beta-Endorphin
Endorphins
One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.
beta-Lipotropin
A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Melanocyte-Stimulating Hormones
Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS OF HYPOTHALAMUS.
Pituitary Hormones, Anterior
Pro-Opiomelanocortin
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
N-Terminal Acetyltransferases
Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study. (1/492)
OBJECTIVES: The purpose of this study was to test whether cutaneous thermal pain thresholds are related to anginal pain perception. BACKGROUND: Few ischemic episodes are associated with angina; symptoms have been related to pain perception thresholds. METHODS: A total of 196 patients with documented coronary artery disease underwent bicycle exercise testing and thermal pain testing. The Marstock test of cutaneous sensory perception was administered at baseline after 30 min of rest on two days and after exercise and mental stress. Resting hot pain thresholds (HPTs) were averaged for the two baseline visits and divided into two groups: 1) average HPT <41 degrees C, and 2) average HPT > or =41 degrees C, to be clearly indicative of abnormal hypersensitivity to noxious heat. RESULTS: Patients with HPT <41 degrees C had significantly shorter time to angina onset on exercise testing than patients with HPT > or =41 degrees C (p < 0.04, log-rank test). Heart rates, systolic blood pressure and rate-pressure product at peak exercise were not different for the two groups. Resting plasma beta-endorphin levels were significantly higher in the HPT <41 degrees C group (5.9+/-3.7 pmol/liter vs. 4.7+/-2.8 pmol/liter, p = 0.02). Using a Cox proportional hazards model, patients with HPT <41 degrees C had an increased risk of angina (p = 0.03, rate ratio = 2.0). These differences persisted after adjustment for age, gender, depression, anxiety and history of diabetes or hypertension (p < 0.01). CONCLUSIONS: Occurrence of angina and timing of angina onset on an exercise test are related to overall hot pain sensory perception. The mechanism of this relationship requires further study. (+info)Enhancing effects of beta-endorphin on glutamate neurotoxicity. (2/492)
AIM: To study the effect of beta-endorphin (beta-End) on monosodium glutamate (MSG)-induced neurotoxicity (GNT). METHODS: Image analysis of neuronal areas and determination of mitochondrial membrane protein-bound Ca2+ and intracellular free Ca2+ ([Ca2+]i) were used. RESULTS: beta-End aggravated MSG-induced neuronal injury in arcuate nucleus of hypothalamus in a dose-dependent manner in the range from 0.5 to 5.0 mg.kg-1. MSG-induced increase in mitochondrial membrane protein-bound Ca2+ was enhanced when treated with beta-End 2 g.L-1. MSG-induced elevation in [Ca2+]i in single neuron was also augmented from 320 +/- 84 to 589 +/- 78 nmol.L-1 by the treatment with beta-End 2 g.L-1. CONCLUSION: beta-End enhanced GNT via aggravating the disruption of intracellular Ca2+ homeostasis induced by MSG. (+info)Physiological changes in Pachinko players; beta-endorphin, catecholamines, immune system substances and heart rate. (3/492)
Pachinko is a popular form of recreation in Japan. However, in recent years, along with Pachinko's popularity, "Pachinko dependence" has become topical news. The purpose of this study was to investigate beta-endorphin, catecholamines, immune system responses and heart rate during the playing of Pachinko. The following significant results were observed. (1) Plasma concentration of beta-endorphin increased before playing Pachinko and while in the Pachinko-center (p < 0.05). (2) Beta-endorphin and norepinephrine increased when the player began to win (i.e. at "Fever-start") compared to baseline (p < 0.05). (3) Beta-endorphin, norepinephrine and dopamine increased when the winning streak finished (i.e. at "Fever-end") compared to baseline (p < 0.05-0.01). (4) Norepinephrine increased past 30 minutes after "Fever-end" compared to baseline (p < 0.05). (5) Heart rate increased before "Fever-start" compared to baseline, peaked at "Fever-start" and rapidly decreased to match rates measured at rest. But the increase was observed from 200 seconds after "Fever-start" (p < 0.05-0.001). (6) There was a positive correlation between the number of hours subjects played Pachinko in a week and the differences between beta-endorphin levels at "Fever-start" and those at rest (p < 0.05). (7) The number of T-cells decreased while the number of NK cells increased at "Fever-start" compared to baseline (p < .05). These results suggest that intracerebral substances such as beta-endorphin and dopamine are involved in the habit-forming behavior associated with Pachinko. (+info)Effect of raised plasma beta endorphin concentrations on peripheral pain and angina thresholds in patients with stable angina. (4/492)
OBJECTIVE: To determine whether changes in plasma concentrations of beta endorphins alter angina threshold and peripheral pain threshold in patients with stable angina. DESIGN: Latin square design comparison of angina thresholds by exercise treadmill test and peripheral pain thresholds using a radiant heat source in eight patients with stable angina under control conditions, after stimulation of pituitary beta endorphin release by ketoconazole, after suppression of pituitary beta endorphin release by dexamethasone, and after blockade of opioid receptors by intravenous naloxone. RESULTS: An approximately fivefold increase in circulating concentrations of beta endorphins was found after administration of ketoconazole (mean (SEM): 13.9 (1.2) v 73.8 (6.2) pg/ml; p < 0.05), which was associated with an increase in peripheral pain threshold to a radiant heat source (time to onset of pain perception 72 (19) v 123 (40) seconds; p < 0.05), but no significant difference in angina threshold. A reduction in circulating concentrations of beta endorphins after pretreatment with dexamethasone was statistically non-significant (13.9 (1.2) v 9.0 (1.5) pg/ml; NS) and was not associated with any change in either peripheral pain or angina thresholds. No effects were seen after blockade of opioid receptors by previous administration of intravenous naloxone. CONCLUSIONS: Increased plasma concentrations of beta endorphins alter peripheral pain threshold but not angina threshold in patients with stable angina pectoris. (+info)The interaction of bioactive peptides with an immobilized phosphatidylcholine monolayer. (5/492)
The interaction of three bioactive peptides, bombesin, beta-endorphin, and glucagon with a phosphatidylcholine monolayer that was immobilized to porous silica particles and packed into a stainless steel column cartridge, has been studied using dynamic elution techniques. This immobilized lipid monolayer provides a biophysical model system with which to study the binding of peptides to a lipid membrane. In particular, the influence of temperature and methanol concentration on the affinity of each peptide for the immobilized lipid surface was assessed. For all test peptides, nonlinear retention plots were observed at all temperatures that contrasted sharply with the simple linear plots observed for the small unstructured control molecules N-acetyltryptophanamide and diphenylalanine. An analysis of the thermodynamics of the interaction of peptides with the immobilized monolayer was also carried out. The results revealed that while the peptides interacted with the monolayer predominantly through hydrophobic interactions, the relative contribution of DeltaH(assoc)(O) and DeltaS(assoc)(O) to the overall free energy of association was dependent on the temperature and methanol concentration. In particular, it was evident that under most conditions, the binding of the peptides to the immobilized lipid monolayer was enthalpy-driven, i.e., mediated by nonclassical hydrophobic interactions. Significant band-broadening and asymmetric and split peaks were also observed for bombesin, beta-endorphin, and glucagon at different temperatures and methanol concentrations. These changes in affinity and peak shape are consistent with the formation of multiple conformational species during the interaction of these peptides with the lipid monolayer. In addition, the binding behavior of the three test peptides on an n-octylsilica surface that lacked the phospho headgroups of the phospholipid was significantly different from that observed with the immobilized phosphatidylcholine surface, indicating a specificity of interaction between the peptides and the lipid surface. Overall, these experimental results demonstrate that the biomimetic phosphatidylcholine monolayer provides a stable and sensitive system with which to explore the molecular mechanism of peptide conformational changes during membrane interactions. (+info)The stress response of the gilthead sea bream (Sparus aurata L.) to air exposure and confinement. (6/492)
We investigated short-term effects (up to 24 h) of air exposure and confinement, and long-term effects (up to 11 days) of confinement, to elucidate signalling pathways in the stress response of gilthead sea bream Sparus aurata L. Plasma glucose and lactate were taken as indicators of sympathetic activation, and alpha-melanocyte stimulating hormone (alpha-MSH), adrenocorticotrophic hormone (ACTH) and cortisol as indicators of activation of the brain-pituitary-interrenal (BPI) axis. Air exposure for 3 min resulted, within 30 min, in an increase in plasma concentrations of cortisol, alpha-MSH, glucose, lactate, osmolality and plasma Na, Cl and Mg. Plasma ACTH and beta-endorphin and plasma K, Ca and P did not change. We conclude that air exposure mainly activates the brain-sympathetic-chromaffin cell (BSC) axis. In fish confined at a density of 70 kg/m(3) (compared with 4 kg/m(3) in controls), cortisol, ACTH and alpha-MSH increased within 1 h, indicating activation of the BPI axis. Plasma glucose, Na, Cl and Mg increased with an 8 h delay compared with the response to air exposure. No changes in plasma lactate, osmolality, K, Ca and P were observed. Long-term confinement induced a biphasic cortisol response with peaks at 1 h and at 2 and 3 days. A gradual increase in plasma beta-endorphin concentrations peaked at 7 days; the concentration of alpha-MSH increased rapidly within 1 h and then declined to control values 4 days after the onset of confinement. No changes in ACTH were detected. Our data provide evidence that a stressor-specific activation of the BSC and BPI axes may occur in Sparus aurata. (+info)Strenuous resistive breathing induces proinflammatory cytokines and stimulates the HPA axis in humans. (7/492)
Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), powerful stimulants of the hypothalamic-pituitary-adrenal (HPA) axis, increase in response to whole body exercise. Strenuous inspiratory resistive breathing (IRB), a form of clinically relevant "exercise" for the respiratory muscles, produces beta-endorphin through a largely unknown mechanism. We investigated (in 11 healthy humans) whether strenuous IRB produces proinflammatory cytokines and beta-endorphin in parallel with stimulation of the HPA axis, assessed by concurrent measurement of ACTH. Subjects underwent either severe [at 75% of maximal inspiratory pressure (P(m) (max))] or moderate (at 35% of P(m) (max)) IRB. Plasma cytokines, beta-endorphin, and ACTH were measured at rest (point R), at the point at which the resistive load could not be sustained (point F), and at exhaustion [15 min later (point E)]. During severe IRB, IL-1beta increased from 0.83 +/- 0.12 pg/ml at point R to 1.88 +/- 0. 53 and 4.06 +/- 1.27 pg/ml at points F and E, respectively (P < 0. 01). IL-6 increased from 5.30 +/- 1.02 to 10.33 +/- 2.14 and 11.66 +/- 2.29 pg/ml at points F and E, respectively (P = 0.02). ACTH and beta-endorphin fluctuated from 20.87 +/- 5.49 and 25.03 +/- 3.97 pg/ml at point R to 22.97 +/- 4.41 and 26.32 +/- 3.93 pg/ml, respectively, at point F and increased to 46.96 +/- 8.55 and 40.32 +/- 5.94 pg/ml, respectively, at point E (P < 0.01, point E vs. point F). There was a positive correlation between the IL-6 at point F and the ACTH and beta-endorphin at point E (r = 0.88 and 0.94, respectively; P < 0.01) as well as between the increase in IL-6 (between points R and F) and the increases in ACTH and beta-endorphin (between points F and E, r = 0.91 and 0.92, respectively; P < 0.01). Moderate IRB did not produce any change. We conclude that severe IRB produces proinflammatory cytokines and stimulates the HPA axis in humans secondary to the production of cytokines (especially IL-6). (+info)Localization of pro-opiomelanocortin mRNA transcripts and peptide immunoreactivity in rat heart. (8/492)
OBJECTIVE: alpha-Melanocyte-stimulating hormone (alpha-MSH), beta-endorphin and other pro-opiomelanocortin-(POMC) derived peptides have been detected in the heart, but it is uncertain whether they are synthesized by cardiomyocytes or by cardiac nerves innervating the heart. The objective of this study was to determine whether POMC peptides are synthesized by cardiomyocytes. METHODS: Pro-opiomelanocortin peptides were localized in rat heart by immunohistochemistry using antisera against alpha-MSH, beta-endorphin and alpha N-acetyl-beta-endorphin, the predominant POMC peptides found in heart. Pro-opiomelanocortin mRNA was investigated by reverse transcription polymerase chain reaction (RT-PCR) using primers that discriminate between full-length POMC mRNA and a 5' truncated POMC transcript that is presumed to be non-functional. RESULTS: alpha-Melanocyte-stimulating hormone, beta-endorphin and alpha N-acetyl-beta-endorphin immunoreactivities were localized in atrial myocytes, particularly in the atrial appendages, but not to a significant extent in ventricular myocytes. Cardiac nerves were not immunostained. Atrial natriuretic peptide (ANP) immunoreactivity was similarly distributed in the adult heart. In neonatal heart, POMC-peptide and ANP immunoreactivities were present in both atrial and ventricular myocytes. RT-PCR amplification showed that full-length POMC mRNA transcripts were present in both atrial and ventricular tissue and provide evidence that 5' truncated POMC mRNA is expressed in heart. CONCLUSIONS: These results support the hypothesis that cardiomyocytes synthesize POMC peptides. (+info)
Beta-Endorphin
... or β-Endorphin is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons ... It is one of three endorphins that are produced in humans, the others of which include α-endorphin and γ-endorphin. The amino ... CID 16132316 from PubChem - β-endorphin CID 3081525 from PubChem - β-endorphin (1-9) CID 133304 from PubChem - β-endorphin (2-9 ... Loh HH, Tseng LF, Wei E, Li CH (August 1976). "beta-endorphin is a potent analgesic agent". Proceedings of the National Academy ...
Alpha-Endorphin
The three endorphins that play a role in this response are Alpha-endorphins, Beta-endorphins, and Gamma-endorphins which are ... The most studied endorphin of the three is Beta-endorphin. Alpha-endorphins are known to contain one less amino acid than gamma ... Endorphin amphetamines Beta-Endorphin Hazum E, Chang KJ, Cuatrecasas P (September 1979). "Specific nonopiate receptors for beta ... Ranking based on length, alpha endorphins fall as the shortest chain with 16 amino acids. Meanwhile, the beta-endorphin has the ...
Endorphins
"Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia". ... The class of endorphins consists of three endogenous opioid peptides: α-endorphin, β-endorphin, and γ-endorphin. The endorphins ... α-endorphin has the shortest sequence, and β-endorphin has the longest sequence. α-endorphin and γ-endorphin are primarily ... While β-endorphin is studied for its opioid activity, α-endorphin and γ-endorphin both lack affinity for opiate receptors and ...
Derek George Smyth
Smyth, D.G. (2016) Lipotropin & beta-endorphin: a perspective. J. Mol Endocrinol.56, T13-25. (Articles with short description, ... A much more potent analgesic than any of the other endorphins … it is also much longer-lived in the brain. This led Dr Smyth to ... Davis, Joel (1984). Endorphins: New Waves in Brain Chemistry. Garden City, New York: Dial Press. pp. 44-45. ISBN 9780385278560 ... Smyth, D.G., Smith, C.C.F. and Zakarian, S. (1981) Isolation and identification of two new peptides related to β-endorphin. In ...
Sauna
Bender T, Nagy G, Barna I, Tefner I, Kádas E, Géher P (July 2007). "The effect of physical therapy on beta-endorphin levels". ...
Exercise
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Cunha GS, Ribeiro JL, Oliveira AR (June 2008). "[Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras ... β-endorphin (an endogenous opioid), and phenethylamine (a trace amine and amphetamine analog). Preliminary evidence from a 2012 ...
Euphoria
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras Endocrinol Metabol (in Portuguese). 52 (4): 589- ... β-endorphin (an endogenous opioid), and anandamide (an endogenous cannabinoid). Euphoria can occur as a result of dancing to ... thought to be linked to cerebral β-endorphin activity. The substantial increase in phenylacetic acid excretion in this study ...
Neurobiological effects of physical exercise
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Cunha GS, Ribeiro JL, Oliveira AR (June 2008). "[Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras ... β-Endorphin (contracted from "endogenous morphine") is an endogenous opioid neuropeptide that binds to μ-opioid receptors, in ... A review on β-endorphin and exercise noted that an individual's mood improves for the remainder of the day following physical ...
Substance dependence
Role of beta-endorphin and cAMP in addiction and mania. Society for Neuroscience Abstracts. 15:149, 1998. Koob G, Kreek MJ ( ...
Estetrol (medication)
"Effect of estetrol on Beta-Endorphin level in female rats". Steroids. 95: 104-10. doi:10.1016/j.steroids.2015.01.003. PMID ... ISSN 1530-0374 Hagen AA, Barr M, Diczfalusy E (June 1965). "Metabolism of 17-beta-oestradiol-4-14-C in early infancy". Acta ... However, animal studies investigating the effects of estetrol on levels of allopregnanolone and β-endorphin in various brain ... effects in some regions of the brain by mediating weak estrogenic effects on the levels of allopregnanolone and β-endorphin ...
Ahmed Okasha
The brain's opium: Human beta-endorphins. A. Okasha. Egypt. J. Psychiat. 1979.vol. 2, no. 1, pp 135-137 1980 54. A study of ...
Gamma-Endorphin
... γ-Endorphin is equal to the first 17 amino acids of beta-Endorphin. Similar to other endorphins, research focusing upon γ- ... γ-Endorphin (gamma-Endorphin) is an opioid peptide that is characterized by the presence of 17 amino acids. The first 16 amino ... Further research is needed, but if γ-endorphin does indeed possess such characteristics, the substance could eventually be ... endorphin has been ongoing since its discovery in the 1970s. Yet, most of the information about the substance's exact role ...
Leu-enkephalin
Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ...
Arcuate nucleus
The release of a POMC product, beta-endorphin is regulated by NPY. Centrally projecting neurons that make somatostatin; the ... Proopiomelanocortin (POMC) is a precursor polypeptide that is cleaved into MSH, ACTH, and β-endorphin and expressed in the ... β-endorphin, melanocyte-stimulating hormone (MSH), and somatostatin. ...
Species-typical behavior
Keverne, EB; Martensz, ND; Tuite, B (1989). "Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by ... influences the endocrine system-it appears to be relaxing to those who participate due to the release of beta-endorphin. In ...
Social grooming
Beta-endorphins are found in neurons in the hypothalamus and the pituitary gland. Beta-endorphins are found to be opioid ... Beta- endorphins have been difficult to measure in animal species, differently from oxytocin which can be measured by sampling ... A study in monkeys shows the changes in opiate expression in the body, mirroring changes in beta-endorphin levels, influences ... Grooming stimulates the release of beta-endorphin, which is one physiological reason for why grooming appears to be relaxing. ...
Indoor tanning
... "increase serum beta-endorphin levels by 44%". Beta-endorphin is associated with feelings of relaxation and euphoria, including ... it also triggers the synthesis of vitamin D and endorphins in the skin. In 1890 the Danish physician Niels Ryberg Finsen ...
5-HT1A receptor
Koenig JI, Gudelsky GA, Meltzer HY (May 1987). "Stimulation of corticosterone and beta-endorphin secretion in the rat by ... "Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response". Progress in Neuro- ... β-Endorphin secretion may contribute to antidepressant, anxiolytic, and analgesic effects. 5-HT1A receptors can be located on ... Ignarro LJ (June 2008). "Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol". ...
Lipotropin
Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ... In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments of β-lipotropin. β-endorphin is the predominant ... beta-Lipotropin at the US National Library of Medicine Medical Subject Headings (MeSH) gamma-Lipotropin at the US National ... Birdsall and Hulme demonstrated that the C-fragment of lipotropin (β-endorphin) has a high affinity for opiate receptors in the ...
Corticotropin-releasing hormone
"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin". ... β-endorphin). ACTH stimulates the synthesis of cortisol, glucocorticoids, mineralocorticoids and DHEA. In the short term, CRH ...
Benjamin Weiss (scientist)
Sellinger‑Barnette, M. and Weiss, B.: Interaction of beta‑endorphin and other opioid peptides with calmodulin. Mol. Pharmacol. ... Greenberg, L.H. and Weiss, B.: Beta adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to ... Greenberg, L.H. and Weiss, B.: Ability of aged rats to alter beta-adrenergic receptors of brain in response to repeated ... Weiss, B., Greenberg, L.H. and Cantor, E.: Denervation supersensitivity and beta-adrenergic receptors as a function of age. In ...
Perceived Stress Scale
... and beta-endorphin". Psychoneuroendocrinology. 20 (5): 499-508. doi:10.1016/0306-4530(94)00077-N. PMID 7675934. S2CID 30375128 ...
PMSF
... given systemically produces naloxone-reversible analgesia and potentiates effects of beta-endorphin given centrally". Life ...
Functional hypothalamic amenorrhea
By stimulating beta-endorphin, a hypothalamic and pituitary endogenous peptide, CRH can indirectly alter LH function by acting ... As a result, ACTH is released from the pituitary along with other pro-opiomelanocortin-related peptides such as beta-endorphin ... CRH also stimulates secretion of beta(β)-endorphins, which suppresses release of GnRH and dopamine. Inhibition of dopamine ... of the hypothalamic-pituitary system appears to be manifested through increased secretion of CRH and beta-endorphin by the ...
Cholecystokinin A receptor
In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. ...
Effects of nicotine on human brain development
... resulting in increased levels of epinephrine and beta-endorphin. Its physiological effects stem from the stimulation of ... glutamate and endorphins. Nicotine interferes with the blood-brain barrier function, and as a consequence raises the risk of ... endorphins, and several neuropeptides, including proopiomelanocortin-derived α-MSH and adrenocorticotropic hormone. ...
Pituitary gland
Knepel, W; Homolka, L; Vlaskovska, M; Nutto, D (1984). "Stimulation of adrenocorticotropin/beta-endorphin release by synthetic ... and beta-endorphin, and melanocyte-stimulating hormone are released under the influence of hypothalamic corticotropin-releasing ...
Nicotine dependence
... resulting in increased levels of adrenaline and beta-endorphin. Its physiological effects stem from the stimulation of ... endorphins, and several neuropeptides. Repeated exposure to nicotine can cause an increase in the number of nicotinic receptors ...
Electronic cigarette
... resulting in increased levels of epinephrine and beta-endorphin. Its physiological effects stem from the stimulation of ... endorphins, and several neuropeptides, including proopiomelanocortin-derived α-MSH and adrenocorticotropic hormone. ...
Sports nutrition
... norepinephrine and beta-Endorphin. The adenosine receptor antagonism of caffeine accounts for the first two, while the latter ...
Pre-Bötzinger complex
They are found within the pre-BötC and act via alpha-1, alpha-2, and beta-noradrenergic mechanisms. NE induces ICAN-dependent ... These include norepinephrine, serotonin, acetylcholine, substance P, ATP, TRH, somatostatin, dopamine, endorphins, and ...
Huda Akil
After characterizing the anatomy of four opioid peptides, beta-endorphin, dynorphin, methionine enkephalin, and leucine ... Akil and colleagues are best known for providing the first physiological evidence for a role of endorphins in the brain and ... Young, Elizabeth A.; Akil, Huda (1988). "Paradoxical effect of corticosteroids on pituitary ACTH/β-endorphin release in ... enkephalins and endorphins with a concurrent reduction in pain responsiveness. Akil continued research in the area of opioid ...
Han Chinese
... beta-endorphin (the most powerful of the body's natural painkillers), follicle-stimulating hormone and luteinizing hormone (the ...
List of opioids
Big dynorphin Dynorphin A Dynorphin B Leumorphin Structures Endomorphin-1 Endomorphin-2 α-Endorphin β-Endorphin γ-Endorphin α- ... Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine ( ...
Phenethylamine
... or by cross-coupling with beta-amino organozinc reagents, or reacting a brominated arene with beta-aminoethyl organolithium ... thought to be linked to cerebral β-endorphin activity. The substantial increase in phenylacetic acid excretion in this study ... Yang, HY; Neff, NH (1973). "Beta-phenylethylamine: A specific substrate for type B monoamine oxidase of brain". The Journal of ... Suzuki O, Katsumata Y, Oya M (1981). "Oxidation of beta-phenylethylamine by both types of monoamine oxidase: examination of ...
Beta (disambiguation)
... which produces insulin Beta sheet, a secondary protein structure Beta-endorphin, a kind of neurotransmitter SARS-CoV-2 Beta ... Beta (B, β) is the second letter of the Greek alphabet. Beta or BETA may also refer to: Beta (film), a 1992 Bollywood film ... or beta-1 and beta-2, adrenergic receptors Beta, a rank in a community of social animals; See Alpha Beta carbon, in organic ... "BETA" National Beta Club, a high school honor society South Texas Business Education & Technology Academy (BETA) Beta, Ohio, a ...
Cannabinoid
July 2008). "Beta-caryophyllene is a dietary cannabinoid". Proceedings of the National Academy of Sciences of the United States ... has often been attributed to the release of endorphins, but newer research suggests that it might be due to endocannabinoids ... A widespread dietary terpene, beta-caryophyllene, a component from the essential oil of cannabis and other medicinal plants, ...
Leumorphin
... the U-69,593-insensitive site appears to be the beta endorphin-specific epsilon receptor". The Journal of Pharmacology and ...
Nonsense-mediated decay
For instance, the blood disorder Beta thalassemia is inherited and caused by mutations within the upstream of the β-globin gene ... b-endorphin, and a-, b- and c-melanocyte-stimulating hormone (MSH).[citation needed] These peptides then interact with ...
Insulin-degrading enzyme
... and β-endorphin. Considerable interest in IDE has been stimulated due to the discovery that IDE can degrade amyloid beta (Aβ), ... April 2003). "Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor ... Kurochkin IV, Goto S (May 1994). "Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin ... Kerr ML, Small DH (April 2005). "Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, ...
Beta-Neoendorphin
Neoendorphin Minamino N.; Kangawa K.; Chino N. (1981). "β-Neo-endorphin, a new hypothalamic 'big' leu-enkephalin of porcine ...
Tanning dependence
There is evidence that UV exposure produces beta-endorphin in the epidermis and conflicting evidence of this opioid being ...
Neurotransmitter
Beta-Endorphin is a relatively well-known example of a peptide neurotransmitter because it engages in highly specific ... An example of a receptor agonist is morphine, an opiate that mimics effects of the endogenous neurotransmitter β-endorphin to ...
Cardiac fibrosis
September 1986). "Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception: possible ...
List of acupuncture points
... and mechanical wave activation of the calcium ion channel to beta-endorphin secretion. In practice, acupuncture points are ...
Joe Theismann
"Super Beta Prostate® - America's #1 Prostate Supplement". superbeta.com. Retrieved October 6, 2018. "Joe Theismann's Super Beta ... The endorphins had kicked in, and I was not in any great pain." As Theismann was down, Taylor waved for emergency medical ... Super Beta Prostate, and easyMedicare. Theismann fathered three children - Joseph Jr., Amy, and Patrick - with his first wife, ...
Alcohol and sex
... beta-endorphin and prolactin in human adults of both sexes". Alcohol and Alcoholism. 37 (2): 169-73. doi:10.1093/alcalc/37.2. ...
Heart rate
Most involve stimulant-like endorphins and hormones being released in the brain, some of which are those that are 'forced'/' ... Norepinephrine binds to the beta-1 receptor. High blood pressure medications are used to block these receptors and so reduce ... Epinephrine and norepinephrine have similar effects: binding to the beta-1 adrenergic receptors, and opening sodium and calcium ... It also impacts the beta adrenergic response similar to epinephrine and norepinephrine. Calcium ion levels have a great impact ...
Enkephalin
... also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into ... "Endorphins". AccessScience. doi:10.1036/1097-8542.232500. Henry MS, Gendron L, Tremblay ME, Drolet G (2017). "Enkephalins: ... There are three well-characterized families of opioid peptides produced by the body: enkephalins, B-endorphin, and dynorphins. ... The other endogenous opioids are dynorphins (that bind to kappa receptors), endorphins (mu receptors), endomorphins, and ...
Reduction of elevated CSF beta-endorphin by fenfluramine in infantile autism
Beta-endorphin is involved in the anorexic effect of fenfluramine … ... Reduction of elevated CSF beta-endorphin by fenfluramine in infantile autism Pediatr Neurol. 1987 Mar-Apr;3(2):83-6. doi: ... Beta-endorphin is involved in the anorexic effect of fenfluramine and may play a role in autism. Nine children with infantile ... Beta-endorphin was elevated significantly in the baseline autistic group (p less than .005) and was reduced toward control ...
Increased plasma beta-endorphin levels in hereditary angioedema - PubMed
... and beta-lipotropin (BLPH) plasma concentrations (by means of an HPLC-RIA coupled method) during attacks as well as during ... We measured beta-endorphin (BE) and beta-lipotropin (BLPH) plasma concentrations (by means of an HPLC-RIA coupled method) ... Increased plasma beta-endorphin levels in hereditary angioedema R Perricone 1 , C Moretti, C De Carolis, G De Sanctis, L Gnessi ... Increased plasma beta-endorphin levels in hereditary angioedema R Perricone et al. Immunopharmacology. 1989 Sep-Oct. ...
Alpha-theta brainwave training and beta-endorphin levels in alcoholics - PubMed
Alpha-theta brainwave training and beta-endorphin levels in alcoholics E G Peniston et al. Alcohol Clin Exp Res. 1989 Apr. ... Alpha-theta brainwave training and beta-endorphin levels in alcoholics E G Peniston 1 , P J Kulkosky ... Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence ... Application of brainwave treatment, a relaxation therapy, appears to counteract the increase in circulating beta-endorphin ...
BEEF LUNG OR BETA-ENDORPHIN HUMAN OR COFFEA ARABICA SEED, ROASTED OR L - Books - NCBI
... "beta-endorphin"[All Fields] OR ("beta"[All Fields] AND "endorphin"[All Fields]) OR "beta endorphin"[All Fields]) AND ("humans"[ ... BEEF LUNG OR BETA-ENDORPHIN HUMAN OR COFFEA ARABICA SEED, ROASTED... (2472) BEEF LUNG OR BETA-ENDORPHIN HUMAN OR COFFEA ARABICA ... Did you mean: beef lung OR beta-endorphin human OR coffea arabica seed, roasted OR lobelia cardinali whole OR 54-11-5 OR ... Did you mean: beef lung OR beta-endorphin human OR coffea arabica seed, roasted OR lobelia cardinali whole OR 54-11-5 OR ...
DailyMed - VIATREXX-GI- anti-interleukin 1, ankle articulations, beta endorphin, bfgf, calcaneal tendon, hip articulation, knee...
Label: VIATREXX-GI- anti-interleukin 1, ankle articulations, beta endorphin, bfgf, calcaneal tendon, hip articulation, knee ... anti-interleukin 1, ankle articulations, beta endorphin, bfgf, calcaneal tendon, hip articulation, knee articulation, liver, ... VIATREXX-GI- anti-interleukin 1, ankle articulations, beta endorphin, bfgf, calcaneal tendon, hip articulation, knee ... VIATREXX-GI- anti-interleukin 1, ankle articulations, beta endorphin, bfgf, calcaneal tendon, hip articulation, knee ...
MedlinePlus - Search Results for: BEEF LUNG OR "BETA-ENDORPHIN" HUMAN OR COFFEA ARABICA "SEED," ROASTED OR LOBELIA CARDINALIS...
Beta-endorphin response to oral glucose tolerance test in obese and non-obese pre- and postmenopausal women
Beta-endorphin (beta-EP) is a neuropeptide involved in several brain functions, regulating the reproductive axis and behavioral ... Beta-endorphin (beta-EP) is a neuropeptide involved in several brain functions, regulating the reproductive axis and behavioral ... Beta-endorphin response to oral glucose tolerance test in obese and non-obese pre- and postmenopausal women. Stomati, M.;Bersi ... Beta-endorphin response to oral glucose tolerance test in obese and non-obese pre- and postmenopausal women / Stomati, M.*; ...
QuickDetect™ beta-Endorphin (Human) ELISA Kit | E4458 | Biovision
QuickDetect™ beta-Endorphin (Human) ELISA Kit Biovision QuickDetect™ beta-Endorphin (Human) ELISA Kit. (No reviews yet) Write a ... It is one of five endorphins that are produced in human, the others of which include α-endorphin, γ-endorphin, α-neoendorphin, ... β-Endorphin (beta-EP) is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the ... β-Endorphin (beta-EP) is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the ...
Human bEP(Beta-Endorphin) ELISA Kit - AGTC Sequencing
Human bEP(Beta-Endorphin) ELISA Kit. Human bEP(Beta-Endorphin) ELISA Kit. To Order Contact us below: [email protected] ... Description: Quantitative sandwich ELISA for measuring Human Beta-Endorphin (Beta-EP) Kit in samples from cell culture ... Description: Quantitative sandwich ELISA for measuring Human Beta-Endorphin (Beta-EP) Kit in samples from cell culture ... Description: Quantitative sandwich ELISA for measuring Human Beta-Endorphin (Beta-EP) Kit in samples from cell culture ...
Beta Endorphins are not responsible for delayed gastric emptying of digestible solids after exercise in professional cyclists....
Beta Endorphins are not responsible for delayed gastric emptying of digestible solids after exercise in professional cyclists. ... Beta Endorphins are not responsible for delayed gastric emptying of digestible solids afte ... Basal β-endorphin levels were lower in cyclists vs controls (p. exercise intensity (p. gastric emptying of solids with or ... The aim of this preliminary study was to evaluate the role of β-endorphins, inhibitors of gastric motility, in these findings. ...
2000, Beta- endorphin and stress hormones in patients affected by osteoarthritis undergoing thermal mud therapy | Kurwissen
Beta-Endorphin and the Endocrine Pancreas: Studies in Healthy and Diabetic Human Beings<...
In nondiabetic subjects, beta-endorphin also increased plasma insulin concentrations. The threshold dose of beta-endorphin for ... In nondiabetic subjects, beta-endorphin also increased plasma insulin concentrations. The threshold dose of beta-endorphin for ... In nondiabetic subjects, beta-endorphin also increased plasma insulin concentrations. The threshold dose of beta-endorphin for ... In nondiabetic subjects, beta-endorphin also increased plasma insulin concentrations. The threshold dose of beta-endorphin for ...
Effect of low frequency of interferential therapy on plasma beta-endorphin levels in rats<...
This study aimed to investigate the effect of IFT on plasma beta-endorphin (BEND) levels in the rat model as a proposed ... This study aimed to investigate the effect of IFT on plasma beta-endorphin (BEND) levels in the rat model as a proposed ... This study aimed to investigate the effect of IFT on plasma beta-endorphin (BEND) levels in the rat model as a proposed ... This study aimed to investigate the effect of IFT on plasma beta-endorphin (BEND) levels in the rat model as a proposed ...
POMC gene: MedlinePlus Genetics
Another peptide produced from POMC is β-endorphin. Attachment of β-endorphin to proteins in the brain called opioid receptors ... Three similar peptides called alpha-, beta-, and gamma-melanocyte stimulating hormones (α-, β-, and γ-MSH) are also cut from ... As a result, there is an absence of the peptides made from POMC, including ACTH, α-MSH, β-MSH, β-endorphin, and sometimes γ-MSH ... Shortage of γ-MSH or β-endorphin does not seem to cause health problems in people with this condition. ...
Time-dependent sensitization of plasma beta-endorphin in community elderly with self-reported environmental chemical odor...
Hemorrhagic Shock: Practice Essentials, Pathophysiology, Epidemiology
Biomarkers Search
beta-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: lack of significant beta-endorphin. ... 1. Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia.. Crine P ... 6. Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis. Further ... Phosphorylation of beta-lipotropin, beta-endorphin, corticotropin, and parathyroid hormone: a potential control for peptide ...
Freek's corner by freek - Shapeways Shops
Publication Detail
NIAAA Director's Report on Institute Activities to The 121st Meeting of the National Advisory Council on Alcohol Abuse and...
Beta-Endorphin Cell Transplantation Restores Endocrine and Immune Deficits Induced by Fetal Alcohol Exposure. Previous studies ... In this study, investigators further examined the functional deficits that result from the lack of these beta-endorphin cells, ... Researchers injected stem cells that make beta-endorphin into the hypothalamus, and this restored normal stress response and ... and if neural stem cells could be made into beta-endorphin cells to restore function. ...
Max, Mitchell 1999 - Office of NIH History and Stetten Museum
Ive got some beta-endorphin, which Ive just given inside patients ventricles. We have some beta-endorphin in the freezer. ... I think Rick, Im sure, has talked to you about his discovery of A-beta-mediated pain, and I think a lot of our studies have - ... Now just stimulating A-beta fibers in the leg gave rise to burning pain, where before the capsaicin it had only given rise to a ... It changed patients pain report so that a very faint stimulus that was only stimulating A-beta fibers and was bypassing the ...
Administrative Supplements: Program Summaries | Office of Research on Women's Health
What does running do to your brain? | Running | The Guardian
The endorphin rush hypothesis always had a flaw, however, since beta-endorphin does not cross readily the blood-brain barrier. ... beta-endorphin levels do indeed spike in the brain after a two-hour run. Increased levels endorphin activity in the brain also ... when a series of studies showed that the levels of beta-endorphin increase in your bloodstream during the course of a run. Beta ... The popular idea of the "endorphin rush" was born in the 1980s and 90s, ...
Laugh so you don't cry: how laughing kills the pain - Scientific American Blog Network
... they needed to check for beta endorphin. The hypothesis was that if beta endorphins were elevated and made people feel good ... You see, endorphins, particularly beta-endorphin, regulate pain responses via a central mechanism. So you can measure the ... The authors hypothesize that laughter triggers release of endorphins like beta-endorphin, and elevates pain thresholds through ... Well, these scientists think it might have something to do with endorphins. And endorphins have something to do with PAIN. ...
Study finds link between red hair and pain threshold | National Institutes of Health (NIH)
Patents Represented by Attorney James H. Callwood - Justia Patents Search
... beta..sub.h -endorphin while the Ala.sup.2, D-Lys.sup.2, Leu.sup.5, and [D-Ala.sup.2, D-Leu.sup.5 ] analogs were 8 to 17% as ... beta.-endorphins are described. The synthetic peptides were purified by chromatography on carboxymethylcellulose and partition ... beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha ...
Biomarkers Search
Index by author - December 01, 1985, 28 (6) | Molecular Pharmacology
Binding of a synthetic beta-endorphin peptide to calmodulin. D P Giedroc and D Puett ... Binding of a synthetic beta-endorphin peptide to calmodulin. D P Giedroc and D Puett ... Desensitization and resensitization of beta-adrenergic receptors in a smooth muscle cell line. P J Scarpace, L A Baresi, D A ... Desensitization and resensitization of beta-adrenergic receptors in a smooth muscle cell line. P J Scarpace, L A Baresi, D A ...
ACTH5
- ENDORPHINS are endogenous opiate-like peptides that are released in conjunction with ACTH from the pituitary gland into the systemic circulation under certain conditions, such as those accompanying stress. (elsevierpure.com)
- 12. Studies of peptide hormone biosynthesis and structure: ACTH, endorphin, and related molecules. (nih.gov)
- 20. Biosynthetic studies on ACTH, beta-endorphin, and alpha-melanotropin in the rat. (nih.gov)
- interaction between ACTH and Beta Endorphin chains. (uiuc.edu)
- and Hartman, N. ACTH, cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans. (nih.gov)
Peptides3
- Three similar peptides called alpha-, beta-, and gamma-melanocyte stimulating hormones (α-, β-, and γ-MSH) are also cut from the POMC protein. (medlineplus.gov)
- 8. Sequential formation of beta-endorphin-related peptides in porcine pituitary. (nih.gov)
- 15. Characterization of a common precursor to corticotropin and beta-lipotropin: identification of beta-lipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system. (nih.gov)
Cerebrospinal fluid3
- Beta-endorphin-like immunoreactivity was determined in lumbar cerebrospinal fluid of patients during and before or after treatment with fenfluramine and then was compared to normal controls. (nih.gov)
- Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Beta-Endorphin (bEP) in serum, plasma, cerebrospinal fluid and other biological fluids. (agctsequencing.com)
- Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Beta-Endorphin (bEP) in samples from serum, plasma, cerebrospinal fluid and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
Endogenous opioid2
- β-Endorphin (beta-EP) is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system. (transcriptionfactor.org)
- To enhance *-endorphin (BEP), the endogenous opioid polypeptide that boosts immune activity and decreases stress, we generated BEP neurons by in vitro differentiation from fetal neuronal stem cells and transplanted them into the hypothalami of rats subjected to breast carcinogenesis. (nih.gov)
Serotonin3
- It normalizes serotonin and raises beta endorphin. (learn.edu)
- Depression was correlated with dopamine levels and negatively correlated with levels of serotonin and beta endorphin. (hypnosisdownloads.com)
- The activity/levels of MAO-B in blood platelets, CSF and plasma serotonin beta endorphin GABA concentration in blood. (elixa.com)
ELISA Kit1
- BioVision's beta-EP ELISA kit is a sandwich ELISA assay for the quantitative measurement of beta-EP in human serum, plasma and cell culture supernatants in 90 minutes. (transcriptionfactor.org)
Serum3
- Alcoholics receiving standard medical treatment (abstinence, group psychotherapy, antidepressants) showed a significant elevation in serum beta-endorphin levels at the conclusion of the experiment. (nih.gov)
- Easy, convenient and time-saving method to measure the level of beta-Endorphin in human Serum, plasma, urine, cell culture samples, biological fluid. (transcriptionfactor.org)
- Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse Beta-Endorphin (bEP) in samples from serum, plasma or other biological fluids. (agctsequencing.com)
Opioid receptors1
- Attachment of β-endorphin to proteins in the brain called opioid receptors stimulates signaling for pain relief. (medlineplus.gov)
Neurons2
- 9. Biosynthesis of precursor corticotropin/endorphin-, corticotropin-, alpha-melanotropin-, beta-lipotropin-, and beta-endorphin-like material by cultured neonatal rat hypothalamic neurons. (nih.gov)
- Transplantation of *-endorphin neurons into the hypothalamus promotes immune function and restricts the growth and metastasis of mammary carcinoma. (nih.gov)
Peptide4
- Another peptide produced from POMC is β-endorphin. (medlineplus.gov)
- 10. beta-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: lack of significant beta-endorphin. (nih.gov)
- 16. Phosphorylation of beta-lipotropin, beta-endorphin, corticotropin, and parathyroid hormone: a potential control for peptide processing. (nih.gov)
- A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN . (nih.gov)
Pituitary6
- 1 The peripheral targets of endorphins that are released from the pituitary are uncertain. (elsevierpure.com)
- 2. In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands. (nih.gov)
- 4. Selective processing of beta-endorphin in regions of porcine pituitary. (nih.gov)
- 5. Localization of a 16,000-dalton fragment of the common precursor of adrenocorticotropin and beta-lipotropin in the rat and human pituitary gland. (nih.gov)
- 11. Coordinate control of corticotropin, beta-lipotropin, and beta-endorphin release in mouse pituitary cell cultures. (nih.gov)
- 14. Immunological evidence for two common precursors to corticotropins, endorphins, and melanotropin in the neurointermediate lobe of the toad pituitary. (nih.gov)
Neuropeptide1
- Beta-endorphin (beta-EP) is a neuropeptide involved in several brain functions, regulating the reproductive axis and behavioral changes. (unifi.it)
Humans2
- This means that it's hard to measure endogenous levels of endorphins in humans, as most humans object strenuously to a spinal tap in the name of science. (scientificamerican.com)
- So you can measure the activity of beta-endorphins in humans indirectly, just by measuring their pain tolerance. (scientificamerican.com)
Substances1
- Following Hypnotherapy, there were clinically and statistically significant decreases in depression, anxiety and pain, and increases in beta endorphin-like substances. (hypnosisdownloads.com)
Glucose6
- Previous clinical studies have demonstrated high plasma beta-EP levels in obese subjects and increased beta-EP release after an oral glucose tolerance test (OGTT) in normal or obese women. (unifi.it)
- The aim of the present study was to evaluate plasma beta-endorphin levels in response to an OGTT in pre- and postmenopausal obese and non-obese women, in order to investigate if the decrease in gonadal steroid levels at menopause could modify in a different manner the control of beta-endorphin release in response to glucose administration. (unifi.it)
- A significant increase in plasma beta-EP levels, at 30 and 60 minutes after oral glucose ingestion, was shown in control premenopausal women. (unifi.it)
- In both groups, beta-endorphin increased plasma glucagon concentrations, and this rise was accompanied by a significant increase in plasma glucose concentrations. (elsevierpure.com)
- The threshold dose of beta-endorphin for producing increased plasma concentrations of glucose and glucagon was 0.005 mg - a dose that acutely increased plasma concentrations of beta-endorphin by approximately 40-fold. (elsevierpure.com)
- Glucose, glucagon, and insulin responses to beta-endorphin could not be blocked by intravenous naloxone. (elsevierpure.com)
Evaluate2
- The aim of this preliminary study was to evaluate the role of β- endorphins , inhibitors of gastric motility, in these findings. (bvsalud.org)
- To evaluate this possibility, we infused synthetic human beta-endorphin intravenously in healthy volunteers and in insulin-dependent diabetic patients. (elsevierpure.com)
Levels9
- Application of brainwave treatment, a relaxation therapy, appears to counteract the increase in circulating beta-endorphin levels seen in the control group of alcoholics. (nih.gov)
- Estrogens play a modulatory role on circulating levels of beta-EP in women. (unifi.it)
- In postmenopausal women, regardless of body weight, low basal plasma beta-EP levels were found. (unifi.it)
- No significant modifications to OGTT were shown in plasma beta-EP levels in the other three groups of women. (unifi.it)
- In conclusion, while in premenopausal women the response of plasma beta-EP levels to OGTT is maintained, in postmenopause there is a lack of response to OGTT. (unifi.it)
- Gastric emptying of solids marked with Tc99 while resting and plasmatic levels of β- endorphins were evaluated in 27 healthy controls and 19 professional cyclists (day 1). (bvsalud.org)
- This study aimed to investigate the effect of IFT on plasma beta-endorphin (BEND) levels in the rat model as a proposed analgesic mechanism of IFT. (edu.au)
- The hypothesis was that if beta endorphins were elevated and made people feel good after laughing, these people would ALSO have an increased pain tolerance, as elevated levels of beta endorphin also increase pain tolerance. (scientificamerican.com)
- For the past 20 years, I have used the same method to assist in rejuvenating the body's ability to naturally increase its own DHEA levels: Using the acupuncture technique called Stimulation of the Ring of Fire, using magnesium lotion daily, and a vitamin regimen that includes Vitamin C, MSM, Molybeneum and Beta 1,3 Glucan. (learn.edu)
Plasma2
- We measured beta-endorphin (BE) and beta-lipotropin (BLPH) plasma concentrations (by means of an HPLC-RIA coupled method) during attacks as well as during symptom-free periods in a group of 28 patients with immunochemical (21) or functional (7) Cl inhibitor deficiency. (nih.gov)
- In nondiabetic subjects, beta-endorphin also increased plasma insulin concentrations. (elsevierpure.com)
Chemicals2
- Endorphins are opioid chemicals that you actually produce, in your own body, and which can help combat pain or facilitate feelings associated with reward . (scientificamerican.com)
- Later the brain begins to release chemicals called beta-endorphins which calm and relax. (dreamhawk.com)
Significantly1
- Beta-endorphin was elevated significantly in the baseline autistic group (p less than .005) and was reduced toward control values during fenfluramine treatment. (nih.gov)
Release3
- This suggests that beta-EP release is dependent upon gonadal steroids, while it is only in part influenced by body weight. (unifi.it)
- This eventually leads to glucocorticoid and beta-endorphin release. (medscape.com)
- Technically, what Maum helpers are doing is creating conditions that wipe the brain slate clean so that the mind accepts new input, in the form of suggestion.The alpha brain-wave state induces the internal release of natural opiates and beta endorphins. (dailyfreepress.com)
Human1
- It is one of five endorphins that are produced in human, the others of which include α-endorphin, γ-endorphin, α-neoendorphin, and β-neoendorphin. (transcriptionfactor.org)
Mechanism1
- The results are consistent with a role for beta-endorphin in infantile autism and in the mechanism of fenfluramine treatment. (nih.gov)
Role3
- Beta-endorphin is involved in the anorexic effect of fenfluramine and may play a role in autism. (nih.gov)
- The inhibitory effect of the exercise in the gastric emptying of solids does not seem to be secondary to the action of β- endorphins , that leaves the gastric inhibitory vagal motor circuit a more likely predominant role . (bvsalud.org)
- Beta-endorphin is present in the endocrine pancreas, suggesting that endorphins may have a role in islet-cell function. (elsevierpure.com)
Pain2
- And endorphins have something to do with PAIN. (scientificamerican.com)
- POMC is cut into different hormones, including one that enhances pain perception (melanocyte stimulating hormone) and another that blocks pain (beta-endorphin). (nih.gov)
Studies2
- In behavioral research, studies have shown that β-endorphin is released via volume transmission into the ventricular system in response to a variety of stimuli, and novel stimuli in particular. (transcriptionfactor.org)
- These studies suggest that endorphins may be involved in glucoregulation, that their hyperglycemic action is mediated at least in part by glucagon, and that the effect of beta-endorphin on islet-cell function is relatively resistant to naloxone. (elsevierpure.com)
Brain2
- There is different brain wave states (alpha, beta, theta, delta) and all serves a different function, But the alpha state makes people especially susceptible and open to Conwertion. (dailyfreepress.com)
- Beta brain waves are associated with normal waking consciousness and a heightened state of alertness, logic and critical reasoning. (dailyfreepress.com)
Stress1
- In the broadest sense, β-endorphin is primarily utilized in the body to reduce stress and maintain homeostasis. (transcriptionfactor.org)
Affect1
- Moreover, there is recent evidence to suggest that beta-endorphin is produced in the pancreatic islets, 4 so that endorphin may affect the endocrine pancreas by local as well as by humoral pathways. (elsevierpure.com)
Study1
- A preliminary study / Las Beta endorfinas no son responsables del retardo del vaciamiento gástrico de sólidos en ciclistas profesionales tras el ejercicio. (bvsalud.org)
People1
- Shortage of γ-MSH or β-endorphin does not seem to cause health problems in people with this condition. (medlineplus.gov)
Samples2
- The density of color is proportional to the amount of beta-EP captured from the samples. (transcriptionfactor.org)
- Venous blood samples were collected mined by commercially available radio- using plain tubes for routine tests and chilled immunoassay kits for met-enkephalin, polyethylene tubes containing aprotinin -endorphin and leu-enkephalin (Penin- and/or ethylenediaminetetra-acetic acid sula Laboratories Inc, Division of Bachem, (EDTA). (who.int)