Bicyclo CompoundsBicyclo Compounds, Heterocyclic: A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.ImidesCyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Indole Alkaloids: Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Adenosine A3 Receptor Agonists: Drugs that selectively bind to and activate ADENOSINE A3 RECEPTORS.Adenosine A3 Receptor Antagonists: Compounds that selectively bind to and block the activation of ADENOSINE A3 RECEPTORS.Prenylation: Attachment of isoprenoids (TERPENES) to other compounds, especially PROTEINS and FLAVONOIDS.Methyl n-Butyl Ketone: An industrial solvent which causes nervous system degeneration. MBK is an acronym often used to refer to it.NorbornanesRhodium: Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)Cyclooctanes: A group of compounds with an 8-carbon ring. They may be saturated or unsaturated.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.Receptor, Adenosine A3: A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.KetonesNucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)CyclopropanesHexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Spectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)BornanesMolecular Conformation: The characteristic three-dimensional shape of a molecule.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.

Drug-protein binding and blood-brain barrier permeability. (1/549)

The permeability surface area (PS) product, an index of permeability of the blood-brain barrier (BBB), was measured by using the in situ perfusion method. In the cerebral circulation, the fraction of drug that permeates into the brain through the BBB is not only the unbound fraction but also the fraction dissociated from the protein in the perfusate. The sum of these two fractions, the apparent exchangeable fraction, was estimated by fitting the parameters of the BBB permeability under the condition of varying BSA concentrations in the perfusate. The unbound fraction of drugs in a buffer containing 0.5 mM BSA was measured by using the ultrafiltration method in vitro, and the apparent exchangeable fraction was measured in vivo by using the intracarotid artery injection method. The apparent exchange fraction was 100% for S-8510, 96.5% for diazepam, 90.9% for caffeine, 38.3% for S-312-d, 33.1% for propranolol, and 6.68% for (+)-S-145 Na, and each of these was higher than the corresponding unbound fraction in vitro in all drugs. The apparent exchangeable fractions, for example, were 8 times higher for diazepam and 38 times for S-312-d than the unbound fractions in vitro. The apparent exchangeable fraction of drugs was also estimated from the parameters obtained with the perfusion method. Because drugs can be infused for an arbitrary length of time in the perfusion method, substances with low permeability can be measured. The apparent exchangeable fractions obtained with this method were almost the same as those obtained with the intracarotid artery injection method.  (+info)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (2/549)

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.  (+info)

Isolation and structural determination of a novel bicyclic taxane diterpene from needles of the Chinese yew, Taxus mairei. (3/549)

A novel bicyclic taxane diterpene with a rare 12-membered ring was isolated from needles of the Chinese yew, Taxus mairei, and its structure was established as (3E, 8E)-2 alpha, 7 beta, 9, 10 beta, 13 alpha, 20-hexaacetoxy-5(2'-acetoxy-cinnamoyloxy)-3,8-secotaxa -3,8,11-triene (1) with the help of 1D and 2D NMR data. The relative stereochemistry was deduced from a NOESY experiment.  (+info)

Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury. (4/549)

We examined the effects of modulating group II metabotropic glutamate receptors (mGluRs) on traumatic neuronal injury using both in vitro and in vivo models. Treatment with various selective group II mGluR agonists significantly decreased lactate dehydrogenase release, a marker of cell death, after traumatic injury to rat neuronal-glial cultures; injury-induced increases in cyclic AMP and glutamate levels were also significantly reduced by a group II agonist. The neuroprotective effects of group II agonists were markedly attenuated by coadministration of a group II antagonist or a membrane-permeable cyclic AMP analog and were additive to those provided by an N-methyl-D-aspartate receptor antagonist or a selective group I mGluR antagonist. Administration of a group II mGluR agonist 30 min after lateral fluid percussion-induced brain injury in rats significantly improved subsequent behavioral recovery as compared with vehicle-treated controls. Together these studies indicate that group II mGluR agonists protect against traumatic neuronal injury by attenuating glutamate release and cAMP levels and suggest a potential role for these agents in the treatment of clinical neurotrauma.  (+info)

Endothelium-derived contracting factor in carotid artery of hypertensive Dahl rats. (5/549)

The present study is designed to investigate whether acetylcholine (ACh) elicits an endothelium-derived contracting factor (EDCF) and whether it contributes to decreased relaxant response induced by ACh in Dahl rats. Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a 0.4% NaCl or an 8% NaCl diet for 4 weeks. High sodium intake significantly increased blood pressure in DS rats but not in DR rats. The carotid rings were suspended for isometric tension recording. ACh caused an endothelium-dependent contraction in carotid rings from hypertensive DS rats but not from normotensive Dahl rats. Atropine, indomethacin, SQ29548, or ONO-3708 (prostaglandin H(2) [PGH(2)]/thromboxane A(2) [TXA(2)] receptor antagonist) abolished ACh-induced contraction, and OKY-046 (inhibitor of TXA(2) synthetase) partially attenuated the contraction. High sodium intake significantly enhanced contraction evoked by U46619, a PGH(2)/TXA(2) receptor agonist, in both DS and DR rats. In contrast, ACh-induced relaxation was significantly depressed in the rings from hypertensive DS rats, and ONO-3708 partially improved the depressed relaxation. Administration of ONO-8809 (an orally active PGH(2)/TXA(2) receptor antagonist; 30 micrograms per body per day) for 4 weeks neither reduced blood pressure nor improved the depressed ACh-induced relaxation in hypertensive DS rats. These results suggest that ACh causes release of EDCF in carotid rings of hypertensive DS rats, which is likely to be PGH(2) and TXA(2). The EDCF contributed in part to the depressed ACh-induced relaxation.  (+info)

Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes. (6/549)

Type II pneumocytes, which synthesize, store, and secrete pulmonary surfactant, require exogenous fatty acids, in particular palmitic acid, for maximum surfactant synthesis. The uptake of palmitate by type II pneumocytes is thought to be protein mediated, but the protein involved has not been characterized. Here we show by RT-PCR and Northern blot analysis that rat type II pneumocytes express the mRNA for fatty acid translocase (FAT/CD36), a membrane-associated protein that is known to facilitate the uptake of fatty acids into adipocytes. The deduced amino acid sequence from rat type II pneumocytes reveals 98% identity to the FAT/CD36 sequence obtained from rat adipocytes. The uptake of palmitate by type II pneumocytes follows Michaelis-Menten kinetics (Michaelis-Menten constant = 11.9 +/- 1.8 nM; maximum velocity = 62.7 +/- 5.8 pmol. min(-1). 5 x 10(5) pneumocytes(-1)) and decreases reversibly under conditions of ATP depletion to 35% of control uptake. Incubation of cells at 0 degrees C inhibited the uptake of palmitate almost completely, whereas depletion of potassium was without effect. Preincubation of the cells with bromobimane or phloretin decreases the uptake of palmitate significantly as does preincubation with sulfo-N-succinimidyl oleate, the specific inhibitor of FAT/CD36 (C. M. Harmon, P. Luce, A. H. Beth, and N. A. Abumrad. J. Membr. Biol. 121: 261-268, 1991). From these data, we conclude that FAT/CD36 is expressed in type II pneumocytes and mediates the uptake of palmitate in a saturable and energy-dependent manner. The data suggest that the uptake process is independent of the formation of coated pits and endocytotic vesicles.  (+info)

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1. (7/549)

Extracts of Hypericum perforatum (St. John's Wort) are widely used for the treatment of depressive disorders and are unspecific inhibitors of the neuronal uptake of several neurotransmitters. Previous studies have shown that hyperforin represents the reuptake inhibiting constituent. To characterize the mechanism of serotonin reuptake inhibition, kinetic analyses in synaptosomes of mouse brain were performed. Michaelis-Menten kinetics revealed that hyperforin (2 microM) induces a decrease in V(max) by more than 50% while only slightly decreasing K(m), indicating mainly noncompetitive inhibition. By contrast, citalopram (1 nM) leads to an elevation of K(m) without changing V(max). Monensin, a Na(+)/H(+) exchanger, showed similar properties as hyperforin (decrease of V(max) without changing K(m)). Compared with classical antidepressants, such as selective serotonin reuptake inhibitors and tricyclic antidepressants, hyperforin is only a weak inhibitor of [(3)H]paroxetine binding relative to its effects on serotonin uptake. As monensin decreases serotonin uptake by increasing Na(+)/H(+) exchange, we compared the effects of hyperforin and monensin on the free intracellular sodium concentration ([Na(+)](i)) in platelets by measuring 1,3-benzenedicarboxylic acid, 4,4'-[1,4,10-trioxa-7, 13-diazacyclopentadecan-7,13-diylbis(5-methoxy-6, 2-benzofurandiyl)]bis-, tetraammonium salt (SBFI/AM) fluorescence. Both drugs elevated [Na(+)](i) over basal levels, with a maximal [Na(+)](i) of 69 +/- 16.1 mM (50 microM hyperforin) and 140 +/- 9.1 mM (10 microM monensin). Citalopram at concentrations relevant for [(3)H]serotonin uptake inhibition had no effect on [Na(+)](i). Although the mode of action of hyperforin seems to be associated with elevated [Na(+)](i) similar to those levels found with monensin, the molecular mechanism might be different, as even at high concentrations, hyperforin does not elevate free intracellular sodium concentration ([Na(+)](i)) up to the extracellular level, as monensin does. Hyperforin represents the first substance with a known preclinical antidepressant profile that inhibits serotonin uptake by elevating [Na(+)](i).  (+info)

Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist. (8/549)

A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL.  (+info)

*Polyquinane

The simplest member is the bicyclic compound bicyclo[3.3.0]octane. Other members are triquinacene and dodecahedrane. The ... and also as part of a failed attempt to synthesize the then-elusive and much-coveted compound dodecahedrane. Unlike the related ... compound triquinacene (tricyclo[5.2.1.-04,10]deca-2,5,8-triene) is the second member of a family of polyquinenes. It was ...

*Bicyclic molecule

Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. In between the ... Therefore, fused bicyclic compounds have a "0" included in the brackets. For example, decalin is named bicyclo[4.4.0]decane. ... An example of a spirocyclic compound is the photochromic switch spiropyran. In fused bicyclic compounds, two rings share two ... When naming simple fused bicyclic compounds, the same method as for bridged bicyclic compounds is applied, except the third ...

*Brevianamide

Structurally similar to paraherquamides, they are a small class compounds that contain a bicyclo[2.2.2]diazoctane ring system. ...

*Dimethyl fumarate

With this reaction, compounds with bicyclo skeletons can be synthesized, e.g. a diester with a norbornene (bicyclo[2.2.1] ... The compound (and its metabolite, monomethyl fumarate) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway ... As a α,β-unsaturated electrophilic compound, dimethyl fumarate is rapidly attacked by the detoxifying agent glutathione (GSH) ... Boyland, E; Chasseaud, LF (1967). "Enzyme-catalysed conjugations of glutathione with unsaturated compounds". The Biochemical ...

*Decalin

... (decahydronaphthalene, also known as bicyclo[4.4.0]decane), a bicyclic organic compound, is an industrial solvent. A ...

*Norbornane

... (also known as bicyclo[2.2.1]heptane) is an organic compound and a saturated hydrocarbon with chemical formula C7H12 ... and is a bridged bicyclic compound. The compound is a prototype of a class of strained bicyclic hydrocarbons. The compound was ... It is a crystalline compound with melting point 88 °C. The carbon skeleton is derived from cyclohexane ring with a methylene ... das Bicyclo-[1.2.2]-heptan, und die stereoisomeren Norborneole". Naturwissenschaften. 22: 171. doi:10.1007/BF01496254. ...

*Bicyclopentane

... may refer to: Bicyclo[1.1.1]pentane Bicyclo[2.1.0]pentane, or Housane Bicyclopentyl Bicyclic compound ...

*Iptycene

An iptycene is an aromatic compound composed of varying number of arene subunits bound to bicyclo-octatriene brighead system. ...

*Barrelene

... is a bicyclic organic compound with chemical formula C8H8 and systematic name bicyclo[2.2.2]octa-2,5,7-triene. First ... Synthesis of Substituted Bicyclo[2.2.2]octatrienes Michael W. Wagaman, Erika Bellmann, Michèle Cucullu, and Robert H. Grubbs J ... Triptycenes, with the alkene groups part of an arene, are related compounds. It is also a starting material for many other ... Due to its unusual molecular geometry the compound is of considerable interest to theoretical chemists. ...

*Homoaromaticity

Instead, the group proposed the structure of the bicyclo[5.1.0]octadienyl compound, theorizing that the cyclopropane bond ... Similarly, a substituted bicyclo[3.2.1]octa-3,6-dien-2-yl cation (the 2-(4'-Fluorophenyl) bicyclo[3.2.1]oct-3,6-dien-2-yl ... These anionic compounds are often prepared from their neutral parent compounds through lithium metal reduction. 1,2- ... Just as aromatic compounds exhibit exceptional stability, antiaromatic compounds, which deviate from Huckel's rule and contain ...

*Bicyclo(1.1.1)pentane

Bicyclo[1.1.1]pentane is an organic compound, the simplest member of the bicyclic bridged compounds family. It is a hydrocarbon ... Bicyclo[1.1.1]pentane is a highly strained molecule. Kenneth Wiberg and Frederick Walker used bicyclo[1.1.1]pentane to make [ ...

*List of chemical compounds with unusual names

"Bicyclo [2.2.2]octa-2,5,7-triene (barrelene), a unique cyclic six electron pi system". Journal of the American Chemical Society ... Verbrugge, P. A. (1977). "Unusual organic compounds. XXIV. Compounds with the formula (CH)n. (d). Synthesis of cubane, (CH)8; ... Monk, Felonious (13 April 2006). "Chemical Cock-ups: A Story of How Not to Name a Chemical Compound". h2g2: The guide to life, ... Chemical nomenclature, replete as it is with compounds with complex names, is a repository for some very peculiar and sometimes ...

*Vanda tessellata

A compound decoction of this root is administered in cases of Hemiplegia as some Indian physicians consider it useful in ... 7-tri methyl bicyclo [2.2.1] heptane) has been found in the orchid in 2013. The plant has an alkaloid, a glucoside, tannins, β- ... A novel aphrodisiac compound from an orchid that activates nitric oxide synthases ' International Journal of Impotence Research ... sitosterol, γ-sitosterol and a long chain aliphatic compound, fatty oils, resins and colouring matters. Roots contain ...

*Housane

This compound is prepared in several steps starting with cyclopentadiene. P. G. Gassman, K. T. Mansfield "Bicyclo[2.1.0]pentane ... Housane or bicyclo[2.1.0]pentane is a saturated cycloalkane with the formula C5H8. It is a colorless volatile liquid. It was ...

*List of MeSH codes (D02)

... bicyclo compounds MeSH D02.455.426.100.080.085 --- bicyclo compounds, heterocyclic MeSH D02.455.426.100.080.100 --- biperiden ... trialkyltin compounds MeSH D02.691.850.900.910 --- triethyltin compounds MeSH D02.691.850.900.950 --- trimethyltin compounds ... mustard compounds MeSH D02.455.526.728.468 --- mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455 ... bephenium compounds MeSH D02.092.877.096.333 --- bretylium compounds MeSH D02.092.877.096.333.150 --- bretylium tosylate MeSH ...

*Category:Organic compound stubs

Bicyclo(2.2.1)heptane-2-carbonitrile. *Biotin hydrazide. *2,3-Bis(acetylmercaptomethyl)quinoxaline ... This category is for stub articles relating to organic compounds. You can help by expanding them.. To add an article to this ... Pages in category "Organic compound stubs". The following 200 pages are in this category, out of approximately 1,151 total. ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Organic_compound_stubs&oldid=734103263" ...

*Transition state

One demonstration of this principle is found in the two bicyclic compounds depicted below. The one on the left is a bicyclo[2.2 ... Rickert Reaction in the Structures of Bicyclo[2.2.2]octadiene and Bicyclo[2.2.2]octene Derivatives". The Journal of Organic ... Compared to the compound on the right (which, lacking an alkene group, is unable to give this reaction) the bridgehead carbon- ... For these two compounds the prediction holds up based on X-ray crystallography. One way that enzymatic catalysis proceeds is by ...

*Norcarane

... , or bicyclo[4.1.0]heptane, is a colorless liquid. It is an organic compound prepared using the Simmons-Smith reaction ...

*Exo-Norborneol

The perdeuteration of bicyclo[2.2.1]heptanes PDF Stille, J. K.; Sonnenberg, Fred M. (1966). "The Reaction of endo- and exo-2- ... Commercially available, this compound may be prepared by the reaction of norbornene with formic acid, followed by hydrolysis of ... Collective Volume, 5 Reaction of organic compounds under high temperature - dilute acid (HTDA) conditions. III. ...

*Ladderane

Both routes leverage a small [2]-ladderene building block bicyclo[2.2.0]hexene prepared by a Ramberg-Bäcklund reaction. The ... Trans-ladderanes have not been synthesized due to the ring strain in these compounds. The second stereochemical relationship ... Various synthetic methods have been used for the laboratory synthesis of ladderane compounds. The three major approaches are (1 ... Elimination of H-Br and addition of an organozinc compound installs the alkyl alcohol. A hydrazine-mediated deoxygenation ...

*Twistane

... (IUPAC name: tricyclo[4.4.0.03,8]decane) is an organic compound with the formula C10H16. It is a cycloalkane and an ... The original 1962 method was based on a bicyclo[2.2.2]octane framework. A 1967 publication concerned a intramolecular aldol ... The compound was first reported by Whitlock in 1962. Twistane has been synthesized in a variety of ways. ...

*Tetranitratoxycarbon

As an oxygen-rich compound of carbon and nitrogen, it is predicted to have explosive properties,[2] but to be too thermally ... The all-carbon analog (bicyclo[1.1.1]pentane) and other elemental variations of this ring structure have been synthesized. ... The nitratoxycarbon functional group itself has yet to be observed in any chemical compound. Computational chemistry studies ... and nitrate compounds and their potential as high energy materials". Computational and Theoretical Chemistry. 979: 33-37. doi: ...

*1.1.1-Propellane

The compound is highly unstable, and at 114 °C it will spontaneously isomerize to 3-methylidenecyclobutene with a half-life of ... 2.2.2]Propellane Bicyclo(1.1.1)pentane which lacks a bond between the bridgehead carbons. "Houben-Weyl Methods of Organic ... The compound 1,3-dehydroadamantane, which can be viewed as a bridged [1.3.3]propellane, also polymerizes in a similar way. [ ... 1.1.1]Propellane is an organic compound, the simplest member of the propellane family. It is a hydrocarbon with formula C5H6 or ...

*List of extremely hazardous substances

... ketone Bitoscanate Boron trichloride Boron trifluoride Boron trifluoride compound with methyl ether (1:1) Bromadiolone Bromine ... Benzotrichloride Benzyl chloride Benzyl cyanide Bicyclo(2.2.1)heptane-2-carbonitrile Bis(chloromethyl) ...

*Dewar benzene

... or bicyclo[2.2.0]hexa-2,5-diene is a bicyclic isomer of benzene with the molecular formula C6H6. The compound is ... The compound itself was first synthesized in 1962 as a tert-butyl derivative and then as the unsubstituted compound by Eugene ... The compound has nevertheless considerable strain energy and reverts to benzene with a chemical half-life of two days. This ... Bicyclo[2.2.0]hexa-2,5-dienes (Dewar benzenes)". J. Am. Chem. Soc. 93 (23): 6092-6101. doi:10.1021/ja00752a021. Hoffmann, Roald ...

*Maprotiline

... is a tetracyclic compound and is grouped with the TeCAs. Its chemical name is N-methyl-9,10-ethanoanthracen-9(10H)- ... This results in it having a unique three-dimensional central ring (a bicyclo[2.2.2]octane or 1,4-endoethylenecyclohexane ring) ... Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). "Pharmacological profile of antidepressants and related compounds at ... and being a tetracyclic rather than a tricyclic compound. However, it could also or alternatively be considered to be a ...

*Reposal

"Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488-1493. PMID ... Reposal, 5-Ethyl-5-(bicyclo(3.2.1)octenyl)barbituric acid Farmakoinformacioni podaci ...

*Endo-Norborneol

The perdeuteration of bicyclo[2.2.1]heptanes PDF J. K. Stille, and Fred M. Sonnenberg (1966). "The Reaction of endo- and exo-2- ... Exo-Norborneol (+)-endo-2-Norborneol at Sigma-Aldrich endo-Norborneol MSDS Reaction of organic compounds under high temperature ...
BICYCLO(2.2.2)OCTANE-2-METHYLAMINE, N,N-DIMETHYL-3-PHENYL-, HYDROCHLORIDE, (E)- | C17H26ClN | CID 40537 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
95685-44-2 - PEHOHEDRAIXEOC-UHFFFAOYSA-N - Bicyclo(3.2.1)octane-3-carboxamide, 3-ethyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki , 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from rat cortex and pituitary. Systemically administered CP-154,526 antagonizes the stimulatory effects of exogenous CRF on plasma ACTH, locus coeruleus neuronal firing and startle response amplitude. Potential anxiolytic activity of CP-154,526 was revealed in a fearpotentiated startle paradigm. These data are presented in the context of clinical findings, which suggest that CRF is hypersecreted in certain pathological states. We propose that a CRF antagonist such as CP-154,526 could affirm the role of CRF in certain psychiatric diseases and may be of significant value in the treatment of these disorders.. ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 79530-86-2(Piperazine, 1-bicyclo[3.1.0]hex-3-yl-4-methyl-, (1-alpha-,3-ba-,5-alpha-)- (9CI)),please inquire us for 79530-86-2(Piperazine, 1-bicyclo[3.1.0]hex-3-yl-4-methyl-, (1-alpha-,3-ba-,5-alpha-)- (9CI)).
The IUPHAR/BPS Guide to Pharmacology. 3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Structure, properties, spectra, suppliers and links for: 3-[(1S,4S)-Bicyclo[2.2.1]hept-5-en-2-yl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfon.
40 CFR Part 180 [PP 0E3859/R2053; FRL-4772-7] Proposed Pesticide Tolerance for Procymidone AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. + ------------------------------------------------------------ SUMMARY: This document proposes to establish a tolerance for residues of the fungicide procymidone, N-(3,5-dichlorophenyl)1,2- dimethylcyclopropane-1,2-dicarboximide, in or on the raw agricultural commodity (RAC) wine grapes at 5.0 parts per million (ppm). This regulation to establish the maximum permissible level for residues of procymidone in or on wine grapes was requested in a petition submitted by Sumitomo Chemical Co., Ltd. DATES: Comments, identified by the document control number, [PP 0E3859/R2053], must be received on or before April 30, 1994. ADDRESSES: By mail, submit written comments to: Public Document and Freedom of Information Section, Field Operations Division (7506C), Office of Pesticide Programs, 401 M St., SW., Washington, DC 20460. In person, bring ...
Example 15) [(RS, 5SR, 6SR)-3-ethyl-6- (nitromethyl) bicyclo [3.2.0] hept-3-en-6-yl] ethyl acetate (racemic) Ethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] acetate (Racemate) [of 39] Diethyl [(RS, 5SR) -3-Ethylbicyclo [ 3.2.0] hept-3-en-6-ylidene] propanedioate (256.0 mg, 0.920 mmol) was dissolved in toluene (2.5 mL), was added DBU (152 mL), nitromethane (55 mL), at room temperature for 17 time it was stirred. After quenching with 1 M HCl (5 mL), and extracted three times with ethyl acetate (5 mL), and the resulting ethyl acetate solution was washed with saturated brine (5 mL). The solvent was evaporated under reduced pressure, as a pale yellow oily substance Diethyl [(1RS, 5SR, 6SR) -3-ethyl-6- (nitromethyl) bicyclo- [3.2.0] hept-3-en-6-yl] propanedioate was obtained (336.9 mg). The resulting Diethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] - Propanedioate a (336.9 mg) DMSO and (3.4 mL) It was dissolved in water (50 μL, 2.78 ...
Example 15) [(RS, 5SR, 6SR)-3-ethyl-6- (nitromethyl) bicyclo [3.2.0] hept-3-en-6-yl] ethyl acetate (racemic) Ethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] acetate (Racemate) [of 39] Diethyl [(RS, 5SR) -3-Ethylbicyclo [ 3.2.0] hept-3-en-6-ylidene] propanedioate (256.0 mg, 0.920 mmol) was dissolved in toluene (2.5 mL), was added DBU (152 mL), nitromethane (55 mL), at room temperature for 17 time it was stirred. After quenching with 1 M HCl (5 mL), and extracted three times with ethyl acetate (5 mL), and the resulting ethyl acetate solution was washed with saturated brine (5 mL). The solvent was evaporated under reduced pressure, as a pale yellow oily substance Diethyl [(1RS, 5SR, 6SR) -3-ethyl-6- (nitromethyl) bicyclo- [3.2.0] hept-3-en-6-yl] propanedioate was obtained (336.9 mg). The resulting Diethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] - Propanedioate a (336.9 mg) DMSO and (3.4 mL) It was dissolved in water (50 μL, 2.78 ...
4-Nitrophenyl bicyclo[4.1.0]heptane-7-carboxylate | C14H15NO4 | CID 579216 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule 2-[(1S,2R,3S,4R,5R)-2-(6-amino-2-chloro-purine-1,3,7-triium-9-yl)-3,4-dihydroxy-5-bicyclo[3.1.0]hexanyl]ethylphosphonic acid (C13H17ClN5O5P) from the PQR.
2-Methoxy-6-(5,6,6-trimethyl-2-bicyclo[2.2.1]heptanyl)phenol/ACM20201756 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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CASSCF and CASPT2 calculations have been carried out on some of the thermal rearrangements of bicyclo[2.1.0]pentene (BCP), bicyclo[4.1.0]hepta-2,4-diene (BCH ...
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Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate 843-59-4 route of synthesis, Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate chemical synthesis methods, Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate synthetic routes ect.
Role of hyperforin in diabetes and its associated hyperlipidemia in rats - hyperforin;diabetes;insulin;antihyperglycemic;antihyperlipidemic;antioxidant;
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The naked sugar (+)-(1R,4R)-7-oxabicyclo[2.2.1]hept-5-en-one ((+)-2) has been converted to D-lividosamine ((+)-i: 3-deoxy-D-glucosamine) and derivatives via (+)-2-chloro-2,3-dideoxy-5,6-O-iso-propylidene-D-arabino-hexono-1,4-lact one ((+)-33) and (4)-2-azido-2,3-dideoxy-5,6-O-isopropylidene-D-ribo-hexono-1,4-lactone ((+)-34) in a highly stereoselective fashion. Similarly, 2-acetamido-2,3-dideoxy-D-arabino-hexose and derivatives were derived from the naked sugar (-)-(1S,4S)-7-oxabicyclo[2.2.1]-hept-5-en-2-one ((-)-2) via the double hydroxylation of the C-C double bond in (-)-N-benzyl-N-[(1R,2S,4S)-6-bromo-7-oxabicyclo[2.2.1]hept-5-en-2-endo-y l]amine ((-)-40).. Keywords: Pure 7-oxabicyclo<2.2.1>hept-5-en-2-yl derivatives ; organic-synthesis ; d-glucosamine ; acid ; sugars ; efficient ; migration ; additions ; furan. Note: Univ lausanne,chim sect,2 rue barre,ch-1005 lausanne,switzerland.. ...
Water-soluble cyclic imide thione activated polyalkylene oxides having improved hydrolytic stability are disclosed. Methods of forming and conjugating the activated polyalkylene oxides with biologically active nucleophiles are also disclosed.
Article Biofilm carriers / MBBR carrier media and their respective diffusion depth. Within the biological wastewater treatment sector, it can increasingly be observed that biofilm carriers are applied in so-called Moving Bed Biofilm Reactors (MBBR). ...
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for (1S,4S)-2-phenyl-2,5-diazabicyclo[2.2.1]heptane (CAS No. 294177-33-6)
Pinene is another distinctive terpene and there are actually two different strains that are used.. Your CBD might contain either alpha-pinene or beta-pinene, although they are both derived from pine trees and the pleasant smell is unmistakable when it hits your nostrils.. The main benefits attached to both the alpha-pinene and beta-pinene is their anti-inflammatory properties. Pinene is also considered useful for people with respiratory issues such as asthma.. Love lavender?. The smell of lavender is very distinctive and is an aroma associated with calmness and relaxation.. Linalool is the terpene that is found in lavender and CBD products and other herbs enriched by it also include coriander, mint, and cinnamon. This particular compound is often used when the purpose is to reduce inflammation, help you to contend with arthritis, and help reduce the impact of seizures.. It might be suggested to you that if you use other herbs that contain linalool in addition to your chosen CBD product it could ...
In the current bid for synthetic efficiency, multiple bond-forming transformations are becoming a key concept in organic synthesis. In this context, domino protocols have become increasingly common in the synthesis of bicyclic systems. This tutorial review aims at providing a short but authoritative overview
7,7-dimethyl-5-oxobicyclo[2.2.1]hept-2-en-1-yl acetate - chemical structural formula, chemical names, chemical properties, synthesis references
Structure, properties, spectra, suppliers and links for: (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino).
Krystal JH, Abi-Saab W, Perry E, DSouza DC, Liu N, Gueorguieva R et al. (2005). Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology (Berl) 179: 303-309 ...
Materials. All tissue culture reagents were obtained from Invitrogen (Carlsbad, CA). G418 sulfate was obtained from Mediatech, Inc., (Herndon, VA). [3H]LY341495 (28.28 Ci/mmol) was obtained from American Radiolabeled Chemicals, Inc. (St Louis, MO). l-Glutamate, DCG-IV, l-AP4 [l-(+)-2-amino-4-phosphonobutyric acid], and LY341495 were obtained from Tocris (Ellisville, MO). Methotrexate was purchased from Calbiochem (La Jolla, CA). BINA was synthesized as described previously (Galici et al., 2006). The Calcium 3 Assay Kit was obtained from Molecular Devices (Sunnyvale, CA). The indicator dye fluo-4 was obtained from Invitrogen. Probenecid, dimethyl sulfoxide (DMSO), puromycin dihydrochloride, GDP, and guanosine 5′-3-O-(thio)triphosphate were purchased from Sigma-Aldrich, Inc., (St. Louis, MO). Unifilter-96 GF/B plates and MicroScint-20 were obtained from PerkinElmer Life and Analytical Sciences (Boston, MA). BioCoat poly-d-lysine 96-well culture plates were obtained from BD Biosciences Discovery ...
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0078] In a preferred embodiment of the method of the present invention the ring system formed by R1 and R2 is [0079] (i) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, spiro[3,3]heptyl, spiro[3,4]octyl, spiro[4,3]octyl, spiro[3,5]nonyl, spiro[5,3]nonyl, spiro[3,6]decyl, spiro[6,3]decyl, spiro[4,5]decyl, spiro[5,4]decyl, bicyclo[4.1.0]heptyl, bicyclo[3.2.0]heptyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl, bicyclo[5.1.0]octyl, bicyclo[4.2.0]octyl, bicyclo[5.3.0]decyl, octahydro-pentalenyl, octahydro-indenyl, decahydro-azulenyl, adamantly, or decahydro-naphthalenyl; optionally substituted 1 to 14 times, i.e. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 times, depending on the number of available valences with a substituent which is in each instance independently selected from the group consisting of halogen, in particular F, Cl, Br or I; --NO2; --CN; --OR6; --NR6R7; --COOR6; --CONR6R7; --NR8COR9; --NR8COR9; --NR8CONR6R7; --NR9SO2A; --COR6; ...
0033] Cyclic-olefin monomer which constitutes the foregoing resin has a structure indicated by a chemical equation 23, and examples of preferable monomer are, for example, bicyclo[2,2,1]hept-2-ene (norbornene), 5-methylbicyclo[2,2,1]hept-2-ene, 7-methybicyclo[2,2,1]hept-2-ene, 5-ethylbicyclo[2,2,1]hept-2-ene, 5-propylbicyclo[2,2,1]hept-2-ene, 5-n-butylbicyclo[2,2,1]hept-2-ene, 5-isobutylbicyclo[2,2,1]hept-2-ene, 1,4-dimethylbicyclo[2,2,1]hept-2-ene, 5-bromobicyclo[2,2,1]hept-2-ene, 5-chlorobicyclo[2,2,1]hept-2-ene, 5-fluorobicyclo[2,2,1]hept-2-ene, 5,6-dimethylbicyclo[2,2,1]hept-2-ene, dicyclopentadiene, tricyclopentadiene, tetracyclo[4,4,0,12.5,17.10]-3-dodecene, 5,10-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 2,10-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 11,12-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 2,7,9-trimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 9-ethyl-2,7-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, ...
ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [OPP-300225C; FRL-3886-3] RIN 207C-AB78 Pesticide Tolerance for Procymidone AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This document establishes a time-limited tolerance for residues of the fungicide procymidone, N-(3,5- dichlorophenyl)-l,2- dimethylcyclopropane l,2- dicarboximide, in or on the raw agricultural commodity (RAC) wine grapes grown prior to January 1, 1990, at 7.0 parts per million (ppm). Sumitomo Chemical Co., Ltd., petitioned EPA to establish a maximum permissible level for residues of procymidone on grapes. EFFECTIVE DATE: This regulation becomes effective April 26, 1991. ADDRESSES: Written objections, identified by the document control number, [OPP-300225C], may be submitted to: Hearing Clerk (A-110), Environmental Protection Agency, Room 3708, 401 M St.,SW., Washington, DC 20460. FOR FURTHER INFORMATION CONTACT: By mail: Susan Lewis, Product Manager (PM) 21, (H7505C), Registration Division ...
Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD.. Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA.. Group II metabotropic glutamate (mGlu) receptor agonists, including (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), have demonstrated efficacy in animal models of anxiety and schizophrenia, and LY354740 decreased anxiety in human subjects. Herein, we report the in vitro pharmacological profile and pharmacokinetic properties of another potent, selective, and structurally novel mGlu2/3 receptor agonist, (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039) and provide comparisons with LY354740. Similar to LY354740, LY404039 is a nanomolar potent agonist at recombinant ...
Find quality suppliers and manufacturers of 508208-63-7(1H-Pyrrolo[2,3-c]pyridine-5-carboxamide,N-2-azabicyclo[2.2.1]hept-6-yl-) for price inquiry. where to buy 508208-63-7(1H-Pyrrolo[2,3-c]pyridine-5-carboxamide,N-2-azabicyclo[2.2.1]hept-6-yl-).Also offer free database of 508208-63-7(1H-Pyrrolo[2,3-c]pyridine-5-carboxamide,N-2-azabicyclo[2.2.1]hept-6-yl-) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Hyperforin is a plant-derived compound that has been found useful in the treatment of depression. In fact, this phytochemical was shown to be superior to popular antidepressants such as Prozac. What is this natural compound extracted from St. Johns wort? How does it improve the symptoms of depression and what are the main studies to back its claim? How should it be used? Read on to find the answers to these questions.
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Fig. 3.Mean absolute and relative power spectra. The graphs show the effects of ketamine 30 mg/kg (KET), LY379268 3 mg/kg (LY), the vehicle (VEH) and co-administration of ketamine 30 mg/kg + LY379268 3 mg/kg (KET/LY) on the absolute (a) and relative (b) power spectra. For better graphical presentation, data are expressed per 1 Hz as the percent change of their corresponding baseline with ±SEM × 100 / mean power of the corresponding baseline. Thus, all baselines are represented by the X axis (the zero line). Significant differences of mean power within the whole spectral bands of each treatment compared to the vehicle are shown in the upper part of the figure (ANCOVA). The direction of change is indicated by arrows. The ketamine-induced increase of low-gammaand the decrease in delta and theta powerwere reversed by LY379268. The decrease in beta andhighpower in LY379268was also observed in the ketamine + LY379268 treated animals. *** indicates p b 0.001 for ketamine 30 mg/kg vs the vehicle. ‡‡‡
Get to know what is Pinene and earn about the effects and benefits of Pinene as the ban on marijuana is slowly but surely becoming a thing of the past.
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Creative-Proteomics offer cas 3615-44-9 D-manno-[UL-13C7]hept-2-ulose D-manno-[UL-13C7]heptulose. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
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... The chemical compound pinene is a bicyclic terpene (C10H16, 136.24 g/mol ) known as a monoterpene [1]. There are two structural isomers found in nature:
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Définitions de 1 2 nitrophenoxy octane, synonymes, antonymes, dérivés de 1 2 nitrophenoxy octane, dictionnaire analogique de 1 2 nitrophenoxy octane (anglais)
Chevrolet extends its reach into supercar territory with the new 2015 Z06. This bad boy gets its get up and go from an intensely powerful supercharged 625h...
Ross, B C, Chan, C, Cox, B, Evans, G L, Giblin, G M P, Lester, M G, McCarthy, A D, Procopiou, P A, Sareen, M, Sharratt, P J and Watson, N S (1993) The squalestatins: potent inhibitors of squalene synthase. In: 206th American Chemical Society National Meeting, August 22-27, 1993, Chicago, Illinois, USA. Full text not available from this repository ...
Searching for the factory supply st. johns wort extract hypericin,hypericum perforatum dry extract? Here we are. Longfu Biochemical is one of the leading herbal products manufacturers with wide expertise and experience. Welcome to wholesale the factory supply hot sale products from us.
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to neurological pathologies, such as epilepsy, but the precise mechanisms by which this feedback can occur remain incompletely understood. At one glutamatergic synapse, the Drosophila neuromuscular junction, a mutation in the group II metabotropic glutamate receptor gene (DmGluRA) increased motor neuron excitability by disrupting an autocrine, glutamate-mediated negative feedback. We show that DmGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo. Furthermore, glutamate application increases levels of phospho-Akt, a product of PI3K signaling, within motor nerve terminals in a DmGluRA-dependent manner. Finally, we show that PI3K increases both axon diameter and synapse number via the ...
DescriptionRecent investigations suggest that ligands such as steroids inhibit the binding of [35S] t-butylbicyclophosphorothionate ([35S] TBPS) to the convulsant site in the aminobutyric acid type A (GABAA) receptor complex. Currently, most interest is centered on ligands with [35S] TBPS displacement properties. Ligands binding to the GABAA receptor, block GABA-gated chloride ion flux in a non-competitive manner, resulting in convulsions. Traditionally, [35S] TBPS inhibition studies are measured using animal tests. Testing compounds, using rat tests, for potentially new ligands are costly and time-consuming. Therefore, developing computational models to predict potential [35S] TBPS displacement could provide many opportunities for the discovery and development of new ligands acting on the GABAA receptor convulsant site, resulting in the preventions of convulsions. In this study, Quantitative Structure Activity Relationship (QSAR) approaches were used to develop several computational models for ...
1M13: Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. Johns Wort
of the Gesellschaft Deutscher Chemiker 1994 International Edition in English 33/21 Pages 2121 -2228 COVER PICTURE The cover picture shows probably the most densely oxygenated complex fragment of ! The central triol-triacid "core" a natural product yet synthesized-C,,H,,O, (space-filling model at the top) of the fungal metabolite zaragozic acid A/squalestatin S1 (structural formula and space-filling model at the bottom) is depicted. Showing unprecedented promise as a medicinally useful inhibitor of squalene synthase (the enzyme controlling the first committed step in the biosynthesis of cholesterol), zaragozic acid A has attracted much attention in biological and chemical circles. The synthesis of the central core and the first total synthesis of zaragozic acid A/ squalestatin S1- -another race is over are described by K. C. Nicolaou et al. on p. 2184ff, 1187ff.. and 2190ff. (Red: oxygen. black: carbon, white: hydrogen; photograph: L. Gomez-Paloma, The Scripps Research Institute.) REVIEWS ...
One aspect of the present invention relates to diazabicyclo[4.3.0]nonanes. A second aspect of the present invention relates to the use of the diazabicyclo[4.3.0]nonanes as ligands for various cellular receptors, including opiate receptors. An additional aspect of the present invention relates to the use of the diazabicyclo[4.3.0]nonanes as analgesics.
We have built a new isonucleoside derivative on a 2,6-dioxobicyclo[3.2.0]heptane skeleton as a potential anti-HIV agent. To synthesize the target compound, an acetal-protected dihydroxyacetone was first converted to a 2,3-epoxy-tetrahydrofuran derivative. Introduction of an azide group, followed by the formation of an oxetane ring, gave a pseudosugar derivative with a 2,6-dioxobicyclo[3.2.0]heptane skeleton. The desired isonucleoside was obtained by constructing a purine base moiety on the scaffold, followed by amination.
ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES : : : Hetero ring is five-membered consisting of one nitrogen and four carbons (e.g., halopyrrolidines, etc.) : Polycyclo ring system having the five-membered hetero ring as one of the cyclos : Bicyclo ring system having the five-membered hetero ring as one of the cyclos (e.g., octahydroindoles, etc.) : Additional polycyclo heterocyclic ring system attached directly or indirectly to the bicyclo ring system by nonionic bonding : The additional polycyclo heterocyclic ring system has a lactone ring as one of the cyclos : Ring carbon of each of the two five-membered hetero rings is bonded directly to chalcogen or nitrogen (e.g., both rings may be bonded to the same nitrogen atom or to different nitrogen atoms, etc ...
The present invention relates to the use of a compound of the Formula (I) wherein: R1, R2, R3, R4, R5, R6, R7 and R8 denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R1, R2, R7 and R8 and at least one further of the radicals R1, R2, R3, R4, R5, R6, R7 a nd R8 are not hydrogen, wherein independently of one another also two of the radicals R1, R2, R3, R4, R5, R6, R7 a nd R8 can together denote a bridge with one or more bridge C atoms; Y1 and Y2 denote independently of one another hydrogen, methyl or ethyl; and Ra and Rb denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.
1-(4-methoxypyridin-3-ylmethyl)-4-((N-(7-(3-(S)-1-carbamoyl-1,1-diphenylmethyl)pyrrolidin-1-yl)hept-1-yl)-N-(isopropyl)amino) ...
The present invention relates to difluoroethyl-oxazole substituted bridged spiro[2.4] heptane derivatives of formula (I), ##STR00001## wherein the substituents at the piperidine ring are in trans-arr
Two phase transitions consecutively reduce the crystal symmetry with rising temperature in 1,4-diazabicyclo[2.2.2]octane hydrobromide, [C6H13N2]+·Br−, dabcoHBr. Low-temperature prototypic hexagonal phase III, space group P [[6 with combining macron]] m2, Z = 1 above 458 K transforms into orientational states of...
Citation: Macho, A., Blanco-Molina, M., Spagliardi, P., Appendino, G., Bremner, P., Heinrich, M., Fiebich, B. L. and Munoz, E. (2004) Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line. Biochemical Pharmacology, 68 (5), pp. 875-883. ...
Citation : Macho, A., Blanco-Molina, M., Spagliardi, P., Appendino, G., Bremner, P., Heinrich, M., Fiebich, B. L. and Munoz, E. (2004) Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line. Biochemical Pharmacology, 68 (5), pp. 875-883. ...
When your motorcycle calls for 89 octane and you run 87 what are the problems with that? During the winter I put fuel stabilizer in my gas and that kills the octane so in the spring when I run the engine for the first tank octane is probably at a very minimum. In a car the computer system adjusts itself to the octane level so you do not have the ping sound you had in an engine of the 1970s. Does the computer system in the bike adjust for the octane we have in the gas in our bike tanks?
SpiroChem AG is a Swiss fine chemical company in Basel, Switzerland. Tailor-made molecules, Oxetanes, Spirocycles, Cubanes, Bicyclo[1.1.1]pentanes, Pyridines
A series of novel 3′-(3-phenyl-3,4-dihydro-2H-pyrazol-5-yl)-2,2-dimethylspiro{bicyclo[2.2.1]heptan-3,5′-isoxazoline-2′}, 3′-(2,3-di phenyl-3,4-dihydropyrazol-5-yl)-2,2-dimethylspiro{bi cyclo[2.2.1] heptan-3,5′-isoxazoline-2′} and 5-Octyl-3-(3-phenyl-3,4-dihydro-2H-pyrazol-5-yl)isoxazoline-2,5-decyl-3-(2,3-diphenyl--3,4-dihy dro pyrazol-5-yl)isoxazoline-2 have been prepared and screened for their antibacterial and antifungal activity ...
SpiroChem AG is a Swiss fine chemical company in Basel, Switzerland. Tailor-made molecules, Oxetanes, Spirocycles, Cubanes, Bicyclo[1.1.1]pentanes, SF5
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Reactive intermediates in the tetracyclo-[3.3.0.0² ⁷.0⁴ ⁶] octane, the tetracyclo-[3.3.0.0² ⁴.0³ ⁷] octane, and related ring systems containing the norbornane skeleton Public Deposited ...
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News Analysis Scientists Continue to Use Outdated Methods The use of underperforming computational tools is a major offender in sciences reproducibility crisis-and theres growing momentum to avoid it.. ...
Pestunovich V.A.; Sidorkin V.F.; Shagun V.A.; Voronkov M.G.; Giller S.A.; Liepinsh E.E.; Eremeev A.V. Conformational analysis of 2-phenyl-1,3-diazabicyclo[3.1.0]hexane. Chem. Heterocycl. Compd. 1975, 11(7), 821-823 ...
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St Johns wort is being studied for effectiveness in the treatment of certain somatoform disorders. Results from the initial studies are mixed and still inconclusive; some research has found no effectiveness, other research has found a slight lightening of symptoms. Further study is needed and is being performed.. A major constituent chemical, hyperforin, may be useful for treatment of alcoholism, although dosage, safety and efficacy have not been studied.[110][111] Hyperforin has also displayed antibacterial properties against Gram-positive bacteria, although dosage, safety and efficacy has not been studied.[112] Herbal medicine has also employed lipophilic extracts from St Johns wort as a topical remedy for wounds, abrasions, burns, and muscle pain.[111] The positive effects that have been observed are generally attributed to hyperforin due to its possible antibacterial and anti-inflammatory effects.[111] For this reason hyperforin may be useful in the treatment of infected wounds and ...
Hypericum perforatum extract is prepared from a flowering plant species of the genus Hypericum. Hypericum perforatum extract, also known as St Johns wort extract, is a s
St. Johns wort (Hypericum perforatum) is a flowering shrub native to Europe. It gets its name from the fact that it often blooms on the birthday of the biblical John the Baptist.. The flowers and leaves of St. Johns wort contain active ingredients such as hyperforin. St. Johns wort is available as a supplement in teas, tablets, liquids and topical preparations.. St. Johns wort is often used to treat depression and menopausal symptoms.. Research on St. Johns wort use for specific conditions shows:. ...
RATIONALE: Antidepressants such as sertraline and the herb hypericum perforatum (St. Johns wort) may be effective in treating mild to moderate depressi
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see article for more reactions. Abstract. An efficient and simple method enables the N-alkylation of aromatic cyclic imides using cesium carbonate as the base in anhydrous N,N-dimethylformamide at low temperatures (20-70˚C). The employment of microwave irradiation presents noteworthy advantages over conventional heating. The method is compatible with base labile functional groups.. ...
ACKGROUND: The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. Johns wort) extract WS 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses. METHODS: The participants in this double-blind, randomized, placebo-controlled, multi-center clinical trial were male and female adult out-patients with an episode of mild or moderate major depressive episode (single or recurrent episode, DSM-IV criteria). As specified by the relevant guideline, the study was preceded by a medication-free run-in phase. For the 6-week treatment, 332 patients were randomized: 123 to WS 5570 600 mg/day, 127 to WS 5570 1200 mg/day, and 82 to placebo. The primary outcome measure was the change in total score on the Hamilton Rating Scale for Depression (HAM-D, 17-item version) between baseline and endpoint. Additional measures included the number of responders, the number of patients in remission, and several other standard rating scales. Efficacy and ...
Meridian Botanicals St. Johns wort complex teapills - Certified organic whole cut of St. Johns wort powder, reinforced with a full spectrum hydro-alcoholic extract that has been concentrated to a 3% hyperforin and 0.3% hypercin content. 400-450 mg herbs per capsule, 50 vegetarian capsules sealed in a brown amber glass jar. Also known as Hypericum perforatum Introduction Originally native to
InjuryBoard News: St. Johns Wort - Find trial lawyers and attorneys with experience in lawsuits involving St. Johns Wort. Contact an attorney who can help you protect your legal rights, fre
Hypericum Perforatum Perforate St Johns-wort photo, resolution 1875×2500 pixel, Image type JPEG, free download and free for commercial use.
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The effect of blocking groups and stereochemistry of the substituents on the regio- and stereoselectivity in intramolecular nitrone-alkene cycloaddition (INAC) of hept-6-enoses are reported. L-ribo-Hept-6-enose 12 and D-lyxo-hept-6-enose 15, both containing a 2,3-O-isopropylidene blocking group, and L-xylo-hept-6-enose 23 and D-arabino-hept-6-enose 30, both with a 2,3-O-trans-diacetal blocking group, were prepared from D-ribose and D-arabinose, respectively. With N-alkyl hydroxylamine, lactols 12 and 15 underwent an INAC reaction to give cis-fused isoxazolidines exclusively whereas lactols 23 and 30 gave a mixture of cis-, trans-fused isoxazolidines (cyclohexanols) and bridged isoxazolidines (cycloheptanols). With the 2,3-O-trans-diacetal protecting group, the bridged bicyclo[4.2.1]isoxazolidines (cycloheptanols), via the endo mode of INAC cyclization, were synthesized for the first time from unbranched sugar derivatives 23 and 30. The stereochemical outcomes of these reactions were rationalized on the
Also type of: Hypericum officinale Gaterau., Hypericum officinarum Cr., Hypericum perforatum var. normale Woron., Hypericum vulgare Lam., Hypericum perforatum var. [alpha] typicum Beck. ...
Commercially available St. Johns wort supplement (SJWS) composed of an herbal mixture of St. Johns Wort (SJW), Rosemary (RM) and Spirulina (SP) is used as a dietary supplement for the treatment of psychiatric disorders. Although the minor ingredients, (RM and SP) are proven antioxidants, their quantity is quite insignificant as compared to the SJW, which is the major ingredient. Most of the toxic effects of SJWS are attributed to the main constituents of SJW which differ due to the influence of light (hypericin) and variations in temperature above freezing point (hyperforin). However, there are no reports on toxicity of SJWS maintained at room temperature in pharmacies and supermarkets. In view of the folkloric importance, immense (prescribed or unprescribed) use and a paucity of literature on SJWS, it was found worthwhile to (1) determine the genotoxic effects of SJWS in somatic and germ cells of mice and (2) investigate the role of biochemical changes, as a possible mechanism. The protocol included
While some studies and research reviews have supported the efficacy of St Johns wort as a treatment for depression in humans, in the United States, it is not recommended as a replacement for more studied treatments, and it is advised that symptoms of depression warrant proper medical consultation.[20] A 2015 meta-analysis review concluded that it has superior efficacy to placebo in treating depression, is as effective as standard antidepressant pharmaceuticals for treating depression, and has fewer adverse effects than other antidepressants.[47] The authors concluded that it is difficult to assign a place for St. Johns wort in the treatment of depression owing to limitations in the available evidence base, including large variations in efficacy seen in trials performed in German-speaking relative to other countries. In Germany, St. Johns wort may be prescribed for mild to moderate depression, especially in children and adolescents.[48] A 2008 Cochrane review of 29 clinical trials concluded ...
St. Johns Wort is a popular kind of plant used for its properties since the Middle Ages. It contains Hyperforin, Hypericin and flavonoids.This product is Kosher certified.. ...
Pinene (C10H16) is a bicyclic monoterpene chemical compound.[1] There are two structural isomers of pinene found in nature: α-pinene and β-pinene. As the name suggests, both forms are important constituents of pine resin; they are also found in the resins of many other conifers, as well as in non-coniferous plants such as camphorweed (Heterotheca) and big sagebrush (Artemisia tridentata). Both isomers are used by many insects in their chemical communication system. The two isomers of pinene constitute the major component of turpentine. α-Pinene and β-pinene are both produced from geranyl pyrophosphate, via cyclisation of linaloyl pyrophosphate followed by loss of a proton from the carbocation equivalent. Researchers at the Georgia Institute of Technology and the Joint BioEnergy Institute have been able to synthetically produce pinene with a bacterium. Alpha-pinene is the most widely encountered terpenoid in nature and is highly repellant to insects. Alpha-pinene appears in conifers and ...
1. Depression Treatment- One of the scientifically proven St Johns Wort benefits is that this herb increases serotonin levels in the brain. This effect is the reason that the herb is commonly used to treat depression. 2. Anxiety Treatment- With the proper St Johns Wort dosage the herb can be effective for treating anxiety and related conditions. The effect that St. Johns Wort has on many of the neurotransmitters in the brain makes it a good choice for this disorder. 3. Smoking Cessation Support- St Johns Wort can help lessen the withdrawal symptoms and cravings that you experience when you stop smoking cigarettes. 4. PMS Treatment- Treating PMS is one of the top St Johns Wort benefits for many women. The use of this herb can minimize or even eliminate the symptoms of PMS and provide relief. 5. Obsessive Compulsive Treatment- St Johns Wort depression treatment is well known. What is less known is that this herb can also help treat obsessive compulsive disorder and certain other mental ...
Herbal medicine. herb data for St. Johns Wort, Hypericum Perforatum, Johnswort, Amber, Touch-and-heal, Goat weed, Hardhay, Klamath Weed, Rosin Rose, Hypericum, Tipton weed
TY - JOUR. T1 - Vagal afferent fibres determine the oxytocin-induced modulation of gastric tone. AU - Holmes, Gregory M.. AU - Browning, Kirsteen N.. AU - Babic, Tanja. AU - Fortna, Samuel R.. AU - Coleman, F. Holly. AU - Travagli, R. Alberto. PY - 2013/6/1. Y1 - 2013/6/1. N2 - Oxytocin (OXT) inputs to the dorsal vagal complex (DVC; nucleus of the tractus solitarius (NTS) dorsal motor nucleus of the vagus (DMV) and area postrema) decrease gastric tone and motility. Our first aim was to investigate the mechanism(s) of OXT-induced gastric relaxation. We demonstrated recently that vagal afferent inputs modulate NTS-DMV synapses involved in gastric and pancreatic reflexes via group II metabotropic glutamate receptors (mGluRs). Our second aim was to investigate whether group II mGluRs similarly influence the response of vagal motoneurons to OXT. Microinjection of OXT in the DVC decreased gastric tone in a dose-dependent manner. The OXT-induced gastric relaxation was enhanced following bethanechol and ...
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to neurological pathologies such as epilepsy, but the precise mechanisms by which this feedback can occur remain incompletely understood. At one glutamatergic synapse, the Drosophila neuromuscular junction, a mutation in the group II metabotropic glutamate receptor gene ( DmGluRA ) increased motor neuron excitability by disrupting an autocrine, glutamate-mediated negative feedback. I show that DmGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo. Furthermore, glutamate application increases levels of phospho-Akt, a product of PI3K signaling, within motor nerve terminals in a DmGluRA -dependent manner. Finally, I show that PI3K increases both axon diameter and synapse number via the ...

Stereospecific synthesis | Article about stereospecific synthesis by The Free DictionaryStereospecific synthesis | Article about stereospecific synthesis by The Free Dictionary

Oxidation of substituted bicyclo[4.4.0]decen-3-ones/Asendatud bitsuklo[4.4.0]detsen-3-oonide oksudeerimine ... and coordination complexes in metal mediated stereospecific synthesis of asymmetric carbon and main group element compounds.. ...
more infohttps://encyclopedia2.thefreedictionary.com/stereospecific+synthesis

Asymmetric Conjugate Addition | Sigma-AldrichAsymmetric Conjugate Addition | Sigma-Aldrich

investigated the asymmetric 1,4-addition of aryl boronic acids to α,β-unsaturated carbonyl compounds.5 Using 2.5 mol% of [RhCl( ... developed a new type of diene ligand based on a nonbridged bicyclo[3.3.0]octadiene framework.4 The two cis-fused ... Carreira and co-workers reported the asymmetric synthesis of 3,3-diarylpropanals using a chiral bicyclo[2.2.2]octadiene as a ...
more infohttps://www.sigmaaldrich.com/technical-documents/articles/chemfiles/asymmetric-conjugate.html

Clinical trials in irritable bowel syndro... & related info | MendeleyClinical trials in irritable bowel syndro... & related info | Mendeley

Bicyclo Compounds. *Biphenyl Compounds. *Biphenyl Compounds: therapeutic use. *Carbolines. *Carbolines: therapeutic use ...
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Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.

Bicyclo Compounds / pharmacology. Cyclooxygenase 1 / metabolism. Cyclooxygenase 2 / drug effects, metabolism. Cyclooxygenase 2 ... 0/Bicyclo Compounds; 0/Cyclooxygenase 2 Inhibitors; 0/Hexanoic Acids; 0/Lactones; 0/Membrane Proteins; 0/ONO 8711; 0/Ptgir ...
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PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.

PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ... Aza Compounds / pharmacology*. Bicyclo Compounds, Heterocyclic / pharmacology*. Breast Neoplasms / metabolism*. Cell Line, ... 0/2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one; 0/Antineoplastic Agents; 0/Aza Compounds; 0/Bicyclo Compounds, ... PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ...
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MEDLINE - Resultado p gina 1
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Bridged Bicyclo Compounds, Heterocyclic); 0 (Calcitonin Receptor-Like Protein); 0 (Calcrl protein, rat); 0 (Dipeptides); 0 ( ... Spiro Compounds); 0 (Vasodilator Agents); 83652-28-2 (Calcitonin Gene-Related Peptide); D42O649ALL (telcagepant); WOA5J8TX6M ( ...
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Patent US6632318 - Method for solvent bonding polyolefins - Google PatentsPatent US6632318 - Method for solvent bonding polyolefins - Google Patents

Random copolymer containing derivative of bicyclo [2.2.1] hept-2-ene compound. ... comprising titanium compounds and organoaluminum compounds or vanadium-containing catalysts comprising vanadium compounds and ... Ethylene/bicyclo(2.2.1)hept-2-ene copolymers. US4573994. Dec 7, 1981. Mar 4, 1986. The Johns Hopkins University. Refillable ... 0 556 034 discloses a medical instrument of a material containing a resin of a cyclic olefin compound or a bridged polycyclic ...
more infohttp://www.google.com/patents/US6632318?dq=6,049,612

NASA Technical Reports Server (NTRS) - The evolution of glutathione metabolism in phototrophic microorganismsNASA Technical Reports Server (NTRS) - The evolution of glutathione metabolism in phototrophic microorganisms

BICYCLO COMPOUNDS/METABOLISM BLUE GREEN ALGAE CHLOROBI CHROMATIUM CYANOBACTERIA DISULFIDES DISULFIDES/ANALYSIS EUKARYOTES ... BICYCLO COMPOUNDS/METABOLISM; CHLOROBI; CHROMATIUM; CYANOBACTERIA; DISULFIDES/ANALYSIS; EUKARYOTIC CELLS; OXIDATION-REDUCTION; ... BACTERIA/CHEMISTRY/METABOLISM; EVOLUTION; GLUTATHIONE/METABOLISM; SULFHYDRYL COMPOUNDS/ANALYSIS; ALGAE, GREEN; BACTERIAL ...
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Search ResultsSearch Results

The standard enthalpies of formation of bicyclo compounds. 2. Bicyclo[3.3.1]nonane and bicyclo[3.3.2]decane, J. Chem. Thermodyn ... The Standard Enthalpies of FOrmation of Bicyclo Compounds 2. Bicyclo[3.3.1] nonane and Bicyclo[3.3.2]decane, J, Chem. Thermodyn ... Steele, W.V., The standard enthalpies of formation of bicyclic compounds. IV. Bicyclo[2.2.1]heptan-2-one and bicyclo[2.2.1] ... Steele, W.V., The Standard Enthalpies of Formation of Bicylclic Compounds IV. Bicyclo[2,2,1]heptan-2-one and Bicyclo[2.2.1] ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?Author=Steele%2C+W.V.&Units=CAL&Mask=1A8F

Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)

Categories: Bicyclo Compounds, Heterocyclic Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
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Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)

Categories: Bicyclo Compounds, Heterocyclic Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
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Patent US5786441 - Polymers, elastomeric compounds and products thereof, derived from novel ... - Google PatentsPatent US5786441 - Polymers, elastomeric compounds and products thereof, derived from novel ... - Google Patents

... can include multi-cyclo compounds such as bicyclo and tricyclo compounds. It should be understood that two bridging bonds will ... For example, the bicyclo compounds that are generally defined by formula (I) can more specifically be represented by formulas ( ... As an example, two R2 bridging bonds can form a bridge across the cyclic amino ring, and thereby create a bicyclo compound. ... Accordingly, it should also be understood that the Z containing moiety can be tethered to the bicyclo compound in the one ring ...
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Ibrutinib Plus Venetoclax for the Treatment of Mantle-Cell Lymphoma - PubMedIbrutinib Plus Venetoclax for the Treatment of Mantle-Cell Lymphoma - PubMed

Bridged Bicyclo Compounds, Heterocyclic / administration & dosage *. Actions. * Search in PubMed * Search in MeSH ...
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US7890103B2 - Wireless base station and mobile station 
        - Google PatentsUS7890103B2 - Wireless base station and mobile station - Google Patents

Compounds having [2.2.1] bicyclo skeleton US6330446B1 (en) * 1998-04-08. 2001-12-11. Oki Electric Industry Co., Ltd.. Velocity- ... Compounds having [2.2.1] bicyclo skeleton US6272344B1 (en) 1998-06-09. 2001-08-07. Nec Corporation. Position registration ...
more infohttps://patents.google.com/patent/US7890103B2/en

Polyquinane - WikipediaPolyquinane - Wikipedia

The simplest member is the bicyclic compound bicyclo[3.3.0]octane. Other members are triquinacene and dodecahedrane. The ... and also as part of a failed attempt to synthesize the then-elusive and much-coveted compound dodecahedrane. Unlike the related ... compound triquinacene (tricyclo[5.2.1.-04,10]deca-2,5,8-triene) is the second member of a family of polyquinenes. It was ...
more infohttps://en.wikipedia.org/wiki/Polyquinane

DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS - MERCK SHARP &...DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS - MERCK SHARP &...

Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating ... which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. ... Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, ... tetrahydrothiophenyl, tetrahydrothiopyranyl, and the like; and polycyclicheterocyclyl compounds, for example, a bicyclo moiety ...
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Bicyclic molecule - WikipediaBicyclic molecule - Wikipedia

Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. In between the ... Therefore, fused bicyclic compounds have a "0" included in the brackets. For example, decalin is named bicyclo[4.4.0]decane. ... An example of a spirocyclic compound is the photochromic switch spiropyran. In fused bicyclic compounds, two rings share two ... When naming simple fused bicyclic compounds, the same method as for bridged bicyclic compounds is applied, except the third ...
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NEET Yearlong Organic Chemistry for Class 11th by NJ SirNEET Yearlong Organic Chemistry for Class 11th by NJ Sir

6 Nomenclature of Unsaturated Compound (Alkenes/Alkynes), Bicyclo compounds 64 Min. 7 Nomenclature of Spiro Compounds, ... 9 Multiple Functional Group Compounds, Aromatic Compounds Nomenclature, Common Names 55 Min. ... 1Classification and Nomenclature of Organic Compound 1 Bonding and Hybridisation of Carbon 55 Min. ... 3 Identification of Functional Groups, Homocyclic and Heterocyclic Compound, Homologous Series 47 Min. ...
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Dimethyl fumarate - WikipediaDimethyl fumarate - Wikipedia

With this reaction, compounds with bicyclo skeletons can be synthesized, e.g. a diester with a norbornene (bicyclo[2.2.1] ... The compound (and its metabolite, monomethyl fumarate) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway ... As a α,β-unsaturated electrophilic compound, dimethyl fumarate is rapidly attacked by the detoxifying agent glutathione (GSH) ... Boyland, E; Chasseaud, LF (1967). "Enzyme-catalysed conjugations of glutathione with unsaturated compounds". The Biochemical ...
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Simple Accordion with CSS & jQuery by Soh TanakaSimple Accordion with CSS & jQuery by Soh Tanaka

C. Bicyclo[3.3.0]octane-2,6-dione. (Compound 4; (Note 10).) Diol 3, 12.6 g (0.089 mol), is placed in a 250-ml, three-necked, ... B. Bicyclo[3.3.0]octane-2,6-diol. (Compound 3; (Note 5).) An ice-cooled aqueous 10% solution of sodium hydroxide (100 mL) is ... A. 2,6-Diacetoxybicyclo[3.3.0]octane. (Compound 2; (Note 1) and (Note 2).) An ovendried. 1-L round-bottomed flask, equipped ... Bicyclo[3.3.0]octane-2,6-dione has been known since 1934,10 but extant procedures for large-scale multigram synthesis of this ...
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Compound RecordCompound Record

Spiro{bicyclo[4.2.0]octa-1,3,5-triene-7,2′-[1,3]-dioxolan}-8-one. Encyclopedia of Reagents for Organic Synthesis. Gary W. ...
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Class Schedule for Class 560 ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIESClass Schedule for Class 560 ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES

4 indent ) 2,2,1-bicyclo 121 .. (2 indent ) Cyclopentyl in acid moiety (e.g., prostaglandins, etc.) ... 4 indent ) Epoxy compound, or metal, utilized 354 .. (2 indent ) Containing polycyclo ring system having alicyclic ring as one ... 1 indent ) Compounds having the group -C(=X)-X-nX-, wherein the Xs may be the same or diverse chalcogens, nX is a divalent ... 1 indent ) Peroxynitrate esters (i.e., compounds having the -O-O-N(=O)(=O) group bonded directly to carbon, which carbon may be ...
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Dissertations.se: INDIUM COMPOUNDSDissertations.se: INDIUM COMPOUNDS

... about INDIUM COMPOUNDS. Search and download thousands of Swedish university dissertations. Full text. Free. ... 3. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics. University dissertation ... Search for dissertations about: indium compounds. Showing result 1 - 5 of 9 swedish dissertations containing the words indium ... Abstract : Volatile organic compounds (VOCs) in the indoor air have adverse effects on the dwellers residing in a building or a ...
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Bicyclo[3.1.0]hexan-2-one | C6H8O - PubChemBicyclo[3.1.0]hexan-2-one | C6H8O - PubChem

Bicyclo[3.1.0]hexan-2-one , C6H8O , CID 549294 - structure, chemical names, physical and chemical properties, classification, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/Bicyclo_3.1.0_hexan-2-one
  • Other groups focus on applications of chiral transition-metal organometallics and coordination complexes in metal mediated stereospecific synthesis of asymmetric carbon and main group element compounds. (thefreedictionary.com)
  • The present invention provides applications of a small molecular flavonoid compound in preparing a medication for sensitizing/synergizing tumor radiation. (patents.com)
  • The oil is then distilled under reduced pressure (74-79°C at 0.06 mm) to yield analytically pure bicyclo[3.3.u>octane-2,6-dione , 4 ( 6.4-7.1 g , 52-58% ) as a white crystalline solid, mp 45-46°C (lit. (orgsyn.org)
  • Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. (sumobrain.com)
  • said compound is unsubstituted or substituted with a halo, alkyl, alkoxy, or combinations thereof. (google.com.au)
  • The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. (patents.com)
  • A compound of formula (I). The present invention relates to therapeutically active .beta. (patents.com)
  • Overall, the invention provides the chemistry for the compounds and for the processes to prepare compounds derived from 1,5-diazacyclooctanes. (patents.com)
  • In the present invention, the substrates followed by the prefix "perfluoro" mean substrates having all of the hydrogens replaced by fluorine atoms but containing no halogens such as chlorine, bromine and iodine, and they may be cyclic or straight-chain compounds. (freepatentsonline.com)
  • In particular, this invention pertains to the method of improving sensitivity in laser induced thermal imaging using diazo compounds. (patent-de.com)
  • In accordance with the present invention, the sensitivity of laser induced thermal imaging systems can be increased by using diazo compounds that contain at least one electron withdrawing functional group adjacent the diazo substituent capable of stabilizing the diazo substituent (i.e., the =N + =N - substituent). (patent-de.com)
  • C 1 -C 6 alkyl, Y and M are the same as for compounds of formula (I). The invention also relates to a pharmaceutical composition based on compounds (I) and (II), having inhibiting action on histone deacetylase (HDAC), a method of inhibiting and a method of treating a disease which is sensitive to the HDAC inhibitor. (russianpatents.com)
  • Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same. (sumobrain.com)
  • We do not sell or distribute the pharmaceutical compounds written about in this database. (springer.com)
  • Comprising 20% of pharmaceutical products and 30% of agrochemical compounds, as well as playing a key role in electric cars, electronic devices, and space technology, compounds containing fluorine have grown in importance across the globe. (wiley.com)
  • There are prepared reaction products of a. 4,4-bis-(hydroxymethyl)-cyclohexene compounds of the formula ##EQU1## where R1, R2 and R4 are the same or different and are hydrogen, methyl or phenyl and there is also present either (1) X as the bridging member methylene or ethylene or (2) X is absent and. (google.ca)
  • EFFECT: compounds of formula I and II as histone deacetylase inhibitors. (russianpatents.com)
  • The numbers are sometimes omitted when no ambiguity is created as there is no alternative possible - for example, bicyclo[1.1.utane is typically called simply bicyclobutane. (wikipedia.org)
  • In fused bicyclic compounds, two rings share two adjacent atoms. (wikipedia.org)
  • In bridged bicyclic compounds, the two rings share three or more atoms, separating the two bridgehead atoms by a bridge containing at least one atom. (wikipedia.org)
  • For example, norbornane, also known as bicyclo[2.2.eptane, can be thought of as a pair of cyclopentane rings each sharing three of their five carbon atoms. (wikipedia.org)
  • The root of the compound name depends on the total number of atoms in all rings together, possibly followed by a suffix denoting the functional group with the highest priority. (wikipedia.org)
  • When naming simple fused bicyclic compounds, the same method as for bridged bicyclic compounds is applied, except the third path between the two bridgehead atoms now consists of zero atoms. (wikipedia.org)
  • The only exception to this requirement is that the compounds may contain metal atoms, but only as the cations of heterocyclic organic acid salts, alcoholates, phenolates or mercaptides, or as chelating atoms, e.g. in porphyrins. (uspto.gov)
  • Cover compounds containing one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system, with or without other non-condensed hetero rings. (uspto.gov)
  • With this reaction, compounds with bicyclo skeletons can be synthesized, e.g. a diester with a norbornene (bicyclo[2.2.eptene) skeleton from dimethyl fumarate and cyclopentadiene. (wikipedia.org)
  • As a α,β-unsaturated electrophilic compound, dimethyl fumarate is rapidly attacked by the detoxifying agent glutathione (GSH) in a Michael addition reaction. (wikipedia.org)
  • A phase transfer catalyst facilitates the reaction in a heterogeneous system between general organic compounds that are soluble in organic solvents and com. (reference.com)
  • Bringing together the research and methods of leading scientists in the fluorine field, Efficient Preparations of Fluorine Compounds is the definitive manual to creating, and understanding the reaction mechanisms integral to a wide variety of fluorine compounds. (wiley.com)
  • The low-molecular weight organic compounds (LMWOC) of the extracts were defined by methods of GC/MS with the help of Shimadzu GC/MS (QP-5050А, Shimadzu, Japan) equipped with the software Class 5000 and chromato-mass spectrometer TRACE DSQ II (Thermo Electron Corporation) with quadrupole mass analyser. (ijpsonline.com)
  • Preparations for medical, dental, or toilet purposes or methods of using compounds for the same purposes are classified in subclass A61K . (uspto.gov)
  • Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds. (docme.ru)
  • DOI: 10.1002/anie.200900013 Palladium Catalysis Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds Anne Brennfhrer, Helfried Neumann, and Matthias Beller* Keywords: aryl halides · carbon monoxide · carbonylation · homogeneous catalysis · palladium Dedicated to Professor Armin de Meijere on the occasion of his 70th birthday Angewandte Chemie 4114 www.angewandte.org 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew. (docme.ru)
  • This Review summarizes the recent work in the area of palladium-catalyzed carbonylation reactions of aryl halides and related compounds. (docme.ru)
  • The position and number of substituents in benzyl group attached to N− 8 of diazaspiro bicyclo hydantoin nucleus interacted selectively with specific targets leading to the difference of biochemical and pharmacological effects. (springer.com)
  • It has been observed that these compounds displayed strong, moderate and weak cytotoxic activities. (springer.com)
  • Interestingly, compounds having electron withdrawing groups at third and fourth position of the phenyl ring displayed selectively cytotoxic activities to both the cell lines tested with IC 50 value lower than 50 μM. (springer.com)
  • Heterocycles incorporating elements other than C, H, halogen, N, O, S, Se or Te are classified in subclass C07F , but only if the metal-containing compound has a metal carbon bond or if the metal is attached to at least two different ligands. (uspto.gov)
  • Specifically, infrared light which has been generated by a laser is first absorbed by a radiation absorber (e.g., an infrared absorbing material such as an infrared dye, black alumina, or carbon black) and then converted to heat to decompose the energetic compound. (patent-de.com)
  • Preparation of such compounds, including purification, separation, stabilisation or use of additives, unless a separate place is provided elsewhere in the classification scheme. (uspto.gov)
  • Salts, chelates, alcoholates (except Ti/Zr), phenates involving a single ligand are classified as the parent compound (metal containing porphyrin C07D 487/22 ). (uspto.gov)
  • Examples of such energetic compounds include diazonium salts as well as compounds containing azo, azido, nitrato, and nitramino groups, such as nitrocellulose, polyvinyl nitrates, and the like. (patent-de.com)
  • In class C07 , the last place priority rule is used, i.e. in the absence of an indication to the contrary, a compound is classified in the last appropriate subclass. (uspto.gov)
  • Similarly, compounds containing saccharide radicals are classified in subclass C07H , and heterocyclic steroids are classified in subclass C07J . (uspto.gov)
  • This subclass is a structure-oriented entry for the compounds themselves and does not cover the application or use of the compounds under the subclass definition. (uspto.gov)
  • Biocidal, pest attractant, or plant growth regulatory activity of chemical compounds or preparations is further classified in subclass A01P (this subclass does only exist in IPC).Therapeutic activity of chemical compounds is further classified in subclass A61P . (uspto.gov)
  • Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. (google.com.au)
  • Preferably, at least two such functional groups are present in the compound. (patent-de.com)
  • Gas chromatographic-mass spectrometric method for the identification and determination of organotin compounds in aqueous solutions has been employed. (vu.lt)
  • The composition of detectable small organic compounds in the ethanol extract of Achillea micrantha was defined by means of gas chromatography-mass spectrometric analysis. (ijpsonline.com)