beta-Endorphin: A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.Endorphins: One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.beta-Lipotropin: A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Melanocyte-Stimulating Hormones: Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS OF HYPOTHALAMUS.Pituitary Hormones, Anterior: Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Structurally, they include polypeptide, protein, and glycoprotein molecules.Pro-Opiomelanocortin: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).N-Terminal Acetyltransferases: Enzymes that catalyze the transfer of an acetyl group, usually from ACETYL COENZYME A, to the N-terminus of a peptide chain.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).BostonMassachusettsCaregivers: Persons who provide care to those who need supervision or assistance in illness or disability. They may provide the care in the home, in a hospital, or in an institution. Although caregivers include trained medical, nursing, and other health personnel, the concept also refers to parents, spouses, or other family members, friends, members of the clergy, teachers, social workers, fellow patients.Hospitals, General: Large hospitals with a resident medical staff which provides continuous care to maternity, surgical and medical patients.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Foreign-Body Reaction: Chronic inflammation and granuloma formation around irritating foreign bodies.Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.Pleasure: Sensation of enjoyment or gratification.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Electroacupuncture: A form of acupuncture with electrical impulses passing through the needles to stimulate NERVE TISSUE. It can be used for ANALGESIA; ANESTHESIA; REHABILITATION; and treatment for diseases.Weight Loss: Decrease in existing BODY WEIGHT.Leptin: A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.Acupuncture Points: Designated locations along nerves or organ meridians for inserting acupuncture needles.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)Wernicke Encephalopathy: An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)Ethanol: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.Alcohol Amnestic Disorder: A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Surgical Wound Infection: Infection occurring at the site of a surgical incision.Liver Diseases, Alcoholic: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.Pituitary Apoplexy: The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.Biometric Identification: A method of differentiating individuals based on the analysis of qualitative or quantitative biological traits or patterns. This process which has applications in forensics and identity theft prevention includes DNA profiles or DNA fingerprints, hand fingerprints, automated facial recognition, iris scan, hand geometry, retinal scan, vascular patterns, automated voice pattern recognition, and ultrasound of fingers.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Aldehyde Dehydrogenase: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Receptors, Opioid: Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.Carps: Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.alpha-MSH: A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.Kinetoplastida: An order of flagellate protozoa. Characteristics include the presence of one or two flagella arising from a depression in the cell body and a single mitochondrion that extends the length of the body.Corticotropin-Releasing Hormone: A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.Protozoan Infections, Animal: Infections with unicellular organisms formerly members of the subkingdom Protozoa. The infections may be experimental or veterinary.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Spinal Cord Ischemia: Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.

Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study. (1/492)

OBJECTIVES: The purpose of this study was to test whether cutaneous thermal pain thresholds are related to anginal pain perception. BACKGROUND: Few ischemic episodes are associated with angina; symptoms have been related to pain perception thresholds. METHODS: A total of 196 patients with documented coronary artery disease underwent bicycle exercise testing and thermal pain testing. The Marstock test of cutaneous sensory perception was administered at baseline after 30 min of rest on two days and after exercise and mental stress. Resting hot pain thresholds (HPTs) were averaged for the two baseline visits and divided into two groups: 1) average HPT <41 degrees C, and 2) average HPT > or =41 degrees C, to be clearly indicative of abnormal hypersensitivity to noxious heat. RESULTS: Patients with HPT <41 degrees C had significantly shorter time to angina onset on exercise testing than patients with HPT > or =41 degrees C (p < 0.04, log-rank test). Heart rates, systolic blood pressure and rate-pressure product at peak exercise were not different for the two groups. Resting plasma beta-endorphin levels were significantly higher in the HPT <41 degrees C group (5.9+/-3.7 pmol/liter vs. 4.7+/-2.8 pmol/liter, p = 0.02). Using a Cox proportional hazards model, patients with HPT <41 degrees C had an increased risk of angina (p = 0.03, rate ratio = 2.0). These differences persisted after adjustment for age, gender, depression, anxiety and history of diabetes or hypertension (p < 0.01). CONCLUSIONS: Occurrence of angina and timing of angina onset on an exercise test are related to overall hot pain sensory perception. The mechanism of this relationship requires further study.  (+info)

Enhancing effects of beta-endorphin on glutamate neurotoxicity. (2/492)

AIM: To study the effect of beta-endorphin (beta-End) on monosodium glutamate (MSG)-induced neurotoxicity (GNT). METHODS: Image analysis of neuronal areas and determination of mitochondrial membrane protein-bound Ca2+ and intracellular free Ca2+ ([Ca2+]i) were used. RESULTS: beta-End aggravated MSG-induced neuronal injury in arcuate nucleus of hypothalamus in a dose-dependent manner in the range from 0.5 to 5.0 mg.kg-1. MSG-induced increase in mitochondrial membrane protein-bound Ca2+ was enhanced when treated with beta-End 2 g.L-1. MSG-induced elevation in [Ca2+]i in single neuron was also augmented from 320 +/- 84 to 589 +/- 78 nmol.L-1 by the treatment with beta-End 2 g.L-1. CONCLUSION: beta-End enhanced GNT via aggravating the disruption of intracellular Ca2+ homeostasis induced by MSG.  (+info)

Physiological changes in Pachinko players; beta-endorphin, catecholamines, immune system substances and heart rate. (3/492)

Pachinko is a popular form of recreation in Japan. However, in recent years, along with Pachinko's popularity, "Pachinko dependence" has become topical news. The purpose of this study was to investigate beta-endorphin, catecholamines, immune system responses and heart rate during the playing of Pachinko. The following significant results were observed. (1) Plasma concentration of beta-endorphin increased before playing Pachinko and while in the Pachinko-center (p < 0.05). (2) Beta-endorphin and norepinephrine increased when the player began to win (i.e. at "Fever-start") compared to baseline (p < 0.05). (3) Beta-endorphin, norepinephrine and dopamine increased when the winning streak finished (i.e. at "Fever-end") compared to baseline (p < 0.05-0.01). (4) Norepinephrine increased past 30 minutes after "Fever-end" compared to baseline (p < 0.05). (5) Heart rate increased before "Fever-start" compared to baseline, peaked at "Fever-start" and rapidly decreased to match rates measured at rest. But the increase was observed from 200 seconds after "Fever-start" (p < 0.05-0.001). (6) There was a positive correlation between the number of hours subjects played Pachinko in a week and the differences between beta-endorphin levels at "Fever-start" and those at rest (p < 0.05). (7) The number of T-cells decreased while the number of NK cells increased at "Fever-start" compared to baseline (p < .05). These results suggest that intracerebral substances such as beta-endorphin and dopamine are involved in the habit-forming behavior associated with Pachinko.  (+info)

Effect of raised plasma beta endorphin concentrations on peripheral pain and angina thresholds in patients with stable angina. (4/492)

OBJECTIVE: To determine whether changes in plasma concentrations of beta endorphins alter angina threshold and peripheral pain threshold in patients with stable angina. DESIGN: Latin square design comparison of angina thresholds by exercise treadmill test and peripheral pain thresholds using a radiant heat source in eight patients with stable angina under control conditions, after stimulation of pituitary beta endorphin release by ketoconazole, after suppression of pituitary beta endorphin release by dexamethasone, and after blockade of opioid receptors by intravenous naloxone. RESULTS: An approximately fivefold increase in circulating concentrations of beta endorphins was found after administration of ketoconazole (mean (SEM): 13.9 (1.2) v 73.8 (6.2) pg/ml; p < 0.05), which was associated with an increase in peripheral pain threshold to a radiant heat source (time to onset of pain perception 72 (19) v 123 (40) seconds; p < 0.05), but no significant difference in angina threshold. A reduction in circulating concentrations of beta endorphins after pretreatment with dexamethasone was statistically non-significant (13.9 (1.2) v 9.0 (1.5) pg/ml; NS) and was not associated with any change in either peripheral pain or angina thresholds. No effects were seen after blockade of opioid receptors by previous administration of intravenous naloxone. CONCLUSIONS: Increased plasma concentrations of beta endorphins alter peripheral pain threshold but not angina threshold in patients with stable angina pectoris.  (+info)

The interaction of bioactive peptides with an immobilized phosphatidylcholine monolayer. (5/492)

The interaction of three bioactive peptides, bombesin, beta-endorphin, and glucagon with a phosphatidylcholine monolayer that was immobilized to porous silica particles and packed into a stainless steel column cartridge, has been studied using dynamic elution techniques. This immobilized lipid monolayer provides a biophysical model system with which to study the binding of peptides to a lipid membrane. In particular, the influence of temperature and methanol concentration on the affinity of each peptide for the immobilized lipid surface was assessed. For all test peptides, nonlinear retention plots were observed at all temperatures that contrasted sharply with the simple linear plots observed for the small unstructured control molecules N-acetyltryptophanamide and diphenylalanine. An analysis of the thermodynamics of the interaction of peptides with the immobilized monolayer was also carried out. The results revealed that while the peptides interacted with the monolayer predominantly through hydrophobic interactions, the relative contribution of DeltaH(assoc)(O) and DeltaS(assoc)(O) to the overall free energy of association was dependent on the temperature and methanol concentration. In particular, it was evident that under most conditions, the binding of the peptides to the immobilized lipid monolayer was enthalpy-driven, i.e., mediated by nonclassical hydrophobic interactions. Significant band-broadening and asymmetric and split peaks were also observed for bombesin, beta-endorphin, and glucagon at different temperatures and methanol concentrations. These changes in affinity and peak shape are consistent with the formation of multiple conformational species during the interaction of these peptides with the lipid monolayer. In addition, the binding behavior of the three test peptides on an n-octylsilica surface that lacked the phospho headgroups of the phospholipid was significantly different from that observed with the immobilized phosphatidylcholine surface, indicating a specificity of interaction between the peptides and the lipid surface. Overall, these experimental results demonstrate that the biomimetic phosphatidylcholine monolayer provides a stable and sensitive system with which to explore the molecular mechanism of peptide conformational changes during membrane interactions.  (+info)

The stress response of the gilthead sea bream (Sparus aurata L.) to air exposure and confinement. (6/492)

We investigated short-term effects (up to 24 h) of air exposure and confinement, and long-term effects (up to 11 days) of confinement, to elucidate signalling pathways in the stress response of gilthead sea bream Sparus aurata L. Plasma glucose and lactate were taken as indicators of sympathetic activation, and alpha-melanocyte stimulating hormone (alpha-MSH), adrenocorticotrophic hormone (ACTH) and cortisol as indicators of activation of the brain-pituitary-interrenal (BPI) axis. Air exposure for 3 min resulted, within 30 min, in an increase in plasma concentrations of cortisol, alpha-MSH, glucose, lactate, osmolality and plasma Na, Cl and Mg. Plasma ACTH and beta-endorphin and plasma K, Ca and P did not change. We conclude that air exposure mainly activates the brain-sympathetic-chromaffin cell (BSC) axis. In fish confined at a density of 70 kg/m(3) (compared with 4 kg/m(3) in controls), cortisol, ACTH and alpha-MSH increased within 1 h, indicating activation of the BPI axis. Plasma glucose, Na, Cl and Mg increased with an 8 h delay compared with the response to air exposure. No changes in plasma lactate, osmolality, K, Ca and P were observed. Long-term confinement induced a biphasic cortisol response with peaks at 1 h and at 2 and 3 days. A gradual increase in plasma beta-endorphin concentrations peaked at 7 days; the concentration of alpha-MSH increased rapidly within 1 h and then declined to control values 4 days after the onset of confinement. No changes in ACTH were detected. Our data provide evidence that a stressor-specific activation of the BSC and BPI axes may occur in Sparus aurata.  (+info)

Strenuous resistive breathing induces proinflammatory cytokines and stimulates the HPA axis in humans. (7/492)

Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), powerful stimulants of the hypothalamic-pituitary-adrenal (HPA) axis, increase in response to whole body exercise. Strenuous inspiratory resistive breathing (IRB), a form of clinically relevant "exercise" for the respiratory muscles, produces beta-endorphin through a largely unknown mechanism. We investigated (in 11 healthy humans) whether strenuous IRB produces proinflammatory cytokines and beta-endorphin in parallel with stimulation of the HPA axis, assessed by concurrent measurement of ACTH. Subjects underwent either severe [at 75% of maximal inspiratory pressure (P(m) (max))] or moderate (at 35% of P(m) (max)) IRB. Plasma cytokines, beta-endorphin, and ACTH were measured at rest (point R), at the point at which the resistive load could not be sustained (point F), and at exhaustion [15 min later (point E)]. During severe IRB, IL-1beta increased from 0.83 +/- 0.12 pg/ml at point R to 1.88 +/- 0. 53 and 4.06 +/- 1.27 pg/ml at points F and E, respectively (P < 0. 01). IL-6 increased from 5.30 +/- 1.02 to 10.33 +/- 2.14 and 11.66 +/- 2.29 pg/ml at points F and E, respectively (P = 0.02). ACTH and beta-endorphin fluctuated from 20.87 +/- 5.49 and 25.03 +/- 3.97 pg/ml at point R to 22.97 +/- 4.41 and 26.32 +/- 3.93 pg/ml, respectively, at point F and increased to 46.96 +/- 8.55 and 40.32 +/- 5.94 pg/ml, respectively, at point E (P < 0.01, point E vs. point F). There was a positive correlation between the IL-6 at point F and the ACTH and beta-endorphin at point E (r = 0.88 and 0.94, respectively; P < 0.01) as well as between the increase in IL-6 (between points R and F) and the increases in ACTH and beta-endorphin (between points F and E, r = 0.91 and 0.92, respectively; P < 0.01). Moderate IRB did not produce any change. We conclude that severe IRB produces proinflammatory cytokines and stimulates the HPA axis in humans secondary to the production of cytokines (especially IL-6).  (+info)

Localization of pro-opiomelanocortin mRNA transcripts and peptide immunoreactivity in rat heart. (8/492)

OBJECTIVE: alpha-Melanocyte-stimulating hormone (alpha-MSH), beta-endorphin and other pro-opiomelanocortin-(POMC) derived peptides have been detected in the heart, but it is uncertain whether they are synthesized by cardiomyocytes or by cardiac nerves innervating the heart. The objective of this study was to determine whether POMC peptides are synthesized by cardiomyocytes. METHODS: Pro-opiomelanocortin peptides were localized in rat heart by immunohistochemistry using antisera against alpha-MSH, beta-endorphin and alpha N-acetyl-beta-endorphin, the predominant POMC peptides found in heart. Pro-opiomelanocortin mRNA was investigated by reverse transcription polymerase chain reaction (RT-PCR) using primers that discriminate between full-length POMC mRNA and a 5' truncated POMC transcript that is presumed to be non-functional. RESULTS: alpha-Melanocyte-stimulating hormone, beta-endorphin and alpha N-acetyl-beta-endorphin immunoreactivities were localized in atrial myocytes, particularly in the atrial appendages, but not to a significant extent in ventricular myocytes. Cardiac nerves were not immunostained. Atrial natriuretic peptide (ANP) immunoreactivity was similarly distributed in the adult heart. In neonatal heart, POMC-peptide and ANP immunoreactivities were present in both atrial and ventricular myocytes. RT-PCR amplification showed that full-length POMC mRNA transcripts were present in both atrial and ventricular tissue and provide evidence that 5' truncated POMC mRNA is expressed in heart. CONCLUSIONS: These results support the hypothesis that cardiomyocytes synthesize POMC peptides.  (+info)

Plasma and cerebrospinal fluid beta-endorphin concentrations were radioimmunologically assayed in dogs subjected to spinal cord ischemia induced by infrarenal aortic ligature and in control sham-operated dogs. Plasma beta-endorphin levels rose significantly following surgery in control dogs but were unaffected by spinal ischemia. On the other hand, a significant increase in cerebrospinal fluid beta-endorphin concentration occurred after spinal ischemia, while surgical stress had no significant effect. Thus, the origins of plasma and cerebrospinal fluid beta-endorphin may be different, with the former secreted from the hypophysis and the latter from nervous tissue. Observed changes in cerebrospinal fluid beta-endorphin concentration could be related to the ischemic lesion of nervous tissue while the changes in plasma levels may reflect general stressing factors such as the surgery in our experiments. ...
Pituitary melanotropes release alpha-melanocyte-stimulating hormone (alpha-MSH) and acetylated beta-endorphin (NAc beta-end) during stress responses. However, effects of stressors on plasma concentrations of these hormones are highly inconsistent among fish species. Here, we show that also within a species, the common carp (Cyprinus carpio), fish sometimes respond with elevated alpha-MSH and NAc beta-end plasma levels, and at other times not. The origin of this variable response was investigated by (1) studying the effects of corticotropin-releasing hormone (CRH) on alpha-MSH and NAc beta-end release in vitro, (2) establishing where in the second messenger pathway coupled to CRH receptors melanotrope responsiveness is determined, and (3) testing modulatory actions of other hypothalamic factors (here opioid beta-endorphin). Melanotropes were in a high or low responsive state to CRH in vitro, which was especially evident when tissue was tested from fish kept at higher ambient water temperatures, ...
The opiate antagonist, naloxone, was shown to attenuate the analgesic effect of N2O in mice [1] and subsequently in humans, [2] which led the authors to speculate that opiate receptors mediated the analgesic effect of N2O. However, the dose used (5.0 mg [dot] kg sup -1 in mice) was much larger than the dose required to block responses to exogenously administered opiate narcotics. This may be important because naloxone itself can exert a hyperalgesic effect at high doses. [17] Using smaller doses of naloxone, other investigators have demonstrated a mild enhancing, [18] a mild attenuating, [19] or no effect [20] on N2O analgesia in humans. Later studies showed that plasma beta endorphin concentrations and [Met5]enkephalin [21] concentrations in the cerebrospinal fluid increase after N2O exposure; however, neither the [Met5]enkephalin [4] nor the endorphin [5,6] findings could be corroborated. Subsequent studies revealed that N2O increased beta-endorphin concentrations along the arcuate ...
Very few clinical trials have been produced to provide evidence that manipulative treatment by chiropractors is beneficial to patients with neck pain. The senior author of this study, Howard T. Vernon, conducted clinical analog studies in which the results of a single manipulation were compared to control procedures. In the first study, a single thoracic manipulation produced a significantly higher rise in cutaneous pain tolerance levels than the shashared/stockpages/cp/conditions/neckpain/m/manipulation group. In the second study, a single manipulation of the cervical spine produced a modest increase in plasma beta-endorphin levels while control and sham procedures dropped. These studies support the idea that pain relief occurs subsequent to manipulation, and to the theory that this pain relief is a result of reflex mechanisms activated by the thrust. The reflex mechanisms can be described as afferent bombardment from the articular and myofascial receptors which produces pre synaptic inhibition ...
This paper outlines the many components of the mammalian immune system and the anatomical and physiological connections suggesting that the nerve system plays a role in the modulation of immune response. The few studies attempting to measure the effect of chiropractic or manipulative treatment on the immune system are reviewed. Their results suggest that chiropractic or manipulative treatment may influence T and B lymphocyte numbers, NK cell numbers, antibody levels, phagocytic activity and plasma beta-endorphin levels. The influence of these effects on the outcome of host resistance is unknown. There is now a need for large, well-planned clinical trials using some of the more sophisticated measures of immune function to establish whether chiropractic treatment can influence the immune response in a clinically significant manner. ...
This paper outlines the many components of the mammalian immune system and the anatomical and physiological connections suggesting that the nerve system plays a role in the modulation of immune response. The few studies attempting to measure the effect of chiropractic or manipulative treatment on the immune system are reviewed. Their results suggest that chiropractic or manipulative treatment may influence T and B lymphocyte numbers, NK cell numbers, antibody levels, phagocytic activity and plasma beta-endorphin levels. The influence of these effects on the outcome of host resistance is unknown. There is now a need for large, well-planned clinical trials using some of the more sophisticated measures of immune function to establish whether chiropractic treatment can influence the immune response in a clinically significant manner. ...
Current evidence suggests that endogenous opioids are released in response to various stressors and that these opioids interact with cells of the immune system, and modulate immune function. However, data substantiating this are conflicting. Therefore, this study endeavored to clarify the role of beta-endorphin (BE) in exercise and immune function. Beta-endorphin exhibited a diurnal rhythm in the horse with peak plasma levels occurring at 0900 hours. Analgesia, tachycardia and mydriasis were also observed at this time, mimicking the effects of morphine in the horse. Therefore, subsequent experiments were performed at 0900 hours during times of increased basal opioid activity. Beta-endorphin levels were increased in response to maximal exercise in the horse. The BE response to exercise was attenuated by physical conditioning and was correlated with exercise intensity. Analgesia was noted in unfit horses but not in fit horses after a standardized exercise bout, suggesting that unfit horses experience
Changes in Serum Leptin and Beta Endorphin Levels with Weight Loss by Electroacupuncture and Diet Restriction in Obesity Treatment. This study aims to investigate the role of changes in leptin and beta endorphin (BE) levels in weight loss following electroacupuncture (EA) application in obesity treatment. EA was applied to 20.... ...
Definition of beta-endorphin in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is beta-endorphin? Meaning of beta-endorphin as a finance term. What does beta-endorphin mean in finance?
2) "The endogenous opioids seem likely to be assigned a significant role in the integrated hormonal and metabolic response to exercise. This article reviews the present evidence on exercise and the endogenous opioids, and examines their involvement in a number of widely disparate physiological processes. In considering the role of individual opioid peptides, it is important to remember that many of the tools and techniques now used are still relatively crude. Most studies have demonstrated that serum concentrations of endogenous opioids, in particular beta-endorphin and beta-lipotrophin, increase in response to both acute exercise and training programmes. Elevated serum beta-endorphin concentrations induced by exercise have been linked to several psychological and physiological changes, including mood state changes and exercise-induced euphoria, altered pain perception, menstrual disturbances in female athletes, and the stress responses of numerous hormones (growth hormone, ACTH, prolactin, ...
Naloxone has been reported to have potential benefit in the treatment of stroke. We evaluated the effect of naloxone in a double-blind trial conducted with 15 stroke patients whose deficits ranged from 8 to 60 hours in duration. All but one patient sustained a cerebral infarction. Neurologic function was assessed before and five minutes after each of two injections given to each patient in a double-blind fashion. The injections consisted of naloxone (0.4 mg in 3 patients and 4.0 mg in 12 patients) and saline. Prior to the trial, samples of plasma were obtained for determination of immunoreactive beta-endorphin for each patient. Four patients showed minimal improvement following injection of naloxone, while five patients exhibited a slightly greater improvement following saline injection. There were no significant elevations of plasma beta-endorphin among stroke patients. We conclude that naloxone may not have a significant therapeutic role for stroke in the clinical setting. ...
Baranowska B, Wolińska-Witort E, Martyńska L, Chmielowska M, Mazurczak-Pluta T, Boguradzka A, Baranowska-Bik A. Sibutramine therapy in obese women--effects on plasma neuropeptide Y (NPY), insulin, leptin and beta-endorphin concentrations. Neuro Endocrinol Lett. 2005 Dec; 26(6): 675-679 ...
An 18-20 gauge catheter will be inserted into an arm vein to be used for drawing blood and for administration of either normal saline or naloxone. In a seated position, the patient will breathe quietly through the mouth piece without any resistance. After 5 minutes, 10 ml of venous blood will be removed for measurement of baseline plasma beta-endorphin immunoreactivity. Then, the physician will give the normal saline or naloxone solution intravenously through tubing connected to the catheter. Five minutes after the infusion has been given, the resistance load (obtained at Visit 1) will be added to the inspiratory side of a two-way valve. The patient will be instructed to continue breathing through the resistance for as long as possible. At one minute intervals, the patient will be asked to place a mark on a vertical visual analog scale (VAS) in order to rate separately the intensity and the unpleasantness of dyspnea. When the patient is no longer able to breathe through the resistance system, ...
Endogenous opioid beta-endorphin is released by two different systems - neural network and blood. The first system includes the hypothalamus and the neural network leading to the midbrain and brainstem and this way it can affect the pain sensitivity as well as autonomous functions. There is evidence that the hypothalamus nuclei play a vital role in the mediating effect of acupuncture. Damage in the arcuate nucleus eliminates the analgesic effect of low-frequency but not of high-frequency electro acupuncture. Low-frequency electrical stimulation induced circulatory changes in multiple tissues. These effects are eliminated after hypothalamic damage. Increase in the beta-endorphin levels was observed in the animal brain tissue both after the acupuncture treatment and muscular exercise. Although the details are still unknown, experimental and clinical evidence indicates that acupuncture can also affect the sympathetic nervous system on the hypothalamus-hypophysis level (Figure 2).. The second system ...
Beta-endorphin. Polarised light micrograph of crystals of beta-endorphin, an opioid peptide that relieves pain. Endorphins are a group of peptides (small proteins) that occur in the brain. Beta- endorphin is the most active type. Their effects resemble morphine and other opiate drugs, that is, alteration of the perception of pain. Because they are produced by body cells they were named endorphins (endogenous morphines). Besides the nervous system, they occur at other body sites. Their effects on nerve endings are analgesic (pain killing), while they may also control the bodys response to stress as well as determining mood and pleasure. Magnification: x80 at 6x7cm size. - Stock Image A610/0157
CHECK OUT THIS INTERESTING INFO FROM THE UC RIVERSIDE WEBSITE...WRITTEN BY the AMAZING ATHLETE JOSH EVERETT! WHAT DAY ARE YOU ON??? Detraining Calendar Days 1 - 2 After last day of training Adrenaline and beta-endorphin levels drop. Your mood is affected negatively, but your body stays intact. Aerobic and power capabilities are the same. Days…
Rabbit polyclonal beta Endorphin antibody validated for ICC/IF and tested in Human, Mouse and Rat. Immunogen corresponding to synthetic peptide
Mouse monoclonal beta Endorphin antibody [B 31.15] validated for IHC and tested in Human and Rat. Referenced in 2 publications. Immunogen corresponding to full…
in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1983), 177(2), 259-68. 5 micrograms of human beta-endorphin were labelled with 2 mCi 125I by the chloramine T technique. After two gel filtrations on Sephadex G-15 and on Sephadex G-50 in phosphate buffer with EDTA, Trasylol ... [more ▼]. 5 micrograms of human beta-endorphin were labelled with 2 mCi 125I by the chloramine T technique. After two gel filtrations on Sephadex G-15 and on Sephadex G-50 in phosphate buffer with EDTA, Trasylol and mercapto-ethanol, a pure tracer was obtained with a specific activity about 150 microCi/ug. Kept at + 4 degrees C, the tracer remained utilizable for 30 days without loss of immunoreactivity. The labelling with lactoperoxydase and the use of another gel filtration method (filtration on Aca 202) gave a 125I beta-END tracer with the same immunoreactivity. The binding of this tracer to the antibody of an anti-beta-END antiserum diluted at 1/8000 was 32% with a non specific binding ...
Participants will be breast cancer patients receiving radiation therapy at Massachusetts General Hospital. There will be two groups of patients: those receiving adjuvant radiation therapy alone following surgical tumor resection, and those receiving adjuvant chemotherapy and radiation therapy following surgical tumor resection. Patients receiving any radiation regimen detailed below in section 2b are eligible for the study. In this study the investigators will be drawing blood for beta-endorphin measurement prior to, at various times during, and following patients treatment regimens. In addition, at each blood draw, patients will complete questionnaires that assess fatigue, mood, and pain. These questionnaires have all been validated for use in cancer patients (see Procedures Involving Human Participants section below), and for our study, the investigators have formatted them onto computer tablets for ease of patient completion and data analysis. This study will progress as follows:. Patients: ...
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The nature of the genetic defects which define the obese (ob) and diabetes (db) loci in mice remain unknown, but both produce similar syndromes when maintained in the same strain of mice. There is some evidence suggesting a lesion in the central nervous system (CNS) in db/db mice, while ob/ob mice appear to have a primary lesion outside the CNS. In a search for further evidence of a unique central lesion in db/db mice, we have examined neuropeptide content in selected, microdissected brain areas in both of these mutants and lean controls. In order to rule out possible interactions of the db mutation with the genetic background, diabetes mice of both C57BL/KsJ and C57BL/6J strains were studied. When concentrations of nine neuropeptide immunoreactivities were examined in up to seven microdissected areas of the brain, C57BL/6J ob/ob mice showed only one reproducible alteration, a lower content of beta-endorphin-like immunoreactivity (LI) in the preoptic area at both 3 and 6 weeks of age as
The results showed that (1) in the NRM perfuse liquid, pain stimulation could increase the concentrations of AVP, leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), beta-endorphin (beta-Ep), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), but not change the concentrations of dynorphinA(1-13) (DynA(1-13)), oxytocin, achetylcholine, choline, gamma-aminobutyric acid, glutamate, dopamine, 3,4-dihydroxyphenylacetic acid, homovanilic acid, norepinephrine and epinephrine; (2) in the NRM perfuse liquid, AVP increased the concentrations of L-Ek, M-Ek, beta-Ep, DynA(1-13), 5-HT and 5-HIAA, but did not change the concentrations of oxytocin and the other studied neurotransmitters; (3) AVP antinociception in the NRM was attenuated by cypoheptadine (a 5-HT-receptor antagonist) or naloxone (an opiate receptor antagonist), but was not influenced by the other studied receptor antagonists ...
When you are feeling down with the blues and maybe experiencing symptoms of depression, there may be some causes that are not just due to chemical changes in the brain. In fact, there are many things that have been linked to depression. One substance linked to depression is refined sugars which depletes the levels of beta-endorphins in your system. If you are contemplating eliminating refined sugars, you need to keep your blood sugar levels steady. You can do this quite easily if you eat breakfast every morning and eat regular and timely meals each day. Some things you should eat are whole grains, roots, green vegetables, yellow vegetables. The second thing you can do is to improve your levels of serotonin. You can do this by including protein-rich foods, such as beans, cheese, eggs, and meat (including chicken and fish). A few hours after you eat protein you should eat a complex carbohydrate, such as potatoes, corn, yams, or lima beans. These can be eaten cooked, canned, or raw and will help ...
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects ...
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The variations of plasmatic beta-endorphin and cortisol levels are studied in 3 groups of patients. These subjects are submitted to abdominal surgery following 3 different anaesthetic schemes: neuroleptanalgesia (droperidol and fentanyl), pure analgesia (fentanyl), association halothane - small dose of fentanyl. The study covers the period from premedication through recovery. The results of this work demonstrates that the average level of beta-endorphin in neuroleptanalgesia and pure analgesia series is stable; there is an increase in the halothane series just after the incision until waking up. The average level of cortisol is stable for the 3 series until incision. It is strongly increased in the neuroleptanalgesia series and in the halothane series. This increase is delayed and reduced in the fentanyl series.
Abstract: Neurobiological mechanisms invoking the release of endogenous opioids and depression of stress hormone release are believed to be the basis of acupuncture analgesia. This study compared plasma beta-endorphin and cortisol levels with self assessment scores of intensity of pain, before and after 10 days of electro-acupuncture treatment in patients suffering from chronic pain as a result of osteoarthritis knees. Forty patients of either sex over 40 years with primary osteoarthritis knee were recruited into a single-blinded, sham-controlled study. For electro-acupuncture group the points were selected according to the Traditional Chinese Medicine Meridian Theory. In the sham group needles were inserted at random points away from true acupoints and no current was passed. Both groups were treated for 10 days with one session every day lasting for 20-25min. Pre- and post-treatment Western Ontario and McMaster Universities (WOMAC) index of osteoarthritis knee and Visual Analogue Scale (VAS) ...
Abstract: Neurobiological mechanisms invoking the release of endogenous opioids and depression of stress hormone release are believed to be the basis of acupuncture analgesia. This study compared plasma beta-endorphin and cortisol levels with self assessment scores of intensity of pain, before and after 10 days of electro-acupuncture treatment in patients suffering from chronic pain as a result of osteoarthritis knees. Forty patients of either sex over 40 years with primary osteoarthritis knee were recruited into a single-blinded, sham-controlled study. For electro-acupuncture group the points were selected according to the Traditional Chinese Medicine Meridian Theory. In the sham group needles were inserted at random points away from true acupoints and no current was passed. Both groups were treated for 10 days with one session every day lasting for 20-25min. Pre- and post-treatment Western Ontario and McMaster Universities (WOMAC) index of osteoarthritis knee and Visual Analogue Scale (VAS) ...
Areaumat lavanda stimulates beta endorphin synthesis and inhibits inflammation mediators for a soothing and relaxing effect....Learn more ...
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In the heart of Eagle Ranch Village, Endorphin Eagle Ranch will offer a variety of exercise equipment, workout options and classes to its members. From spin bikes to weightlifting, yoga and Barre classes, the areas only 24-Hour Health Club mixes top-of-the line features with the small-town friendliness that defines Eagle Ranch, and a community that defines Endorphin.. With 5,000 square feet of space, Club members have access to a cardio area that includes stationary bicycles, treadmills, elliptical trainers, circuit training machines and free weights. The separate exercise room, designed for both class use and individual workouts, features a full sound system and 42" monitor. Most cardio equipment includes 15" TV screens.. ...
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if you want to know what structures are available. There once was the thought that an amphipathic helix was required for a particular endorphin to be active, but I havent heard anything about it for years. If you are referring to things like alpha- or beta-endorphin, that has little to do with the structure of the endorphins. These were names given to distinguish the types of endorphins and may reflect nothing more than elution order out of a column or tissue source. Youd probably have to go way back to an old review of the literature to get an explanation of the names, but dont expect there to be much about structure beyond sequence, anyway ...
When you exercise, your body releases chemicals called endorphins. These endorphins interact with the receptors in your brain that reduce your perception of pain. A very large body of scientific evidence shows that people who exercise regularly shows a positive mood and lower rates of depression.There are a number of mechanisms that explain the fact that exercise boost your mood, and one is that of the endorphins. When interacting with the receptors in your brain endorphins trigger a positive feeling in the body, similar to that of morphine.This effect is called runners high, and it is accompanied by a positive approach to the everyday life .Thus, exercise increases your overall health and your sense of well-being, which puts more energy in your step every day.Endorphins act as a sort of analgesics diminishing the perception of pain and as sedatives, producing a feeling of calmness.Regular exercise has multiple positive effects that are been proven to:Reduce stressWard off anxiety and feelings
Another group of non-sex hormones that many people have heard of is the endorphins, which belong to the category of chemicals known as opiates and serve to deaden our pain receptors. Endorphins, which are chemically related to morphine, are produced in response to pain. The natural response to rub an injured area, such as a pinched finger, helps to release endorphins in that area. People who exercise a lot and push their bodies “until it hurts†thereby stimulate the production of endorphins. It is thought that some people who constantly over-exercise and push themselves too much may actually be addicted to their own endorphins which that severe exercise regime releases ...
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Any activity, substance, object, or behavior that has become the major focus of a persons life to the exclusion of other activities, or that has begun to harm the individual or others physically, mentally, or socially is considered an addictive behavior. A person can become addicted, dependent, or compulsively obsessed with anything. Some researchers imply that there are similarities between physical addiction to various chemicals, such as alcohol, and psychological dependence to activities such as sex, work or exercise. It is thought that these behavior activities may produce beta-endorphins in the brain, which makes the person feel "high." Some experts suggest that if a person continues to engage in the activity to achieve this feeling of well-being and euphoria, he may get into an addictive cycle. In so doing, he becomes physically addicted to his own brain chemicals, thus leading to continuation of the behavior even though it may have negative health or social consequences. Most physical ...
My marathon is only three weeks away and right now I need more motivation than ever as I am hitting burnout in training. Luckily, I have reached my taper weeks and race weekend is in sight! The hills of San Francisco are calling my name and I am excited to conquer them. These final weeks I have been looking to different places for motivation. My training buddies have been a huge help along with run club, the Mission Im Possible crew and Hood to Coast teammates. Since I have had to do my last few long runs alone, I have looked to my Endorphin Warrior bracelet for some extra motivation. Endorphin Warrior was kind enough to give all the Nuun Hydration runners a bracelet of their choice. I chose one with the phrase RELENTLESS ...
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The world is moving through challenging times. Sometimes events and circumstances can get heavy. Whilst processing our stuff is positive, wallowing for too long in negativity can be counterproductive. It can create a downward spiral. So how might we keep our heads above water? How might we balance the playing field when were processing density? Well one answer is The Endorphin Effect. Endorphins are chemicals we can produce in our bodies to block negative energy and make us feel positively uplifted and joyful inside. So how do you activate endorphins when needed?...
Street Photography is life; life is Phi. I am an artist with a camera, and I am addicted to the endorphin rush that finding and creating art gives me. We see Phi all around us, we are made of Phi, Phi is the substance of life no matter how it is composed through…
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So my weekends have consisted of studying and food, with a few adventures thrown in. We went to Chicago for a wedding (Congrats Sarah and Rich!) and we also went to a Thousand Foot Krutch concert (awesome, awesome, awesome band!!). Other than that Ive been trying my best to catch up on school and sleep while trying to avoid injuring my foot further. I plan to start swimming tomorrow since I think I have been endorphin deprived for too long. ...
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So there is another way that your body releases endorphins into your bloodstream that I didnt mention... Stress. I didnt mention before because I dont want everyone running around getting stressed to achieve their natural high, that wont work. But it is true, when we are stressed our body naturally excretes endorphins to try and…
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Anyone got some endorphins to spare me?? I mean - really. I literally *just* posted about all things balance last night, right? Well - today, of course, Im now absolutely craving an endorphin rush. I bet you want to know why, right? How could I be craving that when I had such good intentions for…
Endorphins, theres really no better Rx for a mood-boost than that. Well, except for a pretty awesome husband who always seems to know just what will do the trick to snap me out of a funk. Cute story before I dive into the endorphin convo... I had a pretty bad day yesterday, for numerous reasons…
When we learn to use brain in rhythm to alpha, we are slowing our brainwaves down. The benefit of this is that we put ourselves in the ideal brain state for optimal performance and super learning. We become better at analysing complex situations, learning new information, memorising data, and performing elaborate tasks some forms of meditation, relaxation exercises, and activities that enable a sense of calm, also naturally create this alpha state.. According to neuroscientists, the effect of decreasing the brain rhythm from beta to alpha via deep relaxation techniques and the use of binaural beats brain entrainment, changes the levels of certain beneficial brain chemicals.. Studies show that alpha states significantly increase beta-endorphin, norepinephrine and dopamine. These naturally occurring chemicals are linked to feelings of expanded mental clarity and generate an internal environment for new learning and accessing previously learned information. This positive effect lasts for hours and ...
NSP Community Center indoor track, 16 mi 2:15:23, pace 8:28. This felt like marathon pace today. In fact I think maybe its the pace I will shoot for in the marathon next month, around 8:25 to 8:30. No pains except: (1) a muscle pull or something in my back just above the left hip bone, maybe from going 216 laps in the same direction (thats 864 corners); and (2) some stomach upset later (now). I do have problems with stomach upset after hard runs, especially long ones, but usually not if I dont eat within four hours of the run. In this case it was all night; I ran in the morning with only black coffee for breakfast. Maybe its the gels. I dont much like those, but havent found anything I like better. Otherwise I feel great! Those old endorphins. Mostly five and four-breathing until the last mile. Splits: 8:38, 8:22, 8:38, 8:18, 8:39, 8:25, 8:49, 8:20, 8:40, 8:19, 8:39, 8:17, 8:39, 8:15, 8:43, 7:42. Good last mile; it says there was something left in the tank. Water every two miles, gels at ...
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The 90 minute long run. Run 90 minutes at 7:00 - 7:05 pace. If you look above thats faster than the far right number but thats because its where the fitness is. Run the 90 minutes. If it feels easy or when it begins to feel easy increase the pace for the next week. Dont change the 90 minutes. Do this regularly and you will build strength and stamina. Eventually you will get to your 6:45 pace or probably much faster. Your goal should be 5-6 90 minute runs between now and the middle of the track season ...
Bodily train helped personalities sort out their dependancy As within the case of legendary rapper Eminem, who took to sports activities after his keep at a rehab, individuals can tread the trail of sobriety by making train a precedence of their life. At one level of time, Eminem had been hooked on painkillers as he has himself admitted taking 60 capsules a day. In truth, his dependancy was so extreme that in 2005 he was admitted to a hospital, the place docs knowledgeable that he had little probabilities of restoration as all his very important organs have been shutting down. Publish rehab, he discovered it laborious to sleep and consistently required meals to appease the abdomen pains, which invariably led to an elevated weight. It was then that Eminem took to operating. Train offered him the much-needed endorphin rush. "Exercise gave me a natural endorphin high, but it also helped me sleep, so it was perfect. Its easy to understand how people replace addiction with exercise," he mentioned in ...
There is no doubt the highlight surprise trip of the year was Annecy, France. My fault for not doing much research but it was a welcome surprise. Coming directly off the the disaster that was Ironman St George, we rolled into old world beauty. A lake buffeted by the Alps. A quaint French town with outdoor cafes for sunning. I skipped the provided hotel lunch every day and walked into the city square for a fresh sandwich. Once youve experienced on of these you will never eat at Subway again. And then there were the morning runs. I could barely keep up with the boys. My legs were dead. But at the same time I couldnt miss the opportunity to run along the lake and to have the company of the international crew ...
Stiff plastic and a double-injected cuff afford alpine-boot-like downhill performance, but thanks to a walk mode it feels like an alpine-touring boot on the way up. 8.3 lbs; garmontusa.com. Bonus: Further evidence of its split personality: It comes with two interchangeable soles, one a grippier ski-mountaineering sole and one a flatter, traditional alpine sole.. Bummer: All that performance adds up-theyre heavy.. ...
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Shuttle Control is a 16-channel MIDI/CV interface which can recieve USB-MIDI at a number of inputs simultaneously. For instance control signals from a tablet/PC/Mac at the to device socket or USB-MIDI-Keyboard or controllers via the to host
A lélek hormonális tápanyaga, már amennyire képes vagyok ilyet előállítani mások számára is. Hormonal alimento da alma, tanto quanto eu sou capaz de produzir outros, como bem. Hormonal de alimento del alma, por lo que yo soy capaz de producir otros, como el bien. Hormonal nourishment of the soul, as far as I am able to produce such others as well.. ...
A lélek hormonális tápanyaga, már amennyire képes vagyok ilyet előállítani mások számára is. Hormonal alimento da alma, tanto quanto eu sou capaz de produzir outros, como bem. Hormonal de alimento del alma, por lo que yo soy capaz de producir otros, como el bien. Hormonal nourishment of the soul, as far as I am able to produce such others as well.. ...
A KEEPER LIST - 1992 Mountain Cycles San Andreas : 1994 Bontrager Race Lite : 1990 Marin Team Titanium : 1990 Brave Warrior : 1993 Kona Hot : 1994 Merlin Mountain : 1991 Cannonade M700 (Dropped) : 1988 Ritchey Ascent : 1990 Mantis XCR CE : 1990 Yeti Ultimate : 1989? Yeti FRO (Lawill) : 1994 Specialized FSR : 1984 Jack Taylor Super Tourist : 2017 Genesis Vagabond : 2016 Giant Trance SX : 1984 Condor Italia Restomod : 1994 Litespeed Catalyst : 1989 Cinelli SuperCorsa SLX Restomod : 2015 Canyon Ultimate SF : Singular Kite CX : Orange 753 Road(!) : Overburys 650b Project : Holdsworth CafeX Project: 2014 Ritchey Swiss Cross : 2014 Genesis Fugio : Yates Condor Audax 531 : ...
4 HP/TE width, |½ in depth (super slim & therefore shuttle friendly) improved tuners with revolutionary algorithm - especially in low range alternative 440 or 432 Hz root A scale added: selected mode saved on next power up tune your oscillators instantly, just apply the Autopilot in
Im addicted to this building oldish bikes up stuff. The last bike I built up was going to be my last. I have no control over thoughts of builds, thoughts when I see a bargain set of brakes/gears/wheels/tyres et al ...
These are the Rolls Royce of ear buds. Got them for my Jaybird Blue buds X ... what a massive difference. A sound like no other ... this is the best.. ...
2017 Matrixsynth - All posts are presented here for informative, historical and educative purposes as applicable within fair use ...
UV light makes mice churn out a molecule that is a cousin of morphine and heroin, a finding that may explain why some people seek out sunshine.
If you are feeling irritable, angry or sad maybe a shift of positive vibes from flashing a smile is in order. Here are 7 reasons that smiling is beneficial your health and your life.
Has anyone else noticed that some of their best work is in response to someone else trying something similar and missing the mark or abandoning it? No? Probably just me, then. Anyway, someone posted a not quite coherent version of this on Enworld, so I responded with this. So far, Ive enough…
Having fun is something quite crucial. even though everyone has miscellaneous preferences in this topic, we should not forget that it is something everyone enjoys. What is more, it is recommended by miscellaneous professionals, as mostly it is a positive experience that we focus on totally ...
Any number of things contribute to good presentations, not the least of which is their content, but there are other things at play that influence and persuade your audience to either buy in and believe or back away and withdraw their attention. Context matters. Where are you when you begin your story? Where is your […]. ...
At Concertino, I Got to sing a fair bit Played a lot of set (including with some very good opponents) Met some new (to me) people. Cool new people! Got to have good conversation with people (hi, fiddledragon and Kate, among others) I dont usually get to talk to Wrote a new song (see adjacent post)…
As new items come up during the day, add them to the bottom of the list. You will rank them at the end of the day (KEEP ONE LIST. If I write a note on a little slip of paper, I carry it in my hand until I can write it on my list. When I put a note in my pocket, the odds of it ending up on my to-do list decrease exponentially ...
Since January 2017, I felt depressed and stressed. Mainly due to my workmates uncomforting work ethics and my demand on myself to be excellent. I need the money from work so I cant just quit anytime. Couple this with my disinterest in people. I am a yes person so this is definitely alarming. I seem…
Now would be a good time to act, Seven decides. It cues the program, and a small spiderlike drone on the wall leaps silently past Terances head, spraying the two with a mist of fluid, so thin as to be imperceptible. It sinks through the skin and has multiple effects on the victims, the first being an increase in testosterone in males and estrogen in females. Endorphin release is also triggered ...
beta-endorphin. 237-267 met-enkephalin. 237-241 In order to regulate the secretion of ACTH, many substances secreted within ...
"The effect of physical therapy on beta-endorphin levels". Eur. J. Appl. Physiol. 100 (4): 371-82. doi:10.1007/s00421-007-0469-9 ...
Smyth, D.G. (2016) Lipotropin & beta-endorphin: a Perspective. J. Mol Endocrinol.. ... Smyth, D.G., Smith, C.C.F. and Zakarian, S. (1981) Isolation and identification of two new peptides related to β-endorphin. In ... Smyth, D.G., Massey, D.E., Zakarian, S. and Finnie, M.D. (1979) Endorphins are stored in biologically active and inactive forms ... Van Ree, J.M., Smyth, D.G. and Colpaert, F.C. (1979) Dependence creating properties of lipotropin C-Fragment (β-endorphin): ...
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras Endocrinol Metabol (in Portuguese). 52 (4): 589- ... β-endorphin (an endogenous opioid), and phenethylamine (a trace amine and amphetamine analog). A systematic review noted that, ...
Interestingly, some symptoms of OT are related to beta-endorphin (beta-end(1-31)) effects. Some of its effects, such as ... Levels of beta-endorphin in response to exercise and overtraining]". Arq Bras Endocrinol Metabol (in Portuguese). 52 (4): 589- ... β-Endorphin (contracted from "endogenous morphine") is an endogenous opioid neuropeptide that binds to μ-opioid receptors, in ... A review on β-endorphin and exercise noted that an individual's mood improves for the remainder of the day following physical ...
Role of beta-endorphin and cAMP in addiction and mania. Society for Neuroscience Abstracts. 15:149, 1998. Koob G, Kreek MJ ( ...
The release of a POMC product, beta-endorphin is regulated by NPY. Centrally projecting neurons that make somatostatin; the ... Proopiomelanocortin (POMC) is a precursor polypeptide that is cleaved into MSH and β-endorphin and expressed in the arcuate ... β-endorphin, melanocyte-stimulating hormone (MSH), and somatostatin. ...
Keverne, EB; Martensz, ND; Tuite, B (1989). "Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by ... it appears to be relaxing to those who participate due to the release of beta-endorphin. In addition, an increase in maternal ...
Beta-endorphins are found in neurons in the hypothalamus and the pituitary gland. Beta-endorphins are found to be opioid ... Beta- endorphins have been difficult to measure in animal species, differently from oxytocin which can be measured by sampling ... A study in monkeys shows the changes in opiate expression in the body, mirroring changes in beta-endorphin levels, influences ... Grooming stimulates the release of beta-endorphin, which is one physiological reason for why grooming appears to be relaxing. ...
... "increase serum beta-endorphin levels by 44%". Beta-endorphin is associated with feelings of relaxation and euphoria, including ... It triggers the synthesis of vitamin D and endorphins in the skin, but it also causes skin cancer and other damage, including ...
Knepel W, Homolka L, Vlaskovska M, Nutto D. (1984). Stimulation of adrenocorticotropin/beta-endorphin release by synthetic ... and beta-endorphin, and melanocyte-stimulating hormone are released under the influence of hypothalamic corticotropin-releasing ...
Koenig JI, Gudelsky GA, Meltzer HY (1987). "Stimulation of corticosterone and beta-endorphin secretion in the rat by selective ... "Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response". Prog. ... β-Endorphin secretion may contribute to antidepressant, anxiolytic, and analgesic effects. 5-HT1A receptors can be located on ... Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ (1988). "The genomic clone G-21 which resembles a beta- ...
... "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins". Proceedings of the National ... In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments of β-lipotropin. β-Lipotropin is the predominant ... Evidence shows that β-Lipotropin is metabolized into endorphins that can greatly affect mood and behavior and is thus regarded ... beta-Lipotropin at the US National Library of Medicine Medical Subject Headings (MeSH) gamma-Lipotropin at the US National ...
"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin". ... β-endorphin). ACTH stimulates the synthesis of cortisol, glucocorticoids, mineralocorticoids and DHEA. In the short term, CRH ...
Levels of beta-endorphin in response to exercise and overtraining]. Arq Bras Endocrinol Metabol. June 2008, 52 (4): 589-598. ...
... and beta-endorphin". Psychoneuroendocrinology. 20 (5): 499-508. doi:10.1016/0306-4530(94)00077-N. PMID 7675934. Pruessner, JC; ...
... beta-melanocyte stimulating hormone/ beta-endorphin)". Mohamed, F. E. B., Hamza, R. T., Amr, N. H., Youssef, A. M., Kamal, T. M ... β-Endorphin [Met]Enkephalin Although the N-terminal 5 amino acids of β-endorphin are identical to the sequence of [Met] ... β-Endorphin and [Met]enkephalin are endogenous opioid peptides with widespread actions in the brain. The POMC gene is located ... These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin ...
For example, allogrooming has been associated with effects on heart rate, immunity and beta-endorphins; experimental studies ...
In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. ...
... norepinephrine and beta-Endorphin. The adenosine receptor antagonism of caffeine accounts for the first two,[better source ...
"Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception: Possible implications in migraine ...
Other research demonstrated that exercising mice that did not produce beta-endorphin, a mood-elevating hormone, had no change ...
Mizoguchi H, Narita M, Nagase H, Tseng LF (October 2000). "Activation of G-proteins in the mouse pons/medulla by beta-endorphin ... Narita M, Tseng LF (March 1998). "Evidence for the existence of the beta-endorphin-sensitive "epsilon-opioid receptor" in the ... The existence of this receptor was suspected after the endogenous opioid peptide beta-endorphin was shown to produce additional ... a beta (β) subunit, and a gamma (γ) sub-unit. The gamma and beta sub-units are permanently bound together, producing a single G ...
... and mechanical wave activation of the calcium ion channel to beta-endorphin secretion. In practice, acupuncture points are ...
Other names in common use include beta-endorphin acetyltransferase, peptide acetyltransferase, protein N-terminal ... peptide acetyltransferase activity in bovine and rat intermediate pituitaries responsible for the acetylation of beta-endorphin ... O'Donohue TL (1983). "Identification of endorphin acetyltransferase in rat brain and pituitary gland". J. Biol. Chem. 258 (4): ...
They are found within the pre-BötC and act via alpha-1, alpha-2, and beta-noradrenergic mechanisms.NE induces ICAN-dependent ... These include norepinephrine, serotonin, acetylcholine, substance P, ATP, TRH, somatostatin, dopamine, endorphins, and ...
It is one of three endorphins that are produced in humans, the others of which include α-endorphin and γ-endorphin. The amino ... CID 16132316 from PubChem - β-endorphin CID 3081525 from PubChem - β-endorphin (1-9) CID 133304 from PubChem - β-endorphin (2-9 ... Loh HH, Tseng LF, Wei E, Li CH (August 1976). "beta-endorphin is a potent analgesic agent". Proceedings of the National Academy ... Dalayeun JF, Norès JM, Bergal S. "Physiology of beta-endorphins. A close-up view and a review of the literature". Biomedicine ...
Rabbit polyclonal beta Endorphin antibody validated for ICC/IF and tested in Human, Mouse and Rat. Immunogen corresponding to ... Antiserum to beta Endorphin was raised in rabbits by using the N-terminal portion of bovine beta Endorphin conjugated to ... Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous ... ß-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). ß- ...
Role of Beta-Endorphin in Cancer Therapy Fatigue. Official Title Beta-Endorphin as a Mediator of Cancer Therapy-Induced Fatigue ... Role of Beta-Endorphin in Cancer Therapy Fatigue. This study has been terminated. ... In this study the investigators will be drawing blood for beta-endorphin measurement prior to, at various times during, and ... The investigators aim to test whether beta-endorphin, a substance our bodies make in response to painful and stressful stimuli ...
Mouse monoclonal beta Endorphin antibody [B 31.15] validated for IHC and tested in Human and Rat. Referenced in 2 publications ... Anti-beta Endorphin antibody [B 31.15]. See all beta Endorphin primary antibodies. ... Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous ... ab54205, staining beta Endorphin in anterior (upper) and intermediate (lower) lobes of Wistar rat pituitary gland tissue by ...
Endorphins are a group of peptides (small proteins) that occur in the brain. Beta- endorphin is the most active type. Their ... Polarised light micrograph of crystals of beta-endorphin, an opioid peptide that relieves pain. ... Because they are produced by body cells they were named endorphins (endogenous morphines). Besides the nervous system, they ... Beta-endorphin. Polarised light micrograph of crystals of beta-endorphin, an opioid peptide that relieves pain. Endorphins are ...
Novus Biologicals Beta-endorphin Antibody; Alexa Fluor 594; 0.1 mL ... Beta-endorphin Mouse anti-Human, Alexa Fluor 594, Clone: CLIP/1418, ... beta-endorphin, beta-LPH, beta-melanocyte-stimulating hormone, beta-MSH, CLIP, corticotropin-like intermediary peptide, ... Beta-endorphin Monoclonal antibody specifically detects Beta-endorphin in Human samples. It is validated for Flow Cytometry, ...
What is beta-endorphin? Meaning of beta-endorphin as a finance term. What does beta-endorphin mean in finance? ... Definition of beta-endorphin in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Beta-endorphin financial definition of beta-endorphin https://financial-dictionary.thefreedictionary.com/beta-endorphin ... Related to beta-endorphin: dopamine. Beta. The measure of an assets risk in relation to the market (for example, the S&P500) ...
Compare and order beta Endorphin ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. ... Images for product: Endorphin beta (beta-EP) ELISA Kit Diagramm of the ELISA kit to detect Rat beta -EPwith the optical density ... Images for product: Endorphin beta (beta-EP) ELISA Kit Diagramm of the ELISA kit to detect Rat beta -EPwith the optical density ... Images for product: Endorphin beta (beta-EP) ELISA Kit Diagramm of the ELISA kit to detect Rat beta -EPwith the optical density ...
beta-Endorphin (sheep), 27-L-tyrosine-31-L-glutamic acid- , C158H251N39O46S , CID 16132316 - structure, chemical names, ...
Endorphin beta, 50 µl. ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid ... Antiserum to beta Endorphin was raised in rabbits by using the N-terminal portion of bovine beta Endorphin conjugated to ... Product Description for Endorphin beta. Rabbit anti Endorphin beta.. Presentation: Serum. Product is tested for ... beta-Lipotropin 100%Met-enkephalin 0.01%Leu-enkephalin 0.01%beta-Endorphin 0.01%. Species:. Bovine, Chicken, Feline, Human, ...
Beta-endorphin Changes in Serum Leptin and Beta Endorphin Levels with Weight Loss by Electroacupuncture and Diet Restriction ... Substance P and Beta Endorphin Mediate Electroacupuncture Induced Analgesic Activity in Mouse Cancer Pain Model Tagged: *Beta- ... This study aims to investigate the role of changes in leptin and beta endorphin (BE) levels in weight loss following ... Changes in Serum Leptin and Beta Endorphin Levels with Weight Loss by Electroacupuncture and Diet Restriction in Obesity ...
Plasma immunoreactive beta-endorphin levels were markedly decreased in the group treated with anti-h beta-endorphin (P less ... antihuman beta-endorphin (anti-h beta-endorphin), or normal rabbit serum. Three hours later all animals were subjected to a ... beta-endorphin, and corticosterone. Rats treated with anti-h beta-endorphin had a survival rate of 64%, which was significantly ... Effects of immune neutralization of corticotropin-releasing hormone, adrenocorticotropin, and beta-endorphin in the surgically ...
Thus, we assessed (a) the immunocytochemical distribution of beta END and LHRH in the hen ME, (b) the temporal … ... beta END) might have at the median eminence (ME) on luteinizing hormone (LH)-releasing hormone (LHRH) during the ovulatory ... We studied the effect that beta-endorphin (beta END) might have at the median eminence (ME) on luteinizing hormone (LH)- ... Beta-endorphin regulation of LHRH release at the median eminence level: immunocytochemical and physiological evidence in hens ...
Both [beta]-endorphin and morphine, in a dose dependent manner given intraventricularly suppressed the signs of 14 hour acute ... beta]-Endorphin suppression of acute morphine abstinence in morphine dependent monkeys: Effective given intraventricularly but ... On a molar basis, [beta]-endorphin was more active than morphine in suppressing the signs of morphine abstinence. When given ... Citation: Domino, Edward F., Li, Choh Hao (1985/07)."[beta]-Endorphin suppression of acute morphine abstinence in morphine ...
Blutproben zur Bestimmung von ACTH, beta-Endorphin und Cortisol wurden präoperativ sowie am 1., 3. und 7. postoperativen Tag ... Für den perioperativen Verlauf von beta-Endorphin gab es keine signifikanten Unterschiede. Placebo-Patienten hatten eine ... Cortisol und immunreaktiven Beta-Endorphin sowie die postoperative Infektionsrate bei alkoholkranken Patienten ... Plasma immune reactive beta-endorphine levels did not differ between groups. Placebo patients had a significantly increased ...
Differentiation of cells producing poly peptide hormones acth msh lipotropic hormone alpha endorphin beta endorphin growth ... Effects of beta-endorphin fragment 6-31 on morphine- and beta-endorphin-induced growth hormone and prolactin release. European ... Ultrastructural localization of acth beta lipotropin and alpha endorphin and beta endorphin in the porcine anterior pituitary. ... Ultrastructural localization of immuno reactive corticotropin beta lipotropin alpha endorphin and beta endorphin in cells of ...
... beta-endorphin and prolactin in human adolescents of both sexes ... beta-endorphin and prolactin in human adults of both sexes. ... Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin ... Effects of acute alcohol intoxication on pituitary-gonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and ... Effects of acute alcohol intoxication on pituitary-gonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and ...
In both sexes and during both phases of the light cycle rats treated with β-endorphin as infants evidenced a significant ... It was concluded that early exposure to β-endorphin results in permanent changes in behavior perhaps by altering the ... Male and female rat pups were injected with β-endorphin, naloxone or a saline control solution during days 2-7 postnatally. At ... Male and female rat pups were injected with β-endorphin, naloxone or a saline control solution during days 2-7 postnatally. At ...
It is shown that [125I]beta-endorphin is not transported through the BBB, but is rapidly cleaved to free [125I] tyrosine via ... Therefore, chimeric peptide was prepared using [125I] [D-Ala2]beta-endorphin (DABE), owing to the resistance of this analogue ... beta-endorphin, to a transportable peptide vector, e.g. cationized albumin, using disulfide-based coupling reagents such as N- ... beta-endorphin is not transported through the BBB in its unconjugated form, 2) a [125I] DABE-cationized albumin chimeric ...
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During stress, endorphins produce analgesia, which can be blocked by naloxone.3 Endorphins can also induce important ... β-endorphin levels in children with the obesity-hypoventilation or Pick-wickian syndrome and improvement in ventilatory status ... 2 Release of endorphins results in neurotransmitter and neuroendocrine effects in the central nervous system. ... and peripheral vasodilation.4-6 The respiratory effects of endorphins include bradypnea, apnea, and hypoventilation.7, 8We have ...
Plasma beta-endorphin, cortisol and catecholamines were measured before exercise, during maximal exercise, and 10, 20 and 60 ... Plasma beta-endorphin, cortisol and catecholamines were measured before exercise, during maximal exercise, and 10, 20 and 60 ... Plasma beta-endorphin levels increased significantly (P , 0.01) during exercise in symptomatic and asymptomatic patient groups ... The time course of plasma cortisol levels exhibited the same pattern as beta-endorphins with the same significant differences ...
Endorphin, Beta (Rat) _ Antibody for Immunohistochemistry _ 50ul \ H-022-33 for more molecular products just contact us ... WP126: Fatty Acid Beta Oxidation 1. WP1269: Fatty Acid Beta Oxidation. WP1307: Fatty Acid Beta Oxidation. WP1367: TGF-beta ... WP1061: Fatty Acid Beta Oxidation. WP1106: Keap1-Nrf2. WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation. WP113: TGF Beta ... WP1164: TGF Beta Signaling Pathway. WP1177: Fatty Acid Beta Oxidation. WP1207: Fatty Acid Beta Oxidation. WP1224: EBV LMP1 ...
ROLE OF ENDORPHIN TO CONTROL CANCER PAIN IN MAN FOLLOWING PITUITARY ADENOLYSIS.- AN EXPERIMENTAL STUDY OF BETA-ENDORPHIN ... ROLE OF ENDORPHIN TO CONTROL CANCER PAIN IN MAN FOLLOWING PITUITARY ADENOLYSIS.- AN EXPERIMENTAL STUDY OF BETA-ENDORPHIN ... ROLE OF ENDORPHIN TO CONTROL CANCER PAIN IN MAN FOLLOWING PITUITARY ADENOLYSIS.- AN EXPERIMENTAL STUDY OF BETA-ENDORPHIN ... AN EXPERIMENTAL STUDY OF BETA-ENDORPHIN ACTIVITY IN HYPOPHYSECTOMIZED RATS. Anesthesiology 1980;53(3 Suppl):S215. ...
Acute traumatic injury engenders the production of beta-endorphin (BE) and other endogenous opioid ... Pain perception and serum beta-endorphin in trauma patients.: ... Pain perception and serum beta-endorphin in trauma patients.. ... Acute traumatic injury engenders the production of beta-endorphin (BE) and other endogenous opioids. Elevated BE concentration ...
  • Pituitary melanotropes release alpha-melanocyte-stimulating hormone (alpha-MSH) and acetylated beta-endorphin (NAc beta-end) during stress responses. (ru.nl)
  • The premature C2 ovulation occurs 6-7 h after the administration of progesterone (P4) injected 14 h before the spontaneous second (C2) ovulation of a sequence and therefore 7-8 h earlier than expected, (c) the ME in vitro release of beta END in both models, and (d) the effect of beta END and naloxone on in vitro ME-LHRH release in the two models. (nih.gov)
  • During stress, endorphins produce analgesia, which can be blocked by naloxone. (mdedge.com)
  • 4-6 The respiratory effects of endorphins include bradypnea, apnea, and hypoventilation. (mdedge.com)
  • Endorphins released while running could create an euphoric feeling, but the scientific evidence can't support these claims 100% just yet, as the effects of endorphins vary from person to person. (greatist.com)
  • β-Endorphin in global pathways diffuse to different parts of the body through cerebral spinal fluid in the spinal cord, allowing for β-endorphin release to affect the peripheral nervous system. (wikipedia.org)
  • Double immunofluorescence staining of β-endorphin with glial and neuronal cellular biomarkers was also detected in the spinal cord and cultured primary microglia, astrocytes, and neurons. (springer.com)
  • After the conflict, the beta-endorphin deficient mice had higher corticosterone levels but the peak increase in body temperature was not different from that in wild type animals. (elsevier.com)