Bibenzyls: Compounds with 1,2-diphenylethane. They are structurally like reduced STILBENES.Hepatophyta: A plant division. They are simple plants that lack vascular tissue and possess rudimentary rootlike organs (rhizoids). Like MOSSES, liverworts have alternation of generations between haploid gamete-bearing forms (gametophytes) and diploid spore-bearing forms (sporophytes).Neoprene: An oil-resistant synthetic rubber made by the polymerization of chloroprene.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Taxes: Governmental levies on property, inheritance, gifts, etc.Prescription Fees: The charge levied on the consumer for drugs or therapy prescribed under written order of a physician or other health professional.Philately: Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.Great BritainGermanyMedicine, Arabic: Traditional Arabic methods used in medicine in the ARAB WORLD.Heligmosomatoidea: A superfamily of parasitic nematodes which were formerly considered a part of TRICHOSTRONGYLOIDEA. It includes the following genera: Heligmosomum, NEMATOSPIROIDES, and NIPPOSTRONGYLUS. The hosts are rodents.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Ferns: Seedless nonflowering plants of the class Filicinae. They reproduce by spores that appear as dots on the underside of feathery fronds. In earlier classifications the Pteridophyta included the club mosses, horsetails, ferns, and various fossil groups. In more recent classifications, pteridophytes and spermatophytes (seed-bearing plants) are classified in the Subkingdom Tracheobionta (also known as Tracheophyta).Bryophyta: A division of the plant kingdom. Bryophyta contains the subdivision, Musci, which contains the classes: Andreaeopsida, BRYOPSIDA, and SPHAGNOPSIDA.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Salacia: A plant genus of the family CELASTRACEAE. Members contain friedelane-type TRITERPENES and SESQUITERPENES, EUDESMANE.Opioid Peptides: The endogenous peptides with opiate-like activity. The three major classes currently recognized are the ENKEPHALINS, the DYNORPHINS, and the ENDORPHINS. Each of these families derives from different precursors, proenkephalin, prodynorphin, and PRO-OPIOMELANOCORTIN, respectively. There are also at least three classes of OPIOID RECEPTORS, but the peptide families do not map to the receptors in a simple way.Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.Receptors, Opioid: Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.Neurites: In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Ulmus: A plant genus of the family ULMACEAE that is susceptible to Dutch elm disease which is caused by the ASCOMYCOTA fungus, Ophiostoma.Angelica: A plant genus of the family Apiaceae.Dystroglycans: Dystrophin-associated proteins that play role in the formation of a transmembrane link between laminin-2 and DYSTROPHIN. Both the alpha and the beta subtypes of dystroglycan originate via POST-TRANSLATIONAL PROTEIN PROCESSING of a single precursor protein.Transition Elements: Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Dipetalonema Infections: Infections with nematodes of the genus DIPETALONEMA.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Organosilicon Compounds: Organic compounds that contain silicon as an integral part of the molecule.Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Humic Substances: Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Galaxies: Large aggregates of CELESTIAL STARS; COSMIC DUST; and gas. (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed)Phenol: An antiseptic and disinfectant aromatic alcohol.Ice Cream: A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.Stars, Celestial: Large bodies consisting of self-luminous gas held together by their own gravity. (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed)Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.

Erianin induces apoptosis in human leukemia HL-60 cells. (1/44)

AIM: To investigate the effect of erianin on human HL-60 cell line and explore its mechanism of apoptosis in vitro. METHODS: Inhibition of proliferation was measured with colorimetric MTT assay. The morphologic changes were observed by fluorescence and electron microscopes. DNA fragmentation was visualized by agarose gel electrophoresis, and the DNA degradation was determined by flow cytometry. Immunohistochemical analysis was used to identify the expression of bcl-2 and bax genes. RESULTS: The growth of human HL-60 cells was significantly inhibited by erianin 20-81.9 nmol/L during 72 h treatment (P < 0.01). The IC50 value was 38 nmol/L after a 24-h exposure to erianin, while that of vincristine, the positive control, was 101 nmol/L. The typical morphologic changes were observed and the nuclear DNA fragmentation exhibited "ladder" pattern. The cell cycle of HL-60 cells was arrested in G2/M phase, and expression of bcl-2 gene was decreased while that of bax was increased. CONCLUSION: Erianin showed potent inhibitory activity on the proliferation of HL-60 cells. The inhibition might be relative to the apoptosis induced by erianin and the altered expression of bcl-2 and bax genes in HL-60 cells.  (+info)

The biology of the combretastatins as tumour vascular targeting agents. (2/44)

The tumour vasculature is an attractive target for therapy. Combretastatin A-4 (CA-4) and A-1 (CA-1) are tubulin binding agents, structurally related to colchicine, which induce vascular-mediated tumour necrosis in animal models. CA-1 and CA-4 were isolated from the African bush willow, Combretum caffrum, and several synthetic analogues are also now available, such as the Aventis Pharma compound, AVE8062. More soluble, phosphated, forms of CA-4 (CA-4-P) and CA-1 (CA-1-P) are commonly used for in vitro and in vivo studies. These are cleaved to the natural forms by endogenous phosphatases and are taken up into cells. The lead compound, CA-4-P, is currently in clinical trial as a tumour vascular targeting agent. In animal models, CA-4-P causes a prolonged and extensive shut-down of blood flow in established tumour blood vessels, with much less effect in normal tissues. This paper reviews the current understanding of the mechanism of action of the combretastatins and their therapeutic potential.  (+info)

New bibenzyl cannabinoid from the New Zealand liverwort Radula marginata. (3/44)

The ether extract of the New Zealand liverwort Radula marginata afforded a new cannabinoid type bibenzyl compound named perrottetinenic acid, and two new bibenzyls, together with a known cannabinoid, perrottetinene. Their structures were established by two dimensional (2D) NMR spectral data. The structure of perrottetinenic acid was a similar to that of Delta(1)-tetrahydrocannabinol, a known hallucinogen. Cannabinoid type bibenzyls have been isolated from liverwort Radula perrottetii, though have not previously been reported from the liverwort R. marginata.  (+info)

Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. (4/44)

PURPOSE: A phase I trial was performed with combretastatin A4 phosphate (CA4P), a novel tubulin-binding agent that has been shown to rapidly reduce blood flow in animal tumors. PATIENTS AND METHODS: The drug was delivered by a 10-minute weekly infusion for 3 weeks followed by a week gap, with intrapatient dose escalation. Dose escalation was accomplished by doubling until grade 2 toxicity was seen. The starting dose was 5 mg/m2. RESULTS: Thirty-four patients received 167 infusions. CA4P was rapidly converted to the active combretastatin A4 (CA4), which was further metabolized to the glucuronide. CA4 area under the curve (AUC) increased from 0.169 at 5 mg/m2 to 3.29 micromol * h/L at 114 mg/m2. The mean CA4 AUC in eight patients at 68 mg/m2 was 2.33 micromol * h/L compared with 5.8 micromol * h/L at 25 mg/kg (the lowest effective dose) in the mouse. The only toxicity that possibly was related to the drug dose up to 40 mg/m2 was tumor pain. Dose-limiting toxicity was reversible ataxia at 114 mg/m2, vasovagal syncope and motor neuropathy at 88 mg/m2, and fatal ischemia in previously irradiated bowel at 52 mg/m2. Other drug-related grade 2 or higher toxicities seen in more than one patient were pain, lymphopenia, fatigue, anemia, diarrhea, hypertension, hypotension, vomiting, visual disturbance, and dyspnea. One patient at 68 mg/m2 had improvement in liver metastases of adrenocortical carcinoma. CONCLUSION: CA4P was well tolerated in 14 of 16 patients at 52 or 68 mg/m2; these are doses at which tumor blood flow reduction has been recorded.  (+info)

Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate. (5/44)

PURPOSE: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical trials, but recent preclinical studies have shown that CA1P displays a greater antitumor effect than the combretastatin A4 (CA4) analog at equal doses. The aim of this study, therefore, is to compare pharmacokinetics and metabolism of the two compounds to determine whether pharmacokinetics plays a role in their differential activity. EXPERIMENTAL DESIGN: NMRI mice bearing MAC29 tumors received injection with either CA4P or CA1P at a therapeutic dose of 150 mg x kg(-1), and profiles of both compounds and their metabolites analyzed by a sensitive and specific liquid chromatography/mass spectroscopy method. RESULTS: The metabolic profile of both compounds is complex, with up to 14 metabolites being detected for combretastatin A1 (CA1) in the plasma. Many of these metabolites have been identified by liquid chromatography/mass spectroscopy. Initial studies, however, focused on the active components CA4 and CA1, where plasma and tumor areas under the curve were 18.4 and 60.1 microg x h x ml(-1) for CA4, and 10.4 and 13.1 microg x h x ml(-1) for CA1, respectively. In vitro metabolic comparisons of the two compounds strongly suggest that CA1 is metabolized to a more reactive species than the CA4. CONCLUSIONS: Although in vitro studies suggest that variable rates of tumor-specific prodrug dephosphorylation may explain these differences in pharmacokinetics profiles, the improved antitumor activity and altered pharmacokinetic profile of CA1 may be due to the formation of a more reactive metabolite.  (+info)

Erianin induces a JNK/SAPK-dependent metabolic inhibition in human umbilical vein endothelial cells. (6/44)

BACKGROUND: Erianin is a natural product derived from Dendrobium chrysotoxum, with promising antitumor activity. MATERIALS AND METHODS: To evaluate the metabolic effect of erianin, a cytosensor assay for acidification rate, MTT assay, measurement of lactate, glucose and ATP were performed in human umbilical vein endothelial cells (HUVECs) exposed to 1-100 nM erianin. JNK/SAPK activity was detected by Western blot. RESULTS: Twelve- or 24- hour incubation with erianin induced a dose-dependent metabolic inhibition, as indicated by reduced acidification rate and cell viability, with an endothelium-selectivity. Erianin caused decreases in lactate production, glucose consumption and intracellular ATP level. Pretreatment with the JNK/SAPK inhibitor SP600125 significantly abolished these inhibitory responses, and especially restored the erianin-induced decreases in ATP and the erianin-induced phosphorylation of JNK/SAPK with dose- and time- dependence. CONCLUSION: Erianin inhibited endothelial metabolism in a JNK/SAPK-dependent manner. This mechanism may be involved in the potential antitumnor and antiangiogenic actions of erianin.  (+info)

A dual-color fluorescence imaging-based system for the dissection of antiangiogenic and chemotherapeutic activity of molecules. (7/44)

We have developed a simple yet sensitive dual color fluorescence-based technique for dissecting the tumor-neovascularization relationship and evaluated the susceptibility of each component to therapeutic interventions. Green fluorescent protein (GFP)-expressing melanoma cells were cocultured with endothelial cells on different three-dimensional (3-D) matrices and exposed to multiple growth factors and molecules with established anti-angiogenic or anticancer activities. Cells were fixed and stained with propidium iodide, imaged using a confocal microscope, and stereologically analyzed. Three-dimensionality of the system was tested by depth-coding and pseudocolor 3-D reconstruction in the z-axis. Selective ablation of the tumor cells was affected by the anthracycline antibiotic doxorubicin. Treatment with vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) promoted the neovascular responses on matrigel and collagen-1 matrices. VEGF-induced angiogenesis was inhibited after treatment with combretastatin and thalidomide. In contrast, HGF exerted a protective effect against these anti-angiogenics in a matrigel matrix. However, this effect was lost when the matrix was substituted with collagen, suggesting that the extracellular matrix impinges on cellular function, possibly through an Akt-mediated mechanism. The VEGF-receptor antagonist PTK787 also selectively ablated the VEGF-induced angiogenic effect without inhibiting the HGF-induced response, demonstrating the sensitivity of the system to detect modulation of distinct signal cascades. The current model encompasses the possibility of studying tumor-angiogenesis-matrix interaction on the same platform, expanding the rapid screening of novel molecules in a simulated clinicopathological setting.  (+info)

Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. (8/44)

In the continuing search for effective treatments for cancer, the emerging model is the combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood vessel growth. However, the implementation of this strategy has faced two major obstacles. First, the long-term shutdown of tumour blood vessels by the anti-angiogenesis agent can prevent the tumour from receiving a therapeutic concentration of the chemotherapy agent. Second, inhibiting blood supply drives the intra-tumoural accumulation of hypoxia-inducible factor-1alpha (HIF1-alpha); overexpression of HIF1-alpha is correlated with increased tumour invasiveness and resistance to chemotherapy. Here we report the disease-driven engineering of a drug delivery system, a 'nanocell', which overcomes these barriers unique to solid tumours. The nanocell comprises a nuclear nanoparticle within an extranuclear pegylated-lipid envelope, and is preferentially taken up by the tumour. The nanocell enables a temporal release of two drugs: the outer envelope first releases an anti-angiogenesis agent, causing a vascular shutdown; the inner nanoparticle, which is trapped inside the tumour, then releases a chemotherapy agent. This focal release within a tumour results in improved therapeutic index with reduced toxicity. The technology can be extended to additional agents, so as to target multiple signalling pathways or distinct tumour compartments, enabling the model of an 'integrative' approach in cancer therapy.  (+info)

*Dihydrostilbenoid

Bis(bibenzyls) and macrocyclic bis(benzyls) can be found in bryophytes, such as the compounds plagiochin E, 13,13'-O- ... Prenylated bibenzyls can be isolated from the New Zealand liverwort Marsupidium epiphytum or from Radula kojana. One unique ... doi:10.1016/S0031-9422(96)00387-1. Guo, H; Xing, J; Xie, C; Qu, J; Gao, Y; Lou, H (2007). "Study of bis(bibenzyls) in ... Bibenzyls (3,4'-dihydroxy-5,5'-dimethoxybibenzyl, 3,3'-dihydroxy-5-methoxybibenzyl (batatasin III)) can be found in the orchid ...

*Marsupidium epiphytum

Prenylated bibenzyls can be isolated from M. epiphytum. Marsupidium epiphytum on Te Papa New Zealand's national museum website ... Toyota, Masao; Omatsu, Ikuko; Braggins, John; Asakawa, Yoshinori (2011). "Novel Prenyl Bibenzyls from the New Zealand Liverwort ...

*Phenanthrenoid

... dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum". Phytochemistry. 44 (1): 157-165. doi:10.1016/s0031- ...

*Bulbophyllum vaginatum

Phenanthrenes, dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum. Leong Y-W, KAng C-C, Harrison LJ and ...

*Perrottetinene

Cullmann F, Becker H. Prenylated bibenzyls from the liverwort Radula laxiramea. Zeitschrift für Naturforschung. 1999; 54(3-4): ...

*Argyrochosma nivea

Isonotholaenic acid, a dihydrostilbenoid, and other bibenzyls can be found in A. nivea. This compound shows an anti-chagasic ...

*Marchantia polymorpha

... produces the antifungal bis[bibenzyls] dihydrostilbenoids plagiochin E, 13,13'-O-isoproylidenericcardin D ...

*Phenols

... bibenzyls) can be found in liverworts (Marchantiophyta), for instance, the macrocycles cavicularin and riccardin C. Though ...

*Phanera purpurea

... bibenzyls, dibenzoxepins, mixture of phytol fatty esters, lutein, β-sitosterol, isoquercitin and astragalin. Sinou C, Forest F ...

*List of MeSH codes (D02)

... bibenzyls MeSH D02.455.426.559.389.140.400 --- 2-hydroxy-5-nitrobenzyl bromide MeSH D02.455.426.559.389.140.450 --- lignans ... bibenzyls MeSH D02.455.426.559.389.150.700.100 --- chlorotrianisene MeSH D02.455.426.559.389.150.700.125 --- clomiphene MeSH ...

*Plagiochasma intermedium

... on www.uniprot.org Antifungal macrocyclic bis(bibenzyls) from the Chinese liverwort Ptagiochasm ...

*Riccardin C

... bibenzyls) from the Chinese liverwort Ptagiochasm intermedlum L. Chun-Feng Xie, Jian-Bo Qu, Xiu-Zhen Wu, Na Liu, Mei Ji and ...
0060] Pharmaceutically acceptable prodrugs of the compounds of formula (I), (II) or (III) are derivatives which have chemically or metabolically cleavable groups and become, by solvolysis or under physiological conditions, the compounds of the present invention which are pharmaceutically active in vivo. Prodrugs of the compounds of formula (I), (II) or (III) may be formed in a conventional manner with a functional group of the compounds such as with an amino or a hydroxyl group. The prodrug derivative form often offers advantages of solubility, tissue compatibility or delayed release in a mammalian organism (see, Bundgaard, H., Design of Prodrugs, pp. 7-9, 21-24, Elsevier, Amsterdam 1985). When a compound employed in the present invention has a hydroxyl group, an acyloxy derivative prepared by reacting the hydroxyl group with a suitable acylhalide or a suitable acid anhydride is exemplified as a prodrug. An especially preferred acyloxy derivative as a prodrug is --OC(═O)--CH3, ...
Zybrestat (combretastatin A4 phosphate) is a prodrug that is converted to combretastatin inside the endothelial cells that line blood vessels. Combretastatin has a dual-mode of action, targeting both VE-cadherin, a junction protein that is important for endothelial cell survival, and the associated beta-catenin/AKT signalling pathway.. Once activated within the endothelial cell, it causes rapid collapse and necrosis of the tumours vascular structure.. As a reversible tubulin depolymerizing agent, combretastatin also causes tumour-associated endothelial cells to change from a flat to a round shape. This has the effect of plugging the blood vessels so depriving the tumour of the oxygen and nutrients it needs to survive.. Because the endothelial cells of tumours are immature they are much more sensitive to the effects of combretastatin than the endothelial cells of normal tissue.. ...
About ZYBRESTAT (fosbretabulin) ZYBRESTAT is being evaluated in a Phase 2 study of patients with NSCLC and other clinical trials. OXiGENE believes that ZYBRESTAT is poised to become an important product in a novel class of small-molecule drug candidates called vascular disrupting agents (VDAs). Through interaction with vascular endothelial cell cytoskeletal proteins, ZYBRESTAT selectively targets and collapses tumor vasculature, thereby depriving the tumor of oxygen and nutrients, causing death of tumor cells. In clinical trials in solid tumors, ZYBRESTAT has demonstrated potent and selective activity against tumor vasculature, as well as clinical activity against ATC, ovarian cancer and various other solid tumors. About OXiGENE OXiGENE is a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases. The Companys major focus is developing vascular disrupting agents (VDAs) that selectively disrupt abnormal blood vessels associated with solid tumor ...
Members of OXiGENEs management team will review first quarter results via a webcast and conference call today at 2:00 p.m. EDT (11:00 a.m. PDT). To listen to a live or an archived version of the audio webcast, please log on to the Companys website, www.oxigene.com. Under the "Investor Center" tab, select the link to "Presentations & Conference Calls.". OXiGENEs earnings conference call can also be heard live by dialing (888) 208-1507 in the United States and Canada, and (913) 312-0402 for international callers, five minutes prior to the beginning of the call. A replay will be available starting at 5:00 p.m. EDT (2:00 p.m. PDT) on August 4, 2008 and ending at 5:00 p.m. EDT (2:00 p.m. PDT) on Monday, August 11, 2008. To access the replay, please dial (888) 203-1112 if calling from the United States or Canada, or (719) 457-0820 from international locations. Please refer to replay pass code 6113741. About ZYBRESTAT (fosbretabulin) ZYBRESTAT is currently being evaluated in a pivotal registration ...
Re: [dts] [PATCH V2]tests/shutdown_api: fix cant create vf 2020-03-20 8:37 [dts] [PATCH V2]tests/shutdown_api: fix cant create vf Zeng Xiaoxiao 2020-03-20 9:02 ` Zeng, XiaoxiaoX @ 2020-03-24 6:51 ` Tu, Lijuan 1 sibling, 0 replies; 4+ messages in thread From: Tu, Lijuan @ 2020-03-24 6:51 UTC (permalink / raw) To: Zeng, XiaoxiaoX, dts; +Cc: Zeng, XiaoxiaoX Applied, thanks , -----Original Message----- , From: dts [mailto:[email protected]] On Behalf Of Zeng Xiaoxiao , Sent: Friday, March 20, 2020 4:38 PM , To: [email protected] , Cc: Zeng, XiaoxiaoX ,[email protected], , Subject: [dts] [PATCH V2]tests/shutdown_api: fix cant create vf , , Signed-off-by: Zeng Xiaoxiao ,[email protected], , --- , tests/TestSuite_shutdown_api.py , 6 +++++- , 1 file changed, 5 insertions(+), 1 deletion(-) , , diff --git a/tests/TestSuite_shutdown_api.py , b/tests/TestSuite_shutdown_api.py index 11d451b..8699e79 100644 , --- a/tests/TestSuite_shutdown_api.py , +++ b/tests/TestSuite_shutdown_api.py , @@ ...
From the stem bark of Salacia chinensis L. collected in Vietnam, eight triterpenoids were isolated, including one new natural product.Phytochemical studies has shown that the liverwort Pallavicinia lyellii may have two chemotypes: one chemotype can produce bis bibenzyls (type I a?? collected in Singapore), while the other one does not have that capability (type II a?? collected in Vietnam). This is the first report of the isolation of bis bibenzyls in the family Pallaviciniaceae. Both chemotypes, however, biosynthesized a number of complex modified labdane diterpenoids. Type II P. lyellii can produce Diels-Alder cycloaddition type dimeric diterpenoids. This is also the first report of 2-oxygenated labdane diterpenoid in liverworts.Bioassays screening for nociceptin receptor (NOP) ligand revealed that the crude extract of the Vietnamese P. lyellii has higher binding affinity to NOP than the endogenous ligand OFQ/N. Further investigation is needed in order to identify the potential NOP ligand from ...
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue.
Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery systems. However, a major drawback remains its toxicity to healthy tissue and the development of multi-drug resistance during prolonged treatment. This is why in our work we aimed to improve DOX delivery and reduce the toxicity by chemical conjugation with a new nanoplatform based on polymalic acid. For delivery into recipient cancer cells, DOX was conjugated via pH-sensitive hydrazone linkage along with polyethylene glycol (PEG) to a biodegradable, non-toxic and non-immunogenic nanoconjugate platform: poly(β-L-malic acid) (PMLA). DOX-nanoconjugates were found stable under physiological conditions and shown to successfully inhibit in vitro cancer cell growth of several invasive breast carcinoma cell lines such as MDA-MB-231 and MDA-MB- 468 and of primary glioma cell lines such as U87MG and U251.
TY - JOUR. T1 - Cardiovascular toxicities associated with immune checkpoint inhibitors. AU - Hu, Jiun Ruey. AU - Florido, Roberta. AU - Lipson, Evan. AU - Naidoo, Jarushka. AU - Ardehali, Reza. AU - Tocchetti, Carlo G.. AU - Lyon, Alexander R.. AU - Padera, Robert F.. AU - Johnson, Douglas B.. AU - Moslehi, Javid. PY - 2019/4/15. Y1 - 2019/4/15. N2 - Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in case series but have been underappreciated due to their recent emergence, difficulties in diagnosis and non-specific clinical manifestations. ICIs are antibodies that block negative regulators of the T cell immune response, including cytotoxic T lymphocyte-associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and PD-1 ligand (PD-L1). While ICIs have introduced a significant mortality benefit in several cancer types, the augmented immune response has led to a range of immune-related toxicities, including cardiovascular toxicity. ...
Vincent L,Kermani P,Young LM,Cheng J,Zhang F,Shido K,Lam G,Bompais-Vincent H,Zhu Z,Hicklin DJ,Bohlen P,Chaplin DJ, et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest 2005; 115: 2992-3006 ...
and mean vessel diameter R. The pre- and posttreatment histogram shapes of R are in qualitative agreement with those obtained in our study supporting a common mechanism of action for the 2 tubulin-binding agents. The peak in the histogram for pretreatment R occurs at a slightly higher vessel size in our study, which may be attributed to scaling problems as addressed later, and while the increases in median and upper quartile of R in our study were not significant, they found significant reductions in percentiles at 60% and below. Our finding is also in agreement with intravital microscopy data on CA4P activity showing that reduction in venule number is largest for small venules (diameter , 10 μm), and that reduction in arteriolar diameter occurs (11). The distribution of R in the current study may reflect the combination of these vascular effects. The reduction in vessels with radii in the interval (≈20-30 μm) could reflect the reported reduction in small venules. As the number of vessels ...
J. E. Heavner, C. F. Dryden, V. Sanghani, G. Huemer, A. Bessire, J. M. Badgwell; Severe Hypoxia Enhances Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Lightly Anesthetized Pigs. Anesthesiology 1992;77(1):142-147. Download citation file:. ...
Binding agents with differential activity can be provided, whereby certain activities of a first part of the binding agent are reduced or prevented until binding to a target occurs. This is useful if the binding agent is intended to bind both an effector cell and a target to be destroyed, because the effector cell can be protected from significant cell damage that might otherwise occur (e.g. due to premature activation of complement and/or ADCC). Such binding agents are useful in the treatment of cancer, for example.
Dendrobium antennatum - Flowering size,, Pot-grown plant, Plant size ca. 30cm, Flower size ca. 4 - 5cm, Semishade to sunny, Moderately damp, Temperate, May - September, No rest period
Université de Liège - ULg , Département clinique des animaux de compagnie et des équidés , Département clinique des animaux de compagnie et des équidés ,] ...
... ,Ampare Shutdown Manager 1.2 is A tool lets you manage your computers shutdown, restart or logoff.
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Im seeing mixed results in the field as to whether or not SMC Firmware Update 1.1 actually resolves, once and for all, the Random Shutdown Syndrome (RSS) affec...
Please Contact Us so we can correct the problem. Kindly copy and paste the "Error Details" that appear below into your message to us ...
TY - JOUR. T1 - Cardiovascular toxicity of tyrosine kinase inhibitors. AU - Mouhayar, Elie. AU - Durand, Jean Bernard. AU - Cortes, Jorge. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Introduction: Small-molecule tyrosine kinase inhibitors (TKIs) have revolutionized the management of many malignancies. However, they also have been shown to be associated with a certain degree of cardiovascular side effects that are often reversible. Areas covered: As the number of new TKIs continues to grow, it is expected that clinicians will be facing the challenge of early detection and 10 management of these side effects while balancing the risk-benefit ratios of continuing with life-saving cancer therapy medications. This review will present the current knowledge related to incidence and proposed mechanisms of cardiovascular side effects of TKIs and also discuss treatment recommendations when available Expert opinion: We will present and discuss available data and suggest recommendations related to patient monitoring ...
Dendrobium species, commonly known as "Shihu" or "Huangcao," represents the second largest genus of Orchidaceae, which are used commonly as tonic herbs and healthy food in many Asian countries. The aim of this paper is to review the history, chemistry, and pharmacology of different Dendrobium species on the basis of the latest academic literatures found in Google Scholar, PubMed, Sciencedirect, Scopus, and SID.
Cancer stem cells (CSCs) have been recognized as rare populations driving cancer progression, metastasis, and drug resistance in leading cancers. Attempts have been paid toward identifying compound that specifically targets these CSCs. Therefore, the investigations of the novel therapeutic strategies for CSCs targeting is required. The cytotoxic effects of Chrysotoxine on human NSCLC-derived H460 and H23 cells were tested by MTT assay. The Effect of Chrysotoxine suppresses CSC-like phenotypes was determined in CSC-rich populations and primary CSCs in 3D culture and Extreme limiting dilution assay. Expression of CSC markers and associated proteins were determined by Western blot analyses and flow cytometry. We have reported the CSC-suppressing activity of Chrysotoxine, a bibenzyl compound isolated from Dendrobium pulchellum. We have shown for the first time that Chrysotoxine dramatically suppressed CSC-like phenotypes of human lung cancer H460 and H23 cells. Treatment of Chrysotoxine ...
The Dendrobium orchid genus encompasses approximately 1,200 varieties. A wide range of sizes and flower colors exist. Some varieties sport flowers that last
Like a mini-conservatory, this simple whiteware square is lushly filled with greens and exotic flowers: two multi-blossomed Dendrobium orchid stems float airily above an ivy and moss ground to bring the beauty of the outdoors inside. Plant lovers will enjoy the harmony and balanced design in this tabletop garden. Add a package of Miracle Gro® Orchid Plant Food Spikes to keep your plant growing and thriving.
DEar Jeanne, Thank you for this information. I know we and the whole world is waiting and praying for its success. This is in the category of endostatin and angiogenesis that Dr. Judah Volkman has worked so hard to get into trials all these years. We owe him a world of gratitude as well. Thank you Jeanne, God Bless You, marty and Barb Auslander Jeanne Kissinger wrote: , , I am looking for the clinical trial criteria for this trial. No luck yet , and have to go. Lil? Marty? Whoever. I talked to the clinical trials , nurse and she said to get it off the web. I have pulled up quite a list , off alltheweb.com just type in Oxigene, no quotes needed. Jeanne , , http://www.oxigene.com/press/11-5-99.htm , , OXiGENE PRESENTS INTERIM COMBRETASTATIN A4 PRODRUG , PHASE I CLINICAL TRIAL RESULTS , , - New Clinical Data on Anti-Tumor Vascular Targeting Agent Presented , at the Chemotherapy Foundation Symposium - , , Boston, MA and Stockholm, Sweden, November 5, 1999-OXiGENE, Inc. , (Nasdaq: OXGN, SSE: OXGN) ...
Slug radula. Coloured scanning electron micrograph (SEM) of the radula from a red slug (Arion rufus). The radula is a tongue-like organ found in most molluscs. It is studded with rows of horny teeth (grey), which are used to rasp food particles from surfaces. Magnification: x660 when printed at 10 centimetres wide. - Stock Image C020/8738
... is a plant. people make medicinal drug out of the fresh or dried components that develop above the ground. notwithstanding critical protection...
Time flies so fast... As a new blogger, its hard to believe that I have already made 1,000 posts on my blog. I started blogging on Ju ...
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The government shutdown is likely to mean an early death for thousands of mice used in research on diseases such as diabetes, cancer and Alzheimer's.
SOUTH SAN FRANCISCO, Calif., March 20, 2013 (GLOBE NEWSWIRE) -- OXiGENE, Inc. (Nasdaq:OXGN), a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer, announced today that the US Patent and Trademark Office issued U.S. Patent No. 8,397,859, covering certain benzosuberene-based compounds, including the analogues referred to as KGP18 and KGP156 that are currently in preclinical development. The patent also covers methods of using those compounds to inhibit tubulin polymerization, to reduce blood flow to a tumor, or to restrain, slow, stop or reverse progression of a tumor.. These compounds are the product of OXiGENEs ongoing collaboration with Kevin G. Pinney, Ph.D. and Mary Lynn Trawick, Ph.D.at Baylor University to identify inhibitors of tubulin polymerization as vascular targeting agents and as back-up compounds to OXiGENEs combretastatin A-4P (ZYBRESTAT®) and OXi4503. Recently, the focus of this collaboration has centered on the development of novel ...
In 1991, Denekamp and Hill (36) framed the concept of vascular targeting. The target is either the endothelial cells lining tumor vessels or a protein product elaborated by tumor endothelium (37 , 38) . Antitumor effects in this instance are mediated either by induction of endothelial and/or subsequent tumor cell apoptosis or via vascular shutdown with resultant hemorrhagic necrosis (39 , 40) . There are important biological differences between normal and tumor blood vessels, which provides a scientific rationale for vascular targeting and therapeutic exploitation. These differences include the constant remodeling of tumor vessels as opposed to the quiescent endothelium of normal vasculature, a lack of associated pericytes, and the greater vascular permeability of tumor vessels (39, 40, 41, 42, 43) .. The precise mechanism of combretastatin induction of vascular shutdown is not clear. It is postulated that cytoskeletal changes in endothelial cells, as a result of tubulin-binding, may contribute ...
Lexibulin, also known as CYT997, is a n orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Check for active clinical trials or closed clinical trials using this agent.
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Mr. Arnold.....quick question, I know that there is a lot of speculation regarding DMAA and dendrobium........is there something out there that is new/
Importantly, because many different definitions of cancer therapeutics-related cardiac dysfunction have been used historically, the committee specifically defined cardiotoxicity or cancer therapeutics-related cardiac dysfunction as a decrease in LVEF ,10 percentage points to a value ,53%, which is the normal reference value for two-dimensional echocardiogram. This expert consensus also acknowledged the use of global longitudinal strain as a potential marker for early detection of cardiotoxicity during cancer therapy.. A reduction of ,15% in global longitudinal strain from baseline immediately after or during anthracycline therapy may be predictive of cardiotoxicity; a reduction ,8% may not be clinically significant. The use of cardiac imaging was left to clinician discretion, but echocardiogram was recommended as the preferred imaging modality when performed. The panel also suggested the use of serum biomarker evaluation, including troponin and BNP, but did not mandate testing due to a lack of ...
Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled
Comanda aici: http://livrarefloricadou.ro/home/72-buchet-mireasa-hortensii-albastre-si-orhidee-phalaenopsis-alb-bm03.html Flowers ...
Dendrocoryne kingianum (Bidwill ex Lindl.) Brieger in F.R.R.Schlechter, Die Orchideen; Beschreib. Kult. Zücht., ed. 3, 1(11-12): 724 (1981 ...
Question 3: Another so-called radula has been reported from the early Cambrian in 1974, this one preserved with fragments of the mineral ________ suspended in a quartz matrix, and showing similarities to the radula of the modern cephalopod Sepia. ...
Disclosed is a pharmaceutical composition including a therapeutic quantity of a COX-2 inhibitor having an IC50-WHMA COX-2/COX-1 ratio ranging from about 0.23 to about 3.33 with reduced gastrointestinal and cardiovascular toxicity. Also disclosed are methods for treating osteoarthritis, rheumatoid arthritis or acute pain with less side-effects and faster onset of action utilizing the disclosed pharmaceutical composition.
COX-2 inhibitors, including celecoxib (brand name Celebrex). Two drugs in this class have already been withdrawn from the market because of cardiovascular toxicity: rofecoxib (brand name Vioxx), and valdecoxib (brand name Bextra). These drugs are a special class of NSAID and were developed to be safer for the stomach, but have the same risk as other NSAIDs do for kidney damage ...
3. COX-2 inhibitors, including celecoxib (brand name Celebrex). Two drugs in this class have been withdrawn from the market because of cardiovascular toxicity: rofecoxib (brand name Vioxx), and valdecoxib (brand name Bextra). These drugs are a special class of NSAID that were developed to be safer for the stomach, but have the same risk as other NSAIDs for kidney damage ...
Synthesis of an 8-Methoxy Pentacycline AnalogReagents: (a) bis(pinacolato)diboron, KOAc, PdCl2(dppf)-CH2Cl2, 1,4-dioxane, then H2O2, HOAc, THF; (b) CH3I, K2CO
The objective of the reserch was to know the effect of the acclimatization medium and the tipe foliar fertilizer on the growth of the crossed a Dendrobium sp orchid. The research was conducted at the Research and Tecnology ...
Re: [dts] [PATCH V1] tests/shutdown_api:change crc-strip command 2019-09-11 12:00 [dts] [PATCH V1] tests/shutdown_api:change crc-strip command Wenjie Li @ 2019-09-11 6:17 ` Yao, BingX Y 2019-10-12 6:49 ` Tu, Lijuan 1 sibling, 0 replies; 3+ messages in thread From: Yao, BingX Y @ 2019-09-11 6:17 UTC (permalink / raw) To: Li, WenjieX A, dts; +Cc: Li, WenjieX A [-- Attachment #1: Type: text/plain, Size: 1568 bytes --] Tested-by: Yao, BingX Y ,[email protected], -----Original Message----- From: dts [mailto:[email protected]] On Behalf Of Wenjie Li Sent: Wednesday, September 11, 2019 8:01 PM To: [email protected] Cc: Li, WenjieX A ,[email protected], Subject: [dts] [PATCH V1] tests/shutdown_api:change crc-strip command In dpdk commit e5db17a1e54e419419, port config all crc-strip,scatter, rx-cksum,rx-timestamp,hw-vlan,hw-vlan-filter,hw-vlan-strip,hw-vlan-extend on,off was deleted, use port config [port_id] rx_offload keep_crc off instead of port config all crc-strip on. Signed-off-by: ...
Pleťový krém LA ROCHE-POSAY Effaclar MAT 40 ml, |p>Bohaté zloženie pleťového krému Effaclar MAT obsahuje okrem iného termálnu vodu La Roche-Posay, ktorá jedinečným spôsobom upokojuje podráždenie.|/p>
With about 41% of the US Food and Drug Administration off the job due to the government shutdown, some agency employees worry about the safety and health of the American public.
Your primary healthcare provider may be the first healthcare provider to evaluate you for epilepsy. He or she may then refer you to a specialist for further evaluation. This specialist may be a neurologist (a healthcare provider who treats the brain), or an epileptologist, a neurologist who specializes in seizure disorders. Your evaluation will include a medical history, physical and neurologic exams, and tests.
Tubulin-binding vascular-disrupting agents (VDA) are currently in clinical trials for cancer therapy but the factors that influence tumor susceptibility to these agents are poorly understood. We evaluated the consequences of modifying tumor vascular morphology and function on vascular and therapeutic response to combretastatin-A4 3-O-phosphate (CA-4-P), which was chosen as a model VDA. Mouse fibrosarcoma cell lines that are capable of expressing all vascular endothelial growth factor (VEGF) isoforms (control) or only single isoforms of VEGF (VEGF120, VEGF164, or VEGF188) were developed under endogenous VEGF promoter control. Once tumors were established, VEGF isoform expression did not affect growth or blood flow rate. However, VEGF188 was uniquely associated with tumor vascular maturity, resistance to hemorrhage, and resistance to CA-4-P. Pericyte staining was much greater in VEGF188 and control tumors than in VEGF120 and VEGF164 tumors. Vascular volume was highest in VEGF120 and control tumors ...
inproceedings{41c8c41b-a2f5-4475-8be9-0341dfcd092f, abstract = {In northern Sweden, Empetrum hermaphroditum Hagerup dominates the ground layer vegetation in post fire successions by suppressing other plant species. Previous studies suggest that this negative effect by E. hermaphroditum may be explained, at least in part, by the release of phenolic compounds, particularly batatasin-III, from foliage to soil. In this pilot study, we evaluated the effect of batatasin-III on photosynthesis by applying the compound (0.1, 1.0, or 2.8 mM) directly to the transpiration stream of intact Spinacia oleracea L. (spinach) and Betula pendula L. (birch) leaves. Within the concentration range used, batatasin-III had a small, but significant, effect on photosynthesis. The strongest effect was found on CO2 assimilation, but there were also significant effects on respiration and on maximum quantum yield of chlorophyll fluorescence (Fv / Fm). In spinach leaves treated with 2.8 mM of batatasin-III, a 14 % decrease in ...
Tests were conducted from 14 Jul through 8 Sep 1994 on 8 year old orchid plants at a commercial dendrobium farm in Kailua-Kona, Hawaii. Plants were growing in 1.3 cm crushed basaltic rock under 30% polypropylene shade using standard cultural practices. Experimental plots measured 40 square feet with 58 plants per plot arranged in a randomized complete block (RCB) with four blocks. Four weekly applications of insecticides were applied beginning 14 Jul and ending 4 Aug. A spreader-sticker (Ad-here, J.R. Simplot, Lanthrop, CA) was added to all foliar treatments, including the control, at a rate of 0.5 ml per liter solution. Insecticides were applied at 1,345 liters/ha using a backpack sprayer (Solo Inc., Newport News, VA) equipped with an 8004 Teejet nozzle (Spraying systems Co. Wheaton, IL) at 276 KPa. The control was sprayed with water. Treatment efficacy was evaluated by randomly harvesting 5 inflorescences weekly from each block. Blossoms were removed from the inflorescences, counted, and ...
Dendrobium loddigesii Rolfe is an endangered epiphytic orchid with extremely high medicinal and ornamental value. The stems of D. loddigesii are widely known as the most precious traditional Chinese m
The cultivation of particular species varies dramatically though generally a very well-drained mixture of bark and charcoal often with a bit of added sphagnum moss is the ideal growing medium In g
uncontrolled hypertension. The role of gastric decontamination where toxicity develops from recent excessive oral doses is not established. Ipecac-induced emesis is not recommended (Krenzelok, McGuigan & Lheur, 1997). Gastric lavage is unlikely to be of benefit if instituted more than one hour after ingestion (Vale, 1997) and there is no evidence to support its use in these patients even if they present within one hour. The possible neurological and cardiovascular toxicity could make such an intervention potentially dangerous. Similarly, activated charcoal is unlikely to be of benefit if instituted more than one hour after ingestion (Chyka & Seger, 1997) and it is unclear whether earlier administration would be of any benefit ...
WoRMS (2010). Nipponacmea radula (Kira, 1961). In: MolluscaBase (2017). Accessed through: World Register of Marine Species at http://www.marinespecies.org/aphia.php?p=taxdetails&id=456616 on 2017-12- ...
A shaped porous body for filtering and drying gases and liquids is formed of a solid adsorptive drying agent or adsorbent and about between 10 and 0.3 percent of a binding agent relative to the weight of said drying agent or adsorbent, the said binding agent consisting essentially of the reaction product between a di- or polyisocyanate and a polyester or polyetherpolyol which reaction product is hardened to a polyurethane.
Cymbidium,Phalaenopsis,dendrobium and Vanda are most popular orchids that are generally used in bouquets.Learn how to take care of these orchids.
The purpose of this study is to find out what effects, good and/or bad STA-9090 has on colorectal cancer. This is a phase II trial which tests both how
WILLOWBROOK, Ill. - Gov. Bruce Rauner is now calling for the shutdown of a suburban Chicago plant suspected of emitting chemically polluted fumes that could elevate the risk of cancer. Rauner on Tuesday joined a chorus of elected officials calling for the shutdown of a Sterigenics International facility in Willowbrook. For more than three decades […]
Trans-resveratrol is one form of a compound produced by some plants to combat fungal infection. When ingested, trans-resveratrol might provide health...
Question 5: [11] The overall physical similarity of some mosses and leafy liverworts means that confirmation of the identification of some groups can be performed with certainty only with the aid of ________ or an experienced bryologist. ...
... _VERTICAL TURBINE INSTALLATION, OPERATION ii WARRANTY Unless otherwise specifically stated, guarantees are limited to the following: A All equipment of our manufacture is guaranteed against def
From flu shots, to beer, to flailing consumer confidence, the effects of the government shutdown will be felt for months after it is over.
TrueResveratrol contains 75mg per serving (150mg recommended daily intake) of trans-resveratrol from naturally fermented Veri-te resveratrol.
Will a firm shut down in the short run if it is losing money, even though it can cover its fixed costs? Explain why this is true or false and include.
Six Southern California Edison employees Monday were hospitalized and 20 others were evaluated after a strong odor was detected from the companys call center in Long Beach.
The invention provides reagents and methods for multivalent binding and quantitative capture of components in a sample. In one aspect, reagents and methods for diagnostic assay for antigen, ligand, binding agent, or antibody are provided. Compositions of a non-natural or deliberately constructed nucleic acid-like polymeric scaffold are provided, to which multiple antibodies, peptides or other binding agents can be affixed by hybridization of a oligonucleotide: binding agent complex such that the nucleic acid: binding agent construction displays multivalent behavior when interacting with a multivalent analyte. Methods for constructing and using the scaffolds are described. Such compositions may include assembly of mixed specificity binding agents such that the composition displays multivalent binding behavior against a target containing mixed analytes which can be bound by the construct to effect a binding affinity increase such as is observed in avidity reagents against single analytes expressed
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Frullania pycnantha, Liverwort image
I am from K.L, Malaysia. These are my collection of exotic plants photos like orchids, fern allies (lycopodiums and platycerium), hoyas and nephentes in my garden located in K.L and my hometown in Pahang. I will be adding more photos and articles from time to time. So, just enjoy yourself! I will share my experience how to grow them in tropical climate. Thank you for visiting my blog ...
I am from K.L, Malaysia. These are my collection of exotic plants photos like orchids, fern allies (lycopodiums and platycerium), hoyas and nephentes in my garden located in K.L and my hometown in Pahang. I will be adding more photos and articles from time to time. So, just enjoy yourself! I will share my experience how to grow them in tropical climate. Thank you for visiting my blog ...
Blog on trans-Resveratrol 3-O- beta-D-Glucuronide biochemical product: The trans-Resveratrol 3-O- beta-D-Glucuronide n/a (Catalog #MBS6032148) is a Biochemical and is intended ...
Three more photos taken with the USB microscope. The top image is of the Marchantia polymorpha liverwort that grows on the surface of overwatered plants in my greenhouse. The objects in the centre of the cupule are tiny buds called gemmae, miniature liverworts that will begin to grow when they are splashed out onto the soil surface by the spray from the watering can. You can also see the air pores in the surface of the liverwort thallus quite nicely. The other two images are of a lesser celandine and a dandelion. One minor problem with this USB microscope is that the images can be a bit flat, especially if the objects are predominantly one colour, as the ring of LEDs that provides the illumination produces shadowless lighting. ...
The reaction of pinB-BMes2 (pin = pinacolato, Mes = 2,4,6-Me3C6H2) with Xyl-NC (Xyl = 2,6-Me2C6H3) and pyridine results in the formation of a pyridine-coordinated boraalkene that exhibits an intense color caused by an intramolecular charge-transfer interaction. In the presence of an excess of pyridine, the ortho C-
A binder mix containing a hydraulic binding agent and an admixture mixed therewith, a process for preparing a hydraulically hardened binder mass, a calcinated kaolin product and a process for preparing the same. A paste-like composition is formed from the hydraulically hardening binding agent, a pozzolanically reacting admixture and water, which, when so desired, contains stone aggregate or similar filler, the paste-like composition is worked and the worked composition is allowed to harden to form the binder mass. The admixture comprises spherical, porous metakaolin agglomerates, the size of which is 2-200 microns and which have an open pore structure. The invention can be used to improve the manufacturing methods of cast concrete products and shorten the manufacturing times, and to provide concrete with better mechanical and chemical properties, as well as improve the fire and frost resistance of concrete.
Garancia dodania do Vianoc ✓ Pleťové mlieko DERMACOL Cleansing Face Milk 200 ml, |p>Pleťové mlieko Cleansing je určené pre odstraňovanie nečistôt, odumretých pleťových buniek a prebytočného kožného mazu z normálnej a zmiešanej pleti.|/p>
Sparrowvsrevolution writes In the wake of Syrias 52-hour digital blackout last week, the networking firm Renesys performed an analysis of which countries are most susceptible to an Internet shutdown, based simply on how many distinct entities control the connections between the countrys networks ...
The House of Representatives voted Tuesday to pass a temporary spending measure, the first step in averting a government shutdown at weeks end. Lawmakers in the Republican-controlled chamber
MBAM, MSE shutdown, freezing and redirects! Ouch! - posted in Virus, Spyware, Malware Removal: My wifes D600 dell gets a regular scan with MBAM and has MSE ( only Av program) installed. Basics are XP Pro w/ SP3, Firefox, Thunderbird. She started complaining about freezing, sluggishness lately as well as losing emails , etc. Yesterday the MSE shutoff and would not start using the on screen dialog box. I tried to run a scan with MBAM but it wouldnt run either. Trying to go online I...
The potential for a partial shutdown Tuesday is a quirk of American history. So if youre bored with blaming House Republicans or President Barack Obama, you can lay some responsibility on the Founding Fathers.
The potential for a partial shutdown Tuesday is a quirk of American history. So if youre bored with blaming House Republicans or President Barack Obama, you can lay some responsibility on the Founding Fathers.
Skewed data and the economic setback of the partial government shutdown face Federal Reserve policymakers as they review their economic stimulus program on Tuesday and Wednesday.
Forty million dollars an hour. A third of a billion every day. $1.6 billion every week. Thats a conservative estimate of the shutdowns cost. If theres one…
New Zealand has a greater density of liverworts than any other country, due to its cool, wet and temperate climate. About half the species are endemic to New Zealand.. There are 606 species known in New Zealand. While these include some thallose liverworts, with liver-shaped thalli, most are leafy liverworts which can be confused with mosses and filmy ferns. Undescribed species, and those not previously recorded in New Zealand, continue to be found in lowland forests. Ninety species and varieties are listed on the 2001 Department of Conservation threatened plants list, and 157 liverwort species and varieties will be included on the next version of the list as a result of better knowledge of the group.. A three-volume work on liverworts in New Zealand is being written by John Engel and David Glenny, with the first volume published in 2008.[4] The first volume will also be placed online in June 2009 as part of Floraseries.[5]. ...
This amazing plant called psyllium is used as a binding agent when baking with nut flours. Learn about its medicinal properties and use it every day.
Resveratrol-forte® 175 mg High Potency. Live longer, live better!Overview Why is trans-resveratrol important? Trans-resveratrol is the most absorbable form. Better absorption means optimal anti-aging benefits. Why use Resveratrol-forte High Potency? Its convenient! Resveratrol-forte High Potency offers 175 mg of trans-resveratrol in an easy to swallow, one per day softgel. Amazing anti-aging benefits! * Activates the longevity enzyme to help slow the pace of aging with 175mg of 100% pure trans-resveratrol. * One dose of Resveratrol-forte anti-aging antioxidant† High Potency contains as much trans-resveratrol as 118 bottles of red wine.** Unique synergistic formula. * The combination of resveratrol and rutin (quercetin rutinoside) provides more anti-aging antioxidant and immune support than resveratrol alone. * Increased potency and stability come from the special extraction and purification methods. **Based on 175 mg trans-resveratrol dose, an
Here, we have performed a deletion analysis of Op18, the prototype member of a novel class of MT regulators, and identified regions involved in differential modulation of tubulin GTP metabolism. How these in vitro activities segregate from tubulin binding properties and specific MT-regulating activities in intact cells was determined to address the mechanism by which Op18 exerts its regulatory role. These analyses were facilitated by the maintenance of protein stability by all the truncations tested, which indicated that Op18 lacks distinct domain structures. Using these truncated Op18 proteins, physically separated tubulin binding motifs of both the NH2- and COOH-terminal regions were found to transmit distinct tubulin-directed signals. These signals were manifested on the level of modulation of both exchange and hydrolysis of tubulin-bound GTP (Fig. 2). By analyzing the activities of deleted Op18 derivatives in K562 cells, we obtained data most consistent with MT destabilization by a mechanism ...
Portions of the radula of A, Limnaea stagnalis L, with the central tooth and two first laterals, and two of the marginals, very highly magnified; B, Ancylus fluviatalis Mull, with two of the marginals very highly magnified; C, Physa fontinalis L., with central tooth and two of the marginals very highly ...
A team including DOE JGI scientists analyzed the common liverworts genome sequence to identify genes and gene families deemed crucial to plant evolution.
Looking for Calobryales? Find out information about Calobryales. An order of liverworts; characterized by prostrate, simple or branched, leafless stems and erect, leafy branches of a radial organization Explanation of Calobryales
A photo-sensitive composition for dry formation of image comprising a dyestuff having a photo-fading property, a ketonic sensitizing agent and a high molecular polymer as a binding agent, which can provide a visible image by the irradiation of light and maintain the image without any fixing treatment.
Ovocím pigmentovaný super jemný a ľahký kompaktný púder odtieň Peach Bisque s minerálnymi UV filtrami zaistí krásnu a bezchybnú pleť.
Pick your comparison. On Morning Edition, NPR's Mara Liasson went with a Lewis Carroll reference, saying there was a "down the rabbit hole"
A highly chemo- and stereoselective nickel-catalyzed borylative cyclization of 1,6-enynes with bis(pinacolato)diboron is described. Enynes containing an electron-deficient alkene such as a vinyl ketone provided alkenylboronates while enynes containing a terminal alkene gave homoallylic boronates. A plausible
European Commission - this page describes research project 108-Development and application of high throughput molecular methods for studying the human gut microbiota in relation to diet and health. It was funded within Key Action 1 - Food, Nutrition and Health - of the Quality of Life and Management of Living Resources, Fifth Framework Programme for RTD.
I guess they hadnt counted on THIS:South Dakota ranchers, who were in favor of the government shutdown, are now bemoaning the fact that the shutdown means no federal assistance following a devastating early blizzard that wiped out much of their livestock.Really?Whats worse is that the ranchers dont sound like theyve changed their minds about the shutdown.Rather, they think that their welfare checks from the government are the only good the government actually does. So while the rest of the government should still be shut down for you and me, we should make an exception for ... Read more
Tablet preparation in ayurveda is done using several binding agents which also serves as a medicine by themselves such as guggula, guda, sugar etc.
Tablet preparation in ayurveda is done using several binding agents which also serves as a medicine by themselves such as guggula, guda, sugar etc.
Regarding specific causal agents, bleomycin has the strongest association with RP. In a study of 395 patients with good-risk nonseminomas randomized to receive 4 cycles of etoposide and cisplatin with (BEP) or without bleomycin (EP), 8% of patients in the BEP arm developed acute RP compared with none in the EP arm.23 Vinblastine and cisplatin have also been implicated as contributing to this toxicity.15-18 For example, higher rates of digital ischemia were identified in patients treated with cisplatin compared with those who were not (41% vs. 21%).14 The cumulative dose of chemotherapy and the prevalence of conventional risk factors for peripheral arterial disease, such as hypertension or smoking, may also play a role.15,16. In vitro studies and laboratory findings further support a direct mechanism of cardiovascular disease through chemotherapy-induced endothelial dysfunction. For example, exposure of endothelial cells to cisplatin or bleomycin in vitro leads to endothelial cell cytokine ...

Zeitschrift für Naturforschung CZeitschrift für Naturforschung C

Prenylated Bibenzyls from the Liverwort Radula laxiramea. Cullmann, Frank / Becker, Hans Page 147 ...
more infohttps://www.degruyter.com/view/j/znc.1999.54.issue-3-4/issue-files/znc.1999.54.issue-3-4.xml

Zeitschrift für Naturforschung BZeitschrift für Naturforschung B

Short microwave-assisted modular synthesis of naturally occurring oxygenated bibenzyls. Krauss, Jürgen / Kopp, Ursula / Bracher ...
more infohttps://www.degruyter.com/view/j/znb.2015.70.issue-9/issue-files/znb.2015.70.issue-9.xml

Asakawa Y[au] - PubMed - NCBIAsakawa Y[au] - PubMed - NCBI

Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis.. Anchang KY, Novakovic M, Bukvicki D, Asakawa Y. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Asakawa+Y%5Bau%5D&dispmax=50

Molecules | Free Full-Text | Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their...Molecules | Free Full-Text | Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their...

Terpenoids and Bibenzyls from Three Argentine Liverworts. Choose your preferred view mode. Please select whether you prefer to ...
more infohttps://www.mdpi.com/1420-3049/16/12/10479

Dihydrostilbenoid - WikipediaDihydrostilbenoid - Wikipedia

Bis(bibenzyls) and macrocyclic bis(benzyls) can be found in bryophytes, such as the compounds plagiochin E, 13,13-O- ... Prenylated bibenzyls can be isolated from the New Zealand liverwort Marsupidium epiphytum or from Radula kojana. One unique ... doi:10.1016/S0031-9422(96)00387-1. Guo, H; Xing, J; Xie, C; Qu, J; Gao, Y; Lou, H (2007). "Study of bis(bibenzyls) in ... Bibenzyls (3,4-dihydroxy-5,5-dimethoxybibenzyl, 3,3-dihydroxy-5-methoxybibenzyl (batatasin III)) can be found in the orchid ...
more infohttps://en.wikipedia.org/wiki/Dihydrostilbenoid

Frontiers | The Origin and Evolution of Plant Flavonoid Metabolism | Plant ScienceFrontiers | The Origin and Evolution of Plant Flavonoid Metabolism | Plant Science

Asakawa, Y., Toyota, M., and Takemoto, T. (1978). 7 new bibenzyls and a dihydrochalcone from radula-variabilis. Phytochemistry ...
more infohttps://www.frontiersin.org/articles/10.3389/fpls.2019.00943/full

KAKEN - Research Projects | DEVELOPMENT OF MEDICINAL DRUGS FROM SOUTHERN HEMISPHERIC TASTY BRYOPHYTES AND FERNS AND THEIR...KAKEN - Research Projects | DEVELOPMENT OF MEDICINAL DRUGS FROM SOUTHERN HEMISPHERIC TASTY BRYOPHYTES AND FERNS AND THEIR...

Journal Article] Bis(bibenzyls)from liverworts inhibit lipopolysacchariade-inducible NOS in RAW 264.7 cells : a study of ... Journal Article] Bis(bibenzyls)from liverworts inhibit lipopolysacchariade-inducible NOS in RAW 264.7 cells : a study of ... Journal Article] Chemical constituents of Malagasy liverworts, Part V : Prenyl bibenzyls and clerodane diterpenoids with nitric ... Journal Article] Chemical constituents of Malagasy liverworts, Part V : Prenyl bibenzyls and clerodane diterpenoids with nitric ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14403014/

Marsupidium epiphytum - WikipediaMarsupidium epiphytum - Wikipedia

Prenylated bibenzyls can be isolated from M. epiphytum. Marsupidium epiphytum on Te Papa New Zealands national museum website ... Toyota, Masao; Omatsu, Ikuko; Braggins, John; Asakawa, Yoshinori (2011). "Novel Prenyl Bibenzyls from the New Zealand Liverwort ...
more infohttps://en.wikipedia.org/wiki/Marsupidium_epiphytum

Bulletin of the Chemical Society of JapanBulletin of the Chemical Society of Japan

Syntheses of Bibenzyls, Olefins, and Related Compounds. Hiroyuki Higuchi, Tetsuo Otsubo, Fumio Ogura, Hachiro Yamaguchi, Yoshi ... Selenides and diselenides bound with an active methylene group like benzyl gave a variety of substituted bibenzyls and related ...
more infohttps://www.jstage.jst.go.jp/browse/bcsj/55/1/_contents/-char/en

Liva Rakotondraibe | Ohio State University College of PharmacyLiva Rakotondraibe | Ohio State University College of Pharmacy

Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: A study of structure- ... Liva Harinantenaina, Dang Ngoc Quang, T. Nishizawa, K. Soma, Y. Asakawa Bis(bibenzyls) from liverworts inhibit LPS induced iNOS ... Chemical Constituents of Malagasy Liverworts, Part V: Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory ... Chemical constituents of malagasy liverworts, Part V: Prenyl bibenzyls and clerodane diterpenoids with nitric oxide inhibitory ...
more infohttps://pharmacy.osu.edu/directory/liva-rakotondraibe

Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in RatsEffect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats

24] had quantified bibenzyls, phenanthrenes, and flavanones, which are used for plant identification among the Dendrobium ...
more infohttps://www.hindawi.com/journals/ecam/2016/1213090/

Cadinene | Article about cadinene by The Free DictionaryCadinene | Article about cadinene by The Free Dictionary

New Alloaromadendrane, Cadinene and Cyclocopacamphane Type Sesquiterpene Derivatives and Bibenzyls from Dendrobium nobile.. ...
more infohttp://encyclopedia2.thefreedictionary.com/cadinene

Bamboo orchid, Arundina graminifolia  : Philippine Medicinal Herbs / StuartXchangeBamboo orchid, Arundina graminifolia : Philippine Medicinal Herbs / StuartXchange

Pharmacologic evaluation showed the bibenzyls possessed remarkable anti-tumor activity in vitro. A new antidepressant ...
more infohttp://stuartxchange.com/BambooOrchid

Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen SpeciesMoscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species

P. Chanvorachote, A. Kowitdamrong, T. Ruanghirun et al., "Anti-metastatic activities of bibenzyls from Dendrobium pulchellum," ...
more infohttps://www.hindawi.com/journals/bmri/2013/765894/

CiNii Articles - MORI TakashiCiNii Articles - MORI Takashi

Total Syntheses of Plagiochins A and D, Macrocyclic Bis(bibenzyls), by Pd(0) Catalyzed Intramolecular Stille-Kelly Reaction ( ...
more infohttps://ci.nii.ac.jp/author?q=MORI+Takashi

KAKEN - Researchers | ASAKAWA Yoshinori (50033874)KAKEN - Researchers | ASAKAWA Yoshinori (50033874)

Bibenzyls / ビスビベンジル類 / Monoterpenes / 薬用植物 / 苔類の辛味成分 / トリテルペン / 抗メラノーマ / 生理活性テルペノイド / キリシマゴケ / bis-bibenzyls / LS-MS / 微生物変換 / ... Presentation] Several Novel Biological Activities of Macrocyclic Bis(bibenzyls)from Liverworts2009. *. Author(s). 橋本敏弘, 浅川義範 ... Journal Article] Marchantiophyta (Liverworts) : Rich sources of macrocyclic bis(bibenzyls).2008. *. Author(s). Asakawa, Y., ... Presentation] Distribution of volatile bibenzyls and tocopherols in liverworts
more infohttps://nrid.nii.ac.jp/en/nrid/1000050033874/

Hsin-Yi Hung - Research Output
     - National Cheng Kung UniversityHsin-Yi Hung - Research Output - National Cheng Kung University

Wang, M. J., Liu, Y. Q., Chang, L. C., Wang, C. Y., Zhao, Y. L., Zhao, X. B., Qian, K., Nan, X., Yang, L., Yang, X. M., Hung, H. Y., Yang, J. S., Kuo, D. H., Goto, M., Morris-Natschke, S. L., Pan, S. L., Teng, C. M., Kuo, S. C., Wu, T. S., Wu, Y. C. & 1 others, Lee, K. H., 2014 Jul 24, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.. Research output: Contribution to journal › Article ...
more infohttps://researchoutput.ncku.edu.tw/en/persons/hsin-yi-hung/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

CiNii Articles - Takahara YusukeCiNii Articles - Takahara Yusuke

Chemical Constituents of Malagasy Liverworts, Part V : Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory ...
more infohttps://ci.nii.ac.jp/author?q=Takahara+Yusuke

CCCC 1970, Volume 35, Issue 6, Abstracts pp. 1926-1929, Cited by

 | Collection of Czechoslovak Chemical CommunicationsCCCC 1970, Volume 35, Issue 6, Abstracts pp. 1926-1929, Cited by | Collection of Czechoslovak Chemical Communications

Asakawa Yoshinori, Toyota Masao, Takemoto Tsunematsu: Seven new bibenzyls and a dihydrochalcone from Radula variabilis. ... Asakawa Yoshinori, Tanikawa Kazuaki, Aratani Takaaki: New substituted bibenzyls of Frullania brittoniae subsp. Truncatifolia. ...
more infohttp://cccc.uochb.cas.cz/35/6/1926/cited_by/

Chemistry of Southeast Asian plants | ScholarBank@NUSChemistry of Southeast Asian plants | [email protected]

... one chemotype can produce bis bibenzyls (type I a?? collected in Singapore), while the other one does not have that capability ... type II a?? collected in Vietnam). This is the first report of the isolation of bis bibenzyls in the family Pallaviciniaceae. ...
more infohttp://scholarbank.nus.edu.sg/handle/10635/15039

Botany 2004 - Abstract SearchBotany 2004 - Abstract Search

bibenzyls. oil bodies. 879. An ultrastructural overview of adaptations that make dodders (Cuscuta spp.) efficient parasites. ...
more infohttp://2004.botanyconference.org/engine/search/index.php?func=AbstractTitle

Botany 2004 - Abstract SearchBotany 2004 - Abstract Search

bibenzyls. oil bodies. 32-8. Special Event Center (Cliff Lodge). Spatial Patterns of Species Richness of Mosses in Southern New ...
more infohttp://www.2004.botanyconference.org/engine/search/index.php?func=datetime&date=2004-08-03&time=12:30:00

Subject: countercurrent chromatography / Journal: Journal of separation science / Subject: nuclear magnetic resonance...Subject: 'countercurrent chromatography' / Journal: Journal of separation science / Subject: nuclear magnetic resonance...

Separation and purification of 9,10‐dihydrophenanthrenes and bibenzyls from Pholidota chinensis by high‐speed countercurrent ... bibenzyls and 9,10‐dihydrophenanthrenes, on a preparative scale from whole plants of P. chinensis with different solvent ...
more infohttps://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Journal+of+separation+science&f%5Bsubject_term%5D%5B%5D=nuclear+magnetic+resonance+spectroscopy&f%5Bsubject_term%5D%5B%5D=methanol&per_page=50&q=%22countercurrent+chromatography%22&search_field=subject

Author: Guan, Shu-Hong - PubAg Search ResultsAuthor: 'Guan, Shu-Hong' - PubAg Search Results

Phenanthrenes, 9,10-dihydrophenanthrenes, bibenzyls with their derivatives, and malate or tartrate benzyl ester glucosides from ... five bibenzyls, seven malate or tartrate benzyl ester glucosides, adenosine and gastrodin were isolated from tubers of ...
more infohttps://pubag.nal.usda.gov/?q=%22Guan%2C+Shu-Hong%22&search_field=author

リンクリンク

9. In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from the liverworts against Trypanosoma brucei. Otoguro ... Novel prenyl bibenzyls from the New Zealand liverwort Marsupidium epiphytum. M. Toyota, I. Omatsu, J. Braggins and Y. Asakawa, ... Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids from Indonesian, Tahitian and Japanese liverworts. ... Distribution of cyclic and acyclic bis-bibenzyls in the Marchantiophyta (liverworts), ferns and higher plants and their ...
more infohttp://p.bunri-u.ac.jp/lab23/report/report.htm
  • Balantiopsis rosea produced quite interesting 1-cyclohexy1-2-phenyl ethane derivatives which were suggested to be the biosynthetic precursors of the typical bibenzyls and … More bisbibinzyls which were peculiar secondary metabolites of liverworts. (nii.ac.jp)
  • 9. In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from the liverworts against Trypanosoma brucei. (bunri-u.ac.jp)
  • 10. Distribution of cyclic and acyclic bis-bibenzyls in the Marchantiophyta (liverworts), ferns and higher plants and their biological activity, biosynthesis, and total synthesis. (bunri-u.ac.jp)
  • Bis(bibenzyls) and macrocyclic bis(benzyls) can be found in bryophytes, such as the compounds plagiochin E, 13,13'-O-isoproylidenericcardin D, riccardin H, marchantin E, neomarchantin A, marchantin A and marchantin B in the Chinese liverwort Marchantia polymorpha. (wikipedia.org)
  • Asakawa Yoshinori, Tanikawa Kazuaki, Aratani Takaaki: New substituted bibenzyls of Frullania brittoniae subsp. (cas.cz)