The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.
An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.
Any woven or knit material of open texture used in surgery for the repair, reconstruction, or substitution of tissue. The mesh is usually a synthetic fabric made of various polymers. It is occasionally made of metal.
Surgical procedures undertaken to repair abnormal openings through which tissue or parts of organs can protrude or are already protruding.
Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.
A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Available manpower, facilities, revenue, equipment, and supplies to produce requisite health care and services.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contains IRON and MOLYBDENUM.
Functional competence of specific organs or body systems of the FETUS in utero.
A country spanning from central Asia to the Pacific Ocean.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons; vehicles for medicinal substances intended for external application; there are four classes: hydrocarbon base, absorption base, water-removable base and water-soluble base; several are also emollients.
A colloidal system of semisolid hydrocarbons obtained from PETROLEUM. It is used as an ointment base, topical protectant, and lubricant.
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
Exclusive legal rights or privileges applied to inventions, plants, etc.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Lipid-laden macrophages originating from monocytes or from smooth muscle cells.

Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema. (1/23)

OBJECTIVE: To determine whether a three day burst of a potent corticosteroid is more effective than a mild preparation used for seven days in children with mild or moderate atopic eczema. DESIGN: Randomised, double blind, parallel group study of 18 weeks' duration. SETTING: 13 general practices and a teaching hospital in the Nottingham area. PARTICIPANTS: 174 children with mild or moderate atopic eczema recruited from general practices and 33 from a hospital outpatient clinic. INTERVENTIONS: 0.1% betamethasone valerate applied for three days followed by the base ointment for four days versus 1% hydrocortisone applied for seven days. MAIN OUTCOME MEASURES: Primary outcomes were total number of scratch-free days and number of relapses. Secondary outcomes were median duration of relapses, number of undisturbed nights, disease severity (six area, six sign atopic dermatitis severity scale), scores on two quality of life measures (children's life quality index and dermatitis family impact questionnaire), and number of patients in whom treatment failed in each arm. RESULTS: No differences were found between the two groups. This was consistent for all outcomes. The median number of scratch-free days was 118.0 for the mild group and 117.5 for the potent group (difference 0.5, 95% confidence interval -2.0 to 4.0, P=0.53). The median number of relapses for both groups was 1.0. Both groups showed clinically important improvements in disease severity and quality of life compared with baseline. CONCLUSION: A short burst of a potent topical corticosteroid is just as effective as prolonged use of a milder preparation for controlling mild or moderate atopic eczema in children.  (+info)

Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients. (2/23)

Melasma is an acquired symmetric hypermelanosis characterized by irregular light-to gray-brown macules and patches on sun-exposed areas. Many therapeutic agents are available but are unsatisfactory. Recently, it has been demonstrated that lincomycin (LM) and linoleic acid (LA) can inhibit melanogenesis in vitro. Our purpose was to investigate the clinical efficacy of topical application of LM and LA in combination with betamethasone valerate (BV) in melasma patients. Forty-seven Korean female adults with clinically diagnosed melasma were enrolled in a 6-week, double-blind, randomized clinical trial. Patients were treated with one application of the vehicle (group A), 2% LM mixed with 0.05% BV (group B), or 2% LM mixed with 0.05% BV and 2% LA (group C) on the face every night. Determination of efficacy was based on the Melasma Area and Severity Index (MASI) score and objective assessment (no effect, mild, moderate, or excellent) at intervals of 2 weeks until the end of the study at 6 weeks. After 6 weeks, in comparison with the pre-treatment MASI score, the average MASI score of group C decreased to 68.9%, compared with 98% in group A (p<0.05) and 85.4% in group B. There was no statistically significant difference between group A and group B. Seven patients (43.7%) in group C revealed more than moderate improvement in objective assessment, compared with none in group A and two patients (12.5%) in group B. There were no significant side effects. Topical application of linoleic acid is considered to be effective in the treatment of melasma patients.  (+info)

The combined effect of topical CX-659S, a novel diaminouracil derivative, with topical corticosteroid on the three types of allergic responses in mice or guinea pigs. (3/23)

CX-659S ((S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-ph enyl-2,4(1H,3H)-pyrimidinedione), a newly discovered anti-inflammatory compound, exerts inhibitory effects against picryl chloride-, oxazolone-, and dinitrochlorobenzene-induced acute contact hypersensitivity responses (CHRs) characterized by Th1-type reactions. Furthermore, this compound suppressed chronic CHRs characterized by Th2-type reactions, which is well known to mimic many, if not all, events occurring within the lesional skin of patients with atopic dermatitis (AD). The present study was conducted to determine the combined effect of topical CX-659S with topical corticosteroid on immediate type (ITR), late type (LTR), and delayed type hypersensitivity (DTHR) allergic reactions that are involved in AD. An ineffective dose of CX-659S (0.03 mg/ear) combined with betamethasone valerate (BV) significantly potentiated inhibitory activity of BV alone (0.1 micro g/ear and 0.3Shizuokag/ear) on both the ITR and the LTR in mice with the ovalbumin (OVA)-induced biphasic cutaneous reaction. Furthermore, the combined effect of CX-659S with BV was also observed on dinitrochlorobenzene (DNCB)-induced DTHR in guinea pigs. These results indicate that CX-659S has a combined effect with corticosteroids on every ITR, LTR, and DTHR. Proper treatment with corticosteroids for a safe and effective treatment of AD is needed. Thus, the combination therapy of topical CX-659S with topical corticosteroid would be one of the potential approaches for devising a proper treatment with corticosteroids.  (+info)

Lichen sclerosus and acute urinary obstruction. (4/23)

A case of acute urinary obstruction due to early lichen sclerosus disease is described. In this case both histological corroboration and efficacy of potent topical steroid have been beneficial.  (+info)

Novel quantitative immunofluorescent technique reveals improvements in epidermal cell populations after mild treatment of psoriasis. (5/23)

A novel antibody labelling technique, the Zenon technique, was used in fluorescent immunohistochemistry for a better characterization of epidermal cell populations in a quantitative approach. With this technique, differences in proliferation and differentiation characteristics were shown between psoriatic and normal epidermis. The sensitivity of the method was investigated by assessing the effect of a mild topical treatment versus an emollient. Frozen sections of non-treated psoriatic epidermis and psoriatic epidermis treated once daily with either an emollient or betamethasone-17-valerate for only 2 weeks were compared immunohistochemically. Antibodies against keratin 6, 10 and 15 were labelled with the Zenon technique, whereas antibodies against the Ki-67 antigen and beta-1 integrin were covalently FITC-labelled. Using image analysis, these markers were measured in the epidermis in a standardized manner. Treatment of psoriasis with short-term topical steroid resulted towards normalization of Ki-67 antigen, beta-1 integrin, keratin 10 and keratin 6 expression, which are parameters for proliferation and differentiation. Although treatment with an emollient showed hardly any clinical response, changes towards a more normal phenotype could already be detected in several epidermal markers using this method.  (+info)

An efficient new formulation of fusidic acid and betamethasone 17-valerate (fucicort lipid cream) for treatment of clinically infected atopic dermatitis. (6/23)

To relieve the dryness of atopic dermatitis skin, a lipid formulation of fusidic acid and betamethasone 17-valerate (Fucicort Lipid cream) was developed as an additional treatment option to the established Fucicort cream. The two formulations were compared in patients with clinically infected atopic dermatitis. A total of 629 patients were randomized to twice daily double-blind treatment for 2 weeks with either Fucicort Lipid cream, Fucicort cream, or the new lipid cream vehicle. Clinical assessment was based on a Total Severity Score of the eczematous lesions. Bacteriological samples were taken at inclusion and at subsequent visit(s) if clinically infected lesions persisted. At the end of treatment, the mean reduction in Total Severity score was 82.9% in the lipid cream group, 82.7% in the cream group, and 33.0% in the vehicle group. The percentage of patients with a successful bacteriological response was 89.7%, 89.6% and 25.0%, respectively. Thus, the clinical and anti-bacterial effect of the lipid cream was found to be similar to that of the established cream formulation, and significantly better than that of the vehicle. The new lipid formulation, therefore, offers an efficient, safe and well-tolerated alternative for the short-term treatment of clinically infected atopic dermatitis.  (+info)

Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice. (7/23)

This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-886 (10 mg/kg), and the glucocorticoid betamethasone 17-valerate (3 mg/kg) inhibited the scratching. The scratching was not affected by the cyclooxygenase inhibitors indomethacin and ketoprofen, the TP prostanoid receptor antagonist SQ-29548, the leukotriene B(4) antagonist ONO-4057, the cysteinyl leukotriene antagonist pranlucast, the leukotriene D(4) antagonist MK-571, the platelet-activating factor antagonist CV-3988, the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester, the H(2) histamine-receptor antagonist cimetidine, the H(1) histamine-receptor antagonist terfenadine plus cimetidine, and cypoheptadine that blocks the 5-HT(1/2) serotonin receptors. Zileuton (100 mg/kg) inhibited the increased activity of the cutaneous nerve branch induced by an intradermal injection of the extract, suggesting the peripheral action. Zileuton and MK-886 (10 and 100 microM) did not affect high K(+)-induced increase in intracellular Ca(2+) concentration in cultured dorsal root ganglion neurons. The results suggest that 5-lipoxygenase metabolite(s) other than leukotriene B(4) and cysteinyl leukotrienes are involved in mosquito allergy-associated itching.  (+info)

The influence of sodium hyaluronate, L-leucine and sodium taurocholate on the nebulization of aqueous betamethasone-17-valerate suspensions. (8/23)

 (+info)

Using BETAMETHASONE VALERATE SCALP LOT 0.1% during pregnancy may raise the risk of children developing some disorder (commpon for some such kind of drugs), however it depends upon how BETAMETHASONE VALERATE SCALP LOT 0.1% ingredients pass through placenta and may have effect on baby - Strength of BETAMETHASONE VALERATE SCALP LOT 0.1% is major factor in determination of such side effects, The possible danger in pregnancy are under research. ERN S.A. Canada publish leaflet about BETAMETHASONE VALERATE SCALP LOT 0.1% every update to describe possible risks of using BETAMETHASONE VALERATE SCALP LOT 0.1% side effect in pregnancy and pregnant women. You may download ERN S.A. issued leaflet regarding side effects of BETAMETHASONE VALERATE SCALP LOT 0.1% - BETAMETHASONE 17-VALERATE. Pregnancy Side Effects can be easily know by Atc code of BETAMETHASONE VALERATE SCALP LOT 0.1% ATC CODE.. ...
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Betamethasone valerate foam may be prescribed if you have scalp psoriasis or certain other skin conditions. This eMedTV page gives an overview of betamethasone valerate foam, with information on how to use it and other conditions it can treat.
Betamethasone Valerate (Betamethasone 17-Valerate) Hormone 2152-44-5 1.Quick Details: Other Name:VALISONE;Betamethasonevalerateester;betnovateat;celestoderm; CAS NO.: 2152-44-5 Assay: 98% Molecular Formula:C27H37FO6 Molecular...
Once daily application of diflorasone diacetate ointment compared with betamethasone valerate ointment twice daily in patients with eczematous dermatoses. - K Hersle, H Mobacken
Product Name Betamethasone Valerate CAS No. 2152-44-5 Assay (on dried basis) 97.0% to 103.0% Specification USP/EP/BP Certificates and Documents GMP Appearance Almost white crystalline powder Grade Pharma Grade Type Antiinflammatory steroids...
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
National Drug Code 0061-0387-03 is assigned to otomax with active ingredient(s) gentamicin sulfate, betamethasone valerate, and clotrimazole and is labeled by Merck Sharp & Dohme Corp.
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SCRIPT is an award-successful course designed to train foundation level medical doctors and different healthcare professionals to prescribe safely and effectively. Well being Canada has set even stricter bioequivalence necessities for just a few medicine which might be highly toxic or have a slender therapeutic vary. For some fucicort important dose drugs, akin to these used to deal with seizures or arrhythmias, there have been anecdotal stories of variations between brand identify and generic medication. Both group may change the generic drug companies they work with, which might additionally result in receiving fucicort tablets which can be a distinct color, form or measurement, says Vaida. For slim-therapeutic-vary medications such as blood thinners, antiseizure medicine or thyroid medicines, our medical consultants suggest staying on a generic drug made by one producer. Cheapest generic fucicort 10mg. fucicort Cheap fucicort yahoo ...
PRECAUTIONS Identification of infecting organisms should be made either by microscopic roll smear evaluation or by culture as appropriate. Antibiotic susceptibility of the pathogenic organism(s) should be determined prior to use of this preparation.. If overgrowth of nonsusceptible bacteria, fungi, or yeasts occur, or if hypersensitivity develops, treatment should be discontinued and appropriate therapy instituted.. Administration of recommended doses of OTOMAX ointment beyond 7 days may result in delayed wound healing. Avoid ingestion. Adverse systemic reactions have been observed following the oral ingestion of some topical corticosteroid preparations. Patients should be closely observed for the usual signs of adrenocorticoid overdosage which include sodium retention, potassium loss, fluid retention, weight gain, polydipsia, and/or polyuria. Prolonged use or overdosage may produce adverse immunosuppressive effects.. Use of corticosteroids, depending on dose, duration, and specific steroid, may ...
Alpider information about active ingredients, pharmaceutical forms and doses by Velka Hellas, Alpider indications, usages and related health products lists
Whole grains can be consumed in moderate quantities, and should be limited to less psoriasis monoclonal antibody therapy in cancer 20% of your diet. Chinese Herbs are usually the treatment of choice for skin problems, and there are specific herbs that benefit each kind of category of skin disorder. To avoid infection, keep toenails short, discard old footwear and dont go barefoot around public showers and pools. Our Trade partnership with the family farms have provided them with job opportunities, while providing The Body Shop with skin care products, including our #1 best-selling Hemp Hand Protector. The dose is 3 mg per kilogram for rheumatoid arthritis and 5 mg per kilogram for spondyloarthropathy or inflammatory bowel disease.
Betnovate Scalp Application information about active ingredients, pharmaceutical forms and doses by GlaxoSmithKline, Betnovate Scalp Application indications, usages and related health products lists
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Product Name: Estradiol Valerate Tablets. Common Name: Altadiol, Deladiol, Delestrogen, Estraval, Progynova, Valergen. Strength: 2mg. Description:. Estradiol valerate or oestradiol valerate , is a synthetic ester, of the natural estrogen.. Upon ingestion, regardless of the route of administration, estradiol valerate behaves as a prodrug, being cleaved by esterases in blood plasma and the liver into estradiol and valeric acid. However, compared to estradiol itself, estradiol valerate is absorbed more slowly and possesses a longer duration, especially when given in an oil solution via intramuscular injection (in which it acts as a depot).. Indications and Usage:. Estradiol Valerate treats certain symptoms of menopause (eg, hot flashes, vaginal itching, burning, or dryness). It is used to treat low levels of estrogen caused by certain conditions. It may be used to treat certain types of prostate cancer (advanced androgen-dependent).. Estradiol valerate is a female estrogen hormone. It works by ...
The drug brand named Vabeta contains generic salt - Betamethasone Valerate and is manufactured by Edol.Vabeta is mainly associated with symptoms and indications - The International Classification of Diseases (ICD) - D07AC01 - Betamethasone ...
Please refer to Annex A for photos of some of the products and Annex B for more information on the medicinal ingredients found in the products.. UNDECLARED POTENT INGREDIENTS FOUND IN CREAMS USED IN CHILDREN 3 An infant developed Cushings syndrome following the use of an unlabelled diaper cream for diaper rash. The product was purchased from a traditional practitioner in Malaysia and tested to contain betamethasone valerate (a potent steroid) and clotrimazole (an antifungal medicine). Her symptoms, caused by the steroid, included moon-face, buffalo hump on the back (due to fat accumulation), excessive hair growth on the body and thinning of the skin. The steroid also led to recurrent infections as it suppressed her immune system and caused poor developmental growth. The infant was hospitalised although she has since been discharged and is currently undergoing outpatient treatment.. 4 A mother who purchased DSplendid Kidzema Cream for her childs eczema observed that it cleared up after ...
Otomax Ointment for dogs is a steroidal, antibacterial, and antifungal cream used to treat canine ear infections, both acute and chronic, that are associated with yeast and certain bacteria. Its generic equivalent is Gentamicin Sulfate Veterinary, Betamethasone Valerate, USP and Clotrimazole, USP.
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Perrigo announced it has begun commercial shipments of Betamethasone Valerate Foam 0.12%, the generic version of Stiefel Laboratories Luxiq Foam.
Placebo -Overall, 1185 patients participated in eight placebo controlled trials of calcipotriol. At six and eight weeks calcipotriol was more effective than placebo in adults (figure and figs A and B on website). At eight weeks in one trial the rate ratio was 2.9 (95% confidence interval 1.7 to 5.0) in the patients overall assessment of response, and the mean difference in the percentage change in scores on the psoriasis area and severity index was 44.1% (27.8% to 60.4%)w5. Based on the results of one trial calcipotriol was no better than placebo in childrenw6.. Topical corticosteroids -Calcipotriol was significantly more effective than potent topical corticosteroids at six weeks but not at eight weeks. In two trials the pooled mean difference in the percentage change in scores on the psoriasis area and severity index at six weeks was 6.5% (2.4% to 10.6%) (figure)w9 w10. Calcipotriol was also as effective as very potent topical corticosteroids. In two trials the pooled mean difference in the ...
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A single dose of IL-4R appears safe and effective in moderate asthma. The 1,500 microg dose appears as safe but significantly more effective than the 500 microg dose.
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Progynova (Estradiol Valerate Tablets) is used as a Hormone Replacement Therapy (HRT) for the treatment of menopausal complaints after the cessation of monthly bleeding, or after surgical removal of the ovaries.
Paddock Laboratories, Inc.: Estradiol Valerate Injection is indicated in the: Treatment of moderate to severe vasomotor symptoms associated with the menopause...
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ALVE S, ANDRéS; STEINFELD, PABLO; PASTORINI, JORGE y GIACHETTO, GUSTAVO. Esteroides tópicos como tratamiento conservador de la fimosis. Arch. Pediatr. Urug. [online]. 2004, vol.75, n.4, pp.327-330. ISSN 1688-1249.. Introduction: phimosis is defined as the foreskin incapacity to be retracted at an age in which is usually retracted. In the last years the topical steroid application has started to be used as an alternative for surgery treatment of phimosis. Objective: to describe the therapeutic response of phimosis to the topical application of betamethasone. Material and method: the therapeutic response to the twice a day topical application of 0,1% betamethasone valerate during 30 days, was evaluated in children with phimosis from 3 to 14 years old, assisted in the Centro de Salud Materno Infantil Maciel, from June 2001 to March 2002. Results: 28 children were included. The median age was 5,6 years. Full recovery was observed in 17 children, improvement in eight and therapeutic failure in ...
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Mitte 15 g and 2 repeats. For further information on applying topical corticosteroids to different body areas, see: www.bpac.org.nz/BPJ/2016/February/eczema.aspx. Caution is required when applying a topical corticosteroid to the face, periorbital or perioral regions and flexural or groin areas. The face, flexural and groin areas are more susceptible to adverse effects such as striae or skin atrophy and systemic absorption is increased in these areas compared to other sites.8, 9 For children with eczema on the face, use mild potency or short courses of moderate potency corticosteroids.8, 10 In flexural or groin areas moderate or potent topical corticosteroids should be used only for short periods, e.g. 7-14 days.8 Topical calcineurin inhibitors (unsubsidised) are an alternative treatment option for application to these sites.8,10 They are more likely to cause a burning sensation and pruritis than topical corticosteroids.11. In periorbital regions potent or very potent topical corticosteroids ...
History: An itchy, erythematous, scaly plaque with an active border involved most of the lower half of the face extending from one cheek across the chin and neck to the other cheek of one year duration. The patient used many topical corticosteroid preparations prescribed by GPs and sometimes by the patient herself. Of these preparations clobetasol propionate (superpotent cs) and betamethasone valerate (potent cs) in cream and ointment bases applied for long periods. She improved partially and transiently on these agents but shortly later deteriorates with extension of the rash each time these agents used to reach the present picture within one year ...
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This is a multi-center, randomized, double-blind, parallel group study. Efficacy Objectives: To evaluate the efficacy of CD2027 ointment 3 mcg/g applied twice daily over 4 weeks versus its vehicle in adult subjects with at least moderate atopic dermatitis.. Safety objective: To evaluate safety of CD2027 ointment 3 mcg/g when applied twice daily over 4 weeks versus its vehicle on 5% - 20% involved BSA (excluding Head/Neck) in adult subjects with at least moderate atopic dermatitis. ...
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This is a Phase IIa, randomized, double-blind, placebo-controlled, intra-individual left-right limb comparison trial to investigate the efficacy, local irritation, safety, tolerability and pharmacokinetics of multiple topical applications of ImCOOH cream. The trial population will consist of 25 patients with moderate atopic dermatitis. Twenty patients will receive a hydrophilic cream containing 10% ImCOOH and a placebo cream randomized over both limbs twice daily for 14 days with an additional morning application on Day 15. Five patients will receive placebo cream on both limbs twice daily for 14 days with an additional morning application on Day 15. The creams will be applied on 2 comparative target areas (minimum 0.1% and maximum 2% of the total body surface area per target area), with one site at the left limb and one site at the right limb. The applied creams needs to be prevented from wiping off. Efficacy will be assessed until Day 15 and safety and tolerability will be monitored until 14 ...
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Beta Val Cream - Betamethasone (bay-ta-METH-a-sone) Valerate is used for Reducing itching, redness, and also for several skin disorders.
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Case presentation A 70-year-old woman presents with a persistent, uncomfortable and slightly eroded submammary rash that has been present for several weeks (Figure 1). She complains of a burning sensation in the rash. The rash has been treated with a potent topical corticosteroid, without improvement. A skin scraping and culture have not shown evidence of a fungal infection.
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Betamethasone has not been well studied during breastfeeding after systemic or topical use. Systemic betamethasone is best avoided in favor of one of the shorter-acting and better studied alternatives because of its potency and low protein binding which would favor its passage into milk. Use of betamethasone 3 to 9 days prior to delivery of a preterm infant might decrease postpartum milk production in some women. Local injections, such as for tendinitis, would not be expected to cause any adverse effects in breastfed infants,[1] but might occasionally cause temporary loss of milk supply.
POEM: Antenatal betamethasone beneficial to late preterm newborns Clinical Question: Does antenatal betamethasone given at 34 to 36 6/7 weeks of gestation improve outcomes for late preterm newborns? Bottom Line: Betamethasone administered to women at risk for late preterm birth reduces newborn respiratory complications, but with an increase in neonatal hypoglycemia. There was no evidence for…
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Two hydrosoluble conjugates of 17β-estradiol (ED) and estradiol-17β-valerate (EV) with polyaspartamide polymer were prepared and characterized. ED and EV were first chemically modified and bound to poly,-(N-2-hydroxyethyl-DL-aspartamide)-poly,-(N-2-aminoethyl-DL-aspartamide) (PAHA), a hydrosoluble polyaspartamide-type copolymer bearing both hydroxyl and amino groups. ED was first converted to 17-hemisuccinate (EDS) and then bound to PAHA. In the resulting conjugate PAHA-EDS, the estradiol moiety was linked to the polymer through a 2-aminoethylhemisuccinamide spacer. On the other hand, EV was first converted to estradiol-17-valerate-3-(benzotriazole-1-carboxylate), which readily reacted with amino groups in PAHA affording the polymer-drug conjugate PAHA-EV. In the prepared conjugate PAHA-EV, the estradiol moiety was covalently bound to the polyaspartamide backbone by carbamate linkage, through an ethylenediamine spacer. The polymer-drug conjugates were designed and ...
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LEMUS, DAVID et al. Antiangiogenic effect of betamethasone on the chick cam stimulated by TA3 tumor supernatant. Biol. Res. [online]. 2001, vol.34, n.3-4, pp.227-236. ISSN 0716-9760. http://dx.doi.org/10.4067/S0716-97602001000300010.. Tumor growth is the result of combined cell proliferation overwhelming cell death and neoangiogenesis. This report shows CAM angiogenesis promoted by TA3 tumor supernatant with or without low dosis of betamethasone (Minimal antiangiogenic concentration: ß-MAAC). Methylcellulose discs instilled with 10 µl of ß-MAAC (0.08 µg/ml),10 µl of tumor supernatant(TA3ts),5 µl ß-MAAC + 5 µl TA3ts, and 10 µl of PBS as control were implanted in host chick eggs. On day 12, the grafts were removed, photographed and fixed. Sections were stained in parallel, one and three with hematoxylin-eosin, and section two by the Tunel method. The number of vessels was evaluated in a microscopic field of the CAM (2250 µm2 ). The results show that ß-MAAC produced a significant ...
In pharmacy, a thermophobic foam consisting of 0.1% betamethasone valerate was found to be at least as effective as ... August 4, 2003). "Efficacy of Betamethasone Valerate 0.1% Thermophobic Foam". Curr Med Res Opin. 19 (4): 342-5. doi:10.1185/ ...
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A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo ... betamethasone valerate ointment. A double-blind, randomized trial". Dermatologica. 170 (4): 195-8. doi:10.1159/000249530. PMID ...
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