Bethanechol
Parasympathomimetics
Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.
Muscarinic Agonists
Tropicamide
Ageusia
Parasympatholytics
Pentagastrin
Atropine
Receptors, Muscarinic
Muscarinic Antagonists
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Pirenzepine
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Cholinergic Agents
Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.
Receptor, Muscarinic M3
Amylases
Genitalia, Female
Pharmacists
Drug Administration Schedule
Stomach
Parasympathetic Nervous System
The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.
Esophagogastric Junction
Urinary Bladder
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Acetaminophen
Muscle Relaxants, Central
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
Pain
Carcinoma, Pancreatic Ductal
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Muscarinic stimulation of calcium/calmodulin-dependent protein kinase II in isolated rat pancreatic acini. (1/144)
AIM: To study whether M3 receptor occupation would lead to activation of calcium/calmodulin-dependent protein kinase II (CaM kinase II). METHODS: In this study, we isolated rat pancreatic acini by collagenase digestion; measured the Ca2+/calmodulin-independent activity of autophosphorylated form of the CaM kinase II both before and after stimulation of the acini with muscarinic secretagogue bethanechol (Bet). RESULTS: Bet stimulated the activation of, or generation of Ca(2+)-independent activity of, this kinase, in a concentration (0.0001-1 mmol.L-1) and time (5-300 s)-dependent manner; with Bet of 100 mumol.L-1, Ca(2+)-independent activity increased from an unstimulated level of 4.5 +/- 0.3 (n = 4) to 8.9 +/- 1.3 (n = 4, P < 0.05) at 5 s. Another Ca2+ mobilizing secretagogue cholecystokinin (CCK) also activated the kinase; at 1 mumol.L-1, CCK increased Ca(2+)-independent kinase activity to 12.9 +/- 0.5 (n = 6, P < 0.05). Vasoactive intestinal peptide (VIP) at 1 mumol.L-1 did not produce significant Ca(2+)-independent kinase activity (from control 3.90 +/- 0.28 to 4.53 +/- 0.47, n = 6, P > 0.05). Atropine completely blocked Bet activation of the kinase. CONCLUSION: CaM kinase II plays a pivotal role in digestive enzyme secretion, especially during the initial phase of amylase secretion. (+info)Myogenic mechanism for peristalsis in the cat esophagus. (2/144)
A myogenic control system (MCS) is a fundamental determinant of peristalsis in the stomach, small bowel, and colon. In the esophagus, attention has focused on neuronal control, the potential for a MCS receiving less attention. The myogenic properties of the cat esophagus were studied in vitro with and without nerves blocked by 1 microM TTX. Muscle contraction was recorded, while electrical activity was monitored by suction electrodes. Spontaneous, nonperistaltic, electrical, and mechanical activity was seen in the longitudinal muscle and persisted after TTX. Spontaneous circular muscle activity was minimal, and peristalsis was not observed without pharmacological activation. Direct electrical stimulation (ES) in the presence of bethanechol or tetraethylammonium chloride (TEA) produced slow-wave oscillations and spike potentials accompanying smooth muscle contraction that progressed along the esophagus. Increased concentrations of either drug in the presence of TTX produced slow waves and spike discharges, accompanied by peristalsis in 5 of 8 TEA- and 2 of 11 bethanechol-stimulated preparations without ES. Depolarization of the muscle by increasing K(+) concentration also produced slow waves but no peristalsis. We conclude that the MCS in the esophagus requires specific activation and is manifest by slow-wave oscillations of the membrane potential, which appear to be necessary, but are not sufficient for myogenic peristalsis. In vivo, additional control mechanisms are likely supplied by nerves. (+info)Cholinergic effects on human gastric motility. (3/144)
BACKGROUND: Cholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated. AIMS: To determine the effects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility. METHODS: Ten normal subjects underwent three studies each, using simultaneous electrogastrography (EGG), antroduodenal manometry, and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of baseline fasting manometry and EGG, subjects received saline intravenously, atropine (0.6 mg then 0.25 mg/hour intravenously), or bethanechol (5 mg subcutaneously). This was followed by another 30 minutes' recording and by three hours of postprandial recording after ingestion of a technetium-99m labelled solid meal. RESULTS: During fasting, atropine decreased, whereas bethanechol increased, the antral manometric motility index and EGG power. Postprandially, atropine decreased the amplitude of antral contractions by DAS, decreased the postprandial antral manometric motility index, and slowed gastric emptying. Atropine caused a slight increase in postprandial frequency of antral contractions by DAS and gastric myoelectrical activity by EGG. Bethanechol slightly increased the amplitude, but slightly decreased the frequency of antral contractions by DAS and decreased the frequency of gastric myoelectrical activity by EGG, with no significant increase in the motility index or gastric emptying. CONCLUSIONS: Cholinergic antagonism with atropine reduces antral contractility and slows gastric emptying. Cholinergic stimulation with bethanechol increases antral contractility, but decreases the frequency of antral contractions, without altering the antral motility index or gastric emptying. (+info)Time course of isolated rat fundus response to muscarinic agonists: a measure of intrinsic efficacy. (4/144)
The establishment of a dose-response relationship and its quantification is the usual procedure for analysing drug action on an isolated organ. However, the time course of the effect seems to be an inherent characteristic of the agonist which produces it. In our study, we have analyzed the time-response curves of four cholinergic agonists (acetylcholine, methacholine, carbachol and bethanechol) which produce tonic contractions of the isolated rat gastric fundus. The order of affinity of agonists to muscarinic receptors on the rat fundus were carbachol > bethanechol > methacholine > acetylcholine (K(A) values: 46 +/- 12, 84 +/- 21, 380 +/- 110 and 730 +/- 120 nM, respectively). The effective concentrations which produced 60% of the maximal response (EC60) were used for establishing the time-response curves. The time-response curves were also recorded after partial alkylation of muscarinic receptors with phenoxybenzamine, after exposure of the isolated rat fundus to physostigmine and after addition of supramaximal concentrations of the agonists. The experimental time-response curve for acetylcholine was on the extreme left, followed by curves for methacholine, bethanechol and carbachol, respectively. Phenoxybenzamine and supramaximal doses of the agonists did not change the order of response development in time, but supramaximal doses shifted all curves to the left and phenoxybenzamine shifted all time-response curves to the right. Only physostigmine shifted the time-response curve for methacholine to the right. The results of our study suggest that the response rate of the isolated rat gastric fundus to cholinergic agonists depends on the intrinsic activity of these agents, but not on their affinity for muscarinic receptors. (+info)Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. (5/144)
BACKGROUND: Topical nitrates lower anal sphincter pressure and heal anal fissures, but a majority of patients experience headache. The internal anal sphincter has a calcium dependent mechanism to maintain tone, and also receives an inhibitory extrinsic cholinergic innervation. It may therefore be possible to lower anal sphincter pressure using calcium channel blockers and cholinergic agonists without side effects. AIMS: To investigate the effect of oral and topical calcium channel blockade and a topical cholinomimetic on anal sphincter pressure. METHODS: Three studies were conducted, each involving 10 healthy volunteers. In the first study subjects were given oral 60 mg diltiazem or placebo on separate occasions. They were then given diltiazem once or twice daily for four days. In the second and third studies diltiazem and bethanechol gels of increasing concentration were applied topically to lower anal pressure. RESULTS: A single dose of 60 mg diltiazem lowered the maximum resting anal sphincter pressure (MRP) by a mean of 21%. Once daily diltiazem produced a clinically insignificant effect but a twice daily regimen reduced anal pressure by a mean of 17%. Diltiazem and bethanechol gel produced a dose dependent reduction of the anal pressure; 2% diltiazem produced a maximal 28% reduction, and 0.1% bethanechol a maximal 24% reduction, the effect lasting three to five hours. CONCLUSIONS: Topical diltiazem and bethanechol substantially reduce anal sphincter pressure for a prolonged period, and represent potential low side effect alternatives to topical nitrates for the treatment of anal fissures. (+info)Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling. I. Use of chlorotetracycline as fluorescent probe. (6/144)
Stimulus-secretion coupling in pancreatic exocrine cells was studied using dissociated acini, prepared from mouse pancreas, and chlorotetracycline (CTC), a fluorescent probe which forms highly fluorescent complexes with Ca2+ and Mg2+ ions bound to membranes. Acini, preloaded by incubation with CTC (100 microM), displayed a fluorescence having spectral properties like that of CTC complexed to calcium (excitation and emission maxima at 398 and 527 nm, respectively). Stimulation with either bethanechol or caerulein resulted in a rapid loss of fluorescence intensity and an increase in outflux of CTC from the acini. After 5 min of stimulation, acini fluorescence had been reduced by 40% and appeared to be that of CTC complexed to Mg2+ (excitation and emission maxima at 393 and 521 nm, respectively). The fluorescence loss induced by bethanechol was blocked by atropine and was seen at all agonist concentrations that elicited amylase release. Maximal fluorescence loss, however, required a bethanechol concentration three times greater than that needed for maximal amylase release. In contrast, acini preloaded with ANS or oxytetracycline, probes that are relatively insensitive to membrane-bound divalent cations, displayed no secretagogue-induced fluorescence changes. These results are consistent with the hypothesis that CTC is able to probe some set of intracellular membranes which release calcium during secretory stimulation and that this release results in dissociation of Ca(2+)-complexed CTC. (+info)Signaling mechanisms for muscarinic receptor-mediated coronary vasoconstriction in isolated rat hearts. (7/144)
Signaling mechanisms for muscarinic receptor-mediated vasoconstriction in coronary resistance arteries were studied in potassium-arrested isolated rat hearts perfused at a constant flow rate. The cholinergic agonist bethanechol was given by bolus injection or constant infusion. Perfusion pressure was monitored as an indicator of coronary vascular resistance. Bolus injection of bethanechol evoked a phasic vasoconstriction in a dose-dependent manner, whereas infusion of bethanechol evoked a tonic vasoconstriction without producing tachyphylaxis. Bethanechol-induced phasic vasoconstriction was eliminated by perfusion with a Ca(2+)-free buffer. The L-type voltage-operated Ca(2+) channel blocker nifedipine decreased the maximal constrictor response to bethanechol by 59 +/- 2% (n = 4, P <.001), whereas the putative receptor-operated Ca(2+) channel blocker SK&F 96365 converted this vasoconstriction into vasodilation that was not mediated by nitric oxide. The protein kinase C inhibitor chelerythrine reduced the maximal phasic vasoconstrictor response to bethanechol by 78 +/- 2% (n = 6, P <.001) Bethanechol-induced tonic vasoconstriction was rapidly converted to a sustained vasodilation during infusion of SK&F 96365 or nifedipine, whereas infusion of chelerythrine gradually attenuated the tonic response to bethanechol. Results from other experiments do not support a role for phospholipase A(2)-dependent mediators in generating coronary vasoconstrictor responses to bethanechol. It is concluded that voltage-independent receptor-operated Ca(2+) channels, voltage-operated Ca(2+) channels, and protein kinase C are major signaling components for muscarinic receptor-mediated contraction of rat coronary resistance arteries. (+info)Parasympathetic non-adrenergic, non-cholinergic-induced protein synthesis and mitogenic activity in rat parotid glands. (8/144)
Electrical stimulation of the parasympathetic auriculo-temporal nerve (40 Hz, 30 min), in the anaesthetized rat under - and -adrenoceptor blockade, increased [3H]thymidine and [3H]leucine uptake into the parotid glands by 80 and 263 %, respectively. The increase in response to parasympathetic stimulation was almost the same ([3H]thymidine 82 % and [3H]leucine 283 %) when atropine (2 mg kg-1 I.P. or I.V.) was included in the pretreatment. Neither intravenous infusion of vasoactive intestinal peptide (0.5-20 mg kg-1 min-1, 30 min) nor of bethanechol (10 mg kg-1 min-1, 30 min), under adrenoceptor blockade, increased the uptake of [3H]thymidine into the glands. However, these drugs increased [3H]leucine uptake, and in combination they interacted positively. Whereas vasoactive intestinal peptide is likely to be involved in the parasympathetic nerve-evoked protein synthesis, the nature of the non-adrenergic, non-cholinergic component(s) involved in the mitogenic response is presently unknown. (+info)
What is most likely to occur? After administering bethanechol to a - ProProfs Discuss
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Autonomic drug
Bethanechol is a muscarinic agonist. It is included in the therapy for underactive bladder with poor contraction of detrusor ... A low dose of Bethanechol is often used in treatment as increasing the dose can cause side effects like nausea, diarrhea and ... Since contraction of detrusor muscle in the bladder is controlled by the parasympathetic nervous system, Bethanechol can bind ...
Margatoxin
Upon activation of muscarinic ACh receptors with bethanechol, margatoxin-sensitive current was suppressed. Therefore, it was ...
Dimethylphenylpiperazinium
Phenylpiperazine Prado WA, Segalla DK (August 2004). "Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in ...
Alpha-3 beta-4 nicotinic receptor
Prado WA, Segalla DK (2004). "Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or ...
Anal fissure
Carapeti, E.; Kamm, M.; Phillips, R. (2000). "Topical Diltiazem and Bethanechol Decrease Anal Sphincter Pressure and Heal Anal ...
Neurogenic bladder dysfunction
For urinary retention, cholinergics (muscarinic agonists) like bethanechol can improve the squeezing ability of the bladder. ...
Betanehol - Википедија, слободна енциклопедија
Carter WJ (2008). „Unexpected benefits of bethanechol in adults with cerebral palsy". Med. J. Aust. 189 (5): 293. PMID 18759732 ...
Equine proximal enteritis
Prokinetic drugs such as lidocaine, erythromycin, metoclopramide, and bethanechol are often used to treat the ileus associated ...
Pilocarpine
Bethanechol-a similar muscarinic parasympathomimetic with longer lasting effect "Pilocarpine". The American Society of Health- ...
Underactive bladder
Treatment frequently includes lifestyle modification (fluid restriction, bladder retraining). Bethanechol is a prescription ... medication used for treatment, bethanechol can stimulate the nerves of the bladder, making them more responsive to stimulus. ...
Overflow incontinence
Medications Bethanechol (Management of overflow incontinence by activating muscarinic receptors in the bladder and stimulating ...
Methoctramine
... such as bethanechol or berberine). At higher concentrations, allosteric properties of methoctramine have also been described. ...
Said Awad
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Cevimeline
Bethanechol - a similar muscarinic parasympathomimetic with longer-lasting effect Ono M, Takamura E, Shinozaki K, et al. (July ...
Megacolon
Bethanechol can also be used to treat megacolon by means of its direct cholinergic action and its stimulation of muscarinic ...
Trimethyl ammonium compounds
Examples include: Betaine Bethanechol Carnitine and its derivatives Choline and its derivatives Methacholine Muscarine ...
Parasympathomimetic drug
Choline esters Acetylcholine (all acetylcholine receptors) Bethanechol (M3 receptors) Carbachol (all muscarinic receptors and ...
List of veterinary drugs
... chronic kidney failure and protein-losing nephropathy bethanechol - stimulates bladder contractions, tranquilizer, makes the ...
Muscarinic acetylcholine receptor M3
acetylcholine bethanechol carbachol L-689,660 (mixed M1/M3 agonist) oxotremorine pilocarpine (in eye) atropine hyoscyamine ...
Peripherally selective drug
L-amino acid decarboxylase inhibitor used in combination with levodopa in the treatment of Parkinson's disease Bethanechol - a ...
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ATC code N07
... combinations N07AB01 Carbachol N07AB02 Bethanechol N07AX01 Pilocarpine N07AX02 Choline alfoscerate N07AX03 Cevimeline N07BA01 ...
Bethanechol
The name bethanechol refers to its structure as the urethane of beta-methylcholine. Bethanechol alleviates dry mouth and is ... Bethanechol should be used to treat these disorders only after mechanical obstruction is ruled out as a possible cause. Its ... Use of bethanechol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary ... Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action. ...
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"Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants". The American Journal of Psychiatry ...
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Fesoterodine
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The name bethanechol refers to its structure as the urethane of beta-methylcholine. Bethanechol alleviates dry mouth and is ... Bethanechol should be used to treat these disorders only after mechanical obstruction is ruled out as a possible cause. Its ... Use of bethanechol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary ... Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action. ...
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No information is available on the use of bethanechol during breastfeeding. If it is used during breastfeeding, monitor the ... Bethanechol - Drugs and Lactation Database (LactMed). Bethanechol - Drugs and Lactation Database (LactMed). ... No information is available on the use of bethanechol during breastfeeding. If it is used during breastfeeding, monitor the ... Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Bethanechol. [ ...
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bethanechol synonyms, bethanechol pronunciation, bethanechol translation, English dictionary definition of bethanechol. n. A ... bethanechol. Also found in: Medical, Wikipedia.. Related to bethanechol: Bethanechol chloride. be·than·e·chol. (bĕ-thăn′ĭ-kôl ... Bethanechol - definition of bethanechol by The Free Dictionary https://www.thefreedictionary.com/bethanechol ... Bethanechol is a cholinergic agent used to treat urinary retention related to bladder atony.. Getting Ready for Certification: ...
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BETHANECHOL CHLORIDE tablet. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader application. ... Bethanechol Chloride Tablets, USP 5 mg tablets are white, 7/16" diameter, round flat faced bevel edge tablets; one side scored ... BETHANECHOL CHLORIDE tablet. If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be ... Bethanechol chloride tablets should preferably be taken one hour before or two hours after meals to avoid nausea or vomiting. ...
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BETHANECHOL CHLORIDE tablet. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader application. ... BETHANECHOL CHLORIDE tablet. If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be ... Bethanechol chloride tablets should preferably be taken one hour before or two hours after meals to avoid nausea or vomiting. ... Bethanechol chloride does not cross the blood-brain barrier because of its charged quaternary amine moiety. The metabolic rate ...
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A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone ... Bethanechol is a synthetic ester structurally and pharmacologically related to acetylcholine. ... Bethanechol. Accession Number. DB01019 (APRD00051) Type. Small Molecule. Groups. Approved. Description. Bethanechol is a ... Bethanechol Chloride. Tablet. 25 mg/1. Oral. Lake Erie Medical DBAQuality Care Products LLC. 2015-08-06. 2016-06-01. US. ...
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UrecholineBladderTabletDuvoid25MGTabletsName bethanecholCholinergic agentUrinary retentionPilocarpineUnusual or allergic reaction to bethanecholAgonistAnal sphincter pressureMedicationDrugsContraindicationsAdministration of bethanechol2018Take bethanecholAustralia bethanecholDosesPharmacologyParasympathetic nervouPrescriptionOralMotilityNicotinicDetrusorSalivationSide effectsUrineStimulationSurgerySyntheticHydrolyzed by cholinesteraseDosePrecautionsMuscarinic receptorCross the blood-brain bNauseaDiltiazemCause dizzinessInabilityParasympathomimeticHttpsObstructionGenericPillMedicines
Urecholine9
- Bethanechol is sold under the brand names Duvoid (Roberts), Myotonachol (Glenwood), Urecholine (Merck Frosst) and Urocarb (Hamilton). (wikipedia.org)
- The cholinergics oral bethanechol (such as Urecholine) [C] and injectable neostigmine (Prostigmin) [C] are used for urinary retention, and bethanechol is used for postpartum nonobstructive urinary retention. (thefreedictionary.com)
- The lowest price for Bethanechol chloride (Urecholine) 5 MG is found at local U.S. pharmacies. (pharmacychecker.com)
- Urecholine (bethanechol) is a small molecule pharmaceutical. (biometadata.com)
- Bethanechol was first approved as Urecholine on 1982-01-01. (biometadata.com)
- bethanechol prices south africa buy can i buy urecholine at a local drug store buy bethanechol 25 mg identification so here is some information to help. (aircus.com)
- What is the most important information I should know about Urecholine (bethanechol)? (worthmeds.com)
- What should I discuss with my healthcare provider before taking Urecholine (bethanechol)? (worthmeds.com)
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Bladder20
- Atropine is given preoperatively to prevent voiding of the bowel/bladder during surgery, Bethanechol is then given postoperatively to revert this action. (wikipedia.org)
- Bethanechol is a cholinergic agent used to treat urinary retention related to bladder atony. (thefreedictionary.com)
- 23-24, July 1977) was conducted on the relative effectiveness of oral and subcutaneous doses of bethanechol chloride on the stretch response of bladder muscle in patients with urinary retention. (nih.gov)
- Bethanechol chloride is indicated for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. (nih.gov)
- Bethanechol stimulates your bladder to empty. (cigna.com)
- Bethanechol is taken to treat certain disorders of the urinary tract or bladder. (drugs.com)
- If your dog has problems emptying their bladder, then your veterinarian may prescribe Bethanechol 25 mg, 100 Tablets. (vetdepot.com)
- Bethanechol 50 mg, 100 Tablets is a prescription medication used to increase the strength of bladder contractions. (vetdepot.com)
- Bethanechol works by increasing the tone of the detrusor muscle in the bladder. (proprofs.com)
- Bethanechol use is contraindicated when the strength or integrity of the gastrointestinal or bladder wall is questionable. (pdr.net)
- Bethanechol belongs to a group of drugs called cholinergic agents, which help muscles work to empty urine from the bladder. (rxwiki.com)
- Uses/Indications - In veterinary medicine, bethanechol is used primarily to stimulate bladder contractions in small animals. (elephantcare.org)
- BETHANECHOL (be THAN e kole) stimulates the bladder. (yourcareeverywhere.com)
- Bethanechol stimulates the detrusor muscle of the bladder, promoting mictruition. (pathwaymedicine.org)
- Consequently, bethanechol has been used to treat atonic bladder, potentially as a result of neurogenic bladder. (pathwaymedicine.org)
- Bethanechol is prescribed to treat problems with urination due to nerve problems in the bladder, or weakness in certain bladder muscles. (californiapetpharmacy.com)
- Bethanechol is useful in treating bladder atony which occur in post operative period or post partum. (medicalzone.net)
- Bethanechol will stimulates the M3 receptors which cause an increase in contraction of the bladder with relaxation of the sphincter of the bladder. (medicalzone.net)
- In urinary retention, if the sphincter fails to relax as bethanechol contracts the bladder, urine may be forced up the ureter into the kidney pelvis. (medlibrary.org)
- Since contraction of detrusor muscle in the bladder is controlled by the parasympathetic nervous system, Bethanechol can bind to muscarinic receptors to stimulate activation of the parasympathetic nervous system and restore contraction of detrusor muscle. (wikipedia.org)
Tablet4
- Bethanechol comes as a tablet to take by mouth. (medlineplus.gov)
- Each tablet for oral administration contains 5 mg, 10 mg, 25 mg or 50 mg bethanechol chloride, USP. (nih.gov)
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Duvoid1
- Prokinetic agents include metoclopramide (also known as Reglan), bethanechol (Duvoid) and tegaserod (Zelnorm). (thefreedictionary.com)
25MG1
- Purchase Bethanechol 25mg Online. (aircus.com)
Tablets2
- Storage/Stability/Compatibility - Bethanechol tablets should be stored at room temperature in tight containers. (elephantcare.org)
- To ascertain how elevation of the head of the bed, bethanechol, and antacid foam tablets affect gastroesophageal reflux, we used prolonged intraesophageal pH monitoring in 55 symptomatic patients. (gerdhelp.com)
Name bethanechol1
- The name bethanechol refers to its structure as the urethane of beta-methylcholine. (wikipedia.org)
Cholinergic agent3
- Bethanechol chloride, USP, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. (nih.gov)
- Bethanechol is a cholinergic agent that stimulates the parasympathetic nervous system. (ons.org)
- Bethanechol is a powerful cholinergic agent. (medindia.net)
Urinary retention4
- Consider a trial of a cholinergic agonist, such as bethanechol , in patients with urinary retention. (thefreedictionary.com)
- Bethanechol is used to treat urinary retention (difficulty urinating), which may occur after surgery, after delivering a baby, and in other situations. (cigna.com)
- A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. (drugbank.ca)
- Bethanechol is used to treat urinary retention (difficulty passing urine) caused by surgery, drugs or other factors. (singhealth.com.sg)
Pilocarpine1
- 15. The method of claim 14, wherein the muscarinic agonist is selected from the group consisting of pilocarpine, isopilocarpine lactam, carbachol, bethanechol, methacholine and muscarine. (freepatentsonline.com)
Unusual or allergic reaction to bethanechol1
- Tell your doctor if you have ever had any unusual or allergic reaction to bethanechol or any other medicines. (drugs.com)
Agonist6
- The second approach is to attempt to correct the lysosomal defect by a cholinergic agonist, bethanechol chloride. (thefreedictionary.com)
- Bethanechol is a cholinergic agonist drug that stimulates muscarinic receptors. (proprofs.com)
- Bethanechol Chloride is an agonist selective for Muscarinic Acetylcholine Receptors with no effect on nicotinic receptors. (emdmillipore.com)
- Bethanechol is a synthetic direct-acting cholinergic agonist with a specificity for muscarinic receptors . (pathwaymedicine.org)
- Bethanechol Chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors. (ebiochemicals.com)
- Bethanechol is a muscarinic agonist. (wikipedia.org)
Anal sphincter pressure3
- Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. (thefreedictionary.com)
- Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects. (thefreedictionary.com)
- CONCLUSIONS Topical diltiazem and bethanechol substantially reduce anal sphincter pressure for a prolonged period, and represent potential low side effect alternatives to topical nitrates for the treatment of anal fissures. (bmj.com)
Medication2
- Bethanechol may also be used for purposes other than those listed in this medication guide. (cigna.com)
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Drugs4
- Bethanechol is used to relieve difficulties in urinating caused by surgery, drugs, or other factors. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to bethanechol or any other drugs. (medlineplus.gov)
- Using bethanechol with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (drugs.com)
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Contraindications1
- BETHANECHOL CHLORIDE - RobHolland In Bethanechol - Uses, Reviews, Side-effects, and Contraindications the growing practice. (daralrahmah.co.uk)
Administration of bethanechol2
- Effects on the GI and urinary tracts sometimes appear within 30 minutes after oral administration of bethanechol chloride, but more often 60 to 90 minutes are required to reach maximum effectiveness. (nih.gov)
- After subcutaneous administration of bethanechol, the patient should be observed for 30 minutes to 1 hour for possible severe reactions, and a syringe containing a dose of atropine should be immediately available to promptly counteract adverse effects. (pdr.net)
20182
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Take bethanechol6
- Take bethanechol exactly as directed. (medlineplus.gov)
- Take bethanechol on an empty stomach 1 hour before or 2 hours after meals to prevent nausea and vomiting. (cigna.com)
- You may not be able to take bethanechol, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. (cigna.com)
- How should I take bethanechol? (cigna.com)
- Take bethanechol on an empty stomach (either 1 hour before or 2 hours after meals) to lessen the possibility of nausea and vomiting, unless otherwise directed by your doctor. (drugs.com)
- What food or medicine must I avoid when I take Bethanechol? (singhealth.com.sg)
Australia bethanechol1
- Function texas can reduce australia bethanechol for sale, while diseases are prescribed for obliteration. (discoverhoustontours.com)
Doses5
- Following oral administration, the usual duration of action of bethanechol chloride is one hour, although large doses (300 to 400 mg) have been reported to produce effects for up to six hours. (nih.gov)
- Because of the selective action of bethanechol chloride, nicotinic symptoms of cholinergic stimulation are usually absent or minimal when orally or subcutaneously administered in therapeutic doses, while muscarinic effects are prominent. (nih.gov)
- The following information includes only the average doses of bethanechol. (drugs.com)
- In high doses, bethanechol can also cause a decrease in cardiac contractions. (proprofs.com)
- With high doses of bethanechol, cardiovascular responses may include vasodilation, decreased cardiac rate, and decreased force of cardiac contraction, which may cause hypotension. (proprofs.com)
Pharmacology1
- Pharmacology - Bethanechol directly stimulates cholinergic receptors. (elephantcare.org)
Parasympathetic nervou1
- Bethanechol chloride acts principally by producing the effects of stimulation of the parasympathetic nervous system. (nih.gov)
Prescription2
- Bethanechol is available only with your doctor's prescription. (drugs.com)
- As the disease advances children may experience mental impairment, buy bethanechol online uk no prescription The doctor tells you that you are going to have to start self monitoring your blood sugar levels at home. (aircus.com)
Oral2
- In humans, bethanechol is poorly absorbed from the GI tract, and the onset of action is usually within 30-90 minutes after oral dosing. (elephantcare.org)
- bethanechol chloride oral : User Ratin. (druginformer.com)
Motility1
- Bethanechol enhances GI Motility . (pathwaymedicine.org)
Nicotinic1
- Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. (wikipedia.org)
Detrusor1
- arrow] increased Bethanechol * tone and contrac- tion of detrusor. (thefreedictionary.com)
Salivation2
- Symptoms of a bethanechol overdose include abdominal discomfort, increased salivation or watering mouth, flushing or hot feeling of the skin, sweating, nausea, and vomiting. (cigna.com)
- The side effects of bethanechol may include diarrhea, salivation and sweating due to activation of the M3 receptor while bradycardia due to activation of the M2 receptor. (medicalzone.net)
Side effects9
- Bethanechol may cause side effects. (medlineplus.gov)
- What are the possible side effects of bethanechol? (cigna.com)
- Although there is no specific information comparing use of bethanechol in children with use in other age groups, bethanechol is not expected to cause different side effects or problems in children than it does in adults. (drugs.com)
- Therefore, patients taking bethanechol for urine retention may manifest side effects such as nausea and vomiting. (proprofs.com)
- Common side effects of bethanechol include general discomfort, upset stomach, and dizziness. (rxwiki.com)
- Serious side effects have been reported with bethanechol. (rxwiki.com)
- This is not a complete list of bethanechol side effects. (rxwiki.com)
- What side effects can Bethanechol cause? (singhealth.com.sg)
- A low dose of Bethanechol is often used in treatment as increasing the dose can cause side effects like nausea, diarrhea and headache. (wikipedia.org)
Urine1
- After administering bethanechol to a patient with urine retention, the nurse in charge monitors the patient for adverse effects. (proprofs.com)
Stimulation1
- Since bethanechol is a muscarinic receptor stimulator, other effects of muscarinic stimulation will occur. (proprofs.com)
Surgery2
- Bethanechol chloride is also used by people who have trouble urinating after surgery or after delivering a baby. (medbroadcast.com)
- Bethanechol is contraindicated in patients who are allergic to the drug, with history of asthma, peptic ulcer, intestinal or urinary obstruction, following recent gastrointestinal or urinary surgery, decreased heart rate and low blood pressure, epilepsy, Parkinsonism, coronary heart disease and overactive thyroid. (medindia.net)
Synthetic2
- Chemistry - A synthetic cholinergic ester, bethanechol occurs as a slightly hygroscopic, white or colorless crystalline powder with a slight, amine-like or "fishy" odor. (elephantcare.org)
- Bethanechol is a synthetic muscarinic stimulant. (medscape.com)
Hydrolyzed by cholinesterase1
- Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action. (wikipedia.org)
Dose1
- The dose of bethanechol will be different for different patients. (drugs.com)
Precautions1
- Before taking Bethanechol, what precautions must I follow? (singhealth.com.sg)
Muscarinic receptor1
- Use of bethanechol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, peptic ulcers, intestinal obstruction and hyperthyroidism. (wikipedia.org)
Cross the blood-brain b2
- Bethanechol chloride does not cross the blood-brain barrier because of its charged quaternary amine moiety. (nih.gov)
- Bethanechol will not react with muscarinic 1 receptor (M1) on the central nervous system due to bethanechol inability to cross the blood brain barrier. (medicalzone.net)
Nausea1
- Administer bethanechol on an empty stomach (i.e., 1 hour before or 2 hours after a meal) to minimize nausea and vomiting. (pdr.net)
Diltiazem2
Cause dizziness2
Inability1
- inability to sleep or sleeping too much, buy bethanechol bars cheap cheap bethanechol online without rx remove residue buildup around the base of the hair, This article will tell you more about it. (aircus.com)
Parasympathomimetic1
- Bethanechol is a parasympathomimetic choline ester, a drug that has a stimulating effect on muscarinic receptors which are responsible for the contraction of the smooth muscle tone. (medicalook.com)
Https2
- https://www.ema.europa.eu/documents/psusa/bethanechol-list-nationally-authorised-medicinal-products-psusa/00000402/202006_en.pdf Gorsky M, Epstein JB, Parry J, Epstein MS, Le ND, Silverman S (February 2004). (wikipedia.org)
- 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547017/6/Bethanechol. (hopkinsguides.com)
Obstruction1
- Bethanechol should be used to treat these disorders only after mechanical obstruction is ruled out as a possible cause. (wikipedia.org)
Generic11
- The generic ingredient in BETHANECHOL CHLORIDE is bethanechol chloride . (drugpatentwatch.com)
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Medicines1
- When you are taking bethanechol, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. (drugs.com)