A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)
Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Drugs that selectively bind to and activate ADENOSINE A3 RECEPTORS.
Compounds that selectively bind to and block the activation of ADENOSINE A3 RECEPTORS.
Attachment of isoprenoids (TERPENES) to other compounds, especially PROTEINS and FLAVONOIDS.
An industrial solvent which causes nervous system degeneration. MBK is an acronym often used to refer to it.
Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)
A group of compounds with an 8-carbon ring. They may be saturated or unsaturated.
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The characteristic three-dimensional shape of a molecule.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)
Exclusive legal rights or privileges applied to inventions, plants, etc.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Microdevices that combine microfluidics technology with electrical and/or mechanical functions for analyzing very small fluid volumes. They consist of microchannels etched into substrates made of silicon, glass, or polymer using processes similar to photolithography. The test fluids in the channels can then interact with different elements such as electrodes, photodetectors, chemical sensors, pumps, and valves.
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
Processes by which phototrophic organisms use sunlight as their primary energy source. Contrasts with chemotrophic processes which do not depend on light and function in deriving energy from exogenous chemical sources. Photoautotrophy (or photolithotrophy) is the ability to use sunlight as energy to fix inorganic nutrients to be used for other organic requirements. Photoautotrophs include all GREEN PLANTS; GREEN ALGAE; CYANOBACTERIA; and green and PURPLE SULFUR BACTERIA. Photoheterotrophs or photoorganotrophs require a supply of organic nutrients for their organic requirements but use sunlight as their primary energy source; examples include certain PURPLE NONSULFUR BACTERIA. Depending on environmental conditions some organisms can switch between different nutritional modes (AUTOTROPHY; HETEROTROPHY; chemotrophy; or phototrophy) to utilize different sources to meet their nutrients and energy requirements.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)
Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Activities performed in the preparation of bibliographic records for CATALOGS. It is carried out according to a set of rules and contains information enabling the user to know what is available and where items can be found.
Isomeric forms and derivatives of hexanol (C6H11OH).
6-carbon straight-chain or branched ketones.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
A technique of operations research for solving certain kinds of problems involving many variables where a best value or set of best values is to be found. It is most likely to be feasible when the quantity to be optimized, sometimes called the objective function, can be stated as a mathematical expression in terms of the various activities within the system, and when this expression is simply proportional to the measure of the activities, i.e., is linear, and when all the restrictions are also linear. It is different from computer programming, although problems using linear programming techniques may be programmed on a computer.
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.

Drug-protein binding and blood-brain barrier permeability. (1/549)

The permeability surface area (PS) product, an index of permeability of the blood-brain barrier (BBB), was measured by using the in situ perfusion method. In the cerebral circulation, the fraction of drug that permeates into the brain through the BBB is not only the unbound fraction but also the fraction dissociated from the protein in the perfusate. The sum of these two fractions, the apparent exchangeable fraction, was estimated by fitting the parameters of the BBB permeability under the condition of varying BSA concentrations in the perfusate. The unbound fraction of drugs in a buffer containing 0.5 mM BSA was measured by using the ultrafiltration method in vitro, and the apparent exchangeable fraction was measured in vivo by using the intracarotid artery injection method. The apparent exchange fraction was 100% for S-8510, 96.5% for diazepam, 90.9% for caffeine, 38.3% for S-312-d, 33.1% for propranolol, and 6.68% for (+)-S-145 Na, and each of these was higher than the corresponding unbound fraction in vitro in all drugs. The apparent exchangeable fractions, for example, were 8 times higher for diazepam and 38 times for S-312-d than the unbound fractions in vitro. The apparent exchangeable fraction of drugs was also estimated from the parameters obtained with the perfusion method. Because drugs can be infused for an arbitrary length of time in the perfusion method, substances with low permeability can be measured. The apparent exchangeable fractions obtained with this method were almost the same as those obtained with the intracarotid artery injection method.  (+info)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (2/549)

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.  (+info)

Isolation and structural determination of a novel bicyclic taxane diterpene from needles of the Chinese yew, Taxus mairei. (3/549)

A novel bicyclic taxane diterpene with a rare 12-membered ring was isolated from needles of the Chinese yew, Taxus mairei, and its structure was established as (3E, 8E)-2 alpha, 7 beta, 9, 10 beta, 13 alpha, 20-hexaacetoxy-5(2'-acetoxy-cinnamoyloxy)-3,8-secotaxa -3,8,11-triene (1) with the help of 1D and 2D NMR data. The relative stereochemistry was deduced from a NOESY experiment.  (+info)

Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury. (4/549)

We examined the effects of modulating group II metabotropic glutamate receptors (mGluRs) on traumatic neuronal injury using both in vitro and in vivo models. Treatment with various selective group II mGluR agonists significantly decreased lactate dehydrogenase release, a marker of cell death, after traumatic injury to rat neuronal-glial cultures; injury-induced increases in cyclic AMP and glutamate levels were also significantly reduced by a group II agonist. The neuroprotective effects of group II agonists were markedly attenuated by coadministration of a group II antagonist or a membrane-permeable cyclic AMP analog and were additive to those provided by an N-methyl-D-aspartate receptor antagonist or a selective group I mGluR antagonist. Administration of a group II mGluR agonist 30 min after lateral fluid percussion-induced brain injury in rats significantly improved subsequent behavioral recovery as compared with vehicle-treated controls. Together these studies indicate that group II mGluR agonists protect against traumatic neuronal injury by attenuating glutamate release and cAMP levels and suggest a potential role for these agents in the treatment of clinical neurotrauma.  (+info)

Endothelium-derived contracting factor in carotid artery of hypertensive Dahl rats. (5/549)

The present study is designed to investigate whether acetylcholine (ACh) elicits an endothelium-derived contracting factor (EDCF) and whether it contributes to decreased relaxant response induced by ACh in Dahl rats. Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a 0.4% NaCl or an 8% NaCl diet for 4 weeks. High sodium intake significantly increased blood pressure in DS rats but not in DR rats. The carotid rings were suspended for isometric tension recording. ACh caused an endothelium-dependent contraction in carotid rings from hypertensive DS rats but not from normotensive Dahl rats. Atropine, indomethacin, SQ29548, or ONO-3708 (prostaglandin H(2) [PGH(2)]/thromboxane A(2) [TXA(2)] receptor antagonist) abolished ACh-induced contraction, and OKY-046 (inhibitor of TXA(2) synthetase) partially attenuated the contraction. High sodium intake significantly enhanced contraction evoked by U46619, a PGH(2)/TXA(2) receptor agonist, in both DS and DR rats. In contrast, ACh-induced relaxation was significantly depressed in the rings from hypertensive DS rats, and ONO-3708 partially improved the depressed relaxation. Administration of ONO-8809 (an orally active PGH(2)/TXA(2) receptor antagonist; 30 micrograms per body per day) for 4 weeks neither reduced blood pressure nor improved the depressed ACh-induced relaxation in hypertensive DS rats. These results suggest that ACh causes release of EDCF in carotid rings of hypertensive DS rats, which is likely to be PGH(2) and TXA(2). The EDCF contributed in part to the depressed ACh-induced relaxation.  (+info)

Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes. (6/549)

Type II pneumocytes, which synthesize, store, and secrete pulmonary surfactant, require exogenous fatty acids, in particular palmitic acid, for maximum surfactant synthesis. The uptake of palmitate by type II pneumocytes is thought to be protein mediated, but the protein involved has not been characterized. Here we show by RT-PCR and Northern blot analysis that rat type II pneumocytes express the mRNA for fatty acid translocase (FAT/CD36), a membrane-associated protein that is known to facilitate the uptake of fatty acids into adipocytes. The deduced amino acid sequence from rat type II pneumocytes reveals 98% identity to the FAT/CD36 sequence obtained from rat adipocytes. The uptake of palmitate by type II pneumocytes follows Michaelis-Menten kinetics (Michaelis-Menten constant = 11.9 +/- 1.8 nM; maximum velocity = 62.7 +/- 5.8 pmol. min(-1). 5 x 10(5) pneumocytes(-1)) and decreases reversibly under conditions of ATP depletion to 35% of control uptake. Incubation of cells at 0 degrees C inhibited the uptake of palmitate almost completely, whereas depletion of potassium was without effect. Preincubation of the cells with bromobimane or phloretin decreases the uptake of palmitate significantly as does preincubation with sulfo-N-succinimidyl oleate, the specific inhibitor of FAT/CD36 (C. M. Harmon, P. Luce, A. H. Beth, and N. A. Abumrad. J. Membr. Biol. 121: 261-268, 1991). From these data, we conclude that FAT/CD36 is expressed in type II pneumocytes and mediates the uptake of palmitate in a saturable and energy-dependent manner. The data suggest that the uptake process is independent of the formation of coated pits and endocytotic vesicles.  (+info)

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1. (7/549)

Extracts of Hypericum perforatum (St. John's Wort) are widely used for the treatment of depressive disorders and are unspecific inhibitors of the neuronal uptake of several neurotransmitters. Previous studies have shown that hyperforin represents the reuptake inhibiting constituent. To characterize the mechanism of serotonin reuptake inhibition, kinetic analyses in synaptosomes of mouse brain were performed. Michaelis-Menten kinetics revealed that hyperforin (2 microM) induces a decrease in V(max) by more than 50% while only slightly decreasing K(m), indicating mainly noncompetitive inhibition. By contrast, citalopram (1 nM) leads to an elevation of K(m) without changing V(max). Monensin, a Na(+)/H(+) exchanger, showed similar properties as hyperforin (decrease of V(max) without changing K(m)). Compared with classical antidepressants, such as selective serotonin reuptake inhibitors and tricyclic antidepressants, hyperforin is only a weak inhibitor of [(3)H]paroxetine binding relative to its effects on serotonin uptake. As monensin decreases serotonin uptake by increasing Na(+)/H(+) exchange, we compared the effects of hyperforin and monensin on the free intracellular sodium concentration ([Na(+)](i)) in platelets by measuring 1,3-benzenedicarboxylic acid, 4,4'-[1,4,10-trioxa-7, 13-diazacyclopentadecan-7,13-diylbis(5-methoxy-6, 2-benzofurandiyl)]bis-, tetraammonium salt (SBFI/AM) fluorescence. Both drugs elevated [Na(+)](i) over basal levels, with a maximal [Na(+)](i) of 69 +/- 16.1 mM (50 microM hyperforin) and 140 +/- 9.1 mM (10 microM monensin). Citalopram at concentrations relevant for [(3)H]serotonin uptake inhibition had no effect on [Na(+)](i). Although the mode of action of hyperforin seems to be associated with elevated [Na(+)](i) similar to those levels found with monensin, the molecular mechanism might be different, as even at high concentrations, hyperforin does not elevate free intracellular sodium concentration ([Na(+)](i)) up to the extracellular level, as monensin does. Hyperforin represents the first substance with a known preclinical antidepressant profile that inhibits serotonin uptake by elevating [Na(+)](i).  (+info)

Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist. (8/549)

A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL.  (+info)

BICYCLO(2.2.2)OCTANE-2-METHYLAMINE, N,N-DIMETHYL-3-PHENYL-, HYDROCHLORIDE, (E)- | C17H26ClN | CID 40537 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
95685-44-2 - PEHOHEDRAIXEOC-UHFFFAOYSA-N - Bicyclo(3.2.1)octane-3-carboxamide, 3-ethyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki , 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from rat cortex and pituitary. Systemically administered CP-154,526 antagonizes the stimulatory effects of exogenous CRF on plasma ACTH, locus coeruleus neuronal firing and startle response amplitude. Potential anxiolytic activity of CP-154,526 was revealed in a fearpotentiated startle paradigm. These data are presented in the context of clinical findings, which suggest that CRF is hypersecreted in certain pathological states. We propose that a CRF antagonist such as CP-154,526 could affirm the role of CRF in certain psychiatric diseases and may be of significant value in the treatment of these disorders.. ...
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The IUPHAR/BPS Guide to Pharmacology. 3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Structure, properties, spectra, suppliers and links for: 3-[(1S,4S)-Bicyclo[2.2.1]hept-5-en-2-yl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfon.
40 CFR Part 180 [PP 0E3859/R2053; FRL-4772-7] Proposed Pesticide Tolerance for Procymidone AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. + ------------------------------------------------------------ SUMMARY: This document proposes to establish a tolerance for residues of the fungicide procymidone, N-(3,5-dichlorophenyl)1,2- dimethylcyclopropane-1,2-dicarboximide, in or on the raw agricultural commodity (RAC) wine grapes at 5.0 parts per million (ppm). This regulation to establish the maximum permissible level for residues of procymidone in or on wine grapes was requested in a petition submitted by Sumitomo Chemical Co., Ltd. DATES: Comments, identified by the document control number, [PP 0E3859/R2053], must be received on or before April 30, 1994. ADDRESSES: By mail, submit written comments to: Public Document and Freedom of Information Section, Field Operations Division (7506C), Office of Pesticide Programs, 401 M St., SW., Washington, DC 20460. In person, bring ...
Example 15) [(RS, 5SR, 6SR)-3-ethyl-6- (nitromethyl) bicyclo [3.2.0] hept-3-en-6-yl] ethyl acetate (racemic) Ethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] acetate (Racemate) [of 39] Diethyl [(RS, 5SR) -3-Ethylbicyclo [ 3.2.0] hept-3-en-6-ylidene] propanedioate (256.0 mg, 0.920 mmol) was dissolved in toluene (2.5 mL), was added DBU (152 mL), nitromethane (55 mL), at room temperature for 17 time it was stirred. After quenching with 1 M HCl (5 mL), and extracted three times with ethyl acetate (5 mL), and the resulting ethyl acetate solution was washed with saturated brine (5 mL). The solvent was evaporated under reduced pressure, as a pale yellow oily substance Diethyl [(1RS, 5SR, 6SR) -3-ethyl-6- (nitromethyl) bicyclo- [3.2.0] hept-3-en-6-yl] propanedioate was obtained (336.9 mg). The resulting Diethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] - Propanedioate a (336.9 mg) DMSO and (3.4 mL) It was dissolved in water (50 μL, 2.78 ...
Example 15) [(RS, 5SR, 6SR)-3-ethyl-6- (nitromethyl) bicyclo [3.2.0] hept-3-en-6-yl] ethyl acetate (racemic) Ethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] acetate (Racemate) [of 39] Diethyl [(RS, 5SR) -3-Ethylbicyclo [ 3.2.0] hept-3-en-6-ylidene] propanedioate (256.0 mg, 0.920 mmol) was dissolved in toluene (2.5 mL), was added DBU (152 mL), nitromethane (55 mL), at room temperature for 17 time it was stirred. After quenching with 1 M HCl (5 mL), and extracted three times with ethyl acetate (5 mL), and the resulting ethyl acetate solution was washed with saturated brine (5 mL). The solvent was evaporated under reduced pressure, as a pale yellow oily substance Diethyl [(1RS, 5SR, 6SR) -3-ethyl-6- (nitromethyl) bicyclo- [3.2.0] hept-3-en-6-yl] propanedioate was obtained (336.9 mg). The resulting Diethyl [(RS, 5SR, 6SR) -3-ethyl-6 (Nitromethyl) bicyclo [3.2.0] hept-3-en-6-YL] - Propanedioate a (336.9 mg) DMSO and (3.4 mL) It was dissolved in water (50 μL, 2.78 ...
4-Nitrophenyl bicyclo[4.1.0]heptane-7-carboxylate | C14H15NO4 | CID 579216 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione: a conformationally locked stavudine analog; structure in first source
You are viewing an interactive 3D depiction of the molecule [(1S,2R,3S,4R,5S)-2-(6-amino-2-chloro-purine-1,3,7-triium-9-yl)-3,4-dihydroxy-5-bicyclo[3.1.0]hexanyl]methyl dihydrogen phosphate (C12H15ClN5O6P) from the PQR.
You are viewing an interactive 3D depiction of the molecule 2-[(1S,2R,3S,4R,5R)-2-(6-amino-2-chloro-purine-1,3,7-triium-9-yl)-3,4-dihydroxy-5-bicyclo[3.1.0]hexanyl]ethylphosphonic acid (C13H17ClN5O5P) from the PQR.
This page contains information on the chemical 7-Oxabicyclo(4.1.0)hept-3-ene, 2,5-dibromo-, trans- including: 4 synonyms/identifiers.
2-Methoxy-6-(5,6,6-trimethyl-2-bicyclo[2.2.1]heptanyl)phenol/ACM20201756 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
CHEMVON BIOTECHNOLOGY: We are leading Manufacturer,Supplier & Exporter of (1R,5S,6R)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid,
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
CASSCF and CASPT2 calculations have been carried out on some of the thermal rearrangements of bicyclo[2.1.0]pentene (BCP), bicyclo[4.1.0]hepta-2,4-diene (BCH ...
Buy high quality (Z)-7-(((R)-2-Amino-2-carboxyethyl)thio)-2-(2,3-dimethylbut-3-enamido)hept-2-enoic Acid from toronto research chemicals Inc.
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Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate 843-59-4 route of synthesis, Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate chemical synthesis methods, Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate synthetic routes ect.
Role of hyperforin in diabetes and its associated hyperlipidemia in rats - hyperforin;diabetes;insulin;antihyperglycemic;antihyperlipidemic;antioxidant;
sodium,hexane-1-sulfonate 2832-45-3 safety info, sodium,hexane-1-sulfonate chemical safety search, Chemical sodium,hexane-1-sulfonate safety technical specifications ect.
Selim, S.; Gabriel, K., L.; Preiss, F., J., 1999: Absorption, distribution, metabolism, and excretion of N-octylbicycloheptene dicarboximide (MGK 264) administered orally to rats
The naked sugar (+)-(1R,4R)-7-oxabicyclo[2.2.1]hept-5-en-one ((+)-2) has been converted to D-lividosamine ((+)-i: 3-deoxy-D-glucosamine) and derivatives via (+)-2-chloro-2,3-dideoxy-5,6-O-iso-propylidene-D-arabino-hexono-1,4-lact one ((+)-33) and (4)-2-azido-2,3-dideoxy-5,6-O-isopropylidene-D-ribo-hexono-1,4-lactone ((+)-34) in a highly stereoselective fashion. Similarly, 2-acetamido-2,3-dideoxy-D-arabino-hexose and derivatives were derived from the naked sugar (-)-(1S,4S)-7-oxabicyclo[2.2.1]-hept-5-en-2-one ((-)-2) via the double hydroxylation of the C-C double bond in (-)-N-benzyl-N-[(1R,2S,4S)-6-bromo-7-oxabicyclo[2.2.1]hept-5-en-2-endo-y l]amine ((-)-40).. Keywords: Pure 7-oxabicyclo<2.2.1>hept-5-en-2-yl derivatives ; organic-synthesis ; d-glucosamine ; acid ; sugars ; efficient ; migration ; additions ; furan. Note: Univ lausanne,chim sect,2 rue barre,ch-1005 lausanne,switzerland.. ...
Schleyer, Paul v. R.; Kaufmann, Elmar; Kos, Alexander J.; Mayr, Herbert; Chandrasekhar, Jayaraman (1986): Stabilization of the alleged bishomoromatic bicyclo[3.2.1]octa-2,6-dienyl anion by counterion interactions and by hyperconjugation. In: Journal of the Chemical Society, Chemical Communications: pp. 1583-1585 ...
Water-soluble cyclic imide thione activated polyalkylene oxides having improved hydrolytic stability are disclosed. Methods of forming and conjugating the activated polyalkylene oxides with biologically active nucleophiles are also disclosed.
Article Biofilm carriers / MBBR carrier media and their respective diffusion depth. Within the biological wastewater treatment sector, it can increasingly be observed that biofilm carriers are applied in so-called Moving Bed Biofilm Reactors (MBBR). ...
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for (1S,4S)-2-phenyl-2,5-diazabicyclo[2.2.1]heptane (CAS No. 294177-33-6)
Pinene is another distinctive terpene and there are actually two different strains that are used.. Your CBD might contain either alpha-pinene or beta-pinene, although they are both derived from pine trees and the pleasant smell is unmistakable when it hits your nostrils.. The main benefits attached to both the alpha-pinene and beta-pinene is their anti-inflammatory properties. Pinene is also considered useful for people with respiratory issues such as asthma.. Love lavender?. The smell of lavender is very distinctive and is an aroma associated with calmness and relaxation.. Linalool is the terpene that is found in lavender and CBD products and other herbs enriched by it also include coriander, mint, and cinnamon. This particular compound is often used when the purpose is to reduce inflammation, help you to contend with arthritis, and help reduce the impact of seizures.. It might be suggested to you that if you use other herbs that contain linalool in addition to your chosen CBD product it could ...
ID 2: 382. Toxin: n. Trivial name: 2,​3-​Dithia-​5,​7-​diazabicyclo[2.2.2]​octane-​6,​8-​dione, 5,​7-​dimethyl-​1-​[[4-​[(3-​methyl-​2-​butenyl)​oxy]​phenyl]​methyl]​-​, (1R)​-; 2,​3-​Dithia-​5,​7-​diazabicyclo[2.2.2]​octane-​6,​8-​dione, 5,​7-​dimethyl-​1-​[[4-​[(3-​methyl-​2-​butenyl)​oxy]​phenyl]​methyl]​-​, (1R,​4R)​- (9CI); Dithiosilvatin; Dithiosilvatine. Systematic name: 2,​3-​Dithia-​5,​7-​diazabicyclo[2.2.2]​octane-​6,​8-​dione, 5,​7-​dimethyl-​1-​[[4-​[(3-​methyl-​2-​buten-​1-​yl)​oxy]​phenyl]​methyl]​-​, (1R,​4R)​-. Molecular formulae: C18 H22 N2 O3 S2. Molecular weight: 378.51. Chemical abstract number: 112269-38-2. Literature reference:. ...
Heptane Heptane Identifiers CAS number 142-82-5 RTECS number MI7700000 SMILES CCCCCCC Properties Molecular formula C7H16 Molar mass 100.21 g/mol Appearance
In the current bid for synthetic efficiency, multiple bond-forming transformations are becoming a key concept in organic synthesis. In this context, domino protocols have become increasingly common in the synthesis of bicyclic systems. This tutorial review aims at providing a short but authoritative overview
7,7-dimethyl-5-oxobicyclo[2.2.1]hept-2-en-1-yl acetate - chemical structural formula, chemical names, chemical properties, synthesis references
Structure, properties, spectra, suppliers and links for: (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino).
Group II metabotropic glutamate receptors (mGluR2 and mGluR3, encoded by GRM2 and GRM3) are implicated in hippocampal function and cognition, and in the pathophysiology and treatment of schizophrenia and other psychiatric disorders. However, pharmacological and behavioral studies with group II mGluR agonists and antagonists have produced complex results. Here, we studied hippocampus-dependent memory in GRM2/3 double knockout (GRM2/3-/-) mice in an iterative sequence of experiments. We found that they were impaired on appetitively motivated spatial reference and working memory tasks, and on a spatial novelty preference task that relies on animals exploratory drive, but were unimpaired on aversively motivated spatial memory paradigms. GRM2/3-/-mice also performed normally on an appetitively motivated, non-spatial, visual discrimination task. These results likely reflect an interaction between GRM2/3 genotype and the arousal-inducing properties of the experimental paradigm. The deficit seen on appetitive
Krystal JH, Abi-Saab W, Perry E, DSouza DC, Liu N, Gueorguieva R et al. (2005). Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology (Berl) 179: 303-309 ...
Materials. All tissue culture reagents were obtained from Invitrogen (Carlsbad, CA). G418 sulfate was obtained from Mediatech, Inc., (Herndon, VA). [3H]LY341495 (28.28 Ci/mmol) was obtained from American Radiolabeled Chemicals, Inc. (St Louis, MO). l-Glutamate, DCG-IV, l-AP4 [l-(+)-2-amino-4-phosphonobutyric acid], and LY341495 were obtained from Tocris (Ellisville, MO). Methotrexate was purchased from Calbiochem (La Jolla, CA). BINA was synthesized as described previously (Galici et al., 2006). The Calcium 3 Assay Kit was obtained from Molecular Devices (Sunnyvale, CA). The indicator dye fluo-4 was obtained from Invitrogen. Probenecid, dimethyl sulfoxide (DMSO), puromycin dihydrochloride, GDP, and guanosine 5′-3-O-(thio)triphosphate were purchased from Sigma-Aldrich, Inc., (St. Louis, MO). Unifilter-96 GF/B plates and MicroScint-20 were obtained from PerkinElmer Life and Analytical Sciences (Boston, MA). BioCoat poly-d-lysine 96-well culture plates were obtained from BD Biosciences Discovery ...
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0078] In a preferred embodiment of the method of the present invention the ring system formed by R1 and R2 is [0079] (i) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, spiro[3,3]heptyl, spiro[3,4]octyl, spiro[4,3]octyl, spiro[3,5]nonyl, spiro[5,3]nonyl, spiro[3,6]decyl, spiro[6,3]decyl, spiro[4,5]decyl, spiro[5,4]decyl, bicyclo[4.1.0]heptyl, bicyclo[3.2.0]heptyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl, bicyclo[5.1.0]octyl, bicyclo[4.2.0]octyl, bicyclo[5.3.0]decyl, octahydro-pentalenyl, octahydro-indenyl, decahydro-azulenyl, adamantly, or decahydro-naphthalenyl; optionally substituted 1 to 14 times, i.e. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 times, depending on the number of available valences with a substituent which is in each instance independently selected from the group consisting of halogen, in particular F, Cl, Br or I; --NO2; --CN; --OR6; --NR6R7; --COOR6; --CONR6R7; --NR8COR9; --NR8COR9; --NR8CONR6R7; --NR9SO2A; --COR6; ...
0033] Cyclic-olefin monomer which constitutes the foregoing resin has a structure indicated by a chemical equation 23, and examples of preferable monomer are, for example, bicyclo[2,2,1]hept-2-ene (norbornene), 5-methylbicyclo[2,2,1]hept-2-ene, 7-methybicyclo[2,2,1]hept-2-ene, 5-ethylbicyclo[2,2,1]hept-2-ene, 5-propylbicyclo[2,2,1]hept-2-ene, 5-n-butylbicyclo[2,2,1]hept-2-ene, 5-isobutylbicyclo[2,2,1]hept-2-ene, 1,4-dimethylbicyclo[2,2,1]hept-2-ene, 5-bromobicyclo[2,2,1]hept-2-ene, 5-chlorobicyclo[2,2,1]hept-2-ene, 5-fluorobicyclo[2,2,1]hept-2-ene, 5,6-dimethylbicyclo[2,2,1]hept-2-ene, dicyclopentadiene, tricyclopentadiene, tetracyclo[4,4,0,12.5,17.10]-3-dodecene, 5,10-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 2,10-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 11,12-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 2,7,9-trimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, 9-ethyl-2,7-dimethyltetracyclo[4,4,0,12.5,17.10]-3-dodecene, ...
ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [OPP-300225C; FRL-3886-3] RIN 207C-AB78 Pesticide Tolerance for Procymidone AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This document establishes a time-limited tolerance for residues of the fungicide procymidone, N-(3,5- dichlorophenyl)-l,2- dimethylcyclopropane l,2- dicarboximide, in or on the raw agricultural commodity (RAC) wine grapes grown prior to January 1, 1990, at 7.0 parts per million (ppm). Sumitomo Chemical Co., Ltd., petitioned EPA to establish a maximum permissible level for residues of procymidone on grapes. EFFECTIVE DATE: This regulation becomes effective April 26, 1991. ADDRESSES: Written objections, identified by the document control number, [OPP-300225C], may be submitted to: Hearing Clerk (A-110), Environmental Protection Agency, Room 3708, 401 M St.,SW., Washington, DC 20460. FOR FURTHER INFORMATION CONTACT: By mail: Susan Lewis, Product Manager (PM) 21, (H7505C), Registration Division ...
Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD.. Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA.. Group II metabotropic glutamate (mGlu) receptor agonists, including (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), have demonstrated efficacy in animal models of anxiety and schizophrenia, and LY354740 decreased anxiety in human subjects. Herein, we report the in vitro pharmacological profile and pharmacokinetic properties of another potent, selective, and structurally novel mGlu2/3 receptor agonist, (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039) and provide comparisons with LY354740. Similar to LY354740, LY404039 is a nanomolar potent agonist at recombinant ...
Find quality suppliers and manufacturers of 508208-63-7(1H-Pyrrolo[2,3-c]pyridine-5-carboxamide,N-2-azabicyclo[2.2.1]hept-6-yl-) for price inquiry. where to buy 508208-63-7(1H-Pyrrolo[2,3-c]pyridine-5-carboxamide,N-2-azabicyclo[2.2.1]hept-6-yl-).Also offer free database of 508208-63-7(1H-Pyrrolo[2,3-c]pyridine-5-carboxamide,N-2-azabicyclo[2.2.1]hept-6-yl-) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Hyperforin is a plant-derived compound that has been found useful in the treatment of depression. In fact, this phytochemical was shown to be superior to popular antidepressants such as Prozac. What is this natural compound extracted from St. Johns wort? How does it improve the symptoms of depression and what are the main studies to back its claim? How should it be used? Read on to find the answers to these questions.
Phytopathology 92:75-80...Phytopathology 92:75-80...A Point Mutation in the Two-Component Histidine Kinase BcOS-1 Gene Confers Dicarboximide Resistance in Field Isolates of Botrytis cinerea...Michiyo Oshima , Makoto Fujimura , Shinpei Banno , Chigusa Hashimoto , Takayuki Motoyama , Akihiko Ichiishi , and Isamu Yamaguchi...
Buy high quality (1R,5S,6R)-rel-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester 347378-74-9 from toronto research chemicals Inc.
TY - JOUR. T1 - Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells. AU - Jung, Hye Jin. AU - Kim, Yonghyo. AU - Chang, Junghwa. AU - Kang, Sang Won. AU - Kim, Jeong Hun. AU - Kwon, Ho Jeong. N1 - Funding Information: Acknowledgments We are grateful to Young-Guen Kwon for technical assistance with the Matrigel plug assay and Paul Schumacker, Natalie Ahn, and James Chen for critical comments. This study was partly supported by grants from the National Research Foundation of Korea funded by the Korean Government (MEST; 2009-0092964, 2010-0017984, 2012M3A9D1054520), the Translational Research Center for Protein Function Control, KRF (2009-0083522), the Center for Food and Drug Materials of Agriculture Science & Technology Development (PJ0079772012), Rural Development Administration, National R&D Program, Ministry of Health &Welfare (0620360-1), and the Brain Korea 21 Project, Republic of Korea.. PY - 2013/9. Y1 - 2013/9. N2 - Vascular endothelial growth factor (VEGF) signal ...
Comprehensive supplier list for rel-(1R,4R)-5-aminobicyclo[2.2.1]heptane-2-carboxylic acid,rel-(1R,4R,5S)-tert-Butyl 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate
CHEMVON BIOTECHNOLOGY: We are leading Manufacturer,Supplier & Exporter of (1S,3S,5S)-3-(AMinocarbonyl)-2-azabicylo[3.1.0]hexane-2-carboxylic acid tert-butyl ester,
Fig. 3.Mean absolute and relative power spectra. The graphs show the effects of ketamine 30 mg/kg (KET), LY379268 3 mg/kg (LY), the vehicle (VEH) and co-administration of ketamine 30 mg/kg + LY379268 3 mg/kg (KET/LY) on the absolute (a) and relative (b) power spectra. For better graphical presentation, data are expressed per 1 Hz as the percent change of their corresponding baseline with ±SEM × 100 / mean power of the corresponding baseline. Thus, all baselines are represented by the X axis (the zero line). Significant differences of mean power within the whole spectral bands of each treatment compared to the vehicle are shown in the upper part of the figure (ANCOVA). The direction of change is indicated by arrows. The ketamine-induced increase of low-gammaand the decrease in delta and theta powerwere reversed by LY379268. The decrease in beta andhighpower in LY379268was also observed in the ketamine + LY379268 treated animals. *** indicates p b 0.001 for ketamine 30 mg/kg vs the vehicle. ‡‡‡
Get to know what is Pinene and earn about the effects and benefits of Pinene as the ban on marijuana is slowly but surely becoming a thing of the past.
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Creative-Proteomics offer cas 3615-44-9 D-manno-[UL-13C7]hept-2-ulose D-manno-[UL-13C7]heptulose. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
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Pinene The chemical compound pinene is a bicyclic terpene (C10H16, 136.24 g/mol ) known as a monoterpene [1]. There are two structural isomers found in nature:
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Définitions de 1 2 nitrophenoxy octane, synonymes, antonymes, dérivés de 1 2 nitrophenoxy octane, dictionnaire analogique de 1 2 nitrophenoxy octane (anglais)
Listing of chemicals .alpha.-Pinene oxide through 1H-Androstano(3,2-c)pyra with links to more detailed information for each chemical.
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An Iodine catalyzed (3, 5)-thionium-ene-type cyclization for the facile construction of various multisustituted tetrahydrothiopyrans was successfully developed from aldehyde (aromatic and aliphatic) and 6-methylhept-5-en-2thiol, 6-methyl-2-phenyl hept-5-en-2-thiol and 2, 6-dimethylhept-5-en-2-thiol in the presence of iodine under mild and neutral conditions. This method is simple, convenient and cost-effective.
Chevrolet extends its reach into supercar territory with the new 2015 Z06. This bad boy gets its get up and go from an intensely powerful supercharged 625h...
... (also known as bicyclo[2.2.1]heptane) is an organic compound and a saturated hydrocarbon with chemical formula C7H12 ... and is a bridged bicyclic compound. The compound is a prototype of a class of strained bicyclic hydrocarbons. The compound was ... It is a crystalline compound with a melting point of 88 °C. The carbon skeleton is derived from cyclohexane ring with a ... das Bicyclo-[1.2.2]-heptan, und die stereoisomeren Norborneole". Naturwissenschaften. 22: 171. doi:10.1007/BF01496254. ...
... (decahydronaphthalene, also known as bicyclo[4.4.0]decane and sometimes decaline), a bicyclic organic compound, is an ...
... octane Bicyclo[3.3.0]octane (polyquinane) Bicyclo[3.2.1]octane https://pubchem.ncbi.nlm.nih.gov/compound/Bicyclo_3.2.1_octane ... 7-Octadiene Octynes 1-Octyne 2-Octyne 3-Octyne 4-Octyne Bicyclooctane Bicyclo[2.2.2] ...
Instead, the group proposed the structure of the bicyclo[5.1.0]octadienyl compound, theorizing that the cyclopropane bond ... Similarly, a substituted bicyclo[3.2.1]octa-3,6-dien-2-yl cation (the 2-(4'-Fluorophenyl) bicyclo[3.2.1]oct-3,6-dien-2-yl ... These anionic compounds are often prepared from their neutral parent compounds through lithium metal reduction. 1,2- ... Just as aromatic compounds exhibit exceptional stability, antiaromatic compounds, which deviate from Huckel's rule and contain ...
Bicyclo[1.1.1]pentane is an organic compound, the simplest member of the bicyclic bridged compounds family. It is a hydrocarbon ... Bicyclo[1.1.1]pentane is a highly strained molecule. Kenneth Wiberg and Frederick Walker used bicyclo[1.1.1]pentane to make [ ... The bicyclo[1.1.1]pentane structure has been used as an unusual bioisostere for a phenyl ring. Housane Wiberg, Kenneth B.; ... "Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally ...
One demonstration of this principle is found in the two bicyclic compounds depicted below. The one on the left is a bicyclo[2.2 ... Rickert Reaction in the Structures of Bicyclo[2.2.2]octadiene and Bicyclo[2.2.2]octene Derivatives". The Journal of Organic ... Compared to the compound on the right (which, lacking an alkene group, is unable to give this reaction) the bridgehead carbon- ... For these two compounds the prediction holds up based on X-ray crystallography. One way that enzymatic catalysis proceeds is by ...
Reaction of organic compounds under high temperature - dilute acid (HTDA) conditions. III. The perdeuteration of bicyclo[2.2.1] ... Commercially available, this colorless compound may be prepared by the reaction of norbornene with formic acid, followed by ...
With this reaction, compounds with bicyclo skeletons can be synthesized, e.g. a diester with a norbornene (bicyclo[2.2.1] ... The compound (and its metabolite, monomethyl fumarate) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway ... As a α,β-unsaturated electrophilic compound, dimethyl fumarate is rapidly attacked by the detoxifying agent glutathione (GSH) ... Boyland, E; Chasseaud, LF (1967). "Enzyme-catalysed conjugations of glutathione with unsaturated compounds". The Biochemical ...
Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects. Some also act as agonists at ... stereochemistry and anti-tetrabenazine activity of bicyclo analogues of 2-phenylmorpholines". Journal of Heterocyclic Chemistry ... Some compounds have also become subject to illicit use as designer drugs. Substituted amphetamine Substituted benzofuran ... NIH PubChem Compound Summary for CID 3283983 Media related to Substituted phenylmorpholines at Wikimedia Commons. ...
Well-defined organometallic compounds have mainly been investigated for small-scale reactions or in academic research. The ... Michelotti, Francis W.; Keaveney, William P. (1965). "Coordinated Polymerization of the Bicyclo-(2.2.1)-heptene-2 Ring System ( ... In any of the pairwise mechanisms with olefin pairing as rate-determining step this compound, a secondary reaction product of ... Tebbe, F. N.; Parshall, G. W.; Reddy, G. S. (1978). "Olefin homologation with titanium methylene compounds". Journal of the ...
Bicyclo(2.2.1)heptane-2-carbonitrile. *Biotin hydrazide. *2,3-Bis(acetylmercaptomethyl)quinoxaline ... This category is for stub articles relating to organic compounds. You can help by expanding them.. To add an article to this ... Pages in category "Organic compound stubs". The following 200 pages are in this category, out of approximately 1,151 total. ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Organic_compound_stubs&oldid=734103263" ...
The scope of definitions and the range of compounds included may vary substantially between jurisdictions, so compounds which ... bicyclo[2.2.1]heptanyl, 1,2,3,4-tetrahydronaphthyl, quinolinyl, isoquinolinyl, 1-amino-1-oxopropan-2-yl, 1-hydroxy-1-oxopropan- ... and so does not include compounds such as O-1871 which lacks the cyclohexyl OH group, or compounds such as JWH-337 or JWH-344 ... Benzoylindoles: Any compound containing a 3-(benzoyl)indole structure with substitution at the nitrogen atom of the indole ring ...
... or bicyclo[1.1.0]buta-1,3-diene is a polycyclic hydrocarbon composed of two fused cyclopropene rings. Computational ... D. P. Craig (1951). "cycloButadiene and some other pseudoaromatic compounds". J. Chem. Soc.: 3175-3182. doi:10.1039/ ...
As an oxygen-rich compound of carbon and nitrogen, it is predicted to have explosive properties,[2] but to be too thermally ... The all-carbon analog (bicyclo[1.1.1]pentane) and other elemental variations of this ring structure have been synthesized. ... The nitratoxycarbon functional group itself has yet to be observed in any chemical compound. Computational chemistry studies ... and nitrate compounds and their potential as high energy materials". Computational and Theoretical Chemistry. 979: 33-37. doi: ...
... bicyclo-[4.3.0]non-8-en-2-one". Organic Syntheses. 66: 8. doi:10.15227/orgsyn.066.0008. Alfred Hassner; C. Stumer (2002). ... New Annulation Approaches to Five and Six-Membered Carbocyclic Compounds". Tetrahedron Letters. 26 (21): 2513. doi:10.1016/ ...
The reactivity of organomanganese compounds can be compared to that of organomagnesium and organozinc compounds. The ... 10191 Transition metal bicyclo[2.2.1]hept-1-yls Barton K. Bower, Howard G. Tennent J. Am. Chem. Soc., 1972, 94 (7), pp 2512- ... The Mn(I) compound BrMn(CO)5 is also the precursor to many pi-arene complexes: BrMn(CO)5 + Ag+ + C6R6 → [Mn(CO)3(C6R6)]+ + AgBr ... Several organomanganese compounds with valency +3 or +4 are known. The first one discovered (1972) was Mn(nor)4 with four ...
This compound has the best antibacterial activity of Endiandrianic acid A-G compounds. Endiandric acid C was tested towards ... or the fully cyclized bicyclo[4.2.0]octadiene (bicyclic diol) 17. Remarkably, following this 3-6 hour, 25 °C process, a 45-55% ... The title compound was then pursued via DIBAL reduction of the nitrile at low temperature, followed by mild acidic hydrolysis ... Two units of malonyl CoA are then added to through the acetate pathway 3. Compound 3 is then reduced to the di-enol form that ...
Synthesis of aza-bicyclo[3.2.1]octane and aza-bicyclo[3.2.2]nonane ethers, imides, and amines". The Journal of Organic ... NS2214 appears to have been abandoned now, RTI-336 was their latest compound. RTI decided that they wanted to make all 8 ... To solve the problem of the unexpected aza-bicyclo[3.2.2]nonane rearrangement product, the original synthesis had to be ... and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product". ...
Agostic interactions in transition metal compounds. Proceedings of the National Academy of Sciences of the United States of ... Direct observation of methyl-substituted 7-norbornadienyl and bicyclo[3.2.0]heptadienyl cations. Journal of the American ...
First, α-diazocarbonyl compounds are in an equilibrium of s-cis and s-trans-conformers, the distribution of which may influence ... CS1 maint: Multiple names: authors list (link) Horner, L. Spietschka, E. (1955). "Über Lichtreaktionen IV1): Bicyclo-[1.1.2]- ... α-diazocarbonyl compounds are generally locally planar, with large rotational barriers (55-65 kJ/mol) due to C-C olefin ... Generally, under photolysis, compounds in the s-cis conformation react in a concerted manner due to the antiperiplanar ...
Symmetrical cyclooctynes such as BCN (bicyclo[6.1.0]nonyne) form a single regioisomer upon cycloaddition and may serve to ... and it has also been used in the generation of SPECT imaging compounds. More recently, the use of an oxanorbornadiene was ... The reaction must be selective between endogenous functional groups to avoid side reactions with biological compounds ... imaging agents which must be made quickly with high purity and yield in order to minimize isotopic decay before the compounds ...
This result suggested that there is a high selectivity for the 3° hydrogen, but the intermediate tertiary chloro compound 17 is ... Esposito, G.; Furstoss, R.; Waegell, B. (1971). "Synthese de la methyl-6, aza-6, bicyclo (3,2,1) octanone-4". Tetrahedron Lett ... Synthesis of 1,4-epimine compounds". J. Org. Chem. 48 (23): 4430-4432. doi:10.1021/jo00171a066. De Armas, P.; Carrau, R.; ... Part 4. Intramolecular functionalization of N-nitroamine radicals: synthesis of 1,4-nitroimine compounds". J. Chem. Soc., ...
This compound rearranges thermally to 1 with a half-life of ≥ 2 h at 360 °C, as compared with the parent hydrocarbon that ... 1,3]-Sigmatropic shifts for 5-X-bicyclo[2.1.0]pent-2-enes. An evaluation of the pseudopericyclic model". Journal of the ... In 1970, he chaired the GRC conference on Hydrocarbon Chemistry, in 1971 the GRC on Heterocyclic Compounds; he was a member of ... Highly strained and highly reactive alkenes bicyclo[2.2.0]hex-1(4)-ene (13) and its perfluoro counterpart 14 provide another ...
... and aza-bicyclo[2,1,1]hexanes". J. Chem. Soc. D. 19: 1167. doi:10.1039/C29710001167. Corey, E. J.; Kang, M. C.; Desai, M. C.; ... many intramolecular reactions that would not occur as an intermolecular reaction between two compounds take place. Examples of ... reactions have been used to synthesize organic compounds with interesting ring systems and topologies. For example, [2+2] ...
The first step includes a reaction between a compound containing acidic C-H hydrogens, an aldehyde and a primary amine, using a ... "An electron diffraction study of the molecular structure of gaseous bicyclo[3.3.1]nonane". J. Mol. Struct. 52 (1): 211-224. ... Bispidine (3,7-diazabicyclo[3.3.1]nonane) is an organic compound that is classified as a bicyclic diamine. Although synthetic, ... compounds with tetradentate ligands based on the bispidine backbone". Journal of the Chemical Society, Dalton Transactions (23 ...
This compound is stable in the solid state for a week but decomposes in contact with air. Its synthesis started from ... a, Diels-Alder reaction of dibromonaphthalene forming a naphthyne and bicyclo[2,2,2]oct-2,3,5,6,7-pentaene with n-butyllithium ... This compound has long been pursued by chemists because of its potential interest in electronic applications and was first ... Heptacene is an organic compound and a polycyclic aromatic hydrocarbon and the seventh member of the acene or polyacene family ...
This can be attributed to a field effect because in the same compound with the chlorines pointed away from the acidic group the ... Cole, Thomas W.; Mayers, Carolyn J.; Stock, Leon M. (1974). "Chemistry of the bicyclo[2.2.2]octanes. XV. Dissociation constants ... These effects can therefore help to tune the acidity/basicity of a molecule to protonate/deprotonate a specific compound, or ... For example, the three compounds to the right, all octanes, differ only in the number of linkers between the electron ...
The photon is however not absorbed by the organic compound, but by chlorine. Photolysis of Cl2 gives chlorine atoms, which ... the type B bicyclo[3.1.0]hexanone rearrangement to phenols, photochemical electrocyclic processes, the rearrangement of ... Wirz Photochemistry of Organic Compounds: From Concepts to Practice. Wiley, Chichester, 2009, ISBN 978-1405190886. N. J. Turro ...
Using the same rhodium(I) catalyst and C-C bond activation strategy one can access compounds with fused rings. Once again the ... Practical Approach to Bicyclo[3.3.0]octenes". Journal of the American Chemical Society. 125 (31): 9282-9283. doi:10.1021/ ... "Rhodium Catalyzed Transformation of 4-Pentynyl Cyclopropanes to Bicyclo[4.3.0]nonenones via Cleavage of Cyclopropane Ring". ... One-Step Construction of Multifunctional Angular Tricyclic 5/5/6 Compounds". Journal of the American Chemical Society. 133 (6 ...
... is an acid-labile compound. Acid-labile compounds are more easily broken down in acidic environments, so the ... N,N-dimethyl-2-([(1R,4R,6S)-1,7,7-trimethyl-6-phenyl-6-bicyclo[2.2.1]heptanyl]oxy)ethanamine ... "Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative". Arzneimittel- ...
"Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488-1493. PMID ... Reposal, 5-Ethyl-5-(bicyclo(3.2.1)octenyl)barbituric acid Farmakoinformacioni podaci ...
Most carbon compounds CO2 Carbon dioxide Determining the point group is a useful way to predict polarity of a molecule. In ... Examples of household nonpolar compounds include fats, oil, and petrol/gasoline. Therefore, most nonpolar molecules are water- ...
Brasofensine was made "class A" in the UK under the MDA (misuse of drugs act). BF is an interesting compound in so far as the ... n-dimethylaminomethyl-bicyclo-2,2,2-octane, hydrochloride". Life Sciences. 23 (10): 1041-7. doi:10.1016/0024-3205(78)90664-1. ... This is based on the fact that the compound is bicyclic and therefore does not adhere to the equation given above. It is ... Hence, this might be viewed as a strategy for increasing the safety of the compounds and would also be preferable to use in ...
MacKenzie, DA; Pezacki, JP (2014). "Kinetics studies of rapid strain- promoted [3+2] cycloadditions of nitrones with bicyclo[ ...
Intercalation compounds are not 3-dimensional, unlike clathrate compounds.[6] According to IUPAC, clathrates are "Inclusion ... Usually, clathrate compounds are polymeric and completely envelop the guest molecule. Inclusion compounds are often molecules, ... Two potassium graphite compounds are KC8 and KC24. Carbon fluorides (e.g., (CF)x and (C4F)) are prepared by reaction of ... J. L. Atwood "Inclusion Compounds" in Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim. doi: 10.1002/ ...
Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State ... Reposal, 5-Ethyl-5-(bicyclo(3.2.1)octenyl)barbituric acid. Hemijski podaci. ...
... s are seen in many boron compounds, such as diborane (B2H6). The monomer BH3 is unstable since ... This type of bond also occurs in carbon compounds, where it is sometimes referred to as hyperconjugation; another name for ...
Ionic compounds conduct electricity when molten or in solution, typically as a solid. Ionic compounds generally have a high ... Many sulfides, e.g., do form non-stoichiometric compounds. Many ionic compounds are referred to as salts as they can also be ... Main article: Ionic compound. Ionic compounds in the solid state form lattice structures. The two principal factors in ... obey the rules of stoichiometry despite not being molecular compounds. For compounds that are transitional to the alloys and ...
These compounds can be liquid until a certain temperature, then solid even as the temperature increases, and finally liquid ... Lipinski CA (December 2004). "Lead- and drug-like compounds: the rule-of-five revolution". Drug Discovery Today: Technologies. ... Increase in the melting point, boiling point, solubility, and viscosity of many compounds can be explained by the concept of ... The hydrogen bond is responsible for many of the anomalous physical and chemical properties of compounds of N, O, and F. In ...
Half-cell potential of aromatic compounds against the SCE (Fc+/0)[24] Compound Potential (V) ... Housane (bicyclo[2.1.0]pentane). *Norbornane (bicyclo[2.2.1]heptane). *Decalin (bicyclo[4.4.0]decane) ... Compounds derived from biogenic precursors during early diagenesis". Geochimica et Cosmochimica Acta. 44 (3): 415-429. Bibcode: ... A polycyclic aromatic hydrocarbon (PAH) is a hydrocarbon-a chemical compound containing only carbon and hydrogen-that is ...
Solubility and compound formation. Metals are insoluble in water or organic solvents unless they undergo a reaction with them. ... Some intermetallic materials e.g. do exhibit metal clusters, reminiscent of molecules and these compounds are more a topic of ... Despite all this progress, the nature of intermetallic compounds and alloys largely remained a mystery and their study was ... One could call these materials metal compounds, but, because materials with metallic bonding are typically not molecular, ...
"IR-9.2.4.1 Coordination Compounds: Describing the Constitution of Coordination Compounds: Specifying donor atoms: General" (PDF ... Historically important compounds where the ligands are described with hapticity[edit]. *Ferrocene - bis(η5-cyclopentadienyl) ... W(CO)3(PPri3)2(η2-H2 ) - the first compound to be synthesized with a dihydrogen ligand.[8][9] ... Reduction of the 18-VE compound [Ru(η6-C6Me6)2]2+ (where both aromatic rings are bonded in an η6-coordination), results in ...
Lam, Jørgen (1988). Chemistry and biology of naturally-occurring acetylenes and related compounds (NOARC): proceedings of a ... Housane (bicyclo[2.1.0]pentane). *Norbornane (bicyclo[2.2.1]heptane). *Decalin (bicyclo[4.4.0]decane) ... These compounds are highly bioactive, e.g. as nematocides.[12] 1-Phenylhepta-1,3,5-triyne is illustrative of a naturally ... However, inorganic compounds featuring unsaturation in the form of triple bonds may be denoted by substitutive nomenclature ...
... is an organic compound with formula C. 10H. 8. It is the simplest polycyclic aromatic hydrocarbon, and is a white ... Bicyclo[6.2.0]decapentaene is a structural isomer with a fused 4-8 ring system[18] and azulene is another, with a fused 5-7 ... Is bicyclo[6.2.0]decapentaene aromatic or antiaromatic?". J. Org. Chem. 50 (15): 2684-2688. doi:10.1021/jo00215a018.. ... Seidell, Atherton; Linke, William F. (1919). Solubility of Inorganic and Organic Compounds (2nd ed.). New York: D. Van Nostrand ...
Also note: methylcyclopropane is yet a different chemical compound, which is a cycloalkane with the formula C4H8. ... Housane (bicyclo[2.1.0]pentane). *Norbornane (bicyclo[2.2.1]heptane). *Decalin (bicyclo[4.4.0]decane) ... Sisler E.C., Serek M. (2003). "Compounds interacting with the ethylene receptor in plants". Plant Biol. 5 (5): 473-80. doi: ... Synthesis Methods, Complexes and Delivery Methods for the Safe and Convenient Storage, Transport and Application of Compounds ...
Bicyclo[3.1.0]hexan-2-one , C6H8O , CID 549294 - structure, chemical names, physical and chemical properties, classification, ...
Bicyclo[2.2.1]hept-5-en-2-yl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfon. ... Drugs or Compounds in Development. Imaging Agents. Information Aggregators. Journal Publishers via MeSH. ... 1S,4S)-bicyclo[2.2.. 1]hept-5-én-2-yl]-6. -chloro-3,4-dihydro. -2H-1,2,4-benzothia. diazine-7-sulfonami. de [French] [ACD/IUPAC ... 3-[(1S,4S)-Bicyclo[. 2.2.1]hept-5-en-2-y. l]-6-chlor-3,4-dihy. dro-2H-1,2,4-benzot. hiadiazin-7-sulfona. mid-1,1-dioxid [German ...
... bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione: a conformationally locked stavudine analog; structure in ... Polycyclic Compounds: 56*Bridged Compounds: 3*Bicyclo Compounds*1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3- ... Bridged Compounds: 3*Bicyclo Compounds*1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4- ... 1-Ring Heterocyclic Compounds*Pyrimidines: 319*Pyrimidine Nucleosides: 41*Thymidine: 3933*1-(5-(hydroxymethyl)bicyclo(3.1.0)hex ...
3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol ligand page. Quantitative data and detailed annnotation of the targets of licensed ... Compound class. Synthetic organic IUPAC Name 3-(6-bicyclo[2.2.1]heptanyl)benzene-1,2-diol. ... Name: 3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol ...
... the title compound (as free form): 12.5 min diastereoisomers Marr (Compound X): 13.5 min double bond position isomer (compound ... Bicyclo(3.2.0)hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-, benzenesulfonate (1:1). SEE. Tert-butyl [(1R,5S, ... Formula (V) or a compound having the general formula (VI) from (and / or its enantiomer) is a process for preparing a compound ... In this step, (1) with respect to (Va) compound with (and its enantiomers), directly to a compound of formula (VIa) with the ...
Bicyclo Compounds. *Biphenyl Compounds. *Biphenyl Compounds: therapeutic use. *Carbolines. *Carbolines: therapeutic use ...
Bridged Bicyclo Compounds / pharmacology * Calcimycin / pharmacology * Calcium / metabolism * Dose-Response Relationship, Drug ...
Bridged Bicyclo Compounds, Heterocyclic / metabolism * DNA-Binding Proteins / genetics * DNA-Binding Proteins / metabolism* ...
Bicyclo Compounds / pharmacology. Cyclooxygenase 1 / metabolism. Cyclooxygenase 2 / drug effects, metabolism. Cyclooxygenase 2 ... 0/Bicyclo Compounds; 0/Cyclooxygenase 2 Inhibitors; 0/Hexanoic Acids; 0/Lactones; 0/Membrane Proteins; 0/ONO 8711; 0/Ptgir ...
PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ... Aza Compounds / pharmacology*. Bicyclo Compounds, Heterocyclic / pharmacology*. Breast Neoplasms / metabolism*. Cell Line, ... 0/2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one; 0/Antineoplastic Agents; 0/Aza Compounds; 0/Bicyclo Compounds, ... PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ...
0 (Actins); 0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Thiazolidines); 22144-77-0 (Cytochalasin D); EC 3.6.1.- (Myosin ...
0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (PCI 32765); 0 (Purines); 0 (Pyrazoles); 0 (Pyrimidines); 0 (Quinazolinones); 0 ...
Random copolymer containing derivative of bicyclo [2.2.1] hept-2-ene compound. ... comprising titanium compounds and organoaluminum compounds or vanadium-containing catalysts comprising vanadium compounds and ... Ethylene/bicyclo(2.2.1)hept-2-ene copolymers. US4573994. Dec 7, 1981. Mar 4, 1986. The Johns Hopkins University. Refillable ... 0 556 034 discloses a medical instrument of a material containing a resin of a cyclic olefin compound or a bridged polycyclic ...
BICYCLO COMPOUNDS/METABOLISM BLUE GREEN ALGAE CHLOROBI CHROMATIUM CYANOBACTERIA DISULFIDES DISULFIDES/ANALYSIS EUKARYOTES ... BICYCLO COMPOUNDS/METABOLISM; CHLOROBI; CHROMATIUM; CYANOBACTERIA; DISULFIDES/ANALYSIS; EUKARYOTIC CELLS; OXIDATION-REDUCTION; ... BACTERIA/CHEMISTRY/METABOLISM; EVOLUTION; GLUTATHIONE/METABOLISM; SULFHYDRYL COMPOUNDS/ANALYSIS; ALGAE, GREEN; BACTERIAL ...
The simplest member is the bicyclic compound bicyclo[3.3.0]octane. Other members are triquinacene and dodecahedrane. The ... and also as part of a failed attempt to synthesize the then-elusive and much-coveted compound dodecahedrane. Unlike the related ... compound triquinacene (tricyclo[5.2.1.-04,10]deca-2,5,8-triene) is the second member of a family of polyquinenes. It was ...
The standard enthalpies of formation of bicyclo compounds. 2. Bicyclo[3.3.1]nonane and bicyclo[3.3.2]decane, J. Chem. Thermodyn ... The Standard Enthalpies of FOrmation of Bicyclo Compounds 2. Bicyclo[3.3.1] nonane and Bicyclo[3.3.2]decane, J, Chem. Thermodyn ... Steele, W.V., The standard enthalpies of formation of bicyclic compounds. IV. Bicyclo[2.2.1]heptan-2-one and bicyclo[2.2.1] ... Steele, W.V., The Standard Enthalpies of Formation of Bicylclic Compounds IV. Bicyclo[2,2,1]heptan-2-one and Bicyclo[2.2.1] ...
Categories: Bicyclo Compounds, Heterocyclic Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
... can include multi-cyclo compounds such as bicyclo and tricyclo compounds. It should be understood that two bridging bonds will ... For example, the bicyclo compounds that are generally defined by formula (I) can more specifically be represented by formulas ( ... As an example, two R2 bridging bonds can form a bridge across the cyclic amino ring, and thereby create a bicyclo compound. ... Accordingly, it should also be understood that the Z containing moiety can be tethered to the bicyclo compound in the one ring ...
Bicyclo Compounds [D04.075.080]. *Bicyclo Compounds, Heterocyclic [D04.075.080.875]. *Azabicyclo Compounds [D04.075.080.875.099 ...
Substituted bicyclo [2.2.2] oct/5-ene compounds and their use as cooling agents. April, 2009. Galopin et al. ... Without the sulfites, browning is observed at 55° C. after 1 month of storage, and in the absence of all of the compounds ... Of course, one skilled in this art will select this or these optional additional compounds, and/or their amount, in such manner ... The following are representative non-limiting examples of surface-active wetting agents: compounds of the poloxamer class and ...
CID 17575653 | C8H12O2 | CID 17575653 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Compounds having [2.2.1] bicyclo skeleton US6330446B1 (en) * 1998-04-08. 2001-12-11. Oki Electric Industry Co., Ltd.. Velocity- ... Compounds having [2.2.1] bicyclo skeleton US6272344B1 (en) 1998-06-09. 2001-08-07. Nec Corporation. Position registration ...
Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. In between the ... Therefore, fused bicyclic compounds have a "0" included in the brackets. For example, decalin is named bicyclo[4.4.0]decane. ... An example of a spirocyclic compound is the photochromic switch spiropyran. In fused bicyclic compounds, two rings share two ... When naming simple fused bicyclic compounds, the same method as for bridged bicyclic compounds is applied, except the third ...
Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating ... which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. ... Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, ... tetrahydrothiophenyl, tetrahydrothiopyranyl, and the like; and polycyclicheterocyclyl compounds, for example, a bicyclo moiety ...
6 Nomenclature of Unsaturated Compound (Alkenes/Alkynes), Bicyclo compounds 64 Min. 7 Nomenclature of Spiro Compounds, ... 9 Multiple Functional Group Compounds, Aromatic Compounds Nomenclature, Common Names 55 Min. ... 1Classification and Nomenclature of Organic Compound 1 Bonding and Hybridisation of Carbon 55 Min. ... 3 Identification of Functional Groups, Homocyclic and Heterocyclic Compound, Homologous Series 47 Min. ...
With this reaction, compounds with bicyclo skeletons can be synthesized, e.g. a diester with a norbornene (bicyclo[2.2.1] ... The compound (and its metabolite, monomethyl fumarate) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway ... As a α,β-unsaturated electrophilic compound, dimethyl fumarate is rapidly attacked by the detoxifying agent glutathione (GSH) ... Boyland, E; Chasseaud, LF (1967). "Enzyme-catalysed conjugations of glutathione with unsaturated compounds". The Biochemical ...
C. Bicyclo[3.3.0]octane-2,6-dione. (Compound 4; (Note 10).) Diol 3, 12.6 g (0.089 mol), is placed in a 250-ml, three-necked, ... B. Bicyclo[3.3.0]octane-2,6-diol. (Compound 3; (Note 5).) An ice-cooled aqueous 10% solution of sodium hydroxide (100 mL) is ... A. 2,6-Diacetoxybicyclo[3.3.0]octane. (Compound 2; (Note 1) and (Note 2).) An ovendried. 1-L round-bottomed flask, equipped ... Bicyclo[3.3.0]octane-2,6-dione has been known since 1934,10 but extant procedures for large-scale multigram synthesis of this ...
3 naming of compound having only one functional group 68 Min. 4 Naming of poly function group,cyclo,bicyclo compound,spiro comp ...
Spiro{bicyclo[4.2.0]octa-1,3,5-triene-7,2′-[1,3]-dioxolan}-8-one. Encyclopedia of Reagents for Organic Synthesis. Gary W. ...
Bicyclo and Aromatic Compounds Class 11 Notes , EduRev search giving you solved answers for the same. Stereoisomers - Compounds ... IUPAC accepted their common trivial names e.g., The document Naming Alicyclic, Spiro, Bicyclo and Aromatic Compounds Class 11 ... Naming Alicyclic Spiro Bicyclo And Aromatic Compounds, Pdf Nomenclature Of Regular Double Strand Ladder And Spiro, 2 5 Naming ... Nomenclature Of Organic Compounds Pdf Alkane Functional, The Correct Iupac Name Of The Spiro Compound Br Img Src, Pdf ...
4 indent ) 2,2,1-bicyclo 121 .. (2 indent ) Cyclopentyl in acid moiety (e.g., prostaglandins, etc.) ... 4 indent ) Epoxy compound, or metal, utilized 354 .. (2 indent ) Containing polycyclo ring system having alicyclic ring as one ... 1 indent ) Compounds having the group -C(=X)-X-nX-, wherein the Xs may be the same or diverse chalcogens, nX is a divalent ... 1 indent ) Peroxynitrate esters (i.e., compounds having the -O-O-N(=O)(=O) group bonded directly to carbon, which carbon may be ...
... about INDIUM COMPOUNDS. Search and download thousands of Swedish university dissertations. Full text. Free. ... 3. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics. University dissertation ... Search for dissertations about: indium compounds. Showing result 1 - 5 of 9 swedish dissertations containing the words indium ... Abstract : Volatile organic compounds (VOCs) in the indoor air have adverse effects on the dwellers residing in a building or a ...
Pino, J.A.; Marbot, R.; Bello, A., Volatile compounds of Psidium salutare (H.B.K.) Berg. fruit, J. Agric. Food Chem., 2002, 50 ... 7-Dimethyl-2-methylen-bicyclo(2,2,1)heptane; 7,7-Dimethyl-2-methylenebicyclo[2.2.1]heptane; Fenchene, Bicyclo[2.2.1]heptane,2- ... Helmig, D.; Klinger, L.F.; Guenther, A.; Vierling, L.; Geron, C.; Zimmerman, P., Biogenic volatile organic compound emissions ( ... Meynier, A.; Novelli, E.; Chissolinim, R.; Zanardi, E.; Gandemer, G., Volatile compounds of commercial Milano salami, Meat Sci. ...
Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof ... Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof ... Fluorine-containing organosilicon compound US5321108A (en) * 1993-02-12. 1994-06-14. Bausch & Lomb Incorporated. Fluorosilicone ... Fluorine-containing organosilicon compound US5623029A (en) 1992-04-14. 1997-04-22. Allergan. Reinforced compositions and lens ...
  • The main focus of this thesis concerns the diastereoselective synthesis of heterocyclic compounds using main group elements as Lewis acid catalysts. (dissertations.se)
  • Study on cyclization reactions of heterocyclic compounds bearing ethynyl and formyl groups in close proximity to each other. (vu.lt)
  • Heterocyclic compounds for producing dyes are classified in subclass C09B . (uspto.gov)
  • Fowden, L.: The Occurrence and Metabolism of Carbon-Halogen Compounds. (springer.com)
  • The present invention provides applications of a small molecular flavonoid compound in preparing a medication for sensitizing/synergizing tumor radiation. (patents.com)
  • Several methods exist for the laboratory synthesis of dimethyl fumarate, with reported methods alkene isomerization of dimethyl maleate , and Fischer esterification of fumaric acid Dimethyl fumarate is an ester and an α,β-unsaturated electrophilic compound which can quickly undergo Michael additions with nucleophiles. (wikipedia.org)
  • The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the. (patents.com)
  • Synthesis, structural and association studies of chiral supramolecular polycyclic tectones based on bicyclo[3.3.1]nonane framework. (vu.lt)
  • Carbonylation of Aromatic (Pseudo)Halides to Carboxylic Acid Derivatives The palladium-catalyzed carbonylation of aryl X compounds to give carboxylic acid derivatives is becoming a valuable tool in organic synthesis. (docme.ru)
  • WO 97/6168 forms prior art under Art 54(3) (4) EPC and discloses the use of bis-diazo compounds in the synthesis of diaza bicyclo compounds. (patent-de.com)
  • The rapid synthesis of bicyclo[ m . n .1]alkanone cores possessing quaternary carbon centers adjacent to a bridged ketone represents a significant synthetic challenge. (beilstein-journals.org)
  • Volatile organic compounds (VOCs) in the indoor air have adverse effects on the dwellers residing in a building or a vehicle. (dissertations.se)
  • Wine is an alcoholic solution with a high variety of dissolved substances such as sugars, acids, alcohols, phenolic compounds, nitrogen compounds, macromolecular materials, minerals, and a number of volatile organic compounds that have great influence on sensory and variety characteristics of wine. (hindawi.com)
  • Norbornane (also known as bicyclo[2.2.1]heptane) is an organic compound and a saturated hydrocarbon with chemical formula C7H12. (wikipedia.org)
  • As aroma compounds are intrinsically volatile substances, most of the compounds should be determined by gas chromatography with the exception for thermolabile substances. (hindawi.com)
  • The bicyclo[3.3.1]nonane system adopts a boat-chair conformation. (eurekamag.com)
  • Overall, the invention provides the chemistry for the compounds and for the processes to prepare compounds derived from 1,5-diazacyclooctanes. (patents.com)
  • To name bicyclic compounds based on the International Union of Pure and Applied Chemistry (IUPAC) system of nomenclature, start with the term "bicyclo. (reference.com)
  • Lithium Phenylethynolate and Its Reaction with Carbony1 Compounds to Give p-Lactones By Ulrich Schollkopf and lnga Hoppe'] While enolates ( I ) have numbered among the most important reagents of organic chemistry for more than a century, ynolates (2) have hitherto remained unknown although their chemistry should certainly be no less interesting than that of the former class of compounds. (docme.ru)
  • Both types of target compounds were found to be suitable substrates for click reactions, and thus they are promising building blocks for medicinal, combinatorial and bioconjugate chemistry. (enamine.net)
  • Krebs, H.C.: Recent Developments in the Field of Marine Natural Products with Emphasis on Biologically Active Compounds. (springer.com)
  • It is a crystalline compound with a melting point of 88 °C. The carbon skeleton is derived from cyclohexane ring with a methylene bridge in the 1,4- position, and is a bridged bicyclic compound. (wikipedia.org)
  • The compound is a prototype of a class of strained bicyclic hydrocarbons. (wikipedia.org)
  • Bicyclo[1.1.1]pentane is an organic compound, the simplest member of the bicyclic bridged compounds family. (wikipedia.org)
  • The standard enthalpies of formation of bicyclic compounds. (nist.gov)
  • How do you name bicyclic compounds? (reference.com)
  • After 1981 researchers all over the world have focused on marine-derived Phoma for their bioactive compounds. (springer.com)
  • In addition, this review summarizes the novel bioactive compounds derived from marine Phoma and their biological activities. (springer.com)
  • Study for bioactive compounds in leaves yielded heneicosanoic acid (25.22), bicyclo [4.1.0] hepta-2, 4-dien (27.41), octadecanoic acid (CAS), stearic acid (31.19) and octadeca-9, 12-dienoic acid (32.02). (stuartxchange.com)
  • Nonaromatic compounds are hydrocarbon compounds that do not have a conjugate ring system, such as naphthalene, benzene or imidazole. (reference.com)
  • The 2D-GCxGC/TOFMS results showed that various types of hydrocarbon compounds (aliphatics, aromatics, cyclics olefins, and phenanthrene) were available in the liquid hydrocarbon fuel. (rsc.org)
  • Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds. (docme.ru)
  • DOI: 10.1002/anie.200900013 Palladium Catalysis Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds Anne Brennfhrer, Helfried Neumann, and Matthias Beller* Keywords: aryl halides · carbon monoxide · carbonylation · homogeneous catalysis · palladium Dedicated to Professor Armin de Meijere on the occasion of his 70th birthday Angewandte Chemie 4114 www.angewandte.org 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew. (docme.ru)
  • 1] This Review summarizes the recent work in the area of palladium-catalyzed carbonylation reactions of aryl halides and related compounds. (docme.ru)
  • In particular, coupling reactions of aryl-X compounds to give carboxylic acid derivatives, aldehydes, and ketones are described. (docme.ru)
  • Syntheses of bicyclo[1.1.1]pentane-derived azides and terminal alkynes - interesting substrates for click reactions - are described. (enamine.net)
  • Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. (sumobrain.com)
  • said compound is unsubstituted or substituted with a halo, alkyl, alkoxy, or combinations thereof. (google.com.au)
  • The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. (patents.com)
  • The preparation of bicyclo[1.1.1]pentyl-substituted alkynes relies on a Seyferth-Gilbert homologation with dimethyl 1-diazo-2-oxopropylphosphonate (Ohira-Bestmann reagent). (enamine.net)
  • With this reaction, compounds with bicyclo skeletons can be synthesized, e.g. a diester with a norbornene (bicyclo[2.2.1]heptene) skeleton from dimethyl fumarate and cyclopentadiene. (wikipedia.org)
  • 2-exo-Amino-6-endo-(methylthio)bicyclo[2.2.1]heptane-2-endo-carboxylic acid (lc) was synthesized by amination of the lithium enolate of methyl 6-endo-(methylthio)bicyclo[2.2.1]heptane-2-ercdo-carboxylate with 0-(mesitylenesulfonyl)hydroxylamine followed by hydrolysis. (elsevier.com)
  • The structure is compared both with 6-exo-(methylthio)bicyclo[2.2.1]heptane-2-endo-carboxylic acid (3) and the HBr salt of 2-exo-aminobicyclo[2.2.1]heptane-2-endo-carboxylic acid (2). (elsevier.com)
  • HS-SPME shows a much higher sensitivity to volatile aromatic compounds and semivolatile than other conventional headspace techniques [ 3 ]. (hindawi.com)
  • Therefore, compounds with molecules containing one or more of a non-aromatic rings are collectively categorized as nonaromatic compounds. (reference.com)
  • A seven-membered aromatic ring compound. (bireme.br)
  • Engvild, K.C.: Chlorine-Containing Natural Compounds in Higher Plants. (springer.com)
  • Amadis Chemical Co., Ltd. provides Pharmaceutical Intermediates, Active Pharmaceutical Ingredients (APIs) and Natural Compounds. (chemicalregister.com)
  • Liquid hydrocarbons as fuel were found to be appropriate for use in petrol and diesel engines and they were found to be a good source of organic compounds/petrochemicals. (rsc.org)
  • As a α,β-unsaturated electrophilic compound, dimethyl fumarate is rapidly attacked by the detoxifying agent glutathione (GSH) in a Michael addition reaction. (wikipedia.org)
  • A phase transfer catalyst facilitates the reaction in a heterogeneous system between general organic compounds that are soluble in organic solvents and com. (reference.com)
  • Bringing together the research and methods of leading scientists in the fluorine field, Efficient Preparations of Fluorine Compounds is the definitive manual to creating, and understanding the reaction mechanisms integral to a wide variety of fluorine compounds. (wiley.com)
  • In order to solve this issue, we assumed that bicyclo[3.3.1]nonenone scaffolds can be directly obtained through an intermolecular Diels-Alder reaction/Au(I)-catalyzed 6- endo-dig carbocyclization ( Scheme 3 ). (beilstein-journals.org)
  • There are prepared reaction products of a. 4,4-bis-(hydroxymethyl)-cyclohexene compounds of the formula ##EQU1## where R1, R2 and R4 are the same or different and are hydrogen, methyl or phenyl and there is also present either (1) X as the bridging member methylene or ethylene or (2) X is absent and. (google.ca)
  • A compound of formula (I). The present invention relates to therapeutically active .beta. (patents.com)
  • The invention relates to HIV protease inhibitors wherein the compounds have a 2,4-dihydroxy isostere wherein the hydroxyl group in the 2-position is further substituted to create a tertiary alcohol. (sumobrain.com)
  • In particular, this invention pertains to the method of improving sensitivity in laser induced thermal imaging using diazo compounds. (patent-de.com)
  • In accordance with the present invention, the sensitivity of laser induced thermal imaging systems can be increased by using diazo compounds that contain at least one electron withdrawing functional group adjacent the diazo substituent capable of stabilizing the diazo substituent (i.e., the =N + =N - substituent). (patent-de.com)
  • The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. (freepatentsonline.com)
  • A process for producing compounds represented by general formulae (III) and (IV), which are useful as intermediates for the production of amino acid derivatives which have a renin inhibitory activity and are useful as a hypotensive, ster. (sumobrain.com)
  • To study the structure activity relationship (SAR) on the cytotoxic activity and probe the structural requirement for the potent antitumor activity, a series of novel diazaspiro bicyclo hydantoin derivatives were designed and synthesized. (springer.com)
  • The oil is then distilled under reduced pressure (74-79°C at 0.06 mm) to yield analytically pure bicyclo[3.3.0]octane-2,6-dione , 4 ( 6.4-7.1 g , 52-58% ) as a white crystalline solid, mp 45-46°C (lit. (orgsyn.org)
  • 2. A liquid-crystalline compound according to claim 1, wherein R.sup.1 is a straight-chain alkyl radical having from 1 to 7 carbon atoms or an alkenyl radical having from 2 to 10 carbon atoms. (patentgenius.com)
  • 4. A liquid-crystalline compound according to claim 1, wherein c=1. (patentgenius.com)
  • 6. A liquid-crystalline medium comprising at least two mesogenic compounds, wherein at least one of said compounds is a compound according to claim 1. (patentgenius.com)
  • Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same. (sumobrain.com)
  • The low-molecular weight organic compounds (LMWOC) of the extracts were defined by methods of GC/MS with the help of Shimadzu GC/MS (QP-5050А, Shimadzu, Japan) equipped with the software Class 5000 and chromato-mass spectrometer TRACE DSQ II (Thermo Electron Corporation) with quadrupole mass analyser. (ijpsonline.com)
  • Preparations for medical, dental, or toilet purposes or methods of using compounds for the same purposes are classified in subclass A61K . (uspto.gov)
  • N.B.: when the compound per se is novel, the medicinal preparation and/or methods of use are not classified in A61K 31/00 in CPC). (uspto.gov)
  • Pharmaceutical compositions containing these compounds, methods of using these. (patents.com)
  • Cover compounds containing one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system, with or without other non-condensed hetero rings. (uspto.gov)
  • Monospiro compounds consisting of only two alicyclic rings as components are named by placing "spiro" before the name of the normal acyclic hydrocarbon of the same total number of carbon atoms. (itb-entertainment.com)
  • Specifically, infrared light which has been generated by a laser is first absorbed by a radiation absorber (e.g., an infrared absorbing material such as an infrared dye, black alumina, or carbon black) and then converted to heat to decompose the energetic compound. (patent-de.com)
  • Heterocycles incorporating elements other than C, H, halogen, N, O, S, Se or Te are classified in subclass C07F , but only if the metal-containing compound has a metal carbon bond or if the metal is attached to at least two different ligands. (uspto.gov)
  • The compounds are represented by compounds of formula (1.0) and their pharmaceutically acceptable salts and solvates. (sumobrain.com)
  • Examples of such energetic compounds include diazonium salts as well as compounds containing azo, azido, nitrato, and nitramino groups, such as nitrocellulose, polyvinyl nitrates, and the like. (patent-de.com)
  • The only exception to this requirement is that the compounds may contain metal atoms, but only as the cations of heterocyclic organic acid salts, alcoholates, phenolates or mercaptides, or as chelating atoms, e.g. in porphyrins. (uspto.gov)
  • Salts, chelates, alcoholates (except Ti/Zr), phenates involving a single ligand are classified as the parent compound (metal containing porphyrin C07D 487/22 ). (uspto.gov)
  • Stereoisomers - Compounds that have the same molecular formula and the same connectivity, but different arrangement of the atoms in 3-dimensional space. (itb-entertainment.com)
  • Phenolic compounds profile yielded ellagic acid (4.13 min), catechol (3.59 min), gallic acid (4.12 min) and catechin (7.41 min). (stuartxchange.com)
  • Genetic parameters are established prognostic factors in chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy, but are less well studied with novel compounds. (cdc.gov)
  • The antiproliferative effect of these compounds were determined against human leukemia, K562 (chronic myelogenous leukemia) and CEM (T-cell leukemia) cells using trypan blue and MTT assay, and the SAR associated with the position of N-terminal substituents in diazaspiro bicyclo hydantoin have also been discussed. (springer.com)
  • Selection of sampling techniques, sample preparation, determinants separation, detection, and quantification, will be essential and crucial for the proper chemical characterization of aroma-related compounds. (hindawi.com)
  • Biocidal, pest attractant, or plant growth regulatory activity of chemical compounds or preparations is further classified in subclass A01P (this subclass does only exist in IPC).Therapeutic activity of chemical compounds is further classified in subclass A61P . (uspto.gov)
  • Natural chlorine-, bromine-, iodine-, and fluorine-containing organic chemical compounds are abundant on our planet. (springer.com)
  • Resembling a spirit from a chemical netherworld, fluorine is highly reactive, difficult to handle, yet very versatile as a reagent-with the power to form compounds with almost any other element. (wiley.com)
  • The only chemical resource of its kind, Efficient Preparations of Fluorine Compounds -from its first experiment to its last-is a unique window into the centuries old science of fluorine and the limitless universe of fluorine-based compounds. (wiley.com)
  • Methodology: Air-dried and pulverized leaves were hydrodistilled in a Clevenger-type apparatus to obtained pale yellow volatile oil whose chemical constituents was analyzed by GC and GC/MS. Results: A total of sixty compounds were identified, amounting to 98.9%of the total oil contents. (bvsalud.org)
  • The position and number of substituents in benzyl group attached to N− 8 of diazaspiro bicyclo hydantoin nucleus interacted selectively with specific targets leading to the difference of biochemical and pharmacological effects. (springer.com)
  • There were 71 low molecular weight organic compounds observed, two of which remained unidentified. (ijpsonline.com)
  • Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. (sumobrain.com)
  • Compounds having unique antiviral properties found in mushroom mycelium and their analogs are extracted, concentrated, isolated or manufactured to create. (patents.com)
  • It has been observed that these compounds displayed strong, moderate and weak cytotoxic activities. (springer.com)
  • Interestingly, compounds having electron withdrawing groups at third and fourth position of the phenyl ring displayed selectively cytotoxic activities to both the cell lines tested with IC 50 value lower than 50 μM. (springer.com)
  • Preparation of such compounds, including purification, separation, stabilisation or use of additives, unless a separate place is provided elsewhere in the classification scheme. (uspto.gov)
  • Chemoenzymatic Large Scale Preparation of Homochiral Bicyclo [3.2.0. (elsevier.com)
  • We do not sell or distribute the pharmaceutical compounds written about in this database. (springer.com)
  • Comprising 20% of pharmaceutical products and 30% of agrochemical compounds, as well as playing a key role in electric cars, electronic devices, and space technology, compounds containing fluorine have grown in importance across the globe. (wiley.com)
  • Nonaromatic compounds do not have a loop for pi electron. (reference.com)
  • Hydrazone compounds which modulate cannabinoid receptors are presented. (patents.com)
  • In class C07 , the last place priority rule is used, i.e. in the absence of an indication to the contrary, a compound is classified in the last appropriate subclass. (uspto.gov)
  • Similarly, compounds containing saccharide radicals are classified in subclass C07H , and heterocyclic steroids are classified in subclass C07J . (uspto.gov)
  • This subclass is a structure-oriented entry for the compounds themselves and does not cover the application or use of the compounds under the subclass definition. (uspto.gov)
  • Prior to the analysis organotin compounds were derivatized using sodium tetraethylborate as derivatization reagent. (vu.lt)