A subfamily of HERPESVIRIDAE characterized by a relatively long replication cycle. Genera include: CYTOMEGALOVIRUS; MUROMEGALOVIRUS; and ROSEOLOVIRUS.

Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses. (1/28)

Earlier reports (Y. Kawaguchi, R. Bruni, and B. Roizman, J. Virol. 71:1019-1024, 1997; Y. Kawaguchi, C. Van Sant, and B. Roizman, J. Virol. 72:1731-1736, 1998) showed that herpes simplex virus 1 (HSV-1) infection causes the hyperphosphorylation of translation elongation factor 1delta (EF-1delta) and that the modification of EF-1delta is the consequence of direct phosphorylation by a viral protein kinase encoded by the UL13 gene of HSV-1. The UL13 gene is conserved in members of all herpesvirus subfamilies. Here we report the following. (i) In various mammalian cells, accumulation of the hyperphosphorylated form of EF-1delta is observed after infection with alpha-, beta-, and gammaherpesviruses, including HSV-2, feline herpesvirus 1, pseudorabiesvirus, bovine herpesvirus 1, human cytomegalovirus (HCMV), and equine herpesvirus 2. (ii) In human lung fibroblast cells infected with recombinant HSV-1 lacking the UL13 gene, the hypophosphorylated form of EF-1delta is a minor species, whereas the amount of the hyperphosphorylated form of EF-1delta significantly increases in cells infected with the recombinant HSV-1 in which UL13 had been replaced by HCMV UL97, a homologue of UL13. These results indicate that the posttranslational modification of EF-1delta is conserved herpesvirus function and the UL13 homologues may be responsible for the universal modification of the translation factor.  (+info)

Gene content phylogeny of herpesviruses. (2/28)

Clusters of orthologous groups [COGs; Tatusov, R. L., Koonin, E. V. & Lipman, D. J. (1997) Science 278, 631-637] were identified for a set of 13 completely sequenced herpesviruses. Each COG represented a family of gene products conserved across several herpes genomes. These families were defined without using an arbitrary threshold criterion based on sequence similarity. The COG technique was modified so that variable stringency in COG construction was possible. High stringencies identify a core set of highly conserved genes. Varying COG stringency reveals differences in the degree of conservation between functional classes of genes. The COG data were used to construct whole-genome phylogenetic trees based on gene content. These trees agree well with trees based on other methods and are robust when tested by bootstrap analysis. The COG data also were used to construct a reciprocal tree that clustered genes with similar phylogenetic profiles. This clustering may give clues to genes with related functions or with related histories of acquisition and loss during herpesvirus evolution.  (+info)

Betaherpesviruses in transplant recipients. (3/28)

The three betaherpesviruses known to infect humans are cytomegalovirus (CMV) and human herpesviruses 6 and 7 (HHV-6 and -7). All three viruses can infect opportunistically after organ transplantation. CMV causes a variety of end-organ diseases, including pneumonitis, hepatitis and gastrointestinal ulceration. Patients who develop overt CMV disease have significantly higher CMV viral loads than infected patients without evidence of clinical disease. A high CMV viral load largely explains the previously described risk factors for the development of CMV disease, which include donor/recipient serostatus before transplant and viraemia after transplant. CMV also causes some cases of allograft rejection, which can be prevented by antiviral prophylaxis. Application of similar quantitative methods for the study of HHV-6 and -7 have shown that HHV-6 and CMV are significantly and independently associated with biopsy-proven graft rejection after liver transplantation. The full clinicopathological significance of the betaherpesviruses may, thus, be greater than is currently appreciated.  (+info)

Simian homologues of human gamma-2 and betaherpesviruses in mandrill and drill monkeys. (4/28)

Recent serological and molecular surveys of different primate species allowed the characterization of several Kaposi's sarcoma-associated herpesvirus (KSHV) homologues in macaques, African green monkeys, chimpanzees, and gorillas. Identification of these new primate rhadinoviruses revealed the existence of two distinct genogroups, called RV1 and RV2. Using a degenerate consensus primer PCR method for the herpesvirus DNA polymerase gene, the presence of KSHV homologues has been investigated in two semi-free-ranging colonies of eight drill (Mandrillus leucophaeus), five mandrill (Mandrillus sphinx), and two hybrid (Mandrillus leucophaeus-Mandrillus sphinx) monkeys, living in Cameroon and Gabon, Central Africa. This search revealed the existence of not only two distinct KSHV homologues, each one belonging to one of the two rhadinovirus genogroups, but also of two new betaherpesvirus sequences, one being close to cytomegaloviruses and the other being related to human herpesviruses 6 and 7 (HHV-6 and -7). The latter viruses are the first simian HHV-6 and -7 homologues identified to date. These data show that mandrill and drill monkeys are the hosts of at least four novel distinct herpesviruses. Moreover, mandrills, like macaques and African green monkeys, harbor also two distinct gamma-2 herpesviruses, thus strongly suggesting that a second gamma-2 herpesvirus, belonging to the RV2 genogroup, may exist in humans.  (+info)

Detection of bovine herpesvirus 4 (BoHV-4) DNA in the cell fraction of milk of dairy cattle with history of BoHV-4 infection. (5/28)

We have demonstrated, by PCR and restriction enzyme analysis of the PCR product, the presence of bovine herpesvirus 4 (BoHV-4) DNA in the cell fraction of milk from dairy cattle with a history of BoHV-4 infection. We next evaluated the infectious nature of BoHV-4 DNA in those cells. Cocultivation of a BoHV-4-sensitive cell line with BoHV-4 DNA-positive milk cell samples produced cytopathic effects. The same result was obtained from frozen and thawed milk cell fraction coming from the cell milk fraction PCR-positive cows, ensuring that cells were killed and only infectious virus could be recovered after cocultivation with sensitive cells. This report shows that infectious BoHV-4 can be present in milk cells and that therefore nursing may be one of the transmission routes of BoHV-4.  (+info)

Analysis and characterization of the complete genome of tupaia (tree shrew) herpesvirus. (6/28)

The tupaia herpesvirus (THV) was isolated from spontaneously degenerating tissue cultures of malignant lymphoma, lung, and spleen cell cultures of tree shrews (Tupaia spp.). The determination of the complete nucleotide sequence of the THV strain 2 genome resulted in a 195,857-bp-long, linear DNA molecule with a G+C content of 66.5%. The terminal regions of the THV genome and the loci of conserved viral genes were found to be G+C richer. Furthermore, no large repetitive DNA sequences could be identified. This is in agreement with the previous classification of THV as the prototype species of herpesvirus genome group F. The search for potential coding regions resulted in the identification of 158 open reading frames (ORFs) regularly distributed on both DNA strands. Seventy-six out of the 158 ORFs code for proteins that are significantly homologous to known herpesvirus proteins. The highest homologies found were to primate and rodent cytomegaloviruses. Biological properties, protein homologies, the arrangement of conserved viral genes, and phylogenetic analysis revealed that THV is a member of the subfamily Betaherpesvirinae. The evolutionary lineages of THV and the cytomegaloviruses seem to have branched off from a common ancestor. In addition, it was found that the arrangements of conserved genes of THV and murine cytomegalovirus strain Smith, both of which are not able to form genomic isomers, are colinear with two different human cytomegalovirus (HCMV) strain AD169 genomic isomers that differ from each other in the orientation of the long unique region. The biological properties and the high degree of relatedness of THV to the mammalian cytomegaloviruses allow the consideration of THV as a model system for investigation of HCMV pathogenicity.  (+info)

Selective reactivation of human herpesvirus 6 variant a occurs in critically ill immunocompetent hosts. (7/28)

Reactivation of human beta-herpesviruses (cytomegalovirus [CMV], human herpesvirus [HHV]-6, and HHV-7) in nonimmunocompromised hosts is rare. Because these viruses are susceptible to reactivation by cytokines and stress-related mechanisms, the incidence of their reactivation was investigated among 120 patients during stress related to critical illness and compared with findings among 50 healthy volunteers. Human beta-herpesvirus DNA was found in 65% of critically ill patients (60% men; mean age, 63 years) who required admission to an intensive care unit for medical (40%) or surgical (53%) indications or trauma (7%). HHV-6 reactivation was higher in critically ill patients than in healthy volunteers (54/101 vs. 0/50; P=.001). All patients except 1 were confirmed as HHV-6 variant A (mean virus load, 5066 copies/10(6) peripheral blood leukocytes). The reactivation of HHV-6A did not affect disease severity and outcome. No significant reactivation of HHV-7 or CMV was demonstrated among the critically ill patients. These findings contribute to the less-defined epidemiology of HHV-6A infection.  (+info)

Beta-herpesvirus challenges in the transplant recipient. (8/28)

Cytomegalovirus (CMV) has major consequences after allogeneic stem cell and solid organ transplantation. CMV may cause significant morbidity and mortality, and monitoring to detect reactivation to reduce disease or management of end organ disease is associated with increased resource utilization. Two other members of the beta-herpesvirus family, human herpesvirus (HHV) type 6 and HHV-7, are increasingly recognized as important pathogens in transplant recipients, either by direct infection (e.g., encephalitis, hepatitis, or pneumonitis) or via interaction with CMV. In addition to direct effects of CMV infection, such indirect effects as an increased risk for bacterial and fungal infections or impaired graft acceptance and function are important research topics. Diagnosis and treatment of CMV infection is currently more advanced than for HHV-6 and HHV-7.  (+info)

Betaherpesvirinae is a subfamily of herpesviruses, which are a type of double-stranded DNA viruses. This subfamily includes human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7), as well as cytomegalovirus (CMV or HHV-5) in humans, and other species-specific betaherpesviruses in various animals.

These viruses are known to cause a range of clinical manifestations, from mild and self-limiting diseases to severe and life-threatening conditions, depending on the immune status of the host. For instance, primary infection with HHV-6 and HHV-7 typically occurs during early childhood and is usually asymptomatic or associated with a mild febrile illness, while reactivation of these viruses in immunocompromised individuals can lead to more severe complications.

Cytomegalovirus (CMV) infection can cause significant morbidity and mortality in newborns infected in utero, as well as in immunocompromised patients, such as those with HIV/AIDS or transplant recipients. CMV is also a leading cause of congenital hearing loss and developmental disabilities in children.

Betaherpesvirinae viruses are characterized by their ability to establish latency in host cells, where they can remain dormant for extended periods before reactivating under certain conditions, such as immunosuppression or stress. Effective antiviral therapies and vaccines are available for some betaherpesviruses, but there is still no cure for the viral infection, and lifelong latency is common.

... at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Viralzone: Betaherpesvirinae ICTV ( ... Wikimedia Commons has media related to Betaherpesvirinae. Wikispecies has information related to Betaherpesvirinae. "Viral Zone ... Betaherpesvirinae is a subfamily of viruses in the order Herpesvirales and in the family Herpesviridae. Mammals serve as ... Betaherpesvirinae establish latency (site where virus lies dormant until reactivated) in CD34+ myeloid progenitor cells and ...
Cytomegalovirus (CMV) is a member of the betaherpesvirinae subfamily. CMV is responsible for a range of diseases, but mainly ...
Betaherpesvirinae Proboscivirus Elephantid herpesvirus 1 Elephantid betaherpesvirus 1 Ossent, P.; Guscetti, F.; Metzler, A. E ... all of which are classified in the subfamily Gammaherpesvirinae rather than Betaherpesvirinae. These viruses are neither ... of Fatal Elephant Endotheliotrophic Disease Associated with the Expanding Proboscivirus Genus of the Betaherpesvirinae. Proc. ...
However, the genus remains in the Betaherpesvirinae in currently accepted ICTV taxonomy. The genus consists of the following ... Proboscivirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae ... that the phylogenetic divergence of Proboscivirus from other genera in the subfamily Betaherpesvirinae warrants reassignment of ...
... (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family ... Articles with short description, Short description matches Wikidata, Articles with 'species' microformats, Betaherpesvirinae). ...
Within Herpesviridae, HCMV belongs to the Betaherpesvirinae subfamily, which also includes cytomegaloviruses from other mammals ... Betaherpesvirinae, Virus-related cutaneous conditions, Viral diseases). ...
These viruses are of the Herpesviridae family and the Betaherpesvirinae subfamily, under which Cytomegalovirus is also ...
... is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae ...
... in the subfamily Betaherpesvirinae. Rodents serve as natural hosts. There are three species in this genus. Diseases associated ... Betaherpesvirinae, Animal viral diseases, Virus genera, Rodent diseases). ...
... is a genus of viruses in the subfamily Betaherpesvirinae, in the family Herpesviridae, in the order Herpesvirales. ... Betaherpesvirinae". www.ncbi.nlm.nih.gov. Retrieved 2021-06-21. "Taxonomy". talk.ictvonline.org. Retrieved 2021-06-21. v t e ( ... Articles with short description, Short description matches Wikidata, Articles with 'species' microformats, Betaherpesvirinae, ...
HHV-6A and HHV-6B are double-stranded DNA viruses within the Betaherpesvirinae subfamily and of the genus Roseolovirus. HHV-6A ... In this report, the family Herpesviridae was divided into 3 subfamilies (alphaherpesvirinae, betaherpesvirinae and ... Betaherpesvirinae, Viruses articles needing expert attention, Unaccepted virus taxa). ...
Betaherpesvirinae, Immunology, T cells). ...
The study went on to test mice with murine cytomegalovirus, a member of the betaherpesvirinae subfamily, which provided similar ...
... (MleuCMV) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (SaHV-4) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (MuHV-8) is a species of virus in the genus Muromegalovirus, subfamily Betaherpesvirinae, family ...
... (TuHV-1) is a species of virus in the genus Quwivirus in the subfamily Betaherpesvirinae, family ...
... (McHV-9) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family ...
... (MschBHV1) is a species of virus in the genus Quwivirus in the subfamily Betaherpesvirinae, ...
... (McHV-3) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (CeHV-5) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, ...
... (PaHV-4) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (CbHV-1) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (HHV-6B) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family ...
... (MuHV-1) is a species of virus in the genus Muromegalovirus, subfamily Betaherpesvirinae, family ...
... (PaHV-3) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (AoHV-1) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (PnHV-2) is a species of virus in the genus Cytomegalovirus, subfamily Betaherpesvirinae, family ...
... (MuHV-3) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family ...
... (ElHV-4) is a species of virus in the genus Proboscivirus, subfamily Betaherpesvirinae, family ...
Betaherpesvirinae at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Viralzone: Betaherpesvirinae ICTV ( ... Wikimedia Commons has media related to Betaherpesvirinae. Wikispecies has information related to Betaherpesvirinae. "Viral Zone ... Betaherpesvirinae is a subfamily of viruses in the order Herpesvirales and in the family Herpesviridae. Mammals serve as ... Betaherpesvirinae establish latency (site where virus lies dormant until reactivated) in CD34+ myeloid progenitor cells and ...
Betaherpesvirinae. Human cytomegalovirus (HCMV). HCMV inhibits autophagy in human fibroblasts. May activate mTOR pathway?. [71] ... Betaherpesvirinae. 2.2.1. Human Cytomegalovirus (HCMV). HCMV is a widespread opportunistic pathogen that causes severediseases ...
Subfamilia: Betaherpesvirinae Genera: Cytomegalovirus - Muromegalovirus - Roseolovirus - Proboscivirus. Subfamilia: ...
Betaherpesviruses subfamily Betaherpesvirinae *Cytomegaloviruses (CMV) or Human herpesvirus 5 (HHV-5). *Human Herpes Virus 6 ( ...
Categories: Betaherpesvirinae Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted ...
Cells that exhibit cytomegaly also are seen in infections caused by other Betaherpesvirinae. The microscopic description given ...
Categories: Betaherpesvirinae Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted ...
Cells that exhibit cytomegaly also are seen in infections caused by other Betaherpesvirinae. The microscopic description given ...
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. ...
Duplodnaviria / Heunggongvirae / Peploviricota / Herviviricetes / Herpesvirales / Herpesviridae / Betaherpesvirinae / ...
Any of the subfamily Betaherpesvirinae of DNA viruses.. → Definition and anagrams of betaherpesvirus. → Other senses and ...
Betaherpesvirinae, Cytokine, Citoquina, Herpesviridae, Infection, Infección, Mammalia, Rodentia, Vertebrata, Virus, Activité ... Betaherpesvirinae, Cytokine, Citoquina, Herpesviridae, Infection, Infección, Mammalia, Rodentia, Vertebrata, Virus, ...
... in the subfamily Betaherpesvirinae. Humans and monkeys serve as natural hosts. The eight species in this genus include the type ...
IMPORTANCE Human herpesvirus 6A (HHV-6A) is a dsDNA virus belonging to the Roseolovirus genus within the Betaherpesvirinae ...
D3.383.663.283.909.750.374 Betaherpesvirinae B4.909.204.382.150 Betapapillomavirus B4.280.535.100 B4.280.210.655.100 B4.909. ...
D3.383.663.283.909.750.374 Betaherpesvirinae B4.909.204.382.150 Betapapillomavirus B4.280.535.100 B4.280.210.655.100 B4.909. ...
D3.383.663.283.909.750.374 Betaherpesvirinae B4.909.204.382.150 Betapapillomavirus B4.280.535.100 B4.280.210.655.100 B4.909. ...
D3.383.663.283.909.750.374 Betaherpesvirinae B4.909.204.382.150 Betapapillomavirus B4.280.535.100 B4.280.210.655.100 B4.909. ...
D3.383.663.283.909.750.374 Betaherpesvirinae B4.909.204.382.150 Betapapillomavirus B4.280.535.100 B4.280.210.655.100 B4.909. ...
This graph shows the total number of publications written about "Ictalurivirus" by people in this website by year, and whether "Ictalurivirus" was a major or minor topic of these publications ...
A form of PERITONITIS seen in patients with TUBERCULOSIS, characterized by lesion either as a miliary form or as a pelvic mass on the peritoneal surfaces. Most patients have ASCITES, abdominal swelling, ABDOMINAL PAIN, and other systemic symptoms such as FEVER; WEIGHT LOSS; and ANEMIA ...
Betaherpesvirinae [B04.280.382.150] * Gammaherpesvirinae [B04.280.382.400] * Lymphocryptovirus [B04.280.382.400.500] * ...
Disease due to Betaherpesvirinae. Causative agent. False. Family Herpesviridae (organism). Inferred relationship. Some. 1. ... Subfamily Betaherpesvirinae (organism). Is a. True. Family Herpesviridae (organism). Inferred relationship. Some. ...
Duplodnaviria / Heunggongvirae / Peploviricota / Herviviricetes / Herpesvirales / Herpesviridae / Betaherpesvirinae / ...
  • Betaherpesvirinae is a subfamily of viruses in the order Herpesvirales and in the family Herpesviridae. (wikipedia.org)
  • A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. (umassmed.edu)
  • Any of the subfamily Betaherpesvirinae of DNA viruses. (lotsofwords.com)
  • Cytomegalovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. (creative-biolabs.com)
  • Betaherpesvirinae consists of the following five genera: Cytomegalovirus Muromegalovirus Proboscivirus Quwivirus Roseolovirus Viruses in Betaherpesvirinae are enveloped, with icosahedral, spherical to pleomorphic, and Round geometries, and T=16 symmetry. (wikipedia.org)
  • Betaherpesvirinae consists of the following five genera: Cytomegalovirus Muromegalovirus Proboscivirus Quwivirus Roseolovirus Viruses in Betaherpesvirinae are enveloped, with icosahedral, spherical to pleomorphic, and Round geometries, and T=16 symmetry. (wikipedia.org)
  • His work investigates the relationship between Virology and topics such as Caviidae that intersect with problems in Congenital cytomegalovirus infection and Betaherpesvirinae. (research.com)
  • Hay tres subfamilias basadas en sus características biológicas: ALPHAHERPESVIRINAE, BETAHERPESVIRINAE, y GAMMAHERPESVIRINAE. (bvsalud.org)
  • Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae . (4virology.net)