Dextromethorphan: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.Dextrorphan: Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN.Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.Levorphanol: A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.Cytochrome P-450 CYP2D6: A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.Oxidoreductases, O-Demethylating: Drug metabolizing enzymes which oxidize methyl ethers. Usually found in liver microsomes.Cold Temperature: An absence of warmth or heat or a temperature notably below an accustomed norm.Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.Codeine: An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.Whooping Cough: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.Gastric Dilatation: Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.Expectorants: Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.Morphinans: Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.Excitatory Amino Acid Antagonists: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.Common Cold: A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.Pseudobulbar Palsy: A syndrome characterized by DYSARTHRIA, dysphagia, dysphonia, impairment of voluntary movements of tongue and facial muscles, and emotional lability. This condition is caused by diseases that affect the motor fibers that travel from the cerebral cortex to the lower BRAIN STEM (i.e., corticobulbar tracts); including MULTIPLE SCLEROSIS; MOTOR NEURON DISEASE; and CEREBROVASCULAR DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p489)Receptors, sigma: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Memantine: AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.Dealkylation: The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Physician Self-Referral: Referral by physicians to testing or treatment facilities in which they have financial interest. The practice is regulated by the Ethics in Patient Referrals Act of 1989.Quackery: The fraudulent misrepresentation of the diagnosis and treatment of disease.Democracy: A system of government in which there is free and equal participation by the people in the political decision-making process.MoscowPharmacies: Facilities for the preparation and dispensing of drugs.Sneezing: The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.Hand Disinfection: The act of cleansing the hands with water or other liquid, with or without the inclusion of soap or other detergent, for the purpose of destroying infectious microorganisms.Soaps: Sodium or potassium salts of long chain fatty acids. These detergent substances are obtained by boiling natural oils or fats with caustic alkali. Sodium soaps are harder and are used as topical anti-infectives and vehicles in pills and liniments; potassium soaps are soft, used as vehicles for ointments and also as topical antimicrobials.Anti-Infective Agents, Local: Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.Disinfectants: Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)Ice Cream: A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.Ginger: Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically.Anacardium: A plant genus of the family ANACARDIACEAE. This is the source of the familiar cashew nuts, which are heat treated to remove the irritant toxin. Cashew nut shell liquid (frequently abbreviated as CNSL) is a major source of alkenyl phenolic compounds, especially ANACARDIC ACIDS, cardol, and cardanol.Coriandrum: A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.Pistacia: A plant genus in the ANACARDIACEAE family known for the Pistachio nuts and for gum Mastic.Nuts: Botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.Medicine, African Traditional: A system of traditional medicine which is based on the beliefs and practices of the African peoples. It includes treatment by medicinal plants and other materia medica as well as by the ministrations of diviners, medicine men, witch doctors, and sorcerers.Waste Water: Contaminated water generated as a waste product of human activity.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Respiratory Sounds: Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.Airway Resistance: Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.Dictionaries, Chemical

*Theraflu

... is a brand of over-the-counter cold and flu medicines from GSK Consumer Healthcare that contain different groupings of various cold and flu symptom medications. The original version of Theraflu contained acetaminophen (paracetamol) (1000 mg), chlorpheniramine maleate (4 mg), dextromethorphan hydrobromide (30 mg), and pseudoephedrine hydrochloride (60 mg). The Canadian and Swiss version is sold as NeoCitran. A British company, Reckitt Benckiser, markets a similar product as Lemsip (Lemsip is available in a variety of flavours and strengths containing up to 1,000 mg of paracetamol, and 12.2 mg phenylephrine hydrochloride). They also sell Theraflu Warming Relief in day and nighttime varieties, which contain alcohol and acetaminophen. Because pseudoephedrine is used in the production of methamphetamine, the original formula has been removed from production and a number of alternative formulations have been brought to market. In addition, the FDA has ...

*Levomethorphan

... (INN, BAN) is an opioid analgesic of the morphinan family that has never been marketed. It is the L-stereoisomer of racemethorphan (methorphan). The effects of the two isomers of the racemethorphan are quite different, with dextromethorphan (DXM) contrarily being an antitussive at low doses and a dissociative hallucinogen at much higher doses. It is about five times stronger than morphine. Levomethorphan is a prodrug to levorphanol, analogously to DXM acting as a prodrug to dextrorphan or codeine behaving as a prodrug to morphine. As such, levomethorphan has similar effects to levorphanol but is less potent as it must be demethylated to the active form by liver enzymes before being able to produce its effects. As a prodrug of levorphanol, levomethorphan functions as a potent agonist of all three of the opioid receptors, μ, κ (κ1 and κ3 but notably not κ2), and δ, as an NMDA receptor antagonist, and as a serotonin-norepinephrine reuptake inhibitor. Via activation of the KOR, ...

*Dextrallorphan

... (DXA) is an opioid derivative chemical of the morphinan class that is used in scientific research. It acts as a σ1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ2, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan is often used in research to block σ1 receptor sites so that σ2 receptor sites (which have not been cloned yet) can be studied. It was hypothesized that both of these sigma (σ) receptors were opioid receptors, due to their affinity for psychoactive drugs. However, it is now understood that they are non-opioid receptors that bind to certain psychoactive drugs, like dextrallorphan. One example of dextrallorphan being used to mask σ1 receptor sites was seen in a study on the localization of the σ2 receptor in detergent-resistant lipid ...

*Cough medicine

... s are medications used in those with coughing and related conditions. It is not known whether over-the-counter cough medications reduce coughing. While they are used by 10% of American children in any given week, they are not recommended in Canada and the United States in children 6 years or younger because of lack of evidence showing effect and concerns of harm. There are a number of different cough and cold medications, which may be used for various coughing symptoms. The commercially available products may include various combinations of any one or more of the following five types of substances: Expectorants are substances claimed to make coughing easier while enhancing the production of mucus and phlegm. Two examples are acetylcysteine and guaifenesin. Antitussives, or cough suppressants, are substances which suppress the coughing itself. Examples ...

*Quinidine

... is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart. It is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as a prolonged QT interval. Quinidine is used as a class I antiarrhythmic agent, that is, to prevent ventricular arrhythmias. It is also used to maintain sinus rhythm after cardioversion of atrial fibrillation and to treat short QT syndrome. A combination of dextromethorphan and quinidine has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis. This drug is marketed as Nuedexta in the United States. Intravenous quinidine is also indicated for treatment of Plasmodium falciparum malaria. However, quinidine is not considered the first-line therapy for P. falciparum. The recommended treatments for P. falciparum malaria, according to the Toronto Notes 2008, ...

*Serotonin syndrome

... (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs. The degree of symptoms can range from mild to severe. Symptoms include high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea. Body temperature can increase to greater than 41.1 °C (106.0 °F). Complications may include seizures and extensive muscle breakdown. Serotonin syndrome is typically caused by the use of two or more serotonergic medications or drugs. This may include selective serotonin reuptake inhibitor (SSRI), serotonin norepinephrine reuptake inhibitor (SNRI), monoamine oxidase inhibitor (MAOI), tricyclic antidepressants (TCAs), amphetamines, pethidine (meperidine), tramadol, dextromethorphan, buspirone, L-tryptophan, 5-HTP, St. John's wort, triptans, ecstasy (MDMA), metoclopramide, ondansetron, or cocaine. It occurs in about 15% of SSRI overdoses. It is a predictable consequence of excess serotonin on the central ...

*Levomethorphan

... (INN, BAN) is an opioid analgesic of the morphinan family that has never been marketed. It is the L-stereoisomer of racemethorphan (methorphan). The effects of the two isomers of the racemethorphan are quite different, with dextromethorphan (DXM) contrarily being an antitussive at low doses and a dissociative hallucinogen at much higher doses. It is about five times stronger than morphine. Levomethorphan is a prodrug to levorphanol, analogously to DXM acting as a prodrug to dextrorphan or codeine behaving as a prodrug to morphine. As such, levomethorphan has similar effects to levorphanol but is less potent as it must be demethylated to the active form by liver enzymes before being able to produce its effects. As a prodrug of levorphanol, levomethorphan functions as a potent agonist of all three of the opioid receptors, μ, κ (κ1 and κ3 but notably not κ2), and δ, as an NMDA receptor antagonist, and as a serotonin-norepinephrine reuptake inhibitor. Via activation of the KOR, ...

*Dextrallorphan

... (DXA) is an opioid derivative chemical of the morphinan class that is used in scientific research. It acts as a σ1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ2, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan is often used in research to block σ1 receptor sites so that σ2 receptor sites (which have not been cloned yet) can be studied. It was hypothesized that both of these sigma (σ) receptors were opioid receptors, due to their affinity for psychoactive drugs. However, it is now understood that they are non-opioid receptors that bind to certain psychoactive drugs, like dextrallorphan. One example of dextrallorphan being used to mask σ1 receptor sites was seen in a study on the localization of the σ2 receptor in detergent-resistant lipid ...

*Habit cough

A habit cough (also known inappropriately as psychogenic cough, tic cough, and somatic cough disorder) is a cough that may develop in children or adolescents after a cold or other airway irritant.[1] Similar symptoms have been less frequently reported in adults but may not be the same disorder as is seen in children or adolescents. First described in 1966 in a small series treated by "the art of suggestion,"[2] further publications identified patients with the same symptoms treated effectively with suggestion therapy.[3][4][5][6][7] The average age has been reported as 10 years at clinics in Iowa, Minnesota, and London England.[7] Eighty-five percent of 120 children diagnosed with habit cough over 20 years in Iowa were between ages 8 and 14 with a range from 5 to 18.[5] Based on experience in Iowa and London, major referral centers for children may be expected to encounter at least 7-9 per ...

*Cough medicine

... s are medications used in those with coughing and related conditions. It is not known whether over-the-counter cough medications reduce coughing. While they are used by 10% of American children in any given week, they are not recommended in Canada and the United States in children 6 years or younger because of lack of evidence showing effect and concerns of harm. There are a number of different cough and cold medications, which may be used for various coughing symptoms. The commercially available products may include various combinations of any one or more of the following five types of substances: Expectorants are substances claimed to make coughing easier while enhancing the production of mucus and phlegm. Two examples are acetylcysteine and guaifenesin. Antitussives, or cough suppressants, are substances which suppress the coughing itself. Examples ...

*Acute bronchitis

... , also known as a chest cold, is short-term inflammation of the bronchi (large and medium-sized airways) of the lungs. The most common symptom is a cough. Other symptoms include coughing up mucus, wheezing, shortness of breath, fever, and chest discomfort. The infection may last from a few to ten days. The cough may persist for several weeks afterward with the total duration of symptoms usually around three weeks. Some have symptoms for up to six weeks. In more than 90% of cases the cause is a viral infection. These viruses may be spread through the air when people cough or by direct contact. Risk factors include exposure to tobacco smoke, dust, and other air pollution. A small number of cases are due to high levels of air pollution or bacteria such as Mycoplasma pneumoniae or Bordetella pertussis. Diagnosis is typically based on a person's signs and symptom. The color of the sputum does not indicate if the infection is ...

*NorthShore University HealthSystem

... (NorthShore) is an integrated healthcare delivery system serving patients throughout the Chicago metropolitan area. NorthShore encompasses four Hospitals-Evanston, Glenbrook, Highland Park and Skokie-as well as NorthShore Medical Group with more than 70 offices and more than 800 primary and specialty care physicians, the Research Institute and Foundation. In total, the health system employs more than 8,000 people. NorthShore has a teaching affiliation with the University of Chicago Pritzker School of Medicine. NorthShore was founded as Evanston Hospital in 1891. The original six-bed hospital had 12 physicians and served 38 patients in its first year. In the early 1900s Evanston Hospital expanded to 250 beds and became a teaching hospital. Louis W. Sauer developed a vaccine for Whooping Cough at Evanston Hospital in the 1920s. The hospital affiliated with Northwestern University and the Feinberg School of Medicine in the 1930s. Evanston Hospital expanded to 475 ...

*Mucoprotective

... agents are pharmaceutical or herbal medicines that protect mucous membrane tissues. They include such things as demulcents. Bone, Kerry (2007). The Ultimate Herbal Compendium. Phyotherapy Press. ISBN 978-0-646-47602-5. [page needed] Rouhi, Hamid, and Forouzan Ganji. "Effect of Althaea officinalis on cough associated with ACE inhibitors." Pakistan Journal of Nutrition 6.3 (2007): 256-258. Boyd, Eldon M. (1952). "Cough medication and antihistaminic drugs". Can Med Assoc J. 67 (4): 289-92. PMC 1822606 . PMID 13009543. Sakamoto, C (2004). "The role of mucoprotective drugs in gastric ulcer treatment: with specific reference to their effects on gastritis mucosa". Nippon rinsho. Japanese journal of clinical medicine. 62 (3): 566-70. PMID 15038105. DRUG PROFILE OF NOVAL ANTIULCER AND MUCOPROTECTIVE ...
TY - JOUR. T1 - High affinity [3H]dextrorphan binding in rat brain is localized to a noncompetitive antagonist site of the activated N-methyl-D-aspartate receptor-cation channel. AU - Franklin, P. H.. AU - Murray, T. F.. PY - 1992/2/21. Y1 - 1992/2/21. N2 - [3H]Dextrorphan recognition sites were characterized in rat brain membranes. The pharmacological profile and regional distribution of [3H]dextrorphan binding sites appear to distinguish these sites from those labeled either by [3H]dextromethorphan or by putative σ receptor radioligands. Data from thoroughly washed forebrain membranes suggest that [3H]dextrorphan predominantly labels a high affinity site defined by the activated state of the N-methyl-D-aspartate (NMDA) receptor-channel complex. Regulation of [3H]dextrorphan binding by specific modulators of NMDA receptor function suggests that [3H]dextrorphan binding is predominantly localized to a domain of the receptor-channel complex also recognized by the prototypical noncompetitive ...
The results of the present study show that both dextromethorphan and dextrorphan stimulate the HPA axis in the rat; however, the time course of the responses produced by the two drugs was not identical. Significant increases in plasma ACTH levels were observed 30 min after the administration of either dextromethorphan or dextrorphan, whereas only dextromethorphan produced a significant increase in plasma corticosterone at this time point. Moreover, the dextromethorphan-induced increase in plasma ACTH was maximal 30 min after drug administration. In contrast, the dextrorphan-induced increases in both ACTH and corticosterone peaked at the 60-min time point. Thus, the dextromethorphan-induced stimulation of the HPA axis occurred more rapidly and reached a maximum at an earlier time point than the dextrorphan-induced responses. In an earlier study Eisenberg and Sparber (1979) did not find that dextrorphan increased plasma levels ...
This sheet talks about exposure to dextromethorphan in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider.. What is dextromethorphan?. Dextromethorphan is an over-the-counter cold medication that is used to treat cough. Dextromethorphan is available in pill, liquid and cough drop forms. It can be purchased on its own and is also found as an ingredient in multi-symptom cold, cough, and flu medications.. During pregnancy and while breastfeeding, its best to avoid combination medications that contain multiple ingredients to tackle many symptoms. Instead, choose single medications that treat only the symptoms you currently have. Some cold and cough medications contain alcohol. If you need to take ...
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The disposition of dextrorphan after single ascending iv doses and multiple iv dosing regimens was studied in Marshall beagle dogs. A dose-dependent decrease in plasma clearance was observed after the administration of single iv doses of 0.88 mg/kg, 2.64 mg/kg, and 8.8 mg/kg of dextrorphan (i.e. mean plasma clearance values +/- SD were 100 +/- 25 vs. 68 +/- 28 vs. 48 +/- 20 ml/min.kg, respectively; p less than 0.001). Upon multiple dosing, the plasma clearance of dextrorphan increased in a time-dependent fashion for the two highest doses, approaching values observed for the 0.88 mg/kg/day iv dosing regimen. Female dogs exhibited a greater increase in plasma clearance with time. For all dogs, however, dextrorphan plasma clearance approached or exceeded hepatic plasma flow rate, suggesting the possibility of extrahepatic metabolism or elimination. Modest dose- and time-dependent changes in the steady-state volume of distribution of dextrorphan also were observed. The AUC of the conjugated ...
Text of S. 2274 (110th): Dextromethorphan Abuse Reduction Act of ... as of Oct 31, 2007 (Introduced version). S. 2274 (110th): Dextromethorphan Abuse Reduction Act of 2007
The N-methyl-D-aspartate (NMDA) antagonist dextromethorphan (DXM) is an antitussive cough suppressant chemically related to codeine. Originally categorized as a synthetic opioid, DXM appears to function through both NMDA receptor and sigma-1 receptor activity. Available since the 1950s, dextromethorphan can be found in more than 140 different cough-and-cold remedies - both prescription and over the counter. When given for a cough at recommended low doses, usually it is free of serious side effects. But when the drug is taken in higher amounts, bizarre behavior, including hallucinations, is common. DXM can cause tiredness, dizziness, skin rashes and sedation, as well as stupor, restlessness, coma, high blood pressure, respiratory depression, rapid heart rate (tachycardia), toxic psychosis (delusions, disorganized speech with lost contact to reality), nausea and vomiting. It also lowers the seizure threshhold, ...
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One hundred patients were randomized to two groups. Group DEX was given 30 mg tablets of oral dextromethorphan with their pre-medication and three more times in the first 24 hours after surgery. Group P received the placebo following the same schedule. Post-operative analgesic requirements were assessed using a patient-controlled analgesia system.. Pain was assessed at rest using a visual analog scale in the post anesthetic care unit(PACU), 6 and 24 hours after surgery. ...
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Chlorpheniramine + bromhexine + dextromethorphan + pseudoephedrine + guaifenesin is used in the treatment of cough.get complete information about chlorpheniramine + bromhexine + dextromethorphan + pseudoephedrine + guaifenesin including usage, side effects, drug interaction, expert advice along with medicines associated with chlorpheniramine + bromhexine + dextromethorphan + pseudoephedrine + guaifenesin at 1mg.com
The present study has shown that cimetidine is a weak, reversible inhibitor of CYP2D6 in vitro, a finding consistent with reports from other laboratories (Martinez et al., 1999; Furuta et al., 2001). Additionally, evidence presented here suggests that cimetidine acts as a mechanism-based inactivator of CYP2D6. A 31% decrease in recombinant CYP2D6 activity was observed following preincubation with cimetidine, NADPH, and antioxidants. This loss in activity was time-dependent and was consistent with the catalysis-dependent formation of a reactive metabolite or metabolite-intermediate species, as previously demonstrated in animal studies with CYP2C11 and CYP2C6 (Chang et al., 1992b; Levine and Bellward, 1995; Levine et al., 1998). Furthermore, inactivation of recombinant CYP2D6 was attenuated by quinidine. As a competitive inhibitor of CYP2D6, quinidine would be able to reduce the formation of the putative inactivating species in a concentration-dependent manner if CYP2D6-mediated metabolism is ...
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The bill enjoyed the support of industry leaders, including the Consumer Healthcare Products Association. "We take very seriously our obligation to educate and raise awareness about cough medicine abuse among teens," CHPApresident and CEO Scott Melville said. "This unprecedented action by California lawmakers will help address medicine abuse and sets a high standard that we would ultimately like to see enacted nationwide.". Dextromethorphan is a safe and effective ingredient found in more than 100 over-the-counter cough-cold products; however, some teens abuse large amounts of cough medicine containing dextromethorphan - sometimes as much as 25 to 50 times the recommended dose - to get high.. Aside from calling for a national age restriction on DXM-containing medicines, CHPA has been engaged in educational efforts to curb teen cough medicine abuse for a number of years, and ...
DESCRIPTION Each 5 mL (one teaspoonful) contains: Brompheniramine Maleate 2.0 mg Dextromethorphan Hydrobromide 10 mg Phenylpropanolamine Hydrochloride 12.5 mg Brompheniramine Maleate, Dextromethorphan HBr and Phenylpropanolamine ...
Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Dextromethorphan and guaifenesin is a combination medicine used to treat cough and...
Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity ...
Get an overview of DAYCLEAR COUGH COLD AND FLU (choline salicylate, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride liquid), including warnings and precautions, directions, and the names of other drugs and products that include the same medication.
Get an overview of TRIAMINIC COUGH AND CONGESTION (dextromethorphan hydrobromide, guaifenesin liquid), including warnings and precautions, directions, and the names of other drugs and products that include the same medication.
Physician reviewed acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine patient information - includes acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine description, dosage and directions.
Welcome to the Acetaminophen + Dextromethorphan + Pseudoephedrine information hub. Featuring active ingredients, dosages, related medications, and Acetaminophen + Dextromethorphan + Pseudoephedrine forums.
More information is available on dextromethorphan + doxylamine + paracetamol + pseudoephedrine including side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information.
A radioactive analogue of levorphanol, [3H]N-β-(p-azidophenyl)ethylnorlevorphanol (compound 6), has been synthesized as a photochemical affinity label for the opiate receptor site(s). It has potent opiate-like pharmacological activity in whole mice and isolated intact guinea pig ileum Upon photolysis of the analogue in the presence of bovine serum albumin as a test protein, radioactivity is incorporated into the protein. Photolysis of the analogue in the presence of total particulate matter from whole mouse brain results in incorporation of radioactivity into a pellet insoluble in water and organic solvent. This incorporation is significantly but incompletely blocked by both levorphanol and dextrorphan. Incorporation into guinea pig ileum longitudinal muscle strips is also observed but is not significantly blocked by levorphanol or dextrorphan. The implications of the results are discussed.. ...
Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages...
Learn about the potential side effects of brompheniramine/dextromethorphan/guaifenesin/phenylephrine. Includes common and rare side effects information for consumers and healthcare professionals.
Levomethorphan (INN, BAN) is an opioid analgesic of the morphinan family that has never been marketed. It is the L-stereoisomer of racemethorphan (methorphan). The effects of the two isomers of the racemethorphan are quite different, with dextromethorphan (DXM) contrarily being an antitussive at low doses and a dissociative hallucinogen at much higher doses. It is about five times stronger than morphine. Levomethorphan is a prodrug to levorphanol, analogously to DXM acting as a prodrug to dextrorphan or codeine behaving as a prodrug to morphine. As such, levomethorphan has similar effects to levorphanol but is less potent as it must be demethylated to the active form by liver enzymes before being able to produce its effects. As a prodrug of levorphanol, levomethorphan functions as a potent agonist of all three of the opioid receptors, μ, κ (κ1 and κ3 but notably not κ2), and δ, as an NMDA receptor antagonist, and as a serotonin-norepinephrine reuptake inhibitor. Via activation of the KOR, ...
NYQUIL-D (Acetaminophen,Dextromethorphan,Pseudoephedrine,Doxylamine succinate) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
BROMFED-DM (Dextromethorphan,Pseudoephedrine,Brompheniramine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Murine neuronal and glial cell cultures exposed briefly to glutamate accumulated large amounts of 45Ca2+ from the extracellular medium during the exposure. Most of the accumulation likely reflected influx into neurons, as little accumulation was observed in similarly treated glial cultures. When the concentration of glutamate was varied between 10 and 1000 microM, or exposure duration was varied between 0 and 10 min, the amount of 45Ca2+ accumulation correlated closely with the amount of neuronal death 24 hr later. Both 45Ca2+ accumulation and cell death could be attenuated in a dose-dependent manner by the competitive NMDA antagonist D-aminophosphonovalerate or the noncompetitive antagonist dextrorphan, with IC50 values of approximately 100 microM and 15 microM, respectively. In contrast, neither 45Ca2+ accumulation nor cell death was blocked by the alpha-amino-3-hydroxy-5-methyl-4- isoxazole propionic acid (AMPA)/kainate antagonist 6-cyano-7- nitroquinoxaline-2,3-dione (CNQX) in the presence ...
TY - JOUR. T1 - Intracellular free calcium increases in cultured cortical neurons deprived of oxygen and glucose.. AU - Goldberg, M. P.. AU - Choi, D. W.. PY - 1990/11/1. Y1 - 1990/11/1. N2 - Dissociated neocortical cultures from fetal mice exposed transiently to a medium lacking both glucose and oxygen developed neuronal degeneration without glial degeneration. We have found that this injury depends on extracellular calcium and is associated with uptake of calcium from the culture medium. We measured free cytoplasmic calcium in individual neurons using the fluorescent calcium indicator fluo-3 and provide evidence that oxygen and glucose deprivation injury increases the intracellular calcium signal. Both intracellular calcium elevation and subsequent neuronal loss could be blocked by the N-methyl-D-aspartate receptor antagonist dextrorphan.. AB - Dissociated neocortical cultures from fetal mice exposed transiently to a medium lacking both glucose and oxygen developed neuronal degeneration ...
BACKGROUND: Endoxifen serum concentrations seem to correlate with outcome in breast cancer (BC) patients. Concurrently, cytochrome P450 2D6 (CYP2D6) enzyme activity and dextromethorphan (DM) metabolism are deemed a surrogate marker for the formation of endoxifen. Here, we conducted a matched cohort study to determine the impact of an extensive CYP2D6 phenotype on relapse in patients with early-stage estrogen receptor (ER)-positive BC and adjuvant tamoxifen intake. METHODS: CYP2D6 extensive metabolism was determined upon appropriate dextromethorphan/dextrorphan (DM/DX) urinary excretion ratios (≤0.30). Fifty-nine BC patients were identified as extensive phenotype metabolizers, while for 148 matched controls, CYP2D6 was not determined. Patients and controls did not differ with respect to age, stage, hormone receptor status, HER2, grade, menopausal status, chemotherapy and antihormonal therapy. Survival analysis was performed according to clinical follow-up. RESULTS: ...
(S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride [(-)-OSU6162] is a weak dopamine D2 receptor modulator that possesses potential for the treatment of levodopa (L-DOPA)-induced dyskinesias in patients with Parkinsons disease. In this report, incubations with human liver microsomes revealed that (-)-OSU6162 is selectively metabolized via N-dealkylation to yield N-depropyl (-)-OSU6162. Kinetics evidence is presented that the N-depropylation of (-)-OSU6162 in human hepatic microsomes is mediated by multiple cytochrome p450 (p450) enzymes, in particular CYP2D6. This hypothesis is borne out by several lines of in vitro evidence; 1). incubations of (-)-OSU6162 (5 micro M) with hepatic microsomes from a panel of human donors showed that (-)-OSU6162 N-depropylase activity correlated well with CYP2D6-catalyzed dextromethorphan O-demethylase activity but not with other p450 enzyme-specific activities; 2). quinidine, a CYP2D6-specific inhibitor, inhibited (-)-OSU6162 N-depropylation, ...
BACKGROUND Tamoxifen is frequently used for the treatment of hormone receptor positive breast cancer (BC). Mainly CYP2D6 is responsible for the transformation to therapeutically active metabolites, but CYP2C19, CYP2C9 and CYP2B6 also are involved. We investigated the impact of polymorphisms within the genes encoding these CYP enzymes on the relapse-free time (RFT) in patients with BC. METHODS Ninety-nine patients with hormone receptor positive BC, who had undergone adjuvant tamoxifen therapy, were genotyped for seventeen common variants within the genes encoding CYP2D6, CYP2C9, CYP2C19 and CYP2B6 using TaqMan and PCR-RFLP technology. Kaplan-Meier and Cox regression analyses were performed to elucidate the impact of genetic variants on RFT. Furthermore, CYP2D6 metabolic activity was determined in a subset of 50 patients by assessing dextromethorphan/dextrorphan urinary excretion ratios. CYP2D6 activity was compared to the CYP2D6 allelic combinations to evaluate the predictive value of the ...
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Question - What can cause sore throat, runny nose and clay colored stool while on Dextromethorphan for cough?. Ask a Doctor about uses, dosages and side-effects of Tylenol, Ask a Gastroenterologist
In this study, N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced the head-twitch response induced by 5-hydroxytryptamine (5-HT) in reserpine-treated mice. To minimize the risk of any indirect involvement of NMDA-receptor antagonists (D(-)-2-amino-5-phosphonopentanoic acid (AP-5), D(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP), (+)-5-methyl-10,11-dihydroxy-5H-dibenzo-[a,d]-cyclohepten-5,10-imi ne (MK-801), ketamine, dextrorphan and dextromethorphan) with 5-HT neurones, vesicle stores of monoamines, especially 5-HT, were depleted with reserpine. In addition, the enhancement of 5-HT-induced head-twitch response was inhibited by apomorphine and NMDA as well as ritanserin in reserpine-treated mice. These results support our previous conclusion that NMDA receptors play important roles in the glutamatergic modulation of 5-HTergic function at the postsynaptic 5-HT2 receptors in mice ...
Dextrallorphan (DXA) is an opioid derivative chemical of the morphinan class that is used in scientific research. It acts as a σ1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ2, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan is often used in research to block σ1 receptor sites so that σ2 receptor sites (which have not been cloned yet) can be studied. It was hypothesized that both of these sigma (σ) receptors were opioid receptors, due to their affinity for psychoactive drugs. However, it is now understood that they are non-opioid receptors that bind to certain psychoactive drugs, like dextrallorphan. One example of dextrallorphan being used to mask σ1 receptor sites was seen in a study on the localization of the σ2 receptor in detergent-resistant lipid ...
Racemorphan, or morphanol, is the racemic mixture of the two stereoisomers of 17-methylmorphinan-3-ol, each with differing pharmacology and effects: Dextrorphan - an antitussive and dissociative hallucinogen (NMDA receptor antagonist) Levorphanol - an opioid analgesic Racemorphan itself is under international control per the Single Convention on Narcotic Drugs 1961 and is therefore listed as a Schedule II Narcotic controlled substance in the US Controlled Substances Act 1970; it has an ACSCN of 9733 and in 2014 it had an aggregate annual manufacturing quota of zero. The salts in use are hydrobromide (free base conversion ratio 0.741), hydrochloride (0.876), and tartrate (0.632 ...
a) Schedule II shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the Controlled Substances Code Number set forth opposite it.. (b) Substances, vegetable origin or chemical synthesis. Unless specifically excepted or unless listed in another schedule, any of the following substances whether produced directly or indirectly by extraction from substances of vegetable origin, or independently by means of chemical synthesis, or by a combination of extraction and chemical synthesis:. (1) Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding apomorphine, thebaine-derived butorphanol, dextrorphan, nalbuphine, nalmefene, naloxone, and naltrexone, and their respective salts, but including the following:. (i) Codeine 9050. (ii) Dihydroetorphine 9334. (iii) Ethylmorphine 9190. (iv) Etorphine hydrochloride ...
65-4107. Substances included in schedule II. (a) The controlled substances listed in this section are included in schedule II and the number set forth opposite each drug or substance is the DEA controlled substances code which has been assigned to it.. (b) Any of the following substances, except those narcotic drugs listed in other schedules, whether produced directly or indirectly by extraction from substances of vegetable origin or independently by means of chemical synthesis or by combination of extraction and chemical synthesis:. (1) Opium and opiate and any salt, compound, derivative or preparation of opium or opiate, excluding apomorphine, dextrorphan, nalbuphine, nalmefene, naloxone and naltrexone and their respective salts, but including the following:. (A) Raw opium 9600. (B) Opium extracts 9610. (C) Opium fluid 9620. (D) Powdered opium 9639. (E) Granulated opium 9640. (F) Tincture of opium 9630. (G) Codeine 9050. (H) Ethylmorphine 9190. (I) Etorphine hydrochloride 9059. (J) Hydrocodone ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...
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Insomnia is a common complaint or disorder throughout the world. About one third of the population in the industrial countries reports difficulty initiating or maintaining sleep, resulting in a non-refreshing or non-restorative sleep. The majority of the insomniacs suffer chronically from their complaints.. The maleic acid salt of Org 4420, code name Org 50081 (esmirtazapine), was selected for development in the treatment of insomnia. The first clinical trial with esmirtazapine was a proof-of-concept trial with a four-way cross-over design. All 3 esmirtazapine dose groups showed a statistically significant positive effect on Total Sleep Time (TST) (objective and subjective) and Wake Time After Sleep Onset (WASO), as compared to placebo.. The current study is a 52-week safety study in elderly outpatients with chronic primary insomnia randomized to treatment with 1.5 mg or 3.0 mg of esmirtazapine to investigate the safety and tolerability of long-term treatment with esmirtazapine in elderly ...
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This medication is a cough suppressant and expectorant combination. The Dextromethorphan (DM for short) is the cough suppressant part of this medication. It acts by blocking the cough reflex center in the brain. It will offer temporary relief (a few hours) to that nagging cough caused by a "tickle" in the throat. The Guaifenesin is the expectorant; it will help thin out the mucous in the sinuses and throat. There is a common misconception that this combination is not a good idea, i.e. with the cough suppressed, the thinned mucous will just run down into the lungs and cause pneumonia. What really happens is that the thinned mucous is more easily cleared out of the sinuses and airways by the microscopic hairs (called cilia) that line the passages. Of course, "hosing the nose" with saline spray and "steaming" the sinuses are also effective at keeping mucous thin. ...
Although dextromethorphan has withdrawn a pediatric indication in some countries, this does not extend subsidies to the use of Mucinex multi - action wet & dry paroxysmal cough liquid. Simultaneous treatment of cells with leucocyte interferon and Cough childrens mucus relief, tween 80 or dextromethorphan also materially reduced the action of the interfe
Senate Bill 514 would prohibit the sale of non-prescription drugs containing dextromethorphan (DXM) to a person under the age of 18. Dextromethorphan is a cough suppressant commonly found in over-the-counter cold medications. Minors purchase and consume large quantities of products that contain DXM in order to get high. Ingesting too much cold medicine can be just as hazardous as drinking too much alcohol. And it is cheap, easy and legal for young people to obtain.. After this bill passed the Legislature Senator Simitian sent a letter to the Governor urging his signature. For more information, you can read the SB 514 "Fact Sheet" prepared by a member of Senator Simitians staff.. ...
Cough medicines are medications used in those with coughing and related conditions. It is not known whether over-the-counter cough medications reduce coughing. While they are used by 10% of American children in any given week, they are not recommended in Canada and the United States in children 6 years or younger because of lack of evidence showing effect and concerns of harm. There are a number of different cough and cold medications, which may be used for various coughing symptoms. The commercially available products may include various combinations of any one or more of the following five types of substances: Expectorants are substances claimed to make coughing easier while enhancing the production of mucus and phlegm. Two examples are acetylcysteine and guaifenesin. Antitussives, or cough suppressants, are substances which suppress the ...
Chlorpheniramine, dextromethorphan, and phenylephrine requires locating a prescription and sink as of 2010 is yet sold under the brand whose name Nasohist - dm by bioniche pharma, llc. Sildec - pe dm may be used in combination therapies with other antiepileptic drugs without expressing concern for alteration of the blood concentrations of good product, however best if advised me by a doctor or of other antiepileptic drugs.. Read More. ...
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Guaifenesin. Guaifenesin protocol is an unapproved treatment for fibromyalgia suggested in the 1990s by R. Paul St. Amand. The protocol involves three parts: titrating the guaifenesin dosage, avoiding salicylates, and following a low-carbohydrate diet if the patient is hypoglycemic. Guaifenesin has not been approved by the FDA for the treatment of fibromyalgia, and the protocol has not been shown to be effective in clinical trials. Despite the demonstrated lack of clinical efficacy, the protocol has been adopted by many due to anecdotal evidence of success.. Contents 1 Treatment details 1.1 Guaifenesin dosage 1.2 Avoiding salicylates 2 Hypothesis 3 Lack of Efficacy 4 History 5 References. Treatment details Guaifenesin dosage. The dosage is individually determined by slowly titrating the dosage up until a worsening of symptoms is noticed and there is a decrease of the lesions that can be palpated in the muscles. Patients begin with 300 mg twice a day and increase from there. The guaifenesin ...
Just because a drug or medicine is sold at your local pharmacy or supermarket, that doesnt mean that it is safe for you to use while you are being treated for cancer. Many over-the-counter medicines can interact with cancer-fighting medications. You should always talk to your doctor or nurse before taking any sort of medication.. There is a big misunderstanding among teenagers and adults that it is safer to "abuse" medicines sold at stores than those that are illegal. Although these medicines are safer in that they are made in a controlled, safe environment, not following their dosing instructions or abusing them can have similar outcomes to those of illegal drugs and alcohol.. Cough medicine is a common household medication that is abused by teenagers. The common ingredient in many cough and cold remedies, Dextromethorphan (DXM), (a cough suppressant) is found in at least 70 over-the-counter products, ...
This blended cough syrup is used to address manifestations created by the basic cough, influenza, anaphylaxes, roughage fever, cold, or other respiration sicknesses, for example, bronchitis, sinusitis). The cough suppressant in Bromfed DM is Dextromethorphan, which manipulates the brain to reduce the desire to cough. Decongestants help ease stuffy nose side effects such as runny nose. Antihistamines diminish eye problems such as wet, itchy, red eye.. For Kids: Bromfed DM cough syrup in not designed for kids, even other cough syrups are not recommended for kids under 6. So contact a doctor for children coughing instead of taking the advantage of this syrup. It can lead to severe conditions in kids such as lung failure, mood changes, low bone density. Approach to your specialist or drug specialist for more insights about utilizing your item securely. These ...
Abundant evidence suggests that NMDA receptors are involved in the nociceptive responses to formalin. Pretreatment with a competitive NMDA receptor antagonist [e.g., APV[3-amino-5-phosphonovaleric acid] or a noncompetitive NMDA receptor antagonist {e.g.,MK-801, [(+)-5 methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine hydrogen maleate], dextromethorphan or ketamine} reduces nociceptive behavioral and/or electrophysiological responses induced by formalin (Coderre and Melzack, 1992; Haley et al., 1990;Yamamoto and Yaksh, 1992; Vaccarino et al., 1993; Hunter and Singh, 1994; Elliott et al., 1995; Shimoyama et al., 1996). The effects of NMDA receptor antagonists are primarily on phase 2 behaviors of the formalin response (Coderre and Melzack, 1992). Phase 2 of the formalin test appears to reflect central sensitization. The barrage of C-fiber inputs produced by formalin most likely activates spinal cord NMDA receptors, which results in the sensitization of dorsal horn neurons. This ...
These caps are a choking hazard, kamagra oral jelly suppliers india so be sure to remove them before putting the syringe in your childs mouth. Nortriptyline is a tricyclic compound, buy kamagra oral jelly canada specifically a dibenzocycloheptadiene, and possesses three rings fused together with a side chain attached in its chemical structure. This combination may lead to the development of a hyperserotonergic syndrome consisting of excitement, diaphoresis, rigidity, hyperthermia, tachycardia, hypertension, and possibly death! Brompheniramine; Dextromethorphan; Guaifenesin: (Moderate) Coadministration of gabapentin with anxiolytics, buy kamagra oral jelly canada sedatives, and hypnotics may increase CNS depressive effects such as drowsiness and dizziness? This spokewise buy detrol could be a issue with my internet browser because Ive had this happen before. Morì più index genere a benedizione villana politica pomodori donna adolescenti tempo capitelli strada to a radici umoristici defunti ...
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2) Cough Remedy: Swallowing buckwheat honey (warning, only for individuals over a year of age, due to botulism risk) Why it works: A 2007 study showed that children who received a small dose of buckwheat honey before bedtime slept better and coughed less than those who received either a common over-the-counter cough suppressant (dextromethorphan) or nothing at all. Darker honeys (like buckwheat) have more antioxidents, and cost less than OTC meds, which have other side effects. Usefulness can perhaps be attributed to the idea that an enzyme that bees add to the nectar produces hydrogen peroxide, an antibacterial agent. For coughs and sore throats, it may be the stickiness and viscosity of honey that makes it work well. It has long been known that demulcents [like honey] can soothe irritated mucous membranes and thereby remove the irritation that is fueling the cough reflex. ...
The Coughing action is a sudden explosion of air from your lungs, which may produce mucus and phlegm. Productive Cough produces phlegm. If you get cold or a flu type of cough, you should not take any medications unless it keeps you awake at night.. Another type of Cough is: unproductive that are dry hacks that irritate your throat. This type of cough appears at the end of the cold or when you have been exposed to an irritant such as smoke or dust. There are 2 types of Cough medications which exist such as Expectorants and Suppressants. The expectorants active ingredients are Quaifenesin, which thins your mucus to make it easier to cough up, something you may also do by drinking plenty of water, tea and fruit juice. While an ingredient Quaifenesin has been approved by the FDA (Food and Drug Administration), its effectiveness ...
When a cough and chest congestion hits, Americans (like me) head to the drugstore, where row upon row of foul-tasting remedies are available. Should you find yourself sick abroad, though, a harsh reality awaits: Cold medicine is hard to come by, and in many countries its simply nonexistent. Thats the case in Bosnia-Herzegovina. But the locals dont need Western-style cough medicine that contains ingredients you cant pronounce (try to say dextromethorphan three times quickly). Theyve got … witchcraft. A first line of defense for a sore throat and cough in this formerly war-torn country is honey. Thats not surprising since "research has proven honey to be just as or more effective in treating coughs than over-the-counter commercial cough syrups," according to Dr. Josh Axe, founder of DrAxe.com, best-selling author of Eat Dirt and co-founder of Ancient Nutrition. Whether ...
Do not take this medicine with any of the following medications: -certain medicines for fungal infections like itraconazole, fluconazole, posaconazole, and voriconazole -cisapride -dextromethorphan; quinidine -dofetilide -dronedarone -pimozide -quinidine -thioridazine -ziprasidone This medicine may also interact with the following medications: -acetazolamide -antihistamines for allergy, cough and cold -atropine -bethanechol -carbamazepine -certain medicines for bladder problems like oxybutynin, tolterodine -certain medicines for Parkinsons disease like benztropine, trihexyphenidyl -certain medicines for stomach problems like dicyclomine, hyoscyamine -certain medicines for travel sickness like scopolamine -cimetidine -dexamethasone -hydrochlorothiazide (HCTZ) -ketamine -ipratropium -metformin -methazolamide -nicotine -NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen -other medicines for Alzheimers disease -other medicines that prolong ...
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19. Bromph DM (Brompheniramine/Dextromethorphan/Pse) Bromph HD (Brompheniramine/Hydrocodone/Pseudoephedrine) Brompheniramine/Carbetapentane/Phenylephrine. Brompheniramine is an antihistamine. brompheniramine/chlorphenirami/methsco/PE/PSE
Medscape - Pseudobulbar affect dosing for Nuedexta dextromethorphan/quinidine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
NUEDEXTA (Quinidine sulfate,Dextromethorphan) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
NUEDEXTA (Quinidine sulfate,Dextromethorphan) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
The Food and Drug Administration (FDA) is concerned about the abuse of dextromethorphan (DXM), a synthetically produced ingredient found in many over-the-counter (OTC) cough and cold remedies. The agency is working with other health and law enforcement authorities to address this serious issue and warn the public of potential harm, after five recently reported deaths of teenagers that may be associated with the consumption of powdered DXM sold in capsules.. Although DXM, when formulated properly and used in small amounts, can be safely used in cough suppressant medicines, abuse of the drug can cause death as well as other serious adverse events such as brain damage, seizure, loss of consciousness, and irregular heart beat.. DXM abuse, though not a new phenomenon, has developed into a disturbing new trend which involves the sale of pure DXM in powdered form. This pure DXM is often encapsulated by the "dealer" and offered for ...
Professional guide for Brompheniramine, Dextromethorphan, and Phenylephrine. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Easy-to-read patient leaflet for Pseudoephedrine, Dexbrompheniramine, Dextromethorphan Liquid. Includes indications, proper use, special instructions, precautions, and possible side effects.
TOPCARE DAY TIME (acetaminophen, dextromethorphan hbr, phenylephrine hcl capsule, liquid filled) can come in different packaging based on the dosage and strength of the medication. Below are pictures of topcare day time packaging to help you recognize it.
The FDA requires all potential medication risks for TOPCARE NITE TIME COLD AND FLU (acetaminophen, dextromethorphan hbr, doxylamine succinate capsule, liquid filled) be disclosed to consumers, no matter how rare. Here are the warnings and precautions for topcare nite time cold and flu.
Sprawdź ile zapłacisz za lek acetaminophen and dextromethorphan w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
Sprawdź ile zapłacisz za lek dextromethorphan/guaifenesin granule packets w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
Acetaminophen is a pain reliever and fever reducer. Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing. Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery...
You should not use this medicine if you have had an allergic reaction to guaifenesin, phenylephrine, or dextromethorphan. You should not use this medicine if you have high blood pressure or heart disease. You should not use this medicine if you are using MAO inhibitors such as Eldepryl®, Marplan®, Nardil®, or Parnate®. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects ...
Terbutaline + acebrophylline + guaifenesin is used in the treatment of asthma.get complete information about terbutaline + acebrophylline + guaifenesin including usage, side effects, drug interaction, expert advice along with medicines associated with terbutaline + acebrophylline + guaifenesin at 1mg.com
This research report scrutinizes the major players in Naphazoline Hydrochloride, Chlorphenamine Maleate and Vitamin B12 Eye Drops market which include Novartis AG, Allergan, Inc., Meda Pharmaceuticals Inc, Bausch & Lomb Inc, Cigna, Similasan Corporation, Visine, Alcon, Viva Opti-Free, Bausch & Lomb, Systane, Rite Aid, Walgreens, Staples, Clear eyes, Refresh, Murine, Tears naturale, Genteal.
The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.. After you begin taking theophylline and guaifenesin combination, it is very important that your doctor check your blood level of theophylline at regular intervals to find out if your dose of theophylline and guaifenesin combination needs to be changed. Do not change your dose of theophylline and guaifenesin combination unless your doctor tells you to do so.. ...
Robitussin (Guaifenesin) es un expectorante. Ayuda a aflojar la congestión en el pecho y la garganta, haciendo así que el tos sale por la boca fácil. Guaifenesin se utiliza para reducir la congestión en el pecho causada por el resfriado común, infecciones o alergias. . Genérico Robitussin (Guaifenesin 200mg) € 1.30 comprimido - Antialérgicas, Antivirales, Tracto Respiratorio @ Canadian online pharmacy. Cheap Canadian online pharmacy
Looking for online definition of scopolamine hydrobromide in the Medical Dictionary? scopolamine hydrobromide explanation free. What is scopolamine hydrobromide? Meaning of scopolamine hydrobromide medical term. What does scopolamine hydrobromide mean?
There are many brands and forms of guaifenesin and phenylephrine available and not all brands are listed on this leaflet. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Phenylephrine is a decongestant that shrinks blood vessels in the...
Buy Ambroxol + Ammonium Chloride + Guaifenesin + Menthol + Terbutaline online at lowest price from India. Find all alternative medicines or Indian brands for generic Ambroxol + Ammonium Chloride + Guaifenesin + Menthol + Terbutaline and inquire online fro
The report generally describes guaifenesin (glyceryl guaiacolate), examines its uses, production methods, patents. Guaifenesin (glyceryl guaiacolate)
Carbetapentane is a cough suppressant. It affects the signals in the brain that trigger cough reflex. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages...
Variations (such as gene duplications) can also result in increased metabolic activity of CYP2D6; these result in an enhanced analgesic response due to the rapid conversion of codeine into morphine. Patients who carry such variations are at risk for opioid toxicity, which includes moderate to severe central nervous system depression. The prevalence of the CYP2D6 ultra-rapid metabolizer phenotype has been estimated at 1-10 percent in Caucasians, 3-5 percent in African Americans, 16-28 percent in North Africans, Ethiopians and Arabs, and up to 21 percent in Asians.3,11 The product labeling (updated in July 2009) of drugs containing codeine include warnings that CYP2D6 ultra-rapid metabolizers "may experience overdose symptoms such as extreme sleepiness, confusion or shallow breathing, even at labeled dosage regimens," and encourages physicians to "choose the lowest effective dose for the shortest period of time and inform their patients about the risks and the signs of morphine overdose."11 Of ...
Everyones favourite health food is currently in season, so nows the best time to get your greens in whilst embracing local, seasonal produce. Although its now pretty easy to get hold of kale year round, buying it whilst in season not only means that it tastes fresher and is better for the environment, but its also cheaper and easier to buy in bulk - perfect for whipping up your daily green juices and salads. Unless youve been living under a rock, Im sure youll be aware that kale has a multitude of benefits, and is currently loved and adored by the health world. Kale is packed full of vitamins A, C and K as well as a huge selection of minerals such as copper and iron. It also has so many uses, and is the perfect base for a salad, as well as green juices, smoothies, kale chips and more adventurous options such as kale granola. Weve put together a few tips on our fave ways to use kale as well as where to find the best kale granola! TIPS:. - When using raw kale in salads or to make kale ...
Guaifenesin syrup is a type of liquid medication that is commonly used for the treatment of cough symptoms. The side effects of...
Sprawdź ile zapłacisz za lek ephedrine/guaifenesin syrup w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
Acetaminophen is a pain reliever and a fever reducer. It is used to treat many conditions, such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth...
Theophylline and guaifenesin combination is used to treat or prevent the symptoms of asthma or to treat chronic bronchitis and emphysema. This medicine relieves cough, wheezing, shortness of breath, and troubled breathing. It works by opening up the bronchial tubes (air passages) of the lungs and increasing the flow of air through them. ...
Sprawdź ile zapłacisz za lek guaifenesin/hydrocodone w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
Buy online best ephedrine supplement with Ephedrine Plus 25mg with 25mg of ephedrine HCL and 200mg of guaifenesin for asthma relief as a bronchodilator at Live Lean Today.
Instructions. Remove stems and chop kale into very thin ribbons; sprinkle with sea salt and gently massage; let rest 15 minutes. The kale will turn a bright green and soften.. Meanwhile in a food processor or blender combine the tomato, tahini or almond butter, garlic and coriander. If your tomato is not super juicy, add a tablespoon or two of water.. In a large saucepan heat a little oil. Add the kale and saute for a minute; then add 1/2 cup or so of water and cover loosely. Let cook 5 to 8 minutes (the fresher the kale the shorter the cook time) until its just wilting but not totally limp. Transfer kale (leave behind any remaining water in the pan) to large bowl.. Meanwhile mix the almond meal and flour in a small bowl. If desired, you could add a little cayenne to this mix too. After it cools enough to handle, add 2/3 of the kale to the blender with the tomato mixture and blend. You dont want it to get too smooth; maybe pulse on and off for a minute or two.. Transfer this blended mix back ...

Cough-medicine alert silences the quackwatchers - tribunedigital-chicagotribuneCough-medicine alert silences the quackwatchers - tribunedigital-chicagotribune

... an ingredient found in more than 100 cough and cold products. At higher-than-recommended doses, teenagers have discovered that ... but they also can lead patients to delay seeking treatment for more serious coughs, including whooping cough, according to the ... state health-care professionals have seen a rise in the number of drug-abuse cases involving dextromethorphan (DXM), ... Cough medicines, unlike homeopathic remedies, are not necessarily harmless. Not only are they ineffective at treating coughs ...
more infohttp://articles.chicagotribune.com/2006-01-22/features/0601220326_1_cough-medicines-over-the-counter-cough-vacation-homes

Content about Cough - Drug Store NewsContent about Cough - Drug Store News

Abuse of the cough ingredient dextromethorphan among high school seniors is down, according to this years Monitoring the ... Cough Boiron on Thursday introduced a new pediatric cough-cold item to its lineup - Childrens Chestal Cold & Cough, a multi- ... Albertsons/Sav-On Pharmacies offering whooping cough vaccination in Southern Calif. As the whooping cough epidemic grows in ... The coming cough-cold season is difficult to project. On one hand, this years cough-cold incidence will be going against very ...
more infohttp://www.drugstorenews.com/topics/Cough

Cough |  Healing Centers | Healing Centers | Healthways, Inc.Cough | Healing Centers | Healing Centers | Healthways, Inc.

... there are coughs and then there are coughs! All coughs, though, are a response by your body to rid itself of something that ... You feel the first type of cough, called bronchitic, deep in your chest. For these coughs, you need an expectorant to help the ... and whooping cough (characterized by a loud gasping cough). Cigarette smoking is one of the main causes of chronic coughing. ... coughs and productive (wet) coughs. The latter expel mucus and usually help speed recovery. (The cough of a cold, for example, ...
more infohttp://www.wholehealthmd.com/main/healing-centers/cough-72.aspx

Cougher | definition of Cougher by Medical dictionaryCougher | definition of Cougher by Medical dictionary

Dextromethorphan, the primary ingredient in many over-the-counter cough remedies, also depresses the brains cough center, but ... whooping cough see whooping cough.. cough. (cawf), 1. A sudden explosive forcing of air through the glottis, occurring ... as is the case with most coughs associated with colds or flu. The two types of drugs used to treat coughs are antitussives and ... cough. (kôf, kŏf). v. coughed, coughing, coughs v.intr.. To expel air from the lungs suddenly and noisily, often to keep the ...
more infohttps://medical-dictionary.thefreedictionary.com/Cougher

Cough Preparations - Obaid.infoCough Preparations - Obaid.info

The combination of dextromethorphan and guaifenesin is used to treat cough and chest congestion caused by the common cold, ... Indications: used in whooping cough, bronchitis, and bronchial catarrh Contraindications: in case of allergy to thyme or any of ... Contraindications: if allergic to any ingredient in Dextromethorphan or taking or have taken a monoamine oxidase (MAO) ... Cough Suppressants. Dextromethorphane:. Indications: Dextromethorphan is a cough suppressant. It works by loosening mucus and ...
more infohttps://www.obaid.info/cough-preparations/

Cold medicine - WikipediaCold medicine - Wikipedia

"New Cough Guidelines Urge Adult Whooping Cough Vaccine; Many OTC Medications Not Recommended for Cough Treatment" (Press ... and diphenhydramine but not better than dextromethorphan for relieving cough symptoms.[23] Honeys use as a cough treatment has ... The original formulation contains the active ingredient pseudoephedrine, but formulations without pseudoephedrine are also ... "Zicam Cold Remedy Nasal Products (Cold Remedy Nasal Gel, Cold Remedy Nasal Swabs, and Cold Remedy Swabs, Kids Size)".. ...
more infohttps://en.wikipedia.org/wiki/Cough_syrup

Throat HealthThroat Health

Pick out a cough medicine. For a dry cough, use an over-the-counter cough suppressant that contains dextromethorphan, Dr. ... 5. Garlic is really valuable herbal remedy for whooping cough. Garlic and onion chicken soup is also an useful home treatment ... Both Triaminic DM and Dimetapp DM have dextromethorphan as their active ingredient. But never use these products if youre ... Avoid cold nutrients because these could worsen the throat more. Beverage hot water. It bequeath afford rest to your septic ...
more infohttp://www.all-home-remedies.com/category/throat-health/

All Home Remedies - Page 2 - All natural treatments to common ailmentsAll Home Remedies - Page 2 - All natural treatments to common ailments

Pick out a cough medicine. For a dry cough, use an over-the-counter cough suppressant that contains dextromethorphan, Dr. ... 5. Garlic is really valuable herbal remedy for whooping cough. Garlic and onion chicken soup is also an useful home treatment ... Both Triaminic DM and Dimetapp DM have dextromethorphan as their active ingredient. But never use these products if youre ... Avoid cold nutrients because these could worsen the throat more. Beverage hot water. It bequeath afford rest to your septic ...
more infohttp://www.all-home-remedies.com/page/2/

Home Health Bronchitis - What is Chronic Bronchitis?Home Health Bronchitis - What is Chronic Bronchitis?

Choose a cough medicine. For a dry cough, try an over-the-counter cough suppressant that contains dextromethorphan, Dr. Simons ... Sometimes the condition is brought on by Wind Cold, which produces a dry cough and whitish mucus. For this type of bronchitis, ... has a relaxation effect on the bronchial tubes which helps in asthma, bronchitis and whooping cough. Its expectorant action ... Both Triaminic DM and Dimetapp DM have dextromethorphan as their active ingredient. But dont use these products if youre ...
more infohttp://bronchitisnatural.info/krii.aspx

COUGH: Causes and Symptoms, Treatment of Cough, Cough PreventionCOUGH: Causes and Symptoms, Treatment of Cough, Cough Prevention

Coughing protects the respiratory system by clearing it of irritants and secretions... ... A cough is a forceful release of air from the lungs that can be heard. ... Dextromethorphan, the primary ingredient in many over-the-counter cough remedies, also depresses the brains cough center, but ... Cough - Prognosis Because the majority of coughs are related to the common cold or influenza, most will end in seven to 21 days ...
more infohttp://www.auuuu.org/respiratory/cough/

Srp 299 have to be frequently connected with the background of thiotepaSrp 299 have to be frequently connected with the background of thiotepa

Analysis component of factors associated with dextromethorphan positive urines demonstrated no significant association with ... The active ingredient or in Broncochem kids allergy control as is dextromethorphan, and there are faking a number of different ... Prophylactic preparation to be honestly used with cruel care infusion for preventing whooping cough and nasal congestion during ... developed an assay to quantitate total and she unbound dextromethorphan in tlie human plasma following Dayquil cold & flu ...
more infohttp://dapoxetinereview.net/how-does-thiotepa-treat-spasticity/625/

basic health: How The Occurrence of Cough Processbasic health: How The Occurrence of Cough Process

... not coughed phlegm can be treated with cough medicine to reduce the cough reflex. Cough pholcodine filters, dextromethorphan ... Cough Can Be Caused by: *Cold, which is a common cause of acute cough which generally within three weeks. ... Bacterial or viral infection in the lungs, for example, acute bronchitis, pneumonia, whooping cough, croup in children. ... Various drugs can contain the same active ingredient (s) and using more than one may cause more than maximum recommended dose ( ...
more infohttp://hipo-health.blogspot.com/2010/08/how-occurrence-of-cough-process.html

Community pharmacy 2010 (final).. pdfCommunity pharmacy 2010 (final).. pdf

The whoop is the sound produced when breathing in after a paroxysm of coughing. • The bouts of coughing prevent normal ... Associated symptoms • A cold, catarrh and a cough may be associated with a sore throat. • There is may also be a fever and ... Dextromethorphan can be given to children of 2 years and over. • Dextromethorphan was generally thought to have a low potential ... Tincture of myrrh has been used in the past as an ingredient of mouthwashes in the treatment of mouth ulcers. - As more ...
more infohttps://www.slideshare.net/PTCnetwork/community-pharmacy-2010final-pdf

Cough Bronchitis - Bronchitis Home Remedies and Bronchitis Chinese MedicineCough Bronchitis - Bronchitis Home Remedies and Bronchitis Chinese Medicine

Both Triaminic DM and Dimetapp DM have dextromethorphan as their active ingredient. But dont use these products if youre ... Avoid people who have colds and coughs. In your present condition, you are highly susceptible to colds and coughs, and it is ... Garlic is a very good remedy for whooping cough.. Bronchitis Bronchitis is the inflammation of the bronchioles of the lungs and ... Choose a cough medicine. For a dry cough, try an over-the-counter cough suppressant that contains dextromethorphan, Dr. Simons ...
more infohttp://bronchitisremedies.info/khif.aspx

Over-the-counter medicines in pregnancy: is it safe to use cough, cold, allergy, constipation or heartburn medicines while...Over-the-counter medicines in pregnancy: is it safe to use cough, cold, allergy, constipation or heartburn medicines while...

... cold and sinus medicines, allergy medicines, constipation medicines, heartburn and indigestion medicines, plus tips on how to ... The cough suppressant dextromethorphan has been in widespread use for many years and is generally considered safe to use during ... so it is important to make sure that each ingredient is safe before taking them. Ask your pharmacist for advice. ... Whooping cough (pertussis) Skin-Like Discharge During Pregnancy: What Is It? Heres exactly what to expect after you take the ...
more infohttps://www.netdoctor.co.uk/conditions/pregnancy-and-family/a9153/over-the-counter-medicines-in-pregnancy/

Follicular Bronchitis - Important Facts about Asthmatic BronchitisFollicular Bronchitis - Important Facts about Asthmatic Bronchitis

Choose a cough medicine. For a dry cough, try an over-the-counter cough suppressant that contains dextromethorphan, Dr. Simons ... Has it ever happened to you to believe that just when you were about to recover from a cold or even the flu an annoying cough ... Both Triaminic DM and Dimetapp DM have dextromethorphan as their active ingredient. But dont use these products if youre ... such as whooping cough which respond to the antibiotic therapy. The treatment is not for a very long time, it lasts for five to ...
more infohttp://whatisbronchitis.info/kimv.aspx

Acute Viral Bronchitis SymptomsAcute Viral Bronchitis Symptoms

The FDA subsequently advocated that cold and cough preparations not be used in children younger than six years. Use of adult ... Other illnesses such as whooping cough can present in an identical way as bronchitis, but have times and different courses when ... Studies have demonstrated that dextromethorphan is not effective for cough suppression in children with bronchitis. These data ... A 2007 review printed in the journal Advances in Experimental Medicine and Biology clarifies the active ingredient in turmeric ...
more infohttp://percyp2.forumotion.com/t138-acute-viral-bronchitis-symptoms

Follicular Bronchitis - Important Facts about Asthmatic BronchitisFollicular Bronchitis - Important Facts about Asthmatic Bronchitis

Choose a cough medicine. For a dry cough, try an over-the-counter cough suppressant that contains dextromethorphan, Dr. Simons ... Sometimes the condition is brought on by Wind Cold, which produces a dry cough and whitish mucus. For this type of bronchitis, ... Both Triaminic DM and Dimetapp DM have dextromethorphan as their active ingredient. But dont use these products if youre ... such as whooping cough which respond to the antibiotic therapy. The treatment is not for a very long time, it lasts for five to ...
more infohttp://bronchitisremedies.info/kimv.aspx

ES2553568T3 -   A pharmaceutical composition rapidly dissolving   - Google PatentsES2553568T3 - A pharmaceutical composition rapidly dissolving - Google Patents

... composition is obtained by subliming solvent from a liquid preparation comprises the pharmaceutically active ingredient, the ... A pharmaceutical composition comprising a carrier matrix of a pharmaceutically active ingredient and comprising inulin as ... whooping cough, polio, tetanus, diphtheria, malaria, cholera, herpes, typhoid fever, HIV, AIDS, Measles, Lyme disease, diarrhea ... the film-coating material may be composed of thermoplastic material with the depressions formed by thermoforming or cold ...
more infohttps://patents.google.com/patent/ES2553568T3/en

Management of cough in adults | European Respiratory SocietyManagement of cough in adults | European Respiratory Society

Acute cough (due to common cold) usually lasts only 2-3 weeks. Various acute infections, (e.g. Mycoplasma pneumoniae and ... Cough syrups, lozenges and drops, and honey share sugar as a common ingredient. Effectiveness, if any, is limited in time to ... In particular, patients with recent contact with persons suffering from acute whooping cough should be checked for antibodies. ... dextromethorphan, dihydrocodeine, noscapine and pentoxyverin). Some nonaddictive herbal remedies (thyme, ribwort and sundew) ...
more infohttps://breathe.ersjournals.com/content/7/2/122

Bronchitis Holistic Treatment - Lobelia Herb Treats Respiratory Problems and MoreBronchitis Holistic Treatment - Lobelia Herb Treats Respiratory Problems and More

Early symptoms of COPD include daily morning coughs with clear sputum. During a cold or other respiratory infection, the cough ... dextromethorphan, and codeine. They will act upon the medullary cough center and will suppress the cough reflex. In case the ... whooping cough, puerperal eclampsia, epilepsy, tetanus, hysterical paraxysms, diphtheria, hysterical convulsions, tonsillitis, ... In fact, it is a main ingredient of many quit smoking treatments. Lobeline acts as a relaxant overall and is used to treat ...
more infohttp://bronchitiscough.info/kcor.aspx

moderator | My CMS | Page 395moderator | My CMS | Page 395

What to know about whooping cough in adults. Whooping cough, or pertussis, is a highly contagious condition. This infection is ... Health Tip: Reducing Asthma Attacks in Cold Weather. (HealthDay News) - Dry, cold air can trigger asthma attacks, the Asthma ... Nuedexta contains a combination of two drugs: dextromethorphan hydrobromide and quinidine sulfate. Dextromethorphan belongs to ... What is Intermezzo? What is zolpidem used for? Intermezzo contains a low dose of zolpidem, the same active ingredient in Ambien ...
more infohttps://www.medicationjunction.com/author/moderator/page/395/

Family Health Online | Family Health Magazine |PHARMACY CARE | Kids and Cold Medications - Young children are better off...Family Health Online | Family Health Magazine |PHARMACY CARE | Kids and Cold Medications - Young children are better off...

Health Canada warned that children under six should not use certain over-the-counter cough and cold medications. This came ... cough suppressant to treat cough (dextromethorphan, diphenhydramine). *expectorant to loosen mucus (guaifenesin). ... Try using extra fluids, more rest and single-ingredient pain relievers to help your child combat a cold. ... Cough and cold medications treat cold symptoms like a runny or stuffy nose, sneezing or cough. Although they have a long ...
more infohttp://familyhealthonline.ca/FHsfwy/fho/pharmacycare/PC_kidsColdMedications_FHc09.asp

dextromethorphan + doxylamine + paracetamol + pseudoephedrine | healthdirectdextromethorphan + doxylamine + paracetamol + pseudoephedrine | healthdirect

More information is available on dextromethorphan + doxylamine + paracetamol + pseudoephedrine including side effects, age ... Dimetapp Cold and Flu Night Relief Liquid Cap. *Dimetapp Cold Cough and Flu Day and Night Liquid Cap ... Active ingredient: dextromethorphan + doxylamine + paracetamol + pseudoephedrine. The medicines below all contain the following ... Conditions Gastroenteritis Skin Conditions Whooping Cough * Symptoms Abdominal Pain Bites and Stings Diarrhoea ...
more infohttps://www.healthdirect.gov.au/medicines/medicinal-product/aht,23846/dextromethorphan-doxylamine-paracetamol-pseudoephedrine
  • According to new guidelines issued by the American College of Chest Physicians, the over-the-counter cough syrups generally contain drugs in too low a dose to be effective or contain combinations of drugs never known to treat coughs. (chicagotribune.com)
  • Not only are they ineffective at treating coughs due to colds, but they also can lead patients to delay seeking treatment for more serious coughs, including whooping cough, according to the college of chest physicians. (chicagotribune.com)
  • You feel the first type of cough, called bronchitic, deep in your chest. (wholehealthmd.com)
  • To assist in the secondary care diagnosis and treatment of chronic cough as the solely presenting symptom if chest radiography and lung function tests remain inconclusive. (ersjournals.com)
  • As many as 84% of Americans want the full array of cough, cold and allergy remedies in the drug store aisles even if they aren't sick at the time. (drugstorenews.com)
  • Cough remedies and self-care measures, such as drinking plenty of fluids and using a humidifier to moisten the air, can make coughs easier to bear and perhaps speed recovery. (wholehealthmd.com)
  • Here is a few simple home remedies for cough that could be easy prepared. (all-home-remedies.com)
  • Are cough and cold remedies safe to take when I'm breastfeeding? (babycenter.com.au)
  • the BEST Chinese medicine and other natural remedies cough that are safe, effective and easily to administer to children. (robinraygreen.com)
  • Instead, it's about combining the right remedies that will work for your child according to their age and the type of cough they have. (robinraygreen.com)
  • As the whooping cough epidemic grows in California, Albertsons/Sav-On Pharmacies throughout Southern California are offering the vaccination to help stop the spread of the highly contagious disease. (drugstorenews.com)
  • In cases where the cough is particularly annoying but not life threatening, a simple cough mixture may be useful. (blogspot.com)
  • The cough reflex is triggered by stimulation of sensory nerves in the lining of the airways - the tubes we use to breathe. (blogspot.com)
  • Coughing usually means there is something in the airways, which should not be there. (blogspot.com)
  • Cough is both an important physiological reflex protecting the airways, and a frequent complaint associated with virtually all pulmonary and several extrapulmonary diseases. (ersjournals.com)
  • On one hand, this year's cough-cold incidence will be going against very strong illness rate numbers from last year. (drugstorenews.com)
  • When a person coughs, shortness of breath and no consumption of the larynx (voice box) is currently closed. (blogspot.com)
  • Pfizer recently launched Robitussin Maximum Strength Cough + Congestion DM, a new liquid-filled capsule that helps control cough on the go. (drugstorenews.com)
  • Many articles on treating kid's cough naturally focus on things you probably already know - like stay hydrated, use a humidifier, cough drops and lemon-honey tea, etc, etc. (robinraygreen.com)