Biglycan: A small leucine-rich proteoglycan found in a variety of tissues including CAPILLARY ENDOTHELIUM; SKELETAL MUSCLE; CARTILAGE; BONE; and TENDONS. The protein contains two glycosaminoglycan chains and is similar in structure to DECORIN.Decorin: A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Proteoglycans: Glycoproteins which have a very high polysaccharide content.Chondroitin Sulfate Proteoglycans: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.Versicans: HYALURONAN-containing proteoglycans found in the EXTRACELLULAR MATRIX of a variety of tissues and organs. Several versican isoforms exist due to multiple ALTERNATIVE SPLICING of the versican MESSENGER RNA.Collagen Type VI: A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.Dermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)Keratan Sulfate: A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.Aggrecans: Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Chondroitin ABC Lyase: An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Chemistry, Analytic: The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)Thrombin: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.Heparin Cofactor II: A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.Fibrinopeptide A: Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Protein PrecursorsAmino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Surface Plasmon Resonance: A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Autophagy: The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.Myocardial Reperfusion Injury: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.Toll-Like Receptor 4: A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.Toll-Like Receptors: A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.Toll-Like Receptor 2: A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Growth Differentiation Factor 15: A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.Growth Differentiation Factor 9: A bone morphogenetic protein that plays an essential role in the regulation of ovarian folliculogenesis.Heart Rupture: Disease-related laceration or tearing of tissues of the heart, including the free-wall MYOCARDIUM; HEART SEPTUM; PAPILLARY MUSCLES; CHORDAE TENDINEAE; and any of the HEART VALVES. Pathological rupture usually results from myocardial infarction (HEART RUPTURE, POST-INFARCTION).Heart Rupture, Post-Infarction: Laceration or tearing of cardiac tissues appearing after MYOCARDIAL INFARCTION.Growth Differentiation Factor 5: A growth differentiation factor that plays a role in early CHONDROGENESIS and joint formation.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Cercopithecus: A genus of Old World monkeys found in Africa although some species have been introduced into the West Indies. This genus is composed of at least twenty species: C. AETHIOPS, C. ascanius, C. campbelli, C. cephus, C. denti, C. diana, C. dryas, C. erythrogaster, C. erythrotis, C. hamlyni, C. lhoesti, C. mitis, C. mona, C. neglectus, C. nictitans, C. petaurista, C. pogonias, C. preussi, C. salongo, and C. wolfi.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Erythrocebus patas: A species of the genus ERYTHROCEBUS, subfamily CERCOPITHECINAE, family CERCOPITHECIDAE. It inhabits the flat open arid country of Africa. It is also known as the patas monkey or the red monkey.Monkey Diseases: Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).Avian Sarcoma Viruses: Group of alpharetroviruses (ALPHARETROVIRUS) producing sarcomata and other tumors in chickens and other fowl and also in pigeons, ducks, and RATS.Haplorhini: A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).Transformation, Genetic: Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.

Connective tissues: matrix composition and its relevance to physical therapy. (1/269)

In the last 2 decades, the understanding of CT structure and function has increased enormously. It is now clear that the cells of the various CTs synthesize a variety of ECM components that act not only to underpin the specific biomechanical and functional properties of tissues, but also to regulate a variety of cellular functions. Importantly for the physical therapist, and as discussed above, CTs are responsive to changes in the mechanical environment, both naturally occurring and applied. The relative proportions of collagens and PGs largely determine the mechanical properties of CTs. The relationship between the fibril-forming collagens and PG concentration is reciprocal. Connective tissues designed to resist high tensile forces are high in collagen and low in total PG content (mostly dermatan sulphate PGs), whereas CTs subjected to compressive forces have a greater PG content (mostly chondroitin sulphate PGs). Hyaluronan has multiple roles and not only provides tissue hydration and facilitation of gliding and sliding movements but also forms an integral component of large PG aggregates in pressure-resisting tissues. The smaller glycoproteins help to stabilize and link collagens and PGs to the cell surface. The result is a complex interacting network of matrix molecules, which determines both the mechanical properties and the metabolic responses of tissues. Patients with CT problems affecting movement are frequently examined and treated by physical therapists. A knowledge of the CT matrix composition and its relationship to the biomechanical properties of these tissues, particularly the predictable responses to changing mechanical forces, offers an opportunity to provide a rational basis for treatments. The complexity of the interplay among the components, however, requires that further research be undertaken to determine more precisely the effects of treatments on the structure and function of CTs.  (+info)

Distinct secondary structures of the leucine-rich repeat proteoglycans decorin and biglycan. Glycosylation-dependent conformational stability. (2/269)

Biglycan and decorin have been overexpressed in eukaryotic cells and two major glycoforms isolated under native conditions: a proteoglycan substituted with glycosaminoglycan chains; and a core protein form secreted devoid of glycosaminoglycans (Hocking, A. M., Strugnell, R. A., Ramamurthy, P., and McQuillan, D. J. (1996) J. Biol. Chem. 271, 19571-19577; Ramamurthy, P., Hocking, A. M., and McQuillan, D. J. (1996) J. Biol. Chem. 271, 19578-19584). Far-UV CD spectroscopy of decorin and biglycan proteoglycans indicates that, although they are predominantly beta-sheet, biglycan has a significantly higher content of alpha-helical structure. Decorin proteoglycan and core protein are very similar, whereas the biglycan core protein exhibits closer similarity to the decorin glycoforms than to the biglycan proteoglycan form. However, enzymatic removal of the chondroitin sulfate chains from biglycan proteoglycan does not induce a shift to the core protein structure, suggesting that the final form is influenced by polysaccharide addition only during biosynthesis. Fluorescence emission spectroscopy demonstrated that the single tryptophan residue, which is at a conserved position at the C-terminal domain of both biglycan and decorin, is found in similar microenvironments. This indicates that in this specific domain the different glycoforms do exhibit apparent conservation of structure. Exposure of decorin and biglycan to 10 M urea resulted in an increase in fluorescent intensity, which indicates that the emission from tryptophan in the native state is quenched. Comparison of urea-induced protein unfolding curves provide further evidence that decorin and biglycan assume different structures in solution. Decorin proteoglycan and core protein unfold in a manner similar to a classic two-state model, in which there is a steep transition to an unfolded state between 1 and 2 M urea. The biglycan core protein also shows a similar steep transition. However, biglycan proteoglycan shows a broad unfolding transition between 1 and 6 M urea, probably indicating the presence of stable unfolding intermediates.  (+info)

Decorin is a Zn2+ metalloprotein. (3/269)

Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high affinity for Zn2+ as demonstrated by equilibrium dialyses. The Zn2+-binding sites are localized to the N-terminal domain of the core protein that contains 4 Cys residues in a spacing reminiscent of a zinc finger. A recombinant 41-amino acid long peptide representing the N-terminal domain of decorin has full Zn2+ binding activity and binds two Zn2+ ions with an average KD of 3 x 10(-7) M. Binding of Zn2+ to this peptide results in a change in secondary structure as shown by circular dichroism spectroscopy. Biglycan, a proteoglycan that is structurally closely related to decorin contains a similar high affinity Zn2+-binding segment, whereas the structurally more distantly related proteoglycans, epiphycan and osteoglycin, do not bind Zn2+ with high affinity.  (+info)

Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism. (4/269)

A bovine nasal-cartilage culture system has been utilized to analyse the catabolic events occurring in response to interleukin-1beta over a 14-day period. An early event following the start of interleukin-1 treatment was the release of glycosaminoglycan into the culture medium. This release was accompanied by the appearance in the tissue, and shortly thereafter also in the culture media, of a globular domain (G1)-containing aggrecan degradation product generated by the action of aggrecanase. Link protein was also released from the cartilage with a similar timeframe to that of the G1 fragment, although there was no evidence of its proteolytic degradation. By comparison with aggrecan, the small leucine-rich repeat proteoglycans decorin, biglycan and lumican showed a resistance to both proteolytic cleavage and release throughout the culture period. In contrast, fibromodulin exhibited a marked decrease in size after day 4, presumably due to proteolytic modification, but the major degradation product was retained throughout the culture period. Also in contrast with the early changes in the components of the proteoglycan aggregate, type II collagen did not display signs of extensive degradation until much later in the culture period. Collagen degradation products compatible with collagenase action first appeared in the medium by day 10 and increased thereafter. These data demonstrate that the leucine-rich repeat proteoglycans are resistant to proteolytic action during interleukin-1-stimulated cartilage catabolism, compared with aggrecan. This resistance and continued interaction with the surface of the collagen fibrils may help to stabilize the collagen fibrillar network and protect it from extensive proteolytic attack during the early phases of cartilage degeneration.  (+info)

Differential regulation of extracellular matrix molecules by mechanical strain of fetal lung cells. (5/269)

We have previously shown that an intermittent mechanical strain regimen (5% elongation, 60 cycles/min, 15 min/h) that simulates fetal breathing movements stimulated fetal rat lung cell proliferation. Because normal lung growth requires proper coordination between cell proliferation and extracellular matrix (ECM) remodeling, we subjected organotypic cultures of fetal rat lung cells (day 19 of gestation, term = 22 days) to this strain regimen and examined alterations in ECM gene and protein expression. Northern analysis revealed that mechanical strain reduced messages for procollagen-alpha1(I) and biglycan and increased the levels of mRNA for collagen-alpha1(IV) and -alpha2(IV), whereas laminin beta-chain mRNA levels remained constant. Regardless of mRNA changes, mechanical strain increased the protein content of type I and type IV collagen as well as of biglycan in the medium. Mechanical strain did not affect gene expression of several matrix metalloproteinases (MMPs), such as MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), and MMP-3 (stromelysin-1). Neither collagenase nor gelatinase (A and B) activities in conditioned medium were affected by mechanical strain. Tissue inhibitor of metalloproteinase activities in conditioned medium remained unchanged during the 48-h intermittent mechanical stretching. These data suggest that an intermittent mechanical strain differentially regulates gene and protein expression of ECM molecules in fetal lung cells. The observed increase in matrix accumulation appears to be mainly a result of an increased synthesis of ECM molecules and not of decreasing activity of degradative enzymes.  (+info)

The macromolecular characteristics of cartilage proteoglycans do not change when synthesis is up-regulated by link protein peptide. (6/269)

Previous studies have shown that a synthetic, unglycosylated analogue of the N-terminal peptide from link protein can function as a growth factor and up-regulate proteoglycan biosynthesis in explant cultures of normal human articular cartilage from a wide age range of subjects (McKenna et al., Arthritis Rheum. 41 (1998) 157-162). The present work further shows that link peptide increased proteoglycan synthesis by cartilage cultured in both the presence and absence of serum, suggesting that the mechanism of up-regulation may be different from that of insulin-like growth factors. The proteoglycans synthesised during stimulation with link peptide were of normal hydrodynamic size and the ratio of core protein to glycosaminoglycan side chains and the proportions of the large proteoglycan aggrecan to the small proteoglycans, decorin and biglycan, remained constant. Aggrecan molecules were equally capable of forming aggregates as those from control tissues and the relative proportions of decorin and biglycan were unchanged showing that both were co-ordinately up-regulated. These results confirmed that this novel peptide is a potent stimulator of proteoglycan synthesis by articular cartilage and showed that the newly synthesised proteoglycans were of normal composition.  (+info)

External beam radiation after stent implantation increases neointimal hyperplasia by augmenting smooth muscle cell proliferation and extracellular matrix accumulation. (7/269)

OBJECTIVES: We sought to examine the effects of high volume external beam radiation (EBR) after stent implantation on neointimal hyperplasia, smooth muscle cell (SMC) proliferation, presence of inflammatory cells and expression of extracellular matrix (ECM). BACKGROUND: Endovascular irradiation has been shown to reduce restenosis rates after angioplasty in preliminary trials, but conflicting results have been reported for the effects of external beam irradiation. METHODS: Forty-three Palmaz-Schatz stents were implanted into iliac arteries of New Zealand White rabbits. The arteries were externally irradiated after stent implantation with a single dose of 8 Gy (at day 3) or 16 Gy in two fractions (8 Gy at days 3 and 4) by means of a linear accelerator. In the control rabbits, no radiation was applied after stent implantation. Smooth muscle cells, macrophages and ECM were studied by immunohistochemistry at one and 12 weeks after stent implantation. Collagen type I and biglycan messenger ribonucleic acid (mRNA) levels were assessed by Northern blot analysis at one week. Neointimal cell densities and arterial lumen stenosis were measured by histomorphometry at 12 weeks. RESULTS: At 1 week, SMC proliferation at the site of stent implantation was increased after EBR with 8 and 16 Gy (26 +/- 5%, 32 +/- 3% vs. 17 +/- 8%; p < 0.01, 16 Gy vs. control). External beam radiation with 8 and 16 Gy augmented SMC proliferation proximal and distal to the angioplasty site (11 +/- 3%, 14 +/- 3 vs. 6 +/- 1%; p < 0.01, 16 Gy vs. control). Collagen type I and biglycan mRNA levels were elevated in stented arteries after EBR with 16 Gy. At 12 weeks, a marked decrease in neointimal cell density (248 +/- 97 vs. 498 +/- 117 SMCs/0.1 mm2 neointima; p < 0.005 vs. control) was noted after EBR with 16 Gy. Irradiation with 8 and 16 Gy increased arterial lumen stenosis compared with nonirradiated control rabbits (45 +/- 7%, 55 +/- 9% vs. 33 +/- 7%; p < 0.05, 8 Gy and p < 0.001, 16 Gy vs. control). CONCLUSIONS: High volume external beam radiation at doses of 8 or 16 Gy causes restenosis by augmenting proliferative activity at and adjacent to the site of stent implantation, and by dose-dependent up-regulation of extracellular matrix expression. The study suggests that excessive matrix accumulation is an important determinant of failure of radiation therapy to prevent restenosis.  (+info)

Cyclic expression of mRNA transcripts for connective tissue components in the mouse ovary. (8/269)

In the ovary, differentiation of germinal cells into primordial follicles, functional ovulatory follicles and corpus luteum, all take place in a connective tissue matrix. We postulated that extracellular matrix (ECM) of the ovary participates actively in ovarian functions. To test this, the mRNA levels for several ECM components were determined in the mouse ovary at six distinct stages of the 4-day oestrous cycle. Northern analysis revealed statistically significant cyclic expression patterns for the mRNAs coding for type III, IV and VI collagens as well as for the small proteoglycan, biglycan, and for syndecan-1 and osteonectin. The cyclic changes observed in the mRNAs for these structural components exceeded those for matrix metalloproteinases (MMP)-2, -9 and -13, and for tissue inhibitors of matrix metalloproteinases (TIMP)-1, -2 and -3, where the changes were not statistically significant, despite their apparent role in ECM remodelling in the ovary. These observations support the hypothesis that cyclic changes in the production and degradation of ECM are part of normal ovarian function connected with follicular maturation, rupture and corpus luteum formation.  (+info)

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene which is located on the X chromosome. The name "biglycan" was proposed in an article by Fisher, Termine and Young in an article in the Journal of Biological Chemistry in 1989 because the proteoglycan contained two GAG chains; formerly it was known as proteoglycan-I (PG-I). Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS), with DS being more abundant in most connective tissues. The CS/DS chains are attached at amino acids 5 and 10 in human biglycan. The composition of the GAG chains has been reported as varying according to tissue of origin. Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. The composition of GAG ...
Introduction:Thrombin signalling initiates inflammatory events directly and through activation of platelets. Endogenous and pharmacologic inhibitors of thrombin are therefore of relevance during atheroprogression and for therapeutic intervention. The small leucine-rich proteoglycan biglycan (BGN) is thought to inhibit thrombin activity by activation of heparin cofactor II. Hypothesis: Genetic deletion of BGN affects thrombin activity, inflammation and atherosclerosis. Methods:Male mice deficient in apolipoprotein E and BGN (ApoE-/-/Bgn-/0) were compared with their ApoE-/- littermates.. Results: In ApoE-/- mice BGN was detected in the plasma and subendothelial matrix of capillaries, arterioles and in atherosclerotic plaques. In line with a role of BGN in balancing thrombin activity, ApoE-/-/Bgn-/0 mice exhibited higher activity of circulating thrombin and greater platelet activation than did ApoE-/- mice. Furthermore, higher concentrations of circulating cytokines in ApoE-/-/Bgn-/0 mice suggested ...
article{6b8e8868-1afd-41d6-808d-4fc5532ec3af, abstract = {The ability of the leucine-rich repeat (LRR) proteins biglycan, decorin and chondroadherin to interact with collagen VI and influence its assembly to supramolecular structures was studied by electron microscopy and surface plasmon resonance measurements in the BIAcore 2000 system. Biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes. Only the intact molecule, substituted with two dermatan sulfate chains, had this capacity. Intact decorin, with one dermatan sulfate chain only, was considerably less efficient and aggregates of organized collagen VI were found only after several hours. Chondroadherin without glycosaminoglycan substitutions did not induce any ordered collagen VI organization. However, all three related LRR proteins were shown to interact with collagen VI using electron microscopy and surface plasmon resonance. Biglycan and decorin were ...
Kiss, Krisztina and Csonka, Csaba and Pálóczi, János and Pipis, Judit and Görbe, Anikó and Kocsis, Gabriella F. and Murlasits, Zsolt and Sárközy, Márta and Szűcs, Gergő and Holmes, Christopher P. and Pan, Yijun and Bhandari, Ashok and Csont, Tamás Bálint and Shamloo, Mehrdad and Woodburn, Kathryn W and Ferdinandy, Péter and Bencsik, Péter (2016) Novel, selective EPO receptor ligands lacking erythropoietic activityreduce infarct size in acute myocardial infarction in rats. PHARMACOLOGICAL RESEARCH, 13 (Pt A). pp. 62-70. ISSN 1043-6618 Gáspár, Renáta and Pipicz, Márton and Hawchar, Fatime and Kovács, Dávid and Djirackor, Luna and Görbe, Anikó and Varga, Zoltán V and Kiricsi, Mónika and Petrovski, Goran and Gácser, Attila and Csonka, Csaba and Csont, Tamás (2016) The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes. Journal of molecular and cellular cardiology, 99. pp. 138-150. ISSN 1095-8584 Kiss, Krisztina and ...
Biglycan Antibody 16409-1-AP has been identified with IF, IHC, IP, WB, ELISA. 16409-1-AP detected 40-48 kDa band in COLO 320 cells with 1:500-1:1000 dilution...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
Biglycan Preproprotein antibody, C-term (biglycan) for IHC, WB. Anti-Biglycan Preproprotein pAb (GTX89194) is tested in Human, Rat samples. 100% Ab-Assurance.
Goat polyclonal antibody raised against synthetic peptide of BGN. A synthetic peptide corresponding to C-terminus of human BGN. (PAB7149) - Products - Abnova
Affiliation:Nihon University,School of Dentistry,Research Associate,歯学部,助手, Research Field:Morphological basic dentistry, Keywords:alkaline phosphatase,biglycan,proteoglycan,BMP,TGF-β,decorin,osteoblast,biolycan,culture,osteoblasts, # of Research Projects:1, # of Research Products:0
Rabbit Polyclonal Anti-Fibromodulin/FMOD Antibody. Validated: WB. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
Sequence variants and/or copy number variants (deletions/duplications) within the BGN gene will be detected with >99% sensitivity. Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported. Benign and likely...
Looking for online definition of biglycan proteoglycan in the Medical Dictionary? biglycan proteoglycan explanation free. What is biglycan proteoglycan? Meaning of biglycan proteoglycan medical term. What does biglycan proteoglycan mean?
Decorin is a protein that in humans is encoded by the DCN gene. Decorin is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorins name is a derivative of both the fact that it "decorates" collagen type I, and that it interacts with the "d" and "e" bands of fibrils of this collagen. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal ...
Proteoglycans are macromolecules composed of a core protein and complex, linear, long-chain carbohydrates, called glycosaminoglycans (GAGs). GAGs consist of repeating disaccharide units bearing negatively charged sulfate and carboxy groups. GAGs are covalently bound to the core protein via a tetrasaccharide linkage [GlcA-Gal-Gal-Xyl]. There are distinct types of GAGs: chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS), heparin, keratan sulfate, and hyaluronan. Several classes of CS and DS containing proteoglycans are found in the artery. These include versican, a large CS containing proteoglycan, and biglycan and decorin, 2 small leucine-rich proteoglycans containing DS and CS/DS, respectively. HS containing proteoglycans, the syndecans and glypicans, are associated with the cell membrane of smooth muscle cells (SMCs) and endothelial cells. Perlecan, a ,500-kDa molecule that is the major HS in subendothelial matrix,16 is also an important component of the artery wall.. The ...
FLRT1 Full-Length MS Protein Standard (NP_037412), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain.
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|strong|Mouse anti 17-beta-Estradiol antibody, clone 4S112 (BGN/06/88112)|/strong| recognizes 17-beta estradiol, a mammalian estrogenic hormone, produced in the ovaries, placenta and testis that has a…
人Decorin ELISA试剂盒(DCN) ELISA试剂盒datasheet (ab99998).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽,使用效果保证,中国70%以上现货。
Endometrial growth and differentiation is under the influence of sex hormones such as estrogen, progesterone, and androgens. In women with PCOS there is a deficiency in cyclic progesterone production due to chronic anovulation and a relative increase in other substances, such as insulin, cytokines, and growth factors, which results in an imbalance in endometrial hemostasis in these patients, possibly leading to abnormal uterine bleeding, infertility, and an increased risk of developing endometrial hyperplasia [3, 21-25]. The specific receptors for insulin and Insulin Growth Factors (IGFs) as well as high-affinity IGF-binding proteins (IGFBPs) have been detected in endometrial tissues [26]. IGFs have proliferative effects and the secretion of these IGFBPs, which can modulate the bioavailability of IGFs by competing with the IGF receptor, is stimulated by progesterone and inhibited by insulin. Consequently the action of IGFs may be more intense in endometrial cells [6]. Moreover, both insulin and ...
Versican is present throughout advanced lesions of atherosclerosis as well. A large CSPG has been isolated from atherosclerotic lesions of large hydrodynamic size with a core protein ranging in size from 160 to 245 and containing a mixture of chondroitin 6-sulfate and chondroitin 4-sulfate chains with chondroitin 6-sulfate predominating.20,35-38 Versican is prominent at the edges of the necrotic core in more advanced lesions of atherosclerosis and in close proximity to deposited lipoproteins,25,29,30 suggesting a role in the retention of lipoproteins in the vessel wall. The response to retention hypothesis of atherosclerosis,39 based on pioneering work performed in the 1970s and 1980s40-44 invokes a critical role in atherogenesis for the retention of lipoproteins by ECM proteoglycans. A number of studies have shown that versican as well as other proteoglycans such as biglycan are associated with lipoprotein deposits in human atherosclerotic lesions25,27,29,31 and in lipid induced lesions in ...
The objective of the present review is to synthesize the information on the cellular and molecular players responsible for maintaining a homeostatic balance between a naturally invasive human being placenta and the maternal uterus in pregnancy; to review the assignments of decorin (DCN) as a molecular participant in this homeostasis; to list the common diseases linked with a break-down in this homeostasis, ending from a hyper-invasive or hypo-invasive placenta, and their root systems. in this balance actively. We discuss the procedure of uterine angiogenesis in the circumstance Smoc2 of uterine arterial adjustments during regular being pregnant and preeclampsia. We evaluate and comparison trophoblast development and breach with the procedures included in tumorigenesis with particular emphasis on the assignments of DCN and increase essential queries that stay to end up being attended to. Decorin (DCN) is certainly a little leucine-rich proteoglycan created by buy 53-86-1 stromal cells, including ...
S. Xie*, B. Schurink, F. Wolbers, R. Luttge*, and G. Hassink. Nanoscaffolds stiffness affects primary cortical cell network formation. J. Vac. Sci. Technol. B. 2014, 32(6), 06FD03.. S. Xie*, R. Luttge*. Imprint lithography provides topographical nanocues to guide cell growth in primary cortical cell culture. Microelectron. Eng. 2014, 124, 30-36.. Xie, S. J.; Lu, Y. X.; Zhang, S. C.; Wang, L.D.; Zhang X.R.*. Electro-optical gas sensor based on a planar light-emitting electrochemical cell microarray, Small. 2010, 6(17), 1897-1899.. Xiaoyan Wang, Kenichi Harimoto,Sijia Xie, Hao Cheng, Jing Liu, and Zhao Wang*. Matrix Protein Biglycan Induces Osteoblast Differentiation through Extracellular Signal-Regulated Kinase and Smad Pathways. Biol. Pharm. Bull. 2010, 33(11) 1891-1897. ...
Expression of BGN (DSPG1, SLRR1A) in small intestine tissue. Antibody staining with HPA003157 and CAB003678 in immunohistochemistry.
Three exocellular beta-1,3-glucanases from Acremonium blochii strain C59, BGN3.2, BGN3.3 and BGN3.4, were purified. Two, BGN3.2 and BGN3.4 appeared to act as exo-enzymes against laminarin from Laminaria digitata, while BGN3.3 displayed an endo-mode of action. The N-terminal amino acid sequence data for BGN3.2 and BGN3.4 suggested these two enzymes may be encoded by different genes. The gene encoding the BGN3.2 glucanase was fully sequenced, and its deduced amino acid sequence was similar to those for all other sequenced fungal exo-beta-1,3-glucanases. This BGN3.2 gene consists of an uninterrupted ORF of 2349 bp encoding 783 amino acids possibly with two cleavage sites for the potential removal of a pre- and pro-protein, respectively. A DNA fragment encoding a portion of the BGN3.4 gene was amplified by PCR, and the nucleotide sequence of this fragment confirmed that BGN3.2 and BGN3.4 are encoded by different genes. The internal peptide sequences of BGN3.3 were not present in the amino acid ...
human EPYC protein: member of the small leucine-rich repeat proteoglycan (SLRP) family; predominantly expressed in cartilage; RefSeq NM_004950
Mouse Monoclonal Anti-Alkaline Phosphatase, Liver/Bone/Kidney Antibody (BGN/03/662). Validated: WB, ELISA. Tested Reactivity: Human, Bacteria. 100% Guaranteed.
This MATLAB function returns the LDPC-encoded output matrix for the input data matrix in and base graph number bgn, as specified in TS 38.212 Section 5.3.2 [1].
Synchrotron X-ray diffraction patterns were obtained from the cornea and posterior sclera of control and myopic chicks. No significant difference was found in the interfibrillar or in the intermolecular spacing of the collagen fibrils from the corneas of control and myopic chicks. The intermolecular spacing of myopic sclera was shown to be significantly (p , 0.01) higher than in controls. Sclera and cornea from normal and myopic chicks were stained for proteoglycans using the critical electrolyte method of Scott and Orford (1981). In the sclera, two morphologically distinct types of proteoglycans could be distinguished; one small and usually elongated (approximately-equal-to 20 nm), the other larger and irregularly shaped. The small proteoglycans were seen binding preferentially to the d and e bands of the collagen fibrils. Small proteoglycans were also present within the fibrils, these were usually approximately-equal-to 10 nm in diameter although sizes up to 30 nm were observed. ...
Chinese traditional massage "HUA-SHAN". Balancing energy in the body by stimulating the meridians and akupresurnite points of the body.. It takes excess internal energy in the organs of the body. Strengthens the immune system.. Holistic/front and rear 50 - 60 minutes - 60 BGN. Side/rear of the body/25-30 minutes - 40 BGN.. Classic relaxing massage "Art-Magic", relaxes the muscles, tendons, nervous system, relieves mental stress. Holistic/front and rear/50-60 minutes-42 BGN.. Side/rear part of the body/25-30 minutes - 30 BGN.. Massage "Tired Legs ". Performed on the foot in the portion of the thigh to the foot. Passage techniques are used for relief of tension to achieve a feeling of lightness in the legs.. 30-40 minutes - 35 BGN.. Massage "Collar". Massage in the shoulders, neck and head. Relieves tension and stimulates the acupressure points to the head to achieve the anti-stress effect.. 25-30 minutes-32 BGN.. KARUNA AND USUI REIKI THERAPY. Reiki is a simple, natural and safe method of ...
Definition: Proteoglycans are a class of glycoproteins that are heavily glycosylated. They consist of a core protein with one or more covalently (...)
Adam, Marion (2011): Regulation and functional signaling of decorin in the testis in health and disease. Dissertation, LMU München: Fakultät für Biologie ...
then,selama aku kawin aku baru sekali masak kat umah PIL...goreng bihun..hubby pun igt lagi..masa baru2 kawin...pas pada tu aku hanya akan masuk dapur utk mkn or wat air panas..tu jer..n tolong2 basuh pinggan, kemas2...pas tu masa aku kat sana aku selalu rase mengantuk..asyik tido jer...korang bayangkan, bgn tdo pun lewat..bila MIL kejut subuh aku berat sgt nak bgn...bgn tdo kdg2 kul 9 lbh mcm tu..klau tak kat umah aku sendiri or umah mak aku xdenye aku bgn selewat tue...pas sarapan pagi dlm kul 11 lbh cam tu aku naik bilik utk sambung tdo..bgn time zohor,mandi solat then turun makan tghr...pas tu dlm kul 3 lbh ke aku naik bilik semula tdo lg smpai ke ptg..klau tdo ngn hubby lagi lar aku lwt bgn ...
Several ECM proteins, such as fibronectin, hyaluronan-derived oligosaccharides, lumican, and biglycan, are now recognized as endogenous ligands of the pattern recognition receptors.6,33,34 A previous study has shown that matrilin 2 activates proinflammatory signaling pathways in macrophages via TLRs.9 In this study, we found increased expression of both TLR4 and TLR2 in normal human VICs after matrilin 2 stimulation. The potency of matrilin 2 for the induction of α-SMA, collagen I, Runx2, and ALP expression is attenuated by knockdown of TLR4 or TLR2. These observations suggest that both TLR2 and TLR4 are involved in mediating the responses to matrilin 2. It is possible that TLR2 and TLR4 interact. Namely, TLR2 activation affects TLR4 activity and verse versa. Alternatively, these 2 innate immune receptors may dimerize or synergize in response to matrilin 2 stimulation. In this regard, interaction between TLR2 and TLR4 has been reported.35 Nevertheless, matrilin 2 induces phenotypic transition ...
In the present investigation we show that CHAD, a relatively abundant noncollagenous protein in cartilage extracellular matrix, interacts with β1 integrins on bovine chondrocytes. This interesting finding identifies CHAD as a candidate for mediating signals between the chondrocytes and the cartilage matrix.. CHAD is a member of the LRR protein family (35). Among other members in this family are the small cartilage proteoglycans biglycan, decorin, fibromodulin, and lumican. These proteoglycans are all known to interact with collagen (18, 41, 47), but it is not known if CHAD interacts with collagen or other matrix molecules.. Chondrocyte adhesion to CHAD was partially inhibited by a rat polyclonal antibody against β1 integrin. Species differences between cells and antibodies may explain why the inhibition was not total. Alternatively, other receptors than β1 integrins may also be involved in the adhesion to CHAD. We found that adhesion of chondrocytes to CHAD was dependent on Mg2+ or Mn2+ but ...
Confirmation of Differential Expression between Classes on Independent Tumor Samples. We have generated a genetic fingerprint of chemotherapy-resistant tumors ( Fig. 1). A selection of these genes involved in osteoclastogenesis and ECM remodeling was validated via quantitative RT-PCR on an independent tumor sample set (Huvos I/II n = 3; Huvos III/IV n = 3). Quantitative RT-PCR validation was conducted on desmoplakin, OPG, plasminogen activator inhibitor type 1, biglycan, annexin 2, PLA2G2A, and SPARC-like 1. The microarray expression differences of these genes were confirmed in this independent sample set ( Table 2). This quantitative RT-PCR validation verifies the proposed dysregulation of osteoclastogenesis and ECM modulating genes in poor-prognosis samples.. To further confirm that the significant genes identified in the microarray data were indeed biologically significant, we investigated whether this gene list ( Fig. 1) was able to segregate osteosarcoma tumors characterized by aggressive ...
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Buy our Recombinant human Decorin protein. Ab169898 is an active full length protein produced in Escherichia coli and has been validated in FuncS, SDS-PAGE…
My MIL pon mcm kurg percaya anak dia leh jg baby.heh.Tapi saya percaya suami saya.Dari anta nursery kan.Ntah2 takde org syg pon kat anak saya kat situ :-P Tapi masa mula2 dulu pon azwan mmg susah nak bgn malam buat susu.Susah nak sedar dr tido kalau Rayna nangis.Tapi btol la org kata,masa bole merubah segalanya ...
The TLR family is a large family of receptors, with at least 11 members that have been identified thus far [24]. The TLRs play an important role in the host defense mechanism as part of the innate immune response. The different members of the TLR family have evolved to recognize pathogen-associated molecular patterns (PAMPs), including cell wall components of Gram-positive, Gram-negative bacteria, viruses and fungi [24]. TLRs are also stimulated by damage-associated molecular patterns (DAMPs). DAMPs are host-derived proteins including extracellular matrix components, and macromolecule fragments that are released due to tissue injury and cell death and can activate the TLRs [25]. Examples of DAMPs that were shown to activate TLRs, specifically TLR2 or TLR4, in the joint environment include biglycan, high mobility group box 1 protein (HMGB1), glycoprotein 96 (gp96), fibronectin, low molecular weight hyaluronan fragments, and an aggrecan fragment among others [26-32]. Binding of DAMPs to TLR2 or ...
Cells of the meniscus are exposed to a wide range of time-varying mechanical stimuli that may regulate their metabolic activity in vivo. In this study, the biological response of the meniscus to compressive stimuli was evaluated in vitro, using a well-controlled explant culture system. Gene expression for relevant extracellular matrix proteins was quantified using real-time RT-PCR following a 24 h period of applied static (0.1 MPa compressive stress) or dynamic compression (0.08-0.16 MPa). Static and dynamic compression were found to differentially regulate mRNA levels for specific proteins of the extracellular matrix. Decreased mRNA levels were observed for decorin ( [similar to] 2.1 fold-difference) and type II collagen ( [similar to] 4.0 fold-difference) following 24 h of dynamic compression. Decorin mRNA levels also decreased following static compression ( [similar to] 4.5 fold-difference), as did mRNA levels for both types I ( [similar to] 3.3 fold-difference) and II collagen ( [similar to] ...
The U.S. Board on Geographic Names (BGN) is a Federal body created in 1890 and established in its present form by Public Law in 1947 to maintain uniform geographic name usage throughout the Federal Government. The BGN comprises representatives of Federal agencies concerned with geographic information, population, ecology, and management of public lands. Sharing its responsibilities with the Secretary of the Interior, the BGN promulgates official geographic feature names with locative attributes as well as principles, policies, and procedures governing the use of domestic names, foreign names, Antarctic names, and undersea feature names.. The original program of names standardization addressed the complex issues of domestic geographic feature names during the surge of exploration, mining, and settlement of western territories after the American Civil War. Inconsistencies and contradictions among many names, spellings, and applications became a serious problem to surveyors, map makers, and ...
... biglycan, fibromodulin and lumican. Proteoglycans are a major component of the animal extracellular matrix, the "filler" ...
These activities may be modulated by its direct binding to decorin and biglycan, two members of a family of small leucine-rich ... Desnoyers L, Arnott D, Pennica D (Dec 2001). "WISP-1 binds to decorin and biglycan". The Journal of Biological Chemistry. 276 ( ...
It shares significant sequence homology with biglycan and decorin. Fibromodulin participates in the assembly of the collagen ... biglycan, fibromodulin, and lumican". Kidney International. 58 (4): 1557-68. doi:10.1046/j.1523-1755.2000.00317.x. PMID ... "Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta". ...
Bowe MA, Mendis DB, Fallon JR (Feb 2000). "The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and ... "The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and is upregulated in dystrophic muscle". The ... SGCA has been shown to interact with Biglycan. GRCh38: Ensembl release 89: ENSG00000108823 - Ensembl, May 2017 GRCm38: Ensembl ...
2005). "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway". EMBO J. 24 (7): 1397-405. doi:10.1038 ...
... and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, ... McBride OW, Fisher LW, Young MF (Feb 1990). "Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on human ... Fisher LW, Termine JD, Young MF (Mar 1989). "Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology ... Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. ...
"Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development". J. Cell. Physiol. 209 (2): ...
2001). "Biglycan, a vascular proteoglycan, binds differently to HDL2 and HDL3: role of apoE". Arterioscler. Thromb. Vasc. Biol ...
"Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta" ...
1994). "Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor ...
a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". The Journal of Biological ...
1998). "Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox". J. ...
Sartipy P, Bondjers G, Hurt-Camejo E (1999). "Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of ...
Reinboth B, Hanssen E, Cleary EG, Gibson MA (2002). "Molecular interactions of biglycan and decorin with elastic fiber ... components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1". J. Biol. Chem. 277 ( ...
... is a proteoglycan Class II member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan ... biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins. 38 (2): 210-25 ...
... biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins. 38 (2): 210-25 ...
... whereas biglycan and perlecan are only found in the epidermis. It harbors many mechanoreceptors (nerve endings) that provide ...
2007). "Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin ...
... may refer to: Biglycan, protein coded by the BGN gene BGN, ISO 4217 currency code of the Bulgarian lev, the currency of ...
In humans, biglycan is encoded by the BGN gene which is located on the X chromosome. The name "biglycan" was proposed in an ... Biglycan is believed to play a role in the mineralization of bone. Knock-out mice that have had the gene for biglycan ... Biglycan has been shown to interact with SGCA. Biglycan is a particularly important proteoglycan for binding to lipoprotein in ... There is also evidence that biglycan binds to TGF-beta 1. Biglycan interacts with collagen, both via the core protein and GAG ...
The peptidoglycan monomers are synthesized in the cytosol and are then attached to a membrane carrier bactoprenol. Bactoprenol transports peptidoglycan monomers across the cell membrane where they are inserted into the existing peptidoglycan.[6] In the first step of peptidoglycan synthesis, glutamine, which is an amino acid, donates an amino group to a sugar, fructose 6-phosphate. This turns fructose 6-phosphate into glucosamine-6-phosphate. In step two, an acetyl group is transferred from acetyl CoA to the amino group on the glucosamine-6-phosphate creating N-acetyl-glucosamine-6-phosphate.[7] In step three of the synthesis process, the N-acetyl-glucosamine-6-phosphate is isomerized, which will change N-acetyl-glucosamine-6-phosphate to N-acetyl-glucosamine-1-phosphate.[7] In step 4, the N-acetyl-glucosamine-1-phosphate, which is now a monophosphate, attacks UTP. Uridine triphosphate, which is a pyrimidine nucleotide, has the ability to act as an energy source. In this particular reaction, ...
... s (/ˈmjuːsɪn/) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals.[1] Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers.[1] They often take an inhibitory role.[1] Some mucins are associated with controlling mineralization, including nacre formation in mollusks,[2] calcification in echinoderms[3] and bone formation in vertebrates.[4] They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer.[5] Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva. ...
... (ORM) or alpha-1-acid glycoprotein (α1AGp,[1] AGP or AAG) is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6-1.2 mg/mL (1-3% plasma protein).[2] Plasma levels are affected by pregnancy, burns, certain drugs, and certain diseases, particularly HIV.[2] The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic (positively charged) drugs (whereas albumin carries acidic (negatively charged) and neutral drugs), steroids, and protease inhibitors.[2][3] Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid glycoprotein. The effect of these changes on drug protein binding and drug delivery, however, appear to be minimal.[4] AGP shows a complex interaction with thyroid ...
... s are proteins which contain oligosaccharide chains (glycans) covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. Secreted extracellular proteins are often glycosylated. In proteins that have segments extending extracellularly, the extracellular segments are also often glycosylated. Glycoproteins are also often important integral membrane proteins, where they play a role in cell-cell interactions. It is important[according to whom?] to distinguish endoplasmic reticulum-based glycosylation of the secretory system from reversible cytosolic-nuclear glycosylation. Glycoproteins of the cytosol and nucleus can be modified through the reversible addition of a single GlcNAc residue that is considered reciprocal to phosphorylation and the functions of these are likely to be additional regulatory mechanism that controls phosphorylation-based signalling.[2] In ...
4-1BB is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily, expressed on activated T Lymphocytes.[1] 4-1BBL (4-1BB ligand) is found on APCs (antigen presenting cells) and binds to 4-1BB. ...
... is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival. All these biological properties are essential to the physiological activities of normal cells, but they are also associated with the pathologic activities of cancer cells. Experiments in animals have shown that targeting of CD44 by antibodies, antisense oligonucleotides, and CD44-soluble proteins markedly reduces the malignant activities of various neoplasms, stressing the therapeutic potential of anti-CD44 agents. High levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia.[24] Furthermore, because alternative splicing and posttranslational modifications generate many different CD44 sequences, including, perhaps, tumor-specific ...
In humans, biglycan is encoded by the BGN gene which is located on the X chromosome. The name "biglycan" was proposed in an ... Biglycan is believed to play a role in the mineralization of bone. Knock-out mice that have had the gene for biglycan ... Biglycan has been shown to interact with SGCA. Biglycan is a particularly important proteoglycan for binding to lipoprotein in ... There is also evidence that biglycan binds to TGF-beta 1. Biglycan interacts with collagen, both via the core protein and GAG ...
Rabbit polyclonal Biglycan antibody. Validated in WB, IHC and tested in Human, Pig. Immunogen corresponding to recombinant ... Anti-Biglycan antibody (ab231297) at 2 µg/ml + Recombinant human Biglycan protein. Predicted band size: 42 kDa. ... Primary - Rabbit Anti-Biglycan antibody (ab231297) IHC-P, WB Secondary - Goat Anti-Rabbit IgG H&L (HRP) (ab205718) IHC-P, WB, ... All lanes : Anti-Biglycan antibody (ab231297) at 5 µg/ml. Lane 1 : Pig spleen lysate. Lane 2 : Pig kidney lysate. Secondary. ...
Biglycan protein contains a core antigen that consists of leucine-rich repeat domains and 2 GAG chains comprising of CS/DS ...
What is Biglycan? Meaning of Biglycan as a finance term. What does Biglycan mean in finance? ... Definition of Biglycan in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... redirected from Biglycan). Also found in: Medical, Wikipedia. BGN. The current ISO 4217 currency code for Bulgarian Lev. ... Moreover, biglycan, a kind of leucine-rich repeat proteoglycan, can also activate NLRP3 inflammasomes through interaction with ...
Biglycan-null mice have a considerable survival benefit in LPS- or zymosan-induced sepsis due to lower levels of circulating ... Thus, biglycan, upon release from the ECM or from macrophages, can boost inflammation by signaling through TLR4 and TLR2, ... Biglycan, a small leucine-rich proteoglycan, is a ubiquitous ECM component; however, its biological role has not been ... The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. ...
Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway. EMBO J. 2005. 24:1397-1405. View this article ... Decorin, biglycan and their endocytosis receptor in rat renal cortex. Kidney Int. 1998. 54:1529-1541. View this article via: ... Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells. J. Biol. Chem. 2003. 278: ... Haemopoietic biglycan produced by brain cells stimulates growth of microglial cells. J. Neuroimmunol. 2000. 106:78-86. View ...
The small leucine-rich proteoglycan biglycan (BGN) is thought to inhibit thrombin activity by activation of heparin cofactor II ... Abstract 12495: Enhanced Thrombin Activity in Biglycan-deficient Mice Promotes Vascular Inflammation in Murine Atherosclerosis ... Abstract 12495: Enhanced Thrombin Activity in Biglycan-deficient Mice Promotes Vascular Inflammation in Murine Atherosclerosis ... Abstract 12495: Enhanced Thrombin Activity in Biglycan-deficient Mice Promotes Vascular Inflammation in Murine Atherosclerosis ...
... biglycan) for IHC, WB. Anti-Biglycan Preproprotein pAb (GTX89194) is tested in Human, Rat samples. 100% Ab-Assurance. ... Storage Conditions: Biglycan Preproprotein antibody, C-term. Storage Buffer. Tris saline, 0.02% sodium azide, pH7.3 with 0.5% ... Biglycan Preproprotein, SLRR1A, BGN, small leucinerich protein 1A, dermatan sulphate proteoglycan I, PG-S1, small leucine-rich ... protein 1A, biglycan, bone/cartilage proteoglycan-I, PGS1, bone/cartilage proteoglycanI, small leucinerich protein1A, DSPG1, ...
... Wiberg, Charlotte; Heinegård, Dick ... Biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a ... Biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a ... Biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a ...
Biglycan antibody LS-C156806 is an unconjugated rabbit polyclonal antibody to human Biglycan (BGN). Validated for Flow, IHC and ... Biglycan antibody LS-C156806 is an unconjugated rabbit polyclonal antibody to human Biglycan (BGN). Validated for Flow, IHC and ...
Biglycan Antibody 16409-1-AP has been identified with IF, IHC, IP, WB, ELISA. 16409-1-AP detected 40-48 kDa band in COLO 320 ... pig cartilage tissue were subjected to SDS PAGE followed by western blot with 16409-1-AP( Biglycan Antibody) at dilution of 1: ... IP Result of anti-Biglycan (IP:16409-1-AP, 4ug; Detection:16409-1-AP 1:300) with mouse skeletal muscle tissue lysate 2200ug. ... IP Result of anti-Biglycan (IP:16409-1-AP, 4ug; Detection:16409-1-AP 1:300) with mouse skeletal muscle tissue lysate 2200ug. ...
Here we show that collagen fibrils in tendons from mice deficient in biglycan and/or fibromodulin are structurally and ... Here we show that collagen fibrils in tendons from mice deficient in biglycan and/or fibromodulin are structurally and ... Here we show that collagen fibrils in tendons from mice deficient in biglycan and/or fibromodulin are structurally and ... In vivo interactions of biglycan and fibromodulin, two SLRPs highly expressed in tendons and bones, were investigated by ...
... ... Biglycan, a small leucine-rich proteoglycan, acts as a danger signal and is classically thought to promote macrophage ... The biglycan-CD44 interaction increased M1 autophagy and the number of renal M2 macrophages and reduced tubular damage ... Soluble biglycan also promoted autophagy in human peripheral blood macrophages. Using macrophages from mice lacking TLR2 and/or ...
What is biglycan proteoglycan? Meaning of biglycan proteoglycan medical term. What does biglycan proteoglycan mean? ... Looking for online definition of biglycan proteoglycan in the Medical Dictionary? biglycan proteoglycan explanation free. ... redirected from biglycan proteoglycan). Also found in: Financial. BGN. A gene on chromosome Xq28 that encodes biglycan, a ... Biglycan proteoglycan , definition of biglycan proteoglycan by Medical dictionary https://medical-dictionary.thefreedictionary. ...
Upregulation of biglycan expression in dystrophic muscle. Frozen sections of normal (wt) and mdx muscle from 6-wk-old mice were ... Biglycan is localized around the periphery of the muscle fiber and at all synapses. Further, biglycan is enriched at a subset ... Biglycan is localized around the periphery of the muscle fiber and at all synapses. Further, biglycan is enriched at a subset ... In muscle, biglycan is detected at both synaptic and nonsynaptic regions. Finally, biglycan expression is elevated in muscle ...
We found five individuals with loss-of-function mutations in BGN encoding the small leucine-rich proteoglycan biglycan. The ... Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype.. *Ariane Melchior-Becker, ... Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and ... Decreased body fat, elevated plasma transforming growth factor-β levels, and impaired BMP4-like signaling in biglycan-deficient ...
Biglycan bindsMuSKand the levels of this receptor tyrosine kinase are selectively reduced at bgn -/o synapses. In bgn -/o ... Biglycan is an extracellular MuSK binding protein important for synapse stability. Journal of Neuroscience. 2012 Feb 15;32(7): ... Biglycan is an extracellular MuSK binding protein important for synapse stability. Alison R. Amenta, Hilliary E. Creely, Mary ... Biglycan is an extracellular MuSK binding protein important for synapse stability. / Amenta, Alison R.; Creely, Hilliary E.; ...
Biglycan weakly accumulated in amyloid deposits, and both decorin and biglycan weakly stained mesangial nodules in cases of ... Biglycan, but not decorin, accumulated in the neointima of arteriosclerotic blood vessels. Decorin and biglycan mRNA synthesis ... Decorin and biglycan mRNA synthesis was evaluated by in situ hybridization. RESULTS Decorin and biglycan protein were not ... METHODS Decorin, biglycan, and collagen type I were localized immunohistochemically in human renal biopsy cases of amyloidosis ...
The Role of Biglycan in Reproduction Lechner, Beatrice Elizabeth Women and Infants Hospital-Rhode Island, Providence, RI, ... The Role of Biglycan in Reproduction. Lechner, Beatrice Elizabeth / Women and Infants Hospital-Rhode Island. $108,000. ... The Role of Biglycan in Reproduction. Lechner, Beatrice Elizabeth / Women and Infants Hospital-Rhode Island. $108,000. ... The Role of Biglycan in Reproduction. Lechner, Beatrice Elizabeth / Women and Infants Hospital-Rhode Island. $108,000. ...
biglycan, atherosclerosis, instable angina, MMP inhibitors, cytoprotection, myocardial infarction, microRNA, miRNA, I/R injury ... Biglycan™ therapy: open for out-licensing and/or co-development partnership. Use of biglycan or enhancers of biglycan activity ... The present invention relates to the use of biglycan or enhancers of biglycan activity in the preparation of pharmaceutical ... biglycan and glycantherapy are trademarks of Pharmahungary, please see www.biglycan.com ...
Biglycan, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... View all 5 R&D Systems BGN (Biglycan) Products. *View all R&D Systems BGN (Biglycan) Proteins and Enzymes*Recombinant Human ... genomics-online: gRNA clones - Search for available Biglycan gRNA products * Overview of 146 available Biglycan gene related ... genomics-online: shRNA clones - Search for available Biglycan shRNA products * Overview of 146 available Biglycan gene related ...
Novus offers a wide variety of proteins and peptides including full-length recombinant proteins that have been tested for biological activity.
Defects in the core proteins of DS-PGs such as decorin and biglycan cause congenital stromal dystrophy of the cornea, ... Defects in the core proteins of DS-PGs such as decorin and biglycan cause congenital stromal dystrophy of the cornea, ... Keywords: biglycan; carbohydrate sulfotransferase 14; decorin; chondroitin sulfate; dermatan sulfate; dermatan sulfate ... biglycan; carbohydrate sulfotransferase 14; decorin; chondroitin sulfate; dermatan sulfate; dermatan sulfate epimerase; ...
Pathogenic Participation of MuSK-Biglycan Linkage Contributive to Synaptic Stability and Signalings in Myasthenia Gravis, ... Although biglycan is not directly targeted by autoantibodies in the NMJ as is suggested above, it is of note that biglycan ... Focusing Biglycan and Muscle-Specific Tyrosine Kinase (MuSK) from the Biological and Immunological Points of View. Biglycan, ... On the other hand, skeletal muscle and bone pathologies are renovated by biglycan. We must see both faces of biglycan from the ...
Analysis of biglycan mRNA and protein levels indicated that P. gingivalis LPS significantly delayed the normally high ... This study suggests that P. gingivalis LPS influences the expression and processing of decorin and biglycan in the matrix, ... Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: Consequences for bone repair during ... Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: Consequences for bone repair during ...
  • Biglycan is believed to play a role in the mineralization of bone. (wikipedia.org)
  • Knock-out mice that have had the gene for biglycan suppressed (Bgn -/-) have an osteoporosis-like phenotype with reduced growth rate and lower bone mass than mice that can express biglycan. (wikipedia.org)
  • We also briefly discuss about biglycan as a molecule regulating the multifunctional proinflammatory signaling and also participating in the MG thymus pathology (hyperplastic change) on one hand, and a molecule to counter the pathologies in skeletal muscle and bone formation on the other hand. (imedpub.com)
  • Additonally discussed is that biglycan acts as a proinflammatory stimulus when it is in a soluble form, and also plays a role in hyperplastic change of MG thymus in which biglycan is produced from myoid cells, whereas biglycan has a beneficial effect on dystrophic muscles and bone formation. (imedpub.com)
  • In vivo, transient overexpression of circulating biglycan at the onset of renal ischemia/reperfusion injury (IRI) enhanced M1 macrophage recruitment into the kidneys of Cd44+/+ and Cd44−/− mice but not Cd14−/− mice. (fraunhofer.de)
  • Her fellowship research, which was supported by the NICHD Pediatric Scientist Development Program, was focused on the function of biglycan in muscle during development. (grantome.com)
  • Recombinant fragment (His-tag) corresponding to Human Biglycan aa 230-366. (abcam.com)
  • Biglycan binding to alpha-dystroglycan was confirmed by coimmunoprecipitation with both native and recombinant alpha-dystroglycan. (nih.gov)
  • Point out that this study suggests that treatment with recombinant human biglycan may be a way to bypass and substitute the homolog utrophin for dystrophin as a potential therapy for the disease. (medpagetoday.com)
  • Treatment with recombinant human biglycan was associated with a 50% reduction in abnormal muscle fibers characteristic of Duchenne muscular dystrophy, investigators reported online in PNAS Proceedings of the National Academy of Sciences . (medpagetoday.com)
  • Our results show that a single systemic injection of recombinant human biglycan is active for a strikingly long period," Justin R. Fallon, PhD, of Brown University in Providence, R.I., and co-authors wrote in the discussion of their findings. (medpagetoday.com)
  • The long-acting properties of systemically delivered recombinant human biglycan in mice suggest that this therapeutic strategy could be practical for use in humans, where treatment will likely be required for years," they added. (medpagetoday.com)
  • In preliminary studies, the authors showed that utrophin expression is reduced in immature muscle in the absence of biglycan and is upregulated in cultured muscle cells following the introduction of recombinant human biglycan. (medpagetoday.com)
  • They then showed that recombinant human biglycan upregulates utrophin in muscle from dystrophin-deficient mice. (medpagetoday.com)
  • The authors found that the proportion of centrally nucleated fibers decreased from 17.7% in vehicle-treated mice to 9.6% in animals treated with recombinant human biglycan ( P =0.028). (medpagetoday.com)
  • Other experiments showed that recombinant human biglycan had no effect on muscle pathology in utrophin-deficient mice, indicating that utrophin is necessary for the therapeutic action of biglycan. (medpagetoday.com)
  • The authors assessed muscle physiology in dystrophin-deficient mice treated for 15 weeks with recombinant human biglycan or vehicle. (medpagetoday.com)
  • The authors reported no adverse effects associated with administration of recombinant human biglycan, including no evidence of kidney or liver dysfunction and no changes in levels of serum creatinine, blood urea nitrogen, aspartate transaminase, or bilirubin. (medpagetoday.com)
  • LifeCell provided the recombinant human biglycan for the studies. (medpagetoday.com)
  • Biglycan-null mice have a considerable survival benefit in LPS- or zymosan-induced sepsis due to lower levels of circulating TNF-α and reduced infiltration of mononuclear cells in the lung, which cause less end-organ damage. (jci.org)
  • We found a marked increase in the number of autophagic macrophages in mice stably overexpressing soluble biglycan. (fraunhofer.de)
  • Decreased body fat, elevated plasma transforming growth factor-β levels, and impaired BMP4-like signaling in biglycan-deficient mice. (semanticscholar.org)
  • Overexpression of biglycan is anti-atherosclerotic and induces cardioprotective genes: eNOS, nNOS, iNOS, Pyk2 in the mice heart in vivo (Bereczki et al, J Proteome Res , 2007 ). (pharmahungary.com)
  • Borrelia burgdorferi Infection in Biglycan Knockout Mice. (nih.gov)
  • In muscle, biglycan is detected at both synaptic and nonsynaptic regions. (nih.gov)
  • 1993). Since we purified biglycan from synaptic membranes, we asked whether it is also expressed at the neuromuscular junction. (nih.gov)
  • Synaptic development in fetal and early postnatal biglycan null (bgn -/o ) muscle is indistinguishable from wild-type controls. (elsevier.com)
  • As one of the extracellular matrix protains, the glycosaminoglycan-binding form of biglycan is concerned with a linkage to the actin cytoskeleton and thereby contributes to synaptic stability. (imedpub.com)
  • However, taking the linkage of biglycan with MuSK into consideration, the MuSK antibodies in MG may cause an impairment in the synaptic stability based on the MuSK-linked biglycan, in addition to a misalignment in the pre- and post-synaptic functional organizations. (imedpub.com)
  • The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages," The Journal of Clinical Investigation, vol. (thefreedictionary.com)
  • Importantly, when stimulated by LPS-induced proinflammatory factors, macrophages themselves are able to synthesize biglycan. (jci.org)
  • Our results provide evidence for what is, to our knowledge, a novel role of the matrix component biglycan as a signaling molecule and a crucial proinflammatory factor. (jci.org)
  • An approximately 125-kD dystroglycan-binding polypeptide was purified and shown by peptide microsequencing to be the Torpedo ortholog of the small leucine-rich repeat chondroitin sulfate proteoglycan biglycan. (nih.gov)
  • Glycosylation of alpha-dystroglycan is not necessary for this interaction, but binding is dependent upon the chondroitin sulfate side chains of biglycan. (nih.gov)
  • Biglycan is localized around the periphery of the muscle fiber and at all synapses. (nih.gov)
  • Biglycan bindsMuSKand the levels of this receptor tyrosine kinase are selectively reduced at bgn -/o synapses. (elsevier.com)
  • We have recently shown that biglycan signaling through TLR 2/4 and the CD14 co-receptor regulates inflammation, suggesting that TLR co-receptors may determine whether biglycan-TLR signaling is pro- or anti-inflammatory. (fraunhofer.de)
  • Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. (semanticscholar.org)
  • The specificity of the binding of biglycan and decorin to tropoelastin was confirmed by co-immunoprecipitation experiments and by the blocking of the interactions with elastin-derived peptides. (edu.au)
  • Co-immunoprecipitation experiments showed that MAGP-1 interacted with biglycan but not decorin in the solution phase. (edu.au)
  • Interfering with the interaction between biglycan and specific TLR co-receptors could represent a promising therapeutic intervention to curtail kidney inflammation and damage. (fraunhofer.de)
  • The collateral damage of the metalloproteinase/toxicity-removal process is the degraded fragments of ECM constituents such as hyaluronic acid, teanscin-c, decorin, biglycan , and aggrecan. (thefreedictionary.com)