BH3 Interacting Domain Death Agonist Protein

Proto-Oncogene Proteins c-bcl-2

bcl-2-Associated X Protein

Apoptosis

Bufotalin

BH3 interacting-domain death agonist

Phorbol-12-myristate-13-acetate-induced protein 1

P53 upregulated modulator of apoptosis

Bcl-2

BID

Myristoylation

Lipid-anchored protein

List of MeSH codes (D12.644)

Photoactivated peptide

Bcl-2-associated X protein

C6orf222

Caspase 2

List of MeSH codes (D12.776.476)

Bcl-2-interacting killer

BCL2L11

Tyrosine-protein kinase BLK

Bcl-2-associated death promoter

Bcl-2 family

Programmed cell death

YWHAQ

Apoptosis

Apoptosis11

• Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. (nih.gov)
• GSH is released in cells undergoing apoptosis, and the present study indicates that the multidrug resistance-associated proteins (MRPs/ABCC) are responsible for this GSH release. (nih.gov)
• 5. Signal-Regulated Protein Kinases/Protein Kinase B-p53-BH3-Interacting Domain Death Agonist Pathway Regulates Gingipain-Induced Apoptosis in Osteoblasts. (nih.gov)
• 11. AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. (nih.gov)
• 16. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. (nih.gov)
• Although the administration of CoQ10 increased Bcl-2 anti-apoptotic protein, it did not show a potent synergistic effect along with HIIT to reduce obesity-related myocardial apoptosis. (ac.ir)
• Role of potato protein hydrolysate and exercise in preventing high-fat diet-induced hepatocyte apoptosis in senescence-accelerated mouse. (ac.ir)
• D'Arcy MS. Cell death: A review of the major forms of apoptosis, necrosis and autophagy. (ac.ir)
• Apoptosis in response to the ligand CD95L (also known as Fas ligand) is initiated by caspase-8, which is activated by dimerization and self-cleavage at death-inducing signaling complexes (DISCs). (ebi.ac.uk)
• We utilized a recombinant fluorescence resonance energy transfer (FRET) Bid probe to determine the kinetics of Bid cleavage and tBid translocation during death receptor-induced apoptosis in caspase 3-deficient MCF-7 cells. (rcsi.com)
• In contrast to death receptor-induced apoptosis, neurons showed a translocation of full-length Bid to the mitochondria. (rcsi.com)

Homology3

• 19. Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. (nih.gov)
• Bcl-2 homology domain (BH) 3-only proteins couple stress signals to evolutionarily conserved mitochondrial apoptotic pathways. (rcsi.com)
• The cDNA sequence for PEDF predicts a unique protein with strong homology to members of the serine protease inhibitor (serpin) superfamily. (nih.gov)

Cyclin-depend1

• Additionally, treatment with rhLIGHT increased the number, viability, and proliferation of cells by inducing the S/G2/M phase and upregulating the expression of various cyclin and cyclin dependent kinase (CDK) proteins. (bvsalud.org)

Apoptotic4

• This results in ubiquitin-mediated proteasomal degradation of mitofusin 2, leading to mitochondrial fragmentation and enhanced apoptotic cell death. (nih.gov)
• It is a pro-apoptotic protein that is activated by caspase cleavage. (nih.gov)
• Analysis of apoptotic signalling pathways reveals that TL-77 down-regulates expression of B-cell lymphoma 2 (Bcl-2) family proteins [Bid (BH3 interacting-domain death agonist), Bcl-xl (B-cell lymphoma-extra large) and Mcl-1 (induced myeloid leukaemia cell differentiation protein)] and stimulates caspase activation. (nottingham.ac.uk)
• The aim of this study was to determine the effect of high-intensity interval training (HIIT) and coenzyme Q10 (CoQ10) supplementation on myocardial apoptotic proteins in obese male rats. (ac.ir)

Binds2

• A member of the Bcl-2 protein family that reversibly binds MEMBRANES . (nih.gov)
• A stapled BID BH3 helix directly binds and activates BAX. (atlasgeneticsoncology.org)

Gene2

• No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. (cdc.gov)
• Association of BH3 interacting domain death agonist (BID) gene polymorphisms with proteinuria of immunoglobulin A nephropathy. (cdc.gov)

Recombinant2

• Description: Prolactin Receptor Rainbow Trout Extra Celleular Domain Recombinant ?produced in E.Coli is a non-glycosylated, Polypeptide chain containing 210 amino acids and having a molecular mass of 24034 Dalton. (ksiazkiwnauce.pl)
• Much of our progress in understanding PEDF relied on our development of overexpression systems that yielded recombinant proteins as functionally active neurotrophic factors identical to the native protein and ideal for biochemical, biophysical, and biological studies. (nih.gov)

Caspase10

• A C-terminal fragment of Bid protein that is produced by caspase cleavage. (nih.gov)
• Whereas TNFα preincubation leads to elevated levels of caspase-3 activity and cell death, pretreatment with IL-1β induces increased caspase-3 activity but keeps cells alive. (frontiersin.org)
• The treatment of hepatocytes with the BMDM supernatant, which contains both IL-1β and TNFα, sensitized to FasL-induced caspase-3 activation and cell death. (frontiersin.org)
• The B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), cytochrome c, BH3-interacting domain death agonist (Bid), caspase-8, and caspase-3 protein expressions were analyzed using western blotting. (ac.ir)
• HIIT program decreased Bax/Bcl-2 ratio (P = 0.012), Bid (P = 0.0001), cytochrome c (P = 0.003), caspase-8 (P = 0.006), and caspase-3 (P = 0.002) proteins and increased Bcl-2 (P = 0.001) proteins in heart muscle. (ac.ir)
• Previous work indicated that the degree of substrate cleavage by caspase-8 determines whether a cell dies or survives in response to a death stimulus. (ebi.ac.uk)
• To determine how a death ligand stimulus is effectively translated into caspase-8 activity, we assessed this activity over time in single cells with compartmentalized probes that are cleaved by caspase-8 and used multiscale modeling to simultaneously describe single-cell and population data with an ensemble of single-cell models. (ebi.ac.uk)
• We derived and experimentally validated a minimal model in which cleavage of caspase-8 in the enzymatic domain occurs in an interdimeric manner through interaction between DISCs, whereas prodomain cleavage sites are cleaved in an intradimeric manner within DISCs. (ebi.ac.uk)
• Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. (atlasgeneticsoncology.org)
• Caspase 8-mediated cleavage of the BH3-only protein Bid into a truncated protein (tBid) and subsequent translocation of tBid to mitochondria has been implicated in death receptor signaling. (rcsi.com)

Kinase1

• Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)

TBid1

• tBID is the active from of the protein and it redistributes from the CYTOSOL to MITOCHONDRIA to promote release of CYTOCHROME C . (nih.gov)

Mitochondrial1

• My major research interest at NIEHS is mitochondrial DNA (mt-DNA) replication and how the structure of replication proteins relates to mt-DNA stability and drug sensitivity. (nih.gov)

Plasma membrane2

• Focusing on retinoblastoma and cerebellar granule cells, we prospected for PEDF receptors and found evidence for 1) a saturable, specific, and high-affinity class of receptors on the surface of both cells, with characteristics of an 80-kDa plasma membrane protein, and 2) the amino-terminal region in PEDF that interacts with the receptor. (nih.gov)
• Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. (lookformedical.com)

Endoplasmic reticulum1

• The endoplasmic reticulum (ER) is a critical organelle for protein synthesis, folding and modification, and lipid synthesis and calcium storage. (molcells.org)

Receptor1

• Along these lines, our first priority is the identification of the PEDF receptor protein, and we are investigating cell-surface receptors in the normal and diseased retina. (nih.gov)

Antiapoptotic1

• 20. Structural insight into BH3 domain binding of vaccinia virus antiapoptotic F1L. (nih.gov)

Interaction1

• JNK phosphorylation of mitofusin 2 in response to cellular stress leads to recruitment of the ubiquitin ligase (E3) Huwe1/Mule/ARF-BP1/HectH9/E3Histone/Lasu1 to mitofusin 2, with the BH3 domain of Huwe1 implicated in this interaction. (nih.gov)

Synthesis2

• The UPR restores ER homeostasis by attenuating protein synthesis or by inducing the expression of various genes encoding molecular chaperones and protein processing enzymes that promote protein folding and post-translational modification. (molcells.org)
• RNA sequences that serve as templates for protein synthesis. (lookformedical.com)

Differentiation2

• My interests are in the area of protein structure as it relates to function, with a focus on the interactions of components involved in cell differentiation and survival. (nih.gov)
• My lab group has been studying pigment epithelium derived factor (PEDF), a protein that acts in neuronal differentiation and survival in cells derived from the retina and CNS. (nih.gov)

Inflammatory2

• These results give first insights into the complex interplay between macrophages and hepatocytes which may influence life/death decisions of hepatocytes during an inflammatory reaction of the liver in response to a bacterial infection. (frontiersin.org)
• Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training. (ac.ir)

Calcium1

• These motifs are found in many proteins that are regulated by calcium. (uams.edu)

Activation1

• The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. (atlasgeneticsoncology.org)

CYTOSOL1

• These transmembrane proteins are major transducers of the UPR in mammals and mediate multiple distinct signals from the ER to the cytosol. (molcells.org)

Cells1

• Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains. (lookformedical.com)

Cell death1

• Pathogenesis of most liver diseases is associated with sustained inflammation, causing enhanced cell death of hepatocytes and, finally, leading to chronic liver diseases ( Malhi and Gores, 2008 ). (frontiersin.org)

Stress1

• Protein quality control is monitored by a complex system that modulates ER function to resolve ER stress and dysfunction. (molcells.org)

Content1

• CoQ10 supplementation significantly increased Bcl-2 protein content (P = 0.001). (ac.ir)

Response1

• Dysregulation of ER functions leads to the accumulation of misfolded- or unfolded-protein in the ER lumen, and this triggers the unfolded protein response (UPR), which restores ER homeostasis. (molcells.org)