Bioartificial Organs
Liver, Artificial
Artificial Organs
Kidneys, Artificial
Liver Failure, Acute
Bioreactors
Liver Failure
Hepatocytes
Tissue Engineering
Extracorporeal Circulation
Pancreas, Artificial
Swine, Miniature
Albumins
Ammonia
Swine
Excitability and contractility of skeletal muscle engineered from primary cultures and cell lines. (1/58)
The purpose of this study was to compare the excitability and contractility of three-dimensional skeletal muscle constructs, termed myooids, engineered from C2C12 myoblast and 10T1/2 fibroblast cell lines, primary muscle cultures from adult C3H mice, and neonatal and adult Sprague-Dawley rats. Myooids were 12 mm long, with diameters of 0.1-1 mm, were excitable by transverse electrical stimulation, and contracted to produce force. After approximately 30 days in culture, myooid cross-sectional area, rheobase, chronaxie, resting baseline force, twitch force, time to peak tension, one-half relaxation time, and peak isometric force were measured. Specific force was calculated by dividing peak isometric force by cross-sectional area. The specific force generated by the myooids was 2-8% of that generated by skeletal muscles of control adult rodents. Myooids engineered from C2C12-10T1/2 cells exhibited greater rheobase, time to peak tension, and one-half relaxation time than myooids engineered from adult rodent cultures, and myooids from C2C12-10T1/2 and neonatal rat cells had greater resting baseline forces than myooids from adult rodent cultures. (+info)Injectable gels for tissue engineering. (2/58)
Recently, tissue engineering approaches using injectable, in situ gel forming systems have been reported. In this review, the gelation processes and several injectable systems that exhibit in situ gel formation at physiological conditions are discussed. Applications of selected injectable systems (alginate, chitosan, hyaluronan, polyethylene oxide/polypropylene oxide) in tissue engineering are also described. Injectable polymer formulation can gel in vivo in response to temperature change (thermal gelation), pH change, ionic cross-linking, or solvent exchange. Kinetics of gelation is directly affected by its mechanism. Injectable formulations offer specific advantages over preformed scaffolds such as: possibility of a minimally invasive implantation, an ability to fill a desired shape, and easy incorporation of various therapeutic agents. Several factors need to be considered before an injectable gel can be selected as a candidate for tissue engineering applications. Apart from tissue-specific cell-matrix interactions, the following gel properties need to be considered: gelation kinetics, matrix resorption rate, possible toxicity of degradation products and their elimination routes, and finally possible interference of the gel matrix with histogenesis. (+info)Tissue engineering strategies for adipose tissue repair. (3/58)
Tissue engineering is a relatively young field that combines engineering, clinical science, and life sciences to, in part, repair or regrow tissues. Adipose tissue has recently become a focus area for tissue engineering, encouraged by the large number of reconstructive, cosmetic, and correctional indications that could be addressed with clinically translatable adipose tissue engineering strategies. This review discusses the three aspects of an adipose construct, namely cell types, scaffold, and microenvironment, and presents current tissue engineering strategies under pursuit. (+info)Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart. (4/58)
Achieving the lofty goal of developing a tissue engineered heart will likely rely on progress in engineering the various components: blood vessels, heart valves, and cardiac muscle. Advances in tissue engineered vascular grafts have shown the most progress to date. Research in tissue-engineered vascular grafts has focused on improving scaffold design, including mechanical properties and bioactivity; genetically engineering cells to improve graft performance; and optimizing tissue formation through in vitro mechanical conditioning. Some of these same approaches have been used in developing tissue engineering heart valves and cardiac muscle as well. Continued advances in scaffold technology and a greater understanding of vascular cell biology along with collaboration among engineers, scientists, and physicians will lead to further progress in the field of cardiovascular tissue engineering and ultimately the development of a tissue-engineered heart. (+info)Tissue engineering in plastic reconstructive surgery. (5/58)
Tissue engineering (TE) is a new interdisciplinary field of applied research combining engineering and biosciences together with clinical application, mainly in surgical specialities, to develop living substitutes for tissues and organs. Tissue engineering approaches can be categorized into substitutive approaches, where the aim is the ex vivo construction of a living tissue or organ similar to a transplant, vs. histioconductive or histioinductive concepts in vivo. The main successful approaches in developing tissue substitutes to date have been progresses in the understanding of cell-cell interactions, the selection of appropriate matrices (cell-matrix interaction) and chemical signalling (cytokines, growth factors) for stimulation of cell proliferation and migration within a tissue-engineered construct. So far virtually all mammalian cells can be cultured under specific culture conditions and in tissue specific matrices. Future progress in cell biology may permit the use of pluripotent stem cells for TE. The blueprint for tissue differentiation is the genome: for this it is reasonable to combine tissue engineering with gene therapy. The key to the progress of tissue engineering is an understanding between basic scientists, biochemical engineers, clinicians, and industry. (+info)Engineering of vascular ingrowth matrices: are protein domains an alternative to peptides? (6/58)
Anastomotic intimal hyperplasia and surface thrombogenicity are the main reasons for the high failure rate of prosthetic small-diameter vascular grafts. While anastomotic intimal hyperplasia is a multifactorial event, ongoing surface thrombogenicity is primarily caused by the lack of an endothelium, even after years of clinical implantation. After decades of poorly performing synthetic artery-grafts, tissue engineering has emerged as a promising approach to generate biologically functional bio-synthetic hybrid grafts mimicking native arteries regarding the presence of an endothelial lining on the blood surface. "In vitro endothelialization" represented the first generation of such tissue-engineered vascular grafts, utilising cell culture techniques for the creation of a confluent autologous endothelium on ePTFE grafts. The clinical long-term results with this method in almost 200 patients are highly encouraging, showing patencies equal to vein grafts. Since "in vitro endothelialization" requires cell culture facilities, it will always be confined to large centres. Therefore, research of the 1990s turned to the development of spontaneously endothelializing implants, to make tissue-engineered grafts amenable to the entire vascular-surgical community. Apart from scaffold designs allowing transmural ingrowth, biological signalling through a facilitating ingrowth matrix holds a key to spontaneous endothelialization. In biological signalling, the increasingly deeper understanding of bio-active molecules and the discovery of domains and peptide sequences during the 1980s created the expectation in the 1990s that peptide signalling may be all that is needed. This present review highlights the possible problems associated with such a reductionist approach. Using the fibronectin molecule, we demonstrated that domains may be more suitable modules in tissue engineering than peptide sequences. (+info)Peripheral nerve injury: a review and approach to tissue engineered constructs. (7/58)
Eleven thousand Americans each year are affected by paralysis, a devastating injury that possesses associated annual costs of $7 billion (American Paralysis Association, 1997). Currently, there is no effective treatment for damage to the central nervous system (CNS), and acute spinal cord injury has been extraordinarily resistant to treatment. Compared to spinal cord injury, damage to peripheral nerves is considerably more common. In 1995, there were in excess of 50,000 peripheral nerve repair procedures performed. (National Center for Health Statistics based on Classification of Diseases, 9th Revision, Clinical Modification for the following categories: ICD-9 CM Code: 04.3, 04.5, 04.6, 04.7). These data, however, probably underestimate the number of nerve injuries appreciated, as not all surgical or traumatic lesions can be repaired. Further, intraabodominal procedures may add to the number of neurologic injuries by damage to the autonomic system through tumor resection. For example, studies assessing the outcome of impotency following radical prostatectomy demonstrated 212 of 503 previously potent men (42%) suffered impotency when partial or complete resection of one or both cavernosal nerve(s). This impotency rate decreased to 24% when the nerves were left intact (Quinlan et al., J. Urol. 1991;145:380-383; J. Urol. 1991;145:998-1002). (+info)Self-assembly and mineralization of peptide-amphiphile nanofibers. (8/58)
We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone. (+info)Causes:
1. Viral hepatitis (hepatitis A, B, or C)
2. Overdose of medications or supplements
3. Toxic substances (e.g., alcohol, drugs, or chemicals)
4. Sepsis or other infections that spread to the liver
5. Certain autoimmune disorders (e.g., hemochromatosis, Wilson's disease)
6. Cancer that has metastasized to the liver
7. Blood vessel blockage or clotting in the liver
8. Lack of blood flow to the liver
Symptoms:
1. Jaundice (yellowing of skin and eyes)
2. Nausea and vomiting
3. Abdominal swelling and discomfort
4. Fatigue, weakness, and loss of appetite
5. Confusion or altered mental state
6. Seizures or coma
7. Pale or clay-colored stools
8. Dark urine
Diagnosis:
1. Physical examination and medical history
2. Laboratory tests (e.g., liver function tests, blood tests, imaging studies)
3. Biopsy of the liver tissue (to rule out other liver diseases)
Treatment:
1. Supportive care (fluids, nutrition, and medication to manage symptoms)
2. Addressing underlying causes (e.g., stopping alcohol or drug use, treating infections)
3. Transjugular intrahepatic portosystemic shunt (TIPS), a procedure that creates a new pathway for blood to flow through the liver
4. Liver transplantation (in severe cases where other treatments have failed)
Prognosis:
The prognosis for acute liver failure depends on the underlying cause of the condition and the severity of the liver damage. In general, the earlier the diagnosis and treatment, the better the outcome. However, acute liver failure can be a life-threatening condition, and the mortality rate is high, especially in cases where there is severe liver damage or no available donor liver for transplantation.
There are several causes of liver failure, including:
1. Alcohol-related liver disease: Prolonged and excessive alcohol consumption can damage liver cells, leading to inflammation, scarring, and eventually liver failure.
2. Viral hepatitis: Hepatitis A, B, and C are viral infections that can cause inflammation and damage to the liver, leading to liver failure.
3. Non-alcoholic fatty liver disease (NAFLD): A condition where there is an accumulation of fat in the liver, leading to inflammation and scarring.
4. Drug-induced liver injury: Certain medications can cause liver damage and failure, especially when taken in high doses or for extended periods.
5. Genetic disorders: Certain inherited conditions, such as hemochromatosis and Wilson's disease, can cause liver damage and failure.
6. Acute liver failure: This is a sudden and severe loss of liver function, often caused by medication overdose or other toxins.
7. Chronic liver failure: A gradual decline in liver function over time, often caused by cirrhosis or NAFLD.
Symptoms of liver failure can include:
1. Jaundice (yellowing of the skin and eyes)
2. Fatigue
3. Loss of appetite
4. Nausea and vomiting
5. Abdominal pain
6. Confusion and altered mental state
7. Easy bruising and bleeding
Diagnosis of liver failure is typically made through a combination of physical examination, medical history, and laboratory tests, such as blood tests to check for liver enzymes and bilirubin levels. Imaging tests, such as ultrasound and CT scans, may also be used to evaluate the liver.
Treatment of liver failure depends on the underlying cause and severity of the condition. In some cases, a liver transplant may be necessary. Other treatments may include medications to manage symptoms, such as nausea and pain, and supportive care to maintain nutrition and hydration. In severe cases, hospitalization may be required to monitor and treat complications.
Prevention of liver failure is important, and this can be achieved by:
1. Avoiding alcohol or drinking in moderation
2. Maintaining a healthy weight and diet
3. Managing underlying medical conditions, such as diabetes and high blood pressure
4. Avoiding exposure to toxins, such as certain medications and environmental chemicals
5. Getting vaccinated against hepatitis A and B
6. Practicing safe sex to prevent the spread of hepatitis B and C.
Sangeeta N. Bhatia
Tissue engineering
Cell encapsulation
Bioartificial heart
Organ printing
Artificial kidney
Regeneration in humans
Biomedical engineering
List of MeSH codes (E07)
Liver support system
Korkut Uygun
Organ-on-a-chip
Artificial organ
Organ culture
Artificial cell
Decellularization
Doris Taylor
Liver transplantation
Thorsten Walles
Automated insulin delivery system
Cardiomyoplasty
Neurotrophic factors
Nerve guidance conduit
Paolo Macchiarini
Artificial cartilage
2015 in science
Bioartificial Organ Manufacturing Market Adve | Articles | AgFuse
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September | 2018 | A-Inhibitor
Artificial Organs5
- The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. (sagepub.com)
- Th e International Journal of Artificial Organs (IJAO) is the Official Journal of the European Society for Artificial Organs (ESAO). (sagepub.com)
- Artificial organs that are composites of biomaterials and cells. (nih.gov)
- One of the goals of tissue engineering is to create artificial organs for patients that need organ transplants. (wikiversity.org)
- ESAO is the European Society for Artificial Organs. (bioart-fp7.eu)
Biomaterials1
- Reporting in the March issue of Biomaterials , Emmanuel Opara at Wake Forest University, North Carolina, and colleagues, describe how using tissue from rats, they made a bioartificial ovary by placing two hormone-producing ovary cells in an algal capsule to simulate the natural follicular environment, and then stimulated it using pituitary gland hormones. (medicalnewstoday.com)
LIVER8
- The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin. (nih.gov)
- Bioartificial organs, which utilize both synthetic and biological components, are also a focus area in research, such as with hepatic assist devices that utilize liver cells within an artificial bioreactor construct[2]. (wikiversity.org)
- We are working together to develop new organ-on-a-chip systems for the endothelium, intestine, lung, liver and nervous system. (hdmt.technology)
- As a result, alternate liver support technologies like bioartificial liver (BAL) devices analogus to kidney dialysis units, cell and tissue-engineering based therapies acts as a clinical bridge by performing some functions and providing sufficient time for injured liver to recover. (atlasofscience.org)
- Functional hepatocyte clusters on bioactive blend silk matrices towards generating bioartificial liver constructs. (atlasofscience.org)
- Liver organoids can be used for drug testing, as a model of liver disease pathogenesis, and as a bioartificial liver prototype material to develop promising alternative therapies for liver failure. (ui.ac.id)
- As a future direction, these organoids can be used to develop a bioartificial liver. (ui.ac.id)
- The liver is an important organ that performs many functions, such as protein synthesis, drug biotransformation, and detoxification (Li et al. (ui.ac.id)
Tissues6
- The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs. (sagepub.com)
- This section covers artificial and bioartificial tissues and organs to replace/correct sensory deficits (e.g., ear, eye etc.), as well as nerve and central nervous system stimulation. (sagepub.com)
- This section focuses on the development, characterization and use of bioengineered tissues and organs, and on techniques to investigate and promote tissue or organ self-regeneration including cell therapies. (sagepub.com)
- With high-tech 3D printing, there is the possibility of creating not only drugs and prosthesis but also human organs and tissues. (neoteryx.com)
- These organs and tissues will bring very exciting solutions to many diseases including chronic ones. (neoteryx.com)
- Bioprinting advances have revolutionised drug discovery and are set to disrupt biomedical research and medical application through the development of reproducible, fine-tuned functional 3D tissues and, eventual y, whole organs. (who.int)
Kidney5
- For instance, Vanderbilt University has an undergoing project to develop a bioartificial kidney. (neoteryx.com)
- This is, to quote the homepage " a national research project with a goal to create a small, surgically implanted, and free-standing bioartificial kidney to treat end stage renal disease (ESRD). (unfilteredakc.com)
- One line of research focuses on improving the ability of artificial and bioartificial kidney devices to remove uremic toxins from blood. (bioart-fp7.eu)
- The BIOART researchers are proud to announce that they have developed a key component needed to create a bioartificial kidney. (bioart-fp7.eu)
- A key component needed in a bioartificial kidney is a " living membrane " and this is just what Prof. Stamatialis, Prof Masereeuw and their colleagues managed to achieve. (bioart-fp7.eu)
Regenerative1
- It reduces the gap processes, there are simultaneously, rapidly growing alternative between ex vivo cell cultures and in vivo cel ular tissue models, and technologies/research areas that aim to target organ shortages and there has been a significant increase in research and development for patient-specific therapies within the field of regenerative medicine. (who.int)
Prostheses2
- This section deals with left ventricular assist devices, trans-apical by-pass, extracorporeal heart assist devices, total artificial heart, valve implants, vascular prostheses, and organ perfusion equipment and techniques. (sagepub.com)
- This section deals with the development and clinical use of mechanical prostheses and robotic systems, as well with new and emerging medical technologies for assistance of patients with organ or tissue failure, in need of rehabilitation and disease prevention. (sagepub.com)
Donor organs2
- Now scientists are exploring several methods to trick the body's immune system into accepting artificial and harvested donor organs. (popsci.com)
- These problems together with the scarcity of donor organs and the complexity of transplants mandates a renewed emphasis on the investigation of novel methods within the field of tissue engineering for the development of a bio-artificial, cell-based hormone replacement therapy that may minimize the need of IS. (nih.gov)
Tissue3
- This section covers genomic, proteomic, metabolomic and computational characterization of pathological conditions, and on how this information may be used to custom tailored treatments based on artificial, bioartificial and tissue engineered organs. (sagepub.com)
- We have a unique combination of expertise in microfluidics, analytical chemistry, toxicology and pharmacology, access to human tissue, and know-how in precision-cut tissue slices of several organs, all under one roof. (hdmt.technology)
- Keeping the ovary cells in a capsule should stop the patient rejecting the artificial ovary, and allow functional ovarian tissue from donors to be used to engineer bioartificial ovaries for women whose ovaries aren't functioning. (medicalnewstoday.com)
Transplant2
- For those with genetic illnesses, however, such as cystic fibrosis, muscular dystrophy and some cancers, organs made from their cells would most likely express the same problems that led the person to need a transplant in the first place. (popsci.com)
- This is because patients will be receiving bioartificial organs needed for transplant. (neoteryx.com)
Rehabilitation1
- Such systems can be based on robotics and automation technology-related paradigms (e.g. surgical robots, devices for physical and cognitive rehabilitation, supporting systems for independent living, etc.) on bionics paradigms (e.g. medical systems which mimic living organisms or technologies that intimately interact with the human body), or the combinations of them, e.g. robotic artificial organs and other active implantable devices featuring direct interfaces to the human body. (ieee-tmrb.org)
20221
- Data Bridge Market Research analyses that the bioartificial organ manufacturing market which was USD 23.13 billion in 2022, is expected to reach USD 42.03 billion by 2030, at a CAGR of 7.75% during the forecast period 2023 to 2030. (agfuse.com)
19991
- In 1999 he first made a bladder for a patient from the patient's own stem cells and is working to adapt the technique for kidneys and other organs. (popsci.com)
Developing1
- Our extensive experience in developing drugs and studying organ-drug response both pharmacologically and toxicologically in several organs in the body is a valuable addition to the existing expertise of the hDMT consortium. (hdmt.technology)
Researchers1
- The researchers see this ability to allow the body's own feedback mechanisms to control the release of ovarian hormones as another potential advantage of the bioartificial ovary over drug-based HRT. (medicalnewstoday.com)
Donors1
- Anthony Atala, a stem-cell specialist at Wake Forest University, conceived of a different approach than using organs from donors: making custom organs from scratch. (popsci.com)
Systems1
- Although neonates appear to be more immunotolerant to transplanted organs, their immature immune systems combined with immunosuppression increases the risk for infectious complications. (medscape.com)
Immune1
- Unfortunately, 50 million deaths occurs worldwide due to organ shortage, high cost and immune rejection. (atlasofscience.org)
Devices1
- GRIP has excellent, up-to-date facilities for the preparation of biochips and nanofluidic devices for cells and organ-on-a-chip cultures. (hdmt.technology)
Patients2
- And even then, patients may reject the organ or die from opportunistic infections. (popsci.com)
- Doctors now pair organs with patients using a system that matches at least six protein variables, but even that isn't enough to forgo immunosuppressant drugs. (popsci.com)
Healthcare1
- 5] 3D printing has been used in healthcare for Organ decellularisation and recellularisation is of particular manufacturing of hearing aids, prosthetics and dental apparatuses. (who.int)
Technologies1
- A Special Interest Group (SIG) has been launched in GRIP to join forces in the development and application of new organ-on-a chip and other adjacent micro-, nano- and 3D-culture technologies. (hdmt.technology)
Treat1
- It's testing a bioartificial pancreas to treat diabetes: a plastic cartridge holding millions of cells that can release insulin in flux with the body's need. (popsci.com)
Approach1
- Opara says they are already working on the next step, which is to evaluate the bioartificial ovary approach in animals. (medicalnewstoday.com)
Details1
- The bioartificial organ manufacturing market competitive landscape provides details by competitor. (agfuse.com)
Focus1
- The above data points provided are only related to the companies' focus related to bioartificial organ manufacturing market. (agfuse.com)
Animals1
- A simpler and perhaps more inclusive solution may be to coax bodies to accept a wider variety of organs (possibly including those from nonhuman animals). (popsci.com)