Serum Globulins
Sex Hormone-Binding Globulin
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
gamma-Globulins
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
Interleukin-1beta
Antilymphocyte Serum
Thyroxine-Binding Proteins
beta 2-Microglobulin
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
Thyroxine-Binding Globulin
Receptors, Adrenergic, beta
Integrin beta3
Rho(D) Immune Globulin
Seed Storage Proteins
Alpha-Globulins
Immunoglobulins, Intravenous
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Beta-Globulins
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Integrin alpha5beta1
Integrin beta4
Anemia, Aplastic
Integrin alpha6beta4
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Integrin beta Chains
Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.
beta 2-Glycoprotein I
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Integrin alpha4beta1
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Integrin alpha2beta1
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Receptors, Adrenergic, beta-2
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.
Immunoglobulins
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Gonadal Steroid Hormones
Cells, Cultured
Integrins
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Interleukin-1
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Antigens, CD29
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
Integrin alpha6beta1
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Thyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Receptors, Adrenergic, beta-1
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
Blood Proteins
Serum Albumin
Base Sequence
Progesterone-Binding Globulin
Integrin alpha1beta1
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Immune Sera
Iodine Isotopes
Immunization, Passive
Glycogen Synthase Kinase 3
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Estrogen Receptor beta
Estradiol
Rabbits
Transforming Growth Factor beta1
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Receptors, Adrenergic, beta-3
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Binding Sites
Radioimmunoassay
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Beta Rhythm
DNA Polymerase beta
Immunoglobulin G
Macromolecular Substances
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Dehydroepiandrosterone Sulfate
Cryoglobulins
Triiodothyronine
A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Gene Expression Regulation
Receptors, Transforming Growth Factor beta
Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.
Antigen-Antibody Reactions
Hypoproteinemia
Dose-Response Relationship, Drug
Transfection
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antibodies
Protein Subunits
Pregnancy
Propanolamines
Gene Expression
Electrophoresis, Polyacrylamide Gel
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Receptors, Vitronectin
Prolamins
Cloning, Molecular
Fibronectins
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
Peptide Fragments
Phosphorylation
Immunodiffusion
Cattle
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Mutation
Liver
beta Karyopherins
Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Cyclosporine
Amino Acid Sequence
Blotting, Western
Transplantation, Homologous
Phospholipase C beta
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Dihydrotestosterone
Sequence Homology, Amino Acid
Cricetinae
Immunosuppression
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Recombinant Fusion Proteins
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Antibody Formation
Graft Rejection
Ligands
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Adrenergic beta-Antagonists
Tumor Cells, Cultured
Androgens
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Antibodies, Anti-Idiotypic
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Estrone
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
Hepatocyte Nuclear Factor 3-beta
Horses
Transcription, Genetic
Models, Molecular
Integrin alphaVbeta3
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Seeds
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Immunohistochemistry
Serum Sickness
Protein Isoforms
DNA Primers
Insulin-Secreting Cells
Oxymetholone
Dialysis
Electrophoresis
Glycoproteins
Receptors, Nicotinic
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
Mice, Transgenic
Carrier Proteins
Hydrocortisone
Cell Membrane
Dehydroepiandrosterone
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Transplantation Conditioning
Hepatocyte Nuclear Factor 1-beta
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Postmenopause
Reverse Transcriptase Polymerase Chain Reaction
Rats, Sprague-Dawley
Precipitin Tests
Graft Survival
Chromatography, Gel
Polycystic Ovary Syndrome
A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Structure-Activity Relationship
Carbohydrate Sequence
Agammaglobulinemia
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Androgen-Binding Protein
Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Chorionic Gonadotropin, beta Subunit, Human
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
Binding, Competitive
Hyperthyroidism
Drug Therapy, Combination
Rh-Hr Blood-Group System
Bence Jones Protein
Protein Kinase C beta
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging roles in processes such as B-cell receptor regulation, oxidative stress-induced apoptosis, androgen receptor-dependent transcriptional regulation, insulin signaling, and endothelial cell proliferation.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Cell Movement
Albumins
Prealbumin
Complement System Proteins
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
DNA, Complementary
Soybeans
Antigens, CD18
Fibrinogen
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Enzyme Activation
Transforming Growth Factor beta2
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Isoenzymes
Haptens
Thyroid Hormones
Hypothyroidism
Vitamin D-Binding Protein
An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.
Caspase 1
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
Evidence for substrate-specific requirement of the splicing factor U2AF(35) and for its function after polypyrimidine tract recognition by U2AF(65). (1/222)
U2 snRNP auxiliary factor (U2AF) promotes U2 snRNP binding to pre-mRNAs and consists of two subunits of 65 and 35 kDa, U2AF(65) and U2AF(35). U2AF(65) binds to the polypyrimidine (Py) tract upstream from the 3' splice site and plays a key role in assisting U2 snRNP recruitment. It has been proposed that U2AF(35) facilitates U2AF(65) binding through a network of protein-protein interactions with other splicing factors, but the requirement and function of U2AF(35) remain controversial. Here we show that recombinant U2AF(65) is sufficient to activate the splicing of two constitutively spliced pre-mRNAs in extracts that were chromatographically depleted of U2AF. In contrast, U2AF(65), U2AF(35), and the interaction between them are required for splicing of an immunoglobulin micro; pre-RNA containing an intron with a weak Py tract and a purine-rich exonic splicing enhancer. Remarkably, splicing activation by U2AF(35) occurs without changes in U2AF(65) cross-linking to the Py tract. These results reveal substrate-specific requirements for U2AF(35) and a novel function for this factor in pre-mRNA splicing. (+info)Chromatin modification by DNA tracking. (2/222)
In general, the transcriptional competence of a chromatin domain is correlated with increased sensitivity to DNase I cleavage. A recent observation that actively transcribing RNA polymerase II piggybacks a histone acetyltranferase activity [Wittschieben, B., Otero, G., de Bizemont, T., Fellows, J., Erdjument-Bromage, H., Ohba, R., Li, Y., Allis, C. D., Tempst, P. & Svejstrup, J. Q. (1999) Mol. Cell 4, 123-128] implies that the state of histone acetylation, and hence the ability of chromatin to fold, can be altered by a processive mechanism. In this article, it is proposed that tracking-mediated chromatin modification could create and/or maintain an open configuration in a complete chromatin domain including both intra- and extragenic regions. This mechanism suggests a putative functional role for the extragenic transcription observed at the beta-globin and other loci in vertebrate cells. (+info)Globulins in protein supplements promote the development of preimplantation embryos. (3/222)
PURPOSE: Our purpose was to investigate the effect of alpha- and beta-globulins contained in protein supplements on the development of preimplantation embryos. METHODS: Mouse one-cell embryos were cultured in medium supplemented with 4 mg/ml human serum albumin (HSA), 4 mg/ml HSA plus human globulins (0.2, 0.4, 0.8, and 1.6 mg/ml) that consisted predominantly of alpha- and beta-globulins, or 10% Plasmanate Cutter (PC). Blastocysts developed in media supplemented with these various protein sources were stained with Hoechst 33342 to determine the number of cells. RESULTS: Supplementation with 0.4 to 1.6 mg/ml globulins or PC significantly increased the rate of blastocyst development compared with that observed with the addition of HSA. Supplementation with globulins significantly increased the hatching rate in a dose-dependent manner. The number of cells in the blastocysts was significantly increased when the embryos were cultured with 0.8 mg/ml of the globulins or PC. CONCLUSIONS: The present observations suggest that alpha- and beta-globulins in protein supplements promote embryo development and hatching. (+info)Influence of histochemical and immunohistochemical stains on polymerase chain reaction. (4/222)
The polymerase chain reaction (PCR) analysis of DNA extracted from tissue sections can be applied to a variety of research and diagnostic protocols. To analyze selectively the specific areas of tissue, a direct microdissection of histochemically or immunohistochemically stained sections, if satisfactory for PCR, is helpful. However, the influence of various staining methods on PCR has been poorly investigated. In this study, paraffin sections of formalin-fixed lymph node samples were histochemically stained with Mayer's hematoxylin, eosin Y, methyl green, or May-Grunwald solution and immunostained for CD45 using 3,3'-diaminobenzidine (DAB), DAB with cobalt ion (DAB-Co), or new fuchsin as the chromogen. In addition, unstained sections were treated with trypsin, microwave, or pressure cooker, the techniques frequently used in immunostains for antigen unmasking. DNA was extracted from each section, and the PCR efficiency in amplifying a 110 bp portion of the beta-globin gene was evaluated by two parameters: the cycle count in which the first visible band was obtained (CYCLE(min)) and the maximum amount of PCR products (CONC(max)). The hematoxylin stain showed a significantly prolonged CYCLE(min) (P < .01) and lower CONC(max) (P < .05) in comparison with unstained and untreated control sections. The May-Grunwald stain showed a prolonged CYCLE(min) (P < .01), although the CONC(max) was not significantly different from that of the control (P = .051). The eosin and methyl green stains showed no effects against PCR. In immunostains, the DAB-Co method showed a lower CONC(max) (P < .05), whereas the CYCLE(min) was not prolonged. The DAB and new fuchsin methods had no untoward effects. Antigen-unmasking treatments showed deteriorating effects on PCR. The trypsin treatment significantly prolonged the CYCLE(min) (P < .01), and the PCR amplification did not reach the "plateau" level with a maximum of 60 cycles. The PCR efficiency was worse in microwave or pressure cooker treatment, with neither CYCLE(min) nor CONC(max) being obtained. When target areas from sections for subsequent PCR amplification are microdissected, methyl green is most suitable as a dye for nuclear staining. The immunohistochemical visualization with DAB or new fuchsin yields no unfavorable effects. A successful PCR amplification may not be expected in sections that are pretreated in a microwave oven or pressure cooker. (+info)Suppression of metastasis by thymidine phosphorylase inhibitor. (5/222)
We developed a novel inhibitor of thymidine phosphorylase (TP), 5-chloro-6-[1-(2-iminopyrrolidinyl) methyl] uracil hydrochloride (TPI), that is about 1000-fold more active than 6-amino-5-chlorouracil, one of the most potent TP inhibitors. TPI inhibited the high chemotactic motility and basement membrane invasion of KB/TP cells, a TP-positive clone transfected with Rous sarcoma virus (RSV)/TP, to the levels seen in KB/CV cells, a control clone transfected with RSV. In nude mice, oral administration of TPI suppressed not only macroscopic liver metastases of highly metastatic KB/TP cells but also the level of human beta-globin as a molecular marker of micrometastases in the livers of the mice. These findings demonstrate that TP plays a key role in the invasiveness and metastasis of TP-expressing solid tumors and suggest that TPI might be a novel antimetastatic agent for blood-borne metastasis. (+info)Successful application of preimplantation genetic diagnosis for beta-thalassaemia and sickle cell anaemia in Italy. (6/222)
BACKGROUND: In Italy, the autosomal recessive diseases beta-thalassaemia and sickle cell anaemia are so widespread that in some regions they can be defined as 'social diseases'. In this study, nine clinical applications of preimplantation genetic diagnosis (PGD) were performed for beta-thalassaemia and sickle cell anaemia on seven Sicilian couples and carriers of beta-globin gene mutations. METHODS AND RESULTS: The studied mutations were: Cd39, HbS, IVS1 nt1, IVS1 nt6 and IVS1 nt110. ICSI was performed with partner's sperm on 131 out of 147 retrieved oocytes, and this resulted in 72 zygotes; 32 embryos were successfully biopsied on day 3. The biopsied blastomeres were lysed and the beta-globin alleles amplified by nested PCR. The mutation diagnosis was performed by restriction enzyme digestion and reverse dot-blot. The amplification efficacy was 97.2%. The genotype study of non-transferred and surplus embryos showed that the allele drop-out rate was 8.6%. Seventeen embryos were transferred in utero on day 4. All couples received an embryo transfer; of the four pregnancies obtained, three resulted in live births and one miscarried at 11 weeks. Prenatal diagnosis at the 11th week and miscarriage material analysis confirmed the PGD results. CONCLUSIONS: These studies represent the first successful application of PGD for beta-thalassaemia and sickle cell anaemia in Italy. (+info)Fluorescence PCR quantification of cyclin D1 expression. (7/222)
We have used a continuous fluorescence monitoring method to assess cyclin D1 mRNA expression in a variety of hematological and non-hematological processes. We examined 14 cell lines, 11 reactive lymphoid tissues, and 57 primary hematopoietic neoplasms including mantle cell lymphoma (MCL) (n = 10), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) (n = 11), acute lymphoblastic leukemia/lymphoma (n = 15), follicular lymphoma (n = 6), peripheral T-cell lymphoma (PTCL) (n = 3), anaplastic large cell lymphoma (n = 3), hairy cell leukemia (n = 3), Burkitt lymphoma (n = 1), Burkitt-like lymphoma (n = 4), and plasmacytoma (n = 1) for the expression of cyclin D1 mRNA using fluorescently labeled sequence-specific hybridization probes. Fluorescence (F) was plotted against cycle (C) number over 45 cycles. The log-linear portion of the F versus C graph identified a fractional cycle number for threshold fluorescence. A beta-globin mRNA transcript with equivalent amplification efficiency to that of cyclin D1 was used for assessment of RNA integrity and normalization. In general, the MCLs demonstrated substantially higher levels of cyclin D1 mRNA than the other lymphoproliferative processes. Moderately high levels of cyclin D1 mRNA were detected in one PTCL. On average, the CLL/SLL cases showed cyclin D1 mRNA levels two to three orders of magnitude lower than observed in the MCLs. Cell lines derived from non-hematopoietic neoplasms such as fibrosarcoma, small cell carcinoma, and neuroblastoma showed comparable or higher levels of cyclin D1 mRNA than the MCLs. Our results indicate that quantitative real-time reverse transcription (RT) polymerase chain reaction is a simple, rapid, and accurate technique for assessing cyclin D1 expression, and while it is not specific, it can reliably be used in the distinction of MCL from CLL/SLL. (+info)Y14 and hUpf3b form an NMD-activating complex. (8/222)
Messenger RNAs with premature translation termination codons (PTCs) are degraded by nonsense-mediated mRNA decay (NMD). In mammals, PTCs are discriminated from physiological stop codons by a process thought to involve the splicing-dependent deposition of an exon junction complex (EJC), EJC-mediated recruitment of Upf3, and Upf2 binding to the N terminus of Upf3. Here, we identify a conserved domain of hUpf3b that mediates an interaction with the EJC protein Y14. Tethered function analysis shows that the Y14/hUpf3b interaction is essential for NMD, while surprisingly the interaction between hUpf3b and hUpf2 is not. Nonetheless, hUpf2 is necessary for NMD mediated by tethered Y14. RNAi-induced knockdown and Y14 repletion of siRNA-treated cells implicates Y14 in the degradation of beta-globin NS39 mRNA and demonstrates that Y14 is required for NMD induced by tethered hUpf3b. These results uncover a direct role of Y14 in NMD and suggest an unexpected hierarchy in the assembly of NMD complexes. (+info)
Beta-globulins | Article about Beta-globulins by The Free Dictionary
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DETECTION OF ENHANCED INVIVO PLATELET ALPHA-GRANULE RELEASE IN DIFFERENT PATIENT GROUPS - COMPARISON OF BETA-THROMBOGLOBULIN,...
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Alteration within a discrete region of the H-2Ld alpha 1 helix...
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The Big C Taboo
Transferrin
Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds). *7S globulin family (seeds) ... The protein is composed of alpha helices and beta sheets that form two domains.[8] The N- and C- terminal sequences are ... In nephrotic syndrome, urinary loss of transferrin, along with other serum proteins such as thyroxine-binding globulin, ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ...
Antibody
Other globulins. *Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds) ... Chemical similarities to polypetide chains of myeloma globulins and normal gamma-globulins". J. Exp. Med. 116 (2): 207-227. doi ... Rho(D) immune globulin antibodies are specific for human RhD antigen.[67] Anti-RhD antibodies are administered as part of a ... Rho(D) Immune Globulin treatment prevents sensitization that can lead to Rh disease, but does not prevent or treat the ...
Albumin
Other globulins. *Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds) ...
Lactalbumin
Other globulins. *Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds) ... Beta-lactoglobulin. References[edit]. 1. Influence Of Dietary Lactalbumin Hydrolysate On The Immune System Of Mice And ... There are alpha and beta lactalbumins; both are contained in milk.. Scientific studies suggest that certain types of ...
Albumin
Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds). *7S globulin family (seeds) ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ...
Orosomucoid
Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds). *7S globulin family (seeds) ... plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ...
Edestin
... and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins and Gamma globulins) are long peptide-chains, precursors for ... "A haemoglobin-binding beta-globulin in human serum". Nature. 186 (4730): 1055-6. doi:10.1038/1861055b0. PMID 13838734. Kenneth ... Edestin is similar to serum globulin (blood plasma), and the biologically active protein of edestin is metabolized in the human ... it is much more efficient for the body to make globulins from locally digestible globular proteins. Edestin has the unique ...
Bernhard Cinader
Cinader, B.; Weitz, B. (1950-11-04). "Beta- and gamma-globulin tetanus antitoxin of the hyperimmune horse". Nature. 166 (4227 ...
Arne Tiselius
Putnam, F. W. (1993). "Alpha-, beta-, gamma-globulin-Arne Tiselius and the advent of electrophoresis". Perspectives in Biology ...
Antitelo
Beta globulini. noseći proteini: Seks hormon-vezujući globulin • Transferin. drugi: Angiostatin • Hemopeksin • Beta-2 ... gama globulin.. Kao što možemo da vidimo na grafikonu, gama globulin je najširi i razlog tome je što se gama globulin sastoji ... Antiadrenergici • Antihipertenzivi • Antihiperlipidemici (Statin, Fibrati, Sekvestranti žučne kiseline) • Beta-adrenergički ...
PAEP
"Serum levels of pregnancy-associated endometrial alpha 2-globulin (alpha 2-PEG), a glycosylated beta-lactoglobulin homologue, ... "Multiple forms of mRNA encoding human pregnancy-associated endometrial alpha 2-globulin, a beta-lactoglobulin homologue". ... bovine and buffalo beta-lactoglobulin. For example, there are 13 identities out of 22 possible matches with horse beta- ... Bell SC, Keyte JW, Waites GT (Nov 1987). "Pregnancy-associated endometrial alpha 2-globulin, the major secretory protein of the ...
DNA vaccine
... such as bovine growth hormone or rabbit beta-globulin polyadenylation sequences. Polycistronic vectors (ones located at ... An E. coli inner core and poly(beta-amino ester) outer coat function synergistically to increase efficiency by addressing ...
Globular protein
Other globular proteins are the alpha, beta and gamma (IgA, IgD, IgE, IgG and IgM) globulin. See protein electrophoresis for ... more information on the different globulins. Nearly all enzymes with major metabolic functions are globular in shape, as well ...
Hemoglobin
... it is stored as hemosiderin or ferritin in tissues and transported in plasma by beta globulins as transferrins. When the ... Globulin is metabolised into amino acids that are then released into circulation. Hemoglobin deficiency can be caused either by ... However, the level of Hb F can be elevated in persons with sickle-cell disease and beta-thalassemia. Variant forms that cause ... "HBB - Hemoglobin subunit beta - Pan paniscus (Pygmy chimpanzee) - HBB gene & protein". www.uniprot.org. Retrieved 2020-03-10. " ...
Serum protein electrophoresis
... alpha-1 globulins, alpha-2 globulins, beta 1 and 2 globulins, and gamma globulins. ... Beta zone[edit]. Transferrin and beta-lipoprotein (LDL) comprises the beta-1. Increased beta-1 protein due to the increased ... Beta-gamma interzone[edit]. C-reactive protein is found in between the beta and gamma zones producing beta/gamma fusion. IgA ... Alpha-2 - beta interzone[edit]. Cold insoluble globulin forms a band here which is not seen in plasma because it is ...
Machine perfusion
The result was a 45 g/l human albumin solution containing small amounts of gamma and beta globulins which was stable between 0 ... by extracting heat labile fibrinogen and gamma globulins from plasma to give a plasma protein fraction (PPF) solution. The ...
Hemoglobin
... it is stored as hemosiderin or ferritin in tissues and transported in plasma by beta globulins as transferrins. When the ... However, the level of Hb F can be elevated in persons with sickle-cell disease and beta-thalassemia. ... Globulin is metabolised into amino acids that are then released into circulation. ... Protein alignment of human hemoglobin proteins, alpha, beta, and delta subunits respectively. The alignments were created using ...
Androgen-binding protein
... (ABP) is a glycoprotein (beta-globulin) produced by the Sertoli cells in the seminiferous tubules of ... Sex hormone-binding globulin (SHBG) Bardin CW, Musto N, Gunsalus G, Kotite N, Cheng SL, Larrea F, Becker R (1981). " ... ABP has the same amino acid sequence as sex hormone-binding globulin (SHBG); the difference is the site of production and the ... the testis that binds specifically to testosterone (T), dihydrotestosterone (DHT), and 17-beta-estradiol. Because ABP binds to ...
Blood protein
Alpha-1-acid glycoprotein Alpha-1-fetoprotein alpha2-macroglobulin Gamma globulins Beta-2 microglobulin Haptoglobin ... Globulins make up 38% of blood proteins and transport ions, hormones, and lipids assisting in immune function. Fibrinogen ... All blood proteins are synthesized in liver except for the gamma globulins. Examples of specific blood proteins: Prealbumin ( ...
RASSF9
Beta-1-metal- binding globulin) RAB11A Ras-related protein Rab-11A GRCh38: Ensembl release 89: ENSG00000198774 - Ensembl, May ...
Serum protein electrophoresis
... alpha-1 globulins, alpha-2 globulins, beta 1 and 2 globulins, and gamma globulins. Proteins are separated by both electrical ... Transferrin and beta-lipoprotein (LDL) comprises the beta-1. Increased beta-1 protein due to the increased level of free ... resulting in a visible fibrinogen band between the beta and gamma globulins. C-reactive protein is found in between the beta ... Decreased beta-1 protein occurs in acute or chronic inflammation. Beta-2 comprises C3 (complement protein 3). It is raised in ...
Haemodialysis-associated amyloidosis
Use of high flux dialyzers Use of Beta 2 globulin absorber Preserve the residual kidney functions Early kidney transplant In ... September 1993). "beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis- ...
Alpha-1 antitrypsin
There are several clusters, the first being albumin, the second being the alpha, the third beta and the fourth gamma ( ... Alpha-1 antitrypsin is the main protein of the alpha-globulin 1 region. Another name used is alpha-1 proteinase inhibitor (α1- ... Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations ... immunoglobulins). The non-albumin proteins are referred to as globulins. The alpha region can be further divided into two sub- ...
Pharmacodynamics of estradiol
... follicle-stimulating hormone and sex-hormone-binding globulin during simultaneous vaginal administration of 17 beta-oestradiol ... Odlind V, Milsom I, Persson I, Victor A (June 2002). "Can changes in sex hormone binding globulin predict the risk of venous ... Lobo RA, Cassidenti DL (January 1992). "Pharmacokinetics of oral 17 beta-estradiol". J Reprod Med. 37 (1): 77-84. PMID 1548642 ... Estradiol increases the production and by extension circulating levels of sex hormone-binding globulin (SHBG), corticosteroid- ...
Beta globulin
Examples of beta globulins include: beta-2 microglobulin plasminogen angiostatins properdin sex hormone-binding globulin ... Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions ... "Examples of Protein Electrophoretograms" at ufl.edu Beta-globulins at the US National Library of Medicine Medical Subject ... than gamma globulins, but less mobile than alpha globulins. ...
Hemoglobin A
Beta-thalassemia (β-thalassemia) is an inherited mutation of the β-globulin gene which causes the reduced synthesis of the β- ... Hb S beta thalassemia is the least common and is experienced in patients who have inherited beta thalassemia hemoglobin from ... Fetuses have a non-alpha chain called gamma and after birth it is then called beta. The beta chain will pair with the alpha ... Hemoglobin A is the most common adult form of hemoglobin and exists as a tetramer containing two alpha subunits and two beta ...
Globulin
Alpha 1 globulins Alpha 2 globulins Beta globulins Gamma globulins (one group of gamma globulins is the immunoglobulins, which ... Globulins exist in various sizes. The lightest globulins are the alpha globulins, which typically have molecular weights of ... but are not globulins. All other serum globular proteins are globulins. All globulins fall into one of the following four ... Some globulins are produced in the liver, while others are made by the immune system. Globulins, albumins, and fibrinogen are ...
Index of biochemistry articles
... alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha-globulin - alpha-macroglobulin - alpha-MSH - Ames test - amide ... beta-2 microglobulin - beta adrenergic receptor - beta sheet - beta-1 adrenergic receptor - beta-2 adrenergic receptor - beta- ... transforming growth factor beta - transforming growth factor beta receptor - transient receptor potential - translation ( ... interferon-beta - interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 ...
Category:Blood proteins
Beta globulins. *Blood proteins. *Bovine serum albumin. C. *Cholesterylester transfer protein. *Conalbumin ...
Labormedizin
Alpha2-Globulin. 5,9…11,1 % Beta-Globulin. 7,9…13,9 % ...
Levothyroxine
Massive overdose can be associated with increased sympathetic activity and thus require treatment with beta-blockers.[18] ... Greater than 99% of circulating thyroid hormones are bound to plasma proteins including thyroxine-binding globulin, ...
Antiandrogen
Effects of the anti-androgen TSAA-291 (16 beta-ethyl-17 beta-hydroxy-4-oestren-3-one) on the secretion of gonadotrophins". Acta ... by decreasing free concentrations of androgens via increasing the hepatic production of sex hormone-binding globulin (SHBG) and ...
Tương
Globulins (proteins). *Beta-conglycinin. *Glycinin. PHAs (Lectins). *Soybean agglutinin (lectin). Enzymes. *Beta-amylase ...
Stuart-Prower-faktor - Wikipédia
Antihemofíliás globulin A (VIII) · Christmas-faktor (IX) · Stuart-Prower-faktor (X) · Rosenthal-faktor (XI) · Hageman-faktor ( ... evidence for identification of residue 63 as beta-hydroxyaspartic acid". Biochemistry 22 (12), 2875-84. o. DOI:10.1021/ ...
Globulin
Lipid-transporteerend Beta-Lipoproteine: Lipidtransport. *Transferrin: Iesentransport. *Fibrinogen: Vörstoop vun't Fibrin. * ... Vun „https://nds.wikipedia.org/w/index.php?title=Globulin&oldid=692670" ...
Index of HIV/AIDS-related articles
GAG - gamma globulin - gamma interferon - ganglion - GART - gastrointestinal (GI) - gene - gene therapy - genetic engineering ... beta-2 microglobulin (β2M) - bilirubin - bioavailability - biological response modifiers (BRMs) - biopsy - biotechnology - ... globulins - glycoprotein - gonorrhea - gp120 (gp120) - gp160 (gp160) - gp41 (gp41) - granulocyte - granulocyte macrophage- ...
Oat
3 linkages or beta-1, 4 linkages. This type of beta-glucan is also referred to as a mixed-linkage (1→3), (1→4)-beta-D-glucan. ... Oats are the only cereal containing a globulin or legume-like protein, avenalin, as the major (80%) storage protein.[18] ... Oat beta-glucan is a viscous polysaccharide made up of units of the monosaccharide D-glucose. Oat beta-glucan is composed of ... Beta-D-glucans, usually referred to as beta-glucans, comprise a class of indigestible polysaccharides widely found in nature in ...
Soy sauce
Globulins (proteins). *Beta-conglycinin. *Glycinin. PHAs (Lectins). *Soybean agglutinin (lectin). Enzymes. *Beta-amylase ...
Homeostasis
Blood sugar levels are regulated within fairly narrow limits.[33] In mammals the primary sensors for this are the beta cells of ... α-2-globulin called angiotensinogen. This decapeptide is known as angiotensin I.[51] It has no known biological activity. ... Here blood sugar regulation is unable to function because the beta cells of the pancreatic islets are destroyed and cannot ... the pancreatic islets.[34][35] The beta cells respond to a rise in the blood sugar level by secreting insulin into the blood, ...
Primary polydipsia
An example is polydipsia found in patients with autoimmune chronic hepatitis with severely elevated globulin levels. Evidence ... a sympatholytic beta blocker Vasopressin receptor antagonists, such as conivaptan Acetazolamide, a carbonic anhydrase inhibitor ...
Glutamate decarboxylase
Dalakas MC, Fujii M, Li M, Lutfi B, Kyhos J, McElroy B (December 2001). "High-dose intravenous immune globulin for stiff-person ... "Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons". PLOS One. 10 (2): e0117130 ...
Imunostimulator
Beta-glukan[12]. Literatura[uredi - уреди , uredi izvor]. *↑ Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis ... Anti-timocit globulin • Anti-limfocit globulin. -cept (Fuzija). CTLA-4 (Abatacept, Belatacept) • TNF inhibitor (Etanercept, ... vakcine (BCG vakcina, Melanoma vakcina) • beta-glukan (Lentinan) • Mifamurtid • tiazolidin (Pidotimod) • heterociklična ... Antiadrenergici • Antihipertenzivi • Antihiperlipidemici (Statin, Fibrati, Sekvestranti žučne kiseline) • Beta-adrenergički ...
Colostrum
... beta 1 and beta 2,[27][28] fibroblast growth factors,[29] epidermal growth factor,[30] granulocyte-macrophage-stimulating ... "Acceleration of the absorption of unchanged globulins in the new-born calf by factors in colostrum". J. Physiol. 160 (2): 234- ... "Transforming growth factor-beta (TGF-beta) in human milk". Clin. Exp. Immunol. 94 (1): 220-4. doi:10.1111/j.1365-2249.1993. ... Tokuyama Y, Tokuyama H (February 1993). "Purification and identification of TGF-beta 2-related growth factor from bovine ...
Steroidni hormon
Timus: Timozin (Timozin α1, Timozin beta) • Timopoietin • Timulin Organi za varenje: Želudac: gastrin • grelin • Duodenum: CCK ... poput seks hormon-vezujući globulin ili kortikosteroid-vezujući globulin. Dalje konverzije i katabolizam se odvijaju u jetri, ...
Smallpox
Patients in the early stage of disease showed a decrease in coagulation factors (e.g. platelets, prothrombin, and globulin) and ... Beta. *Human herpesvirus 6/Roseolovirus *Exanthema subitum. *Roseola vaccinia. *Cytomegalic inclusion disease ...
Gel electrophoresis of proteins
The globulins are classified by their banding pattern (with their main representatives): The alpha (α) band consists of two ... The beta (β) band - transferrin, LDL, complement The gamma (γ) band - immunoglobulin (IgA, IgD, IgE, IgG and IgM). Paraproteins ... Traditionally, two classes of blood proteins are considered: serum albumin and globulin. They are generally equal in proportion ...
Tofu skin
Globulins (proteins). *Beta-conglycinin. *Glycinin. PHAs (Lectins). *Soybean agglutinin (lectin). Enzymes. *Beta-amylase ...
Okara (food)
Globulins (proteins). *Beta-conglycinin. *Glycinin. PHAs (Lectins). *Soybean agglutinin (lectin). Enzymes. *Beta-amylase ...
Chickenpox
"Varizig™ as the Varicella Zoster Immune Globulin for the Prevention of Varicella In At-Risk Patients". Canada Communicable ... Beta. *Human herpesvirus 6/Roseolovirus *Exanthema subitum. *Roseola vaccinia. *Cytomegalic inclusion disease ... complications who have had significant exposure to the virus may be given intra-muscular varicella zoster immune globulin (VZIG ...
Diethylstilbestrol
... interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma". J. Clin. ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta" ... The distribution half-life of DES is 80 minutes.[1] It has no affinity for SHBG or corticosteroid-binding globulin, and hence ... it stimulates hepatic sex hormone-binding globulin (SHBG) production, thereby increasing circulating levels of SHBG and ...
Norethisterone
... to 3-fold increase in sex hormone-binding globulin (SHBG) levels and a consequent decrease in free testosterone levels caused ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ...
Soybean
Peanuts, for instance, contain 20% 2S albumin but only 6% 7S globulin and 74% 11S.[35] It is the high 2S albumin and low 7S ... Beta-carotene (μg) 97 0 5 1 8 0 8,509 83 0 457 10,500 ... Shutov, A.D. (2011). "Evolution of seed storage globulins and ... All spermatophytes, except for the grass-cereal family, contain 7S (vicilin) and 11S (legumin) soy protein-like globulin ... contains the 7S globulin, which contributes to cocoa/chocolate taste and aroma;,[29][30][31] whereas coffee beans (coffee ...
Interferon tip I - Википедија, слободна енциклопедија
Todd and Naylor, New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and ... Anti-timocit globulin • Anti-limfocit globulin. -cept (Fuzija). CTLA-4 (Abatacept, Belatacept) • TNF inhibitor (Etanercept, ...
Cladribine
In the mid-1990s Beutler, in collaboration with Jack Sipe, a neurologist at Scripps, ran several clinical trials exploring the utility of cladribine in multiple sclerosis, based on the drug's immunosuppressive effects. Sipe's insight into MS, and Beutler's interest in MS due to his sister having it, led a very productive collaboration.[18]:17[22] Ortho-Clinical, a subsidiary of J&J, filed an NDA for cladribine for MS in 1997 but withdrew it in the late 1990s after discussion with the FDA proved that more clinical data would be needed.[23][24] Ivax acquired the rights for oral administration of cladribine to treat MS from Scripps in 2000,[25] and partnered with Serono in 2002.[24] Ivax was acquired by Teva in 2006,[26][27] and Merck KGaA acquired control of Serono's drug business in 2006.[28] An oral formulation of the drug with cyclodextrin was developed[29]:16 and Ivax and Serono, and then Merck KGaA conducted several clinical studies. Merck KGaA submitted an application to the European ...
WHO Model List of Essential Medicines
the square box applies to epoetin alfa, beta and theta, darbepoetin alfa, methoxy polyethylene glycol-epoetin beta,and their ... Rho(D) immune globulin (anti-D immunoglobulin). *Anti-rabies immunoglobulin. *Anti-tetanus immunoglobulin ...
Beta globulin - Wikipedia
Examples of beta globulins include: beta-2 microglobulin plasminogen angiostatins properdin sex hormone-binding globulin ... Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions ... "Examples of Protein Electrophoretograms" at ufl.edu Beta-globulins at the US National Library of Medicine Medical Subject ... than gamma globulins, but less mobile than alpha globulins. ...
Viral Pneumonia Medication: Antiviral agents, Monoclonal Antibodies, Immune Globulins, Beta-Agonists
Beta-Agonists. Class Summary. Many patients with viral pneumonia have bronchospasm, which is relieved or improved with the use ... Immune Globulins. Class Summary. High-dose intravenous immunoglobulin has been used successfully in conjunction with ... Albuterol is a beta-agonist used to treat bronchospasm. It relaxes bronchial smooth muscle with its action on beta2-receptors. ... Immune globulin IV (Gamimune, Gammagard, Sandoglobulin, Gammar-P). *View full drug information ...
Beta globulin dictionary definition | beta globulin defined
... separation of serum proteins migrate faster toward the anode than gamma globulins but more slowly than alpha globulins. Beta ... nounAny of a group of globulins in blood plasma that in an electrophoretic ... beta globulin. beta globulin. noun. Any of a group of globulins in blood plasma that in an electrophoretic separation of serum ... "beta globulin." YourDictionary, n.d. Web. 17 August 2018. ,http://www.yourdictionary.com/beta-globulin,. ...
Beta Globulin of Amniotic Fluid - Cancer Council Victoria
Beta globulin | Article about beta globulin by The Free Dictionary
Find out information about beta globulin. A heterogeneous fraction of serum globulins containing transferrin and various ... Related to beta globulin: gamma globulin, alpha globulin, albumin. beta globulin. [′bād·ə ′gläb·yə·lən] (biochemistry) A ... Beta globulin , Article about beta globulin by The Free Dictionary https://encyclopedia2.thefreedictionary.com/beta+globulin ... The alpha and beta globulins are synthesized exclusively in the liver.. Blood pressure, alkaline phosphatase, serum globulin, A ...
beta-2 micro globulin - News & Blog - John Douglas French Alzheimer's Foundation
Total Protein Electrophoresis | Cornell University College of Veterinary Medicine
... into the component albumin and globulins. Electrophoresis is indicated for determination of the underlying nature of a ... Beta (b) globulins These migrate between g- and a-globulins. They are usually produced in the liver and include fibrinogen ( ... There are three globulin fractions: alpha, beta and gamma. Total protein This is measured on the Modular P using the biuret ... Like a-globulins, b-globulins can be divided into two major components (b1 and b2) in most species, although further ...
ESTIMATION OF THE SERUM BETA1C GLOBULIN CONCENTRATION: ITS RELATION TO THE SERUM HEMOLYTIC COMPLEMENT TITER | American Academy...
The depression of a single serum protein, the beta1C globulin (normally 130-155 mg/ 100 ml) to below 80 mg/100 ml is manifested ... ESTIMATION OF THE SERUM BETA1C GLOBULIN CONCENTRATION: ITS RELATION TO THE SERUM HEMOLYTIC COMPLEMENT TITER. Martin R. ... ESTIMATION OF THE SERUM BETA1C GLOBULIN CONCENTRATION: ITS RELATION TO THE SERUM HEMOLYTIC COMPLEMENT TITER ... ESTIMATION OF THE SERUM BETA1C GLOBULIN CONCENTRATION: ITS RELATION TO THE SERUM HEMOLYTIC COMPLEMENT TITER ...
Beta-globulins | Article about Beta-globulins by The Free Dictionary
Find out information about Beta-globulins. any of a large family of proteins protein, any of the group of highly complex ... organic compounds found in all living cells and comprising the most abundant... Explanation of Beta-globulins ... Beta-globulins , Article about Beta-globulins by The Free Dictionary https://encyclopedia2.thefreedictionary.com/Beta-globulins ... globulin. (redirected from Beta-globulins). Also found in: Dictionary, Thesaurus, Medical. globulin,. any of a large family of ...
Transferrin - Wikipedia
Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds). *7S globulin family (seeds) ... The protein is composed of alpha helices and beta sheets that form two domains.[8] The N- and C- terminal sequences are ... In nephrotic syndrome, urinary loss of transferrin, along with other serum proteins such as thyroxine-binding globulin, ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ...
Antibody - Wikipedia
Other globulins. *Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. *Alpha-lactalbumin. *11S globulin family (seeds) ... Chemical similarities to polypetide chains of myeloma globulins and normal gamma-globulins". J. Exp. Med. 116 (2): 207-227. doi ... Rho(D) immune globulin antibodies are specific for human RhD antigen.[67] Anti-RhD antibodies are administered as part of a ... Rho(D) Immune Globulin treatment prevents sensitization that can lead to Rh disease, but does not prevent or treat the ...
Globulin the serum protein and groups of globulin alpha beta and gamma globulins | High Globulin
Globulin is vital for the normal function of the human body and its tissues and organs. ... Globulin is one of three serum proteins found in the blood. The others are fibrinogen and albumin. ... However, there are four different groups of globulin; these are alpha-1, alpha-2, beta, and gamma globulins, so the medic must ... All about High Globulin Levels the side effects of Gamma Globulin and Infusions of gamma globulin. ...
Patent US7848487 - Methods for sterilizing biological materials containing non-aqueous solvents - Google Patents
... alpha-globulins; beta-globulins; gamma-globulins; coagulation proteins; complement proteins; and interferons. ... Dried, sterilized, gamma-globulin-fixed column and a process for preparing the same. ... Preparation of intravenous human and animal gamma globulins and isolation of albumin. ... globulins, such as immunoglobulins IgA, IgM, IgG and IgE; and the like. A preferred group of blood proteins includes Factor I ( ...
globulin | biochemistry | Britannica.com
globulin: One of the major classifications of proteins, which may be further divided into the euglobulins and the ... Three types of globulin have been identified-alpha, beta, and gamma. Alpha and beta globulins are transport proteins, serve as ... Three types of globulin-alpha, beta, and gamma-have been identified; alpha and beta globulins are transport proteins and serve ... Globulins are an important source of protein in seed plants and are found in minute amounts in cereals. Globulins found in ...
Various factors affecting /sup 67/Ga scintigraphy of liver cancer (Journal Article) | ETDEWEB
Beta-globulin test serum proteins electrophoresis alpha1 alpha2-globulins serum Amino acids enzymes hormones osmotic pressure...
This subgroup of globulins is divided into faster and slower alpha1 and alpha2-globulins.Proteins are the most abundant ... Alpha globulins are serum proteins that have the most rapid migration during electrophoresis. ... There are four major groups that can be identified: gamma globulins, beta globulins, alpha-2 globulins, and alpha-1 globulins. ... but less mobile than alpha globulins. Examples of beta globulins include: ·. beta-2 microglobulin ...
Serum globulin electrophoresis: MedlinePlus Medical Encyclopedia
The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. ... Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulins include various types of ... The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. ... This test is done to look at globulin proteins in the blood. Identifying the types of globulins can help diagnose certain ...
High Elevated B12 and Folate, Low Iron and Globulin - Gastroenterology - MedHelp
And, my Alpha 2 and Beta globulins are low now. Any feedback??? ... And, my Alpha 2 and Beta globulins are low now. Any feedback ... High Elevated B12 and Folate, Low Iron and Globulin. Hi, I am 7 months out from having a transduodenal sphincteroplasty where ... The iron/ ferritin and globulin levels could be related to low dietary intake/ malsorption or secondary to a few systemic ... The iron/ ferritin and globulin levels could be related to low dietary intake/ malsorption or secondary to a few systemic ...
Sex hormone-binding globulin - wikidoc
Latent TGF-beta binding protein. *Major urinary proteins. *Membrane transport protein. *Odorant binding protein ... Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and ... Testosterone-estradiol binding globulin (TeBG, TEBG). References. *↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 ... interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma". J. Clin. ...
Respiratory syncytial virus immune globulin intravenous - definition of respiratory syncytial virus immune globulin intravenous...
respiratory syncytial virus immune globulin intravenous synonyms, respiratory syncytial virus immune globulin intravenous ... English dictionary definition of respiratory syncytial virus immune globulin intravenous. n. 1. Any of a class of proteins that ... pronunciation, respiratory syncytial virus immune globulin intravenous translation, ... Blood serum globulins are divided into several groups, including the alpha, beta, and gamma globulins. ...
Phosphorus /certified fixed orthodontic courses by Indian dental acad…
CFH gene: MedlinePlus Genetics
Low serum globulin levels - Things You Didn't Know
Parola on low serum globulin levels: Must get on a higher dose of synthroid (thyroxine). This can be life threatening, get ... Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes? ... Total protein 8.3, serum albumin 4.2 , serum globulin 3.8, albumin globulin ratio 1.2.. Is this abnormal? ... Globulins are other proteins usually made to fight diseases like infections- perhaps youve been fighting an illness for a few ...
TPLC - Total Product Life Cycle
lab assessment Flashcards by Andrea Janney | Brainscape
Effects of Functional Incidental Training in VA NHCU Residents
Total Protein and Albumin/Globulin (A/G) Ratio
A calculated ratio of albumin to globulins (A/G ratio) may also be reported. ... These proteins are larger than albumin and are divided into alpha, beta and gamma globulins. ... The remaining 40% of proteins in the plasma are referred to as globulins. The globulin proteins are a varied group. They ... Globulins are all the proteins in the blood other than albumin, and this group is comprised of hundreds of different types. ...
ת?? (TF) ELISA Kit,Apotransferrin ELISA Kit; Beta 1 metal binding globulin ELISA Kit; Beta-1 metal-binding globulin ELISA...
Beta-1 metal-binding globulin ELISA Kit; DKFZp781D0156 ELISA Kit; PRO1400 ELISA Kit; PRO1557 ELISA Kit; PRO2086 ELISA Kit; ... Ϊ???? ??ת?? (TF) ELISA Kit,Apotransferrin ELISA Kit; Beta 1 metal binding globulin ELISA Kit; ... Apotransferrin ELISA Kit; Beta 1 metal binding globulin ELISA Kit; Beta-1 metal-binding globulin ELISA Kit; DKFZp781D0156 ELISA ... TGF-beta signaling pathway Wnt signaling pathway view all pathways ...
Structural stability of beta-globulin, the low molecular weight protein fraction from sesame seed (Sesamum indicum L.) in...
Beta-globulin, a single polypeptide chain of molecular weight 15,000 +/- 1,000, undergoes denaturation in alkaline pH (7.0-13.0 ... Structural stability of beta-globulin, the low molecular weight protein fraction from sesame seed (Sesamum indicum L.) in ... Structural stability of beta-globulin, the low molecular weight protein fraction from sesa ...
CFR - Code of Federal Regulations Title 21
866.5160 Beta-globulin immunological test system. (a) Identification. A beta -globulin immunological test system is a device ... Beta -globulin proteins include beta -lipoprotein, transferrin, glycoproteins, and complement, and are rarely associated with ... that consists of reagents used to measure by immunochemical techniques beta globulins (serum protein) in serum and other body ...
TransferrinElectrophoresisImmunoglobulinsFractionsFibrinogenHormone-bindingAntibodiesLiverAlbumin and globulinsTypes of globulinsCold insolublTotal proteinRatioAntithymocyte globulinImmunologicalHigh globulinGlobularAntibodyAlpha-lactalbuminAlkalineAcquired immunityInfectionAmmonium sulfateDiluteAcute phase reHyperimmuneHeterogeneousHuman serumPrealbuminSerum betaBlood proteinsFerritinProteins calledGlycoproteinDiseasesElectrophoreticImmune systemAmountsTransport proteinsPreparationsLevelsLipids
Transferrin4
- Beta globulins include transferrin and other transport proteins. (yourdictionary.com)
- A heterogeneous fraction of serum globulins containing transferrin and various complement components. (thefreedictionary.com)
- Beta -globulin proteins include beta -lipoprotein, transferrin, glycoproteins, and complement, and are rarely associated with specific pathologic disorders. (fda.gov)
- Examples are transferrin, a beta 1 -globulin that transports iron, and alpha 1 -antitrypsin, an acute phase reactant that inhibits serum proteases. (thefreedictionary.com)
Electrophoresis8
- The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). (thefreedictionary.com)
- Thus the α 2 -globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α 2 -macroglobulin), each with differing functions. (thefreedictionary.com)
- The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. (medlineplus.gov)
- The specific profile of the globulins is determined by protein electrophoresis (SPEP), which separates the proteins according to size and charge. (smrtx.com)
- The plasma globulins are separated into five fractions by serum protein electrophoresis (SPE). (thefreedictionary.com)
- Serum globulin can be separated into several subgroups by serum protein electrophoresis. (ispub.com)
- Serum protein electrophoresis (SPE) is an analytical technique that provides separation of serum protein into six fractions: Albumin, Alpha-1, Alpha-2, Beta-1, Beta-2 and Gamma. (specialtylabs.com)
- The pattern of serum protein electrophoresis results depends on the fractions of two major types of protein: albumin and globulins. (aafp.org)
Immunoglobulins4
- Gamma globulins include various types of antibodies such as immunoglobulins (Ig) M, G, and A. (medlineplus.gov)
- the immune system produces gamma globulins, also called immunoglobulins and antibodies. (films.com)
- Edestin is similar to serum globulin (blood plasma), and the biologically active protein of edestin is metabolized in the human body and capable of biosynthesizing: hormones (which regulate all the body processes), hemoglobin (which transports oxygen, carbon dioxide, and nitric oxide), enzymes (which catalyze and control biochemical reactions), antibodies (immunoglobulins which fend off invading bacteria, viruses, and other pathogens, as well as toxins or antigens as they enter the body). (wikipedia.org)
- Treatment for a whole year seems surprising even if your immunoglobulins (gamma globulin) are low. (healthtap.com)
Fractions4
- 3,5,6) The alpha-1, alpha-2, and beta globulin fractions of the EPH contain most of the acute-phase proteins, including fibrinogen and serum amyloid A, whereas the gamma fraction contains antibodies to viral, bacterial, or fungal pathogens. (thefreedictionary.com)
- There are three globulin fractions: alpha, beta and gamma. (cornell.edu)
- Antibodies are produced by mature B lymphocytes called plasma cells, while most of the other proteins in the alpha and beta fractions are made in the liver. (smrtx.com)
- In order of decreasing electrophoretic mobility these fractions are the alpha 1 -, alpha 2 -, beta 1 -, and beta 2 -globulins, and the gamma globulins. (thefreedictionary.com)
Fibrinogen1
- The aim of the method described here is to remove hemoglobin, the major contaminant in the bovine plasma obtained from slaughterhouses, by adding a mixture of 19% cold ethanol and 0.6% chloroform, followed by fibrinogen and globulin precipitation by the Cohn method and nonspecific hemagglutinin by thermocoagulation. (scielo.br)
Hormone-binding3
- Sex hormone-binding globulin ( SHBG ) or sex steroid-binding globulin ( SSBG ) is a glycoprotein that binds to androgens and estrogens . (wikidoc.org)
- Sex hormone-binding globulin is homodimeric, meaning it has two identical peptide chains making up its structure. (wikidoc.org)
- SHBG (Sex Hormone-binding Globulin), also known as ABP (Androgen-binding Protein), is a variably glycosylated, secreted, non-disulfide-linked homodimer. (rndsystems.com)
Antibodies5
- Globulins found in animal fluids are enzymes, antibodies, and fibrous and contractile proteins usually contained in the blood plasma . (britannica.com)
- In humans and many of the other mammals, antibodies, when they are formed, occur in the gamma globulins. (britannica.com)
- Globulins are proteins that include gamma globulins (antibodies) and a variety of enzymes and carrier/transport proteins. (smrtx.com)
- The initial increase in gamma globulins closely paralleled the appearance of antibodies. (ajtmh.org)
- hyperimmune globulin any of various immune globulin preparations especially high in antibodies against certain specific diseases. (thefreedictionary.com)
Liver3
- The alpha and beta globulins are synthesized exclusively in the liver. (thefreedictionary.com)
- If a test finds abnormally high globulin levels, this could be an indicator of the following diseases: rheumatoid arthritis, leukaemia, various chronic inflammatory diseases (e.g. syphilis and tuberculosis), liver diseases such as cirrhosis and jaundice, ulcerative colitis, various autoimmune disorders, plus chronic viral and bacterial infections (e.g. hepatitis and HIV). (high-globulin.com)
- Some globulins are made by the liver, while others are made by the immune system. (ispub.com)
Albumin and globulins4
- This procedure separates the proteins in serum and body fluids (e.g. peritoneal fluid, urine) into the component albumin and globulins. (cornell.edu)
- The electrophoretogram splits the protein fraction of serum or plasma into its constituent components this includes albumin and globulins. (cornell.edu)
- The major measured serum proteins are divided into two groups, albumin and globulins. (smrtx.com)
- Because the total protein represents the sum of albumin and globulins, it is more important to know which protein fraction is high or low than what is the total protein. (smrtx.com)
Types of globulins2
- Identifying the types of globulins can help diagnose certain medical problems. (medlineplus.gov)
- There are four major types of globulins, each with specific properties and actions. (smrtx.com)
Cold insolubl1
- The insoluble form that was formerly called cold-insoluble globulin is a large complex of cross-linked subunits. (bionity.com)
Total protein7
- A typical blood panel will provide four different measurements - the total protein, albumin, globulins, and the albumin globulin ratio. (smrtx.com)
- low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry? (healthtap.com)
- Some laboratories report total protein, albumin, and the calculated ratio of albumin to globulins, termed the A/G ratio. (labtestsonline.org)
- The A/G ratio is calculated from measured total protein, measured albumin, and calculated globulin (total protein - albumin). (labtestsonline.org)
- Additionally, since total protein can be low, increased, or the component globulin proteins altered with many different diseases and disorders, total protein and albumin tests may be ordered in a variety of settings to help diagnose disease, to monitor changes in health status, and as a screen that may indicate the need for various follow-up tests. (labcorp.com)
- A test for total serum protein reports separate values for total protein, albumin, and globulin. (ispub.com)
- A total serum protein test is a blood test that measures the amounts of total protein , albumin, and globulin in the blood. (cigna.com)
Ratio6
- What causes high globulin, but low globulin albumin ratio? (healthtap.com)
- Normally, there is a little more albumin than globulins, giving a normal A/G ratio of slightly over 1. (labcorp.com)
- Because disease states affect the relative amounts of albumin and globulin, the A/G ratio may provide a clue as to the cause of the change in protein levels. (labcorp.com)
- The amounts of albumin and globulin also are compared (albumin/globulin ratio). (ispub.com)
- Normally, there is a little more albumin than globulin and the ratio is greater than 1. (ispub.com)
- After adjusting for sex and age as confounding factors, only beta globulin was found to be associated with Coats' disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0-3.1, P =0.02). (dovepress.com)
Antithymocyte globulin3
- Antithymocyte globulin (e.g. (clinicaltrials.gov)
- The START trial aims to determine whether antithymocyte globulin (ATG) treatment can halt the progression of newly diagnosed type 1 diabetes when given within 12 weeks of disease diagnosis. (clinicaltrials.gov)
- The medication being tested in the START trial is antithymocyte globulin (e.g. (clinicaltrials.gov)
Immunological2
High globulin1
- All about High Globulin Levels the side effects of Gamma Globulin and Infusions of gamma globulin. (high-globulin.com)
Globular5
- Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions than gamma globulins, but less mobile than alpha globulins. (wikipedia.org)
- When speaking of globulin, the term globular protein is sometimes used, but it should be noted that albumin is another form of globular protein, so it is important to understand that globulin and globular protein are not interchangeable terms. (high-globulin.com)
- Though the human body can manufacture globular proteins from any protein source, it is much more efficient for the body to make globulins from locally digestible globular proteins. (wikipedia.org)
- Globular proteins found in edestin (and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins and Gamma globulins) are long peptide-chains, precursors for biological proteins essential for life. (wikipedia.org)
- And globulins along with albumins are classified as globular proteins. (globalhemp.com)
Antibody2
- Since the gamma fraction usually makes up the largest portion of the globulins, antibody deficiency should always come to mind when the globulin level is low. (smrtx.com)
- However, later in the course of the infections there appeared to be little correlation between the gamma globulin and antibody levels. (ajtmh.org)
Alpha-lactalbumin1
- Ideally, whey protein is a mixture of beta-lacto globulin, alpha-lactalbumin, bovine serum albumin, immunoglobins and Glycomacropeptide. (amazonaws.com)
Alkaline2
- Structural stability of beta-globulin, the low molecular weight protein fraction from sesame seed (Sesamum indicum L.) in alkaline solution. (bvsalud.org)
- Beta-globulin , a single polypeptide chain of molecular weight 15,000 +/- 1,000, undergoes denaturation in alkaline pH (7.0-13.0), thereby affecting the hydrodynamic properties of the protein , viz. (bvsalud.org)
Acquired immunity1
- Gamma globulins have a vital role in natural and acquired immunity to infection. (britannica.com)
Infection1
- Other globulins transport metals, such as iron, in the blood and help fight infection. (ispub.com)
Ammonium sulfate1
- On the other hand, globulins are salted out (i.e., precipitated) by half-saturation with ammonium sulfate. (britannica.com)
Dilute1
- The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. (thefreedictionary.com)
Acute phase re1
- There is an increase in a-2 globulins (arrowhead), indicating an acute phase reactant response, and a polyclonal gammopathy (arrow). (cornell.edu)
Hyperimmune1
- Hyperimmune globulin is used primarily for passive immunization in some viral illnesses. (medscape.com)
Heterogeneous1
- In fact, the globulins are a heterogeneous array of proteins of widely varying structure and function, only a few of which will be mentioned here. (britannica.com)
Human serum1
- immune human serum globulin immune globulin (def. (thefreedictionary.com)
Prealbumin1
- All plasma proteins except albumin and prealbumin are globulins. (thefreedictionary.com)
Serum beta3
- A rapid immunoassay of the serum beta 1C globulin can be easily performed. (aappublications.org)
- The Increase of Thyroid Abnormalities, Elevated Serum Beta Globulins and Type A Blood Group in Paget's Disease. (annals.org)
- Serum beta globulin levels appear to be elevated in patients with Coats' disease. (dovepress.com)
Blood proteins2
- [4] They constitute most of the gamma globulin fraction of the blood proteins . (wikipedia.org)
- subgroup of the blood proteins called globulins. (britannica.com)
Ferritin1
- The iron/ ferritin and globulin levels could be related to low dietary intake/ malsorption or secondary to a few systemic causes. (medhelp.org)
Proteins called1
- Globulin is made up of different proteins called alpha, beta, and gamma types. (ispub.com)
Glycoprotein1
- Complement factor H (CFH), originally known as beta-1H globulin, is a serum glycoprotein that regulates the function of the alternative complement pathway in fluid phase and on cellular surfaces. (abcam.com)
Diseases3
- When testing for the possibility of quite a large number of different diseases and disorders, establishing globulin levels is an important part of a doctor's diagnosis. (high-globulin.com)
- On the other hand, low globulin levels could ring a different set of alarm bells, being a possible indicator of things like celiac disease, irritable bowel syndrome, anaemia, and some kidney diseases. (high-globulin.com)
- Globulins are other proteins usually made to fight diseases like infections- perhaps you've been fighting an illness for a few weeks/months that explain this pattern. (healthtap.com)
Electrophoretic1
- Any of a group of globulins in blood plasma that in an electrophoretic separation of serum proteins migrate faster toward the anode than gamma globulins but more slowly than alpha globulins. (yourdictionary.com)
Immune system2
- The research teams found that a blood-borne molecule (beta-2 microglobulin, or B2M, a component of a larger molecule called MHC) which plays an important role in the adaptive immune system, greatly increases as we age, and can act adversely in the brain , in ways not related to immunity-blocking the regeneration of brain cells, thus promoting cognitive decline . (jdfaf.org)
- Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells in the pancreas. (clinicaltrials.gov)
Amounts2
- Globulins are an important source of protein in seed plants and are found in minute amounts in cereals. (britannica.com)
- It also measures the amounts of two major groups of proteins in the blood: albumin and globulin. (ispub.com)
Transport proteins1
- Alpha and beta globulins are transport proteins, serve as substrates upon which other substances are formed, and perform other diverse functions. (britannica.com)
Preparations1
- There are different reasons why globulin levels may become raised, but it should be noted that meddling with things like anabolic steroids, preparations containing Human Growth Hormone (HGH), and progesterone may all have the effect of raising levels of globulin in the blood. (high-globulin.com)
Levels5
- these are alpha-1, alpha-2, beta, and gamma globulins, so the medic must identify which of these, if any, has abnormal levels, which in turn might point to an underlying problem. (high-globulin.com)
- It is also known that elevated levels of oestrogen and extended use of oral contraceptives may both have an impact on globulin levels. (high-globulin.com)
- You can bet that testing for globulin levels is one guaranteed way that the doctor can get to the bottom of what is ailing you and so you should set up a consultation as a matter of urgency. (high-globulin.com)
- Elevated gamma globulin levels tended to persist if clinical evidence of immunity was present but decreased rapidly to normal levels if evidence of immunity was lacking. (ajtmh.org)
- In general, alpha and gamma globulin protein levels increase when there is inflammation in the body. (ucsfhealth.org)
Lipids1
- Other globulins are involved in the transport of a variety of substances, including lipids lipids, a broad class of organic products found in living systems. (thefreedictionary.com)