Bicyclo Compounds, Heterocyclic
Octanes
Cyclization
Molecular Structure
Cycloaddition Reaction
Stereoisomerism
Adenosine A3 Receptor Antagonists
Prenylation
Methyl n-Butyl Ketone
Rhodium
Anti-Anxiety Agents
Receptor, Adenosine A3
Nucleosides
Hexanes
Magnetic Resonance Spectroscopy
Spectrophotometry, Infrared
Structure-Activity Relationship
Catalysis
Models, Molecular
Drug-protein binding and blood-brain barrier permeability. (1/549)
The permeability surface area (PS) product, an index of permeability of the blood-brain barrier (BBB), was measured by using the in situ perfusion method. In the cerebral circulation, the fraction of drug that permeates into the brain through the BBB is not only the unbound fraction but also the fraction dissociated from the protein in the perfusate. The sum of these two fractions, the apparent exchangeable fraction, was estimated by fitting the parameters of the BBB permeability under the condition of varying BSA concentrations in the perfusate. The unbound fraction of drugs in a buffer containing 0.5 mM BSA was measured by using the ultrafiltration method in vitro, and the apparent exchangeable fraction was measured in vivo by using the intracarotid artery injection method. The apparent exchange fraction was 100% for S-8510, 96.5% for diazepam, 90.9% for caffeine, 38.3% for S-312-d, 33.1% for propranolol, and 6.68% for (+)-S-145 Na, and each of these was higher than the corresponding unbound fraction in vitro in all drugs. The apparent exchangeable fractions, for example, were 8 times higher for diazepam and 38 times for S-312-d than the unbound fractions in vitro. The apparent exchangeable fraction of drugs was also estimated from the parameters obtained with the perfusion method. Because drugs can be infused for an arbitrary length of time in the perfusion method, substances with low permeability can be measured. The apparent exchangeable fractions obtained with this method were almost the same as those obtained with the intracarotid artery injection method. (+info)Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (2/549)
Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa. (+info)Isolation and structural determination of a novel bicyclic taxane diterpene from needles of the Chinese yew, Taxus mairei. (3/549)
A novel bicyclic taxane diterpene with a rare 12-membered ring was isolated from needles of the Chinese yew, Taxus mairei, and its structure was established as (3E, 8E)-2 alpha, 7 beta, 9, 10 beta, 13 alpha, 20-hexaacetoxy-5(2'-acetoxy-cinnamoyloxy)-3,8-secotaxa -3,8,11-triene (1) with the help of 1D and 2D NMR data. The relative stereochemistry was deduced from a NOESY experiment. (+info)Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury. (4/549)
We examined the effects of modulating group II metabotropic glutamate receptors (mGluRs) on traumatic neuronal injury using both in vitro and in vivo models. Treatment with various selective group II mGluR agonists significantly decreased lactate dehydrogenase release, a marker of cell death, after traumatic injury to rat neuronal-glial cultures; injury-induced increases in cyclic AMP and glutamate levels were also significantly reduced by a group II agonist. The neuroprotective effects of group II agonists were markedly attenuated by coadministration of a group II antagonist or a membrane-permeable cyclic AMP analog and were additive to those provided by an N-methyl-D-aspartate receptor antagonist or a selective group I mGluR antagonist. Administration of a group II mGluR agonist 30 min after lateral fluid percussion-induced brain injury in rats significantly improved subsequent behavioral recovery as compared with vehicle-treated controls. Together these studies indicate that group II mGluR agonists protect against traumatic neuronal injury by attenuating glutamate release and cAMP levels and suggest a potential role for these agents in the treatment of clinical neurotrauma. (+info)Endothelium-derived contracting factor in carotid artery of hypertensive Dahl rats. (5/549)
The present study is designed to investigate whether acetylcholine (ACh) elicits an endothelium-derived contracting factor (EDCF) and whether it contributes to decreased relaxant response induced by ACh in Dahl rats. Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a 0.4% NaCl or an 8% NaCl diet for 4 weeks. High sodium intake significantly increased blood pressure in DS rats but not in DR rats. The carotid rings were suspended for isometric tension recording. ACh caused an endothelium-dependent contraction in carotid rings from hypertensive DS rats but not from normotensive Dahl rats. Atropine, indomethacin, SQ29548, or ONO-3708 (prostaglandin H(2) [PGH(2)]/thromboxane A(2) [TXA(2)] receptor antagonist) abolished ACh-induced contraction, and OKY-046 (inhibitor of TXA(2) synthetase) partially attenuated the contraction. High sodium intake significantly enhanced contraction evoked by U46619, a PGH(2)/TXA(2) receptor agonist, in both DS and DR rats. In contrast, ACh-induced relaxation was significantly depressed in the rings from hypertensive DS rats, and ONO-3708 partially improved the depressed relaxation. Administration of ONO-8809 (an orally active PGH(2)/TXA(2) receptor antagonist; 30 micrograms per body per day) for 4 weeks neither reduced blood pressure nor improved the depressed ACh-induced relaxation in hypertensive DS rats. These results suggest that ACh causes release of EDCF in carotid rings of hypertensive DS rats, which is likely to be PGH(2) and TXA(2). The EDCF contributed in part to the depressed ACh-induced relaxation. (+info)Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes. (6/549)
Type II pneumocytes, which synthesize, store, and secrete pulmonary surfactant, require exogenous fatty acids, in particular palmitic acid, for maximum surfactant synthesis. The uptake of palmitate by type II pneumocytes is thought to be protein mediated, but the protein involved has not been characterized. Here we show by RT-PCR and Northern blot analysis that rat type II pneumocytes express the mRNA for fatty acid translocase (FAT/CD36), a membrane-associated protein that is known to facilitate the uptake of fatty acids into adipocytes. The deduced amino acid sequence from rat type II pneumocytes reveals 98% identity to the FAT/CD36 sequence obtained from rat adipocytes. The uptake of palmitate by type II pneumocytes follows Michaelis-Menten kinetics (Michaelis-Menten constant = 11.9 +/- 1.8 nM; maximum velocity = 62.7 +/- 5.8 pmol. min(-1). 5 x 10(5) pneumocytes(-1)) and decreases reversibly under conditions of ATP depletion to 35% of control uptake. Incubation of cells at 0 degrees C inhibited the uptake of palmitate almost completely, whereas depletion of potassium was without effect. Preincubation of the cells with bromobimane or phloretin decreases the uptake of palmitate significantly as does preincubation with sulfo-N-succinimidyl oleate, the specific inhibitor of FAT/CD36 (C. M. Harmon, P. Luce, A. H. Beth, and N. A. Abumrad. J. Membr. Biol. 121: 261-268, 1991). From these data, we conclude that FAT/CD36 is expressed in type II pneumocytes and mediates the uptake of palmitate in a saturable and energy-dependent manner. The data suggest that the uptake process is independent of the formation of coated pits and endocytotic vesicles. (+info)Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1. (7/549)
Extracts of Hypericum perforatum (St. John's Wort) are widely used for the treatment of depressive disorders and are unspecific inhibitors of the neuronal uptake of several neurotransmitters. Previous studies have shown that hyperforin represents the reuptake inhibiting constituent. To characterize the mechanism of serotonin reuptake inhibition, kinetic analyses in synaptosomes of mouse brain were performed. Michaelis-Menten kinetics revealed that hyperforin (2 microM) induces a decrease in V(max) by more than 50% while only slightly decreasing K(m), indicating mainly noncompetitive inhibition. By contrast, citalopram (1 nM) leads to an elevation of K(m) without changing V(max). Monensin, a Na(+)/H(+) exchanger, showed similar properties as hyperforin (decrease of V(max) without changing K(m)). Compared with classical antidepressants, such as selective serotonin reuptake inhibitors and tricyclic antidepressants, hyperforin is only a weak inhibitor of [(3)H]paroxetine binding relative to its effects on serotonin uptake. As monensin decreases serotonin uptake by increasing Na(+)/H(+) exchange, we compared the effects of hyperforin and monensin on the free intracellular sodium concentration ([Na(+)](i)) in platelets by measuring 1,3-benzenedicarboxylic acid, 4,4'-[1,4,10-trioxa-7, 13-diazacyclopentadecan-7,13-diylbis(5-methoxy-6, 2-benzofurandiyl)]bis-, tetraammonium salt (SBFI/AM) fluorescence. Both drugs elevated [Na(+)](i) over basal levels, with a maximal [Na(+)](i) of 69 +/- 16.1 mM (50 microM hyperforin) and 140 +/- 9.1 mM (10 microM monensin). Citalopram at concentrations relevant for [(3)H]serotonin uptake inhibition had no effect on [Na(+)](i). Although the mode of action of hyperforin seems to be associated with elevated [Na(+)](i) similar to those levels found with monensin, the molecular mechanism might be different, as even at high concentrations, hyperforin does not elevate free intracellular sodium concentration ([Na(+)](i)) up to the extracellular level, as monensin does. Hyperforin represents the first substance with a known preclinical antidepressant profile that inhibits serotonin uptake by elevating [Na(+)](i). (+info)Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist. (8/549)
A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL. (+info)
Polyquinane
The simplest polyquinane is the bicyclic compound bicyclo[3.3.0]octane. Other members are triquinacene and dodecahedrane. The ... A polyquinane polycyclic compound consisting of fused five-membered hydrocarbon rings. If the compound is unsaturated instead ... compound triquinacene, sometimes simply called quinacene (tricyclo[5.2.1.04,10]deca-2,5,8-triene) is the second member of a ... it was found to have no such properties-and also as part of a failed attempt to synthesize the then-elusive compound ...
Bicyclic molecule
Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. In between the ... Therefore, fused bicyclic compounds have a "0" included in the brackets. For example, decalin is named bicyclo[4.4.0]decane. ... When naming simple fused bicyclic compounds, the same method as for bridged bicyclic compounds is applied, except the third ... An example of a spirocyclic compound is the photochromic switch spiropyran. In fused/condensed bicyclic compounds, two rings ...
Brevianamide
Structurally similar to paraherquamides, they are a small class compounds that contain a bicyclo[2.2.2]diazoctane ring system. ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with ...
Bicyclo(1.1.1)pentane
Bicyclo[1.1.1]pentane is an organic compound, the simplest member of the bicyclic bridged compounds family. It is a hydrocarbon ... Bicyclo[1.1.1]pentane is a highly strained molecule. Kenneth Wiberg and Frederick Walker used bicyclo[1.1.1]pentane to make [ ... The bicyclo[1.1.1]pentane structure has been used as an unusual bioisostere for a phenyl ring. Housane Wiberg, Kenneth B.; ... "Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally ...
Bicyclo(6.2.0)decapentaene
Bicyclo[6.2.0]decapentaene is a bicyclic organic compound and an isomer of naphthalene and azulene. Whether this substance is ... Bicyclo[6.2.0]decapentaene can be synthesised in a multistep process from bicyclo[4.2.0]octa-3,7-diene-2,5- dione. This is ... Bicyclo[6.2.0]decapentaene dissolves in pentane. Bicyclo[6.2.0]decapentaene reacts with oxygen in air. When heated to 100 °C it ... Unlike aromatic compounds, it has alternating bond lengths in the rings. One double bond is in the exclusive part of the four ...
Norbornane
... (also known as bicyclo[2.2.1]heptane) is an organic compound and a saturated hydrocarbon with chemical formula C7H12 ... and is a bridged bicyclic compound. The compound is a prototype of a class of strained bicyclic hydrocarbons. The compound was ... It is a crystalline compound with a melting point of 88 °C. The carbon skeleton is derived from cyclohexane ring with a ... das Bicyclo-[1.2.2]-heptan, und die stereoisomeren Norborneole". Naturwissenschaften. 22: 171. doi:10.1007/BF01496254. ...
Barrelene
... is a bicyclic organic compound with chemical formula C8H8 and systematic name bicyclo[2.2.2]octa-2,5,7-triene. First ... Synthesis of Substituted Bicyclo[2.2.2]octatrienes Michael W. Wagaman, Erika Bellmann, Michèle Cucullu, and Robert H. Grubbs J ... Iptycenes, with the alkene groups part of an arenes, are related compounds. It is also a starting material for many other ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without EBI source ...
Bredt's rule
... but the similar compound bicyclo[2.2.1]heptan-7-one-1-carboxylic acid remains stable beyond 500 °C, despite both being β-keto ... There has been an active research program to seek compounds inconsistent with the rule, and for bicyclic systems a limit of S ... For example, bicyclo[5.3.1]undecane-11-one-1-carboxylic acid undergoes decarboxylation on heating to 132 °C, ... Köbrich, Gert (1973). "Bredt Compounds and the Bredt Rule". Angew. Chem. Int. Ed. 12 (6): 464-473. doi:10.1002/anie.197304641. ...
Homoaromaticity
Instead, the group proposed the structure of the bicyclo[5.1.0]octadienyl compound, theorizing that the cyclopropane bond ... Similarly, a substituted bicyclo[3.2.1]octa-3,6-dien-2-yl cation (the 2-(4'-Fluorophenyl) bicyclo[3.2.1]oct-3,6-dien-2-yl ... These anionic compounds are often prepared from their neutral parent compounds through lithium metal reduction. 1,2- ... Just as aromatic compounds exhibit exceptional stability, antiaromatic compounds, which deviate from Huckel's rule and contain ...
Decalin
... (decahydronaphthalene, also known as bicyclo[4.4.0]decane and sometimes decaline), a bicyclic organic compound, is an ... ". "MSDS Sheet - JT Baker". (Chemical articles with multiple compound IDs, Chemicals using indexlabels, Chemical articles with ...
Iptycene
An iptycene is an aromatic compound composed of varying number of arene subunits bound to a bridged bicyclo-octatriene core ... v t e (Polycyclic aromatic hydrocarbons, All stub articles, Aromatic compound stubs). ...
List of chemical compounds with unusual names
Doering, W. von E.; Roth, W. R. (1963). "A Rapidly Reversible Degenerate Cope Rearrangement : Bicyclo[5.1.0]octa-2,5-diene". ... Verbrugge, P. A. (1977). "Unusual organic compounds. XXIV. Compounds with the formula (CH)n. (d). Synthesis of cubane, (CH)8; ... Monk, Felonious (13 April 2006). "Chemical Cock-ups: A Story of How Not to Name a Chemical Compound". h2g2: The guide to life, ... Chemical nomenclature, replete as it is with compounds with complex names, is a repository for some names that may be ...
List of organic reactions
Stigler's law of eponymy Name reaction List of organic compounds List of inorganic compounds Named inorganic compounds List of ... X.1,2 The Reaction of Benzenesulfonyl Azide with Norbornadiene, Dicyclopentadiene, and Bicyclo[2.2.2]-2-octene". The Journal of ... Bowers, A.; Halsall, T. G.; Jones, E. R. H.; Lemin, A. J. (1953). "The chemistry of the triterpenes and related compounds. Part ... Bowden, K.; Heilbron, I. M.; Jones, E. R. H.; Weedon, B. C. L. (1946). "Researches on acetylenic compounds. Part I. The ...
List of MeSH codes (D02)
... bicyclo compounds MeSH D02.455.426.100.080.085 - bicyclo compounds, heterocyclic MeSH D02.455.426.100.080.100 - biperiden MeSH ... trialkyltin compounds MeSH D02.691.850.900.910 - triethyltin compounds MeSH D02.691.850.900.950 - trimethyltin compounds MeSH ... mustard compounds MeSH D02.455.526.728.468 - mustard gas MeSH D02.455.526.728.650 - nitrogen mustard compounds MeSH D02.455. ... trimethyl ammonium compounds MeSH D02.092.877.883.077 - betaine MeSH D02.092.877.883.088 - bethanechol compounds MeSH D02.092. ...
Vanda tessellata
A compound decoction of this root is administered in cases of Hemiplegia as some Indian physicians consider it useful in ... 7-tri methyl bicyclo [2.2.1] heptane) has been found in the orchid in 2013. The plant produces an alkaloid, a glucoside, ... A Subramoniam, A Gangaprasad, P K Sureshkumar, J Radhika and B K Arun (18 April 2013). A novel aphrodisiac compound from an ... and exhibit potent analgesic effects combined with a relatively low toxicity A novel aphrodisiac compound ( 2,7, ...
Tandospirone
3-bicyclo(2.2.1)heptanedicarboximide(Tandospirone) and Related Compounds". Chemical and Pharmaceutical Bulletin. 39 (9): 2288- ... Journal of Labelled Compounds and Radiopharmaceuticals. 31 (6): 427-436. doi:10.1002/jlcr.2580310602. ISSN 0362-4803. John ...
Transition state
One demonstration of this principle is found in the two bicyclic compounds depicted below. The one on the left is a bicyclo[2.2 ... Rickert Reaction in the Structures of Bicyclo[2.2.2]octadiene and Bicyclo[2.2.2]octene Derivatives". The Journal of Organic ... Compared to the compound on the right (which, lacking an alkene group, is unable to give this reaction) the bridgehead carbon- ... For these two compounds the prediction holds up based on X-ray crystallography. One way that enzymatic catalysis proceeds is by ...
Bicyclo(2.2.1)heptane-2-carbonitrile
v t e (Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles ... Bicyclo[2.2.1]heptane-2-carbonitrile is a chemical which is classified as an extremely hazardous substance in the United States ...
Exo-Norborneol
Reaction of organic compounds under high temperature - dilute acid (HTDA) conditions. III. The perdeuteration of bicyclo[2.2.1] ... v t e (Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles ... Commercially available, this colorless compound may be prepared by the reaction of norbornene with formic acid, followed by ...
Norcarane
... , or bicyclo[4.1.0]heptane, is a colorless liquid. It is an organic compound prepared using the Simmons-Smith reaction ...
Bicyclopentane
... pentane Bicyclo[2.1.0]pentane (housane) Bicyclopentyl [Wikidata] (cyclopentylcyclopentane) Bicyclic compound Bicyclobutane ... Spiropentane This set index page lists chemical compounds articles associated with the same name. If an internal link led you ...
Ladderane
Both routes leverage a small [2]-ladderene building block bicyclo[2.2.0]hexene prepared by a Ramberg-Bäcklund reaction. The ... Trans-ladderanes have not been synthesized due to the ring strain in these compounds. The second stereochemical relationship ... Various synthetic methods have been used for the laboratory synthesis of ladderane compounds. The three major approaches are (1 ... Elimination of H-Br and addition of an organozinc compound installs the alkyl alcohol. A hydrazine-mediated deoxygenation ...
Twistane
... (IUPAC name: tricyclo[4.4.0.03,8]decane) is an organic compound with the formula C10H16. It is a cycloalkane and an ... The original 1962 method was based on a bicyclo[2.2.2]octane framework. A 1967 publication concerned an intramolecular aldol ... Theory Comput., 2015,11(3), 1020-1026 doi:10.1021/ct5011505 (Chemical articles with multiple compound IDs, Chemicals using ... The compound was first reported by Whitlock in 1962. Twistane has been synthesized in a variety of ways. ...
1.1.1-Propellane
The compound 1,3-dehydroadamantane, which can be viewed as a bridged [1.3.3]propellane, also polymerizes in a similar way. [2.2 ... Propellane Bicyclo(1.1.1)pentane which lacks a bond between the bridgehead carbons. "Houben-Weyl Methods of Organic Chemistry ... 1.1.1]Propellane is an organic compound, the simplest member of the propellane family. It is a hydrocarbon with formula C5H6 or ... 3-di-carboxylic acid of bicyclo[1.1.1]pentane 1 in a Hunsdiecker reaction to the corresponding dibromide 2 followed by a ...
Maprotiline
... is a tetracyclic compound and is grouped with the TeCAs. Its chemical name is N-methyl-9,10-ethanoanthracen-9(10H)- ... This results in it having a unique three-dimensional central ring (a bicyclo[2.2.2]octane or 1,4-endoethylenecyclohexane ring) ... Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). "Pharmacological profile of antidepressants and related compounds at ... and being a tetracyclic rather than a tricyclic compound. However, it could also or alternatively be considered to be a ...
Endo-Norborneol
The perdeuteration of bicyclo[2.2.1]heptanes PDF J. K. Stille, and Fred M. Sonnenberg (1966). "The Reaction of endo- and exo-2- ... v t e (Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles ... Exo-Norborneol (+)-endo-2-Norborneol at Sigma-Aldrich endo-Norborneol MSDS Reaction of organic compounds under high temperature ...
EPA list of extremely hazardous substances
Benzotrichloride Benzyl chloride Benzyl cyanide Bicyclo(2.2.1)heptane-2-carbonitrile Bis(chloromethyl) ketone Bitoscanate Boron ... trichloride Boron trifluoride Boron trifluoride compound with dimethyl ether (1:1) Bromadiolone Bromine Cadmium oxide Cadmium ...
Substituted phenylmorpholine
Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects. Some also act as agonists at ... stereochemistry and anti-tetrabenazine activity of bicyclo analogues of 2-phenylmorpholines". Journal of Heterocyclic Chemistry ... Some compounds have also become subject to illicit use as designer drugs. Substituted amphetamine Substituted benzofuran ... NIH PubChem Compound Summary for CID 3283983 Media related to Substituted phenylmorpholines at Wikimedia Commons (Articles with ...
Dewar benzene
The compound itself was first synthesized in 1962 as a tert-butyl derivative and then as the unsubstituted compound by Eugene ... Bicyclo[2.2.0]hexa-2,5-dienes (Dewar benzenes)". J. Am. Chem. Soc. 93 (23): 6092-6101. doi:10.1021/ja00752a021. Hoffmann, Roald ... The compound is named after James Dewar who included this structure in a list of possible C6H6 structures in 1869. However, he ... The compound has nevertheless considerable strain energy and reverts to benzene with a chemical half-life of two days. This ...
Organocobalt chemistry
Organocobalt compounds are known with alkene, allyl, diene, and Cp ligands. A famous sandwich compound is cobaltocene, a 19- ... B. K. Bower and H. G. Tennent (1972). "Transition metal bicyclo[2.2.1]hept-1-yls". J. Am. Chem. Soc. 94 (7): 2512-2514. doi: ... Organocobalt compounds are involved in several organic reactions and the important biomolecule vitamin B12 has a cobalt-carbon ... Other sandwich compounds are CoCp(C6Me6) and Co(C6Me6)2, with 20 electrons and 21 electrons, respectively. Reduction of ...
2,5-Diketopiperazine
... is an organic compound with the formula (NHCH2C(O))2. The compound features a six-membered ring containing ... 5-diketopiperazine that possess a unique bicyclo[2.2.2]diazaoctane core ring system and is active against the human colon HCT- ... It was first compound containing a peptide bond to be characterized by X-ray crystallography in 1938. It is the parent of a ... In food systems, 2,5-diketopiperazines have been shown to be important sensory compounds contributing to the taste of the final ...
Intramolecular reaction
... and aza-bicyclo[2,1,1]hexanes". J. Chem. Soc. D. 19 (19): 1167. doi:10.1039/C29710001167. Corey, E. J.; Kang, M. C.; Desai, M. ... many intramolecular reactions that would not occur as an intermolecular reaction between two compounds take place. Examples of ... reactions have been used to synthesize organic compounds with interesting ring systems and topologies. For example, [2+2] ...
Patchoulol
Contains embedded bicyclo[2.2.2]octane motif. Norpatchoulenol Deguerry, F.; Pastore, L.; Wu, S.; Clark, A.; Chappell, J.; ... The (−)-optical isomer is one of the organic compounds responsible for the typical patchouli scent. Patchoulol is also used in ...
Baldwin's rules
Gold-Catalyzed Synthesis of Bicyclo[4.3.0]nonadiene Derivatives via Tandem 6-endo-dig/Nazarov Cyclization of 1,6-Allenynes J. ... Nazarov cyclization tandem catalysed by a gold compound: A 5-endo-dig ring closing reaction was part of a synthesis of (+)- ... chemistry are a series of guidelines outlining the relative favorabilities of ring closure reactions in alicyclic compounds. ...
Bioorthogonal chemistry
Symmetrical cyclooctynes such as BCN (bicyclo[6.1.0]nonyne) form a single regioisomer upon cycloaddition and may serve to ... and it has also been used in the generation of SPECT imaging compounds. More recently, the use of an oxanorbornadiene was ... The reaction must be selective between endogenous functional groups to avoid side reactions with biological compounds ... imaging agents which must be made quickly with high purity and yield in order to minimize isotopic decay before the compounds ...
Aza-Cope rearrangement
The example shown is a facile reaction combining a 1-aza-bicyclo[2.2.1]heptane salt starting material with paraformaldehyde at ... although other silver and copper compounds have been used. This added step allows for more precise control of iminium ion ...
Vinylcyclopropane (5+2) cycloaddition
Yu and co-workers reported a unique variant of the reaction that preferentially forms bridged bicyclic compounds. Martin and co ... Cycloaddition of cis-Allene-vinylcyclopropanes to Synthesize the Bicyclo[4.3.1]decane Skeleton". Angewandte Chemie. 56 (30): ...
Iodomethylzinc iodide
... bicyclo[4.1.0]heptane). Iodomethylzinc iodide may also be generated by the reaction of diazomethane with zinc iodide, or by the ... 5, p. 855 (Iodo complexes, Organozinc compounds). ...
Stieglitz rearrangement
Heesing, A.; Herdering, W. (January 1981). "Sauerstoff-insertion bei der umlagerung von 2-aza-bicyclo[2.2.1]hept-2-enderivaten ... X/1, 4th Edition: Nitro, Nitroso and Hydroxylamine Compounds (4 ed.). Georg Thieme Verlag. p. 1266. ISBN 9783131805546. Ayres, ... Application to the synthesis of heterocyclic compounds". Journal of Heterocyclic Chemistry. 33 (5): 1489-1496. doi:10.1002/jhet ...
Tropoxane
List of cocaine analogues O-2172 Meltzer PC, Blundell P, Chen Z, Yong YF, Madras BK (March 1999). "Bicyclo[3.2.1]octanes: ... Heterocyclic compounds with 2 rings). ...
Simmons-Smith reaction
Unfortunately, as in Pathway B shown the intermediate can also react with the starting diazo compound, giving cis- or trans- 1, ... Thus, cyclohexene, diiodomethane, and a zinc-copper couple (as iodomethylzinc iodide, ICH2ZnI) yield norcarane (bicyclo[4.1.0] ... However, both reactions require near stoichiometric amounts of the starting metal compound, and Sm/Hg must be activated with ... The Charette Modification replaces the CH2I2 normally found in the Simmons-Smith reaction with aryldiazo compounds, such as ...
Danheiser annulation
... bicyclo-[4.3.0]non-8-en-2-one". Organic Syntheses. 66: 8. doi:10.15227/orgsyn.066.0008. Alfred Hassner; C. Stumer (2002). ... New Annulation Approaches to Five and Six-Membered Carbocyclic Compounds". Tetrahedron Letters. 26 (21): 2513. doi:10.1016/ ...
Field effect (chemistry)
This can be attributed to a field effect because in the same compound with the chlorines pointed away from the acidic group the ... Cole, Thomas W.; Mayers, Carolyn J.; Stock, Leon M. (1974). "Chemistry of the bicyclo[2.2.2]octanes. XV. Dissociation constants ... These effects can therefore help to tune the acidity/basicity of a molecule to protonate/deprotonate a specific compound, or ... For example, the three compounds to the right, all octanes, differ only in the number of linkers between the electron ...
Cobalt(II) chloride
... is an inorganic compound of cobalt and chlorine, with the formula CoCl 2. The compound forms several ... Barton K. Bower & Howard G. Tennent (1972). "Transition metal bicyclo[2.2.1]hept-1-yls". J. Am. Chem. Soc. 94 (7): 2512-2514. ... compounds, work that led to an understanding of the structures of such coordination compounds. Reaction of 1-norbornyllithium ... "Cobalt and Cobalt Compounds" (CS1 maint: uses authors parameter, Chemical articles with multiple compound IDs, Multiple ...
Vinylcyclopropane rearrangement
"Photochemistry of conjugated cis-bicyclo[5.1.0]octenones, cis- and trans-bicyclo[5.2.0]non-2-en-4-ones, and their methylene ... Wilson, C. L.; Borchert, A. E. (1947). "Reactions of Furan Compounds. VII. Thermal Interconversionof 2,3-Dihydrofuran and ... Paquette, Leo A.; Henzel, Richard P.; Eizember, Richard F. (1973). "Thermochemical behavior of conjugated cis-bicyclo[5.1.0] ... octenones, cis- and trans-bicyclo[5.2.0]non-2-en-4-ones, and their methylene analogs". The Journal of Organic Chemistry. 38 (19 ...
Mizoroki-Heck vs. Reductive Heck
In this context, developing commercially viable, efficient and sustainable synthetic routes to these compounds requires both ... Access to Chiral Bicyclo[3.2.1]octanes". Angewandte Chemie International Edition. 58 (9): 2884-2888. doi:10.1002/anie.201900059 ... deuterium-labeled compounds are accessible by using D2O in the reaction, allowing easy access to deuterated chiral oxindoles. ... δ-alkenyl carbonyl compounds were suitable substrates for the reaction; however, internal alkenes proved to be more challenging ...
Serotonin-norepinephrine-dopamine reuptake inhibitor
On removal of the 2C tropane bridge and on going from RTI-31 to the simpler SS and RS Nocaine it was seen that these compounds ... n-dimethylaminomethyl-bicyclo-2,2,2-octane, hydrochloride". Life Sciences. 23 (10): 1041-7. doi:10.1016/0024-3205(78)90664-1. ... This is based on the fact that the compound is bicyclic and therefore does not adhere to the equation given above. It is ... Hence, this might be viewed as a strategy for increasing the safety of the compounds and would also be preferable to use in ...
Spin states (d electrons)
Bower, Barton K.; Tennent, Howard G. (1972). "Transition Metal Bicyclo[2.2.1]hept-1-yls". Journal of the American Chemical ... ISBN 0-13-841891-8. Gütlich, P. (2001). "Photoswitchable Coordination Compounds". Coordination Chemistry Reviews. 219-221: 839- ...
Hydroxylamine-O-sulfonic acid
Also sulfur compounds (such as thioethers) can be aminated with hydroxylamine-O-sulfonic acid to sulfinimines (isosteric with ... Rathke, Michael W.; Millard, Alan A. (1978). "Boranes in functionalization of olefins to amines: 3-Pinanamine (Bicyclo[3.1.1] ... Hydroxylamine-O-sulfonic acid (HOSA) is the inorganic compound with molecular formula H3NO4S that is formed by the sulfonation ... Wiberg, Egon; Wiberg, Nils (2001). "Sulfur Compounds of Nitrogen". Inorganic Chemistry. Academic Press. pp. 675-677. ISBN 978-0 ...
Organic azide
Chemistry of Heterocyclic Compounds: A Series Of Monographs. New York, USA: John Wiley & Sons, Inc. doi:10.1002/0471221902. ... "Reactions of Bicyclo[2.2.1]hept-5-ene-2,3-dicarboximides with Aromatic Azides". Russian Journal of Organic Chemistry. 40 (7): ... The azo-transfer compounds, trifluoromethanesulfonyl azide and imidazole-1-sulfonyl azide react with amines to give the ... On a new class of compounds in which nitrogen is substituted for hydrogen". Proceedings of the Royal Society of London. 13: 375 ...
List of phenyltropanes
N.B. In the case of both nocaine and pethidine, N-demethyl compounds are more toxic and have a decreased seizure threshold. ... "Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors", published 2004- ... Therefore it is to be expected that within different contexts a compound or chemical of the same name very possibly could be in ... Compound 48 Irreversible (phenylisothiocyanate) binding ligand (Murthy, V.; Martin, T. J.; Kim, S.; Davies, H. M. L.; Childers ...
Quadricyclane
... is produced by the irradiation of norbornadiene (bicyclo[2.2.1]hepta-2,5-diene) in the presence of Michler's ... Tetracyclic compounds). ...
David M. Lemal
This compound rearranges thermally to 1 with a half-life of ≥ 2 h at 360 °C, as compared with the parent hydrocarbon that ... 1,3]-Sigmatropic shifts for 5-X-bicyclo[2.1.0]pent-2-enes. An evaluation of the pseudopericyclic model". Journal of the ... In 1970, he chaired the GRC conference on Hydrocarbon Chemistry, in 1971 the GRC on Heterocyclic Compounds; he was a member of ... Highly strained and highly reactive alkenes bicyclo[2.2.0]hex-1(4)-ene (13) and its perfluoro counterpart 14 provide another ...
MESH TREE NUMBER CHANGES - 2008 MeSH
Advanced Search Results - Public Health Image Library(PHIL)
DeCS
Bridged Bicyclo Compounds - Preferred Concept UI. M000611179. Scope note. Saturated alicyclic hydrocarbon molecules consisting ... Bridged Bicyclo Compounds Entry term(s). Bicyclo Compounds, Bridged Bicyclo Compounds - Related but not broader or narrower ... Bicyclo Compounds. Bicyclo Compounds, Bridged. Tree number(s):. D02.455.426.100.080. D04.075.080. ...
Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster<...
Genitalia. Medical search
MESH TREE NUMBER CHANGES - 2008 MeSH
Thomas H. Kinstle
A long- term program in the chemistry of strained bicyclic ring compounds is proceeding in the areas of synthesis, mechanism ... We are particularly interested in partially fluorinated bicyclo[2.1.0] pentanes. Flash vacuum pyrolysis techniques have allowed ... organic chemistry is concerned with the synthesis and biological evaluation analogs of plant derived phenolic compounds known ...
US8771787B2 - Ink for digital offset printing applications
- Google Patents
The compounds have Hansen solubility parameters as described herein, and the resulting ink composition is both compatible with ... An ink composition useful for digital offset printing applications comprises a colorant and a plurality of curable compounds. ... PSGCQDPCAWOCSH-BREBYQMCSA-N [(1R,3R,4R)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] prop-2-enoate Chemical compound C1C[C@@]2(C)[ ... IAXXETNIOYFMLW-UHFFFAOYSA-N (4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl) 2-methylprop-2-enoate Chemical compound C1CC2(C)C(OC(=O) ...
Pesquisa | Portal Regional da BVS
... exhibits promising potential for the synthesis of disubstituted straight-shaped bicyclo[1.1.1]pentane (BCP) compounds by ... Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped Diphosphine Ligands. ... to trace an input compound back to reasonable starting materials through thermally allowed pericyclic reactions via product- ...
The pyrethrins and related compounds. Part XXXI: alkoxyimino-substituted esters. : Rothamsted Research
Isolation, characterisation and synthesis of an insecticidal tetramethyltetrahydrochromenedione-spiro-bicyclo[3.1.1] ... Fungicidal compounds (B) (WO 97/16970). H1 - Patents granted. Khambay, B. P. S. and Batty, D. 1997. Fungicidal compounds (B) ( ... Pesticidal compounds (WO/9621354). H1 - Patents granted. Khambay, B. P. S. and Batty, D. 1996. Pesticidal compounds (WO/9621354 ... The pyrethrins and related compounds. Part VII. New pyrethrin-like compounds with ester and ketonic groups in alcoholic side ...
Cyclohexanes (definition)
Bicyclo Compounds *Cyclohexanes. J Org Chem. 2007 Jan 19;72(2):532-7 1,2-. dibromo-. 4-. (1,2-. dibromoethyl)cyclohexane 0 * ... SLV320 compound 0 *Cyclohexanes *Heterocyclic Compounds, 2-Ring. Br J Pharmacol 2007 Aug;151(7):1025-32 1-. ethynylcyclohexene ... Cyclohexanes *Epoxy Compounds. Org Lett. 2010 Feb 5;12(3):620-3 1,2,4,5-. tetraimino-. 3,6-. diketocyclohexane 0 *Cyclohexanes. ... Acetates *Cyclohexanes *Sulfhydryl Compounds. Eur J Pharmacol. 2007 Feb 5;556(1-3):207-14 1,6-. dichlorohexane 0 *Cyclohexanes. ...
MH DELETED MN ADDED MN
Bicyclo Compounds, Heterocyclic D2.455.426.100.80.85 D3.438.260 D4.75.80.875 (Replaced for 2016 by Bridged Bicyclo Compounds, ... Heterocyclic Compounds with 4 or More Rings D3.549 D3.633.400 (Replaced for 2016 by Heterocyclic Compounds, 4 or More Rings) ... Heterocyclic Compounds, 2-Ring D3.438 D3.633.100 Heterocyclic Compounds, 3-Ring D3.494 D3.633.300 Heterotrophic Processes ... Pyrvinium Compounds D3.438.810.824.700 D3.633.100.810.824.700 Quality of Life N6.850.505.400.425.837 Quercetin D3.438.150.266. ...
EN
4 Ene
4 30 Which compound is a member of the alkane series 1 C2H6 3 C4H6 2 C3H6 4 C6H6 31 Which of the following compounds has the ... Bicyclo 3 1 0 hex 2 ene , 4 , 6 dichloro , 1alpha, 4alpha, 5alpha, 6alpha 9CI CAS 68241 70 3Aprueba los Grupos de Consumo que ... Compound classes 🙘4 butene 1, 2, 7 tri ene oct 5 ynemay be answer of this question not sure but u check it manjeet26 manjeet26 ... Compound classes 🙘File Trans Non 4 ene structure svg Size of this PNG preview of this SVG file 345 48 pixels Other resolutions ...
US Patent for Monocyte chemoattractant protein-1 inhibitor compounds Patent (Patent # 6,953,809 issued October 11, 2005) -...
The invention concerns the use of a compound of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings ... Bicyclo Ring System Which Is Indole (including Hydrogenated) (546/277.4); The Five-membered Hetero Ring Contains One Double ... Compound X 10 Lactose Ph.Eur 488.5 Magnesium 1.5 (e) Injection I (50 mg/ml) Compound X 5.0% w/v 1 M Sodium hydroxide solution ... "Compound X"), for therapeutic or prophylactic use in humans:. (a) Tablet I mg/tablet Compound X. 100 Lactose Ph.Eur 182.75 ...
bridged compounds,bridged bicyclic compounds
... high quality bridged compounds and bridged bicyclic compounds,choose our products,Chemenu is the leading factory & company. ... Aliphatic Chain Compounds Borates Boronic Acids and Esters Bridged Compounds Catalysts and Ligands Fluorinated Compounds Spiro ... Bridged Compounds. Bridged ring compound refers to any two rings in the compound, which share two non-directly connected carbon ... Bridged ring compounds are a class of organic compounds that are widely present in nature and usually have important ...
Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer. - NextBio...
Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer. Renyu Guo, Yu- ... Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer. Journal of the ... Here a new strategy for the synthesis of bicyclo[2.1.1]hexanes is described. These bicycles are significant because they have ... The process involves sensitization of a bicyclo[1.1.0]butane followed by cycloaddition with an alkene. The scope and ...
Patents 5280055 - 5280309
ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES : : Azo : Fiber- or substrate-reactive azo compound : Formazan containing ... Bicyclo ring system having the five-membered hetero ring as one of the cyclos (e.g., octahydroindoles, etc.) : The bicyclo ring ... ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES : : HETEROCYCLIC CARBON COMPOUNDS CONTAINING A HETERO RING HAVING ... ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES : : HETEROCYCLIC CARBON COMPOUNDS CONTAINING A HETERO RING HAVING ...
2,2-Dimethylhexanoic acid
(813-72-9)
- Chemical Safety, Models, Suppliers, Regulation, and Patents -...
4-(Ethoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid (834-50-4) 1 alternate name ... Similar Compounds. 1-Methylcyclopentanecarboxylic acid (5217-05-0, 110378-86-4) 1 alternate name ... Bicyclo[2.2.2]octane-1,4-dicarboxylic acid (711-02-4) 1 alternate name ... Bicyclo[2.2.2]octane-1-carboxylic acid (699-55-8) 1 alternate name ...
About Gaussian 16 | Gaussian.com
Organophosphorous compounds are commonly used as pesticides (among many other applications). These compounds adversely affect ... The Baeyer-Villiger oxidation of (+)-(1R,5S)-bicyclo[3.3.1]nonane-2,7-dione has four possible keto-lactone products. VCD ... These compounds were modeled with the B3LYP/aug-cc-pVDZ model chemistry, using the Stuttgart/Dresden ECP and [7s 6p 5d 3f] ... Compounds whose chemistry occurs within a protein environment. In such cases, ONIOM is needed both because of the sheer size of ...
Search Results
Gancel, A.-L.; Ollé, D.; Ollitrault, P.; Luro, F.; Brillouet, J.-M., Leaf and peel volatile compounds of an interspecific ... Bicyclo[3.1.1]heptan-3-one, 2,6,6-trimethyl-, (1α,2β,5α)- (C10H16O) ... Bicyclo[3.1.0]hex-2-ene, 2-methyl-5-(1-methylethyl)- (C10H16) ... Bicyclo[3.1.0]hexane, 4-methylene-1-(1-methylethyl)- (C10H16) ...
Progress in Chemical and Biochemical Research - Editorial Board
Benzylation of aromatic compounds catalyzed by 3-methyl-1-sulfonic acid imidazolium tetrachloroaluminate and silica sulfuric ... Friedel-Crafts alkylation of 4-hydroxycoumarin over silica-bonded 1,4-diaza-bicyclo[2.2.2] octane-sulfonic acid chloride as ... These compounds display antibacterial activity with high levels of inhibitory potency against Gram-negative bacteria ... A solvent-free protocol for facile condensation of indoles with carbonyl compounds using silica chloride as a new, highly ...
Biosynthesis and Regulation of Antioxidant Flavonolignans in Milk Thistle | IntechOpen
These are the structural isomers of the compounds mentioned above. Among these 3 compounds, only silychristin was characterized ... thus creating a bi-cyclo structure [79]. Subsequently, an intramolecular attack of an enolate on quinone methide ( ... They can catalyze the oxidation of a wide variety of organic compounds using hydrogen peroxide (H2O2) [82]. The most studied ... These compounds were separated by column chromatography on silica gel, reverse phase HPLC, followed by recrystallization [48]. ...
Enantioselective Cu-catalyzed double hydroboration of alkynes to access chiral gem-diborylalkanes | Nature Communications
Optically enriched 1,1-diboron compounds are significantly underdeveloped because of the paucity of the straightforward ... The development of chiral bis(boryl) alkanes, especially optically enriched 1,1-diboron compounds, has been greatly inhibited ... Catalytic undirected borylation of tertiary C-H bonds in bicyclo[1.1.1]pentanes and bicyclo[2.1.1]hexanes. 27 March 2023 ... K.L., W.D., S.W., X.H. & X.L. helped collecting some new compounds and analyzing the data. P.Y. and J.L. performed the DFT ...
Gremaud Ludovic - Professeur HES associé - Suchen Sie nach Mitarbeiter - HES-SO
The compounds were synthesized in six steps where the key steps involved a blue LED mediated intramolecular cyclopropanation of ... Construction of Bicyclo[3.2.1]octanes with Four Stereogenic Centers by Organocatalytic Domino Michael/Aldol Reaction ... As an application compounds bearing azepino[4, 5-b]indole and spiropiperidino indole building blocks were synthesized from the ... As an application compounds bearing azepino [4,5-b]indole and spiropiperidino indole building blocks were synthesized from the ...
Angewandte Chemie International Edition | Scholars@Duke
Vauthey Research Group - Group Members
Total synthesis of natural terpenoids containing the bicyclo[5.3.0]decane skeleton Thursday 27 April 2006 16:30 lecture theatre ... The Reduction of Aromatic Compounds: Mechanism, Stereochemistry and Application Friday 24 February 2006 10:00 lecture theatre. ... Application of Arene Chromium Tricarbonyl Complexes to the Synthesis of Biologically Active Compounds Thursday 3 November 2005 ...
Publication Year: 2017 / Subject: chemical structure / Subject term: chemical structure / Text Availability: Citation in PubAg ...
... and appropriate organolithium compounds (RLi). As BnR2MgLi complexes are more nucleophilic than the parent Grignard compound ... Serendipitous findings of an acid mediated skeletal rearrangement of bicyclo-β-ketoester having cyclopropyl ring to access ... These compounds were readily prepared by using Suzuki-Miyaura cross-coupling as a key step. The 4-cyano, 4-methoxycarbonyl, and ... These compounds have an important role in plant development, triggering direct and indirect responses when harmed to induce ...
Synthesis3
- Our program in natural products/bio-organic chemistry is concerned with the synthesis and biological evaluation analogs of plant derived phenolic compounds known to be inhibitors of tumor formation. (bgsu.edu)
- Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer. (illumina.com)
- An intermediate useful for the synthesis of some compounds of the invention involves the preparation of the tert-butyl ester indolobenzazepine shown in Scheme 3. (newdrugapprovals.org)
Hexane1
- In this study, (N)-Methanocarba (bicyclo[3.1.0]hexane)-adenosine derivatives were probed for sites of charged sulfonate substitution, which precludes diffusion across biological membranes, e.g. blood brain barrier. (nih.gov)
Inhibitors2
- No. 5,272,145 disclose indole compounds as inhibitors of leukotriene biosynthesis with a benzyl moiety attached to the nitrogen of the indole ring. (justia.com)
- Similar compounds are also disclosed in WO 93/20078 (severe head injury), EP 0186367 (antiallergy), EP 0275667 (inhibitors of leukotriene biosynthesis), U.S. Pat. (justia.com)
Organic1
- Bridged ring compounds are a class of organic compounds that are widely present in nature and usually have important physiological activities, such as the famous anticancer drug paclitaxel and antimalarial drug artemisinin. (chemenu.com)
Atoms1
- Bridged ring compound refers to any two rings in the compound, which share two non-directly connected carbon atoms, and are classified into bicyclic hydrocarbons, tricyclic hydrocarbons, tetracyclic hydrocarbons, etc. (chemenu.com)
Hypoxia1
- Taken together, our results suggest that GP-14 acts as a neuroprotective agent to protect against neuronal damage induced by severe hypoxia and it is a promising compound for the development of neuroprotective drugs. (bvsalud.org)
Involves1
- The process involves sensitization of a bicyclo[1.1.0]butane followed by cycloaddition with an alkene. (illumina.com)
Species2
- Gaussian 16's models can be applied to both stable species and compounds which are difficult or impossible to observe experimentally, whether due to their nature (e.g., toxicity, combustibility, radioactivity) or their inherent fleeting nature (e.g., short-lived intermediates and transition structures). (gaussian.com)
- Thus, rational design methods, based on A3AR homology models, successfully predicted sites for sulfonate incorporation on (N)-methanocarba nucleosides developing compounds with species-independent A3 affinity, useful in delineating adenosine's CNS vs. peripheral actions. (nih.gov)
Invention3
- The invention concerns the use of a compound of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, in the treatment of a disease or condition mediated by monocyte chemoattractant protein-1 (MCP-1). (justia.com)
- The present invention relates to anti-inflammatory compounds that act via inhibition of Monocyte Chemoattractant Protein-1 (MCP-1) and especially MCP-1 inhibitor compounds that contain an indole moiety. (justia.com)
- The present invention is based on the discovery of a class of compounds containing an indole moiety which have useful inhibitory activity against MCP-1. (justia.com)
Chemical2
- A wide variety of methods makes Gaussian 16 applicable to a broad range of chemical conditions, problem sizes and compounds. (gaussian.com)
- Starting from the fundamental laws of quantum mechanics, Gaussian 16 predicts the energies, molecular structures, vibrational frequencies and molecular properties of compounds and reactions in a wide variety of chemical environments. (gaussian.com)
Synthetic2
- The development of chiral bis(boryl) alkanes, especially optically enriched 1,1-diboron compounds, has been greatly inhibited by the lack of direct synthetic protocols. (nature.com)
- However, chiral bis(boryl) compounds are underdeveloped due to the paucity of straightforward synthetic strategies. (nature.com)