Bioartificial Organs: Artificial organs that are composites of biomaterials and cells. The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin.Liver, Artificial: Devices for simulating the activities of the liver. They often consist of a hybrid between both biological and artificial materials.Artificial Organs: Devices intended to replace non-functioning organs. They may be temporary or permanent. Since they are intended always to function as the natural organs they are replacing, they should be differentiated from PROSTHESES AND IMPLANTS and specific types of prostheses which, though also replacements for body parts, are frequently cosmetic (EYE, ARTIFICIAL) as well as functional (ARTIFICIAL LIMBS).Kidneys, Artificial: Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE.Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.Bioreactors: Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.Glycogen Storage Disease: A group of inherited metabolic disorders involving the enzymes responsible for the synthesis and degradation of glycogen. In some patients, prominent liver involvement is presented. In others, more generalized storage of glycogen occurs, sometimes with prominent cardiac involvement.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Extracorporeal Circulation: Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.Pancreas, Artificial: Devices for simulating the activity of the pancreas. They can be either electromechanical, consisting of a glucose sensor, computer, and insulin pump or bioartificial, consisting of isolated islets of Langerhans in an artificial membrane.Swine, Miniature: Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Equipment Design: Methods of creating machines and devices.Ammonia: A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.MassachusettsHospitals, General: Large hospitals with a resident medical staff which provides continuous care to maternity, surgical and medical patients.BostonTissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Hand Transplantation: The transference of a complete HAND, as a composite of many tissue types, from one individual to another.Electrophoresis, Microchip: A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.Cost Savings: Reductions in all or any portion of the costs of providing goods or services. Savings may be incurred by the provider or the consumer.Support Vector Machines: Learning algorithms which are a set of related supervised computer learning methods that analyze data and recognize patterns, and used for classification and regression analysis.Renal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Peritoneal Dialysis: Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.Thinking: Mental activity, not predominantly perceptual, by which one apprehends some aspect of an object or situation based on past learning and experience.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Codon, Nonsense: An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Tissue Scaffolds: Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Economic Competition: The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.Health Care Sector: Economic sector concerned with the provision, distribution, and consumption of health care services and related products.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Polyesters: Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.Biomimetic Materials: Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)Bioengineering: The application of engineering principles and methods to living organisms or biological systems.Elastic Cartilage: A type of CARTILAGE whose matrix contains ELASTIC FIBERS and elastic lamellae, in addition to the normal components of HYALINE CARTILAGE matrix. Elastic cartilage is found in the EXTERNAL EAR; EUSTACHIAN TUBE; EPIGLOTTIS; and LARYNX.Biomedical Engineering: Application of principles and practices of engineering science to biomedical research and health care.

Excitability and contractility of skeletal muscle engineered from primary cultures and cell lines. (1/58)

The purpose of this study was to compare the excitability and contractility of three-dimensional skeletal muscle constructs, termed myooids, engineered from C2C12 myoblast and 10T1/2 fibroblast cell lines, primary muscle cultures from adult C3H mice, and neonatal and adult Sprague-Dawley rats. Myooids were 12 mm long, with diameters of 0.1-1 mm, were excitable by transverse electrical stimulation, and contracted to produce force. After approximately 30 days in culture, myooid cross-sectional area, rheobase, chronaxie, resting baseline force, twitch force, time to peak tension, one-half relaxation time, and peak isometric force were measured. Specific force was calculated by dividing peak isometric force by cross-sectional area. The specific force generated by the myooids was 2-8% of that generated by skeletal muscles of control adult rodents. Myooids engineered from C2C12-10T1/2 cells exhibited greater rheobase, time to peak tension, and one-half relaxation time than myooids engineered from adult rodent cultures, and myooids from C2C12-10T1/2 and neonatal rat cells had greater resting baseline forces than myooids from adult rodent cultures.  (+info)

Injectable gels for tissue engineering. (2/58)

Recently, tissue engineering approaches using injectable, in situ gel forming systems have been reported. In this review, the gelation processes and several injectable systems that exhibit in situ gel formation at physiological conditions are discussed. Applications of selected injectable systems (alginate, chitosan, hyaluronan, polyethylene oxide/polypropylene oxide) in tissue engineering are also described. Injectable polymer formulation can gel in vivo in response to temperature change (thermal gelation), pH change, ionic cross-linking, or solvent exchange. Kinetics of gelation is directly affected by its mechanism. Injectable formulations offer specific advantages over preformed scaffolds such as: possibility of a minimally invasive implantation, an ability to fill a desired shape, and easy incorporation of various therapeutic agents. Several factors need to be considered before an injectable gel can be selected as a candidate for tissue engineering applications. Apart from tissue-specific cell-matrix interactions, the following gel properties need to be considered: gelation kinetics, matrix resorption rate, possible toxicity of degradation products and their elimination routes, and finally possible interference of the gel matrix with histogenesis.  (+info)

Tissue engineering strategies for adipose tissue repair. (3/58)

Tissue engineering is a relatively young field that combines engineering, clinical science, and life sciences to, in part, repair or regrow tissues. Adipose tissue has recently become a focus area for tissue engineering, encouraged by the large number of reconstructive, cosmetic, and correctional indications that could be addressed with clinically translatable adipose tissue engineering strategies. This review discusses the three aspects of an adipose construct, namely cell types, scaffold, and microenvironment, and presents current tissue engineering strategies under pursuit.  (+info)

Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart. (4/58)

Achieving the lofty goal of developing a tissue engineered heart will likely rely on progress in engineering the various components: blood vessels, heart valves, and cardiac muscle. Advances in tissue engineered vascular grafts have shown the most progress to date. Research in tissue-engineered vascular grafts has focused on improving scaffold design, including mechanical properties and bioactivity; genetically engineering cells to improve graft performance; and optimizing tissue formation through in vitro mechanical conditioning. Some of these same approaches have been used in developing tissue engineering heart valves and cardiac muscle as well. Continued advances in scaffold technology and a greater understanding of vascular cell biology along with collaboration among engineers, scientists, and physicians will lead to further progress in the field of cardiovascular tissue engineering and ultimately the development of a tissue-engineered heart.  (+info)

Tissue engineering in plastic reconstructive surgery. (5/58)

Tissue engineering (TE) is a new interdisciplinary field of applied research combining engineering and biosciences together with clinical application, mainly in surgical specialities, to develop living substitutes for tissues and organs. Tissue engineering approaches can be categorized into substitutive approaches, where the aim is the ex vivo construction of a living tissue or organ similar to a transplant, vs. histioconductive or histioinductive concepts in vivo. The main successful approaches in developing tissue substitutes to date have been progresses in the understanding of cell-cell interactions, the selection of appropriate matrices (cell-matrix interaction) and chemical signalling (cytokines, growth factors) for stimulation of cell proliferation and migration within a tissue-engineered construct. So far virtually all mammalian cells can be cultured under specific culture conditions and in tissue specific matrices. Future progress in cell biology may permit the use of pluripotent stem cells for TE. The blueprint for tissue differentiation is the genome: for this it is reasonable to combine tissue engineering with gene therapy. The key to the progress of tissue engineering is an understanding between basic scientists, biochemical engineers, clinicians, and industry.  (+info)

Engineering of vascular ingrowth matrices: are protein domains an alternative to peptides? (6/58)

Anastomotic intimal hyperplasia and surface thrombogenicity are the main reasons for the high failure rate of prosthetic small-diameter vascular grafts. While anastomotic intimal hyperplasia is a multifactorial event, ongoing surface thrombogenicity is primarily caused by the lack of an endothelium, even after years of clinical implantation. After decades of poorly performing synthetic artery-grafts, tissue engineering has emerged as a promising approach to generate biologically functional bio-synthetic hybrid grafts mimicking native arteries regarding the presence of an endothelial lining on the blood surface. "In vitro endothelialization" represented the first generation of such tissue-engineered vascular grafts, utilising cell culture techniques for the creation of a confluent autologous endothelium on ePTFE grafts. The clinical long-term results with this method in almost 200 patients are highly encouraging, showing patencies equal to vein grafts. Since "in vitro endothelialization" requires cell culture facilities, it will always be confined to large centres. Therefore, research of the 1990s turned to the development of spontaneously endothelializing implants, to make tissue-engineered grafts amenable to the entire vascular-surgical community. Apart from scaffold designs allowing transmural ingrowth, biological signalling through a facilitating ingrowth matrix holds a key to spontaneous endothelialization. In biological signalling, the increasingly deeper understanding of bio-active molecules and the discovery of domains and peptide sequences during the 1980s created the expectation in the 1990s that peptide signalling may be all that is needed. This present review highlights the possible problems associated with such a reductionist approach. Using the fibronectin molecule, we demonstrated that domains may be more suitable modules in tissue engineering than peptide sequences.  (+info)

Peripheral nerve injury: a review and approach to tissue engineered constructs. (7/58)

Eleven thousand Americans each year are affected by paralysis, a devastating injury that possesses associated annual costs of $7 billion (American Paralysis Association, 1997). Currently, there is no effective treatment for damage to the central nervous system (CNS), and acute spinal cord injury has been extraordinarily resistant to treatment. Compared to spinal cord injury, damage to peripheral nerves is considerably more common. In 1995, there were in excess of 50,000 peripheral nerve repair procedures performed. (National Center for Health Statistics based on Classification of Diseases, 9th Revision, Clinical Modification for the following categories: ICD-9 CM Code: 04.3, 04.5, 04.6, 04.7). These data, however, probably underestimate the number of nerve injuries appreciated, as not all surgical or traumatic lesions can be repaired. Further, intraabodominal procedures may add to the number of neurologic injuries by damage to the autonomic system through tumor resection. For example, studies assessing the outcome of impotency following radical prostatectomy demonstrated 212 of 503 previously potent men (42%) suffered impotency when partial or complete resection of one or both cavernosal nerve(s). This impotency rate decreased to 24% when the nerves were left intact (Quinlan et al., J. Urol. 1991;145:380-383; J. Urol. 1991;145:998-1002).  (+info)

Self-assembly and mineralization of peptide-amphiphile nanofibers. (8/58)

We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone.  (+info)

*Cell encapsulation

Renken A, Hunkeler D (1998). "Microencapsulation: a review of polymers and technologies with a focus on bioartificial organs". ... Hunkeler D (November 2001). "Allo transplants xeno: as bioartificial organs move to the clinic. Introduction". Annals of the ... However, the two major hurdles faced in this technique are the limited availability of donor organs and with the need for ... The potential of using bioartificial pancreas, for treatment of diabetes mellitus, based on encapsulating islet cells within a ...

*Charles Antzelevitch

This bioartificial organ platform is termed a "ghost heart" because of its opaque white appearance. Induced pluripotent stem ... The first step in the organ bioengineering process is decellularization of cadaver hearts using detergents such as sodium ... "Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart". Nature Medicine. 14: 213-221. doi: ... bone marrow or other sources will then be used in an attempt to repopulate the organ and to form a fully functioning human ...

*Sangeeta N. Bhatia

She is the author of Microfabrication in Tissue Engineering and Bioartificial Organs and co-author of the undergraduate ... She studied bioengineering at Brown University where she joined a research group studying artificial organs which convinced her ...

*Tissue engineering

... bioartificial organs and regeneration of injured tissue in the body. In order to successfully create bioartificial organs from ... Bioartificial windpipe: The first procedure of regenerative medicine of an implantation of a "bioartificial" organ. In vitro ... An artificial organ is a man-made device that is implanted or integrated into a human to replace a natural organ, for the ... Recent research on organ printing is showing how crucial a good control of the 3D environment is to ensure reproducibility of ...

*Biomedical engineering

Bioartificial organs, which use both synthetic and biological component, are also a focus area in research, such as with ... One of the goals of tissue engineering is to create artificial organs (via biological material) for patients that need organ ... "Doctors grow organs from patients' own cells". CNN. April 3, 2006. Trial begins for first artificial liver device using human ... Beyond modeling organs and the human body, emerging engineering techniques are also currently used in the research and ...

*List of MeSH codes (E07)

... artificial organs MeSH E07.858.082.050 --- artificial limbs MeSH E07.858.082.212 --- bioartificial organs MeSH E07.858.082.374 ...

*Korkut Uygun

... utilize untransplantable organs as cell sources for cell transplantation or bioartificial organ substitutes, such as ... bioartificial livers, and if the organ proves completely unresuscitatable, utilize them as biocompatible scaffodls for tissue ... In 2008, Uygun was awarded a Career Award by NIDDK at NIH "Computer-Aided Development of a Liver Organ Culture System". In 2009 ... A major research objective of Uygun is to enhance utilization of discarded donor organs in order to either increase the supply ...

*Bioartificial heart

Highfield, Roger (January 13, 2008). "First bioartificial heart may signal end of organ shortage". The Telegraph. Retrieved ... The first bioartificial hearts were created in 2008 using cadaveric rat hearts. In 2014, human-sized bioartificial pig hearts ... Often, the only viable treatment for end-stage heart failure is organ transplantation. Currently organ supply is insufficient ... A bioartificial heart is an engineered heart that contains the extracellular structure of a decellularized heart and cellular ...

*Regeneration in humans

... and implanting bioartificial tissues. In 1999 the bladder was the first regenerated organ to be given to seven patients; as of ... The first organ ever induced and made in the lab was the bladder, which was created in 1999. In 2014, organs that have been ... Researchers, from University of Edinburgh, have succeeded in regenerating a living organ. Regenerated organ is closely ... Like other organs, the kidney is also known to regenerate completely in lower vertebrates such as fish. Some of the known fish ...

*Liver support systems

Safety barrier between a patients blood and a bioartificial liver". The International Journal of Artificial Organs. 19 (11): ... "Phase I clinical trial with the AMC-bioartificial liver". The International Journal of Artificial Organs. 25 (10): 950-9. PMID ... clinical results of a new membrane-based blood purification system for bioartificial liver support". Artificial Organs. 23 (4 ... Bio-artificial liver (BAL) Hepatassist 2000 uses porcine hepatocytes11 whereas ELAD system employs hepatocytes derived from ...

*Liver dialysis

... for Artificial Internal Organs and European Society for Artificial Organs Artificial extracorporeal liver support Bioartificial ... Like a bioartificial liver device, it is a form of artificial extracorporeal liver support. A critical issue of the clinical ... van de Kerkhove MP, Hoekstra R, Chamuleau RA, van Gulik TM (August 2004). "Clinical application of bioartificial liver support ... Liver Support Working Group of the European Society for Artificial Organs (ESA0) Information on different Liver Dialysis ...

*Artificial organ

HepaLife is developing a bioartificial liver device intended for the treatment of liver failure using stem cells. The ... RFID tags). Organ chips are devices containing hollow microvessels filled with cells simulating tissue and/or organs as a ... "Artificial Organs". Reference.MD. RES, Inc. 6 June 2012. Retrieved 16 March 2016. Tang, R. (1998). "Artificial Organs". Bios. ... Artificial bone, skin, uterus, kidney Biomechatronics Biomedical Engineering Decellularization Organ transplant Organ culture ...

*Decellularization

... ranging from end organ failure to cosmetic surgery. One of the greatest limitations to organ transplantation derives from organ ... Ott, H.C (2008). "Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart". Nature Medicine ... which can be used in artificial organ and tissue regeneration. Organ and tissue transplantation treat a variety of medical ... Complete organ reconstruction is still in the early levels of development. Researchers are able to take the tissue from a donor ...

*Doris Taylor

She is Director, Regenerative Medicine Research and Director, Center for Cell and Organ Biotechnology at the Texas Heart ... al (February 2008). "Perfusion- decellularized: Using Nature's Platform to Engineer Bioartificial Heart". Nat Med. 14 (2): 213- ... research which has uncovered differences in the underlying framework of male and female hearts and other vital organs. Maggie ...

*Thorsten Walles

Being a thoracic surgeon, he focused on the generation of bioartificial airway tissues for tracheo-bronchial replacement. His ... Young Investigator Award of the World Heart Federation 2003 Young Researcher Award of the European Society of Artificial Organs ... Tissue remodelling in a bioartificial fibromuscular patch following transplantation in a human. Transplantation. 2005; 80: 284- ... transplanted patients Walles and his coworkers demonstrated a post-transplant tissue-maturation process of the bioartificial ...

*Liver transplantation

The most common technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ ... Artificial liver support like liver dialysis or bioartificial liver support concepts are currently under preclinical and ... The immunosuppressive regimens for all solid organ transplants are fairly similar, and a variety of agents are now available. ... Early graft failure is probably due to preexisting disease of the donated organ. Others include technical flaws during surgery ...

*Cardiomyoplasty

Washed off cells reach other organs or die, which can be an issue at the time of prepare ICH module 8. Other alternative ... using natures platform to engineer a bioartificial heart". Nat. Med. 14: 213-221. doi:10.1038/nm1684. PMID 18193059. Matsuura K ... cell signaling agents to induce the regeneration of an organ or damaged tissue. In an ideal scenario, regenerated tissue would ... genetic and biomedical engineering for regeneration and cell expansion targets to restructure and/or repair human organs. ...

*Neuroregeneration

... recent neural tissue engineering research has focused on the development of bioartificial nerve guidance conduits in order to ... Tissue Engineering and Artificial Organs, J.D. Bronzino, Editor. 2006, Taylor & Francis: New York YIU, G. & ZHIGANG, H. (2006 ...

*Islet cell transplantation

To circumvent this organ shortage problem, researchers continue to look for ways to "grow" islets-or at least cells capable of ... This is reported to be done in the "bioreactor" ßAir, a "proprietary implantable bioartificial pancreas" developed by Israel- ... "Chronic renal failure after transplantation of a nonrenal organ". N Engl J Med. 349 (10): 931-940. doi:10.1056/NEJMoa021744. ...

*Neurotrophic factors

The NT-3 protein is found within the thymus, spleen, intestinal epithelium but its role in the function of each organ is still ... Currently, neurotrophic factors are being intensely studied for use in bioartificial nerve conduits because they are necessary ...

*Artificial pancreas

the bioengineering approach-the development of a bio-artificial pancreas consisting of a biocompatible sheet of encapsulated ... official journal of the Middle East Society for Organ Transplantation. 13 Suppl 1: 37-45. PMID 25894126. Gingras, V; Taleb, N; ...

*Paolo Macchiarini

In 2016 she underwent multiple organ transplants in the U.S., and her trachea was replaced with one from a cadaver. Cetir died ... "Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study". Lancet. 378 ( ... He obtained degree certificates-a masters in organ and tissue transplantation dated 1994 and a doctorate in the same dated 1997 ... Fountain, Henry (15 September 2012). "Scientists Make Progress in Tailor-Made Organs". The New York Times. p. 1. Fountain, ...

*2015 in science

It is hoped this technique could ultimately help damaged organs and nerves to repair themselves and help transplanted organs to ... "Engineered composite tissue as a bioartificial limb graft". Biomaterials. 61: 246-256. doi:10.1016/j.biomaterials.2015.04.051. ...
Get latest Market Research Reports on Asia-Pacific Bio-Artificial Pancreas. Industry analysis and Market Report on Asia-Pacific Bio-Artificial Pancreas is a syndicated market report, published as Asia-Pacific Bio-Artificial Pancreas Market Assessment 2020-2026. It is complete Research Study and Industry Analysis of Asia-Pacific Bio-Artificial Pancreas market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.
Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
The Kidney Project is a national research project with a goal to create a small, surgically implanted, and free-standing bioartificial kidney to treat end stage renal disease (ESRD).. The bioartificial kidney will give ESRD patients new hope beyond the short-term solution of renal dialysis and the longer-term, but impermanent, solution of a living kidney transplant for which donor organs are limited.. Subsequently, the bioartificial kidney is expected to save national health care dollars.. ...
We developed a bioartificial tissue (TraVaSc-TERM ®) for the surgical reconstruction of extensive tracheo-bronchial defects including circumferent airway replacement. The tissue is generated from a xenogene biological scaffold [pig intestine, -LS] that is decellularized, preserving the structure of the vascular network. For transplant generation, these vascular structures are reseeded with autologous endothelial precursor cells of the recipient. Two more autologous cell types are needed to generate a functional airway substitute. Our approach results in a vascularized autologous transplant tissue that can be connected to the recipients blood supply at time of implantation to guarantee transplant survival. Tissue generation takes about five weeks. The TraVaSc-TERM ® was applied successfully in three patients between 2006 and 2009 [actually, it seems one patient was counted as two, -LS]. As a result of the ATMP-legislation in Europe the TraVaSc-TERM ®-generation process had to be transferred ...
... on Wyss Institute | Screened at the symposium opening, this animation artistically connects concepts of…
The renal assist device (RAD) is a bioartificial kidney -- a device lined with human renal tubular cells grown from donated organs. Even with conventiona
Bioartificial Heart: A Human-Sized Porcine Model - The Way Ahead. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
University of Pittsburgh researchers have initiated a clinical study of a bio-artificial liver assist device that is intended to support patients with acute liver failure until human organs can be found for transplantation...
Russian scientists have created a bioartificial liver based on cellular technologies. As a result of its transplantation the functions of a damaged liver may be almost completely restored.
In this field of research, the challenges (scientific and technological) are big. There is need for new biomaterials, need for better understanding and tailoring of the biomaterial - cell / tissue interaction, better immune protection and mass transfer, as well as, development of new concepts and designs. The complexity increases from artificial to bioartificial organs, and the engineering and regulatory demands increase further if these organs would be extracorporeal or implantable.. The chair of (bio) artificial organs addresses several of these challenges by developing an innovative research program, which combines a wide spectrum of disciplines: from molecule to organ.. ...
Bat E, Plantinga JA, Harmsen MC, van Luyn MJ, Feijen J, and Grijpma DW. (2010). In vivo behavior of trimethylene carbonate and epsilon-caprolactone-based (co)polymer networks: degradation and tissue response. J Biomed Mater Res A 95: 940-9. PubMed. Bat E, Harmsen MC, Plantinga JA, van Luyn MJ, Feijen J, and Grijpma DW. (2010). Flexible scaffolds based on poly(trimethylene carbonate) networks for cardiac tissue engineering. J Control Release 148: e74-e76. PubMed. Dankers PY, Boomker JM, der Vlag AH, Smedts FM, Harmsen MC, and van Luyn MJ. (2010). The use of fibrous, supramolecular membranes and human tubular cells for renal epithelial tissue engineering: towards a suitable membrane for a bioartificial kidney. Macromol Biosci 10: 1345-54. PubMed. Hosper NA, Eggink AJ, Roelofs LA, Wijnen RM, van Luyn MJ, Bank RA, Harmsen MC, Geutjes PJ, Daamen WF, van Kuppevelt TH, Tiemessen DM, Oosterwijk E, Crevels JJ, Blokx WA, Lotgering FK, van den Berg PP, and Feitz WF. (2010). Intra-uterine tissue engineering ...
Bernhard Jank et al, "Engineered Composite Tissue as a Bioartificial Limb Graft, Biomaterials (August 2015), 61:246-56. The abstract reads as follows: "The loss of an extremity is a disastrous injury with tremendous impact on a patients life. Current mechanical prostheses are technically highly sophisticated, but only partially replace physiologic function and aesthetic appearance. As a biologic alternative, approximately 70 patients have undergone allogeneic hand transplantation to date worldwide. While outcomes are favorable, risks and side effects of transplantation and long-term immunosuppression pose a significant ethical dilemma. An autologous, bio-artificial graft based on native extracellular matrix and patient derived cells could be produced on demand and would not require immunosuppression after transplantation. To create such a graft, we decellularized rat and primate forearms by detergent perfusion and yielded acellular scaffolds with preserved composite architecture. We then ...
An emerging treatment for patients with failing valves, TVR entails implanting a prosthetic valve through the skin, using catheterization to forgo more invasive surgery. Going through the groin area, a catheter containing a replacement valve is guided to the location of the failing valve. Canic says the stent holding this bioartificial valve is made of a shape memory alloy that assumes a predefined shape optimized for TVR procedures once it reaches the patients body temperature of 98.6 degrees Fahrenheit. When the catheter reaches the location of the failing valve, the stent expands and anchors the bioartificial valve in place.. ...
Bioartificial liver. This innovation helps patients cope as they await a donor liver. Developed by Mayo Clinic doctors and researchers, new bioartificial livers use living cells from pig livers to filter a patients blood in a process similar to that of kidney dialysis. The device is being tested before it becomes available in clinics and hospitals ...
Information on the types of data captured in CORR, data supply chain, coverage, under-reporting, non-response, reliability/response bias, methodological changes and revision history.
The adoption of xenotransplantation has been hampered by inherent fears of immune responses and transfer of animal pathogens to humans. Novel solutions are required to isolate the transplanted cells from the patient in order to enable continued advancement of this field. βAir is an ideal solution.. βAir is presently being tested in pre-clinical studies for xenotransplantation without immunosuppressive drugs.. On February 19, 2015, the company announced (click here to view press release) the same system being used to treat type 1 diabetes patients in the clinical trial in Sweden (click here to see press release), also appears to work well for other types of functional cells, such as adrenal cells. The results of a series of pre-clinical studies demonstrated that using ßAir, pig adrenal cells can be transplanted into a living being other than a pig and still remain healthy and function properly. This means that the companys ßAir Bio-artificial Adrenal device could offer a treatment for ...
Ludwig B, et al. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A. 2012;109:5022-7.. ...
Researchers from the Indian Institute of Technology, Bombay, develop a polymer based bioartificial pancreas which can be implanted into the body to help diabetic patients.. ...
If you or I are in need of an organ replacement these days, the only means of obtaining that organ is by way of a donation; either by a living person (if the organ is paired, or can be partly donat ...
Interactive table providing the annual number of end-stage kidney disease patients registered in the Canadian Organ Replacement Register on December 31 by treatment modality and province of treatment, 2006 to 2015. ...
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Based on a technology licensed through The Ohio State University, Nanofiber Solutions is a global developer, manufacturer and marketer of 3-D products to advance life science research, tissue engineering and regenerative medicine. The company develops nanofiber-based scaffolds used in products ranging from cell culture plates for lab research to bioartificial implants for clinical use. Nanofiber Solutions sells our cell culture products worldwide through our website and distribution partners; including Sigma-Aldrich (worldwide), Neuromics (US), Akron Biotech (US), and Cambridge BioScience (UK). Nanofiber Solutions is located in the TechColumbus center in Columbus, OH ...
IIT Guwahati researchers have created a bioartificial liver model grown within a 3D silk scaffold. The scaffold made by mixing mulberry and non-mulberry silk fibroins showed enhanced liver-specific functions. When implanted in animals, the scaffold was found to be biocompatible. The researchers are now validating the scaffold with primary human liver cells and human stem cell-derived liver…
Spin-out regenerative medicine company, Videregen, has received £400,000 in follow on funding from The North West Fund for Biomedical, managed by SPARK Impact.. Based at Liverpool Science Park, the companys core technology uses decellularised organ scaffolds seeded with patients own stem cells to create non-immunogenic, regenerative bespoke organ replacements.. This new round of funding follows on from an original £900,000 investment from The North West Fund for Biomedical in 2014. The business leveraged this investment to further develop its lead product for trachea replacement, which aims to become the worlds first commercially available tissue engineered stem cell organ replacement product. Based on the same core platform technology, the follow on funding enables the Company to progress work on its bowel replacement programme.. Dr Marc dAbbadie of SPARK Impact, said: "The developments Videregen is making into improving regenerative medicine are potentially groundbreaking. SPARK Impact ...
Due to his experience working with stem cells, Cady was recruited for a pivotal role in a groundbreaking surgery that occurred in April 2013. He provided the technical expertise necessary to successfully generate a tissue-engineered bioartificial trachea for transplant into 2-year-old Hannah Warren - the first such transplant in the United States.. When Warren was born, the doctors in her Seoul, South Korea-based hospital noticed she was blue and immediately inserted a tube from her throat to her lungs, so she could breathe. A CT scan revealed she was born with tracheal agenesis - the lack of a complete trachea. This condition required Warren to have both breathing and feeding tubes to live.. Dr. Mark Holterman, a pediatric surgeon at Childrens Hospital of Illinois, learned of Warrens plight while on a business trip in Seoul. He soon returned to meet with her parents, Darryl and Young Mi, offering to help find a solution that might save the girl; it took him two years to make the surgery a ...
Assist organ replacements and biotechnology research: Human organs are known to fail due to a variety of reasons like illness or injury putting lives at risk. Genetic engineering provides the fundamental basis for the process of transplanting organs or living tissues from animals to human beings. Already, there have been huge advancements in the science of transplanting organs from pigs to humans for replacing damaged hearts and kidneys. There is also a great sense of anticipation for the expected breakthroughs in tissue engineering that will pave the way for alternatives to cartilage replacement, heart valves, cerebrospinal shunts, and more.. Help to eradicate global shortage of food: Right from increasing crop productivity to making seeds and plants more insect and pest-resistant to produce with improved size, taste, sweetness, genetic modification of food crops and fruits has been hailed as one of the biggest steps taken by making to eradicate the shortage of foods world over.. Help get rid ...
Prestigious New York surgical hospital adopts new product to focus on safety and efficiency of tissues.. LENEXA, KS November 4, 2008 - Mediware Information Systems, Inc. (Nasdaq: MEDW) announced that the Hospital for Special Surgery has licensed BiologiCare™, the Companys latest product focused on the safe and efficient management of bones, tissues and other biologic products used in surgeries and other patient therapies. Released in June 2008 as one of Mediwares growth initiatives, BiologiCare leverages the Companys more than 25 years of blood management experience to address emerging needs within the hospital. BiologiCare is the first commercial-grade system available in the United States that is designed specifically to track and trace these materials.. Driving the need for BiologiCare are an estimated 10 million transplantation procedures that have now been performed. Hospital procedures range from the use of bone chips, tendons and other tissues in surgeries, organ replacements, and ...
Kodaira Y, Nair SK, Wrenshall LE, Gilboa E, Platt JL. Phenotypic and functional maturation of dendritic cells modulated by heparan sulfate. J Immunol 165:1599, 2000.. Dempsey LA, Brunn GJ, Platt JL. Heparanase, a potential regulator of cell-matrix interactions.Trends Biochem Sci 25:349, 2000.. Saadi S, Holzknecht RA, Patte CP, Platt JL. Endothelial cell activation by pore-forming structures: pivotal role for IL-1a. Circulation 101:1867, 2000.. Holzknecht ZE, Platt JL.The fine cytokine line between graft acceptance and rejection. Nat Med 6: 497, 2000.. Platt JL. Xenotransplantation: new risks and new gains. Nature 407:27, 2000.. Cascalho M, Platt JL. The immunological barrier to xenotransplantation. Immunity 14:437, 2001.. Cascalho M, Platt JL. Xenotransplantation and other means of organ replacement. Nat Rev Immunol1:154, 2001.. Platt JL. Knocking out xenograft rejection. Nat Biotechnol 20:231, 2002.. Johnson GB, Brunn GJ, Kodaira Y, Platt JL. Receptor-mediated monitoring of tissue well being ...
In his recent piece in iPolitics, Wayne Kondro correctly indicates that organ donation and transplant performance in Canada continue to lag well behind other countries. While we have seen some improvements - as noted in the recent Canadian Organ Replacement Register (CORR) annual report - we agree more work needs to be done to meet the needs of patients. ...
Our team of talented medical artists were pleased to work on a recent project for Videregen, producing highly accurate medical illustrations of the trachea to help explain the trachea organ replacement process.
OBJECTIVE: To analyze the effects of an extracorporeal bioartificial liver containing alginate bead-entrapped hepatocytes on pigs with ischemia-induced acute hepatic failure. DESIGN: Prospective animal study. SETTING: University and INSERM laboratory. SUBJECTS: Fifteen Large White/Pietrin female pigs weighing 20-30 kg. INTERVENTIONS: Acute hepatic failure was induced by end-to-side portocaval shunt and ligature of the whole porta hepatitis. The bioartificial liver was in a thermostabilized column, containing a fluidized bed of alginate beads that embedded porcine hepatocytes, connected to a plasmapheresis system. Intracranial pressure; survival; ammonia, total bilirubin, aminotransferases, alkaline phosphatase, and lactate concentrations; and clotting factors were studied. The groups were pigs with acute hepatic failure (group 1, n = 4), pigs with acute hepatic failure treated with bioartificial liver containing empty beads (group 2, n = 4), or porcine hepatocytes (group 3, n = 5). MEASUREMENTS ...
Nanoporous membranes engineered to mimic natural filtration systems can be used in smart implantable drug delivery systems, bioartificial organs, and other novel nano-enabled medical devices. The ultrananocrystalline diamond (UNCD) porous membranes will open new opportunities in implant medicine because of the highest, unmatched by other materials degree of biocompatibility and anti-biofouling. We report our results on high porosity high-aspect-ratio UNCD membranes fabricated using e-beam lithography, reactive ion etching and laser writing.
Artificial kidney is often a synonym for hemodialysis, but may also, more generally, refer to renal replacement therapies (with exclusion of kidney transplantation) that are in use and/or in development. This article deals with bioengineered kidneys/bioartificial kidneys that are grown from renal cell lines/renal tissue. The first successful artificial kidney was developed by Willem Kolff in the Netherlands during the early 1940s. Kolff was the first to construct a working dialyzer in 1943. Kidneys are paired vital organs located behind the abdominal cavity at the bottom of the ribcage corresponding to the levels T12-L3 of the spine vertebrae. They perform about a dozen physiologic functions and are fairly easily damaged. Some of these functions include filtration and excretion of metabolic waste products, regulation of necessary electrolytes and fluids and stimulation of red blood cell-production. These organs routinely filter about 100 to 140 liters of blood a day to produce 1 to 2 liters of ...
Journal of Nanomaterials is a peer-reviewed, Open Access journal that aims to bring science and applications together on nanoscale and nanostructured materials with emphasis on synthesis, processing, characterization, and applications of materials containing true nanosize dimensions or nanostructures that enable novel/enhanced properties or functions. It is directed at both academic researchers and practicing engineers. Journal of Nanomaterials will highlight the continued growth and new challenges in nanomaterials science, engineering, and nanotechnology, both for application development and for basic research. All papers should emphasize original results relating to experimental, theoretical, computational, and/or applications of nanomaterials ranging from hard (inorganic) materials, through soft (polymeric and biological) materials, to hybrid materials or nanocomposites.
Supported by an RPB Unrestricted Grant to the University of Washington School of Medicine, Dr. Jennifer Chao is assessing the ability of thousands of small molecules to enhance the survival of retinal cells created from AMD patient-specific stem cells. This is an important step in discovering disease- and patient-specific therapeutic drugs.. The idea that stem cells - the precursors of all body tissues - could be turned into organ replacements for diseased body parts has tantalized physicians and patients for decades. Scientists have been able to increase the availability of stem cells by developing techniques to transform a patients skin and blood cells into a primitive stem cell state from which all forms of human cells can, theoretically, be coaxed. These human induced pluripotent stem cells (hIPSC) have the added benefit of appearing to the patients immune system as native tissue and avoiding attack by the bodys immune response.. Ultimately, vision researchers hope to use a patients own ...
Many thanks to the 33 alumni (and friends) who returned to Muhlenberg on Sunday, February 20, 2005, to speak to students as part of this years Career Campaign, the Office of Career Development and Placements half-day career conference for students. Special thanks to Dana Diorio 93 for delivering an inspiring keynote address to kick off the campaign!. Josh Brookstein 03, Teacher, NYC Department of Education • Frank Caria 01, Organ Replacement Coordinator, New York Organ Donor Network • Victoria Cioce 03, Life & Health Coordinator, Owens Group Limited, Inc. • Elizabeth Coleman 99, Law Student, Villanova University • Marisa Cox 00, Research Associate, George Washington University, Center for Health Services • Matt Daly 98, Divisional Vice President of Equities, UBS Financial Services • Dana Diorio, 93 Keynote Speaker, Sales Manager, Xerox Corporation • Jennifer Epting 03, Development Associate, French-American School of New York • George Ericsson 81, Associate Director ...
3D bioprinting has begun to show great promise in advancing the development of functional tissue/organ replacements. However, to realize the true potential of 3D bioprinted tissues for clinical use requires the fabrication of an interconnected and ef ...
... https://www.sciencedaily.com/releases/2017/11/171114092052.htm Researchers are developing a first-of-its-kind bioengineered robotic hand that will actually feel and adapt to its environment. This
... https://www.sciencedaily.com/releases/2017/11/171114092052.htm Researchers are developing a first-of-its-kind bioengineered robotic hand that will actually feel and adapt to its environment. This
cylonlover writes Heart transplants have given new life to thousands, but are only an unfulfilled hope to thousands more due to a shortage of donor organs. With the goal of meeting this shortfall, scientists at the University of Pittsburgh School of Medicine have bioengineered a mouse heart in the ...
Scientists have invented a speedy method to make potent painkilling opioids using bioengineered bakers yeast instead of poppies.
Reporting in Nature Communications, the research team suggests that the cell-based system of hormone replacement, because of its ability to match dose with the bodys needs, is an attractive alternative to drugs and is consistent with current guidelines in the U.S. and Europe recommending the lowest possible doses of hormone replacement therapy.. Safe hormone replacement will likely become increasingly important as the population of aging women grows, said Opara. Whether the loss of ovarian function is due to surgical removal, chemotherapy or menopause, the effects can range from hot flashes and vaginal dryness to infertility and increased risk of osteoporosis and heart disease.. To engineer the bioartificial ovary, the research team isolated the two types of cells found in ovaries (theca and granulosa) from rats. A thin membrane was used as a capsule to contain the cells and then implanted in rats that had their ovaries removed. These rats were compared with animals with normal ovarian ...
Diabetes type 1 is a widespread endocrine disorder with a significant social and economic impact. It is characterized by autoimmune destruction of β cells, which results in inadequate insulin secretion and an abnormally high level of blood glucose. Transplantation of pancreatic islets has emerged as a promising procedure for the treatment of patients with type 1 diabetes, but the procedure is inefficient and the results are not satisfactory yet. My project focuses on the possibilities of using microfluidics and hydrogels combined to improve this treatment. I aim to setup a workable and highly efficient technology platform, combining microfluidics and hydrogels, which can greatly assist in the development of a bioartificial pancreas. ...
Tweet. How many parents does it take to change a lipid? In some cases, it takes "three parents". Recent news in the British media has highlighted a debate about ethics in assisted conception. The Human Fertilisation and Embryology Authority (HFEA) has initiated a consultation about the public response to what has been dubbed "3 parent IVF". This debate has been regarded as moot by informed scientists, as the "third parent" in this case provides no human DNA at all, but is a supply of healthy symbiotic organelles called mitochondria. This procedure is thus equivalent to organ replacement, though it takes place at cellular level. This sort of intervention is well known as a serious undertaking, and begs the question of what sort of problems could require such an intervention. A surprising number are lipid-based.. The lipid basis for mitochondrial disease has far-reaching physical and metabolomic consequences as, unlike most organelles, the correct chemical activity of a mitochondrion relies upon ...
It is commonly stated that tissue engineering is the most promising approach to treat or replace failing tissues/organs. For this aim, a specific strategy should be planned including proper selection of biomaterials, fabrication techniques, cell lines, and signaling cues. A great effort has been pursued to develop suitable scaffolds for the restoration of a variety of tissues and a huge number of protocols ranging from|i| in vitro|/i| to|i| in vivo|/i| studies, the latter further differentiating into several procedures depending on the type of implantation (i.e., subcutaneous or orthotopic) and the model adopted (i.e., animal or human), have been developed. All together, the published reports demonstrate that the proposed tissue engineering approaches spread toward multiple directions. The critical review of this scenario might suggest, at the same time, that a limited number of studies gave a real improvement to the field, especially referring to|i| in vivo|/i| investigations. In this regard, the
LIPREBUILD™ is bioengineered to reverse and restore severely dry, cracked and wrinkled lips using a clinically proven moisture recycling technology.
Abstract. A closed loop, glucose sensing, and insulin responsive system could dramatically improve treatment options for insulin dependent diabetics. Clinical islet transplantation, the intrahepatic loading of allogeneic islets, shows the potential to provide this intimate control, by transplanting the very cells with this inherent glucose sensing/insulin secreting capacity. The success of clinical islet transplantation is hindered by the location of the implant site, which is prone to mechanical stresses, inflammatory responses, and exposure to high drug and toxin loads, as well as the strong inflammatory and immunological response to the transplant in spite of systemic immunosuppression. To address these challenges, we are focused on three primary strategies: the development of scaffolds to house islets at alternative transplant sites; the fabrication of encapsulation protocols for the immuno-camouflage of the transplant; and the production of bioactive biomaterials for the local delivery of ...
The main goal of regenerative medicine (RM) is to restore damaged organs and tissues using molecular, cell and tissue engineering approaches. In this aspect, R...
Info concerning Pickens Technical College bioengineering program. There are a variety of engineering training programs that may appeal to you, such as mechanics, vehicle design, and alternative energy production.
Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications. Edited by: Angelo Carpi. ISBN 978-953-307-268-5, PDF ISBN 978-953-51-4467-0, Published 2011-08-01
食品、飲料與營養保健品 (Yantai Hengyuan Bioengineering Co., Ltd) | 食品、飲料與營養保健品一站式進行配方,數據表,物質安全數據表搜索,產品特性和樣品申請 -- 免費使用
Customized grafts that include a scaffold populated with the patients own cells could become a major advantage in the field of uterus transplantation since it may overcome problematic donor issues...
Yang, Lifeng; Moss, Tyler; Mangala, Lingegowda S.; Marini, Juan; Zhao, Hongyun; Wahlig, Stephen; Armaiz-Pena, Guillermo; Jiang, Dahai; Achreja, Abhinav; Win, Julia; Roopaimoole, Rajesha; Rodriguez-Aguayo, Cristian; Mercado-Uribe, Imelda; Lopez-Berestein, Gabriel; Liu, Jinsong; Tsukamoto, Takashi; Sood, Anil K.; Ram, Prahlad T.; Nagrath, Deepak (2014) ...
A Frankenfood is a food thats been genetically modified or created through bioengineering. Controversy surrounding Frankenfoods...
In a pioneering, first of its kind in the world operation, an international team of surgeons at Childrens Hospital of Illinois created and transplanted a windpipe into a 32-month-old Korean toddler born with a rare, fatal, congenital abnormality in which her trachea failed to develop.. During the revolutionary operation, the surgical team implanted a tissue engineered stem cell based artificial windpipe in Hannah Warren, who had spent her entire life living in a neonatal intensive care unit in a hospital in Seoul, South Korea. Unable to breathe, talk, swallow, eat or drink on her own since birth, Hannah would have died without a trachea transplant.. The groundbreaking, nine hour operation took place at Childrens Hospital of Illinois, part of OSF Saint Francis Medical Center, in Peoria, Illinois, on April 9, 2013. It is the first time a child has received a tissue-engineered, bioartificial trachea, which was made using non-absorbable nanofibers and stem cells from her own bone marrow. Because ...
TY - JOUR. T1 - Optimization of rat hepatocyte culture in citrated human plasma. AU - Washizu,J.. AU - Berthiaume,F.. AU - Chan,C.. AU - Tompkins,R. G.. AU - Toner,M.. AU - Yarmush,M. L.. PY - 2000. Y1 - 2000. N2 - Background. Maintenance of liver-specific functions in hepatocyte cultures during plasma exposure is critical for the clinical application of bioartificial liver assist systems. Sodium citrate is a common anticoagulant but has been shown to be cytotoxic to hepatocytes. We have tested the effect of various supplements on the viability and function of adult primary rat hepatocytes exposed to citrated plasma. Materials and methods. Freshly isolated rat hepatocytes were cultured in the collagen gel sandwich configuration in culture medium for 6 days followed by exposure to citrated human plasma with various supplements for 1 week. Controls were left in culture medium throughout. Viability and synthetic functions were evaluated. Results. Hepatocytes exposed to unsupplemented citrated ...
The HepatAssist liver support system is an extracorporeal porcine hepatocyte-based bioartificial liver (BAL). In this study, researchers from Europe and the United States evaluated the safety and efficacy of the BAL in patients with severe acute liver failure.. The team enrolled a total of 171 patients (86 control and 85 BAL) in the study.. They included patients with fulminant/subfulminant hepatic failure and primary nonfunction following liver transplantation. The team identified liver transplantation, time to transplant, disease etiology, disease severity, and treatment site as possible confounding factors.. The researchers found that 30-day survival was 71% for BAL compared with 62% for the controls.. When the team excluded primary nonfunction patients, they found that survival was 73% for BAL patients and 59% for the controls. When confounding factors were considered, the team found no difference between the 2 groups.. However, survival in fulminant/subfulminant hepatic failure patients was ...
食品、飲料與營養保健品 (Jiangsu Jiecheng Bioengineering Co., Ltd.) | 食品、飲料與營養保健品一站式進行配方,數據表,物質安全數據表搜索,產品特性和樣品申請 -- 免費使用
... Dr. Anna Falabella, assistant professor of dermatology at the University of Miami, holds up a a piece of a new “Bioengineered skin†commercially known as Apligraf, made from a mixture of living human cells and collagen derived from cows.
Researchers at Brown University have created an "artificial human ovary" using a tissue engineering approach that they hope will one day allow scientists to mature human eggs in a laboratory.. SOURCE ...
Information about Loras College bioengineering classes. The field of engineering requires either an associates degree for entry-level technical workers, or a bachelors degree for professional engineers.
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The UK House of Commons Science and Technology Committee has published a report about the UK struggling to translate its research base in bioengineering.
Reporting in Nature Communications the group demonstrate that bioengineered hair follicle germ reconstructed from adult epithelial stem cells and dermal papilla cells can regenerate fully functional hair follicle and hair growth. Their bioengineered follicles showed restored hair cycles and piloerection through the rearrangement of follicular stem cells and their niches. The bioengineered hair follicle also developed the correct structures and formed proper connections with surrounding host tissues such as the epidermis, arrector pili muscle and nerve fibers. This study thus reveals the potential applications of adult tissue-derived follicular stem cells as a bioengineered organ replacement therapy ...
Although hepatocytes have a remarkable regenerative power, the rapidity of acute liver failure makes liver transplantation the only definitive treatment. Attempts to incorporate engineered three-dimensional liver tissue in bioartificial liver devices
This study using Canadian Organ Replacement Registry (CORR) data compared PD survival relative to HD. Overall survival for the study period favored PD in the first 18 months and HD after 36 months. Looking at the 2001-04 cohort, survival favored PD for the first 2 years only and then was similar for both HD and PD. In subgroup analysis, female diabetics over the age of 65 on PD had a 27% higher mortality rate. Overall, the authors concluded HD and PD are associated with similar outcomes in the treatment of ESRD in Canada.. ...
Allogeneic islet transplantation faces difficulties because (i)organ shortage is recurrent; (ii) several pancreas donors are often needed to treat one diabetic recipient; and (iii) the intrahepatic site of islet implantation may not be the most appropriate site. Another source of insulin-producing cells, therefore, would be of major interest, and pigs represent a possible and serious source for obtaining such cells. Pig islet grafts may appear difficult because of the species barrier, but recent reports demonstrate that pig islets may function in primates for at least 6 months. Pig islet xenotransplantation, however, must still overcome several hurdles prior to becoming clinically applicable. The actual consensus is to produce more preclinical data in the pig-to-primate model as a necessary requirement to envisage any pig-to-human transplantation of islets; therefore, a summary of the actual acquired knowledge of pig islet transplantation in primates seemed useful. ...
Description. Includes audio/video content: AV selected lectures, AV special element video. Bioengineering at MIT is represented by the diverse curricula offered by most Departments in the School of Engineering. This course samples the wide variety of bioengineering options for students who plan to major in one of the undergraduate Engineering degree programs. The beginning lectures describe the science basis for bioengineering with particular emphasis on molecular cell biology and systems biology. Bioengineering faculty will then describe the bioengineering options in a particular engineering course as well as the type of research conducted by faculty in the department. Includes audio/video content: AV selected lectures, AV special element video. Bioengineering at MIT is represented by the diverse curricula offered by most Departments in the School of Engineering. This course samples the wide variety of bioengineering options for students who plan to major in one of the undergraduate Engineering ...
Tissue engineering is the combinational usage of cells, engineering, materials methods, suitable biochemical and physicochemical factors in order to improve or replace the infected biological tissues. The field includes the development of materials, devices, techniques to detect and differentiate disease states ,the treatment response, aid tissue healing, precisely deliver treatments to tissues or cells, signal early changes in health status, and provide implantable bio artificial replacement organs for recover or establish of healthy tissue .Techniques developed here identify and detect biomarkers of disease sub-types, progression, and treatment response, from tissue imaging, gene testing and gene analysis, that aid the more rapid development of new treatments and guide their clinical applications in treating the disorder. It includes the usage of computational modelling, bioinformatics and quantitative pharmacology to integrate data from diverse experimental and clinical sources to discover ...
Get info about Centre College bioengineering program. Are you are considering an associates degree in electronics engineering, or a bachelor of science in mechanical or civil engineering?
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Bioengineering combines the analytical and experimental methods of the engineering profession with the biological and medical sciences to achieve a more detailed understanding of biological phenomena and to develop new techniques and devices. The engineers quantitative and analytical approach; traditional competence in the processing and control of information, energy, and materials; and ability to design and analyze systems are powerful tools when applied to biology, medicine; and …
Get the facts about Cal State San Bernardino bioengineering program. Completion of an accredited engineering program can qualify you to enter the workforce as a paid intern immediately.
Find Bioengineering news, conferences, standards, journals, careers and groups from ASME - the center of engineering conversation.
Bioengineering approaches to map mechanotransduction in the living cell Abstract Mechanical forces strongly influence the growth and form of virtually every tis...
Dear Bioengineering Alumni and Friends, I am pleased to take this opportunity to share with you a number of our communitys many accomplishments from our recent history. As we look back at past events and highlights there is much to celebrate; however, I cannot help but look ahead and feel thrilled at the momentum and direction the department. Truly, it will be exciting as we navigate the opportunities and challenges ahead of us. TENURE LINE FACULTY RECRUITMENTS
Information for current and prospective students, research focus areas, faculty directory, and facilities in the Department of Bioengineering at The University of Texas at Arlington
Various microencapsulated insecticide formulations for the control of pests such as aphids and beet army worm. These formulations exhibit excellent knockdown activity towards both chewing and non-chew
In a pioneering first, Duke University Hospital surgeons have implanted a bioengineered vein into a kidney dialysis patient as part of a clinical trial.
Do you enjoy eating meat, but cant bring yourself to contribute to the slaughter of live animals? Dont worry, someday soon youll be able to order some bioengineered meat... Thats right, whether bioprinted or biofabricated (grown on a specially prepared scaffold), it is likely that meat alternatives of the near future will be made of…
In the four hours since our capture on a wooded mountain in Vermont,I had seen my friends variously shot clean through with a crossbow,dismembered by a flying double-bladed ax, sawed in half by duelingchainsaws, impaled and roasted over the fire, and crushed under acoffin-size boulder. Yet we were all still alive.. The latest torture was of my best friend Antonio, who suffereda series of skin grafts and organ replacements from wild animalsincluding bears, wolves, buffaloes, one tortoise, a puma, and an owl,making him into a mottle of a little humanity and a lot of beast. Hewas then sewn into a canvas stretcher and strapped into a framework ofboughs broken from nearby trees. The whole thing was then placed onthe armature of a gigantic catapult. The catapult was cockedand ready to fling him out over the valley.. The robed figure who had captured us held a hatchet in onehand and a whip in the other. By waving his hands and enunciating aseries of spells, he had made the catapult assemble itself ...
Novel tissue engineering approaches are emerging to meet regenerative medicine demands and challenges towards successful therapies to completely restore the function in damaged or degenerated tissues. Among them, magnetic tissue engineering envisions the development of complex systems in which magnetic elements are exploited as remotely controlled multidimensional tools with potential for diagnostic and therapeutic actions. This chapter provides an overview of the latest developments in the design and assessment of magnetic tissue engineering strategies with particular emphasis on smart magnetic materials and their relevance for tissue regeneration. Special attention will be given to the fabrication of sophisticated systems from the nano to the macro scale, and to the role of magnetic smart materials for providing alternative approaches to address the demanding tissue requirements and meet successful alternative strategies for regenerative medicine. The cellular response to the presence of ...
As one of the top bioengineering programs in the region the University of Colorado Denver provides a unique opportunity for students to study engineering while gaining hands on experience in biomedical and clinical sciences.
CSBE/SCGAB Canadian Society for Bioengineering / Société Canadienne de Génie Agroalimentaire et de Bioingénierie. Provides information on and links to agricultural engineering, food engineering and biological engineering.
CSBE/SCGAB Canadian Society for Bioengineering / Société Canadienne de Génie Agroalimentaire et de Bioingénierie. Provides information on and links to agricultural engineering, food engineering and biological engineering.
Information about University of Mary Washington bioengineering program. There are a variety of engineering training programs that may appeal to you, such as mechanics, vehicle design, and alternative energy production.
Find info concerning San Francisco State University bioengineering program. As the entrance requirements for engineering programs vary, learn about the various specialization options available.
A novel bioengineered human skeletal muscle model with accurate physiological and pharmacological responses may provide a useful tool for preclinical testing.
Meet Tissue Engineering, Regenerative Medicine, Stem Cell Professionals at the upcoming Worlds best Tissue Engineering Conferences
(NaturalNews) Even as the veggie blame game is now under way across the EU, where a super resistant strain of e. coli is sickening patients and filling hospitals in Germany, virtually no one is talkin
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Program credit weight: 142-152 credits Program credit weight for Quebec CEGEP students: 122-123 credits Program credit weight for out-of-province students: 142-143 credits The B.Eng.; Major in Bioengineering will 1) provide students with the ability to apply systematic knowledge of biology, physical sciences and mathematics; and sound engineering foundations in order to solve problems of a biological nature; and 2) prepare students for the broad area of bioengineering, incorporating both biology-focused biological engineering and medicine-focused biomedical engineering. Students will acquire fundamental knowledge in bioengineering-related natural sciences and mathematics, as well as in the foundations of general engineering and bioengineering. Students will also acquire knowledge in one area of specialization of bioengineering: 1) biological materials and biomechanics; 2) biomolecular and cellular engineering; or 3) biomedical, diagnostic and high throughput screening engineering.. ...
...New Rochelle NY -- Bioengineering -- the application of engineering p...The issue captures the broad scope of current and future diagnostic an...Original research articles featured in this issue of Journal of Neurot... The Journal is pleased to publish this issue which addresses many of ...,Bioengineering,yields,new,approaches,for,diagnosing,and,treating,traumatic,brain,injury,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Wearable kinematic sensors can be used to study head injury biomechanics based on kinematics and, more recently, based on tissue strain metrics using kinematics-driven brain models. These sensors require in-situ calibration and there is currently no data conveying wearable ability to estimate tissue strain. We simulated head impact (n = 871) to a 50th percentile Hybrid III (H-III) head wearing a hockey helmet instrumented with wearable GForceTracker (GFT) sensors measuring linear acceleration and angular velocity. A GFT was also fixed within the H-III head to establish a lower boundary on systematic errors. We quantified GFT errors relative to H-III measures based on peak kinematics and cumulative strain damage measure (CSDM). The smallest mean errors were 12% (peak resultant linear acceleration) and 15% (peak resultant angular velocity) for the GFT within the H-III. Errors for GFTs on the helmet were on average 54% (peak resultant linear acceleration) and 21% (peak resultant angular velocity). ...
Applying innovative bio-materials to regenerative medicine.. My research interests are linked by the hypothesis that combinatorial approaches to tissue formation are superior to individual stimulation. More specifically, successful tissue engineering approaches will be realised upon the proper spatial and temporal presentation of cells, signaling molecules, biomaterials, and mechanical stimulation. My research team seeks to engineer functional replacement and temporary bridge tissues using a modular approach while also developing model systems to study physiological and pathophysiological corneal tissue formation.. The biotechnology industry is rapidly expanding and the evolving fields of tissue engineering and cell-based therapy are projected to have a high impact in regenerative medicine. In particular my lab is investigating the application of functionalized peptide/polymer water-based gels in these progressively merging fields. Using these jelly-like substances I aim to improve stem cell ...

Microfabrication in Tissue Engineering and Bioartificial Organs | SpringerLinkMicrofabrication in Tissue Engineering and Bioartificial Organs | SpringerLink

Stephen D. Senturia Cambridge MA Microfabrication in Tissue Engineering and Bioartificial Organs Foreword One of the emerging ... applications of microsystems technology in biology and medicine is in the field of tissue engineering and artificial organs. In ...
more infohttps://link.springer.com/book/10.1007/978-1-4615-5235-2

Bioartificial organs and tissues: a euopean patnership in cellular engineering for improved health and industrial...Bioartificial organs and tissues: a euopean patnership in cellular engineering for improved health and industrial...

... proposed programme is to conduct a multi-disciplinary research activity in order to evolve bioartificial tissues and organs, ... Bioartificial organs and tissues: a euopean patnership in cellular engineering for improved health and industrial ... Bioartificial organs and tissues: a euopean patnership in cellular engineering for improved health and industrial ... Bioartificial organs and tissues: a euopean patnership in cellular engineering for improved health and industrial ...
more infohttps://cordis.europa.eu/project/rcn/30890_pl.html

Bio)Artificial OrgansBio)Artificial Organs

The chair of (bio) artificial organs addresses several of these challenges by developing an innovative research program, which ... Bioartificial: combining biomaterials and biological cells to fully replace failing patient organs. Typical examples here are ... This chair has the ambition, to take-on the challenge of helping the patients by developing (bio) artificial organs. These ... The complexity increases from artificial to bioartificial organs, and the engineering and regulatory demands increase further ...
more infohttps://www.utwente.nl/en/tnw/bst/research/section_stamatialis/

Polymers | Free Full-Text | Gelatin-Based Hydrogels for Organ 3D BioprintingPolymers | Free Full-Text | Gelatin-Based Hydrogels for Organ 3D Bioprinting

The main objective of these technologies is to produce high-throughput and/or customized organ substitutes (or bioartificial ... the distinguished potential to eventually manufacture implantable bioartificial organs for purposes such as customized organ ... This article is an overview of the intrinsic/extrinsic properties of the gelatin-based hydrogels in organ 3D bioprinting areas ... Multi-nozzle extrusion-based organ 3D bioprinting technologies have ...
more infohttp://www.mdpi.com/2073-4360/9/9/401

Patent US20090203979 - Implantable sensor electrodes and electronic circuitry - Google PatentsPatent US20090203979 - Implantable sensor electrodes and electronic circuitry - Google Patents

Vascular bioartificial organ. US5593852 *. 1 Sep 1994. 14 Jan 1997. Heller; Adam. Subcutaneous glucose electrode. ...
more infohttp://www.google.ca/patents/US20090203979

March-April 2006 - Volume 52 - Issue 2 : ASAIO JournalMarch-April 2006 - Volume 52 - Issue 2 : ASAIO Journal

ASAIO Journal is the primary source for updates in artificial organ research, development, and testing. In the forefront of the ... THE POSSIBLE MECHANISM OF REDUCED ANTIGENICITY OF THE TRACHEAL BIOARTIFICIAL ORGAN TREATED BY CRYOPRESERVATION. Liu, Yu; Zheng ... NUMERICAL MODELING TO ASSESS OXYGEN AVAILABILITY IN THE AMC BIOARTIFICIAL LIVER. Mareels, Guy; Poyck, Paul P.; Eloot, Sunny; ... CHARACTERIZATION OF A NOVEL PORCINE LIVER SLICE-FILLED BIOARTIFICIAL LIVER (BAL) FOR TREATMENT OF LIVER FAILURE PATIENTS. ...
more infohttps://journals.lww.com/asaiojournal/toc/2006/03000

Ott Laboratory: Harald Ott, MD - Massachusetts General Hospital, Boston, MAOtt Laboratory: Harald Ott, MD - Massachusetts General Hospital, Boston, MA

Bioartificial tissues and organs: are we ready to translate?. Ott HC, Mathisen DJ.. Lancet. 2011 Dec 10;378(9808):1977-8. Epub ... Recellularization of organs: what is the future for solid organ transplantation?. Moser PT, Ott HC. Curr Opin Organ Transplant. ... On the road to bioartificial organs.. Ren X, Ott HC.. Pflugers Arch. 2014 Oct;466(10):1847-57. doi: 10.1007/s00424-014-1504-4. ... Decellularized scaffolds as a platform for bioengineered organs.. Tapias LF, Ott HC.. Curr Opin Organ Transplant. 2014 Apr;19(2 ...
more infohttp://www.massgeneral.org/research/researchlab.aspx?id=1772

Patent US5985164 - Method for forming a filter - Google PatentsPatent US5985164 - Method for forming a filter - Google Patents

Ultrafiltration membrane, device, bioartificial organ, and related methods. US9433573. Jun 1, 2015. Sep 6, 2016. Delpor, Inc.. ... Ultrafiltration membrane, device, bioartificial organ, and methods. US20050072689 *. Mar 6, 2003. Apr 7, 2005. Reimar Spohr. ... Ultrafiltration membrane,device, bioartificial organ, and methods. US20060282115 *. Jun 9, 2005. Dec 14, 2006. Abrams Robert M ... Ultrafiltration membrane device, bioartificial organ, and related methods. US20020119589 *. Jan 24, 2002. Aug 29, 2002. Frank ...
more infohttp://www.google.com/patents/US5985164?dq=Xerox+%2B+%22centroid

Patent US5543046 - Inorganic membrane for microfiltration, and a process for production of such ... - Google PatentsPatent US5543046 - Inorganic membrane for microfiltration, and a process for production of such ... - Google Patents

Ultrafiltration membrane device, bioartificial organ, and related methods. US20020162791 *. Jun 12, 2002. Nov 7, 2002. Baxter ... Ultrafiltration Membrane, Device, Bioartificial Organ, And Related Methods. US20100022945 *. Oct 8, 2009. Jan 28, 2010. Theron ... Ultrafiltration membrane, device, bioartificial organ, and related methods. US9597642. Jul 23, 2014. Mar 21, 2017. Lg Nanoh2O, ... Ultrafiltration membrane, device, bioartificial organ, and methods. US20040250683 *. Apr 28, 2004. Dec 16, 2004. Innovative ...
more infohttp://www.google.com/patents/US5543046?dq=6,757,710

Online- and offline- monitoring of stem cell expansion on microcarrier | SpringerLinkOnline- and offline- monitoring of stem cell expansion on microcarrier | SpringerLink

Int J Bioartificial Organs 33:512-525Google Scholar. *. Weber C, Pohl S, Poertner R, Pino-Grace P, Wallrapp C, Geigle P, ...
more infohttps://link.springer.com/article/10.1007%2Fs10616-011-9359-4

IJMS | Free Full-Text | Differential Impact of Hyperglycemia in Critically Ill Patients: Significance in Acute Myocardial...IJMS | Free Full-Text | Differential Impact of Hyperglycemia in Critically Ill Patients: Significance in Acute Myocardial...

New Phase of Growth for Xenogeneic-Based Bioartificial Organs. Next Article in Special Issue. Extracts of Magnolia Species- ...
more infohttp://www.mdpi.com/1422-0067/17/9/1586

Experimental Biology - Preliminary ProgramExperimental Biology - Preliminary Program

Bioartificial Organs: Using Donor and Synthetic Scaffolds. *Biosensors in Health and Disease ... Building Epithelial Organs in vitro to Study Physiology and Pathogenesis of Disease ... Building Epithelial Organs in vitro to Study Physiology and Pathogenesis of Disease ... Building Epithelial Organs in vitro to Study Physiology and Pathogenesis of Disease ...
more infohttp://experimentalbiology.org/2018/Program/Preliminary-Program.aspx

Saving Lives with Living Machines - MIT Technology ReviewSaving Lives with Living Machines - MIT Technology Review

But what of the hundreds of thousands of patients with chronically diseased organs? Bioartificial-organ technology could ... Bioartificial organs most compelling use may be for kidney failure patients. While a strictly artificial device such as a ... While bioartificial organs offer benefits that purely mechanical devices cant match, they still have some severe limitations. ... As Paganini puts it, "The concept of a bioartificial organ is in and of itself exciting." But whats even more exciting to ...
more infohttps://www.technologyreview.com/s/402031/saving-lives-with-living-machines/

Center for Surgery, Innovation & Bioengineering - Massachusetts General Hospital, Boston, MACenter for Surgery, Innovation & Bioengineering - Massachusetts General Hospital, Boston, MA

Investigating whole-organ tissue engineering of bioartificial organs for transplantation. *Exploring new preservation ... Uygun BE, Yarmush ML, Uygun K. Application of whole-organ tissue engineering in hepatology. Nat Rev Gastroenterol Hepatol. 2012 ... Developing new studies that challenge the current dogma regarding the underlying mechanisms of multi-system organ failure in ... The center focuses on artificial organ development, biopreservation, metabolic engineering, stem cell bioengineering, ...
more infohttps://www.massgeneral.org/surgery/research/researchlab.aspx?id=1615&display=projects

New technologies provide more metabolic engineering strategies for bioethanol production in Zymomonas mobilis.New technologies provide more metabolic engineering strategies for bioethanol production in Zymomonas mobilis.

... and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.. National Institute Of Biomedical Imaging And Bioengineering (u.s ... for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives. ... or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2265527/New-technologies-provide-more-metabolic-engineering-strategies-for-bioethanol-production-in-Zymomonas.html

September 2010 - Fight Aging!September 2010 - Fight Aging!

So to the future of bioartificial organs. A computer doesnt look much like a brain, a slide-rule, or a typewriter. The ... The future of our organs is as much artificial as it is fleshy. In the competition to develop a source of replacement organs ... Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to ... Researchers are keenly interested in stem cells because they typically morph into the organs where they are transplanted. But ...
more infohttps://www.fightaging.org/archives/2010/09/

Global Bio-implants Market Report - Stratistics Market Research ConsultingGlobal Bio-implants Market Report - Stratistics Market Research Consulting

o Bioartificial organs. o Cell therapy. o Tissue engineering. • Biologised implants. o Biohybrid systems. o Technical implants ...
more infohttp://www.mynewsdesk.com/us/pressreleases/global-bio-implants-market-report-1746459

Bio-Implants Market Research Report, Forecast to 2017: MarketsandMarketsBio-Implants Market Research Report, Forecast to 2017: MarketsandMarkets

Biological implants (cell therapy, bioartificial organs and tissue engineering) *Biologised implants (technical implants, ... as well as soft tissues including organs, and skin. Over the century, these have evolved and are now used for not just ...
more infohttps://www.marketsandmarkets.com/Market-Reports/bio-implants-market-728.html

Doris A. Taylor, PhD, Hon DSc:  Director, Regenerative Medic... : TransplantationDoris A. Taylor, PhD, Hon DSc: Director, Regenerative Medic... : Transplantation

Is the aging process of Extracellular Matrix (ECM, as the structure of bioartificial organs) comparable to that of cells that ... Less complex organs, such as bladder (a balloon) and trachea (a tube), have been constructed in the laboratory. Whole organ ... In this case, we opened the door to autologous solid organ transplant-or to building biologic organs in the laboratory. ... or organ patches appear feasible applications. What modality do you see clinically most relevant and applicable?. DAT: Organ ...
more infohttps://journals.lww.com/transplantjournal/Fulltext/2018/12000/Doris_A__Taylor,_PhD,_Hon_DSc___Director,.4.aspx

US20020173453A1 - Method of treating renal injury 
        - Google PatentsUS20020173453A1 - Method of treating renal injury - Google Patents

Organ Technologies Inc.. Process for production of bioartificial organ ES2552668T3 (en) * 2010-06-28. 2015-12-01. Bbs - ... Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized ... transplants are limited by the availability of donor organs, the operative risks associated with major surgery, and the post- ...
more infohttps://patents.google.com/patent/US20020173453?oq=821%2C393

Biomaterials Science and Technology - Activities
     - University of Twente Research InformationBiomaterials Science and Technology - Activities - University of Twente Research Information

Bio)artificial organs to mimic and / or replace patient failing organs. D. Stamatialis (Speaker). 12 Feb 2018 ... New membrane concepts for (bio)artificial organs and regenerative medicine. D. Stamatialis (Speaker). 5 Jun 2018 → 7 Jun 2018 ... Membranes for (bio)artificial organs and regenerative medicine. D. Stamatialis (Speaker). 29 Jun 2018 ... Bioartificial kidney, new developments. D. Stamatialis (Speaker). 7 Dec 2018 → 9 Dec 2018 ...
more infohttps://research.utwente.nl/en/organisations/biomaterials-science-and-technology/activities/

Scientists create replacement organs using bodys own cells | ZDNetScientists create replacement organs using body's own cells | ZDNet

... to create them a new organ using their own cells. ... beginning to come up with a way to help patients who need organ ... Scientists are having preliminary success with a new way to get patients new organs that they may need: bioartificial organs ... One of the problems of organ transplants is the potential for the body to reject the foreign organ. For this reason, organ ... After all the cells were gone (in three days), what was left of the organs was the scaffold, the basic shape of the organ, ...
more infohttps://www.zdnet.com/article/scientists-create-replacement-organs-using-bodys-own-cells/

US6107055A - Method and device for carrying out biochemical reactions 
        - Google PatentsUS6107055A - Method and device for carrying out biochemical reactions - Google Patents

Ultrafiltration membrane, device, bioartificial organ, and methods US6012902A (en) 2000-01-11. Micropump ...
more infohttps://patents.google.com/patent/US6107055A/en

tissue repair - meddictissue repair - meddic

Bioartificial Organs[edit]. An article printed in the New York Times "A First: Organs Tailor-Made With Bodys Own Cells," it ... Bioartificial Windpipe : The first procedure of regenerative medicine of an implantation of a "bioartificial" organ. ... Doctors grow organs from patients own cells, CNN, 3 April 2006. *^ Lab-grown cartilage fixes damaged knees - health - 5 July ... Recent research on organ printing is showing how crucial a good control of the 3D environment is to ensure reproducibility of ...
more infohttp://meddic.jp/tissue_repair
  • So far, only a few such organs have been created and transplanted, and the they aren't complex organs -- just simples one like bladders and a windpipe. (zdnet.com)
  • These mechanical fields have accounted well for the observed orientation of MFB axes in healing wounds in the two organs as well as the eventual orientation of collagen fibers both in dermal scar (planar orientation) and neural scar (circumferential orientation). (mit.edu)
  • The first step in the organ bioengineering process is decellularization of cadaver hearts using detergents such as sodium dodecyl sulfate, leaving a collagen framework. (wikipedia.org)
  • Living membranes' of renal epithelial cells on biofunctionalized membranes (the 'bioartificial kidney' (BAK)) have been shown to improve the removal of protein-bound toxin, representing a great leap forward for dialysis patients. (utwente.nl)
  • Even such temporary support could be a boon for medicine, sustaining thousands of patients and enabling them to regain the function of their own organs or survive until transplant organs become available. (technologyreview.com)
  • Induced pluripotent stem cells or progenitor cells generated from a patient's skin, blood, bone marrow or other sources will then be used in an attempt to repopulate the organ and to form a fully functioning human heart without risk of rejection. (wikipedia.org)
  • Herein, an overview of the current literature for kidney decellularization and whole-organ recellularization is presented, addressing the pros and cons of the actual techniques already developed, the methods adopted to evaluate the efficacy of the procedures, and the challenges to be overcome in order to achieve an optimal protocol. (frontiersin.org)
  • The main objective of these technologies is to produce high-throughput and/or customized organ substitutes (or bioartificial organs) with heterogeneous cell types or stem cells along with other biomaterials that are able to repair, replace or restore the defect/failure counterparts. (mdpi.com)
  • This project draws from expertise in stem cell biology, developmental biology, physiology, cardiology, and biomedical engineering in pursuit of creating a bioartificial heart as an alternative treatment option for patients in need of heart transplants. (massgeneral.org)
  • Three-dimensional (3D) bioprinting is a family of enabling technologies that can be used to manufacture human organs with predefined hierarchical structures, material constituents and physiological functions. (mdpi.com)
  • Scientists are beginning to come up with a way to help patients who need organ transplants: to create them a new organ using their own cells. (zdnet.com)
  • A detergent-like liquid connected via tube dripped into the jar and out, slowly stripping the organs of their living cells. (zdnet.com)
  • After all the cells were gone (in three days), what was left of the organs was the scaffold, the basic shape of the organ, composed of a matrix of proteins and other compounds that keep the right cells in the right places. (zdnet.com)
  • For this reason, organ donor recipients have to take drugs that suppress the immune system. (zdnet.com)
  • Such devices are years from fruition, but Humes and other researchers developing living temporary devices have started laying the groundwork for them-with the potential for eventually saving hundreds of thousands of lives ( see Bioartificial Potential ). (technologyreview.com)
  • One of the problems of organ transplants is the potential for the body to reject the foreign organ. (zdnet.com)
  • Scientists are looking to nature to guidance on how to create these bioartificial organs. (zdnet.com)
  • TLM has replaced open laryngeal surgery for managing early glottic cancer, while preserving organ and function. (enttoday.org)
  • While bioartificial organs offer benefits that purely mechanical devices can't match, they still have some severe limitations. (technologyreview.com)
  • Study of the wound healing process in skin and peripheral nerves by the Yannas group showed that both organs healed by contraction and scar formation. (mit.edu)
  • Gelatin-based hydrogels, such as gelatin/fibrinogen, gelatin/hyaluronan and gelatin/alginate/fibrinogen, have unique features in organ 3D bioprinting technologies. (mdpi.com)
  • This article is an overview of the intrinsic/extrinsic properties of the gelatin-based hydrogels in organ 3D bioprinting areas with advanced technologies, theories and principles. (mdpi.com)