Biofilms. Medical search

Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.

Community of tiny aquatic PLANTS and ANIMALS, and photosynthetic BACTERIA, that are either free-floating or suspended in the water, with little or no power of locomotion. They are divided into PHYTOPLANKTON and ZOOPLANKTON.

A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.

Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.

A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.

Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.

Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.

Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.

A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).

Physiological processes and properties of BACTERIA.

A species of gram-positive, coccoid bacteria that is numerous in the mouth and throat. It is a common cause of endocarditis and is also implicated in dental plaque formation.

A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.

A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

Ionized gases, consisting of free electrons and ionized atoms or molecules which collectively behave differently than gas, solid, or liquid. Plasma gases are used in biomedical fields in surface modification; biological decontamination; dentistry (e.g., PLASMA ARC DENTAL CURING LIGHTS); and in other treatments (e.g., ARGON PLASMA COAGULATION).

Substances that reduce the growth or reproduction of BACTERIA.

The inter- and intra-relationships between various microorganisms. This can include both positive (like SYMBIOSIS) and negative (like ANTIBIOSIS) interactions. Examples include virus - bacteria and bacteria - bacteria.

Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.

A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.

A liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant.

Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

Proteins found in any species of bacterium.

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Polysaccharides found in bacteria and in capsules thereof.

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.

Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

The presence of an infectious agent on instruments, prostheses, or other inanimate articles.

Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.

Electric power supply devices which convert biological energy, such as chemical energy of metabolism or mechanical energy of periodic movements, into electrical energy.

Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.

A genus of gram-positive, rod-shaped bacteria whose organisms are nonmotile. Filaments that may be present in certain species are either straight or wavy and may have swollen or clubbed heads.

A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms.

A group of different species of microorganisms that act together as a community.

Stainless steel. A steel containing Ni, Cr, or both. It does not tarnish on exposure and is used in corrosive environments. (Grant & Hack's Chemical Dictionary, 5th ed)

Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.

A species of gram-negative, anaerobic, rod-shaped bacteria isolated from the gingival margin and sulcus and from infections of the upper respiratory tract and pleural cavity.

Measurable quantity of bacteria in an object, organism, or organism compartment.

The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.

Total mass of all the organisms of a given type and/or in a given area. (From Concise Dictionary of Biology, 1990) It includes the yield of vegetative mass produced from any given crop.

A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)

Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.

Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.

A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity.

A polyvinyl resin used extensively in the manufacture of plastics, including medical devices, tubing, and other packaging. It is also used as a rubber substitute.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

Quaternary salts derived from tetrazoles. They are used in tests to distinguish between reducing sugars and simple aldehydes, for detection of dehydrogenase in tissues, cells, and bacteria, for determination of corticosteroids, and in color photography. (From Mall's Dictionary of Chemistry, 5th ed, p455)

A tetraiodofluorescein used as a red coloring in some foods (cherries, fish), as a disclosure of DENTAL PLAQUE, and as a stain of some cell types. It has structural similarity to THYROXINE.

A species of gram-positive, facultatively anaerobic bacteria in the family STREPTOCOCCACEAE. It is a normal inhabitant of the human oral cavity, and causes DENTAL PLAQUE and ENDOCARDITIS. It is being investigated as a vehicle for vaccine delivery.

Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.

Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.

Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)

Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.

A genus of gram-negative, facultatively anaerobic rods. It is a saprophytic, marine organism which is often isolated from spoiling fish.

A natural association between organisms that is detrimental to at least one of them. This often refers to the production of chemicals by one microorganism that is harmful to another.

Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.

Resistance of artificial biofilms of Pseudomonas aeruginosa to imipenem and tobramycin. (1/4882)

Viable cells of Pseudomonas aeruginosa were entrapped in alginate gel layers and incubated in a minimal glucose (15 g/L)-yeast extract (2 g/L)-salt medium to form artificial biofilm-like structures. After cultivation for 2 days, the biomass distribution inside the polymer was highly heterogeneous. The cell number reached approximately 1011 cells/g gel in the outer regions of the gel structures whereas the inner areas were less colonized (c. 10(8) cells g/gel). Killing of immobilized organisms by imipenem and tobramycin were compared with free-cell experiments (inoculum c. 10(9) cells/mL). Sessile-like bacteria displayed a higher resistance to the two antibiotics used alone or in combination than did suspended cells. Exposure for 10 h to 20 x MIC imipenem and 15 x MIC tobramycin reduced the number of viable immobilized bacteria to 0.3% and 3%, respectively, of the initial cell population, whereas these antibiotic concentrations were much more efficient (bactericidal) against free-cell cultures (5 log kill in 6 h). A synergic effect of tobramycin and imipenem was detected on bacterial suspensions but not on biofilm-like structures. Effective diffusivity measurements showed that the diffusion of imipenem in the alginate layer was not hindered. A slight but significant enhancement of beta-lactamase induction in immobilized cells as compared with their suspended counterparts was insufficient to explain the high resistance of sessile-like bacteria. (+info)

Vibrio cholerae O1 El Tor: identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation. (2/4882)

The rugose colony variant of Vibrio cholerae O1, biotype El Tor, is shown to produce an exopolysaccharide, EPSETr, that confers chlorine resistance and biofilm-forming capacity. EPSETr production requires a chromosomal locus, vps, that contains sequences homologous to carbohydrate biosynthesis genes of other bacterial species. Mutations within this locus yield chlorine-sensitive, smooth colony variants that are biofilm deficient. The biofilm-forming properties of EPSETr may enable the survival of V. cholerae O1 within environmental aquatic habitats between outbreaks of human disease. (+info)

Surface-grafted, environmentally sensitive polymers for biofilm release. (3/4882)

Controlling bacterial biofouling is desirable for almost every human enterprise in which solid surfaces are introduced into nonsterile aqueous environments. One approach that is used to decrease contamination of manufactured devices by microorganisms is using materials that easily slough off accumulated material (i.e., fouling release surfaces). The compounds currently used for this purpose rely on low surface energy to inhibit strong attachment of organisms. In this study, we examined the possible use of environmentally responsive (or "smart") polymers as a new class of fouling release agents; a surface-grafted thermally responsive polymer, poly(N-isopropylacrylamide) (PNIPAAM), was used as a model compound. PNIPAAM is known to have a lower critical solubility temperature of approximately 32 degrees C (i.e., it is insoluble in water at temperatures above 32 degrees C and is soluble at temperatures below 32 degrees C). Under experimental conditions, >90% of cultured microorganisms (Staphylococcus epidermidis, Halomonas marina) and naturally occurring marine microorganisms that attached to grafted PNIPAAM surfaces during 2-, 18-, 36-, and 72-h incubations were removed when the hydration state of the polymer was changed from a wettability that was favorable for attachment to a wettability that was less favorable. Of particular significance is the observation that an organism known to attach in the greatest numbers to hydrophobic substrata (i.e., H. marina) was removed when transition of PNIPAAM to a more hydrated state occurred, whereas an organism that attaches in the greatest numbers to hydrophilic substrata (i.e., S. epidermidis) was removed when the opposite transition occurred. Neither solvated nor desolvated PNIPAAM exhibited intrinsic fouling release properties, indicating that the phase transition was the important factor in removal of organisms. Based on our observations of the behavior of this model system, we suggest that environmentally responsive polymers represent a new approach for controlling biofouling release. (+info)

Ultrasonic enhancement of antibiotic action on Escherichia coli biofilms: an in vivo model. (4/4882)

Biofilm infections are a common complication of prosthetic devices in humans. Previous in vitro research has determined that low-frequency ultrasound combined with aminoglycoside antibiotics is an effective method of killing biofilms. We report the development of an in vivo model to determine if ultrasound enhances antibiotic action. Two 24-h-old Escherichia coli (ATCC 10798) biofilms grown on polyethylene disks were implanted subcutaneously on the backs of New Zealand White female rabbits, one on each side of the spine. Low-frequency (28.48-kHz) and low-power-density (100- and 300-mW/cm2) continuous ultrasound treatment was applied for 24 h with and without systemic administration of gentamicin. The disks were then removed, and the number of viable bacteria on each disk was determined. At the low ultrasonic power used in this study, exposure to ultrasound only (no gentamicin) caused no significant difference in bacterial viability. In the presence of antibiotic, there was a significant reduction due to 300-mW/cm2 ultrasound (P = 0.0485) but no significant reduction due to 100-mW/cm2 ultrasound. Tissue damage to the skin was noted at the 300-mW/cm2 treatment level. Further development of this technique has promise in treatment of clinical implant infections. (+info)

Study of the response of a biofilm bacterial community to UV radiation. (5/4882)

We have developed a bioluminescent whole-cell biosensor that can be incorporated into biofilm ecosystems. RM4440 is a Pseudomonas aeruginosa FRD1 derivative that carries a plasmid-based recA-luxCDABE fusion. We immobilized RM4440 in an alginate matrix to simulate a biofilm, and we studied its response to UV radiation damage. The biofilm showed a protective property by physical shielding against UV C, UV B, and UV A. Absorption of UV light by the alginate matrix translated into a higher survival rate than observed with planktonic cells at similar input fluences. UV A was shown to be effectively blocked by the biofilm matrix and to have no detectable effects on cells contained in the biofilm. However, in the presence of photosensitizers (i.e., psoralen), UV A was effective in inducing light production and cell death. RM4440 has proved to be a useful tool to study microbial communities in a noninvasive manner. (+info)

Characterization of the importance of polysaccharide intercellular adhesin/hemagglutinin of Staphylococcus epidermidis in the pathogenesis of biomaterial-based infection in a mouse foreign body infection model. (6/4882)

The production of biofilm is thought to be crucial in the pathogenesis of prosthetic-device infections caused by Staphylococcus epidermidis. An experimental animal model was used to assess the importance of biofilm production, which is mediated by polysaccharide intercellular adhesin/hemagglutinin (PIA/HA), in the pathogenesis of a biomaterial-based infection. Mice were inoculated along the length of a subcutaneously implanted intravenous catheter with either wild-type S. epidermidis 1457 or its isogenic PIA/HA-negative mutant. The wild-type strain was significantly more likely to cause a subcutaneous abscess than the mutant strain (P < 0.01) and was significantly less likely to be eradicated from the inoculation site by host defense (P < 0.05). In addition, the wild-type strain was found to adhere to the implanted catheters more abundantly than the PIA/HA-negative mutant (P < 0.05). The reliability of the adherence assay was assessed by scanning electron microscopy. To exclude contamination or spontaneous infection, bacterial strains recovered from the experimental animals were compared to inoculation strains by analysis of restriction fragment length polymorphism patterns by pulsed-field gel electrophoresis. In vitro binding of the wild-type strain and its isogenic mutant to a fibronectin-coated surface was similar. These results confirm the importance of biofilm production, mediated by PIA/HA, in the pathogenesis of S. epidermidis experimental foreign body infection. (+info)

Characterization of Staphylococcus epidermidis polysaccharide intercellular adhesin/hemagglutinin in the pathogenesis of intravascular catheter-associated infection in a rat model. (7/4882)

Biofilm production is thought to be a crucial factor in the ability of Staphylococcus epidermidis to produce a biomaterial-based infection. A rat central venous catheter (CVC)-associated infection model was used to assess the importance of biofilm production, mediated by polysaccharide intercellular adhesin/hemagglutinin (PIA/HA), in the pathogenesis of intravascular catheter-associated infection. PIA/HA-positive S. epidermidis 1457 was significantly more likely to cause a CVC-associated infection (71 versus 14%, P < 0.03) resulting in bacteremia and metastatic disease than its isogenic PIA/HA-negative mutant. These results confirm the importance of biofilm production, mediated by PIA/HA, in the pathogenesis of S. epidermidis experimental CVC-associated infection. (+info)

Characterization of the relationship between polysaccharide intercellular adhesin and hemagglutination in Staphylococcus epidermidis. (8/4882)

To determine whether a relationship exists between biofilm formation and hemagglutination in Staphylococcus epidermidis, 20 skin isolates and 19 prosthetic valve endocarditis isolates were characterized for biofilm formation, hemagglutination, and the presence of a 357-bp polymerase chain reaction product within icaA. A strong association existed between biofilm formation, which has been linked to strains that produce polysaccharide intercellular adhesin (PIA), and hemagglutination. Strains that produced biofilm were significantly (P<.001) more likely to mediate hemagglutination (16 biofilm-positive/hemagglutination-positive strains and 19 biofilm-negative/hemagglutination-negative strains) within the 39 clinical strains tested. In addition, Staphylococcus carnosus TM300, a biofilm-negative, hemagglutination-negative strain, carrying the ica operon-containing plasmid pCN27, produced significant biofilm on glass and mediated hemagglutination (>/=1/128). It was concluded that production of PIA and hemagglutination are strongly associated and that PIA, at least in part, mediates hemagglutination in S. epidermidis. (+info)

For other species in disease-associated biofilms and biofilms arising from eukaryotes, see below. Biofilms have been found to ... may contribute to biofilm dispersal. Enzymes that degrade the biofilm matrix may be useful as anti-biofilm agents. Evidence has ... Drip Flow Biofilm Reactor® rotary devices (such as the CDC Biofilm Reactor®, the Rotating Disk Reactor, the Biofilm Annular ... Documentary on Biofilms: The Silent Role of Biofilms in Chronic Disease HD Video Interviews on biofilms, antibiotics, etc. with ...

https://en.wikipedia.org/wiki/Biofilm

In moving-bed biofilm reactors, biofilms grow on small plastic or sponge-based carriers that circulate in the bioreactors using ... Current challenges for biofilm-mediated bioremediation include difficulties in controlling the structure of the biofilm and, in ... Much research has been done on methods to remove biofilms in clinical and food manufacturing processes, but biofilms are also ... One method for treating dairy wastewater is using anaerobic biofilm reactors. The biofilm grows on a support material which can ...

https://en.wikipedia.org/wiki/Application_of_biofilms_in_industry

... many of which can be attributed to bacterial biofilms. There is much research into the prevention of biofilms. Biofilm ... They prevent biofilm formation by interfering with the attachment and expansion of immature biofilms. Typically, these coatings ... Other than chemicals, enzymes have been used to degrade the biofilm matrix and eject biofilm cells forcibly. First shown in P. ... C2D is a medium of fatty acid chain that effect on staphylococcus aureus biofilm and dispersion of these biofilm. Pseudomonas ...

https://en.wikipedia.org/wiki/Biofilm_prevention

These biofilms occur on contact surfaces in a range of terrestrial and aquatic environments. The formation of biofilms is a ... Additionally, because biofilm response to pollutants during initial exposure suggested acute toxicity, biofilms can be used as ... While some of the organisms contributing to the formation of the biofilms can be identified, exact composition of the biofilms ... using biofilms as compared to other floc materials. There are also many other benefits to using phototrophic biofilms in ...

https://en.wikipedia.org/wiki/Phototrophic_biofilm

A floc is a type of microbial aggregate that may be contrasted with biofilms and granules, or else considered a specialized ... Yeast flocculation#Process Davey ME, O'toole GA (December 2000). "Microbial biofilms: from ecology to molecular genetics". ... rather than attached to and growing on a surface like most biofilms. The floc typically is held together by a matrix of ... type of biofilm. Flocs appear as cloudy suspensions of cells floating in water, ...

https://en.wikipedia.org/wiki/Floc_(biofilm)

Biofilm prevention Biofilm factory Phototrophic biofilms Report on Research 1990, Montana State University (Report). pp. 10-11 ... to co-sponsor a one-day workshop on biofilms. The resulting workshop, "Biofilms, Medical Devices and Anti-Biofilm Technology: ... "Public Workshop - Biofilms, Medical Devices and Anti-Biofilm Technology - Challenges and Opportunities, February 20, 2014". ... The center's industrial focus expanded from biofilm control and mitigation to include positive use of biofilm processes to ...

https://en.wikipedia.org/wiki/Center_for_Biofilm_Engineering

The MBBR system is considered a biofilm process. Other conventional biofilm processes for wastewater treatment are called ... Moving bed biofilm reactor (MBBR) is a type of wastewater treatment process that was first invented by Prof. Hallvard Ødegaard ... Moving bed biofilm reactors have shown promising results to remove micropollutations (MPs) from wastewater. MPs fall into ... Falås, P.; Baillon-Dhumez, A.; Andersen, H. R.; Ledin, A.; la Cour Jansen, J. (2012-03-15). "Suspended biofilm carrier and ...

https://en.wikipedia.org/wiki/Moving_bed_biofilm_reactor

The rotating cell biofilm reactor (RCBR) is a new type of biological process based on biofilm active sludge used in wastewaters ... This biofilm system does not need any blower to oxygenate the bacteria colonies. It's the simple cell rotation to produce the ...

https://en.wikipedia.org/wiki/Rotating_cell_biofilm_reactor

Genetic approaches to study of biofilms". Biofilms. Methods in Enzymology. Biofilms. Vol. 310. Academic Press. pp. 91-109. doi: ... a TED-ED animation on biofilms Biofilm Up Close, FASEB Bioart Award-winning image in The Scientist in 2016 Turning Point: ... but the genetics of biofilm formation was unexplored and most microbiologists did not view biofilm formation as a physiological ... living within communities called biofilms). The lab popularized the concept of bacterial biofilm formation as developmental or ...

https://en.wikipedia.org/wiki/Roberto_Kolter

Biofilm is an aggregate of microorganisms in which cells adhere to each other or a surface. Bacteria in the biofilm community ... This system functions optimally when the S. mutans cells are in crowded biofilms. S. mutans cells growing in a biofilm are ... mutans in dental biofilms can be reduced or eliminated, the acidification potential of dental biofilms and later cavity ... This decreases the biofilm pathogenesis, and therefore its caries promoting potential. This offers the potential for an anti- ...

https://en.wikipedia.org/wiki/Streptococcus_mutans

Biofilms. Bacteria often attach to surfaces and form dense aggregations called biofilms, and larger formations known as ... These biofilms and mats can range from a few micrometres in thickness to up to half a metre in depth, and may contain multiple ... Biofilms are also important in medicine, as these structures are often present during chronic bacterial infections or in ... Bacteria living in biofilms display a complex arrangement of cells and extracellular components, forming secondary structures, ...

https://en.wikipedia.org/wiki/Bacteria

Some species of bacteria secrete it to form biofilms. Cellulose is the most abundant organic polymer on Earth. The cellulose ... Romeo, Tony (2008). Bacterial biofilms. Berlin: Springer. pp. 258-263. ISBN 978-3-540-75418-3. Klemm, Dieter; Heublein, ...

https://en.wikipedia.org/wiki/Cellulose

Pellicle is a variety of biofilm that is formed between the air and the liquid in which bacteria grow. In a biofilm, bacterial ... The biofilm needs bacterial cells to move in a certain manner, while flagella is the organelle which has locomotive function. ... Lemon, KP; Earl, AM; Vlamakis, HC; Aguilar, C; Kolter, R (2008). "Biofilm development with an emphasis on Bacillus subtilis". ... Bacterial Biofilms. Current Topics in Microbiology and Immunology. 2008: 1-16. doi:10.1007/978-3-540-75418-3_1. ISBN 978-3-540- ...

https://en.wikipedia.org/wiki/Shewanella_oneidensis

It may have potential in fighting biofilm implied in infectious diseases that are present in more than 60% of Hospital-acquired ... Marques, CN; Davies, DG; Sauer, K (2015). "Control of Biofilms with the Fatty Acid Signaling Molecule cis-2-Decenoic Acid". ... Davies, DG; Marques, CN (2009). "A fatty acid messenger is responsible for inducing dispersion in microbial biofilms". Journal ... Bryers, JD (2008). "Medical biofilms". Biotechnol. Bioeng. 100 (1): 1-18. doi:10.1002/bit.21838. PMC 2706312. PMID 18366134. v ...

https://en.wikipedia.org/wiki/Cis-2-Decenoic_acid

A biofilm is a community of microorganisms adsorbed to a surface. Microorganisms in biofilms are enclosed in a polymeric matrix ... Biofilms on food processing surfaces can be a biological hazard to food safety. Increased chemical resistance in biofilms can ... Biofilms form on solid substrates such as stainless steel. A biofilm's enclosing polymeric matrix offers protection to its ... Tarver, Toni (2009). "Biofilms: A Threat to Food Safety". Food Technology. 63 (2): 46-52. Visser, J; Jeurnink, Th. J. M (1997 ...

https://en.wikipedia.org/wiki/Protein_adsorption_in_the_food_industry

biofilm. December 15, 2012. "Dr. Bill Costerton: Diagnosing and Treating Biofilm Infections". YouTube. biofilm. April 16, 2013 ... Bill Costerton - The "Father" of Biofilms". YouTube. biofilm. April 24, 2012. "Doctors' Bill Costerton and Randy Wolcott: The ... There he and his team did research on biofilms involved in periodontal disease. In 2008 he became the director of biofilm ... He is sometimes referred to as the "Father of Biofilms" or the "King of Slime". J. William Costerton grew up in Vernon, British ...

https://en.wikipedia.org/wiki/J._William_Costerton

Kumamoto, Carol A. (2006). "Candida albicans Biofilms Produce Antifungal-Tolerant Persister Cells". Antimicrobial Agents and ... "Candida biofilms". Current Opinion in Microbiology. 5 (6): 608-611. doi:10.1016/S1369-5274(02)00371-5. PMID 12457706. ...

https://en.wikipedia.org/wiki/Carol_Kumamoto

Such C. albicans biofilms may form on the surface of implantable medical devices or organs. In these biofilms it is often found ... The biofilm of C. albicans is formed in four steps. First, there is the initial adherence step, where the yeast-form cells ... Zago CE, Silva S, Sanitá PV, Barbugli PA, Dias CM, Lordello VB, Vergani CE (2015). "Dynamics of biofilm formation and the ... Zap1 controls the equilibrium of yeast and hyphal cells, the zinc transporters and zinc regulated genes in biofilms of C. ...

https://en.wikipedia.org/wiki/Candida_albicans

When such communities are encased in a stabilizing polymer matrix ("slime"), they may be called "biofilms". Cells in biofilms ... Costerton JW (2007). "Direct Observations". The Biofilm Primer. Springer Series on Biofilms. Vol. 1. Berlin, Heidelberg: ... Bacterial biofilms may be 100 times more resistant to antibiotics than free-living unicells and may be nearly impossible to ... Biofilms may be highly heterogeneous and structurally complex and may attach to solid surfaces, or exist at liquid-air ...

https://en.wikipedia.org/wiki/Prokaryote

Coli Biofilms". ACS Nano. 11 (10): 9968-9978. doi:10.1021/acsnano.7b04128. hdl:2445/123493. PMID 28933815. Akolpoglu, Mukrime ...

https://en.wikipedia.org/wiki/Biohybrid_microswimmer

Coli Biofilms". ACS Nano. 11 (10): 9968-9978. doi:10.1021/acsnano.7b04128. hdl:2445/123493. PMID 28933815. Harris, Elizabeth H ...

https://en.wikipedia.org/wiki/Protist_locomotion

The biofilm formation is the main cause of Staphylococcus implant infections. Biofilms are groups of microorganisms, such as ... A class of enzymes have been found to have biofilm matrix-degrading ability, thus may be used as biofilm dispersal agents in ... A higher mortality is linked with multispecies biofilms. S. aureus biofilm is the predominant cause of orthopedic implant- ... aureus biofilms contain PIA. S. aureus biofilms are important in disease pathogenesis, as they can contribute to antibiotic ...

https://en.wikipedia.org/wiki/Staphylococcus_aureus

"Bacteriophages and Biofilms". Antibiotics. 3 (3): 270-284. doi:10.3390/antibiotics3030270. PMC 4790368. Patrick Jault; Thomas ...

https://en.wikipedia.org/wiki/Phagoburn

It allows other bacteria to bind to the already existing biofilm, creating a multilayer biofilm. Such biofilms decrease the ... Biofilms Microbiology Staphylococcus Schleifer, K. H.; Kloos, W. E. (1 January 1975). "Isolation and Characterization of ... As mentioned above, S. epidermidis causes biofilms to grow on plastic devices placed within the body. This occurs most commonly ... Moreover, S. epidermidis biofilm formation by releasing the exopolysaccharide intercellular adhesion (PIA) provides the ...

https://en.wikipedia.org/wiki/Staphylococcus_epidermidis

... npj Biofilms and Microbiomes. 8 (1): 1-11. doi:10.1038/s41522-022-00338-4. ISSN 2055-5008. PMC 9576740. PMID 36253412. Caputo, ...

https://en.wikipedia.org/wiki/Akkermansia_muciniphila

Silveira CB, Rohwer FL (2016-07-06). "Piggyback-the-Winner in host-associated microbial communities". npj Biofilms and ...

https://en.wikipedia.org/wiki/Kill_the_Winner_hypothesis

NPJ Biofilms and Microbiomes. 4 (1): 14. doi:10.1038/s41522-018-0057-2. PMC 6031612. PMID 30002868. Bergquist PR (1998). " ...

https://en.wikipedia.org/wiki/Sponge

... npj Biofilms and Microbiomes. 4 (1): 14. doi:10.1038/s41522-018-0057-2. PMC 6031612. PMID 30002868. Into the Brain of Comb ...

https://en.wikipedia.org/wiki/Ctenophora

Biofilm structures that are formed in simulation can be viewed as a movie using POV-Ray files that are generated as the ... This study explored the hypothesis that poor plasmid spread in biofilms is caused by a dependence of conjugation on the growth ... iDynoMiCS can be used to seek to understand how individual microbial dynamics lead to emergent population- or biofilm-level ... Through simulation, the paper suggests that plasmid invasion into a resident biofilm is only limited when plasmid transfer ...

https://en.wikipedia.org/wiki/Agent-based_model_in_biology

2016). "Spatio-temporal assembly of functional mineral scaffolds within microbial biofilms". npj Biofilms and Microbiomes. 2: ... The term biofilm refers to complex heterogeneous structures comprising different populations of microorganisms that attach and ... It uses the polymers produced by single cells during biofilm formation as a physical cue to coordinate ECM production by the ... Palmer J, Flint S, Brooks J (September 2007). "Bacterial cell attachment, the beginning of a biofilm". Journal of Industrial ...

https://en.wikipedia.org/wiki/Biomineralization

This review emphasizes Candida spp.-bacteria biofilms, the epidemiology of this community, the challenges in the eradication of ... This refractory effect is particularly critical in polymicrobial biofilms involving both fungi and bacteria. ... The ability to form biofilms is a common feature of microorganisms, such as bacteria or fungi. These consortiums can colonize a ... albicans biofilms were inferior than that in the mixed biofilms. Plus, the growth speed in the mixed biofilms was greater than ...

https://www.mdpi.com/2309-608X/6/1/5

See the BIOFILMS homepage at http://www.im.dtu.dk/biofilms for info on how to (un)subscribe and post to the Biofilms newsgroup ... Dear All, As a first pass at Bob MacLeans challenge for a definition of a biofilm.... Biofilm is useful as a general ... Biofilms definition?. Tim Charlton t.charlton at unsw.edu.au Tue Jul 20 10:06:22 EST 1999 *Previous message: Hiding the ... I think that it would be a red herring to try and give biofilm a definition that is narrow, being restricted to just one or a ...

http://www.bio.net/bionet/mm/biofilms/1999-July/000461.html

Biofilms are a well-characterized mode of microbial growth of both single and multi-species populations. They are associated ... Biofilms and the Skin Microbiome: A Hot Spot for Personal Care. Jan 3rd, 2020 ... The following is a collection of insights from academic partners of the UK-based National Biofilms Innovation Centre (NBIC), ... A combined, more holistic understanding of the interaction between the microbiome and biofilms will, in the future, strengthen ...

https://www.cosmeticsandtoiletries.com/research/literature-data/article/21835666/biofilms-and-the-skin-microbiome-a-hot-spot-for-personal-care

... to be highly effective in killing bacteria that create harmful biofilms in pools, spas and jetted tubs and are a health risk in ... Biofilms. Bacterial biofilms are slime that may consist of several types of bacteria. One common example of a biofilm is the ... There is a complex method, or order, in the formation of a bacterial biofilm. Biofilms start with an individual bacterium or ... Polysaccharide matrixes also form a protective barrier for organisms within the biofilm. Biofilms are not just limited to ...

https://wcponline.com/2006/08/27/aop-successfully-eliminates-biofilm-building-blocks-recreational-waters/

Here we investigate such an internal conflict within a microbial (Bacillus subtilis) biofilm community: cells in the biofilm ... suggesting new strategies to control biofilm growth. The emergence of long-range metabolic co-dependence within a biofilm ... As a result, biofilm growth halts periodically, increasing nutrient availability for the sheltered interior cells. We show that ... During growth in a biofilm, cells at the periphery protect interior cells from external attack but can also starve them through ...

https://www.nature.com/articles/nature14660.epdf?no_publisher_access=1&r3_referer=nature&error=cookies_not_supported&code=f64b2fe4-5688-4c03-9a71-4d597eed3c0c

Structural insights into the periplasmic sensor domain of the GacS histidine kinase controlling biofilm formation in ... A gacS mutant devoid of the periplasmic detector domain is severely defective in biofilm formation. Functional assays indicate ... Structural insights into the periplasmic sensor domain of the GacS histidine kinase controlling biofilm formation in ... Structural and functional insights into the periplasmic detector domain of the GacS histidine kinase controlling biofilm ...

https://www.rcsb.org/structure/5o7j

The emphasis on the role of biofilms in the pathogenesis of various microbial diseases, as well as discussions of biofilm ... Perez E, Williams M, Jacob JT, Reyes MD, Chernetsky Tejedor S, Steinberg JP, Microbial biofilms on needleless connectors for ... and dispersal of fungal and bacterial biofilms. The target audience is biofilm researchers, but this second edition of the book ... Microbial Biofilms is a useful compendium suitable for students and a practical guide for researchers investigating new biofilm ...

https://wwwnc.cdc.gov/eid/article/22/6/16-0282_article

Pharmaceuticals suppress algal growth and microbial respiration and alter bacterial communities of stream biofilms. ... Pharmaceuticals suppress algal growth and microbial respiration and alter bacterial communities of stream biofilms. ...

https://lternet.edu/biblio/pharmaceuticals-suppress-algal-growth-and-microbial-respiration-and-alter-bacterial-communities-of-stream-biofilms/

The overall goal of their research is to identify factors to control and manage biofilms and their extraordinary resistance to ... They are specifically interested in differential gene expressions coinciding with the formation and dispersion of biofilms, the ... and the mechanism by which biofilm cells gain their heightened resistance to antimicrobial agents. ... elucidate regulatory and signaling events underlying the formation and development of highly antimicrobial resistant biofilms. ...

https://www.binghamton.edu/centers/biofilm-research/profile.html?id=ksauer

Chapter Four focuses on biofilm development, its impact on human health and the problems that are associated with biofilm ... Biofilms are naturally occurring clusters of microorganisms that stick to non-biological surfaces, like rocks in a stream. This ... Chapter 4. Microbial Biofilm: Serious Threat to Human Health. (Aisha Waheed Qurashi, Beenish Sarfraz, Iram Liaqat, Mehwish ... Home / Shop / Newly Published Books / Engineering & Technology / Biofilms: Advances in Research and Applications. ...

https://novapublishers.com/shop/biofilms-advances-in-research-and-applications/

The UKs world-class expertise in the research of biofilms has been recognised through the launch of a new National Biofilms ... National Biofilms Innovation Centre. The UKs world-class expertise in the research of biofilms has been recognised through the ... The UKs world-class expertise in the research of biofilms has been recognised through the launch of a new National Biofilms ... Research here ranges from studying biofilms in rivers, through using biofilms to improve stress resistance of biocatalysis, to ...

https://www.birmingham.ac.uk/news/2017/national-biofilms-innovation-centre-1

We measured DIN uptake by biofilms in artificial flumes in each stream, using separate 15N-NO3− and 15N-NH4 additions in a ... Our study also shows that DIN uptake by benthic biofilms varies with DIN availability and with DIN speciation, which often is ... We aimed to evaluate how biofilms from 2 streams differing in background DIN concentration would respond to increases in ... Together, these results indicate that the response capacity of biofilm communities to short-term increases of DIN concentration ...

https://bioone.org/journals/freshwater-science/volume-32/issue-4/12-209.1/Influence-of-nitrate-and-ammonium-availability-on-uptake-kinetics-of/10.1899/12-209.1.short

... aeruginosa biofilms. To determine this capability, transport efficiencies of fluorescent-labeled magnetic nanoparticles on the ... aeurginosa biofilm can be achieved. Thicker biofilms will decrease the diffusion of antibiotics, in turn exposing the ... Biofilms represent formidable barriers to both the bodys own defenses and anti-microbial therapeutic agents. These polymeric ... The function of the biofilm for the inhabiting bacteria is multifaceted but includes the ability to reduce opsonization and ...

http://www.igert.org/highlights/160.html

... whereas PIA-independent biofilms showed enhanced biofilm formation. There was no correlation between the extent of biofilm ... the majority of isolates were categorized as moderate biofilm producers. Twelve isolates displayed PIA-independent biofilm ... In conclusion, nucleic acids and proteins formed the main components of the MRSA clone t127 biofilm matrix, and there seems to ... The presence of exopolysaccharides, proteins, and extracellular DNA and RNA in biofilms was assessed by a dispersal assay. In ...

https://www.hindawi.com/journals/bmri/2016/4708425/

... substrate metabolism by biofilm-bound cells and transport of products our of the biofilm 9)biofilm removal by detachment or ... Biofilm Ecosystem Development Coaggregation and Aggregation. Subsection 1a. Subsection 1b. Quorum Sensing. Subsection 1a. ... Intercellular Communication within Biofilm Communities. Cell-to-Cell Communication. Subsection 1b. Extrcellular Polymeric ... Biofilm formation 1)pre-conditioning of the adhesion surface 2)transport of planktonic celss from the bilk liquid to the ...

https://microbewiki.kenyon.edu/index.php?title=Biofilms_on_food_preparation_surfaces&oldid=49503

Moving Bed Biofilm Reactors upgrade existing industrial wastewater treatment facilities for overloaded, non-performing, and/or ... IDEAL MBBR™ Moving Bed Biofilm Reactors World Water Works, Inc.s IDEAL MBBR™ Moving Bed Biofilm Reactors upgrade existing ... IDEAL MBBR™ Moving Bed Biofilm Reactors -- Environmental Protection" /> .footer .footerProductLogos li {margin: 0px;display: ...

https://eponline.com/Directory/2014/01/IDEAL-MBBR-Moving-Bed-Biofilm-Reactors.aspx

Biofilm formation by bacteria protects them against environmental stresses such as desiccation, shear forces and antimicrobial ... The Effects of Subcellular Nanograting Geometry on the Formation and Growth of Bacterial Biofilms. ... The Effects of Subcellular Nanograting Geometry on the Formation and Growth of Bacterial Biofilms https://www.embs.org/tnb/wp- ...

https://www.embs.org/tnb/articles/tag/biofilm/

... the role of bacteriocins in shaping oral biofilms will be investigated by moving a Spanish researcher currently working in ... The role of bacteriocins in biofilm formation. Bacteriocins are a group of antimicrobial peptides produced by bacteria as a ... researchers will explore the role of bacteriocin immunity genes in bacteria interacting during biofilm formation. Moreover, ...

https://cordis.europa.eu/project/id/101029099

A study of the interactions between glass-ionomer cement and S. sanguis biofilms. ...

https://www.proquest.com/openview/922afa812df55ea1f95049915676b451/1?pq-origsite=gscholar&cbl=2026366&diss=y

... J Leukoc Biol. 2019 ... Conversely, topical application of α-mannosidases reduced bacterial biofilms and burden of infected corneas. Cumulatively, ... these data suggest novel therapeutic approaches to control bacterial biofilm assembly and improve bacterial clearance via ...

https://pubmed.ncbi.nlm.nih.gov/30690787/

Menaquinones effect on biofilm formation on fibronectin-coated surfaces appears to be regulated by sarA. These findings are ... Menaquinone at physiologic levels (0.01 μg/ml MH) significantly increased (p 0.05) biofilm formation on plastic in a manner ... In addition, menaquinone (0.05 - 4 μg/ml) significantly increased (p 0.05) biofilm formation on fibronectin-coated surfaces for ... biofilm formation (plastic and fibronectin-coated microtiter plates) and carotenoid levels were determined ...

https://www.scirp.org/journal/paperinformation.aspx?paperid=43928

New enzyme technology that prevents formation of and causes breakdown of microbial biofilm in tissues could help combat ... Addressing Microbial Biofilm to Combat Infections - The Way Forward. The biofilm forms a sticky coating on the surface of ... What is Biofilm?. Microbial biofilm is a slimy sticky substance secreted by microorganisms such as bacteria and fungi to ... Biofilms May Be Responsible for Skin Diseases Becoming Chronic. Research into the molecular mechanism of biofilm formation, ...

https://www.medindia.net/news/healthinfocus/addressing-microbial-biofilm-to-combat-infections-the-way-forward-171103-1.htm

Biofilms -- microbial communities that form slimy layers on surfaces -- are difficult to treat and remove, often because the ... The team then added the T-Budbots to bacterial biofilms in dishes and magnetically steered them. The microbots penetrated the ... Degraded remnants of the biofilm adhered to the microbots surfaces. The researchers note that this was a proof-of-concept ... "Magnetotactic T-Budbots to Kill-n-Clean Biofilms". ACS Applied Materials & Interfaces ...

https://www.acs.org/content/acs/en/pressroom/presspacs/2020/acs-presspac-september-23-2020/magnetic-t-budbots-made-from-tea-plants-kill-and-clean-biofilms-video.html

MagWeb presents Camille Keaton bio, films, age, & posts in twitter. Camille Keaton profile updated daily

http://www.magweb.com/actors/camille_keaton

Biofilm Buster Pro is the answer to your biofilm problems. It uses bio-enzymes to actively digest all the layers of biofilm and ... Biofilm Buster Pro can rid you of your slimy mess and restore your system to 100% capacity. In addition, because extended ... When the system is turned off, the biofilm settles and forms clumps. When the system is turned back on, the process begins ... Acid treatments kill the biofilm, but they also kill beneficial bacteria and can harm the plants, meaning they can only be used ...

https://www.arbico-organics.com/product/biofilm-buster-pro-enzymes/cleaning-disinfecting-organically

Disturbance During Biofilm Community Succession Promotes Cooperation and Diversity. James P. Stratford, Douglas M. Hodgson, ... Disturbance During Biofilm Community Succession Promotes Cooperation and Diversity Message Subject (Your Name) has forwarded a ...

https://www.biorxiv.org/content/10.1101/352914v1.article-metrics

Biofilm formation - Pseudomonas aeruginosa - Reference pathway [ Pathway menu , Organism menu , Pathway entry , Show ... Titration of RsmA induces the production of sessile and biofilm determinants, whereas free RsmA leads to a planktonic and more ... It is demonstrated that the accumulation of cAMP inhibits the attachment phase of biofilm formation. The QS systems are ... The main key actors relevant in the regulation of biofilm formation by Pseudomonas aeruginosa include cAMP/Vfr signaling, ...

https://www.genome.jp/kegg-bin/show_pathway?map02025+K13060

This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization ...

https://www.empr.com/manufacture/biofilm-inc/

... forming a slimy and slippery layer known as biofilm. Bacterial biofilms are complex microbial communities protected by an ... The extracellular matrix improves biofilm cohesion and its adhesion to surfaces. ... Understanding biofilms is necessary to prevent infections. Studying biofilms is necessary in order to find innovative and more ... Biofilms forming on catheters can provoke urinary-tract infections. Biofilms on joint implants pose a particular threat, since ...

https://blog.oup.com/2018/01/biofilms-bacteria-threat-for-medical-devices/

Persons tagged with «Biofilm». Name. Phone. E-mail. Tags. Junges, Roger Associate Professor +47 22840340 [email protected] ... microbiology, streptococci, genetic competence, signalling, biofilm, commensals, pathogens Simm, Roger Head of Department +47 ... Biofilm, microbial diagnostics, protein purification, Microbiology, DNA-isolation, signalling, 16S rRNA sequencing ... Biofilm, Antimicrobial resistance, Host-microbe interactions, Microbe-microbe interactions, Virulence, Molecular microbiology, ...

https://www.nhm.uio.no/?vrtx=tags&tag=Biofilm&resource-type=person&areacode=900000&lang=en

Point mutations in a putative ligand binding pocket lined by positively-charged residues originating primarily from the major loop impaired biofilm formation. (rcsb.org)

The ability to form biofilms is a common feature of microorganisms, such as bacteria or fungi. (mdpi.com)
Twenty-five methicillin-resistant Staphylococcus aureus (MRSA) isolates were characterized by staphylococcal protein A gene typing and the ability to form biofilms. (hindawi.com)
We examined this issue in terms of observation of the growth properties and ability to form biofilms in sensitive S. aureus and MRSA after the application of antibiotics (ATBs)-ampicillin, oxacillin and penicillin-and complexes of selenium nanoparticles (SeNPs) with these ATBs. (muni.cz)
C. albicans has the ability to form biofilms and morphogenetic conversions between yeast and hyphal morphologies contribute to biofilm development and represent an essential virulence factor. (altmetric.com)

There is a complex method, or order, in the formation of a bacterial biofilm. (wcponline.com)
Within a short time, bacteria may accumulate in the plumbing of any improperly sanitized pool, spa or tub, thus resulting in the formation of a biofilm. (wcponline.com)
Microbial Biofilms provides an overview of the formation, structure/architecture, cell-to-cell interactions, and dispersal of fungal and bacterial biofilms. (cdc.gov)
A new approach to mitigate biofilm formation on totally implantable venous access ports. (cdc.gov)
Pseudomonas aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infections and has developed resistance mechanisms due to its ability to promote biofilm formation and evade host adaptive immune responses. (rcsb.org)
A gacS mutant devoid of the periplasmic detector domain is severely defective in biofilm formation. (rcsb.org)
These results demonstrate the functional role of GacS PD , evidence critical residues involved in GacS/GacA signal transduction system that regulates biofilm formation, and document the evolutionary diversity of the PDC/PAS domain fold in bacteria. (rcsb.org)
Sauer's research group utilizes the model organism Pseudomonas aeruginosa to elucidate regulatory and signaling events underlying the formation and development of highly antimicrobial resistant biofilms. (binghamton.edu)
They are specifically interested in differential gene expressions coinciding with the formation and dispersion of biofilms, the role of posttranslational modifications in enabling bacteria to sense and respond to environmental conditions, and the mechanism by which biofilm cells gain their heightened resistance to antimicrobial agents. (binghamton.edu)
At the University of Birmingham, we will use the Centre to develop a number of products that could be revolutionary, from new smart nanomaterials that release antimicrobials when triggered by environmental conditions, to novel light and photonic therapies and laser texturing of surfaces to prevent biofilm formation. (birmingham.ac.uk)
Twelve isolates displayed PIA-independent biofilm formation, while the remaining 13 isolates were PIA-dependent. (hindawi.com)
PIA-dependent biofilms showed variable dispersal after sodium metaperiodate treatment, whereas PIA-independent biofilms showed enhanced biofilm formation. (hindawi.com)
There was no correlation between the extent of biofilm formation or biofilm components and the adhesion or cohesion abilities of the bacteria, but the efficiency of adherence to glass beads increased after biofilm depletion. (hindawi.com)
These infections can complicate treatments involving in-dwelling catheters and medical implants through biofilm formation [ 2 ]. (hindawi.com)
18 ] observed that although the ica locus is present and expressed in PIA-independent biofilms, the genes do not appear to be involved in their formation. (hindawi.com)
By combining experimental methods and bioinformatics, researchers will explore the role of bacteriocin immunity genes in bacteria interacting during biofilm formation. (europa.eu)
Menaquinone at physiologic levels (0.01 μg/ml MH) significantly increased (p 0.05) biofilm formation on plastic in a manner that was bacterial population size dependent. (scirp.org)
In addition, menaquinone (0.05 - 4 μg/ml) significantly increased (p 0.05) biofilm formation on fibronectin-coated surfaces for four MSSA strains and one MRSA strain by two to six-fold as compared to medium controls. (scirp.org)
Menaquinone's effect on biofilm formation on fibronectin-coated surfaces appears to be regulated by sarA . (scirp.org)
Kirby, D. , Savage, J. and Plotkin, B. (2014) Menaquinone (Vitamin K2) Enhancement of Staphylococcus aureus Biofilm Formation. (scirp.org)
New enzyme technique that prevents formation as well as destroys formed biofilm improves treatment efficacy by exposing the organisms to antibiotics and host defense. (medindia.net)
Taking a cue from their observations, the team of scientists developed a technique to use the very same enzymes used by the bacteria to remodel the sugar armor, but to prevent formation and cause degradation of the biofilm and expose the organism to antibiotics and host defense in patients. (medindia.net)
Earlier attempts in combating biofilms were only partially successful in that they prevented biofilm formation. (medindia.net)
Surface colonization and subsequent biofilm formation and development provide numerous advantages to microorganisms. (genome.jp)
The main key actors relevant in the regulation of biofilm formation by Pseudomonas aeruginosa include cAMP/Vfr signaling, quorum sensing (QS) systems, Gac/Rsm pathway, and c-di-GMP signaling. (genome.jp)
It is demonstrated that the accumulation of cAMP inhibits the attachment phase of biofilm formation. (genome.jp)
In order to prevent infection, it is important to design surfaces that discourage bacterial adhesion and biofilm formation. (oup.com)
However, even a small number of bacteria adhering on a surface can initiate biofilm formation. (oup.com)
One important approach to studying bacterial adhesion and subsequent biofilm formation is the concept of bacterial surface sensing, i.e. the mechanisms that bacteria use to become aware of their adhering state. (oup.com)
A better understanding of bacterial surface sensing might suggest new ways to design "smart" surfaces that can't be sensed by bacteria and prevent or inhibit biofilm formation. (oup.com)
Skewness' is a roughness parameter that describes asymmetry in surface feature distribution and is thought to affect biofilm formation. (flow3d.com)
A fascinating thing about biofilm formation has to do with how the bacteria communicate. (zmescience.com)
However, the contributions of mechanics, while being central to the process of biofilm formation, have been overlooked as a factor influencing host physiology. (elifesciences.org)
Peipoch and fellow Associate Research Scientist Jinjun Kan, Ph.D. , who leads the Microbiology Group , are curious about the formation and function of biofilms. (stroudcenter.org)
Bacteria secrete proteins, polysaccharides, and other components to assemble a macromolecular matrix that surrounds cells to promote the formation of protective communities termed biofilms. (oist.jp)
This mini-symposium aims to provide a scientific platform and building opportunity, inviting the most prominent researchers to discuss their transformative new tools and unique approaches to manipulate biofilms, measure biofilm parameters, and leverage their emerging discoveries to influence biofilm formation. (oist.jp)
Importantly, each of the more biological researchers, for example, are eager to collaborate further with the more chemical and engineering-savvy researchers to define important biophysical aspects of bacterial adhesion and biofilm formation. (oist.jp)
The biofilm formation was intensely inhibited (up to 99% ± 7% for S. aureus and up to 94% ± 4% for MRSA) after application of SeNPs in comparison with bacteria without antibacterial compounds whereas ATBs without SeNPs inhibited S. aureus up to 79% ± 5% and MRSA up to 16% ± 2% only. (muni.cz)
Understanding the mechanisms of multi-species biofilm formation will facilitate the development of methods for combating bacterial biofilms in clinical, environmental, industrial, and agricultural areas. (dtu.dk)
This project will demonstrate how combination therapy can be used to effectively disrupt the formation of biofilm and eradicate underlying bacteria found in the lungs of cystic fibrosis patients, chronic urinary tract infections, diabetic leg wounds, burn wounds, dry and wet surfaces, the food industry and industrial oil, gas and water pipes," he said. (edu.au)
A phenotypic assay of C. albicans demonstrated a potent dose-dependent inhibitory effect of silver nanoparticles on biofilm formation, with an IC50 of 0.089 ppm. (altmetric.com)
Our results demonstrate that silver nanoparticles are potent inhibitors of C. albicans biofilm formation. (altmetric.com)
Furthermore, it was found that the antibacterial effect of TCDs lies in its ability to impair toxicity by inhibiting the major virulence factors and related genes involved in the biofilm formation of P. gingivalis , thus affecting the self-assembly of biofilm-related proteins. (dovepress.com)
The high-coverage approach allowed us to analyze over 398 million reads, revealing that microbial communities are individual-specific and no bacterial species was detected as key player at any time during biofilm formation. (biomedcentral.com)
The bacteria changing activity during biofilm formation and after meal ingestion were person-specific. (biomedcentral.com)
Thus, characterizing the composition of whole bacterial communities that actively engage in biofilm formation and sugar fermentation after the ingestion of food is vital for understanding community dynamics under health and disease conditions [ 7 ]. (biomedcentral.com)
Although the set of species present in the human oral biofilm is almost fully depicted, new efforts have to be conducted to establish microbial agonistic or antagonistic associations, to distinguish actively-growing bacteria from inactive or transient species, as well as to outline the role of individual species during biofilm formation on tooth surfaces. (biomedcentral.com)
The co-aggregation detected to occur between streptococci and Actinomyces species has been proposed to be a major promoter of human oral biofilm formation [ 8 ]. (biomedcentral.com)
In experiments with infectious Salmonella enterica serovar Typhimurium , which forms biofilms in the human intestinal tract and on medical devices, Tukel's team found that amyloid binding by 3H3 disrupted biofilm formation, causing the separation of bacterial cells within the film. (drugtargetreview.com)
Favorable conditions for biofilm formation are present if these structures and equipment are not cleaned for extended periods of time. (cdc.gov)
Heterotrophic plate counts and coliform counts, both of which are routinely run by the municipal water utility, will at least provide in indication of the potential for biofilm formation. (cdc.gov)
1450 Therefore, an increase in heterotrophic plate count would suggest a greater rate and extent of biofilm formation in a health-care facility water system. (cdc.gov)
The researchers have begun testing the technology on the surfaces of other metals and polymers that are used to reduce risks of bacterial growth and biofilm formation on devices such as orthopedic implants or wearable patches for chronic wounds. (techbriefs.com)
Together, they effectively inhibit odor-causing bacteria and reduce plaque biofilm formation by rendering plaque water soluable and unable to bind to the tooth. (entirelypets.com)
1-5 Dental units have unique characteristics that make them prone to biofilm formation. (cdc.gov)
ABSTRACT Objective to identify in the literature the biofilm formation and its behavior when faced with interventions in cutaneous wounds. (bvsalud.org)

Biofilms are naturally occurring clusters of microorganisms that stick to non-biological surfaces, like rocks in a stream. (novapublishers.com)
Microbial biofilm is a slimy sticky substance secreted by microorganisms such as bacteria and fungi to colonize and establish themselves on the surface of tissues, as well as on devices introduced into the body such as catheters, tubes, and implants such as heart valves, and artificial joints. (medindia.net)
The microorganisms that form biofilms include bacteria, fungi, and protists. (zmescience.com)
This slime - what scientists call biofilm - is a matrix of freshwater microorganisms, sand, and silt, and it makes up much of the biomass covering underwater surfaces in streams and rivers. (stroudcenter.org)
Kan explains, "We don't know how these microorganisms that make up biofilms form temporally and spatially and under what conditions. (stroudcenter.org)
Direct observation of a wide range of natural microorganisms has revealed the fact that the majority of microbes persist as surface-attached communities surrounded by matrix materials, called biofilms. (dtu.dk)
Microorganisms compete, cooperate, and communicate with each other in multi-species biofilms. (dtu.dk)
This graphic illustrates how swimming microorganisms cause the stretching of polymers in a mucus-like substance, attracting the motile cells to surfaces in biofilms. (medicaldesignbriefs.com)
Algae, protozoa, and fungi may be present in biofilms, but the predominant microorganisms of water system biofilms are gram-negative bacteria. (cdc.gov)
Biofilms are surface- adherent populations of microorganisms consisting of cells, water and extracellular matrix material Nanotechnology is promising field of science which can guide our understanding of the role of interspecies interaction in the development of biofilm. (who.int)

The following is a collection of insights from academic partners of the UK-based National Biofilms Innovation Centre (NBIC), which explores "hot spots" and opportunities related to this field. (cosmeticsandtoiletries.com)
The UK's world-class expertise in the research of biofilms has been recognised through the launch of a new National Biofilms Innovation Centre (NBIC). (birmingham.ac.uk)
This new National Biofilms Innovation Centre is poised to create a fusion of world-class interdisciplinary research and industry partnerships to deliver breakthrough science and technologies to control and exploit biofilms," said Jeremy Webb, Principal Investigator and Co-Director for NBIC. (birmingham.ac.uk)

Chapter 3 provides several animal models for the evaluation of fungal biofilms (primarily Candida spp. (cdc.gov)
I'd like to take something to speed the removal of biofilm, but per my anti-candida diet, I am not supposed to have any fermented foods. (planetthrive.com)
The opportunistic microbial pathogens Candida albicans and Staphylococcus aureus are among the most frequent causative agents of healthcare-acquired infections and are often co-isolated forming mixed biofilms, especially from contaminated catheters. (earthclinic.com)
Denture stomatitis: a role for Candida biofilms. (medscape.com)
Investigating dual-species candida auris and staphylococcal biofilm antiseptic challenge. (gcu.ac.uk)
Background: Candida infections are responsible for increased morbidity and mortality in immunocompromised patients, particularly when the Candida biofilm is composed of drug-resistant species. (uwc.ac.za)

In most cases, biofilm-associated infections are detected after the biofilms are already formed and can no longer be eliminated because of the tolerance of the biofilm to most antimicrobial treatments [ 4 ]. (hindawi.com)
Obviously the biofilm acts both as a physical and chemical barrier and poses a major challenge for successful eradication of hospital acquired infections such as urinary tract infections , lung infections ( pneumonia ) and bloodstream infections. (medindia.net)
Biofilm associated infections are associated with high rates of mortality and cause numerous deaths across North America each year. (medindia.net)
The biofilm consists of a matrix of sugar molecules such as galactosaminogalactan and Pel secreted by opportunistic pathogens such as Pseudomonas spp and Aspergillus spp which are associated with recurrent respiratory infections in persons with chronic lung diseases. (medindia.net)
Many hospital-acquired infections involve bacterial biofilms that form on catheters, joint prostheses, pacemakers and other implanted devices. (acs.org)
Medical-device related infections are often caused by biofilms forming on biomaterials inserted or implanted in the human body, such as catheters or joint implants. (oup.com)
Biofilms forming on catheters can provoke urinary-tract infections. (oup.com)
Studying biofilms is necessary in order to find innovative and more effective strategies to treat or prevent infections and bacterial persistence. (oup.com)
During chronic infections and in microbiota, bacteria predominantly colonize their hosts as multicellular structures called biofilms. (elifesciences.org)
It has been estimated that billions of dollars are spent every year worldwide to deal with damage to equipment, contaminations of products, energy losses, and infections in human beings resulted from microbial biofilms. (dtu.dk)
Novel solutions for biofilm infections are the focus of a collaborative research agreement between the University of Sydney, Whiteley Corporation and the Innovative Manufacturing Cooperative Research Centre. (edu.au)
As many important pathogenic bacteria produce curli or curli-like amyloids in their biofilms, including Escherichia coli , Staphylococcus aureus and Pseudomonas aeruginosa , this novel immunotherapy has the potential to be applied to a wide variety of infections. (drugtargetreview.com)
Although the association of biofilms and medical devices provides a plausible explanation for a variety of health-care associated infections, it is not clear how the presence of biofilms in the water system may influence the rates of health-care- associated waterborne infection. (cdc.gov)
They are also learning more about colonies of antibiotic-resistant bacteria, called biofilms, that are in the middle ears of most children who have multiple ear infections. (medlineplus.gov)

Here we show that biofilms of the pathogens Vibrio cholerae and Pseudomonas aeruginosa can induce large deformations of soft synthetic hydrogels. (elifesciences.org)
In this case, they illustrate how CA can interact with Pseudomonas aeruginosa, a bacteria (Germ), and together they can create an even stronger biofilm than either one alone! (earthclinic.com)
Polisacárido y copolímero lineal constituido principalmente por ácido D-manurónico con enlaces beta-1,4 y ácido L-glucurónico con enlaces alfa-1,4, presente en algas marinas tales como LAMINARIA y en BIOPELÍCULAS producidas por PSEUDOMONAS AERUGINOSA. (bvsalud.org)
A polysaccharide and linear copolymer, consisting mainly of beta-1,4-linked D-mannuronic acid and alpha-1,4-linked L-glucuronic acid, that occurs in marine algae such as LAMINARIA , and in BIOFILMS produced by PSEUDOMONAS AERUGINOSA . (bvsalud.org)

A vast number of pathogens are grouped as biofilms. (zmescience.com)
Dear Stephen, Do you feel that lyme bacterium and other pathogens are protected by biofilm layers and that must be treated simultaneously with herbs and/or antibiotics? (planetthrive.com)
Nanotechnology application includes 16 O/ 18 O reverse proteolytic labeling,use of quantum dots for labeling of bacterial cells, selective removal of cariogenic bacteria while preserving the normal oral flora and silver antimicrobial nanotechnology against pathogens associated with biofilms. (who.int)
In January 2021, the Department of Internal pathogens characterized as strong biofilm producers that Medicine - Infectious Disease and Infection Prevention are resistant to most antimicrobials. (who.int)

Biofilms -- microbial communities that form slimy layers on surfaces -- are difficult to treat and remove, often because the microbes release molecules that block the entry of antibiotics and other therapies. (acs.org)
Degraded remnants of the biofilm adhered to the microbots' surfaces. (acs.org)
It has been known for centuries that bacteria tend to adhere to solid surfaces, forming a slimy and slippery layer known as biofilm. (oup.com)
The extracellular matrix improves biofilm cohesion and its adhesion to surfaces. (oup.com)
In order to quantify the effects of skewness, well-defined positive and negative skew surfaces (Fig. 1, bottom right) were compared against the biofilm growth on a flat (non-skewed) surface. (flow3d.com)
Experimentally, it was found that negative skew surfaces show the highest rates of complete nitrification during biofilm growth. (flow3d.com)
Using DNA technology, Kan is measuring biofilm structure to see what kind of microbes assemble and when: "There are so many different types of bacteria, and probably only some of them, along with some algal cells, can attach to surfaces to begin creating a biofilm. (stroudcenter.org)
Biofilms can also be found on non-medical surfaces such as in pipes and on boat hulls, are expensive to remove and cause damage to surfaces. (edu.au)
Bacteria secrete a slimy substance that forms biofilms, allowing bacterial colonies to thrive on surfaces, including catheters, prosthetic valves, and other devices. (medicaldesignbriefs.com)
The engineers' findings reveal specifics about interactions that induce bacteria to swim close to surfaces, where they remain long enough to attach and form biofilms. (medicaldesignbriefs.com)
Micro-organisms inhabiting teeth surfaces grow on biofilms where a specific and complex succession of bacteria has been described by co-aggregation tests and DNA-based studies. (biomedcentral.com)
But can they be assured staff are consistently cleaning surfaces to remove stubborn biofilm that can hide harmful bugs residing within the biofilm? (healthybuildingsaustralia.com)
Most biofilms are formed within water, however recent studies have shown that biofilms also can be formed on dry surfaces, where they have quite different characteristics and survival performance. (healthybuildingsaustralia.com)
Research and testing has found biofilms (mostly containing superbugs) on nearly 90% of all high-touch objects and surfaces within intensive care units. (healthybuildingsaustralia.com)
The biofilms created by these microbes, on all sorts of surfaces, demonstrate a remarkable resistance to cleaning and disinfecting. (healthybuildingsaustralia.com)
We can train your staff to efficiently and effectively clean surfaces to reduce the likelihood of bugs hiding within a biofilm. (healthybuildingsaustralia.com)
it may produce a biofilm that promotes adhesion to the outer and inner surfaces of an urethral catheter. (medscape.com)

This refractory effect is particularly critical in polymicrobial biofilms involving both fungi and bacteria. (mdpi.com)
Biofilms are not just limited to bacteria: yeasts, fungi and protozoa are also common inhabitants. (wcponline.com)

A combined, more holistic understanding of the interaction between the microbiome and biofilms will, in the future, strengthen our understanding of the link between certain microbes and disease states. (cosmeticsandtoiletries.com)
Microbes use these enzymes to move sugar molecules around and cut them into pieces in order to build and remodel the biofilm matrix," says Dr. Sheppard, who is also a professor in the departments of Medicine and Microbiology and Immunology at McGill University. (medindia.net)
The outcome of the study indicates that glycoside hydrolases enzymes can break down the sugar matrix of the biofilm of diverse microbes and could be used as possible therapeutic agents to increase antibiotic efficacy and to weaken the virulence of the organism. (medindia.net)
Microbes too - they group together into communities called biofilms . (zmescience.com)
Essentially, how do the microbes get together to form biofilms? (stroudcenter.org)
In the field, microbes form synergistic biofilm consortia. (frontiersin.org)
Bacterial biofilms cause both human disease and death, and these microbes are also responsible for contamination in industrial and institutional settings," he said. (edu.au)

Protocols to evaluate biofilm control strategies in vivo are needed, since in vitro methods may not predict performance under the more robust conditions provided in an animal model ( 1 ). (cdc.gov)
Shayna McGill, an INCBN IGERT Trainee at the University of New Mexico, is investigating whether magnetic nanoparticles, under the influence of a static magnetic field, may be used to penetrate through an in vitro model of P. aeruginosa biofilms. (igert.org)
The biofilm dispersion is investigated in vitro using enzymatic detachment methods [ 20 ] and treatment with chemicals such as periodate (HIO 4 or NaIO 4 ). (hindawi.com)
Therefore, the purpose of this project was to establish an in vitro model of infective endocarditis to allow growth of bacterial biofilms on porcine aortic valves, serving as baseline for further research. (fu-berlin.de)
Conclusion: These results demonstrate the establishment of a novel in vitro model for bacterial biofilm growth on porcine aortic roots mimicking IE. (fu-berlin.de)
Several interventions were able to reduce and eliminate biofilm in in vitro and in vivo models. (bvsalud.org)

Polysaccharide matrixes also form a protective barrier for organisms within the biofilm. (wcponline.com)
The presence of deteriorating temporary soft denture lining material and an improperly matched cleanser (which generally is the case) is associated with an increased presence of candidal organisms within the biofilm. (medscape.com)

In conclusion, nucleic acids and proteins formed the main components of the MRSA clone t127 biofilm matrix, and there seems to be an association between adhesion and cohesion in the biofilms tested. (hindawi.com)
Polysaccharide intercellular adhesion- (PIA-) dependent biofilms are composed of poly- β -1,6-N-acetylglucosamine- (PNAG-) based matrices. (hindawi.com)
Moreover, bacteria within biofilms are significantly affected by matrix components that influence adhesion of the cells to solid substrata and cohesion between bacterial cells [ 23 ]. (hindawi.com)
By combining mechanical measurements and mutations in matrix components, we found that biofilms deform by buckling, and that adhesion transmits these forces to their substrates. (elifesciences.org)
The model will allow to identify predilection sites of valves for bacterial adhesion and biofilm growth and it may serve as baseline for further research on IE therapy and prevention, e.g. the development of antimicrobial transcatheter approaches to IE. (fu-berlin.de)

For example, bacteria within biofilms become aggregated together and are protected by a self-produced, slimy extracellular matrix comprised of various biopolymers. (cosmeticsandtoiletries.com)
Biofilm Buster Pro can rid you of your slimy mess and restore your system to 100% capacity. (arbico-organics.com)

I found particularly helpful the use of tolerance factors to compare reduced susceptibility of different biofilm-associated organisms toward biocides, antiseptics, and antibiotic drugs. (cdc.gov)
By drug loading these magnetic nanoparticles and causing triggered drug release from the nanoparticle surface, antibiotic penetration of P. aeurginosa biofilm can be achieved. (igert.org)
Therefore, distinct matrix layers representing subpopulations of bacteria are found in biofilms, resulting in different selective pressures and the emergence of antibiotic-resistant strains [ 6 - 8 ]. (hindawi.com)
Now, researchers reporting in ACS Applied Materials & Interfaces have made magnetically propelled microbots derived from tea buds, which they call "T-Budbots," that can dislodge biofilms, release an antibiotic to kill bacteria, and clean away the debris. (acs.org)
Combating biofilms using antibiotics and toxic chemicals can lead to the growth of antibiotic-resistant strains. (medicaldesignbriefs.com)
In these animals, 3H3 injections also led to biofilm dissociation and when followed by antibiotic therapy, allowed for the swift eradication of individual bacterial cells from the animals. (drugtargetreview.com)

This mini-symposium will bring together researchers from the fields of Biochemistry, Chemistry, Engineering, and Microbiology, all tackling major questions in bacterial biofilms. (oist.jp)

Other areas of strength include magnetic resonance imaging of molecular transport in biofilms, mixed fungal and bacterial biofilms, computational modelling and synthesis of peptides, polymers and nanomaterials to visualize or combat biofilms. (birmingham.ac.uk)
Another interesting observation was that the enzymes found in the bacteria were used against fungal biofilm, it successfully degraded the fungal biofilm as well, indicating cross-species activity . (medindia.net)
On the fungal pre-formed biofilm true hyphae was mostly absent, as filamentation was inhibited. (altmetric.com)
SEM observations are consistent with an overall loss of structure of biofilms mostly due to disruption of the outer cell membrane/wall and inhibition of filamentation.TEM indicates the permeabilization of the cell wall and subsequent disruption of the structural layers of the outer fungal cell wall. (altmetric.com)

Although the personal care industry focuses on healthy skin, understanding the role of biofilms in the pathogenesis and progression of acne and eczema should be of interest. (cosmeticsandtoiletries.com)
several of the contributions in this book specifically focus on the role of biofilms in disease processes (Chapters 6, 7, 8, 14, and 19) or biofilm susceptibility to antimicrobial agents (Chapters 2 and 13). (cdc.gov)
The emphasis on the role of biofilms in the pathogenesis of various microbial diseases, as well as discussions of biofilm tolerance and antimicrobial resistance should also be helpful and interesting to anyone working in the field of healthcare delivery. (cdc.gov)

Recently, specific types of biofilms containing ammonia-oxidizing bacteria have been identified in wastewater systems. (flow3d.com)
This study showed that NAC had fungistatic effects (inhibited the growth of the fungus) against both types of biofilms at high dose, but at a low dose, NAC actually had biofilm enhancing effects. (earthclinic.com)

This finding raises reflection on the part of nurses regarding the interventions adopted for the removal of biofilm. (bvsalud.org)

Most bacteria are present in biofilms, not as single-acting cells. (fruitofspirit.com)

Biofilm technology studies using modern scientific methods and equipment have resulted in a substantial improvement in understanding of the biological processes, structure, and function of biofilms. (elsevier.com)

Biofilms start with an individual bacterium or planktonic cell. (wcponline.com)
These planktonic cells may be thought of as the building blocks for biofilms. (wcponline.com)
Titration of RsmA induces the production of sessile and biofilm determinants, whereas free RsmA leads to a planktonic and more virulent lifestyle. (genome.jp)
High intracellular levels of c-di-GMP evoke the processes leading to the production of biofilm matrix, while a decrease in its level causes an increase in cell motility and transition into the planktonic forms of growth. (genome.jp)
Due to the protective role of the extracellular matrix, bacteria in a biofilm are more resistant to mechanical and chemical attacks than planktonic bacteria. (oup.com)
Experiments show that bacteria that are protected by biofilm are up to 1,000 times less susceptible to antibiotics than planktonic bacteria. (oup.com)
bacterial gene expression changes radically once bacteria form a biofilm, compared to the planktonic state. (oup.com)
It is well known that biofilm cells (sessile cells) are far more recalcitrant than planktonic cells. (frontiersin.org)
Organisms within biofilms behave quite differently than their planktonic (i.e., free floating) counterparts. (cdc.gov)
Research has shown that biofilm-associated organisms are more resistant to antibiotics and disinfectants than are planktonic organisms, either because the cells are protected by the polymer matrix, or because they are physiologically different. (cdc.gov)
In this way, most bacteria do not have this planktonic structure in the human body, but in small networks called biofilms. (fruitofspirit.com)

Bacterial biofilms are slime that may consist of several types of bacteria. (wcponline.com)
That slime on the surface of water, particularly ponds, is also biofilm. (zmescience.com)
Biofilms, especially in water systems, are not present as a continuous slime or film, but are more often scanty and heterogeneous in nature. (cdc.gov)
Operating and maintaining equipment to prevent slime (biofilm), organic debris, and corrosion. (cdc.gov)

Even though the individual that are on the move are not attached it is probably useful to consider them still part of the biofilm and the detachment/reattachment behaviour as a biofilm process. (bio.net)
However, many facets of biofilms remain poorly understood, namely the fate or particulate organic matter, dynamics and rate of biofilm detachment, and factors influencing concentration gradients external to the biofilm surface, to name a few. (elsevier.com)

Improved biofilm models can also lead to the development of strategies to prevent and inhibit biofilms associated with infectious disease or to harness advantages of the bacterial community lifestyle for biofilm-associated environmental and industrial applications. (oist.jp)
Importantly, the TCDs could penetrate the biofilms to further effectively inhibit the growth of P. gingivalis under the biofilms. (dovepress.com)

The anti-biofilm effects are via cell wall disruption. (altmetric.com)
Specific Anti-biofilm Activity of Carbon Quantum Dots by Destroying P. (dovepress.com)
Carbon quantum dots with various biomedical properties are considered to have great application potential in antibacterial and anti-biofilm treatment. (dovepress.com)
What Is An Anti Biofilm Supplement? (fruitofspirit.com)

Although the composition of oral biofilms is well established, the active portion of the bacterial community and the patterns of gene expression in vivo have not been studied. (biomedcentral.com)
We could identify some gene expression patterns characteristic for early and mature oral biofilms. (biomedcentral.com)
In addition to the specific set of gene functions overexpressed in early and mature oral biofilms, as detected through the short-reads dataset, the long-reads approach detected specific changes when comparing the metatranscriptome of the same individual before and after a meal, which can narrow down the list of organisms responsible for acid production and therefore potentially involved in dental caries. (biomedcentral.com)

Streptococcus mutans with other species of bacteria has been known to form dental biofilm. (who.int)
Objective: This study quantified dental biofilm through the Simplified Oral Hygiene Index (OHI-S), by Greene and Vermillion, in children with dental erosion, comparing them with children without this oral health condition. (bvsalud.org)
Dental biofilm. (bvsalud.org)

We will bring products to market through the development and application of innovative manufacturing technologies that improve biofilm removal - both in areas of medical importance to improve the lives of people worldwide, and in industry to achieve less waste in food production and savings in the cost of transported liquids. (edu.au)
Nevertheless, process designers exploit our newfound understanding to improve biofilm reactor and supporting control system designs. (elsevier.com)

Chapter Two discusses how to manage oral microbial biofilm using chemical and herbal medicine. (novapublishers.com)
Microbial biofilm research is now a feature of many scientific disciplines including biological sciences, medicine, chemistry, physics, computational modelling, engineering and ocean science. (birmingham.ac.uk)
Revolutionary enzymatic mechanism to tackle microbial biofilm has been developed by a research team led by the Research Institute of the McGill University Health Centre (RI-MUHC) and The Hospital for Sick Children. (medindia.net)

Biofilms on joint implants pose a particular threat, since it is difficult to eradicate biofilms with antibiotics, often necessitating additional surgery for implant removal and replacement. (oup.com)
There is great need for an immunotherapy that can be used alongside lower dose antibiotics or other antimicrobials to safely and effectively eradicate biofilms in infectious settings. (drugtargetreview.com)

The findings demonstrate a promising new method for improving the efficiency of periodontitis treatment by penetrating the P. gingivalis biofilm with preparations of nano-level antibacterial drugs. (dovepress.com)

World Water Works, Inc.'s IDEAL MBBR™ Moving Bed Biofilm Reactors upgrade existing industrial wastewater treatment facilities for overloaded, non-performing, and/or undersized systems. (eponline.com)
Researchers at the University of New Mexico conducted a series of experiments to understand the effects of surface roughness on annular nitrifying biofilm reactors (Roveto et al. (flow3d.com)
2011) and moving bed biofilm reactors (MBBRs, Song et al. (flow3d.com)
Annular biofilm reactors are made up of a cylindrical reactor with a submerged rotating inner cylinder - a standard Taylor-Couette flow setup (Fig. 1, bottom left). (flow3d.com)
2014). Because of this research, annular biofilm reactors are used with added skew to the inner cylinder of the reactor. (flow3d.com)
The application of biofilm mechanics and fundamental principles to understand biofilms and design biofilm reactors represents a paradigm shift from the historical approach, which was based on empirical criteria and design formulations. (elsevier.com)
While it is expected that the results of these studies can be used to improve the design and operation of biofilm reactors, there is a need to guide future research to the same end. (elsevier.com)
A basis for addressing this disconnection is presented by (1) describing the fundamental biofilm principles that can be uniformly applied to biofilms in several disciplines extending from medicine to environmental biotechnology, and (2) the presentation of a fundamental-based approach to understanding and applying biofilms in reactors. (elsevier.com)

19 ] found that deletion of the major autolysin ( atl ) gene in MRSA strains impaired their ability to form FnBP-dependent biofilms. (hindawi.com)
Oral bacteria form dental plaque, a biofilm discovered for the first time in the 17th century, when Antonie van Leeuwenhoek observed it with his rudimental microscope. (oup.com)
What are biofilms and how do they form? (zmescience.com)
Specifically, how biofilms form on soft, tissue-like materials remains unknown. (elifesciences.org)
By learning how biofilms form, scientists can also determine how they recover after destruction from flooding, how long it takes them to recover, and how to encourage recovery. (stroudcenter.org)
A form of amyloid called curli is secreted by bacterial cells and is a major component of biofilms. (drugtargetreview.com)
1438 It is inevitable that biofilms will form in most water systems. (cdc.gov)
1439 Biofilms may form under stagnant as well as flowing conditions, so storage tanks, in addition to water system piping, may be vulnerable to the development of biofilm, especially if water temperatures are low enough to allow the growth of thermophilic bacteria (e.g. (cdc.gov)
Because of the potential to form biofilm, CDC recommends that all dental unit waterlines be treated regularly with disinfectants to meet the Environmental Protection Agency (EPA) regulatory standards for drinking water (i.e., ≤500 colony forming units (CFU)/mL of heterotrophic water bacteria). (cdc.gov)
To form a biofilm, the bacteria first bind quickly to the surface and then build a polysaccharide structure that also. (fruitofspirit.com)

Here, we have expanded our observations to demonstrate that silver nanoparticles display dose-dependent activity against dual-species C. albicans/S. Aureus biofilms. (earthclinic.com)

Pilot tests for biofilm growth showed monospecies colonization consisting of cocci with time- and inocula-dependent increase after 24 h and 40 h (n = 4). (fu-berlin.de)
In n = 3 experiments for 24 h, with the same inocula, FISH visualized biofilms with ribosome-containing, and thus metabolic active cocci, tissue infiltration and similar colonization pattern as observed by the FISH in human IE heart valves infected by S. epidermidis. (fu-berlin.de)

The presence of exopolysaccharides, proteins, and extracellular DNA and RNA in biofilms was assessed by a dispersal assay. (hindawi.com)
Bacterial biofilms are complex microbial communities protected by an extracellular matrix composed of polysaccharides, proteins, and nucleic acids. (oup.com)
In this kind of MIC, cross-cell wall electron transport is required for SRB to utilize extracellular electrons released by Fe 0 oxidation in their cytoplasm for sulfate reduction, meaning that the biofilm must be electrogenic ( Gu, 2012 ). (frontiersin.org)

To create biofilms on porcine aortic valves the system was inoculated with Staphylococcus epidermidis PIA 8400. (fu-berlin.de)

With the exception of a brief discussion in Chapter 1, very little information is provided on the benefits and drawbacks of culture-independent methods to characterize clinically relevant biofilm communities. (cdc.gov)
These communities are called biofilms. (zmescience.com)
One of these complex communities is that found in the human oral dental plaque (hereinafter, human oral biofilm). (biomedcentral.com)
Biofilm microbial communities of denture stomatitis. (medscape.com)

In essence, the microbiome is the community of organisms present, and biofilms represent the habitat and biological environment in which the cells grow, evolve and adapt to their surroundings. (cosmeticsandtoiletries.com)

We were able to use the microbe's own tools against them to attack and destroy the sugar molecules that hold the biofilm together," says the study's co-principal investigator, Dr. Don Sheppard, director of the Division of Infectious Diseases at the MUHC and scientist from the Infectious Diseases and Immunity in Global Health Program at the RI-MUHC. (medindia.net)
Dr Manos, a Senior Lecturer in Infectious Diseases at the University, thanked the IMCRC and Whiteley Corporation and said the partnership would expand on the work of Dr Das, a University postdoctoral fellow who developed a three-part treatment to tackle bacterial biofilms called combination therapy. (edu.au)
Bacterial and infectious biofilms can be the reason. (fruitofspirit.com)

IE is characterized by bacterial biofilms of the endocardium, especially of the aortic and mitral valve leading to their destruction. (fu-berlin.de)

A biofilm is a community of bacterial cells in which cells stick to each other and to a surface. (flow3d.com)
According to this paper , a bacterial biofilm is defined as "a structured community of bacterial cells enclosed in a self-produced polymeric matrix and adherent to an inert or living surface. (zmescience.com)

Chapter 1 provides a balanced comparison of static and continuous flow methods for growing biofilms that should be beneficial for researchers investigating biofilm development or dispersion, and for applied studies evaluating new treatment strategies for biofilm prevention and control. (cdc.gov)

Biofilms are a well-characterized mode of microbial growth of both single and multi-species populations. (cosmeticsandtoiletries.com)
However, most natural biofilms are actually formed by multiple bacterial species. (dtu.dk)
The most recent advances in the understanding of multi-species biofilms are summarized and discussed in the review. (dtu.dk)

The permeability of the magnetic nanoparticles through the model alginate biofilm was enhanced 13.6 fold using an external magnetic field relative to the control (no magnetic field). (igert.org)
Fluorescent magnetic nanoparticles possessing different surface functional groups were individually evaluated for transport behavior in the alginate biofilm model. (igert.org)
Significant increases in transport rates of iron oxide nanoparticles through alginate biofilm were observed in the presence of a magnetic field. (igert.org)
Also silver nanoparticles demonstrated efficacy when tested against pre-formed C. albicans biofilms resulting in an IC50 of 0.48 ppm. (altmetric.com)

But in the wastewater treatment industry, biofilms can be harnessed to extract and digest organic compounds from sewage. (flow3d.com)
These nitrifying biofilms are used to improve the efficiency of the nitrification process in wastewater treatment systems. (flow3d.com)
This research suggests a method of increasing the efficiency of nitrifying biofilms in wastewater treatment plants. (flow3d.com)

However, to our knowledge this is the first study that has looked at the potential for magnetic nanoparticle to penetrate biofilms as carriers for drugs. (igert.org)
For instance, researchers are trying to develop antimicrobials that can penetrate deeper into a biofilm and for which antimicrobial resistance is less likely to arise. (oup.com)

For example, a search using PubMed for 2004-2016 identified 488 publications when using the search terms "biofilm and healthcare-associated infection" and 7,303 publications using the search terms "biofilm and public health," compared to 73 and 1,459 publications, respectively, for 1992-2003. (cdc.gov)
The research team studied the ways by which these two organisms formed the biofilm during the course of the infection. (medindia.net)
Biofilms can cause chronic infection and disease, and are difficult to eradicate, and are a problem in agriculture and medicine. (flow3d.com)
Finally, we demonstrate that V. cholerae biofilms can generate sufficient mechanical stress to deform and even disrupt soft epithelial cell monolayers, suggesting a mechanical mode of infection. (elifesciences.org)
If an epidemiologic investigation points to the water supply system as a possible source of infection, then water sampling for biofilm organisms should be considered so that prevention and control strategies can be developed. (cdc.gov)

Alarmingly the bugs hidden within the biofilms demonstrate an even greater capacity to resist antimicrobial treatments including antibiotics and disinfectants. (healthybuildingsaustralia.com)

In technical terms, bacterial biofilms are highly interactive, ubiquitous ecosystems consisting of individual bacterium bound to a foreign surface by a complex matrix. (wcponline.com)
The cells on the surface of the biofilm are aerobic, whereas those located deeper, where the oxygen concentration is low, are fermentative and dormant [ 4 , 5 ]. (hindawi.com)
The biofilm forms a sticky coating on the surface of tissues or implants and protects the underlying organisms from being acted on by host immune mechanisms or antimicrobial agents. (medindia.net)
Sometimes clumps of biofilm can break away from the main mass and establish themselves on a new surface. (zmescience.com)
When we go and clean the surface using normal cleaning methods, most of the transient bugs will be removed, but not the biofilm and not the resident bugs within the biofilm. (healthybuildingsaustralia.com)
This finding of the presence of dry surface biofilms has proved to be a worldwide problem. (healthybuildingsaustralia.com)
Independent tests have shown that bacteria in a dry surface biofilm have more than 1,000 times more resistance to chlorine disinfectants. (healthybuildingsaustralia.com)
Conclusion(s): the smartphones can serve as a fomite, considering that biofilms were detected on the surface of the films. (bvsalud.org)

The overall goal of their research is to identify factors to control and manage biofilms and their extraordinary resistance to antimicrobial agents. (binghamton.edu)
This book contains eight chapters that examine biofilms from a variety of perspectives, including the latest research in this field. (novapublishers.com)
Supported by a commitment of £26 million over the next 5 years, including £12.5M funding from the Biotechnology and Biological Sciences Research Council (BBSRC) and Innovate UK, with additional support from universities and industry, NBIC will bring the best of UK biofilm research together with UK companies from across multiple industry sectors to accelerate the adoption of new technologies into live products and services. (birmingham.ac.uk)
NBIC's inclusive model means that other universities and companies conducting biofilm research can participate and benefit from partnership with the NBIC consortium. (birmingham.ac.uk)
The UK is home to some of the most advanced research and commercial opportunities for the exploitation of biofilms so combining our talents gives us the best opportunity to establish a national, and international, agenda to tackle some of the world's biggest challenges and work seamlessly across academia and industry to stimulate growth in this vital area. (birmingham.ac.uk)
The University of Birmingham is already a major player in biofilm research in many different disciplines. (birmingham.ac.uk)
Research here ranges from studying biofilms in rivers, through using biofilms to improve stress resistance of biocatalysis, to investigating new ways to combat biofilms on medical devices or on human tissues, where they can cause serious health problems. (birmingham.ac.uk)
Without healthy biofilms, we don't have healthy streams," says Marc Peipoch, Ph.D. , who in February joined the Stroud Center as an assistant research scientist and the principal investigator of the Ecosystem Ecology Group . (stroudcenter.org)
In July, the research team placed sterilized rocks in several flumes in the Stroud Center's stream house and ran stream water from White Clay Creek through the flumes over the course of three weeks - the amount of time previous studies have shown it takes for biofilms to mature. (stroudcenter.org)
Through research at the interface of Biology, Chemistry, and Engineering, major advances are being introduced to transform qualitative descriptors of biofilms into fundamental and quantitative parameters connecting biofilm composition, structure, assembly and function. (oist.jp)
This chapter describes unifying biofilm principles that are of importance to both research as well as modern biofilm reactor design and operation. (elsevier.com)
Fundamental principles describing biofilms exist as a result of focused research. (elsevier.com)
Part I is dedicated to basic research and communicating the state of the art with respect to understanding biofilms. (elsevier.com)
New research by mechanical engineers at Purdue University, West Lafayette, IN, aims at fighting bacterial biofilms that can foul implantable medical devices. (medicaldesignbriefs.com)
The monoclonal antibody treatment detailed in this research loosens up the compact biofilms allowing for combination treatment. (drugtargetreview.com)

Chapter Four focuses on biofilm development, its impact on human health and the problems that are associated with biofilm control. (novapublishers.com)
Chapter Seven explains the concepts of biofilm development and the importance of honey and its implications in human health and disease control. (novapublishers.com)
Biofilm may be a potential protection factor against acid attacks and the development of dental erosion. (bvsalud.org)

In general, two biofilm phenotypes have been identified. (hindawi.com)
Some MRSA clinical isolates even produce biofilms of both phenotypes. (hindawi.com)
These three QS systems are involved in the regulation of virulence factor production, biofilm maturation, and motility phenotypes. (genome.jp)

In this subsequent study, they tested two different types of CA biofilms, one resistant to the antifungal, Fluconazole and one susceptible to Fluconazole. (earthclinic.com)
Biofilms protect bacteria from antibiotics and this can produce drug-resistant strains, especially the main pathogen of periodontitis, Porphyromonas gingivalis . (dovepress.com)
Bacteria within a biofilm can be 200 times more resistant to antibiotics. (healthybuildingsaustralia.com)

bacteria biofilms, the epidemiology of this community, the challenges in the eradication of such biofilms, and the most relevant treatments. (mdpi.com)
Acid treatments kill the biofilm, but they also kill beneficial bacteria and can harm the plants, meaning they can only be used before planting and after harvest. (arbico-organics.com)

Anatomy1

Organisms13

Diseases2

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes13

Disciplines and Occupations1

Technology, Industry, Agriculture6

Health Care4

Resistance of artificial biofilms of Pseudomonas aeruginosa to imipenem and tobramycin. (1/4882)

Vibrio cholerae O1 El Tor: identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation. (2/4882)

Surface-grafted, environmentally sensitive polymers for biofilm release. (3/4882)

Ultrasonic enhancement of antibiotic action on Escherichia coli biofilms: an in vivo model. (4/4882)

Study of the response of a biofilm bacterial community to UV radiation. (5/4882)

Characterization of the importance of polysaccharide intercellular adhesin/hemagglutinin of Staphylococcus epidermidis in the pathogenesis of biomaterial-based infection in a mouse foreign body infection model. (6/4882)

Characterization of Staphylococcus epidermidis polysaccharide intercellular adhesin/hemagglutinin in the pathogenesis of intravascular catheter-associated infection in a rat model. (7/4882)

Characterization of the relationship between polysaccharide intercellular adhesin and hemagglutination in Staphylococcus epidermidis. (8/4882)

Biofilms

Plankton

Staphylococcus epidermidis

Microbial Viability

Pseudomonas aeruginosa

Colony Count, Microbial

Bacterial Adhesion

Microscopy, Electron, Scanning

Candida albicans

Bacterial Physiological Phenomena

Streptococcus oralis

Microscopy, Confocal

Streptococcus mutans

Bacteria

Plasma Gases

Anti-Bacterial Agents

Microbial Interactions

Cetylpyridinium

Quorum Sensing

Peracetic Acid

Disinfectants

Gene Expression Regulation, Bacterial

Bacterial Proteins

Microbial Sensitivity Tests

Dental Plaque

Antifungal Agents

Chlorhexidine

Polysaccharides, Bacterial

Anti-Infective Agents, Local

Mouth

Staphylococcus aureus

Tobramycin

Equipment Contamination

Culture Media

Bioelectric Energy Sources

Bioreactors

Actinomyces

Farnesol

Water Microbiology

Microbial Consortia

Stainless Steel

Echinocandins

Fusobacterium nucleatum

Bacterial Load

Drug Resistance, Fungal

Biomass

Silicones

Catheter-Related Infections

Silicone Elastomers

Catheters

Polyvinyl Chloride

DNA, Bacterial

Tetrazolium Salts

Erythrosine

Streptococcus gordonii

Alginates

RNA, Ribosomal, 16S

Fluconazole

Drug Resistance, Bacterial

Candida

Polystyrenes

Shewanella

Antibiosis

Amphotericin B

Resistance of artificial biofilms of Pseudomonas aeruginosa to imipenem and tobramycin. (1/4882)

Vibrio cholerae O1 El Tor: identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation. (2/4882)

Surface-grafted, environmentally sensitive polymers for biofilm release. (3/4882)

Ultrasonic enhancement of antibiotic action on Escherichia coli biofilms: an in vivo model. (4/4882)

Study of the response of a biofilm bacterial community to UV radiation. (5/4882)

Characterization of the importance of polysaccharide intercellular adhesin/hemagglutinin of Staphylococcus epidermidis in the pathogenesis of biomaterial-based infection in a mouse foreign body infection model. (6/4882)

Characterization of Staphylococcus epidermidis polysaccharide intercellular adhesin/hemagglutinin in the pathogenesis of intravascular catheter-associated infection in a rat model. (7/4882)

Characterization of the relationship between polysaccharide intercellular adhesin and hemagglutination in Staphylococcus epidermidis. (8/4882)

The Roles of Glycerol in Candida Albicans Biofilm Formation and Invasi by Jigarkumar V. Desai

Biofilm formation on nanostructured hydroxyapatite-coated titanium. | NIOM

The role of the globin-coupled sensor YddV in a mature E. coli biofilm population - Institutional Repository University of...

Pseudomonas aeruginosa Promotes Escherichia coli Biofilm Formation in Nutrient-Limited Medium - Semantic Scholar

During the Early Stages of Staphylococcus aureus Biofilm Formation, Induced Neutrophil Extracellular Traps Are Degraded by...

IDEALS @ Illinois: Role of disinfectants and pipe materials on bacterial adhesion onto biofilms

Synergistic Effects in Mixed Escherichia coli Biofilms: Conjugative Plasmid Transfer Drives Biofilm Expansion | Journal of...

Abrasive treatment of microtiter plates improves the reproducibility of bacterial biofilm assays - RSC Advances (RSC Publishing)