A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
The L-Isomer of bunolol.
A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.
A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
An aspartate aminotransferase found in MITOCHONDRIA.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
Unstable isotopes of sodium that decay or disintegrate emitting radiation. Na atoms with atomic weights 20-22 and 24-26 are radioactive sodium isotopes.
Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The pressure of the fluids in the eye.
The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Techniques for measuring blood pressure.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Method in which repeated blood pressure readings are made while the patient undergoes normal daily activities. It allows quantitative analysis of the high blood pressure load over time, can help distinguish between types of HYPERTENSION, and can assess the effectiveness of antihypertensive therapy.
Techniques for standardizing and expediting taxonomic identification or classification of organisms that are based on deciphering the sequence of one or a few regions of DNA known as the "DNA barcode".
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
Computer systems or networks designed to provide radiographic interpretive information.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Agents that promote the excretion of urine through their effects on kidney function.
A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
The mulberry plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. They have milky latex and small, petalless male or female flowers.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Interventions to provide care prior to, during, and immediately after surgery.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.
Insects of the family Formicidae, very common and widespread, probably the most successful of all the insect groups. All ants are social insects, and most colonies contain three castes, queens, males, and workers. Their habits are often very elaborate and a great many studies have been made of ant behavior. Ants produce a number of secretions that function in offense, defense, and communication. (From Borror, et al., An Introduction to the Study of Insects, 4th ed, p676)
The fertilizing element of plants that contains the male GAMETOPHYTES.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
Persons functioning as natural, adoptive, or substitute parents. The heading includes the concept of parenthood as well as preparation for becoming a parent.
Venoms from the superfamily Formicoidea, Ants. They may contain protein factors and toxins, histamine, enzymes, and alkaloids and are often allergenic or immunogenic.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors. (1/69)

(-)-Pindolol, which possesses significant affinity for 5-HT1A, 5-HT1B, and beta 1/2-adrenergic receptors (AR)s, dose-dependently increased extracellular levels of dopamine (DA) and noradrenaline (NAD) versus 5-HT, in dialysates of the frontal cortex (FCX), but not accumbens and striatum, of freely-moving rats. In distinction, the preferential beta 1-AR antagonist, betaxolol, and the preferential beta 2-AR antagonist, ICI118,551, did not increase basal levels of DA, NAD, or 5-HT. Further, they both dose-dependently and markedly blunted the influence of (-)-pindolol upon DA and NAD levels. The selective 5-HT1A receptor antagonist, WAY100,635, slightly attenuated the (-)-pindolol-induced increase in DA and NAD levels, while the selective 5-HT1B antagonist, SB224,289, was ineffective. These data suggest that (-)-pindolol facilitates frontocortical dopaminergic (and adrenergic) transmission primarily by activation of beta 1/2-ARs and, to a lesser degree, by stimulation of 5-HT1A receptors, whereas 5-HT1B receptors are not involved. (-)-Pindolol potentiated the increase in FCX levels of 5-HT elicited by the 5-HT reuptake inhibitors, fluoxetine and duloxetine, and also enhanced their ability to elevate FCX levels of DA--though not of NAD. In contrast to (-)-pindolol, betaxolol and ICI118,551 did not affect the actions of fluoxetine, whereas both WAY100,635 and SB224,289 potentiated the increase in levels of 5-HT--but not DA or NAD levels--elicited by fluoxetine. In conclusion, (-)-pindolol modulates, both alone and together with 5-HT reuptake inhibitors, dopaminergic, adrenergic, and serotonergic transmission in the FCX via a complex pattern of actions at beta 1/2-ARs, 5-HT1A, and 5-HT1B receptors. These findings have important implications for clinical studies of the influence of (-)-pindolol upon the actions of antidepressant agents.  (+info)

Constitutively active mutants of the beta1-adrenergic receptor. (2/69)

We provide the first evidence that point mutations can constitutively activate the beta(1)-adrenergic receptor (AR). Leucine 322 of the beta(1)-AR in the C-terminal portion of its third intracellular loop was replaced with seven amino acids (I, T, E, F, C, A and K) differing in their physico-chemical properties. The beta(1)-AR mutants expressed in HEK-293 cells displayed various levels of constitutive activity which could be partially inhibited by some beta-blockers. The results of this study might have interesting implications for future studies aiming at elucidating the activation process of the beta(1)-AR as well as the mechanism of action of beta-blockers.  (+info)

Effects of betaxolol on light responses and membrane conductance in retinal ganglion cells. (3/69)

PURPOSE: To examine the physiological effects of betaxolol, a beta1-adrenergic receptor blocker commonly used in the treatment of glaucoma, on retinal ganglion cells and to evaluate its potential to elicit responses consistent with a neuroprotective agent against ganglion cell degeneration. METHODS: Single-unit extracellular recording, electroretinogram (ERG), intracellular and whole-cell patch-clamp recording techniques were made from flatmounted, isolated retina, superfused eyecup, and living retinal slice preparations of the larval tiger salamander. RESULTS: Bath application of 20 microM betaxolol reduced the glutamate-induced increase of spontaneous spike rate in retinal ganglion cell by approximately 30%. The glutamate-induced postsynaptic current recorded under voltage-clamp conditions was reduced by 50 microM betaxolol, and the difference current-voltage (I-V) relation (I(Control)-I(betaxolol)) was N-shaped and AP5-sensitive, characteristic of N-methyl-D-aspartate receptor-mediated current. Application of 50 microM betaxolol reversibly reduced the voltage-gated sodium and calcium currents by approximately one third of their peak amplitudes. The times-to-action of betaxolol on ganglion cells are long (15-35 minutes for 20-50 microM betaxolol), indicative of modulation through slow biochemical cascades. Betaxolol, up to 100 microM, exerted no effects on horizontal cells or the ERG, suggesting that the primary actions of this beta1 blocker are restricted to retinal ganglion cells. CONCLUSIONS: These physiological experiments provide supporting evidence that betaxolol acts in a manner consistent with preventing retinal ganglion cell death induced by elevated extracellular glutamate or by increased spontaneous spike rates under pathologic conditions. The physiological actions of betaxolol lead to reducing neurotoxic effects in ganglion cells, which are the most susceptible retinal neurons to glutamate-induced damages under ischemic and glaucomatous conditions. Therefore, betaxolol has the potential to be a neuroprotective agent against retinal degeneration in patients with disorders mediated by such mechanisms.  (+info)

Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists. (4/69)

Betaxolol, a beta(1)-adrenoceptor antagonist used for the treatment of glaucoma, is known to be neuroprotective in paradigms of ischaemia/excitotoxicity. In this study, we examined whether betaxolol and other beta-adrenoceptor antagonists interact directly with neurotoxin binding to sites 1 and 2 of the voltage-sensitive sodium channel (Na(+) channel) in rat cerebrocortical synaptosomes. Betaxolol inhibited specific [(3)H]-batrachotoxinin-A 20-alpha-benzoate ([(3)H]-BTX-B) binding to neurotoxin site 2 in a concentration-dependent manner with an IC(50) value of 9.8 microM. Comparison of all the beta-adrenoceptor antagonists tested revealed a potency order of propranolol>betaxolol approximately levobetaxolol>levobunolol approximately carteolol>/=timolol>atenolol. None of the drugs caused a significant inhibition of [(3)H]-saxitoxin binding to neurotoxin receptor site 1, even at concentrations as high as 250 microM. Saturation experiments showed that betaxolol increased the K(D) of [(3)H]-BTX-B binding but had no effect on the B(max). The association kinetics of [(3)H]-BTX-B were unaffected by betaxolol, but the drug significantly accelerated the dissociation rate of the radioligand. These findings argue for a competitive, indirect, allosteric mode of inhibition of [(3)H]-BTX-B binding by betaxolol. Betaxolol inhibited veratridine-stimulated Na(+) influx in rat cortical synaptosomes with an IC(50) value of 28. 3 microM. Carteolol, levobunolol, timolol and atenolol were significantly less effective than betaxolol at reducing veratridine-evoked Na(+) influx. The ability of betaxolol to interact with neurotoxin site 2 of the Na(+) channel and inhibit Na(+) influx may have a role in its neuroprotective action in paradigms of excitotoxicity/ischaemia and in its therapeutic effect in glaucoma.  (+info)

Effects of glaucoma medications on the cardiorespiratory and intraocular pressure status of newly diagnosed glaucoma patients. (5/69)

AIMS: To evaluate the short term cardiovascular, respiratory, and intraocular pressure (IOP) effects of four glaucoma medications in newly diagnosed glaucoma patients. METHODS: 141 newly diagnosed glaucoma patients were recruited and underwent a full ocular, cardiovascular, and respiratory examination, including an electrocardiogram (ECG) and spirometry. They were prescribed one of four topical glaucoma medications and reviewed 3 months later. One eye of each patient was randomly chosen for analysis, performed using analysis of variance and the chi(2) test. RESULTS: Latanoprost had the greatest mean IOP lowering effect in both the primary open angle glaucoma (POAG) (p = 0.005) and the "presumed" normal tension glaucoma (NTG) groups (p = 0.33), reducing the IOP by 8.9 mm Hg and 4.1 mm Hg respectively. Timolol was associated with lowered pulse rates and reductions in the spirometry measurements. 41% of patients using brimonidine complained of systemic side effects and over 55% of patients using betaxolol complained of ocular irritation. 28% of patients required an alteration in their glaucoma management. CONCLUSIONS: Latanoprost appears to be a useful primary treatment for glaucoma patients, in view of superior IOP control and a low incidence of local and systemic side effects. Timolol causes a reduction in measurements of respiratory function, a concern in view of the potential subclinical reversible airways disease in the elderly glaucoma population. Brimonidine is associated with substantial, unpredictable systemic side effects and betaxolol causes ocular irritation and weak IOP control. Spirometry is advised in all patients receiving topical beta blocker therapy to control their glaucoma.  (+info)

Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors. (6/69)

Stable clones of HEK293 cells expressing either FLAG(TM) epitope-tagged, wild type human beta(1)- and beta(2)-adrenoceptors or C-terminally green fluorescent protein (GFP)-tagged forms of these receptors were established. The binding affinity of [(3)H]-dihydroalprenolol and other ligands was little affected by addition of GFP to the C-terminal of either receptor. Isoprenaline induced the internalisation of both beta(1)-adrenoceptor-GFP and beta(2)-adrenoceptor-GFP and following removal of the agonist both constructs were able to recycle to the cell surface. The extent of internalisation of beta(2)-adrenoceptor-GFP produced by isoprenaline was substantially greater than for beta(1)-adrenoceptor-GFP. C-terminal addition of GFP slowed markedly the rate of internalization of both the beta(1)-adrenoceptor and the beta(2)-adrenoceptor in response to isoprenaline. Sustained exposure to isoprenaline (24 h) produced substantially greater levels of downregulation of native beta(2)-adrenoceptor compared to beta(2)-adrenoceptor-GFP although both were equally effectively removed from the plasma membrane. Sustained exposure to isoprenaline resulted in a large fraction of beta(2)-adrenoceptor-GFP becoming trapped in internal vesicles/lysosomes but not degraded. Even after sustained exposure to isoprenaline a significant fraction of beta(1)-adrenoceptor-GFP remained at the cell surface. These results indicate that although GFP tagging of beta-adrenoceptors can provide qualitative visual patterns of agonist-induced receptor trafficking and regulation in HEK293 cells the quantitative details vary markedly from those obtained with the unmodified receptors.  (+info)

Topical ophthalmic beta blockers may cause release of histamine through cytotoxic effects on inflammatory cells. (7/69)

AIM: To evaluate the effects of beta blockers used in ophthalmology on the release of histamine from mixed cell preparations containing human leucocytes and basophils. METHODS: A mixed leucocyte and basophil preparation was obtained from venous blood of healthy non-atopic volunteers. Cell preparations were then incubated with betaxolol, metipranolol, timolol, or carteolol. After incubation for 1 hour the histamine content of the supernatant was analysed by automated fluorometric analysis. Cell viability was tested by measuring lactate dehydrogenase (LDH) concentrations. RESULTS: Betaxolol and metipranolol in concentrations between 10(-2) M and 10(-3) M liberated histamine from human blood cells in a dose dependent manner. Carteolol and timolol had no effect on histamine at these concentrations. At the same concentrations LDH was also detected in the supernatants of cell suspensions incubated with metipranolol or betaxolol. CONCLUSIONS: Betaxolol and metipranolol induce substantial histamine release from human leucocytes, probably as a result of their cytotoxic effect.  (+info)

Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase-tagged, constitutively active mutant, G-protein-coupled receptor. (8/69)

The wild-type beta2-adrenoceptor and a constitutively active mutant of this receptor were C-terminally tagged with luciferase from the sea pansy Renilla reniformis. C-terminal addition of Renilla luciferase did not substantially alter the levels of expression of either form of the receptor, the elevated constitutive activity of the mutant beta2-adrenoceptor nor the capacity of isoprenaline to elevate cyclic AMP levels in intact cells expressing these constructs. Treatment of cells expressing constitutively active mutant beta2-adrenoceptor-Renilla luciferase with antagonist/inverse agonist ligands resulted in upregulation of levels of this polypeptide which could be monitored by the elevated luciferase activity. The pEC50 for ligand-induced luciferase upregulation and ligand affinity to bind the receptor were highly correlated. Similar upregulation could be observed following sustained treatment with agonist ligands. These effects were only observed at a constitutively active mutant of the beta2-adrenoceptor. Co-expression of the wild-type beta2-adrenoceptor C-terminally tagged with the luciferase from Photinus pyralis did not result in ligand-induced upregulation of the levels of activity of this luciferase. Co-expression of the constitutively active mutant beta2-adrenoceptor-Renilla luciferase and an equivalent mutant of the alpha1b-adrenoceptor C-terminally tagged with green fluorescent protein allowed pharmacological selectivity of adrenoceptor antagonists to be demonstrated. This approach offers a sensitive and convenient means, which is amenable to high throughput analysis, to monitor ligand binding to a constitutively active mutant receptor. As no prior knowledge of receptor ligands is required this approach may be suitable to identify ligands at orphan G protein-coupled receptors.  (+info)

TY - JOUR. T1 - Effects of timolol and betaxolol on choroidal blood flow in the rabbit. AU - Kiel, J. W.. AU - Patel, P.. PY - 1998/11. Y1 - 1998/11. N2 - This study evaluated the effects of the topical β-adrenergic antagonist betaxolol and the non-selective β-adrenergic antagonist timolol on the choroidal pressure-flow relationship. Pentobarbital-anesthetized rabbits were instrumented with hydraulic occluders on the aorta and inferior vena cava to control MAP an ear artery cannula to measure mean arterial pressure (MAP), and two vitreous cannulas to control and measure intraocular pressure (IOP). Choroidal blood flow was measured by laser Doppler flowmetry with the fiber- optic probe tip positioned over the posterior pole. Choroidal pressure-flow curves were obtained before and 30 min after topical application of 0.1 ml of betaxolol (Betoptic, 0.5%, n = 10), timolol (Timoptic, 0.5%, n = 10) or saline (n = 8) by varying the MAP without controlling the IOP and by raising IOP while holding the ...
Betaxolol (trade names Betoptic, Betoptic S, Lokren, Kerlone) is a selective beta1 receptor blocker used in the treatment of hypertension and glaucoma. Being selective for beta1 receptors, it typically has fewer systemic side effects than non-selective beta-blockers, for example, not causing bronchospasm (mediated by beta2 receptors) as timolol may. Betaxolol also shows greater affininty for beta1 receptors than metoprolol. In addition to its effect on the heart, betaxolol reduces the pressure within the eye (intraocular pressure). This effect is thought to be caused by reducing the production of the liquid (which is called the aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma. Betaxolol was approved by the U.S. Food and Drug Administration (FDA) for ocular use as a 0.5% solution (Betoptic) in 1985 ...
Betaxolol Tablets (Betaxolol) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
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Betaxolol ophthalmic is sometimes given together with other eye medications. Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using betaxolol ophthalmic. Do not use the medications at the same time.. Betaxolol ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly. Do not use this medication while you are wearing contact lenses. Betaxolol ophthalmic may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using betaxolol before putting your contact lenses in. ...
Betaxolol ophthalmic is sometimes given together with other eye medications. Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using betaxolol ophthalmic. Do not use the medications at the same time.. Betaxolol ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly. Do not use this medication while you are wearing contact lenses. Betaxolol ophthalmic may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using betaxolol before putting your contact lenses in. ...
TY - JOUR. T1 - Adverse 30-day outcomes after cardiac surgery. T2 - predictive role of intraoperative myocardial acidosis. AU - Kumbhani, Dharam J.. AU - Healey, Nancy A.. AU - Biswas, Kunda S.. AU - Birjiniuk, Vladimir. AU - Crittenden, Michael D.. AU - Treanor, Patrick R.. AU - Khuri, Shukri F.. PY - 2005/11. Y1 - 2005/11. N2 - Background. Regional myocardial acidosis in patients undergoing cardiac surgery has been shown to be reflective of regional myocardial ischemia. This study elucidates the relationship between intraoperative regional myocardial acidosis and 30-day postoperative outcomes after cardiac surgery. Methods. Intramyocardial tissue pH in the anterior and posterior left ventricular walls was measured in 397 adult patients undergoing valve replacement or coronary revascularization surgery between 1987 and 2001. Dedicated nurses and research assistants prospectively collected preoperative, intraoperative, and outcomes data. Regional myocardial acidosis was defined in terms of pH ...
Falcon Pharmaceuticals, Ltd.: Betaxolol Hydrochloride Ophthalmic Solution has been shown to be effective in lowering intraocular pressure and is indicated in...
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What Betoptic S is used forBetoptic S Eye Drops contain the active ingredient betaxolol hydrochloride. Betaxolol hydrochloride belongs to a class of medicines known as beta-adrenergic blocking agents . Your doctor has prescribed Betoptic S Eye Drops for you because the pressure within your eye(s), known as intraocular pressure , is higher than normal. This raised pressure may damage your eyesight and lead to a condition known as glaucoma. Betoptic S Eye Drops are used, either alone or in combination..
· Chronic open-angle glaucoma · Intraocular Hypertonia. · The recommended dosage is one drop of BETOPTIC 0.25%, ophthalmic suspension in the affected eye, twice a day (morning and evening). · In some patients, normalization of pressure, intraocular pressure by BETOPTIC 0.25 PERCENT, suspension, ophthalmic sometimes requires a few weeks, so evaluation of the treatment should include a determination of the intra-ocular pressure -ocular after one treatment period with BETOPTIC
Sigma-Aldrich offers abstracts and full-text articles by [Luminita Iliuta, Ruxandra Christodorescu, Daniela Filpescu, Horatiu Moldovan, Bogdan Radulescu, Rasvan Vasile].
Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .. Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .. Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous .. ...
This medicine is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Shake well before use. Tilt your head back slightly and pull your lower eyelid down with your index finger to form a pouch. Try not to touch the tip of the dropper to your eye, fingertips, or any other surface. Squeeze the prescribed number of drops into the pouch. Close the eye for a few moments to spread the drops and apply gentle finger pressure to the inner corner of the eye for 1 to 2 minutes. Use your doses at regular intervals. Do not use your medicine more often than directed. Do not stop using except on the advice of your doctor or health care professional.. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.. ...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Not exactly: The ability to react to certain proteins in an allergic way is passed on from parents to their children, but a specific allergy is not. So if a mom is allergic to pollen and the dad is allergic to fire ants, their child may develop allergies but it may be to a food instead. If 1 parent has allergies, the child is 50% likely to develop allergies, but its a 75% chance if both parents are allergic. ...Read more ...
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Longer-term stud- ies have shown that this drug has similar tolerability to betaxolol, timolol, and pilocarpine. Improving lopinavir genotype algorithm through phenotype correlations novel muta- tion quue and amprenavir cross-resistance. The key players who are obligated under GCP regulations are described below and will be referenced throughout this article Investigator. J Antimicrob Chemother 2002;50 1059в1063 73.
A comparison of the efficacy of betaxolol and timolol in ocular hypertension with or without adrenaline (pages 173-177). J. B. Clark, A. M. V. Brooks, C. A. Harper, N. Mantzioros and W. E. Gillies. Version of Record online: 7 NOV 2007 , DOI: 10.1111/j.1442-9071.1989.tb00509.x. ...
Betoptic eye drops contain the active ingredient betaxolol hydrochloride. Buy Betoptic S Eye Drops 0.25 online at lowest discount price. BETOPTIC Eye Drops do this by reducing the amount of fluid produced within your eye s. Home Drugs A to Z Betoptic S Consumer Information. Select from the options below to find the exact version of betoptic s that you want.. ...
Detailed dosage guidelines and administration information for Kerlone (betaxolol hydrochloride). Includes dose adjustments, warnings and precautions.
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In this lesson, youll learn a bit about the adrenergic system and how it relates to the names and functions of various cardioselective and...
Title:Betaxolol Hydrochloride Loaded Chitosan Nanoparticles for Ocular Delivery and their Anti-glaucoma Efficacy. VOLUME: 10 ISSUE: 5. Author(s):Kunal Jain, R. Suresh Kumar, Sumeet Sood and G. Dhyanandhan. Affiliation:Department of Pharmaceutics, J.S.S College of Pharmacy, Udhagamandalam, India.. Keywords:Betaxolol, glaucoma, chitosan, nanoparticles, ocular delivery.. Abstract:Many effective anti-glaucoma drugs available for the treatment of ocular hypertension and open angle glaucoma are associated with rapid and extensive precorneal loss caused by the drainage and high tear fluid turnover. The present study involved design of mucoadhesive nanoparticulate carrier system containing betaxolol hydrochloride for ocular delivery to improve its corneal permeability and precorneal residence time. Nanoparticles were prepared by spontaneous emulsification method and had a particle size of 168-260nm with zeta potential of 25.2-26.4 mV. The in vitro release studies in simulated tear fluid exhibited ...
beta 1- and beta 2-Adrenergic receptors co-exist in the adult rat ventricle. We have employed radioligand binding and cell purification techniques to determine the cellular origin of these receptors. The beta-adrenergic antagonist ligand (+/-)-[125I] iodocyanopindolol binds to 2 X 10(5) receptors per purified adult rat cardiomyocyte, with a dissociation constant of 70 pM. The subtype-selective antagonists betaxolol (beta 1), practolol (beta 1), and zinterol (beta 2) compete for [125I]iodocyanopindolol-binding sites on intact myocytes in monophasic manners with dissociation constants of 46, 845, and 923 nM, respectively. [125I]iodocyanopindolol binding to membranes prepared from nonmyocyte elements of rat ventricle occurs with a dissociation constant of 43 pM and a capacity of 88 fmol/mg membrane protein. Computer analysis of competition of [125I]iodocyanopindolol binding by betaxolol, practolol, and zinterol in nonmyocyte membranes demonstrates biphasic curves that comprise binding to both beta ...
This study shows that histamine is liberated from human basophils by betaxolol and metipranolol and, to a significantly lesser extent, by timolol. The fact that we detected LDH in the supernatant indicated that the β blocker concentrations we used were cytotoxic to leucocytes. This cytotoxic effect may also explain the histamine liberation because we do not consider that high concentrations of β blockers are less toxic to basophils than to other leucocytes. Also, in previous studies other authors have used LDH levels to determine the cytotoxic effects on basophils in similar test conditions.14 Betaxolol and timolol formulations are commercially available in 0.1%, 0.25%, and 0.5% concentrations and metipranolol formulations are commercially available in 0.1%, 0.3%, and 0.6% which equals approximately 2.5 × 10-3 to 2 × 10-2 M. The cytotoxicity found in these experiments therefore occurs at concentrations that are used in commercial formulations. However, it should be noted that, upon ...
TY - JOUR. T1 - Patients with diabetes mellitus undergoing cardiac surgery are at greater risk for developing intraoperative myocardial acidosis. AU - Kumbhani, Dharam J.. AU - Healey, Nancy A.. AU - Thatte, Hemant S.. AU - Nawas, Sammy. AU - Crittenden, Michael D.. AU - Birjiniuk, Vladimir. AU - Treanor, Patrick R.. AU - Khuri, Shukri F.. PY - 2007/6. Y1 - 2007/6. N2 - Objective: In patients undergoing cardiac surgery, intraoperative myocardial acidosis, which quantifies regional myocardial ischemia, has been shown to increase the risk of adverse postoperative outcomes. In this study, we sought to determine the course of intraoperative myocardial acidosis and its impact on postoperative survival in patients with diabetes mellitus undergoing cardiac surgery. Methods: Intraoperative myocardial tissue pH37C was continuously measured in the anterior and posterior left ventricular walls in 264 patients undergoing cardiac surgery; 74 (28.0%) of the patients had diabetes (insulin-dependent diabetes: ...
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Tell your doctor about all other medications you use, especially: blood thinners (warfarin), lithium, methotrexate, diuretics (furosemide), steroids (prednisone, hydrocortisone, prednisolone) aspirin, non-steroidal anti-inflammatory drugs (etodolac, flurbiprofen, indomethacin, ketoprofen, meloxicam, naproxen), ACE inhibitors (benazepril, captopril, fosinopril, enalapril, lisinopril, ramipril), angiotensin II receptor blockers (eposartan, losartan, valsartan, telmisartan), beta blockers (betaxolol, propranolol, metoprolol), digoxin, thrombolytics (streptokinase, alteplase, reteplase), SSRI or SNRI medications (duloxetine, citalopram, fluvoxamine, milnacipran). Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking ...
Tell your doctor about all other medications you use, especially: blood thinners (warfarin), lithium, methotrexate, diuretics (furosemide), steroids (prednisone, hydrocortisone, prednisolone) aspirin, non-steroidal anti-inflammatory drugs (etodolac, flurbiprofen, indomethacin, ketoprofen, meloxicam, naproxen), ACE inhibitors (benazepril, captopril, fosinopril, enalapril, lisinopril, ramipril), angiotensin II receptor blockers (eposartan, losartan, valsartan, telmisartan), beta blockers (betaxolol, propranolol, metoprolol), digoxin, thrombolytics (streptokinase, alteplase, reteplase), SSRI or SNRI medications (duloxetine, citalopram, fluvoxamine, milnacipran). Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking ...
Tell your doctor about all other medications you use, especially: blood thinners (warfarin), lithium, methotrexate, diuretics (furosemide), steroids (prednisone, hydrocortisone, prednisolone) aspirin, non-steroidal anti-inflammatory drugs (etodolac, flurbiprofen, indomethacin, ketoprofen, meloxicam, naproxen), ACE inhibitors (benazepril, captopril, fosinopril, enalapril, lisinopril, ramipril), angiotensin II receptor blockers (eposartan, losartan, valsartan, telmisartan), beta blockers (betaxolol, propranolol, metoprolol), digoxin, thrombolytics (streptokinase, alteplase, reteplase), SSRI or SNRI medications (duloxetine, citalopram, fluvoxamine, milnacipran). Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking ...
Medication refill hands cannot be. Atenolol (Tenormin). Betaxolol (Kerlone). Bisoprolol Fumarate (Zebeta,Ziac). Blocadren. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names. The name diclofenac derives from its chemical name: 2-(2. Pain (IV Administration). Indicated for management of mild-to-moderate pain and moderate-to-severe pain alone or in combination with opioid analgesics. Use for the shortest duration consistent with individual patient treatment goals. mg IV bolus injection infused over 15 seconds q6hr as needed, not to exceed ...
Side effects inherent to systemic beta-blockers make propranolol contraindicated in patients with certain cardiac and pulmonary conditions. Due to systemic absorption, topical beta-blockers such as timolol maleate, which are used as anti-glaucoma agents, have similar contraindications. The follow report describes an ocular hypertensive patient who was switched from timolol maleate to latanoprost because of a newly diagnosed possibility of mild COPD. The patient developed a bilateral hand tremor, which was previously blocked by systemic absorption of the topical beta-blocker. Included are classification, differential diagnosis and treatment of essential tremor, as well as a review of the mechanism of action and contraindications of timolol maleate and latanoprost.
Get information, facts, and pictures about Adrenergic beta-antagonists at Encyclopedia.com. Make research projects and school reports about Adrenergic beta-antagonists easy with credible articles from our FREE, online encyclopedia and dictionary.
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The CSM has advised that beta-blockers, including those considered to be cardioselective, should not be given to patients with a history of asthma or bronchospasm. However, in rare situations where there is no alternative a cardioselective beta-blocker may be used with extreme caution under specialist supervision. Combination preparations containing a beta-blocker are not recommended as they lack flexibility and may not be available in dose combinations appropriate for individual patients ...
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Betaxolol Cocco, G; Alfiero, R; Pouleur, H (1992). "An evaluation of the safety of the beta-modulator cicloprolol in chronic ...
Timolol, Levobunolol, and Betaxolol are common beta blockers prescribed to treat glaucoma. Alpha-adrenergic agonists work by ...
... include: Acebutolol Atenolol Betaxolol Bisoprolol Metoprolol Nadolol Penbutolol Phenylpropanolamine Pindolol ...
Atenolol Betaxolol Bisoprolol Celiprolol Esmolol Metoprolol Nebivolol β2-selective agents Butaxamine (weak α-adrenergic agonist ...
Cloranolol QC07AA90 Carazolol C07AB01 Practolol C07AB02 Metoprolol C07AB03 Atenolol C07AB04 Acebutolol C07AB05 Betaxolol ...
Betaxolol (in hypertension and glaucoma) Bisoprolol (in hypertension, coronary heart disease, arrhythmias, myocardial ...
The molecular formula C18H29NO3 (molar mass: 307.43 g/mol, exact mass: 307.2147 u) may refer to: Betaxolol Butamirate ...
Beta blockers acebutolol atenolol bisoprolol betaxolol carteolol carvedilol labetalol metoprolol nadolol nebivolol oxprenolol ...
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... is a selective β2 adrenergic receptor (adrenoreceptor) antagonist or beta blocker[1][2] . ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor.[3][4] The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008. ICI-118,551 has no known therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, as few other specific antagonists for this receptor are known.[5] ICI-118,551 has been used in pre-clinical studies using murine models.[6][7][8] When dissolved in saline, the compound crosses the blood-brain barrier. Common systemic doses used in rodent research are 0.5 or 1 mg/kg although efficacy has been demonstrated at doses as low as 0.0001 mg/kg in rhesus monkeys.[9] Doses up to 20 mg/kg have been used without toxicity. At room temperature in saline, the ICI 118,551 hydrochloride is soluble to ...
There are a variety of clinically useful ergoline derivatives for the purpose of vasoconstriction, the treatment of migraines, and treatment of Parkinson's disease. Ergoline alkaloids found their place in pharmacology long before modern medicine as preparations of ergot were often used by midwives in the 12th century to stimulate childbirth.[10] Following Arthur Stoll's isolation of ergometrine, the therapeutic use of ergoline derivatives became well explored. The induction of uterine contractions via the preparation of ergot was attributed to ergonovine, an ergoline derivative found in ergot, which is a powerful oxytocic. From this, methergine, a synthetic derivative, was elucidated.[7] While used to facilitate child birth, ergoline derivatives can pass into breast milk and should not be used during breastfeeding.[11] They are uterine contractors that can increase the risk of miscarriage during pregnancy.[3] Another example of medically relevant ergoline alkaloids is ergotamine, an alkaloid ...
The most common side effect is eye irritation felt as stinging or burning, which occurs in up to a third of patients. Blepharoconjunctivitis occurs in up to 5% of patients. Rarer adverse effects include keratitis, edema and increased lacrimation.[2][3] Allergies are rare, but seem to be more common than under the related drug timolol.[1] If the substance reaches the nasal mucosa via the tear duct, it can be absorbed into the bloodstream and cause systemic side effects. These include orthostatic hypotension (low blood pressure) and other effects on the heart and circulatory system, breathing problems in people with asthma, and skin symptoms such as itching and aggravation of psoriasis.[1] ...
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... was discovered by scientists at Angelini, who also discovered trazodone.[15] Its development names have included ST-1191 and McN-A-2673-11.[16][1] The INN etoperidone was proposed in 1976 and recommended in 1977.[17][18] The drug was given brand names in Spain (Centren (Esteve) and Depraser (Lepori)) and Italy (Staff (Sigma Tau))[1] and was also given the brand names Axiomin and Etonin,[16] but it is not entirely clear if it was actually marketed; the Pharmaceutical Manufacturing Encyclopedia provides no dates for commercial introduction.[19] According to Micromedex's Index Nominum: International Drug Directory, etoperidone was indeed previously marketed in Spain and Italy.[1] ...
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... (INN) is a drug which is used in scientific research. It acts as both a selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor.[1][2] Idazoxan has been under investigation as an antidepressant, but it did not reach the market as such. More recently, it is under investigation as an adjunctive treatment in schizophrenia. Due to its alpha-2 receptor antagonism it is capable of enhancing therapeutic effects of antipsychotics, possibly by enhancing dopamine neurotransmission in the prefrontal cortex of the brain, a brain area thought to be involved in the pathogenesis of schizophrenia. ...
Since silodosin has high affinity for the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers). On the other side, the high selectivity seems to be the cause of silodosin's typical side effect of loss of seminal emission.[3] As α1A adrenoceptor antagonists are being investigated as a means to male birth control due to their ability to inhibit ejaculation but not orgasm, a trial with 15 male volunteers was conducted. While silodosin was completely efficacious in preventing the release of semen in all subjects, 12 out of the 15 patients reported mild discomfort upon orgasm. The men also reported the psychosexual side effect of being strongly dissatisfied by their lack of ejaculation.[4] ...
Most frequent side effects are nausea, orthostatic hypotension, headaches, and vomiting through stimulation of the brainstem vomiting centre.[9] Vasospasms with serious consequences such as myocardial infarction and stroke that have been reported in connection with the puerperium, appear to be extremely rare events.[10] Peripheral vasospasm (of the fingers or toes) can cause Raynaud's Phenomenon. Bromocriptine use has been anecdotally associated with causing or worsening psychotic symptoms (its mechanism is in opposition of most antipsychotics, whose mechanisms generally block dopamine).[11] Pulmonary fibrosis has been reported when bromocriptine was used in high doses for the treatment of Parkinson's disease.[12] Use to suppress milk production after childbirth was reviewed in 2014 and it was concluded that in this context a causal association with serious cardiovascular, neurological or psychiatric events could not be excluded with an overall incidence rate estimated to range between 0.005% ...
... (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The drug's name is derived from the methylsulfoxy and piperidine functional groups in its chemical structure. It has central antiadrenergic, antidopaminergic, antiserotonergic and weak muscarinic anticholinergic effects. Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram.[1] It currently appears to be unavailable worldwide. ...
... (MDPPP) is a stimulant designer drug. It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills.[1] It shares a similar chemical structure with α-PPP and MDPV,[2][3][4] and has been shown to have reinforcing effects in rats.[5] ...
... is a choline carbamate and a positively charged quaternary ammonium compound.[2] It is not well absorbed in the gastro-intestinal tract and does not cross the blood-brain barrier. It is usually administered topical ocular or through intraocular injection.[2] Carbachol is not easily metabolized by cholinesterase, it has a 2 to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. Since carbachol is poorly absorbed through topical administration, benzalkonium chloride is mixed in to promote absorption.[2]. Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors.[2] In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow.[2]. In the cat and rat, carbachol is well known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM ...
Brand names include Eskazinyl, Eskazine, Jatroneural, Modalina, Stelazine, Terfluzine, Trifluoperaz, Triftazin. In the United Kingdom and some other countries, trifluoperazine is sold and marketed under the brand 'Stelazine'. The drug is sold as tablet, liquid and 'Trifluoperazine-injectable USP' for deep intramuscular short-term use. GP studying pharmacological data has indicated cases of neck vertebrae irreversible fusing leading to NHS preparations being predominantly of the liquid form trifluoperazine as opposed to the tablet form as in Stela zine etc. In the past, trifluoperazine was used in fixed combinations with the MAO inhibitor (antidepressant) tranylcypromine (tranylcypromine/trifluoperazine) to attenuate the strong stimulating effects of this antidepressant. This combination was sold under the brand name Jatrosom N. Likewise a combination with amobarbital (potent sedative/hypnotic agent) for the amelioration of psychoneurosis and insomnia existed under the brand name Jalonac. In ...
... (marketed as Hytrin or Zayasel) is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement. It is available in 1 mg, 2 mg, 5 mg or 10 mg doses.[1] It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls. Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon.[2] Sexual side effects are rare, but may include priapism or erectile dysfunction. ...
... eye drops may cause blurred vision, eye irritation and dilated pupils.[6] Tetryzoline is not suitable for prolonged use as its vasoconstrictive effects within the eye eventually decrease or stop. When body is accustomed to tetryzoline, ceasing its use may cause redness of the eyes.[7] Intranasal use of tetryzoline may cause transient burning, stinging, or dryness of the mucosa and sneezing. Prolonged intranasal use often causes opposite effects in the form of rebound congestion with effects such as chronic redness, swelling and rhinitis. Prolonged use thus may result in overuse of the drug.[6] Overdose most often causes slow heart rate. Respiratory depression, low blood pressure, constricted pupils, hypothermia, brief episodes of high blood pressure,[8] drowsiness, headaches and vomiting may also occur.[9] In serious cases some of these effects may result in circulatory shock.[6] Most often overdoses occur in children who have ingested the drug.[8] There is no antidote for ...
... , as a lipophilic ester, easily penetrates the cornea and is then activated to the carboxylic acid, tafluprost acid. Onset of action is 2 to 4 hours after application, the maximal effect is reached after 12 hours, and ocular pressure remains lowered for at least 24 hours.[2][3] Tafluprost acid is inactivated by beta oxidation to 1,2-dinortafluprost acid, 1,2,3,4-tetranortafluprost acid, and its lactone, which are subsequently glucuronidated or hydroxylated. The cytochrome P450 liver enzymes play no role in the metabolism.[3] An analogous pathway (at least up to the tetranor-metabolites) has been found for latanoprost and travoprost. ...
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The drug works by stimulating adrenergic receptors on the lamina propria of blood vessels in the nose. The decongestant effect is due to constriction of large veins in the nose which swell up during the inflammation of any infection or allergy of the nose. The smaller arteries are also constricted and this causes the colour of the nasal epithelium to be visibly paler after dosage. Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to α1 and α2 adrenergic receptors[8] in the nasal mucosa. Due to its sympathomimetic effects, it should not be used by people with high blood pressure, or other heart problems. Extended usage of xylometazoline can result in decreased effectiveness or a buildup of tolerance against the drug.[9] The number of receptors decreases, and when the administration of the drug is ceased, chronic congestion can occur; this is called rhinitis medicamentosa, commonly referred to as rebound congestion. Moreover, ...
Ipratropium/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[2][3] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[2] It is taken by inhalation.[4] Common side effects include sore throat, muscle cramps, and nausea.[2] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[2] Safety in pregnancy is unclear.[1] Each medication typically decreases bronchospasm and does so via different mechanisms.[2] The combination was approved for medical use in the United States in 1996.[4] It is available as a generic medication.[3] Sixty doses in the United Kingdom costs the NHS about 18 £ as of 2019.[3] In the United States the wholesale cost of this amount is about US$9.50.[5] In 2016 it was the 166th most prescribed medication in the United States with more than 3 million prescriptions.[6] ...
... means "related to catecholamines". The catecholamine neurotransmitters include dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline). A catecholaminergic agent (or drug) is a chemical which functions to directly modulate the catecholamine systems in the body or brain. Examples include adrenergics and dopaminergics. ...
... works by activating α2A adrenoceptors in the central nervous system. This results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone, which lowers both systolic and diastolic blood pressure.[13] In ADHD, guanfacine works by strengthening regulation of attention and behavior by the prefrontal cortex.[14] These enhancing effects on prefrontal cortical functions are thought to be due to drug stimulation of post-synaptic α2A adrenoceptors on dendritic spines, which inhibit cAMP-mediated opening of HCN and KCNQ channels and thus strengthen prefrontal cortical synaptic connectivity and enhance neuronal firing.[14][15] The use of guanfacine for treating prefrontal disorders was developed by the Arnsten lab at Yale University based on understanding the needs of the prefrontal cortex.[14][16] ...
Information about this betaxolol-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown an ... Betaxolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or ... Betaxolol is used alone or together with other medicines (such as hydrochlorothiazide) to treat high blood pressure ( ... Appropriate studies have not been performed on the relationship of age to the effects of betaxolol in the pediatric population ...
Betaxolol has caused birth defects in animals; adequate human studies have not been done. Use of this drug should be avoided ... Betaxolol slows the rate and force of contraction of the heart by blocking certain nerve impulses, thus reducing blood pressure ... Lifelong therapy with betaxolol may be necessary. Do not stop taking the medication suddenly, as this may result in potentially ... Betaxolol should be used with caution in people with diabetes, especially insulin-dependent diabetes, since the drug may mask ...
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Betaxolol indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information from ... Betaxolol - Bausch and Lomb. Betaxolol - Biosano Laboratorios. Betaxolol - Chile Laboratorios. Betaxolol - KVK-TECH. Betaxolol ... Sab-Betaxolol - Sandoz; Sabex. Sandoz Betaxolol - Sandoz. Tonobexol - Novartis Betaxolol Hydrochloride. Benzalkonium Chloride ... Betaxolol Hydrochloride. Chlorthalidone Kerledex - Pfizer; Lorex; Sanofi-Aventis Betaxolol Hydrochloride. Pilocarpine ...
In this study, we tried to compare the efficacy and safety of betaxolol vs. metoprolol immediately postoperatively in coronary ... Prevention of perioperative atrial fibrillation with betablockers in coronary surgery: betaxolol versus metoprolol.. [Luminita ... Our trial was open-label, randomized, multicentric enrolling 1352 coronary surgery patients randomized to receive betaxolol or ... At the end of the study the incidence and probability of early postoperative AF with betaxolol was lower than with metoprolol ...
Betaxolol (Definition) Betaxolol is a high strength steroid which is a kind of topical steroid (skin-related medication). ... ... Betoptic (betaxolol): Betoptic (betaxolol) is FDA pregnancy category C. This means it has not been studied adequately in human ... Betoptic (betaxolol): Betoptic (betaxolol) can be beneficial in treatment of ocular hypertension and chronic open-angle ... Betoptic (betaxolol): "Hypersensitivity to any component of this product. BETOPTIC (betaxolol) Ophthalmic Solution is ...
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BETAXOLOL HYDROCHLORIDE. betaxolol hydrochloride. TABLET;ORAL. 075541-002. Oct 22, 1999. AB. RX. No. Yes. ➠ Subscribe. ➠ ... BETAXOLOL HYDROCHLORIDE. betaxolol hydrochloride. TABLET;ORAL. 078962-001. Jun 27, 2008. AB. RX. No. No. ➠ Subscribe. ➠ ... Betaxolol hydrochloride - Generic Drug Details. « Back to Dashboard. What are the generic sources for betaxolol hydrochloride ... BETAXOLOL HYDROCHLORIDE. betaxolol hydrochloride. SOLUTION/DROPS;OPHTHALMIC. 075630-001. Apr 12, 2001. AT. RX. No. No. ➠ ...
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Kiel JW, Patel P. Effects of timolol and betaxolol on choroidal blood flow in the rabbit. Experimental Eye Research. 1998 Nov; ... Kiel, J. W. ; Patel, P. / Effects of timolol and betaxolol on choroidal blood flow in the rabbit. In: Experimental Eye Research ... Kiel, JW & Patel, P 1998, Effects of timolol and betaxolol on choroidal blood flow in the rabbit, Experimental Eye Research, ... Kiel, J. W., & Patel, P. (1998). Effects of timolol and betaxolol on choroidal blood flow in the rabbit. Experimental Eye ...
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Betaxolol Ophthalmic: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Betaxolol eye drops control glaucoma but do not cure it. Continue to use betaxolol eye drops even if you feel well. Do not stop ... Before using betaxolol eye drops,. *tell your doctor and pharmacist if you are allergic to betaxolol or any other drugs. ... Ophthalmic betaxolol comes as a solution (liquid) and a suspension (liquid) to instill in the eyes. Ophthalmic betaxolol is ...
Betaxolol eye drops are also available without a brand name, ie as the generic medicine.) Betaxolol is used to reduce the ... Betoptic eye drops contain the active ingredient betaxolol hydrochloride, which is a type of medicine called a beta-blocker. ( ... Betaxolol eye drops are also available without a brand name, ie as the generic medicine.) Betaxolol is used to reduce the ... Betaxolol eye drops are also available without a brand name, ie as the generic medicine.) Betaxolol is used to reduce the ...
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The purpose of this study is to evaluate the safety and efficacy of BETOPTIC S and Timolol Gel-forming solution in pediatric patients. Patients will dose with study drug at 8 am and 8 pm daily for twelve weeks. Patients will have vision tested, slit lamp exam, blood pressure and pulse checks at each visit. Patients will have a dilated fundus exam and corneal measurements taken at first and last visit.. Register für klinische Studien. ICH GCP.
  • Kerledex (betaxolol hydrochloride and chlorthalidone) is a combination product indicated for the treatment of hypertension. (rxlist.com)
  • It combines the activities of betaxolol hydrochloride, a β 1 -selective (cardioselective) adrenergic receptor blocking agent, with chlorthalidone, a monosulfamyl diuretic. (rxlist.com)
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  • There are eleven drug master file entries for betaxolol hydrochloride. (drugpatentwatch.com)
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  • Betaxolol Hydrochloride Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. (medlibrary.org)
  • Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular weight of 343.89. (medlibrary.org)
  • 5.6 mg betaxolol hydrochloride equivalent to betaxolol base 5 mg. (medlibrary.org)
  • Betaxolol Hydrochloride, a cardioselective (beta-1-adrenergic) receptor blocking agent, does not have significant membrane-stabilizing (local anesthetic) activity and is devoid of intrinsic sympathomimetic action. (medlibrary.org)
  • When instilled in the eye, Betaxolol Hydrochloride Ophthalmic Solution has the action of reducing elevated as well as normal intraocular pressure, whether or not accompanied by glaucoma. (medlibrary.org)
  • Betaxolol Hydrochloride Ophthalmic Solution has the action of reducing elevated as well as normal intraocular pressure, and the mechanism of ocular hypotensive action appears to be a reduction of aqueous production as demonstrated by tonography and aqueous fluorophotometry. (medlibrary.org)
  • The onset of action with Betaxolol Hydrochloride Ophthalmic Solution can generally be noted within 30 minutes and the maximal effect can usually be detected 2 hours after topical administration. (medlibrary.org)
  • Clinical observation of glaucoma patients treated with Betaxolol Hydrochloride Ophthalmic Solution for up to three years shows that the intraocular pressure lowering effect is well maintained. (medlibrary.org)
  • Clinical studies show that topical Betaxolol Hydrochloride Ophthalmic Solution reduces mean intraocular pressure 25% from baseline. (medlibrary.org)
  • In trials using 22 mmHg as a generally accepted index of intraocular pressure control, Betaxolol Hydrochloride Ophthalmic Solution was effective in more than 94% of the population studied, of which 73% were treated with the beta blocker alone. (medlibrary.org)
  • Can children use Betoptic (betaxolol)? (healthtap.com)
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  • BETOPTIC (betaxolol) Ophthalmic Solution is contraindicated in patients with sinus bradycardia, greater than a first degree atrioventricular block, cardiogenic shock , or patients with overt cardiac failure. (healthtap.com)
  • What is the generic form of Betoptic (betaxolol)? (healthtap.com)
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  • Betoptic (betaxolol) can be beneficial in treatment of ocular hypertension and chronic open-angle glaucoma. (healthtap.com)
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  • Yes, Betoptic (betaxolol) is a prescription medication. (healthtap.com)
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  • Betoptic (betaxolol) is FDA pregnancy category C. This means it has not been studied adequately in human pregnancies. (healthtap.com)
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  • Choroidal pressure-flow curves were obtained before and 30 min after topical application of 0.1 ml of betaxolol (Betoptic, 0.5%, n = 10), timolol (Timoptic, 0.5%, n = 10) or saline (n = 8) by varying the MAP without controlling the IOP and by raising IOP while holding the MAP constant at 70 mmHg. (uthscsa.edu)
  • Ophthalmic betaxolol (one drop in each eye) was compared to timolol and placebo in a three-way crossover study challenging nine patients with reactive airway disease who were selected on the basis of having at least a 15% reduction in the forced expiratory volume in one second (FEV 1 ) after administration of ophthalmic timolol. (medlibrary.org)
  • No evidence of cardiovascular beta-adrenergic blockade during exercise was observed with betaxolol in a double-masked, three-way crossover study in 24 normal subjects comparing ophthalmic betaxolol, timolol and placebo for effect on blood pressure and heart rate. (medlibrary.org)
  • This study evaluated the effects of the topical β-adrenergic antagonist betaxolol and the non-selective β-adrenergic antagonist timolol on the choroidal pressure-flow relationship. (uthscsa.edu)
  • The IOP was significantly reduced by betaxolol and timolol but not by Saline. (uthscsa.edu)
  • MAP was also slightly, but significantly, reduced after betaxolol but not after timolol or saline. (uthscsa.edu)
  • However, the systemic hypotensive response to isoproterenol (8 μg/kg, i.v.) was blunted after betaxolol and timolol indicating appreciable systemic absorption of both drugs. (uthscsa.edu)
  • Timolol, but not betaxolol or saline, caused a significant, small increase in baseline choroidal vascular resistance. (uthscsa.edu)
  • We conclude that both drugs reach the systemic circulation after topical application, but neither betaxolol nor timolol alter the choroidal response to acute changes in perfusion pressure. (uthscsa.edu)
  • Kiel, JW & Patel, P 1998, ' Effects of timolol and betaxolol on choroidal blood flow in the rabbit ', Experimental Eye Research , vol. 67, no. 5, pp. 501-507. (uthscsa.edu)
  • BETAXOLOL (be TAX oh lol) is used in the eye to treat open-angle glaucoma and high pressure in the eye. (yourcareeverywhere.com)
  • After ocular instillation, betaxolol lowers intraocular tension, associated or not with glaucoma. (healthician.org)
  • In clinical trials of betaxolol/chlorthalidone combination therapy using betaxolol doses of 5-20 mg and chlorthalidone doses of 12.5-25 mg, the antihypertensive effects increased with increasing doses of either component. (rxlist.com)
  • Therapy with a combination of betaxolol and chlorthalidone will be associated with both sets of dose-independent adverse effects and to minimize these, it may be appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy. (rxlist.com)
  • On the other hand, regimens that combine low doses of betaxolol and chlorthalidone should produce minimal dose-dependent adverse effects, ie, bradycardia and decreases in serum potassium (see CLINICAL PHARMACOLOGY ). (rxlist.com)
  • A patient whose blood pressure is not adequately controlled with monotherapy using either betaxolol (usually 10-20 mg) or chlorthalidone may be switched to Kerledex 5/12.5 mg. (rxlist.com)
  • Subsequent titration (14-day intervals) could add additional betaxolol, chlorthalidone, or both, using single entity products, Kerledex 5/12.5, or Kerledex 10/12.5 as appropriate. (rxlist.com)
  • Are you using betaxolol eyedrops or the oral medication? (healthtap.com)
  • In this study, we tried to compare the efficacy and safety of betaxolol vs. metoprolol immediately postoperatively in coronary artery bypass grafting (CABG) patients and to determine whether prophylaxy for atrial fibrillation (AF) with betaxolol could reduce hospitalization and economic costs after cardiac surgery. (sigmaaldrich.com)
  • Our trial was open-label, randomized, multicentric enrolling 1352 coronary surgery patients randomized to receive betaxolol or metoprolol. (sigmaaldrich.com)
  • Ophthalmic betaxolol has minimal effect on pulmonary and cardiovascular parameters. (medlibrary.org)
  • Additionally, the action of isoproterenol, a beta stimulant, administered at the end of the study was not inhibited by ophthalmic betaxolol. (medlibrary.org)
  • Betaxolol may be associated with depression &/or short-term memory loss . (healthtap.com)
  • Betoptic eye drops contain the active ingredient betaxolol hydrochloride, which is a type of medicine called a beta-blocker. (netdoctor.co.uk)
  • Summary: We introduce a fast, sensitive, label-free method for the detection of Betaxolol hydrochloride (BH) based on fluorescent dye/graphene oxide (FD/GO) fluorescence sensor. (thefreedictionary.com)
  • Table 1 Summary of drugs used to treat glaucoma Drug, strength and Trade name and Side effects and bottle size preservatives contraindications Betaxolol Betaxolol Beta blockers hydrochloride Benzalkonium Transient discomfort 0.5% 5mL chloride (BC), 25%, Disodium edetate tearing 5%, stinging. (thefreedictionary.com)
  • 1 Commercially available tablets containing 10 or 20 mg of betaxolol hydrochloride contain 8.94 or 17.88 mg of betaxolol, respectively. (drugs.com)
  • Kerledex (betaxolol hydrochloride and chlorthalidone) is a combination product indicated for the treatment of hypertension. (rxlist.com)
  • It combines the activities of betaxolol hydrochloride, a β 1 -selective (cardioselective) adrenergic receptor blocking agent, with chlorthalidone, a monosulfamyl diuretic. (rxlist.com)
  • A simple and sensitive spectrophotometric method has been developed for determination of betaxolol hydrochloride in bulk powder, and its pharmaceutical dosage forms. (ijpsonline.com)
  • The ophthalmic solution of betaxolol hydrochloride is official in the United States Pharmacopoeia, and assayed by high performance liquid chromatographic method [ 3 ]. (ijpsonline.com)
  • In the proposed method, betaxolol hydrochloride is first neutralized with sodium hydroxide, and the librated base is oxidized with sodium periodate to produce formaldehyde [ 14 ]. (ijpsonline.com)
  • Betaxolol hydrochloride USP working standard was procured as a gift sample from Torrent Pharmaceuticals Ltd., Ahmedabad. (ijpsonline.com)
  • Betaxolol hydrochloride (25.0 mg) was accurately weighed and transferred to a 25 ml volumetric flask. (ijpsonline.com)
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  • The present study involved design of mucoadhesive nanoparticulate carrier system containing betaxolol hydrochloride for ocular delivery to improve its corneal permeability and precorneal residence time. (eurekaselect.com)
  • Kunal Jain, R. Suresh Kumar, Sumeet Sood and G. Dhyanandhan, "Betaxolol Hydrochloride Loaded Chitosan Nanoparticles for Ocular Delivery and their Anti-glaucoma Efficacy", Current Drug Delivery (2013) 10: 493. (eurekaselect.com)
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  • Betaxolol Hydrochloride Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. (medlibrary.org)
  • Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular weight of 343.89. (medlibrary.org)
  • 5.6 mg betaxolol hydrochloride equivalent to betaxolol base 5 mg. (medlibrary.org)
  • Betaxolol Hydrochloride, a cardioselective (beta-1-adrenergic) receptor blocking agent, does not have significant membrane-stabilizing (local anesthetic) activity and is devoid of intrinsic sympathomimetic action. (medlibrary.org)
  • When instilled in the eye, Betaxolol Hydrochloride Ophthalmic Solution has the action of reducing elevated as well as normal intraocular pressure, whether or not accompanied by glaucoma. (medlibrary.org)
  • Betaxolol Hydrochloride Ophthalmic Solution has the action of reducing elevated as well as normal intraocular pressure, and the mechanism of ocular hypotensive action appears to be a reduction of aqueous production as demonstrated by tonography and aqueous fluorophotometry. (medlibrary.org)
  • The onset of action with Betaxolol Hydrochloride Ophthalmic Solution can generally be noted within 30 minutes and the maximal effect can usually be detected 2 hours after topical administration. (medlibrary.org)
  • Clinical observation of glaucoma patients treated with Betaxolol Hydrochloride Ophthalmic Solution for up to three years shows that the intraocular pressure lowering effect is well maintained. (medlibrary.org)
  • Clinical studies show that topical Betaxolol Hydrochloride Ophthalmic Solution reduces mean intraocular pressure 25% from baseline. (medlibrary.org)
  • In trials using 22 mmHg as a generally accepted index of intraocular pressure control, Betaxolol Hydrochloride Ophthalmic Solution was effective in more than 94% of the population studied, of which 73% were treated with the beta blocker alone. (medlibrary.org)
  • Betoptic ® Pilo Ophthalmic Suspension contains betaxolol hydrochloride, a cardiovascular (beta 1 ) adrenoceptor antagonist and pilocarpine hydrochloride, a cholinergic parasympathomimetic agent. (rxdrugsinfo.com)
  • Betaxolol hydrochloride is a white, crystalline powder. (rxdrugsinfo.com)
  • Betoptic ® Pilo Ophthalmic Suspension is prepared by affixing a one-inch, blunt, 27 gauge cannula (supplied) to the syringe containing the pilocarpine hydrochloride solution and adding the entire contents of the syringe through the opening in the dropper tip to the DROP-TAINER ® containing the betaxolol suspension and mixing well. (rxdrugsinfo.com)
  • In this prospective randomized parallel study we compared the effects of topical timolol maleate, levobunolol hydrochloride and betaxolol hydrochloride on intraocular pressure (IOP) in the patients of primary open angle glaucoma after 16 weeks of instillation as 1 drop 12 hourly in 0.5% concentration. (who.int)
  • Patients were randomized to either laser trabeculoplasty plus topical betaxolol hydrochloride (n = 129) or no initial treatment (n = 126). (nih.gov)
  • Ocular irritation was reported by 1 (1.35%) patient on timolol + bimatoprost, 1 (1.35%) on timolol + acetazolamide, 2 (2.70%) on betaxolol , and 1 (1.35%) patient on bimatoprost had reported ocular stinging. (thefreedictionary.com)
  • betaxolol (Betoptic), carteolol (Ocupress), levobunolol (Betagan), and metipranolol, but there are two case reports for timolol (Betimol, Istalol, Timoptic, Timoptic-XE) showing no fetal harm in one newborn and growth restriction in the other. (thefreedictionary.com)
  • betaxolol was prescribed less frequently because it being a selective [[beta].sub.1]-blocker is less effective and levobunolol though comparable to timolol is expensive. (thefreedictionary.com)
  • Ophthalmic betaxolol (one drop in each eye) was compared to timolol and placebo in a three-way crossover study challenging nine patients with reactive airway disease who were selected on the basis of having at least a 15% reduction in the forced expiratory volume in one second (FEV 1 ) after administration of ophthalmic timolol. (medlibrary.org)
  • No evidence of cardiovascular beta-adrenergic blockade during exercise was observed with betaxolol in a double-masked, three-way crossover study in 24 normal subjects comparing ophthalmic betaxolol, timolol and placebo for effect on blood pressure and heart rate. (medlibrary.org)
  • To evaluate the effects of two beta-adrenergic blocking agents on cardiopulmonary function, we investigated two topical ophthalmologic preparations, betaxolol 1% and timolol 0.5%, in nine patients (eight men and one woman, ranging in age from 25 to 69 years) with reactive airway disease. (princeton.edu)
  • Eye drops that contain beta blockers include betaxolol (Betoptic), cartelol (Ocupress), and timolol (Timoptic). (encyclopedia.com)
  • This study evaluated the effects of the topical β-adrenergic antagonist betaxolol and the non-selective β-adrenergic antagonist timolol on the choroidal pressure-flow relationship. (uthscsa.edu)
  • Choroidal pressure-flow curves were obtained before and 30 min after topical application of 0.1 ml of betaxolol (Betoptic, 0.5%, n = 10), timolol (Timoptic, 0.5%, n = 10) or saline (n = 8) by varying the MAP without controlling the IOP and by raising IOP while holding the MAP constant at 70 mmHg. (uthscsa.edu)
  • The IOP was significantly reduced by betaxolol and timolol but not by Saline. (uthscsa.edu)
  • MAP was also slightly, but significantly, reduced after betaxolol but not after timolol or saline. (uthscsa.edu)
  • However, the systemic hypotensive response to isoproterenol (8 μg/kg, i.v.) was blunted after betaxolol and timolol indicating appreciable systemic absorption of both drugs. (uthscsa.edu)
  • Timolol, but not betaxolol or saline, caused a significant, small increase in baseline choroidal vascular resistance. (uthscsa.edu)
  • We conclude that both drugs reach the systemic circulation after topical application, but neither betaxolol nor timolol alter the choroidal response to acute changes in perfusion pressure. (uthscsa.edu)
  • Kiel, JW & Patel, P 1998, ' Effects of timolol and betaxolol on choroidal blood flow in the rabbit ', Experimental Eye Research , vol. 67, no. 5, pp. 501-507. (uthscsa.edu)
  • 23 eyes of 16, 19 eyes of 12 and 20 eyes of 12 patients were included in timolol, levobunolol and betaxolol groups respectively. (who.int)
  • 1 mmHg with timolol, betaxolol and befunolol therapy respectively. (who.int)
  • 11) Beta blockers Acebutolol (Sectral), atenolol Decreases the force (Tenormin), betaxolol of the heart's (Kerlone), metoprolol contraction and its (Lopressor), atenolol overall heart rate, (Tenormin), bisoprolol (Concor) thus reducing the and pindolol (Visken) heart's demand for oxygen. (thefreedictionary.com)
  • Cardiosseletivos Nao seletivos Drogas com atividade al antagonista adicional Acebutolol * Alprenolol * Bucindolol Atenolol Carteolol * Carvedilol Betaxolol Nadolol Labetalol Bevantolol Oxprenolol * Bisoprolol Penbutolol * Celiprolol Pindolol * Esmolol Propranolol Metoprolol Sotalol Practolol * Timolol Quadro 4: Criterios usados na selecao e forma de obtencao dos dados. (thefreedictionary.com)
  • Do not stop taking betaxolol without talking to your doctor. (medlineplus.gov)
  • If you suddenly stop taking betaxolol, your blood pressure may increases and you may develop new or worsening chest pain. (medlineplus.gov)
  • If you experience such symptoms, stop taking betaxolol and call your doctor immediately. (wholehealthmd.com)
  • As with all oral beta blockers, you should not abruptly stop taking betaxolol tablets, as serious problems (including heart attacks ) may result. (emedtv.com)
  • Take betaxolol at around the same time every day. (medlineplus.gov)
  • Take betaxolol exactly as directed. (medlineplus.gov)
  • Continue to take betaxolol even if you feel well. (medlineplus.gov)
  • Your doctor may tell you not to take betaxolol if you have heart failure or other heart problems. (medlineplus.gov)
  • How should I take betaxolol? (cigna.com)
  • If you have heart failure, your healthcare provider may need to monitor you very closely while you take betaxolol. (emedtv.com)
  • If you will be having surgery, make sure your surgeon and anesthesiologist know you take betaxolol, as it may affect the choice of medications used during the surgery. (emedtv.com)
  • Common questions and answers about can become i now take betaxolol with maprotiline. (sbolot.org)
  • Betaxolol eye drops may cause side effects. (medlineplus.gov)
  • Betaxolol eye drops are also available without a brand name, ie as the generic medicine. (netdoctor.co.uk)
  • This can be a problem even for betaxolol eye drops. (emedtv.com)
  • betaxolol may be used with other eye drops to control high pressure within the eye. (iodine.com)
  • Betaxolol eye-drops, conversely, caused no decrease in airflow in the same patients with proven airway disease. (princeton.edu)
  • However, there are some minor side-effects likely to occur using Betaxolol eye drops such as redness and swelling in eyes, dizziness and a minor headache. (usdrugsmart.com)
  • Tell your doctor if you have ever had any unusual or allergic reaction to betaxolol or any other medicines. (drugs.com)
  • Using betaxolol during pregnancy could harm the unborn baby, or cause heart or lung problems in the newborn baby. (cigna.com)
  • Betoptic (betaxolol) is FDA pregnancy category C. This means it has not been studied adequately in human pregnancies. (healthtap.com)
  • FDA pregnancy category C. It is not known whether betaxolol ophthalmic is harmful to an unborn baby. (livingcountryside.org.uk)
  • Betaxolol is considered a pregnancy Category C medication. (emedtv.com)
  • This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Betaxolol and Pregnancy ) . (emedtv.com)
  • Betaxolol is used alone or together with other medicines (such as hydrochlorothiazide) to treat high blood pressure (hypertension). (drugs.com)
  • Betaxolol is used to treat hypertension (high blood pressure). (cigna.com)
  • Betaxolol is effective in the treatment of hypertension in once-daily doses of 5-20 mg, while chlorthalidone is effective in doses of 12.5-50 mg. (rxlist.com)
  • The release of the Ocular Hypertension Pipeline Review , H2 2014 was encouraging for ophthalmologic research and development teams regarding the use of Betaxolol to treat ocular hypertension. (lgmpharma.com)
  • The review, published in early 2015, focused on the positive aspects of various therapies for treating ocular hypertension, with Betaxolol receiving positive feedback. (lgmpharma.com)
  • Over 1800 patients were enrolled in the OHTS (Ocular Hypertension Treatment Study) and the safety and effectiveness of Betaxolol was determined. (lgmpharma.com)
  • With between four and eight percent of the U.S. population of adults over age forty having a diagnosis of ocular hypertension, the use of an easy to administer, twice daily eye drop like Betaxolol is prudent for both patients and practitioners alike. (lgmpharma.com)
  • Genetic aspects of individual sensitivity to betaxolol in patients with arterial hypertension]. (cdc.gov)
  • Association of polymorphism of b1-adrenoreceptors gene and cytochrome 2D6 gene with efficacy of b-adrenoblocker betaxolol was studied in 81 patients with I and II degree arterial hypertension. (cdc.gov)
  • Thus efficacy of betaxolol in patients with hypertension was associated solely with genotype of polymorphic marker Ser34Pro of CYP2D6 gene. (cdc.gov)
  • and Part II - a DROP-TAINER ® containing betaxolol 0.313%, poly(styrene-divinyl benzene) sulfonic acid, carbomer 934P, boric acid, mannitol, edetate disodium, benzalkonium chloride, sodium hydroxide (pH 8.0 ± 0.2) and purified water to 6.4 mL. (rxdrugsinfo.com)
  • Lifelong therapy with betaxolol may be necessary. (wholehealthmd.com)
  • In patients having in genotype Pro allele of polymorphic marker Pro34Ser of CYP2D6 gene therapy with betaxolol is more effective, than in homozygote carriers of Ser allele. (cdc.gov)
  • We sought a possible correlation between genotype at codon 389 of this receptor with clinical response to topical 0.25% betaxolol (Betoptic-S, Alcon) in a small, pilot study of normal volunteers. (arvojournals.org)
  • BETOPTIC (betaxolol) Ophthalmic Solution is contraindicated in patients with sinus bradycardia, greater than a first degree atrioventricular block, cardiogenic shock , or patients with overt cardiac failure. (healthtap.com)
  • tell your doctor and pharmacist if you are allergic to betaxolol, any other medications, or any of the ingredients in betaxolol tablets. (medlineplus.gov)
  • Ophthalmic betaxolol comes as a solution (liquid) and a suspension (liquid) to instill in the eyes. (medlineplus.gov)
  • Ophthalmic betaxolol is usually used twice a day. (medlineplus.gov)
  • In this small, pilot series, the response rate to ophthalmic betaxolol in normal volunteers was 30%, and the mean decrease in IOP was 2.1 mmHg. (arvojournals.org)
  • Ophthalmic betaxolol has minimal effect on pulmonary and cardiovascular parameters. (medlibrary.org)
  • Additionally, the action of isoproterenol, a beta stimulant, administered at the end of the study was not inhibited by ophthalmic betaxolol. (medlibrary.org)
  • Are you using betaxolol eyedrops or the oral medication? (healthtap.com)
  • Betaxolol and placebo eyedrops produced no significant change from control values. (princeton.edu)
  • Randomized, double-blind, crossover, placebo-controlled comparison of propranolol and betaxolol in the treatment of neuroleptic-induced akathisia. (thefreedictionary.com)
  • if you are using another topical eye medication, instill it at least 10 minutes before you instill betaxolol. (medlineplus.gov)
  • Twenty-three normal volunteers were placed on topical betaxolol for 6 weeks. (arvojournals.org)
  • Betaxolol is available in 0.5 % eye drop and is known as the brand name Betoptic, which is marketed by Alcon Laboratories. (lgmpharma.com)
  • After five and eight days of dosing with Betoptic ® Pilo Ophthalmic Suspension TID, plasma levels of betaxolol were below the level of quantification (2.0 ng/mL) indicating that TID dosing results in a low systemic exposure to the drug. (rxdrugsinfo.com)
  • Betaxolol may also be used for purposes not listed in this medication guide. (cigna.com)
  • Yes, Betoptic (betaxolol) is a prescription medication. (healthtap.com)
  • Labeled Betaxolol, an antihypertensive, and an antiglaucoma. (scbt.com)
  • Literature survey reveals that betaxolol is estimated in pharmaceuticals and biological fluids by HPLC [ 6 - 12 ] and spectropotometric methods [ 13 ]. (ijpsonline.com)
  • The overall effect of betaxolol is to reduce the inflow of aqueous humour into the eyeball, which decreases the pressure within the eye. (netdoctor.co.uk)
  • What is the generic form of Betoptic (betaxolol)? (healthtap.com)
  • caprolactone and poly ethylene glycol for betaxolol delivery was compared and was found that poly-acaprolactone nanoparticles yielded highest pharmacological activity and the factor thought to be responsible for this good performance was agglomeration of the particles. (thefreedictionary.com)