The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
Tumors or cancer of the BILE DUCTS.
Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.
Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).
Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
A malignant tumor arising from the epithelium of the BILE DUCTS.
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
Diseases of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of esophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (JAMA 1995;273(23):1824-30)
A benign tumor of the intrahepatic bile ducts.
An imaging test of the BILIARY TRACT in which a contrast dye (RADIOPAQUE MEDIA) is injected into the BILE DUCT and x-ray pictures are taken.
Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.
Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.
Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.
Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The BILE DUCTS and the GALLBLADDER.
The duct that is connected to the GALLBLADDER and allows the emptying of bile into the COMMON BILE DUCT.
Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).
Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.
Any surgical procedure performed on the biliary tract.
Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.
The largest lymphatic vessel that passes through the chest and drains into the SUBCLAVIAN VEIN.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Application of a ligature to tie a vessel or strangulate a part.
Excision of the gallbladder through an abdominal incision using a laparoscope.
Surgical removal of the GALLBLADDER.
A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Presence or formation of GALLSTONES in the COMMON BILE DUCT.
Incision of Oddi's sphincter or Vater's ampulla performed by inserting a sphincterotome through an endoscope (DUODENOSCOPE) often following retrograde cholangiography (CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE). Endoscopic treatment by sphincterotomy is the preferred method of treatment for patients with retained or recurrent bile duct stones post-cholecystectomy, and for poor-surgical-risk patients that have the gallbladder still present.
Minute intercellular channels that occur between liver cells and carry bile towards interlobar bile ducts. Also called bile capillaries.
Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
Tumors or cancer of the LIVER.
Any of the ducts which transport saliva. Salivary ducts include the parotid duct, the major and minor sublingual ducts, and the submandibular duct.
Excision of all or part of the liver. (Dorland, 28th ed)
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Pathological processes of the LIVER.
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.
A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.
Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
A congenital anatomic malformation of a bile duct, including cystic dilatation of the extrahepatic bile duct or the large intrahepatic bile duct. Classification is based on the site and type of dilatation. Type I is most common.
An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.
Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).
A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. In higher vertebrates, Wolffian ducts persist in the male forming VAS DEFERENS, but atrophy into vestigial structures in the female.
Surgical formation of an opening (stoma) into the COMMON BILE DUCT for drainage or for direct communication with a site in the small intestine, primarily the DUODENUM or JEJUNUM.
Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
A bile pigment that is a degradation product of HEME.
The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.
Tumors or cancer of the gallbladder.
Adenocarcinoma of the common hepatic duct bifurcation. These tumors are generally small, sharply localized, and seldom metastasizing. G. Klatskin's original review of 13 cases was published in 1965. Once thought to be relatively uncommon, tumors of the bifurcation of the bile duct now appear to comprise more than one-half of all bile duct cancers. (From Holland et al., Cancer Medicine, 3d ed, p1457)
The transference of a part of or an entire liver from one human or animal to another.
A pair of ducts near the WOLFFIAN DUCTS in a developing embryo. In the male embryo, they degenerate with the appearance of testicular ANTI-MULLERIAN HORMONE. In the absence of anti-mullerian hormone, mullerian ducts give rise to the female reproductive tract, including the OVIDUCTS; UTERUS; CERVIX; and VAGINA.
Veins which drain the liver.
Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.
The circulation of BLOOD through the LIVER.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
Surgical formation of an opening through the ABDOMINAL WALL into the JEJUNUM, usually for enteral hyperalimentation.
Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Congenital cystic dilatation of the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). It consists of 2 types: simple Caroli disease is characterized by bile duct dilatation (ectasia) alone; and complex Caroli disease is characterized by bile duct dilatation with extensive hepatic fibrosis and portal hypertension (HYPERTENSION, PORTAL). Benign renal tubular ectasia is associated with both types of Caroli disease.
The condition of an anatomical structure's being dilated beyond normal dimensions.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.
Surgical venous shunt between the portal and systemic circulation to effect decompression of the portal circulation. It is performed primarily in the treatment of bleeding esophageal varices resulting from portal hypertension. Types of shunt include portacaval, splenorenal, mesocaval, splenocaval, left gastric-caval (coronary-caval), portarenal, umbilicorenal, and umbilicocaval.
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)
The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.
A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.
A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A Y-shaped surgical anastomosis of any part of the digestive system which includes the small intestine as the eventual drainage site.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
The destruction of a calculus of the kidney, ureter, bladder, or gallbladder by physical forces, including crushing with a lithotriptor through a catheter. Focused percutaneous ultrasound and focused hydraulic shock waves may be used without surgery. Lithotripsy does not include the dissolving of stones by acids or litholysis. Lithotripsy by laser is LITHOTRIPSY, LASER.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Instruments for the visual examination of interior structures of the body. There are rigid endoscopes and flexible fiberoptic endoscopes for various types of viewing in ENDOSCOPY.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A tubular duct that conveys TEARS from the LACRIMAL GLAND to the nose.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.
A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon.
Paired ducts in the human male through which semen is ejaculated into the urethra.
An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.
A radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4)
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Surgery of the smooth muscle sphincter of the hepatopancreatic ampulla to relieve blocked biliary or pancreatic ducts.
The venous pressure measured in the PORTAL VEIN.
INFLAMMATION of the LIVER.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Examination of the portal circulation by the use of X-ray films after injection of radiopaque material.
The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.
Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.
Elements of limited time intervals, contributing to particular results or situations.
The act of dilating.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Accumulation or retention of free fluid within the peritoneal cavity.
Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Recycling through liver by excretion in bile, reabsorption from intestines (INTESTINAL REABSORPTION) into portal circulation, passage back into liver, and re-excretion in bile.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Pathological processes of the PANCREAS.
A subclass of ORGANIC ANION TRANSPORTERS whose transport of organic anions is driven either directly or indirectly by a gradient of sodium ions.
Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Endoscopic examination, therapy or surgery of the digestive tract.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Fragmentation of CALCULI, notably urinary or biliary, by LASER.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
A species of trematode flukes of the family Opisthorchidae. Many authorities consider this genus belonging to Opisthorchis. It is common in China and other Asiatic countries. Snails and fish are the intermediate hosts.
The narrow tube connecting the YOLK SAC with the midgut of the EMBRYO; persistence of all or part of it in post-fetal life produces abnormalities, of which the commonest is MECKEL DIVERTICULUM.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A nontoxic radiopharmaceutical that is used in RADIONUCLIDE IMAGING for the clinical evaluation of hepatobiliary disorders in humans.
Establishment of an opening into the gallbladder either for drainage or surgical communication with another part of the digestive tract, usually the duodenum or jejunum.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Infection with flukes of the genus Opisthorchis.
INFLAMMATION of the LIVER in non-human animals.
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)
Radiography of the gallbladder after ingestion of a contrast medium.
The part of the membranous labyrinth that traverses the bony vestibular aqueduct and emerges through the bone of posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) where it expands into a blind pouch called the endolymphatic sac.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A multisystem disorder that is characterized by aplasia of intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC), and malformations in the cardiovascular system, the eyes, the vertebral column, and the facies. Major clinical features include JAUNDICE, and congenital heart disease with peripheral PULMONARY STENOSIS. Alagille syndrome may result from heterogeneous gene mutations, including mutations in JAG1 on CHROMOSOME 20 (Type 1) and NOTCH2 on CHROMOSOME 1 (Type 2).
A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
Operation for biliary atresia by anastomosis of the bile ducts into the jejunum or duodenum.
Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
The return of a sign, symptom, or disease after a remission.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Hemorrhage in or through the BILIARY TRACT due to trauma, inflammation, CHOLELITHIASIS, vascular disease, or neoplasms.
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
A onecut transcription factor that regulates expression of GENES involved in EMBRYONIC DEVELOPMENT of the PANCREAS and LIVER.
A malignant epithelial tumor with a glandular organization.
Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.
Surgical portasystemic shunt between the portal vein and inferior vena cava.
Presence or formation of GALLSTONES in the GALLBLADDER.
Perisinusoidal cells of the liver, located in the space of Disse between HEPATOCYTES and sinusoidal endothelial cells.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
Repair or renewal of hepatic tissue.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A genus of trematode liver flukes of the family Opisthorchidae. It consists of the following species: O. felineus, O. noverca (Amphimerus noverca), and O. viverrini. The intermediate hosts are snails, fish, and AMPHIBIANS.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

Lobar decrease in 99mTc-GSA accumulation in hilar cholangiocarcinoma. (1/1066)

Hilar cholangiocarcinoma can obstruct hepatic ducts and involve the portal veins. Both biliary stasis and decrease in portal venous flow are known to reduce 99mTc-diethylenetriamine pentaacetic acid-galactosyl human serum albumin (GSA) accumulation. The specific relationship between these pathological conditions due to hilar cholangiocarcinomas and 99mTc-GSA accumulation has never been clarified. METHODS: Sixteen patients with hilar cholangiocarcinomas who underwent 99mTc-GSA liver scintigraphy were reviewed. The relationship between significant decrease in 99mTc-GSA accumulation and lobar biliary stasis, or decrease in the portal venous flow, was evaluated. Average counts of region of interest placed in both right and left lobes were compared in the same transaxial SPECT section. Count ratios of right and left lobes were calculated. RESULTS: Significant lobar decrease in 99mTc-GSA accumulation was observed in 6 of the 16 patients. Ipsilateral portal venous stenosis or obstruction was seen in all these 6 patients, whereas ipsilateral portal venous stenosis or obstruction was seen in only 1 of the other 10 patients. Symmetric bile duct dilatation was seen in 13 patients, and asymmetric bile duct dilatation was seen in 3. Lobar decrease in 99mTc-GSA accumulation correlated well with decrease in ipsilateral portal venous flow (P < 0.0005). The count ratio was significantly reduced when unilateral portal venous flow decreased (P < 0.05). CONCLUSION: Using 99mTc-GSA liver scintigraphy, we can predict lobar decrease in ipsilateral portal venous flow and monitor hepatic functional lateralities in patients with hilar cholangiocarcinomas.  (+info)

ANIT-induced disruption of biliary function in rat hepatocyte couplets. (2/1066)

alpha-Naphthylisothiocyanate (ANIT) induces intrahepatic cholestasis in rats, involving damage to biliary epithelial cells; our study aims to investigate whether disruption of biliary function in hepatocytes can contribute to early stages of ANIT-induced intrahepatic cholestasis. Isolated rat hepatocyte couplets were used to investigate biliary function in vitro by canalicular vacuolar accumulation (cVA) of a fluorescent bile acid analogue, cholyl-lysyl-fluorescein (CLF), within the canalicular vacuole between the two cells. After a 2-h exposure to ANIT, there was a concentration-dependent inhibition of cVA (cVA-IC50; 25 microM), but no cytotoxicity (LDH leakage or [ATP] decline) within this ANIT concentration range. There was no loss of cellular [GSH] at low ANIT concentrations, but, at 50 microM ANIT, a small but significant loss of [GSH] had occurred. Diethylmaleate (DEM) partially depleted cellular [GSH], but addition of 10 microM ANIT had no further effect on GSH depletion. Reduction in cVA was seen in DEM-treated cells; addition of ANIT to these cells reduced cVA further, but the magnitude of this further reduction was no greater than that caused by ANIT alone, indicating that glutathione depletion does not enhance the effect of ANIT. F-actin distribution (by phalloidin-FITC staining) showed an increased frequency of morphological change in the canalicular vacuoles but only a small, non-significant (0.05 < p < 0.1) increase in proportion of the F-actin in the region of the pericanalicular web. The results are in accord with a disruption of hepatocyte canalicular secretion within two h in vitro, at low, non-cytotoxic concentrations of ANIT, and the possible involvement of a thiocabamoyl-GSH conjugate of ANIT (GS-ANIT) in this effect.  (+info)

Lymph node metastasis in intrahepatic cholangiocarcinoma. (3/1066)

BACKGROUND: Lymph node metastasis is a significant prognostic factor in intrahepatic cholangiocarcinoma. This study was aimed at investigating lymph node metastasis in intrahepatic cholangiocarcinoma and to examine whether the extent of metastasis affects outcomes after surgery. METHODS: From 1980 through 1996, 70 patients with intrahepatic cholangiocarcinoma underwent hepatectomy, with a 50% curative resection rate. Lymph node dissection was performed in 51 patients, and the presence of lymph node metastasis was examined microscopically. The metastatic nodes were divided into groups N1, N2 or N3 using the classification proposed by the Liver Cancer Study Group of Japan. RESULTS: Twenty-three patients had lymph node metastasis. Metastasis was to N1 nodes in 10 patients, to N2 nodes in nine patients and to N3 nodes in four patients. Nineteen patients had metastatic nodes in the hepatoduodenal ligament, which was the most common metastatic site regardless of tumor location. The five-year survival rate in patients with lymph node metastasis (0%) was significantly lower (p < 0.0001) than that in patients without lymph node metastasis (51 %); however, five-year survival rates did not differ between patients with metastases to N1, N2 and N3 nodes. CONCLUSIONS: Lymph nodes in the hepatoduodenal ligament may be sentinel nodes for intrahepatic cholangiocarcinoma, and outcomes after surgery for patients with lymph node metastasis are poor regardless of the sites of nodal metastasis.  (+info)

Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. (4/1066)

The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats.  (+info)

Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. (5/1066)

Bile duct damage and/or loss is limited to a range of duct sizes in cholangiopathies. We tested the hypothesis that CCl4 damages only large ducts. CCl4 or mineral oil was given to bile duct-ligated (BDL) rats, and 1, 2, and 7 days later small and large cholangiocytes were purified and evaluated for apoptosis, proliferation, and secretion. In situ, we measured apoptosis by morphometric and TUNEL analysis and the number of small and large ducts by morphometry. Two days after CCl4 administration, we found an increased number of small ducts and reduced number of large ducts. In vitro apoptosis was observed only in large cholangiocytes, and this was accompanied by loss of proliferation and secretion in large cholangiocytes and loss of choleretic effect of secretin. Small cholangiocytes de novo express the secretin receptor gene and secretin-induced cAMP response. Consistent with damage of large ducts, we detected cytochrome P-4502E1 (which CCl4 converts to its radicals) only in large cholangiocytes. CCl4 induces selective apoptosis of large ducts associated with loss of large cholangiocyte proliferation and secretion.  (+info)

Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver. (6/1066)

p73, the first homologue of the tumour suppressor protein p53, was recently discovered on chromosome 1p36 and has been shown to induce apoptosis in a p53-like manner. The present study was performed with the aim of investigating the expression of p53, its new homologue p73 and the occurrence of apoptosis in cholangiocellular carcinoma. Protein levels of p73 were examined in 41 patients with curatively (R0-) resected cholangiocellular carcinomas with an antiserum, raised against a peptide in the N-terminal domain of p73. The incidence of mutations in the p53 gene was analysed by direct sequencing and also immunohistochemically. Apoptotic cell death was assessed using in-situ end-labelling (ISEL) technique in combination with morphological criteria. The results obtained were correlated with patient survival. Immunostaining of p73 protein was detected in 17/41 carcinomas examined (41%). The immunoreactivity was confined to the cell nucleus. In 15/41 patients (37%), mutations of the p53 gene were observed. Eleven out of these 15 patients stained also positive for p73. In contrast, out of 26 patients without any detectable p53 mutation, only six exhibited p73 immunostaining. We failed to observe a correlation between p73 expression or p53 and apoptosis within a given tumour. Survival analysis including the parameters stage and grade of disease, p73 and p53, and also apoptosis, showed that tumour stage and grade as well as p53 and p73 were significantly related to prognosis. In Cox regression survival analysis, however, only extent of primary tumour and lymph node status had an independent prognostic impact. Our results with a high prevalence of p73 within tumours harbouring mutated p53 gene suggest that p73 could compensate for p53 function. We failed to establish p73 or p53 as independent prognostic factors in cholangiocellular carcinoma of the liver.  (+info)

Intrahepatic peripheral cholangiocarcinoma: CT features in 18 pathologically proven cases. (7/1066)

OBJECTIVE: To determine the morphological features of 18 pathologically proven intrahepatic peripheral cholangiocarcinoma (IHPCC) cases in computerized tomography (CT) image. METHODS: All 18 patients had CT, using Picker I.Q.T/C and taking pre-contrast continuous 10-mm sections throughout the liver and post-contrast continuous 10-mm sections throughout the focuses. RESULTS: The disease was characterized in CT image by the following: all focuses were found in the periphery of the liver and shown as a lobulated or fused hypodense space-occupying mass; there were one or more divergent or confluent, circular or irregular cystic areas with much lower density, in the majority. All focuses could be enhanced slightly and most revealed a dim edge. Dilated bile ducts around the focus were found frequently; the dilated bile ducts especially seemed to encircle the focus (33.3%, 6/18). This phenomenon were referred to as "encysted sign of dilated bile ducts". CONCLUSIONS: CT scanning should be one of the most important investigative methods for IHPCC due to the disease characteristics identified in CT image, especially "encysted sign of dilated bile ducts" which possesses specificity in diagnosing the disease.  (+info)

Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits. (8/1066)

To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.  (+info)

TY - JOUR. T1 - Expression of matrix proteinases during human intrahepatic bile duct development. T2 - A possible role in biliary cell migration. AU - Terada, T.. AU - Okada, Y.. AU - Nakanuma, Y.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - Primitive biliary cells are known to migrate from the ductal plate into the mesenchyme during human intrahepatic bile duct development, and this migration process is essential for normal development of intrahepatic bile ducts. However, its molecular mechanism is unknown. Matrix proteinases play an important role in cell migration during cancer invasion and organ development. In this study, we therefore investigated in situ expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) during human intrahepatic bile duct development, using 32 human fetal livers. We also examined in situ expression of trypsinogen/trypsin, chymotrypsinogen/chymotrypsin, and cathepsin B, which are matrix proteinases and activators of MMP. MMP-1 expression was noted in ...
Libbrecht, Louis ; Desmet, Valeer ; Roskams, Tania. Stages of normal and aberrant intrahepatic bile duct development in a mixed hepatoblastoma.. In: Histopathology, Vol. 42, no.6, p. 618-20 (2003 ...
Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from normal livers and established in primary culture. The in vitro expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on biliary epithelial cells was studied in response to tumour necrosis factor-alpha (0-500 U/ml), interferon-gamma (0-500 U/ml), and interleukin-1 (0-5 U/ml) by immunohistochemical staining and a semiquantitative scoring system validated by spectrophotometry and previously validated by laser confocal microscopy. The non-stimulated expression of intercellular adhesion molecule-1 and HLA class II was higher on cells derived from the primary biliary cirrhosis liver than on cells from normal liver, a difference not seen with HLA class I expression. A statistically significant increase in intercellular adhesion molecule-1 expression was seen with all three cytokines in cells derived from both primary biliary cirrhosis and normal liver. ...
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Cholangiocyte cytokines stimulate inducible nitric oxide synthase (NOS2) to produce nitric oxide (NO), a known DNA mutagen linked to malignant transformation (5, 13). The generation of NO is also important for bile duct development because it induces Notch1 expression (14, 15). The four Notch genes identified in mammals (Notch 1-4) are expressed in a wide variety of cells and play a significant role in cellular differentiation. The activation of Notch by cell-to-cell interaction causes a transcriptional silencing effect that inhibits differentiation in some cells but not in others (16-18). While the Notch pathway is known to be associated with pancreatic carcinogenesis in rats and humans (19), this same pathway may also have a role in cholangiocarcinogenesis via NOS2.. Cyclooxygenase-2 (prostaglandin-endoperoxide synthase 2, PTGS2) is also implicated in the initiation of malignant cholangiocytes (20). PTGS2 is up-regulated in murine and rat models of biliary adenocarcinoma, while the antisense ...
Hepatitis C virus (HCV) is a variable RNA virus that can readily establish persistent infection. Cellular immune responses are important in the early control of the virus. Evidence from animal models suggests that mutation in epitopes recognized by CD8+ T lymphocytes may play an important role in the establishment of persistence but in human persistent infection, equivalent evidence is lacking. We investigated this by analysing a unique resource: viruses from a set of chronically HCV-infected individuals in whom the CD8+ T-cell responses in liver had previously been accurately mapped. Virus was sequenced in seven individuals at 10 epitopes restricted by 10 human leucocyte antigen (HLA) molecules. Two main patterns emerged: in the majority of epitopes sequenced, no variation was seen. In three epitopes, mutations were identified which were compatible with immune escape as assessed using phylogenetic and/or functional studies. These data suggest that - even where specific intrahepatic T cells are
Hepatitis C virus (HCV) is a variable RNA virus that can readily establish persistent infection. Cellular immune responses are important in the early control of the virus. Evidence from animal models suggests that mutation in epitopes recognized by CD8+ T lymphocytes may play an important role in the establishment of persistence but in human persistent infection, equivalent evidence is lacking. We investigated this by analysing a unique resource: viruses from a set of chronically HCV-infected individuals in whom the CD8+ T-cell responses in liver had previously been accurately mapped. Virus was sequenced in seven individuals at 10 epitopes restricted by 10 human leucocyte antigen (HLA) molecules. Two main patterns emerged: in the majority of epitopes sequenced, no variation was seen. In three epitopes, mutations were identified which were compatible with immune escape as assessed using phylogenetic and/or functional studies. These data suggest that - even where specific intrahepatic T cells are
Hepatitis C virus (HCV) is a variable RNA virus that can readily establish persistent infection. Cellular immune responses are important in the early control of the virus. Evidence from animal models suggests that mutation in epitopes recognized by CD8+ T lymphocytes may play an important role in the establishment of persistence but in human persistent infection, equivalent evidence is lacking. We investigated this by analysing a unique resource: viruses from a set of chronically HCV-infected individuals in whom the CD8+ T-cell responses in liver had previously been accurately mapped. Virus was sequenced in seven individuals at 10 epitopes restricted by 10 human leucocyte antigen (HLA) molecules. Two main patterns emerged: in the majority of epitopes sequenced, no variation was seen. In three epitopes, mutations were identified which were compatible with immune escape as assessed using phylogenetic and/or functional studies. These data suggest that - even where specific intrahepatic T cells are
INTRODUCTION: The liver is a multi-purposeful organ, susceptible to injury. Following acute injury, cells such as hepatocytes, regenerate, while latent hepatic progenitor cell (HPC) become active after chronic liver injury. Some studies suggest Fibroblast growth factors (FGF) may activate HPCs similarly to embryonic liver stem cells. In addition, Notch signaling is critical in bile duct development and injury. With progenitor cell transplantation as an alternative to tissue transplantation, we hypothesize that FGF and Notch signaling pathways induce proliferation of HPC after chronic liver injury.; MATERIALS AND METHODS: Wild-type mice were fed either regular or 0.1% 3,5-diethoxycarbonyl dihydrocollidine (DDC) chow to induce injury. Transgenic, dominant-negative RosartTA;tet(o)sFGFR2b+/- mice were given doxycycline 2 days prior and throughout DDC injury. mRNA and immunostaining of FGF and Notch receptors and ligands were performed. Cells isolated from transgenic mice were fluoresecently sorted ...
in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 16. Aim: Results of donation after circulatory death (DCD) liver transplantation (LT) are impaired by ischemic bile duct lesions caused by procurement warm ischemia. Donor age is a risk factor in deceased ... [more ▼]. Aim: Results of donation after circulatory death (DCD) liver transplantation (LT) are impaired by ischemic bile duct lesions caused by procurement warm ischemia. Donor age is a risk factor in deceased donor LT, and particularly in DCD-LT. At the authors institute, age is not an absolute exclusion criterion to discard DCD liver grafts, controlled DCD donors receive comfort therapy before withdrawal, and cold ischemia is minimized. The aim of the present study was to report on the results of the first 10 years of this experience, and particularly on graft survival and the rate of post-transplant biliary complications, according to DCD donor age. Methods: The authors retrospectively studied a consecutive series of 70 DCD-LT ...
Background:. Alcohol consumption is one of the most important known causes of human cancer after tobacco smoking.. Aim:. This study aims to estimate cancer incidence attributable to alcohol use in Brazil. The proportion of cancer cases that could be attributable to alcohol exposure was estimated for lip; oral cavity; nasopharynx and other pharynx; larynx; esophagus; colorectum; female breast; and liver and intrahepatic bile ducts. Methods:. The proportion of exposed cases and the association between alcohol and cancer was based on data made available by the Cancer Hospital Registries. The cancer incidence was obtained from the estimates produced by GLOBOCAN. We multiplied population aetiologic fraction (PAF) by the number of cases for each type of cancer by sex group and summed them. This study was approved by the Brazilian National Cancer Institute Ethics Committee.. Results:. In 2012 there were 437,592 new cancer cases in Brazil. Of these, alcohol drinking was responsible for 5.2% of all new ...
Lung scarring can be a highly dangerous condition and is usually caused by inhaling dangerous chemicals or by infections. Lung scarring is generally defined by which area of the lung is injured, with the perihilar area, which is the major entrance for the major veins and arteries of the lungs, being the most common.
CoCC shows a variable histological morphology depending on the extent of the associated ICC/HCC components. Such an inherent histological heterogeneity potentially complicates the pathologic diagnosis of CoCC. Komuta et al. proposed that CoCC is defined as when the proportion of CoCC accounts for more than 90% of the entire tumor [8]. According to this strict definition, CoCC with a significant proportion of ICC or HCC components may be considered to be an ordinary ICC or HCC, respectively [4]. The authors also reported immunohistochemical findings of a positive EMA at the apical membrane [6, 8, 9], positive NCAM (a marker of hepatic progenitor cells), and negative S100P (a marker of intrahepatic large bile ducts) [8]. As described, we made an incorrect initial diagnosis of ordinary ICC in the present patient, primarily because a lack of knowledge of CoCC led us not to consider the possibility of CoCC. There may be a concern that pathological diagnosis of the recurrent lesions treated with RFA ...
Congenital cystic dilatation of the intrahepatic biliary ducts, until recently, has been infrequently recognized. Three patients with this anomaly have been tre
Request for sample pages of the report: https://www.delveinsight.com/sample-request/intrahepatic-cholangiocarcinoma-market. Intrahepatic Cholangiocarcinoma (ICCA) Emerging Therapies:. 1. Pemazyre (Pemigatinib): Incyte Corporation. 2. Rozlytrek (Entrectinib): Roche. 3. Melphalan/HDS: Delcath Systems. 4. Derazantinib: Basilea Pharmaceutica. Intrahepatic Cholangiocarcinoma (ICCA) Market Outlook. Intrahepatic cholangiocarcinoma (ICCA) is the type of CCA that forms in the bile ducts inside the liver. The commonly available modalities for the treatment of ICCA include surgery and radiation therapies for curative intent and systemic therapies, including chemotherapy and chemoradiotherapy, for the surgery of ineligible patients.. Surgical resection is the mainstay for the treatment of ICCA. The main goal of the surgery is the hepatic resection with negative margins. Since this type of cancer occurs in the bile ducts inside the liver, surgery may include removing the section or wedge of the liver, and ...
TY - JOUR. T1 - Combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma. T2 - Outcome after liver transplantation. AU - Maganty, Kishore. AU - Levi, David. AU - Moon, Jang. AU - Bejarano, Pablo A.. AU - Arosemena, Leopoldo. AU - Tzakis, Andreas. AU - Martin, Paul. PY - 2010/12/1. Y1 - 2010/12/1. N2 - Background: Combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma is a rare hepatobiliary malignancy incorporating components derived from both hepatocyte and intrahepatic bile duct epithelium. The natural history, treatment, and prognosis of this distinct cancer differ from hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC) and are not completely understood. There is considerable controversy about the classification, treatment, and survival, which in turn is related to the rarity of the condition. Treatment options include surgical resection and the prognosis is believed to be better than CC but worse than HCC alone. Methods: We report a single-center liver ...
TY - JOUR. T1 - Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. AU - DeMorrow, Sharon. AU - Onori, Paolo. AU - Venter, Julie. AU - Invernizzi, Pietro. AU - Frampton, Gabriel. AU - White, Mellanie. AU - Franchitto, Antonio. AU - Kopriva, Shelley. AU - Bernuzzi, Francesca. AU - Francis, Heather. AU - Coufal, Monique. AU - Glaser, Shannon. AU - Fava, Giammarco. AU - Meng, Fanyin. AU - Alvaro, Domenico. AU - Carpino, Guido. AU - Gaudio, Eugenio. AU - Alpini, Gianfranco. PY - 2011/5. Y1 - 2011/5. N2 - No information exists on the role of neuropeptide Y (NPY) in cholangiocarcinoma growth. Therefore, we evaluated the expression and secretion of NPY and its subsequent effects on cholangiocarcinoma growth and invasion. Cholangiocarcinoma cell lines and nonmalignant cholangiocytes were used to assess NPY mRNA expression and protein secretion. NPY expression was assessed by immunohistochemistry in human liver biopsies. Cell proliferation and migration were evaluated in vitro by MTS ...
TY - JOUR. T1 - Comparative effectiveness of hepatic artery based therapies for unresectable intrahepatic cholangiocarcinoma. AU - Boehm, Lucas M.. AU - Jayakrishnan, Thejus T.. AU - Miura, John T.. AU - Zacharias, Anthony J.. AU - Johnston, Fabian M.. AU - Turaga, Kiran K.. AU - Gamblin, T. Clark. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Background: Hepatic artery based therapies (HAT) are offered for patients with unresectable intrahepatic cholangiocarcinoma (ICC). We aimed to evaluate the comparative effectiveness of HAT-hepatic arterial infusion (HAI), transcatheter arterial chemoembolization (TACE), drug-eluting bead TACE (DEB-TACE), and Yttrium90 radioembolization (Y-90) for unresectable ICC. Methods: A meta-analysis was performed using a prospectively registered search strategy at PROSPERO (CRD42013004830) that utilized PubMed (2003-2013). Primary outcome was median overall survival (OS), and secondary outcomes were tumor response to therapy and toxicity. Results: A total of 20 articles (of ...
Lymphoepithelioma-like carcinoma (LELC) of the liver is extremely rare. To our knowledge, only 16 cases of pure LELC or LELC with ordinary adenocarcinoma arising in the hepatobiliary tract have been reported in the English literature.1-7 Most of these tumours (68%, 11/16) were positive for Epstein-Barr virus (EBV) by EBV-encoded small non-polyadenylated RNA (EBER-1) in situ hybridisation.1-6 However, association of intrahepatic cholangiocarcinoma bearing an intense lymphoplasmacytic infiltration with EBV infection has not been reported. We were the first to present two cases of intrahepatic cholangiocarcinoma with dense lymphoplasmacytic infiltration from Southern China, an area that is well known for and has a high-incidence of nasopharyngeal carcinoma, showing EBV infection, but one case of LELC was associated with EBV infection as well. ...
The original observations of this study relate to inflammation, NO production, DNA damage, and inhibition of DNA repair as related mechanisms for the development and/or progression of cholangiocarcinoma. Our results directly demonstrate the following: (a) human cholangiocarcinomas express the iNOS protein; (b) proinflammatory cytokines stimulate iNOS message and protein expression and the production of NO in cholangiocarcinoma cell lines; (c) the magnitude of NO produced is sufficient to cause single-stranded, double-stranded, and oxidative DNA lesions in the malignant cell lines; and (d) stimulated NO generation is associated with impaired global DNA repair activity in the cholangiocarcinoma cell lines. These data suggest that NO generated in response to inflammation may initiate malignant transformation of biliary epithelia and/or promote progression of established cholangiocarcinoma. Each of these observations is discussed in greater detail below.. iNOS expression with NO generation has been ...
TY - JOUR. T1 - Characterization and growth regulation of a rat intrahepatic bile duct epithelial cell line under hormonally defined, serum-free conditions. AU - De Groen, Piet C.. AU - Vroman, Ben. AU - Laakso, Karen. AU - Larusso, Nicholas F.. N1 - Funding Information: We are indebted to Ms. Sue Kuntz for valuable help in electron microscopy, Ms. Pare Tietz for animal surgeries, and Dr. Vanda Lennon and Mn James Thorenson for performing the nude mouse experiments. This research was supported by grants from the NIH (DK24031) and Mayo Foundation.. PY - 1998. Y1 - 1998. N2 - Bile duct epithelial cells, or cholangiocytes, proliferate in vivo under a number of pathologic (i.e., partial hepatectomy) and pathophysiologic (i.e., bile duct ligation, malignant transformation) conditions. However, little is known about the possible growth factors that modulate these proliferative responses, in part because an in vitro model to study proliferation of nontransformed, normal cholangiocytes is not available. ...
TY - JOUR. T1 - The impact of portal vein resection on outcomes for hilar cholangiocarcinoma. T2 - A multi-institutional analysis of 305 cases. AU - De Jong, Mechteld C.. AU - Marques, Hugo. AU - Clary, Bryan M.. AU - Bauer, Todd W.. AU - Marsh, J. Wallis. AU - Ribero, Dario. AU - Majno, Pietro. AU - Hatzaras, Ioannis. AU - Walters, Dustin M.. AU - Barbas, Andrew S.. AU - Mega, Raquel. AU - Schulick, Richard D.. AU - Choti, Michael A.. AU - Geller, David A.. AU - Barroso, Eduardo. AU - Mentha, Gilles. AU - Capussotti, Lorenzo. AU - Pawlik, Timothy M.. PY - 2012/10/1. Y1 - 2012/10/1. N2 - BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar ...
Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical management. Despite developments in the molecular profiling of ICC, the preoperative prediction of prognosis remains a challenge. This study aimed to identify clinical prognostic indicators by investigating the molecular profiles of ICC and evaluating the preoperative imaging data of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET). A retrospective analysis was performed on 50 consecutive patients with ICC who underwent curative hepatectomy after 18F-FDG-PET examination. To evaluate the molecular profiles of ICC, KRAS mutation status was assessed in resected specimens. For the assessment of glucose uptake, we observed the expression of glucose transporter-1 (GLUT-1) by immunohistochemistry. The data of 18F-FDG-PET were re-evaluated as follows: maximum standardized uptake value,
Background: The aim of the present study was to analyze whether Homer1 is a potential prognostic markerfor intrahepatic cholangiocarcinoma (ICC). Materials and Methods: The expression of Homer1 in ICC tissuewas detected with immunohistochemistry and levels of protein in ICC and paratumor tissues were evaluated byWestern blotting. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance.Results: Homer1 expression was high in 67.4% (58/86) of ICC samples, and there was significant differencebetween ICC and adjacent noncancerous tissues (p|0.001); high expression was associated with poor histologicdifferentiation (p=0.019), TNM stage (p=0.014), lymph node metastasis (p=0.040), and lymphatic invasion(p=0.025). On Kaplan-Meier analysis, a comparison of survival curves of low versus high expressors of Homer1revealed a highly significant difference in OS (p=0.001) and DFS (p=0.006), indicating that high expressionof Homer1 was linked with a worse prognosis. Multivariate
Overview: In view of the increasing morbidity and mortality rates of Intrahepatic Cholangiocarcinoma (ICC) and the high risk of lymph node metastasis,..
Few studies have evaluated the risk of cancers other than hepatocellular carcinoma associated with hepatitis B virus (HBV) infection. This study aimed to estimate incidence rates of intrahepatic cholangiocarcinoma (ICC) and non-Hodgkin lymphoma (NHL) and its major subtypes in a nationwide cohort of parous women and to assess their associations with chronic HBV infection. We conducted a cohort study including 1,782,401 pregnant Taiwanese women whose HBV serostatus was obtained from the National Hepatitis B Vaccination Registry. Newly diagnosed ICCs and NHLs were ascertained through data linkage with the National Cancer Registry. Risks of ICC and NHL were assessed using Cox proportional hazards regression models. After a mean of 6.91 years of follow-up, there were 18 cases of ICC and 192 cases of NHL, including 99 cases of diffuse large B-cell lymphoma (DLBCL). Incidence rates of ICC were 0.09 and 0.43 per 100,000 person-years, respectively, among women who were hepatitis B surface antigen ...
The aim of this study was to compare the enhancement pattern of intrahepatic cholangiocarcinoma (ICC) on contrast-enhanced ultrasound (CEUS) with that on contrast-enhanced computed tomography (CECT). 40 pathologically proven ICC lesions in 40 patients were evaluated retrospectively with both CEUS and CECT. The enhancement level and pattern in the dynamic phases on both CEUS and CECT were analysed. The diagnostic results of CEUS and CECT before pathological examination were also recorded. During arterial phases, the number of lesions that appeared as (i) peripheral irregular rim-like hyperenhancement, (ii) diffuse heterogeneous hyperenhancement, (iii) diffuse homogeneous hyperenhancement and (iv) diffuse heterogeneous hypoenhancement were 19 (47.5%), 9 (22.5%), 5 (12.5%) and 7 (17.5%), respectively, on CEUS, and 22 (55.0%), 3 (7.5%), 2 (5.0%) and 13 (32.5%), respectively, on CECT (p = 0.125). In the portal phase, the number of lesions showing hyperenhancement and hypoenhancement were 1 (2.5%) and ...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive, highly lethal tumors and lacks of effective chemo and targeted therapies. Cell lines and animal models, even partially reflecting tumor characteristics, have limits to study ICC biology and drug response. In this work, we created and characterized a novel ICC patient-derived xenograft (PDX) model of Italian origin. Seventeen primary ICC tumors derived from Italian patients were implanted into NOD (Non-Obese Diabetic)/Shi-SCID (severe combined immunodeficient) mice. To verify if the original tumor characteristics were maintained in PDX, immunohistochemical (cytokeratin 7, 17, 19, and epithelial membrane antigen) molecular (gene and microRNA expression profiling) and genetic analyses (comparative genomic hybridization array, and mutational analysis of the kinase domain of EGFR coding sequence, from exons 18 to 21, exons 2 to 4 of K-RAS, exons 2 to 4 of N-RAS, exons 9 and 20 of PI3KCA, and exon 15 of B-RAF) were performed after tumor stabilization.
TY - JOUR. T1 - The Impact of Intraoperative Re-Resection of a Positive Bile Duct Margin on Clinical Outcomes for Hilar Cholangiocarcinoma. AU - Zhang, Xu Feng. AU - Squires, Malcolm H.. AU - Bagante, Fabio. AU - Ethun, Cecilia G.. AU - Salem, Ahmed. AU - Weber, Sharon M.. AU - Tran, Thuy. AU - Poultsides, George. AU - Son, Andre Y.. AU - Hatzaras, Ioannis. AU - Jin, Linda. AU - Fields, Ryan C.. AU - Weiss, Matthew J. AU - Scoggins, Charles. AU - Martin, Robert C.G.. AU - Isom, Chelsea A.. AU - Idrees, Kamron. AU - Mogal, Harveshp D.. AU - Shen, Perry. AU - Maithel, Shishir K.. AU - Schmidt, Carl R.. AU - Pawlik, Timothy M.. PY - 2018/2/22. Y1 - 2018/2/22. N2 - Background: The impact of re-resection of a positive intraoperative bile duct margin on clinical outcomes for resectable hilar cholangiocarcinoma (HCCA) remains controversial. We sought to define the impact of re-resection of an initially positive frozen-section bile duct margin on outcomes of patients undergoing surgery for HCCA. ...
Postoperative Mortality after Liver Resection for Perihilar Cholangiocarcinoma: Development of a Risk Score and Importance of Biliary Drainage of the Future Liver Remnant.
Hepatitis C virus (HCV) infects the liver and hepatocytes are the major cell type supporting viral replication. Hepatocytes and cholangiocytes derive from a common hepatic progenitor cell that proliferates during inflammatory conditions, raising the possibility that cholangiocytes may support HCV replication and contribute to the hepatic reservoir. We screened cholangiocytes along with a panel of cholangiocarcinoma-derived cell lines for their ability to support HCV entry and replication. While primary cholangiocytes were refractory to infection and lacked expression of several entry factors, two cholangiocarcinoma lines, CC-LP-1 and Sk-ChA-1, supported efficient HCV entry; furthermore, Sk-ChA-1 cells supported full virus replication. In vivo cholangiocarcinomas expressed all of the essential HCV entry factors; however, cholangiocytes adjacent to the tumour and in normal tissue showed a similar pattern of receptor expression to ex vivo isolated cholangiocytes, lacking SR-BI expression, explaining their
The purpose of this project is to evaluate the role of gadoxetate (Eovist) enhanced dual-energy CT in better evaluating perihilar cholangiocarcinoma, by exploiting the combination of the physiologic behavior of gadoxetate in liver tissue combined with the advantageous mass attenuation coefficient of Gadolinium achievable through dual energy technique. This combination of unique CT imaging sensitivity, high resolution and differential enhancement potentially allows improved visualization and detection of tumor relative to enhancing surrounding hepatic parenchyma and ductal anatomy in the hepatobiliary phase, due to the biliary excretion of the agent.. Cholangiocarcinoma is a hepatic adenocarcinoma that arises from the bile duct epithelium and is the second most prevalent liver cancer after hepatocellular carcinoma. The hilar intrahepatic variety of cholangiocarcinoma can present as an infiltrative, exophytic, or polypoid lesion. Most extra-hepatic cholangiocarcinomas are infiltrative, causing a ...
Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of risk factors. This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarcinoma, with a focus on inflammation and cholestasis as the driving forces in cholangiocarcinoma development. Cholestatic liver diseases (e.g. primary sclerosing cholangitis and fibropolycystic liver diseases), liver cirrhosis, and biliary stone disease all increase the risk of cholangiocarcinoma. Certain bacterial, viral or parasitic infections such as hepatitis B and C and liver flukes also increase cholangiocarcinoma risk. Other risk factors include inflammatory disorders (such as inflammatory bowel disease and chronic pancreatitis), toxins (e.g. alcohol and tobacco), metabolic conditions (diabetes, obesity and non
MeSH-minor] Adenoma, Liver Cell / mortality. Adenoma, Liver Cell / pathology. Adenoma, Liver Cell / surgery. Adrenal Gland Neoplasms / mortality. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / surgery. Adult. Bile Duct Neoplasms / mortality. Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / surgery. Breast Neoplasms / mortality. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Carcinoma, Hepatocellular / mortality. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Cholangiocarcinoma / surgery. Colorectal Neoplasms / mortality. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Female. Focal Nodular Hyperplasia / mortality. Focal Nodular Hyperplasia / pathology. Focal Nodular Hyperplasia / surgery. Hemangioma / mortality. Hemangioma / pathology. Hemangioma / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / ...
Cholangiocarcinoma (CCA), cancer of the bile duct, is the first cause of cancer death of the people in the northeast of Thailand. The incidence of CCA in this region is highest not only in the country but in the world. CCA is a slow growing but highly metastatic tumor. At present, there is no standard chemotherapy or effective treatment for CCA. Most of the patients have short survival after diagnosis. Strong evidences from in vitro, animal and clinical studies indicate that vitamin D can prevent and control growth of cancer. Our preclinical studies in CCA cell lines, animal and patient tissue culture indicate that vitamin D effectively reduce growth of CCA. Supplementation of vitamin D to chemotherapeutic drugs enhance drug toxicity and better response. At present, there are several clinical trials in USA on supplementation of vitamin D or its analogs to cancer patients. The side effect or toxicity of using vitamin D supplementation is low, some patients had stable disease and some had good ...
Kinetics, histological and biochemical characteristics of transplantable cholangiocellular RS-1 carcinoma were studied after intrahepatic and subcutaneous
Cholangiocarcinoma (CCA) is the second most common liver cancer and it is associated with a poor prognosis. CCA can be divided into intrahepatic, hilar and distal. Despite the subtype, the median survival is 12-24 months without treatment. Liver transplantation (LT) is worldwide recognized as a curative option for hepatocellular carcinoma. On the other hand, the initial results for LT for CCA were very poor mainly due to a lack of adequate patient selection. In the last two decades, improvement has been made in the management of unresectable hilar CCA, and the results of LT after neoadjuvant chemoradiation have been shown to be promising ...
Hilar cholangiocarcinoma (HCC) remains one of the most difficult tumors to stage and treat. The aim of the study was to assess the diagnostic efficiency of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computer tomography (PET/CT) in evaluating the resectability of HCC. A systematic search was performed of the PubMed, EMBASE, and Cochrane databases. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated for individual studies and pooled data as well as test for heterogeneity and public bias. Our data showed that CT had the highest pooled sensitivity at 95% (95% CI: 91–97), whereas PET/CT had the highest pooled specificity at 81% (95% CI: 69–90). The area under the curve (AUC) of CT, MRI, and PET/CT was 0.9269, 0.9194, and 0.9218, respectively. In conclusion, CT is the most frequently used imaging modality to assess HCC resectability with a good
Hepatocellular carcinoma (liver cell cancer) is the most common type of primary liver cancer. It is relatively rare in the United States but very common in Southeast Asia, especially China. The tumor predominantly affects males who are over 50 years of age, although it may arise in younger individuals or even children. The liver is also the primary site for cholangiocarcinomas (intrahepatic bile duct cancers) that are relatively rare and account for 10-20% of all primary liver cancers. These tumors occur in older individuals, usually after the age of 60. The overall median survival for hepatocellular carcinoma is 4 months and the overall 5-year survival rate is 3%. Cholangiocarcinomas have an overall mean survival time of less than 2 years. Several predisposing factors are thought to play a role in hepatocellular carcinoma. These include infection with hepatotropic viruses such as hepatitis B and C viruses, liver cirrhosis, liver cell dysplasia, exposure to aflatoxins and inborn errors of ...
시각화 및 마우스 간문맥 정맥 또는 intrahepatic의 담즙 덕트의 3 차원 구조를 정량화하는 방법이 설명되어 있습니다. 이 수지 주조 기술은 다른 ductal이나 혈관 시스템에 적용이 가능 할 수 있습니다...
Cholangiocarcinoma: A malignant tumor arising from the intrahepatic bile duct epithelium. It is composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant stroma. (From Holland et al., Cancer Medicine, 3d ed, p1455; Stedman, 25th ed)
Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The d-myo-inositol 1,4,5-trisphosphate (IP3)/Ca2+/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth. We evaluated the role of HRH3 in the regulation of cholangiocarcinoma growth. Expression of HRH3 in intrahepatic and extrahepatic cell lines, normal cholangiocytes, and human tissue arrays was measured. In Mz-ChA-1 cells stimulated with (R)-(α)-(−)-methylhistamine dihydrobromide (RAMH), we measured (a) cell growth, (b) IP3 and cyclic AMP levels, and (c) phosphorylation of PKC and mitogen-activated protein kinase isoforms. Localization of PKCα was visualized by immunofluorescence in cell smears and immunoblotting for PKCα in cytosol and membrane fractions. Following knockdown of PKCα, Mz-ChA-1 cells were stimulated with RAMH before evaluating cell growth and extracellular signal-regulated kinase (ERK)-1/2 phosphorylation. In vivo experiments were done in BALB/c ...
Background: iCCA is the 2nd most common liver malignancy and with a poor patient prognosis. The ABC-02 study established gemcitabine+cisplatin (gem-cis) as the standard of care (SOC) in 1st line (1L) systemic chemotherapy (CT). The objective was to examine the treatment (tx) patterns and time trends in the tx received by patients (pts) with iCCA in the United States before and after ABC-02 study was published. Methods: Retrospective data from the Optum Research Database, which included commercial and Medicare Advantage health plan members between January 1, 2006 and June 30, 2018, were used. Eligible pts were aged ≥ 18 years; had ≥ 2 nondiagnostic claims of primary iCCA diagnosis (International Classification of Disease [ICD]-9: 155.1 or ICD-10: C22.1) in the identification period (July 01, 2006-March 31, 2018); and had 6 months continuous enrollment prior to and ≥ 3 months follow-up (or less due to death) from the date of first diagnosis. Tx patterns in the periods before and after ABC-02 ...
In the west, the exact cause of cholangiocarcinoma is unclear. It is likely that this cancer arises due to a combination of factors, including other illnesses that cause chronic damage to the liver and/or bile ducts, certain toxins and possibly a small genetic predisposition, although it is not believed to be a directly inherited disease. Although most cases of cholangiocarcinoma are in people over 60 years of age, it appears to be increasing across all age groups including younger people. The cause of this ongoing rise is currently unknown.. In Southeast Asia, especially Thailand, which has the worlds highest incidence of cholangiocarcinoma, associated risk factors include eating raw fish infected with liver fluke and chronic typhoid, neither of which occurs in the western world.. ...
Sigma-Aldrich offers abstracts and full-text articles by [Maiko Terada, Kenichi Horisawa, Shizuka Miura, Yasuo Takashima, Yasuyuki Ohkawa, Sayaka Sekiya, Kanae Matsuda-Ito, Atsushi Suzuki].
A110 Cholangiocarcinoma (CCA), a malignant tumor of the bile duct epithelium, is one of the major of cancers in Northeast Thailand. This disease is difficult to diagnose and has a high mortality rate, thus posing an important public health problem in this region. Generally, cancer arises from dysregulation of tumor suppressor genes and oncogenes. c-Met, hepatocyte growth factor (HGF) receptor, and its ligand, HGF, regulate diverse biological responses including proliferation, migration and invasion, key features of metastatic cancer. Overexpression of c-Met has frequently been found in cholangiocarcinoma especially of well-differentiated type suggesting the role of c-Met in cholangiocarcinogenesis. In this study the role of HGF in invasiveness of cholangiocarcinoma was investigated using the human CCA cell line, KKU-213, in which c- Met expression is high when compare to immortalized cholangiocyte, H-69. Activation of c-Met by HGF induced KKU-213 cell proliferation, invasion and motility. ...
The Hippo pathway effector Yes-associated protein (YAP) is localized to the nucleus and transcriptionally active in a number of tumor types, including a majority of human cholangiocarcinomas. YAP activity has been linked to chemotherapy resistance and has been shown to rescue KRAS and BRAF inhibition in RAS/RAF-driven cancers; however, the underlying mechanisms of YAP-mediated chemoresistance have yet to be elucidated. Herein, we report that the tyrosine phosphatase SHP2 directly regulates the activity of YAP by dephosphorylating pYAPY357 even in the setting of RAS/RAF mutations, and that diminished SHP2 phosphatase activity is associated with chemoresistance in cholangiocarcinomas. A screen for YAP-interacting tyrosine phosphatases identified SHP2, and characterization of cholangiocarcinomas cell lines demonstrated an inverse relationship between SHP2 levels and pYAPY357. Human sequencing data demonstrated lower SHP2 levels in cholangiocarcinomas tumors as compared with normal liver. Cell lines ...
TT-00420, a multi-target novel kinase inhibitor that can conveniently taken via once daily oral administration, has proven to be safe and well tolerated in the Phase I clinical study. In addition, TT-00420 has shown promising clinical benefit potential in adult patients with advanced cholangiocarcinoma who received TT-00420 at different dose levels ranged from 8 mg to 12 mg. In this webinar, Dr. Javle, a leading key opinion leader in cholangiocarcinoma innovative drug development, will review the two cases of advanced CCA patients who achieved partial responses in TT-00420 Phase I study. Dr. Javle will further share more scientific background about TT-00420, especially the tumor grown inhibition shown in nonclinical PDX study for CCA without FGFR alternations. TT-00420 is developed by TransThera Biosciences, who is dedicatedly working on the late phase development of TT-00420 in CCA in the U.S., so to offer more effective treatment options to CCA patients.. ...
The biliary tree consists of intrahepatic and extrahepatic bile ducts and is lined by biliary epithelial cells (or cholangiocytes). There are also peribiliary glands around the intrahepatic large bile ducts and extrahepatic bile ducts. The biliary tr
BACKGROUND Intrahepatic cholangiocarcinoma is a rare condition which typically occurs in males between 50 and 70 years of age, and presents with symptoms related to biliary obstruction including jaundice, pruritus, and dark urine. Other common symptoms at presentation include abdominal pain, weight loss, and fever. CASE REPORT We present a case of a 67-year-old female initially presenting with chest pain at rest, found to have a lung nodule on diagnostic imaging at the time of admission. On further imaging, a 9 cm liver lesion was incidentally discovered, initially suspicious for hepatocellular carcinoma on imaging, with initial biopsy staining CK7 positive, and CK20 negative ...
TY - JOUR. T1 - SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma. AU - Merino-Azpitarte, Maite. AU - Lozano, Elisa. AU - Perugorria, María J.. AU - Esparza-Baquer, Aitor. AU - Erice, Oihane. AU - Santos-Laso, Álvaro. AU - ORourke, Colm J.. AU - Andersen, Jesper B.. AU - Jiménez-Agüero, Raúl. AU - Lacasta, Adelaida. AU - DAmato, Mauro. AU - Briz, Óscar. AU - Jalan-Sakrikar, Nidhi. AU - Huebert, Robert C.. AU - Thelen, Kristen M.. AU - Gradilone, Sergio A.. AU - Aransay, Ana M.. AU - Lavín, José L.. AU - Fernández-Barrena, Maite G.. AU - Matheu, Ander. AU - Marzioni, Marco. AU - Gores, Gregory J.. AU - Bujanda, Luis. AU - Marin, José J.G.. AU - Banales, Jesús M.. PY - 2017/7/1. Y1 - 2017/7/1. N2 - Background & Aims Cholangiocarcinoma (CCA) is a biliary malignancy linked to genetic and epigenetic abnormalities, such as hypermethylation of SOX17 promoter. Here, the role of SOX17 in cholangiocyte differentiation and ...
Sigma-Aldrich offers abstracts and full-text articles by [Papavee Samatiwat, Auemduan Prawan, Laddawan Senggunprai, Veerapol Kukongviriyapan].
In the transverse image, the common bile duct (red arrowheads) is anterior to the portal vein (PV) and the gallbladder (red arrow) is also visualized.. Exam Begin with the patient in the left posterior oblique position. Patient may also be placed in the supine position. Obtain longitudinal and transverse views of right and left lobe of liver and include longitudinal images of liver/diaphragm interface. Measure intrahepatic bile duct, common hepatic duct (CHD), and CBD as far distal as possible. Acquire longitudinal view of bile duct in pancreatic head and take measurement. Document patency in portal veins, hepatic veins, and hepatic artery. Sonographic Findings: 1) Shotgun sign intrahepatic biliary ducts (IHBD) become tortuous and their diameter exceeds 2 mm or exceeds 40% of the diameter of the adjacent PV. Color Doppler is used to confirm the absence of blood flow in the enlarged biliary tubes.. ...
Cholangiocellular Carcinoma in Dogs Bile duct carcinoma is a malignant cancer that typically arises from the the epithelia, the cellular lining of the hepatic (
Looking for biliary system? Find out information about biliary system. The complex of canaliculi, or microscopic bile ducts, that empty into the larger intrahepatic bile ducts Explanation of biliary system
Discussion This is the first study that demonstrates the effects of glyphosate on cholangiocarcinoma cells, and provides a better understanding of the possible mechanisms related to its effects. The low concentrations of glyphosate tested in this study are relevant to the range of levels that have been reported in the environment and detected in humans (Acquavella et al., 2004; Bai and Ogbourne, 2016; Kongtip et al., 2017). Previous studies have reported that E2 induces cell proliferation in an ERα expressing CCA, HuH28 cell line (Alvaro et al., 2006). It was reported that E2 also induced the expression levels of several proteins, including ERα, VEGF, VEGFR, IGF-1, and IGF-1R, as well as downstream signaling proteins associated to cell proliferation. In this study, we found that 10−11 to 10−5 M of glyphosate and E2 induced cell proliferation in HuCCA-1 cells under estrogen withdrawal conditions and the inductive effects were inhibited by ER antagonists. This study also demonstrated the ...
TY - JOUR. T1 - Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis. AU - Mao, Tin K.. AU - Kimura, Yasunori. AU - Kenny, Thomas P.. AU - Branch, Andrea. AU - Gish, Robert G.. AU - Van de Water, Judith A. AU - Kung, Hsing-Jien. AU - Friedman, Scott L.. AU - Gershwin, M. Eric. PY - 2002/12. Y1 - 2002/12. N2 - Background: Primary biliary cirrhosis (PBC) is characterized by chronic progressive destruction of small intrahepatic bile ducts with portal inflammation and cholestasis, leading to fibrosis. Methods: We utilized a novel restriction analysis system to profile the expression of tyrosine kinases (TKs). This methodology targets a conserved sequence present in the majority of human TKs, and exploits the known restriction map of the TK cDNA sequences. We isolated mRNA from biliary epithelial cell (BEC)-enriched cell fractions, amplified the TK transcripts using degenerative primers, and identified specific TKs by restriction enzyme digest analysis and then performed in situ ...
Case History-A 60 yr old woman presenting with abnormal liver blood tests.Primary biliary cirrhosis is a chronic, cholestatic liver disease in which the biliary epithelial cells lining the small intrahepatic bile ducts are the target for immune-mediated damage leading to progressive ductopenia. The cause is unknown, but presumed to be autoimmune....
de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., Oosterhuis, D., Iswandana, R., Suriguga, S., Overi, D., Lisman, T., Carpino, G., Gouw, A. S. H., Olinga, P., Gaudio, E. & Porte, R. J., Aug-2019, In : Transplantation. 103, 8, p. 3-3 1 p.. Research output: Contribution to journal › Meeting Abstract › Academic ...
ABSTRACT: Beaked whales are among the least known group of cetaceans, and information regarding their pathology and parasitology are especially scarce. We describe a case of significant parasitism by a trematode found in the liver of an adult male Hubbs beaked whale Mesoplodon carlhubbsi that stranded in Hokkaido, Japan. Post-mortem examinations revealed a localised area of discolouration restricted to the hilar region of the left hepatic lobe, where spindle-shaped trematodes occupied the dilated and hypertrophic bile ducts. Histologically, the intrahepatic bile ducts were characterised by adenomatous hyperplasia with goblet cell metaplasia of the biliary epithelium. Findings in the adjacent hepatic parenchyma included pseudocarcinomatous ductular reactions obliterating hepatocytes, a histomorphology not previously reported in marine mammals. Morphological identification of the trematode corresponded to Oschmarinella macrorchis, which has only been reported once in a Stejnegers beaked whale M. ...
BACKGROUND: Primary biliary cirrhosis is a chronic progressive cholestatic liver disease of presumed autoimmune etiology, characterised by the destruction of small intrahepatic bile ducts and the eventual development of cirrhosis and liver failure. Its progression may be influenced by immunosuppression. Glucocorticosteroids are potent immunosuppressive agents, but they are associated with significant adverse effects, including osteoporosis.. OBJECTIVES: To systematically evaluate the beneficial and harmful effects of glucocorticosteroids versus placebo or no intervention for patients with primary biliary cirrhosis.. SEARCH STRATEGY: The Cochrane Hepato-Biliary Controlled Trials Register,The Cochrane Library, MEDLINE, EMBASE, and the full text of the identified studies were searched until June 2004. The search strategy included terms for primary biliary cirrhosis and glucocorticosteroids (including the names of frequently used preparations). Previous research groups and manufacturers were ...
Malignant neoplasm of liver and intrahepatic bile ducts. The most frequent forms are metastatic malignant neoplasm of liver) ... bile duct) spasm of sphincter of Oddi biliary cyst biliary atresia ICD-10 codes K70-K77: Liver Diseases [1]. ... of liver malignant neoplasm of the gallbladder malignant neoplasm of other parts of biliary tract extrahepatic bile duct ...
In terms of mortality, the 5-year survival rate for liver and intrahepatic bile duct cancers in the United States is 19.6%. In ... In the United States there were 42,810 new cases of liver and intrahepatic bile duct cancer in 2020, which represents 2.4% of ... "SEER Stat Fact Sheets: Liver and Intrahepatic Bile Duct Cancer". NCI. Archived from the original on 2017-07-28. World Cancer ... "Cancer of the Liver and Intrahepatic Bile Duct - Cancer Stat Facts". SEER. Retrieved 2021-02-23. EASL Guideline Liver cancer ...
"Etiological Causes of Intrahepatic and Extrahepatic Bile Duct Dilatation" (PDF). International Journal of New Technology and ...
"The role of notch signaling in the development of intrahepatic bile ducts". Gastroenterology. 127 (6): 1775-1786. doi:10.1053/j ... When Hes1 expression is low, hepatocytes form normally, but bile ducts are completely absent. This phenotype resembles Alagille ...
Liver abscesses may be seen even without dilatation of intrahepatic bile ducts. While normally asymptomatic, most pathological ... The free metacercariae penetrate the intestinal mucosa and enter the bile ducts. Migration into the bile ducts takes 1-2 days. ... In humans, it infects the common bile duct and gall bladder, feeding on bile. It was discovered by British physician James ... bile duct obstruction, and even liver cirrhosis, cholangiocarcinoma, and hepatic carcinoma. As a major causative agent of bile ...
This species had produced megaloschizonts in the intrahepatic bile ducts and portal veins. The presence of these ...
Vital and scaffolding structures (like large blood vessels, urethra or intrahepatic bile ducts) are conserved. The electrically ... portal veins and intrahepatic bile ducts were all preserved. In IRE the cell death is mediated by apoptosis. Structures mainly ... June 2020). Hepatic IRE appears to be safe, even when performed near vessels and bile ducts with an overall complication rate ...
"Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome". ...
When the intrahepatic bile duct wall has protrusions, it is clearly seen as central dots or a linear streak. Caroli disease is ... bile ducts due to ectasia. Using an ultrasound, tubular dilation of the bile ducts can be seen. On a CT scan, Caroli disease ... He described it as "nonobstructive saccular or fusiform multifocal segmental dilatation of the intrahepatic bile ducts"; ... 2007). "Bile duct cyst type V (Caroli's disease): surgical strategy and results". HPB (Oxford). 9 (4): 281-4. doi:10.1080/ ...
Bile ducts: 2. Intrahepatic bile ducts, 3. Left and right hepatic ducts, 4. Common hepatic duct, 5. Cystic duct, 6. Common bile ... The intercalated ducts drain into larger ducts within the lobule, and finally interlobular ducts. The ducts are lined by a ... Two ducts, the main pancreatic duct and a smaller accessory pancreatic duct, run through the body of the pancreas, joining with ... forming the main pancreatic duct. The duct of the dorsal bud regresses, leaving the main pancreatic duct.[10] ...
Biliary cystadenoma and cystadenocarcinoma constitute less than 5% of intrahepatic cysts originating from the bile duct. ... Ahmad, Zubair; Uddin, Nasir; Memon, Wasim; Abdul-Ghafar, Jamshid; Ahmed, Arsalan (2017-11-10). "Intrahepatic biliary ...
Obstruction of the bile ducts by gallstones (choledocholithiasis), primary sclerosing cholangitis, liver damage (intrahepatic ... The absence of bile secretion can cause the feces to turn gray or pale. Other features of fat malabsorption may also occur such ... Possible causes include exocrine pancreatic insufficiency, with poor digestion from lack of lipases, loss of bile salts, which ...
Bile ducts: 2. Intrahepatic bile ducts, 3. Left and right hepatic ducts, 4. Common hepatic duct, 5. Cystic duct, 6. Common bile ... Bile canaliculi ,, Canals of Hering ,, intrahepatic bile ductule (in portal tracts / triads) ,, interlobular bile ducts ,, left ... Bile is secreted by the liver into small ducts that join to form the common hepatic duct. Between meals, secreted bile is ... Bile is secreted by the liver into small ducts that join to form the common hepatic duct. Between meals, secreted bile is ...
Tumors occurring in the bile ducts within the liver are referred to as intrahepatic, those occurring in the ducts outside the ... Cholangiocarcinoma, also known as bile duct cancer, is a type of cancer that forms in the bile ducts.[2] Symptoms of ... American Cancer Society Detailed Guide to Bile Duct Cancer.. *Patient information on extrahepatic bile duct tumors, from the ... ERCP image of cholangiocarcinoma, showing common bile duct stricture and dilation of the proximal common bile duct ...
Where formation of stones are not strictly in gallbladder, hence not fibrotic, but in the intrahepatic bile ducts). To ... Double gallstones with one falling and blocking the common bile duct (responsible for jaundice) and one at the cystic duct ( ... The exceptions to the law are stones that dislodge and acutely block the duct distally to the hepatic/cystic duct junction: ... in the case of recurrent pyogenic cholangitis complicated by calcium bilirubinate stone dislodging to the common bile duct ...
... involving saccular or fusiform dilatation of a portion or entire common bile duct (CBD) with normal intrahepatic duct. Type II ... Choledochal cysts (a.k.a. bile duct cyst) are congenital conditions involving cystic dilatation of bile ducts. They are ... inflammation within the bile ducts caused by the spread of bacteria from the intestine into the bile ducts). Inflammation of ... Multiple dilatations involving only the extrahepatic bile ducts. Type V: Cystic dilatation of intrahepatic biliary ducts ...
Tumors occurring in the bile ducts within the liver are referred to as intrahepatic, those occurring in the ducts outside the ... Cholangiocarcinoma, also known as bile duct cancer, is a type of cancer that forms in the bile ducts. Symptoms of ... American Cancer Society Detailed Guide to Bile Duct Cancer. Patient information on extrahepatic bile duct tumors, from the ... Intrahepatic cholangiocarcinomas (those arising from the bile ducts within the liver) are usually treated with partial ...
... cystic duct MeSH A03.159.183.079.600 - hepatic duct, common MeSH A03.159.183.158 - bile ducts, intrahepatic MeSH A03.159. ... MeSH A03.159.183.079 - bile ducts, extrahepatic MeSH A03.159.183.079.300 - common bile duct MeSH A03.159.183.079.300.950 - ... salivary ducts MeSH A03.556.500.760.650 - salivary glands, minor MeSH A03.556.500.760.687 - sublingual gland MeSH A03.556. ... bile canaliculi MeSH A03.734.414.065 - glucagon-secreting cells MeSH A03.734.414.131 - insulin-secreting cells MeSH A03.734. ...
... genetic defect resulting in hypoplastic intrahepatic bile ducts) Progressive familial intrahepatic cholestasis Pyknocytosis ( ... is caused by a blockage of bile ducts that transport bile containing conjugated bilirubin out of the liver for excretion. This ... increased conjugated bilirubin and bile salts. In complete obstruction of the bile duct, conjugated bilirubin cannot access the ... If a bile duct blockage is present, surgery is typically required; otherwise, management is medical. Surgery in patients with ...
... is seen due to portal hypertension caused by compression of portal veins by the proximate sclerosed intrahepatic bile ducts, ... The resulting scarring of the bile ducts obstructs the flow of bile, which further perpetuates bile duct and liver injury. ... The bile duct scarring which occurs in PSC narrows the ducts of the biliary tree and impedes the flow of bile to the intestines ... infection within the bile ducts) can be seen due to impaired drainage of the bile ducts, which increases the risk of infection ...
... common bile duct neoplasms MeSH C06.130.320.120 - bile duct neoplasms MeSH C06.130.320.120.280 - common bile duct neoplasms ... intrahepatic MeSH C06.130.120.135.250.125 - alagille syndrome MeSH C06.130.120.135.250.250 - liver cirrhosis, biliary MeSH ... MeSH C06.130.120.120 - bile duct neoplasms MeSH C06.130.120.120.280 - common bile duct neoplasms MeSH C06.130.120.123 - biliary ... bile duct neoplasms MeSH C06.301.120.250.250 - common bile duct neoplasms MeSH C06.301.120.401 - gallbladder neoplasms MeSH ...
... but also the so-called intra-hepatic stones from the bile ducts of the liver by this procedure. There are different sets of ...
Progressive familial intrahepatic cholestasis, bile duct paucity, Alagille syndrome, alpha 1-antitrypsin deficiency, and other ... Cystic fibrosis Dubin-Johnson syndrome Rotor syndrome Drugs Total parenteral nutrition Idiopathic Biliary atresia or bile duct ...
It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up ... with the intralobular ducts and the canals of Hering (intrahepatic ductules) being affected early in the disease. Most people ... small duct PSC, adult idiopathic ductopenia. Stage 1 - portal stage: Normal-sized triads, portal inflammation, subtle bile duct ... In the new system of Nakanuma, the stage of disease is based on fibrosis, bile duct loss, and features of cholestasis, i.e. ...
... intrahepatic - intrahepatic bile ducts - intrahepatic infusion - intralesional - intraluminal intubation and dilation - ... common bile duct - comorbidity - compassionate use trial - complementary and alternative medicine - complete blood count (CBC ... bile duct - biliary - bilirubin - binding agent - bioavailable - biochanin A - biochemical reactions - biological response ... pancreatic duct - pancreatic enzyme - pancreatic juice - pancreatitis - PAP, same as Pap smear - Pap smear - Pap test, same as ...
... a freshwater catfish Malignant neoplasms of liver and intrahepatic bile ducts ICD-10 code Centre Municipal Airport FAA LID This ...
155 Malignant neoplasm of liver and intrahepatic bile ducts 156 Malignant neoplasm of gallbladder and extrahepatic bile ducts ... 237 Neoplasm of uncertain behavior of endocrine glands and nervous system 237.0 Pituitary gland and craniopharyngeal duct ...
... where they merge to form bile ducts. Within the liver, these ducts are termed intrahepatic bile ducts, and once they exit the ... The cystic duct from the gallbladder joins with the common hepatic duct to form the common bile duct. The biliary system and ... They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts ... or is temporarily stored in the gallbladder via the cystic duct. The common bile duct and the pancreatic duct enter the second ...
In these infants, the bile is not able to drain normally from the small bile ducts within the liver into the larger bile ducts ... the fibrous tissue of the porta hepatis and thus provide direct connection with the intrahepatic ductule system to allow bile ... The rationale for this approach is that minute residual bile duct remnants may be present in ... by radical excision of all bile duct tissue up to the liver capsule and attaching a Roux-en-Y loop of jejunum to the exposed ...
Interlobular bile ducts (between the interlobar ducts and the lobules) - simple columnar epithelium. Intralobular bile ducts ( ... Intrahepatic bile ducts compose the outflow system of exocrine bile product from the liver. They can be divided into: Lobar ... Interlobar ducts (between the main hepatic ducts and the interlobular ducts) - pseudostratified columnar epithelium. ... ducts (right and left hepatic ducts) - stratified columnar epithelium. ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ...
Bile ducts. *Intrahepatic bile ducts *Bile canaliculus. *Canals of Hering. *Interlobular. *Left hepatic duct ... This duct joins with the cystic duct to connect in a common bile duct with the gallbladder. Bile is stored in the gallbladder ... Bile flows from the liver through the bile ducts and into the gall bladder for storage. The bile is released in response to ... It connects to the duodenum via the pancreatic duct which it joins near to the bile duct's connection where both the bile and ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ... including the gallbladder and bile ducts. The image produced by this type of medical imaging, called a cholescintigram, is also ... where it is excreted into the bile ducts and stored by the gallbladder[1] until released into the duodenum. ... If the gallbladder is not visualized within 4 hours after the injection, this indicates either cholecystitis or cystic duct ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ...
6,0 6,1 «SEER Stat Fact Sheets: Liver and Intrahepatic Bile Duct Cancer»։ NCI։ Արխիվացված օրիգինալից 2017-07-28-ին։ Վերցված է ... Davit-Spraul A, Gonzales, E, Baussan, C, Jacquemin, E (Jan 8, 2009)։ «Progressive familial intrahepatic cholestasis»։ Orphanet ... Malaguarnera G, Paladina, I, Giordano, M, Malaguarnera, M, Bertino, G, Berretta, M (2013)։ «Serum markers of intrahepatic ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ...
Bile ducts. *Intrahepatic bile ducts *Bile canaliculus. *Canals of Hering. *Interlobular. *Left hepatic duct ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ... loss after obesity surgery can contribute to the development of gallstones as well by increasing the lithogenicity of bile. ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ...
... progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a ... with the intralobular ducts and the Canals of Hering (intrahepatic ductules) being affected early in the disease.[13] This ... Abdominal ultrasound, MR scanning (MRCP) or a CT scan is usually performed to rule out blockage to the bile ducts. This may be ... Stage 1 - Portal Stage: Normal sized triads; portal inflammation, subtle bile duct damage. Granulomas are often detected in ...
Bile duct/ Other biliary tree. *Cholangitis *Primary sclerosing cholangitis. *Secondary sclerosing cholangitis ... Hepatic encephalopathy may also occur after the creation of a transjugular intrahepatic portosystemic shunt (TIPS). This is ...
UDCA has also been used in non-alcoholic fatty liver disease, in liver bile duct-paucity syndromes such as biliary atresia, ... Intrahepatic cholestasis of pregnancy[edit]. UDCA has been used for intrahepatic cholestasis of pregnancy. UDCA lessens itching ... primary bile acids can be metabolized into secondary bile acids by intestinal bacteria. Primary and secondary bile acids help ... In purified form, it has been used to treat or prevent several diseases of the liver or bile ducts. ...
Obstruction of the bile ducts by gallstones (choledocholithiasis), primary sclerosing cholangitis, liver damage (intrahepatic ... The absence of bile secretion can cause the feces to turn gray or pale. Other features of fat malabsorption may also occur such ... Possible causes include exocrine pancreatic insufficiency, with poor digestion from lack of lipases, loss of bile salts, which ...
Bile ducts: 2. Intrahepatic bile ducts, 3. Left and right hepatic ducts, 4. Common hepatic duct, 5. Cystic duct, 6. Common bile ... The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct. The duct is ... 8: Common bile duct. 9: Hepatic artery. 10: Portal vein. 11: Cystic duct. 12: Common hepatic duct. 13: Gallbladder ... The common hepatic duct is the part of the biliary tract formed by the convergence of the right hepatic duct (which drains bile ...
Biliary atresia, or inflammation and destruction of the bile ducts, may lead to jaundice. Vomiting and swelling of the ... Vascular abnormalities: Interrupted inferior vena cava, Bilateral superior or inferior venae cavae Intrahepatic interruption of ... In this surgery, a Y-shaped shunt is used to passage bile from the liver directly to the intestine. If this is unsuccessful, ... A majority of left atrial isomeric patients have defects throughout the biliary tree, which is responsible for bile production ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ... Excessive salivation and alkaline bile reflux into the stomach can shift the pH value of the biopsy of the stomach towards ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ... ligation - tying off blood vessels, ducts, or "tubes".. *grafts - may be severed pieces of tissue cut from the same (or ...
Bile duct cancer: cause and treatment *↑ Nakeeb A, Pitt HA, Sohn TA, Coleman J, Abrams RA, Piantadosi S, Hruban RH, Lillemoe KD ... A spectrum of intrahepatic, perihilar, and distal tumors". Annals of Surgery. 224 (4): 463-73, discussion 473-5. doi:10.1097/ ... "Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®)-Health Professional Version". National Cancer Institute. 14 March 2018. ... "Bile Duct Cancer (Cholangiocarcinoma) Symptoms, Tests, Prognosis, and Stages". National Cancer Institute. 5 July 2018. ...
"SEER Stat Fact Sheets: Liver and Intrahepatic Bile Duct Cancer"। NCI। সংগ্রহের তারিখ 2016।. এখানে তারিখের মান পরীক্ষা করুন: , ...
... or blockage of the bile duct.[3] In the developed world, the cause is more often blockage of the bile duct or medications while ... In addition, swelling of cells and oedema due to inflammation cause mechanical obstruction of intrahepatic biliary tree. Hence ... can live in the common bile duct, causing obstructive jaundice. Other causes include strictures of the common bile duct, ... The most common causes are gallstones in the common bile duct, and pancreatic cancer in the head of the pancreas. Also, a group ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ... The much longer pathway, the biliopancreatic loop, carries bile from the liver to the common channel. ... in which the contents of the digestive path mix with the bile from the biliopancreatic loop before emptying into the large ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ...
Discrete localized enlargements of normal structures (ureters, blood vessels, intrahepatic or extrahepatic biliary ducts, ... Bile acids, at high levels in the colons of humans eating a high fat diet, also cause DNA damage and contribute to colon cancer ... "Carcinogenicity of deoxycholate, a secondary bile acid". Arch. Toxicol. 85 (8): 863-71. doi:10.1007/s00204-011-0648-7. PMC ...
Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt procedure. Gallbladder, bile duct. * ...
對能進行手術的病例而言,手術成功的機率取決於腫瘤的位置,以及腫瘤是否能加以根除。遠端型膽管癌(腫瘤發生於總膽管(英语:Common bile duct))患者通常會進行胰十二指腸切除術(英语:Whipple procedure),長期存活率為15%-25 ... A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg. 1996, 224 (4): 463-73; discussion 473-5. PMC 1235406. PMID ... common bile duct),而此類腫瘤無法手術切除,因此僅
Interlobular bile ducts (between the interlobar ducts and the lobules) - simple columnar epithelium. Intralobular bile ducts ( ... Intrahepatic bile ducts compose the outflow system of exocrine bile product from the liver. They can be divided into: Lobar ... Interlobar ducts (between the main hepatic ducts and the interlobular ducts) - pseudostratified columnar epithelium. ... ducts (right and left hepatic ducts) - stratified columnar epithelium. ...
Learn how intrahepatic bile duct cancer is staged. ... Determining the stage of bile duct cancer helps doctors decide ... Staging of Intrahepatic Bile Duct Cancers. After a person is diagnosed with intrahepatic bile duct cancer, doctors will try to ... Distal Bile Duct Cancer Stages (for cancers starting farther down the bile duct) ... Staging systems for cancers starting in other parts of the bile ducts are described in:. *Perihilar Bile Duct Cancer Stages ( ...
Sherlock S (1987) The syndrome of disappearing intrahepatic bile ducts. Lancet 29: 493-496Google Scholar ... Bile Duct Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Hepatic Duct Sclerosing Cholangitis These keywords were ... 2006) Intrahepatic Bile Ducts. In: MR Cholangiopancreatography. Springer, Berlin, Heidelberg. * DOI https://doi.org/10.1007/3- ... 1992) Mechnisms of major bile duct injury during laparoscopic cholecystectomy. Ann Surg 215: 196-202PubMedGoogle Scholar ...
Liver and Intrahepatic Bile Duct Cancer, United States-2006-2015. USCS data brief, no 5. Atlanta, GA: Centers for Disease ... Liver and Intrahepatic Bile Duct Cancer, United States-2006-2015. *Cancers Associated with Human Papillomavirus, United States- ... From 2006 to 2015, the incidence rate for liver and intrahepatic bile duct cancer increased by 32%, and the mortality rate ... In 2015, 32,908 new liver and intrahepatic bile duct cancer cases and 25,760 deaths were reported in the United States. ...
Liver and intrahepatic bile ducts - tumor. Miscellaneous. Grossing. Reviewers: Deepali Jain, M.D. (see Reviewers page) Revised: ... End of Liver and intrahepatic bile ducts - tumor > Miscellaneous > Grossing. This information is intended for physicians and ...
Objective of the study: Primary intrahepatic bile duct dilatation (IHBD) may present as a localized form, in which resection of ... laparoscopic Liver Resection for Localized Primary Intrahepatic Bile Duct Dilatation. LAPAROSCOPIC LIVER RESECTION FOR ... LOCALIZED PRIMARY INTRAHEPATIC BILE DUCT DILATATION. Ibrahim DAGHER, Papa Saloum DIOP, Alessio CARLONI, Panagiotis LAINAS, ... It also allows a safe and efficient exploration of the common bile duct. We present here our results concerning the feasibility ...
Primary follicular lymphoma of extrahepatic bile duct End of Liver and intrahepatic bile ducts - tumor > Leukemia / lymphoma > ... Liver and intrahepatic bile ducts - tumor. Leukemia / lymphoma. Follicular lymphoma. Reviewers: Deepali Jain, M.D. (see ...
Liver and intrahepatic bile ducts - tumor. Other malignancies. Kaposi s sarcoma (KS). Reviewers: Deepali Jain, M.D. (see ... End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Kaposi s sarcoma (KS). This information is intended for ...
Immunohistochemistry revealed low levels of TGF-beta 1 in normal intrahepatic bile duct epithelium. In contrast, the bile duct ... These pathogenic responses were induced in rats by common bile duct ligation. Bile duct cell replication, measured by the ... termination of the bile duct epithelial cell proliferative response and the induction of fibrogenesis after common bile duct ... during intrahepatic bile duct hyperplasia and biliary fibrosis. ... Bile Ducts, Intrahepatic/pathology*. *Common Bile Duct/surgery ...
Secondary malignant neoplasm of liver and intrahepatic bile duct. 2016 2017 2018 2019 2020 Billable/Specific Code ... C22 Malignant neoplasm of liver and intrahepatic bile ducts* C22.0 Liver cell carcinoma ... secondary malignant neoplasm of liver and intrahepatic bile duct (. ICD-10-CM Diagnosis Code C78.7 ...
3-Dimensional Resin Casting and Imaging of Mouse Portal Vein or Intrahepatic Bile Duct System. J. Vis. Exp. (68), e4272, doi: ... 3-Dimensional Resin Casting and Imaging of Mouse Portal Vein or Intrahepatic Bile Duct System. J. Vis. Exp. (68), e4272, doi: ... Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis. Model ... 3-Dimensional Resin Casting and Imaging of Mouse Portal Vein or Intrahepatic Bile Duct System. J. Vis. Exp. (68), e4272, doi: ...
"시각화 및 마우스 간문맥 정맥 또는 intrahepatic의 담즙 덕트의 3 차원 구조를 정량화하는 방법이 설명되어 있습니다. 이 수지 주조 기술은 다른 ductal이나 혈관 시스템에 적용이 가능 할 수 있습니다... ... 시각화 및 마우스 간문맥 정맥 또는 intrahepatic의 담즙 덕트의 3 차원 구조를 정량화하는 방법이 설명되어 있습니다. 이 수지 주조 기술은 다른 ductal이나 혈관 시스템에 적용이 가능 할 수 있습니다 ... 3 차원 수지 주조 및 마우스 포털 정맥 또는 Intrahepatic의 담즙 덕트 시스템의 이미징 ... 3 차원 수지 주조 및 마우스 포털 정맥 또는 Intrahepatic의 담즙 덕트 시스템의 이미징 ...
Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines. ... Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines. ... Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from ... a part in the pathogenesis of immune mediated disorders such as primary biliary cirrhosis in which immune mediated bile duct ...
Start fundraising to fight Liver And Intrahepatic Bile Duct in Bellair-Meadowbrook Terrace today. No technical skill required, ... 2013 it is estimated that 22,720 men will be diagnosed with Liver and Intrahepatic Bile Duct. Liver and Intrahepatic Bile Duct ... 2013 it is estimated that 7,921 women will be diagnosed with Liver and Intrahepatic Bile Duct. Liver and Intrahepatic Bile Duct ... Liver and Intrahepatic Bile Duct Risks In A Lifetime Based on rates from 2008-2010, 0.86% of men and women born today will be ...
In this procedure, a lot of mucus was seen within the common bile duct and left intrahepatic bile duct. No bile duct stones ... Unenhanced nodules were seen within the left intrahepatic bile duct. Ultrasonography revealed intrahepatic and extrahepatic ... Abdominal enhanced computed tomography scan showed intrahepatic and extrahepatic bile duct dilatation with liver atrophy of ... Laparoscopic Anatomical Left Hepatectomy for Intrahepatic Bile Duct Papillary Mucinous Cystadenoma With Intraoperative Vascular ...
Alagille syndrome: from atresia of the intrahepatic bile ducts to the signaling pathway for Notch proteins] Michelle Hadchouel ... Alagille syndrome: from atresia of the intrahepatic bile ducts to the signaling pathway for Notch proteins]. Archives de ...
When biliary calculi are located in a duct adjacent to the duct cannulated percutaneously, obtaining wire and catheter access ... Once the duct containing the biliary calculi is accessed, sweeps of the calculi can be performed. ... the target duct may be difficult due to the acute angles required of the wire and catheter to access the stone-containing duct ... involves inflating a balloon catheter downstream from the origin of the target duct to deflect a wire into the target duct and ...
Intrahepatic Bile Duct Tumours The most common tumour of the intrahepatic bile ducts is intrahepatic cholangiocarcinoma. A much ... Intrahepatic Cholangiocarcinoma. Bile duct tumours occur within the liver and in the extrahepatic bile ducts. They are ... If there is occlusion of the large bile ducts then cholangitis may occur. Occlusion of the common bile duct leads to jaundice ... Intrahepatic Bile Duct Tumours Welcome » Basic Topics » Pathology » H: Gastrointestinal Malignancy » Hepatic Cancer » ...
Intrahepatic bile ducts[edit]. AJCC 7th Edition (2009) Note: New staging category beginning with the 7th edition. In prior ... N1 - regional lymph node metastasis (along the cystic duct, common bile duct, hepatic artery, and portal vein) ... Right liver (segments 5-8) - hilar (common bile duct, hepatic artery, portal vein, and cystic duct), periduodenal, ... Extrahepatic bile ducts[edit]. Current staging[edit]. AJCC 7th Edition (2009) For the 7th Edition staging, there are now ...
Bile duct cancer is relatively uncommon in the United States, with about 10,000 cases diagnosed each year, mostly in people ... the incidence of intrahepatic bile duct cancer is increasing.. Extrahepatic bile duct cancers. These diseases occur in bile ... Perihilar bile duct cancer: Perihilar bile duct cancer is the most common type of extrahepatic bile duct cancer. It occurs at ... of all bile duct cancer cases. Twenty to 30% originate in the lower bile duct, and about 10% arise in bile ducts within the ...
... by using a combination of extracorporeal shock wave lithotripsy and direct ... peroral cholangioscopy. This video demonstrates the successful removal of intrahepatic… ... A 50-year-old gentleman presented with multiple left intrahepatic duct (LIHD) and common bile duct (CBD) stones. At ERCP, ... Successful removal of intrahepatic bile duct stones. On December 26, 2014. February 4, 2015. By giejournalIn VideoGIE ...
Intrahepatic Bile Ducts. * Intrahepatic Bile Ducts Pages 56-127 * Extrahepatic Bile Duct. * Extrahepatic Bile Duct ... Bile Ducts Magnetic Resonance Imaging (MRI) Pancreatic Duct Tumor diagnosis imaging Authors and affiliations. *Lieven Van Hoe*1 ...
bile duct cancer. Cellular Classification of Bile Duct Cancer. intrahepatic bile duct cancer. Intrahepatic Bile Duct Cancer. ... bile duct cancerextrahepatic bile duct cancerintrahepatic bile duct cancerperihilar bile duct cancerdistal bile duct cancer. ... Intrahepatic bile duct. The bile ducts located within the liver are called intrahepatic bile ducts. Tumors of the intrahepatic ... bile duct cancerperihilar bile duct cancerdistal bile duct cancer. Stage Information for Bile Duct Cancer. Staging for Bile ...
Ana Rodríguez 0 Comments Alagille syndrome, bile, bile tree, cholestasis, intrahepatic bile ducts, JAG1, liver, Notch signaling ... intrahepatic bile ducts From The Labs Sox9 reshapes the biliary tree in Alagille syndrome October 10, 2019. October 10, 2019. ...
Find the survival rates for bile duct cancer here. ... Survival rates of bile duct cancer are based on outcomes of ... They are divided into intrahepatic and extrahepatic bile duct cancers.. Intrahepatic bile duct cancers (those starting within ... Extrahepatic bile duct cancers (those starting outside the liver). (This includes both perihilar and distal bile duct cancers.) ... 5-year relative survival rates for bile duct cancer. These numbers are based on people diagnosed with cancers of the bile duct ...
Clinical Pearl is a Continuous professional development platform with a precise and concise point of care clinical knowledge search engine and 360-degree learning cycle management platform for all healthcare professionals and organizations ...
Liver and intrahepatic bile duct cancer represents 2. The percent of liver and intrahepatic bile duct cancer deaths is highest ... For liver and intrahepatic bile duct cancer, The rate of new cases of liver and Seef bile duct cancer was 9. Glossary of ... Liver and intrahepatic bile duct cancer is the sixth leading cause of cancer death in the United States. No two patients are ... For liver and intrahepatic bile duct cancer, % are diagnosed at the local The 5-year relative survival for localized liver and ...
A bile duct is a tube that carries bile (fluid made by the liver that helps digest fat) between the liver and gallbladder and ... Bile duct cancer is cancer that forms in a bile duct. ... Study offers new hope for patients with intrahepatic ... Bile Duct Cancer Prognosis. Read More Causes of Bile Duct Cancer. Read More Bile Duct Cancer - Cholangiocarcinoma. Read More ... Bile Duct Cancer. Test for Bile Duct Cancer Bile duct cancer is identified, diagnosed, and staged with the help of tests that ...
Malignant neoplasm of liver and intrahepatic bile ducts, number of deaths, by sex, Categories: Cancer mortality ... Malignant neoplasm of liver and intrahepatic bile ducts Deaths(#), Malignant neoplasm of liver and intrahepatic bile ducts. ... Indicator full name: Malignant neoplasm of liver and intrahepatic bile ducts, number of deaths, by sex ... Malignant neoplasm of liver and intrahepatic bile ducts, number of deaths, female (Line chart) ...
Right trisectionectomy of the liver for intrahepatic cholangiocarcinoma with bile duct invasion in a Jehovahs Witness. Journal ... Right trisectionectomy of the liver for intrahepatic cholangiocarcinoma with bile duct invasion in a Jehovahs Witness. / ... title = "Right trisectionectomy of the liver for intrahepatic cholangiocarcinoma with bile duct invasion in a Jehovahs Witness ... T1 - Right trisectionectomy of the liver for intrahepatic cholangiocarcinoma with bile duct invasion in a Jehovahs Witness ...
  • The most common tumour of the intrahepatic bile ducts is intrahepatic cholangiocarcinoma . (wikidot.com)
  • In these populations, intrahepatic cholangiocarcinoma makes up close to 90% of liver malignancies with an incidence of 85 per 100,000. (wikidot.com)
  • Historically, patients exposed to Thoratrast in the 1930s and 40s had an increased risk of intrahepatic cholangiocarcinoma. (wikidot.com)
  • An uncommon variant is the intraductal papillary cholangiocarcinoma which demonstrates minimal invasion but grows along multiple bile ducts. (wikidot.com)
  • Cancer of the bile duct (also called cholangiocarcinoma) is extremely rare. (oncolink.org)
  • For example, if the 5-year relative survival rate for a specific stage of bile duct cancer (cholangiocarcinoma) is 30%, it means that people who have that cancer are, on average, about 30% as likely as people who don't have that cancer to live for at least 5 years after being diagnosed. (cancer.org)
  • Intrahepatic cholangiocarcinoma (ICC) is well known to have a very poor prognosis. (elsevier.com)
  • Incyte Corporation announces updated data from its ongoing Phase 2 FIGHT-202 trial evaluating pemigatinib (INCB54828), its selective fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced/metastatic or surgically unresectable cholangiocarcinoma (bile duct cancer) who failed at least one previous treatment. (news-medical.net)
  • Infection has been strongly linked to cholangiocarcinoma, or bile duct cancer, an uncommon but aggressive form of cancer. (news-medical.net)
  • A biopsy confirmed that she had intrahepatic cholangiocarcinoma, more commonly known as bile duct cancer. (news-medical.net)
  • A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, Fundeni Clinical Institute (Romania) and Koen Kaen University (Thailand), have made a seminal breakthrough in understanding the molecular basis of bile duct cancer or cholangiocarcinoma, a rare but highly lethal form of liver cancer. (news-medical.net)
  • Perihilar bile duct cancer is also called a Klatskin tumor or perihilar cholangiocarcinoma. (oncolink.org)
  • A 68-year-old Japanese female was being followed up for autoimmune hepatitis, and was referred to our hospital because segmental intrahepatic bile duct dilation was found on routine imaging studies, suggesting intrahepatic cholangiocarcinoma. (elsevier.com)
  • Fortunes turn for Mr. Manzarek, as he passes away from cholangiocarcinoma , bile duct cancer , a rare cancer that afflicts less than 4,000 people a year in the U.S. (medicinenet.com)
  • In summary, we encountered a case of lower bile duct metastasis from rectal cancer, which is often difficult to differentiate from cholangiocarcinoma. (biomedcentral.com)
  • Intrahepatic cholangiocarcinoma develops from cholangiocytes (bile duct cells) located inside the liver. (bmc.org)
  • Intrahepatic cholangiocarcinoma accounts for 1 or 2 out of every 10 cases of liver cancer (American Cancer Society 2015). (bmc.org)
  • Characterization of gut microbiota, bile acid metabolism, and cytokines in intrahepatic cholangiocarcinoma. (bioportfolio.com)
  • cytokines in intrahepatic cholangiocarcinoma. (bioportfolio.com)
  • DLEC1 methylation is associated with a better clinical outcome in patients with intrahepatic cholangiocarcinoma of the small duct subtype. (bioportfolio.com)
  • Intrahepatic cholangiocarcinoma is a complex disease with three different histologic subtypes, the large duct, small duct, and bile ductular types. (bioportfolio.com)
  • The primary objective of this study is to estimate the frequency of FGFR2 fusions in archived intrahepatic cholangiocarcinoma (iCCA) or mixed hepatocellular-cholangiocarcinoma (HCC-CCA) tu. (bioportfolio.com)
  • Intrahepatic cholangiocarcinoma (ICC) is one of the most common liver malignancies. (bioportfolio.com)
  • Objective of the study: Primary intrahepatic bile duct dilatation (IHBD) may present as a localized form, in which resection of the affected liver can prevent immediate and late complications. (sages.org)
  • Abdominal enhanced computed tomography scan showed intrahepatic and extrahepatic bile duct dilatation with liver atrophy of left lobe. (ovid.com)
  • Ultrasonography revealed intrahepatic and extrahepatic bile duct dilatation with viscous fluid, tubular adenoma? (ovid.com)
  • However, CT scan at the time of admission showed common bile duct (CBD) stenosis, proximal biliary dilatation and bile lake formation at the segment II and III. (bvsalud.org)
  • No significant correlation was observed between individual cytokine gene polymorphisms and intrahepatic duct dilatation (IHDD). (cdc.gov)
  • Ultrasound and computed tomography demonstrated dilatation of the left intra-hepatic bile ducts. (biomedcentral.com)
  • Ciliopathies involving PCK cholangiocytes (cholangiociliopathies) in a rat model appear to be associated with decreased intracellular calcium levels and increased cAMP concentrations, causing cholangiocyte hyperproliferation, abnormal cell matrix interactions, and altered fluid secretion, which ultimately result in bile duct dilatation. (medscape.com)
  • Mild intrahepatic biliary duct dilatation. (healthtap.com)
  • We do not know why the scan was ordered but mild intrahepatic biliary duct dilatation may be completely normal for this patient. (healthtap.com)
  • What does diffuse dilatation of common bile duct & mild dilatation of hepatic ducts mean? (healthtap.com)
  • Caroli disease is a rare inherited disorder characterized by abnormal widening (dilatation) of the ducts that carry bile from the liver (intrahepatic bile ducts). (rarediseases.org)
  • In most cases, the isolated or simple form is characterized by widening of the bile ducts (dilatation or ectasia). (rarediseases.org)
  • The hilum is the region where the right and left hepatic ducts exit the liver and join to form the common hepatic duct that is proximal to the origin of the cystic duct. (oncolink.org)
  • The cystic duct connects the gallbladder to the common hepatic duct. (oncolink.org)
  • Bile from the liver passes through the hepatic ducts, common hepatic duct, and cystic duct and is stored in the gallbladder. (oncolink.org)
  • When food is being digested, bile stored in the gallbladder is released and passes through the cystic duct to the common bile duct and into the small intestine. (oncolink.org)
  • Bile is made in the liver and flows through the common hepatic duct and the cystic duct to the gallbladder, where it is stored. (oncolink.org)
  • Cystic duct , 6. (wikipedia.org)
  • The cystic duct is the short duct that joins the gallbladder to the common bile duct . (wikipedia.org)
  • Gallstones can enter and obstruct the cystic duct, preventing the flow of bile. (wikipedia.org)
  • During a cholecystectomy , the cystic duct is clipped two or three times and a cut is made between the clips, freeing the gallbladder to be taken out. (wikipedia.org)
  • Cystic duct.Visceral surface of liver. (wikipedia.org)
  • Gall bladder and removal of stone at the junction of cystic duct and cbd via open surgery. (healthtap.com)
  • The common hepatic duct in turn joins the cystic duct coming from the gall bladder to form the common bile duct. (medindia.net)
  • It forms one edge of Calot's triangle , along with the cystic duct and the cystic artery . (wikipedia.org)
  • Perihilar bile duct cancer is the most common type of extrahepatic bile duct cancer. (mdanderson.org)
  • Extrahepatic Bile Duct Cancer Clinical Trials. (medicinenet.com)
  • After a person is diagnosed with intrahepatic bile duct cancer, doctors will try to figure out if it has spread, and if so, how far. (cancer.org)
  • Intrahepatic bile duct cancer is typically given a clinical stage based on the results of a physical exam, biopsy, and imaging tests (described in Tests for Bile Duct Cancer ). (cancer.org)
  • In 2015, 32,908 new liver and intrahepatic bile duct cancer cases and 25,760 deaths were reported in the United States. (cdc.gov)
  • dIn 2013, it is estimates from the National Cancer Institute where Liver and Intrahepatic Bile Duct has a diagnosis rate of 0.8. (donationto.com)
  • It is estimated that 30,640 men and women (22,720 men and 7,920 women) will be diagnosed with and 21,670 men and women will die of cancer of the liver and intrahepatic bile duct in 2013. (donationto.com)
  • From 2006-2010, the median age at diagnosis for cancer of the liver and intrahepatic bile duct was 63 years of age. (donationto.com)
  • Based on rates from 2008-2010, 0.86% of men and women born today will be diagnosed with cancer of the liver and intrahepatic bile duct at some time during their lifetime. (donationto.com)
  • This number can also be expressed as 1 in 117 men and women will be diagnosed with cancer of the liver and intrahepatic bile duct during their lifetime. (donationto.com)
  • Since most bile duct cancers are diagnosed in more advanced stages, the current five-year survival rate is only 10% to 30%, depending upon the type of cancer. (mdanderson.org)
  • Bile duct cancer can be divided into two main categories: Intrahepatic and extrahepatic. (mdanderson.org)
  • This cancer occurs in the bile ducts that are within the liver. (mdanderson.org)
  • Although uncommon, the incidence of intrahepatic bile duct cancer is increasing. (mdanderson.org)
  • These tumors account for 40 to 60% of all bile duct cancer cases. (mdanderson.org)
  • There are several medical conditions that increase the risk for bile duct cancer, which is typically found in the older population. (mdanderson.org)
  • Ethnicity: Bile duct cancer is much more common in Asian countries, where a liver parasite is common. (mdanderson.org)
  • Excessive consumption of alcohol increases the risk of bile duct cancer, especially among people who have alcohol-associated liver damage. (mdanderson.org)
  • Why choose MD Anderson for bile duct cancer treatment? (mdanderson.org)
  • Learn about the types of bile duct cancer, risk factors, clinical features, staging, and treatment for bile duct cancer in this expert-reviewed summary. (oncolink.org)
  • This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of bile duct cancers. (oncolink.org)
  • The true incidence of bile duct cancer is unknown, however, because establishing an accurate diagnosis is difficult. (oncolink.org)
  • In contrast, bile duct tumors located outside of the liver had been classified with gallbladder cancer as extrahepatic biliary tract tumors. (oncolink.org)
  • Bile duct cancer may occur more frequently in patients with a history of primary sclerosing cholangitis, chronic ulcerative colitis, choledochal cysts, or infections with the liver fluke Clonorchis sinensis. (oncolink.org)
  • Intrahepatic bile duct cancer may be relatively indolent and difficult to clinically differentiate from metastatic adenocarcinoma deposits in the liver. (oncolink.org)
  • The SEER database tracks 5-year relative survival rates for bile duct cancer in the United States, based on how far the cancer has spread. (cancer.org)
  • There is no sign that the cancer has spread outside of the bile ducts. (cancer.org)
  • The cancer has spread outside the bile ducts to nearby structures or lymph nodes. (cancer.org)
  • The percent of liver and intrahepatic bile duct cancer deaths is highest among people aged 55- The death rate was 6. (stylin-on.me)
  • Liver and intrahepatic bile duct cancer is the sixth leading cause of cancer death in the United States. (stylin-on.me)
  • For liver and intrahepatic bile duct cancer, The rate of new cases of liver and Seef bile duct cancer was 9. (stylin-on.me)
  • Find album reviews, stream songs, credits and award information for Seer Live: Open Air in Grundlsee - Die Seer on AllMusic - The earlier liver and intrahepatic bile duct cancer is caught, the better chance a person has of surviving five years after being diagnosed. (stylin-on.me)
  • Bile duct cancer is identified, diagnosed, and staged with the help of tests that analyze bile ducts and neighboring organs. (news-medical.net)
  • Treatment of patients suffering from bile duct cancer could be improved by tailoring medication to the levels of a key protein in people with the disease, according to new research. (news-medical.net)
  • For the first time, researchers at the George Washington University, together with colleagues at institutes in Thailand, Australia, the U.K. and the Netherlands, and more, have successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for schistosomiasis and for liver fluke infection, which can cause a diverse spectrum of human disease including bile duct cancer. (news-medical.net)
  • After Keith Beck died of bile duct cancer last year, family members said more than 900 people showed up to pay respects to the popular athletic director at the University of Findlay in northwestern Ohio. (news-medical.net)
  • The Virginia G. Piper Cancer Center at Scottsdale Healthcare and the Translational Genomics Research Institute are studying the safety and effectiveness of a new drug, AG-120, for treatment of patients with solid tumors, especially those with brain tumors and gallbladder bile duct cancer. (news-medical.net)
  • Darren Carpizo, MD, PhD, a surgical oncologist in the Liver Cancer and Bile Duct Cancer Care Program at the Cancer Institute of New Jersey, has been awarded a $200,000 grant from the Sidney Kimmel Foundation for Cancer Research to further explore the effects of a compound identified in his laboratory found to restore tumor suppressor function of a mutated gene in cancer cells. (news-medical.net)
  • A rare type of cancer thought to derive from cells in the bile ducts of the liver may actually develop when one type of liver cell morphs into a totally different type, a process scientists used to consider all but impossible. (news-medical.net)
  • Expert-reviewed information summary about the treatment of bile duct cancer. (oncolink.org)
  • This PDQ cancer information summary has current information about the treatment of bile duct cancer. (oncolink.org)
  • Bile duct cancer is a rare disease in which malignant (cancer) cells form in the bile ducts. (oncolink.org)
  • Having colitis or certain liver diseases can increase the risk of bile duct cancer. (oncolink.org)
  • Signs of bile duct cancer include jaundice and pain in the abdomen. (oncolink.org)
  • Tests that examine the bile ducts and nearby organs are used to detect (find), diagnose, and stage bile duct cancer. (oncolink.org)
  • Different procedures may be used to obtain a sample of tissue and diagnose bile duct cancer. (oncolink.org)
  • This type of cancer forms in the bile ducts inside the liver. (oncolink.org)
  • This type of cancer is found in the hilum region, the area where the right and left bile ducts exit the liver and join to form the common hepatic duct. (oncolink.org)
  • The most common subtypes are hepatocellular carcinoma (ICD10 C22.0, cancer occurring in the liver cells), and intrahepatic bile duct carcinoma (ICD10 C22.1, cancer originating in the sections of bile ducts that are inside the liver). (ncin.org.uk)
  • Intrahepatic bile duct carcinoma is the second most common primary liver cancer subtype and the causes of this cancer are unclear. (ncin.org.uk)
  • These and other signs and symptoms may be caused by bile duct cancer or by other conditions. (cancer.gov)
  • Procedures that make pictures of the bile ducts and the nearby area help diagnose bile duct cancer and show how far the cancer has spread. (cancer.gov)
  • The process used to find out if cancer cells have spread within and around the bile ducts or to distant parts of the body is called staging . (cancer.gov)
  • In order to plan treatment, it is important to know if the bile duct cancer can be removed by surgery . (cancer.gov)
  • Tests and procedures to detect, diagnose, and stage bile duct cancer are usually done at the same time. (cancer.gov)
  • home / what is the survival rate for bile duct cancer? (medicinenet.com)
  • For bile duct cancers, quantity (how long people live and how long they can survive), depends upon exactly where in the bile duct the cancer is located. (medicinenet.com)
  • If the cancer begins in the duct after it has left the liver on the way to the intestine, survival is marginally better. (medicinenet.com)
  • The more the cancer spreads beyond the bile duct, to tissue and lymph nodes , the tougher the cancer is to beat. (medicinenet.com)
  • Further, lower bile duct metastasis of colorectal cancer is rare. (biomedcentral.com)
  • We report the case of a 74-year-old woman who underwent pylorus-preserving pancreatoduodenectomy for lower bile duct metastasis of rectal cancer. (biomedcentral.com)
  • The patient had undergone laparoscopic low anterior resection for rectal cancer (pT3N0M0 stage IIA) 6 years ago, laparoscopic anterior liver resection for liver metastasis (Couinaud segment V) 3 years ago, and left and caudal lobectomy with extrahepatic bile duct resection for left intrahepatic bile duct metastasis 6 months ago. (biomedcentral.com)
  • A few cases of lower bile duct metastasis from colorectal cancer have been reported. (biomedcentral.com)
  • Here, we report a case of lower bile duct metastasis from rectal cancer for which pylorus-preserving pancreatoduodenectomy was performed. (biomedcentral.com)
  • Cancer of the bile duct outside of the liver is much more common. (medlineplus.gov)
  • Tests to diagnose bile duct cancer may include a physical exam, imaging tests of the liver and bile ducts, blood tests, and a biopsy. (medlineplus.gov)
  • How Is Bile Duct Cancer Diagnosed? (medlineplus.gov)
  • What Happens After Treatment for Bile Duct Cancer? (medlineplus.gov)
  • Do We Know What Causes Bile Duct Cancer? (medlineplus.gov)
  • What Are the Risk Factors for Bile Duct Cancer? (medlineplus.gov)
  • What Are the Key Statistics about Bile Duct Cancer? (medlineplus.gov)
  • Cancer of the bile ducts inside and outside the liver, gall bladder cancer liver and prostate gland cancers . (medindia.net)
  • Bile duct cancer starts in the bile ducts, which are thin tubes between the liver and the small intestine. (cancertutor.com)
  • Bile duct cancer can affect your body in many ways. (cancertutor.com)
  • Bile duct cancer does not usually cause signs or symptoms until later in the course of the disease, but sometimes symptoms can appear sooner and lead to an early diagnosis. (cancertutor.com)
  • The average age of people diagnosed with cancer of the intrahepatic bile ducts (within or originating in the liver) is 70, and for cancer of the extrahepatic bile ducts (situated or originating outside the liver), it is 72. (cancertutor.com)
  • Bile duct cancer is more common in men (13 cases per 100,000 people) than women (4.4), and among Asian / Pacific Islander (20.8 for men), Hispanic (19.5) and American Indian / Alaska Native (18.5) populations. (cancertutor.com)
  • The Cellect-Budwig Protocol is recommended for bile duct cancer because it is a good detox protocol. (cancertutor.com)
  • Distal lesions of smaller bile ducts may cause minimal symptoms until the tumour has progressed to a large size, whereas those arising more proximally in the central bile ducts may cause early jaundice and sepsis. (wikidot.com)
  • The bile ducts distal to the lesion are usually dilated (in contrast to hepatocellular carcinoma which rarely invades bile ducts). (wikidot.com)
  • The classification of bile duct tumors has changed to include intrahepatic tumors of the bile ducts and extrahepatic tumors (perihilar and distal) of the bile ducts. (oncolink.org)
  • The extrahepatic bile ducts can be further divided into the perihilar (hilum) region and distal region. (oncolink.org)
  • The extrahepatic bile duct is made up of the hilum region and the distal region. (oncolink.org)
  • The distal region is made up of the common bile duct which passes through the pancreas and ends in the small intestine. (oncolink.org)
  • They are made up of the common hepatic duct (hilum region) and the common bile duct (distal region). (oncolink.org)
  • [ 55 ] This procedure implies excision of the distal common bile duct (CBD). (medscape.com)
  • GB like symptoms.US-distal dilation of CBD 7.7mm.MRCP-mild prominence of pancreatic duct.Dense adhesions between GB & abdominal wall. (healthtap.com)
  • Microscopic examination of the explanted liver showed a primary composite tumor comprising small cell and mucinous carcinomas that originated in the intrahepatic bile duct. (elsevier.com)
  • The surgical findings showed no tumor around the bile duct but rather a 2 cm cyst in segment four of Couinaud's category of the liver around the hilum. (biomedcentral.com)
  • The earliest stage intrahepatic bile duct cancers are stage 0 (also called carcinoma in situ, or CIS) . (cancer.org)
  • It's used only for intrahepatic bile duct cancers (those starting within the liver). (cancer.org)
  • Cancers of the bile ducts are relatively uncommon in the United States. (mdanderson.org)
  • In the U.S., Native Americans and Hispanics are more likely to get bile duct cancers. (mdanderson.org)
  • Many bile duct cancers are multifocal. (oncolink.org)
  • These numbers are based on people diagnosed with cancers of the bile duct between 2009 and 2015. (cancer.org)
  • They are divided into intrahepatic and extrahepatic bile duct cancers. (cancer.org)
  • Only a small number of bile duct cancers are intrahepatic . (oncolink.org)
  • Intrahepatic bile duct cancers are also called intrahepatic cholangiocarcinomas. (oncolink.org)
  • Bile duct cancers hide deep within the abdomen, hidden by the bulk of the liver, and are largely unable to be detected. (medicinenet.com)
  • Nearly all bile duct cancers are called cholangiocarcinomas (composed of mutated epithelial cells). (cancertutor.com)
  • Researchers do not know the exact cause of most bile duct cancers. (cancertutor.com)
  • However, there seems to be a link between these cancers and things that irritate and inflame the bile ducts - bile duct stones, choledochal cysts, parasites, cirrhosis of the liver, or something else. (cancertutor.com)
  • There is no known way to prevent most bile duct cancers. (cancertutor.com)
  • Many of the known risk factors for bile duct cancers, such as age, ethnicity, and bile duct abnormalities, are beyond our control. (cancertutor.com)
  • If there is occlusion of the large bile ducts then cholangitis may occur. (wikidot.com)
  • These symptomatic SNHCs are usually larger than 10 cm and can cause obstructive jaundice and cholangitis because of their mass effect on the bile ducts. (biomedcentral.com)
  • Usually a gallstone causing obstruction of the common bile duct can cause sudden painful jaundice , sometimes with associated cholangitis (infection of the bile) This requires drainage and extraction of the stone from the common bile duct with a procedure call ERCP . (healthtap.com)
  • In addition, bile duct stones, surgery, parasites or drugs are responsible for some cases of sclerosing cholangitis. (medindia.net)
  • 1. Primary sclerosing cholangitis (PSC) is a chronic liver condition characterized by inflammation and scarring of bile ducts within and outside of the liver. (medindia.net)
  • 2. Secondary Sclerosing Cholangitis (SSC) is a similar condition where the bile ducts are inflamed, leading to scarring and narrowing of the ducts. (medindia.net)
  • RESULTS: During a follow-up period ranging from 4 months to 17 years (mean, 8.5 years), anastomotic stricture, cholangitis, and intrahepatic stone formation developed in two children after being well for 8 years and over 11 years. (biomedsearch.com)
  • Complications of bile-duct stones: Acute cholangitis and pancreatitis. (medscape.com)
  • Three patients had associated common bile duct stones which were treated through perioperative cholangioscopy. (sages.org)
  • No bile duct stones were found after the exploration. (ovid.com)
  • Syed Mujahid Hassan, FCPS and colleagues from the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Civil Hospital Karachi, in Karachi, Pakistan present this video case "Successful removal of intrahepatic bile duct stones by using a combination of extracorporeal shock wave lithotripsy and direct peroral cholangioscopy. (endoscopedia.com)
  • This video demonstrates the successful removal of intrahepatic bile duct stones using a combination of 2 novel techniques, that is, extra-corporeal shock wave lithotripsy and direct per-oral cholangioscopy (DPC). (endoscopedia.com)
  • A 50-year-old gentleman presented with multiple left intrahepatic duct (LIHD) and common bile duct (CBD) stones. (endoscopedia.com)
  • 37 Cholecystolithiasis and Stones in the Common Bile Duct: Which Approach and When? (elsevier.com)
  • Patients with Caroli disease or Caroli syndrome may have a history of intermittent abdominal pain, which reflects episodes of bile stasis or the passage of bile stones. (medscape.com)
  • you still can form stones within the common bile duct. (healthtap.com)
  • There may also be localized accumulation of pus (abscess), stones that develop inside the bile ducts (intraductal lithiasis), abdominal pain, and/or fever. (rarediseases.org)
  • Asymptomatic intrahepatic stones 2 years after cyst excision with hepaticojejunostomy developed in a third child. (biomedsearch.com)
  • Interlobar ducts (between the main hepatic ducts and the interlobular ducts) - pseudostratified columnar epithelium. (wikipedia.org)
  • Karakousis CP, Douglass HO (1977) Hilar hepatojejunostomy in resection of carcinoma of the main hepatic duct junction. (springer.com)
  • Traditionally, bile duct tumors located within the liver had been classified with hepatocellular carcinoma as primary liver tumors. (oncolink.org)
  • Intraductal papillary neoplasm of bile duct (IPNB) is characterized by a spectrum of diseases ranging from low-grade intraepithelial neoplasia to invasive carcinoma. (cdc.gov)
  • Consequently, it blocks the reflux of pancreatic enzymes into the biliary tract, thereby decreasing the incidence of carcinoma of the bile duct. (medscape.com)
  • Hepatocellular carcinoma is more common in men whereas intrahepatic bile duct carcinoma is more common in women. (ncin.org.uk)
  • Hepatocellular carcinoma (ICD10 C22.0) and intrahepatic bile duct carcinoma (ICD10 C22.1) were the largest subtypes (Table 1). (ncin.org.uk)
  • Age-standardised incidence rates per 100,000 European standard population (ASR(E)), were calculated for men and women, for hepatocellular carcinoma (C22.0) and intrahepatic bile duct carcinoma (C22.1), by year of diagnosis. (ncin.org.uk)
  • Hepatocellular carcinoma is the most common subtype in men but intrahepatic bile duct carcinoma is the largest subtype in women. (ncin.org.uk)
  • 1990) Left hepatic duct anatomy: implications. (springer.com)
  • They include part of the right and left hepatic ducts that are outside the liver, the common hepatic duct, and the common bile duct. (oncolink.org)
  • The two ducts join outside the liver and form the common hepatic duct . (oncolink.org)
  • cholangiography confirmed total obstruction of the main bifurcation of the hepatic duct by intraductal tumour growth . (lookfordiagnosis.com)
  • Common hepatic duct , 5. (wikipedia.org)
  • Bile can flow in both directions between the gallbladder and the common bile duct and the hepatic duct . (wikipedia.org)
  • Anatomical variation in IHDs was classified according to the branching pattern of the right anterior and right posterior segmental duct (RASD and RPSD, respectively), and the presence or absence of the first-order branch of the left hepatic duct (LHD), and of an accessory hepatic duct . (bvsalud.org)
  • A very small solitary hepatic cyst might cause hepatic duct stricture if it is located near the hepatic hilum, and should be considered in the differential diagnosis of a hepatic duct stricture. (biomedcentral.com)
  • In this case, we present a 70-year-old man with a very small (2 cm) cyst in the hepatic hilum compressing the left hepatic duct. (biomedcentral.com)
  • We performed a left hepatectomy on July 11, 2007 because we could not exclude a malignancy of the left hepatic duct. (biomedcentral.com)
  • Together they form the common hepatic duct. (medindia.net)
  • As they descend from the liver, they unite to form the common hepatic duct. (healthline.com)
  • The biliary duct, or the duct from the gallbladder, also opens into the common hepatic duct. (healthline.com)
  • The common hepatic duct is the part of the biliary tract formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). (wikipedia.org)
  • The hepatic duct is part of the biliary tract that transports secretions from the liver into the intestines . (wikipedia.org)
  • The common hepatic duct is about 6mm in diameter in adults, with some variation. (wikipedia.org)
  • 16. Accessory pancreatic duct , 17. (wikipedia.org)
  • As a part of the digestive system, it functions as an exocrine gland secreting pancreatic juice into the duodenum through the pancreatic duct . (wikipedia.org)
  • Two ducts, the main pancreatic duct and a smaller accessory pancreatic duct , run through the body of the pancreas, joining with the common bile duct near a small ballooning called the ampulla of Vater . (wikipedia.org)
  • Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines. (bmj.com)
  • Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from normal livers and established in primary culture. (bmj.com)
  • These data show that pro-inflammatory cytokines increase expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on human intrahepatic biliary epithelial cells in vitro and are consistent with the hypothesis that these locally acting factors may play a part in the pathogenesis of immune mediated disorders such as primary biliary cirrhosis in which immune mediated bile duct damage occurs. (bmj.com)
  • Primitive biliary cells are known to migrate from the ductal plate into the mesenchyme during human intrahepatic bile duct development, and this migration process is essential for normal development of intrahepatic bile ducts. (elsevier.com)
  • In this study, we therefore investigated in situ expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) during human intrahepatic bile duct development, using 32 human fetal livers. (elsevier.com)
  • These data suggest that MMP, trypsinogen/trypsin, chymotrypsinogen/chymotrypsin, and cathepsin B play a critical role in biliary cell migration during human intrahepatic bile duct development by degrading extracellular matrix proteins. (elsevier.com)
  • The coordinated expression of MMP, MMP inhibitors, and MMP activators may be necessary for the normal development of human intrahepatic bile ducts. (elsevier.com)
  • Terada, T, Okada, Y & Nakanuma, Y 1995, ' Expression of matrix proteinases during human intrahepatic bile duct development: A possible role in biliary cell migration ', American Journal of Pathology , vol. 147, no. 5, pp. 1207-1213. (elsevier.com)
  • Today the median age of diagnosis for Liver and Intrahepatic Bile Duct is 63. (donationto.com)
  • Postoperative pathological diagnosis was intrahepatic bile duct papillary mucinous cystadenoma. (ovid.com)
  • This book, the proceedings of the Falk Symposium 107 on `Diseases of the Liver and the Bile Ducts - New Aspects and Clinical Implications', held in Prague, Czech Republic, on April 30-May 2, 1998, brings together scientists and clinicians to highlight the most recent advances in molecular biology, physiology, diagnosis and therapy of diseases of the biliary system. (bookdepository.com)
  • Cremer A, Arvanitakis M. Diagnosis and management of bile stone disease and its complications. (medscape.com)
  • In this study, we identified new biomarkers, including gut microbiota, bile acids, and inflammatory cytokines, for diagnosis of ICC and prediction of VI in patients with ICC. (bioportfolio.com)
  • A biliary obstruction is a blockage of the bile ducts . (healthline.com)
  • Obstruction of any of these bile ducts is referred to as a biliary obstruction. (healthline.com)
  • Cholestatic liver diseases leading to progressive destruction of intra-hepatic bile ducts and ductopenia encompass multiple etiologies. (lookfordiagnosis.com)
  • Endoscopic retrograde cholangiopancreatography showed that the right intra-hepatic bile ducts were normally filled with contrast medium, but the left intra-hepatic bile ducts were not seen in the confluence. (biomedcentral.com)
  • This showed a distended gallbladder with sludge in it and dilated intra-hepatic bile ducts (IHBD). (biomedcentral.com)
  • Bile travels through a number of small channels within the liver called intra-hepatic bile ducts . (medindia.net)
  • Cysts in the bile ducts (cysts block the flow of bile and can cause swollen bile ducts, inflammation, and infection ). (oncolink.org)
  • It contains ' spiral valves of Heister ', which do not provide much resistance to the flow of bile. (wikipedia.org)
  • Thus, the flow of bile from the liver to the intestine may be obstructed. (medindia.net)
  • Tumors of the intrahepatic bile ducts originate in small intrahepatic ductules or large intrahepatic ducts that are proximal to the bifurcation of the right and left hepatic ducts. (oncolink.org)
  • There are areas of mild narrowing & irregularity of the intrahepatic ducts & proximal common duct. (healthtap.com)
  • Risk factors include having inflammation of the bile duct, ulcerative colitis , and some liver diseases. (medlineplus.gov)
  • They can be divided into: Lobar ducts (right and left hepatic ducts) - stratified columnar epithelium. (wikipedia.org)
  • The small ducts come together to form the right and left hepatic ducts, which lead out of the liver. (oncolink.org)
  • Two years after undergoing hepatectomy, the follow-up CT scan revealed dilation of the left intrahepatic bile duct and a high-density mass in the common trunk of segment II and segment III (B23). (biomedcentral.com)
  • MRCP "Persistent mild dilation of the central intrahepatic duct. (healthtap.com)
  • No dilation of common bile duct. (healthtap.com)
  • It is often difficult to correctly diagnose patients who present with dilation of the bile duct. (bioportfolio.com)
  • We describe a Jehovah's Witness patient with ICC and concomitant bile duct invasion who had a successful right trisectionectomy with bile duct resection, lymph node dissection, and Rouxen-Y hepatico-jejunostomy without blood transfusion. (elsevier.com)
  • The patient had previously undergone laparoscopic low anterior resection, laparoscopic anterior liver resection, and left and caudal lobectomy with extrahepatic bile duct resection. (biomedcentral.com)
  • Therefore, she underwent left and caudal lobectomy with extrahepatic bile duct resection in April 2017. (biomedcentral.com)
  • Treatment of choledochal cysts is surgical, except for type V multiple intrahepatic cysts, which can benefit from medical management for variable periods of time. (medscape.com)
  • Total excision of the cyst in types I, II, and IV followed by reconstruction of the biliary tree with hepaticojejunostomy in a Roux-en-Y fashion has been widely accepted as the procedure of choice in treating choledochal cysts and has been found to be superior to hepaticoduodenostomy. (medscape.com)
  • This widening may occur as a result of the formation of fluid-filled sacs or lumps (choledochal cysts) in the bile ducts. (rarediseases.org)
  • He underwent excision of the CBD including the stricture site, and the bile duct was reconstructed with Roux-en-Y hepaticojejunostomy. (bvsalud.org)
  • Pathologic report of the resected specimen revealed that the evidence of trauma as a cause of bile duct stricture. (bvsalud.org)
  • It can happen in the parts of the bile ducts that are outside or inside the liver. (medlineplus.gov)
  • The smallest ducts, called ductules, come together to form the right hepatic bile duct and the left hepatic bile duct, which drain bile from the liver. (oncolink.org)
  • These tumors are also known as intrahepatic cholangiocarcinomas. (oncolink.org)
  • Bile duct epithelial cells, or cholangiocytes, proliferate in vivo under a number of pathologic (i.e., partial hepatectomy) and pathophysiologic (i.e., bile duct ligation, malignant transformation) conditions. (elsevier.com)
  • It also allows a safe and efficient exploration of the common bile duct. (sages.org)
  • These pathogenic responses were induced in rats by common bile duct ligation. (nih.gov)
  • Bile duct cell replication, measured by the bromodeoxyuridine labeling index, was significantly increased 24 hr after common bile duct ligation. (nih.gov)
  • Liver collagen content, determined by quantification of hydroxyproline, was increased significantly after 1 wk of common bile duct ligation, and by 4 wk was increased by a factor of 4. (nih.gov)
  • These results suggest that transforming growth factor-beta 1 may play a role in both the termination of the bile duct epithelial cell proliferative response and the induction of fibrogenesis after common bile duct ligation. (nih.gov)
  • Laparoscopic anatomical left hepatectomy and common bile duct exploration were performed. (ovid.com)
  • In this procedure, a lot of mucus was seen within the common bile duct and left intrahepatic bile duct. (ovid.com)
  • Occlusion of the common bile duct leads to jaundice and liver failure. (wikidot.com)
  • This region includes the common bile duct and inserts into the small intestine. (oncolink.org)
  • A follow-up examination showed a 15 mm mass in the common bile duct, for which she underwent pylorus-preserving pancreatoduodenectomy. (biomedcentral.com)
  • Paired ECO and ICO were derived from common bile duct and liver tissue, respectively. (rug.nl)
  • Status post cholecystectomy with prominent gastrohepatic common bile duct measuring 7mm means what? (healthtap.com)
  • The common bile duct diameter of 7mm is normal for your age. (healthtap.com)
  • The normal common bile duct finding means the liver, pancreas and gallbladder empty in to a normal duct that drains into the intestine . (healthtap.com)
  • The common bile duct finally opens into the first part of the intestine. (medindia.net)
  • The bile duct from this point onward is known as the common bile duct or choledochus. (healthline.com)
  • Before emptying into the small intestine, the common bile duct passes through the pancreas. (healthline.com)
  • Rohrmann CA, Ansel HJ, Ayoola EA, Silvis SE, Vennes JA (1977) Endoscopic retrograde intrahepatic cholangiogram: radiographic findings in intrahepatic disease. (springer.com)
  • These studies investigate the role of transforming growth factor-beta 1, a potent inhibitor of epithelial cell proliferation and stimulator of extracellular matrix biosynthesis, during intrahepatic bile duct hyperplasia and biliary fibrosis. (nih.gov)
  • Larusso, Nicholas F. / Characterization and growth regulation of a rat intrahepatic bile duct epithelial cell line under hormonally defined, serum-free conditions . (elsevier.com)
  • Bile is produced by the liver and is important for fat digestion. (oncolink.org)
  • The gall bladder normally stores the excessive bile produced by the liver. (medindia.net)
  • These cholangiocytes line the bile ducts, which facilitate excretion of bile produced by the liver. (bmc.org)
  • We have previously shown in both normal and bile duct-ligated (BDL) rats that cholangiocytes are morphologically heterogeneous with small cholangiocytes lining small bile ducts and large cholangiocytes lining large bile ducts ( 1 , 3 , 8 , 10 ). (physiology.org)
  • Primary biliary cirrhosis (PBC) is cholestatic liver disease characterized by progressive destruction of small bile ducts within the liver that can lead to end stage liver disease and all its complications. (clinicaltrials.gov)
  • The treatment of choledochal cyst is typically complete surgical excision at the time of presentation, with the exception of type V (multiple intrahepatic cysts) which may benefit from conservative therapy including percutaneous drainage and medical management. (medscape.com)
  • Histological examination revealed a moderately differentiated tubular adenocarcinoma without vascular or bile duct invasion, and with a preserved surgical margin (Fig. 3 ). (biomedcentral.com)
  • Surgical trauma causing damage to the bile ducts. (medindia.net)
  • Anatomy of the intrahepatic bile duct. (oncolink.org)
  • Anatomy of the extrahepatic bile duct. (oncolink.org)
  • Anatomy figure: 38:06-03 at Human Anatomy Online, SUNY Downstate Medical Center - "The gallbladder and extrahepatic bile ducts. (wikipedia.org)
  • Medical Student Finals Anatomy Gallbladder And The Bile Duct. (articles-publisher.com)
  • The Pancreas Anatomy Duct System Vasculature Teachmeanatomy. (articles-publisher.com)
  • These pathogens are through to induce malignancy through several means, including nitrosamine production, chronic inflammation and proliferation of the bile duct epithelium. (wikidot.com)
  • Bile can't travel though the blocked bile duct and it backs up, causing inflammation of the liver and pancreas. (medicinenet.com)
  • Inflammation leads to the narrowing of some portions of the bile ducts. (medindia.net)
  • Variations in the HLA complex can deregulate the immune system causing inflammation of the bile ducts. (medindia.net)
  • The isolated or simple form of Caroli disease is characterized by frequent recurring inflammation of the bile ducts inside the liver. (rarediseases.org)
  • KRAS mutation and immunohistochemical profile in intraductal papillary neoplasm of the intrahepatic bile ducts. (cdc.gov)
  • The hormone cholecystokinin , when stimulated by a fatty meal, promotes bile secretion by increased production of hepatic bile, contraction of the gall bladder, and relaxation of the Sphincter of Oddi . (wikipedia.org)
  • CCl 4 or mineral oil was given to bile duct-ligated (BDL) rats, and 1, 2, and 7 days later small and large cholangiocytes were purified and evaluated for apoptosis, proliferation, and secretion. (physiology.org)
  • CCl 4 induces selective apoptosis of large ducts associated with loss of large cholangiocyte proliferation and secretion. (physiology.org)
  • Cholangiocytes play an important role in the secretion of ductal bile under basal and hormone-regulated conditions ( 1-3 , 5-10 , 17 , 18 , 20 , 23 ). (physiology.org)
  • In the BDL rat model, cholangiocyte proliferation and increased ductal bile secretion occur in large cholangiocytes or large IBDU but are absent in small cholangiocytes or small IBDU ( 1 , 10 ). (physiology.org)