beta-Lipotropin
A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.
Endorphins
One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.
Interleukin-1beta
beta 2-Microglobulin
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands. (1/105)
The isolation of an untriakontapeptide from camel pituitary extracts has been described. Its structure has been determined and shown to be identical to the sequence of carboxyl-terminal 31 amino acids of ovine beta-lipotropin. The peptide possesses very low lipotropic activity but significant opiate activity. (+info)Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin. (2/105)
The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays. (+info)beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins. (3/105)
The hypophysial homomeric peptide beta-lipotropin (beta-LPH-[1-91]) has no morphinomomimetic activity in a bioassay (myenteric plexus-longitudinal muscle of the guinea pig's ileum) or binding assays with stereospecific opiate-receptors of rat brain synaptosome preparations. Incubating beta-LPH-[1-91] at neutral pH with the supernatant aqueous extracts of rat brain generates (fragments of beta-LPH with) morphinomimetic activity in the same assay systems. These results are related to the recently recognized structural relationships between beta-LPH, the newly isolated peptides met-enkephalin (beta-LPH-[61-65]) and alpha-endorphin (beta-LPH-[61-76]) and also to the biologically active fragments of analogs: beta-LPH-[61-64], beta-LPH-[61-65[-NH2, (Met(O)65)-BETA-LPH-[61-65], beta-LPH-[61-69], and beta-LPH-[61-69]. Enzymatic biogenesis of these morphinomimetic peptides would preclude localizing them as such in cellular or subcellular elements with currently available methodology. (+info)Morphinomimetic activity of synthetic fragments of beta-lipotropin and analogs. (4/105)
In the myenteric plexus-longitudinal muscle bioassay, beta-endorphin, i.e., beta-lipotropin (beta-LPH)-[61-91], has a potency of 450 with confidence limits of 281-966 when Met5-enkephalin is used as a reference standard with a potency of 100. The primary amide and the ethylamide of Met5-enkephalin have potencies statistically overlapping with that of beta-endorphin. The primary amide of alpha-endorphin has twice the potency of the free acid form of alpha-endorphin. An intact NH2-terminal tyrosine is not necessary for full intrinsic activity. The shortest fragment of beta-LPH with morphinomimetic activity is beta-LPH-[61-64]. (+info)Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2. (5/105)
The bioactivity of neuropeptides can be regulated by a variety of post-translational modifications, including proteolytic processing. Here, gene-targeted mice producing defective prohormone convertase 2 (PC2) were used to examine the post-translational processing of two neuroendocrine prohormones, pro-opiomelanocortin (POMC) and pro-orphanin FQ (pOFQ)/nociceptin (N), in the brain. Reversed-phase HPLC and gel-exclusion chromatography were combined with specific radioimmunoassays to analyze the processing patterns of these two prohormones in the hypothalamus and the amygdala. In the case of POMC, the lack of PC2 activity completely prevented carboxy-shortening of beta-endorphins and greatly diminished conversion of beta-lipotropin to gamma-lipotropin and beta-endorphin. Although conversion of beta-lipotropin to beta-endorphin decreased, the lack of PC2 activity caused an increase in beta-lipotropin and beta-endorphin levels in the mutant animals, but no increases in POMC or biosynthetic intermediates were seen. The extent of OFQ/N production was significantly lower in PC2-deficient mice and there was an accumulation of relatively large amounts of pOFQ/N and biosynthetic intermediates. These results demonstrate that PC2 is directly involved in the biogenesis of two brain neuropeptides in vivo and suggest that the specific prohormone and cellular context influences neuropeptide processing by PCs. (+info)Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. (6/105)
Two mammalian gene products, PC2 and PC3, have been proposed as candidate neuroendocrine-precursor processing enzymes based on the structural similarity of their catalytic domains to that of the yeast precursor-processing endoprotease Kex2. In this report we demonstrate that these two proteases can cleave proopiomelanocortin (POMC) in the secretory pathway of mammalian cells. Similarly to pituitary corticotrophs, PC3 expressed in processing-deficient BSC-40 cells cleaved native mouse POMC at the -Lys-Arg- sites flanking corticotropin. The -Lys-Arg- within beta-lipotropin was less efficiently cleaved to release beta-endorphin. Expression of PC2 together with PC3 resulted in efficient conversion of beta-lipotropin, as occurs in pituitary melanotrophs. Furthermore, coexpression of PC2 together with mouse POMC in bovine adrenomedullary chromaffin cells resulted in conversion of beta-lipotropin to gamma-lipotropin and beta-endorphin in the regulated secretory pathway. Finally, the processing selectivities of PC3 and PC2 expressed together in BSC-40 cells were determined by using a series of mutant mouse POMCs containing all possible pairs of basic residues at certain sites. The observed pattern of cleavage site selectivities mimicked that of the endogenous endoproteases of the insulinoma and bovine adrenomedullary chromaffin cells, suggesting that PC2 and PC3 may represent important core endoproteases in the catalysis of prohormone processing in many neuroendocrine cell types. (+info)Effect of calcium ions on the processing of pro-opiomelanocortin by bovine intermediate lobe pro-opiomelanocortin-converting enzyme. (7/105)
The effect of Ca2+ on the extent and pattern of processing of pro-opiomelanocortin and an N-terminal fragment by a purified pituitary secretory vesicle, soluble aspartic endoprotease, was studied. Ca2+ stimulated the first cleavage of pro-opiomelanocortin by pro-opiomelanocortin-converting enzyme to yield 21-23 kDa adrenocorticotropin and beta-lipotropin, but its effect was minimal. The production of adrenocorticotropin from the 21-23 kDa intermediate was stimulated approximately 2.3-fold in the presence of 10 mM Ca2+, and processing of beta-lipotropin to beta-endorphin was stimulated about 1.3-1.4-fold by 5-10 mM Ca2+. The production of gamma-melanotropin-immunoreactive material from bovine N-pro-opiomelanocortin(1-77) was stimulated approximately 1.3-fold at both 100 microM and 1.5-2.0 mM Ca2+. Further characterization of the gamma-melanotropin-immunoreactive material by HPLC demonstrated that the major products were gamma 3-[Lys]melanotropin and gamma 3-melanotropin at both Ca2+ concentrations. These results indicate that pro-opiomelanocortin-converting enzyme is stimulated by Ca2+. (+info)Plasma immunoreactive corticotrophin and lipotrophin in Cushing's syndrome and Addison's disease. (8/105)
Plasma immunoreactive corticotrophin (ACTH) and lipotrophin (LPH) were measured in patients with raised circulating concentrations from a pituitary or an ectopic source. They were measured again in seven patients after they had received hydrocortisone. Plasma ACTH concentrations were higher than LPH concentrations in patients with a pituitary source of their hormones, whereas this relation was reversed when the source was ectopic. After hydrocortisone administration the half life of immunoreactive ACTH was 40 minutes and that of LPH 95 minutes, resulting in a reversal of the normal relation of ACTH to LPH. The use of two antisera with different specificities for measuring LPH has further shown that pituitary LPH differs from ectopic LPH. Relatively less gamma-LPH than beta-LPH was produced from ectopic sources, the relation being reversed in patients with a pituitary source for their raised concentrations. Measuring plasma LPH as well as ACTH might therefore help in deciding whether a patient with Cushing's syndrome has a pituitary or ectopic source of ACTH, which sometimes presents a difficult clinical problem. (+info)![High Purity [Tyr9]-β-MSH, porcine; (Tyr49)-β-Lipotropin (41-58), porcine for Various Application Researchers - Elabscience](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAMAAAAoLQ9TAAAAIVBMVEUAbbkAbbkAbblHcEwAbbkAbbkAbbkAbbkAbbkAbbkAbbm5gl6QAAAACnRSTlPy6gIALbqiDcVWsF7bjgAAADhJREFUGJVjYGZi5IIDNmZmBuwCDFAAF2BhhgNiBThYwYCDHd0W3AKcLBDARIG1MKczMqHZgk0AALWEBQVs1O3wAAAAAElFTkSuQmCC)
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Pro-opiomelanocortin; POMC; Pro-Opiocortin
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Lipotropin
beta-Lipotropin at the US National Library of Medicine Medical Subject Headings (MeSH) gamma-Lipotropin at the US National ... γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids. Gamma lipotropin is ... Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ... β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments ...
Derek George Smyth
Smyth, D.G. (2016) Lipotropin & beta-endorphin: a perspective. J. Mol Endocrinol.56, T13-25. (Articles with short description, ... Bradbury, A.F., Smyth, D.G., Snell, C.R. Birdsall, N.J.M. and Hulme, E.C. (1976) C-Fragment of lipotropin has a high affinity ... Smyth, D.G., Snell, C.R. and Massey, D.E. (1978) Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary ... In a classic series of papers from 1975 to 1982, he and his team (26-34) showed that the C-terminal fragment of lipotropin, ...
Endorphins
"Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia". ... In mammals, pro-peptide convertase 1 (PC1) cleaves POMC into adrenocorticotropin (ACTH) and beta-lipotropin (β-LPH). β-LPH, a ... Smyth, D G (May 2016). "60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective". Journal of Molecular Endocrinology. 56 ... Peptide convertase 2 (PC2) is responsible for cleaving β-LPH into β-endorphin and γ-lipotropin. Formation of α-endorphin and γ- ...
Beta-Endorphin
Smyth DG (May 2016). "60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective". Journal of Molecular Endocrinology. 56 ( ... and β-lipotropin. The formation of β-endorphin is then the result of cleavage of the C-terminal region of β-lipotropin, ... Beta-Endorphin or β-Endorphin is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons ... The C-terminal sequence of γ-lipotropin turned out to be the primary sequence of the β-endorphin. Malenka RC, Nestler EJ, Hyman ...
Leu-enkephalin
Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ...
Addison's disease
... and beta-lipotropin. The subunit ACTH undergoes further cleavage to produce alpha-MSH, the most important MSH for skin ...
Pro-opiomelanocortin converting enzyme
Loh YP (September 1986). "Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro- ...
Corticotropin-like intermediate peptide
... and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The ...
List of MeSH codes (D06)
... beta-msh MeSH D06.472.699.631.525.690.583.115 - gamma-msh MeSH D06.472.699.631.525.883 - thyrotropin MeSH D06.472.699.631. ... lipotropin MeSH D06.472.699.631.525.690.583 - melanocyte-stimulating hormones MeSH D06.472.699.631.525.690.583.050 - alpha-msh ... beta-msh MeSH D06.472.734.525.690.583.115 - gamma-msh MeSH D06.472.734.525.883 - thyrotropin MeSH D06.472.734.525.883.249 - ... inhibin-beta subunits MeSH D06.472.699.350 - insulin MeSH D06.472.699.350.408 - insulin, isophane MeSH D06.472.699.350.532 - ...
List of MeSH codes (D12.644)
MeSH D12.644.050.200 - defensins MeSH D12.644.050.200.050 - alpha defensins MeSH D12.644.050.200.075 - beta defensins MeSH ... lipotropin MeSH D12.644.548.691.525.690.583 - melanocyte-stimulating hormones MeSH D12.644.548.691.525.690.583.050 - alpha-msh ... beta-msh MeSH D12.644.400.460.115 - gamma-msh MeSH D12.644.400.465 - msh release-inhibiting hormone MeSH D12.644.400.470 - msh- ... gtp-binding protein beta subunits MeSH D12.644.360.375.730 - gtp-binding protein gamma subunits MeSH D12.644.360.375.940 - ...
Cushing's syndrome
... β-lipotropin, and γ-lipotropin, which contain weak MSH function, can act on the melanocortin 1 receptor. A variant of Cushing's ... oral tablets a 11-beta-hydroxylase enzyme inhibitor was approved by FDA for treating those patients who cannot undergo ...
Distribution of the Messenger RNA Coding for the Common Precursor of Corticotropin and beta-Lipotropin within the Bovine...
Characterization of a common precursor to corticotropin and beta-lipotropin: identification of beta-lipotropin peptides and ... In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands ... Distribution of the Messenger RNA Coding for the Common Precursor of Corticotropin and beta-Lipotropin within the Bovine ... Distribution of the messenger RNA coding for the common precursor of corticotropin and beta-lipotropin within the bovine ...
POMC gene: MedlinePlus Genetics
Three similar peptides called alpha-, beta-, and gamma-melanocyte stimulating hormones (α-, β-, and γ-MSH) are also cut from ... A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab. 2006 Feb;3(2 ... A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab. 2006 Feb;3(2):141-6. doi: 10.1016/j ... beta-MSH. *CLIP. *COLI_HUMAN. *corticotropin-like intermediary peptide. *corticotropin-lipotropin. *gamma-LPH ...
Endocrine System Anatomy: Overview, Gross Anatomy
For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, ... Endocrine pancreas consists of 4 cell types: 1) Alpha (A) cells secret glucagon, 2) Beta (B) cells secret insulin, 3) Delta ... If the insulin deficiency is very severe, the beta cell abnormalities of pancreas cause ketoacidosis, hyperosmolar coma and ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. ...
DeCS 2007 - Changed terms
beta-Lipotropin(1-10),porcine CAS PNA-0471 - Apnoke Scientific Ltd - The Expert in Amino acids and PeptidesApnoke Scientific...
beta-Lipotropin(1-10),porcine CAS PNA-0471 provided by Apnoke Scientific Ltd who is the expert in amino acids, peptides and ... beta-Lipotropin(1-10),porcine CAS PNA-0471. In Peptide CAS Number(Or APNoke Number for Non-CAS Products): PNA-0471. Product ... beta-Lipotropin(1-10),porcine. Sequence: Glu-Leu-Ala-Gly-Ala-Pro-Pro-. Glu-Pro-Ala. Molecule Formula: C42H66N10O15. Molecule ...
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Kimball, C.D. Do endorphin residues of beta-lipotropin in hormone reinforce reproductive functions? Am. J. Obstet. Gynecol. 143 ... Goland, R.S.; Wardlaw, S.L.; Stark, R.I.; Frantz, A.G. Human plasma beta-endorphin during pregnancy, labor, and delivery. J. ... Fraioli, F.; Genazzani, A.R. Human placental beta-endorphin. Gynecol. Obstet. Invest. 11: 37-44; 1980. ...
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Code System Concept
PORRO, Carlo Adolfo
Beta-lipotropin is the major component of the plasma opioid response to surgical stress in humans. 1-gen-1987 Porro, C. A.; ... Beta-lipotropin is the major component of the plasma opioid response to surgical stress in humans.. ... Central beta-endorphin system involvement in the reaction to acute tonic pain. 1-gen-1991 Porro, C. A.; Tassinari, G.; ... Central beta-endorphin system involvement in the reaction to acute tonic pain.. ...
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Characterization of a common precursor to corticotropin and beta-lipotropin: identification of beta-lipotropin peptides and ... Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature. 1979 Mar 29;278(5703):423-7. doi ... Bloom F, Battenberg E, Rossier J, Ling N, Guillemin R. Neurons containing beta-endorphin in rat brain exist separately from ... Shiomi H, Watson SJ, Kelsey JE, Akil H. Pretranslational and posttranslational mechanisms for regulating beta-endorphin- ...
Beta Endorphin Levels in PCOS Women: Relationship With Insulin Secretion | Pastore | Journal of Endocrinology and Metabolism
Beta Endorphin Levels in PCOS Women: Relationship With Insulin Secretion ... beta-Endorphin and beta-lipotropin plasma levels in hirsute women: correlation with body weight. J Clin Endocrinol Metab. 1980; ... Laatikainen T, Salminen K, Virtanen T, Apter D. Plasma beta-endorphin, beta-lipotropin and corticotropin in polycystic ovarian ... Beta Endorphin Levels in PCOS Women: Relationship With Insulin Secretion. Lisa M. Pastorea, f, Patricia L. Doughertya, b, ...
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Corticotropin-lipotropin1
- POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. (nsjbio.com)
ACTH5
- For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, prompt the suprarenal cortex to release hormones. (medscape.com)
- Ta grupa obuhvata ACTH, alfa-MSH, beta-MSH i gama-MSH. (wikipedia.org)
- The corticotropes of the pars distalis produce the pre‐pro‐hormone POMC which is converted into beta‐lipotropin and ACTH, which are subsequently released into the circulation. (veteriankey.com)
- alpha melanocyte‐stimulating hormone ( α‐MSH ), beta‐endorphin ( β‐END ), corticotropin‐like intermediate lobe peptide ( CLIP ), and ACTH (McFarlane 2011 ). (veteriankey.com)
- it derives from proopiomelanocortin (POMC), a preprohormone that undergoes several posttranslational modifications resulting in the production of many peptide fragments, including ACTH, melanotropin gamma (γ-MSH), lipotropin gamma (γ-LPH), and endorphin. (medscape.com)
Peptides1
- Three similar peptides called alpha-, beta-, and gamma-melanocyte stimulating hormones (α-, β-, and γ-MSH) are also cut from the POMC protein. (medlineplus.gov)
Endorphin6
- Cell-free translation product containing corticotropin and beta-endorphin encoded by messenger RNA from anterior lobe and intermediate lobe of bovine pituitary. (wikidata.org)
- Central beta-endorphin system involvement in the reaction to acute tonic pain. (unimore.it)
- An understanding of the relationship between beta endorphin (βE) with insulin, glucose and gonadotropins may explain how non-pharmacologic treatment options such as exercise and acupuncture may be beneficial to women with Polycystic Ovary Syndrome (PCOS). (jofem.org)
- Differential regulation of beta-endorphin in the anterior pituitary, intermediate lobe, hypothalamus and brain stem. (semanticscholar.org)
- Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies. (semanticscholar.org)
- Well-characterized antisera to porcine beta-endorphin were used to localize immunoreactive sites in cryostat sections of formaldehyde-fixed rat brain and are anatomically distinguishable from enkephalin-containing nerve cell and fiber pathways. (semanticscholar.org)
Hypothalamus1
- Adrenocorticotropin and β-lipotropin (β-LPH) have been localized by immunoperoxidase methods in nerve cells and fibers of the hypothalamus and brain stem of the ewe. (rupress.org)
Opioid1
- Beta-lipotropin is the major component of the plasma opioid response to surgical stress in humans. (unimore.it)
Subunit3
- 1987). „A receptor-binding region in human choriogonadotropin/lutropin beta subunit" . (wikipedia.org)
- TSH is a glycoprotein and consists of two subunits, the alpha and the beta subunit. (wikidoc.org)
- The β ( beta ) subunit ( TSHB ) is unique to TSH, and therefore determines its receptor specificity. (wikidoc.org)
Hormona3
- Beta polipeptid luteinizirajućeg hormona ( lutropinska podjedinica beta ) je protein koji je kod ljudi kodiran LHB genom . (wikipedia.org)
- Geni beta lanaca horionskih gonadotropina i luteinizirajućeg hormona su dodirni na hromozomu 19q13.3. (wikipedia.org)
- On kodira beta podjedinicu luteinizirajućeg hormona (LH). (wikipedia.org)
Enkephalin1
- WHEN Hughes et al.1 first described the sequences of the enkephalins, they pointed out that methionine-enkephalin (met-enkephalin) could be found in β-lipotropin (β-LPH 61-65). (semanticscholar.org)
Endorphins7
- Studies of lipotropins, melanotropins and endorphins on one hand, and of adrenocorticotropin on the other, has given rise to the concept of a multipotent precursor molecule recently renamed proopiomelanocortin. (nih.gov)
- These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. (aabioetica.org)
- A pituitary prohormone, Beta-lipotropin, is thought to be a precursor of both the endorphins and Beta-malanotropin. (nih.gov)
- Endorphins are derived from the carboxy-terminal portion of Beta-lipotropin (residues 61-91) and Beta-melanotropin from residues 41-58. (nih.gov)
- There was also an increase in beta-endorphins in the blood. (cuyamungueinstitute.com)
- beta-endorphins are the terminal sequence of 31 amino acids in the polypeptide chain of beta-lipotropin and have a greater analgesic potency than morphine. (cuyamungueinstitute.com)
- The presence of beta-endorphins is responsible for the characteristic sense of well-being that accompanies ecstatic trance. (cuyamungueinstitute.com)
Carboxy-terminal portion1
- It was found to be identical with the carboxy-terminal portion 61-91 of human beta-lipotropin (beta-LPH). (drugbank.com)
Precursor2
- The preferential sites of cleavage of the precursor to produce its biologically active components are made of pairs of basic amino acid residues as described for the biosynthesis of beta-MSH and pro-insulin. (nih.gov)
- Thus the model of beta-LPH precursor, proposed as early as in 1967, is now applicable to the biosynthesis of all other neuropeptides. (nih.gov)
Adrenal1
- adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. (aabioetica.org)
Gonadotropin1
- Beta-endorphin/beta-lipotropin release and gonadotropin secretion after acute exercise in normal males. (escholarship.org)
Opiate1
- The smallest fragment of Beta-lipotropin which retains opiate activity is methionine-enkephalin which corresponds to Beta-lipotropin (61-65). (nih.gov)
Secretion2
- The data suggest that beta-EP does not exert a suppressive effect on LH secretion after acute exercise in normal human males. (escholarship.org)
- Whether the suppression of LH secretion after acute exercise in unconditioned males is due to factor(s) cosecreted with beta-LPH, an increase in brain beta-EP or to alternate mechanisms such as alteration in central dopaminergic or GABAergic tone remains to be established. (escholarship.org)
Hormone1
- g-Lipotropin is then metabolized to form b-Melanocyte Stimulating Hormone. (interscienceinstitute.com)
Thymosin3
- Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Thymosin Beta 10 (TMSb10) in serum, plasma, tissue homogenates and other biological fluids. (nrftd.org)
- Description: A competitive Inhibition ELISA kit for detection of Thymosin Beta 10 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (nrftd.org)
- Description: Quantitative sandwich ELISA for measuring Human Thymosin beta-10 (TMSB10) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (nrftd.org)
Plasma2
- Acute exercise resulted in a rise in plasma beta-LPH levels that returned to base line when measured 60 min after exercise. (escholarship.org)
- Plasma beta-EP levels did not demonstrate any rise when measured immediately after 20 min of exercise or at 60 min after exercise. (escholarship.org)
Activity1
- Sympathetic nervous system activity, which also controls blood pressure, acting through the beta 1 adrenergic receptors. (leparisien.fr)
Active1
- However, beta-LPH is not active up to concentrations of 10(-6) M. (drugbank.com)
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