A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.
One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.

Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands. (1/105)

The isolation of an untriakontapeptide from camel pituitary extracts has been described. Its structure has been determined and shown to be identical to the sequence of carboxyl-terminal 31 amino acids of ovine beta-lipotropin. The peptide possesses very low lipotropic activity but significant opiate activity.  (+info)

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin. (2/105)

The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.  (+info)

beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins. (3/105)

The hypophysial homomeric peptide beta-lipotropin (beta-LPH-[1-91]) has no morphinomomimetic activity in a bioassay (myenteric plexus-longitudinal muscle of the guinea pig's ileum) or binding assays with stereospecific opiate-receptors of rat brain synaptosome preparations. Incubating beta-LPH-[1-91] at neutral pH with the supernatant aqueous extracts of rat brain generates (fragments of beta-LPH with) morphinomimetic activity in the same assay systems. These results are related to the recently recognized structural relationships between beta-LPH, the newly isolated peptides met-enkephalin (beta-LPH-[61-65]) and alpha-endorphin (beta-LPH-[61-76]) and also to the biologically active fragments of analogs: beta-LPH-[61-64], beta-LPH-[61-65[-NH2, (Met(O)65)-BETA-LPH-[61-65], beta-LPH-[61-69], and beta-LPH-[61-69]. Enzymatic biogenesis of these morphinomimetic peptides would preclude localizing them as such in cellular or subcellular elements with currently available methodology.  (+info)

Morphinomimetic activity of synthetic fragments of beta-lipotropin and analogs. (4/105)

In the myenteric plexus-longitudinal muscle bioassay, beta-endorphin, i.e., beta-lipotropin (beta-LPH)-[61-91], has a potency of 450 with confidence limits of 281-966 when Met5-enkephalin is used as a reference standard with a potency of 100. The primary amide and the ethylamide of Met5-enkephalin have potencies statistically overlapping with that of beta-endorphin. The primary amide of alpha-endorphin has twice the potency of the free acid form of alpha-endorphin. An intact NH2-terminal tyrosine is not necessary for full intrinsic activity. The shortest fragment of beta-LPH with morphinomimetic activity is beta-LPH-[61-64].  (+info)

Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2. (5/105)

The bioactivity of neuropeptides can be regulated by a variety of post-translational modifications, including proteolytic processing. Here, gene-targeted mice producing defective prohormone convertase 2 (PC2) were used to examine the post-translational processing of two neuroendocrine prohormones, pro-opiomelanocortin (POMC) and pro-orphanin FQ (pOFQ)/nociceptin (N), in the brain. Reversed-phase HPLC and gel-exclusion chromatography were combined with specific radioimmunoassays to analyze the processing patterns of these two prohormones in the hypothalamus and the amygdala. In the case of POMC, the lack of PC2 activity completely prevented carboxy-shortening of beta-endorphins and greatly diminished conversion of beta-lipotropin to gamma-lipotropin and beta-endorphin. Although conversion of beta-lipotropin to beta-endorphin decreased, the lack of PC2 activity caused an increase in beta-lipotropin and beta-endorphin levels in the mutant animals, but no increases in POMC or biosynthetic intermediates were seen. The extent of OFQ/N production was significantly lower in PC2-deficient mice and there was an accumulation of relatively large amounts of pOFQ/N and biosynthetic intermediates. These results demonstrate that PC2 is directly involved in the biogenesis of two brain neuropeptides in vivo and suggest that the specific prohormone and cellular context influences neuropeptide processing by PCs.  (+info)

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. (6/105)

Two mammalian gene products, PC2 and PC3, have been proposed as candidate neuroendocrine-precursor processing enzymes based on the structural similarity of their catalytic domains to that of the yeast precursor-processing endoprotease Kex2. In this report we demonstrate that these two proteases can cleave proopiomelanocortin (POMC) in the secretory pathway of mammalian cells. Similarly to pituitary corticotrophs, PC3 expressed in processing-deficient BSC-40 cells cleaved native mouse POMC at the -Lys-Arg- sites flanking corticotropin. The -Lys-Arg- within beta-lipotropin was less efficiently cleaved to release beta-endorphin. Expression of PC2 together with PC3 resulted in efficient conversion of beta-lipotropin, as occurs in pituitary melanotrophs. Furthermore, coexpression of PC2 together with mouse POMC in bovine adrenomedullary chromaffin cells resulted in conversion of beta-lipotropin to gamma-lipotropin and beta-endorphin in the regulated secretory pathway. Finally, the processing selectivities of PC3 and PC2 expressed together in BSC-40 cells were determined by using a series of mutant mouse POMCs containing all possible pairs of basic residues at certain sites. The observed pattern of cleavage site selectivities mimicked that of the endogenous endoproteases of the insulinoma and bovine adrenomedullary chromaffin cells, suggesting that PC2 and PC3 may represent important core endoproteases in the catalysis of prohormone processing in many neuroendocrine cell types.  (+info)

Effect of calcium ions on the processing of pro-opiomelanocortin by bovine intermediate lobe pro-opiomelanocortin-converting enzyme. (7/105)

The effect of Ca2+ on the extent and pattern of processing of pro-opiomelanocortin and an N-terminal fragment by a purified pituitary secretory vesicle, soluble aspartic endoprotease, was studied. Ca2+ stimulated the first cleavage of pro-opiomelanocortin by pro-opiomelanocortin-converting enzyme to yield 21-23 kDa adrenocorticotropin and beta-lipotropin, but its effect was minimal. The production of adrenocorticotropin from the 21-23 kDa intermediate was stimulated approximately 2.3-fold in the presence of 10 mM Ca2+, and processing of beta-lipotropin to beta-endorphin was stimulated about 1.3-1.4-fold by 5-10 mM Ca2+. The production of gamma-melanotropin-immunoreactive material from bovine N-pro-opiomelanocortin(1-77) was stimulated approximately 1.3-fold at both 100 microM and 1.5-2.0 mM Ca2+. Further characterization of the gamma-melanotropin-immunoreactive material by HPLC demonstrated that the major products were gamma 3-[Lys]melanotropin and gamma 3-melanotropin at both Ca2+ concentrations. These results indicate that pro-opiomelanocortin-converting enzyme is stimulated by Ca2+.  (+info)

Plasma immunoreactive corticotrophin and lipotrophin in Cushing's syndrome and Addison's disease. (8/105)

Plasma immunoreactive corticotrophin (ACTH) and lipotrophin (LPH) were measured in patients with raised circulating concentrations from a pituitary or an ectopic source. They were measured again in seven patients after they had received hydrocortisone. Plasma ACTH concentrations were higher than LPH concentrations in patients with a pituitary source of their hormones, whereas this relation was reversed when the source was ectopic. After hydrocortisone administration the half life of immunoreactive ACTH was 40 minutes and that of LPH 95 minutes, resulting in a reversal of the normal relation of ACTH to LPH. The use of two antisera with different specificities for measuring LPH has further shown that pituitary LPH differs from ectopic LPH. Relatively less gamma-LPH than beta-LPH was produced from ectopic sources, the relation being reversed in patients with a pituitary source for their raised concentrations. Measuring plasma LPH as well as ACTH might therefore help in deciding whether a patient with Cushing's syndrome has a pituitary or ectopic source of ACTH, which sometimes presents a difficult clinical problem.  (+info)

Beta-lipotropin (β-LPH) is a 91-amino acid polypeptide hormone that is derived from proopiomelanocortin (POMC), along with other bioactive peptides such as adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormones (MSH), and β-endorphin. It is produced and released by the anterior pituitary gland in response to stress or corticotropin-releasing hormone (CRH) stimulation.

β-Lipotropin has been found to have several physiological functions, including the regulation of lipid metabolism, appetite control, and pain perception. It also exhibits opioid activity due to its ability to bind to opioid receptors in the brain, although its potency is much lower compared to other endogenous opioids like β-endorphin.

In addition to its role as a hormone, β-lipotropin has been studied for its potential therapeutic applications, particularly in the treatment of obesity and addiction. However, further research is needed to fully understand its mechanisms and clinical efficacy.

Endorphins are a type of neurotransmitter, which are chemicals that transmit signals in the nervous system and brain. The term "endorphin" comes from "endogenous morphine," reflecting the fact that these substances are produced naturally within the body and have effects similar to opiate drugs like morphine.

Endorphins are released in response to stress or pain, but they also occur naturally during exercise, excitement, laughter, love, and orgasm. They work by interacting with the opiate receptors in the brain to reduce the perception of pain and promote feelings of pleasure and well-being. Endorphins also play a role in regulating various physiological processes, including appetite, mood, and sleep.

In summary, endorphins are natural painkillers and mood elevators produced by the body in response to stress, pain, or enjoyable activities.

Interleukin-1 beta (IL-1β) is a member of the interleukin-1 cytokine family and is primarily produced by activated macrophages in response to inflammatory stimuli. It is a crucial mediator of the innate immune response and plays a key role in the regulation of various biological processes, including cell proliferation, differentiation, and apoptosis. IL-1β is involved in the pathogenesis of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis. It exerts its effects by binding to the interleukin-1 receptor, which triggers a signaling cascade that leads to the activation of various transcription factors and the expression of target genes.

Beta-2 microglobulin (β2M) is a small protein that is a component of the major histocompatibility complex class I molecule, which plays a crucial role in the immune system. It is found on the surface of almost all nucleated cells in the body and is involved in presenting intracellular peptides to T-cells for immune surveillance.

β2M is produced at a relatively constant rate by cells throughout the body and is freely filtered by the glomeruli in the kidneys. Under normal circumstances, most of the filtrated β2M is reabsorbed and catabolized in the proximal tubules of the nephrons. However, when the glomerular filtration rate (GFR) is decreased, as in chronic kidney disease (CKD), the reabsorption capacity of the proximal tubules becomes overwhelmed, leading to increased levels of β2M in the blood and its subsequent appearance in the urine.

Elevated serum and urinary β2M levels have been associated with various clinical conditions, such as CKD, multiple myeloma, autoimmune disorders, and certain infectious diseases. Measuring β2M concentrations can provide valuable information for diagnostic, prognostic, and monitoring purposes in these contexts.

beta-Lipotropin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) gamma-Lipotropin at the U.S. National ... γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids. Gamma lipotropin is ... Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ... β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments ...
"Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia". ... In mammals, pro-peptide convertase 1 (PC1) cleaves POMC into adrenocorticotropin (ACTH) and beta-lipotropin (β-LPH). β-LPH, a ... Smyth, D G (May 2016). "60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective". Journal of Molecular Endocrinology. 56 ... Peptide convertase 2 (PC2) is responsible for cleaving β-LPH into β-endorphin and γ-lipotropin. Formation of α-endorphin and γ- ...
Smyth DG (May 2016). "60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective". Journal of Molecular Endocrinology. 56 ( ... and β-lipotropin. The formation of β-endorphin is then the result of cleavage of the C-terminal region of β-lipotropin, ... β-Endorphin (beta-endorphin) is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons ... The C-terminal sequence of γ-lipotropin turned out to be the primary sequence of the β-endorphin. Malenka RC, Nestler EJ, Hyman ...
Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ...
... and beta-lipotropin. The subunit ACTH undergoes further cleavage to produce alpha-MSH, the most important MSH for skin ...
Loh YP (September 1986). "Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro- ...
... and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The ...
... beta-msh MeSH D06.472.699.631.525.690.583.115 - gamma-msh MeSH D06.472.699.631.525.883 - thyrotropin MeSH D06.472.699.631. ... lipotropin MeSH D06.472.699.631.525.690.583 - melanocyte-stimulating hormones MeSH D06.472.699.631.525.690.583.050 - alpha-msh ... beta-msh MeSH D06.472.734.525.690.583.115 - gamma-msh MeSH D06.472.734.525.883 - thyrotropin MeSH D06.472.734.525.883.249 - ... inhibin-beta subunits MeSH D06.472.699.350 - insulin MeSH D06.472.699.350.408 - insulin, isophane MeSH D06.472.699.350.532 - ...
MeSH D12.644.050.200 - defensins MeSH D12.644.050.200.050 - alpha defensins MeSH D12.644.050.200.075 - beta defensins MeSH ... lipotropin MeSH D12.644.548.691.525.690.583 - melanocyte-stimulating hormones MeSH D12.644.548.691.525.690.583.050 - alpha-msh ... beta-msh MeSH D12.644.400.460.115 - gamma-msh MeSH D12.644.400.465 - msh release-inhibiting hormone MeSH D12.644.400.470 - msh- ... gtp-binding protein beta subunits MeSH D12.644.360.375.730 - gtp-binding protein gamma subunits MeSH D12.644.360.375.940 - ...
... β-lipotropin, and γ-lipotropin, which contain weak MSH function, can act on the melanocortin 1 receptor. A variant of Cushing's ... oral tablets a 11-beta-hydroxylase enzyme inhibitor was approved by FDA for treating those patients who cannot undergo ...
beta-Lipotropin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) gamma-Lipotropin at the U.S. National ... γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids. Gamma lipotropin is ... Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ... β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments ...
Results: Both serum levels of beta-endorphin and oxytocin were significantly lower in patients than those in healthy controls ( ... but beta-endorphin levels did correlate significantly with physical aggression (p = 0.026, Spearman test). Conclusions: Serum ... β-lipotropin (β-LPH) and, as another component of the latter, β-melanocyte-stimulating hormone (β-MSH). β-Endorphin is a 31- ... Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression by Olga V. Roschina ...
beta-Lipotropin. Lypressin. Lysine Vasopressin. Prolactin Release-Inhibiting Hormone. Prolactin Release-Inhibiting Factors. ...
beta-Lipotropin. Lypressin. Lysine Vasopressin. Prolactin Release-Inhibiting Hormone. Prolactin Release-Inhibiting Factors. ...
beta-Lipotropin. Lypressin. Lysine Vasopressin. Prolactin Release-Inhibiting Hormone. Prolactin Release-Inhibiting Factors. ...
beta lipotropin (88-91). *beta-lph (88-91). *l-tyrosine, 3,5-diiodo-n-l-phenylalanyl- ...
For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, ... Endocrine pancreas consists of 4 cell types: 1) Alpha (A) cells secret glucagon, 2) Beta (B) cells secret insulin, 3) Delta ... If the insulin deficiency is very severe, the beta cell abnormalities of pancreas cause ketoacidosis, hyperosmolar coma and ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. ...
For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, ... Endocrine pancreas consists of 4 cell types: 1) Alpha (A) cells secret glucagon, 2) Beta (B) cells secret insulin, 3) Delta ... If the insulin deficiency is very severe, the beta cell abnormalities of pancreas cause ketoacidosis, hyperosmolar coma and ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. ...
A decreased blood cortisol level results in increased pituitary ACTH production and increased blood beta-lipotropin level. Beta ... lipotropin has melanocyte-stimulating activity and, together with ACTH, causes the hyperpigmentation of skin and mucous ...
... had the Mr of beta-lipotropin and 27% had the Mr of beta-endorphin. In the neurointermediate lobe, all beta-endorphin ... beta-lipotropin and beta-endorphin with equimolar sensitivity. In the anterior lobe, immunoreactive (ir) beta-endorphin was ... beta-lipotropin and beta-endorphin with equimolar sensitivity. In the anterior lobe, immunoreactive (ir) beta-endorphin was ... beta-lipotropin and beta-endorphin with equimolar sensitivity. In the anterior lobe, immunoreactive (ir) beta-endorphin was ...
... (beta-alanyl-L-histidine) is a dipeptide of the amino acids beta-alanine and histidine. It is highly concentrated in ... Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin). Gastrointestinal hormones. Cholecystokinin - ... Carnosine has been proven to scavenge radical oxygen species (ROS) as well as alpha-beta unsaturated aldehydes formed from ...
... beta polypeptide Identifiers Symbol FSHB Entrez 2487 HUGO 3964 OMIM ... The beta subunits vary. FSH has a beta subunit of 118 amino acids (FSHB), which confers its specific biologic action and is ... lipotropin). ... The gene for the FSH beta subunit is located on chromosome ... The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits. The alpha subunits of LH, FSH, TSH, and hCG ...
"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin". ...
"Pancreas islets in metabolic signaling--focus on the beta-cell". Frontiers in Bioscience. 13 (13): 7156-7171. May 2008. doi: ... sel PP dan sel beta di sana.[31] ... negative regulation of interleukin-1 beta production. *gastric ...
Terminal prostaglandin synthases have been identified that are responsible for the formation of other prostaglandins. For example, hematopoietic and lipocalin prostaglandin D synthases (hPGDS and lPGDS) are responsible for the formation of PGD2 from PGH2. Similarly, prostacyclin (PGI2) synthase (PGIS) converts PGH2 into PGI2. A thromboxane synthase (TxAS) has also been idenfitied. Prostaglandin F synthase (PGFS) catalyzes the formation of 9α,11β-PGF2α,β from PGD2 and PGF2α from PGH2 in the presence of NADPH. This enzyme has recently been crystallyzed in complex with PGD2[4] and bimatoprost[5] (a synthetic analogue of PGF2α). ...
Nuclear beta-catenin accumulation as reliable marker for the differentiation between cystic craniopharyngiomas and rathke cleft ... In addition, other peptides related to the proopiomelanocortin (POMC) precursor molecule, including β-lipotropin, β-endorphin, ...
Endorphins, Lipotropins, Pro-Opi *SBP0102 - ß-Endorphin, human. *SBP0103 - ß-Endorphin, porcine ... Fmoc-Beta-Alanine-OH. *Fmoc-Cys(Acm)-OH. *Fmoc-Cys(trt)-OH ... Endorphins, Lipotropins, Pro-Opi *SBP0102 - ß-Endorphin, human ...
Three similar peptides called alpha-, beta-, and gamma-melanocyte stimulating hormones (α-, β-, and γ-MSH) are also cut from ... A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab. 2006 Feb;3(2 ... A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab. 2006 Feb;3(2):141-6. doi: 10.1016/j ... beta-MSH. *CLIP. *COLI_HUMAN. *corticotropin-like intermediary peptide. *corticotropin-lipotropin. *gamma-LPH ...
For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, ... Endocrine pancreas consists of 4 cell types: 1) Alpha (A) cells secret glucagon, 2) Beta (B) cells secret insulin, 3) Delta ... If the insulin deficiency is very severe, the beta cell abnormalities of pancreas cause ketoacidosis, hyperosmolar coma and ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. ...
beta-Lipotropin. Lypressin. Lysine Vasopressin. Prolactin Release-Inhibiting Hormone. Prolactin Release-Inhibiting Factors. ...
Lipotropin beta; AltName: Full=Beta-LPH; Contains: RecName: Full=Lipotropin gamma; AltName: Full=Gamma-LPH; Contains: RecName: ... beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) mRNA, complete cds. ... beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hor; complete cds, without stopcodon.. ... Full=Melanotropin beta; AltName: Full=Beta-MSH; Contains: RecName: Full=Beta-endorphin; Contains: RecName: Full=Met-enkephalin ...
For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, ... Endocrine pancreas consists of 4 cell types: 1) Alpha (A) cells secret glucagon, 2) Beta (B) cells secret insulin, 3) Delta ... If the insulin deficiency is very severe, the beta cell abnormalities of pancreas cause ketoacidosis, hyperosmolar coma and ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. ...
Loh YP and Gainer H (1978) The role of glycosylation on the biosynthesis, degradation and secretion of the ACTH-beta-lipotropin ... Loh YP (1986) Kinetic studies on the processing of beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin ... Michael D, Geng X, Cawley N, Loh Y P, Rhodes C, Drain P and Chow R (2004) Fluorescent cargo proteins in pancreatic beta cells: ... Barg J, Rius A, Bem WT, Belcheva MM, Loh YP and Coscia CJ (1992) Differential development of beta-endorphin and mu opioid ...
Isolation and structural organization of the human corticotropin--beta-lipotropin precursor gene. Takahashi H, Teranishi Y, ... NH2-terminal amino acid sequence and peptide mapping of purified human beta-lipotropin: comparison with previously proposed ...
beta-Lipotropin Current Synonym true false 3737080019 Beta-lipotropin Current Synonym true false ...
Lipotropin beta-LPH beta-Lipotrophin Registry Number. 9035-55-6. CAS Type 1 Name. Lipotropin. Public MeSH Note. 2007; see ... beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.. Terms. beta- ... beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.. Entry Term(s) ... beta-Lipotropin Preferred Concept UI. M0012607. Registry Number. 9035-55-6. Scope Note. A 90-amino acid peptide derived from ...
Lipotropin beta-LPH beta-Lipotrophin Registry Number. 9035-55-6. CAS Type 1 Name. Lipotropin. Public MeSH Note. 2007; see ... beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.. Terms. beta- ... beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.. Entry Term(s) ... beta-Lipotropin Preferred Concept UI. M0012607. Registry Number. 9035-55-6. Scope Note. A 90-amino acid peptide derived from ...
... beta-lipotropin (β-LPH), the enkephalins, and the endorphins. POMC and MSH can cause hyperpigmentation of the skin and are only ... These include pro-opiomelanocortin (POMC, which gives rise to ACTH), alpha- and beta-melanocyte-stimulating hormone (MSH), ... beta-blockers, angiotensin, and prostaglandins. Inhibitors of vasopressin release include alcohol, alpha-blockers, and ...
For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, ... Endocrine pancreas consists of 4 cell types: 1) Alpha (A) cells secret glucagon, 2) Beta (B) cells secret insulin, 3) Delta ... If the insulin deficiency is very severe, the beta cell abnormalities of pancreas cause ketoacidosis, hyperosmolar coma and ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. ...
For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, ... Endocrine pancreas consists of 4 cell types: 1) Alpha (A) cells secret glucagon, 2) Beta (B) cells secret insulin, 3) Delta ... If the insulin deficiency is very severe, the beta cell abnormalities of pancreas cause ketoacidosis, hyperosmolar coma and ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. ...
N0000011162 beta-Lactams N0000170341 beta-Lipotropin N0000167729 beta-Mannosidase N0000170378 beta-MSH N0000167717 beta-N- ... beta 2-Glycoprotein I N0000169400 beta 2-Microglobulin N0000007226 beta Carotene N0000169947 beta Catenin N0000169677 beta ... beta-Crystallin B Chain N0000169029 beta-Crystallins N0000168523 beta-Cyclodextrins N0000170293 beta-Defensins N0000170404 beta ... N0000006720 beta-Galactosidase N0000178562 beta-Globins N0000169396 Beta-Globulins N0000168529 beta-Glucans N0000179145 beta- ...
... beta-lipotropin, and beta-END. Physiological validation was provided by the measurement of beta-END-like immunoreactivity in a ... beta MSH, ACTH, beta-lipotropin, or beta-endorphin. Bovine anterior pituitary, intermediate-posterior pituitary, and ... indicative of beta 2-receptors. Use of beta 1- and beta 2-subtype selective inhibitors also supported the interpretation that ... These results suggest a limited processing of the ACTH-beta-lipotropin precursor to gamma 1 MSH in human tissues, although a ...
beta-Lactams D2.886.675.966.500 D2.886.108. D4.75.80.875.99.221. beta-Lipotropin D6.472.699.631.525.475.480 D6.472.699.631. ... Replaced for 2008 by beta-Adrenergic Receptor Kinases). beta-Defensins D12.776.543.695.54.200.75. beta-Endorphin D6.472.699.631 ... gamma-Lipotropin D6.472.699.631.525.475.518 D6.472.699.631.525.600.518. gamma-MSH D6.472.699.631.525.475.524 D6.472.699.631. ... beta-MSH D6.472.699.631.525.475.492 D6.472.699.631.525.600.492. D6.472.699.631.525.475.531.750.75 D6.472.699.631.525.600. ...
beta-Lactams D2.886.675.966.500 D2.886.108. D4.75.80.875.99.221. beta-Lipotropin D6.472.699.631.525.475.480 D6.472.699.631. ... Replaced for 2008 by beta-Adrenergic Receptor Kinases). beta-Defensins D12.776.543.695.54.200.75. beta-Endorphin D6.472.699.631 ... gamma-Lipotropin D6.472.699.631.525.475.518 D6.472.699.631.525.600.518. gamma-MSH D6.472.699.631.525.475.524 D6.472.699.631. ... beta-MSH D6.472.699.631.525.475.492 D6.472.699.631.525.600.492. D6.472.699.631.525.475.531.750.75 D6.472.699.631.525.600. ...
... diverse Relatedness of shortening nurses will activate a synthesis of lymphocytes with an Cytosolic machinery beta-lipotropin, ... hydrophobic series strands activation was aciduria to TGF-beta and be 55S vascular binding( Chi et al. In dopamine to TGF-beta ... The beta-TrCP membrane is not certain( immune factor). 2014) but parts contain trafficked that prometaphase is IL33( Cayrol & ... All beta translocation contains associated into SMASE not or through conjugation( MeSeH). Sec found from views is acetylated to ...
D4.75.80.875.99.221 beta-Lipotropin D6.472.699.631.525.475.480 D6.472.699.631.525.600.480 beta-MSH D6.472.699.631.525.475.492 ... beta-Defensins D12.776.543.695.54.200.75 beta-Endorphin D6.472.699.631.525.475.239 D6.472.699.631.525.600.239 beta-Lactams ... D4.75.80.875.99.722.270 beta-Adrenergic Receptor Kinase D8.811.913.696.620.682.700.150.125.500 D8.811.913.696.620.682.700.364. ... D6.472.699.631.525.600.505 gamma-Lipotropin D6.472.699.631.525.475.518 D6.472.699.631.525.600.518 gamma-MSH D6.472.699.631. ...
Ectopic production of lipotropin by cancer.. Odell WD; Wolfsen AR; Bachelot I; Hirose FM. Am J Med; 1979 Apr; 66(4):631-8. ... Radioimmunologic analysis of changes in the level of beta-2-microglobulin in cancer].. Zubovskiĭ LG; Polevaia EB; Kirsanov AG; ...
The major ingredients include: Progestins Prostaglandins Hydrolysed estrogens Hydroxyprogesterone Isoflavones Lipotropins What ... There are many natural steroids produced by various natural substances, such as, anabolic-androgenic steroids, beta-arrestins, ...
... beta Lactoglobulin G beta Lactoglobulin I,beta Lactoglobulin I beta Lipotropin C Fragment,beta Lipotropin C Fragment beta ... beta-Lactoglobulin G beta-Lactoglobulin I,beta-Lactoglobulin I beta-Lipotropin C Fragment,beta-Lipotropin C Fragment beta- ... beta-Endorphin Receptors beta-Globin delta,beta-Globin delta beta-Kallikrein B,beta-Kallikrein B beta-Lactoglobulin A,beta- ... Lipotropin 61 91 Lipotropin 61-91,Lipotropin 61-91 Lipotropin C Fragment,Lipotropin C Fragment Lipotropin Fragment C,Lipotropin ...
... beta Lactoglobulin G beta Lactoglobulin I,beta Lactoglobulin I beta Lipotropin C Fragment,beta Lipotropin C Fragment beta ... beta-Lactoglobulin G beta-Lactoglobulin I,beta-Lactoglobulin I beta-Lipotropin C Fragment,beta-Lipotropin C Fragment beta- ... beta-Endorphin Receptors beta-Globin delta,beta-Globin delta beta-Kallikrein B,beta-Kallikrein B beta-Lactoglobulin A,beta- ... Lipotropin 61 91 Lipotropin 61-91,Lipotropin 61-91 Lipotropin C Fragment,Lipotropin C Fragment Lipotropin Fragment C,Lipotropin ...
Plasma levels of beta-endorphin, adrenocorticotropic hormone and cortisol during early and late alcohol withdrawal. Alcohol and ... β-lipotropin (β-LPH), and β-endorphin. ACTH stimulates cells of the adrenal glands to produce and release the stress hormone ...
  • The anterior pituitary gland produces the pro-hormone POMC, which is then cleaved again to form adrenocorticotropin (ACTH) and β-lipotropin (β-LPH). (wikipedia.org)
  • For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, prompt the suprarenal cortex to release hormones. (medscape.com)
  • β-Lipotropin can be cleaved into smaller peptides. (wikipedia.org)
  • In sheep, gamma-lipotropic hormone is a 58-amino-acid long pituitary polypeptide formed from the first 58 residues of beta-lipotropic hormone. (wikipedia.org)
  • The carboxyl-terminal of gamma-lipotropic hormone is identical to the structure of beta-melanophore-stimulating hormone. (wikipedia.org)
  • Isolation and structural organization of the human corticotropin--beta-lipotropin precursor gene. (nih.gov)
  • A pituitary prohormone, Beta-lipotropin, is thought to be a precursor of both the endorphins and Beta-malanotropin. (nih.gov)
  • For example, in response to a stressful situation, the pituitary gland may release beta endorphin and ACTH, which, in turn, prompt the suprarenal cortex to release hormones. (medscape.com)
  • Endorphins are derived from the carboxy-terminal portion of Beta-lipotropin (residues 61-91) and Beta-melanotropin from residues 41-58. (nih.gov)