WW: An isolated three-stranded antiparallel beta-sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state. (1/338)
The objective of this study was to evaluate the suitability of the WW domain as a desirable model system to understand the folding and stability of an isolated three-stranded antiparallel beta-sheet structure. The WW domain was subjected to thermal and chaotropic denaturation/reconstitution utilizing a variety of biophysical methods. This three-stranded sheet folds reversibly and cooperatively utilizing both urea and GdnHCl as denaturants; however, the denatured state retains structure in the form of a hydrophobic cluster involving at least one aromatic side chain. In contrast to chaotropic denaturation, thermal denaturation appears to be more complete and may be a two state process. The suitability of the WW domain for future studies aimed at understanding the kinetics and thermodynamics of antiparallel beta-sheet folding clearly emerges from this initial study. The most exciting and significant result in this manuscript is the finding that the chaotropic denatured state of WW has a hydrophobic cluster as discerned by near-UV CD evidence. The role that the denatured state plays in the folding and stability of a three-stranded beta-sheets, and its capacity for preventing aggregation may be particularly important and is the subject of ongoing studies. (+info)Detection of putative Zn(II) binding sites within Escherichia coli RNA polymerase: inconsistency between sequence-based prediction and 65Zn blotting. (2/338)
The availability of repeating 'Cys' and/or 'His' units in a particular order prompts the prediction of Zn(II) finger motifs in a protein. Escherichia coli RNA polymerase has two tightly bound Zn(II) per molecule of the enzyme as detected by atomic absorption spectroscopy. One Zn(II) was identified to be at the beta subunit, whereas the other putative Zn(II) binding site has recently been predicted to be at the N-terminal half of the beta' subunit, from primary sequence analysis. We show here that the beta' subunit has no ability to bind 65Zn(II). On the other hand, the N-terminal domain of the alpha subunit has strong Zn(II) binding ability with no obvious functional implications. (+info)Thiopental attenuates hypoxic changes of electrophysiology, biochemistry, and morphology in rat hippocampal slice CA1 pyramidal cells. (3/338)
BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects. We have examined how thiopental alters histological, physiological, and biochemical changes during and after hypoxia. These experiments should enable the discovery of agents that share some of the beneficial effects of thiopental. METHODS: We made intracellular recordings and measured ATP, sodium, potassium, and calcium concentrations from CA1 pyramidal cells in rat hippocampal slices subjected to 10 minutes of hypoxia with and without 600 micromol/L thiopental. RESULTS: Thiopental delayed the time until complete depolarization (21+/-3 versus 11+/-2 minutes for treated versus untreated slices, respectively) and attenuated the level of depolarization at 10 minutes of hypoxia (-33+/-6 versus -12+/-5 mV). There was improved recovery of the resting potential after 10 minutes of hypoxia in slices treated with thiopental (89% versus 31% recovery). Thiopental attenuated the changes in sodium (140% versus 193% of prehypoxic concentration), potassium (62% versus 46%), and calcium (111% versus 197%) during 10 minutes of hypoxia. There was only a small effect on ATP (18% versus 8%). The percentage of cells showing clear histological damage was decreased by thiopental (45% versus 71%), and thiopental improved protein synthesis after hypoxia (75% versus 20%). CONCLUSIONS: Thiopental attenuates neuronal depolarization, an increase in cellular sodium and calcium concentrations, and a decrease in cellular potassium and ATP concentrations during hypoxia. These effects may explain the reduced histological, protein synthetic, and electrophysiological damage to CA1 pyramidal cells after hypoxia with thiopental. (+info)Mitotic misregulation and human aging. (4/338)
Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process. (+info)Oestrogen, progesterone, and androgen receptors in ovarian neoplasia: correlation between immunohistochemical and biochemical receptor analyses. (5/338)
AIM: To investigate the correlation between immunohistochemical and biochemical steroid receptor analyses by measurement of oestrogen, progesterone, and androgen receptor status in ovarian neoplasia. METHODS: Tissue samples were obtained from 27 ovarian neoplasms, including two borderline tumours. Immunohistochemical staining of the tissue slides was scored semiquantitatively, incorporating the intensity and percentage of positive staining (histo-score). Tumours with a histo-score of 10 or more were considered steroid receptor positive. The epithelial and stromal fractions of the tumours were analysed separately. To study the uniformity of receptor expression throughout a tumour, up to four samples were analysed. RESULTS: Immunohistochemical histo-scores of the oestrogen receptor in the epithelial fractions were significantly correlated with the biochemical oestrogen receptor values (r = 0.408). Androgen receptor status in the epithelial fraction was correlated with that in the stromal fraction (r = 0.741), while androgen receptor histo-scores in the epithelial fraction correlated with the biochemical assay values (r = 0.463). On biochemical analysis, 17 of the 27 ovarian tumours were oestrogen receptor positive and seven were progesterone receptor positive. On immunohistochemical analysis, eight tumours were oestrogen receptor positive and two were progesterone receptor positive. Biochemical analysis showed that 14 of the 26 tumours were slightly androgen receptor positive (10-50 fmol/mg protein), while all the others were negative. On immunohistochemical analysis, seven of the 26 tumours were androgen receptor positive. When two or more specimens from one tumour were analysed, marked differences in steroid status were found, especially in progesterone receptor and androgen receptor expression. Some parts of a tumour were steroid receptor positive, while other parts were negative owing to heterogeneity of expression. CONCLUSIONS: Immunohistochemical and biochemical analysis of steroid receptors in ovarian tumours correlated weakly or not at all. Heterogeneity of expression within a tumour and the presence of progesterone and androgen receptors in the stromal fraction partly accounted for this observation. Biochemical and immunohistochemical androgen receptor status was much lower than in previous reports. (+info)Trehalose effect on low temperature protein dynamics: fluctuation and relaxation phenomena. (6/338)
We performed spectral diffusion experiments in trehalose-enriched glycerol/buffer-glass on horseradish peroxidase where the heme was replaced by metal-free mesoporphyrin IX, and compared them with the respective behavior in a pure glycerol/buffer-glass (Schlichter et al., J. Chem. Phys. 2000, 112:3045-3050). Trehalose has a significant influence: spectral diffusion broadening speeds up compared to the trehalose-free glass. This speeding up is attributed to a shortening of the correlation time of the frequency fluctuations most probably by preventing water molecules from leaving the protein interior. Superimposed to the frequency fluctuation dynamics is a relaxation dynamics that manifests itself as an aging process in the spectral diffusion broadening. Although the trehalose environment speeds up the fluctuations, it does not have any influence on the relaxation. Both relaxation and fluctuations are governed by power laws in time. The respective exponents do not seem to change with the protein environment. From the spectral dynamics, the mean square displacement in conformation space can be determined. It is governed by anomalous diffusion. The associated frequency correlation time is incredibly long, demonstrating that proteins at low temperatures are truly nonergodic systems. (+info)A new method for mapping nucleic acid sequence homology by electron microscopy. (7/338)
We describe here a new method for the electron microscopic mapping of sequence homology in nucleic acids. Specific segments of the T7 chromosome have been isolated following digestion with the restriction endonuclease from Hemophilus aegyptious (Haey). Denatured segments are annealed to the l-strand of T7 DNA; treatment of the hybrid with glyoxal allows only guanosine residues in the single-chain region to the reacted, producing an adduct which will no longer hydrogen bond with its complement on the r-strand. When the segment is displaced and the glyoxalated l-strand allowed to renature with the r-strand, "H" shaped structures are produced in which the duplex region corresponds to the position of sequence homology with the segment. The conditions employed for glyoxalation do not detectably disrupt duplex regions as small as 400 base pairs. This procedure should be generally useful for observing sequence homology in more complex DNA molecules containing duplex regions which can be specifically enriched for and their arrangement determined by electron microscopy. (+info)A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease. (8/338)
Most proteins essential for the biogenesis of peroxisomes (peroxins) that are identified to date are associated with or are integral components of the peroxisomal membrane. A prerequisite in elucidating their function is to determine their topology in the membrane. We have developed a novel tool to analyze the topology of peroxisomal membrane proteins in the yeast Hansenula polymorpha in vivo using the 27-kDa NIa protease subunit from the tobacco etch virus (TEVp). TEVp specifically cleaves peptides containing the consensus sequence, EXXYXQ downward arrowS (tev). We show that cytosolic TEVp and peroxisomal TEVp.SKL are selectively active on soluble cytosolic and peroxisomal tev-containing proteins in vivo, respectively, without affecting the viability of the yeast cells. The tev sequence was introduced in between the primary sequence of the peroxisomal membrane proteins Pex3p or Pex10p and the reporter protein enhanced green fluorescent protein (eGFP). Co-synthesis of these functional tev-GFP tagged proteins with either cytosolic TEVp or peroxisomal TEVp.SKL revealed that the C termini of Pex3p and Pex10p are exposed to the cytosol. Additional applications of the TEV protease to study peroxisome biogenesis are discussed. (+info)
Professional Medical Film
... biochemical phenomena illustrated by animation; laboratory technique of several Nobel prize winning scientists (40 min; color ...
Hypouricemia
Koretz RL (November 1981). "Hypouricemia--a transient biochemical phenomenon of total parenteral nutrition". Am. J. Clin. Nutr ...
Outline of natural science
History of environmental chemistry - history of the scientific study of the chemical and biochemical phenomena that occur in ... Environmental chemistry - Environmental chemistry is the scientific study of the chemical and biochemical phenomena that occur ... Environmental chemistry - scientific study of the chemical and biochemical phenomena that occur in natural places. ... history of the Environmental chemistry is the scientific study of the chemical and biochemical phenomena that occur in natural ...
Leo De Maeyer
... new technologies introduced and applications widened to important biochemical and biophysical phenomena. The Nobelprize ... The importance of this field for many fast biochemical processes was recognized very soon. Among many other applications, the ... Molecular acoustics, photon correlation studies of fluctuation phenomena, non-linear behaviour of matter in strong electric ... Journal of Biochemical and Biological Methods), (1981) Committee on Data for Science and Technology (CODATA), Interdisciplinary ...
Computer simulation
Phenomena in this category include genetic drift, biochemical or gene regulatory networks with small numbers of molecules. (see ... theories that involve continuous systems such as phenomena in physical cosmology, fluid dynamics (e.g., climate models, roadway ... "Molecular Simulation of Macroscopic Phenomena". Archived from the original on 2013-05-22. "Largest computational biology ...
Environmental chemistry
... is the scientific study of the chemical and biochemical phenomena that occur in natural places. It ... Chemical measures of water quality include dissolved oxygen (DO), chemical oxygen demand (COD), biochemical oxygen demand (BOD ...
Clinical neurochemistry
... is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic ... Sensitization, in the clinical sense of the word, is a phenomenon in which nociceptors in an area beyond a tissue injury ... The most basic and fundamental neurological phenomena in neuropharmacology is the binding of a drug or neurologically active ... Neurotransmitters and similarly functioning biochemical messengers elicit effects on postsynaptic neurons at neuronal synapses ...
Outline of chemistry
History of environmental chemistry - history of the scientific study of the chemical and biochemical phenomena that occur in ... Computational chemistry Environmental chemistry - study of chemical and biochemical phenomena that occur diverse aspects of the ... Mechanochemistry - coupling of mechanical and chemical phenomena on a molecular scale and can be seen as a coupling of ... History of mechanochemistry - history of the coupling of the mechanical and the chemical phenomena on a molecular scale and ...
Outline of physical science
History of environmental chemistry - history of the scientific study of the chemical and biochemical phenomena that occur in ... history of the Environmental chemistry is the scientific study of the chemical and biochemical phenomena that occur in natural ... History of quantum physics - history of the branch of physics dealing with physical phenomena where the action is on the order ... History of quantum mechanics - history of the branch of physics dealing with physical phenomena where the action is on the ...
Reductionism
In a biological context, this means attempting to explain all biological phenomena in terms of their underlying biochemical and ... sometimes to the extent of explaining phenomena at a given level of hierarchy in terms of phenomena at a higher level, in a ... Nobel laureate Philip Warren Anderson used the idea that symmetry breaking is an example of an emergent phenomenon in his 1972 ... Reductionism does not preclude the existence of what might be termed emergent phenomena, but it does imply the ability to ...
Electrophile
... been found between electrophilicity of various chemical compounds and reaction rates in biochemical systems and such phenomena ...
Solar Lake
A small lake of high salinity, it is the site of complex biochemical phenomena, linked to cycles of evaporation and of ... The Bear Lake in Sovata, Romania, is another example of this physical phenomenon. A solar pond is also a system for storing ...
Outline of Earth sciences
... history of the Environmental chemistry is the scientific study of the chemical and biochemical phenomena that occur in natural ... The scientific study of the chemical and biochemical phenomena that occur in natural places Environmental soil science - The ... History of glaciology - history of the study of glaciers, or more generally ice and natural phenomena that involve ice. History ... magma and associated phenomena Geography - The science that studies the terrestrial surface, the societies that inhabit it and ...
Krešimir Krnjević
Kresimir Krnjevic (in French) Krnjević, Krešimir (1953). "The effect of biochemical changes upon certain biophysical phenomena ...
Pulsatile secretion
... is a biochemical phenomenon observed in a wide variety of cell and tissue types, in which chemical products ... Hellman B (2009). "Pulsatility of insulin release--a clinically important phenomenon". Upsala Journal of Medical Sciences. 114 ...
Artificial chemistry
... and other biochemical phenomena. The field does not use actual chemicals, and should not be confused with either synthetic ... Artificial chemistry is a field within computer science wherein chemical reactions-often biochemical ones-are computer- ...
Haldan Keffer Hartline
... and Ragner Granit in 1967 for discoveries concerning the primary biochemical and physiological phenomena ...
George Wald
Haldan Keffer Hartline and Ragner Granit in 1967 for discoveries concerning the primary biochemical and physiological phenomena ...
History of evolutionary thought
... brought biochemical phenomena into the realm of the synthetic theory of evolution. In the early 1960s, biochemists Linus ... Pierre Teilhard de Chardin's metaphysical Omega Point theory, found in his book The Phenomenon of Man (1955), describes the ... "Teilhard de Chardin: The Phenomenon of Man: a Compendium". Retrieved 2015-06-15. Castillo, Mauricio (March 2012). "The Omega ... Teilhard de Chardin, Pierre (1959) [Originally published 1955; Paris: Éditions du Seuil]. Le phénomène humain [The Phenomenon ...
Raynaud syndrome
December 1999). "Losartan therapy for Raynaud's phenomenon and scleroderma: clinical and biochemical findings in a fifteen-week ... Raynaud's phenomenon is the initial symptom that presents for 70% of patients with scleroderma, a skin and joint disease.[ ... Raynaud's phenomenon, or secondary Raynaud's, occurs secondary to a wide variety of other conditions. Secondary Raynaud's has a ... The 2009 article studied 19 patients ranging in age from 15 to 72 years with severe Raynaud's phenomenon of which 16 patients ( ...
Permissiveness (biology)
In endocrinology, permissiveness is a biochemical phenomenon in which the presence of one hormone is required in order for ...
List of MeSH codes
... biological phenomena, cell phenomena, and immunity G05 - genetic processes G06 - biochemical phenomena, metabolism, and ... chemical and pharmacologic phenomena G13 - genetic phenomena G14 - genetic structures H - Physical Sciences H01 - natural ... psychological phenomena and processes F03 - mental disorders F04 - behavioral disciplines and activities G - Biological ... sciences I - Anthropology, Education, Sociology and Social Phenomena I01 - social sciences I02 - education I03 - human ...
Lipid bilayer
This phase separation plays a critical role in biochemical phenomena because membrane components such as proteins can partition ... It is believed that this phenomenon results from the energetically active edges formed during electroporation, which can act as ... The addition of polyethylene glycol (PEG) causes fusion without significant aggregation or biochemical disruption. This ... and biochemical interactions. While lipid tails primarily modulate bilayer phase behavior, it is the headgroup that determines ...
Edwin N. Lightfoot
... "for his innovative research and leadership in transport phenomena focusing on biochemical and biomedical engineering with ... Transport Phenomena Transport Phenomena in Living Systems: Biomedical Aspects of Momentum and Mass Transport Edward N. ... There he co-authored Transport Phenomena with his colleagues R. Byron Bird and Warren E. Stewart. This first edition of this ... qbio 2016 "Renowned biochemical engineer Edwin N. Lightfoot passes away - College of Engineering - University of Wisconsin- ...
Tobacco BY-2 cells
... makes it very difficult to investigate and understand some general biochemical phenomena of living plant cells. The transport ...
Post-mortem (disambiguation)
Post-mortem may also refer to: Post-mortem chemistry, a branch of chemistry for studying of chemical and biochemical phenomena ...
Lipid bilayer phase behavior
This phase separation plays a critical role in biochemical phenomena because membrane components such as proteins can partition ... This phenomenon is analogous to the fact that paraffin wax, which is composed of long alkanes, is solid at room temperature, ... Such mixtures often exhibit properties intermediate to their components, but are also capable of a phenomenon not seen in ... Journal of Biochemical and Biophysical Methods. 20 (4): 353-356. doi:10.1016/0165-022x(90)90097-v. PMID 2365951. (Membrane ...
Biophysical chemistry
An International Journal devoted to the Physics and Chemistry of Biological Phenomena (Elsevier), Journal of Biochemical and ... The most common feature of the research in this subject is to seek explanation of the various phenomena in biological systems ... Biochemical and Biophysical Research Communications (Academic Press), Biochimica et Biophysica Acta (Elsevier Science), ...
Quantum biology
... to macroscopic phenomena (e.g. biochemicals). Aside from hydrogen tunneling, studies also show that electron transfer between ... Quantum biology is concerned with the influence of non-trivial quantum phenomena, which can be explained by reducing the ... Another theory (based on quantum phenomena) suggests that the olfactory receptors detect the vibration of the molecules that ... Other examples of quantum phenomena in biological systems include the conversion of chemical energy into motion and brownian ...
Biochemical switches in the cell cycle
This phenomenon is enhanced when considering phosphorylation. Phosphorylation of cyclin B promotes translocation to the nucleus ... A series of biochemical switches control transitions between and within the various phases of the cell cycle. The cell cycle is ... In a sequence of biochemical events, feedback would refer to a downstream element in the sequence (B in the adjacent image) ... In the mechanism of biochemical switches, they work together to create a flexible system. For example, according to Pfeuty & ...
Hibernation
Physiological and Biochemical Zoology. 76 (2): 165-179. doi:10.1086/367950. PMID 12794670. S2CID 14675451. Hellgren, Eric C. ( ... further research has been unable to reproduce this phenomenon. Despite the inability to induce torpor, there are substances in ...
Metabolism
The mass of biochemical knowledge grew rapidly throughout the early 20th century. One of the most prolific of these modern ... Cellular phenomena Oncometabolism Reactome - Database of biological pathways KEGG - Collection of bioinformatics databases ... These biochemicals can be joined to make polymers such as DNA and proteins, essential macromolecules of life. Proteins are made ... Modern biochemical research has been greatly aided by the development of new techniques such as chromatography, X-ray ...
Conium maculatum
The alkaloid content found in C. maculatum also affects the thermoregulatory centre by a phenomenon called peripheral ... Biochemical Journal. 64 (2): 259-266. doi:10.1042/bj0640259. ISSN 0264-6021. PMC 1199726. PMID 13363836. Roberts, Margaret F. ( ...
Listener fatigue
Common groups at risk of becoming victim to this phenomenon include avid listeners of music and others who listen or work with ... With regards to listening fatigue, the relevant mechanical and biochemical mechanisms primarily deal with inner ear and cochlea ... Listener fatigue (also known as listening fatigue or ear fatigue) is a phenomenon that occurs after prolonged exposure to an ...
Glass electrode
The existence of these phenomena means that glass electrodes must always be calibrated before use; a common method of ... Kerridge, Phyllis Margaret Tookey (1925). "The Use of the Glass Electrode in Biochemistry". Biochemical Journal. 19 (4): 611- ...
Philosophy of science
For example, can all chemical phenomena be explained by quantum mechanics or is it not possible to reduce chemistry to physics ... Other key ideas such as the reduction of all life processes to biochemical reactions as well as the incorporation of psychology ... It says that a successful scientific explanation must deduce the occurrence of the phenomena in question from a scientific law ... Others have argued that the key to a good explanation is unifying disparate phenomena or providing a causal mechanism. Although ...
List of Puerto Rican scientists and inventors
Bras has specialized in the interpretation of natural phenomena as random functions. He has been recognized for his use of ... Biochemical and Biophysical Research Communications. 147 (2): 846-53. doi:10.1016/0006-291X(87)91007-2. PMID 3115266. Genetic ...
Spontaneous remission
But both mechanisms need appropriate biochemical triggers and cannot initiate on their own. Indeed, in many cancer cells ... from cancer are rare phenomena, and that some forms of cancer are more prone to unexpected courses (melanoma, neuroblastoma, ...
Sigma-1 receptor
It has been implicated in several phenomena, including cardiovascular function, schizophrenia, clinical depression, the effects ... Biochemical and Biophysical Research Communications. 229 (2): 553-558. doi:10.1006/bbrc.1996.1842. PMID 8954936. Prasad PD, Li ...
Swell shark
The biochemical origin of 6-bromo-tryptophan in these species is not known. There are no fishery operations that target swell ... A Phylogenetically Widespread and Phenotypically Variable Phenomenon". PLOS ONE. 9 (1): e83259. Bibcode:2014PLoSO...983259S. ...
Huda Akil
Watson, Stanley J.; Akil, Huda; Walker, J. Michael (1980). "Anatomical and biochemical studies of the opioid peptides and ... and the idea that phantom pain was not a purely physical phenomenon, but had a psychological role as well. Another member of ... A combination of behavioral, pharmacological, and biochemical research led Akil and colleagues of the Barchas Laboratory at ... to continue to research this phenomenon, which they later referred to as "stimulation produced analgesia" (SPA). Working on ...
Anger management
Wright, Day, & Howells referred to this phenomenon as the "hijacking of the cognitive system by the emotional system". Second, ... Drug addiction, alcoholism, a mental disability, biochemical changes and PTSD can all lead to a person committing an aggressive ...
Islam in Taiwan
These phenomena gives a boost to the Islamic activities in Taiwan. Speaking at Taipei Grand Mosque in December 2001 during Eid ... Excellence Food Biochemical, Taiwan Smile Food, Jiou Long Jai Foodstuff, Ruhn Chan International and Tsan Yu Yen Foods. Some ...
Bioluminescence
He studied the phenomenon for many years. His research aimed to demonstrate that luciferin, and the enzymes that act on it to ... While popular at first, Seliger's theory has been challenged, particularly on the biochemical and genetic evidence that Rees ... The phenomenon is widely distributed among animal groups, especially in marine environments. On land it occurs in fungi, ... This hypothesis has since been disproven, but it did lead to considerable interest in the origins of the phenomenon. Today, the ...
Physiologically based pharmacokinetic modelling
PBPK models can first be used to abstract and eventually reconcile disparate data (from physicochemical or biochemical ... and chemical descriptions of the phenomena involved in the complex ADME processes. A large degree of residual simplification ... Biochemical Pharmacology. 22 (19): 2405-2417. doi:10.1016/0006-2952(73)90342-0. PMID 4200888. Gerlowski, L.E.; Jain, R.K. (1983 ... Biochemical System Simulator Ecolego Free simulation software: GNU MCSIM GNU Octave Matlab PottersWheel ModelMaker PhysioLab R ...
Laboratory rat
Long JA, Evans HM (1922). The oestrous cycle in the rat and its associated phenomena. University of California Press. Suckow MA ... Biochemical and Biophysical Research Communications. 73 (4): 869-75. doi:10.1016/0006-291X(76)90202-3. PMID 15625855. Sukov W, ... Biochemical and Biophysical Research Communications. 225 (1): 75-83. doi:10.1006/bbrc.1996.1133. PMID 8769097. Kava R, ...
Enzyme inhibitor
Leatherbarrow RJ (December 1990). "Using linear and non-linear regression to fit biochemical data". Trends in Biochemical ... Enzyme inactivation is generally explained as a chemical process involving several phenomena like aggregation, dissociation ... Maggi M, Filippi S, Ledda F, Magini A, Forti G (August 2000). "Erectile dysfunction: from biochemical pharmacology to advances ... Hartley RW (November 1989). "Barnase and barstar: two small proteins to fold and fit together". Trends in Biochemical Sciences ...
Belousov-Zhabotinsky reaction
The discovery of the phenomenon is credited to Boris Belousov. In 1951, while trying to find the non-organic analog to the ... Dueñas-Díez M, Pérez-Mercader J (2019). "How Chemistry Computes: Language Recognition by Non-Biochemical Chemical Automata. ... In this sense, they provide an interesting chemical model of nonequilibrium biological phenomena; as such, mathematical models ... and simulations of the BZ reactions themselves are of theoretical interest, showing phenomenon as noise-induced order. An ...
Peter Medawar
Medawar presented a talk on viviparity in animals (the phenomenon by which some animals give live birth) at a meeting on ... Rose, S. (1988). "Reflections on reductionism". Trends in Biochemical Sciences. 13 (5): 160-162. doi:10.1016/0968-0004(88)90138 ... Medawar, Peter (1996). "The Phenomenon of Man". The Strange Case of the Spotted Mice: And other classic essays on science. ... the phenomenon of unresponsiveness of the immune system to certain molecules), which was theoretically predicted by Sir Frank ...
ENDOG
It is a mode of cell death defined by characteristic morphological, biochemical and molecular changes. It was first described ... Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue ... Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required ... Biochemical and Biophysical Research Communications. 451 (4): 644-9. doi:10.1016/j.bbrc.2014.08.047. PMID 25139236. Danial NN, ...
HSPA8
Soss SE, Rose KL, Hill S, Jouan S, Chazin WJ (2015). "Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 ... Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue ... It is a mode of cell death defined by characteristic morphological, biochemical and molecular changes. It was first described ... Biochemical and Biophysical Research Communications. 213 (1): 1-6. doi:10.1006/bbrc.1995.2090. PMID 7639722. Inoue A, Torigoe T ...
Free will
23: But the fact is overlooked that the individual, the person, is not will as thing-in-itself, but is phenomenon of the will, ... and desires are fixed by our genetic endowment and our biochemical makeup, the latter of which is affected by both genes and ... On that basis "…free will cannot be squeezed into time frames of 150-350 ms; free will is a longer term phenomenon" and free ... This phenomenon corresponds with an impairment in the premotor mechanism manifested temporally by the appearance of the ...
Brain
In 1971 Tim Bliss and Terje Lømo published a paper on a phenomenon now called long-term potentiation: the paper showed clear ... The electrical properties of neurons are controlled by a wide variety of biochemical and metabolic processes, most notably the ... Cooper, JR; Bloom, FE; Roth, RH (2003). The Biochemical Basis of Neuropharmacology. Oxford University Press US. ISBN 978-0-19- ...
Kenneth B. Storey
Storey has a world-wide reputation for his research on biochemical adaptation - the molecular mechanisms that allow animals to ... His studies have identified molecular mechanisms that underlie metabolic arrest across phylogeny and that support phenomena ...
Industrial enzymes
Due to variations in the distribution of dissolved oxygen, as well as temperature, pH, and nutrients, the transport phenomena ... Typically, intracellular enzymes require cell lysis and separation of complex biochemical mixtures. Extracellular enzymes are ... Enzyme adsorption onto carriers functions based on chemical and physical phenomena such as van der Waals forces, ionic ...
Pheochromocytoma
When interpreting a biochemical analysis for pheochromocytoma, the provider must pay close attention to the (1) conditions of ... However, the patient should be warned about the potential side-effect known as "the first-dose phenomenon." When patients are ... March 2002). "Biochemical diagnosis of pheochromocytoma: which test is best?". JAMA. 287 (11): 1427-34. doi:10.1001/jama.287.11 ... There are (3) major, well-recognized biochemical phenotypes that can be used by health care providers to direct patient care. ...
Aequorin
It lacks phenomena of intracellular compartmentalization or sequestration as is often seen for Voltage-sensitive dyes, and does ... Shimomura O (1995). "Luminescence of aequorin is triggered by the binding of two calcium ions". Biochemical and Biophysical ...
Biomolecular condensate
Thomson JA, Schurtenberger P, Thurston GM, Benedek GB (October 1987). "Binary liquid phase separation and critical phenomena in ... Trends in Biochemical Sciences. 43 (2): 81-94. doi:10.1016/j.tibs.2017.11.005. PMID 29258725. Boeynaems S, Alberti S, Fawzi NL ... "Hence the study of life may be best begun by the study of those physico-chemical phenomena which result from the contact of two ... Biochemical Society Transactions. 30 (Pt 6): 963-9. doi:10.1042/bst0300963. PMID 12440955. An S, Kumar R, Sheets ED, Benkovic ...
Heme
In biochemical terms, heme is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a ... This phenomenon, which states that hemoglobin's oxygen binding affinity is inversely proportional to both acidity and ... Thom, C. S. (2013). "Hemoglobin Variants: Biochemical Properties and Clinical Correlates". Cold Spring Harbor Perspectives in ...
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Biochemistry Quotes - 49 quotes on Biochemistry Science Quotes - Dictionary of Science Quotations and Scientist Quotes
... with the dynamic side of biochemical phenomena. ... If we sink to the biochemical level, then the human being has ... Interview in Vital Holistic Phenomena and Properties of Living, The World & I (1986), 1, No. 5-6, 265. ... For the further analysis of these phenomena which are in flux and flow, the investigator must associate himself with those who ... Phenomenon (329) , Plant (313) , Problem (708) , Process (430) , Scalpel (4) , Solution (275) , Soon (186) , Study (679) , ...
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3. quantitative Knowledge of biochemical phenomena.. 4. Understanding of bioinformatics (methods and practices) ... Application of biochemical knowledge for the comprehension of function of organism and environment;. - Ability to understand ... Understanding the modern approaches to biochemical research.. LEARNING OUTCOMES. • Cognitive skills. - Basic elements of ... Nucleotides and Nucleic Acids: Biochemical functions of nucleotides. Structure of nucleic acids.. - Enzymes: Catalysis. ...
Comprehensive Insight into the Elderflowers and Elderberries (Sambucus nigra L.) Mono and Sesquiterpenic Metabolites: Factors...
... and understanding these phenomena is the first step for S. nigra berries and flowers valuation. This chapter will cover ... Complex and dynamic external and internal plant-related phenomena deeply affect terpenes profile, as metabolism, abiotic and ... is a crucial phenomenon that affects different physiological and biochemical processes, which are determinant to the ... Biochemical Systematics and Ecology. 2015;. 61. :44-53. *40. Ağalar H, Demirci B, Demirci F, Kırımer N. The volatile compounds ...
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EF Hand Motifs | Profiles RNS
DeCS 2007 - New terms
G06 - Biochemical Phenomena, Metabolism, and Nutrition. Autotrophic Processes. Processos Autotróficos. Procesos Autotróficos. ... G04 - Biological Phenomena, Cell Phenomena, and Immunity. Allostasis. Alostase. Alostasis. Cell Nucleus Shape. Forma do Núcleo ... Nutrition Phenomena. Fenômenos Nutricionais. Fenómenos de la Nutrición. Nutrition Processes. Processos Nutricionais. Procesos ... Digestive System Phenomena. Fenômenos do Sistema Digestório. Fenómenos del Sistema Digestivo. Digestive System Processes. ...
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Pseudoaneurysmus: US-Guided Compression Therapy with Color and Power Doppler
Hydrogen peroxide in regulation of plant metabolism: Signalling and its effect under abiotic stress<...
In plants, hydrogen peroxide (H2O2) acts as a signalling molecule that facilitates various biochemical and physiological ... N2 - In plants, hydrogen peroxide (H2O2) acts as a signalling molecule that facilitates various biochemical and physiological ... AB - In plants, hydrogen peroxide (H2O2) acts as a signalling molecule that facilitates various biochemical and physiological ... abstract = "In plants, hydrogen peroxide (H2O2) acts as a signalling molecule that facilitates various biochemical and ...
Diamond Publications - Search Results
Neurons caught rapidly switching gears | ערוץ 7
Dataism threat: Highly intelligent algorithm knows us better than we do ourselves
Life scientists assess that emotions are bio - chemical algorithms and not spiritual phenomenon. Algorithms are defined as a ... The operation of free will is not behind desire, which process is created by bio-chemical changes in brain. The process may be ... Individuals will turn into bio-chemical and electronic algorithms without clear borders, and without individual hubs. The ...
English
While they share most chemical and physical properties, enantiomers can have adverse effects in (bio)chemical phenomena. For ... bio)chemical processes," says Malte Oppermann. "This offers a new way for investigating challenging dynamic phenomena - for ... Consequently, identification and control of chirality is often key to designing (bio)chemical compounds, e.g. in the food, ... bio)chemical activity. This makes it possible to capture the chirality of photoexcited molecules and to resolve the ...
The Angiogenesis Foundation's Declaration of War on Cancer and Other Non-Communicable Diseases Using Diet|The Angiogenesis...
Metabolism1
- Complex and dynamic external and internal plant-related phenomena deeply affect terpenes profile, as metabolism, abiotic and biotic stresses, and understanding these phenomena is the first step for S. nigra berries and flowers' valuation. (intechopen.com)
Chemical Phenomena1
- While they share most chemical and physical properties, enantiomers can have adverse effects in (bio)chemical phenomena. (chemeurope.com)
Molecular Biology1
- The Eagen Lab combines concepts and approaches from structural biology and biochemistry with methods and analytical tools from molecular biology and genomics to determine the structural and biochemical basis of chromatin folding and chromosome condensation. (nih.gov)
Processes3
- These species permit detailed physiological, pharmacological, and biochemical investigations, but are limited by the current lack of available techniques to allow precise and systematic alterations in their genetic composition and, thus, to precisely define the contributions of specific genes and/or their encoded proteins in cardiovascular disease processes. (nih.gov)
- In plants, hydrogen peroxide (H 2 O 2 ) acts as a signalling molecule that facilitates various biochemical and physiological processes. (uaeu.ac.ae)
- abstract = "In plants, hydrogen peroxide (H2O2) acts as a signalling molecule that facilitates various biochemical and physiological processes. (uaeu.ac.ae)
Quantitative2
- 3. quantitative Knowledge of biochemical phenomena. (uninsubria.eu)
- Advances in numerous areas of the biological and medical sciences will continue to require a quantitative understanding of the complex network of biochemical interactions underlying biological phenomena. (nih.gov)
Organisms1
- For the further analysis of these phenomena which are in flux and flow, the investigator must associate himself with those who have labored in fields where molecules and atoms, rather than multicellular tissues or even unicellular organisms, are the units of study. (todayinsci.com)
Complex1
- Alex thinks that complex phenomena - including of course consciousness, free will, etc. - are not just compatible with, but determined by and reducible to, the fundamental level of physics. (blogspot.com)
Research2
- The plan calls for research into the biochemical pathways and other physiological phenomenon of pregnancy and preterm birth, ultimately to find ways to prevent preterm birth. (nih.gov)
- Understanding the modern approaches to biochemical research. (uninsubria.eu)
Term1
- Some parts of the brain have already been shown to be less rigidly determined than thought - a phenomenon known as plasticity - but this occurs on slower time-scales, reflecting longer-term biochemical changes in the brain's synapses, the connections between neurons. (israelnationalnews.com)
Tools1
- Conceptual and Experimental Tools to Understand Spatial Effects and Transport Phenomena in Nonlinear Biochemical Networks Illustrated with Patchy Switching. (bvsalud.org)
Biological Phenomena1
- Advances in numerous areas of the biological and medical sciences will continue to require a quantitative understanding of the complex network of biochemical interactions underlying biological phenomena. (nih.gov)
Concepts1
- The Eagen Lab combines concepts and approaches from structural biology and biochemistry with methods and analytical tools from molecular biology and genomics to determine the structural and biochemical basis of chromatin folding and chromosome condensation. (nih.gov)