A small leucine-rich proteoglycan found in a variety of tissues including CAPILLARY ENDOTHELIUM; SKELETAL MUSCLE; CARTILAGE; BONE; and TENDONS. The protein contains two glycosaminoglycan chains and is similar in structure to DECORIN.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Glycoproteins which have a very high polysaccharide content.
Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.
HYALURONAN-containing proteoglycans found in the EXTRACELLULAR MATRIX of a variety of tissues and organs. Several versican isoforms exist due to multiple ALTERNATIVE SPLICING of the versican MESSENGER RNA.
A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.
A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
Transport proteins that carry specific substances in the blood or across cell membranes.
The teaching staff and members of the administrative staff having academic rank in a medical school.
A form of stimulus sensitive myoclonic epilepsy inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110)

Connective tissues: matrix composition and its relevance to physical therapy. (1/269)

In the last 2 decades, the understanding of CT structure and function has increased enormously. It is now clear that the cells of the various CTs synthesize a variety of ECM components that act not only to underpin the specific biomechanical and functional properties of tissues, but also to regulate a variety of cellular functions. Importantly for the physical therapist, and as discussed above, CTs are responsive to changes in the mechanical environment, both naturally occurring and applied. The relative proportions of collagens and PGs largely determine the mechanical properties of CTs. The relationship between the fibril-forming collagens and PG concentration is reciprocal. Connective tissues designed to resist high tensile forces are high in collagen and low in total PG content (mostly dermatan sulphate PGs), whereas CTs subjected to compressive forces have a greater PG content (mostly chondroitin sulphate PGs). Hyaluronan has multiple roles and not only provides tissue hydration and facilitation of gliding and sliding movements but also forms an integral component of large PG aggregates in pressure-resisting tissues. The smaller glycoproteins help to stabilize and link collagens and PGs to the cell surface. The result is a complex interacting network of matrix molecules, which determines both the mechanical properties and the metabolic responses of tissues. Patients with CT problems affecting movement are frequently examined and treated by physical therapists. A knowledge of the CT matrix composition and its relationship to the biomechanical properties of these tissues, particularly the predictable responses to changing mechanical forces, offers an opportunity to provide a rational basis for treatments. The complexity of the interplay among the components, however, requires that further research be undertaken to determine more precisely the effects of treatments on the structure and function of CTs.  (+info)

Distinct secondary structures of the leucine-rich repeat proteoglycans decorin and biglycan. Glycosylation-dependent conformational stability. (2/269)

Biglycan and decorin have been overexpressed in eukaryotic cells and two major glycoforms isolated under native conditions: a proteoglycan substituted with glycosaminoglycan chains; and a core protein form secreted devoid of glycosaminoglycans (Hocking, A. M., Strugnell, R. A., Ramamurthy, P., and McQuillan, D. J. (1996) J. Biol. Chem. 271, 19571-19577; Ramamurthy, P., Hocking, A. M., and McQuillan, D. J. (1996) J. Biol. Chem. 271, 19578-19584). Far-UV CD spectroscopy of decorin and biglycan proteoglycans indicates that, although they are predominantly beta-sheet, biglycan has a significantly higher content of alpha-helical structure. Decorin proteoglycan and core protein are very similar, whereas the biglycan core protein exhibits closer similarity to the decorin glycoforms than to the biglycan proteoglycan form. However, enzymatic removal of the chondroitin sulfate chains from biglycan proteoglycan does not induce a shift to the core protein structure, suggesting that the final form is influenced by polysaccharide addition only during biosynthesis. Fluorescence emission spectroscopy demonstrated that the single tryptophan residue, which is at a conserved position at the C-terminal domain of both biglycan and decorin, is found in similar microenvironments. This indicates that in this specific domain the different glycoforms do exhibit apparent conservation of structure. Exposure of decorin and biglycan to 10 M urea resulted in an increase in fluorescent intensity, which indicates that the emission from tryptophan in the native state is quenched. Comparison of urea-induced protein unfolding curves provide further evidence that decorin and biglycan assume different structures in solution. Decorin proteoglycan and core protein unfold in a manner similar to a classic two-state model, in which there is a steep transition to an unfolded state between 1 and 2 M urea. The biglycan core protein also shows a similar steep transition. However, biglycan proteoglycan shows a broad unfolding transition between 1 and 6 M urea, probably indicating the presence of stable unfolding intermediates.  (+info)

Decorin is a Zn2+ metalloprotein. (3/269)

Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high affinity for Zn2+ as demonstrated by equilibrium dialyses. The Zn2+-binding sites are localized to the N-terminal domain of the core protein that contains 4 Cys residues in a spacing reminiscent of a zinc finger. A recombinant 41-amino acid long peptide representing the N-terminal domain of decorin has full Zn2+ binding activity and binds two Zn2+ ions with an average KD of 3 x 10(-7) M. Binding of Zn2+ to this peptide results in a change in secondary structure as shown by circular dichroism spectroscopy. Biglycan, a proteoglycan that is structurally closely related to decorin contains a similar high affinity Zn2+-binding segment, whereas the structurally more distantly related proteoglycans, epiphycan and osteoglycin, do not bind Zn2+ with high affinity.  (+info)

Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism. (4/269)

A bovine nasal-cartilage culture system has been utilized to analyse the catabolic events occurring in response to interleukin-1beta over a 14-day period. An early event following the start of interleukin-1 treatment was the release of glycosaminoglycan into the culture medium. This release was accompanied by the appearance in the tissue, and shortly thereafter also in the culture media, of a globular domain (G1)-containing aggrecan degradation product generated by the action of aggrecanase. Link protein was also released from the cartilage with a similar timeframe to that of the G1 fragment, although there was no evidence of its proteolytic degradation. By comparison with aggrecan, the small leucine-rich repeat proteoglycans decorin, biglycan and lumican showed a resistance to both proteolytic cleavage and release throughout the culture period. In contrast, fibromodulin exhibited a marked decrease in size after day 4, presumably due to proteolytic modification, but the major degradation product was retained throughout the culture period. Also in contrast with the early changes in the components of the proteoglycan aggregate, type II collagen did not display signs of extensive degradation until much later in the culture period. Collagen degradation products compatible with collagenase action first appeared in the medium by day 10 and increased thereafter. These data demonstrate that the leucine-rich repeat proteoglycans are resistant to proteolytic action during interleukin-1-stimulated cartilage catabolism, compared with aggrecan. This resistance and continued interaction with the surface of the collagen fibrils may help to stabilize the collagen fibrillar network and protect it from extensive proteolytic attack during the early phases of cartilage degeneration.  (+info)

Differential regulation of extracellular matrix molecules by mechanical strain of fetal lung cells. (5/269)

We have previously shown that an intermittent mechanical strain regimen (5% elongation, 60 cycles/min, 15 min/h) that simulates fetal breathing movements stimulated fetal rat lung cell proliferation. Because normal lung growth requires proper coordination between cell proliferation and extracellular matrix (ECM) remodeling, we subjected organotypic cultures of fetal rat lung cells (day 19 of gestation, term = 22 days) to this strain regimen and examined alterations in ECM gene and protein expression. Northern analysis revealed that mechanical strain reduced messages for procollagen-alpha1(I) and biglycan and increased the levels of mRNA for collagen-alpha1(IV) and -alpha2(IV), whereas laminin beta-chain mRNA levels remained constant. Regardless of mRNA changes, mechanical strain increased the protein content of type I and type IV collagen as well as of biglycan in the medium. Mechanical strain did not affect gene expression of several matrix metalloproteinases (MMPs), such as MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), and MMP-3 (stromelysin-1). Neither collagenase nor gelatinase (A and B) activities in conditioned medium were affected by mechanical strain. Tissue inhibitor of metalloproteinase activities in conditioned medium remained unchanged during the 48-h intermittent mechanical stretching. These data suggest that an intermittent mechanical strain differentially regulates gene and protein expression of ECM molecules in fetal lung cells. The observed increase in matrix accumulation appears to be mainly a result of an increased synthesis of ECM molecules and not of decreasing activity of degradative enzymes.  (+info)

The macromolecular characteristics of cartilage proteoglycans do not change when synthesis is up-regulated by link protein peptide. (6/269)

Previous studies have shown that a synthetic, unglycosylated analogue of the N-terminal peptide from link protein can function as a growth factor and up-regulate proteoglycan biosynthesis in explant cultures of normal human articular cartilage from a wide age range of subjects (McKenna et al., Arthritis Rheum. 41 (1998) 157-162). The present work further shows that link peptide increased proteoglycan synthesis by cartilage cultured in both the presence and absence of serum, suggesting that the mechanism of up-regulation may be different from that of insulin-like growth factors. The proteoglycans synthesised during stimulation with link peptide were of normal hydrodynamic size and the ratio of core protein to glycosaminoglycan side chains and the proportions of the large proteoglycan aggrecan to the small proteoglycans, decorin and biglycan, remained constant. Aggrecan molecules were equally capable of forming aggregates as those from control tissues and the relative proportions of decorin and biglycan were unchanged showing that both were co-ordinately up-regulated. These results confirmed that this novel peptide is a potent stimulator of proteoglycan synthesis by articular cartilage and showed that the newly synthesised proteoglycans were of normal composition.  (+info)

External beam radiation after stent implantation increases neointimal hyperplasia by augmenting smooth muscle cell proliferation and extracellular matrix accumulation. (7/269)

OBJECTIVES: We sought to examine the effects of high volume external beam radiation (EBR) after stent implantation on neointimal hyperplasia, smooth muscle cell (SMC) proliferation, presence of inflammatory cells and expression of extracellular matrix (ECM). BACKGROUND: Endovascular irradiation has been shown to reduce restenosis rates after angioplasty in preliminary trials, but conflicting results have been reported for the effects of external beam irradiation. METHODS: Forty-three Palmaz-Schatz stents were implanted into iliac arteries of New Zealand White rabbits. The arteries were externally irradiated after stent implantation with a single dose of 8 Gy (at day 3) or 16 Gy in two fractions (8 Gy at days 3 and 4) by means of a linear accelerator. In the control rabbits, no radiation was applied after stent implantation. Smooth muscle cells, macrophages and ECM were studied by immunohistochemistry at one and 12 weeks after stent implantation. Collagen type I and biglycan messenger ribonucleic acid (mRNA) levels were assessed by Northern blot analysis at one week. Neointimal cell densities and arterial lumen stenosis were measured by histomorphometry at 12 weeks. RESULTS: At 1 week, SMC proliferation at the site of stent implantation was increased after EBR with 8 and 16 Gy (26 +/- 5%, 32 +/- 3% vs. 17 +/- 8%; p < 0.01, 16 Gy vs. control). External beam radiation with 8 and 16 Gy augmented SMC proliferation proximal and distal to the angioplasty site (11 +/- 3%, 14 +/- 3 vs. 6 +/- 1%; p < 0.01, 16 Gy vs. control). Collagen type I and biglycan mRNA levels were elevated in stented arteries after EBR with 16 Gy. At 12 weeks, a marked decrease in neointimal cell density (248 +/- 97 vs. 498 +/- 117 SMCs/0.1 mm2 neointima; p < 0.005 vs. control) was noted after EBR with 16 Gy. Irradiation with 8 and 16 Gy increased arterial lumen stenosis compared with nonirradiated control rabbits (45 +/- 7%, 55 +/- 9% vs. 33 +/- 7%; p < 0.05, 8 Gy and p < 0.001, 16 Gy vs. control). CONCLUSIONS: High volume external beam radiation at doses of 8 or 16 Gy causes restenosis by augmenting proliferative activity at and adjacent to the site of stent implantation, and by dose-dependent up-regulation of extracellular matrix expression. The study suggests that excessive matrix accumulation is an important determinant of failure of radiation therapy to prevent restenosis.  (+info)

Cyclic expression of mRNA transcripts for connective tissue components in the mouse ovary. (8/269)

In the ovary, differentiation of germinal cells into primordial follicles, functional ovulatory follicles and corpus luteum, all take place in a connective tissue matrix. We postulated that extracellular matrix (ECM) of the ovary participates actively in ovarian functions. To test this, the mRNA levels for several ECM components were determined in the mouse ovary at six distinct stages of the 4-day oestrous cycle. Northern analysis revealed statistically significant cyclic expression patterns for the mRNAs coding for type III, IV and VI collagens as well as for the small proteoglycan, biglycan, and for syndecan-1 and osteonectin. The cyclic changes observed in the mRNAs for these structural components exceeded those for matrix metalloproteinases (MMP)-2, -9 and -13, and for tissue inhibitors of matrix metalloproteinases (TIMP)-1, -2 and -3, where the changes were not statistically significant, despite their apparent role in ECM remodelling in the ovary. These observations support the hypothesis that cyclic changes in the production and degradation of ECM are part of normal ovarian function connected with follicular maturation, rupture and corpus luteum formation.  (+info)

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene which is located on the X chromosome. The name biglycan was proposed in an article by Fisher, Termine and Young in an article in the Journal of Biological Chemistry in 1989 because the proteoglycan contained two GAG chains; formerly it was known as proteoglycan-I (PG-I). Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS), with DS being more abundant in most connective tissues. The CS/DS chains are attached at amino acids 5 and 10 in human biglycan. The composition of the GAG chains has been reported as varying according to tissue of origin. Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. The composition of GAG ...
Introduction:Thrombin signalling initiates inflammatory events directly and through activation of platelets. Endogenous and pharmacologic inhibitors of thrombin are therefore of relevance during atheroprogression and for therapeutic intervention. The small leucine-rich proteoglycan biglycan (BGN) is thought to inhibit thrombin activity by activation of heparin cofactor II. Hypothesis: Genetic deletion of BGN affects thrombin activity, inflammation and atherosclerosis. Methods:Male mice deficient in apolipoprotein E and BGN (ApoE-/-/Bgn-/0) were compared with their ApoE-/- littermates.. Results: In ApoE-/- mice BGN was detected in the plasma and subendothelial matrix of capillaries, arterioles and in atherosclerotic plaques. In line with a role of BGN in balancing thrombin activity, ApoE-/-/Bgn-/0 mice exhibited higher activity of circulating thrombin and greater platelet activation than did ApoE-/- mice. Furthermore, higher concentrations of circulating cytokines in ApoE-/-/Bgn-/0 mice suggested ...
article{6b8e8868-1afd-41d6-808d-4fc5532ec3af, abstract = {The ability of the leucine-rich repeat (LRR) proteins biglycan, decorin and chondroadherin to interact with collagen VI and influence its assembly to supramolecular structures was studied by electron microscopy and surface plasmon resonance measurements in the BIAcore 2000 system. Biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes. Only the intact molecule, substituted with two dermatan sulfate chains, had this capacity. Intact decorin, with one dermatan sulfate chain only, was considerably less efficient and aggregates of organized collagen VI were found only after several hours. Chondroadherin without glycosaminoglycan substitutions did not induce any ordered collagen VI organization. However, all three related LRR proteins were shown to interact with collagen VI using electron microscopy and surface plasmon resonance. Biglycan and decorin were ...
Kiss, Krisztina and Csonka, Csaba and Pálóczi, János and Pipis, Judit and Görbe, Anikó and Kocsis, Gabriella F. and Murlasits, Zsolt and Sárközy, Márta and Szűcs, Gergő and Holmes, Christopher P. and Pan, Yijun and Bhandari, Ashok and Csont, Tamás Bálint and Shamloo, Mehrdad and Woodburn, Kathryn W and Ferdinandy, Péter and Bencsik, Péter (2016) Novel, selective EPO receptor ligands lacking erythropoietic activityreduce infarct size in acute myocardial infarction in rats. PHARMACOLOGICAL RESEARCH, 13 (Pt A). pp. 62-70. ISSN 1043-6618 Gáspár, Renáta and Pipicz, Márton and Hawchar, Fatime and Kovács, Dávid and Djirackor, Luna and Görbe, Anikó and Varga, Zoltán V and Kiricsi, Mónika and Petrovski, Goran and Gácser, Attila and Csonka, Csaba and Csont, Tamás (2016) The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes. Journal of molecular and cellular cardiology, 99. pp. 138-150. ISSN 1095-8584 Kiss, Krisztina and ...
Biglycan Antibody 16409-1-AP has been identified with IF, IHC, IP, WB, ELISA. 16409-1-AP detected 40-48 kDa band in COLO 320 cells with 1:500-1:1000 dilution...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
Biglycan Preproprotein antibody, C-term (biglycan) for IHC, WB. Anti-Biglycan Preproprotein pAb (GTX89194) is tested in Human, Rat samples. 100% Ab-Assurance.
Benaroya Research Institute & University of Washington - Cited by 32,105 - Extracellular matrix - Proteoglycans - Hyaluronan - Versican
Goat polyclonal antibody raised against synthetic peptide of BGN. A synthetic peptide corresponding to C-terminus of human BGN. (PAB7149) - Products - Abnova
Affiliation:Nihon University,School of Dentistry,Research Associate,歯学部,助手, Research Field:Morphological basic dentistry, Keywords:alkaline phosphatase,biglycan,proteoglycan,BMP,TGF-β,decorin,osteoblast,biolycan,culture,osteoblasts, # of Research Projects:1, # of Research Products:0
Rabbit Polyclonal Anti-Fibromodulin/FMOD Antibody. Validated: WB. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
Sequence variants and/or copy number variants (deletions/duplications) within the BGN gene will be detected with >99% sensitivity. Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported. Benign and likely...
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Looking for online definition of biglycan proteoglycan in the Medical Dictionary? biglycan proteoglycan explanation free. What is biglycan proteoglycan? Meaning of biglycan proteoglycan medical term. What does biglycan proteoglycan mean?
Decorin is a protein that in humans is encoded by the DCN gene. Decorin is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorins name is a derivative of both the fact that it decorates collagen type I, and that it interacts with the d and e bands of fibrils of this collagen. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal ...
In the present study, we sought to quantify and contrast the secretome and biomechanical properties of the non-chondrodystrophic (NCD) and chondrodystrophic (CD) canine intervertebral disc (IVD) nucleus pulposus (NP). We used iTRAQ proteomic methods to quantify the secretome of both CD and NCD NP. Differential levels of proteins detected were further verified using immunohistochemistry, Western blotting, and proteoglycan extraction in order to evaluate the integrity of the small leucine-rich proteoglycans (SLRPs) decorin and biglycan. Additionally, we used robotic biomechanical testing to evaluate the biomechanical properties of spinal motion segments from both CD and NCD canines. We detected differential levels of decorin, biglycan, and fibronectin, as well as of other important extracellular matrix (ECM)-related proteins, such as fibromodulin and HAPLN1 in the IVD NP obtained from CD canines compared with NCD canines. The core proteins of the vital SLRPs decorin and biglycan were fragmented in CD NP
Proteoglycans are macromolecules composed of a core protein and complex, linear, long-chain carbohydrates, called glycosaminoglycans (GAGs). GAGs consist of repeating disaccharide units bearing negatively charged sulfate and carboxy groups. GAGs are covalently bound to the core protein via a tetrasaccharide linkage [GlcA-Gal-Gal-Xyl]. There are distinct types of GAGs: chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS), heparin, keratan sulfate, and hyaluronan. Several classes of CS and DS containing proteoglycans are found in the artery. These include versican, a large CS containing proteoglycan, and biglycan and decorin, 2 small leucine-rich proteoglycans containing DS and CS/DS, respectively. HS containing proteoglycans, the syndecans and glypicans, are associated with the cell membrane of smooth muscle cells (SMCs) and endothelial cells. Perlecan, a ,500-kDa molecule that is the major HS in subendothelial matrix,16 is also an important component of the artery wall.. The ...
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and…
Specialized collagens and small leucine-rich proteoglycans (SLRPs) interact to produce the transparent corneal structure. In cornea plana, the forward convex curvature is flattened, leading to a decrease in refraction. A more severe, recessively inherited form (CNA2; MIM 217300) and a milder, domina …
FLRT1 Full-Length MS Protein Standard (NP_037412), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain.
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|strong|Mouse anti 17-beta-Estradiol antibody, clone 4S112 (BGN/06/88112)|/strong| recognizes 17-beta estradiol, a mammalian estrogenic hormone, produced in the ovaries, placenta and testis that has a…
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人Decorin ELISA试剂盒(DCN) ELISA试剂盒datasheet (ab99998).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽,使用效果保证,中国70%以上现货。
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Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. In a cross section study a total of 20 endometrial samples were collected from 10 patients with PCOS and 10 ovulatory women during their proliferative (pre-ovulatory) phase. The study subjects were matched for age, body mass index and race. The age range was 20 to 35 years. All volunteers were evaluated in reproductive endocrinology clinic, Gynecology Division, Clinics Hospital, University of São Paulo Medical School Profile and concentration of small leucine-rich proteoglycans (decorin, lumican, fibromodulin and biglycan) were determined by immunohistochemical testing and Western blotting. Decorin
The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as biological filters and modulate growth-factor activities, regulate collagen fibrillogenesis and skin tensile strength, affect tumor cell growth and invasion, and influence corneal transparency and neurite outgrowth. Additional roles, derived from studies of mutant animals, indicate that certain proteoglycans are essential to life whereas others might be redundant. The review focuses on the most recent genetic and molecular biological studies of the matrix proteoglycans, broadly defined as proteoglycans secreted into the pericellular matrix. Special emphasis is placed on the molecular organization of the protein core, the utilization of protein modules, the gene structure and transcriptional control, and the functional roles of the various proteoglycans. ...
Versican is present throughout advanced lesions of atherosclerosis as well. A large CSPG has been isolated from atherosclerotic lesions of large hydrodynamic size with a core protein ranging in size from 160 to 245 and containing a mixture of chondroitin 6-sulfate and chondroitin 4-sulfate chains with chondroitin 6-sulfate predominating.20,35-38 Versican is prominent at the edges of the necrotic core in more advanced lesions of atherosclerosis and in close proximity to deposited lipoproteins,25,29,30 suggesting a role in the retention of lipoproteins in the vessel wall. The response to retention hypothesis of atherosclerosis,39 based on pioneering work performed in the 1970s and 1980s40-44 invokes a critical role in atherogenesis for the retention of lipoproteins by ECM proteoglycans. A number of studies have shown that versican as well as other proteoglycans such as biglycan are associated with lipoprotein deposits in human atherosclerotic lesions25,27,29,31 and in lipid induced lesions in ...
The objective of the present review is to synthesize the information on the cellular and molecular players responsible for maintaining a homeostatic balance between a naturally invasive human being placenta and the maternal uterus in pregnancy; to review the assignments of decorin (DCN) as a molecular participant in this homeostasis; to list the common diseases linked with a break-down in this homeostasis, ending from a hyper-invasive or hypo-invasive placenta, and their root systems. in this balance actively. We discuss the procedure of uterine angiogenesis in the circumstance Smoc2 of uterine arterial adjustments during regular being pregnant and preeclampsia. We evaluate and comparison trophoblast development and breach with the procedures included in tumorigenesis with particular emphasis on the assignments of DCN and increase essential queries that stay to end up being attended to. Decorin (DCN) is certainly a little leucine-rich proteoglycan created by buy 53-86-1 stromal cells, including ...
S. Xie*, B. Schurink, F. Wolbers, R. Luttge*, and G. Hassink. Nanoscaffolds stiffness affects primary cortical cell network formation. J. Vac. Sci. Technol. B. 2014, 32(6), 06FD03.. S. Xie*, R. Luttge*. Imprint lithography provides topographical nanocues to guide cell growth in primary cortical cell culture. Microelectron. Eng. 2014, 124, 30-36.. Xie, S. J.; Lu, Y. X.; Zhang, S. C.; Wang, L.D.; Zhang X.R.*. Electro-optical gas sensor based on a planar light-emitting electrochemical cell microarray, Small. 2010, 6(17), 1897-1899.. Xiaoyan Wang, Kenichi Harimoto,Sijia Xie, Hao Cheng, Jing Liu, and Zhao Wang*. Matrix Protein Biglycan Induces Osteoblast Differentiation through Extracellular Signal-Regulated Kinase and Smad Pathways. Biol. Pharm. Bull. 2010, 33(11) 1891-1897. ...
Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terrence, Getachew, Robel, Cao, Yingnan, Zheng, Wenhua, Osman, Narin and Little, Peter James (2018). Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2. The Journal of Pharmacology and Experimental Therapeutics, 365 (1), 156-164. doi: 10.1124/jpet.117.244483 ...
Expression of BGN (DSPG1, SLRR1A) in small intestine tissue. Antibody staining with HPA003157 and CAB003678 in immunohistochemistry.
Hey, Im a n00b so hopefully this is something simple that Ive missed, but: Im using a transition to return to the start of the music loop, with some long releases & reverb tails pasted in the transition timeline to s…
Three exocellular beta-1,3-glucanases from Acremonium blochii strain C59, BGN3.2, BGN3.3 and BGN3.4, were purified. Two, BGN3.2 and BGN3.4 appeared to act as exo-enzymes against laminarin from Laminaria digitata, while BGN3.3 displayed an endo-mode of action. The N-terminal amino acid sequence data for BGN3.2 and BGN3.4 suggested these two enzymes may be encoded by different genes. The gene encoding the BGN3.2 glucanase was fully sequenced, and its deduced amino acid sequence was similar to those for all other sequenced fungal exo-beta-1,3-glucanases. This BGN3.2 gene consists of an uninterrupted ORF of 2349 bp encoding 783 amino acids possibly with two cleavage sites for the potential removal of a pre- and pro-protein, respectively. A DNA fragment encoding a portion of the BGN3.4 gene was amplified by PCR, and the nucleotide sequence of this fragment confirmed that BGN3.2 and BGN3.4 are encoded by different genes. The internal peptide sequences of BGN3.3 were not present in the amino acid ...
human EPYC protein: member of the small leucine-rich repeat proteoglycan (SLRP) family; predominantly expressed in cartilage; RefSeq NM_004950
ALPL Mouse anti-Human, Clone: BGN/03/66KF44, Abnova™-Mouse monoclonal antibody raised against human ALPL. Shop ALPL Mouse anti-Human, Clone: BGN/03/66KF44, Abnova™
Following the results inside the cartilage model, we mea sured the serum amounts of BGM in an animal model of RA, an autoimmune sickness which leads to chronic inflamma tion leading to ECMR from the synovial joints. The forma tion and degradation profile of various kinds of collagen has previously Inhibitors,Modulators,Libraries been studied within the CIA model, exhibiting an increase in collagen degradation neo epitope ranges in serum with all the progression in the sickness. Consider ing the close association of biglycan with collagen, we evaluated the potential of BGM as a marker for ECMR within this model. The outcomes demonstrate a superb separation involving nutritious and diseased animals in the levels of BGM within the serum, suggesting that this proteoglycan could also be im portant in the improvement with the pathology.. To even more confirm the romance of BGM with ECMR, two animal models of liver fibrosis, the CCL4 handled rats as well as BDL rats, were investigated to examine the ...
Mouse Monoclonal Anti-Alkaline Phosphatase, Liver/Bone/Kidney Antibody (BGN/03/662). Validated: WB, ELISA. Tested Reactivity: Human, Bacteria. 100% Guaranteed.
This MATLAB function returns the LDPC-encoded output matrix for the input data matrix in and base graph number bgn, as specified in TS 38.212 Section 5.3.2 [1].
chains in the Genus database with same CATH superfamily 4B67 A; 2XVI A; 2VVL A; 1E6E A; 4EIP A; 3SFD A; 3GSI A; 1ZX9 A; 4FDC B; 4K5S A; 3IHG A; 2EQ8 A; 5EBK A; 1OJD A; 4EM4 A; 2JBV A; 1DNC A; 2YLX A; 3II4 A; 4H4S A; 3AWI A; 5M0Z A; 1YQ4 A; 4YKG A; 2XFO A; 5M10 A; 3EF6 A; 1PXC A; 1GRE A; 3P4Q A; 3AE9 A; 4U8P A; 1KNP A; 4DNA A; 4OPT A; 1RP0 A; 4FX9 A; 2R0P A; 3R9U A; 5TR3 A; 2GRT A; 1GPE A; 1KFY A; 3NT6 A; 1F8R A; 4YTM A; 2FJB A; 2YR5 A; 3K7Q X; 2ARD A; 1B8S A; 1H6V A; 2AQJ A; 1EL8 A; 4EMI A; 2GV8 A; 4GCM A; 5FS8 A; 3URH A; 4YSZ A; 1O95 A; 2NVK X; 3S61 A; 2E1M A; 1M6I A; 4K8D A; 1IUU A; 3NN6 X; 3RHA A; 2C70 A; 2XLR A; 3AE5 A; 2CVJ A; 2B7S A; 1CJ3 A; 2OA1 A; 3OZ2 A; 4OPU A; 5U25 A; 2Q0L A; 5KXJ A; 1FEC A; 4X9M A; 3P4R A; 1N4U A; 2Y6Q A; 2V3B A; 2XVF A; 2ZBW A; 3M12 A; 3NRN A; 4REK A; 1Q1R A; 3UP4 A; 3GRT A; 3NN0 X; 2BK4 A; 1KF6 A; 1REO A; 1O5W A; 1PJ7 A; 3CPH G; 4BK2 A; 1NEK A; 3AEC A; 1PBC A; 2WOV A; 1ZK7 A; 1S2Y A; 1FOH A; 3KU9 A; 3UTG A; 1K4Q A; 3VR8 A; 4GR1 A; 4A9W A; 1BGN A; 4JQ9 A; 4I58 A; ...
The Bulgarian government is planning to allocate BGN 50 M to pensioners in Easter bonuses.. This was announced by Bulgarian Prime Minister Boyko Borisov on Saturday, daily Dnevnik reports.. The bonuses will be allocated from the revenues collected in the fight against contraband.. Borisov said that the revenues collected in the fight against contraband in January exceeded the amount generated in the same month last year with nearly BGN 1 B.. Thus the prime minister has ordered to Finance Minister Vladislav Goranov to grant pensioners with BGN 50 M in Easter bonuses.. Borisov estimated that since last year nearly BGN 200 M have been allocated to pensions outside the budget.. According to private bTV station, nearly 1 300 000 pensioners will be granted an Easter bonus of BGN 40.. It is expected that the poverty line will be the criteria which will determine whether pensioners will be eligible to receive the bonus.. At the beginning of this year, the poverty line was increased to BGN 300 and it is ...
Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players in regulating the homeostasis of ECM proteins. The aim was to study the synthesis of prostacyclin and its effect on fibroblast activity and ECM production, and in particular collagen I and the collagen-associated proteoglycans biglycan and decorin. Parenchymal lung fibroblasts were isolated from lungs from COPD patients (GOLD stage IV) and from lungs and transbronchial biopsies from control subjects. The prostacyclin analog iloprost was used to study the effect of prostacyclin on ECM protein synthesis, migration, proliferation and contractile capacity of fibroblasts. TGF-β1 stimulation significantly increased prostacyclin synthesis in fibroblasts from COPD patients (p | 0.01), but showed no effect on fibroblasts from
Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players in regulating the homeostasis of ECM proteins. The aim was to study the synthesis of prostacyclin and its effect on fibroblast activity and ECM production, and in particular collagen I and the collagen-associated proteoglycans biglycan and decorin. Parenchymal lung fibroblasts were isolated from lungs from COPD patients (GOLD stage IV) and from lungs and transbronchial biopsies from control subjects. The prostacyclin analog iloprost was used to study the effect of prostacyclin on ECM protein synthesis, migration, proliferation and contractile capacity of fibroblasts. TGF-β1 stimulation significantly increased prostacyclin synthesis in fibroblasts from COPD patients (p | 0.01), but showed no effect on fibroblasts from
Synchrotron X-ray diffraction patterns were obtained from the cornea and posterior sclera of control and myopic chicks. No significant difference was found in the interfibrillar or in the intermolecular spacing of the collagen fibrils from the corneas of control and myopic chicks. The intermolecular spacing of myopic sclera was shown to be significantly (p , 0.01) higher than in controls. Sclera and cornea from normal and myopic chicks were stained for proteoglycans using the critical electrolyte method of Scott and Orford (1981). In the sclera, two morphologically distinct types of proteoglycans could be distinguished; one small and usually elongated (approximately-equal-to 20 nm), the other larger and irregularly shaped. The small proteoglycans were seen binding preferentially to the d and e bands of the collagen fibrils. Small proteoglycans were also present within the fibrils, these were usually approximately-equal-to 10 nm in diameter although sizes up to 30 nm were observed. ...
Chinese traditional massage HUA-SHAN. Balancing energy in the body by stimulating the meridians and akupresurnite points of the body.. It takes excess internal energy in the organs of the body. Strengthens the immune system.. Holistic/front and rear 50 - 60 minutes - 60 BGN. Side/rear of the body/25-30 minutes - 40 BGN.. Classic relaxing massage Art-Magic, relaxes the muscles, tendons, nervous system, relieves mental stress. Holistic/front and rear/50-60 minutes-42 BGN.. Side/rear part of the body/25-30 minutes - 30 BGN.. Massage Tired Legs . Performed on the foot in the portion of the thigh to the foot. Passage techniques are used for relief of tension to achieve a feeling of lightness in the legs.. 30-40 minutes - 35 BGN.. Massage Collar. Massage in the shoulders, neck and head. Relieves tension and stimulates the acupressure points to the head to achieve the anti-stress effect.. 25-30 minutes-32 BGN.. KARUNA AND USUI REIKI THERAPY. Reiki is a simple, natural and safe method of ...
Anti-Human Angiotensin I Antibody, clone Ang E9 (BGN/KA/4H) , Mouse Anti-Human Monoclonal Antibody validated in E (ABD10296), Abgent
Fibromodulin is a ubiquitous protein that is most prominent in articular cartilage, tendon, and ligament. The human Fibromodulin gene maps to chromosome 1q32 and encodes a 376 amino acid protein ...
Definition: Proteoglycans are a class of glycoproteins that are heavily glycosylated. They consist of a core protein with one or more covalently (...)
Adam, Marion (2011): Regulation and functional signaling of decorin in the testis in health and disease. Dissertation, LMU München: Fakultät für Biologie ...
In humans, biglycan is encoded by the BGN gene which is located on the X chromosome. The name "biglycan" was proposed in an ... Biglycan is believed to play a role in the mineralization of bone. Knock-out mice that have had the gene for biglycan ... Biglycan has been shown to interact with SGCA. Biglycan is a particularly important proteoglycan for binding to lipoprotein in ... There is also evidence that biglycan binds to TGF-beta 1. Biglycan interacts with collagen, both via the core protein and GAG ...
Seidler, Daniela (2006). "Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype ... biglycan, fibromodulin and lumican. Proteoglycans are a major component of the animal extracellular matrix, the "filler" ... the gene encoding the galactosyltransferase B4GALT7 result in a reduced substitution of the proteoglycans decorin and biglycan ...
These activities may be modulated by its direct binding to decorin and biglycan, two members of a family of small leucine-rich ... Desnoyers L, Arnott D, Pennica D (Dec 2001). "WISP-1 binds to decorin and biglycan". The Journal of Biological Chemistry. 276 ( ...
It shares significant sequence homology with biglycan and decorin. Fibromodulin participates in the assembly of the collagen ... biglycan, fibromodulin, and lumican". Kidney International. 58 (4): 1557-68. doi:10.1046/j.1523-1755.2000.00317.x. PMID ... "Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta". ...
Bowe MA, Mendis DB, Fallon JR (Feb 2000). "The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and ... "The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and is upregulated in dystrophic muscle". The ... SGCA has been shown to interact with Biglycan. GRCh38: Ensembl release 89: ENSG00000108823 - Ensembl, May 2017 GRCm38: Ensembl ...
2005). "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway". EMBO J. 24 (7): 1397-405. doi:10.1038 ...
... and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, ... McBride OW, Fisher LW, Young MF (February 1990). "Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on ... Fisher LW, Termine JD, Young MF (March 1989). "Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology ... Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. ...
"Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development". J. Cell. Physiol. 209 (2): ...
Olin KL, Potter-Perigo S, Barrett PH, Wight TN, Chait A (January 2001). "Biglycan, a vascular proteoglycan, binds differently ...
Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1". PLOS ONE. 7 (3): e33163. Bibcode:2012PLoSO... ...
"Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta". ...
"Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta". ...
1994). "Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor ...
a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". The Journal of Biological ...
1998). "Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox". J. ...
Sartipy P, Bondjers G, Hurt-Camejo E (1999). "Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of ...
Sartipy P, Bondjers G, Hurt-Camejo E (1999). "Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of ...
Reinboth B, Hanssen E, Cleary EG, Gibson MA (2002). "Molecular interactions of biglycan and decorin with elastic fiber ... components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1". J. Biol. Chem. 277 ( ...
... biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins. 38 (2): 210-25 ...
... biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Like the other SLRPs, lumican has a molecular weight of about 40 ... biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins. 38 (2): 210-25 ...
... whereas biglycan and perlecan are only found in the epidermis. It harbors many mechanoreceptors (nerve endings) that provide ...
The focus is on the small leucine-rich proteoglycans (SLRPs) biglycan (bgn), decorin (dcn), and fibromodulin (fmod), and the ...
The reduced activity of B4GALT7 is associated with a reduced substitution of the proteoglycans decorin and biglycan with ... July 2006). "Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin ... July 2006). "Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin ...
... may refer to: Biglycan, a protein coded by the BGN gene Bulgarian lev, the currency of Bulgaria by ISO 4217 code The ...
... as Nobleman Peter Tait as Gyorg Eleanor Williams as Teenage Girl Edwin Wright as Death Dealer Captain Brian Steele as Big Lycan ...
Biglycan breast cancer dataset. Published:. 10 October 2022, Version 2 , DOI: 10.17632/mprsccwxb7.2 ... Images of histological sections with and without breast cancer, using the Biglycan biomarker. ...
In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and ... Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in ... In their soluble forms, decorin and biglycan act as powerful signaling molecules. By receptor-mediated signal transduction, ... In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and ...
KHC0480 is a ready-to-use IHC kit for staining of BGN/Biglycan. The kit provides all reagents, from antigen retrieval to cover ... Biglycan is a ubiquitous component of connective tissue matrix and may act as a signaling molecule. Upregulation of biglycan ... IHCeasy BGN/Biglycan Ready-To-Use IHC Kit. BGN/Biglycan Ready-to-use reagent kit for IHC. ... Biglycan is a member of the small leucine-rich proteoglycan (SLRP) family. It consists of a core protein that containing ...
However, the function of stroma biglycan in breast cancer is still unclear. Biglycan gene analysis and its prognostic values in ... Breast cancer patients with high biglycan expression had worse distant metastasis-free survival. Furthermore, biglycan ... Knockout of biglycan in the stroma (Bgn KO) in E0771 tumor-bearing mice inhibited metastasis to the lung. Bgn KO also impaired ... We have previously shown that biglycan is secreted from tumor endothelial cells and induces tumor angiogenesis and metastasis. ...
This is an antibody designed to detect Biglycan (BGN) ; BGN Other names. biglycan preproprotein; Biglycan; biglycan; biglycan ... biglycan; Bone/cartilage proteoglycan I; PG-S1 ... Polyclonal Antibody to Biglycan (BGN) Clone. Not applicable to ...
Results: Biglycan was cleaved in vitro by MMP-9 and -12 and the 344YWEVQPATFR353 peptide (BGM) was chosen as a potential neo- ... This assay represents both a novel marker of ECM turnover and a potential new tool to elucidate biglycan role during the ... Background: The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its fragmentation is likely to be ... Conclusion: We demonstrated that the specific tissue remodeling product of MMPs-degraded biglycan, namely the neo-epitope BGM, ...
Eukaryotic expression of recombinant biglycan. J. Biol. Chem. 271: 19571-19577, 1996. PubMed: 8702651 ...
Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem ...
Appunni, S.; Anand, V.; Khandelwal, M.; Gupta, N.; Rubens, M.; Sharma, A. Small Leucine Rich Proteoglycans (decorin, biglycan ... Lumican belongs to the family of small leucine-rich proteoglycans (SLRPs) that includes decorin, biglycan, and fibromodulin, ... Identification of a new biglycan cleavage site. Arthritis Res. 2006, 8, R26. [Google Scholar] [CrossRef] [PubMed][Green Version ... Only MMP-13 is capable of efficiently cleaving fibromodulin and biglycan [22,23] and has a poor effect on lumican and decorin ...
Expression of decorin and biglycan by rabbit articular chondrocytes. Effects of cytokines and phenotypic modulation.. Biochim. ...
Crystal structure of the biglycan dimer core protein. 2id5. Crystal Structure of the Lingo-1 Ectodomain. ...
Biglycan. A Hiukka, Marcus Ståhlman, Camilla Pettersson, Malin Levin, Martin Adiels, Susann Teneberg, ES Leinonen, Lillemor ...
... and biglycan.76 Paglia et al. investigated the in vivo effects of platelet-derived growth factor BB (PDGF-BB) in a thiol- ... biglycan, fibromodulin, lumican, and perlecan.4 They account for approximately 50% of the dry weight of the NP and 20% of the ...
Biglycan is moving along--we have just given Tivorsan a $500,000 grant (thanks to everyone who contributed to that!) and MDA ... You did not mention about Biglycan. What is the progress on that? ...
Distraction resulted in gene expression up-regulation of collagen 1 (5.4-fold), collagen 2 (5.5-fold), biglycan (7.7-fold), and ... biglycan, decorin, aggrecan, fibromodulin, and osteonectin; and matrix-regulative genes, including matrix metalloproteinase-13 ...
Fine mapping of the human biglycan (BGN) gene with the Xq28 region employing a hybrid cell panel. Genomics, 13 (2), pp. 481-483 ...
D3.633.100.150.266.450.190 Biglycan D9.698.735.700.500 D12.776.395.650.875.250 D12.776.860.300.806.500 Bile Acids and Salts ...
Müller, C., Rosmark, O., Åhrman, E., Brunnström, H., Wassilew, K., Nybom, A., Michaliková, B., Larsson, H., Eriksson, L. T., Schultz, H. H., Perch, M., Malmström, J., Wigén, J., Iversen, M. & Westergren-Thorsson, G., 2021 Aug 1, In: American Journal of Pathology. 191, 8, p. 1398-1411 14 p.. Research output: Contribution to journal › Article › peer-review ...
effects only provided in incomplete Superheroes kit simulation are time biglycan, variance, substrate histone, etc. Silica ...
The role of OBs has been challenged with the analyses of mice lacking biglycan which are reported to have fewer OBs, but ...
2012-03-30T16:58:17-04:00By Ollibean,Categories: Articles, Editors Picks, General, Medical,Tags: biglycan, Brown Institute for ... When nerve meets muscle, biglycan seals the deal. ... In the absence of the protein biglycan, synapses at ...
"Biglycan Control of Immune Function during Bone Repair". Division of Bone and Mineral Diseases. John T. Milliken Department of ...
Biglycan - Preferred Concept UI. M0543332. Scope note. A small leucine-rich proteoglycan found in a variety of tissues ... 2011; BIGLYCAN was indexed under PROTEOGLYCANS and EXTRACELLULAR MATRIX PROTEINS 1989-2010. ...
Biglycan is a class I SLRP encoded by the BGN gene which promotes proliferation and differentiation in OS cells [43, 102]. A ... Biglycan regulates MG63 osteosarcoma cell growth through a LPR6/beta-catenin/IGFR-IR signaling Axis. Front Oncol. 2018;8:470. ... Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. Genomics. 1992;13(2):481-3. ... Ungefroren H, Cikos T, Krull NB, Kalthoff H. Biglycan gene promoter activity in osteosarcoma cells is regulated by cyclic AMP. ...
The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its fragmentation is likely to be associated with ... Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases ...
As HDL can alleviate atherosclerosis and other cardiovascular diseases, and certain disease states such as the metabolic syndrome feature low HDL, pharmacological inhibition of CETP is being studied as a method of improving HDL levels.[16] To be specific, in a 2004 study, the small molecular agent torcetrapib was shown to increase HDL levels, alone and with a statin, and lower LDL when co-administered with a statin.[17] Studies into cardiovascular endpoints, however, were largely disappointing. While they confirmed the change in lipid levels, most reported an increase in blood pressure, no change in atherosclerosis,[18][19] and, in a trial of a combination of torcetrapib and atorvastatin, an increase in cardiovascular events and mortality.[20]. A compound related to torcetrapib, Dalcetrapib (investigative name JTT-705/R1658), was also studied, but trials have ceased.[21] It increases HDL levels by 30%, as compared to 60% by torcetrapib.[22] Two CETP inhibitors were previously under development. ...
  • The Role of Decorin and Biglycan Signaling in Tumorigenesis" by Valentina Diehl, Lisa Sophie Huber et al. (jefferson.edu)
  • Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. (jefferson.edu)
  • In their soluble forms, decorin and biglycan act as powerful signaling molecules. (jefferson.edu)
  • In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and address potential novel therapeutic implications. (jefferson.edu)
  • and Schaefer, Liliana, "The Role of Decorin and Biglycan Signaling in Tumorigenesis" (2021). (jefferson.edu)
  • Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. (medlineplus.gov)
  • Distraction resulted in gene expression up-regulation of collagen 1 (5.4-fold), collagen 2 (5.5-fold), biglycan (7.7-fold), and decorin (3.4-fold), while expression of fibromodulin (0.16-fold), tissue-inhibitor of matrix metalloproteinase-1 (0.05-fold), and BMP-2 (0.15-fold) was decreased, as compared with 56 days compression. (nih.gov)
  • Catabolism of aggrecan, decorin and biglycan in tendon. (mdbioproducts.com)
  • The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its fragmentation is likely to be associated with collagen turnover during the pathogenesis of diseases which involve dysregulated extracellular matrix remodeling (ECMR), such as rheumatoid arthritis (RA) and liver fibrosis. (nordicbioscience.com)
  • The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its fragmentation is likely to be associated with collagen turnover during the pathogenesis of diseases which involve dysregulated ex. (biomedcentral.com)
  • Consider ing the close association of biglycan with collagen, we evaluated the potential of BGM as a marker for ECMR within this model. (ras-signal.com)
  • Biglycan is a member of the small leucine-rich proteoglycan (SLRP) family. (ptglab.com)
  • Biglycan was cleaved in vitro by MMP-9 and -12 and the 344'YWEVQPATFR'353 peptide (BGM) was chosen as a potential neo-epitope. (nordicbioscience.com)
  • Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using KHC0480 (BGN/Biglycan IHC Kit). (ptglab.com)
  • The tissue-specific chondroitin- or dermatan-sulfate glycosaminoglycan chains of biglycan are attached to amino acid residues at the N-terminus of the core protein. (ptglab.com)
  • Biglycan is a ubiquitous component of connective tissue matrix and may act as a signaling molecule. (ptglab.com)
  • a Comparison of biglycan mRNA expression was analyzed in normal mammary glands ( n = 61) and breast cancer tissue ( n = 389) using Oncomine. (biomedcentral.com)
  • We demonstrated that the specific tissue remodeling product of MMPs-degraded biglycan, namely the neo-epitope BGM, is correlated with pathological ECMR. (nordicbioscience.com)
  • This assay represents both a novel marker of ECM turnover and a potential new tool to elucidate biglycan role during the pathological processes associated with ECMR. (nordicbioscience.com)
  • Biglycan is highly expressed in tumor stroma, associated with angiogenesis gene expression and prognosis of human breast cancer patients. (biomedcentral.com)
  • b Comparison of biglycan mRNA expression was analyzed in 14 patient-matched tumor epithelium and tumor-associated stroma specimens using Oncomine. (biomedcentral.com)
  • c Kaplan-Meier analysis was used to assess breast cancer patients with high or low biglycan mRNA expression in distant metastasis-free survival (DMFS) using a Kaplan-Meier plotter tool. (biomedcentral.com)
  • Biglycan expression, earlier vascular damage and pro-atherogenic profile improvement after smoke cessation in young people. (unime.it)
  • Images of histological sections with and without breast cancer, using the Biglycan biomarker. (mendeley.com)