Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Any surgical procedure performed on the biliary tract.
Tumors or cancer of the gallbladder.
A malignant tumor arising from the epithelium of the BILE DUCTS.
Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.
Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).
Tumors or cancer of the BILE DUCTS.
Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.
A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.
Surgical removal of the GALLBLADDER.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
Surgical formation of an opening (stoma) into the COMMON BILE DUCT for drainage or for direct communication with a site in the small intestine, primarily the DUODENUM or JEJUNUM.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.
Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.
Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.
An imaging test of the BILIARY TRACT in which a contrast dye (RADIOPAQUE MEDIA) is injected into the BILE DUCT and x-ray pictures are taken.
Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.
Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.
Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.
A congenital anatomic malformation of a bile duct, including cystic dilatation of the extrahepatic bile duct or the large intrahepatic bile duct. Classification is based on the site and type of dilatation. Type I is most common.
Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.
Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.
A MAMMAGLOBIN A-related secretoglobin that is expressed in several HUMAN tissues including the UTERUS; BREAST; SALIVARY GLAND; and LACRIMAL GLAND.
Surgical formation of an opening through the ABDOMINAL WALL into the JEJUNUM, usually for enteral hyperalimentation.
Diseases of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Pathological processes of the PANCREAS.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
The duct that is connected to the GALLBLADDER and allows the emptying of bile into the COMMON BILE DUCT.
The duct which coveys URINE from the pelvis of the KIDNEY through the URETERS, BLADDER, and URETHRA.
Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
A country spanning from central Asia to the Pacific Ocean.
Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.
Tumors or cancer of the DIGESTIVE SYSTEM.
Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts.
Incision of Oddi's sphincter or Vater's ampulla performed by inserting a sphincterotome through an endoscope (DUODENOSCOPE) often following retrograde cholangiography (CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE). Endoscopic treatment by sphincterotomy is the preferred method of treatment for patients with retained or recurrent bile duct stones post-cholecystectomy, and for poor-surgical-risk patients that have the gallbladder still present.
Pathological processes of the LIVER.
Hemorrhage in or through the BILIARY TRACT due to trauma, inflammation, CHOLELITHIASIS, vascular disease, or neoplasms.
Antagonist of urate oxidase.
Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.
The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.
Presence or formation of GALLSTONES in the COMMON BILE DUCT.
An absorbable suture material used also as ligating clips, as pins for internal fixation of broken bones, and as ligament reinforcement for surgically managed ligament injuries. Its promising characteristics are elasticity, complete biodegradability, and lack of side effects such as infections.
A nontoxic radiopharmaceutical that is used in RADIONUCLIDE IMAGING for the clinical evaluation of hepatobiliary disorders in humans.
A Y-shaped surgical anastomosis of any part of the digestive system which includes the small intestine as the eventual drainage site.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
The transference of a part of or an entire liver from one human or animal to another.
Tumors or cancer of the LIVER.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A malignant epithelial tumor with a glandular organization.
Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
Sterile collagen strands obtained from healthy mammals. They are used as absorbable surgical ligatures and are frequently impregnated with chromium or silver for increased strength. They tend to cause tissue reaction.
Excision of the gallbladder through an abdominal incision using a laparoscope.
Antimetabolites that are useful in cancer chemotherapy.
A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.
Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
A motility disorder characterized by biliary COLIC, absence of GALLSTONES, and an abnormal GALLBLADDER ejection fraction. It is caused by gallbladder dyskinesia and/or SPHINCTER OF ODDI DYSFUNCTION.
Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.
Endoscopic examination, therapy or surgery of the digestive tract.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A structurally-related family of small, multimeric proteins that are secreted in the mucosa of mammalian epithelial tissues. A variety of proteins are classed under this heading including some secretoglobin subtypes that appear unique to a particular mammalian species, and others whose functions differ between species.
Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.
Vomiting caused by expectation of discomfort or unpleasantness.
A claudin subtype that takes part in maintaining the barrier-forming property of TIGHT JUNCTIONS. Claudin-4 is found associated with CLAUDIN-8 in the KIDNEY COLLECTING DUCT where it may play a role in paracellular chloride ion reabsorption.
Elements of limited time intervals, contributing to particular results or situations.
Surgery of the smooth muscle sphincter of the hepatopancreatic ampulla to relieve blocked biliary or pancreatic ducts.
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Disease having a short and relatively severe course.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.
A species of helminth commonly called the sheep liver fluke. It occurs in the biliary passages, liver, and gallbladder during various stages of development. Snails and aquatic vegetation are the intermediate hosts. Occasionally seen in man, it is most common in sheep and cattle.
A cyclin subtype that is found as a component of a heterotrimeric complex containing cyclin-dependent kinase 7 and CDK-activating kinase assembly factor. The complex plays a role in cellular proliferation by phosphorylating several CYCLIN DEPENDENT KINASES at specific regulatory threonine sites.
The condition of an anatomical structure's being dilated beyond normal dimensions.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A bile pigment that is a degradation product of HEME.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

New perspectives on biliary atresia. (1/473)

An investigation into the aetiology, diagnosis, and treatment of biliary atresia was carried out because the prognosis remains so poor.In an electron microscopical study no viral particles or viral inclusion bodies were seen, nor were any specific ultrastructural features observed. An animal experiment suggested that obstruction within the biliary tract of newborn rabbits could be produced by maternal intravenous injection of the bile acid lithocholic acid.A simple and atraumatic method of diagnosis was developed using(99) (m)Tc-labelled compounds which are excreted into bile. Two compounds, (99m)Tc-pyridoxylidene glutamate ((99m)Tc-PG) and (99m)Tc-dihydrothioctic acid ((99m)Tc-DHT) were first assessed in normal piglets and piglets with complete biliary obstruction. Intestinal imaging correlated with biliary tract patency, and the same correlation was found in jaundiced human adults, in whom the (99m)Tc-PG scan correctly determined biliary patency in 21 out of 24 cases. The (99m)Tc-PG scan compared well with liver biopsy and (131)I-Rose Bengal in the diagnosis of 11 infants with prolonged jaundice.A model of extrahepatic biliary atresia was developed in the newborn piglet so that different methods of bile drainage could be assessed. Priorities in biliary atresia lie in a better understanding of the aetiology and early diagnosis rather than in devising new bile drainage procedures.  (+info)

Casts of hepatic blood vessels: a comparison of the microcirculation of the penguin, Pygoscelis adeliae, with some common laboratory animals. (2/473)

Latex casts of the hepatic blood vessels of the penguin, Pygoscelis adeliae, and of some common laboratory animals were compared. There was general similarity between the different species, but the portal venous and hepatic arterial systems of the penguin were simpler than those of other species. Measurements were made of the volume and length of portal veins and it appears that the portal venous system is capable of being a more efficient blood reservoir in the penguin than in other species studied. The peribiliary plexus was especially well formed in the penguin and was drained by long veins which usually joined portal venous branches. Some of the long veins drained directly into the hepatic venous tree: these translobular veins were more prominent than in mammals. Anastomoses between hepatic artery and portal vein were not present in penguins, and the supply to the sinusoids appeared to be separate. The morphology of small hepatic veins of all the species appeared to be similar.  (+info)

Metabolism and disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) in rhesus monkeys. (3/473)

Metabolism and disposition of the tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent rodent lung carcinogen, were studied in rhesus monkeys. In three males receiving a single i.v. dose of [5-3H]NNK (0.72 mCi; 4.6-9.8 microg/kg), urine was collected for 10 days. Within the first 24 h, 86.0 +/- 0.7% of the dose was excreted. NNK-derived radioactivity was still detectable in urine 10 days after dosing (total excretion, 92.7 +/- 0.7%). Decay of urinary radioactivity was biexponential with half-lives of 1.7 and 42 h. Metabolite patterns in urine from the first 6 h closely resembled those reported previously for patas monkeys; end products of metabolic NNK activation represented more than 50% of total radioactivity. At later time points, the pattern shifted in favor of NNK detoxification products (60-70% of total radioactivity in urine), mainly 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its O-glucuronide conjugates. One female rhesus monkey received a single i.v. dose of [5-3H]NNK (1.72 mCi; 28.4 microg/kg) under isoflurane anesthesia; biliary excretion over 6 h (0.6% of the dose) was 10 times less than predicted by our previously reported rat model. No preferential excretion of NNAL glucuronide was observed in monkey bile. Collectively, these results suggest that the rhesus monkey could be a useful model for NNK metabolism and disposition in humans.  (+info)

Review article: antibiotic prophylaxis for endoscopic retrograde cholangiopancreatography (ERCP). (4/473)

This review examines the evidence for antibiotic prophylaxis in endoscopic retrograde cholangiopan-creatography (ERCP), and provides detailed advice about suitable antibiotic regimens in appropriate high-risk patients. Ascending cholangitis and infective endocarditis are potential complications of endoscopic ERCP. The pathophysiology of these two complications is quite separate and different sub-groups of patients require prophylaxis with appropriate antibiotic regimens. Ascending cholangitis results from bacterial infection of an obstructed biliary system, usually from enteric Gram-negative microorganisms, resulting in bacteraemia. There is incomplete drainage of the biliary system after ERCP in up to 10% of patients who require stenting. Antibiotics started in these patients will probably reduce the frequency of cholangitis by 80%. If antibiotics are restricted to this group, approximately 90% of all patients having an ERCP will avoid antibiotics, but 80% of cholangitic episodes will be prevented. Infective endocarditis may result from the bacteraemia caused at the time of the ERCP in patients with an abnormal heart valve. Antibiotic prophylaxis, in particular covering alpha-haemolytic streptococci, should be started before the procedure in this defined high-risk group.  (+info)

Enterogastric reflux mimicking gallbladder disease: detection, quantitation and potential significance. (5/473)

OBJECTIVE: Visualization of enterogastric reflux (EGR) may be present during hepatobiliary imaging. Reflux of bile may damage the gastric mucosa, altering its function, and cause such symptoms as epigastric pain, heartburn, nausea, intermittent vomiting and abdominal fullness. These symptoms also are associated with gallbladder disease. The aim of this study was to quantitate the EGR index (EGRI) and to determine if a difference exists in normal and abnormal responses using standard cholecystokinin (CCK)-augmented hepatobiliary imaging. METHODS: This study used 129 patients. LAO dynamic data on a 128 x 128 matrix at a rate of 1 frame/min were obtained. After the gallbladder ejection fraction (GBEF) was determined, the EGRI (%) was calculated by relating the counts in the gastric ROI to the counts in the hepatobiliary ROI at a specified time. The results were compared with the patient's final clinical diagnosis. RESULTS: Normal responders (GBEF > or = 35%) had a higher EGRI than abnormal responders with a P = 0.001 EGR observed in 75 patients (58.1%). Significant reflux (EGRI > or = 14.2% at 15 min) was observed in 29 additional patients (22.5%). Patients with EGRI > or = 24.5% showed a strong association with the pathophysiologic syndrome of gastritis, alkaline reflux, gastric ulcer and gastro esophageal reflux disease. There was no EGR observed in the remaining 25 patients (19.4%). CONCLUSION: This simple addition to the CCK-augmented hepatobiliary imaging may both detect and quantitate abnormal EGR as the cause of the patient's symptoms in the presence of a normal GBEF result, and/or those patients with risk factors for gastritis.  (+info)

The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids. (6/473)

Class III P-glycoproteins (Pgps) mediate biliary phosphatidylcholine (PC) secretion. Recent findings that class I P-glycoproteins are able to transport several short-chain phospholipid analogues raises questions about the role of these Pgps in physiological lipid transport. We investigated the biliary secretion of C6-7-nitro-2,1, 3-benzoxadiazol-4-yl (NBD)-labeled ceramide and its metabolites in Mdr1a/b and Mdr2 knockout mice compared to control mice. Biliary secretion of these NBD-lipids was unaffected in Mdr1a/b -/- mice. Thus neither Mdr1a nor Mdr1b Pgp mediates biliary secretion of these lipids. In contrast, secretion of all three NBD-labeled short-chain phospholipids was significantly reduced in Mdr2 -/- mice. As in vitro studies revealed that Mdr2 Pgp is not able to translocate these lipid analogues, we hypothesized that Mdr2 -/- mice had a reduced PC content of the exoplasmic canalicular membrane leaflet so that extraction of the short-chain lipid probes from this membrane by canalicular bile salts was impaired. To investigate this possibility we studied the bile salt-mediated extraction of natural sphingomyelin (SM) and NBD-labeled short-chain SM from small unilamellar vesicles of different lipid composition. Natural SM could be extracted by the bile salt tauroursodeoxycholate from vesicles containing PC, cholesterol (CHOL), and SM (1:2:2) but not from vesicles containing only SM and CHOL (3:2). NBD-labeled short-chain SM could be extracted from vesicles containing PC while its extraction from pure SM:CHOL vesicles was reduced by 65%. These data confirm that the efficiency of NBD-SM extraction depends on the lipid composition and suggest that the canalicular membrane outer leaflet of Mdr2 -/- mice has a reduced PC content.  (+info)

Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle. (7/473)

Elevated cholesterol decreases agonist-induced contractility and enhances stone formation in the gallbladder. The current study was conducted to determine if and how the electrical properties and ionic conductances of gallbladder smooth muscle are altered by elevated cholesterol. Cholesterol was delivered as a complex with cyclodextrin, and effects were evaluated with intracellular recordings from intact gallbladder and whole cell patch-clamp recordings from isolated cells. Cholesterol significantly attenuated the spontaneous action potentials of intact tissue. Furthermore, calcium-dependent action potentials and calcium currents were reduced in the intact tissue and in isolated cells, respectively. However, neither membrane potential hyperpolarizations induced by the ATP-sensitive potassium channel opener, pinacidil, nor voltage-activated outward potassium currents were affected by cholesterol. Hyperpolarizations elicited by calcitonin gene-related peptide were reduced by cholesterol enrichment, indicating potential changes in receptor ligand binding and/or second messenger interactions. These data indicate that excess cholesterol can contribute to gallbladder stasis by affecting calcium channel activity, whereas potassium channels remained unaffected. In addition, cholesterol enrichment may also modulate receptor ligand behavior and/or second messenger interactions.  (+info)

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats. (8/473)

In rats and mice, 1-nitronaphthalene (1-NN) produces both lung and liver toxicity. Even though these toxicities have been reported, the metabolism and disposition of 1-NN have not been elucidated. Therefore, studies were performed to characterize its fate after i.p. and i.v. administration to male Sprague-Dawley rats. After i.p. administration of [(14)C]1-NN (100 mg/kg; 60 microCi/kg), 84% of the dose was eliminated in the urine and feces by 48 h. At 96 h, 60% of the dose was recovered in the urine, 32% in the feces, and 1% collectively in the tissues, blood, and gastrointestinal contents. The terminal phase rate constant (k(term)) of 1-NN was 0.21 h(-1), the terminal phase half-life (T(1/2,term)) was 3.40 h, and the systemic bioavailability was 0.67. When administered i.v. (10 mg/kg; 120 microCi/kg), 85% of the dose was eliminated in the urine and feces by 24 h. At the end of the study (96 h), 56% of the dose was recovered in the urine, 36% in the feces, and 1% collectively in the tissues, blood, and gastrointestinal contents. Interestingly, 88% of the dose was secreted into bile by 8 h. The k(term) was 0.94 h(-1) and the T(1/2,term) was 0.77 h. The major urinary metabolite after both routes of administration was N-acetyl-S-(hydroxy-1-nitro-dihydronaphthalene)-L-cysteine. Other urinary metabolites identified include hydroxylated, dihydroxylated, glucuronidated, sulfated, and reduced metabolites, as well as dihydrodiol. The major biliary metabolite was hydroxy-glutathionyl-1-nitro-dihydronaphthalene. These data show that 1-NN undergoes extensive metabolism and enterohepatic recirculation, and the majority of the dose is eliminated in the urine.  (+info)

Recent advances in imaging techniques have determined a radical change in the radiological approach to the diagnosis and treatment of hepatobiliary, pancreatic, and.Diagnostic imaging of the hepatobiliary system in infants and children.Diagnostic Imaging of the Hepatobiliary System An Update Angela J.Applied hepatobiliary scintigraphy in. multiple imaging tests are used in what often. while displaying the least activity outside the hepatobiliary system.Gastrointestinal and Hepatobiliary Imaging PIONEERS OF AIIMS-MAMC-PGI IMAGING COURSE SERIES Manorama Berry Sudha Suri.. Imaging is a big part of the workup for evaluating liver cancer ...
Looking for biliary system? Find out information about biliary system. The complex of canaliculi, or microscopic bile ducts, that empty into the larger intrahepatic bile ducts Explanation of biliary system
Others檢查 健康生活易與Mobile Medical Group「MM+」合作提供MM+ Standard Health Check (focus on Hepatobiliary System),詳情 MM+ provides one-stop comprehensive  and quality medical services. We offer a patient-centric healthcare journey with comprehensive, high-quality, caring services. Our centre offers an exclusive VIP waiting room for VIP customers who prefer more privacy. It also provides an area for clients to enjoy snacks or drinks after their check-up.   This standard plan includes standard items that a body health check should have, but focus heavily on screening the health condition of the organ HEPATOBILIARY SYSTEM.
AbstractAs therapeutic antisense tools, oligonucleotides (ODNs) must enter cells to bind to their target structures. ODNs distribute in nearly each tissue with relatively high concentrations in kidney and liver from where excretion into urine and bile occurs. To investigate mechanisms involved in he
note that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ...
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The gastrointestinal exam is used to assess patients for pathology affecting the gastrointestinal tract, hepatobiliary system or other abdominal organs.
However, some doctors may want to have incorporation of the pharmacogenomic data into the EMR. This would be quite handy. Using me as an example, if I ever get depression, I would let the doctor know the SSRIs above and the fact that I may, with these meds, require more of the usual dose and sooner. Additionally, I can see there the health maintenance reminder for a patient with LYNCH SYNDROME, for instance would be important. Individuals with Lynch syndrome have an increased risk of colorectal and endometrial cancer [1]. Other sites of cancer include the ovary, stomach, small bowel, hepatobiliary system, renal pelvis, ureter, brain, and skin. There may also be an increased risk of breast, prostate, and pancreatic cancer in individuals with Lynch syndrome. Just using the colorectal cancer screening recommendations (UpToDate): Individuals with Lynch syndrome should undergo colorectal cancer (CRC) screening with colonoscopy every one to two years beginning at age 20 to 25 years, or two to five ...
n of your full length CFTR cDNA. To investigate if any portion of the CFTR cDNA was being unintentionally expressed as a result of the presence of a cryptic
Large search returns make our pages slow to load. Therefore, some functionality has been disabled until you refine your search to bring the number of returned assay results under TBD ...
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Consistent with previous reports, the biliary excretion of acetaminophen glucuronide and acetaminophen glutathione was negligible in livers from Mrp2-deficient rats (Xiong et al., 2000; Chen et al., 2003). In contrast, the biliary excretion of AS was maintained partially in the absence of Mrp2. Recent reports suggested that BCRP, a transporter localized to the canalicular membrane in hepatocytes, may be capable of transporting sulfate conjugates (Maliepaard et al., 2001; Imai et al., 2003; Suzuki et al., 2003). To evaluate the potential contribution of Bcrp1 to biliary excretion of AS, acetaminophen disposition was studied in IPLs from wild-type Wistar and Mrp2-deficient TR- rats in the presence or absence of the Bcrp1 and P-glycoprotein inhibitor, GF120918.. GF120918 is an inhibitor of both P-glycoprotein and Bcrp1, but not Mrp2 (de Bruin et al., 1999; Evers et al., 2000; Shepard et al., 2003). This modulator has been used previously in recirculating IPLs to impair (∼10-fold) biliary ...
We offer expert care in medical & surgical gastroenterology and focuses on treatment of digestive tract, liver & pancreatic diseases in children and adults.
Mycophenolic acid (MPA) is part of the immunosuppressant therapy for transplant recipients. This study examines the role of the canalicular transporter, Mrp2, and the effect of cyclosporin A (CsA), on the biliary secretion of the ether (MPAGe) and acyl (MPAGa) glucuronides of MPA. Isolated livers from Wistar rats (n = 6), or Wistar TR- rats (n = 6) were perfused with MPA (5 mg/l). A third group of Wistar rats (n = 6) was perfused with MPA and CsA (250 μg/l). There was no difference in the half-life, hepatic extraction ratio (EH), clearance or partial clearance of MPA to MPAGe, but there was a difference in partial clearance to MPAGa between control and CsA groups (0.9 ± 0.4 versus 0.5 ± 0.1 ml/min). TR- rats had a lower EH (0.59 ± 0.30 versus 0.95 ± 0.30), a lower clearance (18 ± 8 versus 29 ± 7 ml/min), and a longer half-life (19.5 ± 10.3 versus 10.1 ± 2.4 min) than controls. Compared to controls, MPAGe and MPAGa biliary excretion was reduced by 99% and 71.8%, respectively, in TR- ...
Ebook `Diseases of the liver, gall bladder, and biliary system; their pathology, diagnosis, and surgical treatment`: ebooks list of Holburt Jacob Waring
Fenestra® VC is a refined version of Fenestra® LC in which the surface of the lipid emulsion particles is modified so as to alter the recognition of the particle by the receptors on hepatocytes that are responsible for its uptake into the liver. With Fenestra VC, the delayed uptake by liver cells produces an agent with superior blood pool imaging properties that last for several hours after injection. Moreover, the agent remains truly intravascular so long as the endothelial integrity of the vessel is maintained. Like its liver-selective counterpart, Fenestra VC is eventually metabolized and eliminated through the hepatobiliary system.. Because of their comparatively long and stable in vivo residence times (up to several hours), the Fenestra® products have shown considerable promise for use in microCT imaging procedures. The numerous benefits provided by the Fenestra technology will play an instrumental role in facilitating the implementation of microCT imaging as an increasingly important ...
ICD-10-PCS code 0FQG3ZZ for Repair Pancreas, Percutaneous Approach is a medical classification as listed by CMS under Hepatobiliary System and Pancreas range.
The Institutes of Gastroenterology are dedicated to the management of diseases of the digestive and hepatobiliary systems in children and adults. The Institutes offer expert care in both Medical and Surgical Gastroenterology.
Detailed information on the most common disorders of the biliary system, including gallstones, cholangitis, cholecystitis, biliary cirrhosis, and biliary duct cancer
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Surgery of the liver, pancreas and biliary system HPB stands for Hepato-Pancreato-Biliary surgery. Gallstones and gallbladder surgery.
Posts Tagged With And Biliary System varian cyst symptom checkerh4 other hand if the sphincter of Oddi is a digestion bloating IBS
C.O. Mills, R.G.P. Watson, S. Chandler, J. Trifunovic, E. Elias; Assessment of 123I-Cholylglycyltyrosine and 99MTC-Iodida as Hepatobiliary Imaging Agents in Jaundiced Patients. Clin Sci (Lond) 1 January 1988; 75 (s19): 8P-9P. doi: https://doi.org/10.1042/cs075008Pc. Download citation file:. ...
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ERCP and PTHC allow for direct imaging of the biliary ducts. MRCP is a non-invasive alternative for imaging the biliary system ...
A team of specialist doctors from London provides patients and their carers with information about surgery of the liver, pancreas and biliary system that may help them understand their illness better and make the correct decisions. ...
Surgeons at the Burlingame Center offer expertise in the treatment of benign & malignant diseases of the liver, biliary system, & pancreas.
Clay-colored stools or pale stools once may be nothing, but seeing them often can be a sign of a problem in the biliary system. What should you do?
In the present study, a variety of techniques were used to investigate the effects of Ca2+ depletion on the transport properties and tight junctions of hepatocytes cultured in a sandwich configuration. The results indicate that: 1) Ca2+ depletion does not alter taurocholate transport; 2) Ca2+ depletion increases the permeability of tight junctions, thus disrupting the barrier between the canalicular lumen and the extracellular space; 3) integrity of the disrupted tight junctions cannot be re-established completely by incubation in the presence of Ca2+ for 1 h; and 4) taurocholate accumulation involves Michaelis-Menten nonlinear processes for uptake and biliary excretion.. Hepatocytes cultured in a collagen-sandwich configuration for 6 days form complete junctional complexes composed of a tight junction, intermediate junction, and desmosomes (LeCluyse et al., 1994). Recently, Talamini et al. (1997) demonstrated the existence of junctional protein, uvomorulin (E-cadherin), in hepatocytes cultured ...
O:13:\PanistOpenUrl\:36:{s:10:\\u0000*\u0000openUrl\;N;s:6:\\u0000*\u0000idc\;N;s:6:\\u0000*\u0000fmt\;s:7:\journal\;s:6:\\u0000*\u0000doi\;s:0:\\;s:6:\\u0000*\u0000pii\;s:0:\\;s:7:\\u0000*\u0000pmid\;s:0:\\;s:9:\\u0000*\u0000atitle\;s:114:\A DEMONSTRATION OF MICROWILL ON THE LUMINAL SURFACES OF EPITHELIAL CELLS OF THE CANINE EXTRAHEPATIC BILIARY TRACT.\;s:9:\\u0000*\u0000jtitle\;s:0:\\;s:9:\\u0000*\u0000stitle\;s:0:\\;s:7:\\u0000*\u0000date\;s:4:\1975\;s:9:\\u0000*\u0000volume\;s:0:\\;s:8:\\u0000*\u0000issue\;s:0:\\;s:8:\\u0000*\u0000spage\;s:0:\\;s:8:\\u0000*\u0000epage\;s:0:\\;s:8:\\u0000*\u0000pages\;s:0:\\;s:7:\\u0000*\u0000issn\;s:0:\\;s:8:\\u0000*\u0000eissn\;s:0:\\;s:9:\\u0000*\u0000aulast\;s:5:\TANSY\;s:10:\\u0000*\u0000aufirst\;s:2:\MF\;s:9:\\u0000*\u0000auinit\;N;s:10:\\u0000*\u0000auinitm\;N;s:5:\\u0000*\u0000au\;a:5:{i:0;s:8:\TANSY MF\;i:1;s:9:\SALKIN LM\;i:2;s:10:\KENDALL FM\;i:3;s:8:\INNES ...
TY - JOUR. T1 - Systemic and local release of inflammatory cytokines regulates hepatobiliary excretion of 99mTc-mebrofenin. AU - Joseph, Brigid. AU - Bhargava, Kuldeep K.. AU - Tronco, Gene G.. AU - Palestro, Christopher J.. AU - Gupta, Sanjeev. PY - 2008/4. Y1 - 2008/4. N2 - Imaging agents capable of providing cell compartment-specific information will facilitate studies of pathophysiological mechanisms, natural history of diseases, and therapeutic development. To demonstrate the effects of liver injury on the disposal of the organic anion mebrofenin, we performed animal studies.. AB - Imaging agents capable of providing cell compartment-specific information will facilitate studies of pathophysiological mechanisms, natural history of diseases, and therapeutic development. To demonstrate the effects of liver injury on the disposal of the organic anion mebrofenin, we performed animal studies.. KW - Cytokine. KW - Inflammation. KW - Liver. KW - Mebrofenin. KW - Transport. UR - ...
The biliary tract refers to the path by which bile is secreted by the liver then transported to the duodenum, the first part of the small intestine. A structure common to most members of the mammal family, the biliary tract is often referred to as a tree because it begins with many small branches which end in the common bile duct, sometimes referred to as the trunk of the biliary tree. The duct, the branches of the hepatic artery, and the portal vein form the central axis of the portal triad. Bile flows in the direction opposite to that of the blood present in the other two channels. The system is usually referred to as the biliary tract or system, [2]and can include the use of the term hepatobiliary when used to refer just to the liver and bile ducts.[3] The name biliary tract is used to refer to all of the ducts, structures and organs involved in the production, storage and secretion of bile.[4] The tract is as follows: ...
Journal: EJNMMI Research ArticleTitle: Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients
TY - JOUR. T1 - Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl- Transport in biliary epithelial cells through a PKCζ-dependent pathway. AU - Woo, Kangmee. AU - Dutta, Amal K.. AU - Patel, Vishal. AU - Kresge, Charles. AU - Feranchak, Andrew P.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2008/6/1. Y1 - 2008/6/1. N2 - ATP in bile is a potent secretogogue, stimulating cholangiocyte Cl- and fluid secretion via binding to membrane P2 receptors, though the physiological stimuli involved in biliary ATP release are unknown. The goal of the present studies was to determine the potential role of fluid flow in biliary ATP release and secretion. In both human Mz-Cha-1 biliary cells and normal rat cholangiocyte monolayers, exposure to flow increased relative ATP release which was proportional to the shear stress. In parallel studies, shear was associated with an increase in [Ca2+]i and membrane Cl- permeability, which were both dependent on ...
Damage of the biliary tract at the end of a period of hepatic preservation prior to liver transplantation has been observed in man. This damage may be important in the development of early biliary complications. A model of hepatic biliary ischaemia in the pig has been developed which permits comparison between the influences of warm and cold ischaemic damage on the biliary tract. The major damage to the biliary tract in the pig in this model appears to occur after prolonged cold preservation.
The molecular pathogenesis of biliary tract cancers is poorly understood. By performing immunohistochemical analysis of more than 125 surgically resected cases of biliary tract carcinoma, we have previously shown altered cell cycle regulatory protein expression in biliary tact cancers [13]. Our current findings also show mutated expression of a large number of cell cycle regulators including UBD, BCL2L2, CDC2, MCM2, and CDKN1C in all subtypes. Similarly, Kang et al. [15] found that expression of G1-S modulators were commonly mutated in 42 cases of IHC. Total loss of p16, p27, and Rb were detected at rates of in 36%, 31%, 12%, respectively, in cancer specimens. Furthermore, in the above study, even in 7 of 13 cases of biliary dysplasia, without frank carcinoma, abnormal expression of p53, cyclin D1 or p16 was detected. Kim et al. [16] reported that the mutation of the p53, p16, and K-ras genes occurred at rates of 36%, 31% and 20%, respectively, in GBC. A further finding of the above study was ...
Outcomes of vaginal reconstructive surgery with and without graft material. The incidence of urinary tract injury during hysterectomy: A prospective analysis based on universal cystoscopy
HZI-Scientists have elucidated which bacteria block artificial bile ducts.  A consequence of the different cancers of the hepatobiliary system is blocked bile ducts. However, artificial catheters known as stents can remediate this problem. Stents …
The aim of this non-investigational study is to determine the symptoms and burden at the moment of diagnosis and in the further course of an incurable cancer disease. The needs and preferences of patients suffering from cancer (ovarian carcinoma, breast cancer, malignant melanoma, lung cancer, stomach cancer, oesophageal cancer, pancreatic cancer, cancer of the hepatobiliary system, colorectal cancer, head and neck cancer) will be examined by various questionnaires. The data obtained by these questionnaires will be collected together with information obtained by the treating physicians at four time points during the study: T0 - patient´s enrollment, at the moment of diagnosis and before the start of tumor therapy, respectively; T1 - 3 months after the patient´s enrollment; T2 - 6 months after the patient´s enrollment; T3 - 12 months after the patient´s enrollment. This highly innovative project offers the chance to identify medical services deficits and risk circumstances for the burden of ...
When human (cryopreserved) hepatocytes are used to establish sandwich cultures, the model appears particularly valuable to quantitatively investigate clinically relevant mechanisms related to in vivo hepatobiliary drug disposition and hepatotoxicity. Nonetheless, the SCH model would largely benefit …
Zhumadilov, Z.S., Skuba, N.D. & Makarenkova, R.V. Experimental study of oriented antibiotic transport in suppurrtive-inflammatory diseases of the liver and biliary tract. Bull Exp Biol Med 109, 592-596 (1990). https://doi.org/10.1007/BF00839875. Download ...
Why do you need an MRI of the liver and biliary tract and where to do it. Indications and contraindications for the study. Preparation for magnetic resonance imaging.
Fingerprint Dive into the research topics of 23-methyl-3α,7β-dihyroxy-5β-cholan-24-oic acid: Dose-response study of biliary secretion in rat. Together they form a unique fingerprint. ...
ဝမ္းဗိုက္နာျခင္း၊ေအာင့္ျခင္းသည္ ဂတ္စ္ သို႔ အစာမေၾကျခင္း ေၾကာင့္ ျဖစ္တတ္ေသာ ပံုမွန္ျဖစ္ရိုးျဖစ္စဥ္တစ္ခုျဖစ္နိုင္ပါတယ္။ သို႔ေသာ္လည္း ရိုးရိုးနာျခ
Life gives us plenty of reasons to feel good, but at the same time we have to say honestly: to be an adult in the modern world can be a pretty stressful. Whether if you are a student during exams, m ...
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My BEC score was 74. Im disappointed, but I am not down and will retake the test in a month.bUnfortunately, now I have to get comfortable with a new ...
Albany, US) DelveInsight has launched a new report on Biliary Tract Cancers Market. DelveInsights Biliary Tract Cancers (BTCs) - Market Insights, Epidemiology, and Market Forecast-2030 report delivers an in-depth understanding of the Biliary Tract Cancers (BTCs), historical and forecasted epidemiology as well as the Biliary Tract Cancers (BTCs) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. The Biliary Tract Cancers (BTCs) market report provides current treatment practices, emerging drugs, Biliary Tract Cancers (BTCs) market share of the individual therapies, current and forecasted Biliary Tract Cancers (BTCs) market Size from 2017 to 2030 segmented by seven major markets. The Report also covers current Biliary Tract Cancers (BTCs) treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market.. Biliary Tract Cancer (BTC), also ...
Biliary-enteric anastomosis (BEA) is a common surgical procedure performed for the management of biliary obstruction or leakage that results from a variety of benign and malignant diseases. Complications following BEA are not rare. We aimed to determine the incidence and the factors associated with early complications occurring after BEA for benign diseases. We reviewed the medical records of all patients who underwent BEA for benign diseases at our institution between January 1988 and December 2009. The primary outcome was early post operative complication. Logistic regression analysis was done to identify factors predicting the occurrence of complications. Records of 79 patients were reviewed. There were 34 (43%) males and 45 (57% females). Majority (53%) had choledocholithiasis with impacted stone or distal stricture, followed by traumatic injury to the biliary system (33%). Thirty-four patients (43%) underwent a hepaticojejunostomy, 19 patients (24%) underwent a choledochojejunostomy, and
[Biliary tract cyst after Kasai portoenterostomy in extrahepatic biliary tract atresia and its relationship with repeated cholangitis].:
The biliary tract, (biliary tree or biliary system) refers to the liver, gall bladder and bile ducts, and how they work together to make, store and secrete bile. Bile consists of water, electrolytes, bile acids, cholesterol, phospholipids and conjugated bilirubin. Some components are synthesised by hepatocytes (liver cells), the rest are extracted from the blood by the liver. Bile is secreted by the liver into small ducts that join to form the common hepatic duct. Between meals, secreted bile is stored in the gall bladder. During a meal, the bile is secreted into the duodenum to rid the body of waste stored in the bile as well as aid in the absorption of dietary fats and oils. The biliary tract refers to the path by which bile is secreted by the liver then transported to the duodenum, the first part of the small intestine. A structure common to most members of the mammal family, the biliary tract is often referred to as a tree because it begins with many small branches which end in the common ...
TY - JOUR. T1 - Multiple anaerobic hepatic abscesses demonstrated on hepatobiliary scintigraphy. AU - Moreno, A. J.. AU - Battafarano, N. J.. AU - Nelson, P. M.. AU - Rhea, E.. AU - Parker, A. L.. PY - 1986/1/1. Y1 - 1986/1/1. UR - http://www.scopus.com/inward/record.url?scp=0022623261&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0022623261&partnerID=8YFLogxK. U2 - 10.1097/00003072-198603000-00017. DO - 10.1097/00003072-198603000-00017. M3 - Article. C2 - 3956029. AN - SCOPUS:0022623261. VL - 11. SP - 204. EP - 205. JO - Clinical Nuclear Medicine. JF - Clinical Nuclear Medicine. SN - 0363-9762. IS - 3. ER - ...
(HealthDay) -- For patients with biliary tract cancers, postresection adjuvant therapy with chemotherapy or chemoradiotherapy appears to be beneficial in treating patients with biliary tract cancers, with significant improvement ...
Section 2. Liver and Biliary Tract Disease. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. Longo D.L., Fauci A.S., Kasper D.L., Hauser S.L., Jameson J, Loscalzo J Eds. Dan L. Longo, et al.eds. Harrisons Principles of Internal Medicine, 18e New York, NY: McGraw-Hill; 2012. http://accesspharmacy.mhmedical.com/content.aspx?bookid=331§ionid=40727095. Accessed February 19, 2018 ...
Semantic Scholar extracted view of D-glucitol in the treatment of biliary tract disease; preliminary observations. by N W CHAIKIN
Fig. 8. Jagged-mediated Notch signaling may regulate a binary cell-fate decision of zebrafish hepatoblasts. (A-F,I) Histological sections through the liver of 5-dpf wild-type (A-C) and jagged 2/3 morphant (D-F,I) larvae processed for cytokeratin and P-glycoprotein IHC. (A) A Branching network of bile ducts is evident in this wild-type larva. (B) Section in A processed for histology with superimposed pseudocolored cytokeratin pattern (magenta). (D) Four hepatocyte rosettes (arrows) are shown in this section through the liver of a jagged 2/3 morphant larva. Weak cytokeratin expression is also present in endothelial cells lining sinusoids seen in cross-section (arrowheads). (E) Section in D processed for histology with superimposed pseudocolored cytokeratin pattern (magenta). These sections show cytokeratin within the apical region of rosette cells (arrow indicates one of the four rosettes identified in D) and in surrounding sinusoidal endothelial cells (arrowhead). Dashed lines outline individual ...
A Tc-99m-labelled compound with the biological characteristics of flumazenil would be useful for determination of neuronal viability after the onset of a stroke. Therefore, we have derivatized Ro-15-3890 (a flumazenil metabolite bearing a carboxylic acid group instead of an ethyl ester) by coupling it with a bisamino bisthiol tetraligand bearing a 3-hydroxypropyl side chain (3-hydroxypropyl-BAT) to enable labelling with technetium-99m. After purification by RP-HPLC, the ligand was deprotected and labelled in a one pot reaction, yielding a Tc-99m-BAT-propylester of Ro-15-3890 (Tc-99m-techmazenil). Radio-LC-MS analysis of the isolated main peak showed the molecular ion mass (608.0618) of the expected Tc-99m-techmazenil. The biodistribution of Tc-99m-techmazenil was investigated in normal mice and indicated that the tracer is cleared from plasma mainly by the hepatobiliary system and shows a very low uptake in brain. In vitro binding studies on mice brain slices indicated that techmazenil does ...
Cystic fibrosis (CF) is a monogenic disorder with a complex phenotype and clinical variability. It is observed in approximately 1 in 2500 births among Caucasians, and has a carrier frequency of 1 in 25 individuals, making it the most common lethal monogenetic disease within this demographic group. CF is caused by mutations in a 180 kb gene localized to the long arm of chromosome 7. The gene encodes the 1480 amino acid cystic fibrosis transmembrane conductance regulator (CFTR) protein.. CF cases present with complex phenotypes and clinical variability. Defects in CFTR lead to altered exocrine secretion and pathological changes in multiple organ systems. Therefore, CF provides an excellent example of the ways in which a single gene defect confers a wide variety of clinical symptoms. The most commonly affected organs include the airways, gastrointestinal (GI) tract, pancreas, sweat glands, hepatobiliary system, and genital tract. The most life-threatening clinical features of CF are recurrent and ...
Theres no doubt Ive always wanted to; its been a combination of running low on ideas, and the taking over of my mind by the disignorable realities of politics, of our nation, our world. And it was easy: every day there are outrages aplenty, no end of blogfodder, as the evidence of devolution of our politics is everywhere. I suppose I got a few things out, decongested my hepatobiliary system. But really, it was the ever-truth that nothing I said on my other blog mattered. I always knew it. I dont know what led to the final recogniton that there was no point. Partly, I think, it was re-reading some posts over here, and the comments they engendered. Its not cold fusion, but I think it was useful, once in a while adding something to the common good, if only a tiny blip ...
Sixty fresh adult livers were obtained from cadavers together with celiac trunk, head of the pancreas and superior mesenteric artery. We have found a
Bioarray offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request ...
The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is more than 60 days but less than or equal to 180 days. The sponsor cannot require changes to the communication and cannot extend the embargo ...
hepatobiliary pancreatic twelve intestines section structural model of gastric gastroenterology medical whipple gasen xh001 в наличии / купить в один клик в нашем интернет- ...
At the Complex HPB Institute at Denver Health, our team provides comprehensive care for complex liver, pancreas and biliary tract diseases.
By sharing our collective experience through interesting patient cases, we can make a real difference in how people are imaged and diagnosed. Each case belongs to a contributing member, which can then be viewed and added to articles or playlists by the community, and is guided by dedicated editors to match quality standards and privacy needs. Upload new case ...
By sharing our collective experience through interesting patient cases, we can make a real difference in how people are imaged and diagnosed. Each case belongs to a contributing member, which can then be viewed and added to articles or playlists by the community, and is guided by dedicated editors to match quality standards and privacy needs. Upload new case ...

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