A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.
An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
A polymeric mixture of polyesters of phosphoric acid and phloretin. It blocks some cellular responses to prostaglandins.
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
Integral membrane proteins of the LIPID BILAYER of SECRETORY VESICLES that catalyze transport and storage of biogenic amine NEUROTRANSMITTERS such as ACETYLCHOLINE; SEROTONIN; MELATONIN; HISTAMINE; and CATECHOLAMINES. The transporters exchange vesicular protons for cytoplasmic neurotransmitters.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.
An order of gram-positive bacteria in the class Bacilli, that have the ability to ferment sugars to lactic acid. They are widespread in nature and commonly used to produce fermented foods.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
A pyridoxal-phosphate protein that catalyzes the conversion of L-tyrosine to tyramine and carbon dioxide. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine. (From Enzyme Nomenclature, 1992) EC 4.1.1.25.
A hybrid separation technique combining both chromatographic and electrophoretic separation principles. While the method was invented to separate neutral species, it can also be applied to charged molecules such as small peptides.
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A histamine H2 receptor antagonist that is used as an anti-ulcer agent.
A dithiobiurea compound with anti-gonadotropic activity.
Biogenic amines having more than one amine group. These are long-chain aliphatic compounds that contain multiple amino and/or imino groups. Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA.
Tetrahydroisoquinolinol alkaloids in both dextro and levo forms, originally found in SALSOLA plants.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.
Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.
A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
A species of gram-positive, rod-shaped LACTIC ACID bacteria that is frequently used as starter culture in SILAGE fermentation, sourdough, and lactic-acid-fermented types of beer and wine.
Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
The removal of a carboxyl group, usually in the form of carbon dioxide, from a chemical compound.
A genus in the subfamily CALLITRICHINAE consisting of 12 species and found in Panama as well as South America. Species seen most frequently in the literature are S. oedipus (cotton-top marmoset), S. nigricollis, and S. fusicollis.
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.
Procedures or techniques used to keep food from spoiling.
One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.
A nutritious food consisting primarily of the curd or the semisolid substance formed when milk coagulates.
Slender tubular or hairlike excretory structures found in insects. They emerge from the alimentary canal between the mesenteron (midgut) and the proctodeum (hindgut).
A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
A class of sodium-independent nucleoside transporters that mediate the facilitative transport of NUCLEOSIDES.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

Agonistic behaviour and biogenic amines in shore crabs Carcinus maenas. (1/250)

To investigate the role of certain neurohormones in agonistic behaviour, fights were staged between pairs of size-matched male shore crabs Carcinus maenas, and blood samples were taken immediately after the contests had been resolved. Samples were also taken from these crabs at rest (before and after fighting) and after walking on a treadmill. A control group of crabs also had samples taken on each experimental day. Concentrations of tyramine, dopamine, octopamine, serotonin (5-HT) and norepinephrine were determined in each blood sample using a gas chromatography/mass spectrometry (GC-MS) system. Norepinephrine was not detectable in any of the samples, but the standards were recovered. Tyramine values were not significantly different between the control group and the fought group, so tyramine does not appear to be important in agonistic behaviour. A comparison between the control and fought groups shows that fighting had an effect on the concentrations of octopamine, dopamine and 5-HT, but exercise only had an effect on octopamine levels, which showed a reduction from resting values in both winners and losers. Resting and post-fight concentrations of octopamine, dopamine and 5-HT were higher in winners than in losers. 5-HT concentration increased in the blood of fought crabs from resting values, whereas dopamine concentration decreased. In winners, octopamine concentrations decreased from resting values, but in losers octopamine levels increased from resting concentrations. The escalatory behaviour or intensity of fighting performed by winners and losers was related to dopamine levels but not to those of octopamine or 5-HT. Therefore, there appears to be a link between relative concentrations of these three amines (dopamine, octopamine and 5-HT) and fighting ability; the effects are not simply a result of activity. The better competitors have higher concentrations of these three amines at rest and after fighting.  (+info)

Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex. (2/250)

5-Hydroxytryptamine (5-HT) plays a role in the regulation of 3, 4-dihydroxyphenylethylamine (dopamine) neurons in the brain, but the precise mechanism of regulation by 5-HT(1A) receptors of dopamine release has not been defined. The present study describes the effect of 5- inverted question mark3-[[(2S)-1,4-benzodioxan-2ylmethyl]amino]propoxy inverted question mark-1, 3-benzodioxole HCl (MKC-242), a highly potent and selective 5-HT(1A) receptor agonist, on dopamine release in the prefrontal cortex using microdialysis in the freely moving rat. Subcutaneous injection of MKC-242 (0.3 - 1.0 mg kg(-1)) increased extracellular levels of dopamine in the prefrontal cortex. The effect of MKC-242 in the prefrontal cortex was antagonized by pretreatment with the selective 5-HT(1A) receptor antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohe xanecarboxamide (WAY100635; 1 mg kg(-1), i.p.). Local application of WAY100635 (10 microM) via a microdialysis probe antagonized the effect of systemic MKC-242 in an increasing dopamine release, and locally infused 8-hydroxy-2-(di-n-propylamino)tetralin (10 microM) increased dopamine release in the prefrontal cortex. MKC-242 increased cortical dopamine release in the rats pretreated with 5, 7-dihydroxytryptamine (150 microgram, i.c.v.) that caused an almost complete reduction in cortical 5-HT content. The effect of MKC-242 to increase dopamine release was also observed in the hippocampus, but not in the striatum or nucleus accumbens. Fluoxetine, a selective serotonin reuptake inhibitor, increased dopamine release in the prefrontal cortex, but not in the nucleus accumbens, while buspirone, a 5-HT(1A) receptor agonist, increased dopamine release in both brain regions. The present results indicate that activation of postsynaptic 5-HT(1A) receptors increases dopamine release in a brain region-specific manner.  (+info)

Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. (3/250)

Presynaptic transporter proteins regulate the clearance of extracellular biogenic amines after release and are important targets for multiple psychoactive agents, including amphetamines, cocaine, and antidepressant drugs. Recent studies reveal that dopamine (DA), norepinephrine (NE), and serotonin (5-HT) transporters (DAT, NET, and SERT, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase C (PKC). With SERTs, PKC activation results in activity-dependent transporter phosphorylation and sequestration. Protein phosphatase 1/2A (PP1/PP2A) inhibitors, such as okadaic acid (OA) and calyculin A, also promote SERT phosphorylation and functional downregulation. How kinase, phosphatase, and transporter activities are linked mechanistically is unclear. In the present study, we found that okadaic acid-sensitive phosphatase activity is enriched in SERT immunoprecipitates from human SERT stably transfected cells. Moreover, blots of these immunoprecipitates reveal the presence of PP2A catalytic subunit (PP2Ac), findings replicated using brain preparations. Whole-cell treatments with okadaic acid or calyculin A diminished SERT/PP2Ac associations. Phorbol esters, which trigger SERT phosphorylation, also diminish SERT/PP2Ac associations, effects that can be blocked by PKC antagonists as well as the SERT substrate 5-HT. Similar transporter/PP2Ac complexes were also observed in coimmunoprecipitation studies with NETs and DATs. Our findings provide evidence for the existence of regulated heteromeric assemblies involving biogenic amine transporters and PP2A and suggest that the dynamic stability of these complexes may govern transporter phosphorylation and sequestration.  (+info)

Neurochemical and metabolic aspects of antidepressants: an overview. (4/250)

Antidepressants, in addition to being effective therapeutic agents for depression, have also proved to be multifaceted drugs useful for treating a number of other psychiatric and neurologic disorders. Despite the widespread use of these drugs, much remains to be understood about their mechanisms of action and other important aspects, such as their metabolism and potential interactions with other drugs. This article reviews research conducted in the authors' laboratories on various aspects of antidepressants, including trace amines and antidepressants, gamma-aminobutyric acid and antidepressants, drug metabolism, development and application of rapid, sensitive assay procedures for antidepressants and their metabolites; and drug development based on analogues of the antidepressants phenelzine and tranylcypromine. The significance of this work to future drug development is also discussed.  (+info)

Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. (5/250)

Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two-step mechanism: Na(+)-K(+)-ATPase-energized basolateral active extrusion of sodium permits passive apical entry through various sodium transport systems. In the past 15 years, most of the renal sodium transport systems (Na(+)-K(+)-ATPase, channels, cotransporters, and exchangers) have been characterized at a molecular level. Coupled to the methods developed during the 1965-1985 decades to circumvent kidney heterogeneity and analyze sodium transport at the level of single nephron segments, cloning of the transporters allowed us to move our understanding of hormone regulation of sodium transport from a cellular to a molecular level. The main purpose of this review is to analyze how molecular events at the transporter level account for the physiological changes in tubular handling of sodium promoted by hormones. In recent years, it also became obvious that intracellular signaling pathways interacted with each other, leading to synergisms or antagonisms. A second aim of this review is therefore to analyze the integrated network of signaling pathways underlying hormone action. Given the central role of Na(+)-K(+)-ATPase in sodium reabsorption, the first part of this review focuses on its structural and functional properties, with a special mention of the specificity of Na(+)-K(+)-ATPase expressed in renal tubule. In a second part, the general mechanisms of hormone signaling are briefly introduced before a more detailed discussion of the nephron segment-specific expression of hormone receptors and signaling pathways. The three following parts integrate the molecular and physiological aspects of the hormonal regulation of sodium transport processes in three nephron segments: the proximal tubule, the thick ascending limb of Henle's loop, and the collecting duct.  (+info)

A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake. (6/250)

A human midgut carcinoid tumor was successfully transplanted into nude mice and propagated for five consecutive generations (30 months) with well-preserved phenotype. Tumor cells in nude mice expressed identical neuroendocrine markers as the original tumor, including somatostatin receptors (somatostatin receptors 1 to 5) and vesicular monoamine transporters (VMAT1 and VMAT2). Because of the expression of somatostatin receptors and VMAT1 and VMAT2 the grafted tumors could be visualized scintigraphically using the somatostatin analogue 111In-octreotide and the catecholamine analogue 123I-metaiodobenzylguanidine. The biokinetics of the somatostatin analogue 111In-octreotide in the tumors was studied and showed a high retention 7 days after administration. Cell cultures were re-established from transplanted tumors. Immunocytochemical and ultrastructural studies confirmed the neuroendocrine differentiation. The human origin of transplanted tumor cells was confirmed by cytogenetic and fluorescence it situ hybridization analyses. Spontaneous secretion of serotonin and its metabolite, 5-hydroxyindole acetic acid, from tumor cells was demonstrated. The tumor cells increased their [Ca2+]i in response to beta-adrenoceptor stimulation (isoproterenol) and K+-depolarization. All somatostatin receptor subtypes could be demonstrated in cultured cells. This human transplantable carcinoid tumor, designated GOT1, grafted to nude mice, will give unique possibilities for studies of somatostatin receptor- and VMAT-mediated radionuclide uptake as well as for studies of secretory mechanisms.  (+info)

Biogenic amines in Drosophila virilis under stress conditions. (7/250)

The effect of heat stress (38 degrees C) on the content of DL-beta-(3,4-dihydroxyphenyl)alanine (DOPA), dopamine, tyramine, octopamine, and their precursor Tyr was studied in adults of two lines of Drosophila virilis contrasting in their stress response. In individuals of line 101 responding to stress by a hormonal stress reaction, the contents of DOPA, dopamine, octopamine, and Tyr were lower than those of line 147 that did not respond to the stress. However, heat stress caused an increase in the contents of DOPA, dopamine, octopamine, and Tyr in line 101, whereas the equivalent titers in line 147 remain unchanged.  (+info)

Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [3H]imipramine reuptake in the primary fibromyalgia syndrome. (8/250)

BACKGROUND: Primary fibromyalgia syndrome (PFS) is a chronic disorder commonly seen in rheumatological practice. The pathophysiological disturbances of this syndrome, which was defined by the American College of Rheumatology in 1990, are poorly understood. This study evaluated, in 30 patients, the hypothesis that PFS is a pain modulation disorder induced by deregulation of serotonin metabolism. OBJECTIVES: To compare platelet [(3)H]imipramine binding sites and serotonin (5-HT) levels in plasma-rich platelets (PRP) of PFS patients with those of matched healthy controls and to compare the levels of biogenic amine metabolites in the cerebrospinal fluid (CSF) of PFS patients with those of matched controls. METHODS: Platelet [(3)H]imipramine binding sites were defined by two criteria, B(max) for their density and K(d) for their affinity. PRP 5-HT and CSF metabolites of 5-HT (5-hydroxyindoleacetic acid, 5-HIAA), norepinephrine (3-methoxy, 4-hydroxy phenylglycol, MHPG) and dopamine (homovanillic acid, HVA) were assayed by reversed-phase high-performance liquid chromatography with coulometric detection. RESULTS: [(3)H]Imipramine platelet binding was similar (P=0.43 for B(max) and P=0.30 for K(d)) in PFS patients (B(max)=901+/-83 fmol/mg protein, K(d)=0.682+/-0.046) and in matched controls (B(max)=1017+/-119 fmol/mg protein, K(d)=0.606+/-0.056). PRP 5-HT was significantly higher (P=0.0009) in PFS patients (955+/-101 ng/10(9) platelets) than in controls (633+/-50 ng/10(9) platelets). When adjusted for age, the levels of all CSF metabolites were lower in PFS patients. The CSF metabolite of norepinephrine (MHPG) was lower (P:=0.003) in PFS patients (8.33+/-0.33 ng/ml) than in matched controls (9.89+/-0.31 ng/ml) and 5-HIAA was lower (P=0.042) in PFS female patients (22.34+/-1.78 ng/ml) than in matched controls (25.75+/-1.75 ng/ml). For HVA in females, the difference between PFS patients (36.32+/-3.20 ng/ml) and matched controls (38.32+/-2.90 ng/ml) approached statistical significance (P=0.054). CONCLUSION: Changes in metabolites of CSF biogenic amines appear to be partially correlated to age but remained diagnosis-dependent. High levels of PRP 5-HT in PFS patients were associated with low CSF 5-HIAA levels in female patients but were not accompanied by any change in serotonergic uptake as assessed by platelet [(3)H]imipramine binding sites. These findings do not allow us to confirm that serotonin metabolism is deregulated in PFS patients.  (+info)

TY - JOUR. T1 - Brain Biogenic Amine Depletion and Mood. AU - Mendels, Joseph. AU - Frazer, Alan. PY - 1974/4. Y1 - 1974/4. N2 - To evaluate the hypothesis that clinical depression is associated with reduced brain biogenic amine activity, the behavioral effects, in man, of drugs that deplete the brain of biogenic amines were reviewed. The behavioral changes associated with reserpine administration were interpreted as being primarily a psychomotor retardation-sedation syndrome, due perhaps to a dopamine deficiency, and would not be an adequate model for clinical depression. In susceptible persons, particularly those with a prior history of depression, this psychomotor retardation-sedation might be sufficient to trigger a depression-like episode. More selective amine depletion, produced either by alpha-methyl-paratyrosine or by parachlorophenylalanine is not associated with depression. Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that ...
TY - JOUR. T1 - Brain biogenic amine levels after methanol administration. T2 - Possible mechanism of action of central monoaminergic neurons in discrete areas of brain in Wistar rats. AU - Jeganathan, P. S.. AU - Namasivayam, A.. PY - 1989/1/1. Y1 - 1989/1/1. UR - http://www.scopus.com/inward/record.url?scp=0024396801&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024396801&partnerID=8YFLogxK. M3 - Article. C2 - 2592039. AN - SCOPUS:0024396801. VL - 33. SP - 151. EP - 156. JO - Indian Journal of Physiology and Pharmacology. JF - Indian Journal of Physiology and Pharmacology. SN - 0019-5499. IS - 3. ER - ...
en fr Study of biogenic amines metabolism in wine lactic acid bacteria Etude du métabolisme des amines biogènes chez les bactéries lactiques du vin . . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Spoilage Detection with Biogenic Amine Biosensors, Comparison of Different Enzyme Electrodes. AU - Bóka, Beáta. AU - Adányi, N.. AU - Virág, Diána. AU - Sebela, Marek. AU - Kiss, Attila. PY - 2012/1. Y1 - 2012/1. N2 - Three enzyme based amperometric biosensors for biogenic amines were applied for meat spoilage monitoring. With diamine oxidase (EC 1.4.3.6), the total biogenic amine content was measured. Monoamine oxidase A (EC 1.4.3.4) was used for determination of tyramine, tryptamine and phenylethylamine content. Putrescine was selectively detected with putrescine oxidase (EC 1.4.3.10). The enzymes were separately co-immobilized on graphite electrodes with peroxidase and Os mediator (PVI7-dme-Os). A fast extraction method using special centrifugal separator was applied for pork and fish samples stored at different conditions. Although partial extraction was achieved, the results correlate with total biogenic amine content measured by HPLC method.. AB - Three enzyme based ...
Abstract (EN): The presence of biogenic amines in foodstuffs is an important food safety problem because of the implication of these compounds in food intolerance and intoxication. The separation and quantification of biogenic amines in foods is normally performed by chromatographic techniques. This review contains descriptions of the quantification of biogenic amines in Portuguese traditional fermented and/or ripened foods and wines, including Protected Denomination of Origin cheeses, drycured sausages, and Portuguese wines (including Port wines), using different analytical methods based on high-pressure liquid chromatography (UV or diode array and/or fluorometric detectors) and gas chromatography (with a mass spectrometry detector). The evolution of biogenic amines during fermentation, ripening, aging, or storage of those products was also evaluated. Biogenic amine concentrations ranged widely within individual food items, and storage, transport, and handling conditions can influence to some ...
Definition of biogenic amine hypothesis in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is biogenic amine hypothesis? Meaning of biogenic amine hypothesis as a legal term. What does biogenic amine hypothesis mean in law?
Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary ... read more tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean=0, SD=1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios ...
Fiore Sardo is a Protected Designation of Origin (PDO) cheese produced in Sardinia (Italy) from raw sheeps milk, presenting risk factors due to an accumulation of Biogenic Amines (BA). A total of 37 Fiore Sardo cheese samples produced in 19 dairy farms were collected from local retail stores to evaluate BA content and its relationship with free amino acids (FAA) and composition. The following were determined for each sample: pH, water activity, composition (moisture, dry matter, NaCl, protein and fat content). FAA and BA, after extraction, were determined by HPLC-FL. The total BA content in Fiore Sardo PDO cheese samples was 127±87 mg 100 g-1, ranging between 6 and 366 mg 100 g-1. Tyramine showed the highest concentration (82±51 mg 100 g-1), followed by putrescine (21±26 mg 100 g-1). Moreover, cadaverine, histamine, β-phenylethylamine and tryptamine were detected at concentrations lower than 10 mg 100 g-1. Overall 54% of the samples analysed exceeded the threshold of 90 mg 100 g-1 for total ...
In this study, the quantitative determination of eight biogenic amines (cadaverine, serotonin, histamine, spermidine, spermine, tyramine, putrescine and β-phenylethylamine) by an liquid chromatography method with evaporative light scattering detection was performed. The analysis of several samples of conventional, organic and fair trade cocoa-derivatives showed that organic and fair trade samples always contain much lower amine concentrations in comparison with their conventional counterparts, supporting the idea that biogenic amines can be regarded as cocoa quality markers. Irrespective of the kind of sample, results also showed that the most abundant amines were histamine, tyramine, spermidine, putrescine and spermine while β-phenylethylamine, cadaverine and serotonine have been found more rarely, all the amines never reaching dangerous amounts for consumer health. With the aim to confirm the experimental results, clustering analysis was performed on samples and instrumental results using principal
Free amino acids (FAAs) and biogenic amines were determined in whole hake (Merluccius merluccius L) stored in bulk under controlled or modified atmosphere (60% CO2:15% O2:25% N2) for 12 days at 2°C and followed by storage in trays either under the same special atmosphere or under air for 31 days at 2°C, which was the control. At the end of the storage, significant differences were observed (P≤0.05) in the amino acids isoleucine, leucine, methionine, phenylalanine, valine, glutamic acid and glycine between the control lot and the treated lots, and it was the control lot which exhibited the highest concentrations. However, the lots kept in special atmospheres exhibited higher levels of alanine, β-alanine, threonine, and tryptophan than the control lot. There was no relationship between the decreases in histidine, tyrosine, lysine, arginine and ornithine initial concentrations and the increases in their corresponding biogenic amine concentrations (histamine, tyramine, cadaverine, agmatine and ...
Biogenic amines (BAs) are organic amines present in meat, fish, dairy produce and wine due to the breakdown of amino acids, catalysed by microbial decarboxylases. BAs determination in food is important not only because of possible toxicological effects such as nausea, sweating and headache but also due to their possible role as indicators of food spoilage. Chromatographic methods are traditionally applied for determination of BAs in food [1], which usually require preliminary operations for sample pre-treatment that are laborious and difficult to automate. On the other hand, screening analytical systems provide simple, low cost and rapid analysis with the possibility of subjecting high number of samples to the screening system in a short time [2]. In this work we present a novel method for screening determination of BAs using a microfluidic system with the detection by highly sensitive thermal lens microscope (μFIA-TLM). Four biogenic amines (putrescine, cadaverine, histamine and tyramine) were ...
Autism spectrum disorders (ASD) constitute a complex, heterogeneous, multifactorial group of neurodevelopmental conditions characterized by impairment of social interactions, communication issues and repetitive behaviors. The heterogeneity of ASD is emerging as a dominant theme and poses a complex challenge in developing new treatments as well as biomarkers. Although there are umpteen biomarkers identified in relation to ASD, abnormalities in biogenic amines from the tryptophan metabolism pathway have been more commonly implicated in ASD. This review is a compilation of the reports on peripheral alterations of the biogenic amines of the tryptophan pathway in ASD. Based on the literature search of previous studies, whole blood serotonin may be considered as a diagnostic marker as well as a genetic vulnerability factor for this disease. The one-time after sleep offset measurement of plasma melatonin seems to be a sensitive, practical, feasible and convenient measurable parameter in the clinical ...
As noted in the Introduction, BAT ligands are classically divided into uptake inhibitors and releasers. Releasers are BAT substrates, and the inward transport of a BAT substrate, together with Na+ and Cl−, leads to the countertransport of endogenous neurotransmitter out of the nerve terminal. Resolution of the structure of the bacterial LeuTAa transporter (Yamashita et al., 2005; Shi et al., 2008) identified two substrate binding sites (S1 and S2), suggesting that the BATs might also possess two substrate binding sites, where the binding of a substrate to S2 triggers the release of substrate bound to S1 and Na+ into the intracellular compartment (Nyola et al., 2010; Schmitt et al., 2010). These findings emphasize the importance of conformational changes to transporter function (Ferrer and Javitch, 1998; Reith et al., 2001; Gether et al., 2006) and raise the possibility that the actions of the two BAT binding sites might differ. Data in the literature support this idea. For example, Goodwin et ...
Wines, specifically those in which lactic acid bacteria can grow can cause transient toxic effects due to the formation of biogenic amines such as histamine and tyramine. Some people specifically avoid red wines because they are more often associated with headaches and other discomforts. An understanding of the origin, occurrence and formation of amines in grape and berry wines will lead to developing approaches to preventing their formation ...
Objective: Isolation rearing of rats provides a non-pharmacological method of inducing behavioural changes in rodents that resemble schizophrenia or depression. Nevertheless, results are variable within different strains. We focused on neurochemical changes in several in vivo and post-mortem brain regions of Wistar (W) and Lister Hooded (LH) rats following post-weaning social separation.. Methods: Experiments were conducted after 6-8 weeks of isolation. For post-mortem studies, prefrontal cortex (PFC), nucleus accumbens (NAC), hippocampus (Hipp) and striatum (St) were collected by tissue dissection. In vivo experiments were conducted by microdialysis in the PFC. Analyses of dopamine (DA), serotonin (5-HT) levels and relative turnover were performed by using high-performance liquid chromatography.. Results: We found significant strain-related differences in biogenic amine content. LH rats were characterised by markedly raised DA, along with its turnover reduction, in all the post-mortem brain ...
TY - JOUR. T1 - Transformations of 3-acyl-4H-polyfluorochromen-4-ones under the action of amino acids and biogenic amines. AU - Shcherbakov, Konstantin V.. AU - Artemyeva, Mariya A.. AU - Burgart, Yanina V.. AU - Evstigneeva, Natalya P.. AU - Gerasimova, Natalya A.. AU - Zilberberg, Natalia V.. AU - Kungurov, Nicolai V.. AU - Saloutin, Victor I.. AU - Chupakhin, Oleg N.. PY - 2019/10/1. Y1 - 2019/10/1. KW - 3-acyl-4H-polyfluorochromen-4-ones. KW - Amines. KW - Antimycotic and antibacterial activity. KW - Deacylation. KW - Nucleophilic aromatic substitution. KW - Pyrone ring opening. KW - PRIVILEGED SCAFFOLD. KW - DRUG DISCOVERY. KW - FLAVONOIDS. KW - VISNAGIN. KW - PEPTIDES. KW - CHROMONES. KW - BIOLOGICAL EVALUATION. KW - FLUORINE. KW - AGENTS. KW - DERIVATIVES. UR - http://www.scopus.com/inward/record.url?scp=85070288939&partnerID=8YFLogxK. UR - ...
Twenty Apulian and Sicilian cheeses were analysed for their concentrations of eight biogenic amines (BAs), free amino acids, pH, water activity, and subjected to microbiological characterisation. In addition, lactic acid bacteria isolated from cheeses were assayed for their capacity to generate BAs. Principal component analysis was performed to find the effect of different parameters on the distribution of the cheeses. Although short-ripened (<= 30 d) cheeses did not show significant BA concentrations, the only BA showing high positive correlation with time of ripening was histamine. Concentration of histidine and, especially, percentage of histidine-decarboxylase bacteria presumably affected histamine concentration. High pH values were negatively correlated to the concentration of tyramine, putrescine, and cadaverine. Fifty percent of the cheeses contained at least one BA at potentially toxic concentrations. Unambiguous and ever-valid relations among parameters and BAs are difficult to ...
Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine. It has been sold online as a designer drug. It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively. Methamnetamine is illegal in Japan. Naphthylaminopropane HDEP-28 HDMP-28 Naphyrone WF-23 Richard B. Rothman; John S. Partilla; Michael H. Baumann; Catrissa Lightfoot-Siordia; Bruce E. Blough (April 2012). Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy Partial Substrates for the Biogenic Amine Transporters. The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251-262. doi:10.1124/jpet.111.188946. PMC 3364510 . PMID 22271821. Methamnetamine. WEDINOS. Methamnetamine. New Synthetic Drugs Database. ...
A large number of biogenic amines ELISA kits are available, these organic bases are formed by decarboxylation of amino acids or by transamination of aldehydes
biogenic amine: a biologically synthesized substance, fundamentally a nitrogen compound, widely dispersed in the body. Some hormones, such as adrenaline...
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Build confidence in your biogenic amine analysis by relying on the durability offered by Enzyme immunoassays (EIAs) and Radio immunoassays (RIAs).
Learn how bio-protection helps reducing wines final concentrations of biogenic amines and ochratoxin, which facilitates exports.
Biogenic amine은 주로 단백질을 함유한 식품이 미생물 에 의해 분해되는 과정에서 생성되는 비휘발성 아민으로 어류나 갑각류의 사후에 생성되는 물질들이다. 여기에는 cataverine, putrescine, spermidine, spermine, tyramine, trytamine 및 histamine 등이 속해있다. 이들은 어류나 갑 각류의 조직에 함유된 특정 유리아미노산의 탈탄산 (decarboxylation) 반응에 의해 생성되는 것으로 알려져 있 다. 어류를 장시간 보관할 경우 어류에 있는 미생물에 의 해 유리아미노산이 biogenic amines으로 전환되어 이것을 섭취한 사람이 특이증세를 나타내게 된다. 식품 중에 낮 은 수준의 biogenic amines이 함유되어 있을 경우에는 섭 취 시에도 큰 문제가 일어나지 않지만 과량 섭취하였을 경우에는 아민의 이화작용이 저해되어 저혈압, 고혈압, 메 스꺼움, 구토, 발진 및 심계항진과 같은 생리적 증세를 나 ...
Withdrawal reactions are an important and well-recognised side effect of Seroxat and also occur with the other SSRIs. The MCA/CSM warned prescribers about the possibility of withdrawal reactions associated with Seroxat via an article in the Bulletin, XCurrent Problems in Pharmacovigilance in 1993. The CSM re-reviewed the issue of withdrawal reactions and possible dependence with Seroxat and the other SSRIs in 1998 99. From a detailed review of all available data, 5 Nov 2002 : Column 272W. the CSM concluded that all SSRIs may be associated with withdrawal reactions on stopping, but that on current evidence, they are not associated with dependence. As a result of this review, product information for all SSRIs was updated in relation to withdrawal reactions. This issue was also reviewed at a European level by the Committee on Proprietary Medicinal Products (CPMP), which reached similar conclusions. ...
we have immediate openings for PhD and PostDoc positions exploring emissions of biogenic volatile organic compounds, their atmospheric oxidation and related aerosol formation. Please forward to potential candidates ...
Enzyme inhibitors (certain biogenic amines, certain medicines) Enzyme competitors (biogenic amines) Enzyme genetic defects; Mast Cell Activation. Mast cells are part of the bodys defence system to protect against infection and injury. Mast cells contain histamine, heparin, prostaglandins and other pro-inflammatory mediators.
The Serotonin Fast Track ELISA Kit is intended for the measurement of Serotonin in a sample. Kit has a lead time of 3-4 weeks from order receipt.. ...
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Histamine formation in fish is dependent on the time/temperature conditions under which the fish is handled, and therefore time/temperature control needs to be taken into consideration from harvest through consumption. There are many fish harvesting metho
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Biogenic Ketones Review: Does Biogenic Ketones really work for weight loss? What are the Benefits of Biogenic Ketones Supplement? Get All Answers ...
The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
Collagen holds the body together, plumps skin, lubricates joints, and builds mucosal barriers to protect the body from pathogens. Broths contain gelatine - a protein-rich, bioavailable form of collagen.. Proline is an anti-inflammatory amino acid which builds healthy cartilage.. Glycine is an anti-inflammatory amino acid, vital for wound healing. The liver requires it to produce the antioxidant glutathione.. Glutamine & Arginine keep the gut lining healthy and well equipped to heal in the face of constant challenge. They are known to relieve colitis. They also benefit brain health.. Threonine is a biogenic amine vital for keeping the gut lining in good health.. Bone Marrow is the nutrient dense component of bone that generates stem and blood cells.. Minerals, including: calcium, phosphorus, magnesium, sulphur, sodium and potassium.. Glycosaminoglycans (GAGs: including hyaluronic acid, chondroitin, glucosamine, chondroitin and keratan sulphate) are hydrophilic (water-attracting) proteins. They ...
Materials. Dopamine, norepinephrine, serotonin, indatraline, methylphenidate, desipramine, citalopram, raclopride, SKF86466, and methiothepin were purchased from Sigma-Aldrich (St. Louis, MO). Dulbeccos modified Eagles medium (DMEM), 100× nonessential amino acids, fetal bovine serum, 100× penicillin/streptomycin, Geneticin (G418), and trypsin/EDTA were purchased from Invitro-gen (Carlsbad, CA). Dual-Luciferase Reporter Assay System kit, pGL4.73, and Passive Lysis Buffer (5×) were obtained from Promega (Madison, WI). [3H]Dopamine (60 Ci/mmol), [3H]norepinephrine (49.5 Ci/mmol), and [3H]serotonin (20.3 Ci/mmol) were purchased from PerkinElmer Life and Analytical Sciences (Boston, MA). ReadySafe cocktail was obtained from Beckman Coulter (Fullerton, CA). The expression constructs of human α2A, α2B, 5-HT1A, and 5-HT1B were purchased from UMR cDNA Resource Center (Rolla, MO). Rhesus monkey dopamine D2 receptor short isoform (D2s) was constructed in pcDNA3.1(+) in our laboratory.. Cell Culture ...
In vertebrates, biogenic amines such as dopamine, serotonin, epinephrine and norepinephrine act physiologically as neurotransmitters, neuromodulators and neurohormones to regulate many important processes. In contrast, norepinephrine and epinephrine do not appear to be present in insects, as they lack dopamine β-hydroxylase that converts dopamine to norepinephrine. In fact, their role is fulfilled by their invertebrate counterparts, the monoamines tyramine and octopamine. The insect biogenic amines carry out many of the physiological roles such as reproduction, development, growth, circadian rhythms, endocrine secretion, and behaviors. They exert their effects by binding to specific receptor proteins that belong to the superfamily of G-protein coupled receptors (GPCRs), many of which have been characterized not only from Drosophila but also from several other insect species. Thus, blocking or over stimulating these GPCRs in pest insects may either result in the death or reduce fitness to ...
In an attempt to study the effects of several substances on intracellular cyclic adenosine 3′:5′-monophosphate (cAMP) concentration in tumor cells, lymphoma cells were incubated with biogenic amines (histamine, norepinephrine, epinephrine, and isoproterenol), prostaglandin E1 (PGE1), and Vinca alkaloids (vincristine and vinblastine). All substances tested increased intracellular cAMP in the presence of theophylline. Combined administration of Vinca alkaloid with biogenic amines or PGE1 produced an additive increase of cAMP in lymphoma cells. Vinca alkaloids depressed cAMP phosphodiesterase activity, but this depression was too weak to explain an increase of cAMP. In lymphoma cell homogenate, biogenic amines and PGE1 increased cAMP but Vinca alkaloids failed to do so, suggesting destruction of the receptor and/or transducer mechanism for Vinca alkaloids by homogenization. The effect of biogenic amines, PGE1, and Vinca alkaloids on cAMP was depressed by pretreatment of lymphoma cells with ...
Bacterial vaginosis (BV) is the most common vaginal disorder among reproductive age women. One clinical indicator of BV is a fishy odor. This odor has been associated with increases in several biogenic amines (BAs) that may serve as important biomarkers. Within the vagina, BA production has been linked to various vaginal taxa, yet their genetic capability to synthesize BAs is unknown. Using a bioinformatics approach, we show that relatively few vaginal taxa are predicted to be capable of producing BAs. Many of these taxa (Dialister, Prevotella, Parvimonas, Megasphaera, Peptostreptococcus, and Veillonella spp.) are more abundant in the vaginal microbial community state type (CST) IV, which is depleted in lactobacilli. Several of the major Lactobacillus species (L. crispatus, L. jensenii, and L. gasseri) were identified as possessing gene sequences for proteins predicted to be capable of putrescine production. Finally, we show in a small cross sectional study of 37 women that the BAs putrescine,
Ingestion of fermented foods containing high levels of biogenic amines (BA) can be deleterious to human health. Less obvious is the threat posed by BA producing organisms contained within the food whi
The trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine neurotransmitters. It is currently thought that the biological activities elicited by trace amines such as p-tyramine and the psychostimulant amphetamines are manifestations of their ability to inhibit the clearance of extracellular transmitter and/or stimulate the efflux of transmitter from intracellular stores. Here we report the discovery and pharmacological characterization of a rat G protein-coupled receptor that stimulates the production of cAMP when exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine. An extensive pharmacological survey revealed that psychostimulant and hallucinogenic amphetamines, numerous ergoline derivatives, adrenergic ligands, and 3-methylated metabolites of the catecholamine neurotransmitters are also good agonists at the rat trace amine receptor 1 (rTAR1). These results suggest that the trace amines and catecholamine ...
A Perspective on Biogenic Reefs and SACs The distribution of major examples of biogenic reefs is given by species in Table 3 and Figure 2, both within cSACs and pSACs, and elsewhere. No currently proposed SACs were selected specifically on the basis that they contain biogenic reefs. However, biogenic reefs are sub-features of other Annex I features such as reefs , estuaries or large shallow inlets and bays . In some cases biogenic reefs are specifically mentioned as reasons why a site is a particularly good example of an Annex 1 habitat e.g. Mytilus in Morecambe Bay, Modiolus in Strangford Lough, Lleyn Peninsula and the Sarnau and Loch Maddy; Sabellaria alveolata in the Solway Firth and Morecambe Bay. There are candidate SACs selected on the basis of the presence of reefs which do have substantial areas of Modiolus reef (Lochs Duich, Long and Alsh, Lleyn Peninsula and the Sarnau), Sabellaria alveolata reef (Lleyn Peninsula and the Sarnau); and probably Sabellaria spinulosa reef (Lleyn Peninsula ...
Looking for online definition of biogenic in the Medical Dictionary? biogenic explanation free. What is biogenic? Meaning of biogenic medical term. What does biogenic mean?
Objective: To evaluate the activities of Na+,K+-ATPase and Mg2+-ATPase in erythrocyte membranes from phenylketonuric (PKU) patients and to correlate the enzyme activities with their blood phenylalanine (Phe) levels, biogenic amines as well as with their precursors tyrosine (Tyr) and tryptophan (Try). Design and methods: Twenty three PKU patients were divided into group A (n = 12) on a stricted diet (Phe 1.57 ± 0.52 mg/dL or 0.10 ± 0.03 mM) and group B (n = 11) on a loose diet (Phe 24.45 ± 1.50 mg/dL or 1.72 ± 0.09 mM). The enzyme activities were measured spectrophotometrically, the amino acids with an automatic amino analyser and the biogenic amines with HPLC methods. Results: In group B, plasma amino acids (Tyr, Try), their biogenic amines [adrenaline (A), noradrenaline (NA), dopamine (DA) and serotonin (5HT)], (Na+,K+)-ATPase and Mg2+-ATPase activities were found remarkably decreased (p , 0.001). Conclusions: High Phe and/or low NA, DA, 5HT plasma levels may indirectly inhibit the ...
Polyamines and biogenic amines are chemicals derived from amino acids. Polyamines are involved in intracellular signals. Biogenic amines function in intercellular communication. Epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) targets the pathways of biogenic amines and polyamines. This is of therapeutic interest in treating cancer. Tea is, also, a source of the amino acid, theanine, […]. View Post ...
The purpose of this study was to elucidate the characteristics and mechanisms of adsorption and desorption for heavy metals by micro and nano-sized biogenic CaCO3 induced by Bacillus subtilis, and the pH effect on adsorption was investigated. The results showed that the adsorption characteristics of Cd2+ and Pb2+ are well described by the Langmuir adsorption isothermal equation, and the maximum adsorption amounts for Cd2+ and Pb2+ were 94.340 and 416.667 mg/g, respectively. The maximum removal efficiencies were 97% for Cd2+, 100% for Pb2+, and the desorption rate was less than 3%. Further experiments indicated that the biogenic CaCO3 could maintain its high adsorption capability for heavy metals within wide pH ranges (3-8). The FTIR and XRD results showed that, after the biogenic CaCO3 adsorbed Cd2+ or Pb2+, it did not produce a new phase, which indicated that biogenic CaCO3 and heavy metal ions are governed by a physical adsorption process, and the high adsorptive capacity of biogenic CaCO3 for Cd2+
Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists - and hence, monoaminergic neuromodulators - that are structurally and metabolically related to classical monoamine neurotransmitters. Compared to the classical monoamines, they are present in trace concentrations. They are distributed heterogeneously throughout the mammalian brain and peripheral nervous tissues and exhibit high rates of metabolism. Although they can be synthesized within parent monoamine neurotransmitter systems, there is evidence that suggests that some of them may comprise their own independent neurotransmitter systems. Trace amines play significant roles in regulating the quantity of monoamine neurotransmitters in the synaptic cleft of monoamine neurons with co-localized TAAR1. They have well-characterized presynaptic amphetamine-like effects on these monoamine neurons via TAAR1 activation; specifically, by activating TAAR1 in neurons they promote the release and prevent reuptake of ...
This book introduces a novel concept to reduce histamine in food that would benefit both food processors and food consumers. Histamine oxidizing bacteria and enzymes were utilized to degrade preformed histamine, as an emerging approach. This is the first time that an enzyme has been used to reduce histamine in food for human consumption. The histamine oxidizing enzyme was found to completely degrade histamine in tuna soup used to produce Rihaakuru, which is a nutritious and shelf-stable, cooked fish paste of the Maldives, consumed as a side dish. It is generally produced from poor quality fish therefore presence of biogenic amines is suspected. Rihaakuru was found to contain ten different biogenic amines, with histamine in excess of 500 ppm. This may cause histamine poisoning with symptoms such as skin rashes, vomiting and fever. Most of the histamine is likely to be produced by bacteria in raw fish. These bacteria are likely to die during the production of Rihaakuru, however, the histamine ...
Biogenic amine transporters play important roles in the action and recycling of their specific neurotransmitter substrates. They have been well established as t...
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
The Blakely Lab explores the molecular basis for neurotransmitter transporter structure, function and regulation. Chimera, site-directed mutagenesis and site-specific chmical modification strategies are used to explore the topology and quaternary structure of biogenic amine transporters. The lab evaluates what molecules control the proper localization and activity of transporter proteins using genetic (C. elegans) and molecular biologic methods. The Blakely Lab is also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters, and confer increased risk for autonomic, neurologic and mental disorders. For additional information, visit the Blakely Lab Website.  
The Blakely Lab explores the molecular basis for neurotransmitter transporter structure, function and regulation. Chimera, site-directed mutagenesis and site-specific chmical modification strategies are used to explore the topology and quaternary structure of biogenic amine transporters. The lab evaluates what molecules control the proper localization and activity of transporter proteins using genetic (C. elegans) and molecular biologic methods. The Blakely Lab is also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters, and confer increased risk for autonomic, neurologic and mental disorders. For additional information, visit the Blakely Lab Website.  
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Conventional supported amine adsorbents to date are known to suffer from the trade-off between increasing amine content and decreasing access to amine sites. In this work, we propose a solution to this known issue by introducing substrates with multiple pore networks where each pore channel can be used for a
Biogenic sources contribute to cloud condensation nuclei (CCN) in the clean marine atmosphere, but few measurements exist to constrain climate model simulations of their importance. The chemical composition of individual atmospheric aerosol particles showed two types of sulfate-containing particles in clean marine air masses in addition to mass-based Estimated Salt particles. Both types of sulfate particles lack combustion tracers and correlate, for some conditions, to atmospheric or seawater dimethyl sulfide (DMS) concentrations, which means their source was largely biogenic. The first type is identified as New Sulfate because their large sulfate mass fraction (63% sulfate) and association with entrainment conditions means they could have formed by nucleation in the free troposphere. The second type is Added Sulfate particles (38% sulfate), because they are preexisting particles onto which additional sulfate condensed. New Sulfate particles accounted for 31% (7 cm(-3)) and 33% (36 cm(-3)) CCN ...
TY - JOUR. T1 - Emerging Roles for Serotonin in Regulating Metabolism. T2 - New Implications for an Ancient Molecule. AU - Yabut, Julian M.. AU - Crane, Justin D.. AU - Green, Alexander E.. AU - Keating, Damien J.. AU - Khan, Waliul I.. AU - Steinberg, Gregory R.. PY - 2019/5/10. Y1 - 2019/5/10. N2 - Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for billions of years. In mammals, serotonin produced within the central nervous system regulates behavior, suppresses appetite, and promotes energy expenditure by increasing sympathetic drive to brown adipose tissue. In addition to these central circuits, emerging evidence also suggests an important role for peripheral serotonin as a factor that enhances nutrient absorption and storage. Specifically, glucose and fatty acids stimulate the release of serotonin from the duodenum, promoting gut peristalsis and nutrient absorption. Serotonin also enters the bloodstream and interacts ...
www.MOLUNA.de Stimulants [4206823] - 1 Amphetamines: Structure-Activity Relationships.- 1. Introduction.- 2. Effects of Biogenic Amines.- 2.1. Norepinephrine.- 2.2. Dopamine.- 2.3. Serotonin.- 3. Central Stimulatory Effects.- 3.1. Phenethylamine Derivatives.- 3.2. Structurally Modified Phenethylamine Derivatives.- 3.3. Pemoline.- 4. Anorexic Effects.- 5. Inhibition of Monoamine Oxidase.- 6. Psychotomimetic Effects.- 7. Summary.- 8. References.- 2 Amphetamines: Biochemical and
The learning and memory deficits have been recognized as severe and consistent neurological disorders associated with numerous neurodegenerative states. Research in this area has gained momentum only in the recent past after the biochemical and physiological basis of these processes have been understood. A considerable alteration in the neurotransmission is a consistent finding in cognitive disorders. Therefore, many therapeutic strategies to augment the concentration of neurotransmitters in brain such as cholinergic agents, biogenic amines and neuropeptides etc. have been evaluated in cognitive deficits. CNS modulators are the type of antiamnesics that act via modulation of the neurological processes underlying memory storage. These include psychostimulants, excitatory amino acids and most important of all nootropics. Nootropics are a heterogeneous group of compounds of diverse chemical composition and biological function that allegedly facilitate learning and memory or overcome natural or ...
The most important biogenic amine, histamine impacts health & behavior through its four receptors. Discover its function & genetics here.
Cold-water corals form substantial biogenic habitats on continental shelves and in deep-sea areas with topographic highs, such as banks and seamounts. In the Atlantic, many reef and mound complexes...
Heine D, Sundaram S, Beudert M, Martin K, Hertweck C (2016) A widespread bacterial phenazine forms conjugates with biogenic thiols and crosslinks proteins. Chem Sci 7, 4848-4855. PDF ...
BioAssay record AID 1053182 submitted by The Scripps Research Institute Molecular Screening Center: Counterscreen for antagonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based late stage dose response assay to identify TAAR1 Agonists (MedChem Round 2).
Copyright Get Revising 2017 all rights reserved. Get Revising is one of the trading names of The Student Room Group Ltd. Register Number: 04666380 (England and Wales), VAT No. 806 8067 22 Registered office: International House, Queens Road, Brighton, BN1 3XE ...
பூமியின் வயது ஏறத்தால 4.54 பில்லியன் வருடங்களாகும்[2][3][4] . புவியில் உயிர்களின் தொடக்கம் 3.5 பில்லியன் ஆண்டுகளுக்கு முன் என அறிவியல் ஆதாரங்கள் கூறுகின்றன [5][6]. புவியில் உயிர் தோன்றியதற்கான மிகச் சமீபத்திய ஆதாரமாக மேற்கு கிரீன்லாந்தில் கண்டுபிடிக்கப்பட்ட 3.7 பில்லியன் ஆண்டுகள் வயதான படிவுப்பாறைகளில் வன் கரிப்பொருளில் (graphite) உயிரிய படிவு (biogenic) காணப்பட்டிருக்கின்றன[7].மற்றும் மேற்கு ...
பூமியின் வயது ஏறத்தால 4.54 பில்லியன் வருடங்களாகும்[2][3][4] . புவியில் உயிர்களின் தொடக்கம் 3.5 பில்லியன் ஆண்டுகளுக்கு முன் என அறிவியல் ஆதாரங்கள் கூறுகின்றன [5][6]. புவியில் உயிர் தோன்றியதற்கான மிகச் சமீபத்திய ஆதாரமாக மேற்கு கிரீன்லாந்தில் கண்டுபிடிக்கப்பட்ட 3.7 பில்லியன் ஆண்டுகள் வயதான படிவுப்பாறைகளில் வன் கரிப்பொருளில் (graphite) உயிரிய படிவு (biogenic) காணப்பட்டிருக்கின்றன[7].மற்றும் மேற்கு ...
பூமியின் வயது ஏறத்தால 4.54 பில்லியன் வருடங்களாகும்[2][3][4] . புவியில் உயிர்களின் தொடக்கம் 3.5 பில்லியன் ஆண்டுகளுக்கு முன் என அறிவியல் ஆதாரங்கள் கூறுகின்றன [5][6]. புவியில் உயிர் தோன்றியதற்கான மிகச் சமீபத்திய ஆதாரமாக மேற்கு கிரீன்லாந்தில் கண்டுபிடிக்கப்பட்ட 3.7 பில்லியன் ஆண்டுகள் வயதான படிவுப்பாறைகளில் வன் கரிப்பொருளில் (graphite) உயிரிய படிவு (biogenic) காணப்பட்டிருக்கின்றன[7].மற்றும் மேற்கு ...
A field campaign to elucidate the impact of biogenic aerosols on clouds and climate, Petäjä, T., OConnor E.J., Moisseev D., Sinclair V.A., Manninen A.J., Väänänen R., Von Lerber A., Thornton J.A., Nicoll K., Petersen W., et al. , Bulletin of the American Meteorological Society, Volume 97, Number 10, p.1909-1928, (2016) ...
Definition: Component found in mineralized tissue, (a specialized form of biogenic tissue in which the extracellular matrix is mineralized ...
Definition: Component found in mineralized tissue, (a specialized form of biogenic tissue in which the extracellular matrix is mineralized ...
Other biogenic amines may also have an effect. RWH could be caused by the release of prostaglandins which some people are not ...
Biogenic amines. Monoamines. *6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ...
Biogenic amines: Monoamines: 6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ...
... the amine becomes quaternized to give betaine, a natural product: H. 3N+. CH. 2COO−. + 3 CH3I → (CH. 3). 3N+. CH. 2COO−. + 3 HI ... Biogenic amines. Monoamines. *6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ... The amine undergoes the expected reactions. With acid chlorides, one obtains the amidocarboxylic acid, such as hippuric acid[23 ... the French chemist Auguste Cahours determined that glycine was an amine of acetic acid.[16] ...
Biogenic amine. *Trace amine. *Monoamine nuclei. References[edit]. *^ Mele, Tina; Čarman-Kržan, Marija; Jurič, Damijana Mojca ( ... Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) ... Trace amines. *Phenethylamines (related to catecholamines): *Phenethylamine[7][8][9] (PEA). *N-Methylphenethylamine[10][7][9] ( ... Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends Pharmacol. Sci. 26 ( ...
Biogenic amines: Monoamines: 6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ...
Biogenic amines: Monoamines: 6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ... At pH values between about 2.5 and 4.1,[6] the carboxylic acid closer to the amine generally loses a proton, and the acid ... Transamination can thus be linked to deamination, effectively allowing nitrogen from the amine groups of amino acids to be ...
Biogenic amines: Monoamines: 6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ...
Biogenic amines: Monoamines: 6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ...
VMAT2 is the CNS vesicular transporter for not only the biogenic amines DA, NE, EPI, 5-HT, and HIS, but likely also for the ... Small: Trace amine (Phe). N-methylphenethylamine. NMPEA. hTAAR1. -. Small: Trace amine (Phe/Tyr). Tyramine. TYR. hTAAR1, hTAAR2 ... Small: Trace amine (Phe/Tyr). Synephrine. Syn. hTAAR1. -. Small: Trace amine (Trp). Tryptamine. hTAAR1, various serotonin ... Small: Trace amine (Phe). Phenethylamine. PEA. Human trace amine-associated receptors: hTAAR1, hTAAR2. -. ...
These signaling molecules include hormones and growth factors in turn are composed of peptides, biogenic amines, steroid ... This is because venom constituents (peptides, enzymes, nucleotides, lipids, biogenic amines etc.) often have very specific ... Biogenic substance Ethnobotany Pharmacognosy Phytotherapy Secondary metabolite Chemistry of Natural Compounds Journal of ...
1994). "Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate ... 1995). "Studies of the biogenic amine transporters. VI. Characterization of a novel cocaine binding site, identified with [125I ... further evidence for phencyclidine binding sites associated with the biogenic amine reuptake complex". Synapse. 8 (4): 289-300 ...
"Intolerance to dietary biogenic amines: a review". Annals of Allergy, Asthma & Immunology. 91 (3): 233-240, quiz 241-242, 296. ...
About 30% of people are sensitive to biogenic amines, such as histamines.[72] ... The amines in red wine and Chardonnay produce off-flavors and cause headaches and hypertension in some people. ... Researchers from the University of British Columbia, Canada, have found a new strain of yeast that has reduced amines. ...
2005). "A survey on free biogenic amine content of fresh and preserved vegetables". Food Chemistry. Elsevier. 89 (3): 355-361. ...
... release neuropeptides and amino acids in addition to classical neurotransmitters such as acetylcholine or biogenic amines (see ...
... and alpha-methyltyrosine on brain biogenic amines". Federation Proceedings. 35 (14): 2558-2562. PMID 11134.. .mw-parser-output ...
"Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology. ... References for all endogenous human TAAR1 ligands are provided at List of trace amines ...
"Comparative actions of monomethoxyamphetamines on the release and uptake of biogenic amines in brain tissue". The Journal of ...
This structural motif has potential for high affinity binding to biogenic amine transports.[28] Drugs containing an ... This is because of a formation of secondary amine TCA metabolites.[24][25] ... The mechanism of action of tricyclic secondary amine antidepressants is only partly understood. TCAs have dual inhibition ... 3-arylpropan-1-amines". Bioorganic & Medicinal Chemistry. 14 (24): 8455-66. doi:10.1016/j.bmc.2006.08.039. PMID 16973367.. ...
"Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar ...
"Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients". ... U.S. Patent 3,308,160PHENYLBICYCLO[Z.Z.Z]OCTANE-L-AMINES AND SALTS THEREOF. Learned, S; Graff, O; Roychowdhury, S; Moate, R; ... However, elation may be associated with an excess of such amines." Shortly after Schildkraut's catecholamine hypothesis was ...
"Intolerance to dietary biogenic amines: a review". Annals of Allergy, Asthma & Immunology. svezak 91 (broj 3): str. 233.-240.; ...
Monoamine oxidase inhibitors allow reuptake of biogenic amine neurotransmitters from the synapse, but inhibit an enzyme which ... Tricyclic antidepressants also block reuptake of biogenic amines from the synapse, but may primarily effect serotonin or ...
"Occurrence of biogenic amine-forming lactic acid bacteria in wine and cider". Food Microbiology. 27 (8): 1078-1085. doi:10.1016 ...
The main component of bee venom responsible for pain in vertebrates is the toxin melittin; histamine and other biogenic amines ...
Markianos M, Alevizos V, Stefanis C (1991). "Plasma sex hormones and urinary biogenic amine metabolites during treatment of ... No significant rise in blood pressure occurs when moclobemide is combined with amines such as tyramine-containing foods or ... Single or repeated dosing with 100-300 mg of moclobemide leads to a reduction in deaminated metabolites of amines such as 3,4- ... The reversible binding to MAO-A by moclobemide allows amines such as tyramine to displace moclobemide from MAO-A allowing its ...
"Long-Acting Blockade of Biogenic Amine Transporters in Rat Brain by Administration of the Potent Novel Tropane 2β-Propanoyl-3β ...
... and alpha-methyltyrosine on brain biogenic amines". Federation proceedings 35 (14): 2558-2562. PMID 11134. ...
... biogenic amine, phenylethanolamine, to the adrenergic drug synephrine, and to the alkaloid ephedrine. The pharmacological ... G. Barger and H. H. Dale (1910)."Chemical structure and sympathomimetic action of amines." J. Physiol. 41 19-59. K. K. Chen, C ... Chemically, N-methylphenyethanolamine is an aromatic compound, an amine, and an alcohol. The amino-group makes this compound a ... J. Armstrong and R. B. Barlow (1976). "The ionization of phenolic amines, including apomorphine, dopamine and catecholamines ...
The Klemetsrud Plant at Oslo, Norway use biogenic municipal solid waste to generate 175 GWh and capture 315 Ktonne of CO2 each ... It uses absorption technology with Aker Solution Advanced Amine solvent as a CO2 capture unit. Similarly, the ARV Duiven at ...
Important amines include amino acids, biogenic amines, trimethylamine, and aniline; see Category:Amines for a list of amines. ... Cyclic amines-Cyclic amines are either secondary or tertiary amines. Examples of cyclic amines include the 3-membered ring ... Lower amines are named with the suffix -amine.. methylamine Higher amines have the prefix amino as a functional group. IUPAC ... "Amine definition and meaning". Collins English Dictionary. Retrieved 2017-03-28.. *^ "amine - definition of amine in English". ...
Similarly, urinary biogenic trace amine PEA levels could be a biomarker for the diagnosis of ADHD,20,57,58 for treatment ... The biogenic amines, phenethylamine and tyramine, are N-oxygenated by FMO to produce the N-hydroxy metabolite, followed by a ... Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) ... "Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications". Front. ...
biogenic amines *Histamine. *Serotonin. synthesized on demand:. *cytokines *IFN-γ. *IL-8 ...
... through activation of a trace amine receptor, increases biogenic amine and excitatory neurotransmitter activity in the brain, ... Methamphetamine (contracted from N-methyl-alpha-methylphenethylamine) is a neurotoxin and potent psychostimulant of the ... Ephedrine is a sympathomimetic amine similar in molecular structure to the well-known drugs phenylpropanolamine and ... Many drugs in this class work primarily by activating trace amine-associated receptor 1 (TAAR1);[38] in turn, this causes ...
Most LAB have the potential to create biogenic amines, even some strains of O. oeni, but high levels of biogenic amines are ... Finally, O. oeni tends to produce the least amount of biogenic amines (and most lactic acid[3]) among the lactic acid bacteria ... Biogenic amines have been implicated as a potential cause of red wine headaches. In wine, histamine, cadaverine, ... Cadaverine is one of the biogenic amines that some LAB species, particularly from the Lactobacillus and Pediococcus genera, ...
The fishy smell of dead fish is due to the breakdown of amino acids into biogenic amines and ammonia.[46] ...
About 30% of people are sensitive to biogenic amines, such as histamines.[68] ... The amines in red wine and Chardonnay produce off-flavors and cause headaches and hypertension in some people. ... Researchers from the University of British Columbia, Canada, have found a new strain of yeast that has reduced amines. ...
Biogenic amine receptor. *Olfactory receptor. Class B. *Secretin receptor. Class C. *Metabotropic glutamate receptor ...
Biogenic amines. *Ethylamines. *Imidazoles. *Immune seestem. *Vasodilators. *Immunostimulants. *Neurotransmitters. *TAAR1 ...
"Analysis of biogenic amines and their metabolites in biological tissues and fluids by gas chromatography-negative ion chemical ... "HPLC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine ... a b B. Avula, S. K. Upparapalli, and I. A. Khan (2007). "Simultaneous analysis of adrenergic amines and flavonoids in citrus ... Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends Pharmacol. Sci. 26 ( ...
GPCRs respond to extracellular signals mediated by a huge diversity of agonists, ranging from proteins to biogenic amines to ... biogenic amines (e.g., dopamine, epinephrine, norepinephrine, histamine, serotonin, and melatonin); glutamate (metabotropic ...
Most natural gas was created over time by two mechanisms: biogenic and thermogenic. Biogenic gas is created by methanogenic ... Amine gas treating, an industrial scale process which removes acidic gaseous components, is often used to remove hydrogen ...
biogenic amines *Histamine. *Serotonin. synthesized on demand:. *cytokines *IFN-γ. *IL-8 ...
... but the other biogenic amines from the cocoa do) Nuts Products with vinegar, such as pickles or mustard Soy and soy products (e ...
Babusyte A, Kotthoff M, Fiedler J, Krautwurst D (March 2013). "Biogenic amines activate blood leukocytes via trace amine- ... Trace amine-associated receptors (TAARs), sometimes referred to as trace amine receptors (TAs or TARs), are a class of G ... Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) ... Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T (February 2013). "Ultrasensitive detection of amines by a trace amine- ...
The Serotonin Fast Track ELISA Kit is intended for the measurement of Serotonin in a sample. Kit has a lead time of 3-4 weeks from order receipt.. ...
... final concentrations of biogenic amines and ochratoxin, which facilitates exports. ... Lowering biogenic amines and ochratoxin in wines Bio-protection helps reducing wines final concentrations of biogenic amines ... Our team of wine experts can diagnosis the primary sources of biogenic amines or ochratoxin A in grapes or within the winery. ... flora-present on the grapes contain many molds and bacteria that may produce either biogenic amines from amino acids such as ...
What is biogenic amine hypothesis? Meaning of biogenic amine hypothesis as a legal term. What does biogenic amine hypothesis ... Definition of biogenic amine hypothesis in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Related to biogenic amine hypothesis: biogenic amine theory, dysregulation hypothesis Hypothesis. An assumption or theory. ... Biogenic amine hypothesis legal definition of biogenic amine hypothesis https://legal-dictionary.thefreedictionary.com/biogenic ...
Biogenic amines in Portuguese traditional foods and wines. .ui-tooltip { max-width:600px !important; } ... Biogenic amines in Portuguese traditional foods and winesExportar publica o no formato APAExportar publica o no formato EXCEL ... Voc est em: In cio , Publica es , Visualiza o , Biogenic amines in Portuguese traditional foods and wines ... Abstract (EN): The presence of biogenic amines in foodstuffs is an important food safety problem because of the implication of ...
Public Health Risks of Histamine and Other Biogenic Amines from Fish and Fisheries Products. Food and Agriculture Organization ... Public Health Risks of Histamine and Other Biogenic Amines from Fish and Fisheries Products ...
Effect of controlled and modified atmospheres on the production of biogenic amines and free amino acids during storage of hake ... Free amino acids (FAAs) and biogenic amines were determined in whole hake (Merluccius merluccius L) stored in bulk under ... Significant differences (P≤0.05) were observed in the biogenic amine concentrations among the lots kept under special ... arginine and ornithine initial concentrations and the increases in their corresponding biogenic amine concentrations (histamine ...
Biogenic amines as biochemical markers of autism: a review. Hao X. 1, Pei S. 2, Zhu M. 1, Cai Y. 1, Liu S. 1, Wen C. 1, Cao J. ... Hao X, Pei S, Zhu M, Cai Y, Liu S, Wen C, et al. Biogenic amines as biochemical markers of autism: a review. Minerva Biotec ... This review is a compilation of the reports on peripheral alterations of the biogenic amines of the tryptophan pathway in ASD. ... Although there are umpteen biomarkers identified in relation to ASD, abnormalities in biogenic amines from the tryptophan ...
Manca, G., Ru, A., Siddi, G., Mocci, A., Murittu, G., & De Santis, E. (2020). Biogenic amines content in Fiore Sardo cheese in ... Biogenic amines content in Fiore Sardo cheese in relation to free amino acids and physicochemical characteristics ... presenting risk factors due to an accumulation of Biogenic Amines (BA). A total of 37 Fiore Sardo cheese samples produced in 19 ... Biogenic amines content in Fiore Sardo cheese in relation to free amino acids and physicochemical characteristics https://doi. ...
A large number of biogenic amines ELISA kits are available, these organic bases are formed by decarboxylation of amino acids or ... Biogenic Amines Elisa Kits. A large number of biogenic amines ELISA kits are available, these organic bases are formed by ...
WP1118: Biogenic Amine Synthesis. WP125: Biogenic Amine Synthesis. WP154: Biogenic Amine Synthesis. WP323: Biogenic Amine ... Biogenic Amine Synthesis. pathways : Biogenic Amine Synthesis Fullview (zoomIn). Related Pathways to "Biogenic Amine Synthesis ... Tide Fluor 8WS amine [TF8WS amine] *Near Infrared Emission*. 1 mg. B1420 B2140 B3400. Tide Quencher™ 4WS amine [TQ4WS amine]. 1 ... Tide Quencher™ 6WS amine [TQ6WS amine]. 1 mg. 2246. Tide Fluor™ 2 amine [TF2 amine] *Superior replacement to fluorescein*. 1 mg ...
biogenic amine: a biologically synthesized substance, fundamentally a nitrogen compound, widely dispersed in the body. Some ...
Spoilage Detection with Biogenic Amine Biosensors, Comparison of Different Enzyme Electrodes. Beáta Bóka, N. Adányi, Diána ... Spoilage Detection with Biogenic Amine Biosensors, Comparison of Different Enzyme Electrodes. / Bóka, Beáta; Adányi, N.; Virág ... Bóka B, Adányi N, Virág D, Sebela M, Kiss A. Spoilage Detection with Biogenic Amine Biosensors, Comparison of Different Enzyme ... Spoilage Detection with Biogenic Amine Biosensors, Comparison of Different Enzyme Electrodes. In: Electroanalysis. 2012 ; Vol. ...
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In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development. show less ... Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers : Findings from a prospective cohort study. ... biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large ...
Brain Biogenic Amine Depletion and Mood. / Mendels, Joseph; Frazer, Alan.. In: Archives of General Psychiatry, Vol. 30, No. 4, ... Mendels, J., & Frazer, A. (1974). Brain Biogenic Amine Depletion and Mood. Archives of General Psychiatry, 30(4), 447-451. ... Mendels, J & Frazer, A 1974, Brain Biogenic Amine Depletion and Mood, Archives of General Psychiatry, vol. 30, no. 4, pp. 447 ... Brain Biogenic Amine Depletion and Mood. In: Archives of General Psychiatry. 1974 ; Vol. 30, No. 4. pp. 447-451. ...
Biogenic amines (BAs) are organic amines present in meat, fish, dairy produce and wine due to the breakdown of amino acids, ... Determination of biogenic amines by thermal lens microscopic detection of enzymatically released ammonium. ... Four biogenic amines (putrescine, cadaverine, histamine and tyramine) were subjected to enzymatic catalysis by transglutaminase ...
Biogenic amine transporters: regulation in flux.. Blakely RD1, Bauman AL.. Author information. 1. Department of Pharmacology, ... Following vesicular release, the biogenic amine neurotransmitters dopamine, norepinephrine and serotonin are actively cleared ... Recent findings indicate that amine reuptake is likely to be a tightly regulated component of synaptic plasticity rather than a ... surface expression or protein levels of amine transporters raises new questions about the fundamental nature of drug actions in ...
Biogenic amine definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up ... Words nearby biogenic amine. biogen, biogenesis, biogenetic law, biogenetics, biogenic, biogenic amine, biogeochemical cycle, ... Any of a group of naturally occurring, biologically active amines, such as serotonin, that act primarily as neurotransmitters ...
Biogenic Amines and Body Temperature by K. E. Cooper from Waterstones today! Click and Collect from your local Waterstones or ... Drugs, Biogenic Amines and Body Temperature: 3rd Symposium on The Pharmacology of Thermoregulation, Banff, Alta., September ...
"biogenic amines". Entries tagged with: biogenic amines. 2 result(s) displayed (1 - 2 of 2): ... Read More: bacterial vaginosis, beta carotene, biogenic amines, chicken, dairy, desserts, douching, fat, fishy odor, fruits, pH ... Read More: abdominal fat, adiponectin, belly fat, biogenic amines, bologna, cellulite, cheese, cholesterol, colorectal polyps, ...
Build confidence in your biogenic amine analysis by relying on the durability offered by Enzyme immunoassays (EIAs) and Radio ... Biogenic amines are a group of naturally occurring amines derived by enzymatic decarboxylation of amino acids. Enzyme ... MP Biomedicals offers RIA and EIA Test Kits for the in vitro diagnostic (IVD) determination of biogenic amines in human serum, ... test kits provide the accurate assessment of various biogenic amine neurotransmitters, including dopamine, norepinephrine ( ...
The consumption of high amount of biogenic amines, above all histamine, can result in food borne poisoning which is a worldwide ... The consumption of high amount of biogenic amines, above all histamine, can result in food borne poisoning which is a worldwide ... Preventive measures and emerging methods aiming at controlling the production of biogenic amines are also reported for ... Preventive measures and emerging methods aiming at controlling the production of biogenic amines are also reported for ...
Therefore, biogenic amines monitoring in food samples is a matter of utmost importance, and their accurate determination is ... Finally, we focus on foods in which biogenic amines mainly occur such as fish, meat and wine and other fermented products. ... Under this context, we provide an overview over the most widely employed analytical techniques for biogenic amines ... Biogenic amines are low-molecular-mass substances, essential for proper health for all organisms. These compounds could be ...
U.S. Selective inhibitors of biogenic amine transporters. (U.S. Patent No. 5574060). ...
1951 first described the biogenic amine octopamine in the salivary gland of octopus as a molecule with ... Neuroanatomy of biogenic amine expression. -Functional dissection of neuronal circuitry modulated by biogenic amines. - ... As of today, the mechanism of release of biogenic amines is unknown. Do the neurons that express octopamine release octopamine ... We would like to elucidate in detail the "orchestrational" function of biogenic amines as their role in the periphery of ...
Spoilage pattern and biogenic amine formation are species specific. Histamine has been traditionally used as an indicator of ... Biogenic amines such as putrescine, tyramine and cadaverine can potentiate histamine toxicity. Furthermore, dietary polyamine ... There are several toxicological effects of biogenic amines on humans, especially histamine. It is the causative agent of ... Besides their potential toxicity, biogenic amines are used for the evaluation of hygienic quality of different marine and ...
Biogenic amine contents in fish and fish preserves]. Download Prime PubMed App to iPhone, iPad, or Android ... Assay of biogenic amines involved in fish decomposition.. *Biogenic amine content of shalgam (salgam): a traditional lactic ... 1. The occurrence of biogenic amines in silage.. *Changes in biogenic amines and microbiological analysis in albacore (Thunnus ... AmphetamineAnimalsBiogenic AminesCadaverineChromatography, LiquidFishesFood PreservationHistaminePutrescineSpermidineSpermine ...
The combination of the data indicates that all examined amines show antioxidant characteristics: in particular, tyramine, ... Antioxidant properties of the principal biogenic amines were determined in vitro by four analytical methods-Folin Ciocalteu, ... "In Vitro Preliminary Evidences on the Antioxidant Properties of Biogenic Amines" written by Roberto Stevanato, Mariangela ...
Effect of MAO inhibitors on the high-affinity reuptake of biogenic amines in rat subcortical regions.. Tekes K1, Magyar K. ...
Agonistic behaviour and biogenic amines in shore crabs Carcinus maenas. L.U. Sneddon, A.C. Taylor, F.A. Huntingford, D.G. ... Agonistic behaviour and biogenic amines in shore crabs Carcinus maenas. L.U. Sneddon, A.C. Taylor, F.A. Huntingford, D.G. ... Agonistic behaviour and biogenic amines in shore crabs Carcinus maenas. L.U. Sneddon, A.C. Taylor, F.A. Huntingford, D.G. ... Agonistic behaviour and biogenic amines in shore crabs Carcinus maenas Message Subject (Your Name) has sent you a message from ...
... formation pathway of biogenic amines [8-10]. As the consumption of food containing large amounts of these amines can have ... such as biogenic amines (BAs) which are nonvolatile amines formed by decarboxylation of amino acids. Natural polyamines are ... Table 5: Biogenic amines content in tea leaves. Data represent mean ± RSD (. ); . ... Table 6: Biogenic amines content in tea infusions. Data represent mean ± RSD (. ); . ...
Achetez Urine control for Biogenic Amines, level II, lyophillised de LGC Standards. Sidentifier ou senregistrer pour ...
Fermentation of food products: optimised lactic acid bacteria strains with reduced potential to accumulate biogenic amines. ... leads tithe production of bioorganic amines (BA) (e.g. histamine , tramline) which have undesirable toxic properties. The goal ...
Final Report Summary - COMPBAND (Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases) ... Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases. ... responsible for regulating amine levels in the synaptic region, and on histamine H2 receptor that is activated by the biogenic ... 0.3 is found in a very good agreement with the available experimental data for closely related biogenic amines, which gives ...
... the production of biogenic amines. The physiological effects of tyramine include peripheral vasoconstriction, increased cardiac ... The concentration of available free amino acids plays a fundamental role in the formation of amines in foods, in that they are ... The main mechanism of biogenic formation is the decarboxylation of free amino acids by specific enzymes of microbial origin, ... This chapter discusses the formation and degradation of biogenic amines, their occurrence in foods, their significance in food ...
Biogenic amines at nanomolar concentration is detected with the additional ability to discriminate between primary, secondary ... and tertiary amines by Recent Open Access Articles ... anhydride moiety for detection of aliphatic primary amines is ... N-dimethylaminonaphthalene anhydride moiety for detection of aliphatic primary amines is reported. Biogenic amines at nanomolar ... A ratiometric fluorescent probe for detection of biogenic primary amines with nanomolar sensitivity S. Mallick, F. Chandra and ...
Biogenic amine neurotransmitters in C. elegans* Daniel L. Chase1§, Michael R. Koelle2. 1Department of Biochemistry and ... Four biogenic amines: octopamine, tyramine, dopamine and serotonin act in C. elegans to modulate behavior in response to ... aBiogenic amine receptors identified by blast searches of the C. elegans genomic and protein databases14, 15, 9, 7. ... The biogenic amines dopamine, serotonin, octopamine and tyramine can all be detected in C. elegans extracts by HPLC analysis ...
Pathway:Human:Biogenic Amine Synthesis]] moved to [[Pathway:Homo sapiens:Biogenic Amine Synthesis]]: Renaming species. 7585. ... gpml file for [[Human:Biogenic_Amine_Synthesis]]. External references DataNodes. View all...", "View last 5...") style=cursor ... Pathway:Homo sapiens:Biogenic Amine Synthesis]] moved to [[Pathway:WP550]]: Moved to stable identifier. 15389. view. 22:23, 27 ... Ontology Term : biogenic amine biosynthetic pathway added !. 63146. view. 20:12, 8 May 2013. MaintBot. Updating GPML version ...
... in addition to the quantity of biogenic amines that arise during the decomposition of fish protein by microorganisms - i.e., ... Application report: Biogenic amines in fish. A number of different parameters are used to evaluate the freshness of fish. ... in addition to the quantity of biogenic amines that arise during the decomposition of fish protein by microorganisms - i.e., ...
... in addition to the quantity of biogenic amines that arise during the decomposition of fish protein by microorganisms - i.e., ... Application report: Biogenic amines in fish. A number of different parameters are used to evaluate the freshness of fish. ... in addition to the quantity of biogenic amines that arise during the decomposition of fish protein by microorganisms - i.e., ... Find out what Metrohm has to offer for the analysis fossil or biogenic products in accordance with international standards. ...
Advice for patients having tests to measure biogenic amines. *Plasma free metanephrine and normetanephrine updated and changed ...
Effects of biogenic amines on raphe-spinal tract cells.. W S Willcockson, K D Gerhart, C L Cargill and W D Willis ... Effects of biogenic amines on raphe-spinal tract cells.. W S Willcockson, K D Gerhart, C L Cargill and W D Willis ... Effects of biogenic amines on raphe-spinal tract cells.. W S Willcockson, K D Gerhart, C L Cargill and W D Willis ... Effects of biogenic amines on raphe-spinal tract cells. Message Subject (Your Name) has forwarded a page to you from Journal of ...
  • Wild, indigenous flora-sometimes also named 'spontaneous' flora-present on the grapes contain many molds and bacteria that may produce either biogenic amines from amino acids such as histamine, tyramine, putrescine or cadaverine or ochratoxin very early in the process. (chr-hansen.com)
  • Wines, specifically those in which lactic acid bacteria can grow can cause transient toxic effects due to the formation of biogenic amines such as histamine and tyramine. (oregonstate.edu)
  • In terms of synthesis, packaging, release, and degradation, the amine neurotransmitters fall somewhere between the properties of the other Cited by: 4. (menards.club)
  • Traditional foods are an important part of the Portuguese diet, and a high intake of harmful amounts of biogenic amines from traditional Portuguese fermented foods is possible. (up.pt)
  • Malolactic fermentation with VINIFLORA ® enological bacteria: by far the most efficient way to dramatically reduce the presence of biogenic amines in the final wine. (chr-hansen.com)
  • The presence of biogenic amines in foodstuffs is an important food safety problem because of the implication of these compounds in food intolerance and intoxication. (up.pt)
  • The separation and quantification of biogenic amines in foods is normally performed by chromatographic techniques. (up.pt)
  • This review contains descriptions of the quantification of biogenic amines in Portuguese traditional fermented and/or ripened foods and wines, including Protected Denomination of Origin cheeses, drycured sausages, and Portuguese wines (including Port wines), using different analytical methods based on high-pressure liquid chromatography (UV or diode array and/or fluorometric detectors) and gas chromatography (with a mass spectrometry detector). (up.pt)
  • The evolution of biogenic amines during fermentation, ripening, aging, or storage of those products was also evaluated. (up.pt)
  • Biogenic amine concentrations ranged widely within individual food items, and storage, transport, and handling conditions can influence to some extent the biogenic amines present and their concentrations. (up.pt)
  • Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that reported to occur in depressed patients. (uthscsa.edu)
  • Twenty Apulian and Sicilian cheeses were analysed for their concentrations of eight biogenic amines (BAs), free amino acids, pH, water activity, and subjected to microbiological characterisation. (unibz.it)
  • An understanding of the origin, occurrence and formation of amines in grape and berry wines will lead to developing approaches to preventing their formation. (oregonstate.edu)
  • Although partial extraction was achieved, the results correlate with total biogenic amine content measured by HPLC method. (elsevier.com)
  • Fiore Sardo is a Protected Designation of Origin (PDO) cheese produced in Sardinia (Italy) from raw sheep's milk, presenting risk factors due to an accumulation of Biogenic Amines (BA). (pagepressjournals.org)
  • To evaluate the hypothesis that clinical depression is associated with reduced brain biogenic amine activity, the behavioral effects, in man, of drugs that deplete the brain of biogenic amines were reviewed. (uthscsa.edu)
  • Jeganathan, PS & Namasivayam, A 1989, ' Brain biogenic amine levels after methanol administration: Possible mechanism of action of central monoaminergic neurons in discrete areas of brain in Wistar rats ', Indian Journal of Physiology and Pharmacology , vol. 33, no. 3, pp. 151-156. (elsevier.com)
  • Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or Amines of the adrenaline type. (menards.club)
  • Compounds such as histamine may have a severe effect on people suffering from intolerance, and the presence of ethanol in wine may enhance the effect of biogenic amines in sensitive people. (chr-hansen.com)
  • With diamine oxidase (EC 1.4.3.6), the total biogenic amine content was measured. (elsevier.com)
  • Our team of wine experts can diagnosis the primary sources of biogenic amines or ochratoxin A in grapes or within the winery. (chr-hansen.com)
  • Three enzyme based amperometric biosensors for biogenic amines were applied for meat spoilage monitoring. (elsevier.com)
  • Owing to inductive effects, the basicity of an amine might be expected to increase with the number of alkyl groups. (menards.club)
  • Although there are umpteen biomarkers identified in relation to ASD, abnormalities in biogenic amines from the tryptophan metabolism pathway have been more commonly implicated in ASD. (minervamedica.it)
  • Classify the following amines as primary, secondary or tertiary: (i) Write structures of different isomeric amines corresponding to the molecular formula, C 4 H 11 N. (ii) Write IUPAC names of all the isomers. (menards.club)
  • Primary amines. (menards.club)
  • In primary amines, only one of the hydrogen atoms in the ammonia molecule has been replaced. (menards.club)
  • That means that the formula of the primary amine will be RNH 2 where "R" is an alkyl group. (menards.club)
  • In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development. (uu.nl)
  • Enzyme Immunoassay (EIA) and Radioimmunoassay (RIA) test kits provide the accurate assessment of various biogenic amine neurotransmitters, including dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), histamine, melatonin and serotonin. (mpbio.com)
  • Thus, for this research topic we encourage scientists from different disciplines to participate in the study covered above subjects involving different types of biogenic amines and their receptors, including but not limited to tyramine, octopamine, serotonin, histamine, and dopamine. (frontiersin.org)
  • Wild, indigenous flora-sometimes also named 'spontaneous' flora-present on the grapes contain many molds and bacteria that may produce either biogenic amines from amino acids such as histamine, tyramine, putrescine or cadaverine or ochratoxin very early in the process. (chr-hansen.com)
  • Compounds such as histamine may have a severe effect on people suffering from intolerance, and the presence of ethanol in wine may enhance the effect of biogenic amines in sensitive people. (chr-hansen.com)
  • There are several toxicological effects of biogenic amines on humans, especially histamine. (biomedsearch.com)
  • Biogenic amines such as putrescine, tyramine and cadaverine can potentiate histamine toxicity. (biomedsearch.com)
  • A method developed on the basis of highly efficient liquid chromatography of dansyl derivatives was used to study the content of biogenic amines (tyramine, histamine, cadaverine, putrescine, spermine and spermidine) in fish and canned fish. (unboundmedicine.com)
  • Decarboxylation of did- and tricarboxylic acids by LAB is a desirable step resulting in the production of compounds which enhance the organoleptic properties and/or the stability of the finished products .However, decarboxylation of amino acids (e.g. histamine, tyrosine) leads tithe production of bioorganic amines (BA) (e.g. histamine , tramline) which have undesirable toxic properties. (europa.eu)
  • Therefore, the research performed in this project concentrated on two important biological systems, namely on monoamine oxidase enzymes (MAOs) responsible for regulating amine levels in the synaptic region, and on histamine H2 receptor that is activated by the biogenic amine histamine as its primary endogenous ligand to exert various regulatory actions. (europa.eu)
  • Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. (wikipathways.org)
  • In BIOAMINA we, the Austrian Institute of Technology, Health and Environment Department and the Danube University Krems, Center of Integrated Sensor Systems will contribute to this issue developing a multiplex diagnostic tool that is capable of reliably and simultaneously measuring histamine, tyramine, putrescine and other biogenic amines in test food, serum and urine. (donau-uni.ac.at)
  • A high concentration of histamine, one of the biogenic amines (BAs) usually found in fermented foods, can cause undesirable physiological side effects in sensitive humans. (scielo.br)
  • In all the samples, the levels of aromatic and heterocyclic amines with toxicological effects were: 0 4.58 mg/l for phenylethylamine, 0 10.51 mg/l for histamine, and 0 9.13 mg/l for tyramine. (infowine.com)
  • Chunjang samples contained relatively large amounts of histamine (up to 273mg/kg) and tyramine (up to 131mg/kg), whereas Jajang samples had relatively small amounts of biogenic amines (mostly less than 40mg/kg). (nih.gov)
  • Investigating in organ bath the vascular reactivity we demonstrated that such biogenic amines as noradrenalin, serotonin and histamine induced a more pronounced effects in the uterine artery rings extracted from patients with uterine cancer when the level of messenger RNA for Tph-1 in the tumour was lower. (cnaa.md)
  • There are five established biogenic amine neurotransmitters: the three catecholamines - dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) - and histamine and serotonin. (demeditec.com)
  • The most significant amines (average 10.8 mg/L for histamine+tyramine in red, and 7.4 mg/L for white wines) were found to be present at low levels and, although no important relationship between each individual biogenic amine could be obtained, the total amine content depends significantly on the assimilable amino acid content in wine. (studyres.com)
  • Biogenic amines in foods: histamine and food processing. (utb.cz)
  • The main biogenic amine is histamine. (sarco.fr)
  • Histamine is the most controlled biogenic amine. (sarco.fr)
  • The unicellular eukaryote Tetrahymena synthesize, store and secrete biogenic amines (histamine, serotonin, epinephrine, dopamine, melatonin) and also can take up amines from the milieu. (elsevier.com)
  • In my partner's case, it may not be general amines, but could be a histamine intolerance, or a reaction to mold. (findingmykryptonite.com)
  • We would like to elucidate in detail the "orchestrational" function of biogenic amines as their role in the periphery of modulating synaptic transmission and catabolic pathways is accompanied by specific actions within the nervous system, for example, motor circuits. (frontiersin.org)
  • Following vesicular release, the biogenic amine neurotransmitters dopamine, norepinephrine and serotonin are actively cleared from extracellular spaces by presynaptic transporters. (nih.gov)
  • Any of a group of naturally occurring, biologically active amines, such as serotonin, that act primarily as neurotransmitters and are capable of affecting mental functioning. (dictionary.com)
  • A simple method for the assay of brain biogenic amines by selected-ion monitoring was applied to examination of the effects of 3-iodo-L-tyrosine on the hypothalamic-median eminence concentrations of dopamine, noradrenaline and serotonin in the rat. (garvan.org.au)
  • Biogenic amines such as serotonin and norepinephrine are well known as neurotransmitters in the control and regulation of many brain functions, and have been strongly implicated in several pathological conditions such as aggressive and predatory behavior, migraine, depression and carcinoid syndrome. (nii.ac.jp)
  • It is very importnt to measure time-dependent changes of serotonin and/or norepinephrine levels for the investigations of the relationships between the amine levels and various pharmacentical activities. (nii.ac.jp)
  • This study demonstrated role played by biogenic amines, especially by serotonin, in the pathogenic mechanisms and pro oncogenic changes in endometrial cancer genesis. (cnaa.md)
  • Biogenic amines deficits correlate with specific brain atrophy patterns in adult PKU patients, in line with serotonin and dopamine projections. (mpg.de)
  • Agmatine and cadaverine in squid, cadaverine, and putrescine in white prawn were the most obviously changed amines during the storage at two different temperatures, and these biogenic amines could be the effective quality indicators for the freshness of the raw aquatic materials. (unboundmedicine.com)
  • The amines associated with sanitary conditions were also found to be present in a very low range, between 0 and 12.98 mg/l for putrescine, 0 and 19.01 mg/l for cadaverine, respectively. (infowine.com)
  • Employing the probiotic bacteria Pedioccoccus acidilactici MA 18/5M (Bactocell), associated with thorough disinfection and equipment cleaning, which the authors mention brought down the level of biogenic amines contamination in farms, improving feed intake and digestive troubles (diarrheas) and mortality. (allaboutfeed.net)
  • Change in the level of biogenic amines in ischemic heart disease due to qualitatively different carbohydrates]. (semanticscholar.org)
  • The addition of preservatives to foods influences the microbial population dynamics and, consequently, the production of biogenic amines. (asmscience.org)
  • The main mechanism of biogenic formation is the decarboxylation of free amino acids by specific enzymes of microbial origin, which leads to the production of amines. (asmscience.org)
  • The concentration of available free amino acids plays a fundamental role in the formation of amines in foods, in that they are their precursors and, moreover, constitute a substrate for microbial growth. (asmscience.org)
  • 6-8] Besides this, free amino acids are precursors of biogenic amines, other trace compounds important to human health existing in wines. (studyres.com)
  • The simultaneous determination of 17 free amino acids and 8 biogenic amines in Alicante Monastrell wines was investigated for the first time. (upv.es)
  • Biogenic Amines can be found in all foods containing proteins or free amino acids. (supremepeptides.net)
  • MP Biomedicals offers RIA and EIA Test Kits for the in vitro diagnostic (IVD) determination of biogenic amines in human serum, plasma, saliva or urine, as well as Research Use Only (RUO) applications. (mpbio.com)
  • A simple method was developed for the determination of biogenic amines in aquatic food products using a reverse-phase high-performance liquid chromatography with postcolumn automatic o-phthalaldehyde derivatization and fluorescence detection. (unboundmedicine.com)
  • Liquid chromatographic determination of biogenic amines in fermented foods after derivatization with 3,5-dinitrobenzoyl chloride. (semanticscholar.org)
  • Determination of biogenic amines in Korean traditional fermented soybean paste (Doenjang). (semanticscholar.org)
  • Automated derivatization and fluorimetric determination of biogenic amines in milk by zone fluidics coupled to liquid chromatography. (semanticscholar.org)
  • 1993. Liquid chromatographic determination of biogenic amines in dry sausages. (koreascience.or.kr)
  • 2001. Determination of biogenic amines in fresh unpacked and vacuum-packed beef during storage at 4 $^{\circ}$ C. Food Chem. (koreascience.or.kr)
  • Determination of biogenic amines in foods using ultra-performance liquid chromatography (UPLC). (utb.cz)
  • M-FSCV was evaluated with two biogenic amine groups (catecholamines and indolamines) to characterize their inherent adsorption/desorption constants. (rsc.org)
  • 1991. Quantitative changes in bacteria, amino acids and biogenic amines in sardine (Sardina pilchardus) stored at ambient temperature (25-28°C) and in ice. (asmscience.org)
  • For suspected amine sensitivity it seems especially useful to figure out in more detail which foods actually cause symptoms as there are many different types of biogenic amines and one may only be sensitive to certain kinds. (findingmykryptonite.com)
  • Biogenic amines (BAs) are small molecular organic nitrogenous compounds (bases), polar or semipolar. (intechopen.com)
  • However, it is important to state that tea contains less studied bioactive compounds, such as biogenic amines (BAs) which are nonvolatile amines formed by decarboxylation of amino acids. (hindawi.com)
  • Biogenic amines are toxic compounds resulting from the degradation of amino acids in feed by certain microorganisms (enterobacteria, coliforms. (allaboutfeed.net)
  • Biogenic Amine is the basic nitrogenous compounds, which is formed by decarboxylation of amino acids and amination and transamination of the aldehydes and ketones. (supremepeptides.net)
  • A such validated colorimetric detection system is likely to be included in further investigations and clinical studies to support food experts, risk managers and medical doctors in their debate on the potential role of biogenic amines in food intolerance. (donau-uni.ac.at)
  • Ingestion of fermented foods containing high levels of biogenic amines (BA) can be deleterious to human health. (springer.com)
  • This study was performed to examine the levels of biogenic amines (BAs) in foods of animal origin such as egg, ham, sausage, milk, cheese and yoghurt distributed on Korean domestic markets, and to compare the results with those of western countries. (koreascience.or.kr)
  • Effects of biogenic amines on raphe-spinal tract cells. (aspetjournals.org)
  • In this study we have examined the effects of biogenic amines applied iontophoretically in the vicinity of nucleus raphe magnus neurons that project to the spinal cord in monkeys. (aspetjournals.org)
  • CE Analysis of biogenic amines. (ugent.be)
  • Van Hove E, CARNICERO M, Sandra P. CE Analysis of biogenic amines. (ugent.be)
  • This chapter discusses the formation and degradation of biogenic amines, their occurrence in foods, their significance in food safety, their potential use as quality indicators, and the available methods for their determination. (asmscience.org)
  • Biogenic Amine Degradation by Bacillus Species Isolated from Traditional Fermented Soybean Food and Detection of Decarboxylase- Related Genes. (utb.cz)
  • However, very little is known about how the various biogenic amine receptors are integrated into neural networks to potentially drive associations. (frontiersin.org)
  • To determine the protective effect of amines, the rate constant of the reaction of MG with the amino group of N-alpha-acetyl-lysine, carnosine, spermine and spermidine was measured at pH 7.4, and the behavior of endogenous amines was analyzed on the basis of quantum chemical reactivity descriptors. (ub.edu)
  • In the case of other amines such as spermine and spermidine, they yielded very low levels varying between 0 and 2.64 mg/l for spermine, 0 and 3.82 mg/l for spermidine, respectively. (infowine.com)
  • A variety of experimental approaches including genetic, imaging, biochemical and pharmacological analyses have been used to identify the enzymes and cells that make and release the amines and the cells and receptors that bind them. (wormbook.org)
  • Analysis of the phenotypes of such mutants has shed light on the behaviors controlled by the amines and detailed analysis of the expression patterns of the biosynthetic enzymes and transporter has helped identify the cells and neurons in which the neurotransmitters are made and released (see Table 1 ). (wormbook.org)
  • For certain amines the genes and the coded enzymes are demonstrated. (elsevier.com)
  • In humans and other mammals, drugs of abuse alter the function of biogenic amine pathways in the brain leading to the subjective experience of reward and euphoria. (peerj.com)
  • Biogenic amines synthesis in phenylketonuria (PKU) patients with high phenylalanine (Phe) concentration is thought to be impaired due to inhibition of tyrosine and tryptophan hydroxylases and competition with amino acids at the blood-brain barrier. (mpg.de)
  • Biogenic Amine is also the important source of nitrogen and precursor for the synthesis of hormones, alkaloids, nucleic acids, proteins, amines and food aroma components. (supremepeptides.net)
  • Spoilage pattern and biogenic amine formation are species specific. (biomedsearch.com)
  • Three enzyme based amperometric biosensors for biogenic amines were applied for meat spoilage monitoring. (elsevier.com)
  • 1996. Biogenic amine sources in cooked cured shoulder pork. (koreascience.or.kr)
  • 1996. Biogenic amines in dry sausages as affected by starter culture and contaminant amine-positive lactobacillus. (koreascience.or.kr)
  • 1994. Biogenic amines and their production by microorganisms in food. (koreascience.or.kr)
  • The problem of biogenic amines in fermented foods and the use of potential biogenic amine-degrading microorganisms as a solution. (utb.cz)
  • There are many kinds of microorganisms present in the fermented foods because some of them being capable of producing Biogenic Amines. (supremepeptides.net)
  • Seafood may harbor a number of biological, chemical, and physical hazards, the most prevalent of which are biogenic amines (BAs) and biotoxins (chemical), pathogenic bacteria and viruses (biological), and metal inclusion (physical). (frontiersin.org)
  • I forgot, I guess what I mean to ask is, can you get bacteria that go "rogue" and overproduce amine levels where they then produce a pathophysiologic state? (sciencemadness.org)
  • In fact, if lactic acid bacteria are not managed properly, they can lead to problems that include volatile acidity and/or biogenic amine formation. (infowine.com)
  • Scientific opinion on risk based control of biogenic amine formation in fermented foods. (utb.cz)
  • Under this context, we provide an overview over the most widely employed analytical techniques for biogenic amines determination such as chromatographic techniques and biosensors, emphasizing on new approaches. (intechopen.com)
  • In this study, we have developed a microbore high-performance liquid chromatographic method based on precolumn fluorescence derivatization with benzylamine for the determination of the amines in microdialysate from rat brain. (nii.ac.jp)
  • 1997. Biogenic amine and polyamine contents in meat and meat products. (koreascience.or.kr)
  • They also correlate with the amine content of fractions after differential centrifugation of head homogenates. (biologists.org)
  • This study examines the inactivation of the enzyme glucose 6-phosphate dehydrogenase (G6PD) by methylglyoxal (MG) and the eventual protection exerted by endogenous amines. (ub.edu)
  • Biogenic amine transporters: regulation in flux. (nih.gov)
  • Recognition that transmitters, antagonists and second messengers can modify the intrinsic activity, surface expression or protein levels of amine transporters raises new questions about the fundamental nature of drug actions in vivo. (nih.gov)
  • IPC No. U.S. Selective inhibitors of biogenic amine transporters. (rti.org)
  • This study used transfected cells and brain synaptosomes to evaluate the interaction of common biogenic amines with TAAR1 and monoamine autoreceptors and explore their modulatory effects on monoamine transporters. (aspetjournals.org)
  • Biogenic amines are products of the catabolism of all living cell. (sarco.fr)
  • Biogenic amines are molecules resulting from cellular catabolism. (fil-idf.org)
  • Behavioral abnormalities in white , brown and scarlet mutants could arise because aminergic neurons in the Drosophila brain have reduced amine for release. (biologists.org)
  • Common biogenic amines are neurotransmitters in brain that are synthesized and packaged in monoaminergic neurons and released into synaptic clefts to interact with presynaptic and postsynaptic receptors. (aspetjournals.org)
  • This distinguishes cholinergic neurons from those of other biogenic amines where the synaptic signal is terminated by the high‐affinity reuptake of the transmitter. (veteriankey.com)
  • Finally, a variety of drugs that target biogenic amine receptors are available and their effects on behavior can be helpful in determining the physiological roles of the receptors (see Table 3 ). (wormbook.org)
  • Naturally occurring biogenic amines in plants, animals and humans play a crucial role as tissue hormones or neurotransmitters. (demeditec.com)
  • There are interhormone actions between the amines, and between the amines and other hormones produced by Tetrahymena. (elsevier.com)
  • It tries to give answer how and why biogenic amines were selected to hormones, and why new functions formed for them in higher ranked animals, preserving also the ancient ones. (elsevier.com)
  • The beneficial effects of fish consumption on human health such as protection against coronary heart disease and certain cancer may be offset by fish decomposition and the formation of chemical contaminants such as biogenic amines. (biomedsearch.com)
  • HP seems to be effective for reducing the formation of biogenic amines in this kind of product. (biomedsearch.com)
  • Improper handling and storage conditions contribute to the formation of biogenic amines and as humans, our noses are unable to detect the beginning stages of rancidity as animals often can. (trilogylab.com)
  • on biogenic amine formation during the ripening of dry fermented sausages. (koreascience.or.kr)
  • Recent findings indicate that amine reuptake is likely to be a tightly regulated component of synaptic plasticity rather than a constitutive determinant of transmitter clearance. (nih.gov)
  • Biogenic amines modulate a variety of C. elegans behaviors including locomotion, egg laying (see Egg laying ), defecation, and foraging. (wormbook.org)
  • These data provide the first evidence that common biogenic amines modulate monoamine transporter function via both TAAR1 and monoamine autoreceptors, which may balance monoaminergic activity. (aspetjournals.org)
  • suggests that common biogenic amines may modulate monoamine transporter function via interacting with monoamine autoreceptors in the brain. (aspetjournals.org)
  • Therefore, biogenic amines monitoring in food samples is a matter of utmost importance, and their accurate determination is considered indispensable. (intechopen.com)
  • 666 31.1.2 Relevance of Biogenic Amines in Food. (taylorfrancis.com)
  • In the food industry, biogenic amines are of bacterial origin. (sarco.fr)
  • The amount of CO2 from decarboxylating amino acids at the levels needed to produce biologically significant levels of amines would not be very important or likely detectable, especially as the CO2 has to diffuse from the gut to the bloodstream and is being produced by other bacterial processes. (sciencemadness.org)
  • This indicates that biogenic amine contents in Chunjang are primarily attributed to bacterial abilities to produce biogenic amines. (nih.gov)