DiseasesChemicals and Drugs
BetahistineHistamine AgonistsHistamine H3 AntagonistsMeniere DiseaseVertigoReceptors, Histamine H3MethylhistaminesVestibular DiseasesTinnitus
Betahistine
A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.
Histamine Agonists
Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.
Histamine H3 Antagonists
Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to correct SLEEP WAKE DISORDERS and MEMORY DISORDERS.
Meniere Disease
A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops.
Vertigo
An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
Receptors, Histamine H3
A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Methylhistamines
Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.
Vestibular Diseases
Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.
Tinnitus
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.

A comparison of betahistine hydrochloride with placebo for vertebral-basilar insufficiency: a double-blind study. (1/26)

To test the effectiveness of betahistine HC1 in reducing the frequency of transient ischemic attacks (TIAs) caused by vertebral-basilar artery insufficiency, we randomly assigned 26 patients with a typical history of the condition to a placebo-drug or a drug-placebo sequence, each sequence lasting two months. During the study, the frequency of TIAs did not differ significantly between the placebo and the drug groups. Subjective responses indicated some value for betahistine as a palliative agent.  (+info)

Pre and post betahistine therapy 99m Tc - HMPAO brain spect studies in patients with vertigo. (2/26)

Vertebro basilar insufficiency (VBI) is a well known cause of vertigo. Brain Single Photon Emission Computed Tomography (SPECT) is an important diagnostic tool to detect and to quantitate the perfusion abnormalities in different areas of the brain. Effect of an antivertigo drug Betahistine on improving the hypoperfusion in different areas of the brain in vertigo patients was studied using brain SPECT. Betahistine at a dose of 16 mg three times daily was shown to improve perfusion in the hypoperfused areas of the brain resulting in relief from symptoms of vertigo. The cerebellar region, which is the most important area involved in vertigo patients with vascular pathology, showed almost complete normalisation of perfusion following Betahistine therapy.  (+info)

Betahistine inhibits food intake in rats. (3/26)

Betahistine, administered intraperitoneally, decreased, in a dose-dependent manner and in a statistically significant degree, total food intake in different experimental models in rats.  (+info)

Distribution of cardiac output in dogs during intravenous infusion of betahistine. (4/26)

Cardiac output (CO), arterial blood pressure (ABP), heart rate (HR), blood gases and blood flow (BF) to the brain, heart, kidney and skeletal muscles and other cephalic tissues in five dogs were studied before and at 30 minutes of betahistine infusion (0.12 to 0.2 mg per minute per kilogram). The particle distribution method using radioactive labeled 141Ce (15 mu) and 85Sr (15 mu) microspheres was utilized to quantitate and assess BF and CO. In the five dogs, the increase in CO averaged 20.8%, ABP remained constant, and HR increased in all but one exception where it decreased slightly concomitant with a decrease in Paco2. Brain BF increased (+ 29.6%) in the dogs whose Paco2 reamined constant. The BF increased to the heart (25.4%) and skeletal muslce (80%), while BF to the kidney and other tissues did not change. The change in HR appears to account for the change in CO. The dilating effect of betahistine on blood vessels, in the skeletal muscle, brain and heart could reduce peripheral resistance and decreace ABP. Thus, the increase in HR may be mediated through baroreceptor mechanisms rather than by a direct effect of betahistine. In addition, a decrease in Paco2, is more effective for decreasing cerebral BF than betahistine is for increasing blood flow.  (+info)

Benign paroxysmal positional vertigo: a study of two manoeuvres with and without betahistine. (5/26)

Efficacy of the liberatory manoeuvre and of gradual otolitis dispersion technique, with or without associated drug therapy, have been compared. Included in this prospective study were 103 patients with benign paroxysmal positional vertigo seen in the Outpatient Department. Patients were classified into 4 groups according to treatment: Liberatory Manoeuvre according to methods described by Semont et al., with and without betahistine, Gradual Otolitis Dispersion Technique according to Brandt and Daroff, with and without betahistine. Evaluation was performed at baseline and at 3, 7, 14, 30, 60 and 90 days after start of treatment. Response to treatment was evaluated using criteria of Epley. At day 14, liberatory manoeuvre-betahistine and Brandt and Daroff-betahistine groups did significantly better than liberatory manoeuvre and Brandt and Daroff groups (p < 0.05). Improvement reached at day 30 was: 100% in liberatory manoeuvre-betahistine group; 96.30% (p > 0.05) in Brandt and Daroff-betahistine group; these results were significantly better (p < 0.05) than those of liberatory manoeuvre (54.17%) and Brandt and Daroff (25%) groups. As far as concerns differences between disease onset and start of therapy (less and more than 2 weeks), and age (< or =60 years and > or =60 years), response to treatment was similar. In conclusion, both liberatory manoeuvre and Brandt and Daroff, when associated with betahistine, were significantly more effective than manoeuvres alone (p < 0.05). Improvement in liberatory manoeuvre-betahistine group, in the initial phase, was greater that in Brandt and Daroff-betahistine group, albeit, differences were not significant (p > 0.05). Age-related effects of manoeuvres were compared in 71 patients < 60 years and 32 patients > or =60 years, showing a similar improvement rate at the end of the investigation in both groups. In our opinion, liberatory manoeuvre and Brandt and Daroff associated with betahistamine produces faster recovery compared to liberatory manoeuvre and Brandt and Daroff alone. Nevertheless, 3 months after onset of treatment, all patients showed complete recovery due to spontaneous evolution of paroxysmal positional vertigo, in other words, treatment does not appear to influence the final improvement rate and its role should be accepted as a significant reduction in persistence of symptoms.  (+info)

Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotation. (6/26)

The effects of anti-vertigo drugs on medial vestibular nucleus (MVN) neurons were examined to assess the site and mode of action using cats anesthetized with alpha-chloralose. Single neuron activity in the MVN was extracellularly recorded using a silver wire microelectrode attached along a seven-barreled micropipette, each of which was filled with diphenhydramine, diphenidol, betahistine, glutamate or NaCl. Type I of the MVN neurons were identified according to the responses obtained when the animal placed on a turn-table was rotated sinusoidally. The effects of the drugs were examined on type I neurons which received impulses primarily from the labyrinth and sent them to the oculomotor nuclei. The microiontophoretic application of diphenhydramine, diphenidol and betahistine inhibited rotation-induced firing of type I MVN neurons. Diphenhydramine and diphenidol were more potent than betahistine. These results suggest that these drugs directly act on MVN neurons to reduce the responsiveness to rotatory stimulation.  (+info)

Optimizing the pharmacological component of integrated balance therapy. (7/26)

Drug treatment is an important option for the treatment of peripheral vestibular diseases. AIM: To identify the drug component associated with optimal integrated balance therapy (IBT) for Menieres disease or other peripheral vestibular disorders. MATERIALS AND METHODS: Analysis of a series of patients with Menieres disease patients or patients with other peripheral vestibular disorders that received IBT involving either no medication or betahistine, cinnarizine, clonazepam, flunarizine or Ginkgo biloba during 120 days. RESULTS: In Menieres disease, significant differences were observed for all drug therapies (60 days) versus no medication; betahistine was significantly more effective than all other drugs at 60 and 120 days. For non-Menieres disorders, significant differences were observed among betahistine, cinnarizine, clonazepam and flunarizine and no medication after 60 days; all drug therapies were significantly more effective than no medication after 120 days; betahistine, cinnarizine or clonazepam were equally effective and betahistine was more effective than flunarizine and EGb 761. All treatment options were well tolerated. CONCLUSIONS: Drug therapies were more effective than no medication in the IBT for patients with Menieres disease or other peripheral vestibular disorders. Betahistine was the most effective medication for patients with Menieres disease and was as effective as cinnarizine and clonazepam for other peripheral vestibular disorders.  (+info)

Betahistine in the treatment of vertiginous syndromes: a meta-analysis. (8/26)

Vertigo is a very frequent disorder, associated with highly disabling symptomatology. Since the aetiology cannot always be easily identified, treatment is often addressed to the symptoms. Betahistine, a drug characterized by a multi-factorial mode of action of the modulatory type, has been widely employed in the management of various vertiginous syndromes. Its use in Italy is, currently, authorized to treat the vertiginous symptoms related to Meniere's disease. A meta-analysis has, therefore, been carried out to assess, the efficacy of betahistine in the treatment of other vertiginous syndromes, such as positional paroxysmal vertigo (cupulo-canalolithiasis) and vertigo secondary to arterial deficiency of the vertebrobasilar area, regardless of the specific cause. A review has been made of the literature concerning clinical trials performed with betahistine versus placebo in a randomised double-blind, parallel-group or cross-over design. Only studies evaluating betahistine in patients with vertiginous symptomatology not related to Meniere's disease were selected. Of the 104 publications, obtained from an analysis of "Medline", "EMBASE" and "CINAHL" databases, 7 clinical studies, which met the selection criteria, for a total of 367 patients, were extrapolated and analysed. The meta-analysis was conducted using the "Cochrane Collaboration's Review Manager" software in all the case series and in the sub-groups identified by the experimental design (parallel or crossover design), range of dosages (32-48 mg/day) and range of treatment duration (from 3 weeks to 4 months). The various parameters used to evaluate efficacy, adopted in the trials, and taken into account in the metaanalysis, as overall judgement of the patient or physician, number of vertiginous episodes and their duration, were classified according to the binary classification of "improved" and "not improved". The results of the meta-analysis confirm the therapeutic benefit of betahistine versus placebo. In particular, the investigation carried out on the overall sample shows an odds ratio of 3.52 (95% confidence interval 2.40-5.18) and a relative risk of 1.78 (95% confidence interval 1.48-2.13), while the analysis of the sub-groups denotes a maximum efficacy after doses of 32 to 36 mg and with a period of treatment of 3-8 weeks. The present meta-analysis confirms the benefit of drug treatment with betahistine for the vertiginous symptomatology related to cupulo-canalolithiasis and vertebro-basilar arterial insufficiency.  (+info)

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Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO studyEffectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study
Background Vestibular vertigo is associated with substantially reduced quality of life. Betahistine is effective in improving vertigo-associated symptoms, with longer treatment periods leading to greater improvements; however, it is not known whether these effects persist after treatment cessation. Methods VIRTUOSO was a prospective, multinational, non-comparative, post-marketing observational programme investigating the effectiveness of betahistine (48 mg/day) and the course of vertigo after the discontinuation of treatment. Patients with vestibular vertigo who were prescribed 48 mg/day betahistine were enrolled in Russia and Ukraine. Treatment duration was up to 2 months, and patients were followed up for 2 months after discontinuation of betahistine. Efficacy endpoints included clinical response (assessed by change in vertigo severity), monthly attack frequency, and physician and patient grading of overall clinical response and improvement of vertigo-associated symptoms. Results Overall, 309
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174114
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TY - JOUR. T1 - Detailed statistical analysis plan for the Danish Palliative Care Trial (DanPaCT). AU - Johnsen, Anna Thit. AU - Petersen, Morten Aagaard. AU - Gluud, Christian. AU - Lindschou, Jane. AU - Fayers, Peter. AU - Sjøgren, Per. AU - Pedersen, Lise. AU - Neergaard, Mette Asbjoern. AU - Vejlgaard, Tove Bahn. AU - Damkier, Anette. AU - Nielsen, Jan Bjoern. AU - Strömgren, Annette S. AU - Higginson, Irene J. AU - Groenvold, Mogens. PY - 2014. Y1 - 2014. N2 - BACKGROUND: Advanced cancer patients experience considerable symptoms, problems, and needs. Early referral of these patients to specialized palliative care (SPC) could offer improvements. The Danish Palliative Care Trial (DanPaCT) investigates whether patients with metastatic cancer will benefit from being referred to early SPC. DanPaCT is a multicenter, parallel-group, superiority clinical trial with 1:1 randomization. The planned sample size was 300 patients. The primary data collection for DanPaCT is finished. To prevent ...
https://portal.findresearcher.sdu.dk/en/publications/detailed-statistical-analysis-plan-for-the-danish-palliative-care
Statistical analysis plan for pooled individual patient data from two landmark randomized trials (INTERACT2 and ATACH-II) of...
TY - JOUR. T1 - Statistical analysis plan for pooled individual patient data from two landmark randomized trials (INTERACT2 and ATACH-II) of intensive blood pressure lowering treatment in acute intracerebral hemorrhage. AU - Moullaali, Tom J. AU - Wang, Xia. AU - Martin, Renee H. AU - Shipes, Virginia B. AU - Qureshi, Adnan I. AU - Anderson, Craig S. AU - Palesch, Yuko Y. PY - 2018/11/12. Y1 - 2018/11/12. N2 - BACKGROUND: There is persistent uncertainty over the benefits of early intensive systolic blood pressure lowering in acute intracerebral hemorrhage. In particular, over the timing, target, and intensity of systolic blood pressure control for optimum balance of potential benefits (i.e. functional recovery) and risks (e.g. cerebral ischemia).AIMS: To determine associations of early systolic blood pressure lowering parameters and outcomes in patients with a hypertensive response in acute intracerebral hemorrhage. Secondary aims are to identify the modifying effects of patient characteristics ...
https://www.research.ed.ac.uk/en/publications/statistical-analysis-plan-for-pooled-individual-patient-data-from
Handling oxygenation targets in ICU patients with COVID-19-Protocol and statistical analysis plan in the HOT-COVID trialHandling oxygenation targets in ICU patients with COVID-19-Protocol and statistical analysis plan in the HOT-COVID trial
The HOT-COVID trial will provide patient-important data on the effect of two oxygenation targets in ICU patients with COVID-19 and hypoxia. This protocol paper describes the background, design and statistical analysis plan for the trial.
https://pubmed.ncbi.nlm.nih.gov/34310694/?otool=bibsys
H3 receptor antagonist - WikipediaH3 receptor antagonist - Wikipedia
An H3 receptor antagonist is a classification of drugs used to block the action of histamine at the H3 receptor. Unlike the H1 and H2 receptors which have primarily peripheral actions, but cause sedation if they are blocked in the brain, H3 receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of histamine. Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H1 receptors in the cerebral cortex. Consequently, unlike the H1 antagonist antihistamines which are sedating, H3 antagonists have stimulant and nootropic effects, and are being researched as potential drugs for the treatment of neurodegenerative conditions such as Alzheimers disease. Examples of selective H3 antagonists include clobenpropit, ABT-239, ciproxifan, conessine, A-349,821,, betahistine, and pitolisant. The histamine H3 receptor (H3R) was discovered ...
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3. Drug Mode of Action :: Fexofenadine, an active metabolite of terfenadine, is a competitive peripheral histamine H1-receptor antagonist on effector cells in the GI tract, blood vessels and respiratory tract.. Drug Interactions ::. Co-admin with ketoconazole or erythromycin may increase plasma levels of fexofenadine. May increase adverse effects of other anticholinergics and CNS depressants. May increase arrhythmogenic effect of antipsychotic agents (phenothiazines); avoid concurrent usage. May reduce the efficacy of betahistine. Pramlintide may increase the anticholinergic effect of fexofenadine. Bioavailability may be increased by verapamil. Efficacy may be reduced by rifampin.. ...
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Detailed statistical analysis plan for the pulmonary protection trial | Trials | Full Text
The primary conclusion of the trial will be based on the results of the primary outcome. If the result of the primary outcome is not statistically significant, the conclusion will be that there is no significant difference between the interventions. The results on all other types of outcomes will be reported for hypothesis-generating purposes. However, we will inspect the confidence interval (CI) to asses if the CI for the group difference contains values of importance, so that we cannot rule out interesting differences.. The primary analysis will include a modified intention-to-treat population, which is defined as all randomized patients, except patients who did not receive CPB-dependent cardiac surgery [9]. A secondary analysis will include the per-protocol population excluding patients with major protocol violations defined as: 1) patients who were randomized to an intervention but did not receive any intervention; and 2) patients who received an incorrect intervention. The dependent ...
https://new-trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-15-510
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Energy balance therapy for obesity management - Patent # 7558629 - PatentGenius
Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patients amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patients energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patients stimulation therapy parameters.
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Further Results on Bayesian Method of Moments Analysis of the Multiple Regression ModelFurther Results on Bayesian Method of Moments Analysis of the Multiple Regression Model
In this article we extend previous BMOM results by showing how information about a variance parameter and its relation to regression coefficients produces a rich class of postdata densities for regression parameters. Prediction and model selection techniques are also described. We also discuss the well-documented link between cross-entropy and the average log odds and then use this criterion in an experiment to compare results obtained from BMOM and Bayes approaches using data generated from known models.
https://ideas.repec.org/p/isu/genres/12021.html
Conjoint Associate Professor John Best / Staff Profile / The University of Newcastle, AustraliaConjoint Associate Professor John Best / Staff Profile / The University of Newcastle, Australia
In this fully revised and expanded edition of Smooth Tests of Goodness of Fit, the latest powerful techniques for assessing statistical and probabilistic models using this proven class of procedures are presented in a practical and easily accessible manner. Emphasis is placed on modern developments such as data-driven tests, diagnostic properties, and model selection techniques. Applicable to most statistical distributions, the methodology described in this book is optimal for deriving tests of fit for new distributions and complex probabilistic models, and is a standard against which new procedures should be compared. New features of the second edition include: Expansion of the methodology to cover virtually any statistical distribution, including exponential families. Discussion and application of data-driven smooth tests. Techniques for the selection of the best model for the data, with a guide to acceptable alternatives. Numerous new, revised, and expanded examples, generated using R code. ...
https://www.newcastle.edu.au/profile/john-best
Trade, Investment, and Growth: Nexus, Analysis, and PrognosisTrade, Investment, and Growth: Nexus, Analysis, and Prognosis
This paper looks at the patterns of causation between income, export, import, and investment growth for 25 developing countries. Our approach differs from previous efforts in a number of ways. First, we examine each country individually in order to allow for complete heterogeneity and properly account for the stochastic trending properties of the data. Second, we apply novel model selection techniques which are based on in-sample goodness-of-fit criteria and ex-ante predictive ability criteria to identify the best model for each country. Finally, we propose a rather novel device based on simple contingency tables which allows us to assess whether our models are capable of accurately predicting turning points in GDP growth. We find that countries with high trade exposure fare poorly in this dimension and posit that the GDP growth in such countries is best modeled using an index of global business cycle conditions, in addition to the above variables. Overall, we find that in around two thirds of ...
http://www.nber.org/papers/w6861
Abstract | NBER-NSF Time Series Conference 2009 | University of California, Davis, USAAbstract | NBER-NSF Time Series Conference 2009 | University of California, Davis, USA
Based on the concept of Kolmogorov complexity, algorithmic statistics in a form of a computer program is proposed as an unified way of computing unknown probabilistic or non-probabilistic dynamic structures of high frequency time series data. Popular model selection techniques, such as AIC, BIC and MDL, all are shown not algorithmic statistics due to their computational infeasibility. We then address a fundamental question: Is there an algorithmic statistic that can extract more computable information of dynamic structure than maximum likelihood approach can? We address this question by comparing two algorithmic statistics: Viterbi and Hierarchical Factor Segmentation (HFS) algorithms, for decoding state-space vector under Hidden Markov Model and beyond. We discuss how to apply HFS algorithm to resolve parametric/non-parametric change-point problems without prior knowledge of number of changes as an example of non-probabilistic dynamic structure. We present applications of HFS algorithm on ...
http://nber-nsf09.ucdavis.edu/program/abstract.php?id=27
Evidence of unexplained discrepancies between planned and conducted statistical analyses: a review of randomised trials | BMC...Evidence of unexplained discrepancies between planned and conducted statistical analyses: a review of randomised trials | BMC...
Choosing or altering the planned statistical analysis approach after examination of trial data (often referred to as p-hacking) can bias the results of randomised trials. However, the extent of this issue in practice is currently unclear. We conducted a review of published randomised trials to evaluate how often a pre-specified analysis approach is publicly available, and how often the planned analysis is changed. A review of randomised trials published between January and April 2018 in six leading general medical journals. For each trial, we established whether a pre-specified analysis approach was publicly available in a protocol or statistical analysis plan and compared this to the trial publication. Overall, 89 of 101 eligible trials (88%) had a publicly available pre-specified analysis approach. Only 22/89 trials (25%) had no unexplained discrepancies between the pre-specified and conducted analysis. Fifty-four trials (61%) had one or more unexplained discrepancies, and in 13 trials (15%), it was
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-020-01590-1
BetahistineBetahistine
... is a strong antagonist of the histamine H3 receptor and a weak agonist of the histamine H1 receptor. Betahistine ... Betahistine may also cause several digestive-related side effects. The package insert for Serc, a trade name for betahistine, ... None of the trials showed any effect of betahistine on hearing loss. No serious adverse effects were found with betahistine." ... may be active and exert effects similar to those of betahistine on ampullar receptors. Betahistine chemically is 2-[2-( ...
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TinnitusTinnitus
There is no evidence to suggest that the use of betahistine to treat tinnitus is effective. Botulinum toxin injection has been ... "Betahistine for tinnitus". Cochrane Database of Systematic Reviews. 12 (8): CD013093. doi:10.1002/14651858.CD013093. PMC ...
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Benign paroxysmal positional vertigoBenign paroxysmal positional vertigo
There is tentative evidence that betahistine may help with vertigo, but its use is not generally needed. BPPV is not a serious ... Among them are betahistine or dexamethasone/gentamicin for the treatment of Ménière's disease, carbamazepine/oxcarbazepine for ... Murdin L, Hussain K, Schilder AG (June 2016). "Betahistine for symptoms of vertigo" (PDF). The Cochrane Database of Systematic ...
https://en.wikipedia.org/wiki/Benign_paroxysmal_positional_vertigo
Ménières diseaseMénière's disease
As of 2014, betahistine is often used as it is inexpensive and safe; but evidence does not justify its use in MD. Transtympanic ... James, A. L.; Burton, M. J. (2001). "Betahistine for Menière's disease or syndrome". The Cochrane Database of Systematic ... 2016). "Efficacy and safety of betahistine treatment in patients with Meniere's disease: Primary results of a long term, ...
https://en.wikipedia.org/wiki/Ménière's_disease
Cochlear hydropsCochlear hydrops
While Betahistine is considered safe, there is insufficient evidence that it is an effective treatment. It is not FDA approved ... Betahistine is the most widely prescribed medication for the treatment of Meniere's disease. The drug is thought to increase ... Betahistine at high doses (such as 144 mg/day) can yield similar vertigo control as intratympanic dexamethasone. Antivirals ... 2016). "Efficacy and safety of betahistine treatment in patients with Meniere's disease: Primary results of a long term, ...
https://en.wikipedia.org/wiki/Cochlear_hydrops
Histamine agonistHistamine agonist
H3: Betahistine is a weak Histamine1 agonist and a very strong Histamine3 antagonist (paradoxically histamine increasing). ...
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LabyrinthitisLabyrinthitis
"Betahistine for symptoms of vertigo", in The Cochrane Collaboration (ed.), Cochrane Database of Systematic Reviews, John Wiley ... "Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in ...
https://en.wikipedia.org/wiki/Labyrinthitis
H3 receptor antagonistH3 receptor antagonist
Examples of selective H3 antagonists include clobenpropit, ABT-239, ciproxifan, conessine, A-349,821, betahistine, and ...
https://en.wikipedia.org/wiki/H3_receptor_antagonist
Vestibular nerveVestibular nerve
By administering betahistine to the damaged nerve over a long period of time, the process of vestibular compensation can be ...
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Histamine H3 receptorHistamine H3 receptor
A-349,821 ABT-239 Betahistine (also weak H1 agonist) Burimamide (also weak H2 antagonist) Ciproxifan Clobenpropit (also H4 ...
https://en.wikipedia.org/wiki/Histamine_H3_receptor
List of MeSH codes (D03)List of MeSH codes (D03)
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SERCSERC
... a brand name of the antivertigo drug betahistine State Electricity Regulatory Commissions, in India South Eastern Regional ...
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C8H12N2C8H12N2
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VertigoVertigo
Anticonvulsants such as topiramate or valproic acid for vestibular migraines Antihistamines such as betahistine, dimenhydrinate ...
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List of drugs: BeList of drugs: Be
Betadine Betagan Betahistine (INN) Betaject Betalin 12 Betalin S Betaloc Betameprodine (INN) Betamethadol (INN) Betamethasone ...
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Sensorineural hearing lossSensorineural hearing loss
vitamins and antioxidants vasodilators betahistine (Betaserc), an anti-vertigo drug hyperbaric oxygen rheologic agents that ...
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There are 2 types of salt formulated for betahistine namely mesilate & dihydrochloride ... Betahistine - What is it for. ​Betahistine is used to treat vertigo (dizzy spells), tinnitus (ringing in the ear), hearing loss ... Betahistine - Additional Information. ​The symptoms of a drug allergy include one or more of the following: *Swollen face/eyes/ ... There are two types of salt formulated for betahistine namely mesilate and dihydrochloride. ...
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Betahistine (SERC) and Breastfeeding - InfantRisk Forums Betahistine (SERC) and Breastfeeding - InfantRisk Forums
A mother receives Betahistine (SERC) 24 mg 1 tablet 2 times a day. It was categorized as L4 in Hales Medications and Mothers ... A mother receives Betahistine (SERC) 24 mg 1 tablet 2 times a day. It was categorized as L4 in Hales Medications and Mothers ... We have no data on betahistine in milk, but believe it could adversely affect the baby. Luckily, the drug is metabolized very ...
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KEGG DRUG: Betahistine mesilateKEGG DRUG: Betahistine mesilate
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Tinnitus can arise anywhere along the auditory pathway, from the outer ear through the middle and inner ear to the brains auditory cortex, where its thought to be encoded (in a sense, imprinted). One of the most common causes of tinnitus is damage to the hair cells in the cochlea (see "Auditory pathways and tinnitus"). These cells help transform sound waves into nerve signals. If the auditory pathways or circuits in the brain dont receive the signals theyre expecting from the cochlea, the brain in effect "turns up the gain" on those pathways in an effort to detect the signal - in much the same way that you turn up the volume on a car radio when youre trying to find a stations signal. The resulting electrical noise takes the form of tinnitus - a sound that is high-pitched if hearing loss is in the high-frequency range and low-pitched if its in the low-frequency range. This kind of tinnitus resembles phantom limb pain in an amputee - the brain is producing abnormal nerve signals to ...
https://banishtinnitus.net/remington-miracle-tinnitus-cure-tinnitus-cure-coming.html
Betahistine Hydrochloride Handling and StorageBetahistine Hydrochloride Handling and Storage
Betahistine - Handling. How should I handle Betahistine safely?. Betahistine - Storage. How should I store Betahistine ?. ;# ... Betahistine - Additional Information. ​The symptoms of a drug allergy include one or more of the following: *Swollen face/eyes/ ...
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Reduce the olanzapine-induced body weight gain with histamine H1 receptor agonist betahistine in ratsReduce the olanzapine-induced body weight gain with histamine H1 receptor agonist betahistine in rats
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Act Betahistine - Medicine ShoppeAct Betahistine - Medicine Shoppe
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pms-Betahistine | RxHealthMedpms-Betahistine | RxHealthMed
Betahistine is belongs to a group of medications used to treat vertigo associated with Ménières disease. Vertigo is a ... The usual recommended dose of betahistine for adults is 24 mg to 48 mg given in 2 or 3 divided doses (i.e., 12 mg to 24 mg ... Betahistine is belongs to a group of medications used to treat vertigo associated with Ménières disease. Vertigo is a ... Betahistine is used to reduce the number of episodes of vertigo associated with Ménières disease. It is believed to work by ...
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Betahistine | Profiles RNS
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Betahistine | VERTIVIB - Vibcare PharmaBetahistine | VERTIVIB - Vibcare Pharma
Vibcare Pharma is an industry leading provider of Betahistine tablets in India. ... Betahistine is an antivertigo drug first used for treating vertigo assosicated with Ménières disease. It is also commonly used ...
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VertigoSERCHistamineDihydrochloride in the treatment16mgMeniere's DiseaseVestibularTabletReceptorsTherapeuticNauseaDescriptorSymptomsSafelyAdverselyDrugWorksPeopleHydrochlorideSerc16mg without prescriptionAntivertigoEffects of betahistineEfficacyAntipsychotic Induced Weight GainGenericBioavailabilityCinnarizineVestibular disordersCompared to placeboMeniere'sDiureticsInner earEffusionIntranasalHistamineDoseMedicationsReceptorTreatmentSinusIncreasesAcuteEffect
Vertigo14
  • Betahistine is used to treat vertigo (dizzy spells), tinnitus (ringing in the ear), hearing loss, nausea or vomiting associated with Meniere disease or vertigo due to inner ear problem. (kkh.com.sg)
  • Betahistine is used to reduce the number of episodes of vertigo associated with Ménière's disease. (rxhealthmed.ca)
  • Betahistine is an antivertigo drug first used for treating vertigo assosicated with Ménière's disease. (vibcare.co.in)
  • Zevert 12 SR contains Betahistine which is a histamine analogue medicine that is used to treat symptoms of Meniere's syndrome such as dizziness (vertigo), ringing in the ears (tinnitus), loss of hearing and nausea. (365chemists.com)
  • The objective of the study was to assess the effectiveness and safety of oral betahistine in treatment naïve patients with acute peripheral vertigo, administered over 21 days. (ijorl.com)
  • Findings suggest that 48 mg betahistine (16 mg, TID) therapy is effective in treatment naive patients with acute peripheral vertigo. (ijorl.com)
  • Use of Betahistine in the treatment of peripheral vertigo. (ijorl.com)
  • Lacour M, Sterkers O. Histamine and Betahistine in the treatment of vertigo: elucidation of mechanisms of action. (ijorl.com)
  • Effectiveness of Betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The virtuoso study. (ijorl.com)
  • Betahistine dihydrochloride in the treatment of vertigo of peripheral vestibular origin. (ijorl.com)
  • Long-term prophylactic treatment of attacks of vertigo in Meniere's disease-comparison of a high with a low dosage of betahistine in an open trial. (ijorl.com)
  • Benecke H, Garrigues PH, Sidek D, Uloziene I, Sondag E. Effects of Betahistine on Patient-Reported Outcomes in Routine Practice in Patients with Vestibular Vertigo and Appraisal of Tolerability: Experience in the OSVaLD Study. (ijorl.com)
  • Vertigo was attributed to vestibular deficiency and treated with betahistine. (cdc.gov)
  • Betahistine is commonly used to relieve the symptoms associated with Ménière's disease such as dizziness, vertigo, loss of balance and ringing in your ears (tinnitus). (healthnavigator.org.nz)
SERC1
  • Dear InfantRisk Center, A mother receives Betahistine (SERC) 24 mg 1 tablet 2 times a day. (infantrisk.com)
Histamine4
  • Betahistine is diaminoxidase inhibitor - the enzyme inactivating histamine. (us.org)
  • Stabilizing the histamine which is formed in an organism, betahistine has a histamine-like effect. (us.org)
  • It is forbidden to consume Betahistine tablets to people with pheochromocytoma because this drug is an analog of histamine, the reception of which is capable of releasing catecholamines and a severe form of hypertension. (us.org)
  • The increased amount of histamine is released from the histaminergic nerve endings stimulates H1 receptors, thus augmenting the direct agonistic effects of betahistine on these receptors. (365chemists.com)
Dihydrochloride in the treatment1
  • A triple blind, placebo controlled, randomized controlled trial of betahistine dihydrochloride in the treatment of primary tinnitus. (amedeo.com)
16mg2
  • EQUIVERT 16MG TABLET contains Betahistine which belongs to the group of medicines called Antivertigo agents. (netmeds.com)
  • Do not take EQUIVERT 16MG TABLET if you are allergic to Betahistine. (netmeds.com)
Meniere's Disease2
  • Betahistine SR is used for the treatment of meniere's disease. (buy-pharma.md)
  • Comparable efficacy and tolerability between twice daily and three times daily Betahistine for Meniere's disease. (ijorl.com)
Vestibular3
  • Betahistine - a remedy for the medical care of vestibular problems. (us.org)
  • In fact, Betahistine is an inhibitor of the H3 receptors in the nuclei of the vestibular apparatus. (us.org)
  • Betahistine in the treatment of tinnitus in patients with vestibular disorders. (bvsalud.org)
Tablet1
  • Each white-to-almost-white, round, flat-faced, bevelled-edged, scored tablet debossed with '16' on both sides of the score on one side and 'BT' on the other contains 16 mg of betahistine. (rxhealthmed.ca)
Receptors1
  • In addition, betahistine has an antagonistic effect at H3 receptors, and increases the levels of neurotransmitters released from the nerve endings. (365chemists.com)
Therapeutic2
  • Replace of Betahistine is usually possible with differences in cost analogs with a similar therapeutic result and components. (us.org)
  • The therapeutic efficacy of Betahistine can be decreased when used in combination with Chloropyramine. (drugbank.com)
Nausea1
  • The main use of betahistine has at Menyer's disease and similar diseases which are followed by dizziness attacks, a sonitus, a hearing impairment, nausea, vomiting. (us.org)
Descriptor1
  • Betahistine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Symptoms2
  • Betahistine SR treats symptoms of Ménière's disease. (buy-pharma.md)
  • Your doctor may advise you to try betahistine for 6 to 12 months to see if it helps to reduce your symptoms. (healthnavigator.org.nz)
Safely2
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  • How should I dispose of Betahistine safely? (snec.com.sg)
Adversely1
  • Hello again, We have no data on betahistine in milk, but believe it could adversely affect the baby. (infantrisk.com)
Drug1
  • Before the usage, you should study the description of the drug Betahistine accurately. (us.org)
Works1
  • Betahistine SR works by increasing the blood flow around the inner ear. (buy-pharma.md)
People2
  • This graph shows the total number of publications written about "Betahistine" by people in this website by year, and whether "Betahistine" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Betahistine" by people in Profiles. (childrensmercy.org)
Hydrochloride3
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  • We are the manufacturers of Betahistine Hydrochloride I.P 16 mg Tablets, and also deals in third party manufacturing in pharma. (texastherapeutics.in)
  • Voltammetric assay of anti-vertigo drug betahistine hydrochloride in sodium lauryl sulphate. (wjgnet.com)
Serc8
  • To evaluate the bioequivalence of 24 mg betahistine dihydrochloride tablets between the test product (Stei ® ) and the reference product (Serc ® ) in healthy Thai volunteers. (tci-thaijo.org)
  • Serc (Betahistine) may be available under multiple brand names and/or in several different forms. (pocketpills.com)
  • Any specific brand name of Serc (Betahistine) may not be available in all of the forms or approved for all of the conditions discussed here. (pocketpills.com)
  • As well, some forms of Serc (Betahistine) may not be used for all of the conditions discussed here. (pocketpills.com)
  • Your doctor may have suggested Serc (Betahistine) for conditions other than those listed in these drug information articles. (pocketpills.com)
  • If you have not discussed this with your doctor or are not sure why you are taking Serc (Betahistine), speak to your doctor. (pocketpills.com)
  • Do not stop taking Serc (Betahistine) without consulting your doctor. (pocketpills.com)
  • Do not give Serc (Betahistine) to anyone else, even if they have the same symptoms as you do. (pocketpills.com)
16mg without prescription2
  • The clinician should inflate the cuff to 5 medications generic betahistine 16mg overnight delivery a pressure 20 to medicine rock betahistine 16 mg low price 30 mm Hg above systolic pressure medications pictures order betahistine 16 mg overnight delivery, as first identified by palpation of the distal pulse medications 2355 discount betahistine 16mg without prescription. (tatweertech.com)
  • The most helpful signs are goitre buy betahistine 16 mg without a prescription, especially with a bruit audible over it cheap betahistine 16mg without prescription, resting sinus tachycardia or atrial fibrillation discount 16 mg betahistine free shipping, tremor and eye signs generic 16 mg betahistine with mastercard. (bikinglasvegas.com)
Antivertigo2
  • N07CA01 - betahistine : Belongs to the class of antivertigo preparations. (mims.com)
  • He had been taking enteral baclofen, amlodipine, and betahistine dihydrochloride (an antivertigo drug) for 2 months. (medscape.com)
Effects of betahistine2
  • Overall, the results of this study are inconclusive for measuring the beneficial effects of betahistine dihydrochloride on Eustachian tube function. (bu.edu)
  • The increased amount of histamine is released from the histaminergic nerve endings stimulates H1 receptors, thus augmenting the direct agonistic effects of betahistine on these receptors. (netmeds.com)
Efficacy4
  • Though some studies show benefit, there is an absence of high-quality data demonstrating the efficacy of betahistine in the treatment of MD. Despite mixed results from studies in the literature, betahistine treatment remains popular due to a very low-risk profile. (enttoday.org)
  • Definitive large-scale randomized controlled trials with standardized diagnostic criteria, dosing regimens, and long-term follow-ups are required to assess the efficacy of betahistine in MD. (enttoday.org)
  • Betahistine tablets are not recommended for use in children and adolescents below age 18 due to lack of data on safety and efficacy. (pillintrip.com)
  • May reduce the efficacy of betahistine. (medicscientist.com)
Antipsychotic Induced Weight Gain1
  • The study attempts to evaluate a histamine analog long used for the treatment of Meniere's disease, betahistine, that shows promise in reversing the antihistaminergic effects thought to be involved in antipsychotic induced weight gain. (clinicaltrials.gov)
Generic1
  • Modern restorative procedures symptoms kidney buy betahistine 16 mg, especially the use of laminated veneers medications 6 rights generic 16 mg betahistine, can make a significant difference in the quality of the final result treatment 4s syndrome proven 16mg betahistine. (spednet.org)
Bioavailability1
  • Phase 1 trial confirmed superior bioavailability of intranasal betahistine as well as good safety and tolerability Intranasal betahistine program progressing towards proof-of-concept studies in. (globenewswire.com)
Cinnarizine2
  • In addition, like betahistine, cinnarizine has been shown to increase blood flow in compromised intra- and extracranial areas. (medscape.com)
  • Compared with betahistine, the effects of the fixed combination were not only significantly greater but also more rapid in onset, which might be explained by the joint actions of the two compounds within the fixed combination, i.e. the short-term effects of cinnarizine on calcium ion flux in the vestibulum and its long-term effects on cerebral vasculature, and the effects of dimenhydrinate in the brainstem. (medscape.com)
Vestibular disorders1
  • Zamergrad MV , Kunelskaya NL , Guseva AL , Amelin AV , Lilenko SV , Samartcev IN , Zaytseva OV , Melnikov OA , Voronov VA , Lyapin AV . [Betahistine in vestibular disorders: current concepts and perspectives]. (wjgnet.com)
Compared to placebo3
  • A. Patients who have gained a developmentally inappropriate amount of weight on antipsychotics (AP) will see their weight and BMI decrease with betahistine augmentation as compared to placebo augmentation. (clinicaltrials.gov)
  • B. Betahistine augmentation in AP treated patients will increase levels of satiety in a standardized meal situation and decrease caloric intake as compared to placebo augmentation. (clinicaltrials.gov)
  • We searched for randomized controlled trials (RCTs) in the Central Register of Controlled Trials (CENTRAL), Ovid Medline, Ovid Embase, CINAHL, Web of Science, Clinicaltrials.gov, ICTRP, and additional sources for published and unpublished trials, in which betahistine was compared to placebo. (nih.gov)
Meniere's1
  • Betahistine Helps Turkey Oncologist with His Meniere's Symptoms. (waent.org)
Diuretics1
  • Winding during the guidance by betahistine, diuretics, daily dose of tumour has been tried to that clearly why this have concealed, because they refer. (center4family.com)
Inner ear1
  • The antivertiginous effect of betahistine is thought to depend mainly on improvement of microcirculation in the inner ear. (medscape.com)
Effusion1
  • Rarely betahistine sheathed straight effusion. (ecn.cz)
Intranasal1
  • An allergic response was induced in rats followed by one of two betahistine dihydrochloride treatment regimens: drug delivery via transtympanic or intranasal route. (bu.edu)
Histamine2
  • Betahistine dihydrochloride is an orally administered, centrally acting histamine H1 receptor agonist with partial H3 antagonistic activity. (waent.org)
  • The memantine-induced stereotyped sniffing was also attenuated by pretreatment with betahistine (2-[2-(methylamino)ethyl]pyridine), an agent which increases histamine turnover and releases histamine in the brain. (bvsalud.org)
Dose3
  • No serious adverse effects was reported with long-term or high dose administration of betahistine dihydrochloride. (waent.org)
  • Prospective clinical studies with adequate numbers of patients will reveal the efficiency of this metronomic therapy with continuous low-dose betahistine dihydrochloride in treatment of Menière's disease. (waent.org)
  • Although the middle dose of betahistine dihydrochloride (50 mg/mL) delivered transtympanically followed the expected response outcome, the trend did not achieve statistical significance. (bu.edu)
Medications2
  • Purchase 16 mg betahistine mastercard, medications quizzes for nurses. (tatweertech.com)
  • The orthodontic-restorative interaction is discussed in more detail in Chapter 18 medications heart failure cheap 16 mg betahistine. (spednet.org)
Receptor3
  • Betahistine, a partial H1 receptor agonist and potent H3 receptor antagonist, is widely used in Europe and the rest of the world in the treatment of MD. However, lacking FDA approval, it is unavailable in the United States. (enttoday.org)
  • The effectiveness of betahistine dihydrochloride, an H3 receptor blocker, in providing possible relief from middle ear congestion was tested using a rat model. (bu.edu)
  • Betahistine is a weak H 1 receptor agonist and moderate H 3 antagonist . (lucentbiotech.com)
Treatment5
  • Is Betahistine Effective in the Treatment of Ménière's Disease? (enttoday.org)
  • Betahistine dihydrochloride is recommended as first choice medical treatment and in case of failure in medical treatment and if hearing is worth saving, endolymphatic shunt surgery can be employed (2). (waent.org)
  • After 6 months treatment of betahistine dihydrochloride and low-salt diet, the hearing loss was relieved. (waent.org)
  • For the last four years I have started myself a schedule consisting of betahistine dihydrochloride 8 mg/day resembling metronomic therapy which is a well-known practice in cancer treatment. (waent.org)
  • Discount betahistine 16 mg, treatment 002. (bikinglasvegas.com)
Sinus1
Increases1
  • In addition, betahistine has an antagonistic effect at H3 receptors, and increases the levels of neurotransmitters released from the nerve endings. (netmeds.com)
Acute1
  • Betahistine, a vasodilator, is useful in relieving an acute onset of action and are also reported a wound will contract, with linear or punctate pattern without an opinion rather than publishing group from bmj 2006;412:551. (dsaj.org)
Effect2
  • Reassessment of the effect of betahistine for Ménière's disease is now warranted. (nih.gov)
  • Deng C , Lian J, Pai N, Huang X. Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model. (wjgnet.com)
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Meniere Disease (Idiopathic Endolymphatic Hydrops) Treatment & Management: Approach Considerations, Principles of Medical...
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