Daphne
Cycas
Prenylation
Plant Extracts
Wikstroemia
Sesquiterpenes, Guaiane
Thymelaeaceae
Mycobacterium tuberculosis
Tea
Water
Calcium Sulfate
A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.
Taste
Glass
Humic Substances
Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).
Encyclopedias as Topic
Galaxies
Ice Cream
Stars, Celestial
Chromatography, High Pressure Liquid
Beverages
Cacao
Proanthocyanidins
Cycadophyta
Cupressaceae
Ferns
Seedless nonflowering plants of the class Filicinae. They reproduce by spores that appear as dots on the underside of feathery fronds. In earlier classifications the Pteridophyta included the club mosses, horsetails, ferns, and various fossil groups. In more recent classifications, pteridophytes and spermatophytes (seed-bearing plants) are classified in the Subkingdom Tracheobionta (also known as Tracheophyta).
Gymnosperms
Gymnosperms are a group of vascular plants whose seeds are not enclosed by a ripened ovary (fruit), in contrast to ANGIOSPERMS whose seeds are surrounded by an ovary wall. The seeds of many gymnosperms (literally, "naked seed") are borne in cones and are not visible. Taxonomists now recognize four distinct divisions of extant gymnospermous plants (CONIFEROPHYTA; CYCADOPHYTA; GINKGOPHYTA; and GNETOPHYTA).
Plant Leaves
Hepatophyta
Rosaceae
Papio ursinus
Antioxidants
Diospyros
Anthocyanins
Grape Seed Extract
Isomerism
Plant Proteins
Gene Expression Regulation, Plant
Chamaecyparis
Selaginellaceae
Hypericum
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
Ginkgo biloba
Cathepsin B
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. (1/171)
We have previously reported that proanthocyanidins extracted from grape seeds possess growth-promoting activity toward murine hair epithelial cells in vitro and stimulate anagen induction in hair cycle progression in vivo. This report constitutes a comparison of the growth-promoting activity of procyanidin oligomers and the target cells of procyanidins in the skin. Results show that procyanidin dimer and trimer exhibit higher growth-promoting activity than the monomer. The maximum growth-promoting activity for hair epithelial cells with procyanidin B-2, an epicatechin dimer, reached about 300% (30 microM) relative to controls (= 100%) in a 5 d culture. Optimum concentration of procyanidin C-1, an epicatechin trimer, was lower than that of procyanidin B-2; the maximum growth-promoting activity of procyanidin C-1 was about 220% (3 microM). No other flavonoid compounds examined exhibit higher proliferative activities than the procyanidins. In skin constituent cells, only epithelial cells such as hair keratinocytes or epidermal keratinocytes respond to procyanidin oligomers. Topical application of 1% procyanidin oligomers on shaven C3H mice in the telogen phase led to significant hair regeneration [procyanidin B-2, 69.6% +/- 21.8% (mean +/- SD); procyanidin B-3, 80.9% +/- 13.0%; procyanidin C-1, 78.3% +/- 7.6%] on the basis of the shaven area; application of vehicle only led to regeneration of 41.7% (SD = 16.3%). In this paper, we demonstrate the hair-growing activity of procyanidin oligomers both in vitro and in vivo, and their potential for use as agents to induce hair growth. (+info)Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. (2/171)
Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells. In this study, we examined the inhibitory effects of black tea polyphenols, including theaflavin (TF-1), a mixture (TF-2) of theaflavin-3-gallate (TF-2a) and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3) and the thearubigin fraction on the autophosphorylation of the EGF and PDGF receptors in A431 cells and mouse NIH3T3 fibroblast cells, respectively. First, we examined the effects of these polyphenols on the proliferation of A431 and NIH3T3 cells. Both EGCG and TF-3 strongly inhibited the proliferation of A431 and NIH3T3 cells more than the other theaflavins did. In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively. Other theaflavins slightly reduced the autophosphorylation of the EGF and PDGF receptors; furthermore, TF-3 could reduce autophosphorylation of the EGF receptor (or PDGF receptor) even with co-treatment with EGF (or PDGF) and TF-3, but EGCG was inactive under these conditions. In addition, TF-3 was stronger than EGCG in blocking EGF binding to its receptor. These results suggest that not only the green tea polyphenol, EGCG, but also the black tea polyphenol, TF-3, have an antiproliferative activity on tumor cells, and the molecular mechanisms of antiproliferation may block the growth factor binding to its receptor and thus suppress mitogenic signal transduction. (+info)Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. (3/171)
Procyanidins present in grape seeds are known to exert anti-inflammatory, anti-arthritic and anti-allergic activities, prevent skin aging, scavenge oxygen free radicals and inhibit UV radiation-induced peroxidation activity. Since most of these events are associated with the tumor promotion stage of carcinogenesis, these studies suggest that grape seed polyphenols and the procyanidins present therein could be anticarcinogenic and/or anti-tumor-promoting agents. Therefore, we assessed the anti-tumor-promoting effect of a polyphenolic fraction isolated from grape seeds (GSP) employing the 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted SENCAR mouse skin two-stage carcinogenesis protocol as a model system. Following tumor initiation with DMBA, topical application of GSP at doses of 0.5 and 1.5 mg/mouse/application to the dorsal initiated mouse skin resulted in a highly significant inhibition of TPA tumor promotion. The observed anti-tumor-promoting effects of GSP were dose dependent and were evident in terms of a reduction in tumor incidence (35 and 60% inhibition), tumor multiplicity (61 and 83% inhibition) and tumor volume (67 and 87% inhibition) at both 0.5 and 1.5 mg GSP, respectively. Based on these results, we directed our efforts to separate and identify the individual polyphenols present in GSP and assess their antioxidant activity in terms of inhibition of epidermal lipid peroxidation. Employing HPLC followed by comparison with authentic standards for retention times in HPLC profiles, physiochemical properties and spectral analysis, nine individual polyphenols were identified as catechin, epicatechin, procyanidins B1-B5 and C1 and procyanidin B5-3'-gallate. Five of these individual polyphenols with evident structural differences, namely catechin, procyanidin B2, procyanidin B5, procyanidin C1 and procyanidin B5-3'-gallate, were assessed for antioxidant activity. All of them significantly inhibited epidermal lipid peroxidation, albeit to different levels. A structure-activity relationship study showed that with an increase in the degree of polymerization in polyphenol structure, the inhibitory potential towards lipid peroxidation increased. In addition, the position of linkage between inter-flavan units also influences lipid peroxidation activity; procyanidin isomers with a 4-6 linkage showed stronger inhibitory activity than isomers with a 4-8 linkage. A sharp increase in the inhibition of epidermal lipid peroxidation was also evident when a gallate group was linked at the 3'-hydroxy position of a procyanidin dimer. Procyanidin B5-3'-gallate showed the most potent antioxidant activity with an IC(50) of 20 microM in an epidermal lipid peroxidation assay. Taken together, for the first time these results show that grape seed polyphenols possess high anti-tumor-promoting activity due to the strong antioxidant effect of procyanidins present therein. In summary, grape seed polyphenols in general, and procyanidin B5-3'-gallate in particular, should be studied in more detail to be developed as cancer chemopreventive and/or anticarcinogenic agents. (+info)Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. (4/171)
ras gene mutation, which perpetually turns on the growth signal transduction pathway, occurs frequently in many cancer types. The mouse epidermal JB6 cell line has been transfected with a mutant H-ras gene to mimic carcinogenesis in vitro. These transformed cells (30.7b Ras 12) are able to grow in soft agar, exhibiting anchorage independence and high endogenous activator protein 1 (AP-1) activity, which can be detected by a stable AP-1 luciferase reporter. The present study investigated the ability of different pure green and black tea polyphenols to inhibit this ras signaling pathway. The major green tea polyphenols (catechins), (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin, (-)-epicatechin-3-gallate, (-)-epicatechin, and their epimers, and black tea polyphenols, theaflavin, theaflavin-3-gallate, theaflavin-3'-gallate, and theaflavin-3,3'-digallate (TFdiG), were compared with respect to their ability to inhibit the growth of 30.7b Ras 12 cells and AP-1 activity. All of the tea polyphenols except (-)-epicatechin showed strong inhibition of cell growth and AP-1 activity. Among the catechins, both the galloyl structure on the B ring and the gallate moiety contributed to the growth inhibition and AP-1 activity; the galloyl structure appeared to have a stronger effect on the inhibitory action than the gallate moiety. The epimers of the catechins showed similar inhibitory effects on AP-1 activity. The addition of catalase to the incubation of the cells with EGCG or TFdiG did not prevent the inhibitory effect on AP-1 activity, suggesting that H2O2 does not play a significant role in the inhibition by tea polyphenols. Both EGCG and TFdiG inhibited the phosphorylation of p44/42 (extracellular signal-regulated kinase 1 and 2) and c-jun without affecting the levels of phosphorylated-c-jun-NH2-terminal kinase. TFdiG inhibited the phosphorylation of p38, but EGCG did not. EGCG lowered the level of c-jun, whereas TFdiG decreased the level of fra-1. These results suggest that tea polyphenols inhibited AP-1 activity and the mitogen-activated protein kinase pathway, which contributed to the growth inhibition; however, different mechanisms may be involved in the inhibition by catechins and theaflavins. (+info)Protection against peroxynitrite by cocoa polyphenol oligomers. (5/171)
Flavonoids, natural plant constituents, protect against peroxynitrite and can thereby play a role in defense against this mediator of inflammation. Procyanidin oligomers of different size (monomer through nonamer), isolated from the seeds of Theobroma cacao, were examined for their ability to protect against peroxynitrite-dependent oxidation of dihydrorhodamine 123 and nitration of tyrosine. By molarity, oligomers were more effective than the monomeric epicatechin; the tetramer was particularly efficient at protecting against oxidation and nitration reactions. These results suggest that epicatechin oligomers found in cocoa powder and chocolate may be a potent dietary source for defense against peroxynitrite. (+info)Procyanidin content and variation in some commonly consumed foods. (6/171)
Procyanidins are a subclass of flavonoids found in commonly consumed foods that have attracted increasing attention due to their potential health benefits. However, little is known regarding their dietary intake levels because detailed quantitative information on the procyanidin profiles present in many food products is lacking. Therefore, the procyanidin content of red wine, chocolate, cranberry juice and four varieties of apples has been determined. On average, chocolate and apples contained the largest procyanidin content per serving (164.7 and 147.1 mg, respectively) compared with red wine and cranberry juice (22.0 and 31.9 mg, respectively). However, the procyanidin content varied greatly between apple samples (12.3-252.4 mg/serving) with the highest amounts on average observed for the Red Delicious (207.7 mg/serving) and Granny Smith (183.3 mg/serving) varieties and the lowest amounts in the Golden Delicious (92.5 mg/serving) and McIntosh (105.0 mg/serving) varieties. The compositional data reported herein are important for the initial understanding of which foods contribute most to the dietary intake of procyanidins and may be used to compile a database necessary to infer epidemiological relationships to health and disease. (+info)Cocoa procyanidins and human cytokine transcription and secretion. (7/171)
We examined whether cocoa, in its isolated procyanidin fractions (monomer through decamer), would modulate cytokine production at the levels of transcription and protein secretion in both resting and phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC). In resting cells, interleukin (IL)-1beta and IL-4 gene expression from cocoa-treated cells varied markedly among the subjects tested. However, at the protein level, the larger fractions (pentamer through decamer) stimulated a dramatic increase in IL-1beta concentration (up to ninefold) with increasing degree of polymerization. Similarly, these larger fractions augmented IL-4 concentration by as much as 2 pg/ml, whereas the control displayed levels nearly undetectable. In the presence of PHA, gene expression also seemed to be most affected by the larger procyanidin fractions. The pentameric through decameric fractions increased IL-1 beta expression by 7-19% compared with PHA control, whereas the hexameric through decameric fractions significantly inhibited PHA-induced IL-4 transcription in the range of 71-86%. This observation at the transcription level for IL-1 beta was reflected at the protein level in PHA-stimulated PBMC. Significant reductions in mitogen-induced IL-4 production were also seen at the protein level with the hexamer, heptamer and octamer. Individual oligomeric cocoa fractions were unstimulatory for IL-2 in resting PBMC. However, when induced with PHA, the pentamer, hexamer and heptamer fractions caused a 61-73% inhibition in IL-2 gene expression. This study offers additional data for the consideration of the health benefits of dietary polyphenols from a wide variety of foods, including those benefits associated specifically with cocoa and chocolate consumption. (+info)Reactions of peroxynitrite with cocoa procyanidin oligomers. (8/171)
Peroxynitrite is a mediator molecule in inflammation, and its biological properties are being studied extensively. Flavonoids, which are natural plant constituents, protect against peroxynitrite and thereby could play an anti-inflammatory role. Procyanidin oligomers of different sizes (monomer through nonamer), isolated from the seeds of Theobroma cacao, were recently examined for their ability to protect against peroxynitrite-dependent oxidation of dihydrorhodamine 123 and nitration of tyrosine and were found to be effective in attenuating these reactions. The tetramer was particularly efficient at protecting against oxidation and nitration reactions. Epicatechin oligomers found in cocoa powder and chocolate may be a potent dietary source for defense against peroxynitrite. (+info)
Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.
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Analysis of black tea theaflavins by non-aqueous capillary electrophoresis. - Semantic Scholar
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A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology
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Polyphenols in Pycnogenol Improve Erectile Function and Lipid Profile
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Preparation of procyanidin B2 from apple pomace and its inhibitory effect on the expression of cyclooxygenase-2 in...
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Procyanidin B2 Improves Oocyte Maturation and Subsequent Development
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Procyanidin B2 inhibits high glucose‑induced epithelial‑mesenchymal transition in HK‑2 human renal proximal tubular epithelial...
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Pycnogenol (French Maritime Pine Bark Extract) Shown To Improve Visible Signs Of Aging In New Study - Redorbit
Absorption and Metabolism of Dietary Cocoa Procyanidins in Humans - Full Text View - ClinicalTrials.gov
Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract ...
Selaginella tamariscina PFAF Plant Database
Molecules | Free Full-Text | Inhibitory Activity of Synthesized Acetylated Procyanidin B1 Analogs against HeLa S3 Cells...
MANUFACTURING METHOD FOR THEAFLAVINS USING RAW TEA LEAVES - Patent application
IJMS | Free Full-Text | Structural Elucidation and Bioactivity of Biflavonoids from the Stems of Wikstroemia taiwanensis
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Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas...
Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa. | Cocoa Flavanol Science
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Human Health Benefits Evaluated in Research on Flavanols and Procyanidins
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Naturally occurring phenols
Biflavonoids Amentoflavone many (C6-C3)n,. (C6)n,. (C6-C3-C6)n n , 12 Lignins,. Catechol melanins,. Flavolans (Condensed ...
Cycas revoluta
Leaflets also contain biflavonoids. Estragole is the primary volatile compound emitted from the male and female cones of C. ... Moderately Active Antibacterial Biflavonoids. Abeer Moawad, Mona Hetta, Jordan K. Zjawiony, Melissa R. Jacob, Mohamed Hifnawy, ...
Lonicera japonica
The two biflavonoids, 3′-O-methyl loniflavone and loniflavone, along with luteolin and chrysin, can be isolated from the leaves ... Kumar, Neeraj; Singh, Bikram; Bhandari, Pamita; Gupta, Ajai P.; Uniyal, Sanjay K.; Kaul, Vijay K. (2005). "Biflavonoids from ...
Ochna lanceolata
Biflavonoids from Ochna lanceolata v t e. ...
Biflavonoid
Biflavonoids are a type of flavonoids with the general formula scheme (C6-C3-C6)2. Amentoflavone (bis-apigenin coupled at 8 and ... "Antimicrobial biflavonoids from the aerial parts of Ouratea sulcata". Phytochemistry. 66 (16): 1922-1926. doi:10.1016/j. ... revoluta contain biflavonoids such as (2S, 2′′S)-2,3,2′′,3′′-tetrahydro-4′,4′′′-di-O-methylamentoflavone ( ... Moderately active antibacterial biflavonoids". Planta Med. 76 (8): 796-802. doi:10.1055/s-0029-1240743. PMC 3711132. PMID ...
Amentoflavone
Williams, Christine A.; Harborne, Jeffrey B.; Tomas-Barberan A., Francisco (1987). "Biflavonoids in the primitive monocots ...
Ochnaflavone
To date, the field of biochemistry of biflavonoids is still wide open. Little is known about Ochnaflavone of its natural ...
Wikstroemia taiwanensis
"Structural Elucidation and Bioactivity of Biflavonoids from the Stems of Wikstroemia taiwanensis". International Journal of ...
Cycas circinalis
Leaflets of C. circinalis contain biflavonoids such as (2S, 2′′S)-2,3,2′′,3′′-tetrahydro-4′,4′′′-di-O-methylamentoflavone ( ... Phytochemical Investigation of Cycas circinalis and Cycas revoluta Leaflets: Moderately Active Antibacterial Biflavonoids. ...
Toxicodendron succedaneum
... a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavonoids". Planta Medica. 55 (2): 166-8. doi ...
Lophira alata
Both biflavonoids were obtained in small quantities, and their structures show some new and unusual biflavonoid diversity. ... The leaves of Lophira alata afforded two new biflavonoids, lophirone L (1) and lophirone M (2), and the known luteolin and ...
Morelloflavone
... , an isolate of Garcinia dulcis, belongs to the family of biflavonoids and is an inhibitor of HMG-CoA reductase. ...
پلیفنل - ویکیپدیا، دانشنامهٔ آزاد
1978). Direct synthesis, structure and absolute configuration of biflavonoids from black wattle bark (mimosa) extract. J. Chem ...
List of MeSH codes (D03)
... biflavonoids MeSH D03.438.150.266.450.206 - catechin MeSH D03.438.150.266.450.221 - chalcones MeSH D03.438.150.266.450.221.500 ... biflavonoids MeSH D03.830.219.266.450.206 - catechin MeSH D03.830.219.266.450.221 - chalcones MeSH D03.830.219.266.450.221.500 ...
Cycas beddomei
The biflavonoids 2",3"-dihydrohinokiflavone, 2,3,2",3"-tetrahydrohinokiflavone, 2,3-dihydroamentoflavone, 2,3,2",3"- ...
Molecules | Free Full-Text | Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno
The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied ... The flavanone-(3→8)-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly ... Six biflavonoids were isolated from G. madruno, one of which, 7-O-(6-acetyl)-glucoside of morelloflavone, is a new ... Six biflavonoids were isolated from G. madruno, one of which, 7-O-(6-acetyl)-glucoside of morelloflavone, is a new ...
IJMS | Free Full-Text | Structural Elucidation and Bioactivity of Biflavonoids from the Stems of Wikstroemia taiwanensis
Three new biflavonoids, wikstaiwanones A-C (1-3), along with four known compounds (4-7) were isolated from the stems of ... Three new biflavonoids, wikstaiwanones A-C (1-3), along with four known compounds (4-7) were isolated from the stems of ... Structural Elucidation and Bioactivity of Biflavonoids from the Stems of Wikstroemia taiwanensis. Li-Yin Chen 1,* , Ih-Sheng ... Chen L-Y, Chen I-S, Peng C-F. Structural Elucidation and Bioactivity of Biflavonoids from the Stems of Wikstroemia taiwanensis ...
Natural biflavonoids as potential therapeutic agents against microbial diseases - PubMed
Natural biflavonoids as potential therapeutic agents against microbial diseases José C J M D S Menezes 1 , Vinícius R Campos 2 ... Natural biflavonoids as potential therapeutic agents against microbial diseases José C J M D S Menezes et al. Sci Total Environ ... Antiviral activities of biflavonoids. Lin YM, Flavin MT, Schure R, Chen FC, Sidwell R, Barnard DL, Huffman JH, Kern ER. Lin YM ... Biochemical pharmacology of biflavonoids: implications for anti-inflammatory action. Kim HP, Park H, Son KH, Chang HW, Kang SS. ...
Profile for - iHerb.com
Naturally occurring phenols - Wikipedia
Ginkgoales
Quantitative analysis of flavan-3-ols in Spanish foodstuffs and beverages
Lignophytes, and Cycadales in particular
Pinales
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Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer | DR. NDAKALA...
Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer. ... and biflavonoids: chamaejasmin (3), 7,7″-di-O-methylchamaejasmin (4) and campylospermone A (5), a dimeric chromene [diphysin(6 ... "Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer." ...
In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella sellowii on Leishmania (Leishmania)...
S. sellowii may be a potential source of biflavonoids that could provide promising compounds for the treatment of cutaneous ... Animals , Female , Mice , Antiprotozoal Agents/therapeutic use , Biflavonoids/therapeutic use , Leishmania/drug effects , ... In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella sellowii on Leishmania (Leishmania) ... In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella ...
Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human...
The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. ... The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal ... Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4- ...
DNA topoisomerase inhibitors: biflavonoids from Ouratea species | Braz. j. med. biol. res;35(7): 819-822, July 2002. ilus |...
DNA topoisomerase inhibitors: biflavonoids from Ouratea species DNA topoisomerase inhibitors: biflavonoids from Ouratea species ... These biflavonoids and the acetyl derivative of II (IIa) are inhibitors of human DNA topoisomerases I at 200 æM, as ... These biflavonoids were assayed against human K562 leukemia cells in 45-h culture, but only I showed 42 percent growth ... The biflavonoids showed concentration-dependent growth inhibitory activities on Ehrlich carcinoma cells in 45-h culture, ...
The Flavonoids : Advances in Research since Nineteen Eighty by J. B. Harborne | 9780412287701 | Booktopia
Cycas revoluta - Wikipedia
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Pentameric procyanidins isolated from Theobroma cacao seeds selectively downregulate ErbB2 in human aortic endothelial cells.
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The Enzymology of Proanthocyanidin Biosynthesis | SpringerLink
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Presentation] Biflavonoids from the roots of Diplomorpha canescens. *. Author(s). Hari Prasad Devkota, Khem Raj Joshi, 渡邊高志, 矢原 ... Journal Article] Biflavonoids, Lignans and Related Compounds from the Roots of Diplomorpha canescens2015. *. Author(s). Hari ... Journal Article] Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoids from ...
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Frontiers | Metabolic Profile and Root Development of Hypericum perforatum L. In vitro Roots under Stress Conditions Due to...
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Flavonoids3
- Members of this family are characterised by the presence of flavonoids, biflavonoids and terpenoids as main secondary metabolites. (scielo.org.za)
- From Ormocarpum kirkii, a series of known flavonoids and biflavonoids was obtained, as well as three new compounds, i.e., 7,7′′-di-O-β-D-glucosyl-(−)-chamaejasmin, 7-O-β-D-glucosyl-(I-3,II-3)-biliquiritigenin, and isovitexin-(I-3,II-3)-naringenin. (sigmaaldrich.com)
- It contains flavonoids (flavonol glycoside and non-glycosidid biflavonoids), unique diterpene lactones (gingolides A, B, C, J and M) as well as a sesquiterpenoid (bilobalide). (ageless.co.za)
Amentoflavone3
- This study is the first phytochemical investigation of Selaginella sellowii and demonstrates the antileishmanial activity of the hydroethanolic extract from this plant (SSHE), as well as of the biflavonoids amentoflavone and robustaflavone, isolated from this species. (bvsalud.org)
- 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively. (bvsalud.org)
- Amentoflavone is one of the plant-derived biflavonoids currently being explored for potent pharmacological activities. (alliedacademies.org)
Polyflavonoids1
- This compound belongs to the class of organic compounds known as biflavonoids and polyflavonoids. (hmdb.ca)
Selaginella2
- Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts," Bioorganic and Medicinal Chemistry , vol. 16, no. 2, pp. 732-738, 2008. (hindawi.com)
- 2000. Cytotoxic biflavonoids from Selaginella deliccatula. (koreascience.or.kr)
Xanthones2
- Benzophenones are the major secondary metabolites in G. gummi-gutta, followed by xanthones and biflavonoids. (healthbenefitstimes.com)
- Previous activity-guided phytochemical studies on Garcinia buchananii stem bark, which is traditionally used in Africa to treat various gastrointestinal and metabolic illnesses, revealed xanthones, polyisoprenylated benzophenones, flavanone-C-glycosides, biflavonoids, and/or biflavanones as bioactive key molecules. (tum.de)
Cytotoxicity3
- Adem FA, Mbaveng AT, Kuete V, Heydenreich M, Ndakala A, Irungu B, Yenesew A, Efferth T. "Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer. (ac.ke)
- The aim of this study was to determine the cytotoxicity of isoflavones: osajin (1), 5,7-dihydroxy-4ˈ-methoxy-6,8-diprenylisoflavone (2) and biflavonoids: chamaejasmin (3), 7,7″-di-O-methylchamaejasmin (4) and campylospermone A (5), a dimeric chromene [diphysin(6)] and an ester of ferullic acid with long alkyl chain [erythrinasinate (7)] isolated from the stem bark and roots of the Kenyan medicinal plant, Ormocarpum kirkii. (ac.ke)
- 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. (duke.edu)
Cytotoxic1
- Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (duke.edu)
Sterols1
- Roots yielded biflavonoids and sterols. (stuartxchange.com)
Elucidation1
- Unequivocal structure elucidation of biflavonoids and biflavanones by means of NMR spectroscopy is often complicated by the hindered rotation of the monomers around the C-C axis (atropisomerism), resulting in a high spectral complexity. (tum.de)
Garcinia1
- Osorio E, Londoño J, Bastida J. Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno . (mdpi.com)
Therapeutic1
- Recent reports have shown that synthetic biflavonoids are now produced for specific therapeutic uses [ 6 ]. (alliedacademies.org)
Morelloflavone2
- Six biflavonoids were isolated from G. madruno , one of which, 7''- O -(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. (mdpi.com)
- The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE 50 of 12.36 μg/mL. (mdpi.com)
Constituents1
- Approximately 109 phytochemical constituents have been searched out as isolates from various parts of this plant comprising mostly diterpenoids and biflavonoids. (eurekaselect.com)
Medicinal1
- Biflavonoids are generally known for a wide number of pharmacological potentials in different countries and they are found in limited number of plants with interesting medicinal and pharmacological properties. (alliedacademies.org)
Procyanidin1
- Stafford, H.A. Enzymic regulation of procyanidin biosynthesis: lack of flav-3-en-3-ol intermediate. (springer.com)
Compounds3
- Three new biflavonoids, wikstaiwanones A-C ( 1 - 3 ), along with four known compounds ( 4 - 7 ) were isolated from the stems of Wikstroemia taiwanensis (Thymelaeaceae). (mdpi.com)
- S. sellowii may be a potential source of biflavonoids that could provide promising compounds for the treatment of cutaneous leishmaniasis . (bvsalud.org)
- Biflavonoids are unique biologically active naturally-occurring compounds for which the attentions of researchers have been drawn over the years. (alliedacademies.org)
Methyl1
- The two biflavonoids, 3′-O-methyl loniflavone and loniflavone, along with luteolin and chrysin, can be isolated from the leaves. (wikipedia.org)
Activity2
- The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu 2+ , was studied by means of a TBARS assay. (mdpi.com)
- These biflavonoids were assayed against human K562 leukemia cells in 45-h culture, but only I showed 42 percent growth inhibitory activity at 90 æM. (bvsalud.org)
Found3
- Biflavonoids found in oranges, grapefruit, lemons and limes. (msu.edu)
- Biflavonoids are found in citrus fruits. (nyhq.org)
- Flavone-flavone, flavanone-flavone and flavanone-flavanone are the common subunits found in plant-derived biflavonoids [ 1 , 4 ]. (alliedacademies.org)
Activities2
- The biflavonoids showed concentration-dependent growth inhibitory activities on Ehrlich carcinoma cells in 45-h culture, assayed by a tetrazolium method, with IC50 = 24 ± 1.4 æM for I, 26 ± 1.1 æM for II and 10 ± 0.7 æM for IIa. (bvsalud.org)
- Anti-virulence activities of biflavonoids from Mesua ferrea L. flower. (nih.gov)
Human1
- These biflavonoids and the acetyl derivative of II (IIa) are inhibitors of human DNA topoisomerases I at 200 æM, as demonstrated by the relaxation assay of supercoiled DNA, and only agathisflavone (I) at 200 æM also inhibited DNA topoisomerases II-alpha, as observed by decatenation and relaxation assays. (bvsalud.org)
Date1
- However, the connecting linkages are present at diverse positions yielding more than a hundred biflavonoids which have been isolated and structurally characterized till date [ 1 , 5 ]. (alliedacademies.org)
Benzophenones1
- Kennelly, E. J. - Benzophenones and Biflavonoids from Garcinia livingstonei Fruits, J. Agric. (ac.vn)
Agents1
- The result suggests that these biflavonoids maybe potential as insulin mimetics for developing antidiabetic agents. (ac.vn)