Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Receptors, Biogenic Amine: Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Biogenic Monoamines: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.Polyphloretin Phosphate: A polymeric mixture of polyesters of phosphoric acid and phloretin. It blocks some cellular responses to prostaglandins.Amine Oxidase (Copper-Containing): A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.Vesicular Biogenic Amine Transport Proteins: Integral membrane proteins of the LIPID BILAYER of SECRETORY VESICLES that catalyze transport and storage of biogenic amine NEUROTRANSMITTERS such as ACETYLCHOLINE; SEROTONIN; MELATONIN; HISTAMINE; and CATECHOLAMINES. The transporters exchange vesicular protons for cytoplasmic neurotransmitters.Norepinephrine Plasma Membrane Transport Proteins: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.Lactobacillales: An order of gram-positive bacteria in the class Bacilli, that have the ability to ferment sugars to lactic acid. They are widespread in nature and commonly used to produce fermented foods.KynuramineDopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Monoamine Oxidase: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Tyrosine Decarboxylase: A pyridoxal-phosphate protein that catalyzes the conversion of L-tyrosine to tyramine and carbon dioxide. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine. (From Enzyme Nomenclature, 1992) EC 4.1.1.25.Chromatography, Micellar Electrokinetic Capillary: A hybrid separation technique combining both chromatographic and electrophoretic separation principles. While the method was invented to separate neutral species, it can also be applied to charged molecules such as small peptides.Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.Hydroxyindoleacetic AcidNorepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Metiamide: A histamine H2 receptor antagonist that is used as an anti-ulcer agent.Methallibure: A dithiobiurea compound with anti-gonadotropic activity.Biogenic Polyamines: Biogenic amines having more than one amine group. These are long-chain aliphatic compounds that contain multiple amino and/or imino groups. Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA.Salsoline Alkaloids: Tetrahydroisoquinolinol alkaloids in both dextro and levo forms, originally found in SALSOLA plants.Serotonin Plasma Membrane Transport Proteins: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.Phenylacetates: Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.Methylhistamines: Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.Phenethylamines: A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)Neurotransmitter Agents: Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.Lactobacillus brevis: A species of gram-positive, rod-shaped LACTIC ACID bacteria that is frequently used as starter culture in SILAGE fermentation, sourdough, and lactic-acid-fermented types of beer and wine.Synephrine: Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.Dopamine Plasma Membrane Transport Proteins: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.Decarboxylation: The removal of a carboxyl group, usually in the form of carbon dioxide, from a chemical compound.Saguinus: A genus in the subfamily CALLITRICHINAE consisting of 12 species and found in Panama as well as South America. Species seen most frequently in the literature are S. oedipus (cotton-top marmoset), S. nigricollis, and S. fusicollis.Methyltyrosines: A group of compounds that are methyl derivatives of the amino acid TYROSINE.Catecholamines: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.Putrescine: A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Monoamine Oxidase Inhibitors: A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.Lysergic Acid Diethylamide: Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Wine: Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.Food Preservation: Procedures or techniques used to keep food from spoiling.Phenelzine: One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.Cheese: A nutritious food consisting primarily of the curd or the semisolid substance formed when milk coagulates.Malpighian Tubules: Slender tubular or hairlike excretory structures found in insects. They emerge from the alimentary canal between the mesenteron (midgut) and the proctodeum (hindgut).Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.Membrane Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.Equilibrative Nucleoside Transport Proteins: A class of sodium-independent nucleoside transporters that mediate the facilitative transport of NUCLEOSIDES.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

Agonistic behaviour and biogenic amines in shore crabs Carcinus maenas. (1/250)

To investigate the role of certain neurohormones in agonistic behaviour, fights were staged between pairs of size-matched male shore crabs Carcinus maenas, and blood samples were taken immediately after the contests had been resolved. Samples were also taken from these crabs at rest (before and after fighting) and after walking on a treadmill. A control group of crabs also had samples taken on each experimental day. Concentrations of tyramine, dopamine, octopamine, serotonin (5-HT) and norepinephrine were determined in each blood sample using a gas chromatography/mass spectrometry (GC-MS) system. Norepinephrine was not detectable in any of the samples, but the standards were recovered. Tyramine values were not significantly different between the control group and the fought group, so tyramine does not appear to be important in agonistic behaviour. A comparison between the control and fought groups shows that fighting had an effect on the concentrations of octopamine, dopamine and 5-HT, but exercise only had an effect on octopamine levels, which showed a reduction from resting values in both winners and losers. Resting and post-fight concentrations of octopamine, dopamine and 5-HT were higher in winners than in losers. 5-HT concentration increased in the blood of fought crabs from resting values, whereas dopamine concentration decreased. In winners, octopamine concentrations decreased from resting values, but in losers octopamine levels increased from resting concentrations. The escalatory behaviour or intensity of fighting performed by winners and losers was related to dopamine levels but not to those of octopamine or 5-HT. Therefore, there appears to be a link between relative concentrations of these three amines (dopamine, octopamine and 5-HT) and fighting ability; the effects are not simply a result of activity. The better competitors have higher concentrations of these three amines at rest and after fighting.  (+info)

Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex. (2/250)

5-Hydroxytryptamine (5-HT) plays a role in the regulation of 3, 4-dihydroxyphenylethylamine (dopamine) neurons in the brain, but the precise mechanism of regulation by 5-HT(1A) receptors of dopamine release has not been defined. The present study describes the effect of 5- inverted question mark3-[[(2S)-1,4-benzodioxan-2ylmethyl]amino]propoxy inverted question mark-1, 3-benzodioxole HCl (MKC-242), a highly potent and selective 5-HT(1A) receptor agonist, on dopamine release in the prefrontal cortex using microdialysis in the freely moving rat. Subcutaneous injection of MKC-242 (0.3 - 1.0 mg kg(-1)) increased extracellular levels of dopamine in the prefrontal cortex. The effect of MKC-242 in the prefrontal cortex was antagonized by pretreatment with the selective 5-HT(1A) receptor antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohe xanecarboxamide (WAY100635; 1 mg kg(-1), i.p.). Local application of WAY100635 (10 microM) via a microdialysis probe antagonized the effect of systemic MKC-242 in an increasing dopamine release, and locally infused 8-hydroxy-2-(di-n-propylamino)tetralin (10 microM) increased dopamine release in the prefrontal cortex. MKC-242 increased cortical dopamine release in the rats pretreated with 5, 7-dihydroxytryptamine (150 microgram, i.c.v.) that caused an almost complete reduction in cortical 5-HT content. The effect of MKC-242 to increase dopamine release was also observed in the hippocampus, but not in the striatum or nucleus accumbens. Fluoxetine, a selective serotonin reuptake inhibitor, increased dopamine release in the prefrontal cortex, but not in the nucleus accumbens, while buspirone, a 5-HT(1A) receptor agonist, increased dopamine release in both brain regions. The present results indicate that activation of postsynaptic 5-HT(1A) receptors increases dopamine release in a brain region-specific manner.  (+info)

Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. (3/250)

Presynaptic transporter proteins regulate the clearance of extracellular biogenic amines after release and are important targets for multiple psychoactive agents, including amphetamines, cocaine, and antidepressant drugs. Recent studies reveal that dopamine (DA), norepinephrine (NE), and serotonin (5-HT) transporters (DAT, NET, and SERT, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase C (PKC). With SERTs, PKC activation results in activity-dependent transporter phosphorylation and sequestration. Protein phosphatase 1/2A (PP1/PP2A) inhibitors, such as okadaic acid (OA) and calyculin A, also promote SERT phosphorylation and functional downregulation. How kinase, phosphatase, and transporter activities are linked mechanistically is unclear. In the present study, we found that okadaic acid-sensitive phosphatase activity is enriched in SERT immunoprecipitates from human SERT stably transfected cells. Moreover, blots of these immunoprecipitates reveal the presence of PP2A catalytic subunit (PP2Ac), findings replicated using brain preparations. Whole-cell treatments with okadaic acid or calyculin A diminished SERT/PP2Ac associations. Phorbol esters, which trigger SERT phosphorylation, also diminish SERT/PP2Ac associations, effects that can be blocked by PKC antagonists as well as the SERT substrate 5-HT. Similar transporter/PP2Ac complexes were also observed in coimmunoprecipitation studies with NETs and DATs. Our findings provide evidence for the existence of regulated heteromeric assemblies involving biogenic amine transporters and PP2A and suggest that the dynamic stability of these complexes may govern transporter phosphorylation and sequestration.  (+info)

Neurochemical and metabolic aspects of antidepressants: an overview. (4/250)

Antidepressants, in addition to being effective therapeutic agents for depression, have also proved to be multifaceted drugs useful for treating a number of other psychiatric and neurologic disorders. Despite the widespread use of these drugs, much remains to be understood about their mechanisms of action and other important aspects, such as their metabolism and potential interactions with other drugs. This article reviews research conducted in the authors' laboratories on various aspects of antidepressants, including trace amines and antidepressants, gamma-aminobutyric acid and antidepressants, drug metabolism, development and application of rapid, sensitive assay procedures for antidepressants and their metabolites; and drug development based on analogues of the antidepressants phenelzine and tranylcypromine. The significance of this work to future drug development is also discussed.  (+info)

Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. (5/250)

Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two-step mechanism: Na(+)-K(+)-ATPase-energized basolateral active extrusion of sodium permits passive apical entry through various sodium transport systems. In the past 15 years, most of the renal sodium transport systems (Na(+)-K(+)-ATPase, channels, cotransporters, and exchangers) have been characterized at a molecular level. Coupled to the methods developed during the 1965-1985 decades to circumvent kidney heterogeneity and analyze sodium transport at the level of single nephron segments, cloning of the transporters allowed us to move our understanding of hormone regulation of sodium transport from a cellular to a molecular level. The main purpose of this review is to analyze how molecular events at the transporter level account for the physiological changes in tubular handling of sodium promoted by hormones. In recent years, it also became obvious that intracellular signaling pathways interacted with each other, leading to synergisms or antagonisms. A second aim of this review is therefore to analyze the integrated network of signaling pathways underlying hormone action. Given the central role of Na(+)-K(+)-ATPase in sodium reabsorption, the first part of this review focuses on its structural and functional properties, with a special mention of the specificity of Na(+)-K(+)-ATPase expressed in renal tubule. In a second part, the general mechanisms of hormone signaling are briefly introduced before a more detailed discussion of the nephron segment-specific expression of hormone receptors and signaling pathways. The three following parts integrate the molecular and physiological aspects of the hormonal regulation of sodium transport processes in three nephron segments: the proximal tubule, the thick ascending limb of Henle's loop, and the collecting duct.  (+info)

A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake. (6/250)

A human midgut carcinoid tumor was successfully transplanted into nude mice and propagated for five consecutive generations (30 months) with well-preserved phenotype. Tumor cells in nude mice expressed identical neuroendocrine markers as the original tumor, including somatostatin receptors (somatostatin receptors 1 to 5) and vesicular monoamine transporters (VMAT1 and VMAT2). Because of the expression of somatostatin receptors and VMAT1 and VMAT2 the grafted tumors could be visualized scintigraphically using the somatostatin analogue 111In-octreotide and the catecholamine analogue 123I-metaiodobenzylguanidine. The biokinetics of the somatostatin analogue 111In-octreotide in the tumors was studied and showed a high retention 7 days after administration. Cell cultures were re-established from transplanted tumors. Immunocytochemical and ultrastructural studies confirmed the neuroendocrine differentiation. The human origin of transplanted tumor cells was confirmed by cytogenetic and fluorescence it situ hybridization analyses. Spontaneous secretion of serotonin and its metabolite, 5-hydroxyindole acetic acid, from tumor cells was demonstrated. The tumor cells increased their [Ca2+]i in response to beta-adrenoceptor stimulation (isoproterenol) and K+-depolarization. All somatostatin receptor subtypes could be demonstrated in cultured cells. This human transplantable carcinoid tumor, designated GOT1, grafted to nude mice, will give unique possibilities for studies of somatostatin receptor- and VMAT-mediated radionuclide uptake as well as for studies of secretory mechanisms.  (+info)

Biogenic amines in Drosophila virilis under stress conditions. (7/250)

The effect of heat stress (38 degrees C) on the content of DL-beta-(3,4-dihydroxyphenyl)alanine (DOPA), dopamine, tyramine, octopamine, and their precursor Tyr was studied in adults of two lines of Drosophila virilis contrasting in their stress response. In individuals of line 101 responding to stress by a hormonal stress reaction, the contents of DOPA, dopamine, octopamine, and Tyr were lower than those of line 147 that did not respond to the stress. However, heat stress caused an increase in the contents of DOPA, dopamine, octopamine, and Tyr in line 101, whereas the equivalent titers in line 147 remain unchanged.  (+info)

Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [3H]imipramine reuptake in the primary fibromyalgia syndrome. (8/250)

BACKGROUND: Primary fibromyalgia syndrome (PFS) is a chronic disorder commonly seen in rheumatological practice. The pathophysiological disturbances of this syndrome, which was defined by the American College of Rheumatology in 1990, are poorly understood. This study evaluated, in 30 patients, the hypothesis that PFS is a pain modulation disorder induced by deregulation of serotonin metabolism. OBJECTIVES: To compare platelet [(3)H]imipramine binding sites and serotonin (5-HT) levels in plasma-rich platelets (PRP) of PFS patients with those of matched healthy controls and to compare the levels of biogenic amine metabolites in the cerebrospinal fluid (CSF) of PFS patients with those of matched controls. METHODS: Platelet [(3)H]imipramine binding sites were defined by two criteria, B(max) for their density and K(d) for their affinity. PRP 5-HT and CSF metabolites of 5-HT (5-hydroxyindoleacetic acid, 5-HIAA), norepinephrine (3-methoxy, 4-hydroxy phenylglycol, MHPG) and dopamine (homovanillic acid, HVA) were assayed by reversed-phase high-performance liquid chromatography with coulometric detection. RESULTS: [(3)H]Imipramine platelet binding was similar (P=0.43 for B(max) and P=0.30 for K(d)) in PFS patients (B(max)=901+/-83 fmol/mg protein, K(d)=0.682+/-0.046) and in matched controls (B(max)=1017+/-119 fmol/mg protein, K(d)=0.606+/-0.056). PRP 5-HT was significantly higher (P=0.0009) in PFS patients (955+/-101 ng/10(9) platelets) than in controls (633+/-50 ng/10(9) platelets). When adjusted for age, the levels of all CSF metabolites were lower in PFS patients. The CSF metabolite of norepinephrine (MHPG) was lower (P:=0.003) in PFS patients (8.33+/-0.33 ng/ml) than in matched controls (9.89+/-0.31 ng/ml) and 5-HIAA was lower (P=0.042) in PFS female patients (22.34+/-1.78 ng/ml) than in matched controls (25.75+/-1.75 ng/ml). For HVA in females, the difference between PFS patients (36.32+/-3.20 ng/ml) and matched controls (38.32+/-2.90 ng/ml) approached statistical significance (P=0.054). CONCLUSION: Changes in metabolites of CSF biogenic amines appear to be partially correlated to age but remained diagnosis-dependent. High levels of PRP 5-HT in PFS patients were associated with low CSF 5-HIAA levels in female patients but were not accompanied by any change in serotonergic uptake as assessed by platelet [(3)H]imipramine binding sites. These findings do not allow us to confirm that serotonin metabolism is deregulated in PFS patients.  (+info)

TY - JOUR. T1 - Brain Biogenic Amine Depletion and Mood. AU - Mendels, Joseph. AU - Frazer, Alan. PY - 1974/4. Y1 - 1974/4. N2 - To evaluate the hypothesis that clinical depression is associated with reduced brain biogenic amine activity, the behavioral effects, in man, of drugs that deplete the brain of biogenic amines were reviewed. The behavioral changes associated with reserpine administration were interpreted as being primarily a psychomotor retardation-sedation syndrome, due perhaps to a dopamine deficiency, and would not be an adequate model for clinical depression. In susceptible persons, particularly those with a prior history of depression, this psychomotor retardation-sedation might be sufficient to trigger a depression-like episode. More selective amine depletion, produced either by alpha-methyl-paratyrosine or by parachlorophenylalanine is not associated with depression. Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that ...
TY - JOUR. T1 - Brain biogenic amine levels after methanol administration. T2 - Possible mechanism of action of central monoaminergic neurons in discrete areas of brain in Wistar rats. AU - Jeganathan, P. S.. AU - Namasivayam, A.. PY - 1989/1/1. Y1 - 1989/1/1. UR - http://www.scopus.com/inward/record.url?scp=0024396801&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024396801&partnerID=8YFLogxK. M3 - Article. C2 - 2592039. AN - SCOPUS:0024396801. VL - 33. SP - 151. EP - 156. JO - Indian Journal of Physiology and Pharmacology. JF - Indian Journal of Physiology and Pharmacology. SN - 0019-5499. IS - 3. ER - ...
en fr Study of biogenic amines metabolism in wine lactic acid bacteria Etude du métabolisme des amines biogènes chez les bactéries lactiques du vin . . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Spoilage Detection with Biogenic Amine Biosensors, Comparison of Different Enzyme Electrodes. AU - Bóka, Beáta. AU - Adányi, N.. AU - Virág, Diána. AU - Sebela, Marek. AU - Kiss, Attila. PY - 2012/1. Y1 - 2012/1. N2 - Three enzyme based amperometric biosensors for biogenic amines were applied for meat spoilage monitoring. With diamine oxidase (EC 1.4.3.6), the total biogenic amine content was measured. Monoamine oxidase A (EC 1.4.3.4) was used for determination of tyramine, tryptamine and phenylethylamine content. Putrescine was selectively detected with putrescine oxidase (EC 1.4.3.10). The enzymes were separately co-immobilized on graphite electrodes with peroxidase and Os mediator (PVI7-dme-Os). A fast extraction method using special centrifugal separator was applied for pork and fish samples stored at different conditions. Although partial extraction was achieved, the results correlate with total biogenic amine content measured by HPLC method.. AB - Three enzyme based ...
Abstract (EN): The presence of biogenic amines in foodstuffs is an important food safety problem because of the implication of these compounds in food intolerance and intoxication. The separation and quantification of biogenic amines in foods is normally performed by chromatographic techniques. This review contains descriptions of the quantification of biogenic amines in Portuguese traditional fermented and/or ripened foods and wines, including Protected Denomination of Origin cheeses, drycured sausages, and Portuguese wines (including Port wines), using different analytical methods based on high-pressure liquid chromatography (UV or diode array and/or fluorometric detectors) and gas chromatography (with a mass spectrometry detector). The evolution of biogenic amines during fermentation, ripening, aging, or storage of those products was also evaluated. Biogenic amine concentrations ranged widely within individual food items, and storage, transport, and handling conditions can influence to some ...
Definition of biogenic amine hypothesis in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is biogenic amine hypothesis? Meaning of biogenic amine hypothesis as a legal term. What does biogenic amine hypothesis mean in law?
Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary ... read more tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean=0, SD=1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios ...
In this study, the quantitative determination of eight biogenic amines (cadaverine, serotonin, histamine, spermidine, spermine, tyramine, putrescine and β-phenylethylamine) by an liquid chromatography method with evaporative light scattering detection was performed. The analysis of several samples of conventional, organic and fair trade cocoa-derivatives showed that organic and fair trade samples always contain much lower amine concentrations in comparison with their conventional counterparts, supporting the idea that biogenic amines can be regarded as cocoa quality markers. Irrespective of the kind of sample, results also showed that the most abundant amines were histamine, tyramine, spermidine, putrescine and spermine while β-phenylethylamine, cadaverine and serotonine have been found more rarely, all the amines never reaching dangerous amounts for consumer health. With the aim to confirm the experimental results, clustering analysis was performed on samples and instrumental results using principal
Biogenic amines (BAs) are organic amines present in meat, fish, dairy produce and wine due to the breakdown of amino acids, catalysed by microbial decarboxylases. BAs determination in food is important not only because of possible toxicological effects such as nausea, sweating and headache but also due to their possible role as indicators of food spoilage. Chromatographic methods are traditionally applied for determination of BAs in food [1], which usually require preliminary operations for sample pre-treatment that are laborious and difficult to automate. On the other hand, screening analytical systems provide simple, low cost and rapid analysis with the possibility of subjecting high number of samples to the screening system in a short time [2]. In this work we present a novel method for screening determination of BAs using a microfluidic system with the detection by highly sensitive thermal lens microscope (μFIA-TLM). Four biogenic amines (putrescine, cadaverine, histamine and tyramine) were ...
Autism spectrum disorders (ASD) constitute a complex, heterogeneous, multifactorial group of neurodevelopmental conditions characterized by impairment of social interactions, communication issues and repetitive behaviors. The heterogeneity of ASD is emerging as a dominant theme and poses a complex challenge in developing new treatments as well as biomarkers. Although there are umpteen biomarkers identified in relation to ASD, abnormalities in biogenic amines from the tryptophan metabolism pathway have been more commonly implicated in ASD. This review is a compilation of the reports on peripheral alterations of the biogenic amines of the tryptophan pathway in ASD. Based on the literature search of previous studies, whole blood serotonin may be considered as a diagnostic marker as well as a genetic vulnerability factor for this disease. The one-time "after sleep offset" measurement of plasma melatonin seems to be a sensitive, practical, feasible and convenient measurable parameter in the clinical ...
As noted in the Introduction, BAT ligands are classically divided into uptake inhibitors and releasers. Releasers are BAT substrates, and the inward transport of a BAT substrate, together with Na+ and Cl−, leads to the countertransport of endogenous neurotransmitter out of the nerve terminal. Resolution of the structure of the bacterial LeuTAa transporter (Yamashita et al., 2005; Shi et al., 2008) identified two substrate binding sites (S1 and S2), suggesting that the BATs might also possess two substrate binding sites, where the binding of a substrate to S2 triggers the release of substrate bound to S1 and Na+ into the intracellular compartment (Nyola et al., 2010; Schmitt et al., 2010). These findings emphasize the importance of conformational changes to transporter function (Ferrer and Javitch, 1998; Reith et al., 2001; Gether et al., 2006) and raise the possibility that the actions of the two BAT binding sites might differ. Data in the literature support this idea. For example, Goodwin et ...
Wines, specifically those in which lactic acid bacteria can grow can cause transient toxic effects due to the formation of biogenic amines such as histamine and tyramine. Some people specifically avoid red wines because they are more often associated with headaches and other discomforts. An understanding of the origin, occurrence and formation of amines in grape and berry wines will lead to developing approaches to preventing their formation ...
Twenty Apulian and Sicilian cheeses were analysed for their concentrations of eight biogenic amines (BAs), free amino acids, pH, water activity, and subjected to microbiological characterisation. In addition, lactic acid bacteria isolated from cheeses were assayed for their capacity to generate BAs. Principal component analysis was performed to find the effect of different parameters on the distribution of the cheeses. Although short-ripened (<= 30 d) cheeses did not show significant BA concentrations, the only BA showing high positive correlation with time of ripening was histamine. Concentration of histidine and, especially, percentage of histidine-decarboxylase bacteria presumably affected histamine concentration. High pH values were negatively correlated to the concentration of tyramine, putrescine, and cadaverine. Fifty percent of the cheeses contained at least one BA at potentially toxic concentrations. Unambiguous and ever-valid relations among parameters and BAs are difficult to ...
Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine. It has been sold online as a designer drug. It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively. Methamnetamine is illegal in Japan. Naphthylaminopropane HDEP-28 HDMP-28 Naphyrone WF-23 Richard B. Rothman; John S. Partilla; Michael H. Baumann; Catrissa Lightfoot-Siordia; Bruce E. Blough (April 2012). "Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy "Partial" Substrates for the Biogenic Amine Transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251-262. doi:10.1124/jpet.111.188946. PMC 3364510 . PMID 22271821. "Methamnetamine". WEDINOS. "Methamnetamine". New Synthetic Drugs Database. ...
A large number of biogenic amines ELISA kits are available, these organic bases are formed by decarboxylation of amino acids or by transamination of aldehydes
biogenic amine: a biologically synthesized substance, fundamentally a nitrogen compound, widely dispersed in the body. Some hormones, such as adrenaline...
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Build confidence in your biogenic amine analysis by relying on the durability offered by Enzyme immunoassays (EIAs) and Radio immunoassays (RIAs).
Biogenic amine은 주로 단백질을 함유한 식품이 미생물 에 의해 분해되는 과정에서 생성되는 비휘발성 아민으로 어류나 갑각류의 사후에 생성되는 물질들이다. 여기에는 cataverine, putrescine, spermidine, spermine, tyramine, trytamine 및 histamine 등이 속해있다. 이들은 어류나 갑 각류의 조직에 함유된 특정 유리아미노산의 탈탄산 (decarboxylation) 반응에 의해 생성되는 것으로 알려져 있 다. 어류를 장시간 보관할 경우 어류에 있는 미생물에 의 해 유리아미노산이 biogenic amines으로 전환되어 이것을 섭취한 사람이 특이증세를 나타내게 된다. 식품 중에 낮 은 수준의 biogenic amines이 함유되어 있을 경우에는 섭 취 시에도 큰 문제가 일어나지 않지만 과량 섭취하였을 경우에는 아민의 이화작용이 저해되어 저혈압, 고혈압, 메 스꺼움, 구토, 발진 및 심계항진과 같은 생리적 증세를 나 ...
Withdrawal reactions are an important and well-recognised side effect of Seroxat and also occur with the other SSRIs. The MCA/CSM warned prescribers about the possibility of withdrawal reactions associated with Seroxat via an article in the Bulletin, XCurrent Problems in Pharmacovigilance" in 1993. The CSM re-reviewed the issue of withdrawal reactions and possible dependence with Seroxat and the other SSRIs in 1998 99. From a detailed review of all available data, 5 Nov 2002 : Column 272W. the CSM concluded that all SSRIs may be associated with withdrawal reactions on stopping, but that on current evidence, they are not associated with dependence. As a result of this review, product information for all SSRIs was updated in relation to withdrawal reactions. This issue was also reviewed at a European level by the Committee on Proprietary Medicinal Products (CPMP), which reached similar conclusions. ...
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The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
Materials. Dopamine, norepinephrine, serotonin, indatraline, methylphenidate, desipramine, citalopram, raclopride, SKF86466, and methiothepin were purchased from Sigma-Aldrich (St. Louis, MO). Dulbeccos modified Eagles medium (DMEM), 100× nonessential amino acids, fetal bovine serum, 100× penicillin/streptomycin, Geneticin (G418), and trypsin/EDTA were purchased from Invitro-gen (Carlsbad, CA). Dual-Luciferase Reporter Assay System kit, pGL4.73, and Passive Lysis Buffer (5×) were obtained from Promega (Madison, WI). [3H]Dopamine (60 Ci/mmol), [3H]norepinephrine (49.5 Ci/mmol), and [3H]serotonin (20.3 Ci/mmol) were purchased from PerkinElmer Life and Analytical Sciences (Boston, MA). ReadySafe cocktail was obtained from Beckman Coulter (Fullerton, CA). The expression constructs of human α2A, α2B, 5-HT1A, and 5-HT1B were purchased from UMR cDNA Resource Center (Rolla, MO). Rhesus monkey dopamine D2 receptor short isoform (D2s) was constructed in pcDNA3.1(+) in our laboratory.. Cell Culture ...
In vertebrates, biogenic amines such as dopamine, serotonin, epinephrine and norepinephrine act physiologically as neurotransmitters, neuromodulators and neurohormones to regulate many important processes. In contrast, norepinephrine and epinephrine do not appear to be present in insects, as they lack dopamine β-hydroxylase that converts dopamine to norepinephrine. In fact, their role is fulfilled by their invertebrate counterparts, the monoamines tyramine and octopamine. The insect biogenic amines carry out many of the physiological roles such as reproduction, development, growth, circadian rhythms, endocrine secretion, and behaviors. They exert their effects by binding to specific receptor proteins that belong to the superfamily of G-protein coupled receptors (GPCRs), many of which have been characterized not only from Drosophila but also from several other insect species. Thus, blocking or over stimulating these GPCRs in pest insects may either result in the death or reduce fitness to ...
In an attempt to study the effects of several substances on intracellular cyclic adenosine 3′:5′-monophosphate (cAMP) concentration in tumor cells, lymphoma cells were incubated with biogenic amines (histamine, norepinephrine, epinephrine, and isoproterenol), prostaglandin E1 (PGE1), and Vinca alkaloids (vincristine and vinblastine). All substances tested increased intracellular cAMP in the presence of theophylline. Combined administration of Vinca alkaloid with biogenic amines or PGE1 produced an additive increase of cAMP in lymphoma cells. Vinca alkaloids depressed cAMP phosphodiesterase activity, but this depression was too weak to explain an increase of cAMP. In lymphoma cell homogenate, biogenic amines and PGE1 increased cAMP but Vinca alkaloids failed to do so, suggesting destruction of the receptor and/or transducer mechanism for Vinca alkaloids by homogenization. The effect of biogenic amines, PGE1, and Vinca alkaloids on cAMP was depressed by pretreatment of lymphoma cells with ...
Bacterial vaginosis (BV) is the most common vaginal disorder among reproductive age women. One clinical indicator of BV is a fishy odor. This odor has been associated with increases in several biogenic amines (BAs) that may serve as important biomarkers. Within the vagina, BA production has been linked to various vaginal taxa, yet their genetic capability to synthesize BAs is unknown. Using a bioinformatics approach, we show that relatively few vaginal taxa are predicted to be capable of producing BAs. Many of these taxa (Dialister, Prevotella, Parvimonas, Megasphaera, Peptostreptococcus, and Veillonella spp.) are more abundant in the vaginal microbial community state type (CST) IV, which is depleted in lactobacilli. Several of the major Lactobacillus species (L. crispatus, L. jensenii, and L. gasseri) were identified as possessing gene sequences for proteins predicted to be capable of putrescine production. Finally, we show in a small cross sectional study of 37 women that the BAs putrescine,
Ingestion of fermented foods containing high levels of biogenic amines (BA) can be deleterious to human health. Less obvious is the threat posed by BA producing organisms contained within the food whi
The trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine neurotransmitters. It is currently thought that the biological activities elicited by trace amines such as p-tyramine and the psychostimulant amphetamines are manifestations of their ability to inhibit the clearance of extracellular transmitter and/or stimulate the efflux of transmitter from intracellular stores. Here we report the discovery and pharmacological characterization of a rat G protein-coupled receptor that stimulates the production of cAMP when exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine. An extensive pharmacological survey revealed that psychostimulant and hallucinogenic amphetamines, numerous ergoline derivatives, adrenergic ligands, and 3-methylated metabolites of the catecholamine neurotransmitters are also good agonists at the rat trace amine receptor 1 (rTAR1). These results suggest that the trace amines and catecholamine ...
A Perspective on Biogenic Reefs and SACs The distribution of major examples of biogenic reefs is given by species in Table 3 and Figure 2, both within cSACs and pSACs, and elsewhere. No currently proposed SACs were selected specifically on the basis that they contain biogenic reefs. However, biogenic reefs are sub-features of other Annex I features such as reefs , estuaries or large shallow inlets and bays . In some cases biogenic reefs are specifically mentioned as reasons why a site is a particularly good example of an Annex 1 habitat e.g. Mytilus in Morecambe Bay, Modiolus in Strangford Lough, Lleyn Peninsula and the Sarnau and Loch Maddy; Sabellaria alveolata in the Solway Firth and Morecambe Bay. There are candidate SACs selected on the basis of the presence of reefs which do have substantial areas of Modiolus reef (Lochs Duich, Long and Alsh, Lleyn Peninsula and the Sarnau), Sabellaria alveolata reef (Lleyn Peninsula and the Sarnau); and probably Sabellaria spinulosa reef (Lleyn Peninsula ...
Looking for online definition of biogenic in the Medical Dictionary? biogenic explanation free. What is biogenic? Meaning of biogenic medical term. What does biogenic mean?
Objective: To evaluate the activities of Na+,K+-ATPase and Mg2+-ATPase in erythrocyte membranes from phenylketonuric (PKU) patients and to correlate the enzyme activities with their blood phenylalanine (Phe) levels, biogenic amines as well as with their precursors tyrosine (Tyr) and tryptophan (Try). Design and methods: Twenty three PKU patients were divided into group A (n = 12) on a stricted diet (Phe 1.57 ± 0.52 mg/dL or 0.10 ± 0.03 mM) and group B (n = 11) on a "loose" diet (Phe 24.45 ± 1.50 mg/dL or 1.72 ± 0.09 mM). The enzyme activities were measured spectrophotometrically, the amino acids with an automatic amino analyser and the biogenic amines with HPLC methods. Results: In group B, plasma amino acids (Tyr, Try), their biogenic amines [adrenaline (A), noradrenaline (NA), dopamine (DA) and serotonin (5HT)], (Na+,K+)-ATPase and Mg2+-ATPase activities were found remarkably decreased (p , 0.001). Conclusions: High Phe and/or low NA, DA, 5HT plasma levels may indirectly inhibit the ...
Polyamines and biogenic amines are chemicals derived from amino acids. Polyamines are involved in intracellular signals. Biogenic amines function in intercellular communication. Epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) targets the pathways of biogenic amines and polyamines. This is of therapeutic interest in treating cancer. Tea is, also, a source of the amino acid, theanine, […]. View Post ...
The purpose of this study was to elucidate the characteristics and mechanisms of adsorption and desorption for heavy metals by micro and nano-sized biogenic CaCO3 induced by Bacillus subtilis, and the pH effect on adsorption was investigated. The results showed that the adsorption characteristics of Cd2+ and Pb2+ are well described by the Langmuir adsorption isothermal equation, and the maximum adsorption amounts for Cd2+ and Pb2+ were 94.340 and 416.667 mg/g, respectively. The maximum removal efficiencies were 97% for Cd2+, 100% for Pb2+, and the desorption rate was less than 3%. Further experiments indicated that the biogenic CaCO3 could maintain its high adsorption capability for heavy metals within wide pH ranges (3-8). The FTIR and XRD results showed that, after the biogenic CaCO3 adsorbed Cd2+ or Pb2+, it did not produce a new phase, which indicated that biogenic CaCO3 and heavy metal ions are governed by a physical adsorption process, and the high adsorptive capacity of biogenic CaCO3 for Cd2+
Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists - and hence, monoaminergic neuromodulators - that are structurally and metabolically related to classical monoamine neurotransmitters. Compared to the classical monoamines, they are present in trace concentrations. They are distributed heterogeneously throughout the mammalian brain and peripheral nervous tissues and exhibit high rates of metabolism. Although they can be synthesized within parent monoamine neurotransmitter systems, there is evidence that suggests that some of them may comprise their own independent neurotransmitter systems. Trace amines play significant roles in regulating the quantity of monoamine neurotransmitters in the synaptic cleft of monoamine neurons with co-localized TAAR1. They have well-characterized presynaptic amphetamine-like effects on these monoamine neurons via TAAR1 activation; specifically, by activating TAAR1 in neurons they promote the release and prevent reuptake of ...
Biogenic amine transporters play important roles in the action and recycling of their specific neurotransmitter substrates. They have been well established as t...
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.
The Blakely Lab explores the molecular basis for neurotransmitter transporter structure, function and regulation. Chimera, site-directed mutagenesis and site-specific chmical modification strategies are used to explore the topology and quaternary structure of biogenic amine transporters. The lab evaluates what molecules control the proper localization and activity of transporter proteins using genetic (C. elegans) and molecular biologic methods. The Blakely Lab is also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters, and confer increased risk for autonomic, neurologic and mental disorders. For additional information, visit the Blakely Lab Website.  
The Blakely Lab explores the molecular basis for neurotransmitter transporter structure, function and regulation. Chimera, site-directed mutagenesis and site-specific chmical modification strategies are used to explore the topology and quaternary structure of biogenic amine transporters. The lab evaluates what molecules control the proper localization and activity of transporter proteins using genetic (C. elegans) and molecular biologic methods. The Blakely Lab is also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters, and confer increased risk for autonomic, neurologic and mental disorders. For additional information, visit the Blakely Lab Website.  
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Conventional supported amine adsorbents to date are known to suffer from the trade-off between increasing amine content and decreasing access to amine sites. In this work, we propose a solution to this known issue by introducing substrates with multiple pore networks where each pore channel can be used for a
Biogenic sources contribute to cloud condensation nuclei (CCN) in the clean marine atmosphere, but few measurements exist to constrain climate model simulations of their importance. The chemical composition of individual atmospheric aerosol particles showed two types of sulfate-containing particles in clean marine air masses in addition to mass-based Estimated Salt particles. Both types of sulfate particles lack combustion tracers and correlate, for some conditions, to atmospheric or seawater dimethyl sulfide (DMS) concentrations, which means their source was largely biogenic. The first type is identified as New Sulfate because their large sulfate mass fraction (63% sulfate) and association with entrainment conditions means they could have formed by nucleation in the free troposphere. The second type is Added Sulfate particles (38% sulfate), because they are preexisting particles onto which additional sulfate condensed. New Sulfate particles accounted for 31% (7 cm(-3)) and 33% (36 cm(-3)) CCN ...
www.MOLUNA.de Stimulants [4206823] - 1 Amphetamines: Structure-Activity Relationships.- 1. Introduction.- 2. Effects of Biogenic Amines.- 2.1. Norepinephrine.- 2.2. Dopamine.- 2.3. Serotonin.- 3. Central Stimulatory Effects.- 3.1. Phenethylamine Derivatives.- 3.2. Structurally Modified Phenethylamine Derivatives.- 3.3. Pemoline.- 4. Anorexic Effects.- 5. Inhibition of Monoamine Oxidase.- 6. Psychotomimetic Effects.- 7. Summary.- 8. References.- 2 Amphetamines: Biochemical and
The learning and memory deficits have been recognized as severe and consistent neurological disorders associated with numerous neurodegenerative states. Research in this area has gained momentum only in the recent past after the biochemical and physiological basis of these processes have been understood. A considerable alteration in the neurotransmission is a consistent finding in cognitive disorders. Therefore, many therapeutic strategies to augment the concentration of neurotransmitters in brain such as cholinergic agents, biogenic amines and neuropeptides etc. have been evaluated in cognitive deficits. CNS modulators are the type of antiamnesics that act via modulation of the neurological processes underlying memory storage. These include psychostimulants, excitatory amino acids and most important of all "nootropics". Nootropics are a heterogeneous group of compounds of diverse chemical composition and biological function that allegedly facilitate learning and memory or overcome natural or ...
The most important biogenic amine, histamine impacts health & behavior through its four receptors. Discover its function & genetics here.
Cold-water corals form substantial biogenic habitats on continental shelves and in deep-sea areas with topographic highs, such as banks and seamounts. In the Atlantic, many reef and mound complexes...
BioAssay record AID 1053182 submitted by The Scripps Research Institute Molecular Screening Center: Counterscreen for antagonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based late stage dose response assay to identify TAAR1 Agonists (MedChem Round 2).
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A field campaign to elucidate the impact of biogenic aerosols on clouds and climate, Petäjä, T., OConnor E.J., Moisseev D., Sinclair V.A., Manninen A.J., Väänänen R., Von Lerber A., Thornton J.A., Nicoll K., Petersen W., et al. , Bulletin of the American Meteorological Society, Volume 97, Number 10, p.1909-1928, (2016) ...
Definition: Component found in mineralized tissue, (a specialized form of biogenic tissue in which the extracellular matrix is mineralized ...
Recent evidence suggests that the trace amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmission and psychostimulant action. Several selective TAAR1 agonists have previously shown efficacy in models of cocaine addiction. However, the effects of TAAR1 activation on methamphetamine (METH)-induced behaviours are less well understood, as indeed are the underlying neurochemical mechanisms mediating potential interactions between TAAR1 and METH. Here, in a progressive ratio schedule of reinforcement the partial TAAR1 agonist, RO5263397, reduced the break-point for METH self-administration, while significantly increasing responding maintained by food reward. Following self-administration and extinction training, RO5263397 completely blocked METH-primed reinstatement of METH seeking. Moreover, when used as a substitute, unlike a low dose of METH, which sustained vigorous responding when substituting for the training dose of METH, RO5263397 was not self
The simultaneous determination of 17 free amino acids and 8 biogenic amines in Alicante Monastrell wines was investigated for the first time. The quantification was carried out by using a RP-HPLC method. based on a pre-column derivatization with o-phthaldialdehyde (OPA) and fluorescence detection. From the results obtained it may be concluded that the most abundant free amino acids were Glu, Arg, Ala Asp, and Lys. None of the wine samples analysed had histamine (HIM) or Tyramine (TYM) levels above the limits considered as a possible toxic risk for healthy individuals. No measurable amounts of cadaverine (CAD) or methylamine (MEA) were found, showing no spoilage symptoms of sensory properties of the wines. Tryptamine (TRM) content was significantly higher in aged wines compared to young wines. However ethanolamine (ETA) content was lower. These data were used to make a preliminary classification of the samples using cluster analysis. (C) 2012 Elsevier Ltd. All rights reserved ...
Article first published online: 8 SEP 2015. LINK. "The CI1 Orgueil meteorite is a highly aqueously altered carbonaceous chondrite. It has been extensively studied, and despite its extensive degree of aqueous alteration and some documented instances of contamination, several indigenous organic compounds including amino acids, carboxylic acids, and nucleobases have been detected in its carbon-rich matrix. We recently developed a novel gas chromatographic method for the enantiomeric and compound-specific isotopic analyses of meteoritic aliphatic monoamines in extracts and have now applied this method to investigate the monoamine content in Orgueil. We detected 12 amines in Orgueil, with concentrations ranging from 1.1 to 332 nmol g−1 of meteorite and compared this amine content in Orgueil with that of the CM2 Murchison meteorite, which experienced less parent-body aqueous alteration. Methylamine is four times more abundant in Orgueil than in Murchison. As with other species, the amine content in ...
The effect of gutting and filleting on the formation of biogenic amines and its relation to microbiological and sensory attributes in ice-stored sea bass (Dicentrarchus labrax) was studied. Pseudomonads, H2S-producing bacteria, Brochothrix thermosphacta and to a lesser extent Enterobacteriaceae were the dominant micro-organisms in whole, gutted and filleted sea bass. Higher populations (P,0.05) of these micro-organisms were present in filleted sea bass as compared to gutted and whole fish samples. Seven biogenic amines namely: putrescine, cadaverine, spermidine, tyramine, tryptamine, spermine and histamine were determined in fish samples. Putrescine was the main biogenic amine formed. Its highest value (23.86 mg/kg) was recorded in filleted sea bass on day 16 of storage. Respective putrescine values for gutted and whole sea bass were 12.64 and 3.12 mg/kg (day 16). Putrescine levels of whole, gutted and filleted sea bass showed a steep increase between days 11 and 16 of storage when respective ...
Looking for online definition of Trace amine receptor 4 in the Medical Dictionary? Trace amine receptor 4 explanation free. What is Trace amine receptor 4? Meaning of Trace amine receptor 4 medical term. What does Trace amine receptor 4 mean?
ENCODES a protein that exhibits trace-amine receptor activity (ortholog); INVOLVED IN sensory perception of chemical stimulus (ortholog); FOUND IN integral component of membrane (inferred); plasma membrane (inferred); INTERACTS WITH 17beta-estradiol; bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
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cdna:known chromosome:VEGA66:10:23970706:23971719:1 gene:OTTMUSG00000019210 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Taar5 description:trace amine-associated receptor 5 ...
The obvious advantage for clinician-scientists is their involvement in all aspects of translational medicine. Many times this is termed bench-to-bedside medicine, which aims to test new therapeutic concepts in the lab and bring new treatments into the clinic. Although this is the desire of most, if not all, clinical-scientists, I now realize that ideas and experience move in both directions and more frequently flow from bedside to bench. Clinician-scientists interact with patients, see the clinical features of their diseases, and then develop basic science experiments to test new ideas that stem from this experience.. As a fellow, I became interested in a rare neurodevelopmental disorder, called Rett syndrome, and the role of biogenic amines (the neurotransmitters: dopamine, norepinephrine and serotonin) in this disease. Many of the clinical features found in Rett syndrome suggest alterations in these neurotransmitters. Therefore, I designed a human study to collect spinal fluid from ...
The prevalence of some chronic diseases, such as cancer or neurodegenerative disorders, differs between sexes. Animal models provide an important tool to adopt potential therapies from preclinical studies to humans. Laboratory rats are the most popular animals in toxicology, neurobehavioral, or cancer research. Our study aimed to reveal the basic differences in blood metabolome (amino acids, biogenic amines, and acylcarnitines) of the adult male (n = 10) and female (n = 10) Wistar rats. Partial least square-discrimination analysis (PLS-DA) and a variance im portance in projection (VIP) score was used to identify the key sex-specific metabolites. All groups of metabolites, as the main markers of energy metabolism, showed a significant sex-dependent pattern. The most important features calculated in PLS-DA according to VIP score were free carnitine (C0), tyrosine (Tyr), and acylcarnitine C5-OH. While aromatic amino acids, such as Tyr and phenylalanine (Phe), were significantly elevated in the blood plasma
The goals of this Core are to: (1) Measure small molecules (primarily amino acids and biogenic amines) of central importance to brain chemistry....
Control containing a comprehensive analyte menu for quantitative assays that monitor the precision of tests for general urine chemistry, biogenic amines, and hormones; contains hCG (Pregnancy) and Microalbumin
Although bacteria release a wide diversity of volatile compounds that can diffuse in heterogeneous mixes of solids, liquids and gaseous milieu such as soil, organic tissues and microbial mats, little is known about their biological functions (Kai et al., 2009). Here we show that bacterial uptake and metabolism of biogenic ammonia increases the intracellular level of polyamines and influences antibiotic resistance and oxidative stress responses.. Ammonia production results from the metabolism of peptide and amino acid, the principal carbon sources in many environments, in which l-aspartate generally plays a central role in ammonia production as one of the most highly catabolysable amino acids in most bacteria (Reitzer, 2003; Sezonov et al., 2007; Alteri et al., 2009). Ammonia was previously shown to influence later stages of Dictyostelium discoideum development (Schaap et al., 1995) and to be involved in long-distance co-ordination of yeast growth leading to optimal distribution in their natural ...
Riethdorf, Jan-Rainer; Nürnberg, Dirk; Max, Lars; Tiedemann, Ralf; Gorbarenko, Sergey A; Malakhov, Mikhail I (2013): Stable isotopes, core logging data, relative paleointensity, dry bulk density, biogenic opal, CN-data (TC, TOC, CaCO3, TN), element concentrations, and coarse fraction of three sediment cores from the western Bering Sea. PANGAEA, https://doi.org/10.1594/PANGAEA.786307, Supplement to: Riethdorf, J-R et al. (2013): Millennial-scale variability of marine productivity and terrigenous matter supply in the western Bering Sea over the past 180 kyr. Climate of the Past, 9(3), 1345-1373, https://doi.org/10.5194/cp-9-1345-2013
I doubt this letter would accomplish anything more if it was printed. Im sending it because I want to improve the content and influence of Antiwar.com, not because I want to score snark points against one of your columnists whose work I often enjoy. I must start out, however, by saying that I am very disappointed (perhaps embarrassed) regarding "Ethanol: A Threat to National Security?" Ill use point form to inhibit the argumentative nature of what I would otherwise write.. 1. The main thrust of this column (beginning about halfway through) is difficult to interpret. I think this is mostly due to factual inaccuracies rather than unusually bad writing. Ill give examples of minor factual inaccuracies later and focus on the main ones first.. 2. Prathers argument seems to be something like this: burning of biogenic hydrocarbons is the main worry regarding anthropogenic greenhouse warming; some petroleum and other stuff we burn might not be biogenic; burning ethanol (biogenic carbon) is worse than ...
Trace Amine receptor 4 antibody (trace amine associated receptor 6) for IHC-P. Anti-Trace Amine receptor 4 pAb (GTX70805) is tested in Human samples. 100% Ab-Assurance.
TAAR1 - TAAR1 (Myc-DDK-tagged)-Human trace amine associated receptor 1 (TAAR1) available for purchase from OriGene - Your Gene Company.
Wholesale Amine Tegar Buih Penebat dari China, Perlu mencari murah Amine Tegar Buih Penebat seperti harga yang rendah tetapi pengeluar terkemuka. Hanya mencari jenama yang berkualiti tinggi di Amine Tegar Buih Penebat menghasilkan kilang, Anda boleh juga maklum balas tentang apa yang anda mahu, mula menyimpan dan meneroka kami Amine Tegar Buih Penebat, Kamiakan membalas anda dalam terpantas ...
The contribution of primary biogenic organic aerosols to PM is barely documented. This work provides a broad overview of the spatiotemporal evolution of concentrations and contributions to OM of dominant primary sugar alcohols and saccharides for a large selection of environmental conditions in France (28 sites and more than 5 340 samples). These chemicals are ubiquitous, and are associated with coarse aerosols. Their concentrations display site-to-site and clear seasonal variations ...
... by Yulia Berry. Your step-by-step manual for home and beauty remedies using aloe. Learn about the biogenic stimulation method when making aloe juice at home
Amine Naming 2 In this tutorial, Sal shows how to name amines. This Video is the part of the Naming amines and of the topic A...
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This page includes the following topics and synonyms: Tyramine-Vasoactive Amines, Tyramine Containing Food, Tyramine Elimination.
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Do call me; he, again for which we, women, were all he to begin with. See, its just that I was born different. Bestowed with unimaginable hardships to begin with, overcome, and become and as also maybe to serve as a side living example, perhaps as a side little remembrance of that very sacred creation…
This is an automatic widget added on Third Bottom Widget box (Bottom Widget 3). To edit please go to Appearance > Widgets and choose 3rd widget from the top in area second called Bottom Widget 3. Title is also manageable from widgets as well ...
Tahar Bajjou, Youssef Akhouad, Farida Hilali, Safae Elkochri, Abdelilah Laraqui, Nadia Touil, Idriss Lahlou Amine, Fattouma Mahassine, Yassine Sekhsokh ...
Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):105-13. doi: 10.1107/S0907444912043326. Epub 2012 Dec 20. Research Support, N.I.H., Intramural; Research Support, U.S. Govt, Non-P.H.S.
Nitrogen assimilation during growth of Candida boidinii on methylated amines as sole nitrogen source involves NADP-dependent glutamate dehydrogenase. Changes in enzyme activities during the adaptation of the yeast from growth on ammonium to growth on trimethylamine were examined. No ammonia, dimethylamine or monomethylamine could be detected in the medium during growth on trimethylamine. When two methylated amines were supplied together, they were used simultaneously, although monomethylamine was metabolized more quickly than the others. When cells were grown on a low concentration of ammonium plus higher concentrations of di- or trimethylamine, the ammonium was used first. NADP-dependent glutamate dehydrogenase was the first enzyme to be derepressed, followed by methylamine oxidase and formaldehyde dehydrogenase. Di- and trimethylamine mono-oxygenase activities only appeared when the ammonium concentration fell below 0.5 mM. At this point amine utilization could be detected and no diauxic lag was
Changes in bioavailability of phosphorus (P) during pedogenesis and ecosystem development have been shown for geogenic calcium phosphate (Ca-P). However, very little is known about long-term changes of biogenic Ca-P in soil. Long-term transformation characteristics of biogenic Ca-P were examined using anthropogenic soils along a chronosequence from centennial to millennial time scales. Phosphorus fractionation of Anthrosols resulted in overall consistency with the Walker and Syers model of geogenic Ca-P transformation during pedogenesis. The biogenic Ca-P (e.g., animal and fish bones) disappeared to 3% of total P within the first ca. 2,000 years of soil development. This change concurred with increases in P adsorbed on metal-oxides surfaces, organic P, and occluded P at different pedogenic time. Phosphorus K-edge X-ray absorption near-edge structure (XANES) spectroscopy revealed that the crystalline and therefore thermodynamically most stable biogenic Ca-P was transformed into more soluble forms ...
Polyurethane scaffolds (PUs) have a good biocompatibility but lack cell recognition sites. In this study, we functionalized the surface of a PU, P(D/L)LA and PCL (50:50) containing urethane segments, with heparin. The first step in this functionalization, aminolysis, lead to free amine groups on the surface of the PU. Free amine content was determined to be 6.4 nmol/mL/mg scaffold, a significant increase of 230%. Subsequently, heparin was crosslinked. Immunohistochemistry demonstrated the presence of heparin homogeneous throughout the 3D porous scaffold. Youngs modulus decreased significantly till 50% of the native stiffness after aminolysis and did not change after heparin crosslinking. Contact angle on PU films significantly decreased from 82.7 degrees to 64.3 degrees after heparin crosslinking, indicating a more hydrophilic surface. This functionalization beholds great potential for tissue engineering purposes. When used in a load-bearing environment, caution is necessary due to reduction in ...
Prostaglandin F2α constricted pial arterioles when locally applied to the cerebral surface. Norepinephrine and serotonin each elicited similar contractile effects. The constriction produced by F2α in combination with either biogenic amine was greater than the constriction elicited by F2α or amine acting alone. The effect of one agent on the other was additive rather than potentiating. Since F2α, norepinephrine and serotonin are all naturally occurring agents, it is possible that their combined effect is important under pathological circumstances and this combined effect should not be overlooked in the search for single spasmogens of great potency. Before ascribing a pathologically important effect to F2α, either alone or in combination, evidence is required showing that doses effective in experiments are similar to the concentrations occurring during disease states and/or that vessels may become hypersensitive to F2α during such states.. ...
The putative role of the N-terminal region of rhodopsin-like 7 transmembrane biogenic amine receptors in agonist-induced signaling has not yet been clarified despite recent advances in 7 transmembrane receptor structural biology. Given the existence of N-terminal nonsynonymous polymorphisms (R6G;E42G) within the HTR2B gene in a drug-abusing population, we assessed whether these polymorphisms affect 5-hydroxytryptamine 2B (5-HT2B) receptor in vitro pharmacologic and coupling properties in transfected COS-7 cells. Modification of the 5-HT2B receptor N terminus by the R6G;E42G polymorphisms increases such agonist signaling pathways as inositol phosphate accumulation as assessed by either classic or operational models. The N-terminal R6G;E42G mutations of the 5-HT2B receptor also increase cell proliferation and slow its desensitization kinetics compared with the wild-type receptor, further supporting a role for the N terminus in transduction efficacy. Furthermore, by coexpressing a tethered wild-type 5-HT2B
Epinephrine can be synthesized in the human organism from the amino acid, phenylalanine or tyrosine. The required reaction steps for the synthesis take mainly place in the chromaffin cells of the adrenal medulla. The postsynaptic neurons of the sympathetic dont have the enzyme N- methyl transferase, what leads to the fact that the synthesis of adrenaline from norepinephrine is not possible. In the first step of adrenaline biosynthesis, the enzyme tyrosine hydroxylase provides the tyrosine molecule at C3-atom with a second hydroxylgroup and is thus than a 3.4-Dihydroxyphenylalanin (DOPA). After that the enzyme DOPA decarboxylase, decarboxylases the resulting molecule into biogenic amine dopamine ...
Histamine is a potent signaling molecule or biogenic amine made from the amino acid histidine. It is naturally found in plants and animals. Histamine helps regulate many bodily functions including digestion, sleep, sexual function, and blood pressure; and in the...
Please can you write a detailed post on Histamine intolerance, where most of even healthy looking foods are giving you problem. This is something that is not being treated in a routine medical field. truth is millions are suffering without knowing about it and are being treated for depression/anxiety etc. etc. Only a few Doctors are willing to think and trained in this area. I know That seems selfish but I feel I am in severe stage of this syndrome with more severe symptoms - heart palpitations, migrains, neurological symptoms, muscle spasms/twitches, numbness, that got worst in last 2 months and made me to discover I was suffering from this at a milder level since my childhood. I have a very healthy lifestyle with mostly homemade food made from scratch, but always felt unwell, compared to people who are eating just junk. I always knew something is wrong metabolically, but recent episode of full blown above symptoms made me research and I concluded I have some kind of biogenic amine/histamine ...
I wonder how hard it would be to steal a vegetable body from a hospital, set up a life-support system in my lab and jsut tweak his biochemistry to the desired enzyme stats and start pushing apiole or safrole into his liver... but then again, rabbits are far more efficient for that particular conversion... "Determination of biogenic amines in wine after clean-up by solid-phase extraction" - O. Busto, M. Mestres, J. Guasch and F. Borrull says that simple ion exchange cartridges and HPLC is pulling 50ug/L of phenethylamine derivatives from commercial wines.. with a little adaption, it shouldnt be too hard to be cleaning at least 100mg/L of beta-phenthylamine from a decent cadaver. most bodies are about 11% blood of mass, so for your average human male were talking 4.7-5 litres... 500mg of b-PEA suitably preserved with a dash of NaF is enough for a little under 300mg of molly, via the easiest (but not the best-yeilding) pathway... with a lot of good equipment I could probably get 90-100% ...
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A system for interfacing electrochemical detection with micellar electrokinetic capillary chromatography is demonstrated. This system couples the separation column to a short length of the same column material together with a section of porous graphite tubing which forms an electrically conductive joint. The joint is immersed in a buffer reservoir together with the ground electrode of the high-power source (15 kV). The reservoir is electrically insulated from the electrochemical cell containing the carbon fibre detector. This configuration effectively separates the detector from the high separation potential applied. Amperometric detection with micellar solutions is demonstrated for a mixture of B6 vitamers on a 50 μm I.D. column. A detection limit of ca. 4 fmol is obtained. The linear dynamic range of the calibration plot is slightly over two orders of magnitude (from ca. 1 to 200 ppm). © 1991 ...
A high-performance liquid chromatography-electrochemical detection (HPLC-ECD) method was developed to determine cyclovirobuxin D (CVB-D) levels in tablets and human blood samples. A column with a positive charge-modified C18 stationary phase, C18HCE, was selected to analyze CVB-D, because it provided a sharper and more symmetric peak for CVB-D than conventional C18 stationary phase. Two types of working electrode materials, glassy carbon (GC) and boron-doped diamond (BDD), were evaluated. BDD was found to provide better sensitivity than GC owing to its lower background current and baseline noise. Utilizing the BDD electrode, C18HCE column, and optimized mobile phase composition, the developed HPLC-ECD method showed a much better sensitivity. The limit of detection and limit of quantification of the HPLC-ECD method for CVB-D were 0.198 and 0.297 μg/L, respectively. It was approximately 12727, 11481, and 2630 times more sensitive than ultraviolet (UV), evaporative light scattering detection, and ...
Abstract Capillary electrophoresis was applied to the analysis of a mixture of triazine herbicides of environmental interest. Micellar electrokinetic capillary chromatography (MECC) proved to be satisfactory for the separation of triazines, providing high efficiency in short analysis times. Several...
A single injection of 100 micrograms reserpine into the crop of the medicinal leech, Hirudo medicinalis, reduced CNS serotonin and dopamine levels to less than 1% of control values within 3 d. High-pressure liquid chromotography- (HPLC) determined CNS serotonin and dopamine levels remained maximally depressed for approximately 1 month following reserpine injection. Subsequently, amine levels recovered slowly, but remained depressed 6 months after reserpine injection. Following reserpine treatment, glyoxylic acid-induced fluorescence or neutral red staining closely mirrored the HPLC-determined time course of amine depletion and recovery. Acute exposure of isolated ganglia to 10 microM reserpine for periods up to 6 hr produced a 20-30% reduction of serotonin and dopamine content. The threshold concentration of reserpine necessary to produce amine depletion was approximately 1 microM. We found that reserpine treatment eliminated biting behavior within 4 d following injection. Biting behavior ...
Influence of soymilk and skim milk on growth and antibacterial activity of lactic acid bacteria biogenic amine;lactic acid bacteria;skim milk;soymilk; The purpose of this study was to investigate the effect of lactic acid bacteria (LAB) on the growth and biogenic amines (BA) formation of Enterobacter aerogenes CIH05 in skim milk and soymilk. Lactobacillus acidophilus GK20, Lactobacillus paracasei GK74, and Lactobacillus plantarum GK81 isolated from mustard kimchi did not produce BA in the decarboxylation broth. L. paracasei GK74 exhibited the highest cell viability and antimicrobial compounds producing ability in fermented skim milk and soymilk samples, while the lowest producer was L. plantarum GK81. The production yield of lactic acid, hydrogen peroxide, and bacteriocin was dependent on the species of Lactobacillus and the type of culture medium. As LAB the number of viable cells of E. aerogenes CIH05 were higher in skim milk than in soymilk. When mixed culture with L. acidophilus GK20 and L.
To investigate the role of certain neurohormones in agonistic behaviour, fights were staged between pairs of size-matched male shore crabs Carcinus maenas, and blood samples were taken immediately after the contests had been resolved. Samples were also taken from these crabs at rest (before and after fighting) and after walking on a treadmill. A control group of crabs also had samples taken on each experimental day. Concentrations of tyramine, dopamine, octopamine, serotonin (5-HT) and norepinephrine were determined in each blood sample using a gas chromatography/mass spectrometry (GC-MS) system. Norepinephrine was not detectable in any of the samples, but the standards were recovered. Tyramine values were not significantly different between the control group and the fought group, so tyramine does not appear to be important in agonistic behaviour. A comparison between the control and fought groups shows that fighting had an effect on the concentrations of octopamine, dopamine and 5-HT, but ...
This structural motif has potential for high affinity binding to biogenic amine transports.[35] Drugs containing an ... The mechanism of action of tricyclic secondary amine antidepressants is only partly understood. TCAs have dual inhibition ... This is because of a formation of secondary amine TCA metabolites.[28][29] ... 3-arylpropan-1-amines". Bioorganic & Medicinal Chemistry. 14 (24): 8455-66. doi:10.1016/j.bmc.2006.08.039. PMID 16973367.. ...
Biogenic amine receptor. *Olfactory receptor. Class B. *Secretin receptor. Class C. *Metabotropic glutamate receptor ...
... interspecific combinations and cytochemical characterization of C cells based on the uptake of biogenic amine precursors". ...
... the amine becomes quaternized to give betaine, a natural product: H. 3N+. CH. 2COO−. + 3 CH3I → (CH. 3). 3N+. CH. 2COO−. + 3 HI ... Biogenic amines. Monoamines. *6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ... The amine undergoes the expected reactions. With acid chlorides, one obtains the amidocarboxylic acid, such as hippuric acid[23 ... the French chemist Auguste Cahours determined that glycine was an amine of acetic acid.[16] ...
The main component of bee venom responsible for pain in vertebrates is the toxin melittin; histamine and other biogenic amines ...
... through activation of a trace amine receptor, increases biogenic amine and excitatory neurotransmitter activity in the brain, ... Methamphetamine (contracted from N-methyl-alpha-methylphenethylamine) is a neurotoxin and potent psychostimulant of the ... Ephedrine is a sympathomimetic amine similar in molecular structure to the well-known drugs phenylpropanolamine and ... Many drugs in this class work primarily by activating trace amine-associated receptor 1 (TAAR1);[38] in turn, this causes ...
Biogenic amine receptor. *Olfactory receptor. Class B. *Secretin receptor. Class C. *Metabotropic glutamate receptor ...
GPCRs respond to extracellular signals mediated by a huge diversity of agonists, ranging from proteins to biogenic amines to ... biogenic amines (e.g., dopamine, epinephrine, norepinephrine, histamine, serotonin, and melatonin); glutamate (metabotropic ...
Richelson E, Pfenning M (1984). "Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain ...
... and alpha-methyltyrosine on brain biogenic amines". Federation Proceedings. 35 (14): 2558-2562. PMID 11134.. .mw-parser-output ...
Biogenic amines: Monoamines: Dopamine. *Epinephrine (adrenaline). *Histamine. *Melatonin. *NAS (normelatonin). *Norepinephrine ... ল্যাটিন হিস্টোস (Histos) শব্দটির অর্থ প্রাণী কলা বা শরীরের ট্যিসু এবং আয়ামিন (Amine) শব্দটি বোঝায় প্রাণীজ এমিন যা তৈরি হয় ... Beta-imidazoyl ethyl amine)। মূলত, হিস্টামিন সকল স্তন্যপায়ী কলায় উপস্থিত থাকে এবং শরীরের রোগ প্রতিরক্ষা ব্যবস্থায়, ...
There are several nitrogenous compounds found in must and wine including peptides, larger proteins, amides, biogenic amines, ...
Trace amine. References[edit]. *^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, ... T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein- ... Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). "Trace amine-associated receptor agonists: synthesis and ... References for all endogenous human TAAR1 ligands are provided at List of trace amines ...
"Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar ...
Most LAB have the potential to create biogenic amines, even some strains of O. oeni, but high levels of biogenic amines are ... Finally, O. oeni tends to produce the least amount of biogenic amines (and most lactic acid[3]) among the lactic acid bacteria ... Biogenic amines have been implicated as a potential cause of red wine headaches. In wine, histamine, cadaverine, ... Cadaverine is one of the biogenic amines that some LAB species, particularly from the Lactobacillus and Pediococcus genera, ...
Some strains of LAB can produce biogenic amines, such as histamine, tyramine and putrescine, which may be a cause of red wine ...
biogenic amines *Histamine. *Serotonin. synthesized on demand:. *cytokines *IFN-γ. *IL-8 ...
"Intolerance to dietary biogenic amines: a review". Annals of Allergy, Asthma & Immunology. svezak 91 (broj 3): str. 233.-240.; ...
"Intolerance to dietary biogenic amines: a review". Annals of Allergy, Asthma & Immunology. 91 (3): 233-240, quiz 241-242, 296. ...
... primarily sympathomimetic amine and 2-imidazoline derivatives) and topical decongestants (e.g., oxymetazoline, phenylephrine, ...
Biogenic amines. Monoamines. *6-OHM. *Dopamine. *Epinephrine (adrenaline). *NAS (normelatonin). *Norepinephrine (noradrenaline) ...
... and alpha-methyltyrosine on brain biogenic amines". Federation proceedings 35 (14): 2558-2562. PMID 11134. ...
Important amines include amino acids, biogenic amines, trimethylamine, and aniline; see Category:Amines for a list of amines. ... Cyclic amines-Cyclic amines are either secondary or tertiary amines. Examples of cyclic amines include the 3-membered ring ... Lower amines are named with the suffix -amine.. methylamine Higher amines have the prefix amino as a functional group. IUPAC ... "Amine definition and meaning". Collins English Dictionary. Retrieved 2017-03-28.. *^ "amine - definition of amine in English". ...
About 30% of people are sensitive to biogenic amines, such as histamines.[73] ... The amines in red wine and Chardonnay produce off-flavors and cause headaches and hypertension in some people. ... Researchers from the University of British Columbia, Canada, have found a new strain of yeast that has reduced amines. ...
"Long-Acting Blockade of Biogenic Amine Transporters in Rat Brain by Administration of the Potent Novel Tropane 2β-Propanoyl-3β ...
biogenic amines *Histamine. *Serotonin. synthesized on demand:. *cytokines *IFN-γ. *IL-8 ...
"Studies of the biogenic amine transporters. VI. Characterization of a novel cocaine binding site, identified with [125I]RTI-55 ...
"Analysis of biogenic amines and their metabolites in biological tissues and fluids by gas chromatography-negative ion chemical ... "HPLC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine ... a b B. Avula, S. K. Upparapalli, and I. A. Khan (2007). "Simultaneous analysis of adrenergic amines and flavonoids in citrus ... Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends Pharmacol. Sci. 26 ( ...
The trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine ... It is currently thought that the biological activities elicited by trace amines such as p-tyramine and the psychostimulant ... and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor by. Bunzow JR, Sonders MS, ... These results suggest that the trace amines and catecholamine metabolites may serve as the endogenous ligands of a novel ...
Brain Biogenic Amine Depletion and Mood. / Mendels, Joseph; Frazer, Alan.. In: Archives of General Psychiatry, Vol. 30, No. 4, ... Mendels, J., & Frazer, A. (1974). Brain Biogenic Amine Depletion and Mood. Archives of General Psychiatry, 30(4), 447-451. ... Mendels, J & Frazer, A 1974, Brain Biogenic Amine Depletion and Mood, Archives of General Psychiatry, vol. 30, no. 4, pp. 447 ... Brain Biogenic Amine Depletion and Mood. In: Archives of General Psychiatry. 1974 ; Vol. 30, No. 4. pp. 447-451. ...
Key words: micellar electrokinetic capillary chromatography (MECC) biogenic amines fish Received: 2007-06-12; Published: 2007- ... Seven biogenic amines (BAs) were extracted from a sample with 6% perchloric acid, then derivatized with benzoyl chloride. 0.02 ... Determination of five biogenic amines in source water by ion chromatography[J]. Chinese Journal of Chromatography, 2009, 27(4 ... Determination of Seven Biogenic Amines in Fish Using Micellar Electrokinetic Capillary Chromatography ...
Neuroreactive Substance or Biogenic Amine. A1.4.1.1.3.2. Hormone. A1.4.1.1.3.3. Enzyme. A1.4.1.1.3.4. Vitamin. A1.4.1.1.3.5. ...
Neuroreactive Substance or Biogenic Amine. A1.4.1.1.3.2. Hormone. A1.4.1.1.3.3. Enzyme. A1.4.1.1.3.4. Vitamin. A1.4.1.1.3.5. ...
Pharmacologically, this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important ...
Biogenic Amines * 5-HIAA * Adrenaline/Epinephrine * Melatonin * Noradrenaline/Norepinephrine * Metanephrenine/Normetanephrine * ...
Biogenic Amines. *Cardiac Markers. *Endocrinology Diagnostics. *Food Analytic / Safety. *Immunology / Cytokines. *Infectious ...
They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This ...
Biogenic amines are labeled as toxic food because its consumption exceeding the FDA regulation (50 mg/kg) can be harmful to ... 6. The Importance of Derivatizing Reagent in Chromatography Applications for Biogenic Amine Detection in Food and Beverages ... Biogenic amines (BA) are chemical compounds formed in foods that contain protein, allowing the foods to undergo a bacterial ... Some countries also have regulations that prohibit the consumption of biogenic amines in high concentrations, especially hi ... ...
Biogenic Amines. *Cardiac Markers. *Endocrinology Diagnostics. *Food Analytic / Safety. *Immunology / Cytokines. *Infectious ...
TITLE: Biogenic Amine Neurotransmitter Response to Morphine in the Anterior Cingulate Cortex Predicts Propensity for Acquiring ... The initial response of extracellular fluid levels of the biogenic monoamine neurotransmitters in the anterior cingulate cortex ...
Biogenic amines and emotion. (opens in new tab). Science. J J Schildkraut, S S Kety ...
The overall goal of this thesis was to determine the amounts of stimulants in PWS, both the biogenic amines derived from Citrus ... To address these questions, the aims were to develop two HPLC protocols for the quantitation of 1) adrenergic amines present in ...
... phenethylamine compounds that achieve their neurochemical and behavioral effects by liberating vesicular biogenic amine stores ...
Besides neuropeptides it is also known that biogenic amines especially serotonin possesses expressed influence on feeding ...
Biogenic Amine reference materials. Download Designer Fentanyls - Drugs that kill and how to detect them: Cyclopropyl-fentanyl ...
Flora S.J., Saxena G., Gautam P., Kaur P., Gill K. Response of lead-induced oxidative stress and alterations in biogenic amines ...
Biogenic Amines *2-CAT. *2-MET. *3-CAT. *5-Hydroxy-3-Indole Acetic Acid (5-HIAA) ...
Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be ... and agmatine are considered to be the most important biogenic amines occurring in foods " ... rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. ... Do the amines diffuse into the meat or are they only present on the surface?. Thanks, Joe. ...
2012) Biogenic Amines Degradation by Lactobacillus plantarum: Toward a Potential Application in Wine. Front Microbiol. 2012; 3 ... Screening selected strains of probiotic lactic acid bacteria for their ability to produce biogenic amines (histamine and ...
The fact that copper-dependent amine oxidases (CDAOs) eliminate diverse biogenic amines and are induced in states of neuronal ... Tracking levels of biogenic amines such as dopamine added to physiologic solutions of variable ionic and polar character ... Because amines typically only assume a +1 charge, and have higher MW than divalent cations, this asymmetry could be the basis ... Support of amine oxidase function in the presence of copper would explain protection of neuronal cells against mutant cu/zn SOD ...
Biogenic Amines * 5-HIAA * Adrenaline/Epinephrine * Melatonin * Noradrenaline/Norepinephrine * Metanephrenine/Normetanephrine * ...
... ethan-1-amine in book II of PiHKAL: A Chemical Love Story. Alexander & Ann Shulgin ... Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. Psychopharmacology, 1 ... The vascular effects of trace amines and amphetamines. Pharmacol. Ther., 1 Mar 2010, 125 (3), 363-375. 1.1 MB. https://doi.org/ ...
... these novel acridone derivatives exhibited no demonstrable effect on the uptake or binding of important biogenic amine ...
  • T he trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine neurotransmitters. (mdma.net)
  • It is currently thought that the biological activities elicited by trace amines such as p-tyramine and the psychostimulant amphetamines are manifestations of their ability to inhibit the clearance of extracellular transmitter and/or stimulate the efflux of transmitter from intracellular stores. (mdma.net)
  • Here we report the discovery and pharmacological characterization of a rat G protein-coupled receptor that stimulates the production of cAMP when exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine. (mdma.net)
  • An extensive pharmacological survey revealed that psychostimulant and hallucinogenic amphetamines, numerous ergoline derivatives, adrenergic ligands, and 3-methylated metabolites of the catecholamine neurotransmitters are also good agonists at the rat trace amine receptor 1 (rTAR1). (mdma.net)
  • Jeganathan, PS & Namasivayam, A 1989, ' Brain biogenic amine levels after methanol administration: Possible mechanism of action of central monoaminergic neurons in discrete areas of brain in Wistar rats ', Indian Journal of Physiology and Pharmacology , vol. 33, no. 3, pp. 151-156. (elsevier.com)
  • Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that reported to occur in depressed patients. (uthscsa.edu)
  • More selective amine depletion, produced either by alpha-methyl-paratyrosine or by parachlorophenylalanine is not associated with depression. (uthscsa.edu)
  • We would like to elucidate in detail the "orchestrational" function of biogenic amines as their role in the periphery of modulating synaptic transmission and catabolic pathways is accompanied by specific actions within the nervous system, for example, motor circuits. (frontiersin.org)
  • Chunjang and Jajang samples were analysed for biogenic amine contents by using HPLC equipped with a UV-Vis detector. (nih.gov)
  • Although partial extraction was achieved, the results correlate with total biogenic amine content measured by HPLC method. (elsevier.com)
  • Both biogenic amines and free amino acids were analyzed by HPLC using fluorescence detection for their o-phthalaldehyde/fluorenylmethyl chloroformate (OPA/FMOC) derivatives. (studyres.com)
  • Biogenic amines were quantified using a reversed-phase high performance liquid chromatography HPLC with fluorescence detection after pre-column derivatization with o-phthalaldehyde OPA. (duhnnae.com)
  • In this study, histamine and other biogenic amines were determined by HPLC after amine derivatization to dansyl chloride conjugates in 100 selected high quality red wines made from seven different cultivars. (migrainepolice.com)
  • A such validated colorimetric detection system is likely to be included in further investigations and clinical studies to support food experts, risk managers and medical doctors in their debate on the potential role of biogenic amines in food intolerance. (donau-uni.ac.at)
  • In the case of other amines such as spermine and spermidine, they yielded very low levels varying between 0 and 2.64 mg/l for spermine, 0 and 3.82 mg/l for spermidine, respectively. (infowine.com)
  • M-FSCV was evaluated with two biogenic amine groups (catecholamines and indolamines) to characterize their inherent adsorption/desorption constants. (rsc.org)
  • This study aimed to review the existing data on histamine and other biogenic amine contents in nonfermented plant-origin foods, as well as on their origin and evolution during the storage or culinary process. (dr-healthcare.com)
  • In humans and other mammals, drugs of abuse alter the function of biogenic amine pathways in the brain leading to the subjective experience of reward and euphoria. (peerj.com)
  • This chapter discusses the formation and degradation of biogenic amines, their occurrence in foods, their significance in food safety, their potential use as quality indicators, and the available methods for their determination. (asmscience.org)
  • Biogenic Amine Degradation by Bacillus Species Isolated from Traditional Fermented Soybean Food and Detection of Decarboxylase- Related Genes. (utb.cz)
  • Although there are umpteen biomarkers identified in relation to ASD, abnormalities in biogenic amines from the tryptophan metabolism pathway have been more commonly implicated in ASD. (minervamedica.it)
  • it may be utilized by graduate scholars, postdoctoral fellows, researchers, and scientists who paintings on the pharmaceutical as a guide, which describes all points of biogenic amine metabolism. (aguardienteclothing.com)
  • A high concentration of histamine, one of the biogenic amines (BAs) usually found in fermented foods, can cause undesirable physiological side effects in sensitive humans. (scielo.br)
  • Biogenic amines have nice pharmacological and physiological value. (aguardienteclothing.com)
  • In fermented foods, one can expect the presence of many kinds of microorganisms, some of them being capable of producing biogenic amines. (wikipedia.org)
  • 1994. Biogenic amines and their production by microorganisms in food. (koreascience.or.kr)
  • The problem of biogenic amines in fermented foods and the use of potential biogenic amine-degrading microorganisms as a solution. (utb.cz)
  • In this study, we have developed a microbore high-performance liquid chromatographic method based on precolumn fluorescence derivatization with benzylamine for the determination of the amines in microdialysate from rat brain. (nii.ac.jp)
  • The method is based on the fluorescence derivatization of the amines by reaction with benzylamine in the presence of potassium hexacyanoferrate (III). (nii.ac.jp)
  • The reagent 3,5-dinitrobenzoyl chloride (DNBZ-Cl) was tested for pre-column derivatization of biogenic amines (BAs). (semanticscholar.org)
  • Chemical derivatization processes applied to amine determination in samples of different matrix composition. (semanticscholar.org)
  • A novel solid-phase based derivatization method is reported herein for the detection of biogenic amines in foods and specifically in fish . (umbc.edu)
  • The reagent was reacted with aliphatic and aromatic amines which lead to the derivatization of these amines and consequently to the formation of sulfonamides . (umbc.edu)
  • The reagent was treated with aliphatic or aromatic amines which lead to the derivatization of these amines and the formation of amides . (umbc.edu)
  • Biogenic amines at nanomolar concentration is detected with the additional ability to discriminate between primary, secondary and tertiary amines by using both UV-Visible and fluorescence spectroscopy. (rsc.org)
  • The effects of increased potassium ion concentration in the Ringer solution and a single intraperitoneal injection of methanphetamine on the amine levels in microdialysate were examined. (nii.ac.jp)
  • It is also important to note that certain biogenic amines: cadaverin, putrescin, etc. may taint the wine at high levels of concentration. (sarco.fr)
  • In fact, if lactic acid bacteria are not managed properly, they can lead to problems that include volatile acidity and/or biogenic amine formation. (infowine.com)
  • 2000. Combined ion-pair extraction and gas chromatography - mass spectrometry for the simultaneous determination of diamines, polyamines and aromatic amines in Port wine and grape juice. (koreascience.or.kr)
  • Seafood may harbor a number of biological, chemical, and physical hazards, the most prevalent of which are biogenic amines (BAs) and biotoxins (chemical), pathogenic bacteria and viruses (biological), and metal inclusion (physical). (frontiersin.org)
  • An ultrasensitive ratiometric fluorescent sensor made of an N , N -dimethylaminonaphthalene anhydride moiety for detection of aliphatic primary amines is reported. (rsc.org)
  • The detection limits of the amines are 30-100 amol for a 5mul injection. (nii.ac.jp)
  • The detection limit of histamine was 15 μg/g and those of the other amines were 5 μg/g. (chrom-china.com)
  • In the application of P-HOBT activated with alizarin red S chloride to the detection of biogenic amines and volatiles amines in foods , mackerel , a fish from Scombridae family , was used as a model fish for the study . (umbc.edu)
  • Biogenic amine transporters: regulation in flux. (nih.gov)
  • Recognition that transmitters, antagonists and second messengers can modify the intrinsic activity, surface expression or protein levels of amine transporters raises new questions about the fundamental nature of drug actions in vivo. (nih.gov)
  • This will be accomplished by screening known biogenic amine transporters in heterologous expression systems for monodispersity and their propensity for crystallization. (grantome.com)
  • Traditional foods are an important part of the Portuguese diet, and a high intake of harmful amounts of biogenic amines from traditional Portuguese fermented foods is possible. (up.pt)
  • The strains isolated from a sample in which relatively small amounts of biogenic amines were detected showed significantly weak abilities to produce biogenic amines. (nih.gov)
  • They play an important role as source of nitrogen and precursor for the synthesis of hormones, alkaloids, nucleic acids, proteins, amines and food aroma components. (wikipedia.org)
  • Biogenic amines are organic bases with low molecular weight and are synthesized by microbial, vegetable and animal metabolisms. (wikipedia.org)
  • Our study suggests differences in biogenic amine formation or mycotoxins content in silage from organic and conventional farming , but, overall , the measured values are too low to be relevant for animal health . (bvsalud.org)
  • Biogenic amines are products of the catabolism of all living cell. (sarco.fr)
  • Biogenic amines are molecules resulting from cellular catabolism. (fil-idf.org)
  • The beneficial effects of fish consumption on human health such as protection against coronary heart disease and certain cancer may be offset by fish decomposition and the formation of chemical contaminants such as biogenic amines. (biomedsearch.com)
  • HP seems to be effective for reducing the formation of biogenic amines in this kind of product. (biomedsearch.com)
  • on biogenic amine formation during the ripening of dry fermented sausages. (koreascience.or.kr)