A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.
One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.
A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS OF HYPOTHALAMUS.
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Structurally, they include polypeptide, protein, and glycoprotein molecules.
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Enzymes that catalyze the transfer of an acetyl group, usually from ACETYL COENZYME A, to the N-terminus of a peptide chain.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies produced by a single clone of cells.
Chronic inflammation and granuloma formation around irritating foreign bodies.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
Sensation of enjoyment or gratification.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
An anti-inflammatory 9-fluoro-glucocorticoid.
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
A form of acupuncture with electrical impulses passing through the needles to stimulate NERVE TISSUE. It can be used for ANALGESIA; ANESTHESIA; REHABILITATION; and treatment for diseases.
Decrease in existing BODY WEIGHT.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Designated locations along nerves or organ meridians for inserting acupuncture needles.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
Infection occurring at the site of a surgical incision.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
The study of the effects of drugs on mental and behavioral activity.
Synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.

Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study. (1/492)

OBJECTIVES: The purpose of this study was to test whether cutaneous thermal pain thresholds are related to anginal pain perception. BACKGROUND: Few ischemic episodes are associated with angina; symptoms have been related to pain perception thresholds. METHODS: A total of 196 patients with documented coronary artery disease underwent bicycle exercise testing and thermal pain testing. The Marstock test of cutaneous sensory perception was administered at baseline after 30 min of rest on two days and after exercise and mental stress. Resting hot pain thresholds (HPTs) were averaged for the two baseline visits and divided into two groups: 1) average HPT <41 degrees C, and 2) average HPT > or =41 degrees C, to be clearly indicative of abnormal hypersensitivity to noxious heat. RESULTS: Patients with HPT <41 degrees C had significantly shorter time to angina onset on exercise testing than patients with HPT > or =41 degrees C (p < 0.04, log-rank test). Heart rates, systolic blood pressure and rate-pressure product at peak exercise were not different for the two groups. Resting plasma beta-endorphin levels were significantly higher in the HPT <41 degrees C group (5.9+/-3.7 pmol/liter vs. 4.7+/-2.8 pmol/liter, p = 0.02). Using a Cox proportional hazards model, patients with HPT <41 degrees C had an increased risk of angina (p = 0.03, rate ratio = 2.0). These differences persisted after adjustment for age, gender, depression, anxiety and history of diabetes or hypertension (p < 0.01). CONCLUSIONS: Occurrence of angina and timing of angina onset on an exercise test are related to overall hot pain sensory perception. The mechanism of this relationship requires further study.  (+info)

Enhancing effects of beta-endorphin on glutamate neurotoxicity. (2/492)

AIM: To study the effect of beta-endorphin (beta-End) on monosodium glutamate (MSG)-induced neurotoxicity (GNT). METHODS: Image analysis of neuronal areas and determination of mitochondrial membrane protein-bound Ca2+ and intracellular free Ca2+ ([Ca2+]i) were used. RESULTS: beta-End aggravated MSG-induced neuronal injury in arcuate nucleus of hypothalamus in a dose-dependent manner in the range from 0.5 to 5.0 mg.kg-1. MSG-induced increase in mitochondrial membrane protein-bound Ca2+ was enhanced when treated with beta-End 2 g.L-1. MSG-induced elevation in [Ca2+]i in single neuron was also augmented from 320 +/- 84 to 589 +/- 78 nmol.L-1 by the treatment with beta-End 2 g.L-1. CONCLUSION: beta-End enhanced GNT via aggravating the disruption of intracellular Ca2+ homeostasis induced by MSG.  (+info)

Physiological changes in Pachinko players; beta-endorphin, catecholamines, immune system substances and heart rate. (3/492)

Pachinko is a popular form of recreation in Japan. However, in recent years, along with Pachinko's popularity, "Pachinko dependence" has become topical news. The purpose of this study was to investigate beta-endorphin, catecholamines, immune system responses and heart rate during the playing of Pachinko. The following significant results were observed. (1) Plasma concentration of beta-endorphin increased before playing Pachinko and while in the Pachinko-center (p < 0.05). (2) Beta-endorphin and norepinephrine increased when the player began to win (i.e. at "Fever-start") compared to baseline (p < 0.05). (3) Beta-endorphin, norepinephrine and dopamine increased when the winning streak finished (i.e. at "Fever-end") compared to baseline (p < 0.05-0.01). (4) Norepinephrine increased past 30 minutes after "Fever-end" compared to baseline (p < 0.05). (5) Heart rate increased before "Fever-start" compared to baseline, peaked at "Fever-start" and rapidly decreased to match rates measured at rest. But the increase was observed from 200 seconds after "Fever-start" (p < 0.05-0.001). (6) There was a positive correlation between the number of hours subjects played Pachinko in a week and the differences between beta-endorphin levels at "Fever-start" and those at rest (p < 0.05). (7) The number of T-cells decreased while the number of NK cells increased at "Fever-start" compared to baseline (p < .05). These results suggest that intracerebral substances such as beta-endorphin and dopamine are involved in the habit-forming behavior associated with Pachinko.  (+info)

Effect of raised plasma beta endorphin concentrations on peripheral pain and angina thresholds in patients with stable angina. (4/492)

OBJECTIVE: To determine whether changes in plasma concentrations of beta endorphins alter angina threshold and peripheral pain threshold in patients with stable angina. DESIGN: Latin square design comparison of angina thresholds by exercise treadmill test and peripheral pain thresholds using a radiant heat source in eight patients with stable angina under control conditions, after stimulation of pituitary beta endorphin release by ketoconazole, after suppression of pituitary beta endorphin release by dexamethasone, and after blockade of opioid receptors by intravenous naloxone. RESULTS: An approximately fivefold increase in circulating concentrations of beta endorphins was found after administration of ketoconazole (mean (SEM): 13.9 (1.2) v 73.8 (6.2) pg/ml; p < 0.05), which was associated with an increase in peripheral pain threshold to a radiant heat source (time to onset of pain perception 72 (19) v 123 (40) seconds; p < 0.05), but no significant difference in angina threshold. A reduction in circulating concentrations of beta endorphins after pretreatment with dexamethasone was statistically non-significant (13.9 (1.2) v 9.0 (1.5) pg/ml; NS) and was not associated with any change in either peripheral pain or angina thresholds. No effects were seen after blockade of opioid receptors by previous administration of intravenous naloxone. CONCLUSIONS: Increased plasma concentrations of beta endorphins alter peripheral pain threshold but not angina threshold in patients with stable angina pectoris.  (+info)

The interaction of bioactive peptides with an immobilized phosphatidylcholine monolayer. (5/492)

The interaction of three bioactive peptides, bombesin, beta-endorphin, and glucagon with a phosphatidylcholine monolayer that was immobilized to porous silica particles and packed into a stainless steel column cartridge, has been studied using dynamic elution techniques. This immobilized lipid monolayer provides a biophysical model system with which to study the binding of peptides to a lipid membrane. In particular, the influence of temperature and methanol concentration on the affinity of each peptide for the immobilized lipid surface was assessed. For all test peptides, nonlinear retention plots were observed at all temperatures that contrasted sharply with the simple linear plots observed for the small unstructured control molecules N-acetyltryptophanamide and diphenylalanine. An analysis of the thermodynamics of the interaction of peptides with the immobilized monolayer was also carried out. The results revealed that while the peptides interacted with the monolayer predominantly through hydrophobic interactions, the relative contribution of DeltaH(assoc)(O) and DeltaS(assoc)(O) to the overall free energy of association was dependent on the temperature and methanol concentration. In particular, it was evident that under most conditions, the binding of the peptides to the immobilized lipid monolayer was enthalpy-driven, i.e., mediated by nonclassical hydrophobic interactions. Significant band-broadening and asymmetric and split peaks were also observed for bombesin, beta-endorphin, and glucagon at different temperatures and methanol concentrations. These changes in affinity and peak shape are consistent with the formation of multiple conformational species during the interaction of these peptides with the lipid monolayer. In addition, the binding behavior of the three test peptides on an n-octylsilica surface that lacked the phospho headgroups of the phospholipid was significantly different from that observed with the immobilized phosphatidylcholine surface, indicating a specificity of interaction between the peptides and the lipid surface. Overall, these experimental results demonstrate that the biomimetic phosphatidylcholine monolayer provides a stable and sensitive system with which to explore the molecular mechanism of peptide conformational changes during membrane interactions.  (+info)

The stress response of the gilthead sea bream (Sparus aurata L.) to air exposure and confinement. (6/492)

We investigated short-term effects (up to 24 h) of air exposure and confinement, and long-term effects (up to 11 days) of confinement, to elucidate signalling pathways in the stress response of gilthead sea bream Sparus aurata L. Plasma glucose and lactate were taken as indicators of sympathetic activation, and alpha-melanocyte stimulating hormone (alpha-MSH), adrenocorticotrophic hormone (ACTH) and cortisol as indicators of activation of the brain-pituitary-interrenal (BPI) axis. Air exposure for 3 min resulted, within 30 min, in an increase in plasma concentrations of cortisol, alpha-MSH, glucose, lactate, osmolality and plasma Na, Cl and Mg. Plasma ACTH and beta-endorphin and plasma K, Ca and P did not change. We conclude that air exposure mainly activates the brain-sympathetic-chromaffin cell (BSC) axis. In fish confined at a density of 70 kg/m(3) (compared with 4 kg/m(3) in controls), cortisol, ACTH and alpha-MSH increased within 1 h, indicating activation of the BPI axis. Plasma glucose, Na, Cl and Mg increased with an 8 h delay compared with the response to air exposure. No changes in plasma lactate, osmolality, K, Ca and P were observed. Long-term confinement induced a biphasic cortisol response with peaks at 1 h and at 2 and 3 days. A gradual increase in plasma beta-endorphin concentrations peaked at 7 days; the concentration of alpha-MSH increased rapidly within 1 h and then declined to control values 4 days after the onset of confinement. No changes in ACTH were detected. Our data provide evidence that a stressor-specific activation of the BSC and BPI axes may occur in Sparus aurata.  (+info)

Strenuous resistive breathing induces proinflammatory cytokines and stimulates the HPA axis in humans. (7/492)

Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), powerful stimulants of the hypothalamic-pituitary-adrenal (HPA) axis, increase in response to whole body exercise. Strenuous inspiratory resistive breathing (IRB), a form of clinically relevant "exercise" for the respiratory muscles, produces beta-endorphin through a largely unknown mechanism. We investigated (in 11 healthy humans) whether strenuous IRB produces proinflammatory cytokines and beta-endorphin in parallel with stimulation of the HPA axis, assessed by concurrent measurement of ACTH. Subjects underwent either severe [at 75% of maximal inspiratory pressure (P(m) (max))] or moderate (at 35% of P(m) (max)) IRB. Plasma cytokines, beta-endorphin, and ACTH were measured at rest (point R), at the point at which the resistive load could not be sustained (point F), and at exhaustion [15 min later (point E)]. During severe IRB, IL-1beta increased from 0.83 +/- 0.12 pg/ml at point R to 1.88 +/- 0. 53 and 4.06 +/- 1.27 pg/ml at points F and E, respectively (P < 0. 01). IL-6 increased from 5.30 +/- 1.02 to 10.33 +/- 2.14 and 11.66 +/- 2.29 pg/ml at points F and E, respectively (P = 0.02). ACTH and beta-endorphin fluctuated from 20.87 +/- 5.49 and 25.03 +/- 3.97 pg/ml at point R to 22.97 +/- 4.41 and 26.32 +/- 3.93 pg/ml, respectively, at point F and increased to 46.96 +/- 8.55 and 40.32 +/- 5.94 pg/ml, respectively, at point E (P < 0.01, point E vs. point F). There was a positive correlation between the IL-6 at point F and the ACTH and beta-endorphin at point E (r = 0.88 and 0.94, respectively; P < 0.01) as well as between the increase in IL-6 (between points R and F) and the increases in ACTH and beta-endorphin (between points F and E, r = 0.91 and 0.92, respectively; P < 0.01). Moderate IRB did not produce any change. We conclude that severe IRB produces proinflammatory cytokines and stimulates the HPA axis in humans secondary to the production of cytokines (especially IL-6).  (+info)

Localization of pro-opiomelanocortin mRNA transcripts and peptide immunoreactivity in rat heart. (8/492)

OBJECTIVE: alpha-Melanocyte-stimulating hormone (alpha-MSH), beta-endorphin and other pro-opiomelanocortin-(POMC) derived peptides have been detected in the heart, but it is uncertain whether they are synthesized by cardiomyocytes or by cardiac nerves innervating the heart. The objective of this study was to determine whether POMC peptides are synthesized by cardiomyocytes. METHODS: Pro-opiomelanocortin peptides were localized in rat heart by immunohistochemistry using antisera against alpha-MSH, beta-endorphin and alpha N-acetyl-beta-endorphin, the predominant POMC peptides found in heart. Pro-opiomelanocortin mRNA was investigated by reverse transcription polymerase chain reaction (RT-PCR) using primers that discriminate between full-length POMC mRNA and a 5' truncated POMC transcript that is presumed to be non-functional. RESULTS: alpha-Melanocyte-stimulating hormone, beta-endorphin and alpha N-acetyl-beta-endorphin immunoreactivities were localized in atrial myocytes, particularly in the atrial appendages, but not to a significant extent in ventricular myocytes. Cardiac nerves were not immunostained. Atrial natriuretic peptide (ANP) immunoreactivity was similarly distributed in the adult heart. In neonatal heart, POMC-peptide and ANP immunoreactivities were present in both atrial and ventricular myocytes. RT-PCR amplification showed that full-length POMC mRNA transcripts were present in both atrial and ventricular tissue and provide evidence that 5' truncated POMC mRNA is expressed in heart. CONCLUSIONS: These results support the hypothesis that cardiomyocytes synthesize POMC peptides.  (+info)

Plasma and cerebrospinal fluid beta-endorphin concentrations were radioimmunologically assayed in dogs subjected to spinal cord ischemia induced by infrarenal aortic ligature and in control sham-operated dogs. Plasma beta-endorphin levels rose significantly following surgery in control dogs but were unaffected by spinal ischemia. On the other hand, a significant increase in cerebrospinal fluid beta-endorphin concentration occurred after spinal ischemia, while surgical stress had no significant effect. Thus, the origins of plasma and cerebrospinal fluid beta-endorphin may be different, with the former secreted from the hypophysis and the latter from nervous tissue. Observed changes in cerebrospinal fluid beta-endorphin concentration could be related to the ischemic lesion of nervous tissue while the changes in plasma levels may reflect general stressing factors such as the surgery in our experiments. ...
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Pituitary melanotropes release alpha-melanocyte-stimulating hormone (alpha-MSH) and acetylated beta-endorphin (NAc beta-end) during stress responses. However, effects of stressors on plasma concentrations of these hormones are highly inconsistent among fish species. Here, we show that also within a species, the common carp (Cyprinus carpio), fish sometimes respond with elevated alpha-MSH and NAc beta-end plasma levels, and at other times not. The origin of this variable response was investigated by (1) studying the effects of corticotropin-releasing hormone (CRH) on alpha-MSH and NAc beta-end release in vitro, (2) establishing where in the second messenger pathway coupled to CRH receptors melanotrope responsiveness is determined, and (3) testing modulatory actions of other hypothalamic factors (here opioid beta-endorphin). Melanotropes were in a high or low responsive state to CRH in vitro, which was especially evident when tissue was tested from fish kept at higher ambient water temperatures, ...
Basal serum cortisol, growth hormone, prolactin and immunoreactive (IR) plasma beta-endorphin levels were measured in 31 depressed patients (14 endogenous, 17 nonendogenous) undergoing the dexamethasone suppression test. The endogenously depressed patients had significantly higher (22.55 +/- 1.34 mi …
The opiate antagonist, naloxone, was shown to attenuate the analgesic effect of N2O in mice [1] and subsequently in humans, [2] which led the authors to speculate that opiate receptors mediated the analgesic effect of N2O. However, the dose used (5.0 mg [dot] kg sup -1 in mice) was much larger than the dose required to block responses to exogenously administered opiate narcotics. This may be important because naloxone itself can exert a hyperalgesic effect at high doses. [17] Using smaller doses of naloxone, other investigators have demonstrated a mild enhancing, [18] a mild attenuating, [19] or no effect [20] on N2O analgesia in humans. Later studies showed that plasma beta endorphin concentrations and [Met5]enkephalin [21] concentrations in the cerebrospinal fluid increase after N2O exposure; however, neither the [Met5]enkephalin [4] nor the endorphin [5,6] findings could be corroborated. Subsequent studies revealed that N2O increased beta-endorphin concentrations along the arcuate ...
Under specific environmental conditions, endogenous opioids may selectively influence affective and behavioral processes in that opioid release can attenuate the effects of aversive stimuli. The activation of endogenous opioids associated with increases in blood pressure may serve to attenuate the effect of chronic aversive events and thus contribute to the learning and/or maintenance of essential hypertension, much as predicted within a negative reinforcement paradigm. Seven (unmedicated) hypertensives and seven normotensive controls were evaluated at rest, during a cognitive stressor (mental arithmetic task), and at three subsequent points during the post-stress phase. Dependent measures included systolic and diastolic blood pressures, heart rate, plasma Beta-endorphin levels (derived via radioimmunoassays of venous blood samples), and patient self-reports of subjective discomfort. Baseline, stress, and post-stress blood pressures were significantly higher among hypertensives than ...
Very few clinical trials have been produced to provide evidence that manipulative treatment by chiropractors is beneficial to patients with neck pain. The senior author of this study, Howard T. Vernon, conducted clinical analog studies in which the results of a single manipulation were compared to control procedures. In the first study, a single thoracic manipulation produced a significantly higher rise in cutaneous pain tolerance levels than the shashared/stockpages/cp/conditions/neckpain/m/manipulation group. In the second study, a single manipulation of the cervical spine produced a modest increase in plasma beta-endorphin levels while control and sham procedures dropped. These studies support the idea that pain relief occurs subsequent to manipulation, and to the theory that this pain relief is a result of reflex mechanisms activated by the thrust. The reflex mechanisms can be described as afferent bombardment from the articular and myofascial receptors which produces pre synaptic inhibition ...
This paper outlines the many components of the mammalian immune system and the anatomical and physiological connections suggesting that the nerve system plays a role in the modulation of immune response. The few studies attempting to measure the effect of chiropractic or manipulative treatment on the immune system are reviewed. Their results suggest that chiropractic or manipulative treatment may influence T and B lymphocyte numbers, NK cell numbers, antibody levels, phagocytic activity and plasma beta-endorphin levels. The influence of these effects on the outcome of host resistance is unknown. There is now a need for large, well-planned clinical trials using some of the more sophisticated measures of immune function to establish whether chiropractic treatment can influence the immune response in a clinically significant manner. ...
This paper outlines the many components of the mammalian immune system and the anatomical and physiological connections suggesting that the nerve system plays a role in the modulation of immune response. The few studies attempting to measure the effect of chiropractic or manipulative treatment on the immune system are reviewed. Their results suggest that chiropractic or manipulative treatment may influence T and B lymphocyte numbers, NK cell numbers, antibody levels, phagocytic activity and plasma beta-endorphin levels. The influence of these effects on the outcome of host resistance is unknown. There is now a need for large, well-planned clinical trials using some of the more sophisticated measures of immune function to establish whether chiropractic treatment can influence the immune response in a clinically significant manner. ...
Current evidence suggests that endogenous opioids are released in response to various stressors and that these opioids interact with cells of the immune system, and modulate immune function. However, data substantiating this are conflicting. Therefore, this study endeavored to clarify the role of beta-endorphin (BE) in exercise and immune function. Beta-endorphin exhibited a diurnal rhythm in the horse with peak plasma levels occurring at 0900 hours. Analgesia, tachycardia and mydriasis were also observed at this time, mimicking the effects of morphine in the horse. Therefore, subsequent experiments were performed at 0900 hours during times of increased basal opioid activity. Beta-endorphin levels were increased in response to maximal exercise in the horse. The BE response to exercise was attenuated by physical conditioning and was correlated with exercise intensity. Analgesia was noted in unfit horses but not in fit horses after a standardized exercise bout, suggesting that unfit horses experience
Changes in Serum Leptin and Beta Endorphin Levels with Weight Loss by Electroacupuncture and Diet Restriction in Obesity Treatment. This study aims to investigate the role of changes in leptin and beta endorphin (BE) levels in weight loss following electroacupuncture (EA) application in obesity treatment. EA was applied to 20.... ...
Definition of beta-endorphin in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is beta-endorphin? Meaning of beta-endorphin as a finance term. What does beta-endorphin mean in finance?
2) The endogenous opioids seem likely to be assigned a significant role in the integrated hormonal and metabolic response to exercise. This article reviews the present evidence on exercise and the endogenous opioids, and examines their involvement in a number of widely disparate physiological processes. In considering the role of individual opioid peptides, it is important to remember that many of the tools and techniques now used are still relatively crude. Most studies have demonstrated that serum concentrations of endogenous opioids, in particular beta-endorphin and beta-lipotrophin, increase in response to both acute exercise and training programmes. Elevated serum beta-endorphin concentrations induced by exercise have been linked to several psychological and physiological changes, including mood state changes and exercise-induced euphoria, altered pain perception, menstrual disturbances in female athletes, and the stress responses of numerous hormones (growth hormone, ACTH, prolactin, ...
Naloxone has been reported to have potential benefit in the treatment of stroke. We evaluated the effect of naloxone in a double-blind trial conducted with 15 stroke patients whose deficits ranged from 8 to 60 hours in duration. All but one patient sustained a cerebral infarction. Neurologic function was assessed before and five minutes after each of two injections given to each patient in a double-blind fashion. The injections consisted of naloxone (0.4 mg in 3 patients and 4.0 mg in 12 patients) and saline. Prior to the trial, samples of plasma were obtained for determination of immunoreactive beta-endorphin for each patient. Four patients showed minimal improvement following injection of naloxone, while five patients exhibited a slightly greater improvement following saline injection. There were no significant elevations of plasma beta-endorphin among stroke patients. We conclude that naloxone may not have a significant therapeutic role for stroke in the clinical setting. ...
Naloxone effects on beta-endorphin, cortisol, prolactin, growth hormone, HVA and MHPG in plasma of normal volunteers. Psychopharmacology (Berl). 1981; 74(2):125-8 ...
Baranowska B, Wolińska-Witort E, Martyńska L, Chmielowska M, Mazurczak-Pluta T, Boguradzka A, Baranowska-Bik A. Sibutramine therapy in obese women--effects on plasma neuropeptide Y (NPY), insulin, leptin and beta-endorphin concentrations. Neuro Endocrinol Lett. 2005 Dec; 26(6): 675-679 ...
Baranowska B, Wolińska-Witort E, Martyńska L, Chmielowska M, Mazurczak-Pluta T, Boguradzka A, Baranowska-Bik A. Sibutramine therapy in obese women--effects on plasma neuropeptide Y (NPY), insulin, leptin and beta-endorphin concentrations. Neuro Endocrinol Lett. 2005 Dec; 26(6): 675-679 ...
An 18-20 gauge catheter will be inserted into an arm vein to be used for drawing blood and for administration of either normal saline or naloxone. In a seated position, the patient will breathe quietly through the mouth piece without any resistance. After 5 minutes, 10 ml of venous blood will be removed for measurement of baseline plasma beta-endorphin immunoreactivity. Then, the physician will give the normal saline or naloxone solution intravenously through tubing connected to the catheter. Five minutes after the infusion has been given, the resistance load (obtained at Visit 1) will be added to the inspiratory side of a two-way valve. The patient will be instructed to continue breathing through the resistance for as long as possible. At one minute intervals, the patient will be asked to place a mark on a vertical visual analog scale (VAS) in order to rate separately the intensity and the unpleasantness of dyspnea. When the patient is no longer able to breathe through the resistance system, ...
The opioid neuropeptides have previously been shown to bind to and affect leukocyte function including lymphocyte proliferation, NK-cell activity, mononuclear cell chemotaxis, immunoglobulin synthesis, and lymphokine production. The effect of the opioid peptides beta-endorphin and Met-enkephalin on …
Endogenous opioid beta-endorphin is released by two different systems - neural network and blood. The first system includes the hypothalamus and the neural network leading to the midbrain and brainstem and this way it can affect the pain sensitivity as well as autonomous functions. There is evidence that the hypothalamus nuclei play a vital role in the mediating effect of acupuncture. Damage in the arcuate nucleus eliminates the analgesic effect of low-frequency but not of high-frequency electro acupuncture. Low-frequency electrical stimulation induced circulatory changes in multiple tissues. These effects are eliminated after hypothalamic damage. Increase in the beta-endorphin levels was observed in the animal brain tissue both after the acupuncture treatment and muscular exercise. Although the details are still unknown, experimental and clinical evidence indicates that acupuncture can also affect the sympathetic nervous system on the hypothalamus-hypophysis level (Figure 2).. The second system ...
Beta-endorphin. Polarised light micrograph of crystals of beta-endorphin, an opioid peptide that relieves pain. Endorphins are a group of peptides (small proteins) that occur in the brain. Beta- endorphin is the most active type. Their effects resemble morphine and other opiate drugs, that is, alteration of the perception of pain. Because they are produced by body cells they were named endorphins (endogenous morphines). Besides the nervous system, they occur at other body sites. Their effects on nerve endings are analgesic (pain killing), while they may also control the bodys response to stress as well as determining mood and pleasure. Magnification: x80 at 6x7cm size. - Stock Image A610/0157
CHECK OUT THIS INTERESTING INFO FROM THE UC RIVERSIDE WEBSITE...WRITTEN BY the AMAZING ATHLETE JOSH EVERETT! WHAT DAY ARE YOU ON??? Detraining Calendar Days 1 - 2 After last day of training Adrenaline and beta-endorphin levels drop. Your mood is affected negatively, but your body stays intact. Aerobic and power capabilities are the same. Days…
Rabbit polyclonal beta Endorphin antibody validated for ICC/IF and tested in Human, Mouse and Rat. Immunogen corresponding to synthetic peptide
Mouse monoclonal beta Endorphin antibody [B 31.15] validated for IHC and tested in Human and Rat. Referenced in 2 publications. Immunogen corresponding to full…
in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1983), 177(2), 259-68. 5 micrograms of human beta-endorphin were labelled with 2 mCi 125I by the chloramine T technique. After two gel filtrations on Sephadex G-15 and on Sephadex G-50 in phosphate buffer with EDTA, Trasylol ... [more ▼]. 5 micrograms of human beta-endorphin were labelled with 2 mCi 125I by the chloramine T technique. After two gel filtrations on Sephadex G-15 and on Sephadex G-50 in phosphate buffer with EDTA, Trasylol and mercapto-ethanol, a pure tracer was obtained with a specific activity about 150 microCi/ug. Kept at + 4 degrees C, the tracer remained utilizable for 30 days without loss of immunoreactivity. The labelling with lactoperoxydase and the use of another gel filtration method (filtration on Aca 202) gave a 125I beta-END tracer with the same immunoreactivity. The binding of this tracer to the antibody of an anti-beta-END antiserum diluted at 1/8000 was 32% with a non specific binding ...
Sugar is a highly refined substance that does not appear alone in nature. It looks a lot like cocaine, and sugar acts a lot like heroin when it hits the brain. Although the idea that sugar was addictive was controversial among scientists for years, they began to take note when the paper titled Sugar and Fat Bingeing Have Notable Differences in Addictive-Like Behavior was published in the Journal of Nutrition in 2009.. The study showed that sugar affects the brain chemistry and thus might be expected to cause addictive behavior. In the study, written by Nicole Avena and others, it was shown that sugar bingeing can cause withdrawal symptoms and cravings.. The behavioral effects are similar to the neurochemical changes in the brain that also occur with addictive drugs. One finding of that study is seldom discussed - both sugar and the taste of sweet activate beta endorphin receptor sites in the brain, the same receptor sites that are activated by heroin and morphine.. The implications of this ...
Participants will be breast cancer patients receiving radiation therapy at Massachusetts General Hospital. There will be two groups of patients: those receiving adjuvant radiation therapy alone following surgical tumor resection, and those receiving adjuvant chemotherapy and radiation therapy following surgical tumor resection. Patients receiving any radiation regimen detailed below in section 2b are eligible for the study. In this study the investigators will be drawing blood for beta-endorphin measurement prior to, at various times during, and following patients treatment regimens. In addition, at each blood draw, patients will complete questionnaires that assess fatigue, mood, and pain. These questionnaires have all been validated for use in cancer patients (see Procedures Involving Human Participants section below), and for our study, the investigators have formatted them onto computer tablets for ease of patient completion and data analysis. This study will progress as follows:. Patients: ...
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The nature of the genetic defects which define the obese (ob) and diabetes (db) loci in mice remain unknown, but both produce similar syndromes when maintained in the same strain of mice. There is some evidence suggesting a lesion in the central nervous system (CNS) in db/db mice, while ob/ob mice appear to have a primary lesion outside the CNS. In a search for further evidence of a unique central lesion in db/db mice, we have examined neuropeptide content in selected, microdissected brain areas in both of these mutants and lean controls. In order to rule out possible interactions of the db mutation with the genetic background, diabetes mice of both C57BL/KsJ and C57BL/6J strains were studied. When concentrations of nine neuropeptide immunoreactivities were examined in up to seven microdissected areas of the brain, C57BL/6J ob/ob mice showed only one reproducible alteration, a lower content of beta-endorphin-like immunoreactivity (LI) in the preoptic area at both 3 and 6 weeks of age as
The results showed that (1) in the NRM perfuse liquid, pain stimulation could increase the concentrations of AVP, leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), beta-endorphin (beta-Ep), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), but not change the concentrations of dynorphinA(1-13) (DynA(1-13)), oxytocin, achetylcholine, choline, gamma-aminobutyric acid, glutamate, dopamine, 3,4-dihydroxyphenylacetic acid, homovanilic acid, norepinephrine and epinephrine; (2) in the NRM perfuse liquid, AVP increased the concentrations of L-Ek, M-Ek, beta-Ep, DynA(1-13), 5-HT and 5-HIAA, but did not change the concentrations of oxytocin and the other studied neurotransmitters; (3) AVP antinociception in the NRM was attenuated by cypoheptadine (a 5-HT-receptor antagonist) or naloxone (an opiate receptor antagonist), but was not influenced by the other studied receptor antagonists ...
When you are feeling down with the blues and maybe experiencing symptoms of depression, there may be some causes that are not just due to chemical changes in the brain. In fact, there are many things that have been linked to depression. One substance linked to depression is refined sugars which depletes the levels of beta-endorphins in your system. If you are contemplating eliminating refined sugars, you need to keep your blood sugar levels steady. You can do this quite easily if you eat breakfast every morning and eat regular and timely meals each day. Some things you should eat are whole grains, roots, green vegetables, yellow vegetables. The second thing you can do is to improve your levels of serotonin. You can do this by including protein-rich foods, such as beans, cheese, eggs, and meat (including chicken and fish). A few hours after you eat protein you should eat a complex carbohydrate, such as potatoes, corn, yams, or lima beans. These can be eaten cooked, canned, or raw and will help ...
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects ...
Catalyses the cyclisation of the lycopene carotenoid psi-end group into a carotenoid beta-end group in the final step of the synthesis of beta carotene ...
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The variations of plasmatic beta-endorphin and cortisol levels are studied in 3 groups of patients. These subjects are submitted to abdominal surgery following 3 different anaesthetic schemes: neuroleptanalgesia (droperidol and fentanyl), pure analgesia (fentanyl), association halothane - small dose of fentanyl. The study covers the period from premedication through recovery. The results of this work demonstrates that the average level of beta-endorphin in neuroleptanalgesia and pure analgesia series is stable; there is an increase in the halothane series just after the incision until waking up. The average level of cortisol is stable for the 3 series until incision. It is strongly increased in the neuroleptanalgesia series and in the halothane series. This increase is delayed and reduced in the fentanyl series.
There is evidence of release of the opioid peptide beta-endorphin (beta-E) in the hypothalamus during development of fever and stress-induced hyperthermia. In the unanesthetized rabbit microinjection of beta-E in the preoptic/anterior hypothalamus (POAH) results in peripheral vasoconstriction, inhibition of evaporative heat loss, and a prolonged elevation of body temperature. These reactions are magnified with increases in ambient temperature. Injections of beta-E nearly abolish vasodilation to back heating and also postural enhancement of heat dissipation (sprawling, limb extension) in a hot environment. Beta-E has also been found to reduce the thermal sensitivity of single POAH neurons to ambient heating. However, POAH beta-E injections do not alter metabolic rate at ambient temperatures from 2 to 27 C, and to this extent beta-E-induced hyperthermia is distinct from fever. It is suggested that beta-E reduces sensitivity of POAH neurons to high ambient temperature and that this reduction leads ...
Abstract: Neurobiological mechanisms invoking the release of endogenous opioids and depression of stress hormone release are believed to be the basis of acupuncture analgesia. This study compared plasma beta-endorphin and cortisol levels with self assessment scores of intensity of pain, before and after 10 days of electro-acupuncture treatment in patients suffering from chronic pain as a result of osteoarthritis knees. Forty patients of either sex over 40 years with primary osteoarthritis knee were recruited into a single-blinded, sham-controlled study. For electro-acupuncture group the points were selected according to the Traditional Chinese Medicine Meridian Theory. In the sham group needles were inserted at random points away from true acupoints and no current was passed. Both groups were treated for 10 days with one session every day lasting for 20-25min. Pre- and post-treatment Western Ontario and McMaster Universities (WOMAC) index of osteoarthritis knee and Visual Analogue Scale (VAS) ...
Abstract: Neurobiological mechanisms invoking the release of endogenous opioids and depression of stress hormone release are believed to be the basis of acupuncture analgesia. This study compared plasma beta-endorphin and cortisol levels with self assessment scores of intensity of pain, before and after 10 days of electro-acupuncture treatment in patients suffering from chronic pain as a result of osteoarthritis knees. Forty patients of either sex over 40 years with primary osteoarthritis knee were recruited into a single-blinded, sham-controlled study. For electro-acupuncture group the points were selected according to the Traditional Chinese Medicine Meridian Theory. In the sham group needles were inserted at random points away from true acupoints and no current was passed. Both groups were treated for 10 days with one session every day lasting for 20-25min. Pre- and post-treatment Western Ontario and McMaster Universities (WOMAC) index of osteoarthritis knee and Visual Analogue Scale (VAS) ...
Areaumat lavanda stimulates beta endorphin synthesis and inhibits inflammation mediators for a soothing and relaxing effect....Learn more ...
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In the heart of Eagle Ranch Village, Endorphin Eagle Ranch will offer a variety of exercise equipment, workout options and classes to its members. From spin bikes to weightlifting, yoga and Barre classes, the areas only 24-Hour Health Club mixes top-of-the line features with the small-town friendliness that defines Eagle Ranch, and a community that defines Endorphin.. With 5,000 square feet of space, Club members have access to a cardio area that includes stationary bicycles, treadmills, elliptical trainers, circuit training machines and free weights. The separate exercise room, designed for both class use and individual workouts, features a full sound system and 42 monitor. Most cardio equipment includes 15 TV screens.. ...
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if you want to know what structures are available. There once was the thought that an amphipathic helix was required for a particular endorphin to be active, but I havent heard anything about it for years. If you are referring to things like alpha- or beta-endorphin, that has little to do with the structure of the endorphins. These were names given to distinguish the types of endorphins and may reflect nothing more than elution order out of a column or tissue source. Youd probably have to go way back to an old review of the literature to get an explanation of the names, but dont expect there to be much about structure beyond sequence, anyway ...
When you exercise, your body releases chemicals called endorphins. These endorphins interact with the receptors in your brain that reduce your perception of pain. A very large body of scientific evidence shows that people who exercise regularly shows a positive mood and lower rates of depression.There are a number of mechanisms that explain the fact that exercise boost your mood, and one is that of the endorphins. When interacting with the receptors in your brain endorphins trigger a positive feeling in the body, similar to that of morphine.This effect is called runners high, and it is accompanied by a positive approach to the everyday life .Thus, exercise increases your overall health and your sense of well-being, which puts more energy in your step every day.Endorphins act as a sort of analgesics diminishing the perception of pain and as sedatives, producing a feeling of calmness.Regular exercise has multiple positive effects that are been proven to:Reduce stressWard off anxiety and feelings
Another group of non-sex hormones that many people have heard of is the endorphins, which belong to the category of chemicals known as opiates and serve to deaden our pain receptors. Endorphins, which are chemically related to morphine, are produced in response to pain. The natural response to rub an injured area, such as a pinched finger, helps to release endorphins in that area. People who exercise a lot and push their bodies “until it hurts†thereby stimulate the production of endorphins. It is thought that some people who constantly over-exercise and push themselves too much may actually be addicted to their own endorphins which that severe exercise regime releases ...
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Any activity, substance, object, or behavior that has become the major focus of a persons life to the exclusion of other activities, or that has begun to harm the individual or others physically, mentally, or socially is considered an addictive behavior. A person can become addicted, dependent, or compulsively obsessed with anything. Some researchers imply that there are similarities between physical addiction to various chemicals, such as alcohol, and psychological dependence to activities such as sex, work or exercise. It is thought that these behavior activities may produce beta-endorphins in the brain, which makes the person feel high. Some experts suggest that if a person continues to engage in the activity to achieve this feeling of well-being and euphoria, he may get into an addictive cycle. In so doing, he becomes physically addicted to his own brain chemicals, thus leading to continuation of the behavior even though it may have negative health or social consequences. Most physical ...
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My marathon is only three weeks away and right now I need more motivation than ever as I am hitting burnout in training. Luckily, I have reached my taper weeks and race weekend is in sight! The hills of San Francisco are calling my name and I am excited to conquer them. These final weeks I have been looking to different places for motivation. My training buddies have been a huge help along with run club, the Mission Im Possible crew and Hood to Coast teammates. Since I have had to do my last few long runs alone, I have looked to my Endorphin Warrior bracelet for some extra motivation. Endorphin Warrior was kind enough to give all the Nuun Hydration runners a bracelet of their choice. I chose one with the phrase RELENTLESS ...
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The world is moving through challenging times. Sometimes events and circumstances can get heavy. Whilst processing our stuff is positive, wallowing for too long in negativity can be counterproductive. It can create a downward spiral. So how might we keep our heads above water? How might we balance the playing field when were processing density? Well one answer is The Endorphin Effect. Endorphins are chemicals we can produce in our bodies to block negative energy and make us feel positively uplifted and joyful inside. So how do you activate endorphins when needed?...
Street Photography is life; life is Phi. I am an artist with a camera, and I am addicted to the endorphin rush that finding and creating art gives me. We see Phi all around us, we are made of Phi, Phi is the substance of life no matter how it is composed through…
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So my weekends have consisted of studying and food, with a few adventures thrown in. We went to Chicago for a wedding (Congrats Sarah and Rich!) and we also went to a Thousand Foot Krutch concert (awesome, awesome, awesome band!!). Other than that Ive been trying my best to catch up on school and sleep while trying to avoid injuring my foot further. I plan to start swimming tomorrow since I think I have been endorphin deprived for too long. ...
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So Ive been having major issues with this website, so I have moved the blog to: www.endorphinjunkie14.wordpress.com Hope to see you all there! ~Kate ...
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Endorphins are all about fight or flight mechanics - it masks discomfort or pain. This neurotransmitter helps people carry on when they work towards the achievement of distant goals. Endorphins make people feel satisfied and excited.. To trigger endorphin release in the end users brain, UX designers should focus on gaming their designs and make sure to include additional goals. It could be some bonus points for filling out a user profile or connecting to Facebook. By providing extra daily or weekly achievements and challenging users to pursue something meaningful in the constraints of a particular digital product, you will make users feel they have things to do and goals to achieve.. Endorphins introduce a feeling of satisfaction and excitement. The feeling of success often accompanies them, victory, and new achievements. All of these factors trigger endorphin release in the human brain and make people feel better about themselves. It is addictive in a good sense and helps build stronger ...
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So there is another way that your body releases endorphins into your bloodstream that I didnt mention... Stress. I didnt mention before because I dont want everyone running around getting stressed to achieve their natural high, that wont work. But it is true, when we are stressed our body naturally excretes endorphins to try and…
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Anyone got some endorphins to spare me?? I mean - really. I literally *just* posted about all things balance last night, right? Well - today, of course, Im now absolutely craving an endorphin rush. I bet you want to know why, right? How could I be craving that when I had such good intentions for…
Endorphins, theres really no better Rx for a mood-boost than that. Well, except for a pretty awesome husband who always seems to know just what will do the trick to snap me out of a funk. Cute story before I dive into the endorphin convo... I had a pretty bad day yesterday, for numerous reasons…
When we learn to use brain in rhythm to alpha, we are slowing our brainwaves down. The benefit of this is that we put ourselves in the ideal brain state for optimal performance and super learning. We become better at analysing complex situations, learning new information, memorising data, and performing elaborate tasks some forms of meditation, relaxation exercises, and activities that enable a sense of calm, also naturally create this alpha state.. According to neuroscientists, the effect of decreasing the brain rhythm from beta to alpha via deep relaxation techniques and the use of binaural beats brain entrainment, changes the levels of certain beneficial brain chemicals.. Studies show that alpha states significantly increase beta-endorphin, norepinephrine and dopamine. These naturally occurring chemicals are linked to feelings of expanded mental clarity and generate an internal environment for new learning and accessing previously learned information. This positive effect lasts for hours and ...
NSP Community Center indoor track, 16 mi 2:15:23, pace 8:28. This felt like marathon pace today. In fact I think maybe its the pace I will shoot for in the marathon next month, around 8:25 to 8:30. No pains except: (1) a muscle pull or something in my back just above the left hip bone, maybe from going 216 laps in the same direction (thats 864 corners); and (2) some stomach upset later (now). I do have problems with stomach upset after hard runs, especially long ones, but usually not if I dont eat within four hours of the run. In this case it was all night; I ran in the morning with only black coffee for breakfast. Maybe its the gels. I dont much like those, but havent found anything I like better. Otherwise I feel great! Those old endorphins. Mostly five and four-breathing until the last mile. Splits: 8:38, 8:22, 8:38, 8:18, 8:39, 8:25, 8:49, 8:20, 8:40, 8:19, 8:39, 8:17, 8:39, 8:15, 8:43, 7:42. Good last mile; it says there was something left in the tank. Water every two miles, gels at ...
beta-endorphin. 237-267 met-enkephalin. 237-241 In order to regulate the secretion of ACTH, many substances secreted within ...
Bender T, Nagy G, Barna I, Tefner I, Kádas E, Géher P (July 2007). "The effect of physical therapy on beta-endorphin levels". ...
Peniston EG, Kulkosky PJ (April 1989). "Alpha-theta brainwave training and beta-endorphin levels in alcoholics". Alcoholism, ... The work of Barry Sterman, Joel F. Lubar and others has been relevant on the study of beta training, involving the role of ... Beta and SMR training can be considered a more directly physiological approach, strengthening sensorimotor inhibition in the ... This low frequency training differs greatly from the high frequency beta and SMR training that has been practiced for over ...
Smyth, D.G. (2016) Lipotropin & beta-endorphin: a perspective. J. Mol Endocrinol.56, T13-25.. ... A much more potent analgesic than any of the other endorphins … it is also much longer-lived in the brain. This led Dr Smyth to ... Davis, Joel (1984). Endorphins: New Waves in Brain Chemistry. Garden City, New York: Dial Press. pp. 44-45. OCLC 1033595208. ... Smyth, D.G., Smith, C.C.F. and Zakarian, S. (1981) Isolation and identification of two new peptides related to β-endorphin. In ...
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras Endocrinol Metabol (in Portuguese). 52 (4): 589- ... β-endorphin (an endogenous opioid), and phenethylamine (a trace amine and amphetamine analog). Preliminary evidence from a 2012 ...
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras Endocrinol Metabol (in Portuguese). 52 (4): 589- ... β-endorphin (an endogenous opioid), and anandamide (an endogenous cannabinoid). Euphoria can occur as a result of dancing to ... thought to be linked to cerebral β-endorphin activity. The substantial increase in phenylacetic acid excretion in this study ...
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras Endocrinol Metabol (in Portuguese). 52 (4): 589- ... β-Endorphin (contracted from "endogenous morphine") is an endogenous opioid neuropeptide that binds to μ-opioid receptors, in ... A review on β-endorphin and exercise noted that an individual's mood improves for the remainder of the day following physical ...
Role of beta-endorphin and cAMP in addiction and mania. Society for Neuroscience Abstracts. 15:149, 1998. Koob G, Kreek MJ ( ...
"Effect of estetrol on Beta-Endorphin level in female rats". Steroids. 95: 104-10. doi:10.1016/j.steroids.2015.01.003. PMID ... ISSN 1530-0374 Hagen AA, Barr M, Diczfalusy E (June 1965). "Metabolism of 17-beta-oestradiol-4-14-C in early infancy". Acta ... However, animal studies investigating the effects of estetrol on levels of allopregnanolone and β-endorphin in various brain ... effects in some regions of the brain by mediating weak estrogenic effects on the levels of allopregnanolone and β-endorphin ...
The brain's opium: Human beta-endorphins. A. Okasha. Egypt. J. Psychiat. 1979.vol. 2, no. 1, pp 135-137 1980 54. A study of ...
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Cunha GS, Ribeiro JL, Oliveira AR (June 2008). "[Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras ... β-endorphin (an endogenous opioid),[75] and phenethylamine (a trace amine and amphetamine analog).[76][77][78] ...
Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ...
The release of a POMC product, beta-endorphin is regulated by NPY. Centrally projecting neurons that make somatostatin; the ... Proopiomelanocortin (POMC) is a precursor polypeptide that is cleaved into MSH, ACTH, and β-endorphin and expressed in the ... β-endorphin, melanocyte-stimulating hormone (MSH), and somatostatin. ...
Keverne, EB; Martensz, ND; Tuite, B (1989). "Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by ... influences the endocrine system-it appears to be relaxing to those who participate due to the release of beta-endorphin. In ...
Beta-endorphins are found in neurons in the hypothalamus and the pituitary gland. Beta-endorphins are found to be opioid ... Beta- endorphins have been difficult to measure in animal species, differently from oxytocin which can be measured by sampling ... A study in monkeys shows the changes in opiate expression in the body, mirroring changes in beta-endorphin levels, influences ... Grooming stimulates the release of beta-endorphin, which is one physiological reason for why grooming appears to be relaxing. ...
... "increase serum beta-endorphin levels by 44%". Beta-endorphin is associated with feelings of relaxation and euphoria, including ... it also triggers the synthesis of vitamin D and endorphins in the skin. In 1890 the Danish physician Niels Ryberg Finsen ...
Knepel W, Homolka L, Vlaskovska M, Nutto D. (1984). Stimulation of adrenocorticotropin/beta-endorphin release by synthetic ... and beta-endorphin, and melanocyte-stimulating hormone are released under the influence of hypothalamic corticotropin-releasing ...
Levels of beta-endorphin in response to exercise and overtraining]. Arq Bras Endocrinol Metabol. June 2008, 52 (4): 589-598. ...
Koenig JI, Gudelsky GA, Meltzer HY (May 1987). "Stimulation of corticosterone and beta-endorphin secretion in the rat by ... "Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response". Progress in Neuro- ... β-Endorphin secretion may contribute to antidepressant, anxiolytic, and analgesic effects. 5-HT1A receptors can be located on ... Ignarro LJ (June 2008). "Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol". ...
Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and ... beta-Lipotropin at the US National Library of Medicine Medical Subject Headings (MeSH) gamma-Lipotropin at the US National ... In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments of β-lipotropin. β-Lipotropin is the predominant ... Evidence shows that β-Lipotropin is metabolized into endorphins that can greatly affect mood and behavior and is thus regarded ...
"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin". ... β-endorphin). ACTH stimulates the synthesis of cortisol, glucocorticoids, mineralocorticoids and DHEA. In the short term, CRH ...
Sellinger‑Barnette, M. and Weiss, B.: Interaction of betaendorphin and other opioid peptides with calmodulin. Mol. Pharmacol. ... Greenberg, L.H. and Weiss, B.: Beta adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to ... Greenberg, L.H. and Weiss, B.: Ability of aged rats to alter beta-adrenergic receptors of brain in response to repeated ... Weiss, B., Greenberg, L.H. and Cantor, E.: Denervation supersensitivity and beta-adrenergic receptors as a function of age. In ...
... and beta-endorphin". Psychoneuroendocrinology. 20 (5): 499-508. doi:10.1016/0306-4530(94)00077-N. PMID 7675934. S2CID 30375128 ...
... beta-melanocyte stimulating hormone/ beta-endorphin)". Mohamed, F. E. B., Hamza, R. T., Amr, N. H., Youssef, A. M., Kamal, T. M ... β-Endorphin [Met]Enkephalin Although the N-terminal 5 amino acids of β-endorphin are identical to the sequence of [Met] ... β-Endorphin and [Met]enkephalin are endogenous opioid peptides with widespread actions in the brain. The POMC gene is located ... These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin ...
By stimulating beta-endorphin, a hypothalamic and pituitary endogenous peptide, CRH can indirectly alter LH function by acting ... As a result, ACTH is released from the pituitary along with other pro-opiomelanocortin-related peptides such as beta-endorphin ... CRH also stimulates secretion of beta(β)-endorphins, which suppresses release of GnRH and dopamine. Inhibition of dopamine ... of the hypothalamic-pituitary system appears to be manifested through increased secretion of CRH and beta-endorphin by the ...
In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. ...
... resulting in increased levels of epinephrine and beta-endorphin. Its physiological effects stem from the stimulation of ... endorphins. Nicotine interferes with the blood-brain barrier function, and as a consequence raises the risk of brain edema and ... endorphins, and several neuropeptides, including proopiomelanocortin-derived α-MSH and adrenocorticotropic hormone. ...
... resulting in increased levels of adrenaline and beta-endorphin. Its physiological effects stem from the stimulation of ... endorphins, and several neuropeptides. Repeated exposure to nicotine can cause an increase in the number of nicotinic receptors ...
They are found within the pre-BötC and act via alpha-1, alpha-2, and beta-noradrenergic mechanisms.NE induces ICAN-dependent ... These include norepinephrine, serotonin, acetylcholine, substance P, ATP, TRH, somatostatin, dopamine, endorphins, and ...
Massive overdose can be associated with increased sympathetic activity and thus require treatment with beta-blockers.[18] ...
Beta-endorphins (β-endorphins) are the most powerful endorphins in the body. They are usually in the hypothalamus and pituitary ... Four types of endorphins are created in the human body. They are named alpha (α), beta (β), gamma (γ) and sigma (σ) endorphins ... Endorphin rushEdit. The term 'endorphin rush' is sometimes used in normal speech to refer to a feeling of wellness caused by ... Dalayeun JF, Norès JM, Bergal S (1993). "Physiology of beta-endorphins. A close-up view and a review of the literature". ...
Studies suggest that neurotrophic factors have a protective role against amyloid beta toxicity.[85] ...
As IGF2 promotes development of fetal pancreatic beta cells, it is believed to be related to some forms of diabetes mellitus. ...
... or by cross-coupling with beta-amino organozinc reagents, or reacting a brominated arene with beta-aminoethyl organolithium ... thought to be linked to cerebral β-endorphin activity. The substantial increase in phenylacetic acid excretion in this study ... Paulos MA, Tessel RE (February 1982). "Excretion of beta-phenethylamine is elevated in humans after profound stress". Science. ... Suzuki O, Katsumata Y, Oya M (1981). "Oxidation of beta-phenylethylamine by both types of monoamine oxidase: examination of ...
"Super Beta Prostate® - America's #1 Prostate Supplement". www.superbeta.com. Retrieved October 6, 2018.. ... The endorphins had kicked in, and I was not in pain."[21][23] ... Colonial Penn Life Insurance Company and for Super Beta ... "Joe Theismann's Super Beta Prostate Commercial". YouTube. November 3, 2014. Retrieved November 3, 2014.. ...
... (trade name Nimelan), also known as N-allylnormorphine dinicotinate, dinicotinoylnalorphine, or niconalorphine, is a semisynthetic, mixed opioid agonist-antagonist which is described as a narcotic antagonist but may produce limited analgesia and sedation at higher doses in opioid naive patients (with limited euphoria and dependence liability).[1][2] It is the 3,6-dinicotinate ester of nalorphine, and is therefore the nalorphine analogue of nicomorphine (which is the 3,6-dinicotinate ester of morphine). As nalorphine dinicotinate is only regulated at the Rx (prescription required) drug, it would be legal to possess with a valid prescription should a patient manage to acquire it.[citation needed] ...
Transforming growth factor (Beta) Platelets, Kidney, Placenta Inhibitory effect on cultures tumor cell ...
The beta subunits vary. LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is ... Part of the inhibitory action of endorphins on GnRH-1 release is through inhibition of these GABA neurons. Rupture of the ... This beta subunit contains an amino acid sequence that exhibits large homologies with that of the beta subunit of hCG and both ... However, the hCG beta subunit contains an additional 24 amino acids, and the two hormones differ in the composition of their ...
... is a peptide of nine amino acids (a nonapeptide) in the sequence cysteine-tyrosine-isoleucine-glutamine-asparagine-cysteine-proline-leucine-glycine-amide (Cys - Tyr - Ile - Gln - Asn - Cys - Pro - Leu - Gly - NH2, or CYIQNCPLG-NH2); its C-terminus has been converted to a primary amide and a disulfide bridge joins the cysteine moieties.[116] Oxytocin has a molecular mass of 1007 Da, and one international unit (IU) of oxytocin is the equivalent of about 2 μg of pure peptide. While the structure of oxytocin is highly conserved in placental mammals, a novel structure of oxytocin was recently reported in marmosets, tamarins, and other new world primates. Genomic sequencing of the gene for oxytocin revealed a single in-frame mutation (thymine for cytosine) which results in a single amino acid substitution at the 8-position (proline for leucine).[117] Since this original Lee et al. paper, two other laboratories have confirmed Pro8-OT and documented additional oxytocin structural variants in ...
... long peptides such as amyloid beta have been referred to as proteins, and smaller proteins like insulin have been considered ...
... beta-endorphin and prolactin in human adults of both sexes". Alcohol and Alcoholism. 37 (2): 169-73. doi:10.1093/alcalc/37.2. ...
Most involve stimulant-like endorphins and hormones being released in the brain, many of which are those that are 'forced'/' ... Norepinephrine binds to the beta-1 receptor. High blood pressure medications are used to block these receptors and so reduce ... Epinephrine and norepinephrine have similar effects: binding to the beta-1 adrenergic receptors, and opening sodium and calcium ... It also impacts the beta adrenergic response similar to epinephrine and norepinephrine.[11] ...
"Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia". ... The class of endorphins consists of three endogenous opioid peptides: α-endorphin, β-endorphin, and γ-endorphin.[3] α-endorphin ... The endorphin class consists of α-endorphin, β-endorphin, and γ-endorphin. All three preferentially bind to μ-opioid receptors. ... β-endorphin is the primary endorphin released from the pituitary gland. Endorphin binding at μ-receptors inhibits pain signals ...
This effectively blocks the receptor, preventing the body from responding to opioids and endorphins. ...
Collins P, Rosano GM, Sarrel PM, Ulrich L, Adamopoulos S, Beale CM, McNeill JG, Poole-Wilson PA (July 1995). "17 beta-Estradiol ... Wu CH, Motohashi T, Abdel-Rahman HA, Flickinger GL, Mikhail G (August 1976). "Free and protein-bound plasma estradiol-17 beta ... Wu CH, Motohashi T, Abdel-Rahman HA, Flickinger GL, Mikhail G (August 1976). "Free and protein-bound plasma estradiol-17 beta ... Behl C, Widmann M, Trapp T, Holsboer F (November 1995). "17-beta estradiol protects neurons from oxidative stress-induced cell ...
Activators: beta-Hydroxy beta-methylbutyric acid. *Hydroxynorketamine. *Leucine. *NV-5138. *Inhibitors: Rapalogs: Everolimus ...
"Genome-wide binding patterns of thyroid hormone receptor Beta". PLOS One. 9 (2): e81186. Bibcode:2014PLoSO...981186A. doi ...
Off-label prescription of HGH is controversial and may be illegal.[46] Claims for GH as an anti-aging treatment date back to 1990 when the New England Journal of Medicine published a study wherein GH was used to treat 12 men over 60.[47] At the conclusion of the study, all the men showed statistically significant increases in lean body mass and bone mineral density, while the control group did not. The authors of the study noted that these improvements were the opposite of the changes that would normally occur over a 10- to 20-year aging period. Despite the fact the authors at no time claimed that GH had reversed the aging process itself, their results were misinterpreted as indicating that GH is an effective anti-aging agent.[48][49][50] This has led to organizations such as the controversial American Academy of Anti-Aging Medicine promoting the use of this hormone as an "anti-aging agent".[51] A Stanford University School of Medicine meta-analysis of clinical studies on the subject published ...
Relationship between structure and activity of some beta-amino ketones". Journal of Medicinal Chemistry. 12 (6): 994-997. doi: ...
... (INN) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonist-antagonist with opioid antagonist and analgesic properties.[1] It was introduced in 1954[2] and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence.[3] It acts at two opioid receptors - the μ-opioid receptor (MOR) where it has antagonistic effects, and at the κ-opioid receptor (KOR) (Ki = 1.6 nM; EC50 = 483 nM; Emax = 95%) where it exerts high-efficacy partial agonist/near-full agonist characteristics.[4] Nalorphine was the second opioid antagonist to be introduced, preceded by nalodeine (N-allylnorcodeine) in 1915 and followed by naloxone in 1960 and naltrexone in 1963.[2] Due to potent activation of the KOR, nalorphine produces side effects such as dysphoria, anxiety, confusion, and hallucinations, and for this reason, is no longer used medically.[1][2][5] Nalorphine has a number of analogues including niconalorphine (the ...
"Schedules of Controlled Substances: Temporary Placement of Butyryl Fentanyl and Beta-Hydroxythiofentanyl into Schedule I" (PDF) ...
Beta-endorphin. *Alpha-endorphin. *Gamma-endorphin. *α-neo-endorphin. *β-neo-endorphin ... Thymus: Thymosin (Thymosin α1, Thymosin beta) · Thymopoietin · Thymulin Digestive system: Stomach: gastrin · ghrelin · Duodenum ... α (FSH FSHB, LH LHB, TSH TSHB, CGA) · Prolactin · POMC (CLIP, ACTH, MSH, Endorphins, Lipotropin) · GH ...
5-beta THF), reactions for which 5-alpha reductase and 5-beta reductase are the rate-limiting factors, respectively. 5-Beta ... 11-beta HSD1 and 11-beta HSD2. *11-beta HSD1 uses the cofactor NADPH to convert biologically inert cortisone to biologically ... Cortisol is metabolized by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: ... An alteration in 11-beta HSD1 has been suggested to play a role in the pathogenesis of obesity, hypertension, and insulin ...
Beta-Endorphin or β-Endorphin, is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons ... It is one of three endorphins that are produced in humans, the others of which include α-endorphin and γ-endorphin. The amino ... CID 16132316 from PubChem - β-endorphin CID 3081525 from PubChem - β-endorphin (1-9) CID 133304 from PubChem - β-endorphin (2-9 ... Loh HH, Tseng LF, Wei E, Li CH (August 1976). "beta-endorphin is a potent analgesic agent". Proceedings of the National Academy ...
Rabbit polyclonal beta Endorphin antibody validated for ICC/IF and tested in Human, Mouse and Rat. Immunogen corresponding to ... Antiserum to beta Endorphin was raised in rabbits by using the N-terminal portion of bovine beta Endorphin conjugated to ... Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous ... ß-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). ß- ...
beta-endorphin. Natural Childbirth IV: The Hormones of Birth. Learn the important role that hormones play in childbirth, and ...
Mouse monoclonal beta Endorphin antibody [B 31.15] validated for IHC and tested in Human and Rat. Referenced in 2 publications ... Anti-beta Endorphin antibody [B 31.15]. See all beta Endorphin primary antibodies. ... Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous ... ab54205, staining beta Endorphin in anterior (upper) and intermediate (lower) lobes of Wistar rat pituitary gland tissue by ...
Ausgesuchte Qualitäts-Hersteller für beta Endorphin Antikörper. Hier bestellen. ... Monoklonale und polyklonale beta Endorphin Antikörper für viele Methoden. ... anti-beta Endorphin Antikörper (Endorphin beta) Primary Antibody beta-EP Reaktivität: Human IHC (fro), IF, IHC (p) Wirt: Maus ... anti-beta Endorphin Antikörper (Endorphin beta) Primary Antibody beta-EP Reaktivität: Human IHC (fro), IF, IHC (p) Wirt: Maus ...
Endorphins are a group of peptides (small proteins) that occur in the brain. Beta- endorphin is the most active type. Their ... Polarised light micrograph of crystals of beta-endorphin, an opioid peptide that relieves pain. ... Because they are produced by body cells they were named endorphins (endogenous morphines). Besides the nervous system, they ... Beta-endorphin. Polarised light micrograph of crystals of beta-endorphin, an opioid peptide that relieves pain. Endorphins are ...
Compare beta Endorphin ELISA Kits and find the right product on antibodies-online.com. ... Order beta Endorphin ELISA Kits for many Reactivities. Chicken, Cow, Dog and more. ... beta Endorphin ELISA Kit (Endorphin beta) ELISA Kit beta-EP Reactivity: Human Colorimetric Sandwich ELISA 15.6-1000 pg/mL Cell ... beta Endorphin ELISA Kit (Endorphin beta) ELISA Kit beta-EP Reactivity: Rat Colorimetric Competition ELISA 12.35 pg/mL - 1000 ...
Novus Biologicals Beta-endorphin Antibody; Alexa Fluor 594; 0.1 mL ... Beta-endorphin Mouse anti-Human, Alexa Fluor 594, Clone: CLIP/1418, ... beta-endorphin, beta-LPH, beta-melanocyte-stimulating hormone, beta-MSH, CLIP, corticotropin-like intermediary peptide, ... Beta-endorphin Monoclonal antibody specifically detects Beta-endorphin in Human samples. It is validated for Flow Cytometry, ...
What is beta-endorphin? Meaning of beta-endorphin as a finance term. What does beta-endorphin mean in finance? ... Definition of beta-endorphin in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Beta-endorphin financial definition of beta-endorphin https://financial-dictionary.thefreedictionary.com/beta-endorphin ... Related to beta-endorphin: dopamine. Beta. The measure of an assets risk in relation to the market (for example, the S&P500) ...
Compare and order beta Endorphin ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. ... Images for product: Endorphin beta (beta-EP) ELISA Kit Diagramm of the ELISA kit to detect Rat beta -EPwith the optical density ... Images for product: Endorphin beta (beta-EP) ELISA Kit Diagramm of the ELISA kit to detect Rat beta -EPwith the optical density ... Images for product: Endorphin beta (beta-EP) ELISA Kit Diagramm of the ELISA kit to detect Rat beta -EPwith the optical density ...
beta-Endorphin (sheep), 27-L-tyrosine-31-L-glutamic acid- , C158H251N39O46S , CID 16132316 - structure, chemical names, ...
OBJECTIVE: To observe the effects and mechanisms of beta-endorphin (beta-END) preventing collagen induced arthritis (CIA) by ... Yin O, Yu E, Cheng O, Zhang E, Gao A, Lin I, Han I, Zhu I, Beta-endorphin prevents collagen induced arthritis by neuroimmuno- ... RESULTS: Clinical manifestation of rats with CIA were significantly abrogated or ameliorated by treatment with beta-END. Beta- ... CONCLUSION: Beta-END alleviates CIA through both depressing Th1 responses and down-regulating proinflammatory and other ...
... beta-endorphin and prolactin to alcohol-induced dysfunction of pituitary-gonadal axis hormones were studied in adult men and ... In contrast, the decrease in testosterone and increase in beta-endorphin in men suggests that AAI could have an inhibitory ... Effects of acute alcohol intoxication on pituitary-gonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and ... beta-endorphin and prolactin to alcohol-induced dysfunction of pituitary-gonadal axis hormones were studied in adult men and ...
Endorphin beta, 50 µl. ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid ... Antiserum to beta Endorphin was raised in rabbits by using the N-terminal portion of bovine beta Endorphin conjugated to ... Product Description for Endorphin beta. Rabbit anti Endorphin beta.. Presentation: Serum. Product is tested for ... beta-Lipotropin 100%Met-enkephalin 0.01%Leu-enkephalin 0.01%beta-Endorphin 0.01%. Species:. Bovine, Chicken, Feline, Human, ...
... plasma beta-endorphin levels were measured in 31 depressed patients (14 endogenous, 17 nonendogenous) undergoing the ... Plasma levels of beta-endorphin, cortisol, prolactin and growth hormone in depressed patients Acta Psychiatr Scand. 1988 Aug;78 ... These results indicate that measurement of predexamethasone serum cortisol values and plasma IR-beta-endorphin could be ... Basal serum cortisol, growth hormone, prolactin and immunoreactive (IR) plasma beta-endorphin levels were measured in 31 ...
Beta-endorphin Changes in Serum Leptin and Beta Endorphin Levels with Weight Loss by Electroacupuncture and Diet Restriction ... Substance P and Beta Endorphin Mediate Electroacupuncture Induced Analgesic Activity in Mouse Cancer Pain Model Tagged: *Beta- ... This study aims to investigate the role of changes in leptin and beta endorphin (BE) levels in weight loss following ... Changes in Serum Leptin and Beta Endorphin Levels with Weight Loss by Electroacupuncture and Diet Restriction in Obesity ...
Plasma immunoreactive beta-endorphin levels were markedly decreased in the group treated with anti-h beta-endorphin (P less ... antihuman beta-endorphin (anti-h beta-endorphin), or normal rabbit serum. Three hours later all animals were subjected to a ... beta-endorphin, and corticosterone. Rats treated with anti-h beta-endorphin had a survival rate of 64%, which was significantly ... Effects of immune neutralization of corticotropin-releasing hormone, adrenocorticotropin, and beta-endorphin in the surgically ...
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin ... Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin ...
Both [beta]-endorphin and morphine, in a dose dependent manner given intraventricularly suppressed the signs of 14 hour acute ... beta]-Endorphin suppression of acute morphine abstinence in morphine dependent monkeys: Effective given intraventricularly but ... On a molar basis, [beta]-endorphin was more active than morphine in suppressing the signs of morphine abstinence. When given ... Citation: Domino, Edward F., Li, Choh Hao (1985/07)."[beta]-Endorphin suppression of acute morphine abstinence in morphine ...
To examine the effects of low intensity exercise on beta endorphin (β-Ε) levels and urge for alcohol in alcoholic patients. ... Beta Endorphin and Alcohol Urge Responses in Alcoholic Patients Following an Acute Bout of Exercise Athanasios Z Jamurtas1,2*, ... 2014) Beta Endorphin and Alcohol Urge Responses in Alcoholic Patients Following an Acute Bout of Exercise. J Addict Res Ther 5: ... Objective: To examine the effects of low intensity exercise on beta endorphin (β-Ε) levels and urge for alcohol in. alcoholic ...
Blutproben zur Bestimmung von ACTH, beta-Endorphin und Cortisol wurden präoperativ sowie am 1., 3. und 7. postoperativen Tag ... Für den perioperativen Verlauf von beta-Endorphin gab es keine signifikanten Unterschiede. Placebo-Patienten hatten eine ... Cortisol und immunreaktiven Beta-Endorphin sowie die postoperative Infektionsrate bei alkoholkranken Patienten ... Plasma immune reactive beta-endorphine levels did not differ between groups. Placebo patients had a significantly increased ...
... and beta-endorphin-induced antinociception in the mouse. Message Subject (Your Name) has forwarded a page to you from Journal ... and beta-endorphin-induced antinociception in the mouse.. J Y Xu and L F Tseng ... and beta-endorphin-induced antinociception in the mouse.. J Y Xu and L F Tseng ... and beta-endorphin-induced antinociception in the mouse.. J Y Xu and L F Tseng ...
Mabushi area lies between latitudes 9⁰30 N and 9⁰45N and longitudes 8⁰20E and 8⁰35E in the southern part of Kaduna state Nigeria. A Profile of 200m length was established comprising of nine (9) VES Points with a functional Borehole located betweenVESmb3 and VESmb4. The Borehole is one of the oldest in the Area. This study was aimed at characterizing the subsurface structures along the profile taken NE-SW across the functional borehole. The survey area is dominated by mainly four layers, namely: Topsoil, weathered layer, fractured layer and Fresh basement. The topsoil resistivity values varies between 100-1200Ωm. This layer is predominantly sandy clay with an outcrop of granitic rock at VESmb6. The second and third layers within the subsurface structures are taken as the aquifer constituting of sandy soil and coarse/medium grain sand with a relatively large thickness of 65m. The Borehole was sited between VESmb3 and VESmb4. It has been functional for the past twenty nine (29) years. ...
Naloxone effects on beta-endorphin, cortisol, prolactin, growth hormone, HVA and MHPG in plasma of normal volunteers. ... Naloxone effects on beta-endorphin, cortisol, prolactin, growth hormone, HVA and MHPG in plasma of normal volunteers. ... Naloxone effects on beta-endorphin, cortisol, prolactin, growth hormone, HVA and MHPG in plasma of normal volunteers. ...
Differentiation of cells producing poly peptide hormones acth msh lipotropic hormone alpha endorphin beta endorphin growth ... Effects of beta-endorphin fragment 6-31 on morphine- and beta-endorphin-induced growth hormone and prolactin release. European ... Ultrastructural localization of acth beta lipotropin and alpha endorphin and beta endorphin in the porcine anterior pituitary. ... Ultrastructural localization of immuno reactive corticotropin beta lipotropin alpha endorphin and beta endorphin in cells of ...
... beta-endorphin and prolactin in human adolescents of both sexes ... beta-endorphin and prolactin in human adults of both sexes. ... Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin ... Effects of acute alcohol intoxication on pituitary-gonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and ... Effects of acute alcohol intoxication on pituitary-gonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and ...
... what is the role of Beta-endorphin in this addiction? Secondly, prior reviews of research of the effects of opiates and Beta- ... An integration and summarization of research on the effects of opiates, Beta-endorphin and running will answer the following ... Question 2: What implications would running-produced Beta-endorphin have for therapy? ... evidence regarding the existence of running addiction or established causality between this addiction and Beta-endorphin. ...
In both sexes and during both phases of the light cycle rats treated with β-endorphin as infants evidenced a significant ... It was concluded that early exposure to β-endorphin results in permanent changes in behavior perhaps by altering the ... Male and female rat pups were injected with β-endorphin, naloxone or a saline control solution during days 2-7 postnatally. At ... Male and female rat pups were injected with β-endorphin, naloxone or a saline control solution during days 2-7 postnatally. At ...
It is shown that [125I]beta-endorphin is not transported through the BBB, but is rapidly cleaved to free [125I] tyrosine via ... Therefore, chimeric peptide was prepared using [125I] [D-Ala2]beta-endorphin (DABE), owing to the resistance of this analogue ... beta-endorphin, to a transportable peptide vector, e.g. cationized albumin, using disulfide-based coupling reagents such as N- ... beta-endorphin is not transported through the BBB in its unconjugated form, 2) a [125I] DABE-cationized albumin chimeric ...
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  • The effects of acute alcohol intoxication (AAI) on the pituitary-gonadal axis hormones, and the possible contribution of pituitary-adrenal axis hormones, beta-endorphin and prolactin to alcohol-induced dysfunction of pituitary-gonadal axis hormones were studied in adult men and women. (nih.gov)
  • Basal serum cortisol, growth hormone, prolactin and immunoreactive (IR) plasma beta-endorphin levels were measured in 31 depressed patients (14 endogenous, 17 nonendogenous) undergoing the dexamethasone suppression test. (nih.gov)
  • The mean serum prolactin and growth hormone values of these two groups were not significantly different, while plasma IR-beta-endorphin levels of the endogenous group (40.11 +/- 3.57 pg/ml) were significantly lower than those of the nonendogenous group (120.33 +/- 27.98 pg/ml). (nih.gov)
  • The hormones of birth include estrogen and progesterone, oxytocin, beta-endorphins, prolactin and catecholamines (epinephrine/adrenaline and norepinephrine/noradrenaline). (chriskresser.com)
  • Plasma levels of beta-endorphin, prolactin and gonadotropins in male athletes after an international nordic ski race. (unil.ch)
  • β-endorphin and other enkephalins are often released with ACTH to modulate hormone system functioning. (wikipedia.org)
  • Molecular interpretation of ACTH-ß-endorphin coaggregation: relevance to secretory granule biogenesis. (abcam.com)
  • Specific in vivo neutralization was used in an attempt to explore the roles of corticotropin-releasing hormone (CRH), ACTH, and beta-endorphin during surgical stress in Sprague-Dawley rats. (nih.gov)
  • Rats were randomly assigned to groups (n = 20-30/group) that received iv injections of rabbit antirat/human CRH (anti-r/hCRH), antihuman ACTH (anti-hACTH), antihuman beta-endorphin (anti-h beta-endorphin), or normal rabbit serum. (nih.gov)
  • Survival rates were recorded, and RIAs were performed for ACTH, beta-endorphin, and corticosterone. (nih.gov)
  • Anti-r/hCRH had no effect on plasma immunoreactive ACTH or beta-endorphin. (nih.gov)
  • Blutproben zur Bestimmung von ACTH, beta-Endorphin und Cortisol wurden präoperativ sowie am 1. (hu-berlin.de)
  • Blood samples to analyze ACTH, immune reactive beta-endorphine and cortisol were obtained on the morning before intervention and continued on day 1, 3 and 7 after surgery. (hu-berlin.de)
  • In the fetal porcine pituitary ACTH, .beta. (eurekamag.com)
  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically plasma or cerebrospinal fluid) to determine beta-endorphin, an opioid peptide hormone that originates from the same precursor (proopiomelanocortin [POMC]) as adrenocorticotropin (ACTH). (ophthalmologymanagement.com)
  • It had no effect on ACTH or β-endorphin responses in either sex. (phoenixpeptide.com)
  • The hypothalamic-pituitary response to exercise was studied in 12 amenorrheic and in 9 eumenorrheic athletes by comparing the concentrations of corticotropin-releasing hormone (CRH), corticotropin (ACTH), and endorphins (beta-endorphin + beta-lipotropin) in plasma at rest and during an acute exercise on a bicycle ergometer requiring 80% and 100% of the maximal oxygen uptake (VO2 max). (biomedsearch.com)
  • In both groups, significant increases in the response to exercise were found in the concentrations of ACTH and endorphins. (biomedsearch.com)
  • It is concluded that in amenorrheic athletes the capacity of the anterior pituitary to secrete ACTH and endorphins in response to exercise does not significantly differ from that in eumenorrheic athletes, although basal endorphin secretion may be increased. (biomedsearch.com)
  • Immunohistochemistry (Frozen sections) - Anti-beta Endorphin antibody [B 31.15] (ab54205) Image from Ranganathan S et al. (abcam.com)
  • Beta-endorphin Monoclonal antibody specifically detects Beta-endorphin in Human samples. (fishersci.com)
  • Endorphin, Beta (Rat) _ Antibody for Immunohistochemistry _ 50ul antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Endorphin, Beta (Rat) _ Antibody for Immunohistochemistry _ 50ul. (antibody-antibodies.com)
  • Mouse anti Human beta endorphin antibody, clone B31.15 reacts with beta endorphin, a 31 amino acid, opioid neurotransmitter found in the neurons of the central and peripheral nervous system. (bio-rad-antibodies.com)
  • The IL-10 antibody inhibited GW9508-stimulated gene expression of the β-endorphin precursor proopiomelanocortin (POMC) but not IL-10, whereas the β-endorphin antibody did not affect GW9508-stimulated IL-10 or POMC gene expression. (springer.com)
  • Spinal GW9508-induced mechanical antiallodynia was completely blocked by intrathecal minocycline, IL-10 neutralizing antibody, β-endorphin antiserum, and μ-opioid receptor-preferred antagonist naloxone. (springer.com)
  • Melanotropin beta Antibody (CLIP/1. (novusbio.com)
  • We have previously reported abnormal serum and cerebrospinal fluid (CSF) β -endorphin levels in children with the obesity-hypoventilation or Pick-wickian syndrome and improvement in ventilatory status with a narcotic antagonist (intravenous naloxone therapy). (mdedge.com)
  • Plasma and cerebrospinal fluid beta-endorphin concentrations were radioimmunologically assayed in dogs subjected to spinal cord ischemia induced by infrarenal aortic ligature and in control sham-operated dogs. (uniss.it)
  • On the other hand, a significant increase in cerebrospinal fluid beta-endorphin concentration occurred after spinal ischemia, while surgical stress had no significant effect. (uniss.it)
  • Thus, the origins of plasma and cerebrospinal fluid beta-endorphin may be different, with the former secreted from the hypophysis and the latter from nervous tissue. (uniss.it)
  • Observed changes in cerebrospinal fluid beta-endorphin concentration could be related to the ischemic lesion of nervous tissue while the changes in plasma levels may reflect general stressing factors such as the surgery in our experiments. (uniss.it)
  • Low β endorphin level in serum and cerebrospinal fluid (CSF) has been reported in migraine. (phoenixpeptide.com)
  • The first paper was from 1977 and was called " Increased cerebrospinal fluid levels of endorphins after electro-acupuncture . (sciencebasedmedicine.org)
  • Endorphins are a group of peptides (small proteins) that occur in the brain. (sciencephoto.com)
  • Beta-endorphin chimeric peptides: transport through the blood-brain barrier in vivo and cleavage of disulfide linkage by brain. (semanticscholar.org)
  • Chimeric peptides may be transportable through the BBB and are formed by the covalent coupling of a nontransportable peptide, e.g. beta-endorphin, to a transportable peptide vector, e.g. cationized albumin, using disulfide-based coupling reagents such as N-succinimidyl 3-[2-pyridyldithio(propionate)] (SPDP). (semanticscholar.org)
  • Endorphins ( β -endorphin and metenkephalin) are naturally occurring, endogenous peptides with opioid properties and potencies more than ten times that of morphine. (mdedge.com)
  • Early in the 1970s, several small peptides were isolated that appeared to possess natural analgesic properties, and these were collectively termed enkephalins and endorphins . (fsu.edu)
  • The name endorphin, coined by Choh Li of the University of California at Berkeley, refers to "morphine within", and was given to the endogenous morphine-like peptides that also originate from the pituitary hormone. (fsu.edu)
  • Three similar peptides called alpha-, beta-, and gamma-melanocyte stimulating hormones (α-, β-, and γ-MSH) are also cut from the POMC protein. (medlineplus.gov)
  • The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. (nih.gov)
  • Endorphins are endogenous opioid peptides that function as neurotransmitters. (healthtap.com)
  • A significant factor that differentiates β-endorphin from other endogenous opioids is its high affinity for and lasting effect on μ-opioid receptors. (wikipedia.org)
  • Acute traumatic injury engenders the production of beta-endorphin (BE) and other endogenous opioids. (mysciencework.com)
  • Ali Farid M. Ali , Urine fluid beta-endorphin in pelvic schistosomiasis infertility, New Egypt. (who.int)
  • Twenty infertile women with pelvic schistosomiasis and twenty fertile women in the same age group and in the same phase of the menstrual cycle [luteal phase] as a control were enrolled in this work to study the role of uterine fluid beta-endorphin in pelvic schistosomiasis. (who.int)
  • Both [beta]-endorphin and morphine, in a dose dependent manner given intraventricularly suppressed the signs of 14 hour acute morphine abstinence. (umich.edu)
  • On a molar basis, [beta]-endorphin was more active than morphine in suppressing the signs of morphine abstinence. (umich.edu)
  • When given intravenously in much larger doses, [beta]-endorphin was ineffective in contrast to morphine which was effective in suppressing abstinence. (umich.edu)
  • Nitric oxide/cyclic guanosine monophosphate system in the spinal cord differentially modulates intracerebroventricularly administered morphine- and beta-endorphin-induced antinociception in the mouse. (aspetjournals.org)
  • B eta-endorphins , are known to be on par with morphine and have been shown to play a part in relieving stress, pain relief. (unitedremedies.com)
  • The name endorphin comes from the words "endogenous," which means "from the body," and "morphine," which is an opioid pain reliever. (medicalnewstoday.com)
  • Beta-endorphin is similar to the addictive opiates morphine and heroin in that it induces feelings of pleasure, euphoria and dependency. (chriskresser.com)
  • The data suggest that the release of the endogenous substances with morphine-like biological properties, endorphins, is increased by acupuncture stimulation, thus inhibiting pain perception. (sciencebasedmedicine.org)
  • ß-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). (abcam.com)
  • Another peptide produced from POMC is β-endorphin. (medlineplus.gov)
  • Plasma beta-endorphin, cortisol and catecholamines were measured before exercise, during maximal exercise, and 10, 20 and 60 min after exercise. (uni-regensburg.de)
  • The fetal porcine pituitary was studied to detect by means of the immunoperoxidase technique the earliest stages of cells producing polypeptide hormones: .beta. (eurekamag.com)
  • Endorphins are also involved in the release of sex hormones in the pituitary gland. (wikipedia.org)
  • One possible reason for the benefits of acupuncture: Studies show that it causes us to release feel-good hormones, called endorphins, that suppress pain. (sciencebasedmedicine.org)
  • Move on to oxytocin, pouring a small amount of oxytocin, followed by beta-endorphins and alternate between these two hormones pouring small amounts each time. (lamaze.org)
  • Talk about how oxytocin signals the brain to produce beta-endorphins and remind the class that synthetic hormones do not provide this benefit. (lamaze.org)
  • Question 1: Is distance running addictive and if so, what is the role of Beta-endorphin in this addiction? (usu.edu)
  • Therefore, this study endeavored to clarify the role of beta-endorphin (BE) in exercise and immune function. (lsu.edu)
  • Specific, saturable receptors for beta-endorphin were identified on equine lymphocytes which appeared to be a mu/delta receptor complex, with a K$\sb{\rm d}$ of 17 pM and B$\sb{\rm max}$ of 0.538 fmoles/10$\sp6$ cells. (lsu.edu)
  • The following activities show promise as ways to naturally increase endorphins. (medicalnewstoday.com)
  • For example, meditation will increase endorphins as will listening to certain types of music or just relaxing at a quite lake in the mountains. (healthtap.com)
  • During stress, endorphins produce analgesia, which can be blocked by naloxone. (mdedge.com)
  • 2008 ). The specific role of beta-endorphins in analgesia was first established in mice (Loh et al. (springer.com)
  • We conclude that metformin therapy increases PPT in lean PCOS women, without affecting plasma β-endorphin concentration. (phoenixpeptide.com)
  • Studies suggest beta-endorphin increases tolerance to pain and suppresses the immune system , both of which are important during birth. (chriskresser.com)
  • Exercise increases the endorphin release too. (wikipedia.org)
  • Oh, and yes, TENS increases endorphins . (sciencebasedmedicine.org)
  • A 100 mg dose of naltrexone resulted in significant hyperalgesic effects compared to the control participants, confirming that increases in pain threshold in the control group are due to activation of the EOS and release of endorphins during synchronised dancing. (springer.com)
  • 2014 ), and active participation in musical activities increases pain threshold, a common proxy measure of endorphin uptake (Dunbar et al. (springer.com)
  • There was a report in 2014 from an MGH/Harvard team that UV exposure increases beta-endorphin levels in the skin, and that group showed that rodents can apparently become addicted to sunbathing through this effect. (sciencemag.org)
  • PPT and plasma β-endorphin levels were measured in all women at the beginning of the study and after 6 months of observation. (phoenixpeptide.com)
  • β-Endorphin and IL-10 levels were measured in the spinal cord and cultured primary microglia, astrocytes, and neurons. (springer.com)
  • As a load test a veloergometer exercise test was used, and Beta-endorphin (â-EP) levels were measured from venous blood. (edu.pl)
  • Effects of immune neutralization of corticotropin-releasing hormone, adrenocorticotropin, and beta-endorphin in the surgically stressed rat. (nih.gov)
  • Since then, scientists have identified and named five different types of endorphins, all of which occur naturally in the body. (wikipedia.org)
  • Four types of endorphins are created in the human body. (wikipedia.org)
  • At least 20 types of endorphins have been demonstrated in humans. (healthtap.com)
  • The origin of this variable response was investigated by (1) studying the effects of corticotropin-releasing hormone (CRH) on alpha-MSH and NAc beta-end release in vitro, (2) establishing where in the second messenger pathway coupled to CRH receptors melanotrope responsiveness is determined, and (3) testing modulatory actions of other hypothalamic factors (here opioid beta-endorphin). (ru.nl)
  • Plasma corticotropin-releasing hormone, corticotropin, and endorphins at rest and during exercise in eumenorrheic and amenorrheic athletes. (biomedsearch.com)
  • In all cases of suspected or recognized fetal distress, striking elevations of the beta-endorphin concentrations (twofold to 20-fold) were observed. (meta.org)
  • Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. (abcam.com)
  • Neither group showed a significant correlation between plasma IR-beta-endorphin and serum cortisol values. (nih.gov)
  • These results indicate that measurement of predexamethasone serum cortisol values and plasma IR-beta-endorphin could be valuable laboratory tests in the diagnosis of depression. (nih.gov)
  • Pain perception and serum beta-endorphin in trauma patients. (mysciencework.com)
  • We did not observe any significant changes in serum β-endorphin levels in any studied groups during the 6-month observation. (phoenixpeptide.com)
  • β-Endorphin is found in neurons of the hypothalamus, as well as the pituitary gland. (wikipedia.org)
  • ab54205, staining beta Endorphin in anterior (upper) and intermediate (lower) lobes of Wistar rat pituitary gland tissue by Immunohistochemistry (Frozen sections). (abcam.com)
  • Plasma alpha-MSH and acetylated beta-endorphin levels following stress vary according to CRH sensitivity of the pituitary melanotropes in common carp, Cyprinus carpio. (ru.nl)
  • Pituitary melanotropes release alpha-melanocyte-stimulating hormone (alpha-MSH) and acetylated beta-endorphin (NAc beta-end) during stress responses. (ru.nl)
  • We have studied the pain and stress responses to these interventions by measuring changes in the hypothalamic-pituitary-adrenal (HPA) axis and β-endorphin levels. (phoenixpeptide.com)
  • Endorphins are primarily made in the hypothalamus and pituitary glands, though they may come from other parts of the body as well. (medicalnewstoday.com)
  • More endorphins are released in the pituitary gland during times of pain or stress. (wikipedia.org)
  • Endorphins can be found in the pituitary gland, in other parts of the brain, or distributed throughout the nervous system. (healthtap.com)
  • The body has endorphins or endogenous morphines released by the pituitary gland in the brain and act as neurotransmitters in our bodies. (healthtap.com)
  • β-Endorphin in global pathways diffuse to different parts of the body through cerebral spinal fluid in the spinal cord, allowing for β-endorphin release to affect the peripheral nervous system. (wikipedia.org)
  • Double immunofluorescence staining of β-endorphin with glial and neuronal cellular biomarkers was also detected in the spinal cord and cultured primary microglia, astrocytes, and neurons. (springer.com)
  • Massage and hydrotherapy help release endorphins and enkephalins. (fsu.edu)
  • Plasma immunoreactive beta-endorphin levels were markedly decreased in the group treated with anti-h beta-endorphin (P less than 0.0001). (nih.gov)
  • We have previously shown that short-term exposure to ethanol stimulates immunoreactive β-endorphin (IR-β-EP) release from hypothalamic neurons and that chronic ethanol exposure decreases the IR-β-EP release from these neurons. (aspetjournals.org)
  • The first 16 amino acids are identical to α-endorphin. (wikipedia.org)
  • The formation of β-endorphin is then the result of cleavage of the C-terminal region of β-lipotropin, producing a 31 amino acid-long neuropeptide with an alpha-helical secondary structure. (wikipedia.org)
  • A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. (ctdbase.org)
  • α-Endorphin is an endogenous opioid peptide with a length of 16 amino acids, and the amino acid sequence: Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr. (wikipedia.org)
  • Diagramm of the ELISA kit to detect Human beta -EPwith the optical density on the x-axis and the concentration on the y-axis. (antikoerper-online.de)
  • The only significant difference between the groups was a larger mean pre-exercise concentration of endorphins in amenorrheic than in eumenorrheic athletes (4.8 +/- 0.8 standard error [SE] and 2.9 +/- 0.2 pmol/l, respectively). (biomedsearch.com)
  • This sports-science-related article heavily relies on studies that have reported an increase in beta-endorphin (â-EP) concentration in plasma in response to physical activity. (edu.pl)
  • The main function of endorphins is to inhibit the communication of pain signals. (wikipedia.org)
  • abstract = "Beta-endorphin is an endogenous opioid peptide that is released during stress and has been associated with many physiological functions. (elsevier.com)
  • abstract = "To study the possible role of plasma beta-endorphin in bulimia, we measured plasma beta-endorphin immunoreactivity in 34 female patients with normal-weight bulimia and 34 normal female controls matched for weight as percent of ideal. (elsevier.com)
  • Beta-Endorphin or β-Endorphin, is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system. (wikipedia.org)
  • When released into plasma, β-endorphin dampens nociception by binding to opioid receptors on sensory neurons. (uab.edu)
  • Intrathecal GW9508 significantly enhanced IL-10 and β-endorphin immunostaining in spinal microglia and astrocytes but not in neurons. (springer.com)
  • GW9508 also markedly stimulated gene and protein expression of IL-10 and β-endorphin in cultured primary spinal microglia and astrocytes but not in neurons, originated from 1-day-old neonatal rats. (springer.com)
  • Incorporates a vegetable extract that stimulates the production of beta-endorphins. (salermhairproducts.co.uk)
  • Attachment of β-endorphin to proteins in the brain called opioid receptors stimulates signaling for pain relief. (medlineplus.gov)
  • They are named alpha (α), beta (β), gamma (γ) and sigma (σ) endorphins. (wikipedia.org)
  • View a second image of a gamma -endorphin. (fsu.edu)
  • Experiments with mice in anaphylactic shock, due to allergic reactions, show significantly improved survival rates with an injection of gamma -endorphin, but exacerbation of the shock condition when beta -endorphin is injected. (fsu.edu)
  • Alpha endorphins * beta endorphins * gamma endorphins * sigma endorphins * are created in the human body. (healthtap.com)
  • Some progress has been made in finding markers that predict people's genetic predisposition to alcoholism, such as genetic differences in several neurotransmitters, including beta-endorphin and gamma-aminobutryic acid (GABA). (nih.gov)
  • It is one of three endorphins that are produced in humans, the others of which include α-endorphin and γ-endorphin. (wikipedia.org)
  • However, measuring endorphins in humans was not possible until 2008, when new imaging technology became available. (medicalnewstoday.com)
  • Is it possible to create endorphins and then give them to humans or animals, either for medical or research purposes? (healthtap.com)
  • 29 Endorphin beta (beta-EP) ELISA Kits from 5 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • Localized function of β-endorphin results in release of β-endorphin in different brain regions such as the amygdala or the hypothalamus. (wikipedia.org)
  • Neuroregulation by β-endorphin occurs through interference with the function of another neuropeptide, either by direct inhibition of neuropeptide release or induction of a signaling cascade that reduces a neuropeptide's effects. (wikipedia.org)
  • Reports indicate that acute exposure to ethanol leads to an enhanced release of brain β-endorphin (β-E) which through its interaction with μ and δ receptors mediates, at least in part, neurobehavioral effects such as reinforcement and acquisition of ethanol drinking behavior [ 5 ]. (omicsonline.org)
  • 1, 2 Release of endorphins results in neurotransmitter and neuroendocrine effects in the central nervous system. (mdedge.com)
  • Relative rates of alpha-MSH and NAc beta-end release following stimulation with CRH in vitro match plasma level changes in vivo, and this indicates that the CRH pathway does act in vivo. (ru.nl)
  • Opioid beta-endorphin differentially modulated the actions of CRH, as NAc beta-end, but not alpha-MSH, release was inhibited. (ru.nl)
  • They found an increase in the release of endorphins after exercise. (medicalnewstoday.com)
  • [4] Also, scientists think that acupuncture results in the release of more endorphins. (wikipedia.org)
  • It is commonly said that the "high" is a result of the release of bigger amounts of endorphins in the body during the exercise. (wikipedia.org)
  • However, some scientists think this feeling is caused by the challenge , and is not related to endorphin release. (wikipedia.org)
  • it means this feeling is not caused by the release of endorphins in the blood. (wikipedia.org)
  • We hypothesized that the heme-dependent redox signaling induces ER stress, which attenuates leukocyte β-endorphins levels/release, thereby increasing pain sensitivity in people with HIV. (uab.edu)
  • It is always ELECTRO acupuncture that sometimes results in an endorphin release. (sciencebasedmedicine.org)
  • I am a birth educator as well as a birth doula and came across your blog regarding endorphin release this week. (blogspot.com)
  • Does singing release endorphins? (healthtap.com)
  • What causes the release of endorphins in the body? (healthtap.com)
  • What could cause someone's body to not release endorphins? (healthtap.com)
  • Beta-endorphin release plays an important role in the analgesic effect of both calcitonin and raloxifene. (elsevier.com)
  • Conclusions: Although high-dose pamidronate therapy does mitigate pain substantially (as demonstrated by the reduction of VAS scores), its analgesic action is probably unrelated to the enhancement of beta-endorphin release. (elsevier.com)
  • Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain. (edu.pl)
  • Endorphins, a class of neurohormones, act by modifying the way in which nerve cells respond to transmitters and are associated with feelings of pain and pleasure. (fsu.edu)
  • Endorphins are among the brain chemicals known as neurotransmitters, which function to transmit electrical signals within the nervous system. (healthtap.com)
  • Clinical manifestation of rats with CIA were significantly abrogated or ameliorated by treatment with beta-END. (nel.edu)
  • Plasma beta-endorphin levels rose significantly following surgery in control dogs but were unaffected by spinal ischemia. (uniss.it)
  • The Melanotropin beta gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. (novusbio.com)
  • The time course of plasma cortisol levels exhibited the same pattern as beta-endorphins with the same significant differences between symptomatic and asymptomatic groups. (uni-regensburg.de)
  • The variations of plasmatic beta-endorphin and cortisol levels are studied in 3 groups of patients. (semanticscholar.org)
  • Beta-endorphin and metenkephalin stimulate human peripheral blood mononuclear cell chemotaxis. (springer.com)
  • Global function of β-endorphin is related to decreasing bodily stress and maintaining homeostasis resulting in pain management, reward effects, and behavioral stability. (wikipedia.org)
  • Polarised light micrograph of crystals of beta-endorphin, an opioid peptide that relieves pain. (sciencephoto.com)
  • As beta-endorphin levels rose, so did the mice's ability to withstand pain. (thefreedictionary.com)
  • The basis of pain relief in migraine by repetitive transcranial magnetic stimulation (rTMS) may be related to β endorphin (BE), which has not been evaluated. (phoenixpeptide.com)
  • Endorphins are chemicals produced naturally by the nervous system to cope with pain or stress. (medicalnewstoday.com)
  • Endorphins are chemicals that help to relieve pain or stress, and boost happiness. (medicalnewstoday.com)
  • Endorphins are chemicals produced by the body to relieve stress and pain. (medicalnewstoday.com)
  • Natural endorphins work similarly to opioid pain relievers, but their results may not be as dramatic. (medicalnewstoday.com)
  • High levels of beta-endorphin help the mother to tolerate the pain of labor and nudge her into the altered state of consciousness that characterizes an undisturbed birth. (chriskresser.com)
  • Endorphins are natural chemicals in the body that fight pain . (wikipedia.org)
  • In addition to blocking pain, endorphins can make people happy. (wikipedia.org)
  • I have never bothered to go back and see what the original literature was to support endorphins as a potential mechanism for a beneficial effect of acupuncture on pain. (sciencebasedmedicine.org)
  • Do low level endorphins reduce the feeling of pain? (thenakedscientists.com)
  • We conducted a double-blind administration of placebo and naltrexone (an endorphin antagonist) before groups of strangers danced in synchrony and measured both pain threshold and sense of belonging to the group after dancing. (springer.com)
  • Endorphins are released with any pain irrespective of severity. (healthtap.com)
  • The purpose of the study was to identify the relationship between plasma β-endorphin (objective variable) and the dimensions of the Chinese Cancer Pain Assessment Tool (CCPAT) (subjective variables). (eduhk.hk)
  • The importance of psychosocial, emotional and intensity factors in assessment of pain is re-affirmed by this study using β-endorphin as a biological benchmarker. (eduhk.hk)
  • Materials & Methods: Visual analog scale (VAS) scores of pain intensity, beta-endorphin levels, and alkaline phosphatase activity of 11 patients with Paget's disease (7 with the mono- and 4 with the polyostotic form) were determined at baseline, as well as after 3 and 6 infusions (on Days 6 and 12 of treatment, respectively). (elsevier.com)
  • This study aimed to elucidate the mechanisms underlying GPR40 activation-induced antinociception in neuropathic pain, particularly related to the spinal glial expression of IL-10 and subsequent β-endorphin. (springer.com)
  • After the conflict, the beta-endorphin deficient mice had higher corticosterone levels but the peak increase in body temperature was not different from that in wild type animals. (elsevier.com)
  • CCPAT scores and venous blood for β-endorphin were taken from each subject concurrently on two occasions, 8 a.m. and 8 p.m. (eduhk.hk)
  • Beta endorphin and Met enkephalin are endogenous opiates. (acris-antibodies.com)
  • An integration and summarization of research on the effects of opiates, Beta-endorphin and running will answer the following question, or indicate where evidence is insufficient and explore avenues that require further research. (usu.edu)
  • Secondly, prior reviews of research of the effects of opiates and Beta-endorphin on psychopathological illnesses will be combined with research on both running as a therapeutic tool and its impact on personality. (usu.edu)
  • Discover related pathways, diseases and genes to Melanotropin beta. (novusbio.com)
  • After the baby has been born, beta-endorphin (like oxytocin) reinforces the mother-infant bond and contributes to ecstatic feelings for both. (chriskresser.com)
  • We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. (pnas.org)
  • However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). (pnas.org)
  • We show that each neuropeptide is quite specific in its domain of influence, although endorphins and dopamine influence all three social domains. (pnas.org)
  • Antiserum to beta Endorphin was raised in rabbits by using the N-terminal portion of bovine beta Endorphin conjugated to thyroglobulin. (acris-antibodies.com)
  • β-Endorphin has the highest binding affinity of any endogenous opioid for the μ-opioid receptor. (wikipedia.org)
  • Acytelation of the N-terminus of β-endorphin, however, inactivates the neuropeptide, preventing it from binding to its receptor. (wikipedia.org)