Beta thalassemia. Medical search

A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.

A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.

The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.

A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.

An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia.

Members of the alpha-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 16. They include zeta-globin and alpha-globin. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult HEMOGLOBIN is comprised of 2 alpha-globin chains and 2 beta-globin chains.

Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.

A group of abnormal hemoglobins with similar electrophoretic characteristics. They have faster electrophoretic mobility and different amino acid substitutions in either the alpha or beta chains than normal adult hemoglobin. Some of the variants produce hematologic abnormalities, others result in no clinical disorders.

The great peninsula of southwest Asia comprising most of the present countries of the Middle East. It has been known since the first millennium B.C. In early times it was divided into Arabia Petraea, the northwest part, the only part ever conquered, becoming a Roman province; Arabia Deserta, the northern part between Syria and Mesopotamia; and Arabia Felix, the main part of the peninsula but by some geographers restricted to modern Yemen. (From Webster's New Geographical Dictionary, 1988, p63)

Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.

Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.

An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)

Measurement of hemoglobin concentration in blood.

Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)

A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.

An individual in which both alleles at a given locus are identical.

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.

The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.

ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).

Identification of genetic carriers for a given trait.

Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.

The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.

Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.

Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.

Surgical procedure involving either partial or entire removal of the spleen.

An individual having different alleles at one or more loci regarding a specific character.

Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.

A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.

Pyridine derivatives with one or more keto groups on the ring.

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.

Members of the beta-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 11. They include epsilon-globin, gamma-globin, delta-globin and beta-globin. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult HEMOGLOBIN is comprised of two ALPHA-GLOBIN chains and two beta-globin chains.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in ALPHA-THALASSEMIA.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

The condition of being heterozygous for hemoglobin S.

One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.

An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.

Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.

A hereditary disorder characterized by reduced or absent DELTA-GLOBIN thus effecting the level of HEMOGLOBIN A2, a minor component of adult hemoglobin monitored in the diagnosis of BETA-THALASSEMIA.

An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)

RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.

A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.

The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.

Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.

This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.

A member of the beta-globin family. In humans, delta-globin is encoded in the beta-globin gene cluster located on CHROMOSOME 11. Two delta-globin chains along with two alpha-globin chains form HEMOGLOBIN A2 which makes up about 3% of the HEMOGLOBIN in adults.

Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.

Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.

A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.

The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.

The research and development of ELECTRICAL EQUIPMENT AND SUPPLIES for such medical applications as diagnosis, therapy, research, anesthesia control, cardiac control, and surgery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.

A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.

A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.

One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.

The collective name for the islands of the Pacific Ocean northeast of Australia, including NEW CALEDONIA; VANUATU; New Hebrides, Solomon Islands, Admiralty Islands, Bismarck Archipelago, FIJI, etc. Melanesia (from the Greek melas, black + nesos, island) is so called from the black color of the natives who are generally considered to be descended originally from the Negroid Papuans and the Polynesians or Malays. (From Webster's New Geographical Dictionary, 1988, p748 & Room, Brewer's Dictionary of Names, 1992, p344)

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.

A prospective study on TT virus infection in transfusion-dependent patients with beta-thalassemia. (1/842)

A novel DNA virus designated TT virus (TTV) has been reported to be involved in the development of posttransfusion non-A-C hepatitis. We evaluated the frequency and natural course of TTV infection in a cohort of transfusion-dependent thalassemic patients in a 3-year follow-up study. Ninety-three serum hepatitis C virus (HCV) antibody-negative patients (median age of 8 years; range, 0 to 25) from eight centers were studied. Of them, 34 (37%) had an abnormal alanine-aminotransferase (ALT) baseline pattern, and the other 12 (13%) showed ALT flare-ups during the follow-up. TTV DNA in patient sera collected at the time of enrollment and at the end of follow-up was determined by polymerase chain reaction (PCR). In parallel, serum samples from 100 healthy blood donors were also tested. At baseline, 87 patient sera (93.5%) tested positive for the TTV DNA. Of these TTV DNA-positive patients, 84 (96.5%) remained viremic at the end of the study period. Of the 6 TTV DNA-negative patients, 3 acquired TTV infection during follow-up. However, no definite relation was observed between the results of TTV DNA determination and ALT patterns. TTV viremia was also detectable in 22% of blood donors. In conclusion, TTV infection is frequent and persistent among Italian transfusion-dependent patients. The high rate of viremia observed in healthy donors indicates that the parenteral route is not the only mode of TTV spread. (+info)

Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette. (2/842)

Progress toward gene therapy of beta-chain hemoglobinopathies has been limited in part by poor expression of globin genes in virus vectors. To derive an optimal expression cassette, we systematically analyzed the sequence requirements and relative strengths of the Agamma- and beta-globin promoters, the activities of various erythroid-specific enhancers, and the importance of flanking and intronic sequences. Expression was analyzed by RNase protection after stable plasmid transfection of the murine erythroleukemia cell line, MEL585. Promoter truncation studies showed that the Agamma-globin promoter could be deleted to -159 without affecting expression, while deleting the beta-globin promoter to -127 actually increased expression compared with longer fragments. Expression from the optimal beta-globin gene promoter was consistently higher than that from the optimal Agamma-globin promoter, regardless of the enhancer used. Enhancers tested included a 2.5-kb composite of the beta-globin locus control region (termed a muLCR), a combination of the HS2 and HS3 core elements of the LCR, and the HS-40 core element of the alpha-globin locus. All three enhancers increased expression from the beta-globin gene to roughly the same extent, while the HS-40 element was notably less effective with the Agamma-globin gene. However, the HS-40 element was able to efficiently enhance expression of a Agamma-globin gene linked to the beta-globin promoter. Inclusion of extended 3' sequences from either the beta-globin or the Agamma-globin genes had no significant effect on expression. A 714-bp internal deletion of Agamma-globin intron 2 unexpectedly increased expression more than twofold. With the combination of a -127 beta-globin promoter, an Agamma-globin gene with the internal deletion of intron 2, and a single copy of the HS-40 enhancer, gamma-globin expression averaged 166% of murine alpha-globin mRNA per copy in six pools and 105% in nine clones. When placed in a retrovirus vector, this cassette was also expressed at high levels in MEL585 cells (averaging 75% of murine alpha-globin mRNA per copy) without reducing virus titers. However, recombined provirus or aberrant splicing was observed in 5 of 12 clones, indicating a significant degree of genetic instability. Taken together, these data demonstrate the development of an optimal expression cassette for gamma-globin capable of efficient expression in a retrovirus vector and form the basis for further refinement of vectors containing this cassette. (+info)

Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemia. (3/842)

BACKGROUND AND OBJECTIVE: Patients with thalassemia major and intermedia show a marked variability of serum indirect bilirubin levels. In this paper we tested the hypothesis related to the variability of the glucuronidation bilirubin rate which depends on the configuration of the A(TA)nTAA motif of the UGT1*1 glucuronosyltransferase gene promoter. DESIGN AND METHODS: We studied the configuration of the A(TA)nTAA motif in 26 patients with thalassemia major and 34 with thalassemia intermedia. RESULTS: In patients with thalassemia major and in those with thalassemia intermedia significantly higher bilirubin levels were found in patients with the (TA)7/(TA)7 genotype, than in those with the (TA)7/(TA)6 or (TA)6/(TA)6 genotype. INTERPRETATION AND CONCLUSIONS: These results indicate that the (TA)7/(TA)7 genotype, the configuration found in patients with Gilbert's syndrome, is capable of modifying the clinical phenotype of homozygous beta-thalassemia. This is an example of the role played by co-inherited modifying gene(s) on the extent of clinical heterogeneity of monogenic disorders. (+info)

Busulphan level and early mortality in thalassaemia patients after BMT. (4/842)

The aim of the study was to correlate busulphan (BU) levels of thalassaemia patients with outcome of allogeneic transplant. BU levels were measured by gas chromatography mass fragmentography. All patients received a standardised dose of BU 16 mg/kg, and cyclophosphamide 150 or 200 mg/kg. For area-under-the-curve analysis (AUC), blood samples were obtained at 0, 1, 2, 3, 4 and 6 h after the first and fifth dose for all patients, and additional levels were measured after ninth and/or 13th dose in most patients. Outcome parameters examined included veno-occlusive disease of liver (VOD), idiopathic interstitial pneumonitis, chimerism, and day 90 survival. Twenty consecutive thalassaemia patients who underwent haematopoietic stem cell transplantation were studied. The median age at transplant was 11.2 years (range 3-21 years). Mean BU AUC levels were correlated with age at transplant (r = 0.58, P = 0.007). Nine patients developed VOD and six had mixed chimerism, but these did not correlate with mean BU AUC level. Four patients died before day 50 from VOD and interstitial pneumonitis. Patients with BU AUC levels greater than the median (908 micromol x min/l) had significantly lower probability of survival at day 90 (60%), whereas patients with BU AUC level less than the median all survived beyond day 90. No patient had graft rejection. In conclusion, a high BU AUC level was associated with a higher treatment-related mortality in thalassaemia patients after transplant. (+info)

A complex haemoglobinopathy diagnosis in a family with both beta zero- and alpha (zero/+)-thalassaemia homozygosity. (5/842)

The occurrence of point mutation alpha-thalassaemia and of complex combinations of haemoglobin defects is underestimated. Haemoglobinopathies, the most frequent monogenic recessive autosomal disorder in man, occur predominantly in Mediterranean, African and Asiatic populations. However, countries of immigration with a low incidence in the indigenous population, are now confronted with a highly heterogeneous array of imported defects. Furthermore, the occurrence of severe phenotypes is bound to increase in the near future because of the endogamous growth of the ethnical minorities and the lack of prevention. We describe an Afghan family in which both partners of a consanguineous relationship are carriers of a beta- as well as an alpha-thalassaemia determinant. The combination of defects was revealed by the in vitro measurement of the beta/alpha biosynthetic ratio and was characterised at the DNA level. The molecular defects involved are the Cd5(-CT), a Mediterranean beta zero-thalassaemia mutation, and the alpha 2(zero/+)-thalassaemia AATA(-AA) polyadenylation defect. The alpha-thalassemia defect is a rare RNA-processing mutant described only twice before in heterozygous form in Asian-Indian patients. The mutation suppresses the expression of a alpha 2 gene and reduces the expression of the less efficient, 3' located alpha 1 gene as well, inducing a near alpha zero-thalassaemia phenotype. This defect is now described for the first time in the homozygous condition in one of the children who, in addition to being homozygous for the alpha-thalassaemia point mutation, is also a carrier of the beta zero-thalassaemia defect. A previously described homozygous case of the alpha (zero/+)-thalassaemia condition, caused by a similar polyadenylation defect, was characterised by a severe HbH disease. However, the patient described here present at 7 years of age with severe caries, like his beta-thalassaemia homozygous brother but without hepatosplenomegaly, haemolysis or severe anaemia. The haematological analysis revealed 9.5 g/dl Hb; 5.4 x 10(12)/I RBC; 0.33 I/I PCV; 61 fl MCV; 17.6 pg MCH and 6.2% of HbA2. The biosynthetic ratio beta:alpha was 1.6 and no HbH fraction was detectable either on electrophoresis or as inclusion bodies. The parents reported no complications during pregnancy, at birth, or in the neonatal period in rural Afghanistan. We presume therefore that the counterbalancing effect induced by the co-existing beta-thalassaemia defect could have modified a potentially severe perinatal HbH disease into a strongly hypochromic but well compensated 'alpha zero-like heterozygous' thalassaemia phenotype. The risk of a severe HbH disease, could have been easily missed in this family which was referred because of a child affected with beta-thalassaemia major. (+info)

Impairment of Plasmodium falciparum growth in thalassemic red blood cells: further evidence by using biotin labeling and flow cytometry. (6/842)

Certain red blood cell (RBC) disorders, including thalassemia, have been associated with an innate protection against malaria infection. However, many in vitro correlative studies have been inconclusive. To better understand the relationship between human RBCs with thalassemia hemoglobinopathies and susceptibility to in vitro infection, we used an in vitro coculture system that involved biotin labeling and flow cytometry to study the ability of normal and variant RBC populations in supporting the growth of Plasmodium falciparum malaria parasites. Results showed that both normal and thalassemic RBCs were susceptible to P falciparum invasion, but the parasite multiplication rates were significantly reduced in the thalassemic RBC populations. The growth inhibition was especially marked in RBCs from alpha-thalassemia patients (both alpha-thalassemia1/alpha-thalassemia2 and alpha-thalassemia1 heterozygote). Our observations support the contention that thalassemia confers protection against malaria and may explain why it is more prevalent in malaria endemic areas. (+info)

Immunological analysis of beta-thalassemic mouse intestinal proteins reveals up-regulation of sucrase-isomaltase in response to iron overload. (7/842)

Maintenance of iron homeostasis must balance the demand for iron due to heme synthesis, which is driven by hematopoiesis, and the restricted intestinal uptake of iron, which otherwise limits absorption of this toxic element. The consequences of perturbed iron homeostasis are witnessed in inherited forms of beta-thalassemia in which erythroid hyperplasia results in enhanced intestinal iron absorption despite tissue iron overload. To gain a better understanding of intestinal factors that are induced when iron homeostasis is disrupted, a panel of monoclonal antibodies that recognize intestinal microvillous membrane proteins of the beta-thalassemic Hbbd(th3)/Hbbd(th3) mouse was established. The monoclonal antibodies were screened by differential Western blotting against normal and beta-thalassemic mouse intestine to identify antigens modulated in the disease state. Here we report the initial characterization of one immunoreactive species that is up-regulated in beta-thalassemic mouse intestine and the tentative identification of this antigen as sucrase-isomaltase. Studies in Caco-2 cells revealed the rather unexpected finding that expression of this intestinal hydrolase is increased in response to iron toxicity. (+info)

Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation. (8/842)

A 13-year-old patient with transfusion-dependent beta thalassemia major developed acute regimen-related lung toxicity after the conditioning regimen but before allogeneic bone marrow transplantation. He was successfully managed on non-invasive ventilatory support. Advances in non-invasive ventilatory support may drastically improve the outlook of this subset of patients who otherwise have a grim prognosis. (+info)

... beta thalassemia major, a form of microcytic anemia. In β thalassemia major the beta hemoglobin chain is completely absent, ... Galanello, Renzo; Origa, Raffaella (2010-05-21). "Beta-thalassemia". Orphanet Journal of Rare Diseases. 5: 11. doi:10.1186/1750 ...

https://en.wikipedia.org/wiki/Anisopoikilocytosis

"Beta thalassemia". Genetics Home Reference. U.S. National Library of Medicine, NIH. March 13, 2011. Retrieved 21 March 2011. ... "Hemoglobinopathies and Thalassemias". Archived from the original on 2007-12-15. Retrieved 2011-03-03. "Sickle Cell Trait and ... Rivella, S. (May 2009). "Ineffective erythropoiesis and thalassemias". Curr. Opin. Hematol. 16 (3): 187-94. doi:10.1097/MOH. ... "Alpha thalassemia". Genetics Home Reference. U.S. National Library of Medicine. February 27, 2011. Retrieved 3 March 2011. " ...

https://en.wikipedia.org/wiki/List_of_hematologic_conditions

Beta-thalassemia major is an inherited blood disease in which beta haemoglobin is missing and patients are dependent on regular ... "Five year outcome of lentiviral gene therapy for human beta-thalassemia, lessons and prospects". Thalassemia Reports. 3 (1s): ... In September it was announced that an 18-year-old male patient in France with beta-thalassemia major had been successfully ... In May, the EMA approved betibeglogene autotemcel (Zynteglo) for treating beta thalassemia for people twelve years of age and ...

https://en.wikipedia.org/wiki/Gene_therapy

Rund D, Rachmilewitz E (September 2005). "Beta-thalassemia". The New England Journal of Medicine. 353 (11): 1135-46. doi: ... August 1998). "Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major". The New ... progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia ... double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major ...

https://en.wikipedia.org/wiki/Gideon_Koren

Beta thalassemia is caused by mutations to or deletions of the HBB gene leading to reduced or absent synthesis of the beta ... Betibeglogene autotemcel, sold under the brand name Zynteglo, is a medication for the treatment for beta thalassemia, a rare ... In early clinical trials several patients with beta thalassemia, who usually require frequent blood transfusions to treat their ... "Lentiviral vectors". Monday, 8 July 2019 Cao, Antonio; Galanello, Renzo (21 January 2010). "Beta-thalassemia". Genetics in ...

https://en.wikipedia.org/wiki/Betibeglogene_autotemcel

"Beta-thalassemia". Orphanet Journal of Rare Diseases. 5: 11. doi:10.1186/1750-1172-5-11. ISSN 1750-1172. PMC 2893117. PMID ...

https://en.wikipedia.org/wiki/Gene_testing

Diamond was researching the Beta Thalassemia genetic trait, which he suspected was present in Ashkenazi Jewish families in his ... Diamond, Stanley M. (3 August 2004). "About the beta-thalassemia project". DiamondGen. Retrieved 14 March 2016. Burstein, ...

https://en.wikipedia.org/wiki/JRI-Poland

HBA2 Thalassemia, Hispanic gamma-delta-beta; 604131; LCRB Thalassemia-beta, dominant inclusion-body; 603902; HBB Thalassemias, ... alpha-; 604131; HBA1 Thalassemias, beta-; 604131; HBB Thanatophoric dysplasia, type I; 187600; FGFR3 Thiamine-responsive ... CYCS Thrombocytopenia with beta-thalassemia, X-linked; 314050; GATA1 Thrombocytopenia, congenital amegakaryocytic; 604498; MPL ... ACAT1 Alpha-thalassemia myelodysplasia syndrome, somatic; 300448; ATRX Alpha-thalassemia mental retardation syndrome; 301040; ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

These disorders include sickle cell-beta thalassemia. In the case of sickle cell anemia, an individual with one allele for ... 1988). "Clinical and genetic heterogeneity in black patients with homozygous beta-thalassemia from the southeastern United ... Ohno, Kousaku & Suzuki, Kunihiko (1988-12-05). "Multiple Abnormal beta-Hexosaminidase alpha-Chain mRNAs in a Compound- ... sickle cell disorders result from inheritance of the sickle cell gene in a compound heterozygous manner with other mutant beta ...

https://en.wikipedia.org/wiki/Compound_heterozygosity

1988). "Beta-thalassemia due to a T----A mutation within the ATA box". Biochem. Biophys. Res. Commun. 153 (2): 741-7. doi: ... Chang JC, Kan YW (1979). "beta 0 thalassemia, a nonsense mutation in man". Proc. Natl. Acad. Sci. U.S.A. 76 (6): 2886-9. doi: ... The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon - gamma- ... Tuan D, Solomon W, Li Q, London IM (1985). "The "beta-like-globin" gene domain in human erythroid cells". Proc. Natl. Acad. Sci ...

https://en.wikipedia.org/wiki/HBE1

Chang JC, Kan YW (June 1979). "beta 0 thalassemia, a nonsense mutation in man". Proceedings of the National Academy of Sciences ... SNPs pinpoint differences in our susceptibility to a wide range of diseases (e.g. sickle-cell anemia, β-thalassemia and cystic ...

https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism

Beta thalassemia may also result in transfusion dependence. Concerns from repeated blood transfusions include iron overload. ... and beta-thalassemia HbE syndrome HbC syndrome Various other unstable hemoglobin diseases Sideroblastic defect Hereditary ... Causes of decreased production include iron deficiency, vitamin B12 deficiency, thalassemia, and a number of neoplasms of the ... Mentzer WC (April 1973). "Differentiation of iron deficiency from thalassaemia trait". Lancet. 1 (7808): 882. doi:10.1016/s0140 ...

https://en.wikipedia.org/wiki/Anemia

Chang JC, Kan YW (1979). "beta 0 thalassemia, a nonsense mutation in man". Proc. Natl. Acad. Sci. U.S.A. 76 (6): 2886-9. doi: ... Also, in cases of beta-thalassemia and related conditions, gamma chain production may be maintained, possibly as a mechanism to ... 1993). "Normal delta-globin gene sequences in Sardinian nondeletional delta beta-thalassemia". Hemoglobin. 16 (6): 503-9. doi: ... The order of the genes in the beta-globin cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. GRCh38: Ensembl ...

https://en.wikipedia.org/wiki/HBG1

Beta thalassaemia (β-globin). *Hurler syndrome. *Dravet Syndrome. Ataluren (previously PTC124) is a pharmaceutical drug that ... Some genetic disorders, such as thalassemia and DMD, result from point-nonsense mutations. ...

https://en.wikipedia.org/wiki/Nonsense_mutation

Hb H usually occurs in some alpha thalassemia and is composed of four beta globin (protein) chains. This variant is usually ... Another way that beta genes can be inherited is in a homozygous fashion. This means that the person has two abnormal beta genes ... The levels can be normal to increased in beta thalassemia. Hemoglobin F frequently increases in individuals with sickle cell ... This means that the person has one normal beta gene and one abnormal beta gene. This person is considered to be a carrier of ...

https://en.wikipedia.org/wiki/Hemoglobin_variants

... and the abnormal alpha/beta globin chain abnormality of thalassemia from thalassemia mRNA. As a first approach for developing a ... Gilbert, J.M.; Thornton, A.G.; Nienhuis, A.W.; Anderson, W.F.: Cell-free hemoglobin synthesis in beta-thalassemia. Proc. Natl. ... Nienhuis, A.W. and Anderson, W.F.: Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, ... Stripped rabbit reticulocyte ribosomes were programmed with mRNA isolated from thalassemia, sickle cell anemia, or normal human ...

https://en.wikipedia.org/wiki/William_French_Anderson

Application to prenatal diagnosis of beta 0 thalassemia in Sardinia". The New England Journal of Medicine. 302 (4): 185-8. doi: ... ISBN 978-0-12-369428-7. Kan YW, Lee KY, Furbetta M, Angius A, Cao A (January 1980). "Polymorphism of DNA sequence in the beta- ... suggested a prenatal genetic test for Thalassemia that did not rely upon DNA sequencing-then in its infancy-but on restriction ... In 2012, molecular diagnostic techniques for Thalassemia use genetic hybridization tests to identify the specific single ...

https://en.wikipedia.org/wiki/Molecular_diagnostics

"Rheological properties of erythrocytes in heterozygous and homozygous beta thalassaemia". British Journal of Haematology. 43 (3 ...

https://en.wikipedia.org/wiki/Nunera

1 in 25,000 Hb S/Beta-Thalassemia (Hb S/Th) > 1 in 50,000 Inborn errors of amino acid metabolism Tyrosinemia I (TYR I) < 1 in ... 1 in 100,000 Beta-ketothiolase deficiency (BKT) < 1 in 100,000 Propionic acidemia (PROP) > 1 in 75,000 Multiple-CoA carboxylase ... Beta-methyl crotonyl carboxylase deficiency Adenosylcobalamin synthesis defects Inborn errors of fatty acid metabolism Medium/ ...

https://en.wikipedia.org/wiki/List_of_disorders_included_in_newborn_screening_programs

Beta-thalassemia constitutes a major public health problem in the UAE. During 1989-2004, more than 850 patients have been ... in 2014 16,247 people were tested, 342 were Beta-thalassaemia carriers, 8 had sickle-cell anaemia, 205 were sickle-cell anaemia ... Surveys have shown that the UAE exhibits one of the highest carrier frequencies of β-thalassemia in the Persian Gulf region ... thalassaemia, and syphilis. The Health Authority - Abu Dhabi introduced premarital screening and counselling in 2011. 56,226 ...

https://en.wikipedia.org/wiki/Health_in_the_United_Arab_Emirates

Beta-thalassemia. Reduced synthesis of the hemoglobin-beta chain; microcytic hypochromic anemia[18]. Factor II. Venous ... "Beta-thalassemia". Orphanet Journal of Rare Diseases. 5: 11. doi:10.1186/1750-1172-5-11. ISSN 1750-1172. PMC 2893117. PMID ...

https://en.m.wikipedia.org/wiki/Genetic_testing

Antonarakis SE, Irkin SH, Cheng TC, Scott AF, Sexton JP, Trusko SP, Charache S, Kazazian HH (1984). "beta-Thalassemia in ... "Beta-thalassemia due to a T----A mutation within the ATA box". Biochemical and Biophysical Research Communications. 153 (2): ... Zienolddiny S, Ryberg D, Maggini V, Skaug V, Canzian F, Haugen A (April 2004). "Polymorphisms of the interleukin-1 beta gene ... Some diseases that can be caused due to this insufficiency by specific gene transcription are: Thalassemia, lung cancer, ...

https://en.wikipedia.org/wiki/TATA_box

Tadmouri, GO; Gulen, RI (November 2003). "Deniz: the electronic database for beta-thalassemia mutations in the Arab world". ... Some of the diseases are beta-thalassemia mutations, sickle-cell disease, congenital heart-disease, glucose-6-phosphate ... beta thalassemia in all countries, g6dh deficiency all countries. Most genetic markers of Arabs' genetic diseases are ... Some 906 pathologies are endemic to the Arab states, including thalassaemia, Tourette's syndrome, Wilson's disease, Charcot- ...

https://en.wikipedia.org/wiki/Genetic_studies_on_Arabs

In 2010 she performed gene therapy on a child with beta thalassemia. Children who are born with Thalassemia Major often develop ... "Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia". New England Journal of Medicine. 378 (16): 1479-1493. doi: ... "Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia". Nature. 467 (7313): 318-322. Bibcode ...

https://en.wikipedia.org/wiki/Marina_Cavazzana

Beta-thalassemia is a genetic disease mostly caused by beta-globin gene mutations. Clinical diagnosis is based on ... thalassemia major (TM), thalassemia intermedia (TI) and thalassemia minor (TI). Another classification was established in 2012 ... Patients with beta thalassemia major are more affected and are recommended to receive transfusion throughout their lives. ... Therefore, other than diagnosing anemias that require transfusion, diagnosis for the two main causes (beta-thalassemia and ...

https://en.wikipedia.org/wiki/Transfusion-dependent_anemia

Olivieri NF, Pakbaz Z, Vichinsky E (2011). "Hb E/beta-thalassaemia: a common & clinically diverse disorder". Indian J. Med. Res ... There is a variety of phenotypes depending on the interaction of HbE and α-thalassemia. The presence of the α-thalassemia ... Hemoglobin E/β-thalassemia is a severe disease, and it still has no universal cure. It affects more than a million people in ... The reduced synthesis of β chain may cause β-thalassemia. Also, this hemoglobin variant has a weak union between α- and β- ...

https://en.wikipedia.org/wiki/Hemoglobin_E

2010) on Beta Thalassemia Heterogeneity in Lebanon found out that the thalassemia mutations in Lebanese Christians are similar ... "Genetic heterogeneity of Beta thalassemia in Lebanon reflects historic and recent population migration." Annals of human ...

https://en.wikipedia.org/wiki/Antiochian_Greek_Christians

2006). "Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia". Ann. N. Y. Acad. Sci. 1054 ... 2004). "Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia". ... 2004). "Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state". J. Biol. Chem. 279 ( ...

https://en.wikipedia.org/wiki/ERAF

Extended red blood cell phenotyping is also recommended for people with beta-thalassemia. Blood group systems other than ABO ...

https://en.wikipedia.org/wiki/Blood_compatibility_testing

... he was the first to discover a point-mutation causing human beta-thalassemia; with Golbus' help, he was the first to carry out ... Kan was the first to discover the gene deletion in human alpha-thalassemia; ... prenatal diagnosis (for a haemoglobinopathy). Kan is best known for his groundbreaking works in sickle cell and thalassemia. He ...

https://en.wikipedia.org/wiki/Yuet_Wai_Kan

It was the first SOD whose atomic-detail crystal structure was solved, in 1975.[8] It is an 8-stranded "Greek key" beta-barrel ... Overexpression of SOD1 has been linked to the neural disorders seen in Down syndrome.[38] In patients with thalassemia, SOD ... "Status of Superoxide Dismutase in Transfusion Dependent Thalassaemia". North American Journal of Medical Sciences. 7 (5): 194- ...

https://en.wikipedia.org/wiki/Orgotein

TGF beta receptors: Endoglin/Alk-1/SMAD4 (Hereditary hemorrhagic telangiectasia). *TGFBR1/TGFBR2 (Loeys-Dietz syndrome) ... Alpha-thalassemia mental retardation syndrome. *Siderius X-linked mental retardation syndrome. *Eye disorders: Color blindness ...

https://en.wikipedia.org/wiki/Kallmann_syndrome

beta-ketothiolase deficiency. *beta thalassemia. *bladder cancer. *breast cancer. *carnitine palmitoyltransferase I deficiency ...

https://tl.wikipedia.org/wiki/Kromosomang_11_

Presumably penicillin G could be given with a beta-lactamase inhibitor combination, such as Unasyn, for patients with a beta- ... Individuals with β-thalassemia and smokers are also listed as high-risk. These individuals, like asplenics and alcoholics, have ... Antibiotics that contain beta-lactamase inhibitors (i.e., oral Augmentin or parenteral Unasyn) cover C. canimorsus as well as ... After diagnosis, provided the strain is not beta-lactamase producing, medication should be switched to penicilin G. ...

https://en.wikipedia.org/wiki/Capnocytophaga_canimorsus

However, the level of Hb F can be elevated in persons with sickle-cell disease and beta-thalassemia. ... "Hemoglobinopathies and Thalassemias". Retrieved 2007-12-26.. *^ Reed, Leslie. "Adaptation found in mouse genes." Omaha World- ... Some mutations in the globin chain are associated with the hemoglobinopathies, such as sickle-cell disease and thalassemia. ... A (mostly) separate set of diseases called thalassemias involves underproduction of normal and sometimes abnormal hemoglobins, ...

https://en.wikipedia.org/wiki/Hemoglobin_deficiency

... beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, phosphate depletion, iron deficiency and Wilson's disease. ... Thalassemia is a genetic disease that results in the production of an abnormal ratio of hemoglobin subunits. ... Both sickle-cell disease and thalassemia are more common in malaria areas, because these mutations convey some protection ...

https://en.m.wikipedia.org/wiki/Red_blood_cells

Beta-thalassemia (due to expansion of bone marrow secondary to increased hematopoiesis)[5] ...

https://simple.wikipedia.org/wiki/Skull_bossing

"Mutations in the beta propeller WDR72 cause autosomal-recessive hypomaturation amelogenesis imperfecta". Am. J. Hum. Genet. 85 ... Alpha-thalassemia mental retardation syndrome. *Siderius X-linked mental retardation syndrome. *Eye disorders: Color blindness ...

https://en.wikipedia.org/wiki/Amelogenesis_imperfecta

Livingstone FB (1985). Frequencies of hemoglobin variants: thalassemia, the glucose-6-phosphate dehydrogenase deficiency, G6PD ... as well as interfering with beta oxidation, an important part of valproate metabolism), and other NSAIDs. Corticosteroids may ...

https://en.wikipedia.org/wiki/Acetylsalicylic_acid

Beta-thalassemia minor) অথবা বিটা থ্যালাসেমিয়া ট্রেইট (Beta-thalassemia trait). ... hemoglobinopathy: Thalassemia (alpha, beta, delta) · Sickle-cell disease/trait · HPFH membrane: Hereditary spherocytosis( ... দুটি জিন ত্রুটিপূর্ণ হলে মাঝারি থেকে মারাত্মক উপসর্গ দেখা যায়। এ অবস্থাকে বলে বিটা থ্যালাসেমিয়া মেজর ( Beta-thalassemia major ... থ্যালাসেমিয়া (ইংরেজি: Thalassemia) একটি অটোজোমাল মিউট্যান্ট প্রচ্ছন্ন জিনঘটিত বংশগত রক্তের রোগ। এই রোগে রক্তে অক্সিজেন ...

https://bn.wikipedia.org/wiki/থ্যালাসেমিয়া

Alpha-thalassemia mental retardation syndrome. *Siderius X-linked mental retardation syndrome. *Eye disorders: Color blindness ...

https://en.wikipedia.org/wiki/Diabetes_insipidus

Ang mga ito ay kinabibilangan ng sakit na sickle-haemoglobin C (HbSC), sickle beta-plus-thalassaemia (HbS/β+) at sickle beta- ... general considerations and impact on patients with sickle-cell disease and thalassemia and on blood transfusions". FEMS ...

https://tl.wikipedia.org/wiki/Sakit_na_sickle-cell

... as well as in beta-thalassemia and hemochromatosis.[2] References[edit]. *^ Rooks J, Ory H, Ishak K, Strauss L, Greenspan J, ...

https://en.wikipedia.org/wiki/Hepatocellular_adenoma

R216W: characterized by a beta thalassemia-type disease, i.e. microcytic anemia, absence of hemoglobin B, and hereditary ... beta thalassemia; mild thrombocytopenia with features of the gray platelet syndrome. ... Molete JM, Petrykowska H, Sigg M, Miller W, Hardison R (Jan 2002). "Functional and binding studies of HS3.2 of the beta-globin ... a thalassemia-like disorder due to unbalanced hemoglobin production, and/or a porphyria-like disorder.[40][37] A recent study ...

https://en.wikipedia.org/wiki/GATA1

... ß-thalassemia in a patient. "Intergenic" refers to long non-coding RNAs that are transcribed from non-coding DNA sequences ... "Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". ...

https://en.wikipedia.org/wiki/Long_non-coding_RNA

Beta-thalassemia major anemia. *Beta-thalassemia (gene promoter involvement). *Bethlem myopathy. Bh[edit]. *Bhaskar Jagannathan ...

https://en.wikipedia.org/wiki/List_of_diseases_

hemoglobinopathy: Thalassemia *alpha. *beta. *delta. *Sickle-cell disease/trait. *HPFH. *membrane: Hereditary spherocytosis * ...

https://en.wikipedia.org/wiki/Megaloblastic_anemia

Beta thalassemia[33]. *Rubinstein-Taybi syndrome[34]. Constitutive vs regulated[edit]. Some promoters are called constitutive ... Kulozik, A. B. K.; Bellan-Koch, A.; Bail, S.; Kohne, E.; Kleihauer, E. (May 1991). "Thalassemia intermedia: moderate reduction ... of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element". Blood. 77 (9): 2054- ...

https://en.wikipedia.org/wiki/Promoter_

Beta-Thalassemia. *Familial Mediterranean fever. *Glucose-6-phosphate dehydrogenase deficiency and Gilbert's Syndrome ...

https://en.wikipedia.org/wiki/Sephardi_Jews

Beta thalassemia may also result in transfusion dependence.[60][61] Concerns from repeated blood transfusions include iron ... Mentzer WC (April 1973). "Differentiation of iron deficiency from thalassaemia trait". Lancet. 1 (7808): 882. PMID 4123424.. ... Thalassemias, causing deficient globin synthesis[17]. *Congenital dyserythropoietic anemias, causing ineffective erythropoiesis ... found in thalassemia major) or leg ulcers (seen in sickle-cell disease). In severe anemia, there may be signs of a hyperdynamic ...

https://en.m.wikipedia.org/wiki/Anaemia

Second, the breast-milk of some women contains a metabolite of progesterone called 3-alpha-20-beta pregnanediol. This substance ... Alpha-thalassemia, e.g. HbH disease. Extrinsic causes of hemolysis[edit]. *Systemic conditions *Sepsis ... "Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3(alpha), 20(beta)- ...

https://en.wikipedia.org/wiki/Neonatal_jaundice

"Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal ... Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L (December 1998). "Interleukin-10 and transforming growth factor-beta ...

https://en.m.wikipedia.org/wiki/Promoter_

Beta normal form -- Beta prime distribution -- Beta rectangular distribution -- Beta skeleton -- Beta thalassemia -- Beta ... Beta distribution -- Beta-dual space -- Beta function -- Beta integral -- Beta integral (disambiguation) -- Beta negative ...

https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Mathematics/List_of_mathematics_articles_

Alpha-thalassemia mental retardation syndrome. *Siderius X-linked mental retardation syndrome. *Eye disorders: Color blindness ...

https://en.wikipedia.org/wiki/Ocular_albinism

... a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait. „Blood". ...

https://pl.wikipedia.org/wiki/Medycyna_ewolucyjna

hemoglobinopathy: Thalassemia (alpha, beta, delta) · Sickle-cell disease/trait · HPFH membrane: Hereditary spherocytosis( ...

https://bn.wikipedia.org/wiki/রক্তশূন্যতা

... thalassemia. Iron is actually excreted in urine[22] and is also concentrated in bile[23] which is excreted in feces.[24] ... Beta amyloid Cadmium[57][58] Metallothionein. Thiolate proteins Molybdenum[59]. Nitrate reductase. Sulfite oxidase. Xanthine ...

https://en.wikipedia.org/wiki/Metalloprotein

... is a blood disorder in which the body has a problem producing beta globin, a component of hemoglobin, the ... About Beta Thalassemia. Beta thalassemia happens when the gene that controls the production of beta globin is defective. Beta ... Types of Beta Thalassemia. There are three types of beta thalassemia, depending upon whether one or two beta globin genes are ... Beta thalassemia minor, or beta thalassemia trait, happens when one of the beta globin genes is mutated. People with this ...

http://kidshealth.org/Nemours/en/parents/beta-thalassemia.html

Beta thalassemia is a blood disorder that reduces the production of hemoglobin. Explore symptoms, inheritance, genetics of this ... The absence of beta-globin is referred to as beta-zero (β0) thalassemia. Other HBB gene mutations allow some beta-globin to be ... A reduced amount of beta-globin is called beta-plus (β+) thalassemia. Having either β0 or β+ thalassemia does not necessarily ... Beta thalassemia is a fairly common blood disorder worldwide. Thousands of infants with beta thalassemia are born each year. ...

https://medlineplus.gov/genetics/condition/beta-thalassemia/

Blood transfusions are part of the treatment routine for some people with a blood disorder called beta thalassemia. Learn when ... Blood Transfusions for Beta Thalassemia. Blood transfusions could be a regular thing if you or your child has a blood disorder ... Beta thalassemia lowers your hemoglobin -- a protein that helps red blood cells carry oxygen to your organs and tissues -- and ... The type of beta thalassemia you or your child has will help your doctor decide if you need blood transfusions. ...

https://www.webmd.com/a-to-z-guides/beta-thal-19/beta-thalassemia-blood-transfusions

Beta thalassemia trait (also known as beta thalassemia minor) involves heterozygous inheritance of a beta-thalassemia mutation ... Beta thalassemia minor can also present as beta thalassemia silent carriers; those who inherit a beta thalassemic mutation but ... Beta thalassemias (β thalassemias) are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or ... Alpha-thalassemia Anisopoikilocytosis (variance in red blood cell size, usually as a result of beta thalassemia) "Beta ...

https://en.wikipedia.org/wiki/Beta_thalassemia

Learn about symptoms, treatment, who is a carrier, and diagnosis for beta thalassemia. ... Beta thalassemia is a group of genetic blood disorders that share in common the defective production of hemoglobin, similar to ... Thalassemia patients make defective hemoglobin.. *There are two forms of beta thalassemia: thalassemia minor and thalassemia ... Beta Thalassemia - Share Your Experience Do you or a relative have beta thalassemia? Please tell us about your experience. ...

https://www.medicinenet.com/beta_thalassemia/article.htm

There are two main types of thalassemia: alpha and beta. Thalassemia can cause mild or severe anemia. ... Thalassemia is an inherited blood disorder that is passed down through the parents genes. ... Beta Thalassemia. Facebook Twitter Linkedin Pinterest Print. What is beta thalassemia?. Thalassemia (thal-uh-SEE-mee-uh) is a ... What are the complications of beta thalassemia?. Complications of beta thalassemia vary depending on the type:. * Thalassemia ...

https://www.hopkinsmedicine.org/health/conditions-and-diseases/beta-thalassemia

Cell-Free Hemoglobin Synthesis in Beta-Thalassemia. J. M. Gilbert, A. G. Thornton, A. W. Nienhuis, and W. F. Anderson ... Induction of β-Globin Synthesis in the β-Thalassaemia of Ferrara. FRANCESCO CONCONI, PETER T. ROWLEY, LAURA DEL SENNO, SANDRO ... Initiation of Globin Synthesis in β-Thalassemia. Ronald G. Crystal, Norton A. Elson, Arthur Nienhuis, Abigail C. Thornton, W. ... Decreased α Globin Messenger RNA Activity associated with Polyribosomes in α Thalassaemia ...

https://www.pnas.org/content/67/4/1854/tab-article-info

... disease Sickle cell-beta thalassemia is caused by inheritance of a sickle cell allele from one parent and a beta thalassemia ... Sickle cell-beta thalassemia is an inherited blood disorder. The disease may range in severity from being relatively benign and ... "Newborn Screening Program - Sickle Cell Beta Thalassemia Disease". www.idph.state.il.us. Retrieved 2015-06-18. CS1 maint: ... Patients with sickle cell-beta thalassemia may present with painful crises similar to patients with sickle cell ...

https://en.wikipedia.org/wiki/Sickle_cell-beta_thalassemia

Intracranial extramedullary hematopoiesis in beta-thalassemia. Korean J Radiol. 2012;13:240.CrossRefPubMedPubMedCentralGoogle ... Origa R. Beta-thalassemia. GeneReviews(®). Seattle: University of Washington; 1993.Google Scholar ... The authors report two cases of intracranial extramedullary hematopoiesis in beta thalassemia. In one of these patients, ... Guidelines for the management of non transfusion dependent thalassaemia (NTDT). Nicosia, Cyprus: Thalassaemia International ...

https://link.springer.com/article/10.1007/s12098-018-2618-z

Beta thalassemia is an inherited blood disorder that affects how hemoglobin is made. Learn about causes, symptoms, ... What are the complications of beta thalassemia?. Complications of beta thalassemia vary depending on the type:. * Thalassemia ... How is beta thalassemia diagnosed?. Beta thalassemia is most often found in people who are from Greek, Italian, African, or ... What causes beta thalassemia?. Beta thalassemia is caused by damaged or missing genes. Two specific genes are involved. There ...

https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/hematology_and_blood_disorders/beta_thalassemia_85,P00081

I have been diagnosed as a Beta Thalassemia Minor since few years ago. I have always been slightly anaemic (around 10.5-11.5 ...

https://www.medhelp.org/posts/Sickle-Cell-Anemia/Thalassemia-Beta-Minor/show/2089067

A major diagnostic consideration is to distinguish mild microcytic anemia due to beta-thalassemia carrier state from microcytic ... Drugs & Diseases , Hematology , Beta Thalassemia Q&A How is beta thalassemia differentiated from other causes of anemia?. ... encoded search term (How is beta thalassemia differentiated from other causes of anemia?) and How is beta thalassemia ... Basu S, Kumar A. Hair-on-end appearance in radiograph of skull and facial bones in a case of beta thalassaemia. Br J Haematol. ...

https://www.medscape.com/answers/206490-184797/how-is-beta-thalassemia-differentiated-from-other-causes-of-anemia

Patients with coinheritance of alpha thalassemia have a milder clinical course because they have a less severe alpha-beta chain ... Drugs & Diseases , Hematology , Beta Thalassemia Q&A How does alpha thalassemia affect the severity of beta thalassemia?. ... Basu S, Kumar A. Hair-on-end appearance in radiograph of skull and facial bones in a case of beta thalassaemia. Br J Haematol. ... Peripheral smear in beta-zero thalassemia minor showing microcytes (M), target cells (T), and poikilocytes. ...

https://www.medscape.com/answers/206490-184787/how-does-alpha-thalassemia-affect-the-severity-of-beta-thalassemia

In the homozygous state, beta thalassemia (ie, thalassemia major) causes severe, transfusion-dependent anemia. ... Beta thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta- ... Patients with the beta thalassemia trait generally have no unusual physical findings. In patients with beta thalassemia major, ... encoded search term (Beta Thalassemia) and Beta Thalassemia What to Read Next on Medscape ...

https://emedicine.medscape.com/article/206490-clinical

... shares her treatment journey with beta-thalassemia, from her childhood to taking care of herself in her adulthood. ... Josephine has become one of the beta-thalassemia communitys fiercest advocates. She publishes a blog called "Thalassemia Diet ... Beta-thalassemia is a serious condition, which is why its important to have a supportive care team to address your symptoms ... Growing up with beta-thalassemia: Taking charge of your care. Josephine Bila, LMSW, shares what she learned during her ...

https://www.bms.com/life-and-science/news-and-perspectives/beta-thalassemia-adulthood.html

The month of May saw major announcements in breakthrough therapies by companies working on the Beta-Thalassemia curatives - ... LentiGlobin BB305 is a potential curative for Beta-Thalassemia. The LentiGlobin BB305 introduces a fully functional human beta- ... Beta-Thalassemia is a life-threatening, blood disorder where the body fails to produce sufficient haemoglobin to thrive. ... The LentiGlobin BB305 is a one-time gene transfer therapy, which promises a permanent cure for Beta-Thalassemia. According to ...

https://www.medindia.net/news/healthinfocus/breakthrough-treatments-for-beta-thalassemia-major-150562-1.htm

Beta thalassaemia A mutation in the beta haemoglobin chains causes beta thalassaemia. Beta thalassemias occur due to ... Beta thalassemia trait is also called as beta thalassemia minor. These are … Normally, beta thalassemia trait does not cause ... Beta thalassemia trait is also called as beta thalassemia minor. There are two types of thalassemia trait: Alpha thalassemia ... Thalassaemia minor can refer to people with either alpha- or beta-thalassaemia. Beta Thalassemia minor or Thalassemia trait: ...

http://ecoloinfo.com/09vnmqy/vyno24.php?tag=b329a5-beta-thalassemia-trait-pregnancy

Depending on the beta thalassemia mutation, people may have no normal hemoglobin (called sickle beta zero thalassemia) or a ... Sickle beta thalassemia is inherited in an autosomal recessive manner. Treatment is supportive and depends on the signs and ... Sickle beta thalassemia is an inherited condition that affects hemoglobin, the protein in red blood cells that carries oxygen ... Home / For Patients and Families / Rare Disease Information / NIH GARD Report: Sickle beta thalassemia ...

https://rarediseases.org/gard-rare-disease/sickle-beta-thalassemia/

Merchant, R., Choudhari, A.J., Verma, M. et al. Intracranial Hematopoiesis in Beta Thalassemia: A Case Series. Indian J Pediatr ... The authors report two cases of intracranial extramedullary hematopoiesis in beta thalassemia. In one of these patients, ... Intracranial extramedullary hematopoiesis in beta-thalassemia. Korean J Radiol. 2012;13:240. ... Guidelines for the management of non transfusion dependent thalassaemia (NTDT). Nicosia, Cyprus: Thalassaemia International ...

https://link.springer.com/article/10.1007/s12098-018-2618-z?error=cookies_not_supported&error=cookies_not_supported&code=fc788f69-3d43-498e-b93e-ee738395f9cf

Beta thalassemia intermedia is less severe than beta thalassemia major and may require episodic blood transfusions. Transfusion ... Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or ... Persons with the thalassemia trait have a normal life expectancy. Persons with beta thalassemia major often die from cardiac ... Alpha thalassemia major with hemoglobin Barts usually results in fatal hydrops fetalis. Beta thalassemia major causes ...

https://www.aafp.org/afp/2009/0815/p339.html

Beta thalassemia minor (or beta thalassemia trait) is when one beta globin gene is mutated. It usually causes mild anemia and ... Beta thalassemia (thal-uh-SEE-me-uh) is an inherited blood disorder in which the body has a problem producing beta globin, a ... Beta thalassemia major (Cooleys anemia) is when both of the beta globin genes are mutated. This is the most severe form of ... Beta thalassemia intermedia is when both beta globin genes are mutated, but the mutations are less severe. It usually causes ...

https://www.childrensmn.org/educationmaterials/parents/article/14491/a-to-z-beta-thalassemia/

A small study finds promise for using gene therapy to treat patients with beta-thalassemia, a blood condition that can cause ... Beta-Thalassemia Treatment With Gene Therapy Reduced Transfusions : Shots - Health News A small study finds promise for using ... Researchers used a gene-carrying virus to fix blood stem cells that were then used to treat patients with beta-thalassemia. ... Results of a study published Wednesday show that 15 of 22 patients with beta-thalassemia who got gene therapy were able to stop ...

https://www.npr.org/sections/health-shots/2018/04/18/602914728/gene-therapy-for-inherited-blood-disorder-reduced-transfusions

In the homozygous state, beta thalassemia (ie, thalassemia major) causes severe, transfusion-dependent anemia. ... Beta thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta- ... encoded search term (Beta Thalassemia) and Beta Thalassemia What to Read Next on Medscape. Related Conditions and Diseases. * ... The therapeutic approach to thalassemia varies between thalassemia minor and thalassemia major. ...

https://emedicine.medscape.com/article/206490-treatment

Beta thalassemia is caused by genetic defects that control the production of hemoglobin, and treatment includes regular blood ... What is beta thalassemia? Beta thalassemia is an inherited blood disorder. This means it is passed down through the parents ... What causes beta thalassemia? Beta thalassemia is caused by a defect of the gene that controls hemoglobin production. There are ... Beta thalassemia major (Cooleys anemia). This is the most severe type of beta thalassemia. It is often found during the first ...

https://childrensnational.org/visit/conditions-and-treatments/blood-marrow/beta-thalassemia-cooleys-anemia

We will develop a simple PCR method to diagnosis alpha-thalassemias. Phase I of the project willconduct feasibility study for ... They can be differentiated by measuring the band intensity of the target chains(alpha1, alpha2) and reference chain (beta-actin ... The kit will be usedfor screening potential carriers with alpha-thalassemia in the United States, Southeast Asia andSouthern ... This should identify patients at risk of having offspring with symptomatic alpha-thalass-emia disorders. The Investigators note ...

https://www.sbir.gov/sbirsearch/detail/88099

beta-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of beta-globin. The defects ... beta-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of beta-globin. The defects ... beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload Adv Hematol. 2010;2010:938640. doi: 10.1155/2010/938640 ... Although beta-thalassemia is one of the first monogenic diseases to be described and represents a global health problem, only ...

https://pubmed.ncbi.nlm.nih.gov/20508726/

The three types of beta thalassemia (BAY-tuh thahl-uh-SEE-mee-uh) are:. *Beta thalassemia minor (also called beta thalassemia ... has beta thalassemia intermedia or beta thalassemia major (Cooleys anemia).. Sometimes a beta thalassemia gene change can be ... Who Gets Beta Thalassemia?. People inherit the genes for beta thalassemia from their parents. A child gets one beta protein ... A gene change in the beta proteins causes beta thalassemia.. In beta thalassemia, the gene change causes an imbalance of ...

https://www.akronchildrens.org/kidshealth/en/parents/beta-thalassemia.html

Home News Fetal Gene Editing with Synthetic Nucleotides Cures Beta-Thalassemia in Mice ... Fetal Gene Editing with Synthetic Nucleotides Cures Beta-Thalassemia in Mice. July 10, 2018. 0 ... In 2016 the team reported on use of the PNA technology in adult mice to correct the β-thalassemia gene defect and effectively ... When the treatment was then tested in the mouse model of β-thalassemia, the team found that fetuses that had received the NP- ...

https://www.genengnews.com/topics/omics/fetal-gene-editing-with-synthetic-nucleotides-cures-beta-thalassemia-in-mice/

Thalassemia. beta-Thalassemia. Anemia, Hemolytic, Congenital. Anemia, Hemolytic. Anemia. Hematologic Diseases. ... ACE-536 Extension Study - Beta Thalassemia. The safety and scientific validity of this study is the responsibility of the study ... tolerability and pharmacodynamic effects of up to 24 months of ACE-536 treatment in adult patients with beta-thalassemia ... to evaluate the long-term safety and tolerability of ACE-536 in adult patients with beta-thalassemia. ...

https://clinicaltrials.gov/show/NCT02268409

Beta thalassemia intermedia may also happen when both of the beta globin genes are mutated, but the mutations are less severe than those that typically cause beta thalassemia major. (kidshealth.org)
Beta thalassemia major and intermedia can lead to serious complications, especially if untreated. (kidshealth.org)
Beta thalassemia is classified into two types depending on the severity of symptoms: thalassemia major (also known as Cooley's anemia) and thalassemia intermedia. (medlineplus.gov)
Thalassemia intermedia is milder than thalassemia major. (medlineplus.gov)
The signs and symptoms of thalassemia intermedia appear in early childhood or later in life. (medlineplus.gov)
people with both types have been diagnosed with thalassemia major and thalassemia intermedia. (medlineplus.gov)
Beta thalassemia intermedia. (kidshealth.org)
People with beta thalassemia intermedia have moderately severe anemia and some will need regular blood transfusions and other medical treatment. (kidshealth.org)
Children with beta thalassemia intermedia or major may not show any symptoms at birth, but usually develop them in the first 2 years of life. (kidshealth.org)
People with beta thalassemia major or intermedia usually have a buildup of iron in the body, either from the disease itself or from the repeated blood transfusions. (kidshealth.org)
Someone who inherits a gene change in both beta proteins (one from each parent) has beta thalassemia intermedia or beta thalassemia major (Cooley's anemia). (kidshealth.org)
People with beta thalassemia intermedia may need blood transfusions and chelation (key-LAY-shun) but not as often as people with beta thalassemia major. (kidshealth.org)
For a type called beta thalassemia intermedia, you may need transfusions at certain times, like when you're sick or before you have surgery. (webmd.com)
Thalassemia intermedia can cause problems based on the severity of the anemia. (hopkinsmedicine.org)
Three main forms have been described: thalassemia minor, thalassemia intermedia, and thalassemia major which vary from asymptomatic or mild symptoms to severe anemia requiring lifelong transfusions. (wikipedia.org)
Those with beta thalassemia intermedia (those who are compound heterozygoutes for the beta thalassemia mutation) usually present later in life with mild to moderate symptoms of anemia. (wikipedia.org)
These complications are mostly found in thalassemia major and intermedia patients. (wikipedia.org)
Additional symptoms of beta thalassemia major or intermedia include the classic symptoms of moderate to severe anemia including fatigue, growth and developmental delay in childhood, leg ulcers and organ failure. (wikipedia.org)
Taher A, Isma'eel H, Cappellini MD. Thalassemia intermedia: revisited. (springer.com)
Alpha thalassemia intermedia, or hemoglobin H disease, causes hemolytic anemia. (aafp.org)
Beta thalassemia intermedia is less severe than beta thalassemia major and may require episodic blood transfusions. (aafp.org)
Beta thalassemia intermedia is when both beta globin genes are mutated, but the mutations are less severe. (childrensmn.org)
The types are beta thalassemia major, intermedia and minor. (childrensnational.org)
To test this theory, Dr. McLaughlin and colleagues from the University of Pennsylvania, University of North Carolina and University of Minnesota, examined whether parthenogenetic embryonic stem cells could be used for tissue repair in a mouse model of thalassemia intermedia. (news-medical.net)
Thalassemia intermedia is an inherited blood disorder in which the body lacks sufficient normal hemoglobin, leading to excessive destruction of red blood cells and anemia. (news-medical.net)
DESIGN AND METHODS: We describe the methods of conception and delivery, as well as the course and outcome of pregnancy including transfusions, iron overload and chelation in 46 women with thalassemia major (58 pregnancies) and in 11 women with thalassemia intermedia (17 pregnancies). (biomedsearch.com)
Conception was achieved after gonadotrophin-induced ovulation in 33 of the women with thalassemia major and spontaneously in all of those with thalassemia intermedia. (biomedsearch.com)
Pregnancy was safe in most women with thalassemia major or intermedia. (biomedsearch.com)
However, women with thalassemia intermedia who had never previously been transfused or who had received only minimal transfusion therapy were at risk of severe alloimmune anemia if blood transfusions were required during pregnancy. (biomedsearch.com)
Rund D, Oron-Karni V, Filon D, Goldfarb A, Rachmilewitz E, Oppenheim A. Genetic analysis of beta-thalassemia intermedia in Israel: diversity of mechanisms and unpredictability of phenotype. (clinicaltrials.gov)
BACKGROUND AND OBJECTIVE: The survival of patients with beta-thalassemia major and intermedia has improved considerably. (haematologica.org)
DESIGN AND METHODS: Respiratory function tests, CO diffusion and arterial blood gas analysis were performed on 19 patients with beta-thalassemia major (9 F, 10 M) and 13 with beta-thalassemia intermedia (6 M, 7 F). All investigations were performed 24 hours before the patients received a blood transfusion or when they were in a stable state hematologic condition. (haematologica.org)
The pulmonary function of patients with beta-thalassemia intermedia seemed to be preserved. (haematologica.org)
Patients are categorized according to their severity of anemia and symptoms are grouped into thalassemia major (a severe homozygous or compound heterozygous condition, also called Cooley's anemia), intermedia and minor (a mild heterozygous condition also known as trait or minima). (clinicaladvisor.com)
Later onset anemia suggests intermedia subtype of β thalassemia. (clinicaladvisor.com)
Beta Thalassemia Intermedia encompasses disorders with wide spectrum of clinical presentation. (clinicaladvisor.com)
Spectrum of severity can range from those with haemoglobin level of 6 grams/deciliter (g/dL) with severe disability to asymptomatic cases with haemoglobin of 10-12 g/dL in mild phenotype of beta thalassemia intermedia. (clinicaladvisor.com)
Thalassaemia intermedia: Patients with symptoms that range from those observed in thalassaemia minor and those in thalassaemia major. (nhsggc.org.uk)
Blood transfusions are required for beta-thalassaemia intermedia and major, but are associated with iron overload complications. (bmj.com)
Compound heterozygosity of beta-thalassaemia with haemoglobin E mutations results in a phenotype more severe than either beta-thalassaemia trait or haemoglobin E mutations alone, similar to beta-thalassaemia major or intermedia. (bmj.com)
Thalassemia minor is further divided into thalassemia minima (a person has little to no symptoms) and thalassemia intermedia (a person has moderate to severe anemia). (mydochub.com)
There are different types of beta thalassemia (minor, intermedia, or major for example) that have much different impacts on a patient's health. (healthtap.com)
In Beta thalassemia intermedia, B +/ B + , both beta chain loci show a partial deletion or inactivation of the gene. (labce.com)

Beta thalassemia minor , or beta thalassemia trait , happens when one of the beta globin genes is mutated. (kidshealth.org)
Beta thalassemia minor (also called beta thalassemia trait ). (kidshealth.org)
People with beta thalassemia trait usually do not have any symptoms. (kidshealth.org)
Someone who inherits the gene change in the beta protein from one parent has beta thalassemia minor (beta thalassemia trait). (kidshealth.org)
Kids with beta thalassemia trait usually don't need treatment. (kidshealth.org)
The presence of thalassemia minor (like sickle cell trait in Africa) afforded protection against malaria, and therefore, this gene thrived. (medicinenet.com)
Beta thalassemia minor or thalassemia trait. (hopkinsmedicine.org)
Beta thalassemia trait (also known as beta thalassemia minor) involves heterozygous inheritance of a beta-thalassemia mutation and patients usually have borderline microcytic, hypochromic anemia and they are usually asymptomatic or have mild symptoms. (wikipedia.org)
A Mentzer index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. (medscape.com)
Patients with the beta thalassemia trait generally have no unusual physical findings. (medscape.com)
The detection of thalassemia trait may provide an explanation for a microcytic anaemia which will, in concert with a normal serum ferritin, rule out iron deficiency and allow the patient to reduce iron supplementation. (ecoloinfo.com)
These are … Normally, beta thalassemia trait does not cause any health issues. (ecoloinfo.com)
The anemia of patients with thalassemia trait increases during the second trimester, as does that with normal controls. (ecoloinfo.com)
Silent carriers of alpha thalassemia and persons with alpha or beta thalassemia trait are asymptomatic and require no treatment. (aafp.org)
Persons with thalassemia should be referred for preconception genetic counseling, and persons with alpha thalassemia trait should consider chorionic villus sampling to diagnose infants with hemoglobin Bart's, which increases the risk of toxemia and postpartum bleeding. (aafp.org)
Persons with the thalassemia trait have a normal life expectancy. (aafp.org)
Approximately 5 percent of the world's population has a globin variant, but only 1.7 percent has alpha or beta thalassemia trait. (aafp.org)
Thalassemia trait affects 5 to 30 percent of persons in these ethnic groups. (aafp.org)
Persons with anemia from thalassemia trait should not take iron supplements unless they have coexistent iron deficiency. (aafp.org)
For many people with beta thalassemia trait, whose only symptom may be mild anemia from time to time, no medical treatment is necessary. (childrensmn.org)
In this study we measured sTfR levels in the cases of beta-thalassemia trait (betaTT) and IDA to see whether it would be a diagnostic tool for the differentiation of betaTT and IDA. (unboundmedicine.com)
Beta Thalassemia minor or beta thalassemia trait carries no symptoms except for mild fatigue reported in studies. (clinicaladvisor.com)
If unusually high plasma iron or serum ferritin is encountered in beta thalassemia trait one should rule out coexisting hemochromatosis or iron supplementation. (clinicaladvisor.com)
Beta-thalassemia trait prevalence of Turkey and other Middle Eastern countries were compared and showed in figure II. (thefreedictionary.com)
Thalassaemia minor: this usually occurs in patients who are heterozygous for one beta thalassaemia mutation (beta thalassamia carriers or bête thalassaemia trait). (nhsggc.org.uk)
A ß-thalassemia may be coinherited with both sickle trait or homozygous sickle disease and will reduce the amount of ß-globin chain production. (clinicaladvisor.com)
The presentation is highly variable, depending on the severity of the ß-thalassemia (from mild dysregulation through to null production and whether it is coinherited with Sickle Cell Anemia or with Sickle Trait (see chapters on Sickle Cell Disease and Sickle Cell Trait). (clinicaladvisor.com)
Hemoglobin S trait with a coinherited α-thalassemia should also be considered when the percentage of hemoglobin S is less than 33% (see Chapter Anemia Associated with Hemoglobin S-Alpha Thalassemia). (clinicaladvisor.com)
If an elevated hemoglobin A2 is not recognized as β-thalassemia, offspring with a partner with benign sickle cell trait could unexpectedly have severe hemoglobin S/Aβ0 disease, rather than benign sickle cell trait. (clinicaladvisor.com)
Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. (healthtap.com)
Having beta thalassemia major or sickle cell disease , or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. (healthtap.com)
I am of Italian decent and have a thalassemia trait. (scinfo.org)
Thalassemia minor or thalassemia trait -- one beta gene has a deletion, resulting in anemia. (mydochub.com)

With thalassemia, the red blood cells are destroyed at a faster rate, leading to anemia , a condition that can cause fatigue and other complications. (kidshealth.org)
Beta thalassemia can cause anemia ranging from mild to severe and is more common in people of Mediterranean, African, and Southeast Asian descent. (kidshealth.org)
Beta thalassemia major (Cooley's anemia) happens when both of the beta globin genes are mutated (changed) and the mutations are severe. (kidshealth.org)
People with beta thalassemia minor may have mild anemia, but usually don't need any medical treatment. (kidshealth.org)
Beta thalassemia major (also called Cooley's anemia ). (kidshealth.org)
People with beta thalassemia major have severe symptoms and life-threatening anemia. (kidshealth.org)
There are two forms of beta thalassemia: thalassemia minor and thalassemia major (also called Cooley's anemia ). (medicinenet.com)
They are thalassemia minor and thalassemia major (which is also called Cooley's anemia ). (medicinenet.com)
Persons with thalassemia minor have (at most) mild anemia (slight lowering of the hemoglobin level in the blood). (medicinenet.com)
Thalassemia major (Cooley's anemia): The child born with thalassemia major has two genes for beta thalassemia and no normal beta-chain gene. (medicinenet.com)
Because of this, thalassemia major has been called Mediterranean anemia. (medicinenet.com)
Thalassemia can cause mild or severe anemia. (hopkinsmedicine.org)
They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. (wikipedia.org)
Individuals with beta thalassemia major (those who are homozygous for thalassemia mutations, or inheriting 2 mutations) usually present within the first two years of life with symptomatic severe anemia, poor growth, and skeletal abnormalities. (wikipedia.org)
How is beta thalassemia differentiated from other causes of anemia? (medscape.com)
A major diagnostic consideration is to distinguish mild microcytic anemia due to beta-thalassemia carrier state from microcytic anemia due to other causes. (medscape.com)
In patients with beta thalassemia major, the physical findings are related to severe anemia, ineffective erythropoiesis, extramedullary hematopoiesis, and iron overload resulting from transfusion and increased iron absorption. (medscape.com)
This is really breakthrough treatment for thalassemia, can it helpful for homolytic anemia or pyruvate keingime deficiency? (medindia.net)
Beta thalassemia major causes hemolytic anemia, poor growth, and skeletal abnormalities during infancy. (aafp.org)
The thalassemias (named from the Greek word for sea, thalassa 1 ) are a group of inherited autosomal recessive hematologic disorders 2 that cause hemolytic anemia because of the decreased or absent synthesis of a globin chain. (aafp.org)
Family physicians need to know how to diagnose thalassemias, how to distinguish them from other causes of a microcytic anemia, and the treatment options for severe forms of thalassemia. (aafp.org)
Beta thalassemia major (Cooley's anemia) is when both of the beta globin genes are mutated. (childrensmn.org)
A small study finds promise for using gene therapy to treat patients with beta-thalassemia, a blood condition that can cause severe anemia. (npr.org)
Results of a study published Wednesday show that 15 of 22 patients with beta-thalassemia who got gene therapy were able to stop or sharply reduce the regular blood transfusions they had needed to alleviate their life-threatening anemia. (npr.org)
Beta thalassemia is an inherited blood disorder in which a child has anemia. (childrensnational.org)
Children with beta thalassemia minor have anemia, but often do not have symptoms. (childrensnational.org)
As a result of the inefficient synthesis of beta-globin, the patients suffer from chronic anemia due to a process called ineffective erythropoiesis (IE). (nih.gov)
Celgene's trial assessed the ability of erythroid maturation agent luspatercept to reduce the need for adults with anemia related to beta thalassemia to undergo red blood cell transfusions. (fiercebiotech.com)
Homozygous thalassemia presents as a severe hemolytic anemia, whereas in the heterozygous state, beta-thalassemia is asymptomatic or onl mildly symptomatic. (hubpages.com)
Thalassemia should be looked for in all children showing persistent or progressive anemia, hepatosplenomegaly and the characteristic facies. (hubpages.com)
Microcytic hypochromic anemia unresponsive to Iron therapy and the presence of numerous target cells and other evidence of hemolysis are strongly suggestive of thalassemia. (hubpages.com)
Beta thalassemia is a genetic disorder characterized by anemia and fatigue as well as bone deformities and organ problems. (23andme.com)
However, when a person has beta thalassemia, a mutation or loss of the gene encoding beta globin impairs the production of hemoglobin, leading to severe anemia and the need for transfusions. (childrenshospital.org)
We conclude that patients with S-beta thal, like sickle-cell anemia patients, present multiple abnormalities of renal function. (biomedsearch.com)
Delta-beta-thalassemia should be suspected in a patient with microcytic red blood cells and erythrocytosis but no significant anemia. (oncologynurseadvisor.com)
Treating sickle cell anemia and beta-thalassemia has been my passion since I first trained as a physician in India," stated Malik. (biospace.com)
Beta-thalassemia is an inherited hemoglobinopathy due to reduced or absent beta-globin chain synthesis leading to ineffective erythropoiesis and anemia," Maria Domenica Cappellini, MD, professor at University of Milan in Italy, told HemOnc Today . (healio.com)
Luspatercept is a first-in-class erythroid maturation agent under development for adults with anemia from beta-thalassemia or myelodysplastic syndrome. (healio.com)
Thalassemias are hemolytic anemias and can be confused with other hemolytic anemia. (clinicaladvisor.com)
Nadim Ahmed, president of global hematology and oncology for Celgene called the approval "an important milestone," since patients with anemia due to beta thalassemia have limited treatment options. (ajmc.com)
sickle cell-thalassemia a hereditary anemia involving simultaneous heterozygosity for hemoglobin S and thalassemia. (thefreedictionary.com)
n type of anemia occurring as a result of reduced synthesis of the beta chains of hemoglobin. (thefreedictionary.com)
Human β-thalassemia is characterized by mutations of β-globin gene, resulting in deficient production of the β-globin chains of Hb molecule (ineffective erythropoiesis) and chronic anemia. (intechopen.com)
There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent. (curehunter.com)
Thalassaemia major: also called Mediterranean anemia or Cooley anemia. (nhsggc.org.uk)
SUMMIT, N.J. & CAMBRIDGE, Mass.--( BUSINESS WIRE )--Celgene Corporation (NASDAQ: CELG) and Acceleron Pharma Inc. (NASDAQ: XLRN) today announced the U.S. Food and Drug Administration (FDA) has approved REBLOZYL ® (luspatercept-aamt) for the treatment of anemia in adult patients with beta thalassemia who require regular red blood cell (RBC) transfusions. (businesswire.com)
There are very limited options for patients living with anemia due to beta thalassemia who are dependent on long term red blood cell transfusions. (businesswire.com)
We are pleased to make REBLOZYL available as a new therapy for these patients to help address their anemia, a significant clinical complication of beta thalassemia. (businesswire.com)
2,3 Treatment options for anemia associated with beta thalassemia are limited, consisting mainly of RBC transfusions, which have the potential to contribute to iron overload, which can cause serious complications such as organ damage. (businesswire.com)
Inheritance of ß-thalassemia with sickle cell anemia reduces the amount of ß-globin produced, and it is immaterial which of the genes carry both mutations. (clinicaladvisor.com)
Beta thalassemias and hemoglobin S have been discussed as discrete clinical entities elsewhere (see chapter on Sickle Cell Anemia). (clinicaladvisor.com)
Thalassemia includes a number of different forms of anemia, which are classified as either alpha thalassemias or beta thalasemias. (nyhq.org)
Do beta thalassemia and sickle cell anemia always reduce life expectancy? (healthtap.com)
A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia , and also inherited one gene mutation for beta thalassemia. (healthtap.com)
The mutation that causes sickle cell anemia is a qualitative abnormality of beta globin. (healthtap.com)
What is the main difference between thalassemia and sickle cell anemia? (healthtap.com)
Coincidental alpha-thalassemia and sickle cell anemia are common in my patients. (healthtap.com)
Beta thalassemia should be suspected in a patient with a microcytic anemia with an erythrocytosis. (cancertherapyadvisor.com)
Beta thalassemia is a microcytic anemia that results from a mutation in one or both alleles of the beta globin gene on chromosome 11. (cancertherapyadvisor.com)
Patients with thalassemia minor may have only a mild microcytic, hypochromic anemia with mild jaundice and splenomegaly. (cancertherapyadvisor.com)
Examination of the automated red blood cell (RBC) indices can be helpful as an initial screen to determine if the patient has iron deficiency anemia versus beta thalassemia. (cancertherapyadvisor.com)
Iron deficiency is the most common cause of microcytic anemia and, thus, must always be considered before making a diagnosis of beta thalassemia. (cancertherapyadvisor.com)
Clinically, Hb S-beta-thalassemia causes symptoms of moderate anemia and signs of sickle cell disease , which are usually less frequent and less severe than those of sickle cell disease. (merckmanuals.com)
Clinically, manifestations depend on the amount of Hb A. Thus, Hb-S-beta 0 thalassemia manifests similarly to sickle cell disease (Hb SS), whereas Hb S-beta+ thalassemia causes symptoms of moderate anemia and some signs of sickle cell disease , which are usually less frequent and less severe than those of pure sickle cell disease. (merckmanuals.com)
Methodology: This study included 100 b-thalassemia major patients who were diagnosed by Hb electrophoresis and were receiving regular blood transfusions for anemia and chelation therapy for prevention of iron overload related complications. (thefreelibrary.com)
Thalassemia includes a number of different forms of anemia. (mydochub.com)
The severity and type of anemia, including the beta thalassemias, depends on the number of genes that are affected. (mydochub.com)
Beta thalassemia major (Cooley's anemia) --both (two) beta chain genes have deletions, causing the most severe type of beta thalassemia. (mydochub.com)
NEWARK, Calif., Jan. 9, 2019 /PRNewswire/ -- Protagonist Therapeutics, Inc. (Nasdaq:PTGX) today announced that the first patient has been dosed in the Phase 2 study of PTG-300, an injectable hepcidin mimetic peptide in development for the treatment of patients with beta thalassemia, a rare disease characterized by chronic anemia and iron overload. (pharmiweb.com)
The global Phase 2 study is a single-arm, open label, multiple-ascending dose design which will evaluate safety, proof-of-concept and dose finding in approximately 84 adolescent and adult patients with anemia associated with non-transfusion-dependent or transfusion-dependent beta thalassemia. (pharmiweb.com)
PTG-300 is an injectable hepcidin mimetic in clinical development for the potential treatment of beta thalassemia, a rare disease characterized by chronic anemia and iron overload. (pharmiweb.com)
PTG-300 is an injectable hepcidin mimetic for the potential treatment of anemia and iron overload related to rare blood diseases with an initial focus on beta thalassemia. (pharmiweb.com)
Promising results from the first clinical trials of globin gene transfer to treat beta-thalassemias-inherited forms of anemia-have eliminated the need for blood transfusions in some individuals. (medicalxpress.com)

Thalassemias are a group of blood disorders that affect the way the body makes hemoglobin. (kidshealth.org)
Beta globin is made on chromosome 11 (beta globin, along with alpha globin, is one of the proteins that makes up hemoglobin). (kidshealth.org)
Beta thalassemia is a blood disorder that reduces the production of hemoglobin . (medlineplus.gov)
In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body. (medlineplus.gov)
Beta-globin is a component (subunit) of hemoglobin . (medlineplus.gov)
Hemoglobin consists of four protein subunits, typically two subunits of beta-globin and two subunits of another protein called alpha-globin. (medlineplus.gov)
A lack of beta-globin leads to a reduced amount of functional hemoglobin. (medlineplus.gov)
Beta thalassemia is an inherited blood disorder in which the body doesn't make hemoglobin normally. (kidshealth.org)
Hemoglobin is made of two alpha proteins and two beta proteins. (kidshealth.org)
In beta thalassemia, the gene change causes an imbalance of hemoglobin proteins. (kidshealth.org)
Beta thalassemia lowers your hemoglobin -- a protein that helps red blood cells carry oxygen to your organs and tissues -- and causes a drop in your red blood cell count. (webmd.com)
Thalassemia patients make defective hemoglobin . (medicinenet.com)
The thalassemias are a group of genetic (inherited) blood disorders that share in common one feature, the defective production of hemoglobin, the protein that enables red blood cells to carry and deliver oxygen. (medicinenet.com)
There are many different mechanisms of defective hemoglobin synthesis and, hence, many types of thalassemia. (medicinenet.com)
When you have thalassemia, your body makes less hemoglobin than normal. (hopkinsmedicine.org)
Beta thalassemias occur due to malfunctions in the hemoglobin subunit beta or HBB. (wikipedia.org)
The body's inability to construct new beta-chains leads to the underproduction of HbA (adult hemoglobin). (wikipedia.org)
Beta thalassemia is a hereditary disease affecting hemoglobin. (wikipedia.org)
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to produce abnormal hemoglobin. (medindia.net)
Sickle beta thalassemia is an inherited condition that affects hemoglobin, the protein in red blood cells that carries oxygen to different parts of the body. (rarediseases.org)
Affected people have a different change ( mutation ) in each copy of their HBB gene: one that causes red blood cells to form a "sickle" or crescent shape and a second that is associated with beta thalassemia, a blood disorder that reduces the production of hemoglobin. (rarediseases.org)
Depending on the beta thalassemia mutation, people may have no normal hemoglobin (called sickle beta zero thalassemia) or a reduced amount of normal hemoglobin (called sickle beta plus thalassemia). (rarediseases.org)
The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. (aafp.org)
Alpha thalassemia major with hemoglobin Bart's usually results in fatal hydrops fetalis. (aafp.org)
Persons with beta thalassemia major require periodic lifelong blood transfusions to maintain hemoglobin levels higher than 9.5 g per dL (95 g per L) and sustain normal growth. (aafp.org)
Beta thalassemia (thal-uh-SEE-me-uh) is an inherited blood disorder in which the body has a problem producing beta globin, a component of hemoglobin, the protein in red blood cells (RBCs) that transports oxygen throughout the body. (childrensmn.org)
Hemoglobin contains two chains of alpha globin and two chains of beta globin. (childrensmn.org)
Beta thalassemia affects the production of hemoglobin. (childrensnational.org)
Beta thalassemia is caused by a defect of the gene that controls hemoglobin production. (childrensnational.org)
We will develop a diagnostic kit for the detectionand quantification of hemoglobin alpha-genes in patients with alpha-thalassemia. (sbir.gov)
They then plan to establish the feasibility of a DNA-PCR mediatedcolor complementary assay to detect hemoglobin alpha gene deletions from dried blood samples and tocombine these two methodologies in to a simple and sensitive diagnostic kit for the alpha-thalassemias.Preliminary work is provided to show the feasibility of the methodology. (sbir.gov)
In these experiments, theydemonstrated that deletion of hemoglobin gene alpha1 or alpha2 can be determined using three sets ofprimers from alpha thalassemia syndrome patients by differential PCR. (sbir.gov)
In preliminary studies, they usedthis method to examine the hemoglobin alpha gene status from nine normal subjects and sevenalpha-thalassemia patients. (sbir.gov)
If the RBC indices suggest a thalassemia, then high pressure liquid chromatography (HPLC) should be performed on lysed RBCs to measure hemoglobin A 2 (α 2 delta 2 ) concentration and hemoglobin F (α 2 gamma 2 ) concentration. (oncologynurseadvisor.com)
As these 2 forms of hemoglobin do not utilize beta chains, both are elevated in beta-thalassemia but not in alpha-thalassemia. (oncologynurseadvisor.com)
A distinguishing feature of delta-beta-thalassemia from hereditary persistence of fetal hemoglobin (HPFH) is the cell distribution of hemoglobin F. It is generally uniform (pancellular) in HPFH, whereas it is heterogeneous in delta-beta-thalassemia. (oncologynurseadvisor.com)
THALAMOSS is aimed at development of universal sets of markers and techniques for stratification of β-thalassaemia patients into treatment subgroups for (a) onset and frequency of blood transfusions, (b) choice of iron chelation, (c) induction of fetal hemoglobin, (d) prospective efficacy of gene-therapy. (europa.eu)
Beta thalassemia, like its better-known cousin sickle-cell disease, is caused by a congenital defect in the globin protein, a key component of hemoglobin, the substance that allows our red blood cells to carry oxygen. (newyorker.com)
Thalassemias are disorders of hemoglobin synthesis. (clinicaladvisor.com)
Thalassemia is diagnosed with hemoglobin electrophoresis. (clinicaladvisor.com)
In β o thalassemia, no hemoglobin A 1 is produced and both hemoglobin F and A 2 are markedly elevated. (clinicaladvisor.com)
α-thalassemia ( alpha-thalassemia ) that caused by diminished synthesis of alpha chains of hemoglobin. (thefreedictionary.com)
β-thalassemia ( beta-thalassemia ) that caused by diminished synthesis of beta chains of hemoglobin. (thefreedictionary.com)
Hemoglobin A 2 (HbA 2 ) consists of two α-globin chains and two δ-globin chains (α 2 δ 2 ), which is found in low levels of normal human blood and may be increased in the blood of patients with β-thalassemia. (intechopen.com)
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. (curehunter.com)
Beta thalassemia is a rare, inherited blood disorder caused by a genetic defect in hemoglobin. (businesswire.com)
Additionally, further optimization of nuclease and guide RNA combinations led to fetal hemoglobin expression of approximately 40 percent in the beta-globin locus-edited erythroid cells. (yahoo.com)
We are encouraged by these pre-clinical results demonstrating cells edited at the beta-globin locus repopulated all lineages of the blood system including, importantly, the red blood cell precursors and the high percentage of fetal hemoglobin expression. (yahoo.com)
Thalassemia refers to a group of inherited disorders in which the amount of hemoglobin produced in the body is greatly reduced. (proprofs.com)
Knowledge of the presence of both the hemoglobin S and ß-thalassemia mutations within a family should raise suspicion for this combination. (clinicaladvisor.com)
It is especially important to determine a patient's iron status, since iron deficiency will lower the percentage of hemoglobin A2 produced and could nullify the expected elevation of A2 in beta thalassemia, leading to a missed diagnosis. (clinicaladvisor.com)
Glycated hemoglobin S elutes with hemoglobin A2 on HPLC and may falsely elevated the value of hemoglobin A2, leading to erroneous suspicion of β-thalassemia. (clinicaladvisor.com)
Finally, β0-thalassemias may mask the presence of a mutant hemoglobin, since the thalassemia completely suppresses expression of the mutant gene. (clinicaladvisor.com)
Thalassemia is an inherited disorder that affects the production of normal hemoglobin (a type of iron-rich protein in red blood cells that carries oxygen to the tissues of the body). (nyhq.org)
Beta thalassemia is caused by abnormal or missing genes that affect the beta chain of the hemoglobin molecule. (nyhq.org)
Hemoglobin S-beta-thalassemia disease is a hemoglobinopathy that causes symptoms similar to those of sickle cell disease, but milder. (merckmanuals.com)
Because of the increased frequency of both Hb S (the abnormal hemoglobin that is responsible for sickle cell disease ) and beta-thalassemia genes in similar population groups, inheritance of both defects is relatively common. (merckmanuals.com)
Beta-thalassemia results from decreased production of the beta-polypeptide chains of hemoglobin due to either mutations or deletions in the beta globin gene, leading to impaired production of Hb A (see also Thalassemias ). (merckmanuals.com)
Hemoglobin S-beta-thalassemia disease is a hemoglobinopathy that causes symptoms similar to those of sickle cell disease, but less severe. (merckmanuals.com)
Thalassemias, autosomal recessive disorders, are among the most prevalent genetic1,2 and major hemoglobin disorders globally3. (thefreelibrary.com)
b-thalassemia results from defective synthesis of beta globin units of hemoglobin, resulting in reduced or absent synthesis of beta globin leading to a spectrum of phenotypic manifestations4. (thefreelibrary.com)
Beta thalassemia is caused by mutations in the beta chain of the hemoglobin molecule. (mydochub.com)
What is hemoglobin E-beta thalassemia? (healthtap.com)
Sickle cell beta thalassemia is a condition in which one of the paired chromosomes for hemoglobin contains a sickle cell mutation and the other contains a beta thalassemia mutation resulting in an abnormal hemoglobin. (healthtap.com)
Beta thalassemia is caused by a mutation in the gene that codes for the beta subunit of hemoglobin, the protein that carries oxygen in the bloodstream. (healthtap.com)
RESULTS: Hemoglobin, hematocrit and mean corpuscular volume were significantly reduced in both beta-thalassemia models, more significantly in Hbb(th/3+), which have the greater, age-dependent, iron overload. (haematologica.org)
Beta thalassemia is a genetic disorder that affects hemoglobin, a protein that blood cells use to carry oxygen. (biotechnews.com.au)
Thalassemia is a hereditary disease related to hemoglobin synthesis. (medscimonit.com)
Although human studies have yet to begin, investigators in a biotech company report that they can use CRISPR/Cas9 gene editing to recreate the rare condition known as hereditary persistence of fetal hemoglobin, or HPFH, which causes some patients with SCD or beta-thalassemia to continue to produce the fully functional fetal rather than adult form of hemoglobin into adulthood. (mdedge.com)
Patients with sickle-cell disease and beta-thalassemia are not sick when they are first born, but symptoms develop shortly after birth as the fetal hemoglobin levels decline, and as adult hemoglobin rises," Dr. Lundberg said. (mdedge.com)
Fetal hemoglobin has been shown to reduce the risk of sickle events in SCD, and reduce symptoms and morbidity of beta-thalassemia. (mdedge.com)
The investigators plan to harvest hematopoietic stem cells from patients with SCD and beta-thalassemia and use CRISPR/Cas9 technology to modify the cells to express the fetal form of hemoglobin. (mdedge.com)
He pointed out, however, that there are many thousands of patients with inherited hemoglobin disorders worldwide and beta-thalassemia, and asked "how do you proceed to implement this very expensive treatment? (mdedge.com)
Enhancing current gene therapy strategies and applying new gene editing tools to correct beta-globin deficiencies and to reactivate fetal hemoglobin production are among the exciting new advances being pursued in the search for a cure for severe globin disorders, as described in Human Gene Therapy . (medicalxpress.com)

There are three types of beta thalassemia, depending upon whether one or two beta globin genes are mutated, and the severity of the mutations. (kidshealth.org)
Mutations in the HBB gene cause beta thalassemia. (medlineplus.gov)
Some mutations in the HBB gene prevent the production of any beta-globin. (medlineplus.gov)
Other HBB gene mutations allow some beta-globin to be produced but in reduced amounts. (medlineplus.gov)
Most often, mutations occur in the promoter regions preceding the beta-globin genes. (wikipedia.org)
This inherited disorder is caused by mutations in the beta-globin gene (HBB gene). (medindia.net)
In contrast, beta-thalassemia alleles can be created by many different mutations including both deletion and non-deletion forms. (wikipedia.org)
This course defines and discusses the disorder beta thalassemia and its genetic mutations that not only differentiate it from alpha thalassemia, but dictate the severity of the disease. (medialab.com)
In both the UAE nationals and expatriates, the beta-thalassemia mutations and their frequency followed a similar trend. (nih.gov)
In beta thalassemia, the beta globin gene is affected by a variety of mutations. (clinicaltrials.gov)
Aug. 8, 2014 (GLOBE NEWSWIRE) -- In the latest demonstration of Transposagen's Footprint-Free™ Gene Editing System, published this week in Genome Research, scientists from the University of California San Francisco corrected mutations in the HBB gene, which cause a form of Beta-thalassemia. (cnbc.com)
Transposagen's Footprint-Free™ Gene Editing System, was recently utilized by researchers from University of California-San Francisco to seamlessly correct mutations in the HBB gene, which cause a form of Beta-thalassemia in iPS cells. (cnbc.com)
However, a wide variety of naturally occurring mutations that result in the clinical syndrome of thalassemia can trigger accelerated mRNA decay thus controlling mRNA quality prior to translation. (nih.gov)
Several hundred mutations of the β-globin gene are known that result in either diminished (β + thalassemia) or absent β globin (β o thalassemia). (clinicaladvisor.com)
Beta Thalassaemia is generally caused by point mutations or chromosome 11, following a recessive inheritance pattern (meaning that a mutation in each allele is needed to develop the disease). (nhsggc.org.uk)
A case-control study aimed to determine the prevalence of C282Y, H63D and S65C mutations of the HFE gene in beta thalassaemia carriers and investigate their influence on iron absorption. (who.int)
A total of 41 beta-thalassaemia carriers and 40 control subjects without haemoglobinopathies were screened for the C282Y, H63D and S65C mutations by polymerase chain reaction-restriction fragment-length polymorphism. (who.int)
The objective of this study was to identify the incidence of β-thalassemia traits, their coinheritance, and mutations, as well as to support the patients already diagnosed with β-thalassemia in East-Western Indian population for better management. (dovepress.com)
Analyses of eight common mutations of thalassemia in India were carried out using polymerase chain reaction-amplification refractory mutation system, end point polymerase chain reaction, and DNA sequencing methods. (dovepress.com)
Beta globin mutations may result in partial loss (beta + allele) or complete loss (beta 0 allele) of beta globin function. (merckmanuals.com)
Genetic syndrome of ineffective erythropoiesis caused by mutations of the beta-globin gene. (bmj.com)
Thalassemia is one of the most common gene mutations in the world. (healthtap.com)
Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the University of Massachusetts Medical School successfully applied the technique to two common blood diseases - sickle cell disease and beta thalassemia - involving mutations in the gene for beta globin protein. (childrenshospital.org)

The main cardiac abnormalities seen as a result of beta thalassemia and iron overload include left ventricular systolic and diastolic dysfunction, pulmonary hypertension, valvulopathy, arrhythmias, and pericarditis. (wikipedia.org)
Siri-Angkul N, Chattipakorn SC, Chattipakorn N. Diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients. (medscape.com)
Atrial fibrillation in β-thalassemia patients with a focus on the role of iron-overload and oxidative stress: A review. (medscape.com)
Role of vitamin C as an adjuvant therapy to different iron chelators in young β-thalassemia major patients: efficacy and safety in relation to tissue iron overload. (medscape.com)
Persons with beta thalassemia major often die from cardiac complications of iron overload by 30 years of age. (aafp.org)
Persons with beta thalassemia major require chelation therapy for iron overload. (aafp.org)
Most thalassemia patients are at risk for iron overload and iron supplementation could be harmful. (clinicaladvisor.com)
In beta-thalassemia major (BTM), iron overload is the joint outcome of multiple blood transfusions and an inappropriately increased iron absorption associated with ineffective erythropoiesis [ 1 ]. (hindawi.com)
People with beta thalassemia often have lifelong regimens of chronic blood transfusions in order to survive, and then need treatment for iron overload due to the transfusions. (ajmc.com)
Secondary iron overload in patients with β-thalassemia is caused by multiple blood transfusions and increased iron absorption. (intechopen.com)
This article has reported modes of actions and challenged such wonderful properties of green tea used to remove excessive iron, scavenge harmful radicals, restore malfunctions of vital organs, and treat patients with β-thalassemia with iron overload. (intechopen.com)
BACKGROUND AND OBJECTIVES: Homozygous beta-thalassemia patients may develop iron overload even if untransfused, due to inappropriately high intestinal iron absorption. (haematologica.org)
Despite the major improvement in therapeutic management of thalassemia major, iron overload is considered a challenging conundrum in these patients and heart disease still remains a major cause of morbidity and mortality in these patients. (springer.com)
Therefore, this study aimed to investigate the prevalence of cardiac iron overload and cardiovascular complications in transfusion-dependent thalassemia patients in the worldwide. (springer.com)
The results of this study show that the prevalence of cardiac iron overload and cardiovascular complications in patients with thalassemia major is almost high. (springer.com)
Therefore, iron chelation and careful monitoring of serum ferritin level will prevent the cardiac iron overload, and interval monitoring of patients with transfusion-dependent thalassemia (TDT) by echocardiography and electrocardiography will help with early detection of cardiovascular complications. (springer.com)

When someone has beta thalassemia, there is a mutation in chromosome 11. (kidshealth.org)
A gene change (mutation) in the alpha proteins causes alpha thalassemia . (kidshealth.org)
those who inherit a beta thalassemic mutation but have no hematologic abnormalities nor symptoms. (wikipedia.org)
A sickle allele is always the same mutation of the beta-globin gene (glutamic acid to valine at amino acid six). (wikipedia.org)
Several genetic mechanisms have been shown to be responsible for thalassemia, These are gene deletion, gene loss due to unequal crossover, defective transcription nRNA, unstable mRNA, and nucleotide mutation leading to premature termination of polypeptide chain synthesis. (hubpages.com)
Gap-PCR (polymerase chain reaction) can also be used to diagnose the delta-beta-thalassemias, using primers on either side of the deletion mutation. (oncologynurseadvisor.com)
The symptoms of beta thalassaemia differ greatly from one patient to another, depending mostly on the severity of the mutation. (nhsggc.org.uk)
Beta thalassemia occurs when there is a mutation of the beta gene, which leads to reduce the production of beta-globin. (proprofs.com)
A genome editing technique called 'base editing' has been used to correct the mutation causing the inherited blood disorder beta-thalassemia in human embryos. (ivf.net)
The study, published in Protein and Cell, follows earlier work by the same team who, in 2015, were the first to use CRISPR/Cas9 on human embryos - also in an attempt to correct the beta-thalassemia mutation. (ivf.net)
The severity of the clinical findings in thalassemia depends on the effect of the specific mutation on production of the β globin chain. (cancertherapyadvisor.com)
β + thalassemia denotes a mutation resulting in marked decrease in β globin chain production, whereas β o thalassemia denotes a mutation resulting in absence of β globin chain production from the affected allele. (cancertherapyadvisor.com)
Beta-thalassaemia is an inherited microcytic anaemia caused by mutation(s) of the beta-globin gene leading to decreased or absent synthesis of beta-globin, resulting in ineffective erythropoiesis. (bmj.com)
MADRID - With some genetic sleight-of-hand, investigators hope to mimic a rare, naturally occurring mutation that protects some patients with beta-thalassemia or sickle-cell disease (SCD) from becoming symptomatic. (mdedge.com)

A genetic counselor can help families understand the different ways beta thalassemia runs in families. (kidshealth.org)
What is the genetic pattern of inheritance of beta thalassemia? (medicinenet.com)
The pattern of genetic transmission of beta thalassemia (and sickle cell disease ) was deciphered by James V. Neel when he was at the University of Rochester (and later at the University of Michigan). (medicinenet.com)
Beta thalassemia is a genetic disease inherited from one or both parents. (hopkinsmedicine.org)
Amelioration of Sardinian beta0 thalassemia by genetic modifiers. (medscape.com)
These treatments have been a regular and frequent part of her life since birth, because she has beta-thalassemia , a rare genetic disorder that reduces her body's ability to produce enough healthy red blood cells, leading to low blood counts. (bms.com)
Bluebirdbio (HQ: Cambridge, Massachusetts) is a clinical-stage company working on potential curatives for genetic disorders like Beta-Thalassemia. (medindia.net)
Genetic and Rare Diseases Information Center: "Beta-thalassemia. (ecoloinfo.com)
Persons at risk of having a child with thalassemia should be offered preconception genetic counseling. (aafp.org)
An estimated 288,000 people have beta-thalassemia worldwide, which makes the disease one of the most common genetic disorders. (npr.org)
Scientists at Yale University and Carnegie Mellon University have used gene editing to effectively cure the genetic blood disorder β-thalassemia, in mouse fetuses, in utero. (genengnews.com)
Genetic disorders such as β-thalassemia can be diagnosed during early pregnancy, offering the potential for genetic correction in utero, but no such treatments exist, and children with β-thalassemia may need to undergo blood transfusions for life, or require bone marrow transplants. (genengnews.com)
Correlate beta thalassemias with their genetic nomenclatures/designations. (medialab.com)
23andMe does not test for all possible genetic variants linked to beta thalassemia and related hemoglobinopathies, and individuals who have zero variants detected still have a chance of being a carrier for beta thalassemia and related hemoglobinopathies. (23andme.com)
The 23andMe Beta Thalassemia and Related Hemoglobinopathies Carrier Status report* looks at 10 genetic variants in the HBB gene linked to these conditions and is most relevant for people of Sardinian, Cypriot, Italian and Greek descent. (23andme.com)
1 Dubai Genetic and Thalassemia Center, Al Wasl Hospital, Dubai, United Arab Emirates. (nih.gov)
Our data strongly suggest the need for a comprehensive thalassemia control program and provides a basis for population screening, genetic counseling and prenatal diagnosis. (nih.gov)
We are looking for genetic factors which influence the severity of beta thalassemia. (clinicaltrials.gov)
We will use a genetic linkage approach to identify modifying factors and by analyzing the efficiency of an mRNA surveillance mechanism that is referred to as nonsense-mediated decay and represents a candidate genetic modifier of beta thalassemia and other genetic disorders. (clinicaltrials.gov)
Beta thalassemia is one of the most common genetic diseases in the world, affecting an estimated three hundred thousand people, with another sixty thousand born every year. (newyorker.com)
Thalassemia is a genetic disorder. (clinicaladvisor.com)
Health care initiatives focusing on prenatal testing and premarital genetic screening aiming to reduce the incidence of β-thalassemia have emerged during the last decade. (dovepress.com)
β-Thalassemia is the most prevalent genetic disorder in India. (dovepress.com)
Couples for premarital medical examination or regular healthcare examination in pregnancy were enrolled in this prospective screening program, which was supported by the two-level network composed of 6 local hospitals for testing thalassemias and follow-up for genetic counseling. (unboundmedicine.com)
The possibility for a genetic intervention to lead to a cure for the beta-thalassemias is increasingly likely the researchers conclude. (medicalxpress.com)

People who are carriers of a thalassemia gene show no thalassemia symptoms and might not know they're carriers. (kidshealth.org)
People with this condition typically have very mild symptoms and require no treatment, but they can pass thalassemia on to their children. (kidshealth.org)
Babies with beta thalassemia major often seem healthy immediately after birth but start to develop symptoms within the first 2 years of life. (kidshealth.org)
The signs and symptoms of thalassemia major appear within the first 2 years of life. (medlineplus.gov)
Many people with thalassemia major have such severe symptoms that they need frequent blood transfusions to replenish their red blood cell supply. (medlineplus.gov)
In these cases, one copy of the altered gene in each cell is sufficient to cause the signs and symptoms of beta thalassemia. (medlineplus.gov)
Depending on the type of beta thalassemia, symptoms can be mild or very severe. (kidshealth.org)
What Are the Signs & Symptoms of Beta Thalassemia? (kidshealth.org)
In most patients with either α-thalassaemia or β-thalassaemia traits there are no signs or symptoms. (ecoloinfo.com)
The presence of sickle-shaped red blood cells, which often breakdown prematurely and can get stuck in blood vessels, combined with the reduction or absence of mature red blood cells leads to the many signs and symptoms of sickle beta thalassemia. (rarediseases.org)
The symptoms of beta thalassemia major occur when an infant is between six and 24 months. (childrensnational.org)
The in utero-treated mice showed dramatic improvements in β-thalassemia symptoms, higher haemoglobin levels and increased long-term survival, when compared with untreated controls. (genengnews.com)
Symptoms of beta thalassemia and related hemoglobinopathies typically develop any time from late infancy (severe form) into adulthood (intermediate form). (23andme.com)
Once a patient shows symptoms of beta thalassemia, treatment is essentially palliative, consisting of regular transfusions of red blood cells from healthy donors. (newyorker.com)
Transfusion-dependent β-thalassaemia is the severe form of β-thalassaemia, in which symptoms are clearly visible in the first six months of life. (cochrane.org)

The person is said to be heterozygous for beta thalassemia. (medicinenet.com)
Interaction of the genes for abnormal hemoglobins and thalassemia gives rise to heterozygous states showing the characteristics of both. (hubpages.com)
The homozygous form is known as thalassemia major and the heterozygous form is known as thalassemia minor. (thefreedictionary.com)

Cure for thalassemia major - from allogeneic hematopoietic stem cell transplantation to gene therapy. (medscape.com)
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia. (medscape.com)
Gene Therapy for Transfusion Dependent Beta-thalassemia (TIGET-BTHAL). (medscape.com)
Since the first successful gene therapy for thalassemia major, in 2007, researchers have worked to improve the efficacy and safety of the procedure. (medscape.com)
Researchers at Nationwide Children's Hospital report a gene therapy strategy that improves the condition of a mouse model of an inherited blood disorder, Beta Thalassemia. (news-medical.net)
Its lead candidate is RVT-1801, an investigational gene therapy for sickle cell disease and beta-thalassemia. (biospace.com)
A pioneering gene therapy could vanquish beta thalassemia, a disorder that affects the red blood cells. (newyorker.com)
Today's data further demonstrate the potentially transformative effects of gene therapy for the treatment of beta-hemoglobinopathies and support our global regulatory strategy for LentiGlobin in beta-thalassemia major, with the goal of potentially accelerated approvals in the EU and U.S.," said David Davidson, M.D., chief medical officer, bluebird bio. (businesswire.com)
Patients with the life-threatening blood disorder beta-thalassemia required fewer blood transfusions after receiving a gene therapy developed by the UK company Orchard Therapeutics, with four out of nine no longer depending on transfusions. (biotechnews.com.au)
Another company developing a gene therapy for beta-thalassemia is the US company bluebird bio , which is currently waiting for EMA market approval of its most advanced beta thalassemia treatment. (biotechnews.com.au)
bluebird bio has applied for market authorization of its investigational LentiGlobin™ gene therapy for the treatment of adolescents and adults with transfusion-dependent β-thalassemia (TDT) and a non-β 0 /β 0 genotype. (b3cnewswire.com)
Jorge Mansilla-Soto, Isabelle Riviere, Farid Boulad, and Michel Sadelain, Memorial Sloan Kettering Cancer Center, New York, NY, are coauthors of the article " Cell and Gene Therapy for the Beta-Thalassemias: Advances and Prospects . (medicalxpress.com)
They present the rationale for using globin gene therapy to cure beta-thalassemias and discuss the four Phase I clinical studies underway in the U.S. and Europe. (medicalxpress.com)
Jorge Mansilla-Soto et al, Cell and Gene Therapy for the Beta-Thalassemias: Advances and Prospects, Human Gene Therapy (2016). (medicalxpress.com)

How does alpha thalassemia affect the severity of beta thalassemia? (medscape.com)
As a result of the various differences in chain production and resulting symptom severity, both alpha and beta thalassemia are classified as being minor or major plus there are various intermediate scenarios. (ecoloinfo.com)
In decreasing order of severity, they may be classified as thalassemia major, thalassemia intermediate, thalassemia minor and thalassemia minima. (hubpages.com)
In addition, we emphasize the importance of these pathways in modulating the severity of the β-thalassemia phenotype. (nih.gov)
Dz severity depends on beta globin expression from thal allele. (healthtap.com)

This is the most severe form of beta thalassemia. (kidshealth.org)
In the study , published in the New England Journal of Medicine, all but one of the 13 patients who had a less severe form of beta-thalassemia were able to completely stop receiving blood transfusions, the researchers reported. (npr.org)
At Hadassah, few of the patients with the severe form of beta thalassemia lived into adulthood. (newyorker.com)

People with beta thalassemia are at an increased risk of developing abnormal blood clots. (medlineplus.gov)
and other associated health problems in people with beta thalassemia. (medlineplus.gov)
In the Bluebird Bio treatment, blood stem cells are taken from patients and modified by a virus that inserts a working copy of the gene that is defective in people with beta-thalassemia. (npr.org)

What are the complications of beta thalassemia? (hopkinsmedicine.org)
Some people with thalassemia are susceptible to health complications that involve the spleen (hypersplenism) and gallstones (due to hyperbilirubinemia from peripheral hemolysis). (wikipedia.org)
Endocrine complications due to haemosiderosis are present in a significant number of patients with beta-thalassemia major (BTM) worldwide and often become barriers in their desire for parenthood. (hindawi.com)
Improvement of survival in patients with β-thalassemia has allowed several clinical morbidities to manifest, including renal complications. (ovid.com)
20 ms) and cardiac complications in thalassemia major patients in the worldwide was 25% (95% CI 22-28%) and 42% (95% CI 37-46%), respectively. (springer.com)

In contrast, transcripts bearing PTCs located less than 55 nt upstream of the last exon-exon junction, or in the 5'-part of exon 3, escape NMD, resulting in the production of truncated proteins that are small enough to be efficiently degraded, along with the α-globin chains in excess, and heterozygotes are still asymptomatic for β-thalassemia. (nih.gov)
We studied gall bladder contractility in 61 children with beta-thalassaemia who were asymptomatic for gall bladder disease and 51 sex- and age-matched controls in Cairo, Egypt, using real-time ultrasonography. (who.int)

In some cases of beta thalassemia, the adjacent delta chain gene is also affected and this gives rise to delta-beta thalassemia. (hubpages.com)
A follow-up test to distinguish delta-beta-thalassemia from HPFH is the globin chain synthesis assay. (oncologynurseadvisor.com)
In delta-beta-thalassemia, there will be a mild alpha chain imbalance with an alpha to non-alpha ratio of about 1.5, whereas there will be balanced production of alpha and beta chains in HPFH. (oncologynurseadvisor.com)

In homozygous beta 0 thalassemia, there is no synthesis of beta chains, while in homozygous beta + thalassemia, beta chains are present, but only in small amounts. (hubpages.com)
A total of 212 patients had homozygous beta-thalassemia and the remaining 101 were compound heterozygotes. (nih.gov)
In addition, 427 expatriate patients were studied: 256 with homozygous beta-thalassemia and 171 were compound heterozygotes. (nih.gov)
Diagnosis of Homozygous beta thalassemia is not difficult. (clinicaladvisor.com)
Sera collected in New York in 1984 from 77 patients with homozygous beta-thalassemia were assayed for antibodies to HTLV-III by ELISA and Western blot techniques. (jimmunol.org)

The clinical picture associated with thalassemia major was first described in 1925 by the American pediatrician Thomas Cooley. (medicinenet.com)
Erythropoiesis is not equally suppressed in transfused males and females with β-thalassemia major: are there clinical implications? (medscape.com)
Patients with coinheritance of alpha thalassemia have a milder clinical course because they have a less severe alpha-beta chain imbalance. (medscape.com)
List the clinical manifestations of the various forms of beta thalassemia. (medialab.com)
The clinical and haematological findings in 19 Liberians probably homozygous for beta thalassaemia are described. (bmj.com)
The partners recently dosed the first patient in a phase I/II clinical trial in adults with beta thalassemia. (biotechnews.com.au)
We are encouraged to move forward with clinical development of PTG-300 in patients with beta thalassemia," commented Dinesh V. Patel, Ph.D., Protagonist President and Chief Executive Officer. (pharmiweb.com)

The type of beta thalassemia you or your child has will help your doctor decide if you need blood transfusions. (webmd.com)
Inheriting two abnormal genes causes the most severe type of beta thalassemia. (nyhq.org)

Compare and contrast laboratory findings in cases of beta thalassemia. (medialab.com)

A phase 3 trial of Celgene's luspatercept in adults with beta thalassemia has hit its primary goal. (fiercebiotech.com)

HBB blockage over time leads to decreased beta-chain synthesis. (wikipedia.org)
Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or absent synthesis of beta globin chains. (aafp.org)
beta-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of beta-globin. (nih.gov)
The condition is designated alpha or beta thalassemia if the synthesis of alpha chain or beta chain is depressed respectively. (hubpages.com)
Due to the absence of beta chain synthesis, the alpha chains which are in excess are precipitated to form inclusions within the erythroid precursors. (hubpages.com)
Beta-thalassemia major ( β -TM) is a hereditary hemogolinopathy caused by impaired synthesis of β -globin chain and requires frequent blood transfusions [ 1 ]. (hindawi.com)
Thalassemia due to one of two or more genes that depress (partially or completely) synthesis of beta-globin chains by the chromosome bearing the abnormal gene. (thefreedictionary.com)
Alpha thalassemia occurs as a result of the deletion of the alpha-globin genes, which leads to a decrease in the synthesis of alpha-globin. (proprofs.com)
This disorder is due to decreased synthesis or absence of beta globulin chains. (healthtap.com)

These mildly affected people are said to have thalassemia minor. (medlineplus.gov)
If you have the mildest form, beta thalassemia minor, you likely won't need transfusions or any other treatment. (webmd.com)
What is the difference between thalassemia minor and major? (medicinenet.com)
Thalassemia minor: The individual with thalassemia minor has only one copy of the beta thalassemia gene (together with one perfectly normal beta-chain gene). (medicinenet.com)
However, persons with thalassemia minor have a normal blood iron level (unless they are iron deficient for other reasons). (medicinenet.com)
No treatment is necessary for thalassemia minor. (medicinenet.com)
Dr. Neel recognized that the parents of children with thalassemia major had thalassemia minor with one beta thalassemia gene. (medicinenet.com)
I have been diagnosed as a Beta Thalassemia Minor since few years ago. (medhelp.org)
The therapeutic approach to thalassemia varies between thalassemia minor and thalassemia major. (medscape.com)
Patients with thalassemia minor usually do not require any specific treatment. (medscape.com)
Its traits and coinheritance vary from mild to severe conditions, resulting in thalassemia minor, intermediate, and major, depending upon many factors. (dovepress.com)
People with thalassemia minor have a 50/50 chance to pass the gene to their offspring, who would also have thalassemia minor, assuming that the other parent is not affected. (nyhq.org)
Thalassemia major is inherited by an autosomal recessive gene, which means that two copies of the gene are necessary to produce the condition, one inherited from each of two carrier parents who have thalassemia minor. (nyhq.org)
Life expectancy is normal with a-and b- thalassemia minor. (healthtap.com)
No. I am going to assume you have beta thalassemia minor. (healthtap.com)
Beta thal minor shouldn't be a problem. (healthtap.com)

Thalassemia minima is mild and causes no problems. (hopkinsmedicine.org)
HbgE/ beta thalassemia is a disease that can be mild or severe. (healthtap.com)

Amid A, Haghi-Ashtiani B, Kirby-Allen M, Haghi-Ashtiani MT. Screening for thalassemia carriers in populations with a high rate of iron deficiency: revisiting the applicability of the Mentzer Index and the effect of iron deficiency on Hb A2 levels. (medscape.com)
These are the carriers of beta thalassemia. (childrensnational.org)
It's important for carriers of the thalassemia gene to know how their children may be affected. (childrensnational.org)
DNA testing can find alpha thalassemia carriers. (childrensnational.org)
The kit will be usedfor screening potential carriers with alpha-thalassemia in the United States, Southeast Asia andSouthern China. (sbir.gov)
In Palestine, 4% of the population are known thalassemia carriers with new cases continuing to appear despite the availability of prenatal testing. (dovepress.com)
H63D, S65C and C282Y allele frequencies were 30.5%, 13.4% and 7.3% respectively in [‎3-thalassaemia carriers and 10.0%, 2.5% and 0.0% respectively in the control group. (who.int)
Six thousands five hundreds and sixty-three individuals in total were found to be the carriers of thalassemias, with 4312 for alpha thalassemia (4.5%) and 2251 for beta thalassemia (2.3%), respectively. (unboundmedicine.com)

Our results indicate that the frequency of beta-globin gene defects including beta-thalassemia, sickle cell gene (betaS) and abnormal hemoglobins is significantly increased and poses a major public health problem in the UAE. (nih.gov)
These stem cells will then have a healthy beta globin gene inserted. (chop.edu)

What Causes Beta Thalassemia? (kidshealth.org)
A gene change in the beta proteins causes beta thalassemia. (kidshealth.org)

In persons with beta thalassemia, there is reduced or absent production of beta globin chains. (medicinenet.com)
Beta thalassemia happens when one of the genes controlling beta globin production is absent or defective, causing faster than normal destruction of RBCs. (childrensmn.org)
Hb S predominates on electrophoresis and is always greater than 50%.Hb A is decreased Hb-S-beta + or absent in Hb-S-beta 0. (merckmanuals.com)

Beta-thalassaemia is a hereditary disease, the prevalence of which is high in persons of Mediterranean, African, and Southeast Asian ancestry. (jmir.org)
In addition to beta thalassemia, PTG-300 has broad potential in the treatment of other disorders, including hereditary hemochromatosis and the myeloproliferative neoplasms polycythemia vera and myelodysplastic syndrome. (pharmiweb.com)

There are two main types of thalassemia: alpha and beta. (hopkinsmedicine.org)
There are different types of thalassemia. (childrensnational.org)

Kids who have beta thalassemia can end up with too much iron in their bodies, either from the disease itself or from getting repeated blood transfusions. (kidshealth.org)
This results in sickle beta thalassemia, a type of sickle cell disease . (kidshealth.org)
If you're the parent of a child with beta thalassemia, it's important to find support for the emotions you may feel as you help your child manage the disease. (webmd.com)
Patients with sickle cell-beta thalassemia may present with painful crises similar to patients with sickle cell disease Sickle cell-beta thalassemia is caused by inheritance of a sickle cell allele from one parent and a beta thalassemia allele from the other. (wikipedia.org)
Although beta-thalassemia is one of the first monogenic diseases to be described and represents a global health problem, only recently has the scientific community started to focus on the real molecular mechanisms that underlie this disease, opening new and exciting therapeutic perspectives for thalassemic patients worldwide. (nih.gov)
In 2016 the team reported on use of the PNA technology in adult mice to correct the β-thalassemia gene defect and effectively cure animals of disease. (genengnews.com)
Findings could hold promise for a new treatment strategy for autosomal dominant diseases like certain forms of Beta Thalassemia, tuberous sclerosis or Huntington's disease. (news-medical.net)
St. Jude Children's Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. (news-medical.net)
Beta Thalassaemia, Alpha Thalassaemia and Sickle Cell Disease Educational Community booklet, p.p. 15-17. (thalassaemia.org.cy)
Iron toxicity is, for these reasons, the major cause of ill-health and finally premature death in thalassaemia patients, even those that are classified initially as having milder forms of the disease. (thalassaemia.org.cy)
for hemoglobinopathies, such as sickle cell disease and beta-thalassemia , and with Shire International GmbH to develop therapeutics for Huntington's disease. (thefreedictionary.com)
We're thrilled that Acceleron's first approved medicine is one with the potential to help patients with beta thalassemia, who have been in need of new treatments for this lifelong disease," said Habib Dable, President and Chief Executive Officer of Acceleron. (businesswire.com)
These data are promising for patients living with beta-thalassemia major and severe sickle cell disease, two devastating, genetically-based hematologic diseases that have a profound impact on both quality of life and life expectancy," said Professor Cavazzana. (businesswire.com)
We are excited that the promising early results for LentiGlobin in beta-thalassemia major are now extending to the first treated patient with severe sickle cell disease. (businesswire.com)
CAMBRIDGE, Mass., June 15, 2019 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. ( EDIT ), a leading genome editing company, today announced results from a follow-up study to assess two different CRISPR genome editing strategies, one targeting the BCL11A erythroid enhancer ( BC11Ae ) and one targeting the beta-globin locus, for the treatment of sickle cell disease and beta-thalassemia. (yahoo.com)
Based on the data, Editas Medicine has initiated IND-enabling activities for EDIT-301, an experimental CRISPR medicine designed to durably treat sickle cell disease and beta-thalassemia by editing the beta-globin locus. (yahoo.com)
Our program is on track towards the clinic, and we have started our IND-enabling activities as we look to develop a best-in-class medicine for the treatment of sickle cell disease and beta-thalassemia. (yahoo.com)
It should be noted that Thalassemia is not just one disease. (proprofs.com)
Also, sickle-beta-thalassemia is a common form of sickle cell disease . (healthtap.com)
My two children both with Sickle Cell Disease type Sickle beta + thalassemia. (scinfo.org)
Although they have sickle beta thal plus, we still live with this disease EVERYDAY! (scinfo.org)
Our ongoing nonmyeloablative allogeneic peripheral blood stem cell (PBSC) transplant protocol (03-H-0170) for patients with severe sickle cell disease (SCD) and B-thalassemia from HLA -matched family donors has excellent results thus far. (aamds.org)
PN-943 is an oral, gut-restricted alpha-4-beta-7 integrin antagonist peptide in development for the treatment of inflammatory bowel disease. (pharmiweb.com)
De Sanctis V, Kattamis C, Canatan D et al (2017) Beta-thalassemia distribution in the old world: an ancient disease seen from a historical standpoint. (springer.com)

Examination of the automated red blood cell (RBC) indices can be helpful as an initial screen to determine if the patient has thalassemia. (oncologynurseadvisor.com)
If there is any question as to whether a patient has thalassemia, it is wise to consult a hematologist before beginning any treatment. (nyhq.org)
The formula % microR-%hypoHe-RDW (M-H-R) has been shown the most sensitive method of predicting if a patient has thalassemia from the RBC indices. (cancertherapyadvisor.com)

Heart failure, growth impairment, diabetes and osteoporosis are life-threatening conditions which can be caused by beta thalassemia major. (wikipedia.org)

The findings suggest that left ventricular diastolic dysfunction occurs early in myocardial impairment in patients with beta thalassaemia major. (bmj.com)
The presence of circulating soluble immune complexes and the level of complement were investigated in sera from 21 patients with beta-thalassaemia major, including both splenectomised and nonsplenectomised patients. (bmj.com)

Abstract We will develop a simple PCR method to diagnosis alpha-thalassemias. (sbir.gov)
Juvenile chronic myelogenous leukemia has high haemoglobin F like beta thalassemia but several laboratory findings like absence of elevated haemoglobin A 2 level, decrease in carbonic anhydrase, primitive cells in the marrow favors the diagnosis of juvenile chronic myelogenous leukemia. (clinicaladvisor.com)
Then confirmative diagnosis of alpha and beta thalassemia was performed on those couples suspected at-risk for severe thalassemia by using the PCR-based molecular diagnostic assays. (unboundmedicine.com)
The couples at-risk for severe thalassemia were counseled and offered prenatal diagnosis and termination of pregnancy in case of an affected fetus. (unboundmedicine.com)
Successful prenatal diagnosis was made for 142 (98 for alpha thalassemia and 44 for beta thalassemia) out of 148 (95.9%) pregnancies at-risk for severe thalassemias. (unboundmedicine.com)

Conclusion: Patients with β-thalassemia major had a high prevalence of subclinical adrenal insufficiency of 16%, hypoparathyroidism of 4.5% with weak negative correlation between the low level of cortisol ≤160 nmol/L and high serum ferritin. (scirp.org)
In Southern Asia, the prevalence of b thalassemia has been reported to be from as low as 2% to as high as 28% in various studies5,6. (thefreelibrary.com)
The aim of this study was to determine the prevalence of gallbladder sludge and stones in beta-thalassemic children. (medscimonit.com)
Longer survival of beta-thalassemic patients leads to a higher prevalence gallbladder sludge and stones. (medscimonit.com)

Thalassemias are inherited blood disorders . (medicinenet.com)
Beta thalassemias (β thalassemias) are a group of inherited blood disorders. (wikipedia.org)
Common endocrine disorders reported in b-thalassemia major patients are short stature, hypogonadism, hypoparathyroidism, hypothyroidism and diabetes mellitus13. (thefreelibrary.com)
Many studies have been done on endocrine disorders including hypoparathyroidism in thalassemia patients and frequency reported varies from centre to centre but largest study so far done included 1861 patients from 25 centres and showed that 3.6% b -thalassemia major patients had hypoparathyroidism14. (thefreelibrary.com)
Since SCD and B-thalassemia are non-malignant disorders of red cells, severe GVHD, lack of donor erythrocyte (prolonged donor red cell aplasia), or graft rejection is collectively considered transplant failure. (aamds.org)

So, if one or both of the genes that tells chromosome 11 to produce beta globin is altered, less beta globin is made. (kidshealth.org)
Which chromosome demonstrates a partial or full gene loci deletion in various forms of beta thalassemia? (medialab.com)
Southern blot analysis with appropriate restriction digestion of genomic DNA and probes to the delta chain gene and the beta chain gene on chromosome 11 will demonstrate a deletion that encompasses the delta chain and the beta chain. (oncologynurseadvisor.com)
There is one beta chain gene on each #11 chromosome, and a total of two #11 chromosomes per person, one inherited from each parent. (nyhq.org)
There is one beta chain gene on each #11 chromosome, for a total of two. (mydochub.com)

Both of the chromosomes have abnormal genes that do not direct the body to make normal beta chains or normal amounts of beta chains. (nyhq.org)

Blood transfusions and chelation do not cure beta thalassemia. (kidshealth.org)
Lucarelli G, Galimberti M, Polchi P. Marrow transplantation in patients with thalassemia responsive to iron chelation therapy. (medscape.com)
Currently, the standard protocol for treatment of Beta-Thalassemia major is lifelong blood transfusions along with regular iron chelation therapy either through infusion or oral medications. (medindia.net)
The standard of care for patients with beta-thalassemia is blood transfusion and iron chelation to remove the iron accumulated by transfusion. (healio.com)
Removing excess iron through iron chelation , is the second major pillar of thalassaemia management. (thalassaemia.org.cy)
Objectives: to determine the levels of calcium and phosphorus in transfusion-dependant b-thalassemia major patients who were on chelation therapy being followed at Fatimid Foundation, Peshawar. (thefreelibrary.com)
Conclusion: Low serum calcium is very prevalent in transfusion-dependent beta thalassemia major patients in our set up possibly due to poor chelation as was confirmed by our study where 49% of patients had hypocalcemia. (thefreelibrary.com)
With the advent of chelation therapy, the survival of thalassemia major patients have increased and they are entering even into third and fourth decades of life11. (thefreelibrary.com)
One hundred fifty-three beta-thalassemia patients on a long-term transfusion/chelation program were selected by a cluster randomized method and were evaluated ultrasonographically for the presence of sludge and biliary lithiasis. (medscimonit.com)

This is he most severe form of ß-thalassemia: those with thalassaemia major need to have regular blood transfusions from infancy onwards in order to survive. (nhsggc.org.uk)

If you have the most severe form, beta thalassemia major, you'll need regular transfusions. (webmd.com)

There are two forms of beta thalassemia. (medicinenet.com)
Differentiate among the various forms of beta thalassemia. (medialab.com)
Identify synonyms for the various forms of beta thalassemia. (medialab.com)

SAN DIEGO - Adults with transfusion-dependent beta-thalassemia experienced significant reductions in red blood cell transfusion burden with luspatercept, according to results of a randomized, double-blind, placebo-controlled phase 3 study presented at ASH Annual Meeting and Exposition. (healio.com)
Background: Adrenal and parathyroid insufficiency are uncommon in patients with transfusion dependent Beta Thalassemia (β-TM). (scirp.org)
Adrenal gland dysfunction is an uncommon endocrine complication in patients with blood transfusion dependent Beta-Thalassemia Major (β-TM) [ 1 ]. (scirp.org)
Celgene and Acceleron announced that the Food and Drug Administration (FDA) has granted Fast Track designations to luspatercept for use in two separate indications: for the treatment of patients with transfusion dependent beta-thalassemia and for the treatment of patients with non-transfusion dependent beta-thalassemia. (empr.com)
Transfusion dependent beta thalassemia patients (any genotype) undergo peripheral blood stem cell harvest following mobilization with the lenograstim and plerixafor. (bloodjournal.org)
The study is designed to evaluate the safety and preliminary efficacy of PTG-300 in patients with transfusion-dependent or non-transfusion-dependent beta thalassemia. (pharmiweb.com)

People inherit the genes for beta thalassemia from their parents. (kidshealth.org)

In a child with beta-thalassemia who received a transplant with sex-mismatched umbilical cord blood and neonatal blood, fluorescent in situ hybridization (FISH) with probes to X and Y chromosomes revealed an extra Y signal in 19.3% of the hepatocytes and in 38.9% of the pretransplant peripheral blood cells, yielding YY/Y ratios of 0.24 and 0.64, respectively. (nih.gov)

Anatomy4

Diseases13

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes12

Disciplines and Occupations1

Information Science1

Geographicals5

A prospective study on TT virus infection in transfusion-dependent patients with beta-thalassemia. (1/842)

Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette. (2/842)

Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemia. (3/842)

Busulphan level and early mortality in thalassaemia patients after BMT. (4/842)

A complex haemoglobinopathy diagnosis in a family with both beta zero- and alpha (zero/+)-thalassaemia homozygosity. (5/842)

Impairment of Plasmodium falciparum growth in thalassemic red blood cells: further evidence by using biotin labeling and flow cytometry. (6/842)

Immunological analysis of beta-thalassemic mouse intestinal proteins reveals up-regulation of sucrase-isomaltase in response to iron overload. (7/842)

Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation. (8/842)

Thalassemia

beta-Thalassemia

Hemoglobin E

alpha-Thalassemia

Fetal Hemoglobin

Globins

Hemoglobinopathies

Hemoglobin A2

alpha-Globins

Chelation Therapy

Hemoglobin J

Sicily

Arabia

Hemoglobins, Abnormal

Hemoglobin A

Iron Overload

Hemoglobinometry

Erythrocytes, Abnormal

Blood Transfusion

Anemia, Sickle Cell

Homozygote

Hemoglobins

Erythrocyte Count

Erythrocyte Indices

Heterozygote Detection

Reticulocytes

Erythropoiesis

Ferritins

Iron Chelating Agents

Splenectomy

Heterozygote

Erythrocytes

Erythrocyte Membrane

Deferoxamine

5'-Nucleotidase

Pyridones

Interleukin-1beta

beta-Globins

Base Sequence

Hemoglobin H

Mutation

beta 2-Microglobulin

Iron

Bone Marrow Transplantation

Phenotype

India

Sickle Cell Trait

Receptors, Adrenergic, beta

Integrin beta3

Hemosiderosis

delta-Thalassemia

Hemoglobin, Sickle

Transforming Growth Factor beta

Anemia, Hypochromic

Osmotic Fragility

Hemoglobin C

Hematopoiesis, Extramedullary

RNA, Messenger

Integrin alpha5beta1

Integrin beta4

Italy

Integrin alpha6beta4

delta-Globins

Integrin beta Chains

Benzoates

beta 2-Glycoprotein I

Erythrocyte Aging

Electronics, Medical

Integrin alpha4beta1

Anemia

Hemoglobin C Disease

Genes

Hemoglobin SC Disease

Melanesia

Integrin alpha2beta1

Receptors, Adrenergic, beta-2

A prospective study on TT virus infection in transfusion-dependent patients with beta-thalassemia. (1/842)

Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette. (2/842)

Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemia. (3/842)

Busulphan level and early mortality in thalassaemia patients after BMT. (4/842)