Compounds with 1,2-diphenylethane. They are structurally like reduced STILBENES.
A plant division. They are simple plants that lack vascular tissue and possess rudimentary rootlike organs (rhizoids). Like MOSSES, liverworts have alternation of generations between haploid gamete-bearing forms (gametophytes) and diploid spore-bearing forms (sporophytes).
An oil-resistant synthetic rubber made by the polymerization of chloroprene.

Erianin induces apoptosis in human leukemia HL-60 cells. (1/44)

AIM: To investigate the effect of erianin on human HL-60 cell line and explore its mechanism of apoptosis in vitro. METHODS: Inhibition of proliferation was measured with colorimetric MTT assay. The morphologic changes were observed by fluorescence and electron microscopes. DNA fragmentation was visualized by agarose gel electrophoresis, and the DNA degradation was determined by flow cytometry. Immunohistochemical analysis was used to identify the expression of bcl-2 and bax genes. RESULTS: The growth of human HL-60 cells was significantly inhibited by erianin 20-81.9 nmol/L during 72 h treatment (P < 0.01). The IC50 value was 38 nmol/L after a 24-h exposure to erianin, while that of vincristine, the positive control, was 101 nmol/L. The typical morphologic changes were observed and the nuclear DNA fragmentation exhibited "ladder" pattern. The cell cycle of HL-60 cells was arrested in G2/M phase, and expression of bcl-2 gene was decreased while that of bax was increased. CONCLUSION: Erianin showed potent inhibitory activity on the proliferation of HL-60 cells. The inhibition might be relative to the apoptosis induced by erianin and the altered expression of bcl-2 and bax genes in HL-60 cells.  (+info)

The biology of the combretastatins as tumour vascular targeting agents. (2/44)

The tumour vasculature is an attractive target for therapy. Combretastatin A-4 (CA-4) and A-1 (CA-1) are tubulin binding agents, structurally related to colchicine, which induce vascular-mediated tumour necrosis in animal models. CA-1 and CA-4 were isolated from the African bush willow, Combretum caffrum, and several synthetic analogues are also now available, such as the Aventis Pharma compound, AVE8062. More soluble, phosphated, forms of CA-4 (CA-4-P) and CA-1 (CA-1-P) are commonly used for in vitro and in vivo studies. These are cleaved to the natural forms by endogenous phosphatases and are taken up into cells. The lead compound, CA-4-P, is currently in clinical trial as a tumour vascular targeting agent. In animal models, CA-4-P causes a prolonged and extensive shut-down of blood flow in established tumour blood vessels, with much less effect in normal tissues. This paper reviews the current understanding of the mechanism of action of the combretastatins and their therapeutic potential.  (+info)

New bibenzyl cannabinoid from the New Zealand liverwort Radula marginata. (3/44)

The ether extract of the New Zealand liverwort Radula marginata afforded a new cannabinoid type bibenzyl compound named perrottetinenic acid, and two new bibenzyls, together with a known cannabinoid, perrottetinene. Their structures were established by two dimensional (2D) NMR spectral data. The structure of perrottetinenic acid was a similar to that of Delta(1)-tetrahydrocannabinol, a known hallucinogen. Cannabinoid type bibenzyls have been isolated from liverwort Radula perrottetii, though have not previously been reported from the liverwort R. marginata.  (+info)

Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. (4/44)

PURPOSE: A phase I trial was performed with combretastatin A4 phosphate (CA4P), a novel tubulin-binding agent that has been shown to rapidly reduce blood flow in animal tumors. PATIENTS AND METHODS: The drug was delivered by a 10-minute weekly infusion for 3 weeks followed by a week gap, with intrapatient dose escalation. Dose escalation was accomplished by doubling until grade 2 toxicity was seen. The starting dose was 5 mg/m2. RESULTS: Thirty-four patients received 167 infusions. CA4P was rapidly converted to the active combretastatin A4 (CA4), which was further metabolized to the glucuronide. CA4 area under the curve (AUC) increased from 0.169 at 5 mg/m2 to 3.29 micromol * h/L at 114 mg/m2. The mean CA4 AUC in eight patients at 68 mg/m2 was 2.33 micromol * h/L compared with 5.8 micromol * h/L at 25 mg/kg (the lowest effective dose) in the mouse. The only toxicity that possibly was related to the drug dose up to 40 mg/m2 was tumor pain. Dose-limiting toxicity was reversible ataxia at 114 mg/m2, vasovagal syncope and motor neuropathy at 88 mg/m2, and fatal ischemia in previously irradiated bowel at 52 mg/m2. Other drug-related grade 2 or higher toxicities seen in more than one patient were pain, lymphopenia, fatigue, anemia, diarrhea, hypertension, hypotension, vomiting, visual disturbance, and dyspnea. One patient at 68 mg/m2 had improvement in liver metastases of adrenocortical carcinoma. CONCLUSION: CA4P was well tolerated in 14 of 16 patients at 52 or 68 mg/m2; these are doses at which tumor blood flow reduction has been recorded.  (+info)

Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate. (5/44)

PURPOSE: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical trials, but recent preclinical studies have shown that CA1P displays a greater antitumor effect than the combretastatin A4 (CA4) analog at equal doses. The aim of this study, therefore, is to compare pharmacokinetics and metabolism of the two compounds to determine whether pharmacokinetics plays a role in their differential activity. EXPERIMENTAL DESIGN: NMRI mice bearing MAC29 tumors received injection with either CA4P or CA1P at a therapeutic dose of 150 mg x kg(-1), and profiles of both compounds and their metabolites analyzed by a sensitive and specific liquid chromatography/mass spectroscopy method. RESULTS: The metabolic profile of both compounds is complex, with up to 14 metabolites being detected for combretastatin A1 (CA1) in the plasma. Many of these metabolites have been identified by liquid chromatography/mass spectroscopy. Initial studies, however, focused on the active components CA4 and CA1, where plasma and tumor areas under the curve were 18.4 and 60.1 microg x h x ml(-1) for CA4, and 10.4 and 13.1 microg x h x ml(-1) for CA1, respectively. In vitro metabolic comparisons of the two compounds strongly suggest that CA1 is metabolized to a more reactive species than the CA4. CONCLUSIONS: Although in vitro studies suggest that variable rates of tumor-specific prodrug dephosphorylation may explain these differences in pharmacokinetics profiles, the improved antitumor activity and altered pharmacokinetic profile of CA1 may be due to the formation of a more reactive metabolite.  (+info)

Erianin induces a JNK/SAPK-dependent metabolic inhibition in human umbilical vein endothelial cells. (6/44)

BACKGROUND: Erianin is a natural product derived from Dendrobium chrysotoxum, with promising antitumor activity. MATERIALS AND METHODS: To evaluate the metabolic effect of erianin, a cytosensor assay for acidification rate, MTT assay, measurement of lactate, glucose and ATP were performed in human umbilical vein endothelial cells (HUVECs) exposed to 1-100 nM erianin. JNK/SAPK activity was detected by Western blot. RESULTS: Twelve- or 24- hour incubation with erianin induced a dose-dependent metabolic inhibition, as indicated by reduced acidification rate and cell viability, with an endothelium-selectivity. Erianin caused decreases in lactate production, glucose consumption and intracellular ATP level. Pretreatment with the JNK/SAPK inhibitor SP600125 significantly abolished these inhibitory responses, and especially restored the erianin-induced decreases in ATP and the erianin-induced phosphorylation of JNK/SAPK with dose- and time- dependence. CONCLUSION: Erianin inhibited endothelial metabolism in a JNK/SAPK-dependent manner. This mechanism may be involved in the potential antitumnor and antiangiogenic actions of erianin.  (+info)

A dual-color fluorescence imaging-based system for the dissection of antiangiogenic and chemotherapeutic activity of molecules. (7/44)

We have developed a simple yet sensitive dual color fluorescence-based technique for dissecting the tumor-neovascularization relationship and evaluated the susceptibility of each component to therapeutic interventions. Green fluorescent protein (GFP)-expressing melanoma cells were cocultured with endothelial cells on different three-dimensional (3-D) matrices and exposed to multiple growth factors and molecules with established anti-angiogenic or anticancer activities. Cells were fixed and stained with propidium iodide, imaged using a confocal microscope, and stereologically analyzed. Three-dimensionality of the system was tested by depth-coding and pseudocolor 3-D reconstruction in the z-axis. Selective ablation of the tumor cells was affected by the anthracycline antibiotic doxorubicin. Treatment with vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) promoted the neovascular responses on matrigel and collagen-1 matrices. VEGF-induced angiogenesis was inhibited after treatment with combretastatin and thalidomide. In contrast, HGF exerted a protective effect against these anti-angiogenics in a matrigel matrix. However, this effect was lost when the matrix was substituted with collagen, suggesting that the extracellular matrix impinges on cellular function, possibly through an Akt-mediated mechanism. The VEGF-receptor antagonist PTK787 also selectively ablated the VEGF-induced angiogenic effect without inhibiting the HGF-induced response, demonstrating the sensitivity of the system to detect modulation of distinct signal cascades. The current model encompasses the possibility of studying tumor-angiogenesis-matrix interaction on the same platform, expanding the rapid screening of novel molecules in a simulated clinicopathological setting.  (+info)

Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. (8/44)

In the continuing search for effective treatments for cancer, the emerging model is the combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood vessel growth. However, the implementation of this strategy has faced two major obstacles. First, the long-term shutdown of tumour blood vessels by the anti-angiogenesis agent can prevent the tumour from receiving a therapeutic concentration of the chemotherapy agent. Second, inhibiting blood supply drives the intra-tumoural accumulation of hypoxia-inducible factor-1alpha (HIF1-alpha); overexpression of HIF1-alpha is correlated with increased tumour invasiveness and resistance to chemotherapy. Here we report the disease-driven engineering of a drug delivery system, a 'nanocell', which overcomes these barriers unique to solid tumours. The nanocell comprises a nuclear nanoparticle within an extranuclear pegylated-lipid envelope, and is preferentially taken up by the tumour. The nanocell enables a temporal release of two drugs: the outer envelope first releases an anti-angiogenesis agent, causing a vascular shutdown; the inner nanoparticle, which is trapped inside the tumour, then releases a chemotherapy agent. This focal release within a tumour results in improved therapeutic index with reduced toxicity. The technology can be extended to additional agents, so as to target multiple signalling pathways or distinct tumour compartments, enabling the model of an 'integrative' approach in cancer therapy.  (+info)

0060] Pharmaceutically acceptable prodrugs of the compounds of formula (I), (II) or (III) are derivatives which have chemically or metabolically cleavable groups and become, by solvolysis or under physiological conditions, the compounds of the present invention which are pharmaceutically active in vivo. Prodrugs of the compounds of formula (I), (II) or (III) may be formed in a conventional manner with a functional group of the compounds such as with an amino or a hydroxyl group. The prodrug derivative form often offers advantages of solubility, tissue compatibility or delayed release in a mammalian organism (see, Bundgaard, H., Design of Prodrugs, pp. 7-9, 21-24, Elsevier, Amsterdam 1985). When a compound employed in the present invention has a hydroxyl group, an acyloxy derivative prepared by reacting the hydroxyl group with a suitable acylhalide or a suitable acid anhydride is exemplified as a prodrug. An especially preferred acyloxy derivative as a prodrug is --OC(═O)--CH3, ...
Zybrestat (combretastatin A4 phosphate) is a prodrug that is converted to combretastatin inside the endothelial cells that line blood vessels. Combretastatin has a dual-mode of action, targeting both VE-cadherin, a junction protein that is important for endothelial cell survival, and the associated beta-catenin/AKT signalling pathway.. Once activated within the endothelial cell, it causes rapid collapse and necrosis of the tumours vascular structure.. As a reversible tubulin depolymerizing agent, combretastatin also causes tumour-associated endothelial cells to change from a flat to a round shape. This has the effect of plugging the blood vessels so depriving the tumour of the oxygen and nutrients it needs to survive.. Because the endothelial cells of tumours are immature they are much more sensitive to the effects of combretastatin than the endothelial cells of normal tissue.. ...
Members of the combretastatin family possess varying ability to cause vascular disruption in tumors. Combretastatin binds to the β-subunit of tubulin at what is called the colchicine site, referring to the previously discovered vascular disrupting agent colchicine. Inhibition of tubulin polymerization prevents cancer cells from producing microtubules. Microtubules are essential to cytoskeleton production, intercellular movement, cell movement, and formation of the mitotic spindle used in chromosome segregation and cellular division. The anti-cancer activity from this action results from a change in shape in vasculature endothelial cells. Endothelial cells treated with combretastatin rapidly balloon in shape causing a variety of effects which result in necrosis of the tumor core. The tumor edge is supported by normal vasculature and remains, for the most part, unaffected. As a result it is likely that any therapeutic use will involve a combination of drugs or treatment options. ...
REVERSAL OF PARALYSIS IN MODELS OF ALZHEIMER´S DISEASE Age-progressive neurodegenerative pathologies, including AD, are distinguished and diagnosed by disease-specific components of intra- or extracellular aggregates. A combretastatin analog, PNR502, can prevent and even reverse AD-like protein aggregation and associated functional/behavioral declines in C.elegans models of Ab1-42-induced amyloid deposition. Read More!. ESCAPE AND FREEZE RESPONSE TO ABIOTIC STRESS Thermal, osmotic, oxidative and hypoxic stress cause specific short and long term responses in C.elegans. Using WMicrotracker system is possible to study the dynamics of behavioral response to stress in real time and measure the effect of new small molecules, genes or natural compounds. Below we present an example of application with Thermal stress. More info!. ...
About ZYBRESTAT (fosbretabulin) ZYBRESTAT is being evaluated in a Phase 2 study of patients with NSCLC and other clinical trials. OXiGENE believes that ZYBRESTAT is poised to become an important product in a novel class of small-molecule drug candidates called vascular disrupting agents (VDAs). Through interaction with vascular endothelial cell cytoskeletal proteins, ZYBRESTAT selectively targets and collapses tumor vasculature, thereby depriving the tumor of oxygen and nutrients, causing death of tumor cells. In clinical trials in solid tumors, ZYBRESTAT has demonstrated potent and selective activity against tumor vasculature, as well as clinical activity against ATC, ovarian cancer and various other solid tumors. About OXiGENE OXiGENE is a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases. The Companys major focus is developing vascular disrupting agents (VDAs) that selectively disrupt abnormal blood vessels associated with solid tumor ...
Members of OXiGENEs management team will review first quarter results via a webcast and conference call today at 2:00 p.m. EDT (11:00 a.m. PDT). To listen to a live or an archived version of the audio webcast, please log on to the Companys website, www.oxigene.com. Under the Investor Center tab, select the link to Presentations & Conference Calls.. OXiGENEs earnings conference call can also be heard live by dialing (888) 208-1507 in the United States and Canada, and (913) 312-0402 for international callers, five minutes prior to the beginning of the call. A replay will be available starting at 5:00 p.m. EDT (2:00 p.m. PDT) on August 4, 2008 and ending at 5:00 p.m. EDT (2:00 p.m. PDT) on Monday, August 11, 2008. To access the replay, please dial (888) 203-1112 if calling from the United States or Canada, or (719) 457-0820 from international locations. Please refer to replay pass code 6113741. About ZYBRESTAT (fosbretabulin) ZYBRESTAT is currently being evaluated in a pivotal registration ...
TY - CHAP. T1 - Anthracycline, Trastuzumab, and Cardiovascular Toxicity. AU - Cochran, T. R.. AU - Franco, V. I.. AU - Scully, R.. AU - Lipshultz, S. E.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - In cancer treatment, the pervasive late effects of radiation and chemotherapy limit their utility, especially in children, in whom treatment often leads to lifelong morbidity and excess mortality. Advances in understanding the molecular pathways related to tumorigenesis have led to the development of targeted therapies, but recurrent late effects, as in the case of trastuzumab, and unexpectedly high rates of cardiotoxicity highlight gaps in our understanding of drug pathways and the mechanisms of treatment toxicity. Here, we review the mechanisms of anthracycline activity in tumor and cardiac cells, as well as the clinical manifestations and their associated cardiotoxicity, prevention strategies, and monitoring recommendations. We also describe the cardiac effects of trastuzumab with specific attention to its ...
Re: [dts] [PATCH V2]tests/shutdown_api: fix cant create vf 2020-03-20 8:37 [dts] [PATCH V2]tests/shutdown_api: fix cant create vf Zeng Xiaoxiao 2020-03-20 9:02 ` Zeng, XiaoxiaoX @ 2020-03-24 6:51 ` Tu, Lijuan 1 sibling, 0 replies; 4+ messages in thread From: Tu, Lijuan @ 2020-03-24 6:51 UTC (permalink / raw) To: Zeng, XiaoxiaoX, dts; +Cc: Zeng, XiaoxiaoX Applied, thanks , -----Original Message----- , From: dts [mailto:[email protected]] On Behalf Of Zeng Xiaoxiao , Sent: Friday, March 20, 2020 4:38 PM , To: [email protected] , Cc: Zeng, XiaoxiaoX ,[email protected], , Subject: [dts] [PATCH V2]tests/shutdown_api: fix cant create vf , , Signed-off-by: Zeng Xiaoxiao ,[email protected], , --- , tests/TestSuite_shutdown_api.py , 6 +++++- , 1 file changed, 5 insertions(+), 1 deletion(-) , , diff --git a/tests/TestSuite_shutdown_api.py , b/tests/TestSuite_shutdown_api.py index 11d451b..8699e79 100644 , --- a/tests/TestSuite_shutdown_api.py , +++ b/tests/TestSuite_shutdown_api.py , @@ ...
After the 4CA update, my LG G3, which has been rock solid, has started to shutdown, and getting it going again is very difficult. Is anyone else
From the stem bark of Salacia chinensis L. collected in Vietnam, eight triterpenoids were isolated, including one new natural product.Phytochemical studies has shown that the liverwort Pallavicinia lyellii may have two chemotypes: one chemotype can produce bis bibenzyls (type I a?? collected in Singapore), while the other one does not have that capability (type II a?? collected in Vietnam). This is the first report of the isolation of bis bibenzyls in the family Pallaviciniaceae. Both chemotypes, however, biosynthesized a number of complex modified labdane diterpenoids. Type II P. lyellii can produce Diels-Alder cycloaddition type dimeric diterpenoids. This is also the first report of 2-oxygenated labdane diterpenoid in liverworts.Bioassays screening for nociceptin receptor (NOP) ligand revealed that the crude extract of the Vietnamese P. lyellii has higher binding affinity to NOP than the endogenous ligand OFQ/N. Further investigation is needed in order to identify the potential NOP ligand from ...
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue.
Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery systems. However, a major drawback remains its toxicity to healthy tissue and the development of multi-drug resistance during prolonged treatment. This is why in our work we aimed to improve DOX delivery and reduce the toxicity by chemical conjugation with a new nanoplatform based on polymalic acid. For delivery into recipient cancer cells, DOX was conjugated via pH-sensitive hydrazone linkage along with polyethylene glycol (PEG) to a biodegradable, non-toxic and non-immunogenic nanoconjugate platform: poly(β-L-malic acid) (PMLA). DOX-nanoconjugates were found stable under physiological conditions and shown to successfully inhibit in vitro cancer cell growth of several invasive breast carcinoma cell lines such as MDA-MB-231 and MDA-MB- 468 and of primary glioma cell lines such as U87MG and U251.
Presumably, progression of developmental retinal vascular disorders is mainly driven by persistent ischemia/hypoxia. An investigation into vision-threatening retinal ischemia remains important. Our aim was to evaluate, in relation to retinal ischemia, protective effects and mechanisms of Dendrobium nobile Lindley (DNL) and its bibenzyl component moscatilin. The therapeutic mechanisms included evaluations of levels of placental growth factor (PLGF) and Norrie disease protein (NDP). An oxygen glucose deprivation (OGD) model involved cells cultured in DMEM containing 1% O2, 94% N2 and 0 g/L glucose. High intraocular pressure (HIOP)-induced retinal ischemia was created by increasing IOP to 120 mmHg for 60 min in Wistar rats. The methods included electroretinogram (ERG), histopathology, MTT assay and biochemistry. When compared with cells cultured in DMEM containing DMSO (DMSO+DMEM), cells subjected to OGD and pre-administrated with DMSO (DMSO+OGD) showed a significant reduction in the cell viability and NDP
Show more ,Combretastatin A-4 and isocombretastatin A-4 derivatives having thiophenes or benzo[b]thiophenes instead of the B ring were prepared and evaluated for their in cellulo tubulin polymerization inhibition (TPI) and antiproliferative activities. The presence of the benzo[b]thiophene ring proved to have a crucial effect as most of the thiophene derivatives, except those having one methoxy group, were inactive to inhibit tubulin polymerization into microtubules. The influence of the attachment position was also studied: benzo[b]thiophenes having iso or cis 3,4,5-trimethoxystyrenes at position 2 were 12-30-fold more active than the 3-regioisomers for the TPI activity. Some of the novel designed compounds exhibited interesting anti-proliferative effects on two different cell lines.Show less , ...
A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg-Backlund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg-Backlund approach has also been extended to prepare the (E)-stilbene DMU-212, which also possesses interesting growth inhibitory properties. ...
TY - JOUR. T1 - Cardiovascular toxicities associated with immune checkpoint inhibitors. AU - Hu, Jiun Ruey. AU - Florido, Roberta. AU - Lipson, Evan. AU - Naidoo, Jarushka. AU - Ardehali, Reza. AU - Tocchetti, Carlo G.. AU - Lyon, Alexander R.. AU - Padera, Robert F.. AU - Johnson, Douglas B.. AU - Moslehi, Javid. PY - 2019/4/15. Y1 - 2019/4/15. N2 - Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in case series but have been underappreciated due to their recent emergence, difficulties in diagnosis and non-specific clinical manifestations. ICIs are antibodies that block negative regulators of the T cell immune response, including cytotoxic T lymphocyte-associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and PD-1 ligand (PD-L1). While ICIs have introduced a significant mortality benefit in several cancer types, the augmented immune response has led to a range of immune-related toxicities, including cardiovascular toxicity. ...
Vincent L,Kermani P,Young LM,Cheng J,Zhang F,Shido K,Lam G,Bompais-Vincent H,Zhu Z,Hicklin DJ,Bohlen P,Chaplin DJ, et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest 2005; 115: 2992-3006 ...
and mean vessel diameter R. The pre- and posttreatment histogram shapes of R are in qualitative agreement with those obtained in our study supporting a common mechanism of action for the 2 tubulin-binding agents. The peak in the histogram for pretreatment R occurs at a slightly higher vessel size in our study, which may be attributed to scaling problems as addressed later, and while the increases in median and upper quartile of R in our study were not significant, they found significant reductions in percentiles at 60% and below. Our finding is also in agreement with intravital microscopy data on CA4P activity showing that reduction in venule number is largest for small venules (diameter , 10 μm), and that reduction in arteriolar diameter occurs (11). The distribution of R in the current study may reflect the combination of these vascular effects. The reduction in vessels with radii in the interval (≈20-30 μm) could reflect the reported reduction in small venules. As the number of vessels ...
J. E. Heavner, C. F. Dryden, V. Sanghani, G. Huemer, A. Bessire, J. M. Badgwell; Severe Hypoxia Enhances Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Lightly Anesthetized Pigs. Anesthesiology 1992;77(1):142-147. Download citation file:. ...
Anggrek hybrid ini merupakan silangan Bpk. Atmo Kolopaking, yang diregister pada 01 Januari 1975. Hasil silangan antara Dendrobium metasari mustika (seed parent) x Dendrobium anosmum (pollen parent). Catatan : ...
Binding agents with differential activity can be provided, whereby certain activities of a first part of the binding agent are reduced or prevented until binding to a target occurs. This is useful if the binding agent is intended to bind both an effector cell and a target to be destroyed, because the effector cell can be protected from significant cell damage that might otherwise occur (e.g. due to premature activation of complement and/or ADCC). Such binding agents are useful in the treatment of cancer, for example.
Dendrobium antennatum - Flowering size,, Pot-grown plant, Plant size ca. 30cm, Flower size ca. 4 - 5cm, Semishade to sunny, Moderately damp, Temperate, May - September, No rest period
On offer is a new release seedling of the Australian Native Dendrobium Anthedon Star (= schoeninum x calamiforme) growing in a 40mm pot. This is a combination of two Aussie species, with D. calamiforme being a close relative to D. teretifolium, but with its distribution being from North Eastern Queensland. D. calamiforme is distinct in […]
Université de Liège - ULg , Département clinique des animaux de compagnie et des équidés , Département clinique des animaux de compagnie et des équidés ,] ...
SHUTDOWN(); -- Shut down the current impalad with the default deadline. :SHUTDOWN(hostname); -- Shut down impalad running on hostname with the default deadline. :SHUTDOWN(\hostname:1234\); -- Shut down impalad running on host at port 1234 with the default deadline. :SHUTDOWN(10); - Shut down the current impalad after 10 seconds. :SHUTDOWN(hostname, 10); - Shut down impalad running on hostname when all queries running on hostname finish, or after 10 seconds. :SHUTDOWN(hostname:11, 10 * 60); -- Shut down impalad running on hostname at port 11 when all queries running on hostname finish, or after 600 seconds. :SHUTDOWN(0); -- Perform an immdediate shutdown of the current impalad ...
Photos, culture and other information, and ordering details for flasks of Dendrobium amethystoglossum MC6415 × sib MC7374
Free Ampare Shutdown Manager Download,Ampare Shutdown Manager 1.2 is A tool lets you manage your computers shutdown, restart or logoff.
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A government shutdown Oct. 1 could stop some federal services, but tax payments will be due on their regular deadlines, including Oct. 15 extensions.
Im seeing mixed results in the field as to whether or not SMC Firmware Update 1.1 actually resolves, once and for all, the Random Shutdown Syndrome (RSS) affec...
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The stilbenic compound (Z)-combretastatin A-4 (CA-4) has been described as a potent tubulin polymerization inhibitor. In vivo, CA-4 binds to tubulin and inhibits microtubule depolymerization, which results in morphological changes in proliferating endothelial cells. Combretastatin A-4 prodrug phosphate is a leading vascular disrupting agent and is currently being evaluated in multiple clinical trials as a treatment for solid tumors. The aim of this study was to identify and characterize the UDP-glucuronosyltransferase (UGT) isoforms involved in CA-4 glucuronidation by incubation with human liver microsomes and a panel of nine liver-expressed recombinant UGT Supersomes (1A1, 1A3, 1A4, 1A6, 1A9, 2B4, 2B7, 2B15, and 2B17). As we observed, the high rate of formation of CA-4 glucuronide (Vmax = 12.78 ± 0.29 nmol/min/mg protein) and the low Km (6.98 ± 0.65 μM) denoted that UGT1A9 was primarily responsible for the in vitro glucuronidation of CA-4. UGT1A6 was also a significant contributor to CA-4 ...
Dendrobium orchids comprise the largest and most diverse catch-all orchid genus. It almost seems that whenever taxonomists dont know where an orchid belongs, they classify it as Dendrobium. But of course, there is at least some logic to the organization. The over 1,200 Dendrobium species are native to the tropics of Asia and The Pacific. Papua New Guinea alone has more than 500 species. Usually you would find Dendrobium growing in the tops of trees. In fact, the name Dendrobium is Greek for life in a tree.. Dendrobium are so diverse that you could find them growing in tropical lowlands and all the way to an altitude of 10,000 feet (3,000 meters). You could also find them in humid, swampy ground or desert-like environments. As you can imagine, that diversity does not make it easy for me to tell you exactly how to grow your Dendrobium. So youre out of luck.. Just kidding - Ill try. Some species like it hot; some like it cool. Some species are deciduous and require a break from watering, but ...
Natural antioxidants and plant-derived compounds provide a strong defense against cellular damage caused by free-radical induced oxidative stress [16, 17]. Free-radicals and various reactive oxygen species are produced during cellular metabolism in all living systems and are responsible for oxidative cellular damage in human beings. To reduce this damage, some sort of defense mechanism is needed, and indeed, several types of natural and artificial antioxidants are used to control oxidative stress. In particular, plant-derived compounds are a potent source of novel antioxidant activity [18]. Bibenzyl derivatives isolated from D. moniliforme were examined for their antioxidant capacity using DPPH free-radical scavenging assay [11, 13, 14], a popular tool because of its simplicity and high sensitivity. This assay works on the principle that any hydrogen donor is an antioxidant. Thus, a compounds antioxidant effect is proportional to the disappearance of DPPH radicals in test samples [19].. The ...
TY - JOUR. T1 - Cardiovascular toxicity of tyrosine kinase inhibitors. AU - Mouhayar, Elie. AU - Durand, Jean Bernard. AU - Cortes, Jorge. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Introduction: Small-molecule tyrosine kinase inhibitors (TKIs) have revolutionized the management of many malignancies. However, they also have been shown to be associated with a certain degree of cardiovascular side effects that are often reversible. Areas covered: As the number of new TKIs continues to grow, it is expected that clinicians will be facing the challenge of early detection and 10 management of these side effects while balancing the risk-benefit ratios of continuing with life-saving cancer therapy medications. This review will present the current knowledge related to incidence and proposed mechanisms of cardiovascular side effects of TKIs and also discuss treatment recommendations when available Expert opinion: We will present and discuss available data and suggest recommendations related to patient monitoring ...
Dendrobium species, commonly known as Shihu or Huangcao, represents the second largest genus of Orchidaceae, which are used commonly as tonic herbs and healthy food in many Asian countries. The aim of this paper is to review the history, chemistry, and pharmacology of different Dendrobium species on the basis of the latest academic literatures found in Google Scholar, PubMed, Sciencedirect, Scopus, and SID.
How to Cut the Old Stems on a Dendrobium Orchid. Lovely, exotic spray orchids (Dendrobium phalaenopsis) are a tempting purchase when they are in full bloom. The common spray orchid has a two-part stem ranging from 12 to 40 inches long comprising a pseudobulb with leaves on its upper half and a smooth, slender flower ...
Cancer stem cells (CSCs) have been recognized as rare populations driving cancer progression, metastasis, and drug resistance in leading cancers. Attempts have been paid toward identifying compound that specifically targets these CSCs. Therefore, the investigations of the novel therapeutic strategies for CSCs targeting is required. The cytotoxic effects of Chrysotoxine on human NSCLC-derived H460 and H23 cells were tested by MTT assay. The Effect of Chrysotoxine suppresses CSC-like phenotypes was determined in CSC-rich populations and primary CSCs in 3D culture and Extreme limiting dilution assay. Expression of CSC markers and associated proteins were determined by Western blot analyses and flow cytometry. We have reported the CSC-suppressing activity of Chrysotoxine, a bibenzyl compound isolated from Dendrobium pulchellum. We have shown for the first time that Chrysotoxine dramatically suppressed CSC-like phenotypes of human lung cancer H460 and H23 cells. Treatment of Chrysotoxine ...
The Dendrobium orchid genus encompasses approximately 1,200 varieties. A wide range of sizes and flower colors exist. Some varieties sport flowers that last
Global Dendrobium Luminous Pills Market research study report is a respected source of information which offers a telescopic view of the current market sta
Like a mini-conservatory, this simple whiteware square is lushly filled with greens and exotic flowers: two multi-blossomed Dendrobium orchid stems float airily above an ivy and moss ground to bring the beauty of the outdoors inside. Plant lovers will enjoy the harmony and balanced design in this tabletop garden. Add a package of Miracle Gro® Orchid Plant Food Spikes to keep your plant growing and thriving.
To confirm the registration of a Dendrobium hybrid & view its composition/progeny: (Database as at 1 January 2018 RHS registrations). ...
Learn about this Smoking Cessation and Endothelial Dysfunction study at University of California Health (now recruiting people ages 21-39!)
DEar Jeanne, Thank you for this information. I know we and the whole world is waiting and praying for its success. This is in the category of endostatin and angiogenesis that Dr. Judah Volkman has worked so hard to get into trials all these years. We owe him a world of gratitude as well. Thank you Jeanne, God Bless You, marty and Barb Auslander Jeanne Kissinger wrote: , , I am looking for the clinical trial criteria for this trial. No luck yet , and have to go. Lil? Marty? Whoever. I talked to the clinical trials , nurse and she said to get it off the web. I have pulled up quite a list , off alltheweb.com just type in Oxigene, no quotes needed. Jeanne , , http://www.oxigene.com/press/11-5-99.htm , , OXiGENE PRESENTS INTERIM COMBRETASTATIN A4 PRODRUG , PHASE I CLINICAL TRIAL RESULTS , , - New Clinical Data on Anti-Tumor Vascular Targeting Agent Presented , at the Chemotherapy Foundation Symposium - , , Boston, MA and Stockholm, Sweden, November 5, 1999-OXiGENE, Inc. , (Nasdaq: OXGN, SSE: OXGN) ...
Slug radula. Coloured scanning electron micrograph (SEM) of the radula from a red slug (Arion rufus). The radula is a tongue-like organ found in most molluscs. It is studded with rows of horny teeth (grey), which are used to rasp food particles from surfaces. Magnification: x660 when printed at 10 centimetres wide. - Stock Image C020/8738
With over 40 participants from 30 large companies, TOLSON officially marked the beginning of a the 5th VDA cycle.. VDA is a structured peer-to-peer benchmarking initiative on priority topics for Procurement. VDA includes REX on innovative projects by participants, best practice sharing, expert insights, discovery of disruptive solutions, collective initiatives and much more !. Today we have a great community that keeps growing and progressing together by leveraging collective intelligence.. This is why our workstreams are continuously evolving and this year the focus will be on :. ...
liverwort is a plant. people make medicinal drug out of the fresh or dried components that develop above the ground. notwithstanding critical protection...
Orchids make a welcoming and graceful addition to your home. To buy a potted orchid plant or a gorgeous orchid arrangement browse ORCHIDS.COM today.
Time flies so fast... As a new blogger, its hard to believe that I have already made 1,000 posts on my blog. I started blogging on Ju ...
Gentaur molecular products has all kinds of products like :search , Cell Biolabs \ OxiSelect™ Human KIM-1 ELISA Kit \ STA-374 for more molecular products just contact us
To shutdown it I have to explicitly type a shutdown command, and even this way the window dont get closed. I have to close it using Power off the machine ...
The government shutdown is likely to mean an early death for thousands of mice used in research on diseases such as diabetes, cancer and Alzheimer's.
ISBN 0-412-55070-9. Keserű, G. M.; Nógrádi, M. (1995). "The chemistry of macrocyclic bis(bibenzyls)". Natural Product Reports. ...
Bis(bibenzyls) and macrocyclic bis(benzyls) can be found in bryophytes, such as the compounds plagiochin E, 13,13'-O- ... Prenylated bibenzyls can be isolated from the New Zealand liverwort Marsupidium epiphytum or from Radula kojana. One unique ... doi:10.1016/S0031-9422(96)00387-1. Guo, H; Xing, J; Xie, C; Qu, J; Gao, Y; Lou, H (2007). "Study of bis(bibenzyls) in ... Bibenzyls (3,4'-dihydroxy-5,5'-dimethoxybibenzyl, 3,3'-dihydroxy-5-methoxybibenzyl (batatasin III)) can be found in the orchid ...
Cullmann F, Becker H (1999-04-01). "Prenylated Bibenzyls from the Liverwort Radula laxiramea". Zeitschrift für Naturforschung C ...
Prenylated bibenzyls can be isolated from M. epiphytum. Marsupidium epiphytum on Te Papa New Zealand's national museum website ... Toyota, Masao; Omatsu, Ikuko; Braggins, John; Asakawa, Yoshinori (2011). "Novel Prenyl Bibenzyls from the New Zealand Liverwort ...
... dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum". Phytochemistry. 44 (1): 157-165. doi:10.1016/s0031- ...
Phenanthrenes, dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum. Leong Y-W, KAng C-C, Harrison LJ and ...
Isonotholaenic acid, a dihydrostilbenoid, and other bibenzyls can be found in A. nivea. This compound shows an anti-chagasic ...
Toluene and bi-benzyls were produced as the product of the reaction. Morrison and his co-workers also reported dehalogenation ...
... bibenzyls MeSH D02.455.426.559.389.140.400 - 2-hydroxy-5-nitrobenzyl bromide MeSH D02.455.426.559.389.140.450 - lignans MeSH ... bibenzyls MeSH D02.455.426.559.389.150.700.100 - chlorotrianisene MeSH D02.455.426.559.389.150.700.125 - clomiphene MeSH ...
... bibenzyls, dibenzoxepins, mixture of phytol fatty esters, lutein, β-sitosterol, isoquercitin and astragalin.[citation needed] ...
... on www.uniprot.org Antifungal macrocyclic bis(bibenzyls) from the Chinese liverwort Ptagiochasm ...
... bibenzyls) from the Chinese liverwort Ptagiochasm intermedlum L. Chun-Feng Xie, Jian-Bo Qu, Xiu-Zhen Wu, Na Liu, Mei Ji and ...
... produces the antifungal bis[bibenzyls] dihydrostilbenoids plagiochin E, 13,13'-O-isoproylidenericcardin D ...
Stilbenoids belong to the phenylpropanoid pathway and include stilbenes, bibenzyls, and phenanthrenes derivatives. They are ...
Distribution of Cyclic and Acyclic Bis-bibenzyls in the Marchantiophyta (Liverworts), Ferns and Higher Plants and Their ... At present more than 70 of bis-bibenzyls have been found in liverworts. The structurally unique cyclic and acyclic bis- ... The Marchantiophyta (liverworts) are rich sources of cyclic and acyclic bis-bibenzyls which are very rare natural products in ... The present paper deals with the distribution of bis-bibenzyls in liverworts, fern and higher plants and their biological ...
Bibenzyls - Preferred Concept UI. M0002454. Scope note. Compounds that include 1,2-diphenylethane in their structure. ...
Kim, W., Lee, D., Hong, S. S., Na, Z., Shin, J. C., Roh, S. H., Wu, C. Z., Choi, O., Lee, K., Shen, Y. M., Paik, S. G., Lee, J. J. & Hong, Y. S., 2009 May 4, In: ChemBioChem. 10, 7, p. 1243-1251 9 p.. Research output: Contribution to journal › Article › peer-review ...
2. BIBENZYLS [ԴԻԲԵՆԶԻԼՆԵՐ] 52. BIOGRAPHY [ԿԵՆՍԱԳՐՈՒԹՅՈՒՆ] 3. BIBLE [ԱՍՏՎԱԾԱՇՈՒՆՉ] 53. BIOLOGICAL ASSAY [ԿԵՆՍԱԲԱՆԱԿԱՆ ՓՈՐՁ] ...
HIGHLIGHTS: HPLC-ESI-MS/MS method for the analysis of bibenzyls and bis (bibenzyls) in Dendrobium officinale. Easy-to-use ... A total of nine isolated bibenzyls and their glycosides, 22 bis (bibenzyls), and two phenylpropanol bibenzyl derivatives were ... Identification of bibenzyls and evaluation of imitative wild planting techniques in Dendrobium officinale by HPLC-ESI-MSn. ... In addition, the relative content of bibenzyls increased with the growth of the original plant. This study provided a ...
Hu JM, Chen JJ, Yu H, Zhao YX, Zhou JTwo novel bibenzyls from Dendrobium trigonopusJ Asian Nat Prod Res. .. (. 2008 Jul-Aug. ) ...
... bibenzyls, dibenzoxepins, mixture of phytol fatty esters, lutein, β-sitosterol, isoquercitrin and astragalin etc. The present ...
... were isolated from the roots of Stemona japonica together with two known bibenzyls, 3,5-dih.... Database: Alt HealthWatch ...
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Anti-metastatic Activities of Bibenzyls from Dendrobium pulchellum. *Anti-metastatic Activities of Bibenzyls from Dendrobium ... Studies on Antioxidant Activity of Bibenzyls and Phenolic Components from Dendrobium nobile ...
16 showed weak activity.CONCLUSION Most of the bibenzyls and phenolic components exhibited antioxidant activity in different ... was evaluated by DPPH free radical scavenging assay and oxygen radical absorbance capacity assay.RESULTS Three new bibenzyls ... OBJECTIVE To study the antioxidant activity of bibenzyls and phenolic components isolated from the 60% EtOH extract of ... OBJECTIVE To study the antioxidant activity of bibenzyls and phenolic components isolated from the 60% EtOH extract of ...
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1997. Phenanthrenes and bibenzyls from a Plagiochila species. Phytochemistry 46: 1069-1075. ...
... chlorinated bibenzyls, chlorinated phenols, and 9-chloro-retene. For 25 hydroxylated PCBs, a five parameter QSBR was developed ...
The cytotoxicity of the bis-bibenzyls was evaluated by the MTT (3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) ... along with the two known bis-bibenzyls: isomarchantin C and isoriccardin C. The structural determination of the new bis- ...
Bibenzyls Preferred Term Term UI T004730. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1968). ... Bibenzyls Preferred Concept UI. M0002454. Registry Number. 0. Scope Note. Compounds that include 1,2-diphenylethane in their ... Bibenzyls. Tree Number(s). D02.455.426.559.389.140.308. Unique ID. D001632. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Bibenzyls Preferred Term Term UI T004730. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1968). ... Bibenzyls Preferred Concept UI. M0002454. Registry Number. 0. Scope Note. Compounds that include 1,2-diphenylethane in their ... Bibenzyls. Tree Number(s). D02.455.426.559.389.140.308. Unique ID. D001632. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Bibenzyls Medicine & Life Sciences 80% * Rotenone Medicine & Life Sciences 55% * Oxidopamine Medicine & Life Sciences 18% ...
... mannuronic boolean inclined rap1gds1 rigid mce1a consistency microvenular lactobionic right thiophenolato bacteroid bibenzyls ...
Li Y, Zhang F, Wu ZH, Zeng KW, Zhang C, Jin HW, et al. Nitrogen-containing bibenzyls from Pleione bulbocodioides: Absolute ... Li et al.[50],[51] isolated five novel compounds, including four pyrrolidone-substituted bibenzyls and a prenylated flavone, ... Li B, Noriko M, Masea Y, Shuzo T. A polyphenol and two bibenzyls from Pleione bulbocodioides. Cheminform 1998;47:1637-40. ... Wang Y, Guan SH, Meng YH, Zhang YB, Cheng CR, Shi YY, et al. Phenanthrenes, 9,10-dihydrophenanthrenes, bibenzyls with their ...
Antimicrobial Chlorinated Bibenzyls from the Liverwort Riccardia marginata. Baek, Seung-Hwa, Phipps, Richard K, and Perry, ...
N0000166742 Bezafibrate N0000170491 BH3 Interacting Domain Death Agonist Protein N0000171609 Biafine N0000166399 Bibenzyls ...
1988) Distribution of cyclic bis(bibenzyls) in the South African liverwort Marchantia polymorpha ...
Angiogenesis Inhibitors , Pharmacology , Animals , Benzyl Compounds , Pharmacology , Bibenzyls , Pharmacology , Cell Count , ... In the present study, we investigated the inhibitory effects of six bibenzyls isolated from Dendrobium species on vascular ... All those bibenzyls inhibited VEGF-induced tube formation at 10 micromol x L(-1) except tristin, and of which moscatilin was ...
Phytochemistry: 4 bibenzyls isolated from D. pulchellum showed to facilitate anoikis (cell death resulting from failure to ...
Titus L, Hatch EE, Drake KM, Parker SE, Hyer M, Palmer JR, Strohsnitter WC, Adam E, Herbst AL, Huo D, Hoover RN, Troisi R. Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): A report from the US National Cancer Institute DES Third Generation Study. Reprod Toxicol. 2019 03; 84:32-38 ...
D12.644.50.200.75 Bibenzyls D2.455.426.559.389.150.700.75 Bile Pigments D4.345.783.249 Bilirubin D4.345.783.249.184 Biliverdine ...
... biaxiality biaxially Biaxin bib bibasic bibasilar bibbed bibber bibbers bibbery bibbing bibelot bibelots bibenzyl bibenzyls ...
Bibenzyls [D02.455.426.559.389.140.308] Bibenzyls * 2-Hydroxy-5-nitrobenzyl Bromide [D02.455.426.559.389.140.400] ...
Bibenzyls Bible Bibliography Bibliography as Topic Bibliography of Medicine Bibliography, Descriptive Bibliography, National ...

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