucleic Acid Conformation

DNA

Protein Conformation

Models, Molecular

G-Quadruplexes

Oxidative Stress

HIV-1

Reactive Oxygen Species

HIV Infections

Anti-HIV Agents

Antiretroviral Therapy, Highly Active

Polylysine

Scopolamine Hydrobromide

Ethylamines

Kidney Papillary Necrosis

Amino Acids

Glutamine

Carboxymethylcellulose Sodium

Starlings

Gingival Neoplasms

Mites

Goblet Cells

Ki-67 Antigen

Genes, myc

Nuclear Proteins

Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. (1/216)

Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1. (2/216)

Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells. (3/216)

Influence of polyamines on DNA binding of heat shock and activator protein 1 transcription factors induced by heat shock. (4/216)

Inhibition of polyamine synthesis arrests trichomonad growth and induces destruction of hydrogenosomes. (5/216)

Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport. (6/216)

The non-enzymatic hydrolysis of oligoribonucleotides VI. The role of biogenic polyamines. (7/216)

Polyamine regulation of plasma membrane phospholipid flip-flop during apoptosis. (8/216)

Glycosylated polyamines - Patent # 6420344 - PatentGenius

Polyamines containing acid groups that are useful in papermaking - Patent # 4166002 - PatentGenius

OAZ1 Gene - GeneCards | OAZ1 Protein | OAZ1 Antibody

Difference between revisions of Alcazar:Publications - OpenWetWare

Functional interaction between GCN5 and polyamines: a new role for core histone acetylation | The EMBO Journal

Plus it

Rabbit Polyclonal to CSFR - Breast Cancer-derived Factors Stimulate Osteoclastogenesis

Hexamine Factory Price Wholesale, Hexamine Suppliers - Alibaba

Hexamine | Article about Hexamine by The Free Dictionary

JPH10204040A - Alicyclic polyamine and its production - Google Patents

A stable isotope labelling assisted LC-MS method for the determination of polyamines in micro-tissues of rice - Analytical...

Cyclic Polyamines | Organic Chemicals | Spectrum Chemical

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Polyamines are involved in the regulation of S phase and DNA synthesis

From Embryo to Old Age Cologne: RoshiniBR

Sci. Pharm. | Free Full-Text | Simultaneous Determination of Different Polyamines and their Mono-Acetylated Derivatives in...

Brain Neurons Express Ornithine Decarboxylase-Activating Antizyme Inhibitor 2 with Accumulation in Alzheimers Disease -...