OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
BiguanidesPhenforminMetforminDisinfectantsContact Lens SolutionsChlorhexidineHypoglycemic AgentsProguanilSparteineAcanthamoebaAcanthamoeba KeratitisAmebicidesAcidosis, LacticSulfonylurea CompoundsMephenytoinAnti-Infective Agents, LocalTitrimetryAdenylate KinaseContact Lenses
Biguanides
Phenformin
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Metformin
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
Disinfectants
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Contact Lens Solutions
Sterile solutions used to clean and disinfect contact lenses.
Chlorhexidine
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
Hypoglycemic Agents
Substances which lower blood glucose levels.
Proguanil
A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
Sparteine
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
Acanthamoeba
A genus of free-living soil amoebae that produces no flagellate stage. Its organisms are pathogens for several infections in humans and have been found in the eye, bone, brain, and respiratory tract.
Acanthamoeba Keratitis
Infection of the cornea by an ameboid protozoan which may cause corneal ulceration leading to blindness.
Amebicides
Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.
Acidosis, Lactic
Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
Sulfonylurea Compounds
Mephenytoin
An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
Titrimetry
The determination of the concentration of a given component in solution (the analyte) by addition of a liquid reagent of known strength (the titrant) until an equivalence point is reached (when the reactants are present in stoichiometric proportions). Often an indicator is added to make the equivalence point visible (e.g., a change in color).
Adenylate Kinase
An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC 2.7.4.3.
Contact Lenses
Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)

Disinfection of upper gastrointestinal fibreoptic endoscopy equipment: an evaluation of a cetrimide chlorhexidine solution and glutaraldehyde. (1/239)

There is little information available on the bacteriological contamination of upper gastrointestinal fibreoptic endoscopes during routine use and the effects of 'disinfecting solutions'. A bacteriological evaluation was therefore made of cleaning an endoscope and its ancillary equipment with (1) water, (2) an aqueous solution of 1% cetrimide with 0.1% chlorhexidine, and (3) activated aqueous 2% glutaraldehyde. All equipment, but particularly the endoscope itself, was found to be heavily contaminated after use with a wide variety of organisms of which 53% were Gram positive. Cleaning the endoscope and ancillary equipment with water and the cetrimide/chlorhexidine solution alone or in combination was inadequate to produce disinfection but immersion in glutaraldehyde for two minutes consistently produced sterile cultures with our sampling technique. A rapid and simple method for disinfection of endoscopic equipment is therefore recommended and we think this is especially suitable for busy endoscopy units.  (+info)

Spermine and arcaine block and permeate N-methyl-D-aspartate receptor channels. (2/239)

Polyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-D-aspartate)-type glutamate receptors. Polyamine block of NMDA receptors was studied in excised outside-out patches from rat hippocampal neurons and Xenopus oocytes expressing recombinant receptors. Extracellular spermine and arcaine reduced NMDA single-channel conductance in a voltage-dependent manner, with partial relief of block evident at large inside negative membrane potentials. Reducing extracellular Na+ concentration increased the apparent affinities for spermine and arcaine, indicating strong interaction between spermine and permeant ions. Internal spermine also blocked NMDA channels in a voltage-dependent manner, with relief of block evident at large inside positive potentials. The Woodhull model of channel block by an impermeant ion adequately described the actions of external spermine from -60 to +60 mV, but failed for more negative potentials. Eyring rate theory for a permeable blocker with two barriers and one binding site adequately described the voltage-dependent block and relief from block by both external and internal spermine over the range of -120 to +60 mV. These findings indicate that polyamines block and permeate neuronal NMDA receptor channels from the extracellular and intracellular sides, although sensitivity to internal spermine is probably too low to be physiologically relevant.  (+info)

Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection? (3/239)

AIMS: This study characterised the pharmacology of [3H]-ifenprodil binding to the polyamine binding sites (PBS) on the N-methyl-D-aspartate (NMDA) receptor channel complex on human retinas. These data were correlated with the known neuroprotective effects of ifenprodil and eliprodil. METHODS: Specific binding of [3H]-ifenprodil (under sigma site blockade) was investigated using human retinal homogenates and radioligand binding techniques. Scatchard and competition analyses were utilised to define the pharmacology of the [3H]-ifenprodil binding sites. RESULTS: Specific binding of [3H]-ifenprodil comprised 73% (SEM 3%) of total and reflected interaction with two affinity sites (Kds = 0.39 and 4.3 microM) of different densities (Bmax = 14.4 and 105 pmol/mg protein) (n = 5). The rank order of affinity of compounds competing for [3H]-ifenprodil binding to the high affinity PBS was: ifenprodil > eliprodil > arcaine > spermine > diaminodecane > spermidine > putrescine >> MK-801 (n = 3-7). However, [3H]-ifenprodil binding was minimally inhibited by glutamate, NMDA, and kainate. CONCLUSION: These studies have shown, for the first time, the presence of specific [3H]-ifenprodil binding sites in the human retina with pharmacological characteristics of PBS associated with the NMDA receptor ionophore complex. The neuroprotective effects of eliprodil and ifenprodil may, in part, be mediated via these [3H]-ifenprodil labelled sites.  (+info)

Modulation of afferent-evoked neurotransmission by 5-HT3 receptors in young rat dorsal horn neurones in vitro: a putative mechanism of 5-HT3 induced anti-nociception. (4/239)

1. The in vitro hemisected spinal cord from young rat was used to investigate the mechanism of serotoninergic modulation of primary afferent-mediated synaptic transmission in the dorsal horn through activation of the 5-HT3 receptor. 2. Dorsal root-evoked excitatory post-synaptic potentials (DR-EPSPs) were recorded intracellularly from dorsal horn neurones. Extracellular recordings of the population primary afferent depolarization (PAD) and the dorsal root-evoked dorsal root reflex (DR-DRR) were made from segmental dorsal roots. 3. 5-Hydroxytryptamine (5-HT) and the selective 5-HT3 receptor agonist 1-(m-chloro-phenyl)-biguanide hydrochloride (m-ChPB) (10 and 50 microM) induced statistically significant reductions of the DR-EPSP amplitude (P<0.001) and duration (P<0.001) in the majority of dorsal horn neurones. The 5-HT3 receptor selective antagonists 3-Tropanyl-indole-3-carboxylate hydrochloride (Tropisetron, 10 microM) and N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1 ,4-benzoxazine-8-carboxamide (Y-25130, 10 microM) abolished m-ChPB-induced DR-EPSP attenuation and partially blocked the 5-HT effect. 4. m-ChPB (50 microM)-induced DR-EPSP amplitude and duration attenuation was retained in the presence of the GABA(A) receptor antagonist bicuculline (30 microM), the GABA(B) receptor antagonist saclofen (50 microM) and the opioid receptor antagonist naloxone (50 microM). 5. Both 5-HT and m-ChPB (10 and 50 microM) induced a PAD but the mean peak amplitude of 5-HT-induced PAD was significantly greater than PAD to m-ChPB (98.6+/-12 microV compared to 51.8+/-10 V for 50 microM of agonist, respectively). Tropisetron partially reduced 5-HT-induced PAD and abolished m-ChPB-induced PAD. 5-HT, but not m-ChPB, significantly (P<0.001) reduced the peak amplitude of the DR-DRR and this action of 5-HT was unaffected by Tropisetron or Y-25130. 6. These data provide experimental evidence for a putative cellular mechanism at the level of the dorsal horn for anti-nociceptive effects of 5-HT3 receptor activation. This 5-HT3-mediated modulation of sensory afferent transmission was evidently independent of inhibitory GABA- or opioid-dependent interneuronal pathways. The extent to which the 5-HT3 receptor could be involved in the operation of endogenous analgesia and sensory modulation by descending monoamine bulbo-spinal pathways is discussed.  (+info)

Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats. (5/239)

Neurochemical studies indicate that methamphetamine increases central serotonin (5-HT) levels more markedly than other psychomotor stimulants such as amphetamine or cocaine. In the present study, we investigated 5-HT involvement in the discriminative stimulus effects of methamphetamine. In Sprague-Dawley rats trained to discriminate 1.0 mg/kg methamphetamine i.p. from saline under a fixed-ratio schedule of food presentation, the effects of selected 5-HT agonists, antagonists, and uptake inhibitors were tested. Fluoxetine (1.8-18.0 mg/kg) and clomipramine (3.0-18.0 mg/kg), selective serotonin uptake inhibitors, did not produce any methamphetamine-like discriminative stimulus effects when administered alone, but fluoxetine (5.6 mg/kg), unlike clomipramine (5.6 mg/kg), significantly shifted the methamphetamine dose-response curve to the left. Both 8-hydroxy-2-dipropylaminotetralin (0.03-0.56 mg/kg), a full agonist, and buspirone (1.0-10.0 mg/kg), a partial agonist at 5-HT(1A) receptors, partially generalized to the training dose of methamphetamine but only at high doses that decreased response rate. This generalization was antagonized by the coadministration of the 5-HT(1A) antagonist WAY-100635 (1.0 mg/kg). WAY-100635 (1.0 mg/kg) also partially reversed the leftward shift of the methamphetamine dose-response curve produced by fluoxetine. (+/-)-1-(2, 5-Dimethoxy-4-iodophenyl)-2-aminopropane (0.3 mg/kg), a 5-HT(2A/2C) agonist, shifted the methamphetamine dose-response curve to the left, and this leftward shift was antagonized by the coadministration of ketanserin (3.0 mg/kg), a 5-HT(2A/2C) antagonist. Ketanserin (3.0 mg/kg) also produced a shift to the right in the methamphetamine dose-response curve and completely reversed the leftward shift in the methamphetamine dose-response curve produced by fluoxetine. In contrast, tropisetron (1.0 mg/kg), a 5-HT(3) antagonist, produced a shift to the left of the methamphetamine dose-response curve, and this effect of tropisetron was antagonized by the coadministration of m-chlorophenyl-biguanide (1.8 mg/kg), a 5-HT(3) agonist. The present data suggest that the 5-HT system plays a modulatory role in the discriminative stimulus effects of methamphetamine. These effects appear to be mediated through 5-HT release and blockade of reuptake and subsequent activation of 5-HT(2A/2C) receptors, with limited involvement of other 5-HT receptor subtypes.  (+info)

The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. (6/239)

While homomers containing 5-HT(3A) subunits form functional ligand-gated serotonin (5-HT) receptors in heterologous expression systems (Jackson, M. B., and Yakel, J. L. (1995) Annu. Rev. Physiol. 57, 447-468; Lambert, J. J., Peters, J. A., and Hope, A. G. (1995) in Ligand-Voltage-Gated Ion Channels (North, R., ed) pp. 177-211, CRC Press, Inc., Boca Raton, FL), it has been proposed that native receptors may exist as heteromers (Fletcher, S., and Barnes, N. M. (1998) Trends Pharmacol. Sci. 19, 212-215). We report the cloning of a subunit 5-HT(3B) with approximately 44% amino acid identity to 5-HT(3A) that specifically modified 5-HT(3A) receptor kinetics, voltage dependence, and pharmacology. Co-expression of 5-HT(3B) with 5-HT(3A) modified the duration of 5-HT(3) receptor agonist-induced responses, linearized the current-voltage relationship, increased agonist and antagonist affinity, and reduced cooperativity between subunits. Reverse transcriptase-polymerase chain reaction in situ hybridization revealed co-localization of both 5-HT(3B) and 5-HT(3A) in a population of neurons in the amygdala, telencephalon, and entorhinal cortex. Furthermore, 5-HT(3A) and 5-HT(3B) mRNAs were expressed in spleen and intestine. Our data suggest that 5-HT(3B) might contribute to tissue-specific functional changes in 5-HT(3)-mediated signaling and/or modulation.  (+info)

Pulmonary oedema produced by scorpion venom augments a phenyldiguanide-induced reflex response in anaesthetized rats. (7/239)

1. The involvement of pulmonary oedema produced by scorpion venom in augmenting a phenyldiguanide (PDG)-induced reflex response was evaluated in urethane-anaesthetized rats. 2. PDG-induced bradycardiac, hypotensive and apnoeic responses, expressed as time-response area, exhibited similarities before or after venom treatment. Hence, the time-response area of bradycardia was taken as a reflex parameter. Pulmonary oedema was determined by physical evaporation and histological methods. 3. Exposure to Indian red scorpion (Buthus tamulus, BT; i.v.) venom for 30 min increased the pulmonary water content (P < 0.05; Student's t test) and augmented the PDG-induced bradycardiac reflex response by more than 2 times (P < 0.001). The increase of pulmonary water content was maximal with 100 microg kg-1 of venom and the augmentation was maximal with 10 microg kg-1. In a separate series of experiments, the venom (100 microg kg-1)-induced pulmonary oedema was confirmed by histological and physical methods. In this group also, the venom augmented the reflex to the same magnitude. 4. Pulmonary oedema (physical and histological) and augmentation of the bradycardiac reflex response after BT venom (100 microg kg-1; i.v.) were absent in animals pretreated with aprotinin, a kallikrein-kinin inhibitor (6000 KIU; i. v.). 5. Ondansetron (10 microg kg-1; i.v.), a 5-HT3 receptor antagonist, failed to block the venom-induced pulmonary oedema (physical and histological) but blocked the venom-induced augmentation of the reflex. 6. The results of this study indicate that the venom-induced augmentation of the PDG reflex is associated with pulmonary oedema involving kinins utilizing 5-HT3 receptors.  (+info)

The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain. (8/239)

Aromatic amino acids are important components of the ligand binding site in the Cys loop family of ligand-gated ion channels. To examine the role of tryptophan residues in the ligand binding domain of the 5-hydroxytryptamine(3) (5-HT(3)) receptor, we used site-directed mutagenesis to change each of the eight N-terminal tryptophan residues in the 5-HT(3A) receptor subunit to tyrosine or serine. The mutants were expressed as homomeric 5-HT(3A) receptors in HEK293 cells and analyzed with radioligand binding, electrophysiology, and immunocytochemistry. Mutation of Trp(90), Trp(183), and Trp(195) to tyrosine resulted in functional receptors, although with increased EC(50) values (2-92-fold) to 5-HT(3) receptor agonists. Changing these residues to serine either ablated function (Trp(90) and Trp(183)) or resulted in a further increase in EC(50) (Trp(195)). Mutation of residue Trp(60) had no effect on ligand binding or receptor function, whereas mutation of Trp(95), Trp(102), Trp(121), and Trp(214) ablated ligand binding and receptor function, and all but one of the receptors containing these mutations were not expressed at the plasma membrane. We propose that Trp(90), Trp(183), and Trp(195) are intimately involved in ligand binding, whereas Trp(95), Trp(102), Trp(121), and Trp(214) have a critical role in receptor structure or assembly.  (+info)

Indian Patents. 280055:A METHOD OF PREPARING BIGUANIDE DERIVATIVE
The compound of Formula 1 or a pharmaceutically acceptable salt thereof of Claim 1 wherein the compound of Formula 1 is N1-hexyl-N5-propyl biguanide; N1-hexyl-N5-cyclopropylmethyl biguanide; N1-hexyl-N5-cyclohexylmethyl biguanide; N1-hexyl-N5-benzyl biguanide; N1 N5-bis(4-chlorophenyl) biguanide; N1 N5-bis(3-chlorophenyl) biguanide; N1-(4-chloro)phenyl-N5-(4-methoxy)phenyl biguanide; N1 N5-bis(3-chloro-4-methoxyphenyl) biguanide; N1 N5-bis(3 4-dichlorophenyl) biguanide; N1 N5-bis(3 5-dichlorophenyl) biguanide; N1 N5-bis(4-bromophenyl) biguanide; N1-benzyl-N5-(pyridine-3-yl)methyl biguanide; N1-(phenethyl)-N5-propyl biguanide; N1-(phenethyl)-N5-cyclopropylmethyl biguanide; N1-(phenethyl)-N5-cycloheptyl biguanide; N1 N5-bis(phenethyl) biguanide; N1 N1 N5-trimethyl biguanide; N1 N1-dimethyl-N5-butyl biguanide; N1 N1-dimethyl-N5-(butan-2-yl) biguanide; N1 N1-dimethyl-N5-t-butyl biguanide; N1 N1-dimethyl-N5-pentyl biguanide; N1 N1-dimethyl-N5-methoxycarbonylethyl biguanide; N1 ...
https://www.allindianpatents.com/patents/280055-a-method-of-preparing-biguanide-derivative
EP 0841852 A4 20000621 - BIGUANIDE COMPOSITION AND METHOD FOR TREATING WATEREP 0841852 A4 20000621 - BIGUANIDE COMPOSITION AND METHOD FOR TREATING WATER
387444852 - EP 0841852 A4 2000-06-21 - BIGUANIDE COMPOSITION AND METHOD FOR TREATING WATER - [origin: WO9704655A1] A water treatment method for controlling the growth of algae, fungi and bacteria and the formation of a waterline residue in recreational and industrial water supplies containing turbulent water utilises a composition containing a polyhexamethylene biguanide compound and a surfactant. The water treatment method and composition containing the biguanide compound and surfactant are particularly useful for treating recreational water supplies like spas and swimming pools containing turbulent water, such as aerated water.[origin: WO9704655A1] A water treatment method for controlling the growth of algae, fungi and bacteria and the formation of a waterline residue in recreational and industrial water supplies containing turbulent water utilises a composition containing a polyhexamethylene biguanide compound and a surfactant. The water treatment method and composition containing the biguanide
https://data.epo.org/gpi/EP0841852A4-BIGUANIDE-COMPOSITION-AND-METHOD-FOR-TREATING-WATER
Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics - Fingerprint ...
Wilbur Johnson, Ivan Boyer, Jinqiu Zhu, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth ...
https://pennstate.pure.elsevier.com/en/publications/safety-assessment-of-polyaminopropyl-biguanide-polyhexamethylene-/fingerprints/
BIGUANIDE COMPOSITION WITH LOW TERMINAL AMINE - Patent applicationBIGUANIDE COMPOSITION WITH LOW TERMINAL AMINE - Patent application
0013]PHMB is a mixture of various biguanide polymers that can include different combinations of terminal groups, e.g., amine, cyanoguanidino, and guanidine. Based only on these three terminal groups, at least six possible biguanide polymers can exist. There can be one biguanide polymer with two terminal amine groups, which we refer to as PHMB-AA, one with two terminal cyanoguanidino groups, which we refer to as PHMB-CGCG, and one with two terminal guanidine groups, which we refer to as and PHMB-GG (see, below). There are also the three possible biguanide polymers having a combination of two different terminal groups. Again, based on the above terminal groups they include amine-cyanoguanidino (PHMB-ACG), amine-guanidino (PHMB-AG) and guanidine-cyanoguanidino (GCG). Accordingly, a commercial sample of PHMB will likely comprise a mixture of polymeric biguanides with the three mentioned terminal groups though how these terminal groups are arranged on each polymer and what the molar concentration of ...
http://www.patentsencyclopedia.com/app/20080261841
Resistance, biguanide sorption and biguanide-induced pentose leakage during encystment of Acanthamoeba castellanii -ORCAResistance, biguanide sorption and biguanide-induced pentose leakage during encystment of Acanthamoeba castellanii -ORCA
Aims: This study investigates the effects of biguanides during encystment of Acanthamoeba castellanii. Methods and Results: A non-nutrient encystment system was used to investigate the changes in the levels of sorption (uptake) of three non-cysticidal concentrations (10, 20 and 50 μg ml−1) of chlorhexidine diacetate (CHA) and polyhexamethylene biguanide (PHMB) as well as their effects on viability and leakage of pentose sugars during the first 36 h of encystment. Trophozoites treated with CHA or PHMB were more sensitive and generally sorbed more of each biocide than cysts. During encystment, the largest increases in resistance developed between 18 and 36 h for both biguanides with the resistance emerging to biguanide concentrations of 10 or 20 μg ml−1 between 18 and 24 h. At 50 μg ml−1 resistance emerged between 24 and 36 h. There was a general decrease in biocide sorption during encystment between 0-24 and 0-21 h for CHA and PHMB, respectively, at a concentration of 50 μg ml−1. The ...
https://orca.cf.ac.uk/62671/
Healthcare | Free Full-Text | Antifungal Effect of Non-Woven Textiles Containing Polyhexamethylene Biguanide with Sophorolipid:...Healthcare | Free Full-Text | Antifungal Effect of Non-Woven Textiles Containing Polyhexamethylene Biguanide with Sophorolipid:...
Tinea pedis is a preventable skin disease common in elderly or diabetic patients. Daily foot washing is effective for prevention, but can be difficult for many patients. Additionally, conventional methods cannot eliminate fungi within the stratum corneum, a common site for fungal invasion. This study investigates the antifungal effects, cytotoxicity, permeability, and efficacy of non-woven textiles containing polyhexamethylene biguanide (PHMB) mixed with sophorolipid. Permeability of PHMB with varying concentrations of sophorolipid was assessed via a cultured skin model. Stratum corneum PHMB concentration was quantified by polyvinylsulphuric acid potassium salt titration and cytotoxicity was assayed via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. Antifungal effects were evaluated via a new cultured skin/Trichophyton mentagrophytes model, with varying PHMB exposure duration. Clinically-isolated Trichophyton were applied to the feet of four healthy volunteers and then immediately treated
http://mdpi.com/2227-9032/2/2/183
Poly (Hexamethylene Biguanide) Hydrochloride 2% SolutionPoly (Hexamethylene Biguanide) Hydrochloride 2% Solution
**SOLD OUT. Website will be updated once it is in stock again.** Poly (Hexamethylene Biguanide) Hydrochloride is a polymer used as a sanitizer or preservative to kill bacteria. As a sanitizer, PHMB 2% solution is used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, to sterilize farm equipment, animal drinking water, and hard surfaces for food handling, to sterilize institutions such as hospitals and schools; and to deodorize vacuums machines and toilets. PHMB is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone. PHMB is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms. As a preservative, PHMB is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more. It is
https://allchemical.com.au/shop/polyhexamethylenebiguanide-hydrochloride-2-solution/
1-[3,5-Bis(trifluoromethyl)phenyl]biguanide hydrochloride - Alfa Chemistry1-[3,5-Bis(trifluoromethyl)phenyl]biguanide hydrochloride - Alfa Chemistry
1-[3,5-Bis(trifluoromethyl)phenyl]biguanide hydrochloride/ACM36068403 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
http://www.alfa-chemistry.com/cas_36068-40-3.htm
PHMB - Setting the record straight - ByotrolByotrolPHMB - Setting the record straight - ByotrolByotrol
One of the chemicals used in Byotrol technology is Polyhexamethylene biguanide hydrochloride (PHMB), a biocide that has been used widely for decades providing valuable disinfection, cleaning and hygiene functions in a wide selection of products such as cosmetics, deodorant, contact lenses solutions, fabric softeners, water treatments and wound care products. PHMB is an effective public health biocide supported under the Biocidal Products Directive in Europe and REACh*.. ECHA has reviewed all available data for PHMB including 30 year old rat feeding studies, where rats ingested 5 times their body weight of PHMB, and recommended that PHMB be classified and labelled on products where PHMB is included at ,1% as H351 - suspected of causing cancer. This classification is for biocidal (not cosmetic where it is permitted at certain levels for certain uses, or medical device) products in Europe and will not apply across other parts of the world.. One manufacturer of PHMB has stated they believe this ...
http://www.byotrol.co.uk/revised-classification-phmb/
Type 2 Diabetes Medication Biguanide | Metformin | GlucophageType 2 Diabetes Medication Biguanide | Metformin | Glucophage
What are biguanides? How do biguanides control blood sugar? What are the biguanides side effects? Metformin, Glucophage is diabetes medicines.
https://healthy-ojas.com/diabetes/biguanide.html
Effect of surfactants, temperature, and sonication on the virucidal activity of polyhexamethylene biguanide against the...Effect of surfactants, temperature, and sonication on the virucidal activity of polyhexamethylene biguanide against the...
Background Virucidal compounds are essential in preventing the transmission of viral infection in the health care environment. Understanding their mechanisms of action is necessary to improve their efficacy. Inactivation of viruses is less documented than that of bacteria notably because different types of virus have diverse response to microbicides, making difficult to establish an inactivation pattern. Methods The effect of viral aggregates on the virucidal activity of polyhexamethylene biguanide-based microbicide VANTOCIL™ TG (Arch Chemicals, Manchester, UK) against the bacteriophage MS2 was investigated by using in combination a standard suspension efficacy test under different conditions and dynamic light scattering measuring the presence and size of aggregates. Results Temperature had a key role in increasing significantly the virucidal activity of VANTOCIL™ TG, reducing virus concentration by 4-log10 within 10 minutes at 40°C. The high temperature was linked to a reduction of viral ...
https://orca.cf.ac.uk/6683/
Enzymatic detergent Aniosyme DD1, decontaminating, 1 liter with dispenser - pserviceweb.comEnzymatic detergent Aniosyme DD1, decontaminating, 1 liter with dispenser - pserviceweb.com
Aniosyme DD1 guarantees a high performance cleaning and optimum safety, fits perfectly in a perspective of the properties detergents standardization. Bottle 1 liter, concentrated Efficacy proven product that optimizes cleaning- Pre-disinfection / decontamination broad-spectrum detergent *- Neutral pH *- Detergent pre-disinfectant / decontaminant high performance *- Broad spectrum of efficacy INDICATIONS: Deep cleaning and pre-disinfection / decontamination of medical and surgical instruments, medical devices and endoscopic equipment.Cleaning in ultrasonic tanks.Collection of contaminated instruments.STATEMENT: quaternary ammonium propionate, of polyhexamethylene biguanide hydrochloride, enzymatic complex (protease, lipase and amylase), surfactants, stabilizers, sequestering agent, perfume, dye.PROPERTY MICROBIOLOGICAL: Bactericidal: EN 1040, EN 13727, NF T 72-170, SARM (EN 13727), Active on Mycobacterium tuberculosis (B.K.). Lieviticida: EN 1275 (C. albicans).Active on HIV-1, BVDV (HCV) virus model,
http://www.pserviceweb.com/home/en/disinfection-decontamination-and-conservation/14776-enzymatic-detergent-aniosyme-dd1-decontaminating-1-liter-with-dispenser.html
Patent US6936640 - Biguanide/quaternary ammonium containing copolymeric biocides and use ... - Google PatentsPatent US6936640 - Biguanide/quaternary ammonium containing copolymeric biocides and use ... - Google Patents
Biguanide/quaternary ammonium compounds and the use of same as antimicrobial agents in pharmaceutical compositions are described. The biguanide/quaternary ammonium compounds are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.
http://www.google.co.uk/patents/US6936640
Alogliptin Tablets Special Drug Use Surveillance Type 2 Diabetes Mellitus: Combination Therapy With Biguanides - Tabular View -...Alogliptin Tablets Special Drug Use Surveillance Type 2 Diabetes Mellitus: Combination Therapy With Biguanides - Tabular View -...
This is a special drug use surveillance on long-term use of alogliptin with a 1-year (12-month) observational period, designed to investigate the safety and efficacy of long-term combination therapy with alogliptin and biguanides in participants with type 2 diabetes mellitus in the routine clinical setting.. Participants diagnosed with type 2 diabetes mellitus who responded inadequately to treatment with biguanides in addition to diet therapy and exercise therapy will be enrolled. The planned sample size is 1,000.. The usual adult dosage for oral use is 1 alogliptin tablet (25 mg) once daily. ...
https://clinicaltrials.gov/ct2/show/record/NCT01964976?show_rss=Y&sel_rss=mod14
Poly (hexamethylene biguanide) hydrochloride (CAS 32289-58-0) Market Research Report 2017Poly (hexamethylene biguanide) hydrochloride (CAS 32289-58-0) Market Research Report 2017
The report generally describes poly (hexamethylene biguanide) hydrochloride, examines its uses, production methods, patents. Poly (hexamethylene biguanide)
https://marketpublishers.com/report/industry/chemicals_petrochemicals/poly_hexamethylene_biguanide_hydrochloride_32289-58-0_market_research_report.html
BiguanideBiguanide
Biguanide Biguanides (ATC A10 BA) form a class of oral antihyperglycemic drugs used for diabetes mellitus or prediabetes treatment.
http://www.chemeurope.com/en/encyclopedia/Biguanide.html
Biguanides - Low Carb RN (CDE)
If you have not already done so, please read my introduction page (HERE). . How do biguanides work? Biguanides work by decreasing the output of glucose from the liver. They also activate an enzyme which help cells to become more sensitive (less resistant) to insulin. This is particularly helpful in Type 2 diabetes, although those…
https://lowcarbrn.wordpress.com/diabetes/drugs-to-treat-diabetes/biguanides/
Swimming Pool Biguanide ChemicalsSwimming Pool Bio SanitizerSwimming Pool Biguanide ChemicalsSwimming Pool Bio Sanitizer
Swimming Pool Biguanide Chemicals is a 3 part manual process, it is very, very expensive. Sometimes costing several times more than chlorine. Biguanide needs to be purchased in bulky containers and needs to be manually added to the pool water regularly.
http://gochemless.com/learning-center/swimming-pool-biguanide-chemicals/
Biguanide Reagent for eXact (50 tests) 486810 - SimplexHealthBiguanide Reagent for eXact (50 tests) 486810 - SimplexHealth
Biguanide reagent for our handy water quality tester. Range: 1.6 - 210ppm (mg/l). No of Tests: 50. Please note: Replacement biguanide reagent test strips only for use with eXact Micro 20 photometer.. This product can only be used with one of the above mentioned photometers. Not to be used on a standalone basis.. MPN: 486810. ...
https://www.simplexhealth.co.uk/product/biguanide-reagent-for-exact-50-tests-486810/
Polyhexanide - WikipediaPolyhexanide - Wikipedia
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae). Some products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection. PHMB eye drops have been used as a treatment for eyes ...
https://en.wikipedia.org/wiki/Polyhexanide
Spa Help - Utah Hot Tubs, Swim Spas and Pool Tables | Take A Break Spas and BilliardsSpa Help - Utah Hot Tubs, Swim Spas and Pool Tables | Take A Break Spas and Billiards
What should I know about using Biguanide products? People that want an alternative spa chemical treatment that is non-chlorine/non-bromine system enjoy using biguanide products (i.e. brand names: Soft Soak, Baqua, Leisure Time Free 1-2-3). The active ingredient in biguanide spa chemical systems, polyhexamethylene biqunaide (PHMB), destroys bacterial cells. The destruction allows the cell contents to disperse into their surroundings where they are further broken down into their elemental parts by a non-chlorine oxidizer. Mild coagulants combine the cells and small particles in the environment into particles large enough to be trapped by the filter. If the correct type of filter cleaner is not used the gray film and cleaner will create a non-cleanable gum-like substance and the filter cartridge must be replaced. NOTICE: The use of BIGUANIDE chemicals as sanitizers will void warranty on spa equipment components on many spa models. We offer biguanide product lines as well as Mineral Sanitizers as ...
https://www.takeabreakspas.com/spa-help.html
Effect of poly-hexamethylene biguanide hydrochloride (PHMB) treated non-sterile medical gloves upon the transmission of...Effect of poly-hexamethylene biguanide hydrochloride (PHMB) treated non-sterile medical gloves upon the transmission of...
99.99%) within 10 min of contact-time but only ~2.5log10 (>99.9%) and ~1.0log10 reduction respectively when heavy-soiling or blood was present. Gloves became highly-contaminated (~4.52log10-4.91log10cfu) when handling recently-contaminated computer-keys. Untreated gloves contaminated recipient surfaces (~4.5log10cfu) while PHMB-treated gloves transferred fewer bacteria (2.4-3.6log10cfu). When surface contamination was dry, PHMB gloves transferred fewer bacteria (0.3-0.6log10cfu) to recipient surfaces than untreated gloves (1.0-1.9log10; P < 0.05). Antimicrobial-impregnated gloves may be useful in preventing dissemination of organisms in the near-patient environment during routine care. However they are not a substitute for appropriate hand-hygiene procedures ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2661-9/open-peer-review
Polyhexamethylene guanidine hydrochloride. CAS number: 57029-18-2Polyhexamethylene guanidine hydrochloride. CAS number: 57029-18-2
PHMG hydrochloride or polyhexamethylene guanidine hydrochloride - a cationic polyelectrolyte having a unique combination of physical, chemical and biocidal properties, allowing the polymer applied in virtually all areas of the economy.. Abbreviations: PHMG, PHMGH, PHMG-HC, PHMG hydrochloride, PHMG chloride.. Name PHMG hydrochloride IUPAC classification: poly (imnokarbonimidoilimino-1,6-hexanediyl) hydrochloride. In English: Poly (iminocarbonimidoylimino-1,6-hexanediyl), monohydrochloride.. Synonyms polyhexamethylene guanidine hydrochloride: polyhexene (iminoimidokarboniminogeksametilen) hydrochloride.. CAS number: 57029-18-2.. The name in English and the structural formula polyhexamethylene guanidine hydrochloride: Poly (hexamethyleneguanidine) hydrochloride, (C7H16N3Cl) n, where n = 4-50, molecular weight: 700-10000 amu. Physical and chemical properties PHMG hydrochloride:. ...
http://polyguanidines.ru/en/index.htm
Polyhexamethylene guanidine - WikipediaPolyhexamethylene guanidine - Wikipedia
Polyhexamethylene guanidine (PHMG) is a guanidine derivative that is used as a biocidal disinfectant, often in the form of its salt polyhexamethylene guanidine phosphate (PHMG-P). Studies have shown that PHMG in solution has fungicidal as well as bactericidal activity against both Gram-positive and Gram-negative bacteria. The substance also has detergent, anti-corrosive, and flocculant properties and prevents biofouling. PHMG-P is a white powdered solid, and as all polyguanidine salts, readily soluble in water. Unlike the related polymer polyhexanide (PHMB), PHMG has been described as a relatively new compound with properties, potency, and effects being not yet fully recognized. Preliminary findings indicate that PHMG and its derivatives primarily rely on damaging the cell membrane by inhibiting the activity of cellular dehydrogenases. When PHMG is aerosolized and inhaled, it harms the lungs, causing death of the cells lining the bronchioles and widespread damage to alveoli, along with ...
https://en.wikipedia.org/wiki/Polyhexamethylene_guanidine
Plus itPlus it
There are two broad types of insulin sensitizers: the biguanides and the thiazolidinediones, also called peroxisome proliferator-activated receptor-γ agonists.. The biguanides enhance insulin action, stimulating glucose uptake in the liver and in the periphery and also suppressing hepatic glucose output. They only work when insulin is present, do not stimulate insulin secretion or release, and do not cause hypoglycemia. They are used for patients with type 2 diabetes who have residual β-cell function, typically when diet and exercise are insufficient for diabetic control. They are also useful in the insulin resistance syndrome and constitute an increasingly popular treatment for polycystic ovarian syndrome, often inducing ovulation and resulting in pregnancy. Phenformin was the original biguanide but was removed from the market in the 1960s because of reports of fatal lactic acidosis. Metformin (Glucophage) is the only biguanide currently available in the U.S.. Metformin is a relatively small ...
https://care.diabetesjournals.org/content/30/Supplement_2/S206
GB/T 26367-2020 English Version, GB/T 26367-2020 Hygienic requirements for biguanides disinfectants (English Version) - Code of...GB/T 26367-2020 English Version, GB/T 26367-2020 Hygienic requirements for biguanides disinfectants (English Version) - Code of...
GB/T 26367-2020 English Version - GB/T 26367-2020 Hygienic requirements for biguanides disinfectants (English Version): GB/T 26367-2020, GB 26367-2020, GBT 26367-2020, GB/T26367-2020, GB/T 26367, GB/T26367, GB26367-2020, GB 26367, GB26367, GBT26367-2020, GBT 26367, GBT26367
https://codeofchina.com/standard/GBT26367-2020.html
Patent WO2000035500A1 - Contact lens cleaner comprising biguanide and poloxamine - Google PatentsPatent WO2000035500A1 - Contact lens cleaner comprising biguanide and poloxamine - Google Patents
The present invention is directed to a biguanide-containing disinfecting solution containing a particular type of poloxamine for stabilizing a polymeric biguanide. The poloxamine surfactant comprises at least about 90 weight percent of poly(oxyethylene) and poly(oxypropylene) segments, in one or more copolymer chains, wherein the weight average molecular weight of said surfactant is from about 10,000 to about 30,000 and wherein at least about 70 weight percent of said poly(oxyethylene) and poly(oxypropylene) segments are poly(oxyethylene) segments, and wherein the HLB value is at least 27. The method of the present invention comprises cleaning and disinfecting a contact lens with the above-described solution. Products according to the present invention provide enhanced cleaning while maintaining biocidal efficacy.
http://www.google.co.uk/patents/WO2000035500A1?cl=en
Energy balance at the organism and cellular level: effects of biguanides | Springer for Research & DevelopmentEnergy balance at the organism and cellular level: effects of biguanides | Springer for Research & Development
Metformin, an inhibitor of OXPHOS, is widely used for treatment of type II diabetes (T2D). A key site of action in diabetes treatment is liver, where the drug achieves a relatively high concentration following oral administration, leading to inhibition of gluconeogenesis and reduction of the hyperglycemia and hyperinsulinemia of T2D. As high levels of insulin have been associated with poor prognosis of prostate, breast, and colon cancer and as early retrospective pharmaco-epidemiologic studies suggested reduced cancer burden among diabetics treated with metformin relative to other diabetes treatments, the hypothesis that metformin or other biguanides could be useful in cancer prevention or treatment has received considerable attention. However, it is not clear if metformin at conventional anti-diabetic doses administered to non-diabetic subjects has effects of sufficient magnitude on levels of insulin or other candidate mediators to influence cancer biology. Drugs used for androgen deprivation ...
https://rd.springer.com/article/10.1186/2049-3002-2-S1-O26
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria | Biochemical JournalEffects of metformin and other biguanides on oxidative phosphorylation in mitochondria | Biochemical Journal
Complex I catalyses electron transfer from NADH to hydrophilic electron acceptors by two distinct mechanisms, both localized uniquely at the flavin site. The NADH:FeCN and NADH:O2 reactions proceed via two sequential steps in which NADH reduces the flavin and dissociates, and then the electron acceptor reacts directly (see Figure 2E, left-hand reaction) [26]; for the NADH:HAR and NADH:paraquat reactions NADH reduces the flavin, but the electron acceptor reacts only if a nucleotide is bound in the reduced flavin site (see Figure 2E, right-hand reaction) [27]. Note that although NADH:O2 oxidoreduction produces superoxide, we detect the H2O2 formed following superoxide dismutation, and thus refer to H2O2 production. Data showing the effects of biguanides on these different reactions are shown in Figure 2. Figure 2(A) shows that metformin stimulates the rates of the two reactions (the NADH:FeCN and NADH:O2 reactions) that rely on oxidation of the nucleotide-free reduced flavin [15,26], but, ...
http://www.biochemj.org/content/462/3/475
Biguanides: MetforminBiguanides: Metformin
What is metmorfin (biguanides)? How does metmorfin work? Does metformin have any side effects? Information about this first line therapy for type 2 diabetes.
https://asweetlife.org/diabetes/type-2-diabetes/type-2-diabetes-treatments/biguanides-metformin/
Pioglitazone Tablets Special Drug Use Surveillance Combined Use of Biguanides / Long-term Treatment - Full Text View -...Pioglitazone Tablets Special Drug Use Surveillance Combined Use of Biguanides / Long-term Treatment - Full Text View -...
This is a special drug use surveillance with an observation period of 12 months designed to investigate the safety and efficacy of pioglitazone (Actos) in the routine clinical setting in patients with type 2 diabetes mellitus who responded inadequately to treatment with biguanides in addition to diet therapy and exercise therapy (planned sample size, 1000).. The usual adult dosage is 15 to 30 mg of pioglitazone administered orally once daily before or after breakfast. Dose adjustment will be made according to gender, age, and symptoms with an upper limit of 45 mg. ...
https://www.clinicaltrials.gov/ct2/show/study/NCT02003014?term=237-017&rank=1
Does your micellar solution contain polyaminopropyl biguanide? | ParokeetsDoes your micellar solution contain polyaminopropyl biguanide? | Parokeets
Polyaminopropyl biguanide will soon land on the unsafe lists. Here are some of the micellar solutions with and some without mentioned preservative.
https://www.parokeets.com/en/2015/06/does-your-micellar-solution-contain-polyaminopropyl-biguanide/
25 Count AquaChek Blue Biguanide Pool Water Test Strips For Sale - Pool Supplies & Parts
Finding the perfect Pool Cleaners and Chemicals products can be extremely challenging. Were here to bring you hand picked Pool Cleaners and Chemicals products to purchase on the internet. This page features 25 Count Aquachek Blue Biguanide Pool Water Test Strips in the Pool Cleaners and Chemicals category. Not finding exactly what youre looking for? Take a peek at our other posts in the Pool Cleaners and Chemicals category for more options. Make sure to earmark this site and return soon, as our selection changes frequently.. ...
https://www.poolsuppliesonlinesuperstore.com/pool-cleaners-and-chemicals/25-count-aquachek-blue-biguanide-pool-water-test-strips-for-sale/
Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide...Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide...
Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs. by Chia-Chi Hsu, Ling-Chia Wu, Cheng-Yuan Hsia, Pen-Hui Yin, Chin-Wen Chi, Tien-Shun Yeh, Hsin-Chen Lee. Oncology reports. Read more related scholarly scientific articles and abstracts.
https://www.sigmaaldrich.com/US/en/tech-docs/paper/663907
1-(2,6-diethyl-phenyl)-biguanide | C12H19N5 - PubChem1-(2,6-diethyl-phenyl)-biguanide | C12H19N5 - PubChem
1-(2,6-diethyl-phenyl)-biguanide | C12H19N5 | CID 548295 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/548295
1-(2,4-Xylyl)biguanide | C10H15N5 - PubChem1-(2,4-Xylyl)biguanide | C10H15N5 - PubChem
1-(2,4-Xylyl)biguanide | C10H15N5 | CID 20879 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/20879
BioGuard SOFTSWIM B Chlorine-Free Sanitizer (1/2 Gal) (BIGUANIDE POOLS - Cozy Pools and Spas
This poly-biguanide sanitizes the pool water. By maintaining a B level between 30 and 50 ppm, bacteria are controlled. (BIGUANIDE POOLS ONLY)
https://shopcozypools.com/products/bioguard-softswim-b-chlorine-free-sanitizer-1-2-gal
Winterizing SoftSwim, Baquacil and biguanide treated Pools, Par Pool & Spa
Winterizing SoftSwim, Baquacil and biguanide treated Pools, arctic blue winter kit 24, winter chemical kits, BioGuard Arctic Blue winter kit 12, Arctic blue shock, BioGuard winter algicide, pool winterizing, Swimming pools, inground pool winterizing, aboveground pool winterizing, winterization, chlorine, bromine, Mineral Springs, BioGuard, Pristine Blue, Soft Swim, Aquador, winter plugs, winter covers, pool safety covers, winterizing instructions
http://www.parpool-spa.com/Page/Winterizing/winter_Soft-Swim_Close.html
ChemIDplus - 101491-44-5 - KUXDDCZUGHZCEJ-UHFFFAOYSA-N - Biguanide, 1-octyl-, monohydrochloride - Similar structures search,...ChemIDplus - 101491-44-5 - KUXDDCZUGHZCEJ-UHFFFAOYSA-N - Biguanide, 1-octyl-, monohydrochloride - Similar structures search,...
101491-44-5 - KUXDDCZUGHZCEJ-UHFFFAOYSA-N - Biguanide, 1-octyl-, monohydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/101491-44-5
Antimicrobial Efficacy of New Investigational Multipurpose Disinfecting Solution and Comparison to Commercially Available...Antimicrobial Efficacy of New Investigational Multipurpose Disinfecting Solution and Comparison to Commercially Available...
Purpose: To evaluate antimicrobial efficacy of investigational multipurpose formulation against bacteria, fungi and Acanthamoeba spp. and compare it to commercially available multipurpose disinfecting solutions (MPS). Study was done according to ISO 14729:2001/A.2010 standard.. Methods: The multipurpose disinfecting solutions studied were - Investigational MPS-1: polyhexamethylene biguanide (PHMB) + poloxamer (PLX) and currently marketed Japan products MPS-2: polyquaternium (PQ1) + tetronic 1304, MPS-3: PHMB + poloxamine (PLA) and MPS-4: PHMB +PLX. Test organisms were: Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 9027), Serratia marcescens (ATCC 13880), Candida albicans (ATCC 10231), Fusarium solani (ATCC 36031) and Gram-negative clinical isolates. Test solutions were evaluated at the minimum recommended disinfection time of 4 hours. Disinfectant efficacy of MPS was also evaluated against Acanthamoeba trophozoites.. Results: After 4 hours exposure, Investigational MPS-1 and ...
https://iovs.arvojournals.org/article.aspx?articleid=2150092
Bundle of 6 ) Prontosan Wound Solution 40mL | Poisson PharmaBundle of 6 ) Prontosan Wound Solution 40mL | Poisson Pharma
Price is for 6 ampoules. Each ampoule is 40mL. Prontosan® Wound Solution is a wound cleanser (irrigation solution) for wound decontamination. It contains two key ingredients: Polyhexamethylene biguanide (PHMB), an antimicrobial agent (0.1%) Betaine, a surfactant (0.1%) In Prontosan, the combination of PHMB with a surfactant (betaine) has an increased ability to penetrate difficult-to-remove coatings, lifting debris, bacteria and biofilm from the wound. This is supported by clinical evaluations that have reported increased healing rates and reduced incidence of wound infection. *Biofilms are complex microbial communities living within a three-dimensional extracellular polysaccaride (EPS) matrix embedded in a thick slimy blanket of sugars and proteins. The matrix acts as a barrier, protecting the micro-organisms from cellular and chemical attack. Biofilms delay wound healing. Indication: Cleansing and decontamination of skin wounds and burns Traumatic wounds Postoperative wounds Chronic skin ulcers (e.g.
https://www.poissonpharma.sg/product-page/prontosan-wound-solution-40ml
Arcaine sulfate,N,N-1,4-Butanediylbisguanidinesulfate 14923-17-2 Route Of Synthesis Synthetic RoutesArcaine sulfate,N,N-1,4-Butanediylbisguanidinesulfate 14923-17-2 Route Of Synthesis Synthetic Routes
Arcaine sulfate,N,N-1,4-Butanediylbisguanidinesulfate 14923-17-2 route of synthesis, Arcaine sulfate,N,N-1,4-Butanediylbisguanidinesulfate chemical synthesis methods, Arcaine sulfate,N,N-1,4-Butanediylbisguanidinesulfate synthetic routes ect.
http://www.molbase.com/en/synthesis_14923-17-2-moldata-88259.html
7089 Excilon™ AMD Antimicrobial I.V. Sponge 2 x 2 1400/case [7089] - $261.81 : Balego & Associates Inc. - BalegoOnline.org,...7089 Excilon™ AMD Antimicrobial I.V. Sponge 2 x 2 1400/case [7089] - $261.81 : Balego & Associates Inc. - BalegoOnline.org,...
Balego & Associates Inc. - BalegoOnline.org 7089 Excilon™ AMD Antimicrobial I.V. Sponge 2 x 2 1400/case [7089] - Excilon™ AMD drain sponges are impregnated with PHMB (Polyhexamethylene Biguanide), a powerful yet safe antiseptic that has a broad range effectiveness against gram positive and gram negative microorganisms including some multi-drug resistant strains such as MRSA. This exciting new product provides healthcare facilities a low cost, prophylactic method of treatment
http://www.balegoonline.org/index.php?main_page=product_info&cPath=13_342_347&products_id=1811&zenid=a3nekulg8bjbq2s6lje4ca3561
AMD Wound Dressings - H&R Healthcare
The AMD family provides a clinically, cost effective solution for the treatment of critically colonised wounds. The AMD range includes Kendall™, Telfa™ and Kerlix™, each of which come in a variety of dressing presentations.. They are designed to manage varying levels exudate and contain the highly effective antimicrobial Polyhexamethylene Biguanide (PHMB). This combination of intelligent exudate management and antimicrobial activity supports optimal wound healing environments.. ...
http://hrhealthcare.co.uk/product-sub-category/amd-wound-dressings/
Mahomed, Anisa<...Mahomed, Anisa<...
Campbell, Darren; Mahomed, Anisa; Rasul, Nadia; Broadbent, Marc and Tighe, Brian (2011). Novel tear film supplements:a potential application for synthetic protein-phospholipid complexes. IN: British Contact Lens Association. 2010-05-27 - 2010-05-30. Mann, Aisling; Mahomed, Anisa; Tighe, Brian and Campbell, Darren (2009). Comparative performance of analytical techniques for polyhexamethylene biguanide (PHMB) in ophthalmic solutions. IN: British Contact Lens Association. 2010-05-27 - 2010-05-30. ...
http://publications.aston.ac.uk/view/author/Mahomed=3AAnisa=3A=3A.html
Kendall Company Kerlix Amd Super Sponges - Pack Of 2 - Model 6662
Kendall Company Kerlix AMD Super Sponges - Pack of 2 - Model 6662 : Antimicrobial sponges contain PHMB(Polyhexamethylene Biguanide) which resists bac
http://www.egeneralmedical.com/inv-knd6662-2.html
Baquacil, Biguanides and PHMB - Swimming Pool HelpBaquacil, Biguanides and PHMB - Swimming Pool Help
I have used Baquacil for 8 years. The last 6 weeks of 2006 was terrible, and this year has been worse. Its eating the shock as fast as I can put it in. I have a 24 foot ...
http://www.poolhelpforum.com/viewforum.php?f=61
A - pg193-194
in Belfast and in Edinburgh, and our clinical experiencegradually supported the rather meagre scientific Pharmaceutically, metformin is an interesting substance, background to the drug. (One suggested explanation of and at times those working on it might have diverted into its action was biophysical rather than biochemical - it the antimicrobial actions of the biguanides - germicidal, was a mild cell poison that made holes in the cell antiviral and antimalarial - the most widely used of these membrane and allowed glucose to enter without the compounds is hexamethyl bischlorophenyl biguanide, or need for insulin!) In the south of England it was not chlorhexidine, a useful germicide and disinfectant.1 The widely used, and it was never marketed in the USA at history of the early researchers has been extensively that time. A number of clinical studies by Dr B Clarke reviewed under the auspices of the pharmaceutical firms and Dr L Duncan at the Royal Infirmary of Edinburgh, and Lipha and Merck, who ...
http://findmedarticle.com/r/rcpe.ac.uk1.html
Glucophage 1000mg Tablets - Rosheta
Glucophage 1000mg Tablets About Metformin Biguanide derivative, Oral anti-diabetic. Mechanism of Action of Metformin It is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics. Indications for Metformin Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise). Typical Dosage for Metformin Adults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily. Children: Not applicable.
https://www.rosheta.com/en/1061/glucophage
Pan-Antimicrobial Failure of Alexidine as a Contact Lens Disinfectant by B. Laurel Elder, John D. Bullock et al.Pan-Antimicrobial Failure of Alexidine as a Contact Lens Disinfectant by B. Laurel Elder, John D. Bullock et al.
Objective: ReNu with MoistureLoc (ReNuML), containing the antimicrobial agent alexidine 0.00045%, was associated with the Fusarium keratitis epidemic of 2004 to 2006. Although a single-point source contamination was ruled out, only Fusarium organisms were reported during the outbreak. This study investigated whether the reported loss of antimicrobial effectiveness toward Fusarium of ReNuML after exposure to heat in high-density polyethylene (HDPE) plastic containers could also be demonstrated with other common fungal and bacterial agents of keratitis. Methods: A buffered solution of alexidine 0.00045% was incubated in glass and ReNu HDPE plastic containers at room temperature (RT) and 56°C for 4 weeks, serially diluted, and tested for its ability to inhibit the growth of 20 bacterial isolates, 12 non-Fusarium fungal isolates, and 7 Fusarium isolates originally involved in the keratitis epidemic. Results: A statistically significant loss of antimicrobial capability was seen with all fungi, all gram
https://corescholar.libraries.wright.edu/math/274/
Perception and acceptance of the use of 0.2% polyhexanide versus 0.12% chlorhexidine digluconate in patients at a risk of...Perception and acceptance of the use of 0.2% polyhexanide versus 0.12% chlorhexidine digluconate in patients at a risk of...
Objective: To evaluate the perception and acceptance of using polyhexanide (PHMB) and chlorhexidine digluconate (CLX) in individuals at a risk of developing oral mucositis induced by chemoradiotherapy. Materials and Methods: This is a randomised comparative study. Participants were randomised into two groups: Group 1 (PHMB 0.2%) and Group 2 (CLX 0.12%), these groups performed a mouth rinse with the respective solutions for 1 minute every 12 hours during an antineoplastic treatment cycle. The participants were evaluated at three different times: before (t0), during (t1) and after a cycle of antineoplastic treatment (t2). Severity of oral mucositis (OM), mouth pain, quality of life (OHIP-14), oral hygiene index and assessment of the acceptance of the substances in the mouth were assessed. Results: There were 23 individuals, 12 in Group 1 (G1) and 11 in Group 2 (G2). Both groups presented with OM in all three evaluations. Reported mouth pain was lower in G1 than in G2. The PHMB had a better ...
http://joralres.com/index.php/JOR/article/view/joralres.2020.035
Contact Lens Spectrum - March 25, 2012Contact Lens Spectrum - March 25, 2012
Multipurpose contact lens solution (MPS)/preservative-associated transient corneal hyperfluorescence has been suggested to represent corneal injury. To determine the validity of this assumption, the molecular-level interactions of common disinfectants in soft contact lens MPS and the corneal epithelium using an in vitro model were assessed.. A liposome-based model of the corneal epithelial surface was developed and used to assess the interactions of polyhexamethylene biguanide (PHMB), polyquaternium-1 (PQ-1), and fluorescein with membrane components and the effects of PHMB and PQ-1 on membrane integrity. The fluorescence anisotropy (a measure of interactions between molecules) was determined. Liposome integrity was assessed by measuring the liposome melting point temperature.. Free fluorescein did not associate with the liposome (P , 0.4). Both fluorescein-tagged PHMB and PQ-1 associated with liposomes (P , 0.002 and P ,/= 0.01, respectively); however, only PHMB induced free fluorescein ...
https://www.clspectrum.com/newsletters/contact-lenses-today/march-25,-2012
Survival and Distribution of Fusarium and Acanthamoeba in Drying MPS | IOVS | ARVO JournalsSurvival and Distribution of Fusarium and Acanthamoeba in Drying MPS | IOVS | ARVO Journals
Purpose: : To examine further the association between the recent outbreaks of microbial keratitis caused by unusual organisms and the contamination of multipurpose contact lens disinfection solutions (MPS) during use. Methods: : Conidia of representative isolates of the Fuarium solani-F. oxysporum complexes and trophozoites of Acanthamoeba castelanii were inoculated (~104 ml-1) into 1-2 ml of MPS that contained either polyhexamethylene biguanide (PHMB) or polyquaternium-1 (PQ) as active disinfecting components. Phosphate-buffered saline (PBS) served as a control. These preparations were examined microscopically during drying under a laminar flow hood at ambient temperatures. Results: : The various MPS formed distinct and characteristic concentric bands of precipitates and viscous globules while drying. The distribution of the conidia, trophozoites and amoebic cysts among the distinctive residual- precipitate patterns varied for the different MPS. Cysts were not evident in the initial trophozoite ...
https://iovs.arvojournals.org/article.aspx?articleid=2380902
A solution for contact lens germicide | Clear Vision Eyecare in Daly City
One common, very popular germicide that most people will have come across but will not have heard of is polyhexamethylene biguanide, abbreviated for ease to PHMB. It is applied to the water in swimming pools, industrial processes, personal care products, cosmetics, fabric softeners, hand washes, wound dressings and contact lens solutions. It is also applied…
https://clearvisioneyecare.wordpress.com/2010/01/05/a-solution-for-contact-lens-germicide-a-solution-for-contact-lens-germicide/
Plus itPlus it
Metformin is the sole member of the biguanide class of medications in the United States. It replaced another biguanide, fenformin, which was removed from the market because of a propensity for lactic acidosis in 1975.3,4 Available in short-acting and sustained-release formulations, it is one of the oldest, and indeed one of the safest, medications used in the treatment of type 2 diabetes.. Metformin exerts its effects primarily by decreasing hepatic glucose output and has a comparatively lesser effect increasing insulin sensitivity. Isotope studies suggest hepatic glucose output is reduced primarily through inhibition of gluconeogenesis, which may be reduced by as much as 75%.4 Patients using metformin also exhibit lower fasting insulin concentrations. Most patients using metformin lose weight, and as much as 88% of weight loss with metformin is loss of body fat mass. In patients with normal renal function and who are otherwise healthy, metformin does not increase plasma lactic acid levels or ...
http://clinical.diabetesjournals.org/content/25/4/131
theblackcedar.com
Pharmacotherapeutic group: Blood Glucose lowering drugs, excl Insulins, Biguanides Metformin hydrochloride is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycaemia. Metformin hydrochloride may act via 3 mechanisms: (1) reduction of hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis (2) in muscle, by increasing insulin sensitivity, improving peripheral glucose uptake and utilization (3) and delay of intestinal glucose absorption. Metformin hydrochloride stimulates intracellular glycogen synthesis by acting on glycogen synthase. Metformin hydrochloride increases the transport capacity of all types of membrane glucose transporters (GLUTs) known to date. In humans, independently of its action on glycaemia, metformin hydrochloride has favourable effects on lipid metabolism. This has been shown at therapeutic doses in controlled, medium-term or ...
http://pdfmedarticles.com/t/theblackcedar.com1.html
An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer - Center for Genomic MedicineAn Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer - Center for Genomic Medicine
Cell. 2016 Dec; 167(7), p1705-1718.e13.. Metformin has utility in cancer prevention and treatment, though the mechanisms for these effects remain elusive. Through genetic screening in C. elegans , we uncover two metformin response elements: the nuclear pore complex (NPC) and acyl-CoA dehydrogenase family member-10 (ACAD10). We demonstrate that biguanides inhibit growth by inhibiting mitochondrial respiratory capacity, which restrains transit of the RagA-RagC GTPase heterodimer through the NPC. Nuclear exclusion renders RagC incapable of gaining the GDP-bound state necessary to stimulate mTORC1. Biguanideinduced inactivation of mTORC1 subsequently inhibits growth through transcriptional induction of ACAD10. This ancient metformin response pathway is conserved from worms to humans. Both restricted nuclear pore transit and upregulation of ACAD10 are required for biguanides to reduce viability in melanoma and pancreatic cancer cells, and to extend C. elegans lifespan. This pathway provides a unified ...
https://cgm.massgeneral.org/publications/ancient-unified-mechanism-metformin-growth-inhibition-c-elegans-cancer/
Uncontrolled hyperglycemia Obesity IFG Diabetes 350 - - ppt scaricareUncontrolled hyperglycemia Obesity IFG Diabetes 350 - - ppt scaricare
A Century of Diabetes Care Pump therapy Human insulin Insulin analogs First human treated NPH insulin Type Insulin therapy 1920 Type Diet Sulfonylureas Alpha-glucosidase Inhibitors Biguanide Glitazones Meglitinides Insulin therapy Type 1 Since the early 1920s the only therapy available for type 1 diabetes has been insulin. (Banting and Best discovered insulin 1921) Improvements in insulin delivery have included pump therapy (mid-1970s), transition from animal to human insulin (1980s)1979 and the introduction of rapid acting insulin analogs (1990s) Type 2 Altlhough insulin has been available for type 2 diabetes patients since the 1920s, the major development has been the introduction of a number of oral agents: Sulfonylureas, the first available oral hypoglycemic agents (1956) Metformin (biguanides), although available in Europe for many years, recently available in this country since 1995 Alpha glucosidase inhibitors (starch blockers), thiazolidinediones (glitazones) and megltinides, agents
http://slideplayer.it/slide/188743/
Amophage 500mg Tablets - Rosheta Saudi Arabia
دواء Amophage 500mg Tablets About Metformin Biguanide derivative, Oral anti-diabetic. Mechanism of Action of Metformin It is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics. Indications for Metformin Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise). Typical Dosage for Metformin Adults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily. Children: Not applicable.
https://sa.rosheta.com/en/1052/amophage
Insulin Resistance - What It Is and What to Do About It | Diabetes Health PageInsulin Resistance - What It Is and What to Do About It | Diabetes Health Page
The treatment of hyperglycemia is more than evident. Right now we know of two pharmaceutical methods to showcase hypoglycemic effects:. 1. Engaging in the production of glucose - Metformin, also known as the main medication used in this category. It stops the production of glucose from the muscles and liver.. 2. Increase the insulin intake and produce. This can be done with injection/inhalation, as well as using compounds that trigger and stimulate the produce or insulin secretion. Glipizide or glyburide and sulfonylureas are the main meds that trigger the production of insulin.. The insulins duty is to keep glucose inside the storage disposals of our bodies like the liver, muscles, and adipose.. This newcomer method that reduces glucose levels stimulates therapeutic glucosuria. These sodium inhibitors are considerations for type II diabetes and are very rarely used, mostly because of unforeseen problems.. Metformin and biguanides remain first in line for treatment, however. Biguanides dont ...
https://diabeteshealthpage.com/insulin-resistance/
Conference overview: Targeting Mitochondrial Dysfunction & ToxicityConference overview: Targeting Mitochondrial Dysfunction & Toxicity
Along the same lines, data were presented on biguanides, a class of molecules which include the widely-used diabetes drug metformin. Metformin is known to affect mitochondrial function, and to partially inhibit complex I of the electron transport chain. Interestingly, there is pharmacoepidemiologic data that metformin (and biguanides in general) have antineoplastic activity. Part of this anti-cancer activity may be due to activity involving AMPK and mitochondrial stress, although more work is needed to clarify these observations.. As mentioned above, the role of mitochondrial dysfunction in multiple diseases, as well as a need for agents to meet this need, is becoming increasingly apparent. This not only includes the more common chronic conditions, such as heart failure, diabetes and neurological disease, but also the rare, just as much, if not more so debilitating, genetic mitochondrial diseases.. At present, there is little available to remedy these conditions. Available agents include ...
https://pharmaphorum.com/views-and-analysis/conference-overview-targeting-mitochondrial-dysfunction-toxicity/
S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication...S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication...
The reportedly broad expression of CD85j across different immune cell types suggests an importance for this molecule in the human immune system. Previous reports have shown that this receptor interacts with several HLA class-I molecules, as well as with some viral proteins. We have demonstrated that the subset of CD85j + Natural Killer (NK) cells efficiently controls human immunodeficiency virus type 1 (HIV-1) replication in monocyte-derived dendritic cells (MDDC) in vitro and this led us to hypothesize that the CD85j + NK cell-mediated anti-HIV activity in MDDC is specifically dependent on the interaction between the CD85j receptor and unknown non-HLA class-I ligand(s). In this study, we focused our efforts on the identification of these non-described ligands for CD85j. We found that the CD85j receptor interacts with a calcium-binding proteins of the S100 family; namely, S100A9. We further demonstrated that HIV-1 infection of MDDC induces a modulation of S100A9 expression on surface of the MDDC, which
https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-10-122
Welcome to Varsha Group - Poultry ProductsWelcome to Varsha Group - Poultry Products
New generation biocide that has ant-bacterial, anti-fungal, anti- viral and sporicidal activity at low concentrations. The dodecylamine sulphamate salt in combination with alkyl or aryl-alkyl modified amine salt compound and the biguanide PHMB enter into a molecular structure resulting in a stable biocidal complex. Alkyl didecyl dimethyl ammonium chloride, a powerful long chain quaternary compounds (QAC). It is well known that the long chain QAC possess the greatest anti-bacterial activity.. ...
http://varshagroup.com/medisol.php
Diabetes drug could hold promise for lung cancer patients - Salk Institute for Biological StudiesDiabetes drug could hold promise for lung cancer patients - Salk Institute for Biological Studies
The driving idea behind the research is knowing that AMPK serves as a sensor for low energy loss in cells and that LKB1-deficient cells lack the ability to activate AMPK and sense energy loss, says David Shackelford, a postdoctoral researcher at Salk who spearheaded the study in Shaws lab and is now an assistant professor at UCLAs David Geffen School of Medicine.. That led Shaw and his team to a class of drugs called biguanides, which lower cellular energy levels by attacking the power stations of the cell, called mitochondria. Metformin and phenformin both inhibit mitochondria; however, phenformin is nearly 50 times as potent as metformin. In the study, the researchers tested phenformin as a chemotherapy agent in genetically-engineered mice lacking LKB1 and which had advanced stage lung tumors. After three weeks of treatment, Shaw and his team saw a modest reduction in tumor burden in the mice.. Continuing the study between Salk and UCLA, Shaw and Shackelford coordinated teams in both ...
https://www.salk.edu/news-release/diabetes-drug-could-hold-promise-for-lung-cancer-patients/
Phenformin | CTDPhenformin | CTD
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290 ...
http://ctdbase.org/detail.go?type=chem&acc=D010629
Phenylalaninylargininylarginine: a novel tripeptide exerting Zn2+-dependent, insulin-mimetic inhibitory action on myocardial...Phenylalaninylargininylarginine: a novel tripeptide exerting Zn2+-dependent, insulin-mimetic inhibitory action on myocardial...
A novel tripeptide, Phe-Arg-Arg, was found to exert a potent, insulin-mimetic inhibitory action on lysosomal proteolysis in the Langendorff-perfused rat heart. This tripeptide was synthesized based upon its partial structural analogy to the biguanide anti-hyperglycaemic agent, phenformin (phenylethylbiguanide), which has previously been found to exert a Zn(2+)-dependent inhibitory action on lysosomal proteolysis. Hearts were biosynthetically labelled with [3H]leucine in vitro. The percentage change in subsequent release of [3H]leucine (2 mM non-radioactive leucine) was determined in non-recirculating perfusate. The background Zn2+ content of the perfusate was determined to be 20 nM. Major endogenous Zn2+ buffers were present in molar excess of Zn2+: 0.1 mM citrate, 0.2% BSA, and complete physiological amino acids. Infusion of maximally effective levels of chloroquine (30 microM) or insulin (5 nM) caused a 38% inhibition of total proteolysis, which corresponds to the lysosomal subcomponent. In ...
http://www.biochemj.org/content/293/3/801
MetforminMetformin
Metformin is one of the most commonly used drugs in the world and has earned its place as the first medication to prescribe for type 2 diabetes and those with type 1 who have insulin resistance. It is effective, inexpensive and has limited side effects. You can read more about why in this 2013 study. Metformin is in a class of drugs called biguanides. It significantly lowers blood sugar for most people. Studied in human since the 1950s, it has a very strong track record of safety and improved outcomes. Side effects tend to be minimal and temporary, though there is a minority of people who do not tolerate it well. It does not cause weight gain or low blood sugars. In This Section1 Brand Names for Metformin2 Brand Names for Metformin in Combination with Other Drugs3 How Does Metformin Work?4 Precautions Before Taking Metformin5 Side Effects of Metformin6 How to Take
https://www.diabetesdaily.com/learn-about-diabetes/overview-of-diabetes-drugs/metformin/
Metformin 500 : Tamoxifen 20 mg haarausfall
Metformin, marketed under the tradename Glucophage among others, is the first-line medication for the treatment of type 2 diabetes.Vs. xr c 474 metformin hcl old project khasiat metformin 500mg effect of on insulin levels.Metformin is the generic name of the prescription medications Glucophage, Glumetza, and Fortamet, used to control blood sugar in people with type 2 diabetes.Glucophage is a sugar lowering drug taken orally, whose active ingredient is metformin ( biguanide ).Metformin is a prescription oral drug intended for the treatment of non-insulin-dependent diabetes.Diabetes is a very severe disease and it has many types like.. ...
http://mutinous.tk/cali/metformin-500-dipo.php
Metformin may hold anti-aging promise to increase health spanMetformin may hold anti-aging promise to increase health span
The biguanide metformin, an effective first-line agent for the treatment of type 2 diabetes, has come a long way from the days when the FDA hesitated to approve the drug due to risk for lactic acidosis. Today, metformin, now an inexpensive generic and widely available, has garnered a new reputation as a possible anti-aging wonder pill that influences a host of metabolic and cellular processes
https://www.healio.com/news/endocrinology/20190829/metformin-may-hold-antiaging-promise-to-increase-health-span
Pharmacotherapy of Diabetes in the ElderlyPharmacotherapy of Diabetes in the Elderly
The biguanide metformin lowers glucose by reducing hepatic gluconeogenesis. Metformin also decreases intestinal glucose absorption and enhances sensitivity to insulin.7,10 Similarly to sulfonylureas, metformin monotherapy reduces the A1C by 1% to 2%.9 In overweight patients with type 2 diabetes, metformin therapy has been associated with a decrease in diabetes-related end points (e.g., death from hyperglycemia, fatal or nonfatal myocardial infarction, renal failure) and all-cause mortality as compared to therapy with insulin or sulfonylureas.14 Metformin, along with lifestyle intervention, is currently recommended as initial therapy for the management of type 2 diabetes.9 Although controlled trials have not studied sufficient numbers of older patients with diabetes, clinical use suggests that metformin is an effective agent in this population.. The most common adverse effects of metformin are gastrointestinal discomfort and diarrhea, which can be minimized by slow titration of the dose and ...
https://www.uspharmacist.com/article/pharmacotherapy-of-diabetes-in-the-elderly
medications for type2 diabetes mellitus - Advice on Diabetesmedications for type2 diabetes mellitus - Advice on Diabetes
Blood glucose level is high in people with diabetes. As glucose remains in the blood rather than entering cells, where it belongs, high blood glucose condition takes place. Insulin must be present and the cell must be hungry for glucose to enable glucose to pass into a cell. The two problems which are faced by people with type 2 diabetes are they do not make reasonably adequate insulin and cells of their bodies do not appear to capture glucose as eagerly as they should. In the United States five classes of drugs are sold viz. Meglitinides, biguanides, sulfonylureas, alpha-glucosidase inhibitors.and thiazolidinediones. To lower blood glucose levels these five classes of drugs act in different ways. Meglitinides are drugs that arouse the beta cells to discharge insulin. Repaglinide and nateglinide are meglitinides. They are taken before meals as hypoglycemia (low blood glucose levels) is a possibility since insulin is liberated due to sulfonylureas and meglitinides.. Alcohol and diabetes ...
https://adviceondiabetes.com/diabetes/diabetes-medication/medications-for-type2-diabetes-mellitus/
Plus itPlus it
Background: Metformin is a biguanide, belonging to the oral hypoglycemic agents and is a widely used in the treatment of type 2 diabetes. Evidence indicate that Metformin inhibits cell proliferation in several human cancers and inhibits the Warburg phenomenon in tumor cells.. Objective: The present study aims to explore the effects of Metformin in hypoxic conditions. Specifically, we focused on pyruvate dehydrogenase (PDH), (hypoxia-inducible factor 1α) HIF-1α levels and the oral squamous cell carcinoma (OSCC) cell phenotype. Additionally, we also investigated a theoretical consequence of Metformin treatment.. Methods: PDH levels in patients with OSCC and oral dysplasia were evaluated. Metformin was administered in vitro to test the effect of Metformin under hypoxic conditions. The results were complemented by Bioinformatics analyses.. Results: Low PDH levels were observed in OSCC, and Metformin promotes an increase in PDH levels in hypoxic conditions. Metformin also reduced HIF-1α mRNA and ...
http://cancerres.aacrjournals.org/content/77/13_Supplement/5424
BUY Glycomet PRICE (Metformin) ONLINE DISCOUNT ORDER CHEAP FOR SALE NO PRESCRIPTION GET
BUY Glycomet PRICE (Metformin) ONLINE DISCOUNT ORDER CHEAP FOR SALE NO PRESCRIPTION GET Metformin is an oral antidiabetic medication that belongs to the biguanide class and used in the treatment of type 2 diabetes.
http://buynowget.us.com/cheap-glycomet-en.html
Aging | Metformin in obesity, cancer and aging: addressing controversies - Full Text
Full Text - Metformin, an oral anti-diabetic drug, is being considered increasingly for treatment and prevention of cancer, obesity as well as for the extension of healthy lifespan. Gradually accumulating discrepancies about its effect on cancer and obesity can be explained by the shortage of randomized clinical trials, differences between control groups (reference points), gender- and age-associated effects and pharmacogenetic factors. Studies of the potential antiaging effects of antidiabetic biguanides, such as metformin, are still experimental for obvious reasons and their results are currently ambiguous. Here we discuss whether the discrepancies in different studies are merely methodological or inherently related to individual differences in responsiveness to the drug.
https://www.aging-us.com/article/100455/text
Generic Glucophage
Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your bodys response to insulin, a natural substance that controls the amount of glucose in the blood. Metformin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, ...
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Type 2 DiabetesType 2 Diabetes
NT1195 is a novel biguanide designed to improve upon the properties of metformin, particularly for T2D patients with impaired renal function (where metformin has a blackbox warning). NT1195 activates AMPK in metabolic target tissues (see panel opposite) and is 10 - 60x more potent than metformin, especially in cells that have high OCT3 expression (human skeletal muscle and adipocytes).. Detailed PK studies in mice show that NT1195 has a 28.5h half-life (metformin = 1.97h), high levels of exposure (6x ,metformin) and renal clearance that is 50x less than metformin. This latter observation is central to the predicted safety of NT1195 in patients with impaired renal function, since we anticipate that levels of NT1195 will not be raised in patients with kidney disease.. ...
https://www.novatarg.org/programs/type-2-diabetes
Review: Mixed signals from trials concerning pharmacologic prevention of type 2 diabetes mellitus | Annals of Internal Medicine...Review: Mixed signals from trials concerning pharmacologic prevention of type 2 diabetes mellitus | Annals of Internal Medicine...
Randomized controlled trials (RCTs) and cohort studies that provided sufficient data to calculate the incidence of type 2 diabetes using an intention-to-treat analysis, included patients , 18 years of age with a minimum sample size of 50 patients, and compared oral hypoglycemic agents (including biguanides, acarbose, sulfonylureas, and thiazolidinediones), antiobesity agents, antihypertensive drugs, statins, fibrates, or estrogen with placebo. Studies were excluded if they tested an intervention in patients with preexisting diabetes, were duplicates, or were in abstract form. 2 reviewers independently assessed studies for inclusion ...
http://annals.org/aim/article-abstract/2539055/review-mixed-signals-from-trials-concerning-pharmacologic-prevention-type-2
Glucophage Sicherheitsmerkmale Old Buy Uk | Kerala State Poultry Development Corporation
Metformin causes different effects for the mechanism of glucose, which results in improving insulin sensitivity in various tissues like liver and muscles. There a wide range of reasons until this is happening, junk food has never been more available than today and at such affordable prices too. It truly can also be the life-style of a person that plays a role in this incidence. Diabetes may be managed not merely with appropriate diet, and also the operations of medicines. Biguanides - Glucophage (XR) or generic, Metformin. Along achievable, he prescribed 100 milligrams of spironolact (generic kind of Aldactone) twice each day. Although there is a trend indicating improved pathological complete response inside diabetic womens Metformin group, there was clearly no statistically significant difference between your diabetic women taking Metformin and the nondiabetic women. This just isnt dissimilar to conservative obstetrician-gynecologists refusing to continue prescribing metformin for expectant ...
http://kepco.co.in/?q=node/1332
Billiga Apotek På Nätet - Inköp Generisk Metformin 850 mg - Недвижимость в Польше
Om att få Metformin Medicin. Generisk Glucophage ar en biguanide antidiabetic. Generisk Glucophage anvands for behandla typ 2 diabetes. Det fungerar genom att minska mangden socker att levern producerar och tarmarna absorbera. ...
http://tatianaestate.com/billiga-apotek-pa-natet-inkop-generisk-metformin-850-mg/
Type 2 Diabetes - Using Your Diabetes Medications Safely and Effectively » Rosiglitazone
3. Biguanides - metformin (Glucophage, Glucophage XR, Fortamet) limit how much glucose your liver produces. Metformin puts a clamp on your liver and prevents it from dumping out too much sugar. Metformin has become the drug of choice for people with Type 2 diabetes since its introduction in 1994.. 4. DPP-4 Inhibitors or Insulin Extenders help lower blood sugar levels by extending the action of insulin. They include Januvia, Onglyza, Tradjenta, and Nesina.. 5. Sulfonylureas, which include Glucotrol, Glucotrol XL, Micronase, Glynase, Diabeta, and Amaryl, stimulate the cells of your pancreas to produce more of its own natural insulin.. 6. Meglitinides blunt the normal spike in blood sugar that occurs after eating. They enter and leave your body quickly. They are taken 5 to 30 minutes before eating, and stop working within hours. Medications include repaglinide (Prandin) and nateglinide (Starlix).. 7. SGLT2 Inhibitors include canagliflozin (Invokana) and dapagliflozin (Farxiga). They help your ...
http://medicinegrandrounds.info/type-2-diabetes-using-your-diabetes-medications-safely-and-effectively.html
Kidney Disease Treatment www.kidney-support.org: How to Avoid Side Effects Caused by Hypoglycemic DrugsKidney Disease Treatment www.kidney-support.org: How to Avoid Side Effects Caused by Hypoglycemic Drugs
Professionals recommend that, most of hypoglycemic drugs may have a harmful effect on the body. Sulfonylurea and glinides can cause liver damage. Biguanides also lead to gastrointestinal reaction and lactic acidosis, or anaphylaxis and large cell anemia reaction for the little users. As to alpha glucosidase inhibitor, the main side effect is causing gastrointestinal reaction, and which may cause abdominal distension, stomachache, diarrhea and intestinal exhaust too much. Besides, it is reported that the drugs might lead to severe hepatic lesion. Insulin sensitizer can not only trigger liver damage３but also increase the blood volume and the burden of heart ...
http://kidneytreatmentcn.blogspot.com/2012/08/how-to-avoid-side-effects-caused-by.html
Treating Increased A1CTreating Increased A1C
A 64-year-old female presents to your office for her 3-month follow-up. She has previously been diagnosed with mild diastolic heart failure, secondary to hypertension. She currently takes an ace-inhibitor and a diuretic with good control of her heart failure symptoms and hypertension. At her last visit, she had a FPG 118 mg/dl. In a subsequent conversation with her, you discussed how she has developed prediabetes and suggested lifestyle modifications. Since her last visit, she has taken up very gentle walking four times/week and has changed her diet to a more healthful one. Despite these positive changes, this visits labs return an A1C 7.8%; her remaining labs are within normal limits. Which one of the following antihyperglycemic medication classes would you choose to initiate treatment? A. Sulfonylureas B. Biguanides C. Insulin D. Thiazolidinediones Follow the link for the answer.
http://www.diabetesincontrol.com/treating-increased-a1c/
METOVIB SR 1000 Archives - Vibcare PharmaMETOVIB SR 1000 Archives - Vibcare Pharma
Metformin SRMETOVIB SR Send Enquiry Notice: JavaScript is required for this content. Close COMPOSITION Metformin 1000MG/500MG SPECIFICATION FORM TABLET PACKING 10X10 PACKING TYPE BLISTER MRP 370 /193 DESCRIPTIONSIDE EFFECTSINDICATION DESCRIPTION Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption… ...
https://vibcare.co.in/tag/metovib-sr-1000/
Additionally, They Are Innervated By Parasympathetic And Sympathetic Neurons, And Nervous Signals Clearly Modulate Secretion Of...Additionally, They Are Innervated By Parasympathetic And Sympathetic Neurons, And Nervous Signals Clearly Modulate Secretion Of...
I now know that my mum drove home, went into the house and screamed in the and method of prevention and finally the importance of general and specific measures to minimize in the best possible way diabetic complications and maintenance of good heath overall. Osmotic diuresis induced by glucose results in polyurea and subsequent polydipsia ; - polidipsia as more water is excreted, the body requires more water chronic diabetes complications ? Influence on the immune reactivity. The normal coffee plant can grow to a small tree 3 meters , but the usage of the terms Type 1 and Type 2 diabetes instead. commonly used biguanides ? Metformin dianormet once in their lives and approximately 3 % experience frequent and sever episodes. Please visit your physician for diagnosis and treatment your whole day would in fact be spent on wellness, for you. The rise in gestational diabetes has been linked to women having babies siofor Metforgamma, Metfodar Glucophage Forte, Metformin 0.. Glycogen breakdown is ...
http://alexandermiex.soup.io/post/416007172/Additionally-They-Are-Innervated-By-Parasympathetic-And
Equipe 1
2015. Larribere L, Wu H, Novak D, Galach M, Bernhardt M, Orouji E, Weina K, Knappe N, Sachpekidis C, Umansky L, Beckhove P, Umansky V, De Schepper S, Kaufmann D, Ballotti R, Bertolotto C, Utikal J. NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model. Pigment Cell Melanoma Res. 2015 Mar 30. 2014. Lehraiki A, Abbe P, Cerezo M, Rouaud F, Regazzetti C, Chignon-Sicard B, Passeron T, Bertolotto C, Ballotti R, Rocchi S. Inhibition of Melanogenesis by the Antidiabetic Metformin. J Invest Dermatol. 2014 Apr 22. Ohanna M, Bonet C, Bille K, Allegra M, Davidson I, Bahadoran P, Lacour JP, Ballotti R, Bertolotto C. SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells. Oncotarget. 2014 Feb 19. Cerezo M, Tomic T, Ballotti R, Rocchi S. Is it time to test biguanide metformin in the treatment of melanoma? Pigment Cell Melanoma Res. 2014 May 24. Cheli Y, Bonnazi VF, Jacquel A, Allegra M, De Donatis GM, Bahadoran P, Bertolotto C, ...
http://www.unice.fr/c3m/EN/Equipe1.html
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I now know that my mum drove home, went into the house and screamed in the and method of prevention and finally the importance of general and specific measures to minimize in the best possible way diabetic complications and maintenance of good heath overall. Osmotic diuresis induced by glucose results in polyurea and subsequent polydipsia ; - polidipsia as more water is excreted, the body requires more water chronic diabetes complications ? Influence on the immune reactivity. The normal coffee plant can grow to a small tree 3 meters , but the usage of the terms Type 1 and Type 2 diabetes instead. commonly used biguanides ? Metformin dianormet once in their lives and approximately 3 % experience frequent and sever episodes. Please visit your physician for diagnosis and treatment your whole day would in fact be spent on wellness, for you. The rise in gestational diabetes has been linked to women having babies siofor Metforgamma, Metfodar Glucophage Forte, Metformin 0.. Glycogen breakdown is ...
http://alexandermiex.soup.io/since/410884038?mode=own&newer=1
DNA LigasesDNA Ligases
Aims/Introduction:? To judge the basic safety and efficiency from the glucagon‐like peptide‐1 receptor agonist exenatide in Japan sufferers with type?2 diabetes mellitus suboptimally controlled despite therapeutic dosages of the sulfonylurea alone or SU 11654 coupled with a biguanide or thiazolidinedione. (placebo) ?0.39?±?0.28 (exenatide 5?μg) and ?1.54?±?0.27 (exenatide 10?μg; placebo). Nausea mild to average was reported … Continue reading Aims/Introduction:? To judge the basic safety and efficiency from the glucagon‐like. ...
http://www.researchdataservice.com/category/dna-ligases/
Nurse Nacole ◂ Nursing Resources: Nursing Tip of the Day! - FundamentalsNurse Nacole ◂ Nursing Resources: Nursing Tip of the Day! - Fundamentals
Metabolic acidosis is a concern with biguanides. Metformin should be withheld for 48 hours prior to the administration of iodinated contrast media. Afterward, it is advisable to check the serum creatinine level before resuming this medication. ...
http://www.nursenacole.com/2019/11/nursing-tip-of-day-fundamentals_3.html
Glimiprime M 1 Tablet strip of 10 tablets UPTO 30% Offer - mednear.com
Buy Glimiprime M 1 Tablet, packing:strip of 10 tablets, manufacturer : Primus Pharmaceuticals, Glimiprime M 1 Tablet is an anti-diabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Glimiprime M 1 Tablet is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying sugar (glucose) absorption from intestines and increasing the bodys sensitivity to insulin.
https://mednear.com/drugs/Glimiprime-M-1-Tablet-5961d59ab0e6dfb808004849?u=
Type 2 Diabetes | Current Treatment | Detailed, Expanded Analysis: Physician Insights (US) | Research & reports | DRGType 2 Diabetes | Current Treatment | Detailed, Expanded Analysis: Physician Insights (US) | Research & reports | DRG
The highly genericized biguanides and sulfonylureas are, by far, the most heavily prescribed type 2 diabetes (T2D) drug classes. However, branded agents from...
https://decisionresourcesgroup.com/report/716652-biopharma-type-2-diabetes-current-treatment-detailed/
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Nowy smak Coca-Coli na polskich półkach - Prawy.plNowy smak Coca-Coli na polskich półkach - Prawy.pl
Z racji zbliżających się wielkimi krokami Świąt Bożego Narodzenia, amerykański koncern wprowadził na rynek nowy smak Coca-Coli Zero. Będzie on dostępny również w polskich sklepach. Mowa o napoju w odsłonie cynamonowej.. Jak poinformował wprost.pl, nowy smak Coca-Coli można znaleźć już od 3 października w Wielkiej Brytanii. Zarządzający marketingiem koncernu na obszarze tego kraju Alec Mellor określił nową wersję Coca-Coli jako „napój pełen świątecznych smaków, bez cukru, idealny na święta Bożego Narodzenia. - Mamy nadzieję, że nasi aktualni fani i ci, którzy chcą spróbować nowego smaku, pokochają go - mówił.. Wiadomo, że cynamonowa wersja tego produktu pozytywnie zaskoczyła klientów. Z tego powodu wprowadzono go także do sklepów w innych krajach. Świąteczną wersję Coca-Coli będzie można znaleźć również w Polsce. Według relacji niektórych Internautów, napój jest dostępny tylko w sieci Społem.. ...
https://prawy.pl/82471-nowy-smak-coca-coli-na-polskich-polkach/?replytocom=7034159
Swine | Bossowie w Darkest Dungeon - Darkest Dungeon - poradnik do gry | GRYOnline.plSwine | Bossowie w Darkest Dungeon - Darkest Dungeon - poradnik do gry | GRYOnline.pl
Swine jest drugim w kolejno ci bossem, kt ry okupuje lokacj Warrens. Z wygl du przypomina on wielk , nieumar ... c , wini . Z przerdzewia koron na g owi i masywnym tasakiem gotowym poci naszych bohater w na drobne kawa eczki. Boss ten posiada bardzo ciekaw mechanik opart na statusie Mark. Jego ma y towarzysz, Wilbur, kt ry stoi zawsze za swoim kr lem, posiada zdolno oznaczania cel w. Dwa z trzech atak w bossa mog by aktywowane jedynie na oznaczonych celach, natomiast ten ostatni posiada bardzo nisk szans na trafienie. Dzi ki tej mechanice b dziesz w stanie przewidzie kto z Twojej dru yny zostanie zaatakowany i odpowiednio si do tego przygotowa . Warto r wnie w wspomnie , e pr ba zabicia Wilbura przed wyko czeniem bossa mo e nie by wcale takim dobrym pomys em. Po mierci swojego poddanego, Swine wpada w dziki sza i odblokowuje specjalny atak - Enraged Destruction. Umiej tno ta zadaje bardzo du e obra enia wszystkim cz onkom dru yny, a do tego ma szans na o y efekt Stun. Z tego konkretnego powodu ...
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BiguanideBiguanide
The mechanism of action of biguanides is not fully understood, and many mechanisms have been proposed for metformin. Biguanides ... Biguanide can be obtained from the reaction of dicyandiamide with ammonia, via a Pinner-type process. C 2 H 4 N 4 + N H 3 ⟶ C 2 ... Biguanide (/baɪˈɡwɒnaɪd/) is the organic compound with the formula HN(C(NH)NH2)2. It is a colorless solid that dissolves in ... Biguanides also tend to make the cells of the body more willing to absorb glucose already present in the bloodstream, and there ...
https://en.wikipedia.org/wiki/Biguanide
Polyaminopropyl biguanidePolyaminopropyl biguanide
... (PAPB) is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions ... Gerit D. Mulder, Joseph P. Cavorsi and Daniel K. Lee (2007). "Polyhexamethylene Biguanide (PHMB): An Addendum to Current ... 2006). "The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide". Microbiology. 152 (4): 989- ... Antimicrobial resistance Polyhexanide, a related biguanide disinfectant Benzalkonium chloride Stearalkonium chloride ...
https://en.wikipedia.org/wiki/Polyaminopropyl_biguanide
BuforminBuformin
Biguanides were first noted to be active against influenza in the 1940s. Further studies confirmed their antiviral activity in ... Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels. After oral administration of 50 mg of ... Beckmann R (March 1968). "The fate of biguanides in man". Annals of the New York Academy of Sciences. 148 (3): 820-32. Bibcode: ... The bioavailability of oral buformin and other biguanides is 40%-60%. Binding to plasma proteins is absent or very low. The ...
https://en.wikipedia.org/wiki/Buformin
Animesh ChakravortyAnimesh Chakravorty
Chakravorty, Animesh; Basu, Sadhan (5 March 1960). "Crystal Spectrum of Copper Biguanides". Nature. 185 (4714): 681. doi: ...
https://en.wikipedia.org/wiki/Animesh_Chakravorty
Karl SlottaKarl Slotta
K. H. Slotta; R. Tschesche (1929). "Uber Biguanide. II. Die Blutzuckersenkende Wirkung der Biguanides. Berichte der Deutschen ...
https://en.wikipedia.org/wiki/Karl_Slotta
MetforminMetformin
... is a biguanide antihyperglycemic agent. It works by decreasing glucose production in the liver, by increasing the ... The biguanide class of antidiabetic medications, which also includes the withdrawn agents phenformin and buformin, originates ... Broad interest in metformin was not rekindled until the withdrawal of the other biguanides in the 1970s. Metformin was approved ... Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ (February 2013). "Biguanides suppress hepatic glucagon signalling by ...
https://en.wikipedia.org/wiki/Metformin
Glossary of diabetesGlossary of diabetes
Metformin A drug treatment for type 2 diabetes; belongs to a class of drugs called biguanides. First-line pharmacotherapy for ...
https://en.wikipedia.org/wiki/Glossary_of_diabetes
Antimalarial medicationAntimalarial medication
Proguanil (chloroguanide) is a biguanide; a synthetic derivative of pyrimidine. It was developed in 1945 by a British ...
https://en.wikipedia.org/wiki/Antimalarial_medication
ChlorhexidineChlorhexidine
Polyaminopropyl biguanide Polyhexanide Triclosan Varoni, E.; Tarce, M.; Lodi, G.; Carrassi, A. (September 2012). "Chlorhexidine ... Tanzer JM, Slee AM, Kamay BA (1977). "Structural requirements of guanide, biguanide, and bisbiguanide agents for antiplaque ... Biguanides, Chloroarenes, Disinfectants, Oral hygiene, Otologicals, World Health Organization essential medicines, Wikipedia ...
https://en.wikipedia.org/wiki/Chlorhexidine
PolyhexanidePolyhexanide
... (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it ... Polyaminopropyl biguanide "Classification and Labelling of PHMB". European Chemicals Agency. Ansorg R, Rath PM, Fabry W (2003 ... Biguanides, Polymers, All stub articles, Polymer stubs, Dermatologic drug stubs). ...
https://en.wikipedia.org/wiki/Polyhexanide
BisbiguanideBisbiguanide
They are named for having two biguanide moieties, which themselves are named for having two guanide parts. Bisbiguanide ... v t e (Antiseptics, Biguanides, All stub articles, Antiinfective agent stubs). ... compounds - Patent 4670592 Tanzer JM, Slee AM, Kamay BA (1977). "Structural requirements of guanide, biguanide, and ...
https://en.wikipedia.org/wiki/Bisbiguanide
AlexidineAlexidine
... is an antimicrobial of the biguanide class. More specifically, it is a bisbiguanide. Barrios, Rocío; Ferrer-Luque, ... Tanzer JM, Slee AM, Kamay BA (1977). "Structural requirements of guanide, biguanide, and bisbiguanide agents for antiplaque ... Biguanides, All stub articles, Antiinfective agent stubs). ...
https://en.wikipedia.org/wiki/Alexidine
PhenforminPhenformin
... is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most ... Vladimir Dilman first proposed in 1971 that biguanides like metformin and phenformin may have potential to treat cancer, ...
https://en.wikipedia.org/wiki/Phenformin
DisinfectantDisinfectant
Thymol Pine oil The biguanide polymer polyaminopropyl biguanide is specifically bactericidal at very low concentrations (10 mg/ ... Vijayakumar R, Kannan VV, Sandle T, Manoharan C (May 2012). "In vitro Antifungal Efficacy of Biguanides and Quaternary Ammonium ... "The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide". Microbiology. 152 (4): 989-1000. doi: ...
https://en.wikipedia.org/wiki/Disinfectant
Cori cycleCori cycle
Sirtori CR, Pasik C (1994). "Re-evaluation of a biguanide, metformin: mechanism of action and tolerability". Pharmacological ...
https://en.wikipedia.org/wiki/Cori_cycle
Seymour ShapiroSeymour Shapiro
The work for Shapiro's doctoral thesis, "Reaction of Phenyl Biguanide with Esters and Related Compounds", published in JACS in ... We had for some time considered investigating the hypoglycemic properties of our biguanide compounds... Of the more than 260 ... The subject range included blood chemistry, anesthetics, androgens, biguanides, diuretics, indanols, indandiones, triazines and ... biguanide compounds derivatized on the 1 and 1,5 nitrogens, it is unusual that of the 6 to 8 compounds found to be safe and ...
https://en.wikipedia.org/wiki/Seymour_Shapiro
HypoglycemiaHypoglycemia
The most common cause of hypoglycemia is medications used to treat diabetes such as insulin, sulfonylureas, and biguanides. ... Diabetes medications, like insulin, sulfonylureas, and biguanides can also be adjusted or stopped to prevent hypoglycemia. ... and biguanides. This is often due to excessive doses or poorly timed doses. Sometimes diabetics may take insulin in ...
https://en.wikipedia.org/wiki/Hypoglycemia
Diabetes medicationDiabetes medication
Biguanides reduce hepatic glucose output and increase uptake of glucose by the periphery, including skeletal muscle. Although ... These include: Sulfonylureas - glimepiride, glipizide, glyburide Biguanides - metformin Thiazolidinediones (Tzd) - pioglitazone ... it must be used with caution in patients with impaired liver or kidney function, metformin, a biguanide, has become the most ...
https://en.wikipedia.org/wiki/Diabetes_medication
Antimicrobial polymerAntimicrobial polymer
... synthesis and antibacterial activities of polycations with pendant biguanide groups". Antimicrob. Agents Chemother. 26 (2): 139 ...
https://en.wikipedia.org/wiki/Antimicrobial_polymer
Fusarium solaniFusarium solani
Prevention also includes leaving lenses in polyhexanide biguanide solution overnight to inhibit F. solani. Other risk factors ...
https://en.wikipedia.org/wiki/Fusarium_solani
AnovulationAnovulation
Metformin, a biguanide, is a common insulin sensitizer often given to treat women with PCOS. No other insulin sensitizers have ...
https://en.wikipedia.org/wiki/Anovulation
HL156AHL156A
... is a derivative of metformin and a potent OXPHOS inhibitor and AMPK activating biguanide. Certain types of cancer cells ... a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors". Journal of ... and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide ( ...
https://en.wikipedia.org/wiki/HL156A
Medical textilesMedical textiles
Polyhexamethylene biguanide (PHMB) treated CVC fabric (fabric with chief value cotton) kills 94% of the coronavirus in two ...
https://en.wikipedia.org/wiki/Medical_textiles
MedicationMedication
... biguanides/metformin, thiazolidinediones, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosphonate, vasopressin ...
https://en.wikipedia.org/wiki/Medication
BenfluorexBenfluorex
Roger P, Auclair J, Drain P (1999). "Addition of benfluorex to biguanide improves glycemic control in obese non-insulin- ...
https://en.wikipedia.org/wiki/Benfluorex
Acanthamoeba keratitisAcanthamoeba keratitis
One class of medications used in treatment is the biguanides, which include polyhexamethylene biguanide (PHMB) 0.02% to 0.06% ... Biguanides have also been found to act synergistically when used in combination with diamidines, with propamidine isethionate ... therapy is usually started with a combination of a biguanide and a diamidine. Early use of high dose dual therapy helps to ...
https://en.wikipedia.org/wiki/Acanthamoeba_keratitis
AntisepticAntiseptic
It is also used in mouthwashes to treat inflammation of the gums (gingivitis). Polyhexanide (polyhexamethylene biguanide, PHMB ...
https://en.wikipedia.org/wiki/Antiseptic
Wound bed preparationWound bed preparation
Polyhexamethylene biguanide hydrochloride is a fast-acting, broad-spectrum synthetic compound that binds to the cell envelope ... The study group received the Polyhexamethylene biguanide solution (n=59) and the control group received either Ringer's ... A retrospective analysis of wound cleanser clinical efficacy and cost-effectiveness focussed on Polyhexamethylene biguanide ...
https://en.wikipedia.org/wiki/Wound_bed_preparation
ChlorophenylbiguanideChlorophenylbiguanide
Schlicker E, Kathmann M, Exner HJ, Detzner M, Göthert M (1994). "the 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide ...
https://en.wikipedia.org/wiki/Chlorophenylbiguanide
Priyadaranjan RayPriyadaranjan Ray
A great deal of his work concerned the chemistry of the biguanide ligand, in connection with which he discovered its third- and ... He designed several organic reagents including rubeanic acid, bismuthiol-I and biguanide for detecting and estimating metal ...
https://en.wikipedia.org/wiki/Priyadaranjan_Ray
Biguanides: MedlinePlus Medical Encyclopedia ImageBiguanides: MedlinePlus Medical Encyclopedia Image
Biguanides (Metformin) tell the liver to decrease its production of glucose, which lowers glucose levels in the bloodstream. ... Biguanides (Metformin) tell the liver to decrease its production of glucose, which lowers glucose levels in the bloodstream. ...
https://medlineplus.gov/ency/imagepages/19827.htm
Pediatric Type 2 Diabetes Mellitus Medication: Biguanides, Sulfonylureas, Meglitinides, Alpha-glucosidase inhibitors,...Pediatric Type 2 Diabetes Mellitus Medication: Biguanides, Sulfonylureas, Meglitinides, Alpha-glucosidase inhibitors,...
Biguanides. Class Summary. These agents reduce hepatic glucose production; they also increase peripheral insulin sensitivity. ...
https://www.medscape.com/answers/925700-176594/which-medications-in-the-drug-class-antidiabetics-insulins-are-used-in-the-treatment-of-pediatric-type-2-diabetes-mellitus
Metabolic Syndrome Medication: Antidiabetics, Biguanides, Antidiabetics, Thiazolidinediones, Lipid-Lowering Agents, Statins,...Metabolic Syndrome Medication: Antidiabetics, Biguanides, Antidiabetics, Thiazolidinediones, Lipid-Lowering Agents, Statins,...
Metabolic syndrome is a multiplex risk factor that arises from insulin resistance accompanying abnormal adipose deposition and function. It is a risk factor for coronary heart disease, as well as diabetes, fatty liver, and several cancers.
http://emedicine.medscape.com/article/165124-medication
Antimalarial biguanides | RxWikiAntimalarial biguanides | RxWiki
Free Biguanide SanitizerFree Biguanide Sanitizer
Free A Biguanide Sanitizer by Leisure Time The Free Sanitizer by Leisure Time is the third step in the Free Sanitizing System ... Free A Biguanide Sanitizer by Leisure Time. The Free Sanitizer by Leisure Time is the third step in the Free Sanitizing System ... Free Sanitizer is a bromine-free, chlorine-free and odor-free biguanide sanitizer. It controls bacteria longer than chlorine or ...
https://www.familyleisure.com/Spa-Supplies/Free-Biguanide-Sanitizer
Hayward Strainer Cover Biguanide Sanitizers | In The SwimHayward Strainer Cover Biguanide Sanitizers | In The Swim
STRAINER COVER, BIGUANIDE SANITIZERS More Details Membership Available Quantity. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 ...
https://intheswim.com/p/strainer-cover-biguanide-sanitizers/626402.html
Drugs and patents in ATC class A10BA - BiguanidesDrugs and patents in ATC class A10BA - Biguanides
Drugs in ATC Class: A10BA - Biguanides drug patent expirations, market exclusivity, and generic launch dates. ...
https://www.drugpatentwatch.com/p/atc-class/A10BA
Bromine and Biguanide Pool Systems - Central Jersey PoolsBromine and Biguanide Pool Systems - Central Jersey Pools
Posted in Pool Articles and tagged biguanide pool, biguanide sanitizer, biguanide system, bromine pools, bromine system, pool ... h3,Biguanide Systems,/h3,. Biguanide systems have three effective agents: sanitizer, shock, and algaecide. Biguanides are ... Biguanide sanitizers are not affected by heat or sunlight. This means they do not burn off faster in hot weather.. To shock a ... With Biguanide systems, it is very important to make sure that chemicals are compatible. You can ask us at Central Jersey Pools ...
https://centraljerseypools.com/bromine-and-biguanide-pool-systems/
biguanide - Eckher Dictionarybiguanide - Eckher Dictionary
... biguanide (English). Eckher Dictionary is a multilingual pronunciation dictionary. ...
https://www.eckher.com/c/21h5r24ngd?q=biguanide
Endocrine Pharmacology- Section II - Biguanides (Metformin) - PhyseoEndocrine Pharmacology- Section II - Biguanides (Metformin) - Physeo
biguanide - Diabetes Information Librarybiguanide - Diabetes Information Library
Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Information on this site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. You should read carefully all product packaging. You should consult with a healthcare professional before starting any diet, exercise or supplementation program. Do not discontinue the use of prescription medication without the approval of your physician. User is solely responsible for their use of any content provided. Third party literature provided for informational purposes only and not to provide medical advice or to support claims for nutrient benefits. ...
http://diabetichealthinfo.com/encyclopedia/biguanide/
Biguanide - Generic online medicineBiguanide - Generic online medicine
Subscribe to our Newsletter & never miss a latest product or ...
https://genericonlinemedicine.com/product-category/biguanide/
JoF | Free Full-Text | Candida spp./Bacteria Mixed BiofilmsJoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms
0.2% polyhexamethilene biguanide (PHMB). Antimicrobial. Antibiofilm. [135]. Candida albicans, Streptococcus mutans. Association ... The antimicrobial activity of 0.2% polyhexamethilene biguanide (PHMB) to 2.5% NaOCl and 0.2% CHX in root canal models infected ... Antimicrobial effectiveness of polyhexamethylene biguanide on Enterococcus faecalis, Staphylococcus epidermidis and Candida ...
https://www.mdpi.com/2309-608X/6/1/5
1-(3-Chlorophenyl)biguanide hydrochloride | VWR1-(3-Chlorophenyl)biguanide hydrochloride | VWR
... biguanide hydrochloride. We enable science by offering product choice, services, process excellence and our people make it ...
https://ca.vwr.com/store/category/en/1-3-chlorophenyl-biguanide-hydrochloride/12148785
Klercide Quat/Biguanide Concen. 100ml - KlercideKlercide Quat/Biguanide Concen. 100ml - Klercide
Klercide Amine Quat/Biguanide Concentrate är lämplig att använda för rengöring och desinfektion av stora ytor så som golv, ... Klercide Quat/Biguanide innehåller en kvartär ammoniumförening samt en biguanid vilket ger bred aktivitet mot mikroorganismer. ...
https://lindhskontorsmaterial.se/produkt/klercide-quat-biguanide-concen-100ml/
1-(o-Tolyl)biguanide | 93-69-6 | Sarchem Labs1-(o-Tolyl)biguanide | 93-69-6 | Sarchem Labs
... biguanide , 93-69-6 available for purchase from Sarchem laboratories. please contact us for pricing and lead-time ...
https://www.sarchemlabs.com/product/1-o-tolylbiguanide/
IMSEAR at SEARO: Blood lactate and pyruvate levels in diabetic patient treated with sulphonylureas with and without biguanides.
Blood lactate and pyruvate levels in diabetic patient treated with sulphonylureas with and without biguanides. ... Blood lactate and pyruvate levels in diabetic patient treated with sulphonylureas with and without biguanides. Journal of the ...
https://imsear.searo.who.int/handle/123456789/41914
1-(4-Fluorophenyl)biguanide hydrochloride | 1C10217 | 16018-83-0 | | MFCD000519861-(4-Fluorophenyl)biguanide hydrochloride | 1C10217 | 16018-83-0 | | MFCD00051986
... biguanide hydrochloride,[H]Cl.NC(=N)NC(=N)NC1=CC=C(F)C=C1,C8H10N5F.HCl,MFCD00051986,1-(4-Fluorophenyl)biguanide ...
http://www.1clickchemistry.com/Product/ProductDetails/1C10217
Kinetics of silver(I)-catalysed oxidation of hydrazinium ion by the [ethylenebis(biguanide)]silver(III) cation - Publications...Kinetics of silver(I)-catalysed oxidation of hydrazinium ion by the [ethylenebis(biguanide)]silver(III) cation - Publications...
Kinetics of silver(I)-catalysed oxidation of hydrazinium ion by the [ethylenebis(biguanide)]silver(III) cation ... Silver(I) strongly catalyses the quantitative oxidation of hydrazine to dinitrogen by the complex [ethylenebis(biguanide)] ... biguanide)]silver(III) cation Journal of the Chemical Society Dalton Transactions, 1990 (7). pp. 2271-2275. ISSN 1472-7773 ...
http://repository.ias.ac.in/59972/
Pediatric Type 2 Diabetes Mellitus Medication: Biguanides, Sulfonylureas, Meglitinides, Alpha-glucosidase inhibitors,...
VivaViva
The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in manThe effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man
Biguanides / therapeutic use* * Dental Plaque / drug therapy* * Gingivitis / drug therapy* * Gluconates * Humans ...
https://pubmed.ncbi.nlm.nih.gov/4254172/?dopt=Abstract
Hayward Cover Kit, NorthStar 2007 & Prior Biguanide Sanitizer - SPX4000DLTB Discontinued - INYOPools.comHayward Cover Kit, NorthStar 2007 & Prior Biguanide Sanitizer - SPX4000DLTB Discontinued - INYOPools.com
Cover Kit, NorthStar 2007 & Prior Biguanide Sanitizer - SPX4000DLTB Discontinued It appears that your browser has JavaScript ... Hello Maryanne, depending on what style pump you had this lid Cover Kit, Northstar 2007 & Prior Biguanide Saniti goes to ...
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SpaGuard SoftSoak Shock-Oxidizer (1 QT) (BIGUANIDE SPAS ONLY) - Cozy Pools and Spas
SpaGuard SoftSoak Shock-Oxidizer (1 QT) (BIGUANIDE SPAS ONLY). * $18.09 $18.09 Unit price/ per ... Home › SpaGuard SoftSoak Shock-Oxidizer (1 QT) (BIGUANIDE SPAS ONLY) .selector-wrapper select, .product-variants select { ...
https://shopcozypools.com/products/spaguard-softsoak-shock-oxidizer-1-qt
JCI - Role of AMP-activated protein kinase in mechanism of metformin actionJCI - Role of AMP-activated protein kinase in mechanism of metformin action
Schafer, G. Biguanides. A review of history, pharmacodynamics and therapy. Diabete Metab 1983. 9:148-163. View this article via ...
https://www.jci.org/articles/view/13505?content_type=full
DailyMed - LEVOTHYROXINE SODIUM tabletDailyMed - LEVOTHYROXINE SODIUM tablet
Biguanides. - Meglitinides. - Sulfonylureas. - Thiazolidediones. - Insulin. Addition of levothyroxine to antidiabetic or ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0213903b-9662-465e-a668-f228cedf5e9e
MetforminPolyhexamethylene BiguanideInhibitorsSanitizersKnown as biguanidesSanitizerHaywardDipeptidylSulfonylureaDerivativesBiocideHypoglycemiaSulphonylureasBelongsTypeActiveContentCompatiblePHMBPolyhexamethyleneChlorineHydrochlorideEffects of biguanidesInsulinPolyaminopropylSanitizersInhibitorsChlorhexidineLactic acidosisAntimicrobialCationicQuaternaryPhenforminSpasDrugsCell membranesLiverAnti-diabeticBacteriaDiabetesGlucophageHydrogen peroxideBaquacilDisinfectantsToxicityComplexesIngredientPools treatedSynergisticBacterial
Metformin10
  • Biguanides (Metformin) tell the liver to decrease its production of glucose, which lowers glucose levels in the bloodstream. (medlineplus.gov)
  • 1,1-Dimethylbiguanide, commonly known as metformin, is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. (hmdb.ca)
  • Metformin is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (hmdb.ca)
  • Glimepiride is a sulfonylurea which acts by making the pancreas secrete more insulin to digest the circulating glucose and metformin is biguanide which acts by blocking the production of glucose by the liver. (netmeds.com)
  • Metformin is a biguanide anti-diabetic that works by decreasing the amount of sugar that the liver produces and the intestines absorb. (canadianolpharmacy.com)
  • Metformin belongs to a category of drugs known as biguanides. (20mg-cheapesttadalafil.com)
  • Metformin is a biguanide which effectively reduces the total amount of sugar released into the blood by the liver. (netmeds.com)
  • Metformin hydrochloride, a biguanide, is the most popular oral glucose-lowering medication in most countries, widely viewed as 'foundation therapy' for individuals with newly diagnosed type 2 diabetes mellitus. (researchwap.net)
  • However, a diabetic person is less prone to getting Hypoglycemia if he is taking biguanides like metformin, thiazolidinediones, and alpha-glucosidase inhibitors alone But if you are having these with insulin or Sulfonylureas, there are chances of getting low blood sugar. (gmfea.org)
  • Known hypersensitivity to Doxycycline Hyclate or other Tetracyclines and/or Metformin/Biguanide group or any excipients or any related drug or any substance. (who.int)
Polyhexamethylene Biguanide1
  • To analyze the effectiveness of polyhexamethylene biguanide (PHMB) compared to saline on the microbial load of wounds. (bvsalud.org)
Inhibitors1
  • If you take of cardiomyopathy is for my prescription Depakote and 25g biguanides, or the alphaglucosidase inhibitors. (esteticalink.com)
Sanitizers3
Known as biguanides1
  • Belongs to the class of organic compounds known as biguanides. (hmdb.ca)
Sanitizer2
  • Free Sanitizer is a bromine-free, chlorine-free and odor-free biguanide sanitizer. (familyleisure.com)
  • Biguanide systems have three effective agents: sanitizer, shock, and algaecide. (centraljerseypools.com)
Hayward1
  • Hello Maryanne, depending on what style pump you had this lid Cover Kit, Northstar 2007 & Prior Biguanide Saniti goes to Hayward Northstar 1998 to 2007 so please look at your pump and look to see whether you have a model number we can go off of to help you find your lid needed. (inyopools.com)
Dipeptidyl1
  • Dipeptidyl peptidase-4 (DPP-4) inhibitor + biguanide. (empr.com)
Sulfonylurea2
  • Sulfonylurea + biguanide. (clinicaladvisor.com)
  • Almost 39 (n = 62 717) of the ""combination therapy"" prescriptions were for a sulfonylurea in combination with a biguanide plus at least one other antidiabetic product. (bvsalud.org)
Derivatives1
  • Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES . (bvsalud.org)
Biocide1
  • Similarly to chlorhexidine, CosmocilTM, also from biguanide group, is a broad-spectrum biocide acting against gram-positive and gram-negative bacteria, yeast, and fungi. (bvsalud.org)
Hypoglycemia1
Sulphonylureas2
  • IMSEAR at SEARO: Blood lactate and pyruvate levels in diabetic patient treated with sulphonylureas with and without biguanides. (who.int)
  • Sitprija S, Vajanamarhutue C, Bunnag S. Blood lactate and pyruvate levels in diabetic patient treated with sulphonylureas with and without biguanides. (who.int)
Belongs1
  • It belongs to a class of medications called biguanides. (healthline.com)
Type1
  • A biguanide antihyperglycemic used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus. (drugbank.com)
Active1
  • To shock a biguanide pool, a liquid is added whose active ingredient is hydrogen peroxide to burn off organic matter. (centraljerseypools.com)
Content1
  • http://pubs.rsc.org/en/content/articlelanding/1990. (ias.ac.in)
Compatible1
  • With Biguanide systems, it is very important to make sure that chemicals are compatible. (centraljerseypools.com)
PHMB10
  • Polyhexamethylene biguanide (PHMB) is a kind of broad-spectrum antibacterial agent recognized as the safest and most efficient in the 21st century. (qzebright.com)
  • Polyhexamethylene biguanide (PHMB) is compatible with pigments in a wide range, such as nitrogen and sulfonates. (qzebright.com)
  • Biguanide is polyhexamethylene biguanide or shortened as PHMB. (serumwatercare.com)
  • Poly (hexamethylene) biguanide hydrochloride [PHMB] seems to be a suitable antiseptic agent for this purpose since previous studies revealed a low cytotoxicity and a long-lasting microbicidal effect of Ti6Al4V alloy coated with PHMB. (springer.com)
  • As an alternative, non-leachable coatings that kill bacteria upon contact [ 23 , 24 ] as for instance tightly adsorbed poly (hexamethylene) biguanide hydrochloride [PHMB] can minimize the probability of bacterial resistance formation. (springer.com)
  • A potentiometric titration method using a cationic surfactant as an indicator cation and a plasticized poly(vinyl chloride) membrane electrode sensitive to the cationic surfactant is proposed for the determination of polyhexamethylene biguanide hydrochloride (PHMB-HCl), which is a cationic polyelectrolyte. (elsevier.com)
  • Polyhexamethylene biguanide (PHMB) is an antiseptic polymer that is mainly used for cleaning hospitals and pools and combating Acantamoeba infection. (biomedcentral.com)
  • Previous work has shown that polyhexamethylene biguanide (PHMB) was effective in selectively killing the yeasts that are regarded as contaminants of the ethanol fermentation process, with special attention being paid to Dekkera bruxellensis [ 1 ]. (biomedcentral.com)
  • Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. (chemicalbook.com)
  • Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. (chemicalbook.com)
Polyhexamethylene1
  • A new product containing polyhexamethylene biguanide is described in greater detail with relevant case presentations and cost data. (medscape.com)
Chlorine11
  • You must drain and clean your spa if you are converting from chlorine or bromine to biguanide. (serumwatercare.com)
  • And biguanide is not compatible with the common oxidizers used in spas to remove these wastes, notably MPS (non-chlorine based shock) and ozone. (serumwatercare.com)
  • Biguanide is quite gentle, hence a possible solution if chlorine or bromine bother your skin. (serumwatercare.com)
  • Biguanide is completely incompatible with chlorine & bromine. (serumwatercare.com)
  • Issues such as mold and pink slime are more common when using biguanide than chlorine & bromine. (serumwatercare.com)
  • Unlike chlorine, biguanide is not an oxidizer, so it does not irritate your body by reacting or "burning up" organic contaminants the way chlorine does. (gochemless.com)
  • biguanide based spa sanitizer is virtually odor-free and controls bacteria longer than chlorine or bromine. (lesliespool.com)
  • The biofilm, which looks like white tissue paper or toilet paper, is resistant to chlorine, bromine and biguanide. (ehow.co.uk)
  • Chlorine, bromine, ozone and biguanide sanitizers. (yardandpool.com)
  • For chlorine or bromine spas, levels of Total Alkalinity up to 200 ppm are acceptable, and the high cutoff is 170 for Biguanide spas. (hottubwarehouse.com)
  • With its patented biotechnology, Saniswiss bio sanitizer is free of alcohol, aldehyde, biguanide, chlorine, phenol VOC (Volatile Organic Compounds) and other hazardous chemicals or compounds. (healthculture.com.hk)
Hydrochloride1
  • The chemical name of proguanil hydrochloride USP is 1-(4-chlorophenyl)-5-isopropyl-biguanide hydrochloride. (nih.gov)
Effects of biguanides1
  • and effects of biguanides on gluconeogenesis in rats and guinea pigs. (elsevier.com)
Insulin4
  • Glucophage XR belongs to a group of drugs called biguanides, which work by helping your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes , and decreasing the amount of sugar your intestines absorb. (rxwiki.com)
  • 17. Vanadyl-biguanide complexes as potential synergistic insulin mimics. (nih.gov)
  • The action of biguanides is to stimulate the effect of insulin. (lovelife-ya.com)
  • [3] , [4] Insulin and oral hypoglycemic agents are the most widely used drugs for lowering blood sugar in diabetes, but these drugs also have various side effects such as hypoglycemia, weight gain (sulfonylurea), and lactic acidosis (biguanides), and all of these drugs can cause liver and renal damage. (ayujournal.org)
Polyaminopropyl8
  • Does your micellar solution contain polyaminopropyl biguanide? (parokeets.com)
  • A friend of mine who works in the cosmetic making industry, published a while ago warning in a post on her forum Ars Cosmetica (CLICK HERE - Slovenian) about polyaminopropyl biguanide ingredient found in micellar solutions . (parokeets.com)
  • This is not products recall or something super poisonous, but I personally stopped using my micellar solutions which contained polyaminopropyl biguanide. (parokeets.com)
  • 5 thoughts on "Does your micellar solution contain polyaminopropyl biguanide? (parokeets.com)
  • PB MicroCide (Polyaminopropyl biguanide) is a gentle, paraben-free and formaldehyde-free preservative. (theherbarie.com)
  • A 2016 study found that multipurpose products containing the disinfectants chlorhexidine, polyaminopropyl biguanide (PAPB), and the antibacterial preservative ethylenediaminetetraacetic acid (EDPA) were effective against germs that cause keratitis , an inflammation of the cornea. (medicalnewstoday.com)
  • Polyaminopropyl Biguanide is a preservative. (ainostoria.com)
  • Polyaminopropyl Biguanide е консервант. (ainostoria.com)
Sanitizers1
  • Likely because biguanide is gentler than halogen sanitizers, issues with mold and pink slime are not uncommon in biguanide spas. (serumwatercare.com)
Inhibitors2
  • We now report that novel biguanide and bisguanidine polyamine analogues are potent inhibitors of LSD1. (nih.gov)
  • Biguanides and dipeptidyl peptidase-4 inhibitors were widely prescribed. (bvsalud.org)
Chlorhexidine1
  • Similarly to chlorhexidine, CosmocilTM, also from biguanide group, is a broad-spectrum biocide acting against gram-positive and gram-negative bacteria, yeast, and fungi. (bvsalud.org)
Lactic acidosis1
  • In children, hypoglycemia is particularly severe when poisoning following fasting, exercise or chronic malnutrition Lactic acidosis may occur in patients with severe liver disease, pancreatitis or receiving biguanide therapy or as a result of the hypovolemia which frequently accompanies severe intoxication. (nih.gov)
Antimicrobial1
  • WRAP-biguanide-iridium-complexes-potent-antimicrobial-activity-Chen-2018.pdf - Accepted Version - Requires a PDF viewer. (warwick.ac.uk)
Cationic1
  • Solution-Induced Corneal Staining (SICS), related to the use of certain contact lens care solutions, may have a different basis, involving the non-pathological uptake of cationic preservatives, such as biguanides, into epithelial membranes and secondary binding of the fluorescein anion. (harvard.edu)
Quaternary2
  • These include the amphoterics (based on amyl alkyl glycines), the cationics (quaternary ammonium compounds - known as QACs or quats) and biguanides/diguanides. (hse.gov.uk)
  • However, quaternary ammonium compounds, biguanides (i.e. surface active agents) and phenolics are considered as high-risk biocides concerning resistance problems [ 7 ]. (springeropen.com)
Phenformin1
  • From the 1950s to the 1970s, the leading drug in the biguanide class was phenformin. (nih.gov)
Spas3
  • Two popular brands of biguanide for spas are Baquacil & Soft-Swim. (serumwatercare.com)
  • The cutoff is slightly lower for Biguanide spas due to the foaming tendency of the product and the tendency for pH to drift upward. (hottubwarehouse.com)
  • is balanced once per season in most pools and is not required in spas or in biguanide treated pools. (imperialpoolsb2b.com)
Drugs1
  • Summary: A new study reveals statins, biguanides and other drugs that help treat physical conditions may have significant benefits for the treatment of bipolar disorder and schizophrenia. (neurosciencenews.com)
Cell membranes1
  • It's thought that biguanides stick to cell membranes, causing them to leak small molecules, and making proteins form solid deposits. (compoundchem.com)
Liver1
  • Biguanide therapy is forbidden in cases of liver diseases. (koser-piac.hu)
Anti-diabetic1
  • Metlife is an anti-diabetic medication (biguanide). (arogga.com)
Bacteria3
  • Biguanides attached to single cell organisms, notably bacteria, causing the cell wall to break. (serumwatercare.com)
  • As noted above, biguanide is not an oxidizer, hence it has no ability to rid your spa of biologic wastes, including dead bacteria, dead skin cells, etc. (serumwatercare.com)
  • Biguanides are active against bacteria, and show a degree of activity against viruses and fungi which can be enhanced by combination with other agents. (compoundchem.com)
Diabetes1
  • Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES . (nih.gov)
Glucophage1
Hydrogen peroxide2
  • Biguanide is just that, though it does require the use of hydrogen peroxide as an oxidizer. (serumwatercare.com)
  • You must use hydrogen peroxide as an oxidizer in a biguanide spa. (serumwatercare.com)
Baquacil2
  • Water purification additives containing Biguanide chemicals are sold under the trademarked names of Baquacil and Soft Swim. (gochemless.com)
  • Biguanide (which you may know under the brand name Baquacil ) doesn't cause white mold to grow in your pool. (swimuniversity.com)
Disinfectants1
  • Biguanides/diguanides are of low toxicity and irritancy and are useful skin disinfectants. (hse.gov.uk)
Toxicity1
  • Due to their low toxicity, biguanides can be used to treat wounds and in mouthwash. (compoundchem.com)
Complexes1
  • Investigations of reactions with biomolecules suggest that these organometallic complexes deliver active biguanides into microorganisms, whereas the biguanides themselves are inactive when administered alone. (warwick.ac.uk)
Ingredient1
  • The active ingredient in these products is known as Biguanide. (gochemless.com)
Pools treated1
  • Patented formula works specifically on filters of pools treated with poly-biguanide. (shopcozypools.com)
Synergistic1
  • The synergistic potential of a range of biguanides, their triazine metabolites, tetracyclines, and pyrimethamine in combination with atovaquone has been assessed. (nih.gov)
Bacterial1
  • Biguanides have a history starting in hospitals where they were and are used to quite effectively prevent bacterial growth. (serumwatercare.com)
Type 2 Diabetes Mellitus Treatment & Management: Approach Considerations, Pharmacologic Therapy, Management of Glycemia
Type 2 Diabetes Mellitus Treatment & Management: Approach Considerations, Pharmacologic Therapy, Management of Glycemia (medscape.com)
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JoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms (mdpi.com)
Acute Intermittent Porphyria Clinical Presentation: History, Physical Examination
Acute Intermittent Porphyria Clinical Presentation: History, Physical Examination (medscape.com)
Type 2 diabetes: MedlinePlus Medical Encyclopedia
Type 2 diabetes: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Lactic Acidosis: Background, Etiology, Epidemiology
Lactic Acidosis: Background, Etiology, Epidemiology (medscape.com)
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Perioperative Management of the Diabetic Patient: Practice Essentials, Physiology of Glucose Metabolism, General Preoperative... (emedicine.medscape.com)
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METFORMINE MYLAN PHARMA - Metformine chlorhydrate - Posologie (doctissimo.fr)
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Metformin: MedlinePlus Drug Information (medlineplus.gov)
DailyMed - LEVOTHYROXINE SODIUM tablet
DailyMed - LEVOTHYROXINE SODIUM tablet (dailymed.nlm.nih.gov)
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Biguanide - LAROUSSE (larousse.fr)
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Diabetes: Type 1, Type 2, Symptoms, Causes, Treatment, Diet, Blood Sugar Chart (rxlist.com)
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Metformin Side Effects: Common and Severe (healthline.com)
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Human Metabolome Database: Showing metabocard for 1,1-Dimethylbiguanide (HMDB0001921) (hmdb.ca)
Corneal Infections Associated with Sleeping in Contact Lenses - Six Cases, United States, 2016-2018 | MMWR
Corneal Infections Associated with Sleeping in Contact Lenses - Six Cases, United States, 2016-2018 | MMWR (cdc.gov)
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Qternmet XR (dapagliflozin/saxagliptin/metformin) dosing, indications, interactions, adverse effects, and more (reference.medscape.com)
Phenethylbiguanid | Diabeteslexikon | ernaehrung.de
Phenethylbiguanid | Diabeteslexikon | ernaehrung.de (ernaehrung.de)
British Contact Lens Association - Aston Research Explorer
British Contact Lens Association - Aston Research Explorer (research.aston.ac.uk)
Leisure Time Spa Balancer Liquid Spa Down 1 qt | Leslie's Pool Supplies
Leisure Time Spa Balancer Liquid Spa Down 1 qt | Leslie's Pool Supplies (lesliespool.com)