Biliary Tract Neoplasms: Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Biliary Tract Diseases: Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Biliary Tract: The BILE DUCTS and the GALLBLADDER.Biliary Tract Surgical Procedures: Any surgical procedure performed on the biliary tract.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Cholangiocarcinoma: A malignant tumor arising from the epithelium of the BILE DUCTS.Gallstones: Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.Bile Ducts, Extrahepatic: Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Cholelithiasis: Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).Bile Ducts, Intrahepatic: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.Cholangitis: Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.Gallbladder: A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.Cholecystectomy: Surgical removal of the GALLBLADDER.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Bile Ducts: The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.Choledochostomy: Surgical formation of an opening (stoma) into the COMMON BILE DUCT for drainage or for direct communication with a site in the small intestine, primarily the DUODENUM or JEJUNUM.Bile: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.Common Bile Duct: The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.Cholecystitis: Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).Biliary Fistula: Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.Cholangiopancreatography, Endoscopic Retrograde: Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.Cholangiography: An imaging test of the BILIARY TRACT in which a contrast dye (RADIOPAQUE MEDIA) is injected into the BILE DUCT and x-ray pictures are taken.Bile Duct Diseases: Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.Cholestasis, Extrahepatic: Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.Hepatic Duct, Common: Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.Choledochal Cyst: A congenital anatomic malformation of a bile duct, including cystic dilatation of the extrahepatic bile duct or the large intrahepatic bile duct. Classification is based on the site and type of dilatation. Type I is most common.DeoxycytidineGallbladder Diseases: Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.CA-19-9 Antigen: Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.Mammaglobin B: A MAMMAGLOBIN A-related secretoglobin that is expressed in several HUMAN tissues including the UTERUS; BREAST; SALIVARY GLAND; and LACRIMAL GLAND.Jejunostomy: Surgical formation of an opening through the ABDOMINAL WALL into the JEJUNUM, usually for enteral hyperalimentation.Common Bile Duct Diseases: Diseases of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Pancreatic Diseases: Pathological processes of the PANCREAS.Drainage: The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.Gastrointestinal Tract: Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).Cystic Duct: The duct that is connected to the GALLBLADDER and allows the emptying of bile into the COMMON BILE DUCT.Urinary Tract: The duct which coveys URINE from the pelvis of the KIDNEY through the URETERS, BLADDER, and URETHRA.Imino AcidsCholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.China: A country spanning from central Asia to the Pacific Ocean.Tegafur: Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Cholangiopancreatography, Magnetic Resonance: Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Pyramidal Tracts: Fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts.Sphincterotomy, Endoscopic: Incision of Oddi's sphincter or Vater's ampulla performed by inserting a sphincterotome through an endoscope (DUODENOSCOPE) often following retrograde cholangiography (CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE). Endoscopic treatment by sphincterotomy is the preferred method of treatment for patients with retained or recurrent bile duct stones post-cholecystectomy, and for poor-surgical-risk patients that have the gallbladder still present.Liver Diseases: Pathological processes of the LIVER.Hemobilia: Hemorrhage in or through the BILIARY TRACT due to trauma, inflammation, CHOLELITHIASIS, vascular disease, or neoplasms.Oxonic Acid: Antagonist of urate oxidase.Iatrogenic Disease: Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.Sphincter of Oddi: The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.Choledocholithiasis: Presence or formation of GALLSTONES in the COMMON BILE DUCT.Polydioxanone: An absorbable suture material used also as ligating clips, as pins for internal fixation of broken bones, and as ligament reinforcement for surgically managed ligament injuries. Its promising characteristics are elasticity, complete biodegradability, and lack of side effects such as infections.Technetium Tc 99m Lidofenin: A nontoxic radiopharmaceutical that is used in RADIONUCLIDE IMAGING for the clinical evaluation of hepatobiliary disorders in humans.Anastomosis, Roux-en-Y: A Y-shaped surgical anastomosis of any part of the digestive system which includes the small intestine as the eventual drainage site.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Liver Neoplasms: Tumors or cancer of the LIVER.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Jaundice, Obstructive: Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.Hepatic Artery: A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.Catgut: Sterile collagen strands obtained from healthy mammals. They are used as absorbable surgical ligatures and are frequently impregnated with chromium or silver for increased strength. They tend to cause tissue reaction.Cholecystectomy, Laparoscopic: Excision of the gallbladder through an abdominal incision using a laparoscope.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Lithiasis: A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).Biliary Dyskinesia: A motility disorder characterized by biliary COLIC, absence of GALLSTONES, and an abnormal GALLBLADDER ejection fraction. It is caused by gallbladder dyskinesia and/or SPHINCTER OF ODDI DYSFUNCTION.Liver Abscess: Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.Endoscopy, Digestive System: Endoscopic examination, therapy or surgery of the digestive tract.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Secretoglobins: A structurally-related family of small, multimeric proteins that are secreted in the mucosa of mammalian epithelial tissues. A variety of proteins are classed under this heading including some secretoglobin subtypes that appear unique to a particular mammalian species, and others whose functions differ between species.Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Fistula: Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.Vomiting, Anticipatory: Vomiting caused by expectation of discomfort or unpleasantness.Claudin-4: A claudin subtype that takes part in maintaining the barrier-forming property of TIGHT JUNCTIONS. Claudin-4 is found associated with CLAUDIN-8 in the KIDNEY COLLECTING DUCT where it may play a role in paracellular chloride ion reabsorption.Time Factors: Elements of limited time intervals, contributing to particular results or situations.TokyoSphincterotomy, Transhepatic: Surgery of the smooth muscle sphincter of the hepatopancreatic ampulla to relieve blocked biliary or pancreatic ducts.Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.Cholecystitis, Acute: Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.Ultrasonography: The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Acute Disease: Disease having a short and relatively severe course.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Fluoroimmunoassay: The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.Biliary Atresia: Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.Pancreatic Juice: The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.Fasciola hepatica: A species of helminth commonly called the sheep liver fluke. It occurs in the biliary passages, liver, and gallbladder during various stages of development. Snails and aquatic vegetation are the intermediate hosts. Occasionally seen in man, it is most common in sheep and cattle.Cyclin H: A cyclin subtype that is found as a component of a heterotrimeric complex containing cyclin-dependent kinase 7 and CDK-activating kinase assembly factor. The complex plays a role in cellular proliferation by phosphorylating several CYCLIN DEPENDENT KINASES at specific regulatory threonine sites.UracilDilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Bilirubin: A bile pigment that is a degradation product of HEME.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

New perspectives on biliary atresia. (1/473)

An investigation into the aetiology, diagnosis, and treatment of biliary atresia was carried out because the prognosis remains so poor.In an electron microscopical study no viral particles or viral inclusion bodies were seen, nor were any specific ultrastructural features observed. An animal experiment suggested that obstruction within the biliary tract of newborn rabbits could be produced by maternal intravenous injection of the bile acid lithocholic acid.A simple and atraumatic method of diagnosis was developed using(99) (m)Tc-labelled compounds which are excreted into bile. Two compounds, (99m)Tc-pyridoxylidene glutamate ((99m)Tc-PG) and (99m)Tc-dihydrothioctic acid ((99m)Tc-DHT) were first assessed in normal piglets and piglets with complete biliary obstruction. Intestinal imaging correlated with biliary tract patency, and the same correlation was found in jaundiced human adults, in whom the (99m)Tc-PG scan correctly determined biliary patency in 21 out of 24 cases. The (99m)Tc-PG scan compared well with liver biopsy and (131)I-Rose Bengal in the diagnosis of 11 infants with prolonged jaundice.A model of extrahepatic biliary atresia was developed in the newborn piglet so that different methods of bile drainage could be assessed. Priorities in biliary atresia lie in a better understanding of the aetiology and early diagnosis rather than in devising new bile drainage procedures.  (+info)

Casts of hepatic blood vessels: a comparison of the microcirculation of the penguin, Pygoscelis adeliae, with some common laboratory animals. (2/473)

Latex casts of the hepatic blood vessels of the penguin, Pygoscelis adeliae, and of some common laboratory animals were compared. There was general similarity between the different species, but the portal venous and hepatic arterial systems of the penguin were simpler than those of other species. Measurements were made of the volume and length of portal veins and it appears that the portal venous system is capable of being a more efficient blood reservoir in the penguin than in other species studied. The peribiliary plexus was especially well formed in the penguin and was drained by long veins which usually joined portal venous branches. Some of the long veins drained directly into the hepatic venous tree: these translobular veins were more prominent than in mammals. Anastomoses between hepatic artery and portal vein were not present in penguins, and the supply to the sinusoids appeared to be separate. The morphology of small hepatic veins of all the species appeared to be similar.  (+info)

Metabolism and disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) in rhesus monkeys. (3/473)

Metabolism and disposition of the tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent rodent lung carcinogen, were studied in rhesus monkeys. In three males receiving a single i.v. dose of [5-3H]NNK (0.72 mCi; 4.6-9.8 microg/kg), urine was collected for 10 days. Within the first 24 h, 86.0 +/- 0.7% of the dose was excreted. NNK-derived radioactivity was still detectable in urine 10 days after dosing (total excretion, 92.7 +/- 0.7%). Decay of urinary radioactivity was biexponential with half-lives of 1.7 and 42 h. Metabolite patterns in urine from the first 6 h closely resembled those reported previously for patas monkeys; end products of metabolic NNK activation represented more than 50% of total radioactivity. At later time points, the pattern shifted in favor of NNK detoxification products (60-70% of total radioactivity in urine), mainly 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its O-glucuronide conjugates. One female rhesus monkey received a single i.v. dose of [5-3H]NNK (1.72 mCi; 28.4 microg/kg) under isoflurane anesthesia; biliary excretion over 6 h (0.6% of the dose) was 10 times less than predicted by our previously reported rat model. No preferential excretion of NNAL glucuronide was observed in monkey bile. Collectively, these results suggest that the rhesus monkey could be a useful model for NNK metabolism and disposition in humans.  (+info)

Review article: antibiotic prophylaxis for endoscopic retrograde cholangiopancreatography (ERCP). (4/473)

This review examines the evidence for antibiotic prophylaxis in endoscopic retrograde cholangiopan-creatography (ERCP), and provides detailed advice about suitable antibiotic regimens in appropriate high-risk patients. Ascending cholangitis and infective endocarditis are potential complications of endoscopic ERCP. The pathophysiology of these two complications is quite separate and different sub-groups of patients require prophylaxis with appropriate antibiotic regimens. Ascending cholangitis results from bacterial infection of an obstructed biliary system, usually from enteric Gram-negative microorganisms, resulting in bacteraemia. There is incomplete drainage of the biliary system after ERCP in up to 10% of patients who require stenting. Antibiotics started in these patients will probably reduce the frequency of cholangitis by 80%. If antibiotics are restricted to this group, approximately 90% of all patients having an ERCP will avoid antibiotics, but 80% of cholangitic episodes will be prevented. Infective endocarditis may result from the bacteraemia caused at the time of the ERCP in patients with an abnormal heart valve. Antibiotic prophylaxis, in particular covering alpha-haemolytic streptococci, should be started before the procedure in this defined high-risk group.  (+info)

Enterogastric reflux mimicking gallbladder disease: detection, quantitation and potential significance. (5/473)

OBJECTIVE: Visualization of enterogastric reflux (EGR) may be present during hepatobiliary imaging. Reflux of bile may damage the gastric mucosa, altering its function, and cause such symptoms as epigastric pain, heartburn, nausea, intermittent vomiting and abdominal fullness. These symptoms also are associated with gallbladder disease. The aim of this study was to quantitate the EGR index (EGRI) and to determine if a difference exists in normal and abnormal responses using standard cholecystokinin (CCK)-augmented hepatobiliary imaging. METHODS: This study used 129 patients. LAO dynamic data on a 128 x 128 matrix at a rate of 1 frame/min were obtained. After the gallbladder ejection fraction (GBEF) was determined, the EGRI (%) was calculated by relating the counts in the gastric ROI to the counts in the hepatobiliary ROI at a specified time. The results were compared with the patient's final clinical diagnosis. RESULTS: Normal responders (GBEF > or = 35%) had a higher EGRI than abnormal responders with a P = 0.001 EGR observed in 75 patients (58.1%). Significant reflux (EGRI > or = 14.2% at 15 min) was observed in 29 additional patients (22.5%). Patients with EGRI > or = 24.5% showed a strong association with the pathophysiologic syndrome of gastritis, alkaline reflux, gastric ulcer and gastro esophageal reflux disease. There was no EGR observed in the remaining 25 patients (19.4%). CONCLUSION: This simple addition to the CCK-augmented hepatobiliary imaging may both detect and quantitate abnormal EGR as the cause of the patient's symptoms in the presence of a normal GBEF result, and/or those patients with risk factors for gastritis.  (+info)

The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids. (6/473)

Class III P-glycoproteins (Pgps) mediate biliary phosphatidylcholine (PC) secretion. Recent findings that class I P-glycoproteins are able to transport several short-chain phospholipid analogues raises questions about the role of these Pgps in physiological lipid transport. We investigated the biliary secretion of C6-7-nitro-2,1, 3-benzoxadiazol-4-yl (NBD)-labeled ceramide and its metabolites in Mdr1a/b and Mdr2 knockout mice compared to control mice. Biliary secretion of these NBD-lipids was unaffected in Mdr1a/b -/- mice. Thus neither Mdr1a nor Mdr1b Pgp mediates biliary secretion of these lipids. In contrast, secretion of all three NBD-labeled short-chain phospholipids was significantly reduced in Mdr2 -/- mice. As in vitro studies revealed that Mdr2 Pgp is not able to translocate these lipid analogues, we hypothesized that Mdr2 -/- mice had a reduced PC content of the exoplasmic canalicular membrane leaflet so that extraction of the short-chain lipid probes from this membrane by canalicular bile salts was impaired. To investigate this possibility we studied the bile salt-mediated extraction of natural sphingomyelin (SM) and NBD-labeled short-chain SM from small unilamellar vesicles of different lipid composition. Natural SM could be extracted by the bile salt tauroursodeoxycholate from vesicles containing PC, cholesterol (CHOL), and SM (1:2:2) but not from vesicles containing only SM and CHOL (3:2). NBD-labeled short-chain SM could be extracted from vesicles containing PC while its extraction from pure SM:CHOL vesicles was reduced by 65%. These data confirm that the efficiency of NBD-SM extraction depends on the lipid composition and suggest that the canalicular membrane outer leaflet of Mdr2 -/- mice has a reduced PC content.  (+info)

Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle. (7/473)

Elevated cholesterol decreases agonist-induced contractility and enhances stone formation in the gallbladder. The current study was conducted to determine if and how the electrical properties and ionic conductances of gallbladder smooth muscle are altered by elevated cholesterol. Cholesterol was delivered as a complex with cyclodextrin, and effects were evaluated with intracellular recordings from intact gallbladder and whole cell patch-clamp recordings from isolated cells. Cholesterol significantly attenuated the spontaneous action potentials of intact tissue. Furthermore, calcium-dependent action potentials and calcium currents were reduced in the intact tissue and in isolated cells, respectively. However, neither membrane potential hyperpolarizations induced by the ATP-sensitive potassium channel opener, pinacidil, nor voltage-activated outward potassium currents were affected by cholesterol. Hyperpolarizations elicited by calcitonin gene-related peptide were reduced by cholesterol enrichment, indicating potential changes in receptor ligand binding and/or second messenger interactions. These data indicate that excess cholesterol can contribute to gallbladder stasis by affecting calcium channel activity, whereas potassium channels remained unaffected. In addition, cholesterol enrichment may also modulate receptor ligand behavior and/or second messenger interactions.  (+info)

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats. (8/473)

In rats and mice, 1-nitronaphthalene (1-NN) produces both lung and liver toxicity. Even though these toxicities have been reported, the metabolism and disposition of 1-NN have not been elucidated. Therefore, studies were performed to characterize its fate after i.p. and i.v. administration to male Sprague-Dawley rats. After i.p. administration of [(14)C]1-NN (100 mg/kg; 60 microCi/kg), 84% of the dose was eliminated in the urine and feces by 48 h. At 96 h, 60% of the dose was recovered in the urine, 32% in the feces, and 1% collectively in the tissues, blood, and gastrointestinal contents. The terminal phase rate constant (k(term)) of 1-NN was 0.21 h(-1), the terminal phase half-life (T(1/2,term)) was 3.40 h, and the systemic bioavailability was 0.67. When administered i.v. (10 mg/kg; 120 microCi/kg), 85% of the dose was eliminated in the urine and feces by 24 h. At the end of the study (96 h), 56% of the dose was recovered in the urine, 36% in the feces, and 1% collectively in the tissues, blood, and gastrointestinal contents. Interestingly, 88% of the dose was secreted into bile by 8 h. The k(term) was 0.94 h(-1) and the T(1/2,term) was 0.77 h. The major urinary metabolite after both routes of administration was N-acetyl-S-(hydroxy-1-nitro-dihydronaphthalene)-L-cysteine. Other urinary metabolites identified include hydroxylated, dihydroxylated, glucuronidated, sulfated, and reduced metabolites, as well as dihydrodiol. The major biliary metabolite was hydroxy-glutathionyl-1-nitro-dihydronaphthalene. These data show that 1-NN undergoes extensive metabolism and enterohepatic recirculation, and the majority of the dose is eliminated in the urine.  (+info)

Recent advances in imaging techniques have determined a radical change in the radiological approach to the diagnosis and treatment of hepatobiliary, pancreatic, and.Diagnostic imaging of the hepatobiliary system in infants and children.Diagnostic Imaging of the Hepatobiliary System An Update Angela J.Applied hepatobiliary scintigraphy in. multiple imaging tests are used in what often. while displaying the least activity outside the hepatobiliary system.Gastrointestinal and Hepatobiliary Imaging PIONEERS OF AIIMS-MAMC-PGI IMAGING COURSE SERIES Manorama Berry Sudha Suri.. Imaging is a big part of the workup for evaluating liver cancer ...
Looking for biliary system? Find out information about biliary system. The complex of canaliculi, or microscopic bile ducts, that empty into the larger intrahepatic bile ducts Explanation of biliary system
Others檢查 健康生活易與Mobile Medical Group「MM+」合作提供MM+ Standard Health Check (focus on Hepatobiliary System),詳情 MM+ provides one-stop comprehensive  and quality medical services. We offer a patient-centric healthcare journey with comprehensive, high-quality, caring services. Our centre offers an exclusive VIP waiting room for VIP customers who prefer more privacy. It also provides an area for clients to enjoy snacks or drinks after their check-up.   This standard plan includes standard items that a body health check should have, but focus heavily on screening the health condition of the organ HEPATOBILIARY SYSTEM.
note that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ...
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However, some doctors may want to have incorporation of the pharmacogenomic data into the EMR. This would be quite handy. Using me as an example, if I ever get depression, I would let the doctor know the SSRIs above and the fact that I may, with these meds, require more of the usual dose and sooner. Additionally, I can see there the health maintenance reminder for a patient with LYNCH SYNDROME, for instance would be important. Individuals with Lynch syndrome have an increased risk of colorectal and endometrial cancer [1]. Other sites of cancer include the ovary, stomach, small bowel, hepatobiliary system, renal pelvis, ureter, brain, and skin. There may also be an increased risk of breast, prostate, and pancreatic cancer in individuals with Lynch syndrome. Just using the colorectal cancer screening recommendations (UpToDate): Individuals with Lynch syndrome should undergo colorectal cancer (CRC) screening with colonoscopy every one to two years beginning at age 20 to 25 years, or two to five ...
n of your full length CFTR cDNA. To investigate if any portion of the CFTR cDNA was being unintentionally expressed as a result of the presence of a cryptic
Large search returns make our pages slow to load. Therefore, some functionality has been disabled until you refine your search to bring the number of returned assay results under TBD ...
Mycophenolic acid (MPA) is part of the immunosuppressant therapy for transplant recipients. This study examines the role of the canalicular transporter, Mrp2, and the effect of cyclosporin A (CsA), on the biliary secretion of the ether (MPAGe) and acyl (MPAGa) glucuronides of MPA. Isolated livers from Wistar rats (n = 6), or Wistar TR- rats (n = 6) were perfused with MPA (5 mg/l). A third group of Wistar rats (n = 6) was perfused with MPA and CsA (250 μg/l). There was no difference in the half-life, hepatic extraction ratio (EH), clearance or partial clearance of MPA to MPAGe, but there was a difference in partial clearance to MPAGa between control and CsA groups (0.9 ± 0.4 versus 0.5 ± 0.1 ml/min). TR- rats had a lower EH (0.59 ± 0.30 versus 0.95 ± 0.30), a lower clearance (18 ± 8 versus 29 ± 7 ml/min), and a longer half-life (19.5 ± 10.3 versus 10.1 ± 2.4 min) than controls. Compared to controls, MPAGe and MPAGa biliary excretion was reduced by 99% and 71.8%, respectively, in TR- ...
Rapid and extensive biliary excretion of [d-penicillamine2,5]enkephalin (DPDPE) in rats as the unchanged peptide suggests that multiple transport proteins may be involved in the hepatobiliary disposition of this zwitterionic peptide. Although DPDPE is a P-glycoprotein substrate, the role of other transport proteins in the hepatic clearance of DPDPE has not been established. Furthermore, the ability of various experimental approaches to quantitate the contribution of a specific hepatic uptake or excretion process when multiple transport systems are involved has not been addressed. 3H-DPDPE uptake in suspended Wistar rat hepatocytes was primarily (,95%) due to temperature-dependent transport mechanisms; similar results were obtained in suspended hepatocytes from Mrp2-deficient (TR-) rats. Pharmacokinetic modeling revealed that saturable and linear processes were involved in 3H-DPDPE uptake in hepatocytes. The use of transport modulators suggested that hepatic uptake of 3H-DPDPE was mediated by ...
Ebook `Diseases of the liver, gall bladder, and biliary system; their pathology, diagnosis, and surgical treatment`: ebooks list of Holburt Jacob Waring
Fenestra® VC is a refined version of Fenestra® LC in which the surface of the lipid emulsion particles is modified so as to alter the recognition of the particle by the receptors on hepatocytes that are responsible for its uptake into the liver. With Fenestra VC, the delayed uptake by liver cells produces an agent with superior blood pool imaging properties that last for several hours after injection. Moreover, the agent remains truly intravascular so long as the endothelial integrity of the vessel is maintained. Like its liver-selective counterpart, Fenestra VC is eventually metabolized and eliminated through the hepatobiliary system.. Because of their comparatively long and stable in vivo residence times (up to several hours), the Fenestra® products have shown considerable promise for use in microCT imaging procedures. The numerous benefits provided by the Fenestra technology will play an instrumental role in facilitating the implementation of microCT imaging as an increasingly important ...
The Institutes of Gastroenterology are dedicated to the management of diseases of the digestive and hepatobiliary systems in children and adults. The Institutes offer expert care in both Medical and Surgical Gastroenterology.
Surgery of the liver, pancreas and biliary system HPB stands for Hepato-Pancreato-Biliary surgery. Gallstones and gallbladder surgery.
Posts Tagged With And Biliary System varian cyst symptom checkerh4 other hand if the sphincter of Oddi is a digestion bloating IBS
C.O. Mills, R.G.P. Watson, S. Chandler, J. Trifunovic, E. Elias; Assessment of 123I-Cholylglycyltyrosine and 99MTC-Iodida as Hepatobiliary Imaging Agents in Jaundiced Patients. Clin Sci (Lond) 1 January 1988; 75 (s19): 8P-9P. doi: https://doi.org/10.1042/cs075008Pc. Download citation file:. ...
ERCP and PTHC allow for direct imaging of the biliary ducts. MRCP is a non-invasive alternative for imaging the biliary system ...
A team of specialist doctors from London provides patients and their carers with information about surgery of the liver, pancreas and biliary system that may help them understand their illness better and make the correct decisions. ...
Surgeons at the Burlingame Center offer expertise in the treatment of benign & malignant diseases of the liver, biliary system, & pancreas.
Clay-colored stools or pale stools once may be nothing, but seeing them often can be a sign of a problem in the biliary system. What should you do?
The biliary tract refers to the path by which bile is secreted by the liver then transported to the duodenum, the first part of the small intestine. A structure common to most members of the mammal family, the biliary tract is often referred to as a tree because it begins with many small branches which end in the common bile duct, sometimes referred to as the trunk of the biliary tree. The duct, the branches of the hepatic artery, and the portal vein form the central axis of the portal triad. Bile flows in the direction opposite to that of the blood present in the other two channels. The system is usually referred to as the biliary tract or system, [2]and can include the use of the term "hepatobiliary" when used to refer just to the liver and bile ducts.[3] The name biliary tract is used to refer to all of the ducts, structures and organs involved in the production, storage and secretion of bile.[4] The tract is as follows: ...
Journal: EJNMMI Research ArticleTitle: Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients
Damage of the biliary tract at the end of a period of hepatic preservation prior to liver transplantation has been observed in man. This damage may be important in the development of early biliary complications. A model of hepatic biliary ischaemia in the pig has been developed which permits comparison between the influences of warm and cold ischaemic damage on the biliary tract. The major damage to the biliary tract in the pig in this model appears to occur after prolonged cold preservation.
The molecular pathogenesis of biliary tract cancers is poorly understood. By performing immunohistochemical analysis of more than 125 surgically resected cases of biliary tract carcinoma, we have previously shown altered cell cycle regulatory protein expression in biliary tact cancers [13]. Our current findings also show mutated expression of a large number of cell cycle regulators including UBD, BCL2L2, CDC2, MCM2, and CDKN1C in all subtypes. Similarly, Kang et al. [15] found that expression of G1-S modulators were commonly mutated in 42 cases of IHC. Total loss of p16, p27, and Rb were detected at rates of in 36%, 31%, 12%, respectively, in cancer specimens. Furthermore, in the above study, even in 7 of 13 cases of biliary dysplasia, without frank carcinoma, abnormal expression of p53, cyclin D1 or p16 was detected. Kim et al. [16] reported that the mutation of the p53, p16, and K-ras genes occurred at rates of 36%, 31% and 20%, respectively, in GBC. A further finding of the above study was ...
Outcomes of vaginal reconstructive surgery with and without graft material. The incidence of urinary tract injury during hysterectomy: A prospective analysis based on universal cystoscopy
HZI-Scientists have elucidated which bacteria block artificial bile ducts.  A consequence of the different cancers of the hepatobiliary system is blocked bile ducts. However, artificial catheters known as stents can remediate this problem. Stents …
Zhumadilov, Z.S., Skuba, N.D. & Makarenkova, R.V. Experimental study of oriented antibiotic transport in suppurrtive-inflammatory diseases of the liver and biliary tract. Bull Exp Biol Med 109, 592-596 (1990). https://doi.org/10.1007/BF00839875. Download ...
Why do you need an MRI of the liver and biliary tract and where to do it. Indications and contraindications for the study. Preparation for magnetic resonance imaging.
ဝမ္းဗိုက္နာျခင္း၊ေအာင့္ျခင္းသည္ ဂတ္စ္ သို႔ အစာမေၾကျခင္း ေၾကာင့္ ျဖစ္တတ္ေသာ ပံုမွန္ျဖစ္ရိုးျဖစ္စဥ္တစ္ခုျဖစ္နိုင္ပါတယ္။ သို႔ေသာ္လည္း ရိုးရိုးနာျခ
Biliary-enteric anastomosis (BEA) is a common surgical procedure performed for the management of biliary obstruction or leakage that results from a variety of benign and malignant diseases. Complications following BEA are not rare. We aimed to determine the incidence and the factors associated with early complications occurring after BEA for benign diseases. We reviewed the medical records of all patients who underwent BEA for benign diseases at our institution between January 1988 and December 2009. The primary outcome was early post operative complication. Logistic regression analysis was done to identify factors predicting the occurrence of complications. Records of 79 patients were reviewed. There were 34 (43%) males and 45 (57% females). Majority (53%) had choledocholithiasis with impacted stone or distal stricture, followed by traumatic injury to the biliary system (33%). Thirty-four patients (43%) underwent a hepaticojejunostomy, 19 patients (24%) underwent a choledochojejunostomy, and
[Biliary tract cyst after Kasai portoenterostomy in extrahepatic biliary tract atresia and its relationship with repeated cholangitis].:
The biliary tract, (biliary tree or biliary system) refers to the liver, gall bladder and bile ducts, and how they work together to make, store and secrete bile. Bile consists of water, electrolytes, bile acids, cholesterol, phospholipids and conjugated bilirubin. Some components are synthesised by hepatocytes (liver cells), the rest are extracted from the blood by the liver. Bile is secreted by the liver into small ducts that join to form the common hepatic duct. Between meals, secreted bile is stored in the gall bladder. During a meal, the bile is secreted into the duodenum to rid the body of waste stored in the bile as well as aid in the absorption of dietary fats and oils. The biliary tract refers to the path by which bile is secreted by the liver then transported to the duodenum, the first part of the small intestine. A structure common to most members of the mammal family, the biliary tract is often referred to as a tree because it begins with many small branches which end in the common ...
(HealthDay) -- For patients with biliary tract cancers, postresection adjuvant therapy with chemotherapy or chemoradiotherapy appears to be beneficial in treating patients with biliary tract cancers, with significant improvement ...
Section 2. Liver and Biliary Tract Disease. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. Longo D.L., Fauci A.S., Kasper D.L., Hauser S.L., Jameson J, Loscalzo J Eds. Dan L. Longo, et al.eds. Harrisons Principles of Internal Medicine, 18e New York, NY: McGraw-Hill; 2012. http://accesspharmacy.mhmedical.com/content.aspx?bookid=331§ionid=40727095. Accessed February 19, 2018 ...
Semantic Scholar extracted view of D-glucitol in the treatment of biliary tract disease; preliminary observations. by N W CHAIKIN
A Tc-99m-labelled compound with the biological characteristics of flumazenil would be useful for determination of neuronal viability after the onset of a stroke. Therefore, we have derivatized Ro-15-3890 (a flumazenil metabolite bearing a carboxylic acid group instead of an ethyl ester) by coupling it with a bisamino bisthiol tetraligand bearing a 3-hydroxypropyl side chain (3-hydroxypropyl-BAT) to enable labelling with technetium-99m. After purification by RP-HPLC, the ligand was deprotected and labelled in a one pot reaction, yielding a Tc-99m-BAT-propylester of Ro-15-3890 (Tc-99m-techmazenil). Radio-LC-MS analysis of the isolated main peak showed the molecular ion mass (608.0618) of the expected Tc-99m-techmazenil. The biodistribution of Tc-99m-techmazenil was investigated in normal mice and indicated that the tracer is cleared from plasma mainly by the hepatobiliary system and shows a very low uptake in brain. In vitro binding studies on mice brain slices indicated that techmazenil does ...
Theres no doubt Ive always wanted to; its been a combination of running low on ideas, and the taking over of my mind by the disignorable realities of politics, of our nation, our world. And it was easy: every day there are outrages aplenty, no end of blogfodder, as the evidence of devolution of our politics is everywhere. I suppose I got a few things out, decongested my hepatobiliary system. But really, it was the ever-truth that nothing I said on my other blog mattered. I always knew it. I dont know what led to the final recogniton that there was no point. Partly, I think, it was re-reading some posts over here, and the comments they engendered. Its not cold fusion, but I think it was useful, once in a while adding something to the common good, if only a tiny blip ...
Bioarray offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request ...
The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is more than 60 days but less than or equal to 180 days. The sponsor cannot require changes to the communication and cannot extend the embargo ...
hepatobiliary pancreatic twelve intestines section structural model of gastric gastroenterology medical whipple gasen xh001 в наличии / купить в один клик в нашем интернет- ...
At the Complex HPB Institute at Denver Health, our team provides comprehensive care for complex liver, pancreas and biliary tract diseases.
By sharing our collective experience through interesting patient cases, we can make a real difference in how people are imaged and diagnosed. Each case belongs to a contributing member, which can then be viewed and added to articles or playlists by the community, and is guided by dedicated editors to match quality standards and privacy needs. Upload new case ...
Effects of In Vivo Hepatic Ischemia-Reperfusion Injury on the Hepatobiliary Disposition of Rhodamine 123 and its Metabolites in Isolated Perfused Rat Livers
TY - JOUR. T1 - Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance. AU - Ahn, Daniel. AU - Javle, Milind. AU - Ahn, Chul W.. AU - Jain, Apurva. AU - Mikhail, Sameh. AU - Noonan, Anne M.. AU - Wu, Christina. AU - Shroff, Rachna T.. AU - Chen, James L.. AU - Bekaii-Saab, Tanios. PY - 2016/12/1. Y1 - 2016/12/1. N2 - BACKGROUND: Biliary tract cancers (BTCs) are uncommon and are associated with a dismal prognosis. Combinations of gemcitabine and platinum chemotherapy (gemcitabine and platinum-based therapy [GP]) form the standard approach for treating advanced BTC. To characterize the spectrum of mutations and to identify potential biomarkers for a GP response in BTC, this study evaluated the genomic landscape and assessed whether mutations affecting DNA repair were associated with GP resistance. METHODS: Pretreatment, formalin-fixed, paraffin-embedded samples from 183 BTC patients treated with GP were analyzed. ...
The biliary tree consists of intrahepatic and extrahepatic bile ducts and is lined by biliary epithelial cells (or cholangiocytes). There are also peribiliary glands around the intrahepatic large bile ducts and extrahepatic bile ducts. The biliary tr
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Catheter apparatus for performing diagnostic and therapeutic modalities in the biliary tree includes a catheter with multiple lumens. A first lumen is adapted to receive a guidewire and can serve as a transport lumen for contrast agent. A second lumen carries a cutting wire for performing a sphincterotomy. A third lumen can be used as an inflation lumen for a distally located balloon. Expansion of the balloon occludes a portion of the biliary tree and allows the catheter to sweep any gallstones through the sphincter of Oddi into the duodenum.
Are willing to provide blood/serum/plasma and tumor tissue samples for research purposes. Submission of blood/serum/plasma and tumor tissue samples is mandatory for participation in this study, unless restricted per local regulations ...
Patients, Platinum, Tyrosine, Attention, Biliary Tract, Biliary Tract Cancer, Cancer, Chemotherapy, Cisplatin, Collaboration, Confidence Interval, Identification, Inhibition, Investigators, Japanese, Prognosis, Progression-free Survival, Sepsis, Survival, Treatment
biliary tree ultrasound education showing how to, normal, anatomy, scanning protocol, measurements, bile duct, hepatic duct and dilatation.
10.1055/b-0039-168054 Part 1 Hepatobiliary Case 1Rocky C. Saenz Fig. 1.1 Unenhanced axial CT image (a) demonstrates a hypodense mass within the left lobe. The mass demonstrates peripheral nodular enhancement on arterial phase imaging with a central hypodense scar (b). On venous phase imaging (c), the mass is hyperdense to surrounding hepatic parenchyma. On delayed imaging…
LIVER,GB, Biliary Tree - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online.
Know the structural, functional, and congenital abnormalities, inflammatory pathology, and neoplastic diseases of the esophagus, stomach, appendix, colon, liver, biliary system, pancreas, spleen ...
MEDICAL DISCLAIMER: Talk to your doctor before making any changes in your course of treatment. The information provided in this website should be relied upon for medical education purposes only. It is not intended to replace the independent judgment of a health care provider. The appropriateness of a course of treatment for a patient may vary from the medical information provided herein due to individual conditions and/or complications. ...
1970, c. 37, s. 52; 1971, c. 47, s. 13; 1973, c. 46, s. 43, s. 44, s. 49; 1973, c. 49, s. 40, s. 41, s. 45; 1973, c. 51, s. 39, s. 40, s. 46; 1973, c. 52, s. 27, s. 28, s. 31; 1977, c. 5, s. 229; 1979, c. 1, s. 41; 1979, c. 77, s. 34; 1979, c. 63, s. 329; 1979, c. 45, s. 150; 1981, c. 9, s. 7; 1981, c. 22, s. 20; 1982, c. 53, s. 57; 1984, c. 47, s. 209; 1985, c. 21, s. 18; 1985, c. 23, s. 24; 1986, c. 95, s. 20; 1988, c. 41, s. 88; 1988, c. 82, s. 215; 1990, c. 19, s. 11; 1991, c. 42, s. 577; 1992, c. 19, s. 6; 1991, c. 42, s. 577; 1992, c. 44, s. 81; 1992, c. 21, s. 108, s. 375; 1993, c. 51, s. 17; 1994, c. 8, s. 12; 1994, c. 12, s. 16; 1994, c. 15, s. 34; 1994, c. 16, s. 50; 1994, c. 17, s. 76; 1994, c. 40, s. 457; 1996, c. 29, s. 43; 1996, c. 21, s. 33; 1997, c. 63, s. 128; 1997, c. 73, s. 90; 1998, c. 39, s. 180; 1999, c. 36, s. 37; 1999, c. 89, s. 33, s. 42; 2001, c. 24, s. 105; 2001, c. 44, s. 30; 2002, c. 66, s. 20; 2004, c. 11, s. 62; 2005, c. 11, s. 22; 2005, c. 24, s. 22; 2005, c. 28, ...
We have reported a case series and a large disease association study including over 23,000 patients with ADPKD. Our case series findings suggested that biliary tract disease is as frequent in people with ADPKD as serious liver complications and that it has a distinct clinical presentation and sex distribution. Our disease association study confirmed that hospitalization for biliary tract disease is more common among people with ADPKD than people without and that the absolute excess risk was larger than for serious liver complications and a range of other better described extrarenal manifestations of ADPKD.. The Halt Progression of Polycystic Kidney Disease Study A (HALT-PKD-A) has characterized the biliary tract and liver imaging features of ADPKD.23 Common bile duct dilation was present in 17% of the cohort, but it was the only biliary tract abnormality described. These data corroborate earlier observations from a Japanese study of 55 people with ADPKD, where the prevalence of common bile duct ...
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Observation is watching a patients condition but not giving treatment until symptoms appear. It is not yet known whether giving gemcitabine hydrochloride together with oxaliplatin is more effective than observation in treating patients with biliary tract cancer that has been removed by surgery.. PURPOSE: This randomized phase III trial is studying giving gemcitabine hydrochloride together with oxaliplatin to see how well it works compared with observation in treating patients with biliary tract cancer that has been removed by surgery. ...
Andriamiarina, R.; Laraki, L.; Pelletier, X.; Debry, G., 1989: Effects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in rats
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
Methylenedianiline (4,4-diaminodiphenylmethane, DAPM), a compound used to produce polyurethanes and epoxy resins, rapidly injures biliary epithelial cells (BEC) of rats in vivo. DAPM also increases biliary inorganic ...
For more than 20 years, BroadcastMed has been innovating digital strategies for healthcare organizations. The company was first in the world to broadcast live surgeries on the internet using its ORLive solution which provides an intimate look inside the operating room.. ...
For more than 20 years, BroadcastMed has been innovating digital strategies for healthcare organizations. The company was first in the world to broadcast live surgeries on the internet using its ORLive solution which provides an intimate look inside the operating room.. ...
Computed Tomography (CT or CAT) Scan of the Liver and Biliary Tract Podcast Detailed information on computed tomography (CT or CAT scan) of the liver and biliary tract, including the reasons and preparation for the procedure, how the procedure is performed, after care, and an anatomical illustration of the liver and biliary system. Play Audio ...
Mark Garcia, chief of Interventional Radiology at Christiana Care Health System in Newark, Delaware, is the first physician in the USA to treat a patients biliary stricture with the new Supera Veritas system. "The Superas high radial strength is uniquely suited for treating biliary strictures. Because of its characteristics, I have deployed a number of Supera stents over the past year. This new delivery system worked flawlessly. The driving mechanism was smooth and very responsive. The post-procedure images revealed optimal stent placement with excellent cholangiographic results and patency. I am very pleased with the result.". "We are thrilled to get positive feedback on the initial deployment of the Supera Veritas system in the USA," said Christopher M Owens, president and CEO of IDEV. "The US experience mirrors that of our customers in Europe and Canada, where the Supera Veritas system has been in use for the past year. The stents radial strength and flexibility combine to produce ...
Cholangitis is an inflammation of the bile ducts where stones from the gallbladder become lodged, obstructing flow of bile from the liver to the intestine.
Bioarray offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request ...
KIMS Liver Transplant Program offers a comprehensive and multi-disciplinary approach to the treatment of irreversible liver disease, which has fostered excellent results in patient survival and quality of life. At KIMS, you will have access to doctors from Hepatobiliary, Pancreatic and other areas, all with special training and experience in liver, biliary and pancreatic diseases.. ...
Sugical Veterinarian Hospital in San Diego. Please come in and visit us today to learn more about our Pet Surgical services. Please call 858-676-1600 today.
Sean Mulvihill, MD has specialized expertise in the treatment of diseases of the liver, biliary tract, and pancreas. He is board certified in general surgery. H
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Understanding the key mechanistic and biologic processes in cholangiocytes is required to generate hypotheses and therapies relevant to disease. This compendium of current activities in cholangiocyte biology may promote collegial sharing and exchange of novel concepts, ideas, reagents and probes, th …
STRENGTHENING BUSINESS PLATFORM IN CHINA TO ADDRESS DIVERSE MEDICAL NEEDS Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, Eisai) announced today that its China holding company Eisai China...
Enzymatic therapy whole body cleanse: tlie region of pericardial didiiess (si!c the hlaek spnci'), the limits of whicli are not d(scrh»'d. enzymatic therapy sleep tonight canada ments were recently objected to by a minority of the senatus.
Researchers in radiology at Memorial Sloan Kettering continue to assess multiple imaging methods in the quest to improve treatment options and success rates for patients with biliary cancers such as cholangiocarcinoma.
Published ahead of print, a study in the Alimentary Pharmacology & Therapeutics compares major adjuvant therapies for biliary tract cancer in terms of patient survival rates after resection and toxic effects.. ...
We offer a multidisciplinary treatment for patients suffering from both benign and cancerous conditions of the liver, pancreas and biliary system.
Scenario: I have a Dr. who performed a Guide Wire Dilation of the biliary tract with a graduated Dilator. Ther only Code with Dilation in the ERCP fam
https://doi.org/10.18632/oncotarget.14018 Weiqin Jiang, Yongfeng Ding, Yifei Shen, Longjiang Fan, Linfu Zhou, Zhi Li, Yi Zheng, Peng Zhao, Lulu Liu, Zhou Tong, Weijia Fang, Weilin Wang
This fellowship is clinically oriented, which helps provide fellows with a broad exposure to all aspects of hepatobiliary surgery.
Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11), is a potent anticancer drug that is increasingly used in chemotherapy. A frequent limiting side effect involves gastrointestinal toxicity (diarrhea), which is thought to be related to the biliary excretion of CPT-11 and its metabolites. Accordingly, the biliary excretion mechanisms for both the lactone and carboxylate forms of CPT-11 and its metabolites, SN-38 and its glucuronide (SN38-Glu), were investigated using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR), with the latter being mutant rats with a genetic deficiency of the canalicular multispecific organic anion transporter. After i.v. administration of CPT-11, the biliary excretion clearance, defined as the biliary excretion rate normalized to the hepatic concentration, of both the lactone and carboxylate forms of SN38-Glu was much lower in EHBR. The biliary excretion clearance for the carboxylate form of both CPT-11 and SN-38 was ...
Looking for online definition of OTTHUMP00000164186v multidrug resistance-associated protein 9 in the Medical Dictionary? OTTHUMP00000164186v multidrug resistance-associated protein 9 explanation free. What is OTTHUMP00000164186v multidrug resistance-associated protein 9? Meaning of OTTHUMP00000164186v multidrug resistance-associated protein 9 medical term. What does OTTHUMP00000164186v multidrug resistance-associated protein 9 mean?
Study Details. The study involved 2,934 adult patients diagnosed with biliary tract cancer between 1990 and 2017 identified from the UK Clinical Practice Research Datalink electronic medical record database. Use of postdiagnosis aspirin was defined as one or more prescription at or after biliary tract cancer diagnosis or receipt of an aspirin prescription within 30 days of diagnosis.. Analysis was adjusted for age at diagnosis, sex, comorbidities, statin use at diagnosis, indicators of a healthy lifestyle, and year of diagnosis. Among the 2,934 patients, 667 (23%) had gallbladder cancer, 1,159 (53%) had cholangiocarcinoma, 224 (8%) had ampulla of Vater cancer, and 484 (16%) had overlapping biliary tract cancer lesions.. Results. Death occurred in a total of 2,415 patients (82%), with a reported median overall survival of 5.8 months. In total, 256 patients (9%) were aspirin users at baseline, and an additional 349 (12%) initiated aspirin use after diagnosis; 96% of aspirin users were prescribed a ...
In recent years, our knowledge about the pathogenesis, pathophysiology and treatment of hepatobiliary diseases has increased considerably. The molecular basis of cholestatic disorders as well as of gallstone disease is increasingly recognized. This has resulted in improved diagnosis, for instance in hereditary forms of intrahepatic cholestasis, and advances in treatment, for example in primary biliary cirrhosis and other chronic cholestatic disorders. This book, the proceedings of a Falk Workshop held in Cluj-Napoca, Romania, on June 9-10, 2000, brings together contributions from scientists and clinicians to highlight the most recent advances in molecular biology, pathophysiology, diagnosis and therapy of diseases of the hepatobiliary system. World experts cover a broad spectrum of topics from genetic studies to endoscopy and from medical treatment to liver transplantation.Acalovschi, M. is the author of Hepatobiliary Diseases Cholestasis and Gallstone with ISBN 9780792387701 and ISBN ...
90. , et al. Adenocarcinoma of the gallbladder in two siblings. Cancer 1982; 50:1200-1203. 91. Garber JE, Shipley W. Carcinoma of the gall bladder in three members of a family. Cancer Genet Cytogenet 1989; 39:141142. 92. Andreotti G, Chen J, Gao YT, et al. Serum lipid levels and the risk of biliary tract cancers and biliary stones: a populationbased study in China. Int J Cancer 2008 May 15;122(10): 14 I ∙ GENERAL CONSIDERATIONS 2322-9. 93. Hsing AW, Gao YT, Han TQ, et al. Gallstones and the risk of biliary tract cancer: a population-based study in China. The Hague, Boston, Hingham, MA: M. Nijhoff, Distributors for the United States and Canada, Kluwer Boston, 1982. 62. Goodman MT, Yamamoto J. Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002. Cancer Causes Control 2007; 18:415-422. 63. Cobb N, Paisano RE. Patterns of cancer mortality among Native Americans. Cancer 1998; 83:2377-2383. 64. Nutting PA, Freeman WL, Risser DR, et al. ...
Liver, Biliary Tract and Pancreas, 2nd Edition, part 3 in the 3-book Digestive System volume, provides a concise and highly visual approach to the basic sciences and clinical pathology of the hepatobiliary system and pancreas. This book in The Netter Collection of Medical Illustrations (the CIBA "Green Books") has been expanded and revised to capture current perspectives in hepatology, pancreatology, and gastroenterology - from normal anatomy and physiology through pathophysiology, diagnostics and treatment of the liver, pancreas, and biliary tract. It also features radiologic and pathologic images to supplement the classic Netter illustrations, as well as new illustrations. This this updated classic is ideal for students and health professionals seeking an easily accessible guide to the digestive system.. ...
p16Ink4 and p15Ink4B are cyclin-dependent kinase 4 inhibitors and link to the regulation of cell cycle in mammalian cells. The genes encoding these inhibitors are located at 9p21, which is a frequent site of allelic loss in various types of tumors. Twenty-five primary biliary tract cancers were examined for somatic mutations in p16Ink4/CDKN2, p15Ink4B/MTS2, p53, and K-ras genes and allelic loss of 9p21 by microsatellite analysis. Four biliary tract cancer cell lines were analyzed for homozygous deletions and point mutations. We found frequent homozygous deletions in p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in the biliary tract cancer cell lines. Each cancer cell line had alteration of either p16Ink4/CDKN2, p15Ink4B/MTS2, or p53 genes. In primary tumors, 16 of 25 (64%) biliary tract cancers had point mutations in the p16Ink4/CDKN2 gene. These include 14 missense and 2 silent mutations. The frequency of mutations in gall bladder cancer and hilar bile duct cancer were 80% (8 of 10) and 63% (5 of 8), ...
Hepatic (biliary) cystadenomas are rare multilocular cystic tumors of the liver that are derived from the biliary epithelium and are predominantly located in the right hepatic lobe. These tumors usually involve the hepatic parenchyma (approximately 85% of cases) and occasionally the extrahepatic biliary tract.
Background Biliary tract cancers (BTCs) are relatively rare neoplasms encompass both cholangiocarcinoma (CC). The role of routine lymphadenectomy at the time of surgical resection remains poorly defined. We sought to identify factors associated with outcome following and examine the impact of lymph node (LN) assessment on survival.. Methods 43 patients who underwent curative intent surgery between 2000-2010 were identified from a database. We calculated prognostic factors and impact lymph node (LN) assessment for survival.. Results A total of 43 patients were identified with no metastatic BTCs. The median age was 65 years (29-82 years); performance status of 0 in 33/43 (76%); PS1 in 8/43 (19%) and PS2 in 2/43 (5%) pts. A histological diagnosis of adenocarcinoma was confirmed in 100%. Surgical resection was performed in all patients. After resection 42% (18/43) had positive nodes.Adjuvant chemotherapy had 31/43(72%), preferred with gemcitabine and a median number of cycles 6. Grade 3 or 4 ...
The overall goal of this study was to assess the potential of MPM imaging for real-time, high-resolution contrast-free visualization of both the normal GI tract and GI diseases linked to malignancy. To accomplish this, an MPM atlas of images of the entire normal mouse GI tract from the esophagus to the anus, including the organs of the hepatobiliary system and pancreas was generated. Next, mouse models of experimental colitis and colorectal neoplasia were imaged. MPM imaging was then used to visualize tissues from several diseases linked to GI malignancy including celiac sprue, IBD, and colonic neoplasia. MPM images generated from tissues of both experimental models and human subjects recapitulated all essential aspects of histology found in H&E-stained sections. Finally, the feasibility of carrying out MPM imaging of the GI tract in vivo was established.. Previously, MPM imaging has been used to visualize the normal and diseased mouse GI tract (23, 24, 29, 30, 36). For example, DSS-induced ...
TY - JOUR. T1 - Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin. AU - Watkins, J. B.. AU - Sherman, S. E.. PY - 1992/1/1. Y1 - 1992/1/1. N2 - The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation. Urinary excretion of acetaminophen was increased 280%, whereas biliary excretion was decreased 65% and total clearance was unchanged. Both steady-state volume of distribution and elimination half-life of acetaminophen were decreased in diabetic rats by 23 and 25%, respectively. Biliary excretion of glucuronide and sulfate conjugates was decreased by 75 and 50%, respectively, whereas parent acetaminophen excretion was unchanged. The glutathione conjugate was only detected in normal and insulin-treated rats; however, comparable levels of a cysteine conjugate were detected in bile ...
download surgical pathology of the gi tract, liver, biliary tract, and; floodplain; P, The stability and surveillance of basics in this progress provide from that of non-binding purposes. In way I, we understand the major sites of the four places of hydrology. OLINK, has the crochet of voting and is how it is to the ways and assumptions. This download surgical pathology of the gi tract, liver, biliary screenings significantly safeguards how voters have the Cross-cultural screening. days was adjacent to See us to be into limited areas reading during the download relaxometry of water-metal ion interactions of the previous. In other 29 important addresses learned used visualising a Ethiopian linked here of interventions, from emissions and project funds to descriptions committed by rate. How to review it: difficulties to terrorist download surgical pathology for Renaissance Solutions. 10)Brofenbrenner Urie, Kessel Frank, Kessen William, and White Sheldon( 1986). Toward a relevant FREE download ...
MILLAR, A J W. Solving difficult hepatobiliary problems in children. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.11, pp.872-875. ISSN 2078-5135.. Most difficult hepatobiliary (HPB) problems in infancy and childhood result from pathological anatomical/mechanical derangements; therefore, surgery on the liver and bile ducts depends on a detailed understanding of liver structure, function and repair response to injury or disease. The surgeon must be aware of the very diverse range of anatomical variations. Perhaps key to improving the outcome of paediatric HPB surgery is centralised management and associating this with a paediatric liver transplant programme, which adds expertise and, frequently, the added benefit of adult HPB surgical input to paediatric surgical care. In the United Kingdom, this has resulted in excellent measurable benefit, particularly in the management of biliary atresia, but also of choledochal cysts, portal hypertension and liver tumours. These conditions are briefly ...
Peritumoral ductular reaction: a poor postoperative prognostic factor for hepatocellular carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
This study evaluates the combination chemotherapy with gemcitabine, irinotecan and panitumumab in patients with advanced biliary cancer.
Know more about biliary disorders and the symptoms, causes, treatment and risk factors of gallbladder stones. Any changes in the bile juice can result in formation of small pebble like stones in the gallbladder, commonly called as gallstones.
Free, official information about 2014 (and also 2015) ICD-9-CM diagnosis code 646.7, including coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion.
Previous studies suggest that LPS-induced cholestasis is mediated by impairment of the hepatobiliary transporting systems involved in the formation of bile. To date, several genes encoding hepatobiliary transporters localized to sinusoidal or canalicular membranes of hepatocytes have been cloned. It has been shown that LPS-mediated repression of hepatobiliary transporters is principally the result of down-regulation of gene expression (Green et al., 1996; Moseley et al., 1996; Trauner et al., 1997, 1998; Vos et al., 1998). Consistent with these published studies on other transporters, the present data demonstrate that LPS treatment also produces a time-dependent decrease in mouse Oatp4 mRNA levels (Fig. 1). Oatp4 mRNA levels return to control values after a single injection of LPS, indicating that the effects of LPS on Oatp4 mRNA are reversible in this model. Among the rat Oatps, Oatp4 mRNA levels have been shown to be relatively high in liver (Li et al., 2002). Oatp4 mediates Na+-independent ...
Methods We performed a retrospective observational study of MRCP studies (n = 119) performed between October 2011 and September 2012 at West Middlesex University Hospital using electronic medical records. All MRCPs were reported by a consultant radiologist. MRCP findings were correlated with the presence of dilated (but otherwise normal) or undilated biliary tree on initial imaging (USS/CT), jaundice (bilirubin , 21 μmol/L) and abdominal pain. Demographics including age and gender were noted. Fishers exact test was used to analyse binary variables and students T test for continuous variables using the STATA12 statistical software. ...
Disorders of the biliary tract affect a significant portion of the worldwide population, and the overwhelming majority of cases are attributable to cholelithiasis (gallstones). In the United States, 20% of persons older than 65 years have gallstones and 1 million newly diagnosed cases of gallstones are reported each year.
The biliary tract can also serve as a reservoir for intestinal tract infections. Since the biliary tract is an internal organ, ... The biliary tract, (biliary tree or biliary system) refers to the liver, gall bladder and bile ducts, and how they work ... it has no somatic nerve supply, and biliary colic due to infection and inflammation of the biliary tract is not a somatic pain ... The biliary tract refers to the path by which bile is secreted by the liver then transported to the duodenum, the first part of ...
Biliary tract. Bile ducts. *Intrahepatic bile ducts *Bile canaliculus. *Canals of Hering ...
Biliary tract. Bile ducts. *Intrahepatic bile ducts *Bile canaliculus. *Canals of Hering ... This pain, known as biliary colic, is sometimes referred to as a gallbladder "attack" because of its sudden onset. ...
"Biliary Tract Diseases". nih.gov. Retrieved 24 December 2016. "Pancreatic Diseases". nih.gov. Retrieved 24 December 2016. "NLM ... biliary tract and pancreas 2. MeSH (medical subject heading): G02.403.776.409.405 same as "Gastroenterology" C06.552 Liver ... National Library of Medicine Catalogue WI 700-740 Liver and biliary tree Diseases WI 800-830 Pancrease Also see Hepato-biliary ... Hepatology is the branch of medicine that incorporates the study of liver, gallbladder, biliary tree, and pancreas as well as ...
Biliary Tract Saga". Ann. Surg. 238 (5): 772-775. doi:10.1097/01.sla.0000094443.60313.da. PMC 1356158. PMID 14578742.. ... Biliary Tract Saga". Ann. Surg. 238 (5): 772-775. doi:10.1097/01.sla.0000094443.60313.da. PMC 1356158. PMID 14578742.. .mw- ...
Biliary tract disease: a rare manifestation of eosinophilic gastroenteritis. „Digestive diseases and sciences". 3 (48), s. 624- ... Eosinophilic infiltrates of the gastrointestinal tract. „Journal of clinical pathology". 1 (39), s. 1-7, styczeń 1986. PMID: ...
... gallbladder and biliary tract. This shares a name with the Kocher incision used for thyroid surgery: a transverse, slightly ... It has also been proposed for surgery of the upper urological tract. Cherney Incision - developed in 1941 by the American Uro- ... the digestive tract (the stomach, duodenum, jejunum, ileum and colon) the liver, pancreas, gallbladder, and spleen the bladder ...
Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas. pp. 653-80. doi:10.1016/B978-141604059-0.50028-X. ISBN ... Pulmonary neuroendocrine cells in the respiratory tract are known as bronchial Kulchitsky cells.[4] ... Graeme-Cook, Fiona (2009). "Neuroendocrine Tumors of the GI Tract and Appendix". In Odze, Robert D.; Goldblum, John R. (eds.). ... They reside alongside the epithelium lining the lumen of the digestive tract and play a crucial role in gastrointestinal ...
de Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM (October 1999). "Biliary tract cancers". New England Journal of ... Chapman RW (1999). "Risk factors for biliary tract carcinogenesis". Annals of Oncology. 10 Suppl 4 (Suppl 4): 308-11. doi: ... Szklaruk J, Tamm E, Charnsangavej C (October 2002). "Preoperative imaging of biliary tract cancers". Surgical Oncology Clinics ... Rajagopalan V, Daines WP, Grossbard ML, Kozuch P (June 2004). "Gallbladder and biliary tract carcinoma: A comprehensive update ...
Other biliary tract cancers include gallbladder cancer and cancer of the ampulla of Vater. Cholangiocarcinoma is a relatively ... West J, Wood H, Logan R, Quinn M, Aithal G (2006). "Trends in the incidence of primary liver and biliary tract cancers in ... de Groen P, Gores G, LaRusso N, Gunderson L, Nagorney D (1999). "Biliary tract cancers". N Engl J Med. 341 (18): 1368-78. doi: ... Szklaruk J, Tamm E, Charnsangavej C (2002). "Preoperative imaging of biliary tract cancers". Surg Oncol Clin N Am. 11 (4): 865- ...
Robert D. Odze, John R. Goldblum: Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas. Elsevier Health ... Endoscopic mucosal resection for early cancers of the upper gastrointestinal tract. „J Clin Oncol". 23 (20), s. 4490-4498, Jul ...
The biliary tract is derived from the branches of the bile ducts. The biliary tract, also known as the biliary tree, is the ... ISBN 978-81-8061-833-8. McMinn, R. M. H. (2003). "Liver and Biliary Tract". Last's Anatomy: Regional and Applied. Elsevier. pp ... The bipotential hepatoblasts begin differentiating into biliary epithelial cells and hepatocytes. The biliary epithelial cells ... Primary biliary cholangitis is an autoimmune disease of the liver. It is marked by slow progressive destruction of the small ...
a b c d e f g h i j k l m Friedman L.S. (2015). Liver, Biliary Tract, & Pancreas Disorders. In Papadakis M.A., McPhee S.J., ... have biliary colic each year.[5] If untreated, about 20% of people with biliary colic develop acute cholecystitis.[5] Once the ... "Revised estimates of diagnostic test sensitivity and specificity in suspected biliary tract disease". Arch. Intern. Med. 154 ( ... "Journal of Hepato-Biliary-Pancreatic Surgery. 14 (1): 15-26. doi:10.1007/s00534-006-1152-y. ISSN 0944-1166. PMC 2784509. PMID ...
"Revised estimates of diagnostic test sensitivity and specificity in suspected biliary tract disease". Arch Intern Med. 154 (22 ... Cholescintigraphy or hepatobiliary scintigraphy is scintigraphy of the hepatobiliary tract, including the gallbladder and bile ... Cholescintigraphic scanning is a nuclear medicine procedure to evaluate the health and function of the gallbladder and biliary ... If the noninvasive ultrasound examination fails to demonstrate gallstones, or other obstruction to the gallbladder or biliary ...
Biliary Tract, & Pancreas Disorders. In Papadakis M.A., McPhee S.J., Rabow M.W. (Eds), Current Medical Diagnosis & Treatment ... When a gallstone lodges in the cystic duct, they experience biliary colic. Biliary colic is abdominal pain in the right upper ... Of all people with stones, 1-4% have biliary colic each year. If untreated, about 20% of people with biliary colic develop ... "Revised estimates of diagnostic test sensitivity and specificity in suspected biliary tract disease". Arch. Intern. Med. 154 ( ...
Liver, Biliary Tract, & Pancreas Disorders. ISBN 978-0071806336. Li CP, Lee FY, Hwang SJ, et al. (1999). "Spider angiomas in ... Imaging of the bile ducts, such as ERCP or MRCP (MRI of biliary tract and pancreas) may aid in the diagnosis. Macroscopically, ... Primary biliary cholangitis (also known as primary biliary cirrhosis). The bile ducts become damaged by an autoimmune process, ... In primary biliary cholangitis, there is fibrosis around the bile duct, the presence of granulomas and pooling of bile. Lastly ...
Biliary tract dilation due to obstruction. Most patients presenting with jaundice will have various predictable patterns of ... The pathology is located after the conjugation of bilirubin in the liver caused due to obstruction of biliary passage.[14]. ... This conjugated bilirubin is excreted from the liver into the biliary and cystic ducts as part of bile. Intestinal bacteria ... In addition, swelling of cells and oedema due to inflammation cause mechanical obstruction of intrahepatic biliary tree. Hence ...
Non-cardiac symptoms include impairments of the liver and gastrointestinal tract. Biliary atresia, or inflammation and ... Biliary atresia is not usually observed in patients with right atrial isomerism. Random positioning of the stomach is often one ... This biliary atresia can lead to acute problems such as nutrient malabsorption, pale stools, dark urine, and abdominal swelling ... In right atrial isomerism, the pulmonary blood oxygen tract is damaged due to right-left shunting of blood. In addition, the ...
Kumar & Clark's Clinical Medicine e.8 Chapter 7: Liver, biliary tract and pancreatic disease Pg. 335 ... "Ascites - Hepatic and Biliary Disorders". Merck Manuals Professional Edition. May 2016. Retrieved 14 December 2017.. ...
ISBN 0-691-02873-7. Crawford JM, Liver and Biliary Tract. Pathologic Basis of Disease, ed. Kumar V, et al. 2005, Philadelphia: ... bigger spores have a better chance of settling in the upper respiratory tract. The deposition of certain spore sizes could be a ...
It is agreed that the initial operation resulted in biliary tract damage, a complication well recognised at the time and much ... In light of recurrent biliary tract infections, Evans recommended an operation. Three surgeons were recommended and the ... Biliary Tract Saga". Annals of Surgery. 238 (5): 772-775. doi:10.1097/01.sla.0000094443.60313.da. ISSN 0003-4932. PMC 1356158 ...
Pneumobilia means air in the biliary tract. It is due to the transfer of air from bowel through the fistula into the biliary ... tract.[citation needed] Clarke, Christopher (2015). Abdominal X-rays for Medical Students. John Wiley & Sons. p. 33. Rigler LG ...
Patman, G. (2015). "Biliary tract: Newly identified biliatresone causes biliary atresia". Nat Rev Gastroenterol Hepatol. 12: ... It has been found to cause extrahepatic biliary atresia in a zebrafish model. The enone moiety of biliatresone is particularly ... May 2015). "Identification of a plant isoflavonoid that causes biliary atresia". Sci Transl Med. 7: 286ra67. doi:10.1126/ ... 2016). "Reactivity of biliatresone, a natural biliary toxin, with glutathione, histamine, and amino acids". Chem. Res. Toxicol ...
... research on the pathogenesis of biliary tract stones; studies of drug-induced and viral hepatitis and studies on small ... alcohol-related disorders and genetic syndromes of the gastrointestinal tract, to name a few. Giovanni Gasbarrini contribution ...
Surgery of the Liver, Biliary Tract and Pancreas. Philadelphia: Elsevier Inc, 2007 Tseng JF, Pisters PW, Lee JE, et al. (April ... "In-hospital mortality after resection of biliary tract cancer in the United States". HPB (Oxford). 12 (1): 62-67. doi:10.1111/j ... hepato biliary disease, vascular disease, colorectal disease, plastic and reconstructive surgery, and transplant medicine. ... "Surgical specialization and operative mortality in hepato-pancreatico-biliary (HPB) surgery". J. Gastrointest. Surg. 12 (9): ...
"Investigation of liver and biliary disease". BMJ (Clinical research ed.). 322 (7277): 33-6. doi:10.1136/bmj.322.7277.33. PMC ... Upper GI tract. *Nausea/Vomiting. *Heartburn. *Dysphagia (Oropharyngeal, Esophageal). *Halitosis. *Xerostomia. *Hypersalivation ...
The biliary tract can also serve as a reservoir for intestinal tract infections. Since the biliary tract is an internal organ, ... The biliary tract, (biliary tree or biliary system) refers to the liver, gall bladder and bile ducts, and how they work ... it has no somatic nerve supply, and biliary colic due to infection and inflammation of the biliary tract is not a somatic pain ... The biliary tract refers to the path by which bile is secreted by the liver then transported to the duodenum, the first part of ...
This category is located at Category:Biliary system Note: This category should be empty. Any content should be recategorised.. ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Biliary_tract&oldid=113253729" ...
A biliary tract biopsy is the removal of small amounts of cells and fluids from the duodenum, bile ducts, pancreas, or ... A biliary tract biopsy can determine if a tumor started in the liver or spread from another location. It also can determine if ... A biliary tract biopsy is the removal of small amounts of cells and fluids from the duodenum, bile ducts, pancreas, or ... After a physical exam, x-ray, MRI, CT scan, or ultrasound shows abnormal growths in your biliary tract ...
... is the most common disease of the biliary tract. Gallstones are of three types: stones containing primarily calcium ... Biliary tract: Cholelithiasis, or the formation of gallstones in the gallbladder, ... while brown stones may occur in any part of the biliary tract in patients with chronic biliary infections and stasis ( ... Cholelithiasis, or the formation of gallstones in the gallbladder, is the most common disease of the biliary tract. Gallstones ...
Surgical resection Surgery is the only curative modality for biliary tract cancers; surgical resectability of disease should be ... Treatment protocols for biliary tract cancer are provided below, including surgery, adjuvant therapies, systemic therapies, and ... encoded search term (Biliary Tract Cancer Treatment Protocols) and Biliary Tract Cancer Treatment Protocols What to Read Next ... Palliative biliary drainage is often necessary in patients with advanced unresectable biliary tract carcinoma. ...
The biliary tract can also serve as a reservoir for intestinal tract infections. Since the biliary tract is an internal organ, ... The biliary tract, (biliary tree or biliary system) refers to the liver, gall bladder and bile ducts, and how they work ... and biliary colic due to infection and inflammation of the biliary tract is not a somatic pain. Rather, pain may be caused by ... The biliary tract refers to the path by which bile is secreted by the liver then transported to the duodenum, the first part of ...
Biliary Tract and Pancreas - 5th Edition. Print Book & E-Book. ISBN 9781437714548, 9781455746064 ... 13 Ultrasound of the Liver, Biliary Tract, and Pancreas 14 Endoscopic Ultrasound of the Biliary Tract and Pancreas 15 Nuclear ... 16 Computed Tomography of the Liver, Biliary Tract, and Pancreas 17 Magnetic Resonance Imaging of the Liver, Biliary Tract, and ... Biliary Tract, and Pancreas 1B Surgical and Radiologic Anatomy of the Liver, Biliary Tract, and Pancreas 2 Assessment of ...
1) There are no objective findings of impairment of the liver or biliary tract. Subjective complaints may be present or absent. ... or there are occasional episodes of loss of function of the biliary tract, but nutrition and strength are good. ... or there is recurrent biliary tract impairment, but no ascites, jaundice or bleeding esophageal varices and nutrition and ...
... including those for biliary tract cancer, intrahepatic bile duct tumors, perihilar bile duct tumors, and distal bile duct ... The TNM staging classifications for biliary tract cancers are provided below, ... encoded search term (Biliary Tract Cancer Staging) and Biliary Tract Cancer Staging What to Read Next on Medscape. Related ... TNM Classification for Biliary Tract Cancers. The tumor-node-metastasis (TNM) staging classifications for biliary tract cancers ...
Cytology analysis - biliary tract; Biliary tract biopsy. How the Test is Performed. A sample for a biliary tract biopsy can be ... Biopsy - Biliary Tract. Definition. A biliary tract biopsy is the removal of small amounts of cells and fluids from the ... A biliary tract biopsy can determine if a tumor started in the liver or spread from another location. It also can determine if ... After a physical exam, x-ray, MRI, CT scan, or ultrasound shows abnormal growths in your biliary tract ...
Irinotecan, Gemcitabine, Chemotherapy for Biliary Tract Cancer. The safety and scientific validity of this study is the ... irinotecan and gemcitabine will improve local control of cancer and prolong survival in patients with inoperable biliary tract ...
Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials.. Eckel F1, Schmid RM. ... Owing to the lack of randomised controlled trials no standard of chemotherapy exists in the treatment of advanced biliary tract ... Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials ... Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials ...
Biliary Tract and Pancreas, 2-Volume Set - 6th Edition. Print Book & E-Book. ISBN 9780323340625, 9780323340892 ... Blumgarts Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set 6th Edition. ... Blumgarts Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set ... Techniques of Biliary Tract Intervention: Radiologic, Endoscopic, and Surgical. Biliary Tract Disease ...
... have achieved national and international acclaim for treatment of disorders affecting the biliary and pancreas tract. Each year ... Biliary Tract Disorders. Virginia Mason gastroenterologists have achieved national and international acclaim for treatment of ... Virginia Mason gastroenterologists specialize in treatment for the following biliary tract diseases and disorders:. *Bile Duct ... our gastroenterologists offer patients a full spectrum of care for both common and uncommon disorders of the biliary tract and ...
... biliary tract explanation free. What is biliary tract? Meaning of biliary tract medical term. What does biliary tract mean? ... Looking for online definition of biliary tract in the Medical Dictionary? ... Related to biliary tract: gallbladder, biliary tract cancer. tract. [trakt] a longitudinal assemblage of tissues or organs, ... Biliary tract obstruction usually leads to obstructive jaundice.. BILIARY TRACT (IN RELATION TO LIVER, PANCREAS, AND DUODENUM) ...
... pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, ... Only 1/3 of patients have evidence of persistent or ongoing obstruction of the biliary tract that is usually short lived with ... C. P. Armstrong, T. V. Taylor, J. Jeacock, and S. Lucas, "The biliary tract in patients with acute gallstone pancreatitis," ... The aim of the study was to analyze the natural progression of this biochemical marker of biliary tract obstruction in patients ...
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The appropriate management of biliary tract disease during pregnancy is uncertain. Although laparoscopic cholecystectomy can be ... Biliary Tract Diseases / diagnosis, surgery*. Case-Control Studies. Cholecystectomy, Laparoscopic / adverse effects, methods*. ... RESULTS: A comprehensive search of the literature yielded a fetal death rate following LC for biliary tract disease of 2.2% and ... For a hypothetical cohort of 100 women presenting with biliary tract disease in their first trimester, LC generated 12,800 QPWs ...
Purchase Biliary Tract and Primary Liver Tumors, An Issue of Surgical Oncology Clinics of North America - 1st Edition. Print ... Epidemiology and Risk Factors of Biliary Tract Tumors and Primary Liver Tumors; Imaging of the Patient with a Biliary Tract or ... Biliary Tract and Primary Liver Tumors, An Issue of Surgical Oncology Clinics of North America 1st Edition. ... Biliary Tract and Primary Liver Tumors, An Issue of Surgical Oncology Clinics of North America ...
... Koki Kawanishi,1 ... M. Melzer, R. Toner, S. Lacey, E. Bettany, and G. Rait, "Biliary tract infection and bacteraemia: Presentation, structural ... "The clinical epidemiology and outcomes of bacteremic biliary tract infections caused by antimicrobial-resistant pathogens," ...
Buy Biliary Tract and Gallbladder Cancer: Diagnosis and Therapy by Clifton David Fuller From WHSmith today! FREE delivery to ... Novel Biomarkers for Biliary Tract Cancer; Pathological Staging of Gallbladder and Biliary Tract Cancer; Overview of Current ... Surgical Management of Intrahepatic Biliary Tract Cancer; Surgical Management of Extrahepatic Biliary Tract Cancer; Surgical ... Biliary Tract and Gallbladder Cancer: Diagnosis and Therapy. By: Clifton David Fuller (author), Charles R. Thomas (author) ...
Periportal fibrosis, inflammation, and biliary epithelial hyperplasia were found on microscopical examination. Because of the ... but that mechanical obstruction of the intrahepatic bile ducts by flukes raises the pressure within the biliary tree, inducing ... Abstract The liver and biliary tract from 10 autopsies in Udorn, Thailand, where 90% of the population is infected with the ... Biliary Tract Changes in Opisthorchiasis * Hilary Evans*, Curtis H. Bourgeois, Dhira S. Comer, Niyom Keschamras ...
Mucinous cystic neoplasms of the liver and extrahepatic biliary tree have recently been re-defined by WHO as epithelial cystic ... Mucinous Cystic Neoplasms of the Liver and Extrahepatic Biliary Tract, Topics in the Surgery of the Biliary Tree, Hesham ... Mucinous Cystic Neoplasms of the Liver and Extrahepatic Biliary Tract, Topics in the Surgery of the Biliary Tree, Hesham ... Biliary tract along with peribiliary glands has considerable structural similarity with pancreatic ducts and acini. Indeed, the ...
Biliary Tract. This system carries bile into the duodenum (part of the small intestine) and carries other substances to the ... Home Specialties Gatrointestinal Liver and Pancreas Center Conditions and Procedures Biliary Tract ... The biliary tree includes bile ducts, the gallbladder, which stores and concentrates bile, and some cells inside the liver. ...
... but the effect of TIMs in biliary tract cancer remains unclear. The aim of this study is to... ... Biliary tract cancer (BTC), arised from the epithelial cells of the biliary tract, encompassing malignant neoplasms of ... Complete resection is the only potentially curative therapy for patients with biliary tract cancer; however, biliary tract ... In conclusion, TIMs infiltration in biliary tract cancer patients could predict favorable prognosis. Biliary cancer patients ...
  • An obstruction of the biliary tract can result in jaundice , a yellowing of the skin and whites of the eyes. (wikipedia.org)
  • citation needed] An obstruction of the biliary tract can result in jaundice, a yellowing of the skin and whites of the eyes. (wikipedia.org)
  • Numerous studies have shown a high prevalence of common bile duct (CBD) stones or ampullary inflammation with obstruction of the biliary tree in patients operated on early after admission [ 1 , 5 - 8 ]. (hindawi.com)
  • In contrast, mechanical obstruction of the biliary tract is the major factor leading to bacterial degradation and precipitation of biliary lipids in brown pigment stones. (wikipedia.org)
  • Working with specialists throughout Virginia Mason, our gastroenterologists offer patients a full spectrum of care for both common and uncommon disorders of the biliary tract and pancreas. (virginiamason.org)
  • The past Medical history may reveal previous disorders of the biliary tract or duodenum, abdominal trauma or surgery, and metabolic disorders such as diabetes mellitus. (wikipedia.org)
  • Furthermore, biliary pain may be associated with functional disorders of the biliary tract, so called acalculous biliary pain (pain without stones), and can even be found in patients post-cholecystectomy (removal of the gallbladder), possibly as a consequence of dysfunction of the biliary tree and the sphincter of Oddi. (wikipedia.org)
  • The purpose of this study is to evaluate the safety and prognosis of dendritic cell-precision T cell for neo-antigen in the treatment of advanced biliary tract malignant tumor. (clinicaltrials.gov)
  • A number of pathologic conditions, however, resulting in either acute or chronic biliary tract epithelial injury may predispose to malignant change. (wikipedia.org)
  • Congenital biliary cystic disease, such as choledochal cysts or Caroli's disease, has also been associated with malignant transformation in up to 25% of cases. (wikipedia.org)
  • An unmet medical need exists for the successful therapy of patients with advanced hepatocellular and biliary tract malignances, with few and short lived disease responses to chemotherapy for both advanced stage hepatic and biliary carcinomas. (clinicaltrials.gov)
  • The aim of our study was to investigate P-cadherin and CD24 expression in carcinomas and dysplastic lesions of the biliary tract and to evaluate the potential diagnostic usefulness of these cell adhesion molecules. (nih.gov)
  • We conclude that P-cadherin and CD24 are expressed in carcinomas of the biliary tract with high frequency and at an early stage of carcinogenesis. (nih.gov)
  • V. To measure expression profile and mutations of genes critical for EGFR and (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2 signaling pathways with particular relevance to GW572016, and to explore new gene-drug relationships as relating to hepatocellular and biliary carcinomas. (knowcancer.com)
  • Comprehensive and complete, Blumgart's Surgery of the Liver, Pancreas and Biliary Tract - edited by Dr. William R. Jarnagin and a team of experts- delivers the comprehensive, cutting-edge guidance you need to achieve optimal outcomes in surgery of the liver, biliary tract, and pancreas. (elsevier.com)
  • It is agreed that the initial operation resulted in biliary tract damage, a complication well recognised at the time and much corrective surgery was needed later by Richard Cattell, again a recommendation of Evans. (wikipedia.org)
  • It has also been proposed for surgery of the upper urological tract. (wikipedia.org)
  • Surgery of the Biliary Tract: Old Problems New Methods, Current Practice. (wikipedia.org)
  • Langer also served as president of the Canadian Association of General Surgeons, as president of the Society for Surgery of the Alimentary Tract, as the first vice president of the American Surgical Association and as president of the Royal College of Physicians and Surgeons of Canada. (wikipedia.org)
  • It is indicated for use in the following infections: Respiratory tract infections Urinary tract infections Skin infections Biliary tract infections Bone and joint infections Genital infections Blood infections (sepsis) Endocarditis It can also be used peri-operatively to prevent infections post-surgery, and is often the preferred drug for surgical prophylaxis. (wikipedia.org)
  • Professor Michael J. McMahon is a surgeon specialising in upper gastrointestinal surgery, particularly the pancreas and biliary tract. (wikipedia.org)
  • If the biliary system is obstructed, PTC may be used to perform biliary drainage until a more permanent solution for the obstruction is performed (e.g. surgery). (wikipedia.org)
  • Bleeding tendency Biliary tract sepsis Being unfit for surgery Hydatid cysts Ascites CLD (Chronic liver disease) Carter RF, Saypol GM (1952). (wikipedia.org)
  • Bypass operations on the GI tract, once rarely performed, are the cornerstone of bariatric surgery. (wikipedia.org)
  • As of 2017[update], it is not clear whether surgery is indicated for everyone with biliary colic. (wikipedia.org)
  • The name biliary tract is used to refer to all of the ducts, structures and organs involved in the production, storage and secretion of bile. (wikipedia.org)
  • Alkaline phosphatase (ALP) is an enzyme in the cells lining the biliary ducts of the liver. (wikipedia.org)
  • Through the endoscope, the physician can see the inside of the stomach and duodenum, and inject a contrast medium into the ducts in the biliary tree and pancreas so they can be seen on radiographs. (wikipedia.org)
  • The bile duct scarring which occurs in PSC narrows the ducts of the biliary tree and impedes the flow of bile to the intestines. (wikipedia.org)
  • In general, biliary dyskinesia is the disturbance in the coordination of peristaltic contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree into the duodenum. (wikipedia.org)
  • In this respect, it is similar to alkaline phosphatase (ALP) in detecting disease of the biliary tract. (wikipedia.org)
  • The authors are clinicians-the physicians and surgeons of the Medical and Surgical Biliary Tract Clinic of the New York University Hospital, which was founded in 1929. (annals.org)
  • The limitations of MRC include imaging artifact caused by metallic surgical clips and air in the biliary tree. (acpjc.org)
  • These include mother-daughter and SpyGlass cholangioscopes (to help in diagnosis by directly visualizing the duct as opposed to only obtaining X-ray images) as well as balloon enteroscopes (e.g. in patients with post-Whipple or Roux-en-Y surgical anatomy). (wikipedia.org)
  • In addition to pneumonia, Klebsiella can also cause infections in the urinary tract, lower biliary tract, and surgical wound sites. (wikipedia.org)
  • Our model cycles through weeks of pregnancy for a cohort of 200 gravid women presenting with biliary tract disease in both the first and second trimesters. (biomedsearch.com)
  • For a hypothetical cohort of 100 women presenting with biliary tract disease in their first trimester, LC generated 12,800 QPWs compared with 12,400 QPWs for NM, an average gain of 4 QPWs per woman. (biomedsearch.com)
  • In light of recurrent biliary tract infections, Evans recommended an operation. (wikipedia.org)
  • Absolute excess risk of biliary tract disease associated with ADPKD was larger than that for serious liver disease, cerebral aneurysms, and inguinal hernias but less than that for urinary tract infections. (asnjournals.org)
  • Klebsiella ranks second to E. coli for urinary tract infections in older people. (wikipedia.org)
  • Urinary tract: Ureters, urinary bladder, urethra. (wikipedia.org)
  • Cefaclor, developed by Eli Lilly under the trade name Ceclor, is a second-generation cephalosporin antibiotic used to treat some infections caused by bacteria such as pneumonia and infections of the ear, lung, skin, throat, and urinary tract. (wikipedia.org)
  • The cephalosporins are broad-spectrum antibiotics that are used for the treatment of septicaemia, pneumonia, meningitis, biliary tract infections, peritonitis, and urinary tract infections. (wikipedia.org)
  • Cefaclor is frequently used against bacteria responsible for causing skin infections, otitis media, urinary tract infections, and others. (wikipedia.org)