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Common Bile Duct NeoplasmsBile Duct NeoplasmsBile DuctsCommon Bile DuctBileBile Duct DiseasesBile Acids and SaltsBile Ducts, ExtrahepaticBile Ducts, IntrahepaticCommon Bile Duct DiseasesCholestasisPancreatic DuctsGallstonesAdenoma, Bile DuctCholangiopancreatography, Endoscopic RetrogradeHepatic Duct, CommonCholangiographyCholestasis, ExtrahepaticCystic DuctCholelithiasisThoracic DuctCholecystectomy, LaparoscopicJaundice, ObstructiveBiliary TractCholecystectomyBiliary Tract Surgical ProceduresCholangitisLigationCholedocholithiasisSphincterotomy, EndoscopicGallbladderPancreatic NeoplasmsBiliary Tract DiseasesSalivary DuctsLiverCholangiopancreatography, Magnetic ResonanceBile PigmentsAmpulla of VaterBile CanaliculiCholangiocarcinomaBiliary FistulaWolffian DuctsSphincter of OddiNeoplasmsCholestasis, IntrahepaticMullerian DuctsGallbladder NeoplasmsBile RefluxCholedochal CystLiver Cirrhosis, BiliaryBiliary AtresiaTaurocholic AcidNeoplasms, Cystic, Mucinous, and SerousCholedochostomyDrainagePancreatitisBiliary Tract NeoplasmsUrsodeoxycholic AcidBilirubinNeoplasms, Multiple PrimaryImmunohistochemistryCholangitis, SclerosingAdenocarcinoma, PapillaryCholic AcidsChenodeoxycholic AcidJejunostomyJaundiceLiver NeoplasmsKidney Tubules, CollectingCholagogues and CholereticsLiver DiseasesPancreaticoduodenectomyNasolacrimal DuctCystadenomaHepatectomySkin NeoplasmsCholecystitisLithiasisAnastomosis, Roux-en-YAdenocarcinoma, MucinousEjaculatory DuctsLithotripsyDilatation, PathologicRetrospective Studies1-NaphthylisothiocyanateCholic AcidDeoxycholic AcidEndoscopyIntraoperative ComplicationsIatrogenic DiseaseTomography, X-Ray ComputedSphincterotomy, TranshepaticAnastomosis, SurgicalLithocholic AcidTreatment OutcomePancreasKidney NeoplasmsPostoperative ComplicationsEndosonographyLiver Cirrhosis, ExperimentalDuodenal NeoplasmsCystsDuodenoscopyEndoscopesDuodenumCystadenoma, MucinousNeoplasms, Second PrimaryHepatic ArteryPancreatic DiseasesTaurodeoxycholic AcidTaurochenodeoxycholic AcidGallbladder DiseasesCystadenocarcinomaImino AcidsEnterohepatic CirculationConstriction, PathologicHepatocytesCatheterizationThyroid NeoplasmsEndoscopy, Digestive SystemAdenocarcinomaKlatskin's TumorLiver TransplantationPortal VeinCarcinoma, PapillaryCalculiMyeloproliferative DisordersDNA, NeoplasmLiver CirrhosisOrganic Anion Transporters, Sodium-DependentLiver Function TestsClonorchiasisLithotripsy, LaserCaroli DiseaseParotid NeoplasmsCarcinoma, Pancreatic DuctalVitelline DuctGlycocholic AcidKeratin-7Rats, Inbred F344Time FactorsEpitheliumLung NeoplasmsCholecystostomyLacrimal Duct ObstructionCholesterolCholecystographyNeoplasms, ExperimentalGastrointestinal NeoplasmsEndolymphatic DuctNeoplasms, Connective and Soft TissueRats, Sprague-DawleyNeoplasms, Plasma CellNeoplasm InvasivenessSalivary Gland NeoplasmsNeoplasms, Complex and MixedAppendiceal NeoplasmsTechnetium Tc 99m DisofeninNeoplasm StagingIntraoperative CareBiopsyOvarian NeoplasmsPancreatectomyEndocrine Gland NeoplasmsTumor Markers, BiologicalSphincter of Oddi DysfunctionDigestive System NeoplasmsCholecystitis, AcuteAdenomaDilatationDisease Models, AnimalFollow-Up StudiesCholesterol 7-alpha-HydroxylaseCarcinomaNeoplasm ProteinsDuodenal DiseasesNose NeoplasmsNeoplasms, Vascular TissueEpithelial CellsEye NeoplasmsPancreatitis, ChronicKeratinsDogsHamartomaDog DiseasesPortal SystemFatal OutcomeAntigens, NeoplasmNeoplasms, Radiation-InducedCystadenocarcinoma, MucinousCholecystolithiasisAdenoma, VillousFascioliasisTesticular NeoplasmsNeoplasms, Muscle TissueNeoplasms, Glandular and EpithelialSweat Gland NeoplasmsNervous System NeoplasmsIntestinal NeoplasmsSecretinLiver Neoplasms, Experimental
Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Bile Ducts: The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.Common Bile Duct: The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.Bile: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.Bile Duct Diseases: Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.Bile Acids and Salts: Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.Bile Ducts, Extrahepatic: Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).Bile Ducts, Intrahepatic: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.Common Bile Duct Diseases: Diseases of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Gallstones: Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.Adenoma, Bile Duct: A benign tumor of the intrahepatic bile ducts.Cholangiopancreatography, Endoscopic Retrograde: Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.Hepatic Duct, Common: Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.Cholangiography: An imaging test of the BILIARY TRACT in which a contrast dye (RADIOPAQUE MEDIA) is injected into the BILE DUCT and x-ray pictures are taken.Cholestasis, Extrahepatic: Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.Cystic Duct: The duct that is connected to the GALLBLADDER and allows the emptying of bile into the COMMON BILE DUCT.Cholelithiasis: Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).Thoracic Duct: The largest lymphatic vessel that passes through the chest and drains into the SUBCLAVIAN VEIN.Cholecystectomy, Laparoscopic: Excision of the gallbladder through an abdominal incision using a laparoscope.Jaundice, Obstructive: Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.Biliary Tract: The BILE DUCTS and the GALLBLADDER.Cholecystectomy: Surgical removal of the GALLBLADDER.Biliary Tract Surgical Procedures: Any surgical procedure performed on the biliary tract.Cholangitis: Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.Ligation: Application of a ligature to tie a vessel or strangulate a part.Choledocholithiasis: Presence or formation of GALLSTONES in the COMMON BILE DUCT.Sphincterotomy, Endoscopic: Incision of Oddi's sphincter or Vater's ampulla performed by inserting a sphincterotome through an endoscope (DUODENOSCOPE) often following retrograde cholangiography (CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE). Endoscopic treatment by sphincterotomy is the preferred method of treatment for patients with retained or recurrent bile duct stones post-cholecystectomy, and for poor-surgical-risk patients that have the gallbladder still present.Gallbladder: A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Biliary Tract Diseases: Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Salivary Ducts: Any of the ducts which transport saliva. Salivary ducts include the parotid duct, the major and minor sublingual ducts, and the submandibular duct.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Cholangiopancreatography, Magnetic Resonance: Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.Bile Pigments: Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Bile Canaliculi: Minute intercellular channels that occur between liver cells and carry bile towards interlobar bile ducts. Also called bile capillaries.Cholangiocarcinoma: A malignant tumor arising from the epithelium of the BILE DUCTS.Biliary Fistula: Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.Wolffian Ducts: A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. In higher vertebrates, Wolffian ducts persist in the male forming VAS DEFERENS, but atrophy into vestigial structures in the female.Sphincter of Oddi: The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).Mullerian Ducts: A pair of ducts near the WOLFFIAN DUCTS in a developing embryo. In the male embryo, they degenerate with the appearance of testicular ANTI-MULLERIAN HORMONE. In the absence of anti-mullerian hormone, mullerian ducts give rise to the female reproductive tract, including the OVIDUCTS; UTERUS; CERVIX; and VAGINA.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Bile Reflux: Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.Choledochal Cyst: A congenital anatomic malformation of a bile duct, including cystic dilatation of the extrahepatic bile duct or the large intrahepatic bile duct. Classification is based on the site and type of dilatation. Type I is most common.Liver Cirrhosis, Biliary: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.Biliary Atresia: Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.Neoplasms, Cystic, Mucinous, and Serous: Neoplasms containing cyst-like formations or producing mucin or serum.Choledochostomy: Surgical formation of an opening (stoma) into the COMMON BILE DUCT for drainage or for direct communication with a site in the small intestine, primarily the DUODENUM or JEJUNUM.Drainage: The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.Biliary Tract Neoplasms: Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Ursodeoxycholic Acid: An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.Bilirubin: A bile pigment that is a degradation product of HEME.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Cholic Acids: The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.Jejunostomy: Surgical formation of an opening through the ABDOMINAL WALL into the JEJUNUM, usually for enteral hyperalimentation.Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.Liver Neoplasms: Tumors or cancer of the LIVER.Kidney Tubules, Collecting: Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.Cholagogues and Choleretics: Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).Liver Diseases: Pathological processes of the LIVER.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.Nasolacrimal Duct: A tubular duct that conveys TEARS from the LACRIMAL GLAND to the nose.Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Skin Neoplasms: Tumors or cancer of the SKIN.Cholecystitis: Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.Lithiasis: A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.Anastomosis, Roux-en-Y: A Y-shaped surgical anastomosis of any part of the digestive system which includes the small intestine as the eventual drainage site.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Ejaculatory Ducts: Paired ducts in the human male through which semen is ejaculated into the urethra.Lithotripsy: The destruction of a calculus of the kidney, ureter, bladder, or gallbladder by physical forces, including crushing with a lithotriptor through a catheter. Focused percutaneous ultrasound and focused hydraulic shock waves may be used without surgery. Lithotripsy does not include the dissolving of stones by acids or litholysis. Lithotripsy by laser is LITHOTRIPSY, LASER.Dilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.1-Naphthylisothiocyanate: A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.Cholic Acid: A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.Deoxycholic Acid: A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.Endoscopy: Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.Intraoperative Complications: Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.Iatrogenic Disease: Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Sphincterotomy, Transhepatic: Surgery of the smooth muscle sphincter of the hepatopancreatic ampulla to relieve blocked biliary or pancreatic ducts.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Endosonography: Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.Liver Cirrhosis, Experimental: Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Duodenoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.Endoscopes: Instruments for the visual examination of interior structures of the body. There are rigid endoscopes and flexible fiberoptic endoscopes for various types of viewing in ENDOSCOPY.Duodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Hepatic Artery: A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.Pancreatic Diseases: Pathological processes of the PANCREAS.Taurodeoxycholic Acid: A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.Taurochenodeoxycholic Acid: A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.Gallbladder Diseases: Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Imino AcidsEnterohepatic Circulation: Recycling through liver by excretion in bile, reabsorption from intestines (INTESTINAL REABSORPTION) into portal circulation, passage back into liver, and re-excretion in bile.Constriction, Pathologic: The condition of an anatomical structure's being constricted beyond normal dimensions.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Endoscopy, Digestive System: Endoscopic examination, therapy or surgery of the digestive tract.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Klatskin's Tumor: Adenocarcinoma of the common hepatic duct bifurcation. These tumors are generally small, sharply localized, and seldom metastasizing. G. Klatskin's original review of 13 cases was published in 1965. Once thought to be relatively uncommon, tumors of the bifurcation of the bile duct now appear to comprise more than one-half of all bile duct cancers. (From Holland et al., Cancer Medicine, 3d ed, p1457)Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Calculi: An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.DNA, Neoplasm: DNA present in neoplastic tissue.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Organic Anion Transporters, Sodium-Dependent: A subclass of ORGANIC ANION TRANSPORTERS whose transport of organic anions is driven either directly or indirectly by a gradient of sodium ions.Liver Function Tests: Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.Clonorchiasis: Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)Lithotripsy, Laser: Fragmentation of CALCULI, notably urinary or biliary, by LASER.Caroli Disease: Congenital cystic dilatation of the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). It consists of 2 types: simple Caroli disease is characterized by bile duct dilatation (ectasia) alone; and complex Caroli disease is characterized by bile duct dilatation with extensive hepatic fibrosis and portal hypertension (HYPERTENSION, PORTAL). Benign renal tubular ectasia is associated with both types of Caroli disease.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Vitelline Duct: The narrow tube connecting the YOLK SAC with the midgut of the EMBRYO; persistence of all or part of it in post-fetal life produces abnormalities, of which the commonest is MECKEL DIVERTICULUM.Glycocholic Acid: The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Rats, Inbred F344Time Factors: Elements of limited time intervals, contributing to particular results or situations.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Lung Neoplasms: Tumors or cancer of the LUNG.Cholecystostomy: Establishment of an opening into the gallbladder either for drainage or surgical communication with another part of the digestive tract, usually the duodenum or jejunum.Lacrimal Duct Obstruction: Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Cholecystography: Radiography of the gallbladder after ingestion of a contrast medium.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Endolymphatic Duct: The part of the membranous labyrinth that traverses the bony vestibular aqueduct and emerges through the bone of posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) where it expands into a blind pouch called the endolymphatic sac.Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Neoplasms, Complex and Mixed: Neoplasms composed of more than one type of neoplastic tissue.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Technetium Tc 99m Disofenin: A radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4)Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Intraoperative Care: Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Pancreatectomy: Surgical removal of the pancreas. (Dorland, 28th ed)Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Sphincter of Oddi Dysfunction: Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Cholecystitis, Acute: Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.Adenoma: A benign epithelial tumor with a glandular organization.Dilatation: The act of dilating.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Cholesterol 7-alpha-Hydroxylase: A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Duodenal Diseases: Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).Nose Neoplasms: Tumors or cancer of the NOSE.Neoplasms, Vascular Tissue: Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Eye Neoplasms: Tumors or cancer of the EYE.Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Hamartoma: A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Portal System: A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Cholecystolithiasis: Presence or formation of GALLSTONES in the GALLBLADDER.Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Fascioliasis: Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Neoplasms, Muscle Tissue: Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Sweat Gland NeoplasmsNervous System Neoplasms: Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Secretin: A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.

Lobar decrease in 99mTc-GSA accumulation in hilar cholangiocarcinoma. (1/1182)

Hilar cholangiocarcinoma can obstruct hepatic ducts and involve the portal veins. Both biliary stasis and decrease in portal venous flow are known to reduce 99mTc-diethylenetriamine pentaacetic acid-galactosyl human serum albumin (GSA) accumulation. The specific relationship between these pathological conditions due to hilar cholangiocarcinomas and 99mTc-GSA accumulation has never been clarified. METHODS: Sixteen patients with hilar cholangiocarcinomas who underwent 99mTc-GSA liver scintigraphy were reviewed. The relationship between significant decrease in 99mTc-GSA accumulation and lobar biliary stasis, or decrease in the portal venous flow, was evaluated. Average counts of region of interest placed in both right and left lobes were compared in the same transaxial SPECT section. Count ratios of right and left lobes were calculated. RESULTS: Significant lobar decrease in 99mTc-GSA accumulation was observed in 6 of the 16 patients. Ipsilateral portal venous stenosis or obstruction was seen in all these 6 patients, whereas ipsilateral portal venous stenosis or obstruction was seen in only 1 of the other 10 patients. Symmetric bile duct dilatation was seen in 13 patients, and asymmetric bile duct dilatation was seen in 3. Lobar decrease in 99mTc-GSA accumulation correlated well with decrease in ipsilateral portal venous flow (P < 0.0005). The count ratio was significantly reduced when unilateral portal venous flow decreased (P < 0.05). CONCLUSION: Using 99mTc-GSA liver scintigraphy, we can predict lobar decrease in ipsilateral portal venous flow and monitor hepatic functional lateralities in patients with hilar cholangiocarcinomas.  (+info)

Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis. (2/1182)

Extrahepatic biliary stenosis can be caused by benign and malignant disorders. In most cases, a tissue diagnosis is needed for optimal management of patients, but the sensitivity of biliary cytology for the diagnosis of a malignancy is relatively low. The additional diagnostic value of K-ras mutational analysis of endobiliary brush cytology was assessed. Endobiliary brush cytology specimens obtained during endoscopic retrograde cholangiopancreaticography were prospectively collected from 312 consecutive patients with extrahepatic biliary stenosis. The results of conventional light microscopic cytology and K-ras codon 12 mutational analysis were compared and evaluated in view of the final diagnosis made by histological examination of the stenotic lesion and/or patient follow-up. The sensitivities of cytology and mutational analysis to detect malignancy were 36 and 42%, respectively. When both tests were combined, the sensitivity increased to 62%. The specificity of cytology was 98%, and the specificity of the mutational analysis and of both tests combined was 89%. Positive predictive values for cytology, mutational analysis, and both tests combined were 98, 92, and 94%, whereas the corresponding negative predictive values were 34, 34, and 44%, respectively. The sensitivity of K-ras mutational analysis was 63% for pancreatic carcinomas compared to 27% for bile duct, gallbladder, and ampullary carcinomas. K-ras mutational analysis can be considered supplementary to conventional light microscopy of endobiliary brush cytology to diagnose patients with malignant extrahepatic biliary stenosis, particularly in the case of pancreatic cancer. The presence of a K-ras codon 12 mutation in endobiliary brush cytology per se supports a clinical suspicion of malignancy, even when the conventional cytology is negative or equivocal.  (+info)

Villous adenoma of the bile ducts: a case report and a review of the reported cases in Korea. (3/1182)

Villous adenomas are benign epithelial lesions with malignant potential which can occur at any site in the gastrointestinal tract. They are usually encountered in the rectum and colon, less frequently in the small bowel and very rarely in the biliary trees. Nine cases of bile duct villous adenomas have been reported in the literature. However, 4 cases of bile duct villous adenomas have been reported in the Korean literature. Recently, we experienced a case of villous adenoma in the common hepatic duct in a 77-year-old man presenting with obstructive jaundice in which preoperative histologic diagnosis of villous adenoma played a critical role in managing this patient. Herein, we present a case report of bile duct villous adenoma and a review of the reported cases in Korea to help define and manage this rare disease entity in the bile ducts. In addition, confusing nomenclature of bile duct adenomas is discussed.  (+info)

Lymph node metastasis in intrahepatic cholangiocarcinoma. (4/1182)

BACKGROUND: Lymph node metastasis is a significant prognostic factor in intrahepatic cholangiocarcinoma. This study was aimed at investigating lymph node metastasis in intrahepatic cholangiocarcinoma and to examine whether the extent of metastasis affects outcomes after surgery. METHODS: From 1980 through 1996, 70 patients with intrahepatic cholangiocarcinoma underwent hepatectomy, with a 50% curative resection rate. Lymph node dissection was performed in 51 patients, and the presence of lymph node metastasis was examined microscopically. The metastatic nodes were divided into groups N1, N2 or N3 using the classification proposed by the Liver Cancer Study Group of Japan. RESULTS: Twenty-three patients had lymph node metastasis. Metastasis was to N1 nodes in 10 patients, to N2 nodes in nine patients and to N3 nodes in four patients. Nineteen patients had metastatic nodes in the hepatoduodenal ligament, which was the most common metastatic site regardless of tumor location. The five-year survival rate in patients with lymph node metastasis (0%) was significantly lower (p < 0.0001) than that in patients without lymph node metastasis (51 %); however, five-year survival rates did not differ between patients with metastases to N1, N2 and N3 nodes. CONCLUSIONS: Lymph nodes in the hepatoduodenal ligament may be sentinel nodes for intrahepatic cholangiocarcinoma, and outcomes after surgery for patients with lymph node metastasis are poor regardless of the sites of nodal metastasis.  (+info)

Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. (5/1182)

The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats.  (+info)

Problems and perspective in epidemiological study of occupational health hazards in the rubber industry. (6/1182)

An epidemiological analysis of the problems in the study of companies engaged in the manufacture of rubber products in different countries and in different time periods is given. Selected findings on cancer of gallbladder and biliary system, cancer of the lung, and tumors of the central nervous system among rubber workers are presented.  (+info)

Detection of Helicobacter DNA in bile from bile duct diseases. (7/1182)

Several species of Helicobacter colonize the hepatobiliary tract of animals and cause hepatobiliary diseases. The aim of this study is to investigate Helicobacter found in the biliary tract diseases of humans. Thirty-two bile samples (15 from bile duct cancer, 6 from pancreatic head cancer, and 11 from intrahepatic duct stone) were obtained by percutaneous transhepatic biliary drainage. Polymerase chain reaction analysis using Helicobacter specific urease A gene and 16S rRNA primers, bile pH measurement, and Helicobacter culture were performed. Helicobacter DNA was detected in 37.5%, and 31.3% by PCR with ureA gene, and 16S rRNA, respectively. The bile pH was not related to the presence of Helicobacter. The cultures were not successful. In conclusion, Helicobacter can be detected in the bile of patients with bile duct diseases. The possibility of pathogenesis of biliary tract diseases in humans by these organisms will be further investigated.  (+info)

Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver. (8/1182)

p73, the first homologue of the tumour suppressor protein p53, was recently discovered on chromosome 1p36 and has been shown to induce apoptosis in a p53-like manner. The present study was performed with the aim of investigating the expression of p53, its new homologue p73 and the occurrence of apoptosis in cholangiocellular carcinoma. Protein levels of p73 were examined in 41 patients with curatively (R0-) resected cholangiocellular carcinomas with an antiserum, raised against a peptide in the N-terminal domain of p73. The incidence of mutations in the p53 gene was analysed by direct sequencing and also immunohistochemically. Apoptotic cell death was assessed using in-situ end-labelling (ISEL) technique in combination with morphological criteria. The results obtained were correlated with patient survival. Immunostaining of p73 protein was detected in 17/41 carcinomas examined (41%). The immunoreactivity was confined to the cell nucleus. In 15/41 patients (37%), mutations of the p53 gene were observed. Eleven out of these 15 patients stained also positive for p73. In contrast, out of 26 patients without any detectable p53 mutation, only six exhibited p73 immunostaining. We failed to observe a correlation between p73 expression or p53 and apoptosis within a given tumour. Survival analysis including the parameters stage and grade of disease, p73 and p53, and also apoptosis, showed that tumour stage and grade as well as p53 and p73 were significantly related to prognosis. In Cox regression survival analysis, however, only extent of primary tumour and lymph node status had an independent prognostic impact. Our results with a high prevalence of p73 within tumours harbouring mutated p53 gene suggest that p73 could compensate for p53 function. We failed to establish p73 or p53 as independent prognostic factors in cholangiocellular carcinoma of the liver.  (+info)

Immunohistochemical study of p53 mutation and p16, p14 alterations encoded by INK4a-ARF in mucin-hypersecreting bile duct tumor...Immunohistochemical study of p53 mutation and p16, p14 alterations encoded by INK4a-ARF in mucin-hypersecreting bile duct tumor...
BACKGROUND/AIMS Mucin-hypersecreting bile duct tumor is rare, and has an unusual histologic characteristic of having various degrees of cellular atypia ranging from dysplasia to invasive carcinoma in the same specimen. To gain insight into the role of p16, p14 and p53 in the carcinogenic process of bile duct tumor, we analyzed the expression status of these proteins in mucin-hypersecreting bile duct tumor. METHODS Immunohistochemical staining of p16, p14 and p53 were performed in 34 paraffin embedded tissues obtained from 22 patients of mucin-hypersecreting bile duct tumor. RESULTS Thirty-four specimens were categorized into low-grade dysplasia (9), high-grade dysplasia (4), carcinoma in situ (CIS, 11) and invasive carcinoma (10) based on the degree of cytologic and structural atypia. p53 overexpressions were found in 6 (17.6%, 3 in CIS, 3 in invasive carcinoma) and more frequently observed in the advanced histologic stages (p|0.05). Loss of p16 staining was found only in 2 (6%) of low-grade
GW Researchers Discover Biomarker for Advanced Bile Duct Fibrosis and Bile Duct CancerGW Researchers Discover Biomarker for Advanced Bile Duct Fibrosis and Bile Duct Cancer
Northeastern Thailand has the highest levels bile duct cancer in the world. The determination that plasma IL-6 levels are associated with bile duct fibrosis (a precursor state to bile duct cancer) and early bile duct cancer were done by examining participants in the Khon Kaen Cholangiocarcinoma Cohort, the largest cancer cohort of its type in the world, and an NIH sponsored project in collaboration with George Washington University and Khon Kaen University. In this study, researchers visited nearly 4,000 individuals resident in rural areas of Thailand, where the parasite is endemic to conduct ultrasound studies to detect advanced bile duct fibrosis and early bile duct cancer and then link the ultrasound results with levels of plasma IL-6. This research was done in collaboration with Drs. Banchob Sripa, Bandit Thinkhamrop, Eimorn Mairiang, and Thewarach Laha from the Khon Kaen University School of Medicine and School of Public Health. ...
Bile Duct Cancer | Causes and Symptom Of Bile Duct Cancer | RadiotherapyBile Duct Cancer | Causes and Symptom Of Bile Duct Cancer | Radiotherapy
Bile duct cancer information with its causes along with various treatments available. A parasitic infection called the liver fluke is known to be responsible for causing the bile duct cancer. Detailed description of bile duct cancer symptoms also given.
Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®): Treatment - Health Professional Information [NCI] | PeaceHealthBile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®): Treatment - Health Professional Information [NCI] | PeaceHealth
Cancer of the bile duct (also called cholangiocarcinoma) is extremely rare. The true incidence of bile duct cancer is unknown, however, because establishing an accurate diagnosis is difficult. Traditionally, bile duct tumors located within the liver have been classified with hepatocellular carcinoma as primary liver...
Best Bile Duct Cancer Doctor in Bangalore, Bile Duct Cancer Doctors | CredihealthBest Bile Duct Cancer Doctor in Bangalore, Bile Duct Cancer Doctors | Credihealth
Find the best bile duct cancer doctors in Bangalore. Get guidance from medical experts to select bile duct cancer specialist in Bangalore from trusted hospitals - credihealth.com
Utility of CholangioFlex and Fluorescent in Situ Hybridization in the Diagnosis of Malignant Biliary Strictures - Full Text...Utility of CholangioFlex and Fluorescent in Situ Hybridization in the Diagnosis of Malignant Biliary Strictures - Full Text...
Confocal endomicroscopy (CholangioFlex) was performed at the suspected area. The video will record the images with Cellvizio program recorder.. 6.Brush cytology was performed 7.Record the duration and complication of the procedure 8.Send the tissues to one clinically-blinded GI pathologist for pathological diagnosis and FISH test 9.Compare the pathology and FISH report and endoscopic finding 10.Report the result According to Miami-criteria 2009, the Criteria for malignant biliary stricture from CholangioFlex are one of the followings;. ...
Bile Duct Cancer PrognosisBile Duct Cancer Prognosis
Cholangiocarcinoma (bile duct cancer) usually develops in the bile duct system that arises from the liver and bile ducts and ends at the small intestine. Cancer that develops in the section of bile ducts within and outside the liver is called as intrahepatic and hilar cholangiocarcinoma, respectively. Distal cholangiocarcinoma is developed in the bile section that is associated with small intestine. Prognostic factors of cholangiocarcinoma are highly disputable.
Prognostic value of p53 and Ki-67 expression in resected or biopsy specimens of bile duct carcinomaPrognostic value of p53 and Ki-67 expression in resected or biopsy specimens of bile duct carcinoma
For cases of inoperable bile duct carcinoma, we perform intraluminal irradiation using an 192iridium wire following endoprostheses implantation. However, the effectiveness of this procedure is uncertain, and may lead to decreased patient quality of life in some cases. Therefore, we obtained samples of bile duct carcinoma either by percutaneous transhepatic cholangioscope (PTCS) or by surgery, and studied whether expression levels of Ki-67 and p53 in these tissues could predict the effectiveness of radiotherapy (RT). Immunohistochemistry was used to determine the expression of p53 and Ki-67 in 40 resected and 18 biopsy specimens. All biopsy specimens were stage IVA according to UICC classification. Labeling indices were calculated as percentage of positively stained tumor cell nuclei of total tumor cells counted. Samples were divided into two groups according to labeling index (LI). In the resected specimens, Ki-67 LI was significantly higher in cases positive for lymphatic invasion than in ...
Bile Duct Cancer Causes,View All Pages | CancerNet,What is bile duct cancer|2020-06-25-H&R Block 2019 Best Price CouponsBile Duct Cancer Causes,View All Pages | CancerNet,What is bile duct cancer|2020-06-25-H&R Block 2019 Best Price Coupons
Final Symptoms Of Liver Cancer , Healthfully. Choose whole-grain breads, pastas, and cereals instead of refined grains.The exocrine group is dominated by pancreatic adenocarcinoma (variations of this name may add invasive and ductal), which is by far the most common type, representing about 85% of all pancreatic cancers.Surgery may be needed in some situations.10 Conditions Treatable with Medical Marijuana.It can also make a persons urine a dark color and make bowel movements pale.Your doctor usually puts in a tube (stent) to open up the blockage, which helps to relieve symptoms.HIPEC can be more effective than other medicines to treat cancer in the abdomen.Optimized by Phoenix Arizona SEO CompanyOptimizex.It would be removed in hours. A tumor in the bile duct can block the flow of bile into the intestine and the bile that is accumulated in the ducts causes the skin to turn yellow.. Controlling Symptoms Of Advanced Cancer , Bile Duct Cancer .... Use the menu to see other pages.Sep 01, 2012A ...
What is bile duct cancer? - Canadian Cancer SocietyWhat is bile duct cancer? - Canadian Cancer Society
Bile duct cancer starts in the cells of a bile duct. Learn about symptoms, diagnosis, treatment and risks in our guide to bile duct cancer.
With Linear 125I Seeds Implantation Combined with Biliary Stent Insertion, we resolve the obstruction of bile duct cancer |...With Linear 125I Seeds Implantation Combined with Biliary Stent Insertion, we resolve the obstruction of bile duct cancer |...
Linear 125 I Seeds Implantation Combined with Biliary Stent Insertion is an emerging effective treatment for bile duct cancer patients with obstructive jaundice, which can simultaneously treat biliary obstruction and bile duct tumors, bringing new hop
Gemcitabine With Peptide Vaccine Therapy in Treating Patients With Bile Duct Cancer - Full Text View - ClinicalTrials.govGemcitabine With Peptide Vaccine Therapy in Treating Patients With Bile Duct Cancer - Full Text View - ClinicalTrials.gov
Our previous studies have demonstrated that up-regulated lung cancer 10 (URLC10) has been identified as a new target of tumor associated antigen using cDNA microarray technique combined with the expression profiles of normal and cancer tissues. We have also found that 100% of tissue samples from bile duct cancer express URLC10. We have determined the HLA-A*2402 and HLA-A*0201 restricted epitope peptides derived from URLC10.These epitope peptides have shown to induce specific Cytotoxic T Lymphocytes (CTL). Furthermore, 60% and 20% of Japanese population have HLA-A*2402 and HLA-A*0201, respectively. Therefore, these peptides are suitable for clinical trial. On the other hand, gemcitabine is a drug approved against bile duct cancer. Recent studies has reported that gemcitabine has an additional ability to improve immune response. From these results, synergistic effect between vaccine therapy and chemotherapy using gemcitabine will be expected.. In this clinical trial, we evaluate the safety, ...
Bile Duct Cancer TreatmentBile Duct Cancer Treatment
There are several bile duct cancer treatment and preventive procedures to administer to patients of bile duct cancer. Treatments would vary depending on th
Bile Duct Cancer in Dogs - Dog HouseBile Duct Cancer in Dogs - Dog House
Cholangiocellular Carcinoma in Dogs Bile duct carcinoma is a malignant cancer that typically arises from the the epithelia, the cellular lining of the hepatic (
Bile Duct Cancer (Cholangiocarcinoma)Bile Duct Cancer (Cholangiocarcinoma)
Bile duct cancer symptoms include jaundice and abdominal pain. Turn to the expert gastroenterologists at Johns Hopkins for accurate diagnosis and personalized treatment.
Bile Duct Cancer | Cholangiocarcinoma - GlossaryBile Duct Cancer | Cholangiocarcinoma - Glossary
Looking for simple explanations to difficult medical terms that tend to puzzle you? This glossary can help you to easily understand medical terms related to the article on Bile Duct Cancer
Bile Duct Cancer: SymptomsBile Duct Cancer: Symptoms
Jaundice. This is the yellowing of the whites of the eyes and skin. Its caused by a buildup of bilirubin in the blood. Bilirubin is a yellow-brown substance in bile. The liver makes bile. Bile travels from the liver through the bile ducts the intestine. Bile digests or breaks down fats from food in the intestine. If the bile ducts are blocked by a tumor or scarring, bile backs up. Jaundice is the most common symptom of bile duct cancer outside the liver (extrahepatic).. ...
Bile Duct Cancer | Cacner Care in Orange CountyBile Duct Cancer | Cacner Care in Orange County
Bile duct cancer describes a type of cancer that forms in the bile ducts (slender tubes) that carry the digestive fluid bile through the liver. Get treatment now!
Bile Duct Cancer - Cancer NorthBile Duct Cancer - Cancer North
Surgery: If tumors are small and caught early, your doctor may be able to eliminate all of the cancer cells by removing part of the bile duct. If the cancer has advanced, your doctor may need to remove some liver tissue, as well. Bile duct cancer surgery may be performed in conjunction with radiation therapy, chemotherapy, or both ...
https://www.cancer.gov/types/liver/hp/bile-duct-treatment-pdqhttps://www.cancer.gov/types/liver/hp/bile-duct-treatment-pdq
Bile duct cancer (also called cholangiocarcinoma) can occur in the bile ducts in the liver (intrahepatic) or outside the liver (perihilar or distal extrahepatic). Learn about the types of bile duct cancer, risk factors, clinical features, staging, and treatment for bile duct cancer in this expert-reviewed summary.
Treating Bile Duct CancerTreating Bile Duct Cancer
Regular physical challenges remain, causing pain, queasy stomach treating bile duct cancer after gallbladder infections of the gallbladder. These remedies, you could be because I felt nauseous and pain in gallbladder not confirm gallstones. PMID 11930198 Myers RP, Shaffer EA, Beck PL 2002. Just beneath your spot on the liver qi deficiency liver or bile pigment crystals and become too large numbers. Shiftig of worn-out red blood pancreatic cancer prognosis kidney disease cells, into the doc about it, but eating certain herbs that work on your health, many experts highly recommend this. These hardened deposits that results in problems after gallbladder removal gallstones the gallbladder is an extensive buildup of scar tissue pancreatic cancer prognosis kidney disease from older surgery recovery. Other symptoms include fever, drainage from $6, 000. The adoption of the gallbladder in order to prevent gallstones naturally and financially saturated fats. Once the pellets continue cirrhosis of ...
Metastasis Of Bile Duct CancerMetastasis Of Bile Duct Cancer
liver disease facts mexico Kid clear capsule is there is a risk of gallbladder removal was done in order to cure and delivers excellent results. Gallstones can be caused by some natural health problems once they become large and clinical interventions in the gallbladder pain and risks that should be taken. Therefore, it is an important internal organ illnesses. As a result of which uses more cholesterol is impossible. Try these foods: eggs, dairy, are still over a 20-year period. These are usually suggested according to the hospital for two more weeks, I have done long ago. It is most metastasis of treatment for fatty liver disease in alcoholics bile duct cancer likely to suffer from these as compared to men. To follow the guidelines for instance instead of tasty and three-dimensional visualization, enhanced dexterity, greater precision, enhanced maneuverability and try to dissolve and pass your gallbladder. The bile in the abdomen that showed raised antibodies to gluten/gliadin, among other ...
OHSU researchers: Surgery, radiation gives early survival advantage in bile duct cancer | EurekAlert! Science NewsOHSU researchers: Surgery, radiation gives early survival advantage in bile duct cancer | EurekAlert! Science News
Oregon Health & Science University researchers are reporting the discovery of an early survival advantage when a combination of surgery and radiation therapy is used for patients with a rare but deadly bile duct cancer.
Rare Cancer News & Clinical Trials » Trial - Bile Duct Cancer » A Pilot Study to Assess Theragnostically Planned Liver...Rare Cancer News & Clinical Trials » Trial - Bile Duct Cancer » A Pilot Study to Assess Theragnostically Planned Liver...
Rare Cancer News & Clinical Trials » Trial - Bile Duct Cancer » A Pilot Study to Assess Theragnostically Planned Liver Radiation With Functional DVH Analysis to Optimize Individualized Radiation ...
Chemotherapy for Bile Duct CancerChemotherapy for Bile Duct Cancer
Chemotherapy (chemo) is a treatment of cancer-killing drugs used to kill bile duct cancer cells. Learn more about chemotherapy here.
Bile Duct Cancer | Cancer Survivors NetworkBile Duct Cancer | Cancer Survivors Network
Hi,. My mom was just diagnosed with Bile Duct Cancer.. I am in departed need of anyone who has dealt with this type of cancer, or any ones family members who had this. I also would love to hear from people who has beat this type of cancer... this has been a world-wind we never ever expected this to happen; especially in November we was told NO-Cancer!! My mom is my life; we are best friends she lives not even a mile from me. I am so hurt, mad & even angry. I have never ever felt so alone in my LIFE... I will be by my mothers side every-step of the way... I want any suggestions on how to cope with all feelings I am felling. Please help!!!! ...
Bile Duct Cancer Treatment<...Bile Duct Cancer Treatment<...
besides traditional surgery, chemotherapy and radiotherapy for bile duct cancer treatment, there are still integrated combination of TCM and western medicines as well as interventional therapy.
Bile duct cancer diagnosis: Costs for treatment #33463 in Germany | BookingHealthBile duct cancer diagnosis: Costs for treatment #33463 in Germany | BookingHealth
Bile duct cancer diagnosis (costs for program #33463) ✔ Sana Hospital Duisburg ✔ Department of Internal Medicine II (Gastroenterology and Hepatology) ✔ BookingHealth.com
Lifestyle Changes After Treatment for Bile Duct CancerLifestyle Changes After Treatment for Bile Duct Cancer
You cant change the fact that you had bile duct cancer, but you can change how you live the rest of your life by making healthy lifestyle choices.
Bile Duct Cancer in Dogs | petMDBile Duct Cancer in Dogs | petMD
Bile duct carcinoma is a malignant cancer that typically arises from the the epithelia, the cellular lining of the hepatic (liver) bile ducts.
Glossary of Terms | PSC CommunityGlossary of Terms | PSC Community
A. AIH - Autoimmune Hepatitis. ALP - Alkaline Phosphatase (ALP). ALT - Alanine Aminotransferase (sometimes called SGPT). AST - Aspartate Aminotransferase (sometimes called SGOT). Asymptomatic - displaying no symptoms. B. Bacterial cholangitis - infection in the bile ducts. Bile ducts - the passages that carry bile from the liver to the intestines. BMD - bone mass density. C. CCA - cholangiocarcinoma (bile duct cancer). CD - Crohns Disease. Cholangiocarcinoma - bile duct cancer. Choledocholithiasis - biliary stones. Colonoscopy - test to examine the colon and rectum. D. DEXA - bone density scan. E. ERCP - Endoscopic retrograde cholangiopancreatogram. Extrahepatic - outside the liver. F. Fatigue - debilitating tiredness. G. GGT - Gamma-Glutamyl Transferase. H. HCC - hepatocellular carcinoma. HE - hepatic encephalopathy. I. IAC - Immunoglobulin G4 (IgG4) Associated Cholangitis. IBD - Inflammatory Bowel Disease. IgG4 - Immunoglobulin G4. Intrahepatic - within the liver. L. LFT - Liver function ...
The diagnostic and prognostic value of genetic aberrations in resectable distal bile duct cancerThe diagnostic and prognostic value of genetic aberrations in resectable distal bile duct cancer
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. ...
Vesalius Clinical Folios: Whipple Procedure for Bile Duct CarcinomaVesalius Clinical Folios: Whipple Procedure for Bile Duct Carcinoma
The superior mesenteric, splenic and portal vein are shown in relation to the pancreas and superior mesenteric artery. The first branches arising from the anterior surfaces of SMA and SMV are the middle colic vessels. Note the small venous branches from the head draining into the right side of the SMV/portal veins, and the multiple small branches from the body of the pancreas draining into the anterior surface of the splenic vein ...
Bile Duct Cancer and Potential Risk Factor-Bacteria | DrStegall.comBile Duct Cancer and Potential Risk Factor-Bacteria | DrStegall.com
Dr. Stegalls Comments: There are many theories as to how cancer develops, and one of them is that cancer starts as a bacteria. The idea that bacteria could cause cholangiocarcinoma is an interesting one, as it would suggest a possible target for treatment using off-label antibiotic regimens. I typically include a low dose antibiotic given intravenously in periodic fashion as part of my treatment protocols, in case there is a bacterial component ...
And LemonsAnd Lemons
belly buttons using the beet. She was the formation is the best remedies for gallbladder. Bile is a common place surgery every surgery and only you can do for you as it used to reduce inflammation of the gallbladder removal, indigestion symptoms with back pain the authors concluded that is attached to the military may emerge. This caused by feelings and feeling pretty lousy! The gallbladder detox diet containing fats, the gallstones have been taught at medical schools. Recommended procedure of removing bile duct cancer survival rate natural remedies for gallstones removal gallstones without the next 10 years after the procedure each year more than 10 cm sac that is because if you have a high fat and lean cuts. Thats why bile duct cancer survival rate mates and loved ones, along with increasing. It is when the organ is extremely popular for people with cancer. One should also be experiencing are similar to a variety of procedure each year more than 15-20 years, you should have felt sick after ...
Bile duct cancer | Cancer Survivors NetworkBile duct cancer | Cancer Survivors Network
Tina, dont give up even if you think the doctors giving up. My CT scan came back six weeks ago after my treatments, not looking good. I went to the gastroentrologist that had put in the stent and he did not want to answer any of my questions. He answered them by telling me to ask the oncologist. I asked about making another follow-up appointment and he said he didnt think that would be necessary. What a blow that was! I went to the oncologist and after I got a copy of the report, I could see that it did not look good, I called and wanted to ask some questions and he said we would talk about it in a month after I have another CT scan. Another blow! I was not going to sit around, so I made an appointment with another oncologist and she went over my CT scan and explained that it did not look that bad. The new spot on the liver could be a cyst and the fluid around the gallbladder did not mean it was cancer and the fluid would probably go away. I did have another CT scan just before Christmas and ...
Stow-on-the-Wold Surgery - Library - Health A-ZStow-on-the-Wold Surgery - Library - Health A-Z
In bile duct cancer, the cancerous cells may release certain chemicals that can be detected using blood tests. These are known as tumour markers.. But tumour markers can also be caused by other conditions, so this test cant be used to say for certain whether or not you have bile duct cancer.. ...
Bile Duct Cancer: ChemotherapyBile Duct Cancer: Chemotherapy
Its important to know which medicines youre taking. Write your medicines down, ask your healthcare team how they work, and what side effects they might have.. Talk with your healthcare providers about what signs to look for, and when to call them. Be sure you know how to get help any time, including after office hours and on weekends.. It may be helpful to keep a diary of your side effects. Write down physical and emotional changes. A written list will make it easier for you to remember your questions when you go to your appointments. It will also make it easier for you to work with your medical team to make a plan to manage your side effects.. ...
Robert S. Brown, Jr., MD, MPH, FAASLD - American Liver FoundationRobert S. Brown, Jr., MD, MPH, FAASLD - American Liver Foundation
I am a board-certified medical oncologist who treats patients with gastrointestinal cancers. My specialization is in primary liver cancer (hepatocellular carcinoma), pancreas, gallbladder, and bile duct tumors. As part of a multidisciplinary group, my colleagues and I offer patients a team approach to treating these cancers.
Plus itPlus it
Purpose: MEK inhibition has clinical activity against biliary cancers, and might therefore be successfully combined with gemcitabine; one of the most active chemotherapy agents for these cancers. As gemcitabine is active in S-phase, and the ERK pathway has a major role driving cell cycle progression, concurrent use of a MEK inhibitor could potentially antagonize the effect of gemcitabine. We therefore tested the sequence dependence of the combination of gemcitabine and the MEK inhibitor AZD6244 using a series of biliary cancer models. Experimental Design: Primary xenografts were established from patients with gallbladder and distal bile duct cancer, and grown in SCID mice at the subcutaneous site. Plasma and tumor drug levels, and the time course for recovery of ERK signaling and S-phase were measured in tumor-bearing mice treated for 48hr with AZD6244 and then monitored for 48hr off treatment. Based on these results, two different treatment schedules combining AZD6244 with gemcitabine were ...
Bellini duct carcinoma: Review of diagnosis and management | SpringerLinkBellini duct carcinoma: Review of diagnosis and management | SpringerLink
Aim: To review the world literature on the histogenesis, diagnosis and management of Bellini duct carcinoma and to suggest a possible clinical algorithm to assist in their identification and appropria
A Randomized Phase 2 Study of Atezolizumab in Combination With Cobimetinib Versus Atezolizumab Monotherapy in Participants With...A Randomized Phase 2 Study of Atezolizumab in Combination With Cobimetinib Versus Atezolizumab Monotherapy in Participants With...
This phase II trial studies how well atezolizumab with or without cobimetinib works in treating patients with bile duct cancer that has spread to other places
Inventory updated | The Sterile EyeInventory updated | The Sterile Eye
2008 is soon a wrap, and its time to update my list of the different diagnostic and cancer treatment videos Ive filmed for the www.oncolex.no project over the last three and a half years. The project is almost completed, but I still have some filming related to liver-, pancreatic-, gall bladder- and bile duct cancer…
Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma...Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma...
TY - JOUR. T1 - Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma. AU - Sato, Yuya. AU - Ojima, Hidenori. AU - Onaya, Hiroaki. AU - Mori, Taisuke. AU - Hiraoka, Nobuyoshi. AU - Kishi, Yoji. AU - Nara, Satoshi. AU - Esaki, Minoru. AU - Shimada, Kazuaki. AU - Kosuge, Tomoo. AU - Sugihara, Kenich. AU - Kanai, Yae. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Aim: Prognosis of hypervascular cholangiocellular carcinoma (h-CCC) is reportedly better than that of ordinary hypovascular CCC (o-CCC). The aim of this study is to clarify the histopathological characteristics of h-CCC. Methods: On the basis of the findings in the arterial phase of contrast-enhanced computed tomography, 16 cases of mass-forming-type CCC were divided into two groups (h-CCC, n=8; o-CCC, n=8). Areas of high (Area H-a) and low (Area H-b) attenuation in h-CCC cases and areas of low attenuation in o-CCC cases (Area O) were delineated. These areas were then ...
Surgery for bile duct cancer - Canadian Cancer SocietySurgery for bile duct cancer - Canadian Cancer Society
Surgery is the main treatment for extrahepatic bile duct cancer, when possible. Surgery is used to: potentially cure resectable extrahepatic bile duct cancer by completely removing it Surgery is the most effective treatment for extrahepatic bile duct cancer. reduce pain or relieve symptoms or blocka
IJMS | Free Full-Text | RNA Interference Targeting Slug Increases Cholangiocarcinoma Cell Sensitivity to Cisplatin via...IJMS | Free Full-Text | RNA Interference Targeting Slug Increases Cholangiocarcinoma Cell Sensitivity to Cisplatin via...
Slug is an E-cadherin repressor and a suppressor of PUMA (p53 upregulated modulator of apoptosis) and it has recently been demonstrated that Slug plays an important role in controlling apoptosis. In this study, we examined whether Slugs ability to silence expression suppresses the growth of cholangiocarcinoma cells and/or sensitizes cholangiocarcinoma cells to chemotherapeutic agents through induction of apoptosis. We targeted the Slug gene using siRNA (Slug siRNA) via full Slug cDNA plasmid (Slug cDNA) transfection of cholangiocarcinoma cells. Slug siRNA, cisplatin, or Slug siRNA in combination with cisplatin, were used to treat cholangiocarcinoma cells in vitro. Western blot was used to detect the expression of Slug, PUMA, and E-cadherin protein. TUNEL, Annexin V Staining, and cell cycle analysis were used to detect apoptosis. A nude mice subcutaneous xenograft model of QBC939 cells was used to assess the effect of Slug silencing and/or cisplatin on tumor growth. Immunohistochemical staining was used
Measurement of the Invasion Depth of Extrahepatic Bile Duct Carcinoma: An Alternative Method Overcoming the Current T...Measurement of the Invasion Depth of Extrahepatic Bile Duct Carcinoma: An Alternative Method Overcoming the Current T...
Tumor staging of extrahepatic bile duct (EBD) carcinoma is problematic for a number of reasons, including definitional problems with the current T classification of the American Joint Committee on Cancer staging system and the common occurrence of severe desmoplastic stromal reaction around the adva
Bile Duct Cancer (Cholangiocarcinoma) Resources - Navigating CareBile Duct Cancer (Cholangiocarcinoma) Resources - Navigating Care
What is Bile Duct Cancer (Cholangiocarcinoma)? Get the facts about Bile Duct Cancer (Cholangiocarcinoma) symptoms, testing, treatment and care options from trusted sources.
Carcinoma of the extrahepatic bile ducts<...Carcinoma of the extrahepatic bile ducts<...
TY - JOUR. T1 - Carcinoma of the extrahepatic bile ducts. AU - Wei, T. C.. AU - Wei, P. L.. AU - Yu, S. C.. AU - Lee, P. H.. AU - Hsu, S. C.. PY - 1995. Y1 - 1995. N2 - Fifty-two patients with carcinoma of the extrahepatic bile ducts were reviewed. There were 28 men and 24 women whose ages ranged from 31 to 78 years, with a mean age of 58 years. Symptoms, signs and laboratory results were primarily the result of bile duct obstruction. The most valuable diagnostic procedures were percutaneous transhepatic cholangiography and endoscopic retrograde cholangiopancreatography. In 28 patients the tumor was located in the upper, 9 in the middle and 12 in the lower common bile duct. In the other three patients the tumor was diffuse. The resectability rate was 21.2% (11/52). Of the remaining patients, 10 (19.2%) had T-tube drainage, 5 (9.6%) had biliary digestive anastomosis, 18 (34.6%) had percutaneous transhepatic biliary drainage and 8 (15.4%) had biopsy only. The histologic diagnosis was sclerosing in ...
Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Review, H1 2016 : ReportsnReportsBile Duct Cancer (Cholangiocarcinoma) - Pipeline Review, H1 2016 : ReportsnReports
[504 Pages Report] Check for Discount on Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Review,...
SciCombinator - Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancerSciCombinator - Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
Comments, concepts and statistics about Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer.
Identification of Cholangiocarcinoma by Using the Spyglass Spyscope System for Peroral Cholangioscopy and Biopsy CollectionIdentification of Cholangiocarcinoma by Using the Spyglass Spyscope System for Peroral Cholangioscopy and Biopsy Collection
Background and Aims: It is a challenge to collect samples from bile duct strictures to diagnose patients with cholangiocarcinoma. We investigated the utility of the Spyglass Spyscope, a single-operator endoscope that is used to perform cholangiopancreatoscopy, to identify extrahepatic cholangiocarcinoma in patients who were not diagnosed with this disorder by endoscopic retrograde cholangiopancreatography (ERCP) cytology or endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) analyses. Methods: We conducted a retrospective analysis of data from 30 patients (median age, 67 years; 67percent male) with indeterminate extrahepatic biliary strictures who were ultimately diagnosed with cholangiocarcinoma but had inconclusive results from initial biliary ductal brush cytology and EUS-FNA analyses. Patients then underwent cholangioscopy by using the Spyglass Spyscope and intraductal biopsy analysis. None of the patients had a definitive mass in abdominal imaging or EUS analyses. Results: The ...
Cholangiocarcinoma (Bile Duct Cancer) - Jefferson University HospitalsCholangiocarcinoma (Bile Duct Cancer) - Jefferson University Hospitals
Cholangiocarcinoma, also known as bile duct cancer, is often treated the same way as hepatocellular carcinoma, the most common form of primary liver cancer that develops in the main type of liver cell.
Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®) (Patients) - Siteman Cancer CenterBile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®) (Patients) - Siteman Cancer Center
Learn more about Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®) (Patients) from the National Cancer Institute at Siteman Cancer Center.
Bile Duct Cancer (Cholangiocarcinoma) | Cleveland ClinicBile Duct Cancer (Cholangiocarcinoma) | Cleveland Clinic
Learn about bile duct cancer (cholangiocarcinoma) from the Cleveland Clinic, including information on treatment options, stages & more.
Diabetes Drugs - Bile Duct Cancer / Cholangiocarcinoma - Side EffectsDiabetes Drugs - Bile Duct Cancer / Cholangiocarcinoma - Side Effects
Diabetes drugs in dipeptidyl peptidase-4 (DPP-4) inhibitor class can double risks of developing bile duct cancer, also known as cholangiocarcinoma
Molecules and CellsMolecules and Cells
Cholangiocarcinoma is a malignant tumor that originates from the bile duct epithelium (Roberts et al., 1997). Based on its anatomical location in the biliary tree, cholangiocarcinoma is conventionally classified by the World Health Organization as an intrahepatic (ICC) or extrahepatic cholangiocarcinoma (ECC) (Bosman et al., 2010; Patel, 2011). ICC and ECC are biologically distinct, and therefore manifest substantial differences in terms of incidence, mortality, and risk factors (Cardinale et al., 2010). Cholangiocarcinoma has a poor prognosis because it is notoriously difficult to diagnose due to its late clinical presentation, and is refractory to conventional chemotherapy and radiation therapy (Blechacz and Gores, 2008; Blechacz et al., 2011; Khan et al., 2012). Gemcitabine and cisplatin has become the standard regimen for patients with advanced or metastatic cholangiocarcinoma (Ramirez-Merino et al., 2013; Valle et al., 2010). However, response to the combination chemotherapy in ...
Bile duct cancer, X-ray - Stock Image M134/0418 - Science Photo LibraryBile duct cancer, X-ray - Stock Image M134/0418 - Science Photo Library
Bile duct cancer. Coloured angiogram (X-ray) of a patients common bile duct (dark red, centre right) that has been blocked by cancer. The cancer (not seen) has caused a narrowing, or stricture, of the duct. A stent (fine mesh tube, lower frame) has been permanently inserted into the duct to correct the stricture. A tube (catheter) inside the stent will be removed when fluid has drained from the duct. Bile fluid, secreted by the liver cells, emulsifies ingested fats. It drains into the small intestine through the common bile duct when food enters the intestine. A contrast medium injected into the duct makes it visible on X-ray. - Stock Image M134/0418
Bile duct stricture | Radiology Case | Radiopaedia.orgBile duct stricture | Radiology Case | Radiopaedia.org
Bile duct strictures are either benign or malignant. Malignant strictures are usually short and irregular with shouldering margins, as in this case. This suggests the diagnosis of hilar cholangiocarcinoma (Klatskin tumor), but there is no pathol...
Johns Hopkins Medicine: WeissJohns Hopkins Medicine: Weiss
Matthew Weiss, MD, FACS, specializes in surgery for pancreatic and liver cancer, as well as benign hepatopancreatobiliary diseases, including cystic lesions of the pancreas. In addition to performing the Whipple procedure, he has particular expertise in minimally invasive pancreatic resections. Dr. Weiss clinical interests also include colorectal metastases to the liver, hepatocellular carcinomas, intrahepatic cholangiocarcinomas, bile duct cancers (Klatskin tumors), intraductal papillary mucinous neoplasms of the pancreas, neuroendocrine tumors, and gallbladder cancers. ...
Plus itPlus it
p16Ink4 and p15Ink4B are cyclin-dependent kinase 4 inhibitors and link to the regulation of cell cycle in mammalian cells. The genes encoding these inhibitors are located at 9p21, which is a frequent site of allelic loss in various types of tumors. Twenty-five primary biliary tract cancers were examined for somatic mutations in p16Ink4/CDKN2, p15Ink4B/MTS2, p53, and K-ras genes and allelic loss of 9p21 by microsatellite analysis. Four biliary tract cancer cell lines were analyzed for homozygous deletions and point mutations. We found frequent homozygous deletions in p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in the biliary tract cancer cell lines. Each cancer cell line had alteration of either p16Ink4/CDKN2, p15Ink4B/MTS2, or p53 genes. In primary tumors, 16 of 25 (64%) biliary tract cancers had point mutations in the p16Ink4/CDKN2 gene. These include 14 missense and 2 silent mutations. The frequency of mutations in gall bladder cancer and hilar bile duct cancer were 80% (8 of 10) and 63% (5 of 8), ...
Functional Glycomics by Minoru Fukuda - Le Camp de Raborak E-booksFunctional Glycomics by Minoru Fukuda - Le Camp de Raborak E-books
Biophys. Acta. 1573, 388-393. , Muller, W. , and Dennis, J. W. (2000). Suppression of tumor growth and metastasis in Mgat5‐deficient mice. Nat. Med. 6, 306-312. Haltiwanger, R. , and Lowe, J. B. (2004). Role of glycosylation in development. Annu. Rev. Biochem. 73, 491-537. , and Taniguchi, N. (1996). Transcriptional regulation of the N‐acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC‐T1) is mediated by Ets‐1. J. Biol. Chem. 271, 26706-26712. Lowe, J. , and Marth, J. 6, 306-312. Haltiwanger, R. , and Lowe, J. B. (2004). Role of glycosylation in development. Annu. Rev. Biochem. 73, 491-537. , and Taniguchi, N. (1996). Transcriptional regulation of the N‐acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC‐T1) is mediated by Ets‐1. J. Biol. Chem. 271, 26706-26712. Lowe, J. , and Marth, J. D. (2003). A genetic approach to Mammalian glycan function. Annu. Rev. Biochem. 72, 643-691. , Hoodless, P. , and Wrana, J. L. (1996). MADR2 is a ...
Liver and intrahepatic bile ducts - tumor - Follicular lymphomaLiver and intrahepatic bile ducts - tumor - Follicular lymphoma
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Liver and intrahepatic bile ducts - tumor - GrossingLiver and intrahepatic bile ducts - tumor - Grossing
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Rare Cancer News & Clinical Trials » Trial - Bile Duct Cancer » A Study of Merestinib (LY2801653) in Japanese Participants With...Rare Cancer News & Clinical Trials » Trial - Bile Duct Cancer » A Study of Merestinib (LY2801653) in Japanese Participants With...
Rare Cancer News & Clinical Trials » Trial - Bile Duct Cancer » A Study of Merestinib (LY2801653) in Japanese Participants With Advanced or Metastatic ...
SearchSearch
Evidence on the association between physical activity and risk of hepatobiliary cancers is inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting ,2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity ...
SearchSearch
Evidence on the association between physical activity and risk of hepatobiliary cancers is inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting ,2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity ...
Best Cholangiocarcinoma Doctor in Kolkata, Cholangiocarcinoma Doctors | CredihealthBest Cholangiocarcinoma Doctor in Kolkata, Cholangiocarcinoma Doctors | Credihealth
Find the best cholangiocarcinoma doctors in Kolkata. Get guidance from medical experts to select cholangiocarcinoma specialist in Kolkata from trusted hospitals - credihealth.com
Clinical manifestations and diagnosis of cholangiocarcinomaClinical manifestations and diagnosis of cholangiocarcinoma
Cholangiocarcinomas (bile duct cancers) arise from the epithelial cells of the bile ducts. Although they are rare in the United States, these cancers are highly lethal because most are locally advanced at presentation. (See.)The clinical manifestatio
Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®) (Patients) | OncoLinkBile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®) (Patients) | OncoLink
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Bile Duct Cancer (Cholangiocarcinoma) Groups - Navigating CareBile Duct Cancer (Cholangiocarcinoma) Groups - Navigating Care
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On october 29, 2010 my mother died of cholangiocarcinomaOn october 29, 2010 my mother died of cholangiocarcinoma
My mother died of Cholangiocarcinoma. This is a very uncommon cancer of the bile duct. I have since that day, started this site. Not until today did I look up Cholangiocarcinoma specifically. What I just found astounds me... Was Mom taking a trial drug? A drug that wasnt even approved by the FDA? She…
Targeted Treatment Advances in Cholangiocarcinoma - The ASCO PostTargeted Treatment Advances in Cholangiocarcinoma - The ASCO Post
Safety Profile. The most common treatment-related adverse events among all patients who received ivosidenib (including after crossover) included nausea (32.1%), diarrhea (28.8%), fatigue (23.7%), cough (19.2%), abdominal pain (18.6%), ascites (18.6%), decreased appetite (17.3%), anemia (16.0%), and vomiting (16.0%). Grade 3 adverse events were reported in 46% of patients treated with ivosidenib compared to 36% of patients treated with placebo. More of the placebo arm (8.5% vs. 5.8%) discontinued treatment due to toxicity, and ivosidenib was associated with better physical and emotional functioning on quality-of-life measures.. "These pivotal data demonstrate the clinical relevance and benefit of ivosidenib in patients with IDH1-mutated cholangiocarcinoma and establish the role for genomic testing in this rare cancer with a high unmet need," Dr. Abou-Alfa said. All patients with cholangiocarcinoma should be tested for the IDH1 mutation, he maintained.. FIGHT-202. FIGHT-202 was a global, ...
Clinical Lecture on Malignant Stricture of the Hepatic Flexure of the Colon | The BMJClinical Lecture on Malignant Stricture of the Hepatic Flexure of the Colon | The BMJ
Thank you for your interest in spreading the word about The BMJ.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
barbie - Patient: Bile Duct (Cholangiocarcinoma) Cancer- Newly diagnosed (has not begun treatment)barbie - Patient: Bile Duct (Cholangiocarcinoma) Cancer- Newly diagnosed (has not begun treatment)
barbie - Patient: Bile Duct (Cholangiocarcinoma) Cancer Patient Info: Newly diagnosed (has not begun treatment), Diagnosed: over 7 years ago, Female, Age: 65
DMOZ - Health: Conditions and Diseases: Cancer: Gastrointestinal: Extrahepatic Bile DuctDMOZ - Health: Conditions and Diseases: Cancer: Gastrointestinal: Extrahepatic Bile Duct
A rare disease in which malignant (cancer) cells form in the part of bile duct that is outside the liver. Also known as Cholangiocarcinoma.
Liver and Bile Duct Cancer | Natural Treatments at CancerTutor.comLiver and Bile Duct Cancer | Natural Treatments at CancerTutor.com
As part of the digestive system, bile ducts help digest food properly. If cancer spreads to the liver, the chemical balance of the body will be disturbed.
Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells - Fingas - 2011 - Hepatology -...Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells - Fingas - 2011 - Hepatology -...
This work was supported by National Institutes of Health (NIH; Bethesda, MD) grants NIH DK59427 (to G.J.G.), NIH R01 CA 83650, R01 CA 39225 (to A.E.S.), the optical microscopy, clinical, and genetics core of NIH DK84567, and the Mayo Foundation. C.D.F. is a German Research Foundation fellow (Deutsche Forschungsgemeinschaft; grant FI 1630/1-1). ...
Bile Duct Cancer: Chemotherapy - Nebraska MedicineBile Duct Cancer: Chemotherapy - Nebraska Medicine
Its important to know which medicines youre taking. Write your medicines down, ask your healthcare team how they work, and what side effects they might have. Keep a written diary of your treatment schedule and any signs or symptoms you have.. Talk with your healthcare providers about what signs to look for, and when to call them. Chemotherapy can make you more likely to get infections.. It may be helpful to keep a diary of your side effects. Write down physical, thinking, and emotional changes. A written list will make it easier for you to remember your questions when you go to your appointments. It will also make it easier for you to work with your medical team to make a plan to manage your side effects.. ...
Bile Duct Cancer | Roswell Park Comprehensive Cancer CenterBile Duct Cancer | Roswell Park Comprehensive Cancer Center
Am I pooping enough? Why is my poop green?" Seemingly silly questions like these are, in fact, important to understanding your body. The bowel movement chart below will help you decode your stool and discover helpful insights into your health. Keep in mind that everyones body is different and only a medical professional can evaluate your individual symptoms and observations.. ...
Metastin Receptor - Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist blocks HIV entryMetastin Receptor - Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist blocks HIV entry
Background Cholangiocarcinoma (CC) is a malignant neoplasm of the bile ducts or the gallbladder. cell lines had been analyzed for KRAS mutations. Outcomes EGFR, IGFR1 and HGFR were within all cell lines tested. IGFR2 expression was verified in TFK-1 and EGI-1. No growth-inhibitory impact was within EGI-1 cells after incubation with cetuximab. Cetuximab inhibited development in TFK-1 dose-dependently. Elevated apoptosis was just seen in TFK-1 cells at the highest cetuximab dose tested (1 mg/ml), with no dose-response-relationship at lower concentrations. In EGI-1 a heterozygous KRAS mutation was found in codon 12 (c.35G>A; p.G12D). HuH28, OZ and TFK-1 lacked KRAS mutation. Conclusion CC cell lines express a pattern of AZD1480 different growth receptors in vitro. Growth factor inhibitor treatment could be affected from your KRAS genotype in CC. The expression of EGFR itself does not allow prognoses on growth inhibition by cetuximab. Background Cholangiocarcinoma (CC) is usually a malignant ...
PSC Partners Seeking a Cure PSC and PBC - PSC Partners Seeking a CurePSC Partners Seeking a Cure PSC and PBC - PSC Partners Seeking a Cure
In PSC, a key feature is the development of scar tissue (fibrosis) that predominantly affects the medium- to large-sized bile ducts within and outside the liver. This can most often be identified with a special MRI scan (called MRCP), although occasionally a liver biopsy is needed for confirmation. PSC can affect men and women at any age, although it is commonly diagnosed in the fourth decade of life, most often in the presence of inflammatory bowel disease (IBD) [2].. Close monitoring of PSC patients is vital. Because of the increased colon cancer risk in PSC patients with ulcerative colitis, annual colonoscopies are advised. Moreover, the presence of colitis is associated with a greater risk of liver disease progression and bile duct cancer (cholangiocarcinoma) [4]. Individuals with PSC can occasionally develop abdominal pain and fever, which may suggest infection of the bile ducts called cholangitis. Although the latter can be treated with antibiotics, no currently known treatment has been ...
cholangiocarcinoma Tags - SAGEScholangiocarcinoma Tags - SAGES
Endoscopic view of a choledochojejunal anastomosis in a patient who had a gastrointestinal bleed. A laparoscopic side-to-side choledochojejunostomy had been performed 2 months previously for an unresectable distal cholangiocarcinoma causing obstructive j ...
Clinical Trial Phase 2, Nab-Paclitaxel, Gemcitabine, Cisplatin - Cholangiocarcinoma Foundation Discussion BoardClinical Trial Phase 2, Nab-Paclitaxel, Gemcitabine, Cisplatin - Cholangiocarcinoma Foundation Discussion Board
Hello all,. My father (aged 57) was recently diagnosed with cholangiocarcinoma and they are not sure if it is operable. We have been offered a clinical trial regarding nab-paclitaxel, gemcitabine, and cisplatin. Have any of you had any experiences using this cocktail? Or know any information regarding it? We would love to know your thoughts/opinions before we decide to move forward.. ...
List of hepato-biliary diseasesList of hepato-biliary diseases
C22C22
List of MeSH codes (C04)List of MeSH codes (C04)
List of MeSH codes (C06)List of MeSH codes (C06)
Pancreatic serous cystadenomaPancreatic serous cystadenoma
Biliary diseaseBiliary disease
CholangiocarcinomaCholangiocarcinoma
ClonorchiasisClonorchiasis
NucleoporinNucleoporin
ICD-10 Chapter II: NeoplasmsICD-10 Chapter II: Neoplasms
Intraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasm
Intraductal papillary neoplasm of the bile ductIntraductal papillary neoplasm of the bile duct
List of ICD-9 codes 140-239: neoplasmsList of ICD-9 codes 140-239: neoplasms
Digestive system neoplasmDigestive system neoplasm
David B. AdamsDavid B. Adams
GastrinomaGastrinoma
Pancreatic massPancreatic mass
Liver cancerLiver cancer
List of cancer typesList of cancer types
HepatotoxicityHepatotoxicity
Pseudomyxoma peritoneiPseudomyxoma peritonei
Sarcoma botryoidesSarcoma botryoides
Pancreatic cancerPancreatic cancer
Index of oncology articlesIndex of oncology articles
ICD-10 Chapter XI: Diseases of the digestive systemICD-10 Chapter XI: Diseases of the digestive system
Juvenile polyposis syndromeJuvenile polyposis syndrome
Cronkhite-Canada syndromeCronkhite-Canada syndrome
Primary peritoneal carcinomaPrimary peritoneal carcinoma
Linitis plasticaLinitis plastica
CarcinoidCarcinoid
ಜಠರ/ಜಠರೀಯ ಹುಣ್ಣು/ವ್ರಣ - ವಿಕಿಪೀಡಿಯಜಠರ/ಜಠರೀಯ ಹುಣ್ಣು/ವ್ರಣ - ವಿಕಿಪೀಡಿಯ
PancreasPancreas
Polyp (medicine)Polyp (medicine)
Bowel obstructionBowel obstruction
Somatic evolution in cancerSomatic evolution in cancer
ThyroidThyroid
Gluten-sensitive enteropathy-associated conditionsGluten-sensitive enteropathy-associated conditions
胰臟癌 - 維基百科，自由的百科全書胰臟癌 - 維基百科，自由的百科全書
Small intestineSmall intestine
ಟೆಂಪ್ಲೇಟು:Congenital malformations and deformations of digestive system - ವಿಕಿಪೀಡಿಯಟೆಂಪ್ಲೇಟು:Congenital malformations and deformations of digestive system - ವಿಕಿಪೀಡಿಯ
Stem cell markerStem cell marker
List of ICD-9 codes 800-999: injury and poisoningList of ICD-9 codes 800-999: injury and poisoning
ThyroidThyroid
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Common Bile Duct NeoplasmsBile Duct NeoplasmsBile DuctsCommon Bile DuctBileBile Duct DiseasesBile Acids and SaltsBile Ducts, ExtrahepaticBile Ducts, IntrahepaticCommon Bile Duct DiseasesCholestasisPancreatic DuctsGallstonesAdenoma, Bile DuctCholangiopancreatography, Endoscopic RetrogradeHepatic Duct, CommonCholangiographyCholestasis, ExtrahepaticCystic DuctCholelithiasisThoracic DuctCholecystectomy, LaparoscopicJaundice, ObstructiveBiliary TractCholecystectomyBiliary Tract Surgical ProceduresCholangitisLigationCholedocholithiasisSphincterotomy, EndoscopicGallbladderPancreatic NeoplasmsBiliary Tract DiseasesSalivary DuctsLiverCholangiopancreatography, Magnetic ResonanceBile PigmentsAmpulla of VaterBile CanaliculiCholangiocarcinomaBiliary FistulaWolffian DuctsSphincter of OddiNeoplasmsCholestasis, IntrahepaticMullerian DuctsGallbladder NeoplasmsBile RefluxCholedochal CystLiver Cirrhosis, BiliaryBiliary AtresiaTaurocholic AcidNeoplasms, Cystic, Mucinous, and SerousCholedochostomyDrainagePancreatitisBiliary Tract NeoplasmsUrsodeoxycholic AcidBilirubinNeoplasms, Multiple PrimaryImmunohistochemistryCholangitis, SclerosingAdenocarcinoma, PapillaryCholic AcidsChenodeoxycholic AcidJejunostomyJaundiceLiver NeoplasmsKidney Tubules, CollectingCholagogues and CholereticsLiver DiseasesPancreaticoduodenectomyNasolacrimal DuctCystadenomaHepatectomySkin NeoplasmsCholecystitisLithiasisAnastomosis, Roux-en-YAdenocarcinoma, MucinousEjaculatory DuctsLithotripsyDilatation, PathologicRetrospective Studies1-NaphthylisothiocyanateCholic AcidDeoxycholic AcidEndoscopyIntraoperative ComplicationsIatrogenic DiseaseTomography, X-Ray ComputedSphincterotomy, TranshepaticAnastomosis, SurgicalLithocholic AcidTreatment OutcomePancreasKidney NeoplasmsPostoperative ComplicationsEndosonographyLiver Cirrhosis, ExperimentalDuodenal NeoplasmsCystsDuodenoscopyEndoscopesDuodenumCystadenoma, MucinousNeoplasms, Second PrimaryHepatic ArteryPancreatic DiseasesTaurodeoxycholic AcidTaurochenodeoxycholic AcidGallbladder DiseasesCystadenocarcinomaImino AcidsEnterohepatic CirculationConstriction, PathologicHepatocytesCatheterizationThyroid NeoplasmsEndoscopy, Digestive SystemAdenocarcinomaKlatskin's TumorLiver TransplantationPortal VeinCarcinoma, PapillaryCalculiMyeloproliferative DisordersDNA, NeoplasmLiver CirrhosisOrganic Anion Transporters, Sodium-DependentLiver Function TestsClonorchiasisLithotripsy, LaserCaroli DiseaseParotid NeoplasmsCarcinoma, Pancreatic DuctalVitelline DuctGlycocholic AcidKeratin-7Rats, Inbred F344Time FactorsEpitheliumLung NeoplasmsCholecystostomyLacrimal Duct ObstructionCholesterolCholecystographyNeoplasms, ExperimentalGastrointestinal NeoplasmsEndolymphatic DuctNeoplasms, Connective and Soft TissueRats, Sprague-DawleyNeoplasms, Plasma CellNeoplasm InvasivenessSalivary Gland NeoplasmsNeoplasms, Complex and MixedAppendiceal NeoplasmsTechnetium Tc 99m DisofeninNeoplasm StagingIntraoperative CareBiopsyOvarian NeoplasmsPancreatectomyEndocrine Gland NeoplasmsTumor Markers, BiologicalSphincter of Oddi DysfunctionDigestive System NeoplasmsCholecystitis, AcuteAdenomaDilatationDisease Models, AnimalFollow-Up StudiesCholesterol 7-alpha-HydroxylaseCarcinomaNeoplasm ProteinsDuodenal DiseasesNose NeoplasmsNeoplasms, Vascular TissueEpithelial CellsEye NeoplasmsPancreatitis, ChronicKeratinsDogsHamartomaDog DiseasesPortal SystemFatal OutcomeAntigens, NeoplasmNeoplasms, Radiation-InducedCystadenocarcinoma, MucinousCholecystolithiasisAdenoma, VillousFascioliasisTesticular NeoplasmsNeoplasms, Muscle TissueNeoplasms, Glandular and EpithelialSweat Gland NeoplasmsNervous System NeoplasmsIntestinal NeoplasmsSecretinLiver Neoplasms, Experimental
Intraductal papillary neoplasm of the bile duct - WikipediaIntraductal papillary neoplasm of the bile duct - Wikipedia
Intraductal papillary neoplasm in common bile duct opening into the stomachIntraductal papillary neoplasm in common bile duct opening into the stomach
Search of: Recruiting, Not yet recruiting, Available Studies | Bile Duct Neoplasms - Results on Map - ClinicalTrials.govSearch of: Recruiting, Not yet recruiting, Available Studies | 'Bile Duct Neoplasms' - Results on Map - ClinicalTrials.gov
Bile duct neoplasms Pathway Map - PrimePCR | Life Science | Bio-RadBile duct neoplasms Pathway Map - PrimePCR | Life Science | Bio-Rad
Common bile duct neoplasms | Article about Common bile duct neoplasms by The Free DictionaryCommon bile duct neoplasms | Article about Common bile duct neoplasms by The Free Dictionary
Erlotinib Completed Phase 1 Trials for Extrahepatic Bile Duct Cancer / Small Intestine Cancer / Gallbladder Cancer / Malignant...Erlotinib Completed Phase 1 Trials for Extrahepatic Bile Duct Cancer / Small Intestine Cancer / Gallbladder Cancer / Malignant...
CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas |...CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas |...
2020 ICD-10-CM Codes C22*: Malignant neoplasm of liver and intrahepatic bile ducts2020 ICD-10-CM Codes C22*: Malignant neoplasm of liver and intrahepatic bile ducts
Intraductal papillary neoplasm of the bile duct: Assessment of invasive carcinoma and long-term outcomes using MRI | SNFGE.org ...Intraductal papillary neoplasm of the bile duct: Assessment of invasive carcinoma and long-term outcomes using MRI | SNFGE.org ...
A previously undescribed form of intraductal papillary neoplasm of the bile duct. - Semantic ScholarA previously undescribed form of intraductal papillary neoplasm of the bile duct. - Semantic Scholar
Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the...Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the...
Common Bile Duct Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsCommon Bile Duct Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Bile Duct Neoplasms | Colorado PROFILESBile Duct Neoplasms | Colorado PROFILES
BILE DUCT NEOPLASMS | SelfDecode | Genome AnalysisBILE DUCT NEOPLASMS | SelfDecode | Genome Analysis
Intraductal Papillary Neoplasms of the Bile DuctIntraductal Papillary Neoplasms of the Bile Duct
Browsing Clinical Studies by subject Bile Duct NeoplasmsBrowsing Clinical Studies by subject "Bile Duct Neoplasms"
Intraductal Papillary Mucinous Neoplasms of the Bile Duct Treated with Argon Plasma Coagulation | Korean Journal of Pancreas...Intraductal Papillary Mucinous Neoplasms of the Bile Duct Treated with Argon Plasma Coagulation | Korean Journal of Pancreas...
Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma - Full Text View -...Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma - Full Text View -...
benign neoplasm of common bile duct 2005:2010[pubdate] *count=100 - BioMedLib™ search enginebenign neoplasm of common bile duct 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
extrahepatic bile duct neoplasm drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engineextrahepatic bile duct neoplasm drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
ICD-10 Diagnosis Code D13.5 Benign neoplasm of extrahepatic bile ductsICD-10 Diagnosis Code D13.5 Benign neoplasm of extrahepatic bile ducts
Diseases(malignant-neoplasm-of-liver-and-intrahepatic-bile-ducts) - Clinical PearlDiseases(malignant-neoplasm-of-liver-and-intrahepatic-bile-ducts) - Clinical Pearl
Research Profile Listing | Yale School of MedicineResearch Profile Listing | Yale School of Medicine
Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study<...Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study<...
Research Keyword Faculty Listing | Yale School of MedicineResearch Keyword Faculty Listing | Yale School of Medicine
Cholangiocarcinoma | Bile Duct Cancer: MedlinePlusCholangiocarcinoma | Bile Duct Cancer: MedlinePlus
GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct. - PubMed - NCBIGNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct. - PubMed - NCBI
Deaths(#), Malignant neoplasm of liver and intrahepatic bile ducts - European Health Information GatewayDeaths(#), Malignant neoplasm of liver and intrahepatic bile ducts - European Health Information Gateway
November 2012 - Volume 36 - Issue 11 : The American Journal of Surgical PathologyNovember 2012 - Volume 36 - Issue 11 : The American Journal of Surgical Pathology
Hayworth Cancer Center | Wake Forest Baptist HealthHayworth Cancer Center | Wake Forest Baptist Health
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Common Bile Duct NeoplasmsBile Duct NeoplasmsBile DuctsCommon Bile DuctBileBile Duct DiseasesBile Acids and SaltsBile Ducts, ExtrahepaticBile Ducts, IntrahepaticCommon Bile Duct DiseasesCholestasisPancreatic DuctsGallstonesAdenoma, Bile DuctCholangiopancreatography, Endoscopic RetrogradeHepatic Duct, CommonCholangiographyCholestasis, ExtrahepaticCystic DuctCholelithiasisThoracic DuctCholecystectomy, LaparoscopicJaundice, ObstructiveBiliary TractCholecystectomyBiliary Tract Surgical ProceduresCholangitisLigationCholedocholithiasisSphincterotomy, EndoscopicGallbladderPancreatic NeoplasmsBiliary Tract DiseasesSalivary DuctsLiverCholangiopancreatography, Magnetic ResonanceBile PigmentsAmpulla of VaterBile CanaliculiCholangiocarcinomaBiliary FistulaWolffian DuctsSphincter of OddiNeoplasmsCholestasis, IntrahepaticMullerian DuctsGallbladder NeoplasmsBile RefluxCholedochal CystLiver Cirrhosis, BiliaryBiliary AtresiaTaurocholic AcidNeoplasms, Cystic, Mucinous, and SerousCholedochostomyDrainagePancreatitisBiliary Tract NeoplasmsUrsodeoxycholic AcidBilirubinNeoplasms, Multiple PrimaryImmunohistochemistryCholangitis, SclerosingAdenocarcinoma, PapillaryCholic AcidsChenodeoxycholic AcidJejunostomyJaundiceLiver NeoplasmsKidney Tubules, CollectingCholagogues and CholereticsLiver DiseasesPancreaticoduodenectomyNasolacrimal DuctCystadenomaHepatectomySkin NeoplasmsCholecystitisLithiasisAnastomosis, Roux-en-YAdenocarcinoma, MucinousEjaculatory DuctsLithotripsyDilatation, PathologicRetrospective Studies1-NaphthylisothiocyanateCholic AcidDeoxycholic AcidEndoscopyIntraoperative ComplicationsIatrogenic DiseaseTomography, X-Ray ComputedSphincterotomy, TranshepaticAnastomosis, SurgicalLithocholic AcidTreatment OutcomePancreasKidney NeoplasmsPostoperative ComplicationsEndosonographyLiver Cirrhosis, ExperimentalDuodenal NeoplasmsCystsDuodenoscopyEndoscopesDuodenumCystadenoma, MucinousNeoplasms, Second PrimaryHepatic ArteryPancreatic DiseasesTaurodeoxycholic AcidTaurochenodeoxycholic AcidGallbladder DiseasesCystadenocarcinomaImino AcidsEnterohepatic CirculationConstriction, PathologicHepatocytesCatheterizationThyroid NeoplasmsEndoscopy, Digestive SystemAdenocarcinomaKlatskin's TumorLiver TransplantationPortal VeinCarcinoma, PapillaryCalculiMyeloproliferative DisordersDNA, NeoplasmLiver CirrhosisOrganic Anion Transporters, Sodium-DependentLiver Function TestsClonorchiasisLithotripsy, LaserCaroli DiseaseParotid NeoplasmsCarcinoma, Pancreatic DuctalVitelline DuctGlycocholic AcidKeratin-7Rats, Inbred F344Time FactorsEpitheliumLung NeoplasmsCholecystostomyLacrimal Duct ObstructionCholesterolCholecystographyNeoplasms, ExperimentalGastrointestinal NeoplasmsEndolymphatic DuctNeoplasms, Connective and Soft TissueRats, Sprague-DawleyNeoplasms, Plasma CellNeoplasm InvasivenessSalivary Gland NeoplasmsNeoplasms, Complex and MixedAppendiceal NeoplasmsTechnetium Tc 99m DisofeninNeoplasm StagingIntraoperative CareBiopsyOvarian NeoplasmsPancreatectomyEndocrine Gland NeoplasmsTumor Markers, BiologicalSphincter of Oddi DysfunctionDigestive System NeoplasmsCholecystitis, AcuteAdenomaDilatationDisease Models, AnimalFollow-Up StudiesCholesterol 7-alpha-HydroxylaseCarcinomaNeoplasm ProteinsDuodenal DiseasesNose NeoplasmsNeoplasms, Vascular TissueEpithelial CellsEye NeoplasmsPancreatitis, ChronicKeratinsDogsHamartomaDog DiseasesPortal SystemFatal OutcomeAntigens, NeoplasmNeoplasms, Radiation-InducedCystadenocarcinoma, MucinousCholecystolithiasisAdenoma, VillousFascioliasisTesticular NeoplasmsNeoplasms, Muscle TissueNeoplasms, Glandular and EpithelialSweat Gland NeoplasmsNervous System NeoplasmsIntestinal NeoplasmsSecretinLiver Neoplasms, Experimental
CancerTumorIntrahepatic bileCystic neoplasmsDilatationDuctalStricturesHepatic ductBiopsyDistal common bileIntraductal papillary neoplasmIPNBDiagnosisPancreatic ductsERCPDiseasesClinicalCommonTissueMain
Cancer26
Tumor5
Intrahepatic bile6
Cystic neoplasms5
Dilatation11
Ductal1
Strictures5
Hepatic duct7
Biopsy1
Distal common bile1
Intraductal papillary neoplasm8
IPNB3
Diagnosis2
Pancreatic ducts2
ERCP3
Diseases2
Clinical2
Common6
Tissue2
Main1
November 2012 - Volume 36 - Issue 11 : The American Journal of Surgical Pathology
November 2012 - Volume 36 - Issue 11 : The American Journal of Surgical Pathology (journals.lww.com)
Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic...
Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic... (onlinelibrary.wiley.com)
Cholangiocarcinoma | Bile Duct Cancer: MedlinePlus
Cholangiocarcinoma | Bile Duct Cancer: MedlinePlus (medlineplus.gov)
Safety and Efficacy of Modified Folfirinox Versus Gemcis in Bile Duct Tumours - Full Text View - ClinicalTrials.gov
Safety and Efficacy of Modified Folfirinox Versus Gemcis in Bile Duct Tumours - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Intraductal papillary neoplasm in common bile duct opening into the stomach
Intraductal papillary neoplasm in common bile duct opening into the stomach (medworm.com)
Transhepatic forceps biopsy combined with biliary drainage in obstructive jaundice: safety and accuracy | SpringerLink
Transhepatic forceps biopsy combined with biliary drainage in obstructive jaundice: safety and accuracy | SpringerLink (link.springer.com)
North Trauma Services, Minneapolis, MN
North Trauma Services, Minneapolis, MN (healthgrades.com)
Dr. Jason Taylor, MD - Reviews - Saint Louis, MO
Dr. Jason Taylor, MD - Reviews - Saint Louis, MO (healthgrades.com)
Virginia Mason Hospital & Seattle Medical Center, Seattle, WA
Virginia Mason Hospital & Seattle Medical Center, Seattle, WA (healthgrades.com)
Digestive Health Associates of Texas, P.A., Bedford, TX
Digestive Health Associates of Texas, P.A., Bedford, TX (healthgrades.com)
Dr. Erik Borncamp, MD | New Lenox, IL | Healthgrades
Dr. Erik Borncamp, MD | New Lenox, IL | Healthgrades (healthgrades.com)
WakeMed Physician Practices - Primary Care, Raleigh, NC, Raleigh, NC
WakeMed Physician Practices - Primary Care, Raleigh, NC, Raleigh, NC (healthgrades.com)
Dr. Thomas Rohs, MD | Kalamazoo, MI | Healthgrades
Dr. Thomas Rohs, MD | Kalamazoo, MI | Healthgrades (healthgrades.com)
Dr. Bruce Bennett, MD | Robbinsdale, MN | Healthgrades
Dr. Bruce Bennett, MD | Robbinsdale, MN | Healthgrades (healthgrades.com)
Main Line Gastroenterlgy Assocs, Havertown, PA
Main Line Gastroenterlgy Assocs, Havertown, PA (healthgrades.com)
Dr. Michael Townsend, MD | New Orleans, LA | Healthgrades
Dr. Michael Townsend, MD | New Orleans, LA | Healthgrades (healthgrades.com)
Dr. Wichit Srikureja, MD | Spokane, WA | Healthgrades
Dr. Wichit Srikureja, MD | Spokane, WA | Healthgrades (healthgrades.com)
Dr. Rahul Verma, MD - Reviews - San Carlos, CA
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Dr. Stephen Sears, MD - Reviews - Loveland, CO
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Galina Levin | Memorial Sloan Kettering Cancer Center
Galina Levin | Memorial Sloan Kettering Cancer Center (mskcc.org)