A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)
Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Drugs that selectively bind to and activate ADENOSINE A3 RECEPTORS.
Compounds that selectively bind to and block the activation of ADENOSINE A3 RECEPTORS.
Attachment of isoprenoids (TERPENES) to other compounds, especially PROTEINS and FLAVONOIDS.
An industrial solvent which causes nervous system degeneration. MBK is an acronym often used to refer to it.
Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)
A group of compounds with an 8-carbon ring. They may be saturated or unsaturated.
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The characteristic three-dimensional shape of a molecule.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.
Acidic water usually pH 2.5 to 4.5, which poisons the ecosystem and adversely affects plants, fishes, and mammals. It is caused by industrial pollutants, mainly sulfur oxides and nitrogen oxides, emitted into the atmosphere and returning to earth in the form of acidic rain water.
Proteins obtained from various species of Xenopus. Included here are proteins from the African clawed frog (XENOPUS LAEVIS). Many of these proteins have been the subject of scientific investigations in the area of MORPHOGENESIS and development.
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
The process of moving specific RNA molecules from one cellular compartment or region to another by various sorting and transport mechanisms.
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Substances that reduce the growth or reproduction of BACTERIA.
Dissertations embodying results of original research and especially substantiating a specific view, e.g., substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.
A metallic element, atomic number 49, atomic weight 114.82, symbol In. It is named from its blue line in the spectrum. (From Dorland, 28th ed)
Libraries in which a major proportion of the resources are available in machine-readable format, rather than on paper or MICROFORM.
Research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.
Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.

Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype. (1/1538)

Epibatidine, a neurotoxin isolated from the skin of Epipedobates tricolor, is an efficacious antinociceptive agent with a potency 200 times that of morphine. The toxicity of epibatidine, because of its nonspecificity for both peripheral and central nicotinic receptors, precludes its development as an analgesic. During the synthesis of epibatidine analogs we developed potent antinociceptive agents, typified by CMI-936 and CMI-1145, whose antinociception, unlike that of epibatidine, is mediated via muscarinic receptors. Subsequently, we used specific muscarinic toxins and antagonists to delineate the muscarinic receptor subtype involved in the antinociception evoked by these agents. Thus, the antinociception produced by CMI-936 and CMI-1145 is inhibited substantially by 1) intrathecal injection of the specific muscarinic M4 toxin, muscarinic toxin-3; 2) intrathecally administered pertussis toxin, which inhibits the G proteins coupled to M2 and M4 receptors; and 3) s.c. injection of the M2/M4 muscarinic antagonist himbacine. These results demonstrate that the antinociception elicited by these epibatidine analogs is mediated via muscarinic M4 receptors located in the spinal cord. Compounds that specifically target the M4 receptor therefore may be of substantial value as alternative analgesics to the opiates.  (+info)

Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties. (2/1538)

A novel macrolide, apicularen A, was produced by several species of the genus Chondromyces. Initially it was discovered by bioassay-guided RP-HPLC-fractionation of culture extracts of Chondromyces robustus, strain Cm a13. Apicularen A showed no antimicrobial activity, but was highly cytotoxic for cultivated human and animal cells, with IC50 values ranging between 0.1 and 3 ng/ml. A cometabolite of apicularen A, the N-acetylglucosamine glycoside apicularen B, was distinctly less cytotoxic with IC50 values between 0.2 and 1.2 microg/ml, and showed weak activity against a few Gram-positive bacteria. Apicularen A is chemically closely related to the salicylihalamides A and B from the marine sponge Haliclona sp.  (+info)

Identifying the bicyclomycin binding domain through biochemical analysis of antibiotic-resistant rho proteins. (3/1538)

Mutations M219K, S266A, and G337S in transcription termination factor Rho have been shown to confer resistance to the antibiotic bicyclomycin (BCM). All three His-tagged mutant Rho proteins exhibited similar Km values for ATP; however, the Vmax values at infinite ATP concentrations were one-fourth to one-third that for the His-tagged wild-type enzyme. BCM inhibition kinetics of poly(C)-dependent ATPase activity for the mutant proteins were non-competitive with respect to ATP (altering catalytic function but not ATP binding) and showed increased Ki values compared with His-tagged wild-type Rho. M219K and G337S exhibited increased ratios of poly(U)/poly(C)-stimulated ATPase activity and lower apparent Km values for ribo(C)10 in the poly(dC).ribo(C)10-dependent ATPase assay compared with His-tagged wild-type Rho. The S266A mutation did not show an increased poly(U)/poly(C) ATPase activity ratio and maintained approximately the same Km for ribo(C)10 in the poly(dC). ribo(C)10-dependent ATPase assay. The kinetic studies indicated that M219K and G337S altered the secondary RNA binding domain in Rho whereas the S266A mutation did not. Transcription termination assays for each mutant showed different patterns of Rho-terminated transcripts. Tyrosine substitution of Ser-266 led to BCM sensitivity intimating that an OH (hydroxyl) moiety at this position is needed for BCM (binding) inhibition. Our results suggest BCM binds to Rho at a site distinct from both the ATP and the primary RNA binding domains but close to the secondary RNA-binding (tracking) site and the ATP hydrolysis pocket.  (+info)

Latrunculin-A causes mydriasis and cycloplegia in the cynomolgus monkey. (4/1538)

PURPOSE: To determine the effect of latrunculin (LAT)-A, which binds to G-actin and disassembles actin filaments, on the pupil, accommodation, and isolated ciliary muscle (CM) contraction in monkeys. METHODS: Pupil diameter (vernier calipers) and refraction (coincidence refractometry) were measured every 15 minutes from 0.75 to 3.5 hours after topical LAT-A 42 microg (approximately 10 microM in the anterior chamber [AC]). Refraction was measured every 5 minutes from 0.5 to 1.5 hours after intracameral injection of 10 microl of 50 microM LAT-A (approximately 5 microM in AC), with intramuscular infusion of 1.5 mg/kg pilocarpine HCl (PILO) during the first 15 minutes of measurements. Pupil diameter was measured at 1 and 2 hours, and refraction was measured every 5 minutes from 1 to 2 hours, after intravitreal injection of 20 microl of 1.25 mM LAT-A (approximately 10 microM in vitreous), with intramuscular infusion of 1.5 mg/kg PILO during the first 15 minutes of measurements (all after topical 2.5% phenylephrine), and contractile response of isolated CM strips, obtained <1 hour postmortem and mounted in a perfusion apparatus, to 10 microM PILO +/- LAT-A was measured at various concentrations. RESULTS: Topical LAT-A of 42 microg dilated the pupil without affecting refraction. Intracameral LAT-A of 5 microM inhibited miotic and accommodative responses to intramuscular PILO. Intravitreal LAT-A of 10 microM had no effect on accommodative or miotic responses to intramuscular PILO. LAT-A dose-dependently relaxed the PILO-contracted CM by up to 50% at 3 microM in both the longitudinal and circular vectors. CONCLUSIONS: In monkeys, LAT-A causes mydriasis and cycloplegia, perhaps related to its known ability to disrupt the actin microfilament network and consequently to affect cell contractility and adhesion. Effects of LAT-A on the iris and CM may have significant physiological and clinical implications.  (+info)

Effect of 5-HT4 receptor stimulation on the pacemaker current I(f) in human isolated atrial myocytes. (5/1538)

OBJECTIVE: 5-HT4 receptors are present in human atrial cells and their stimulation has been implicated in the genesis of atrial arrhythmias including atrial fibrillation. An I(f)-like current has been recorded in human atrial myocytes, where it is modulated by beta-adrenergic stimulation. In the present study, we investigated the effect of serotonin (5-hydroxytryptamine, 5-HT) on I(f) electrophysiological properties, in order to get an insight into the possible contribution of I(f) to the arrhythmogenic action of 5-HT in human atria. METHODS: Human atrial myocytes were isolated by enzymatic digestion from samples of atrial appendage of patients undergoing coeffective cardiac surgery. Patch-clamped cells were superfused with a modified Tyrode's solution in order to amplify I(f) and reduce overlapping currents. RESULTS AND CONCLUSIONS: A time-dependent, cesium-sensitive increasing inward current, that we had previously described having the electrophysiological properties of the pacemaker current I(f), was elicited by negative steps (-60 to -130 mV) from a holding potential of -40 mV. Boltzmann fit of control activation curves gave a midpoint (V1/2) of -88.9 +/- 2.6 mV (n = 14). 5-HT (1 microM) consistently caused a positive shift of V1/2 of 11.0 +/- 2.0 mV (n = 8, p < 0.001) of the activation curve toward less negative potentials, thus increasing the amount of current activated by clamp steps near the physiological maximum diastolic potential of these cells. The effect was dose-dependent, the EC50 being 0.14 microM. Maximum current amplitude was not changed by 5-HT. 5-HT did not increase I(f) amplitude when the current was maximally activated by cAMP perfused into the cell. The selective 5-HT4 antagonists, DAU 6285 (10 microM) and GR 125487 (1 microM), completely prevented the effect of 5-HT on I(f). The shift of V1/2 caused by 1 microM 5-HT in the presence of DAU 6285 or GR 125487 was 0.3 +/- 1 mV (n = 6) and 1.0 +/- 0.6 mV (n = 5), respectively (p < 0.01 versus 5-HT alone). The effect of 5-HT4 receptor blockade was specific, since neither DAU 6285 nor GR 125487 prevented the effect of 1 microM isoprenaline on I(f). Thus, 5-HT4 stimulation increases I(f) in human atrial myocytes; this effect may contribute to the arrhythmogenic action of 5-HT in human atrium.  (+info)

The role of local actin instability in axon formation. (6/1538)

The role of localized instability of the actin network in specifying axonal fate was examined with the use of rat hippocampal neurons in culture. During normal neuronal development, actin dynamics and instability polarized to a single growth cone before axon formation. Consistently, global application of actin-depolymerizing drugs and of the Rho-signaling inactivator toxin B to nonpolarized cells produced neurons with multiple axons. Moreover, disruption of the actin network in one individual growth cone induced its neurite to become the axon. Thus, local instability of the actin network restricted to a single growth cone is a physiological signal specifying neuronal polarization.  (+info)

Amphidinolide B, a powerful activator of actomyosin ATPase enhances skeletal muscle contraction. (7/1538)

Amphidinolide B caused a concentration-dependent increase in the contractile force of skeletal muscle skinned fibers. The concentration-contractile response curve for external Ca2+ was shifted to the left in a parallel manner, suggesting an increase in Ca2+ sensitivity. Amphidinolide B stimulated the superprecipitation of natural actomyosin. The maximum response of natural actomyosin to Ca2+ in superprecipitation was enhanced by it. Amphidinolide B increased the ATPase activity of myofibrils and natural actomyosin. The ATPase activity of actomyosin reconstituted from actin and myosin was enhanced in a concentration-dependent manner in the presence or absence of troponin-tropomyosin complex. Ca2+-, K+-EDTA- or Mg2+-ATPase of myosin was not affected by amphidinolide B. These results suggest that amphidinolide B enhances an interaction of actin and myosin directly and increases Ca2+ sensitivity of the contractile apparatus mediated through troponin-tropomyosin system, resulting in an increase in the ATPase activity of actomyosin and thus enhances the contractile response of myofilament.  (+info)

Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation. (8/1538)

Ro 42-1611 (arteflene) is a synthetic endoperoxide antimalarial. The antimalarial activity of endoperoxides is attributed to iron(II)-mediated generation of carbon-centered radicals. An alpha, beta-unsaturated ketone (enone; 4-[2',4' bis(trifluoromethyl)phenyl]-3-buten-2-one), obtained from arteflene by reaction with iron(II), was identified previously as the stable product of a reaction that, by inference, also yields a cyclohexyl radical. The activation of arteflene in vivo has been characterized with particular reference to enone formation. [14C]Arteflene (35 micromol/kg) was given i.v. to anesthetized and cannulated male rats: 42.2 +/- 7.0% (mean +/- S.D., n = 7) of the radiolabel was recovered in bile over 5 h. In the majority of rats, the principal biliary metabolites were 8-hydroxyarteflene glucuronide (14.2 +/- 3. 9% dose, 0-3 h) and the cis and trans isomers of the enone (13.5 +/- 4.6% dose, 0-3 h). In conscious rats, 15.3 +/- 1.6% (mean +/- S.D., n = 8) of the radiolabel was recovered in urine over 24 h. The principal urinary metabolite appeared to be a glycine conjugate of a derivative of the enone. Biliary excretion of the glucuronide, but not of the enones, was inhibited by ketoconazole. 8-Hydroxyarteflene was formed extensively by rat and human liver microsomes but no enone was found. Bioactivation is a major pathway of arteflene's metabolism in the rat. Although the mechanism of in vivo bioactivation is unclear, the reaction is not catalyzed by microsomal cytochrome P-450 enzymes.  (+info)

(-)-Epibatidine dihydrochloride | Nicotinic agonist | Epibatidine | CAS [152378-30-8] | Axon 1078 | Axon Ligand™ with >99% purity available from supplier Axon Medchem, prime source of life science reagents for your research
Background Norcantharidin (NCTD) is a Chinese FDA approved, chemically synthesized drug for cancer treatment. The effect of NCTD on signaling proteins of EGFR and c-Met was systematically elucidated...
A facile synthetic method was developed for the novel acid-sensitive camptothecin norcantharidin acid ester derivatives 3in sealed tube. This method offers several advantages including high yield...
BioAssay record AID 629811 submitted by ChEMBL: Displacement of [3H]epibatidine from alpha4beta2 nAChR in Sprague-Dawley rat cerebral cortex by beta counting.
Norcantharidin (NCTD) is a Chinese FDA approved, chemically synthesized drug for cancer treatment. The effect of NCTD on signaling proteins of EGFR and c-Met was systematically elucidated in current study. Two human colon cancer cell lines, HCT116 and HT29, were used as model systems to investigate the anti-cancer molecular mechanism of NCTD. Cell cycle arrest and early/late apoptosis were analyzed by flow cytometry. The levels of EGFR, phospho-EGFR, c-Met, phospho-c-Met and other related proteins were quantified by western blot analysis. NCTD induced cell cycle arrest at G2/M phase in both cell lines. The early and late apoptosis was also observed. Further investigation indicated that NCTD suppressed not only the expression of the total EGFR and the phosphorylated EGFR but also the expression of the total c-Met and the phosphorylated c-Met in colon cancer cells. Moreover, EGFR expression could be mostly restored by co-treatment with MG132, a proteasome inhibitor. In addition, NCTD-induced cell death
TGF-β is a key profibrotic factor, but targeting TGF-β to prevent fibrosis also abolishes its protective anti-inflammatory effects. Here, we investigated the hypothesis that we can redirect TGF-β signaling by preventing downstream profibrotic interaction of β-catenin with T cell factor (TCF), thereby enhancing the interaction of β-catenin with Foxo, a transcription factor that controls differentiation of TGF-β induced regulatory T cells (iTregs), and thus, enhance anti-inflammatory effects of TGF-β In iTregs derived from EL4 T cells treated with recombinant human TGF-β1 (rhTGF-β1) in vitro, inhibition of β-catenin/TCF transcription with ICG-001 increased Foxp3 expression, interaction of β-catenin and Foxo1, binding of Foxo1 to the Foxp3 promoter, and Foxo transcriptional activity ...
Altabax (Retapamulin) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol/L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models following intermittent scheduling of doses below the maximally tolerated level..
China Buy 1, 8-Diazabicyclo[5.4.0]Undec-7-Ene CAS 6674-22-2, Find details about China 1 8-Diazabicyclo[5.4.0]Undec-7-Ene, 6674-22-2 from Buy 1, 8-Diazabicyclo[5.4.0]Undec-7-Ene CAS 6674-22-2 - Hefei TNJ Chemical Industry Co., Ltd.
Reductive amination of 2,5-diformylfuran (DFF) was used to implement the transition from bio-derived 5-hydroxymethylfurfural (HMF) to pharmaceuticals. The synthesized bis(aminomethyl)furans were utilized as building blocks for the construction of new derivatives with structural cores of naturally occurring biologically active compounds. Using the one-pot procedure, which included the Diels-Alder reaction followed by hydrogenation of the double bond, bio-derived analogues of the anticancer drug norcantharidin were obtained. The cyclization process was diastereoselective, and resulted in the formation of tricyclic products with the endo configuration. Analysis of cytotoxycity for the resulting tricyclic amine-containing compounds showed an increase of anticancer activity as compared with the unsubstituted norcantharimide.
Synthesis of conducting poly(3,4-ethylenedioxythiophene), PEDOT, is achieved through an original reduction-polymerization route: γ-radiolysis of aqueous solutions containing EDOT monomers under N2 atmosphere. According to UV-vis absorption spectrophotometry and ATR-FTIR spectroscopy, reduction of EDOT is initiated by hydrated electrons produced by water radiolysis and leads to PEDOT polymers through coupling reactions. The morphology of PEDOT is characterized by Cryo- TEM microscopy in aqueous solution and by SEM after deposition. In an original way, high resolution AFM microscopy, coupled with infrared nanospectroscopy, is used to probe the local chemical composition of PEDOT nanostructures. The results demonstrate that spherical self-assembled PEDOT nanostructures are formed. TGA analysis and four point probe measurements demonstrate that thermal stability and electrical conductivity of PEDOT polymers obtained by the present original reduction-polymerization method are close to those of PEDOT ...
One aspect of the present invention relates to diazabicyclo[4.3.0]nonanes. A second aspect of the present invention relates to the use of the diazabicyclo[4.3.0]nonanes as ligands for various cellular receptors, including opiate receptors. An additional aspect of the present invention relates to the use of the diazabicyclo[4.3.0]nonanes as analgesics.
To address the issue of binding selectivity among nAChR subtypes, we measured affinities of unlabeled 5-iodo-A-85380 in four different competition assays. To determine the affinity of 5-iodo-A-85380 for the α4β2 subtype, we used previously described competition assays with (±)-[3H]epibatidine or (-)-[3H]cytisine and P2 membrane fractions of Fischer-344 rat forebrain. Consistent with the previous observations (Koren et al., 1998), Scatchard plots of (±)-[3H]epibatidine binding to these rat brain membranes, at ligand concentrations of 1 to 800 pM, revealed a single population of binding sites (data not shown) with aK d of 9.5 ± 0.5 pM (n= 4). Similar high-affinity binding of (±)-[3H]epibatidine was observed in the rat (Houghtling et al., 1995), mouse (Marks et al., 1998), and human brain (Houghtling et al., 1995; Sihver et al., 1998), as well as in transfected cells stably expressing the α4β2 nAChR subtype (Houghtling et al., 1995; Whiteaker et al., 1998). In addition, the affinity of ...
Page contains details about platelet-derived growth factor-modified graphene oxide-doped poly(3,4-ethylenedioxythiophene) nanocomposite on gold . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Azasetron hydrochloride 123040-16-4 NMR spectrum, Azasetron hydrochloride H-NMR spectral analysis, Azasetron hydrochloride C-NMR spectral analysis ect.
DescriptionRecent investigations suggest that ligands such as steroids inhibit the binding of [35S] t-butylbicyclophosphorothionate ([35S] TBPS) to the convulsant site in the aminobutyric acid type A (GABAA) receptor complex. Currently, most interest is centered on ligands with [35S] TBPS displacement properties. Ligands binding to the GABAA receptor, block GABA-gated chloride ion flux in a non-competitive manner, resulting in convulsions. Traditionally, [35S] TBPS inhibition studies are measured using animal tests. Testing compounds, using rat tests, for potentially new ligands are costly and time-consuming. Therefore, developing computational models to predict potential [35S] TBPS displacement could provide many opportunities for the discovery and development of new ligands acting on the GABAA receptor convulsant site, resulting in the preventions of convulsions. In this study, Quantitative Structure Activity Relationship (QSAR) approaches were used to develop several computational models for ...
The IUPHAR/BPS Guide to Pharmacology. [3H]epibatidine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
The IUPHAR/BPS Guide to Pharmacology. [125I]epibatidine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
5-[5-[(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrazin-2-yl]-1H-indole | C18H19N5 | CID 46890772 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
(-)-Azasetron hydrochloride | 5-HT3 antagonist | CAS [123040-96-0] - [123040-95-9] | Axon 2535 | Axon Ligand™ with >100% purity available from supplier Axon Medchem, prime source of life science reagents for your research
Latrunculin immobilized cell was exposed to two opposing cyclic AMP gradients (see two micropipettes). The strength of the two gradients was alternated during the video ...
The thermoelectric properties of poly(3,4-ethylenedioxythiophene) (PEDOT)-based materials have attracted attention recently because of their remarkable electrical conductivity, power factor, and figure of merit. In this review, we summarize recent efforts toward improving the thermoelectric properties of PEDOT-based materials. We also discuss thermoelectric measurement techniques and several unsolved problems with the PEDOT system such as the effect of water absorption from the air and the anisotropic thermoelectric properties. In the last part, we describe our work on improving the power output of thermoelectric modules by using PEDOT, and we outline the potential applications of polymer thermoelectric generators.
Page contains details about ITO/PEDOT:PSS/BP/active layer/Ca/Al organic photovoltaic device . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is more than 60 days but less than or equal to 180 days. The sponsor cannot require changes to the communication and cannot extend the embargo ...
Abstract The synthesis of optically pure (1 S ,4 S )-2,5-diazabicyclo[2.2.1]heptane-1-carboxylic acid starting from easily available chiral pool l ...
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TY - JOUR. T1 - Latrunculin B and substratum stiffness regulate corneal fibroblast to myofibroblast transformation. AU - Thomasy, Sara M. AU - Raghunathan, Vijay Krishna. AU - Miyagi, Hidetaka. AU - Evashenk, Alexander T.. AU - Sermeno, Jasmyne C.. AU - Tripp, Geneva K.. AU - Morgan, Joshua T.. AU - Murphy, Christopher J. PY - 2018/5/1. Y1 - 2018/5/1. N2 - The transformation of keratocytes and fibroblasts to myofibroblasts is important to corneal wound healing as well as formation of stromal haze. The purpose of this study was to determine the effect of latrunculin B, an actin cytoskeleton disruptor in conjunction with a fundamental biophysical cue, substrate stiffness, on myofibroblast transformation in vitro and in vivo. Rabbit corneal fibroblasts were cultured on substrates of differing compliance (1.5, 22, and 71 kPa) and tissue culture plastic (TCP; , 1 GPa) in media containing 0 or 10 ng/ml TGFβ1 for 72 h. Cells were treated with 0.4 μM Lat-B or DMSO for 30 min every 24 h for 72 h. RNA ...
TY - JOUR. T1 - Organic solvent dispersion of poly(3,4-ethylenedioxythiophene) with the use of polymeric ionic liquid. AU - Kim, Tae Young. AU - Lee, Tae Hee. AU - Kim, Jonc Eun. AU - Kasi, Rajeswari M.. AU - Sung, Chong S.P.. AU - Suh, Kwang S.. PY - 2008/10/15. Y1 - 2008/10/15. N2 - A nonaqueous dispersion of poly(3,4-ethylenedioxythiophene) (PEDOT) was prepared with the use of polymeric ionic liquid (PIL) as a polymerization template and phase transfer medium. A detailed investigation was performed to understand the role of PIL in the course of polymerization and phase transfer reaction. On the basis of our findings from X-ray photoelectric spectroscopy (XPS), we propose a mechanism by which the PIL leads to the nanostructured PEDOT colloids in various organic solvents and thus facilitating smoother surface morphologies of the PEDOT-PIL films. In addition, the enhancement of charge transport was observed for PEDOT-PIL complex when compared with PEDOT without PIL. Raman spectroscopy indicates ...
Tedisamil (3,7-dicyclopropylmethyl-9,9-tetramethylene-3,7-diazabicyclo-3,3,1-nonane) is an experimental class III antiarrhythmic agent currently being investigated for the treatment of atrial fibrillation. Tedisamil blocks multiple types of potassium channels in the heart resulting in slowed heart rate. While the effects of tedisamil have been demonstrated in both atrial and ventricular muscle, repolarization is prolonged more efficiently in the atria. Tedisamil is administered intravenously and has a half-life of approximately 8 -13 hours in circulation. Tedisamil is being developed as an alternative to other antiarrhythmics as incidence of additional arrhythmic events is lower compared to other class III agents. Tedisamil also has significant anti-ischemic properties and was initially investigated as a potential treatment for angina until its antiarrhythmic effects were discovered. Tedisamil is manufactured by Solvay Pharmaceuticals Inc. under the proposed trade name Pulzium and is currently ...
TY - JOUR. T1 - Dinaciclib induces anaphase catastrophe in lung cancer cells via inhibition of cyclin-dependent kinases 1 and 2. AU - Danilov, Alexey V.. AU - Hu, Shanhu. AU - Orr, Bernardo. AU - Godek, Kristina. AU - Mustachio, Lisa Maria. AU - Sekula, David. AU - Liu, Xi. AU - Kawakami, Masanori. AU - Johnson, Faye M.. AU - Compton, Duane A.. AU - Freemantle, Sarah J.. AU - Dmitrovsky, Ethan. N1 - Funding Information: This study was supported by the National Cancer Institute grants R01- CA087546 (E. Dmitrovsky and S.J. Freemantle) and R01-CA190722 (E. Dmitrovsky and S.J. Freemantle), the SamuelWaxman Cancer Research Foundation Award (E. Dmitrovsky and D.A. Compton), by an American Cancer Society Clinical Research Professorship (E. Dmitrovsky), by a UT-STARS Award (E. Dmitrovsky), by a grant from Uniting Against Lung Cancer with Mary Jos Fund to Fight Cancer (S.J. Freemantle), and by an American Cancer Society Postdoctoral Fellowship (K.G Godek). Support to A.V. Danilov was provided by a ...
of the Gesellschaft Deutscher Chemiker 1994 International Edition in English 33/21 Pages 2121 -2228 COVER PICTURE The cover picture shows probably the most densely oxygenated complex fragment of ! The central triol-triacid core a natural product yet synthesized-C,,H,,O, (space-filling model at the top) of the fungal metabolite zaragozic acid A/squalestatin S1 (structural formula and space-filling model at the bottom) is depicted. Showing unprecedented promise as a medicinally useful inhibitor of squalene synthase (the enzyme controlling the first committed step in the biosynthesis of cholesterol), zaragozic acid A has attracted much attention in biological and chemical circles. The synthesis of the central core and the first total synthesis of zaragozic acid A/ squalestatin S1- -another race is over are described by K. C. Nicolaou et al. on p. 2184ff, 1187ff.. and 2190ff. (Red: oxygen. black: carbon, white: hydrogen; photograph: L. Gomez-Paloma, The Scripps Research Institute.) REVIEWS ...
Latrunculin and jasplakinolide modulate superoxide production in Ra2 microglia. Superoxide production in Ra2 cells pre-incubated with latrunculin or jasplakinol
Saniona is developing a fixed dose combination product, tesofensine/metoprolol, a biogenic monoamine uptake inhibitor and beta-1 adrenergic receptor antagonist,
Blockade of the checkpoint inhibitor programmed death 1 (PD1) has demonstrated remarkable success in the clinic for the treatment of cancer; however, a majority of tumors are resistant to anti-PD1 monotherapy. Numerous ongoing clinical combination therapy studies will likely reveal additional therapeutics that complement anti-PD1 blockade. Recent studies found that immunogenic cell death (ICD) improves T cell responses against different tumors, thus indicating that ICD may further augment antitumor immunity elicited by anti-PD1. Here, we observed antitumor activity following combinatorial therapy with anti-PD1 Ab and the cyclin-dependent kinase inhibitor dinaciclib in immunocompetent mouse tumor models. Dinaciclib induced a type I IFN gene signature within the tumor, leading us to hypothesize that dinaciclib potentiates the effects of anti-PD1 by eliciting ICD. Indeed, tumor cells treated with dinaciclib showed the hallmarks of ICD including surface calreticulin expression and release of high ...
1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) is a chemical compound with the formula C7H12N2.[1] It is an amidine base used in organic synthesis. A related compound with related functions is 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The relatively complex nature of the formal names for DBU and DBN (hence the common use of acronyms) reflects the fact that these compounds are bicyclic and contain several functional groups. ...
Two phase transitions consecutively reduce the crystal symmetry with rising temperature in 1,4-diazabicyclo[2.2.2]octane hydrobromide, [C6H13N2]+·Br−, dabcoHBr. Low-temperature prototypic hexagonal phase III, space group P [[6 with combining macron]] m2, Z = 1 above 458 K transforms into orientational states of...
The present invention is directed to methods of treating, preventing, and/or ameliorating systemic sclerosis, by administration of a therapeutically effective amount of ifetroban or a pharmaceutically acceptable salt thereof.
You are viewing an interactive 3D depiction of the molecule 2-[(8s,11s)-11-{(1r)-1-hydroxy-2-[(3-methylbutyl)(phenylsulfonyl)amino]ethyl}-6,9-dioxo-2-oxa-7,10-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-8-yl]acetamide (C29H40N4O7S) from the PQR.
CHEMVON BIOTECHNOLOGY: We are leading Manufacturer,Supplier & Exporter of Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester,
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Centanafadine (INN) (former developmental code name EB-1020) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that began its development with Euthymics Bioscience after they acquired DOV Pharmaceutical. It was developed as a treatment for attention-deficit hyperactivity disorder (ADHD) and inhibits the reuptake of norepinephrine, dopamine, and serotonin with a ratio of 1:6:14, respectively. In 2011, Euthymics Bioscience spun off its development of centanafadine to a new company called Neurovance. In March of 2017, Otsuka Pharmaceutical acquired Neurovance and the rights to centanafadine. As of January 2018, Otsukas pipeline indicates it is in Phase III clinical trials. Amitifadine Bicifadine Dasotraline DOV-216,303 Tesofensine Neurovances EB-1020 SR for Adult ADHD Shows Stimulant-Like Efficacy and Good Tolerability in Phase 2a Trial (PDF). Neurovance. Retrieved 14 January 2018. 3-Neurotransmitters, 1-Molecule: Optimized Ratios. Neurovance. EB-1020, a Non-Stimulant ...
This page contains information on the chemical 7-Oxabicyclo(4.1.0)hept-3-ene, 2,5-dibromo-, trans- including: 4 synonyms/identifiers.
Read Quantitative autoradiographic mapping of 5‐HT 3 receptors in the rat CNS using ( 125 I)iodo‐zacopride and ( 3 H)zacopride as radioligands, Synapse on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Jacek Gasiorowski, R. Menon, Kurt Hingerl, Marco Dachev, Serdar Niyazi Sariciftci, Surface morphology, optical properties and conductivity changes of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) by using additives , in Thin Solid Films, Nummer 536, Seite(n) 211, 2013, ISSN: 0040- ...
Structure, properties, spectra, suppliers and links for: 3-[(1S,4S)-Bicyclo[2.2.1]hept-5-en-2-yl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfon.
The objective of this phase 2a study is to evaluate the effect of tesofensine and metoprolol (Tesomet) in humans in relation to prevention of the increase in
a Schematic of cell structure. b Cross-sectional SEM image of PSCs with structure of ITO/PEDOT:PSS/GO/CH3NH3PbI3/PCBM/Ag. c J-V curves of PSCs with and without GO-modified PEDOT:PSS. The inset is dark J-V curves of PSCs. d UPS spectra of the PEDOT:PSS surface with and without GO ...
Pestunovich V.A.; Sidorkin V.F.; Shagun V.A.; Voronkov M.G.; Giller S.A.; Liepinsh E.E.; Eremeev A.V. Conformational analysis of 2-phenyl-1,3-diazabicyclo[3.1.0]hexane. Chem. Heterocycl. Compd. 1975, 11(7), 821-823 ...
View Notes - Week 3 Homework problem 10 and 11 from TERM 1 at FIT. From Equation 4.9 = * * + * + * PACt PCtA PAPCtA PA PCtB PB PCtC PC All of these are given = . * . . * . + . * . +( . * . )= . PACt
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 64285-06-9(Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-),please inquire us for 64285-06-9(Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-).
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Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. In between the ... A bicyclic compound can be carbocyclic (all of the ring atoms are carbons), or heterocyclic (the rings atoms consist of at ... Therefore, fused bicyclic compounds have a "0" included in the brackets. For example, decalin is named bicyclo[4.4.0]decane. ... For example, bicyclo[1.1.0]butane is typically called simply bicyclobutane. The heterocyclic molecule DABCO has a total of 8 ...
... bicyclo compounds MeSH D02.455.426.100.080.085 - bicyclo compounds, heterocyclic MeSH D02.455.426.100.080.100 - biperiden MeSH ... trialkyltin compounds MeSH D02.691.850.900.910 - triethyltin compounds MeSH D02.691.850.900.950 - trimethyltin compounds MeSH ... mustard compounds MeSH D02.455.526.728.468 - mustard gas MeSH D02.455.526.728.650 - nitrogen mustard compounds MeSH D02.455. ... trimethyl ammonium compounds MeSH D02.092.877.883.077 - betaine MeSH D02.092.877.883.088 - bethanechol compounds MeSH D02.092. ...
... is a tetracyclic compound and is grouped with the TeCAs. Its chemical name is N-methyl-9,10-ethanoanthracen-9(10H)- ... This results in it having a unique three-dimensional central ring (a bicyclo[2.2.2]octane or 1,4-endoethylenecyclohexane ring) ... In addition to its heterocyclic ring system, maprotiline has an alkylamine side chain attached similarly to other TCAs (but ... Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). "Pharmacological profile of antidepressants and related compounds at ...
... stereochemistry and anti-tetrabenazine activity of bicyclo analogues of 2-phenylmorpholines". Journal of Heterocyclic Chemistry ... Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects. Some also act as agonists at ... Some compounds have also become subject to illicit use as designer drugs. Substituted amphetamine Substituted benzofuran ... NIH PubChem Compound Summary for CID 3283983 Media related to Substituted phenylmorpholines at Wikimedia Commons. ...
DEAD can be used for synthesis of heterocyclic compounds. Thus, pyrazoline derivatives convert by condensation to α,β- ... Gassman PG, Mansfield KT (1969). "BICYCLO[2.1.0]PENTANE". Organic Syntheses. 49: 1. doi:10.15227/orgsyn.049.0001. ISSN 0078- ... Safety hazards have resulted in rapid decline of DEAD usage and replacement with DIAD and other similar compounds. Diethyl azo ... P. N. Preston (1980). Benzimidazoles and congeneric tricyclic compounds. John Wiley and Sons. pp. 475-. ISBN 978-0-471-08189-0 ...
This result suggested that there is a high selectivity for the 3° hydrogen, but the intermediate tertiary chloro compound 17 is ... Esposito, G.; Furstoss, R.; Waegell, B. (1971). "Synthese de la methyl-6, aza-6, bicyclo (3,2,1) octanone-4". Tetrahedron Lett ... Narayanan, V. L.; Setescak, L. (1971). "Synthesis of 1-methyladamantano[1,2-b]pyrrolidine, a novel heterocyclic system". J. Org ... Synthesis of 1,4-epimine compounds". J. Org. Chem. 48 (23): 4430-4432. doi:10.1021/jo00171a066. De Armas, P.; Carrau, R.; ...
Well-defined organometallic compounds have mainly been investigated for small-scale reactions or in academic research. The ... Michelotti, Francis W.; Keaveney, William P. (1965). "Coordinated Polymerization of the Bicyclo-(2.2.1)-heptene-2 Ring System ( ... Samojłowicz, C.; Grela, K. (2009). "Ruthenium-Based Olefin Metathesis Catalysts Bearing N-Heterocyclic Carbene Ligands". ... In any of the pairwise mechanisms with olefin pairing as rate-determining step this compound, a secondary reaction product of ...
During this period, he studied carbozincation reactions using allylic reagents and prepared bimetallic compounds bearing two ... Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane », ... Improved Air-Stable Solid Aromatic and Heterocyclic Zinc Reagents by Highly Selective Metalations for Negishi Cross-Couplings ... and Heteroarylmagnesium Compounds from Organic Bromides », Angew. Chem. Int. Ed., 2004, 43, p. 3333-3336 Krasovskiy, A.; ...
Application to the synthesis of heterocyclic compounds". Journal of Heterocyclic Chemistry. 33 (5): 1489-1496. doi:10.1002/jhet ... Heesing, A.; Herdering, W. (January 1981). "Sauerstoff-insertion bei der umlagerung von 2-aza-bicyclo[2.2.1]hept-2-enderivaten ... X/1, 4th Edition: Nitro, Nitroso and Hydroxylamine Compounds (4 ed.). Georg Thieme Verlag. p. 1266. ISBN 9783131805546. Ayres, ...
In a related system, N-heterocyclic carbene palladium complexes can be used in combination with various reductants in NMP or ... In this context, developing commercially viable, efficient and sustainable synthetic routes to these compounds requires both ... Access to Chiral Bicyclo[3.2.1]octanes". Angewandte Chemie International Edition. 58 (9): 2884-2888. doi:10.1002/anie.201900059 ... Hence, the development of new methods for applying reductive-Heck-like processes to these heterocyclic systems could have a ...
It was first synthesized by Curtius and Gloebel in 1888 and was the first compound containing a peptide bond to be studied by X ... conformationally constrained heterocyclic scaffolds in which diversity can be introduced at up to six positions and ... 5-diketopiperazine that possess a unique bicyclo[2.2.2]diazaoctane core ring system and is active against the human colon HCT- ... 2,5-Diketopiperazine, also known as piperazine-2,5-dione and as the cyclodipeptide cyclo(Gly-Gly), is an organic compound and ...
In 1970, he chaired the GRC conference on Hydrocarbon Chemistry, in 1971 the GRC on Heterocyclic Compounds; he was a member of ... 1,3]-Sigmatropic shifts for 5-X-bicyclo[2.1.0]pent-2-enes. An evaluation of the pseudopericyclic model". Journal of the ... This compound rearranges thermally to 1 with a half-life of ≥ 2 h at 360 °C, as compared with the parent hydrocarbon that ... Highly strained and highly reactive alkenes bicyclo[2.2.0]hex-1(4)-ene (13) and its perfluoro counterpart 14 provide another ...
Bicyclo(2.2.1)heptane-2-carbonitrile. *Biotin hydrazide. *2,3-Bis(acetylmercaptomethyl)quinoxaline ... This category is for stub articles relating to organic compounds. You can help by expanding them.. To add an article to this ... Pages in category "Organic compound stubs". The following 200 pages are in this category, out of approximately 1,151 total. ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Organic_compound_stubs&oldid=734103263" ...
Lam, Jørgen (1988). Chemistry and biology of naturally-occurring acetylenes and related compounds (NOARC): proceedings of a ... The Commission on the Nomenclature of Organic Chemistry (1971) [1958 (A: Hydrocarbons, and B: Fundamental Heterocyclic Systems ... Housane (bicyclo[2.1.0]pentane). *Norbornane (bicyclo[2.2.1]heptane). *Decalin (bicyclo[4.4.0]decane) ... These compounds are highly bioactive, e.g. as nematocides.[12] 1-Phenylhepta-1,3,5-triyne is illustrative of a naturally ...
"Photochemistry of conjugated cis-bicyclo[5.1.0]octenones, cis- and trans-bicyclo[5.2.0]non-2-en-4-ones, and their methylene ... Wilson, C. L.; Borchert, A. E. (1947). "Reactions of Furan Compounds. VII. Thermal Interconversionof 2,3-Dihydrofuran and ... Application to Synthesis of Biotin and the Heterocyclic Core of Plavix". J. Am. Chem. Soc. 129 (10): 2768-9. doi:10.1021/ ... Paquette, Leo A.; Henzel, Richard P.; Eizember, Richard F. (1973). "Thermochemical behavior of conjugated cis-bicyclo[5.1.0] ...
Half-cell potential of aromatic compounds against the SCE (Fc+/0)[24] Compound Potential (V) ... Xue, W.; Warshawsky, D. (2005). "Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A ... Housane (bicyclo[2.1.0]pentane). *Norbornane (bicyclo[2.2.1]heptane). *Decalin (bicyclo[4.4.0]decane) ... Compounds derived from biogenic precursors during early diagenesis". Geochimica et Cosmochimica Acta. 44 (3): 415-429. Bibcode: ...
The example shown is a facile reaction combining a 1-aza-bicyclo[2.2.1]heptane salt starting material with paraformaldehyde at ... This rearrangement can be used to form heterocyclic rings involving carbon, most commonly piperidine. One of the first examples ... although other silver and copper compounds have been used. This added step allows for more precise control of iminium ion ...
"IR- Coordination Compounds: Describing the Constitution of Coordination Compounds: Specifying donor atoms: General" (PDF ... Examples of polyhapto coordinated heterocyclic and inorganic rings: Cr(η5-C4H4S)(CO)3 contains the sulfur heterocycle thiophene ... Historically important compounds where the ligands are described with hapticity[edit]. *Ferrocene - bis(η5-cyclopentadienyl) ... W(CO)3(PPri3)2(η2-H2 ) - the first compound to be synthesized with a dihydrogen ligand.[8][9] ...
e) Any compound (not being a compound for the time being specified in paragraph 1(ba) of Part 1 of this Schedule) structurally ... by fusion of ring A with a heterocyclic system; (d) any substance which is an ester or ether (or, where more than one hydroxyl ... bicyclo[2.2.1]heptanyl, 1,2,3,4-tetrahydronaphthyl, quinolinyl, isoquinolinyl, 1-amino-1-oxopropan-2-yl, 1‑hydroxy-1-oxopropan- ... b) any compound (not being a compound for the time being specified in sub-paragraph (a) above) structurally derived from ...
Bridged Bicyclo Compounds, Heterocyclic / metabolism * DNA-Binding Proteins / genetics * DNA-Binding Proteins / metabolism* ...
Bridged Bicyclo Compounds, Heterocyclic / metabolism * Cell Cycle / physiology * Cytoskeleton / metabolism* * Dimethyl ...
PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ... Aza Compounds / pharmacology*. Bicyclo Compounds, Heterocyclic / pharmacology*. Breast Neoplasms / metabolism*. Cell Line, ... 0/2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one; 0/Antineoplastic Agents; 0/Aza Compounds; 0/Bicyclo Compounds, ... PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ...
0 (Actins); 0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Thiazolidines); 22144-77-0 (Cytochalasin D); EC 3.6.1.- (Myosin ...
0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (PCI 32765); 0 (Purines); 0 (Pyrazoles); 0 (Pyrimidines); 0 (Quinazolinones); 0 ...
Bicyclo Compounds [D04.075.080]. *Bicyclo Compounds, Heterocyclic [D04.075.080.875]. *Azabicyclo Compounds [D04.075.080.875.099 ... Heterocyclic Compounds, Bridged-Ring [D03.605]. *Bicyclo Compounds, Heterocyclic [D03.605.084]. *Penicillins [D03.605.084.737] ... Heterocyclic Compounds [D03]. *Heterocyclic Compounds, 2-Ring [D03.438]. *Bicyclo Compounds, Heterocyclic [D03.438.260] ...
Categories: Bicyclo Compounds, Heterocyclic Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
... research activities in the basic science involving heterocyclic synthesis,organometallic catalysis,photochemistry,etc.for ... S. M. Sondhi, R. Rani, A convenient, solvent free and high yielding synthesis of bicyclo-heterocyclic compounds, Letters in ... M. Nath, Toxicity and the cardio-vascular activity of organotin compounds: a review, Appl. Organomet. Chem., 2008, 22, 598-612. ... Singh, R. P. and Saxena P., Cobalt (II)-selective electrode based on a newly synthesized macrocyclic compound Sensors and ...
Bridged Bicyclo Compounds, Heterocyclic/pharmacology. *Carrier Proteins/genetics*. *Carrier Proteins/metabolism. *Cytoskeletal ...
... octane and bicyclo[3.3.1]nonane frameworks // Chemistry of Heterocyclic Compounds. New York : Springer. 2012, Vol. 48, no. 6, p ... The precursors are heterocyclic or aromatic compounds, each bearing a nitro group ortho to an internal alkyne. The developed ... editorial board member of the international journal Chemistry of Heterocyclic Compounds;. *member of the organising committee ... Study on cyclization reactions of heterocyclic compounds bearing ethynyl and formyl groups in close proximity to each other. ...
Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Cells, Cultured; Deoxyglucose; Electroporation; Endothelin-1; Enzyme ...
... about INDIUM COMPOUNDS. Search and download thousands of Swedish university dissertations. Full text. Free. ... The main focus of this thesis concerns the diastereoselective synthesis of heterocyclic compounds using main group elements as ... 3. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics. University dissertation ... Search for dissertations about: indium compounds. Showing result 1 - 5 of 9 swedish dissertations containing the words indium ...
Bicyclo Compounds. *Biphenyl Compounds. *Biphenyl Compounds: therapeutic use. *Carbolines. *Carbolines: therapeutic use ... Heterocyclic: therapeutic use. *Humans. *Indoles. *Indoles: therapeutic use. *Irritable Bowel Syndrome. *Irritable Bowel ...
Bicyclo Compounds [D04.075.080]. *Bicyclo Compounds, Heterocyclic [D04.075.080.875]. *Azabicyclo Compounds [D04.075.080.875.099 ...
Class Antineoplastics; Heterocyclic bicyclo compounds; Quinolines; Small molecules * Mechanism of Action Proto oncogene protein ... We do not sell or distribute the pharmaceutical compounds written about in this database. ...
Class Antihypertensives; Heterocyclic bicyclo compounds; Sulfonamides * Mechanism of Action ACE inhibitors; Diuretics ... We do not sell or distribute the pharmaceutical compounds written about in this database. ...
Heterocyclic compounds in which a 4-thia-1-aza-bicyclo[3.2.0] ring system is substituted at the 6-position with a carboxylic ... Heterocyclic compounds in which a 4-thia-1-azabicyclo[3.2.0]heptane ring system with a double bond is in between positions 2 ... Heterocyclic compounds in which a 4-thia-1-azabicyclo[3.2.0]heptane ring system with a double bond is in between positions 2 ... Heterocyclic compounds in which a 4-thia-1-azabicyclo[3.2.0]heptane ring system with a double bond is in between positions 2 ...
Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. In between the ... A bicyclic compound can be carbocyclic (all of the ring atoms are carbons), or heterocyclic (the rings atoms consist of at ... Therefore, fused bicyclic compounds have a "0" included in the brackets. For example, decalin is named bicyclo[4.4.0]decane. ... For example, bicyclo[1.1.0]butane is typically called simply bicyclobutane. The heterocyclic molecule DABCO has a total of 8 ...
... bicyclo compounds MeSH D02.455.426.100.080.085 - bicyclo compounds, heterocyclic MeSH D02.455.426.100.080.100 - biperiden MeSH ... trialkyltin compounds MeSH D02.691.850.900.910 - triethyltin compounds MeSH D02.691.850.900.950 - trimethyltin compounds MeSH ... mustard compounds MeSH D02.455.526.728.468 - mustard gas MeSH D02.455.526.728.650 - nitrogen mustard compounds MeSH D02.455. ... trimethyl ammonium compounds MeSH D02.092.877.883.077 - betaine MeSH D02.092.877.883.088 - bethanechol compounds MeSH D02.092. ...
The conformation of hetero cyclic spiro compounds part 3 the crystal and molecular structure of n beta hydroxyethyl granatanine ... Spiro hetero cyclic compounds 5. synthesis of spiro homo phthalimide 4 4' 4' h pyran compounds. Chemical and ... The bicyclo[3.3.1]nonane system adopts a boat-chair conformation. The structure is held together by a system of H- bonds. [ ... Journal of Heterocyclic Chemistry 17(1): 103-106, 1980. Synthesis of some new spiro hetero cyclic nitrogen compounds part 2. ...
Bicyclo Compounds, Heterocyclic. 1. + 237. Acid Sensing Ion Channels. 1. + 238. p38 Mitogen-Activated Protein Kinases. 1. + ...
Bicyclo Compounds, Heterocyclic Hormone Antagonists IN3 compound Indoles Oligopeptides Pyridines Receptors, LHRH Gonadotropin- ... Bicyclo Compounds, Heterocyclic Breast Neoplasms Cell Line Cell Membrane Female Gonadotrophs Gonadotropin-Releasing Hormone ...
Bicyclo Compounds, Heterocyclic. en_NZ. dc.subject. Cyanobacteria. en_NZ. dc.subject. Gas Chromatography-Mass Spectrometry. en_ ...
Bicyclo Compounds, Heterocyclic Biophysics Chronic Disease Disease Models, Animal Electric Stimulation Enzyme Inhibitors Gene ... Bicyclo Compounds, Heterocyclic Enzyme Inhibitors Lectins Multienzyme Complexes NAV1.7 Voltage-Gated Sodium Channel ...
Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Receptors, GABA-A; Muscimol; gamma- ... Bridged Bicyclo Compounds/metabolism; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Line/physiology; Chlorides/ ... Antibodies, Monoclonal, Convulsants, Bicuculline, Receptors, GABA-A, Chlorides, Bridged Bicyclo Compounds, DNA, gamma- ...
Bridged Bicyclo Compounds, Heterocyclic/chemistry*. *Crystallography, X-Ray. *Escherichia coli. *Homoserine/analogs & ...
Bridged Bicyclo Compounds, Heterocyclic/pharmacology. *Calcium/metabolism. *Gene Expression Regulation, Developmental/drug ...
Substances mentioned in the article: Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds ... Bridged Bicyclo Compounds/metabolism; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds/metabolism; Cerebral ... Bridged-Ring Compounds, tert-butylbicyclophosphorothionate, Ionophores, Bridged Bicyclo Compounds, Heterocyclic ... Receptors, GABA-A, Chlorides, Bridged Bicyclo Compounds, Sulfur Radioisotopes, Muscimol, ...
Bicyclo Compounds, Heterocyclic/pharmacology. *Cell Line, Tumor. *Cytoskeleton/drug effects/immunology. *Immunologic Capping/ ...
... but are less well studied with novel compounds. We assessed immunoglobulin heavy variable chain (IGHV) mutation status, common ... Bridged Bicyclo Compounds, Heterocyclic / administration & dosage Actions. * Search in PubMed * Search in MeSH ... but are less well studied with novel compounds. We assessed immunoglobulin heavy variable chain (IGHV) mutation status, common ...
  • The second and third parts concern the development of In(III)-catalyzed annulation of carbonyl compounds, amines, and alkynyl enones. (diva-portal.org)
  • The suitable carbonyl compounds contain a ketonic oxygen, for example one can use acetophenone or xanthone, and the amines can be primary, secondary or tertiary amines, for example, one can use butyldiethanolamine, triethanolamine, di-n-butylamine or morpholine. (google.ca)
  • 204159.23 6 Claims ABSTRACT OF THE DISCLOSURE Various combinations of certain organic carbonyl photosensitizer compounds and certain organic amine activators exert an unexpected beneficial etfect on the photopolymerization of certain polymerizable monomers or oligomers and coating compositions containing the same. (google.ca)
  • The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient. (justia.com)
  • Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions. (justia.com)
  • For example, a compound having the following structure: Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed. (justia.com)
  • The present invention relates to novel amidoheteroaryl aroyl hydrazide ethynes as tyrosine kinase inhibitors, process of preparation thereof, and use of the compounds for preparation of pharmaceutical compositions in the therapeutic treatment of disorders related to tyrosine kinases in humans. (justia.com)
  • The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium release-activated calcium (CRAC) channel modulators. (patentsencyclopedia.com)
  • Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient. (gc.ca)
  • Disclosed herein are pyrrolidinyl-based compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein. (sumobrain.com)
  • The invention provides chromoionophore compounds comprising a triazacryptand (TAC) K+ ionophore conjugated to at least a first chromophoric moiety (e.g., xanthylium dyes and derivatives thereof). (google.com)
  • In particular, coupling reactions of aryl-X compounds to give carboxylic acid derivatives, aldehydes, and ketones are described. (docme.ru)
  • Carbonylation of Aromatic (Pseudo)Halides to Carboxylic Acid Derivatives The palladium-catalyzed carbonylation of aryl X compounds to give carboxylic acid derivatives is becoming a valuable tool in organic synthesis. (docme.ru)
  • Derivatives of l-acetoxy-7,7-dimethyl-bicyclo[2.2.2]octan-5-one-2,3-dicarboximide. (ptfarm.pl)
  • WO 97/6168 forms prior art under Art 54(3) (4) EPC and discloses the use of bis-diazo compounds in the synthesis of diaza bicyclo compounds. (patent-de.com)
  • This chapter will mainly discuss heterocyclic compounds with relatively stable ring system and with a certain degree of aromaticity, also known as aromatic heterocyclic compound. (chemicalbook.com)
  • The first known use of the word "aromatic" as a chemical term-namely, to apply to compounds that contain the phenyl group-occurs in an article by August Wilhelm Hofmann in 1855. (prycewarner.com)
  • Synthesis, structural and association studies of chiral supramolecular polycyclic tectones based on bicyclo[3.3.1]nonane framework. (vu.lt)
  • The main focus of this thesis concerns the diastereoselective synthesis of heterocyclic compounds using main group elements as Lewis acid catalysts. (dissertations.se)
  • The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the. (patents.com)
  • Cover compounds containing one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system, with or without other non-condensed hetero rings. (uspto.gov)
  • Heterocyclic carbon compounds containing a hetero ring having chalcogen (i.e. (patentsencyclopedia.com)
  • Hetero ring is six-membered and includes at least nitrogen and oxygen as ring hetero atoms (e.g., monocyclic 1,2- and 1,3-oxazines, etc.) polycyclo ring system having the six-membered hetero ring as one of the cyclos (e.g., maytansinoids, etc.) bicyclo ring system having the six-membered hetero ring as one of the cyclos (e.g., 1,4-benzoxazines, etc. (patentsencyclopedia.com)
  • According to the number of hetero atoms, five-membered compounds and six-membered heterocyclic compounds can be divided into one-hetero-atom-containing heterocyclic compounds and two-hetero-atom-containing and several-hetero-atom-containing heterocyclic compounds. (chemicalbook.com)
  • purine, comprising more than two hetero atoms, is a several-hetero-atom-containing heterocyclic compound. (chemicalbook.com)
  • Three modes of ring junction are possible for a bicyclic compound: In spirocyclic compounds, the two rings share only one single atom, the spiro atom, which is usually a quaternary carbon. (wikipedia.org)
  • Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. (wikipedia.org)
  • The only exception to this requirement is that the compounds may contain metal atoms, but only as the cations of heterocyclic organic acid salts, alcoholates, phenolates or mercaptides, or as chelating atoms, e.g. in porphyrins. (uspto.gov)
  • Salts, chelates, alcoholates (except Ti/Zr), phenates involving a single ligand are classified as the parent compound (metal containing porphyrin C07D 487/22 ). (uspto.gov)
  • Azabicyclic heterocyclic Compound of general formula (I), or one of its salts with a base or an acid: in which R1, R2, R3, X, A and n are as herein described in the specification and claims. (allindianpatents.com)
  • A subject of the invention is also the salts of these compounds which can be obtained with bases or organic or inorganic acids, together with the internal salts in which form certain compounds may, under certain conditions, be present. (allindianpatents.com)
  • Examples of such energetic compounds include diazonium salts as well as compounds containing azo, azido, nitrato, and nitramino groups, such as nitrocellulose, polyvinyl nitrates, and the like. (patent-de.com)
  • A bicyclic compound can be carbocyclic (all of the ring atoms are carbons), or heterocyclic (the rings atoms consist of at least two elements), like DABCO. (wikipedia.org)
  • In fused bicyclic compounds, two rings share two adjacent atoms. (wikipedia.org)
  • In bridged bicyclic compounds, the two rings share three or more atoms, separating the two bridgehead atoms by a bridge containing at least one atom. (wikipedia.org)
  • For example, norbornane, also known as bicyclo[2.2.1]heptane, can be viewed as a pair of cyclopentane rings each sharing three of their five carbon atoms. (wikipedia.org)
  • The root of the compound name depends on the total number of atoms in all rings together, possibly followed by a suffix denoting the functional group with the highest priority. (wikipedia.org)
  • When naming simple fused bicyclic compounds, the same method as for bridged bicyclic compounds is applied, except the third path between the two bridgehead atoms now consists of zero atoms. (wikipedia.org)
  • The heterocyclic molecule DABCO has a total of 8 atoms in its bridged structure, hence the root name octane. (wikipedia.org)
  • The asymmetrical carbon atoms contained in the compounds of formula (I) can independently from one other have the R, S or RS configuration, and a subject of the invention is also therefore, the compounds of formula (I) presented in the form of pure enantiomers or pure diastereoisomers or in the form of a mixture of enantiomers in particular racemates, or diastereoisomer mixtures. (allindianpatents.com)
  • Heterocyclic compounds are a class of compounds that consist of carbon atoms and non-carbon atoms altogether forming a cyclic skeletal structure. (chemicalbook.com)
  • 公开了一种改进的多环大环化合物的合成方法,更具体地说,公开了一种改进的交联桥四氮杂大环 (google.com)
  • A ring-fused heterocyclic derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof having a T-type calcium channel regulatory effect and useful as a pruritus therapeutic and/or preventive agent, and the like are provided. (justia.com)
  • Int. Ed. 2000,- 39, n° 3, pages 625 to 62 8 the preparation of a compound with molecular formula C12H12N2O is in particular described. (allindianpatents.com)
  • R2, and R4 taken individually on one hand and X on the other hand can be in cis and/or trans position in .relation to the ring on which they are fixed and that a subject of the invention is therefore the compounds of formula (I) presented in the form of cis isomers or trans isomers or of mixtures. (allindianpatents.com)
  • A compound of formula (I). The present invention relates to therapeutically active .beta. (patents.com)
  • Heterocycles incorporating elements other than C, H, halogen, N, O, S, Se or Te are classified in subclass C07F , but only if the metal-containing compound has a metal carbon bond or if the metal is attached to at least two different ligands. (uspto.gov)
  • DOI: 10.1002/anie.200900013 Palladium Catalysis Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds Anne Brennfhrer, Helfried Neumann, and Matthias Beller* Keywords: aryl halides · carbon monoxide · carbonylation · homogeneous catalysis · palladium Dedicated to Professor Armin de Meijere on the occasion of his 70th birthday Angewandte Chemie 4114 www.angewandte.org 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew. (docme.ru)
  • Specifically, infrared light which has been generated by a laser is first absorbed by a radiation absorber (e.g., an infrared absorbing material such as an infrared dye, black alumina, or carbon black) and then converted to heat to decompose the energetic compound. (patent-de.com)
  • Many natural heterocyclic compounds in animals and plants play an important physiological role in the body. (chemicalbook.com)
  • In class C07 , the last place priority rule is used, i.e. in the absence of an indication to the contrary, a compound is classified in the last appropriate subclass. (uspto.gov)
  • Similarly, compounds containing saccharide radicals are classified in subclass C07H , and heterocyclic steroids are classified in subclass C07J . (uspto.gov)
  • This subclass is a structure-oriented entry for the compounds themselves and does not cover the application or use of the compounds under the subclass definition. (uspto.gov)
  • Heterocyclic compounds for producing dyes are classified in subclass C09B . (uspto.gov)
  • Preparations for medical, dental, or toilet purposes or methods of using compounds for the same purposes are classified in subclass A61K . (uspto.gov)
  • Biocidal, pest attractant, or plant growth regulatory activity of chemical compounds or preparations is further classified in subclass A01P (this subclass does only exist in IPC).Therapeutic activity of chemical compounds is further classified in subclass A61P . (uspto.gov)
  • Overall, the invention provides the chemistry for the compounds and for the processes to prepare compounds derived from 1,5-diazacyclooctanes. (patents.com)
  • According to the form of the ring in the molecule, heterocyclic compounds can be divided into single-heterocyclic compounds and fused heterocyclic compounds. (chemicalbook.com)
  • For example, bicyclo[1.1.0]butane is typically called simply bicyclobutane. (wikipedia.org)
  • Thus, a need exists for other compounds that will lower the threshold of ablation, increase sensitivity, and are useable with a wide variety of infrared dyes. (patent-de.com)
  • It is known that certain monomers and oligomers can be polymerized by exposure to different types of light energy and that such reactions may be accelerated by the presence in the reaction mixtures of known photosensitizers, including azo compounds, ketones, peroxides, organic sulfur compounds, organic dyes, metal carbonyls, etc. (google.ca)
  • No particular use of these compounds in the therapeutic field has been described in these documents. (allindianpatents.com)
  • The bicyclo[3.3.1]nonane system adopts a boat-chair conformation. (eurekamag.com)
  • A key intermediate in this catalytic system featuring a bicyclo[2,2,2]octane-like core has been successfully isolated and characterized, suggesting a new type of mechanism that involves the activation mode that mimics that of transition metal catalysts. (chem8.org)
  • Lithium Phenylethynolate and Its Reaction with Carbony1 Compounds to Give p-Lactones By Ulrich Schollkopf and lnga Hoppe'] While enolates ( I ) have numbered among the most important reagents of organic chemistry for more than a century, ynolates (2) have hitherto remained unknown although their chemistry should certainly be no less interesting than that of the former class of compounds. (docme.ru)
  • Study on cyclization reactions of heterocyclic compounds bearing ethynyl and formyl groups in close proximity to each other. (vu.lt)
  • Certain drugs or exogenous chemical compounds are known to affect inflammation. (lookformedical.com)
  • We do not sell or distribute the pharmaceutical compounds written about in this database. (springer.com)
  • 2. A pharmaceutical composition comprising the compound of claim 1, admixed with at least one pharmaceutically acceptable carrier, excipient or diluent. (gc.ca)
  • TREATMENT OF METABOLIC SYNDROME WITH NOVEL AMIDES - The present invention relates to the treatment of metabolic syndrome or disorders associated with metabolic syndrome comprising administering a compound of the invention. (patentsencyclopedia.com)
  • In accordance with the present invention, the sensitivity of laser induced thermal imaging systems can be increased by using diazo compounds that contain at least one electron withdrawing functional group adjacent the diazo substituent capable of stabilizing the diazo substituent (i.e., the =N + =N - substituent). (patent-de.com)
  • PurposeMicrotubule-stabilizing agents are an important class of anticancer compounds. (semanticscholar.org)
  • Lactones, lactams, cyclic ethers that we've already learned are heterocyclic compounds. (chemicalbook.com)
  • N-heterocyclic ylide-like germylene effectively promotes the hydroboration of aldehydes and ketones under mild conditions with broad substrate tolerance, operational simplicity of procedure and excellent yields. (chem8.org)
  • The invention relates to ionic compounds in which the anionic load has been delocalized. (google.com)
  • Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds. (docme.ru)
  • 1] This Review summarizes the recent work in the area of palladium-catalyzed carbonylation reactions of aryl halides and related compounds. (docme.ru)
  • The compounds can be used notably for ionic conducting materials, electronic conducting materials, colorant, and the catalysis of various chemical reactions. (google.com)
  • In 1878, the structure of piperidine was still unknown, and A. W. Hofmann made attempts to add hydrogen chloride or bromine to it in the belief that the compound possessed unsaturation (i.e. he performed standard alkene classification test reactions). (wikipedia.org)
  • Organic compounds containing at least one heterocyclic ring, and with no ring comprising a steroid, saccharide or peptide moiety. (uspto.gov)
  • In related embodiments, the chromoionophore compounds further comprise a second chromophoric moiety which. (google.com)
  • In related embodiments, the chromoionophore compounds further comprise a second chromophoric moiety which is insensitive to potassium binding by the TAC ionophore, thus providing for dual wavelength detection and absolute determination of K + concentration. (google.com)