Compounds with 1,2-diphenylethane. They are structurally like reduced STILBENES.
A plant division. They are simple plants that lack vascular tissue and possess rudimentary rootlike organs (rhizoids). Like MOSSES, liverworts have alternation of generations between haploid gamete-bearing forms (gametophytes) and diploid spore-bearing forms (sporophytes).
An oil-resistant synthetic rubber made by the polymerization of chloroprene.
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Governmental levies on property, inheritance, gifts, etc.
The charge levied on the consumer for drugs or therapy prescribed under written order of a physician or other health professional.
Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.
Traditional Arabic methods used in medicine in the ARAB WORLD.
A superfamily of parasitic nematodes which were formerly considered a part of TRICHOSTRONGYLOIDEA. It includes the following genera: Heligmosomum, NEMATOSPIROIDES, and NIPPOSTRONGYLUS. The hosts are rodents.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
Seedless nonflowering plants of the class Filicinae. They reproduce by spores that appear as dots on the underside of feathery fronds. In earlier classifications the Pteridophyta included the club mosses, horsetails, ferns, and various fossil groups. In more recent classifications, pteridophytes and spermatophytes (seed-bearing plants) are classified in the Subkingdom Tracheobionta (also known as Tracheophyta).
A division of the plant kingdom. Bryophyta contains the subdivision, Musci, which contains the classes: Andreaeopsida, BRYOPSIDA, and SPHAGNOPSIDA.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Those individuals engaged in research.
Financial support of research activities.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
A plant genus of the family FABACEAE. Members contain isoacteoside, luteolin, indole-3-carboxylic acid.
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.
The single family of PRIMATES in the infraorder TARSII, suborder HAPLORHINI. It is comprised of one genus, Tarsius, that inhabits southern Sumatra, Borneo, Sulawesi, and the Philippines.
A plant genus of the family CELASTRACEAE. Members contain friedelane-type TRITERPENES and SESQUITERPENES, EUDESMANE.
The endogenous peptides with opiate-like activity. The three major classes currently recognized are the ENKEPHALINS, the DYNORPHINS, and the ENDORPHINS. Each of these families derives from different precursors, proenkephalin, prodynorphin, and PRO-OPIOMELANOCORTIN, respectively. There are also at least three classes of OPIOID RECEPTORS, but the peptide families do not map to the receptors in a simple way.
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.
Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Infections with nematodes of the genus DIPETALONEMA.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Organic compounds that contain silicon as an integral part of the molecule.
A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
Organic compounds that contain 1,2-diphenylethylene as a functional group.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)

Erianin induces apoptosis in human leukemia HL-60 cells. (1/44)

AIM: To investigate the effect of erianin on human HL-60 cell line and explore its mechanism of apoptosis in vitro. METHODS: Inhibition of proliferation was measured with colorimetric MTT assay. The morphologic changes were observed by fluorescence and electron microscopes. DNA fragmentation was visualized by agarose gel electrophoresis, and the DNA degradation was determined by flow cytometry. Immunohistochemical analysis was used to identify the expression of bcl-2 and bax genes. RESULTS: The growth of human HL-60 cells was significantly inhibited by erianin 20-81.9 nmol/L during 72 h treatment (P < 0.01). The IC50 value was 38 nmol/L after a 24-h exposure to erianin, while that of vincristine, the positive control, was 101 nmol/L. The typical morphologic changes were observed and the nuclear DNA fragmentation exhibited "ladder" pattern. The cell cycle of HL-60 cells was arrested in G2/M phase, and expression of bcl-2 gene was decreased while that of bax was increased. CONCLUSION: Erianin showed potent inhibitory activity on the proliferation of HL-60 cells. The inhibition might be relative to the apoptosis induced by erianin and the altered expression of bcl-2 and bax genes in HL-60 cells.  (+info)

The biology of the combretastatins as tumour vascular targeting agents. (2/44)

The tumour vasculature is an attractive target for therapy. Combretastatin A-4 (CA-4) and A-1 (CA-1) are tubulin binding agents, structurally related to colchicine, which induce vascular-mediated tumour necrosis in animal models. CA-1 and CA-4 were isolated from the African bush willow, Combretum caffrum, and several synthetic analogues are also now available, such as the Aventis Pharma compound, AVE8062. More soluble, phosphated, forms of CA-4 (CA-4-P) and CA-1 (CA-1-P) are commonly used for in vitro and in vivo studies. These are cleaved to the natural forms by endogenous phosphatases and are taken up into cells. The lead compound, CA-4-P, is currently in clinical trial as a tumour vascular targeting agent. In animal models, CA-4-P causes a prolonged and extensive shut-down of blood flow in established tumour blood vessels, with much less effect in normal tissues. This paper reviews the current understanding of the mechanism of action of the combretastatins and their therapeutic potential.  (+info)

New bibenzyl cannabinoid from the New Zealand liverwort Radula marginata. (3/44)

The ether extract of the New Zealand liverwort Radula marginata afforded a new cannabinoid type bibenzyl compound named perrottetinenic acid, and two new bibenzyls, together with a known cannabinoid, perrottetinene. Their structures were established by two dimensional (2D) NMR spectral data. The structure of perrottetinenic acid was a similar to that of Delta(1)-tetrahydrocannabinol, a known hallucinogen. Cannabinoid type bibenzyls have been isolated from liverwort Radula perrottetii, though have not previously been reported from the liverwort R. marginata.  (+info)

Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. (4/44)

PURPOSE: A phase I trial was performed with combretastatin A4 phosphate (CA4P), a novel tubulin-binding agent that has been shown to rapidly reduce blood flow in animal tumors. PATIENTS AND METHODS: The drug was delivered by a 10-minute weekly infusion for 3 weeks followed by a week gap, with intrapatient dose escalation. Dose escalation was accomplished by doubling until grade 2 toxicity was seen. The starting dose was 5 mg/m2. RESULTS: Thirty-four patients received 167 infusions. CA4P was rapidly converted to the active combretastatin A4 (CA4), which was further metabolized to the glucuronide. CA4 area under the curve (AUC) increased from 0.169 at 5 mg/m2 to 3.29 micromol * h/L at 114 mg/m2. The mean CA4 AUC in eight patients at 68 mg/m2 was 2.33 micromol * h/L compared with 5.8 micromol * h/L at 25 mg/kg (the lowest effective dose) in the mouse. The only toxicity that possibly was related to the drug dose up to 40 mg/m2 was tumor pain. Dose-limiting toxicity was reversible ataxia at 114 mg/m2, vasovagal syncope and motor neuropathy at 88 mg/m2, and fatal ischemia in previously irradiated bowel at 52 mg/m2. Other drug-related grade 2 or higher toxicities seen in more than one patient were pain, lymphopenia, fatigue, anemia, diarrhea, hypertension, hypotension, vomiting, visual disturbance, and dyspnea. One patient at 68 mg/m2 had improvement in liver metastases of adrenocortical carcinoma. CONCLUSION: CA4P was well tolerated in 14 of 16 patients at 52 or 68 mg/m2; these are doses at which tumor blood flow reduction has been recorded.  (+info)

Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate. (5/44)

PURPOSE: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical trials, but recent preclinical studies have shown that CA1P displays a greater antitumor effect than the combretastatin A4 (CA4) analog at equal doses. The aim of this study, therefore, is to compare pharmacokinetics and metabolism of the two compounds to determine whether pharmacokinetics plays a role in their differential activity. EXPERIMENTAL DESIGN: NMRI mice bearing MAC29 tumors received injection with either CA4P or CA1P at a therapeutic dose of 150 mg x kg(-1), and profiles of both compounds and their metabolites analyzed by a sensitive and specific liquid chromatography/mass spectroscopy method. RESULTS: The metabolic profile of both compounds is complex, with up to 14 metabolites being detected for combretastatin A1 (CA1) in the plasma. Many of these metabolites have been identified by liquid chromatography/mass spectroscopy. Initial studies, however, focused on the active components CA4 and CA1, where plasma and tumor areas under the curve were 18.4 and 60.1 microg x h x ml(-1) for CA4, and 10.4 and 13.1 microg x h x ml(-1) for CA1, respectively. In vitro metabolic comparisons of the two compounds strongly suggest that CA1 is metabolized to a more reactive species than the CA4. CONCLUSIONS: Although in vitro studies suggest that variable rates of tumor-specific prodrug dephosphorylation may explain these differences in pharmacokinetics profiles, the improved antitumor activity and altered pharmacokinetic profile of CA1 may be due to the formation of a more reactive metabolite.  (+info)

Erianin induces a JNK/SAPK-dependent metabolic inhibition in human umbilical vein endothelial cells. (6/44)

BACKGROUND: Erianin is a natural product derived from Dendrobium chrysotoxum, with promising antitumor activity. MATERIALS AND METHODS: To evaluate the metabolic effect of erianin, a cytosensor assay for acidification rate, MTT assay, measurement of lactate, glucose and ATP were performed in human umbilical vein endothelial cells (HUVECs) exposed to 1-100 nM erianin. JNK/SAPK activity was detected by Western blot. RESULTS: Twelve- or 24- hour incubation with erianin induced a dose-dependent metabolic inhibition, as indicated by reduced acidification rate and cell viability, with an endothelium-selectivity. Erianin caused decreases in lactate production, glucose consumption and intracellular ATP level. Pretreatment with the JNK/SAPK inhibitor SP600125 significantly abolished these inhibitory responses, and especially restored the erianin-induced decreases in ATP and the erianin-induced phosphorylation of JNK/SAPK with dose- and time- dependence. CONCLUSION: Erianin inhibited endothelial metabolism in a JNK/SAPK-dependent manner. This mechanism may be involved in the potential antitumnor and antiangiogenic actions of erianin.  (+info)

A dual-color fluorescence imaging-based system for the dissection of antiangiogenic and chemotherapeutic activity of molecules. (7/44)

We have developed a simple yet sensitive dual color fluorescence-based technique for dissecting the tumor-neovascularization relationship and evaluated the susceptibility of each component to therapeutic interventions. Green fluorescent protein (GFP)-expressing melanoma cells were cocultured with endothelial cells on different three-dimensional (3-D) matrices and exposed to multiple growth factors and molecules with established anti-angiogenic or anticancer activities. Cells were fixed and stained with propidium iodide, imaged using a confocal microscope, and stereologically analyzed. Three-dimensionality of the system was tested by depth-coding and pseudocolor 3-D reconstruction in the z-axis. Selective ablation of the tumor cells was affected by the anthracycline antibiotic doxorubicin. Treatment with vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) promoted the neovascular responses on matrigel and collagen-1 matrices. VEGF-induced angiogenesis was inhibited after treatment with combretastatin and thalidomide. In contrast, HGF exerted a protective effect against these anti-angiogenics in a matrigel matrix. However, this effect was lost when the matrix was substituted with collagen, suggesting that the extracellular matrix impinges on cellular function, possibly through an Akt-mediated mechanism. The VEGF-receptor antagonist PTK787 also selectively ablated the VEGF-induced angiogenic effect without inhibiting the HGF-induced response, demonstrating the sensitivity of the system to detect modulation of distinct signal cascades. The current model encompasses the possibility of studying tumor-angiogenesis-matrix interaction on the same platform, expanding the rapid screening of novel molecules in a simulated clinicopathological setting.  (+info)

Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. (8/44)

In the continuing search for effective treatments for cancer, the emerging model is the combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood vessel growth. However, the implementation of this strategy has faced two major obstacles. First, the long-term shutdown of tumour blood vessels by the anti-angiogenesis agent can prevent the tumour from receiving a therapeutic concentration of the chemotherapy agent. Second, inhibiting blood supply drives the intra-tumoural accumulation of hypoxia-inducible factor-1alpha (HIF1-alpha); overexpression of HIF1-alpha is correlated with increased tumour invasiveness and resistance to chemotherapy. Here we report the disease-driven engineering of a drug delivery system, a 'nanocell', which overcomes these barriers unique to solid tumours. The nanocell comprises a nuclear nanoparticle within an extranuclear pegylated-lipid envelope, and is preferentially taken up by the tumour. The nanocell enables a temporal release of two drugs: the outer envelope first releases an anti-angiogenesis agent, causing a vascular shutdown; the inner nanoparticle, which is trapped inside the tumour, then releases a chemotherapy agent. This focal release within a tumour results in improved therapeutic index with reduced toxicity. The technology can be extended to additional agents, so as to target multiple signalling pathways or distinct tumour compartments, enabling the model of an 'integrative' approach in cancer therapy.  (+info)

0060] Pharmaceutically acceptable prodrugs of the compounds of formula (I), (II) or (III) are derivatives which have chemically or metabolically cleavable groups and become, by solvolysis or under physiological conditions, the compounds of the present invention which are pharmaceutically active in vivo. Prodrugs of the compounds of formula (I), (II) or (III) may be formed in a conventional manner with a functional group of the compounds such as with an amino or a hydroxyl group. The prodrug derivative form often offers advantages of solubility, tissue compatibility or delayed release in a mammalian organism (see, Bundgaard, H., Design of Prodrugs, pp. 7-9, 21-24, Elsevier, Amsterdam 1985). When a compound employed in the present invention has a hydroxyl group, an acyloxy derivative prepared by reacting the hydroxyl group with a suitable acylhalide or a suitable acid anhydride is exemplified as a prodrug. An especially preferred acyloxy derivative as a prodrug is --OC(═O)--CH3, ...
Zybrestat (combretastatin A4 phosphate) is a prodrug that is converted to combretastatin inside the endothelial cells that line blood vessels. Combretastatin has a dual-mode of action, targeting both VE-cadherin, a junction protein that is important for endothelial cell survival, and the associated beta-catenin/AKT signalling pathway.. Once activated within the endothelial cell, it causes rapid collapse and necrosis of the tumours vascular structure.. As a reversible tubulin depolymerizing agent, combretastatin also causes tumour-associated endothelial cells to change from a flat to a round shape. This has the effect of plugging the blood vessels so depriving the tumour of the oxygen and nutrients it needs to survive.. Because the endothelial cells of tumours are immature they are much more sensitive to the effects of combretastatin than the endothelial cells of normal tissue.. ...
Members of the combretastatin family possess varying ability to cause vascular disruption in tumors. Combretastatin binds to the β-subunit of tubulin at what is called the colchicine site, referring to the previously discovered vascular disrupting agent colchicine. Inhibition of tubulin polymerization prevents cancer cells from producing microtubules. Microtubules are essential to cytoskeleton production, intercellular movement, cell movement, and formation of the mitotic spindle used in chromosome segregation and cellular division. The anti-cancer activity from this action results from a change in shape in vasculature endothelial cells. Endothelial cells treated with combretastatin rapidly balloon in shape causing a variety of effects which result in necrosis of the tumor core. The tumor edge is supported by normal vasculature and remains, for the most part, unaffected. As a result it is likely that any therapeutic use will involve a combination of drugs or treatment options. ...
About ZYBRESTAT (fosbretabulin) ZYBRESTAT is being evaluated in a Phase 2 study of patients with NSCLC and other clinical trials. OXiGENE believes that ZYBRESTAT is poised to become an important product in a novel class of small-molecule drug candidates called vascular disrupting agents (VDAs). Through interaction with vascular endothelial cell cytoskeletal proteins, ZYBRESTAT selectively targets and collapses tumor vasculature, thereby depriving the tumor of oxygen and nutrients, causing death of tumor cells. In clinical trials in solid tumors, ZYBRESTAT has demonstrated potent and selective activity against tumor vasculature, as well as clinical activity against ATC, ovarian cancer and various other solid tumors. About OXiGENE OXiGENE is a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases. The Companys major focus is developing vascular disrupting agents (VDAs) that selectively disrupt abnormal blood vessels associated with solid tumor ...
Members of OXiGENEs management team will review first quarter results via a webcast and conference call today at 2:00 p.m. EDT (11:00 a.m. PDT). To listen to a live or an archived version of the audio webcast, please log on to the Companys website, www.oxigene.com. Under the Investor Center tab, select the link to Presentations & Conference Calls.. OXiGENEs earnings conference call can also be heard live by dialing (888) 208-1507 in the United States and Canada, and (913) 312-0402 for international callers, five minutes prior to the beginning of the call. A replay will be available starting at 5:00 p.m. EDT (2:00 p.m. PDT) on August 4, 2008 and ending at 5:00 p.m. EDT (2:00 p.m. PDT) on Monday, August 11, 2008. To access the replay, please dial (888) 203-1112 if calling from the United States or Canada, or (719) 457-0820 from international locations. Please refer to replay pass code 6113741. About ZYBRESTAT (fosbretabulin) ZYBRESTAT is currently being evaluated in a pivotal registration ...
TY - CHAP. T1 - Anthracycline, Trastuzumab, and Cardiovascular Toxicity. AU - Cochran, T. R.. AU - Franco, V. I.. AU - Scully, R.. AU - Lipshultz, S. E.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - In cancer treatment, the pervasive late effects of radiation and chemotherapy limit their utility, especially in children, in whom treatment often leads to lifelong morbidity and excess mortality. Advances in understanding the molecular pathways related to tumorigenesis have led to the development of targeted therapies, but recurrent late effects, as in the case of trastuzumab, and unexpectedly high rates of cardiotoxicity highlight gaps in our understanding of drug pathways and the mechanisms of treatment toxicity. Here, we review the mechanisms of anthracycline activity in tumor and cardiac cells, as well as the clinical manifestations and their associated cardiotoxicity, prevention strategies, and monitoring recommendations. We also describe the cardiac effects of trastuzumab with specific attention to its ...
Re: [dts] [PATCH V2]tests/shutdown_api: fix cant create vf 2020-03-20 8:37 [dts] [PATCH V2]tests/shutdown_api: fix cant create vf Zeng Xiaoxiao 2020-03-20 9:02 ` Zeng, XiaoxiaoX @ 2020-03-24 6:51 ` Tu, Lijuan 1 sibling, 0 replies; 4+ messages in thread From: Tu, Lijuan @ 2020-03-24 6:51 UTC (permalink / raw) To: Zeng, XiaoxiaoX, dts; +Cc: Zeng, XiaoxiaoX Applied, thanks , -----Original Message----- , From: dts [mailto:[email protected]] On Behalf Of Zeng Xiaoxiao , Sent: Friday, March 20, 2020 4:38 PM , To: [email protected] , Cc: Zeng, XiaoxiaoX ,[email protected], , Subject: [dts] [PATCH V2]tests/shutdown_api: fix cant create vf , , Signed-off-by: Zeng Xiaoxiao ,[email protected], , --- , tests/TestSuite_shutdown_api.py , 6 +++++- , 1 file changed, 5 insertions(+), 1 deletion(-) , , diff --git a/tests/TestSuite_shutdown_api.py , b/tests/TestSuite_shutdown_api.py index 11d451b..8699e79 100644 , --- a/tests/TestSuite_shutdown_api.py , +++ b/tests/TestSuite_shutdown_api.py , @@ ...
From the stem bark of Salacia chinensis L. collected in Vietnam, eight triterpenoids were isolated, including one new natural product.Phytochemical studies has shown that the liverwort Pallavicinia lyellii may have two chemotypes: one chemotype can produce bis bibenzyls (type I a?? collected in Singapore), while the other one does not have that capability (type II a?? collected in Vietnam). This is the first report of the isolation of bis bibenzyls in the family Pallaviciniaceae. Both chemotypes, however, biosynthesized a number of complex modified labdane diterpenoids. Type II P. lyellii can produce Diels-Alder cycloaddition type dimeric diterpenoids. This is also the first report of 2-oxygenated labdane diterpenoid in liverworts.Bioassays screening for nociceptin receptor (NOP) ligand revealed that the crude extract of the Vietnamese P. lyellii has higher binding affinity to NOP than the endogenous ligand OFQ/N. Further investigation is needed in order to identify the potential NOP ligand from ...
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue.
Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery systems. However, a major drawback remains its toxicity to healthy tissue and the development of multi-drug resistance during prolonged treatment. This is why in our work we aimed to improve DOX delivery and reduce the toxicity by chemical conjugation with a new nanoplatform based on polymalic acid. For delivery into recipient cancer cells, DOX was conjugated via pH-sensitive hydrazone linkage along with polyethylene glycol (PEG) to a biodegradable, non-toxic and non-immunogenic nanoconjugate platform: poly(β-L-malic acid) (PMLA). DOX-nanoconjugates were found stable under physiological conditions and shown to successfully inhibit in vitro cancer cell growth of several invasive breast carcinoma cell lines such as MDA-MB-231 and MDA-MB- 468 and of primary glioma cell lines such as U87MG and U251.
Presumably, progression of developmental retinal vascular disorders is mainly driven by persistent ischemia/hypoxia. An investigation into vision-threatening retinal ischemia remains important. Our aim was to evaluate, in relation to retinal ischemia, protective effects and mechanisms of Dendrobium nobile Lindley (DNL) and its bibenzyl component moscatilin. The therapeutic mechanisms included evaluations of levels of placental growth factor (PLGF) and Norrie disease protein (NDP). An oxygen glucose deprivation (OGD) model involved cells cultured in DMEM containing 1% O2, 94% N2 and 0 g/L glucose. High intraocular pressure (HIOP)-induced retinal ischemia was created by increasing IOP to 120 mmHg for 60 min in Wistar rats. The methods included electroretinogram (ERG), histopathology, MTT assay and biochemistry. When compared with cells cultured in DMEM containing DMSO (DMSO+DMEM), cells subjected to OGD and pre-administrated with DMSO (DMSO+OGD) showed a significant reduction in the cell viability and NDP
Show more ,Combretastatin A-4 and isocombretastatin A-4 derivatives having thiophenes or benzo[b]thiophenes instead of the B ring were prepared and evaluated for their in cellulo tubulin polymerization inhibition (TPI) and antiproliferative activities. The presence of the benzo[b]thiophene ring proved to have a crucial effect as most of the thiophene derivatives, except those having one methoxy group, were inactive to inhibit tubulin polymerization into microtubules. The influence of the attachment position was also studied: benzo[b]thiophenes having iso or cis 3,4,5-trimethoxystyrenes at position 2 were 12-30-fold more active than the 3-regioisomers for the TPI activity. Some of the novel designed compounds exhibited interesting anti-proliferative effects on two different cell lines.Show less , ...
TY - JOUR. T1 - Cardiovascular toxicities associated with immune checkpoint inhibitors. AU - Hu, Jiun Ruey. AU - Florido, Roberta. AU - Lipson, Evan. AU - Naidoo, Jarushka. AU - Ardehali, Reza. AU - Tocchetti, Carlo G.. AU - Lyon, Alexander R.. AU - Padera, Robert F.. AU - Johnson, Douglas B.. AU - Moslehi, Javid. PY - 2019/4/15. Y1 - 2019/4/15. N2 - Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in case series but have been underappreciated due to their recent emergence, difficulties in diagnosis and non-specific clinical manifestations. ICIs are antibodies that block negative regulators of the T cell immune response, including cytotoxic T lymphocyte-associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and PD-1 ligand (PD-L1). While ICIs have introduced a significant mortality benefit in several cancer types, the augmented immune response has led to a range of immune-related toxicities, including cardiovascular toxicity. ...
Vincent L,Kermani P,Young LM,Cheng J,Zhang F,Shido K,Lam G,Bompais-Vincent H,Zhu Z,Hicklin DJ,Bohlen P,Chaplin DJ, et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest 2005; 115: 2992-3006 ...
and mean vessel diameter R. The pre- and posttreatment histogram shapes of R are in qualitative agreement with those obtained in our study supporting a common mechanism of action for the 2 tubulin-binding agents. The peak in the histogram for pretreatment R occurs at a slightly higher vessel size in our study, which may be attributed to scaling problems as addressed later, and while the increases in median and upper quartile of R in our study were not significant, they found significant reductions in percentiles at 60% and below. Our finding is also in agreement with intravital microscopy data on CA4P activity showing that reduction in venule number is largest for small venules (diameter , 10 μm), and that reduction in arteriolar diameter occurs (11). The distribution of R in the current study may reflect the combination of these vascular effects. The reduction in vessels with radii in the interval (≈20-30 μm) could reflect the reported reduction in small venules. As the number of vessels ...
J. E. Heavner, C. F. Dryden, V. Sanghani, G. Huemer, A. Bessire, J. M. Badgwell; Severe Hypoxia Enhances Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Lightly Anesthetized Pigs. Anesthesiology 1992;77(1):142-147. Download citation file:. ...
Binding agents with differential activity can be provided, whereby certain activities of a first part of the binding agent are reduced or prevented until binding to a target occurs. This is useful if the binding agent is intended to bind both an effector cell and a target to be destroyed, because the effector cell can be protected from significant cell damage that might otherwise occur (e.g. due to premature activation of complement and/or ADCC). Such binding agents are useful in the treatment of cancer, for example.
Dendrobium antennatum - Flowering size,, Pot-grown plant, Plant size ca. 30cm, Flower size ca. 4 - 5cm, Semishade to sunny, Moderately damp, Temperate, May - September, No rest period
Université de Liège - ULg , Département clinique des animaux de compagnie et des équidés , Département clinique des animaux de compagnie et des équidés ,] ...
Free Ampare Shutdown Manager Download,Ampare Shutdown Manager 1.2 is A tool lets you manage your computers shutdown, restart or logoff.
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A government shutdown Oct. 1 could stop some federal services, but tax payments will be due on their regular deadlines, including Oct. 15 extensions.
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The stilbenic compound (Z)-combretastatin A-4 (CA-4) has been described as a potent tubulin polymerization inhibitor. In vivo, CA-4 binds to tubulin and inhibits microtubule depolymerization, which results in morphological changes in proliferating endothelial cells. Combretastatin A-4 prodrug phosphate is a leading vascular disrupting agent and is currently being evaluated in multiple clinical trials as a treatment for solid tumors. The aim of this study was to identify and characterize the UDP-glucuronosyltransferase (UGT) isoforms involved in CA-4 glucuronidation by incubation with human liver microsomes and a panel of nine liver-expressed recombinant UGT Supersomes (1A1, 1A3, 1A4, 1A6, 1A9, 2B4, 2B7, 2B15, and 2B17). As we observed, the high rate of formation of CA-4 glucuronide (Vmax = 12.78 ± 0.29 nmol/min/mg protein) and the low Km (6.98 ± 0.65 μM) denoted that UGT1A9 was primarily responsible for the in vitro glucuronidation of CA-4. UGT1A6 was also a significant contributor to CA-4 ...
Natural antioxidants and plant-derived compounds provide a strong defense against cellular damage caused by free-radical induced oxidative stress [16, 17]. Free-radicals and various reactive oxygen species are produced during cellular metabolism in all living systems and are responsible for oxidative cellular damage in human beings. To reduce this damage, some sort of defense mechanism is needed, and indeed, several types of natural and artificial antioxidants are used to control oxidative stress. In particular, plant-derived compounds are a potent source of novel antioxidant activity [18]. Bibenzyl derivatives isolated from D. moniliforme were examined for their antioxidant capacity using DPPH free-radical scavenging assay [11, 13, 14], a popular tool because of its simplicity and high sensitivity. This assay works on the principle that any hydrogen donor is an antioxidant. Thus, a compounds antioxidant effect is proportional to the disappearance of DPPH radicals in test samples [19].. The ...
TY - JOUR. T1 - Cardiovascular toxicity of tyrosine kinase inhibitors. AU - Mouhayar, Elie. AU - Durand, Jean Bernard. AU - Cortes, Jorge. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Introduction: Small-molecule tyrosine kinase inhibitors (TKIs) have revolutionized the management of many malignancies. However, they also have been shown to be associated with a certain degree of cardiovascular side effects that are often reversible. Areas covered: As the number of new TKIs continues to grow, it is expected that clinicians will be facing the challenge of early detection and 10 management of these side effects while balancing the risk-benefit ratios of continuing with life-saving cancer therapy medications. This review will present the current knowledge related to incidence and proposed mechanisms of cardiovascular side effects of TKIs and also discuss treatment recommendations when available Expert opinion: We will present and discuss available data and suggest recommendations related to patient monitoring ...
How to Cut the Old Stems on a Dendrobium Orchid. Lovely, exotic spray orchids (Dendrobium phalaenopsis) are a tempting purchase when they are in full bloom. The common spray orchid has a two-part stem ranging from 12 to 40 inches long comprising a pseudobulb with leaves on its upper half and a smooth, slender flower ...
Dendrobium species, commonly known as Shihu or Huangcao, represents the second largest genus of Orchidaceae, which are used commonly as tonic herbs and healthy food in many Asian countries. The aim of this paper is to review the history, chemistry, and pharmacology of different Dendrobium species on the basis of the latest academic literatures found in Google Scholar, PubMed, Sciencedirect, Scopus, and SID.
Cancer stem cells (CSCs) have been recognized as rare populations driving cancer progression, metastasis, and drug resistance in leading cancers. Attempts have been paid toward identifying compound that specifically targets these CSCs. Therefore, the investigations of the novel therapeutic strategies for CSCs targeting is required. The cytotoxic effects of Chrysotoxine on human NSCLC-derived H460 and H23 cells were tested by MTT assay. The Effect of Chrysotoxine suppresses CSC-like phenotypes was determined in CSC-rich populations and primary CSCs in 3D culture and Extreme limiting dilution assay. Expression of CSC markers and associated proteins were determined by Western blot analyses and flow cytometry. We have reported the CSC-suppressing activity of Chrysotoxine, a bibenzyl compound isolated from Dendrobium pulchellum. We have shown for the first time that Chrysotoxine dramatically suppressed CSC-like phenotypes of human lung cancer H460 and H23 cells. Treatment of Chrysotoxine ...
Like a mini-conservatory, this simple whiteware square is lushly filled with greens and exotic flowers: two multi-blossomed Dendrobium orchid stems float airily above an ivy and moss ground to bring the beauty of the outdoors inside. Plant lovers will enjoy the harmony and balanced design in this tabletop garden. Add a package of Miracle Gro® Orchid Plant Food Spikes to keep your plant growing and thriving.
The Dendrobium orchid genus encompasses approximately 1,200 varieties. A wide range of sizes and flower colors exist. Some varieties sport flowers that last
Global Dendrobium Luminous Pills Market research study report is a respected source of information which offers a telescopic view of the current market sta
To confirm the registration of a Dendrobium hybrid & view its composition/progeny: (Database as at 1 January 2018 RHS registrations). ...
DEar Jeanne, Thank you for this information. I know we and the whole world is waiting and praying for its success. This is in the category of endostatin and angiogenesis that Dr. Judah Volkman has worked so hard to get into trials all these years. We owe him a world of gratitude as well. Thank you Jeanne, God Bless You, marty and Barb Auslander Jeanne Kissinger wrote: , , I am looking for the clinical trial criteria for this trial. No luck yet , and have to go. Lil? Marty? Whoever. I talked to the clinical trials , nurse and she said to get it off the web. I have pulled up quite a list , off alltheweb.com just type in Oxigene, no quotes needed. Jeanne , , http://www.oxigene.com/press/11-5-99.htm , , OXiGENE PRESENTS INTERIM COMBRETASTATIN A4 PRODRUG , PHASE I CLINICAL TRIAL RESULTS , , - New Clinical Data on Anti-Tumor Vascular Targeting Agent Presented , at the Chemotherapy Foundation Symposium - , , Boston, MA and Stockholm, Sweden, November 5, 1999-OXiGENE, Inc. , (Nasdaq: OXGN, SSE: OXGN) ...
Slug radula. Coloured scanning electron micrograph (SEM) of the radula from a red slug (Arion rufus). The radula is a tongue-like organ found in most molluscs. It is studded with rows of horny teeth (grey), which are used to rasp food particles from surfaces. Magnification: x660 when printed at 10 centimetres wide. - Stock Image C020/8738
liverwort is a plant. people make medicinal drug out of the fresh or dried components that develop above the ground. notwithstanding critical protection...
Time flies so fast... As a new blogger, its hard to believe that I have already made 1,000 posts on my blog. I started blogging on Ju ...
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To shutdown it I have to explicitly type a shutdown command, and even this way the window dont get closed. I have to close it using Power off the machine ...
The government shutdown is likely to mean an early death for thousands of mice used in research on diseases such as diabetes, cancer and Alzheimer's.
The stilbenic compound (Z)-combretastatin A-4 (CA-4) has been described as a potent tubulin polymerization inhibitor. In vivo, CA-4 binds to tubulin and inhibits microtubule depolymerization, which results in morphological changes in proliferating endothelial cells. Combretastatin A-4 prodrug phosphate is a leading vascular disrupting agent and is currently being evaluated in multiple clinical trials as a treatment for solid tumors. The aim of this study was to identify and characterize the UDP-glucuronosyltransferase (UGT) isoforms involved in CA-4 glucuronidation by incubation with human liver microsomes and a panel of nine liver-expressed recombinant UGT Supersomes (1A1, 1A3, 1A4, 1A6, 1A9, 2B4, 2B7, 2B15, and 2B17). As we observed, the high rate of formation of CA-4 glucuronide (Vmax = 12.78 ± 0.29 nmol/min/mg protein) and the low Km (6.98 ± 0.65 μM) denoted that UGT1A9 was primarily responsible for the in vitro glucuronidation of CA-4. UGT1A6 was also a significant contributor to CA-4 ...
SOUTH SAN FRANCISCO, Calif., March 20, 2013 (GLOBE NEWSWIRE) -- OXiGENE, Inc. (Nasdaq:OXGN), a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer, announced today that the US Patent and Trademark Office issued U.S. Patent No. 8,397,859, covering certain benzosuberene-based compounds, including the analogues referred to as KGP18 and KGP156 that are currently in preclinical development. The patent also covers methods of using those compounds to inhibit tubulin polymerization, to reduce blood flow to a tumor, or to restrain, slow, stop or reverse progression of a tumor.. These compounds are the product of OXiGENEs ongoing collaboration with Kevin G. Pinney, Ph.D. and Mary Lynn Trawick, Ph.D.at Baylor University to identify inhibitors of tubulin polymerization as vascular targeting agents and as back-up compounds to OXiGENEs combretastatin A-4P (ZYBRESTAT®) and OXi4503. Recently, the focus of this collaboration has centered on the development of novel ...
In 1991, Denekamp and Hill (36) framed the concept of vascular targeting. The target is either the endothelial cells lining tumor vessels or a protein product elaborated by tumor endothelium (37 , 38) . Antitumor effects in this instance are mediated either by induction of endothelial and/or subsequent tumor cell apoptosis or via vascular shutdown with resultant hemorrhagic necrosis (39 , 40) . There are important biological differences between normal and tumor blood vessels, which provides a scientific rationale for vascular targeting and therapeutic exploitation. These differences include the constant remodeling of tumor vessels as opposed to the quiescent endothelium of normal vasculature, a lack of associated pericytes, and the greater vascular permeability of tumor vessels (39, 40, 41, 42, 43) .. The precise mechanism of combretastatin induction of vascular shutdown is not clear. It is postulated that cytoskeletal changes in endothelial cells, as a result of tubulin-binding, may contribute ...
Lexibulin, also known as CYT997, is a n orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Check for active clinical trials or closed clinical trials using this agent.
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Mr. Arnold.....quick question, I know that there is a lot of speculation regarding DMAA and dendrobium........is there something out there that is new/
Strategies for improving the clinical efficacy of photodynamic therapy (PDT) in treatment of solid cancers include applications of different types of adjuvant treatments in addition to this modality that may result in superior therapeutic outcome. Examples of such an approach investigated using mouse tumor models are presented in this report. It is shown that the cures of PDT treated subcutaneous tumors can be substantially improved by adjuvant therapy with: metoclopramide (enhancement of cancer cell apoptosis), combretastatin A-4 (selective destruction of tumor neovasculature), Roussins Black Salt (light activated tumor localized release of nitric oxide), or dendritic cell-based adoptive immunotherapy (immune rejection of treated tumor ...
Importantly, because many different definitions of cancer therapeutics-related cardiac dysfunction have been used historically, the committee specifically defined cardiotoxicity or cancer therapeutics-related cardiac dysfunction as a decrease in LVEF ,10 percentage points to a value ,53%, which is the normal reference value for two-dimensional echocardiogram. This expert consensus also acknowledged the use of global longitudinal strain as a potential marker for early detection of cardiotoxicity during cancer therapy.. A reduction of ,15% in global longitudinal strain from baseline immediately after or during anthracycline therapy may be predictive of cardiotoxicity; a reduction ,8% may not be clinically significant. The use of cardiac imaging was left to clinician discretion, but echocardiogram was recommended as the preferred imaging modality when performed. The panel also suggested the use of serum biomarker evaluation, including troponin and BNP, but did not mandate testing due to a lack of ...
Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled
Comanda aici: http://livrarefloricadou.ro/home/72-buchet-mireasa-hortensii-albastre-si-orhidee-phalaenopsis-alb-bm03.html Flowers ...
Dendrocoryne kingianum (Bidwill ex Lindl.) Brieger in F.R.R.Schlechter, Die Orchideen; Beschreib. Kult. Zücht., ed. 3, 1(11-12): 724 (1981 ...
Question 3: Another so-called radula has been reported from the early Cambrian in 1974, this one preserved with fragments of the mineral ________ suspended in a quartz matrix, and showing similarities to the radula of the modern cephalopod Sepia. ...
The dextrorotary (R)-(+)-enantiomer is the most pharmacologically active, although a variety of related derivatives have been studied.[3] Side effects including chest pain (suggestive of possible cardiovascular toxicity) have been seen following recreational use of diphenylprolinol, although it was combined with glaucine in a party pill product, thus making it impossible to say for certain which drug was responsible.[4] ...
Disclosed is a pharmaceutical composition including a therapeutic quantity of a COX-2 inhibitor having an IC50-WHMA COX-2/COX-1 ratio ranging from about 0.23 to about 3.33 with reduced gastrointestinal and cardiovascular toxicity. Also disclosed are methods for treating osteoarthritis, rheumatoid arthritis or acute pain with less side-effects and faster onset of action utilizing the disclosed pharmaceutical composition.
3. COX-2 inhibitors, including celecoxib (brand name Celebrex). Two drugs in this class have been withdrawn from the market because of cardiovascular toxicity: rofecoxib (brand name Vioxx), and valdecoxib (brand name Bextra). These drugs are a special class of NSAID that were developed to be safer for the stomach, but have the same risk as other NSAIDs for kidney damage ...
COX-2 inhibitors, including celecoxib (brand name Celebrex). Two drugs in this class have already been withdrawn from the market because of cardiovascular toxicity: rofecoxib (brand name Vioxx), and valdecoxib (brand name Bextra). These drugs are a special class of NSAID and were developed to be safer for the stomach, but have the same risk as other NSAIDs do for kidney damage ...
Synthesis of an 8-Methoxy Pentacycline AnalogReagents: (a) bis(pinacolato)diboron, KOAc, PdCl2(dppf)-CH2Cl2, 1,4-dioxane, then H2O2, HOAc, THF; (b) CH3I, K2CO
The objective of the reserch was to know the effect of the acclimatization medium and the tipe foliar fertilizer on the growth of the crossed a Dendrobium sp orchid. The research was conducted at the Research and Tecnology ...
Re: [dts] [PATCH V1] tests/shutdown_api:change crc-strip command 2019-09-11 12:00 [dts] [PATCH V1] tests/shutdown_api:change crc-strip command Wenjie Li @ 2019-09-11 6:17 ` Yao, BingX Y 2019-10-12 6:49 ` Tu, Lijuan 1 sibling, 0 replies; 3+ messages in thread From: Yao, BingX Y @ 2019-09-11 6:17 UTC (permalink / raw) To: Li, WenjieX A, dts; +Cc: Li, WenjieX A [-- Attachment #1: Type: text/plain, Size: 1568 bytes --] Tested-by: Yao, BingX Y ,[email protected], -----Original Message----- From: dts [mailto:[email protected]] On Behalf Of Wenjie Li Sent: Wednesday, September 11, 2019 8:01 PM To: [email protected] Cc: Li, WenjieX A ,[email protected], Subject: [dts] [PATCH V1] tests/shutdown_api:change crc-strip command In dpdk commit e5db17a1e54e419419, port config all crc-strip,scatter, rx-cksum,rx-timestamp,hw-vlan,hw-vlan-filter,hw-vlan-strip,hw-vlan-extend on,off was deleted, use port config [port_id] rx_offload keep_crc off instead of port config all crc-strip on. Signed-off-by: ...
Pleťový krém LA ROCHE-POSAY Effaclar MAT 40 ml, |p>Bohaté zloženie pleťového krému Effaclar MAT obsahuje okrem iného termálnu vodu La Roche-Posay, ktorá jedinečným spôsobom upokojuje podráždenie.|/p>
With about 41% of the US Food and Drug Administration off the job due to the government shutdown, some agency employees worry about the safety and health of the American public.
In the big picture, the government shutdown will stop 800,000 Americans from getting paid and could cost the economy about $1 billion a week.
Your primary healthcare provider may be the first healthcare provider to evaluate you for epilepsy. He or she may then refer you to a specialist for further evaluation. This specialist may be a neurologist (a healthcare provider who treats the brain), or an epileptologist, a neurologist who specializes in seizure disorders. Your evaluation will include a medical history, physical and neurologic exams, and tests.
Bis(bibenzyls) and macrocyclic bis(benzyls) can be found in bryophytes, such as the compounds plagiochin E, 13,13'-O- ... Prenylated bibenzyls can be isolated from the New Zealand liverwort Marsupidium epiphytum or from Radula kojana. One unique ... doi:10.1016/S0031-9422(96)00387-1. Guo, H; Xing, J; Xie, C; Qu, J; Gao, Y; Lou, H (2007). "Study of bis(bibenzyls) in ... Bibenzyls (3,4'-dihydroxy-5,5'-dimethoxybibenzyl, 3,3'-dihydroxy-5-methoxybibenzyl (batatasin III)) can be found in the orchid ...
Bis(bibenzyls): 13,13'-O-Isoproylidenericcardin D. *Marchantin B and E. *Neomarchantin A ...
Phenolics can also be found in non-vascular land plants (bryophytes). Dihydrostilbenoids and bis(bibenzyls) can be found in ...
Bis(bibenzyls): 13,13-O-Isoproylidenericcardin D. *Marchantin B and E. *Neomarchantin A ...
Bis(bibenzyls) and macrocyclic bis(benzyls) can be found in bryophytes, such as the compounds plagiochin E, 13,13-O- ... Prenylated bibenzyls can be isolated from the New Zealand liverwort Marsupidium epiphytum or from Radula kojana. One unique ... doi:10.1016/S0031-9422(96)00387-1. Guo, H; Xing, J; Xie, C; Qu, J; Gao, Y; Lou, H (2007). "Study of bis(bibenzyls) in ... Bibenzyls (3,4-dihydroxy-5,5-dimethoxybibenzyl, 3,3-dihydroxy-5-methoxybibenzyl (batatasin III)) can be found in the orchid ...
Prenylated Bibenzyls from the Liverwort Radula laxiramea. Cullmann, Frank / Becker, Hans Page 147 ...
Short microwave-assisted modular synthesis of naturally occurring oxygenated bibenzyls. Krauss, Jürgen / Kopp, Ursula / Bracher ...
Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis.. Anchang KY, Novakovic M, Bukvicki D, Asakawa Y. ...
Terpenoids and Bibenzyls from Three Argentine Liverworts. Choose your preferred view mode. Please select whether you prefer to ...
Asakawa, Y., Toyota, M., and Takemoto, T. (1978). 7 new bibenzyls and a dihydrochalcone from radula-variabilis. Phytochemistry ...
Bibenzyls and phenanthrenoids of some species of Orchidaceae. Phytochemistry 28(11):3031-3034, 1989.. 5. Majumder PL, Sen S. ...
Syntheses of Bibenzyls, Olefins, and Related Compounds. Hiroyuki Higuchi, Tetsuo Otsubo, Fumio Ogura, Hachiro Yamaguchi, Yoshi ... Selenides and diselenides bound with an active methylene group like benzyl gave a variety of substituted bibenzyls and related ...
24] had quantified bibenzyls, phenanthrenes, and flavanones, which are used for plant identification among the Dendrobium ...
Journal Article] Bis(bibenzyls)from liverworts inhibit lipopolysacchariade-inducible NOS in RAW 264.7 cells : a study of ... Journal Article] Bis(bibenzyls)from liverworts inhibit lipopolysacchariade-inducible NOS in RAW 264.7 cells : a study of ... Journal Article] Chemical constituents of Malagasy liverworts, Part V : Prenyl bibenzyls and clerodane diterpenoids with nitric ... Journal Article] Chemical constituents of Malagasy liverworts, Part V : Prenyl bibenzyls and clerodane diterpenoids with nitric ...
Stilbenes and Bibenzyls with Potential Anticancer or Chemopreventive Activity Fulvia Orsini, Luisella Verotta ...
P. Chanvorachote, A. Kowitdamrong, T. Ruanghirun et al., "Anti-metastatic activities of bibenzyls from Dendrobium pulchellum," ...
Total Syntheses of Plagiochins A and D, Macrocyclic Bis(bibenzyls), by Pd(0) Catalyzed Intramolecular Stille-Kelly Reaction ( ...
Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: A study of structure- ... Liva Harinantenaina, Dang Ngoc Quang, T. Nishizawa, K. Soma, Y. Asakawa Bis(bibenzyls) from liverworts inhibit LPS induced iNOS ... Chemical Constituents of Malagasy Liverworts, Part V: Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory ... Chemical constituents of malagasy liverworts, Part V: Prenyl bibenzyls and clerodane diterpenoids with nitric oxide inhibitory ...
New Alloaromadendrane, Cadinene and Cyclocopacamphane Type Sesquiterpene Derivatives and Bibenzyls from Dendrobium nobile.. ...
Pharmacologic evaluation showed the bibenzyls possessed remarkable anti-tumor activity in vitro. A new antidepressant ...
Chemical Constituents of Malagasy Liverworts, Part V : Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory ...
... and five known bibenzyls (14-18). The new compounds included eight dihydro-dibenzoxepine (1-8), a dihydrobenzofuran (9), a ...
Asakawa Yoshinori, Toyota Masao, Takemoto Tsunematsu: Seven new bibenzyls and a dihydrochalcone from Radula variabilis. ... Asakawa Yoshinori, Tanikawa Kazuaki, Aratani Takaaki: New substituted bibenzyls of Frullania brittoniae subsp. Truncatifolia. ...
Bioactive polychlorinated bibenzyls from the liverwort Riccardia polyclada. Journal of Natural Products 70: 2019-2021. [ Links ... Sesquiterpenoids, hopanoids and bis(bibenzyls) from the Argentine liverwort Plagiochasma rupestre. Phytochemistry 52: 1323-1329 ... and bis-bibenzyls and marchantin A have been isolated from M. polymorpha and M. chenopoda (Asakawa et al. 2009). M. polymorpha ...
8. Distribution of Bibenzyls, Prenyl Bibenzyls, Bis-bibenzyls, and Terpenoids in the Liverwort Genus Radula ... Plants of the Radula genus are chemically very distinct from the other liverworts since they mainly elaborate bibenzyls ... including bibenzyl cannabinoids and prenyl bibenzyl derivatives, as well as bis-bibenzyls. Several of these components show ...
... one chemotype can produce bis bibenzyls (type I a?? collected in Singapore), while the other one does not have that capability ... type II a?? collected in Vietnam). This is the first report of the isolation of bis bibenzyls in the family Pallaviciniaceae. ...
unsubstituted)-7 ,8 -dihydro [1,2,4] triazolo[3,4-b][1,3,4]-thiadiazepin-3 yl}methoxy]bi-benzyls 4a-m under microwave ...
Bibenzyls / ビスビベンジル類 / Monoterpenes / 薬用植物 / 苔類の辛味成分 / トリテルペン / 抗メラノーマ / 生理活性テルペノイド / キリシマゴケ / bis-bibenzyls / LS-MS / 微生物変換 / ... Presentation] Several Novel Biological Activities of Macrocyclic Bis(bibenzyls)from Liverworts2009. *. Author(s). 橋本敏弘, 浅川義範 ... Journal Article] Marchantiophyta (Liverworts) : Rich sources of macrocyclic bis(bibenzyls).2008. *. Author(s). Asakawa, Y., ... Presentation] Distribution of volatile bibenzyls and tocopherols in liverworts
Anti-metastatic activities of bibenzyls from Dendrobium pulchellum. Nat Prod Comm, 8: 115-118 ...
Baum, G., Bergström, M. R., Clendenin, J. E., Ehrlich, R. D., Hughes, V. W., Kondo, K., Lubell, M. S., Miyashita, S., Miller, R. H., Palmer, D. A., Raith, W., Sasao, N., Scḧller, K. P. & Souder, P. A., 1980, In : Physical Review Letters. 45, 25, p. 2000-2003 4 p.. Research output: Contribution to journal › Article ...
Cooper, P. S., Alguard, M. J., Ehrlich, R. D., Hughes, V. W., Kobayakawa, H., Ladish, J. S., Lubell, M. S., Sasao, N., Schüler, K. P., Souder, P. A., Coward, D. H., Miller, R. H., Prescott, C. Y., Sherden, D. J., Sinclair, C. K., Baum, G., Raith, W. & Kondo, K., Jan 1 1979, In : Physical Review Letters. 42, 21, p. 1386-1389 4 p.. Research output: Contribution to journal › Article ...
  • Distribution of Bibenzyls, Prenyl Bibenzyls, Bis-bibenzyl. (dhpforum.nl)
  • Prenylated bibenzyls can be isolated from the New Zealand liverwort Marsupidium epiphytum or from Radula kojana. (wikipedia.org)
  • Asakawa Yoshinori, Toyota Masao, Takemoto Tsunematsu: Seven new bibenzyls and a dihydrochalcone from Radula variabilis. (cas.cz)
  • Balantiopsis rosea produced quite interesting 1-cyclohexy1-2-phenyl ethane derivatives which were suggested to be the biosynthetic precursors of the typical bibenzyls and … More bisbibinzyls which were peculiar secondary metabolites of liverworts. (nii.ac.jp)
  • 9. In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from the liverworts against Trypanosoma brucei. (bunri-u.ac.jp)
  • 10. Distribution of cyclic and acyclic bis-bibenzyls in the Marchantiophyta (liverworts), ferns and higher plants and their biological activity, biosynthesis, and total synthesis. (bunri-u.ac.jp)
  • Ludwiczuk, A. Distribution of cyclic and acyclic bis-bibenzyls in the Marchantiophyta (liverworts), ferns and higher plants and their biological activities, biosynthesis and total synthesis. (eurekaselect.com)
  • Bis(bibenzyls) and macrocyclic bis(benzyls) can be found in bryophytes, such as the compounds plagiochin E, 13,13'-O-isoproylidenericcardin D, riccardin H, marchantin E, neomarchantin A, marchantin A and marchantin B in the Chinese liverwort Marchantia polymorpha. (wikipedia.org)
  • Asakawa Yoshinori, Tanikawa Kazuaki, Aratani Takaaki: New substituted bibenzyls of Frullania brittoniae subsp. (cas.cz)